locus-tag	class	description
C5099_RS00005	COG0716	FMN binding
C5099_RS00010	COG1522	sequence-specific DNA binding
C5099_RS00035	COG1869	D-ribose catabolic process
C5099_RS00040	COG1129	ABC transporter
C5099_RS00045	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5099_RS00050	COG1879	ABC-type sugar transport system periplasmic component
C5099_RS00055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS00060	COG1609	Transcriptional regulator
C5099_RS00065	COG0477	Major facilitator Superfamily
C5099_RS00070	COG2186	Transcriptional regulator
C5099_RS00110	COG3085	chromosome segregation
C5099_RS00115	COG0606	chelatase, subunit chli
C5099_RS00140	COG3978	acetolactate synthase activity
C5099_RS00145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5099_RS00155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5099_RS00160	COG0583	DNA-binding transcription factor activity
C5099_RS00170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5099_RS00175	COG0210	DNA helicase
C5099_RS00195	COG3118	belongs to the thioredoxin family
C5099_RS00205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5099_RS00215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5099_RS00220	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C5099_RS00225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C5099_RS00230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5099_RS00235	COG1088	dTDP-glucose 4,6-dehydratase activity
C5099_RS00240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C5099_RS00245	COG0456	acetyltransferase
C5099_RS00250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5099_RS00255	COG2244	polysaccharide biosynthetic process
C5099_RS00275	COG1113	amino acid transport
C5099_RS00300	COG0641	radical SAM
C5099_RS00305	COG3119	arylsulfatase activity
C5099_RS00310	COG3071	HemY protein
C5099_RS00315	COG2959	enzyme of heme biosynthesis
C5099_RS00320	COG1587	Uroporphyrinogen-III synthase
C5099_RS00335	COG3072	Adenylate cyclase
C5099_RS00355	COG5567	small periplasmic lipoprotein
C5099_RS00365	COG3159	Protein conserved in bacteria
C5099_RS00375	COG1011	Hydrolase
C5099_RS00380	COG0210	DNA helicase
C5099_RS00385	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C5099_RS00390	COG3698	Phosphodiester glycosidase
C5099_RS00395	COG0598	Magnesium transport protein CorA
C5099_RS00400	COG2962	Rard protein
C5099_RS00405	COG2050	protein possibly involved in aromatic compounds catabolism
C5099_RS00410	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C5099_RS00415	COG0514	ATP-dependent DNA helicase (RecQ)
C5099_RS00420	COG1280	lysine exporter protein (LysE YggA)
C5099_RS00425	COG1280	lysine exporter protein (LysE YggA)
C5099_RS00430	COG2267	carboxylic ester hydrolase activity
C5099_RS00435	COG0561	phosphatase activity
C5099_RS00440	COG0697	spore germination
C5099_RS00445	COG0583	DNA-binding transcription factor activity
C5099_RS00465	COG3157	Type VI secretion system effector, Hcp
C5099_RS00470	COG3157	Type VI secretion system effector, Hcp
C5099_RS00480	COG2190	(PTS) system
C5099_RS00480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS00480	COG1263	PTS System
C5099_RS00485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5099_RS00490	COG1737	Transcriptional regulator
C5099_RS00495	COG0583	DNA-binding transcription factor activity
C5099_RS00500	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5099_RS00510	COG0549	Belongs to the carbamate kinase family
C5099_RS00515	COG1304	FMN binding
C5099_RS00520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5099_RS00530	COG1335	isochorismatase
C5099_RS00535	COG0412	Dienelactone hydrolase
C5099_RS00540	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C5099_RS00550	COG1322	Protein conserved in bacteria
C5099_RS00560	COG3165	ubiquinone biosynthetic process from chorismate
C5099_RS00570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5099_RS00580	COG0805	protein transport
C5099_RS00595	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C5099_RS00600	COG0543	2 iron, 2 sulfur cluster binding
C5099_RS00620	COG1739	Uncharacterized protein family UPF0029
C5099_RS00625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5099_RS00630	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C5099_RS00660	COG1763	Mo-molybdopterin cofactor biosynthetic process
C5099_RS00665	COG0746	molybdenum cofactor guanylyltransferase activity
C5099_RS00670	COG3084	Protein conserved in bacteria
C5099_RS00680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5099_RS00685	COG5339	Protein conserved in bacteria
C5099_RS00690	COG0204	Acyl-transferase
C5099_RS00700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5099_RS00700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5099_RS00715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5099_RS00725	COG2204	response regulator
C5099_RS00730	COG3852	Histidine kinase
C5099_RS00735	COG0174	glutamine synthetase
C5099_RS00745	COG1217	gtp-binding protein TYPA
C5099_RS00750	COG2188	Transcriptional regulator
C5099_RS00755	COG1082	Xylose isomerase domain protein TIM barrel
C5099_RS00760	COG2271	Major facilitator Superfamily
C5099_RS00765	COG1349	DNA-binding transcription factor activity
C5099_RS00770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS00775	COG2084	Dehydrogenase
C5099_RS00780	COG3684	Belongs to the aldolase LacD family
C5099_RS00785	COG1063	alcohol dehydrogenase
C5099_RS00795	COG0477	Major facilitator Superfamily
C5099_RS00805	COG1011	Hydrolase
C5099_RS00820	COG0456	acetyltransferase
C5099_RS00825	COG0657	acetylesterase activity
C5099_RS00830	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C5099_RS00865	COG2864	formate dehydrogenase
C5099_RS00870	COG0437	4 iron, 4 sulfur cluster binding
C5099_RS00885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5099_RS00935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5099_RS00950	COG2258	MOSC domain
C5099_RS00955	COG2205	protein histidine kinase activity
C5099_RS00960	COG0745	RESPONSE REGULATOR receiver
C5099_RS00965	COG3678	ATP-independent chaperone mediated protein folding
C5099_RS00970	COG4974	Belongs to the 'phage' integrase family
C5099_RS01030	COG4695	Portal protein
C5099_RS01120	COG5301	cellulose 1,4-beta-cellobiosidase activity
C5099_RS01185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C5099_RS01205	COG3152	Membrane
C5099_RS01210	COG3691	Protein conserved in bacteria
C5099_RS01215	COG0589	response to stress
C5099_RS01225	COG1494	fructose-1,6-bisphosphatase
C5099_RS01235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5099_RS01250	COG1575	Belongs to the MenA family. Type 1 subfamily
C5099_RS01265	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5099_RS01270	COG1609	Transcriptional regulator
C5099_RS01275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5099_RS01285	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C5099_RS01295	COG0626	cystathionine gamma-synthase activity
C5099_RS01300	COG0527	aspartate kinase activity
C5099_RS01300	COG0460	homoserine dehydrogenase
C5099_RS01310	COG0737	Belongs to the 5'-nucleotidase family
C5099_RS01325	COG0737	Belongs to the 5'-nucleotidase family
C5099_RS01330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5099_RS01340	COG0697	spore germination
C5099_RS01345	COG3738	Protein conserved in bacteria
C5099_RS01360	COG0371	Dehydrogenase
C5099_RS01365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5099_RS01370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5099_RS01370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS01370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS01375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS01380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS01385	COG1882	Formate acetyltransferase
C5099_RS01390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5099_RS01395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS01400	COG2207	Transcriptional regulator
C5099_RS01405	COG2194	sulfuric ester hydrolase activity
C5099_RS01420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5099_RS01425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5099_RS01435	COG4948	Mandelate Racemase Muconate Lactonizing
C5099_RS01440	COG2271	Major facilitator Superfamily
C5099_RS01445	COG0583	DNA-binding transcription factor activity
C5099_RS01455	COG1473	amidohydrolase
C5099_RS01460	COG0477	Major facilitator Superfamily
C5099_RS01510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5099_RS01515	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C5099_RS01515	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C5099_RS01560	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5099_RS01565	COG0250	Participates in transcription elongation, termination and antitermination
C5099_RS01605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5099_RS01615	COG2104	thiamine diphosphate biosynthetic process
C5099_RS01620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5099_RS01630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5099_RS01655	COG3068	Protein conserved in bacteria
C5099_RS01670	COG3678	ATP-independent chaperone mediated protein folding
C5099_RS01680	COG4191	Histidine kinase
C5099_RS01685	COG2204	response regulator
C5099_RS01690	COG0151	Belongs to the GarS family
C5099_RS01695	COG0138	bifunctional purine biosynthesis protein purh
C5099_RS01735	COG0456	acetyltransferase
C5099_RS01745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5099_RS01750	COG2224	Isocitrate lyase
C5099_RS01760	COG1414	Transcriptional regulator
C5099_RS01765	COG0646	methionine synthase
C5099_RS01765	COG1410	methionine synthase
C5099_RS01780	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5099_RS01835	COG0527	aspartate kinase activity
C5099_RS01870	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5099_RS01885	COG3833	ABC-type maltose transport systems, permease component
C5099_RS01890	COG1175	transmembrane transport
C5099_RS01895	COG2182	Extracellular solute-binding protein
C5099_RS01940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C5099_RS01950	COG0534	Mate efflux family protein
C5099_RS01955	COG3237	CsbD-like
C5099_RS01960	COG0735	belongs to the Fur family
C5099_RS01965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5099_RS01975	COG0604	alcohol dehydrogenase
C5099_RS01980	COG0305	Participates in initiation and elongation during chromosome replication
C5099_RS01985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5099_RS01990	COG1448	Aminotransferase
C5099_RS01995	COG0567	Dehydrogenase, E1 component
C5099_RS02010	COG0045	succinate-CoA ligase (ADP-forming) activity
C5099_RS02015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5099_RS02025	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C5099_RS02030	COG2204	response regulator
C5099_RS02040	COG3700	Belongs to the class B bacterial acid phosphatase family
C5099_RS02045	COG0432	Pfam Uncharacterised protein family UPF0047
C5099_RS02050	COG2315	Protein conserved in bacteria
C5099_RS02055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5099_RS02065	COG0629	single-stranded DNA binding
C5099_RS02080	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C5099_RS02085	COG2207	Transcriptional regulator
C5099_RS02090	COG0789	Transcriptional regulator
C5099_RS02110	COG2252	PERMEase
C5099_RS02115	COG0025	NhaP-type Na H and K H
C5099_RS02120	COG0583	DNA-binding transcription factor activity
C5099_RS02125	COG1380	Effector of murein hydrolase LrgA
C5099_RS02130	COG1346	cytolysis
C5099_RS02140	COG3162	membrane
C5099_RS02145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5099_RS02165	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C5099_RS02170	COG0437	4 iron, 4 sulfur cluster binding
C5099_RS02175	COG3301	Polysulphide reductase, NrfD
C5099_RS02180	COG1138	Cytochrome C-type biogenesis protein
C5099_RS02185	COG3088	subunit of a heme lyase
C5099_RS02190	COG4235	cytochrome complex assembly
C5099_RS02200	COG1301	dicarboxylic acid transport
C5099_RS02205	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C5099_RS02210	COG4608	Belongs to the ABC transporter superfamily
C5099_RS02215	COG0444	Belongs to the ABC transporter superfamily
C5099_RS02220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5099_RS02225	COG0601	transmembrane transport
C5099_RS02240	COG1538	Outer membrane efflux protein
C5099_RS02245	COG1289	transmembrane transporter activity
C5099_RS02250	COG1566	PFAM secretion protein HlyD family protein
C5099_RS02260	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C5099_RS02270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5099_RS02275	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5099_RS02280	COG1129	ABC transporter
C5099_RS02285	COG1879	ABC-type sugar transport system periplasmic component
C5099_RS02290	COG1737	Transcriptional regulator
C5099_RS02300	COG0698	ribose 5-phosphate isomerase
C5099_RS02310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5099_RS02315	COG0456	acetyltransferase
C5099_RS02320	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C5099_RS02325	COG3454	Phosphonate metabolism
C5099_RS02330	COG4778	phosphonate C-P lyase system protein PhnL
C5099_RS02335	COG4107	phosphonate C-P lyase system protein PhnK
C5099_RS02340	COG3627	carbon phosphorus lyase activity
C5099_RS02345	COG3626	phosphonate metabolism
C5099_RS02350	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C5099_RS02355	COG3624	Phosphonate C-P lyase system protein PhnG
C5099_RS02360	COG2188	Transcriptional regulator
C5099_RS02365	COG3639	organic phosphonate transmembrane transporter activity
C5099_RS02370	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C5099_RS02380	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C5099_RS02390	COG2824	Alkylphosphonate utilization operon protein PhnA
C5099_RS02410	COG0477	Major facilitator Superfamily
C5099_RS02420	COG0642	Histidine kinase
C5099_RS02425	COG0745	RESPONSE REGULATOR receiver
C5099_RS02430	COG2194	sulfuric ester hydrolase activity
C5099_RS02435	COG0531	amino acid
C5099_RS02440	COG2207	Transcriptional regulator
C5099_RS02445	COG1982	Orn Lys Arg decarboxylase major
C5099_RS02450	COG2169	Transcriptional regulator
C5099_RS02460	COG1486	melibiose metabolic process
C5099_RS02465	COG3647	Membrane
C5099_RS02470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5099_RS02470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5099_RS02475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C5099_RS02485	COG4565	transcriptional regulatory protein
C5099_RS02490	COG3290	protein histidine kinase activity
C5099_RS02495	COG3592	Divergent 4Fe-4S mono-cluster
C5099_RS02500	COG2388	GCN5-related N-acetyl-transferase
C5099_RS02515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5099_RS02520	COG3104	oligopeptide transport
C5099_RS02525	COG1982	Orn Lys Arg decarboxylase major
C5099_RS02530	COG0531	amino acid
C5099_RS02555	COG1309	transcriptional regulator
C5099_RS02560	COG4232	protein-disulfide reductase activity
C5099_RS02570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C5099_RS02575	COG1027	Aspartate ammonia-lyase
C5099_RS02580	COG3030	protein affecting phage T7 exclusion by the F plasmid
C5099_RS02585	COG0531	amino acid
C5099_RS02610	COG1509	lysine 2,3-aminomutase activity
C5099_RS02620	COG5510	response to toxic substance
C5099_RS02625	COG5510	response to toxic substance
C5099_RS02630	COG2076	Multidrug Resistance protein
C5099_RS02635	COG3040	lipid binding
C5099_RS02640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5099_RS02655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5099_RS02670	COG0531	amino acid
C5099_RS02685	COG3264	Mechanosensitive ion channel
C5099_RS02685	COG1511	domain protein
C5099_RS02725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5099_RS02730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5099_RS02730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5099_RS02735	COG0802	atpase or kinase
C5099_RS02740	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5099_RS02760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5099_RS02765	COG0330	HflC and HflK could
C5099_RS02770	COG0330	HflC and HflK could
C5099_RS02775	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C5099_RS02790	COG0557	exoribonuclease II activity
C5099_RS02795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5099_RS02805	COG3789	protein conserved in bacteria
C5099_RS02810	COG1842	Phage shock protein A
C5099_RS02825	COG5463	Belongs to the UPF0441 family
C5099_RS02830	COG0754	glutathionylspermidine amidase activity
C5099_RS02835	COG1960	acyl-CoA dehydrogenase activity
C5099_RS02850	COG3650	response to hydrogen peroxide
C5099_RS02855	COG1073	alpha beta
C5099_RS02870	COG3037	sugar-specific permease SgaT UlaA
C5099_RS02875	COG3414	Phosphotransferase system galactitol-specific IIB component
C5099_RS02915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5099_RS02940	COG2271	Major facilitator Superfamily
C5099_RS02945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5099_RS02950	COG4670	ketone body catabolic process
C5099_RS02955	COG1024	Enoyl-CoA hydratase
C5099_RS02970	COG1309	transcriptional regulator
C5099_RS02975	COG3061	Opacity-associated protein A
C5099_RS02980	COG0545	Peptidyl-prolyl cis-trans isomerase
C5099_RS02985	COG1113	amino acid transport
C5099_RS02995	COG0697	spore germination
C5099_RS03000	COG0702	epimerase
C5099_RS03005	COG1733	regulation of RNA biosynthetic process
C5099_RS03010	COG0737	Belongs to the 5'-nucleotidase family
C5099_RS03015	COG1218	3'(2'),5'-bisphosphate nucleotidase
C5099_RS03020	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C5099_RS03030	COG1253	flavin adenine dinucleotide binding
C5099_RS03045	COG0729	surface antigen
C5099_RS03050	COG2911	Protein conserved in bacteria
C5099_RS03055	COG2105	PFAM AIG2 family protein
C5099_RS03060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5099_RS03065	COG1879	ABC-type sugar transport system periplasmic component
C5099_RS03070	COG1129	ABC transporter
C5099_RS03075	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5099_RS03080	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5099_RS03090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5099_RS03100	COG0312	modulator of DNA gyrase
C5099_RS03105	COG3783	Cytochrome b(562)
C5099_RS03110	COG0602	queuosine metabolic process
C5099_RS03115	COG1328	CTP reductase activity
C5099_RS03120	COG0366	Alpha amylase catalytic
C5099_RS03125	COG1263	PTS System
C5099_RS03125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS03130	COG1609	Transcriptional regulator
C5099_RS03140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5099_RS03145	COG0251	oxidation-reduction process
C5099_RS03165	COG1438	arginine binding
C5099_RS03170	COG1288	antiporter activity
C5099_RS03175	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5099_RS03180	COG0549	Belongs to the carbamate kinase family
C5099_RS03190	COG2731	YhcH YjgK YiaL family protein
C5099_RS03195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5099_RS03200	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C5099_RS03205	COG0456	acetyltransferase
C5099_RS03215	COG0525	valine-tRNA ligase activity
C5099_RS03220	COG2927	DNA polymerase III (CHI subunit)
C5099_RS03235	COG0795	lipopolysaccharide-transporting ATPase activity
C5099_RS03240	COG0433	COG0433 Predicted ATPase
C5099_RS03245	COG1064	alcohol dehydrogenase
C5099_RS03255	COG0582	viral genome integration into host DNA
C5099_RS03335	COG0582	viral genome integration into host DNA
C5099_RS03360	COG2963	transposase activity
C5099_RS03395	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C5099_RS03410	COG0582	viral genome integration into host DNA
C5099_RS03415	COG4974	Belongs to the 'phage' integrase family
C5099_RS03425	COG3539	Fimbrial protein
C5099_RS03430	COG3539	Fimbrial protein
C5099_RS03435	COG3121	Chaperone
C5099_RS03440	COG3188	usher protein
C5099_RS03445	COG3539	Fimbrial protein
C5099_RS03450	COG3539	Fimbrial protein
C5099_RS03470	COG0246	Mannitol dehydrogenase
C5099_RS03475	COG2186	Transcriptional regulator
C5099_RS03480	COG3518	anti-sigma factor antagonist activity
C5099_RS03485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5099_RS03485	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS03490	COG1461	Dihydroxyacetone kinase
C5099_RS03495	COG2376	Dihydroxyacetone kinase
C5099_RS03510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5099_RS03525	COG1929	Belongs to the glycerate kinase type-1 family
C5099_RS03530	COG2084	Dehydrogenase
C5099_RS03535	COG3622	Belongs to the hyi family
C5099_RS03540	COG3960	tartronate-semialdehyde synthase activity
C5099_RS03545	COG3284	Transcriptional regulator
C5099_RS03560	COG1757	Na H antiporter
C5099_RS03565	COG0583	DNA-binding transcription factor activity
C5099_RS03570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5099_RS03575	COG0700	Nucleoside recognition
C5099_RS03580	COG3366	ferrous iron transmembrane transporter activity
C5099_RS03595	COG0477	Major facilitator Superfamily
C5099_RS03610	COG1924	4 iron, 4 sulfur cluster binding
C5099_RS03615	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C5099_RS03630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5099_RS03635	COG5457	Domain of unknown function (DUF1127)
C5099_RS03655	COG1715	Restriction endonuclease
C5099_RS03670	COG0523	cobalamin synthesis protein
C5099_RS03675	COG2879	small protein
C5099_RS03690	COG0840	transmembrane signaling receptor activity
C5099_RS03705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5099_RS03710	COG0025	NhaP-type Na H and K H
C5099_RS03715	COG1802	Transcriptional regulator
C5099_RS03720	COG1063	alcohol dehydrogenase
C5099_RS03725	COG1368	sulfuric ester hydrolase activity
C5099_RS03735	COG1484	DNA-dependent DNA replication
C5099_RS03750	COG2966	Psort location CytoplasmicMembrane, score
C5099_RS03755	COG2197	response regulator
C5099_RS03760	COG2197	response regulator
C5099_RS03765	COG4114	ferric iron reductase
C5099_RS03790	COG2813	Specifically methylates the guanine in position
C5099_RS03795	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C5099_RS03800	COG0456	acetyltransferase
C5099_RS03805	COG1011	Hydrolase
C5099_RS03815	COG2823	Periplasmic or secreted lipoprotein
C5099_RS03825	COG4667	esterase of the alpha-beta hydrolase superfamily
C5099_RS03830	COG0084	hydrolase, TatD family'
C5099_RS03835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5099_RS03840	COG1328	CTP reductase activity
C5099_RS03875	COG3726	membrane protein affecting hemolysin expression
C5099_RS03880	COG0560	Phosphoserine phosphatase
C5099_RS03885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5099_RS03900	COG0488	(ABC) transporter
C5099_RS03905	COG0741	lytic transglycosylase activity
C5099_RS03925	COG3708	Transcriptional regulator
C5099_RS03925	COG2207	Transcriptional regulator
C5099_RS03930	COG3045	CreA protein
C5099_RS03935	COG0745	RESPONSE REGULATOR receiver
C5099_RS03940	COG2205	protein histidine kinase activity
C5099_RS03945	COG4452	Inner membrane protein CreD
C5099_RS03950	COG0745	RESPONSE REGULATOR receiver
C5099_RS03960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C5099_RS03970	COG0527	aspartate kinase activity
C5099_RS03970	COG0460	homoserine dehydrogenase
C5099_RS03975	COG0083	homoserine kinase activity
C5099_RS03980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5099_RS03995	COG1115	amino acid carrier protein
C5099_RS04005	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5099_RS04010	COG1584	GPR1 FUN34 yaaH family protein
C5099_RS04015	COG4735	regulation of single-species biofilm formation
C5099_RS04050	COG3119	arylsulfatase activity
C5099_RS04065	COG0583	DNA-binding transcription factor activity
C5099_RS04080	COG0196	riboflavin kinase activity
C5099_RS04095	COG1047	Peptidyl-prolyl cis-trans
C5099_RS04125	COG0505	Belongs to the CarA family
C5099_RS04185	COG0644	oxidoreductase
C5099_RS04190	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C5099_RS04195	COG2271	Major facilitator Superfamily
C5099_RS04210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5099_RS04240	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C5099_RS04245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5099_RS04255	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C5099_RS04260	COG0564	pseudouridine synthase activity
C5099_RS04270	COG0417	DNA replication proofreading
C5099_RS04275	COG0235	Class ii aldolase
C5099_RS04295	COG4977	sequence-specific DNA binding
C5099_RS04300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS04305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5099_RS04310	COG3181	Tripartite tricarboxylate transporter family receptor
C5099_RS04325	COG0586	Pfam SNARE associated Golgi protein
C5099_RS04335	COG1178	ABC-type Fe3 transport system permease component
C5099_RS04340	COG4143	(ABC) transporter
C5099_RS04365	COG0473	3-isopropylmalate dehydrogenase activity
C5099_RS04380	COG0583	DNA-binding transcription factor activity
C5099_RS04385	COG0028	Belongs to the TPP enzyme family
C5099_RS04390	COG0440	acetolactate synthase activity
C5099_RS04400	COG1609	Transcriptional regulator
C5099_RS04420	COG3116	cell division
C5099_RS04425	COG0768	penicillin binding
C5099_RS04430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5099_RS04435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5099_RS04445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5099_RS04450	COG0772	Belongs to the SEDS family
C5099_RS04465	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5099_RS04470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5099_RS04475	COG0849	cell division
C5099_RS04480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5099_RS04500	COG0494	nUDIX hydrolase
C5099_RS04510	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C5099_RS04520	COG0237	dephospho-CoA kinase activity
C5099_RS04530	COG1459	type II secretion system
C5099_RS04535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5099_RS04540	COG4969	Belongs to the N-Me-Phe pilin family
C5099_RS04550	COG0157	Belongs to the NadC ModD family
C5099_RS04555	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5099_RS04560	COG3725	Membrane protein required for beta-lactamase induction
C5099_RS04570	COG2186	Transcriptional regulator
C5099_RS04580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5099_RS04585	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5099_RS04590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5099_RS04595	COG3064	Membrane
C5099_RS04610	COG1049	propionate catabolic process, 2-methylcitrate cycle
C5099_RS04635	COG2132	Multicopper oxidase
C5099_RS04640	COG4993	Dehydrogenase
C5099_RS04645	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C5099_RS04650	COG0288	reversible hydration of carbon dioxide
C5099_RS04655	COG1131	(ABC) transporter
C5099_RS04660	COG0842	Transport permease protein
C5099_RS04665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS04670	COG0726	polysaccharide deacetylase
C5099_RS04685	COG5464	transposase or invertase
C5099_RS04690	COG5464	transposase or invertase
C5099_RS04705	COG3539	Fimbrial protein
C5099_RS04710	COG3539	Fimbrial protein
C5099_RS04715	COG3539	Fimbrial protein
C5099_RS04720	COG3539	Fimbrial protein
C5099_RS04725	COG3188	usher protein
C5099_RS04730	COG3121	Chaperone
C5099_RS04735	COG3539	Fimbrial protein
C5099_RS04740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5099_RS04745	COG0617	tRNA 3'-terminal CCA addition
C5099_RS04750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5099_RS04755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5099_RS04765	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C5099_RS04770	COG1643	Atp-dependent helicase
C5099_RS04775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5099_RS04780	COG4774	siderophore transport
C5099_RS04785	COG1120	ATPase activity
C5099_RS04790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5099_RS04795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5099_RS04815	COG2860	membrane
C5099_RS04820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5099_RS04840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5099_RS04845	COG3835	regulator
C5099_RS04865	COG0024	Methionine aminopeptidase
C5099_RS04895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5099_RS04900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5099_RS04905	COG0575	Belongs to the CDS family
C5099_RS04920	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C5099_RS04925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5099_RS04950	COG0587	DNA-directed DNA polymerase activity
C5099_RS04960	COG1982	Orn Lys Arg decarboxylase major
C5099_RS04965	COG0346	lactoylglutathione lyase activity
C5099_RS04975	COG4568	rho-dependent transcription termination
C5099_RS04985	COG4681	YaeQ
C5099_RS04990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5099_RS04995	COG3015	lipoprotein NlpE involved in copper resistance
C5099_RS05000	COG0791	NLP P60 protein
C5099_RS05010	COG1720	tRNA m6t6A37 methyltransferase activity
C5099_RS05020	COG1464	Belongs to the NlpA lipoprotein family
C5099_RS05025	COG2011	ABC-type metal ion transport system permease component
C5099_RS05030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5099_RS05035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5099_RS05070	COG0656	L-ascorbic acid biosynthetic process
C5099_RS05075	COG0583	DNA-binding transcription factor activity
C5099_RS05090	COG1388	LysM domain
C5099_RS05090	COG0741	lytic transglycosylase activity
C5099_RS05100	COG2226	methyltransferase
C5099_RS05110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5099_RS05125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5099_RS05135	COG1960	acyl-CoA dehydrogenase activity
C5099_RS05145	COG0121	glutamine amidotransferase
C5099_RS05150	COG3034	peptidoglycan biosynthetic process
C5099_RS05155	COG0791	NLP P60 protein
C5099_RS05185	COG0454	-acetyltransferase
C5099_RS05190	COG1690	Belongs to the RtcB family
C5099_RS05195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5099_RS05200	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5099_RS05220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C5099_RS05240	COG0582	viral genome integration into host DNA
C5099_RS05245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5099_RS05250	COG0210	DNA helicase
C5099_RS05320	COG3477	response to acidic pH
C5099_RS05330	COG0727	PFAM Uncharacterised protein family (UPF0153)
C5099_RS05400	COG1902	pentaerythritol trinitrate reductase activity
C5099_RS05405	COG1073	alpha beta
C5099_RS05420	COG0667	Aldo Keto reductase
C5099_RS05425	COG0656	L-ascorbic acid biosynthetic process
C5099_RS05430	COG1388	LysM domain
C5099_RS05440	COG2207	Transcriptional regulator
C5099_RS05440	COG3708	Transcriptional regulator
C5099_RS05445	COG0656	L-ascorbic acid biosynthetic process
C5099_RS05450	COG3059	membrane
C5099_RS05460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5099_RS05465	COG2207	Transcriptional regulator
C5099_RS05470	COG0247	lactate metabolic process
C5099_RS05475	COG1139	Iron-sulfur cluster binding protein
C5099_RS05480	COG1556	Lactate utilization protein
C5099_RS05520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5099_RS05530	COG2200	EAL domain
C5099_RS05530	COG2771	luxR family
C5099_RS05535	COG0583	DNA-binding transcription factor activity
C5099_RS05550	COG0666	response to abiotic stimulus
C5099_RS05560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5099_RS05565	COG1304	FMN binding
C5099_RS05570	COG0549	Belongs to the carbamate kinase family
C5099_RS05575	COG0402	S-adenosylhomocysteine deaminase activity
C5099_RS05580	COG1064	alcohol dehydrogenase
C5099_RS05590	COG1280	lysine exporter protein (LysE YggA)
C5099_RS05600	COG3829	transcription factor binding
C5099_RS05605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C5099_RS05610	COG0372	Belongs to the citrate synthase family
C5099_RS05615	COG2079	MmgE PrpD family protein
C5099_RS05620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5099_RS05625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5099_RS05630	COG0402	S-adenosylhomocysteine deaminase activity
C5099_RS05635	COG0110	maltose O-acetyltransferase activity
C5099_RS05640	COG2223	nitrite transmembrane transporter activity
C5099_RS05655	COG1609	Transcriptional regulator
C5099_RS05665	COG3122	Protein conserved in bacteria
C5099_RS05685	COG4521	taurine ABC transporter
C5099_RS05690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5099_RS05695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5099_RS05710	COG0113	porphobilinogen synthase activity
C5099_RS05715	COG3468	outer membrane autotransporter barrel domain protein
C5099_RS05720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5099_RS05725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5099_RS05735	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C5099_RS05760	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5099_RS05775	COG1785	Belongs to the alkaline phosphatase family
C5099_RS05785	COG3706	GGDEF domain
C5099_RS05790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5099_RS05815	COG4126	flavin adenine dinucleotide binding
C5099_RS05840	COG1940	carbohydrate kinase activity
C5099_RS05845	COG2814	Major facilitator Superfamily
C5099_RS05850	COG0419	ATPase involved in DNA repair
C5099_RS05855	COG0420	3'-5' exonuclease activity
C5099_RS05860	COG0745	RESPONSE REGULATOR receiver
C5099_RS05865	COG5002	protein histidine kinase activity
C5099_RS05870	COG1114	Component of the transport system for branched-chain amino acids
C5099_RS05875	COG1113	amino acid transport
C5099_RS05900	COG1862	Preprotein translocase
C5099_RS05905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5099_RS05910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5099_RS05915	COG3609	addiction module antidote protein, CC2985 family
C5099_RS05925	COG1403	HNH endonuclease
C5099_RS05930	COG3248	Nucleoside-binding outer membrane protein
C5099_RS05935	COG4238	major outer membrane lipoprotein
C5099_RS05945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5099_RS05945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5099_RS05960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5099_RS05965	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C5099_RS05970	COG0667	Aldo Keto reductase
C5099_RS05980	COG0142	geranyltranstransferase activity
C5099_RS05995	COG0693	protein deglycase activity
C5099_RS06000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5099_RS06010	COG2814	Major facilitator Superfamily
C5099_RS06020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C5099_RS06025	COG1845	cytochrome c oxidase, subunit III
C5099_RS06030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5099_RS06035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5099_RS06040	COG2223	nitrite transmembrane transporter activity
C5099_RS06045	COG3056	Lipoprotein
C5099_RS06055	COG0271	Belongs to the BolA IbaG family
C5099_RS06080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5099_RS06085	COG0776	regulation of translation
C5099_RS06090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5099_RS06095	COG1555	photosystem II stabilization
C5099_RS06100	COG0824	Thioesterase
C5099_RS06110	COG4533	DNA binding
C5099_RS06115	COG0561	phosphatase activity
C5099_RS06120	COG1522	sequence-specific DNA binding
C5099_RS06125	COG1132	(ABC) transporter
C5099_RS06130	COG1132	(ABC) transporter
C5099_RS06135	COG0347	Belongs to the P(II) protein family
C5099_RS06140	COG0004	ammonium transporteR
C5099_RS06145	COG1946	Acyl-CoA thioesterase
C5099_RS06150	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C5099_RS06160	COG3695	enzyme binding
C5099_RS06170	COG5507	3-demethylubiquinone-9 3-methyltransferase
C5099_RS06175	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C5099_RS06185	COG0110	maltose O-acetyltransferase activity
C5099_RS06200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5099_RS06205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5099_RS06210	COG1309	transcriptional regulator
C5099_RS06215	COG3264	Mechanosensitive ion channel
C5099_RS06215	COG1196	nuclear chromosome segregation
C5099_RS06225	COG3923	Primosomal replication protein n
C5099_RS06230	COG2832	Protein of unknown function (DUF454)
C5099_RS06245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5099_RS06285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS06290	COG4651	solute:proton antiporter activity
C5099_RS06290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5099_RS06295	COG2223	nitrite transmembrane transporter activity
C5099_RS06305	COG0737	Belongs to the 5'-nucleotidase family
C5099_RS06310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5099_RS06320	COG3735	TraB family
C5099_RS06325	COG3549	Plasmid maintenance system killer
C5099_RS06330	COG3093	addiction module antidote protein HigA
C5099_RS06335	COG2217	Heavy metal translocating P-type atpase
C5099_RS06345	COG0531	amino acid
C5099_RS06350	COG0789	Transcriptional regulator
C5099_RS06360	COG1585	Membrane protein implicated in regulation of membrane protease activity
C5099_RS06365	COG0330	HflC and HflK could
C5099_RS06370	COG4619	ABC transporter
C5099_RS06375	COG0390	transport system, permease component
C5099_RS06380	COG3118	belongs to the thioredoxin family
C5099_RS06385	COG0300	oxidoreductase activity
C5099_RS06390	COG2755	lipolytic protein G-D-S-L family
C5099_RS06395	COG4181	ATPase activity
C5099_RS06400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C5099_RS06420	COG1414	Transcriptional regulator
C5099_RS06425	COG3960	tartronate-semialdehyde synthase activity
C5099_RS06430	COG3622	Belongs to the hyi family
C5099_RS06435	COG2084	Dehydrogenase
C5099_RS06440	COG1953	Uracil, thiamine, allantoin
C5099_RS06450	COG2233	PERMEase
C5099_RS06455	COG1929	Belongs to the glycerate kinase type-1 family
C5099_RS06460	COG3257	ureidoglycine aminohydrolase activity
C5099_RS06465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5099_RS06470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C5099_RS06475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5099_RS06480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5099_RS06490	COG0549	Belongs to the carbamate kinase family
C5099_RS06500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C5099_RS06505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5099_RS06520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5099_RS06530	COG1988	membrane-bound metal-dependent
C5099_RS06535	COG2501	S4 domain
C5099_RS06555	COG0582	viral genome integration into host DNA
C5099_RS06645	COG2076	Multidrug Resistance protein
C5099_RS06650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5099_RS06655	COG1881	PFAM PEBP family protein
C5099_RS06660	COG2207	Transcriptional regulator
C5099_RS06710	COG3772	lysozyme
C5099_RS06735	COG4220	transposase activity
C5099_RS06755	COG1030	water channel activity
C5099_RS06805	COG1196	nuclear chromosome segregation
C5099_RS06840	COG5301	cellulose 1,4-beta-cellobiosidase activity
C5099_RS06845	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C5099_RS06850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5099_RS06860	COG0500	methyltransferase
C5099_RS06870	COG2207	Transcriptional regulator
C5099_RS06875	COG4571	Outer membrane protease
C5099_RS06900	COG0500	methyltransferase
C5099_RS06905	COG4571	Outer membrane protease
C5099_RS06915	COG4783	chaperone-mediated protein folding
C5099_RS06920	COG1215	transferase activity, transferring glycosyl groups
C5099_RS06925	COG5002	protein histidine kinase activity
C5099_RS06930	COG0745	RESPONSE REGULATOR receiver
C5099_RS06940	COG1538	Outer membrane efflux protein
C5099_RS06945	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5099_RS06950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5099_RS06955	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5099_RS06960	COG1113	amino acid transport
C5099_RS06965	COG0668	transmembrane transport
C5099_RS06970	COG0778	Nitroreductase
C5099_RS06975	COG2315	Protein conserved in bacteria
C5099_RS07005	COG2977	Belongs to the P-Pant transferase superfamily
C5099_RS07010	COG4771	TonB-dependent receptor
C5099_RS07015	COG2382	esterase
C5099_RS07020	COG3251	PFAM MbtH domain protein
C5099_RS07025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5099_RS07025	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C5099_RS07040	COG1120	ATPase activity
C5099_RS07050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5099_RS07060	COG4592	Periplasmic binding protein
C5099_RS07065	COG1169	isochorismate synthase
C5099_RS07070	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5099_RS07075	COG3433	isochorismatase activity
C5099_RS07075	COG1535	isochorismatase
C5099_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS07085	COG2050	protein possibly involved in aromatic compounds catabolism
C5099_RS07090	COG1966	Carbon starvation protein
C5099_RS07095	COG2879	small protein
C5099_RS07100	COG0371	Dehydrogenase
C5099_RS07105	COG0436	Aminotransferase
C5099_RS07110	COG1475	DNA binding
C5099_RS07115	COG3969	phosphoadenosine phosphosulfate
C5099_RS07120	COG0583	DNA-binding transcription factor activity
C5099_RS07125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5099_RS07130	COG0450	alkyl hydroperoxide reductase
C5099_RS07135	COG3634	alkyl hydroperoxide reductase activity
C5099_RS07140	COG0589	response to stress
C5099_RS07145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5099_RS07155	COG3719	Belongs to the RNase T2 family
C5099_RS07160	COG0471	metal ion transport
C5099_RS07175	COG3051	citrate lyase alpha subunit
C5099_RS07180	COG2301	Belongs to the HpcH HpaI aldolase family
C5099_RS07190	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C5099_RS07195	COG3290	protein histidine kinase activity
C5099_RS07200	COG4565	transcriptional regulatory protein
C5099_RS07205	COG3069	C4-dicarboxylate transmembrane transporter activity
C5099_RS07230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5099_RS07235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5099_RS07270	COG1686	Belongs to the peptidase S11 family
C5099_RS07275	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5099_RS07280	COG0772	Belongs to the SEDS family
C5099_RS07285	COG0768	penicillin binding
C5099_RS07295	COG0799	negative regulation of ribosome biogenesis
C5099_RS07300	COG0406	alpha-ribazole phosphatase activity
C5099_RS07310	COG1466	dna polymerase III delta subunit
C5099_RS07325	COG2888	peptidyl-tyrosine sulfation
C5099_RS07335	COG1126	abc transporter atp-binding protein
C5099_RS07340	COG0765	amino acid transport
C5099_RS07345	COG0765	amino acid transport
C5099_RS07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS07360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C5099_RS07365	COG4535	Mg2 and Co2 transporter CorC
C5099_RS07375	COG1702	phosphate starvation-inducible protein PhoH
C5099_RS07385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5099_RS07430	COG0367	asparagine synthase
C5099_RS07440	COG0647	UMP catabolic process
C5099_RS07445	COG1940	carbohydrate kinase activity
C5099_RS07445	COG1846	Transcriptional regulator
C5099_RS07450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5099_RS07460	COG2190	(PTS) system
C5099_RS07460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS07460	COG1263	PTS System
C5099_RS07480	COG0735	belongs to the Fur family
C5099_RS07490	COG0716	FMN binding
C5099_RS07500	COG0596	Alpha beta hydrolase
C5099_RS07505	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C5099_RS07510	COG0033	Phosphoglucomutase
C5099_RS07515	COG0531	amino acid
C5099_RS07520	COG1982	Orn Lys Arg decarboxylase major
C5099_RS07540	COG0745	RESPONSE REGULATOR receiver
C5099_RS07545	COG2205	protein histidine kinase activity
C5099_RS07575	COG3272	Protein of unknown function (DUF1722)
C5099_RS07580	COG0415	Belongs to the DNA photolyase family
C5099_RS07590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5099_RS07595	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5099_RS07600	COG1984	allophanate hydrolase subunit 2
C5099_RS07615	COG3180	Ammonia monooxygenase
C5099_RS07620	COG3539	Fimbrial protein
C5099_RS07625	COG0372	Belongs to the citrate synthase family
C5099_RS07640	COG2009	succinate dehydrogenase
C5099_RS07645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C5099_RS07650	COG1053	succinate dehydrogenase
C5099_RS07655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5099_RS07660	COG0567	Dehydrogenase, E1 component
C5099_RS07665	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5099_RS07675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5099_RS07680	COG2188	Transcriptional regulator
C5099_RS07685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS07685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS07685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS07690	COG0383	alpha-mannosidase activity
C5099_RS07700	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5099_RS07705	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5099_RS07715	COG1228	amidohydrolase
C5099_RS07720	COG0010	Belongs to the arginase family
C5099_RS07725	COG2986	histidine ammonia-lyase
C5099_RS07730	COG0583	DNA-binding transcription factor activity
C5099_RS07735	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C5099_RS07740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5099_RS07740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5099_RS07745	COG1301	dicarboxylic acid transport
C5099_RS07760	COG3799	methylaspartate ammonia-lyase activity
C5099_RS07765	COG4865	methylaspartate mutase activity
C5099_RS07775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C5099_RS07795	COG1271	oxidase subunit
C5099_RS07800	COG1294	oxidase, subunit
C5099_RS07805	COG4890	Cyd operon protein YbgT
C5099_RS07810	COG3790	cyd operon protein YbgE
C5099_RS07815	COG0824	Thioesterase
C5099_RS07820	COG0811	peptide transport
C5099_RS07825	COG0848	biopolymer transport protein
C5099_RS07830	COG3064	Membrane
C5099_RS07840	COG2885	chlorophyll binding
C5099_RS07845	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C5099_RS07890	COG3201	nicotinamide mononucleotide transporter
C5099_RS07895	COG1230	cation diffusion facilitator family transporter
C5099_RS07910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5099_RS07920	COG2017	converts alpha-aldose to the beta-anomer
C5099_RS07930	COG1085	galactose-1-phosphate uridylyltransferase
C5099_RS07935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5099_RS07940	COG1119	ATPase activity
C5099_RS07950	COG3585	molybdate ion transport
C5099_RS07950	COG2005	Transcriptional regulator
C5099_RS07965	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5099_RS07970	COG4149	molybdate abc transporter
C5099_RS07975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C5099_RS07980	COG0561	phosphatase activity
C5099_RS07990	COG0583	DNA-binding transcription factor activity
C5099_RS07995	COG2828	Protein conserved in bacteria
C5099_RS08000	COG0471	metal ion transport
C5099_RS08005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5099_RS08010	COG4677	pectinesterase activity
C5099_RS08015	COG1881	PFAM PEBP family protein
C5099_RS08025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5099_RS08040	COG2226	methyltransferase
C5099_RS08045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5099_RS08055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5099_RS08065	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5099_RS08075	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C5099_RS08080	COG0314	molybdopterin synthase activity
C5099_RS08085	COG0670	Belongs to the BI1 family
C5099_RS08090	COG0670	Belongs to the BI1 family
C5099_RS08095	COG0392	lysyltransferase activity
C5099_RS08100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5099_RS08105	COG3568	Endonuclease Exonuclease Phosphatase
C5099_RS08115	COG0842	Transport permease protein
C5099_RS08120	COG0842	Transport permease protein
C5099_RS08125	COG1131	(ABC) transporter
C5099_RS08135	COG1309	transcriptional regulator
C5099_RS08140	COG0513	Belongs to the DEAD box helicase family
C5099_RS08150	COG1199	ATP-dependent helicase activity
C5099_RS08155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5099_RS08160	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C5099_RS08170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5099_RS08175	COG3128	pkhd-type hydroxylase
C5099_RS08195	COG0668	transmembrane transport
C5099_RS08200	COG1126	abc transporter atp-binding protein
C5099_RS08205	COG0765	amino acid transport
C5099_RS08210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS08225	COG5006	permease, DMT superfamily
C5099_RS08230	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C5099_RS08235	COG2194	sulfuric ester hydrolase activity
C5099_RS08250	COG1321	iron dependent repressor
C5099_RS08255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5099_RS08260	COG1376	ErfK ybiS ycfS ynhG family protein
C5099_RS08265	COG0488	(ABC) transporter
C5099_RS08270	COG0561	phosphatase activity
C5099_RS08275	COG1882	Formate acetyltransferase
C5099_RS08280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5099_RS08285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5099_RS08290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5099_RS08295	COG0303	'Molybdopterin
C5099_RS08300	COG1446	asparaginase
C5099_RS08330	COG2199	diguanylate cyclase activity
C5099_RS08345	COG2133	pyrroloquinoline quinone binding
C5099_RS08350	COG0625	glutathione transferase activity
C5099_RS08355	COG1686	Belongs to the peptidase S11 family
C5099_RS08360	COG1349	DNA-binding transcription factor activity
C5099_RS08365	COG0671	phosphoesterase, PA-phosphatase related
C5099_RS08370	COG2814	Major facilitator Superfamily
C5099_RS08380	COG0561	phosphatase activity
C5099_RS08385	COG0738	Major facilitator superfamily
C5099_RS08390	COG3226	Transcriptional regulator
C5099_RS08405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5099_RS08415	COG0778	Nitroreductase
C5099_RS08435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C5099_RS08440	COG3842	ATPase activity
C5099_RS08445	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5099_RS08450	COG1177	transmembrane transport
C5099_RS08465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS08470	COG4160	amino acid transport
C5099_RS08475	COG4215	(ABC) transporter
C5099_RS08480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS08485	COG1126	abc transporter atp-binding protein
C5099_RS08500	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5099_RS08505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5099_RS08510	COG0702	epimerase
C5099_RS08515	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C5099_RS08520	COG0028	Belongs to the TPP enzyme family
C5099_RS08525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5099_RS08535	COG2431	L-lysine efflux transmembrane transporter activity
C5099_RS08550	COG3593	DNA synthesis involved in DNA repair
C5099_RS08555	COG2990	Protein conserved in bacteria
C5099_RS08560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5099_RS08570	COG1278	Cold shock
C5099_RS08580	COG0542	response to heat
C5099_RS08605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C5099_RS08610	COG4988	ABC transporter
C5099_RS08615	COG0492	ferredoxin-NADP+ reductase activity
C5099_RS08625	COG1522	sequence-specific DNA binding
C5099_RS08640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5099_RS08650	COG0243	molybdopterin cofactor binding
C5099_RS08655	COG0437	4 iron, 4 sulfur cluster binding
C5099_RS08660	COG3302	dmso reductase anchor subunit
C5099_RS08665	COG1335	isochorismatase
C5099_RS08675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C5099_RS08680	COG1882	Formate acetyltransferase
C5099_RS08685	COG2116	formate transmembrane transporter activity
C5099_RS08690	COG1944	ATP diphosphatase activity
C5099_RS08695	COG2323	membrane
C5099_RS08710	COG0501	Belongs to the peptidase M48B family
C5099_RS08720	COG0539	negative regulation of cytoplasmic translation
C5099_RS08730	COG2333	competence protein COMEC
C5099_RS08730	COG0658	competence protein
C5099_RS08745	COG3214	Protein conserved in bacteria
C5099_RS08760	COG3173	Aminoglycoside phosphotransferase
C5099_RS08765	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C5099_RS08770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5099_RS08780	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C5099_RS08790	COG2989	Protein conserved in bacteria
C5099_RS08805	COG3108	Peptidase M15
C5099_RS08810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5099_RS08815	COG1448	Aminotransferase
C5099_RS08835	COG0308	aminopeptidase N
C5099_RS08845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5099_RS08855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5099_RS08860	COG0431	NADPH-dependent FMN reductase
C5099_RS08880	COG0633	Ferredoxin
C5099_RS08880	COG3217	Mosc domain protein beta barrel domain protein
C5099_RS08890	COG0488	(ABC) transporter
C5099_RS08895	COG2995	paraquat-inducible protein a
C5099_RS08900	COG3008	intermembrane lipid transfer
C5099_RS08900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5099_RS08905	COG3009	Protein conserved in bacteria
C5099_RS08910	COG3130	regulation of translation
C5099_RS08920	COG1067	ATP-dependent peptidase activity
C5099_RS08945	COG3070	regulator of competence-specific genes
C5099_RS08950	COG1289	transmembrane transporter activity
C5099_RS08955	COG3304	Inner membrane component domain
C5099_RS08960	COG0210	DNA helicase
C5099_RS08975	COG1832	CoA-binding protein
C5099_RS08990	COG1254	Belongs to the acylphosphatase family
C5099_RS08995	COG2920	part of a sulfur-relay system
C5099_RS09000	COG0670	Belongs to the BI1 family
C5099_RS09010	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C5099_RS09015	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C5099_RS09020	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C5099_RS09025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C5099_RS09030	COG1999	signal sequence binding
C5099_RS09035	COG1773	rubredoxin
C5099_RS09040	COG1271	oxidase subunit
C5099_RS09045	COG1294	oxidase, subunit
C5099_RS09060	COG0489	protein tyrosine kinase activity
C5099_RS09060	COG3206	protein involved in exopolysaccharide biosynthesis
C5099_RS09065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5099_RS09070	COG1596	polysaccharide export
C5099_RS09075	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5099_RS09095	COG1278	Cold shock
C5099_RS09100	COG1278	Cold shock
C5099_RS09120	COG0348	domain, Protein
C5099_RS09125	COG2205	protein histidine kinase activity
C5099_RS09125	COG2198	Histidine kinase
C5099_RS09125	COG0784	Response regulator, receiver
C5099_RS09130	COG1879	ABC-type sugar transport system periplasmic component
C5099_RS09135	COG0745	RESPONSE REGULATOR receiver
C5099_RS09140	COG3005	denitrification pathway
C5099_RS09145	COG0243	molybdopterin cofactor binding
C5099_RS09185	COG3729	General stress protein
C5099_RS09190	COG2233	PERMEase
C5099_RS09225	COG1309	transcriptional regulator
C5099_RS09230	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5099_RS09230	COG0506	proline dehydrogenase activity
C5099_RS09230	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5099_RS09245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5099_RS09270	COG1702	phosphate starvation-inducible protein PhoH
C5099_RS09295	COG3381	protein complex oligomerization
C5099_RS09305	COG1462	curli production assembly transport component CsgG
C5099_RS09320	COG2197	response regulator
C5099_RS09355	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C5099_RS09360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5099_RS09385	COG2943	transferase activity, transferring hexosyl groups
C5099_RS09390	COG5645	(Lipo)protein
C5099_RS09405	COG1560	Kdo2-lipid A biosynthetic process
C5099_RS09415	COG2353	YceI-like domain
C5099_RS09420	COG3038	cytochrome b561
C5099_RS09460	COG2999	glutathione oxidoreductase activity
C5099_RS09470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5099_RS09480	COG0673	inositol 2-dehydrogenase activity
C5099_RS09485	COG0728	peptidoglycan biosynthetic process
C5099_RS09490	COG3418	PFAM FlgN family protein
C5099_RS09495	COG2747	anti-sigma28 factor FlgM
C5099_RS09500	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C5099_RS09505	COG1815	bacterial-type flagellum-dependent cell motility
C5099_RS09510	COG1558	bacterial-type flagellum-dependent cell motility
C5099_RS09515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5099_RS09520	COG1749	Flagellar hook protein flgE
C5099_RS09525	COG4787	bacterial-type flagellum-dependent cell motility
C5099_RS09530	COG4786	Flagellar basal body rod
C5099_RS09545	COG3951	Flagellar rod assembly protein muramidase FlgJ
C5099_RS09545	COG1705	Flagellar rod assembly protein muramidase FlgJ
C5099_RS09550	COG1256	bacterial-type flagellum assembly
C5099_RS09555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5099_RS09570	COG1530	ribonuclease E activity
C5099_RS09580	COG0564	pseudouridine synthase activity
C5099_RS09585	COG0424	maF-like protein
C5099_RS09590	COG1399	metal-binding, possibly nucleic acid-binding protein
C5099_RS09610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5099_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS09625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5099_RS09630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5099_RS09635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5099_RS09645	COG0470	DNA polymerase III
C5099_RS09650	COG0084	hydrolase, TatD family'
C5099_RS09655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS09655	COG1263	PTS System
C5099_RS09660	COG4773	Receptor
C5099_RS09665	COG0537	adenosine 5'-monophosphoramidase activity
C5099_RS09670	COG5633	Lipoprotein
C5099_RS09675	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C5099_RS09680	COG0510	thiamine kinase activity
C5099_RS09695	COG1252	NADH dehydrogenase
C5099_RS09705	COG3134	Outer membrane lipoprotein
C5099_RS09710	COG1309	transcriptional regulator
C5099_RS09720	COG1388	LysM domain
C5099_RS09720	COG1376	ErfK ybiS ycfS ynhG family protein
C5099_RS09725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5099_RS09730	COG4763	Acyl-transferase
C5099_RS09735	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5099_RS09745	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5099_RS09755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5099_RS09760	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5099_RS09770	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C5099_RS09775	COG1177	transmembrane transport
C5099_RS09780	COG0582	viral genome integration into host DNA
C5099_RS09790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5099_RS09825	COG1396	sequence-specific DNA binding
C5099_RS09845	COG1846	Transcriptional regulator
C5099_RS09880	COG1403	HNH endonuclease
C5099_RS09885	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C5099_RS09890	COG0484	heat shock protein binding
C5099_RS09945	COG3772	lysozyme
C5099_RS09980	COG0740	serine-type endopeptidase activity
C5099_RS10055	COG5301	cellulose 1,4-beta-cellobiosidase activity
C5099_RS10100	COG3842	ATPase activity
C5099_RS10115	COG2850	peptidyl-arginine hydroxylation
C5099_RS10120	COG2205	protein histidine kinase activity
C5099_RS10130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5099_RS10155	COG0538	isocitrate dehydrogenase activity
C5099_RS10160	COG5562	phage envelope protein
C5099_RS10165	COG0789	Transcriptional regulator
C5099_RS10170	COG2200	EAL domain
C5099_RS10195	COG2200	EAL domain
C5099_RS10260	COG2894	cell division
C5099_RS10295	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5099_RS10310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5099_RS10315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5099_RS10335	COG2719	SpoVR family
C5099_RS10345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5099_RS10355	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5099_RS10365	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C5099_RS10380	COG0157	Belongs to the NadC ModD family
C5099_RS10385	COG0500	methyltransferase
C5099_RS10390	COG1120	ATPase activity
C5099_RS10400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5099_RS10415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5099_RS10415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS10415	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C5099_RS10420	COG1461	Dihydroxyacetone kinase
C5099_RS10425	COG2376	Dihydroxyacetone kinase
C5099_RS10430	COG3284	Transcriptional regulator
C5099_RS10505	COG3423	Transcriptional regulator
C5099_RS10525	COG2003	Belongs to the UPF0758 family
C5099_RS10530	COG4974	Belongs to the 'phage' integrase family
C5099_RS10560	COG5290	Psort location Cytoplasmic, score
C5099_RS10570	COG4974	Belongs to the 'phage' integrase family
C5099_RS10580	COG0515	serine threonine protein kinase
C5099_RS10580	COG2815	serine threonine protein kinase
C5099_RS10585	COG0582	viral genome integration into host DNA
C5099_RS10590	COG0012	GTP binding
C5099_RS10615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5099_RS10625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5099_RS10645	COG2890	protein-(glutamine-N5) methyltransferase activity
C5099_RS10650	COG3094	Invasion gene expression up-regulator, SirB
C5099_RS10655	COG2912	Transglutaminase-like superfamily
C5099_RS10680	COG0387	Pfam Sodium calcium exchanger
C5099_RS10685	COG4572	Cation transport regulator
C5099_RS10695	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C5099_RS10700	COG4932	domain protein
C5099_RS10705	COG2197	response regulator
C5099_RS10710	COG3850	Histidine kinase
C5099_RS10720	COG2223	nitrite transmembrane transporter activity
C5099_RS10725	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C5099_RS10730	COG1140	nitrate reductase beta subunit
C5099_RS10735	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C5099_RS10740	COG2181	nitrate reductase activity
C5099_RS10745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5099_RS10750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5099_RS10790	COG0788	formyltetrahydrofolate deformylase activity
C5099_RS10800	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5099_RS10805	COG0745	RESPONSE REGULATOR receiver
C5099_RS10810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5099_RS10820	COG1435	thymidine kinase activity
C5099_RS10830	COG1454	alcohol dehydrogenase
C5099_RS10830	COG1012	belongs to the aldehyde dehydrogenase family
C5099_RS10835	COG2095	MarC family integral membrane protein
C5099_RS10840	COG4166	transmembrane transport
C5099_RS10845	COG0601	transmembrane transport
C5099_RS10850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5099_RS10855	COG0444	Belongs to the ABC transporter superfamily
C5099_RS10860	COG4608	Belongs to the ABC transporter superfamily
C5099_RS10880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5099_RS10885	COG2350	Protein conserved in bacteria
C5099_RS10895	COG1607	acyl-coa hydrolase
C5099_RS10915	COG3047	cAMP biosynthetic process
C5099_RS10920	COG0159	tryptophan synthase activity
C5099_RS10930	COG0135	phosphoribosylanthranilate isomerase activity
C5099_RS10930	COG0134	indole-3-glycerol-phosphate synthase activity
C5099_RS10935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5099_RS10935	COG0512	Glutamine amidotransferase of anthranilate synthase
C5099_RS10940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5099_RS10950	COG0613	PHP domain protein
C5099_RS10955	COG0009	L-threonylcarbamoyladenylate synthase
C5099_RS10960	COG4907	membrane protein (DUF2207)
C5099_RS10965	COG1187	pseudouridine synthase activity
C5099_RS10970	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C5099_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS10980	COG0616	signal peptide processing
C5099_RS10995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5099_RS11005	COG0583	DNA-binding transcription factor activity
C5099_RS11025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5099_RS11035	COG0671	phosphoesterase, PA-phosphatase related
C5099_RS11040	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C5099_RS11045	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C5099_RS11055	COG0023	Translation Initiation Factor
C5099_RS11065	COG1349	DNA-binding transcription factor activity
C5099_RS11075	COG5001	Diguanylate cyclase
C5099_RS11090	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5099_RS11090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5099_RS11095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5099_RS11105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5099_RS11120	COG2814	Major facilitator Superfamily
C5099_RS11125	COG4172	Belongs to the ABC transporter superfamily
C5099_RS11130	COG4172	Belongs to the ABC transporter superfamily
C5099_RS11135	COG4171	peptide transport system, permease
C5099_RS11140	COG4168	peptide transport system, permease
C5099_RS11145	COG4166	transmembrane transport
C5099_RS11165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C5099_RS11170	COG1842	Phage shock protein A
C5099_RS11180	COG1983	PspC domain protein
C5099_RS11195	COG0366	Alpha amylase catalytic
C5099_RS11200	COG1653	transport
C5099_RS11205	COG1175	transmembrane transport
C5099_RS11210	COG0395	ABC-type sugar transport system, permease component
C5099_RS11215	COG1063	alcohol dehydrogenase
C5099_RS11220	COG1082	Xylose isomerase domain protein TIM barrel
C5099_RS11225	COG0673	inositol 2-dehydrogenase activity
C5099_RS11230	COG1554	hydrolase, family 65, central catalytic
C5099_RS11235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5099_RS11250	COG1609	Transcriptional regulator
C5099_RS11255	COG3106	COG3106 Predicted ATPase
C5099_RS11265	COG3283	Transcriptional regulator of aromatic amino acids metabolism
C5099_RS11270	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C5099_RS11275	COG4948	Mandelate Racemase Muconate Lactonizing
C5099_RS11280	COG2866	Carboxypeptidase
C5099_RS11285	COG0702	epimerase
C5099_RS11290	COG1073	alpha beta
C5099_RS11295	COG0583	DNA-binding transcription factor activity
C5099_RS11300	COG4166	transmembrane transport
C5099_RS11305	COG0668	transmembrane transport
C5099_RS11310	COG3182	Iron-regulated membrane protein
C5099_RS11315	COG0589	response to stress
C5099_RS11320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5099_RS11330	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C5099_RS11340	COG2207	Transcriptional regulator
C5099_RS11355	COG2840	Smr protein MutS2
C5099_RS11360	COG3706	GGDEF domain
C5099_RS11375	COG0513	Belongs to the DEAD box helicase family
C5099_RS11385	COG0582	viral genome integration into host DNA
C5099_RS11405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5099_RS11410	COG0589	response to stress
C5099_RS11415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C5099_RS11420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5099_RS11420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5099_RS11420	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5099_RS11420	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5099_RS11425	COG3042	response to heat
C5099_RS11430	COG3187	Heat shock protein
C5099_RS11435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5099_RS11440	COG2911	Protein conserved in bacteria
C5099_RS11450	COG3784	Protein of unknown function (DUF1318)
C5099_RS11460	COG0667	Aldo Keto reductase
C5099_RS11470	COG1643	Atp-dependent helicase
C5099_RS11475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C5099_RS11480	COG1012	belongs to the aldehyde dehydrogenase family
C5099_RS11485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5099_RS11490	COG3038	cytochrome b561
C5099_RS11505	COG0840	transmembrane signaling receptor activity
C5099_RS11510	COG0583	DNA-binding transcription factor activity
C5099_RS11515	COG5383	Protein conserved in bacteria
C5099_RS11535	COG2841	Protein conserved in bacteria
C5099_RS11540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5099_RS11545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5099_RS11550	COG1275	C4-dicarboxylate transporter malic acid transport protein
C5099_RS11555	COG0500	methyltransferase
C5099_RS11565	COG3135	benzoate transporter
C5099_RS11570	COG1396	sequence-specific DNA binding
C5099_RS11575	COG0826	peptidase U32
C5099_RS11590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5099_RS11595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C5099_RS11600	COG3842	ATPase activity
C5099_RS11605	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5099_RS11610	COG1177	transmembrane transport
C5099_RS11640	COG3238	Protein conserved in bacteria
C5099_RS11645	COG1247	-acetyltransferase
C5099_RS11665	COG4772	TonB-dependent receptor
C5099_RS11680	COG3391	amine dehydrogenase activity
C5099_RS11685	COG1113	amino acid transport
C5099_RS11715	COG3209	COG3209 Rhs family protein
C5099_RS11740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5099_RS11745	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C5099_RS11750	COG0384	phenazine biosynthesis protein PhzF
C5099_RS11755	COG2181	nitrate reductase activity
C5099_RS11760	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C5099_RS11765	COG1140	nitrate reductase beta subunit
C5099_RS11770	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C5099_RS11775	COG2223	nitrite transmembrane transporter activity
C5099_RS11780	COG0697	spore germination
C5099_RS11785	COG3383	formate dehydrogenase (NAD+) activity
C5099_RS11785	COG0243	molybdopterin cofactor binding
C5099_RS11790	COG0243	molybdopterin cofactor binding
C5099_RS11790	COG3383	formate dehydrogenase (NAD+) activity
C5099_RS11795	COG0437	4 iron, 4 sulfur cluster binding
C5099_RS11800	COG2864	formate dehydrogenase
C5099_RS11805	COG3093	addiction module antidote protein HigA
C5099_RS11810	COG1064	alcohol dehydrogenase
C5099_RS11835	COG1764	response to oxidative stress
C5099_RS11840	COG2200	EAL domain
C5099_RS11840	COG2199	diguanylate cyclase activity
C5099_RS11840	COG2202	Pas domain
C5099_RS11845	COG3706	GGDEF domain
C5099_RS11845	COG3706	GGDEF domain
C5099_RS11850	COG1649	PFAM Uncharacterised BCR, COG1649
C5099_RS11855	COG0531	amino acid
C5099_RS11860	COG0076	glutamate decarboxylase activity
C5099_RS11870	COG0641	radical SAM
C5099_RS11875	COG3119	arylsulfatase activity
C5099_RS11890	COG0243	molybdopterin cofactor binding
C5099_RS11895	COG3539	Fimbrial protein
C5099_RS11900	COG3539	Fimbrial protein
C5099_RS11905	COG3539	Fimbrial protein
C5099_RS11910	COG3188	usher protein
C5099_RS11920	COG3539	Fimbrial protein
C5099_RS11930	COG4977	sequence-specific DNA binding
C5099_RS11940	COG3550	peptidyl-serine autophosphorylation
C5099_RS11945	COG1396	sequence-specific DNA binding
C5099_RS11950	COG4106	trans-aconitate 2-methyltransferase activity
C5099_RS11955	COG3781	membrane
C5099_RS11975	COG2199	diguanylate cyclase activity
C5099_RS11990	COG2066	Belongs to the glutaminase family
C5099_RS11995	COG1012	belongs to the aldehyde dehydrogenase family
C5099_RS12000	COG0583	DNA-binding transcription factor activity
C5099_RS12020	COG1846	Transcriptional regulator
C5099_RS12025	COG4977	sequence-specific DNA binding
C5099_RS12040	COG2814	Major facilitator Superfamily
C5099_RS12050	COG3706	GGDEF domain
C5099_RS12055	COG3111	PFAM Bacterial OB fold (BOF) protein
C5099_RS12065	COG0339	signal peptide processing
C5099_RS12075	COG4221	oxidoreductase activity
C5099_RS12080	COG1802	Transcriptional regulator
C5099_RS12090	COG0246	Mannitol dehydrogenase
C5099_RS12095	COG0477	Major facilitator Superfamily
C5099_RS12100	COG1063	alcohol dehydrogenase
C5099_RS12105	COG4948	Mandelate Racemase Muconate Lactonizing
C5099_RS12125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5099_RS12145	COG3381	protein complex oligomerization
C5099_RS12155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5099_RS12160	COG1940	carbohydrate kinase activity
C5099_RS12165	COG0583	DNA-binding transcription factor activity
C5099_RS12170	COG2814	Major facilitator Superfamily
C5099_RS12190	COG3591	Belongs to the peptidase S1B family
C5099_RS12210	COG0628	permease
C5099_RS12215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C5099_RS12220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C5099_RS12235	COG0531	amino acid
C5099_RS12245	COG3136	membrane protein required for alginate biosynthesis
C5099_RS12250	COG0745	RESPONSE REGULATOR receiver
C5099_RS12265	COG0114	fumarate hydratase activity
C5099_RS12270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5099_RS12270	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5099_RS12275	COG1482	cell wall glycoprotein biosynthetic process
C5099_RS12280	COG5339	Protein conserved in bacteria
C5099_RS12305	COG3250	beta-galactosidase activity
C5099_RS12310	COG1309	transcriptional regulator
C5099_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS12320	COG1609	Transcriptional regulator
C5099_RS12325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS12325	COG1263	PTS System
C5099_RS12330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5099_RS12340	COG0673	inositol 2-dehydrogenase activity
C5099_RS12385	COG4659	FMN binding
C5099_RS12395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5099_RS12405	COG3104	oligopeptide transport
C5099_RS12410	COG0625	glutathione transferase activity
C5099_RS12430	COG3895	Periplasmic Protein
C5099_RS12440	COG3133	Outer membrane lipoprotein
C5099_RS12455	COG1566	PFAM secretion protein HlyD family protein
C5099_RS12460	COG1289	transmembrane transporter activity
C5099_RS12465	COG2032	superoxide dismutase activity
C5099_RS12470	COG4989	oxidoreductase activity
C5099_RS12475	COG3313	Fe-S protein
C5099_RS12480	COG1309	transcriptional regulator
C5099_RS12485	COG1902	pentaerythritol trinitrate reductase activity
C5099_RS12490	COG0346	lactoylglutathione lyase activity
C5099_RS12510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C5099_RS12515	COG0791	NLP P60 protein
C5099_RS12520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5099_RS12525	COG2814	Major facilitator Superfamily
C5099_RS12545	COG0583	DNA-binding transcription factor activity
C5099_RS12550	COG2814	Major facilitator Superfamily
C5099_RS12555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5099_RS12560	COG0307	riboflavin synthase, alpha
C5099_RS12570	COG3468	outer membrane autotransporter barrel domain protein
C5099_RS12590	COG4529	Protein conserved in bacteria
C5099_RS12600	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C5099_RS12605	COG0437	4 iron, 4 sulfur cluster binding
C5099_RS12615	COG2414	aldehyde ferredoxin oxidoreductase
C5099_RS12620	COG0437	4 iron, 4 sulfur cluster binding
C5099_RS12630	COG0469	pyruvate kinase activity
C5099_RS12635	COG4238	major outer membrane lipoprotein
C5099_RS12640	COG1376	ErfK ybiS ycfS ynhG family protein
C5099_RS12655	COG0719	Fe-S assembly protein
C5099_RS12660	COG0396	ATPase activity
C5099_RS12665	COG0719	Fe-S assembly protein
C5099_RS12670	COG0316	Belongs to the HesB IscA family
C5099_RS12680	COG2050	protein possibly involved in aromatic compounds catabolism
C5099_RS12705	COG0738	Major facilitator superfamily
C5099_RS12710	COG2271	Major facilitator Superfamily
C5099_RS12725	COG4670	ketone body catabolic process
C5099_RS12730	COG1960	acyl-CoA dehydrogenase activity
C5099_RS12735	COG1917	Cupin 2, conserved barrel domain protein
C5099_RS12735	COG2207	Transcriptional regulator
C5099_RS12745	COG2086	electron transfer activity
C5099_RS12750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5099_RS12755	COG0644	oxidoreductase
C5099_RS12760	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C5099_RS12765	COG0318	PFAM AMP-dependent synthetase and ligase
C5099_RS12770	COG0574	Belongs to the PEP-utilizing enzyme family
C5099_RS12770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5099_RS12785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5099_RS12790	COG4256	Hemin uptake protein
C5099_RS12800	COG2200	EAL domain
C5099_RS12805	COG0791	NLP P60 protein
C5099_RS12815	COG0386	Belongs to the glutathione peroxidase family
C5099_RS12875	COG3137	Salt-induced outer membrane protein
C5099_RS12880	COG1105	Belongs to the carbohydrate kinase PfkB family
C5099_RS12890	COG3001	Fructosamine kinase
C5099_RS12900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5099_RS12905	COG1988	membrane-bound metal-dependent
C5099_RS12910	COG1823	symporter activity
C5099_RS12920	COG0753	catalase activity
C5099_RS12925	COG3394	polysaccharide catabolic process
C5099_RS12930	COG1486	melibiose metabolic process
C5099_RS12935	COG2169	Transcriptional regulator
C5099_RS12935	COG1917	Cupin 2, conserved barrel domain protein
C5099_RS12940	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5099_RS12945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5099_RS12950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5099_RS12960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5099_RS12970	COG0322	excinuclease ABC activity
C5099_RS12980	COG3678	ATP-independent chaperone mediated protein folding
C5099_RS13015	COG0708	Exodeoxyribonuclease III
C5099_RS13020	COG0398	Pfam SNARE associated Golgi protein
C5099_RS13030	COG0398	Pfam SNARE associated Golgi protein
C5099_RS13040	COG4134	Bacterial extracellular solute-binding protein
C5099_RS13045	COG4135	transport system, permease component
C5099_RS13050	COG4136	ATPase activity
C5099_RS13055	COG2897	thiosulfate sulfurtransferase activity
C5099_RS13060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5099_RS13065	COG0494	nUDIX hydrolase
C5099_RS13075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5099_RS13090	COG0443	Heat shock 70 kDa protein
C5099_RS13095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5099_RS13100	COG0709	Synthesizes selenophosphate from selenide and ATP
C5099_RS13110	COG0778	Nitroreductase
C5099_RS13120	COG0616	signal peptide processing
C5099_RS13125	COG0252	asparaginase activity
C5099_RS13130	COG1335	isochorismatase
C5099_RS13135	COG2814	Major facilitator Superfamily
C5099_RS13140	COG1349	DNA-binding transcription factor activity
C5099_RS13145	COG0667	Aldo Keto reductase
C5099_RS13150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS13155	COG0191	fructose-bisphosphate aldolase activity
C5099_RS13160	COG1063	alcohol dehydrogenase
C5099_RS13165	COG2271	Major facilitator Superfamily
C5099_RS13170	COG1063	alcohol dehydrogenase
C5099_RS13175	COG3139	Protein of unknown function (DUF1315)
C5099_RS13185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5099_RS13190	COG0676	glucose-6-phosphate 1-epimerase activity
C5099_RS13195	COG0656	L-ascorbic acid biosynthetic process
C5099_RS13200	COG3713	MltA-interacting MipA family protein
C5099_RS13205	COG2766	serine protein kinase
C5099_RS13215	COG2199	diguanylate cyclase activity
C5099_RS13220	COG2199	diguanylate cyclase activity
C5099_RS13225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5099_RS13240	COG2207	Transcriptional regulator
C5099_RS13245	COG2807	transmembrane transport
C5099_RS13250	COG3189	MarR family transcriptional regulator
C5099_RS13255	COG3042	response to heat
C5099_RS13260	COG2199	diguanylate cyclase activity
C5099_RS13260	COG2203	Gaf domain
C5099_RS13275	COG2261	transglycosylase associated protein
C5099_RS13285	COG3615	Tellurite resistance protein tehB
C5099_RS13300	COG0473	3-isopropylmalate dehydrogenase activity
C5099_RS13305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C5099_RS13310	COG0318	PFAM AMP-dependent synthetase and ligase
C5099_RS13315	COG3065	identical protein binding
C5099_RS13320	COG1214	PFAM Peptidase M22, glycoprotease
C5099_RS13325	COG1199	ATP-dependent helicase activity
C5099_RS13330	COG0251	oxidation-reduction process
C5099_RS13345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5099_RS13355	COG1760	l-serine dehydratase
C5099_RS13360	COG2200	EAL domain
C5099_RS13365	COG1253	flavin adenine dinucleotide binding
C5099_RS13380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS13380	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS13385	COG3715	PTS system
C5099_RS13390	COG3716	PTS system mannose fructose sorbose family IID component
C5099_RS13410	COG2226	methyltransferase
C5099_RS13445	COG1414	Transcriptional regulator
C5099_RS13450	COG2814	Major facilitator Superfamily
C5099_RS13460	COG0793	Belongs to the peptidase S41A family
C5099_RS13470	COG1956	GAF domain-containing protein
C5099_RS13480	COG3008	intermembrane lipid transfer
C5099_RS13500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5099_RS13510	COG1276	copper resistance
C5099_RS13515	COG2372	response to copper ion
C5099_RS13525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5099_RS13530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5099_RS13535	COG1770	oligopeptidase
C5099_RS13540	COG2979	Protein of unknown function (DUF533)
C5099_RS13550	COG3141	response to X-ray
C5099_RS13560	COG0800	Aldolase
C5099_RS13565	COG0129	dihydroxy-acid dehydratase activity
C5099_RS13570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5099_RS13575	COG1737	Transcriptional regulator
C5099_RS13580	COG0469	pyruvate kinase activity
C5099_RS13585	COG1560	Kdo2-lipid A biosynthetic process
C5099_RS13590	COG0739	heme binding
C5099_RS13595	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C5099_RS13605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5099_RS13635	COG0217	transcriptional regulatory protein
C5099_RS13640	COG0494	nUDIX hydrolase
C5099_RS13650	COG1335	isochorismatase
C5099_RS13655	COG1801	Protein of unknown function DUF72
C5099_RS13660	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C5099_RS13675	COG0243	molybdopterin cofactor binding
C5099_RS13680	COG3005	denitrification pathway
C5099_RS13690	COG3102	Protein conserved in bacteria
C5099_RS13710	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5099_RS13715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5099_RS13720	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C5099_RS13725	COG0745	RESPONSE REGULATOR receiver
C5099_RS13735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5099_RS13745	COG0840	transmembrane signaling receptor activity
C5099_RS13750	COG0835	chemotaxis
C5099_RS13755	COG0643	Histidine kinase
C5099_RS13755	COG2198	Histidine kinase
C5099_RS13760	COG1360	Flagellar Motor Protein
C5099_RS13765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C5099_RS13780	COG0589	response to stress
C5099_RS13790	COG1877	trehalose-phosphatase activity
C5099_RS13795	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5099_RS13805	COG1879	ABC-type sugar transport system periplasmic component
C5099_RS13815	COG1528	Iron-storage protein
C5099_RS13840	COG1528	Iron-storage protein
C5099_RS13850	COG0814	amino acid
C5099_RS13855	COG3318	Belongs to the UPF0149 family
C5099_RS13855	COG3012	SEC-C Motif Domain Protein
C5099_RS13885	COG2197	response regulator
C5099_RS13895	COG2197	response regulator
C5099_RS13900	COG1126	abc transporter atp-binding protein
C5099_RS13905	COG0765	amino acid transport
C5099_RS13915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS13925	COG1191	sigma factor activity
C5099_RS13940	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C5099_RS13945	COG1516	flagellar protein fliS
C5099_RS13955	COG0366	Alpha amylase catalytic
C5099_RS13970	COG2391	methyltransferase activity
C5099_RS13975	COG0425	Belongs to the sulfur carrier protein TusA family
C5099_RS13980	COG2135	peptidase activity
C5099_RS14000	COG2207	Transcriptional regulator
C5099_RS14005	COG1881	PFAM PEBP family protein
C5099_RS14010	COG2076	Multidrug Resistance protein
C5099_RS14025	COG1766	The M ring may be actively involved in energy transduction
C5099_RS14030	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5099_RS14035	COG1317	bacterial-type flagellum organization
C5099_RS14040	COG1157	protein secretion by the type III secretion system
C5099_RS14045	COG2882	bacterial-type flagellum organization
C5099_RS14055	COG1580	Controls the rotational direction of flagella during chemotaxis
C5099_RS14060	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5099_RS14065	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5099_RS14070	COG3190	flagellar
C5099_RS14075	COG1338	Plays a role in the flagellum-specific transport system
C5099_RS14080	COG1987	bacterial-type flagellum assembly
C5099_RS14085	COG1684	flagellar biosynthetic protein fliR
C5099_RS14090	COG2197	response regulator
C5099_RS14120	COG5475	Uncharacterized small protein (DUF2158)
C5099_RS14125	COG2354	Protein conserved in bacteria
C5099_RS14130	COG0697	spore germination
C5099_RS14135	COG3727	T/G mismatch-specific endonuclease activity
C5099_RS14140	COG0270	DNA (cytosine-5-)-methyltransferase activity
C5099_RS14145	COG1418	mRNA catabolic process
C5099_RS14185	COG2205	protein histidine kinase activity
C5099_RS14190	COG0745	RESPONSE REGULATOR receiver
C5099_RS14195	COG2351	hydroxyisourate hydrolase activity
C5099_RS14210	COG3443	Belongs to the bacterial solute-binding protein 9 family
C5099_RS14265	COG5301	cellulose 1,4-beta-cellobiosidase activity
C5099_RS14280	COG2032	superoxide dismutase activity
C5099_RS14380	COG4220	transposase activity
C5099_RS14415	COG3772	lysozyme
C5099_RS14460	COG0484	heat shock protein binding
C5099_RS14465	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C5099_RS14470	COG1403	HNH endonuclease
C5099_RS14530	COG1846	Transcriptional regulator
C5099_RS14540	COG4197	protein conserved in bacteria, prophage-related
C5099_RS14580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5099_RS14625	COG0477	Major facilitator Superfamily
C5099_RS14630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5099_RS14635	COG0217	transcriptional regulatory protein
C5099_RS14655	COG0534	Mate efflux family protein
C5099_RS14665	COG0583	DNA-binding transcription factor activity
C5099_RS14670	COG0583	DNA-binding transcription factor activity
C5099_RS14680	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5099_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS14690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5099_RS14695	COG3775	system Galactitol-specific IIC component
C5099_RS14700	COG3414	Phosphotransferase system galactitol-specific IIB component
C5099_RS14710	COG1349	DNA-binding transcription factor activity
C5099_RS14715	COG0698	ribose 5-phosphate isomerase
C5099_RS14720	COG3775	system Galactitol-specific IIC component
C5099_RS14725	COG3414	Phosphotransferase system galactitol-specific IIB component
C5099_RS14730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS14740	COG1376	ErfK ybiS ycfS ynhG family protein
C5099_RS14755	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C5099_RS14815	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C5099_RS14830	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C5099_RS14840	COG1012	belongs to the aldehyde dehydrogenase family
C5099_RS14845	COG1012	belongs to the aldehyde dehydrogenase family
C5099_RS14845	COG1454	alcohol dehydrogenase
C5099_RS14850	COG4656	Part of a membrane complex involved in electron transport
C5099_RS14875	COG1289	transmembrane transporter activity
C5099_RS14885	COG1686	Belongs to the peptidase S11 family
C5099_RS14890	COG2925	Exonuclease
C5099_RS14895	COG0531	amino acid
C5099_RS14905	COG0583	DNA-binding transcription factor activity
C5099_RS14910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5099_RS14915	COG4115	mRNA cleavage
C5099_RS14920	COG2161	toxin-antitoxin pair type II binding
C5099_RS14940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5099_RS14950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5099_RS14950	COG0131	Imidazoleglycerol-phosphate dehydratase
C5099_RS14955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5099_RS14975	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C5099_RS14980	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5099_RS14985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C5099_RS15055	COG2089	acid synthase
C5099_RS15065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5099_RS15075	COG0438	transferase activity, transferring glycosyl groups
C5099_RS15080	COG2327	Polysaccharide pyruvyl transferase
C5099_RS15085	COG2244	polysaccharide biosynthetic process
C5099_RS15090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5099_RS15095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5099_RS15100	COG0662	Cupin 2, conserved barrel domain protein
C5099_RS15100	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C5099_RS15105	COG0297	glycogen (starch) synthase activity
C5099_RS15110	COG1051	belongs to the nudix hydrolase family
C5099_RS15115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5099_RS15120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C5099_RS15125	COG0110	maltose O-acetyltransferase activity
C5099_RS15130	COG1216	Glycosyl transferase, family 2
C5099_RS15140	COG0438	transferase activity, transferring glycosyl groups
C5099_RS15145	COG1045	serine acetyltransferase
C5099_RS15150	COG0463	Glycosyl transferase, family 2
C5099_RS15155	COG3206	protein involved in exopolysaccharide biosynthesis
C5099_RS15155	COG0489	protein tyrosine kinase activity
C5099_RS15160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5099_RS15165	COG1596	polysaccharide export
C5099_RS15170	COG1253	flavin adenine dinucleotide binding
C5099_RS15175	COG2982	Protein involved in outer membrane biogenesis
C5099_RS15185	COG0572	uridine kinase
C5099_RS15190	COG5001	Diguanylate cyclase
C5099_RS15190	COG5002	protein histidine kinase activity
C5099_RS15190	COG3447	MASE1 domain protein
C5099_RS15195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C5099_RS15205	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C5099_RS15210	COG0631	protein serine/threonine phosphatase activity
C5099_RS15270	COG5301	cellulose 1,4-beta-cellobiosidase activity
C5099_RS15420	COG1030	water channel activity
C5099_RS15440	COG4220	transposase activity
C5099_RS15465	COG3772	lysozyme
C5099_RS15535	COG0582	viral genome integration into host DNA
C5099_RS15560	COG2205	protein histidine kinase activity
C5099_RS15565	COG0745	RESPONSE REGULATOR receiver
C5099_RS15570	COG3422	double-strand break repair
C5099_RS15575	COG0826	peptidase U32
C5099_RS15590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5099_RS15600	COG1070	Carbohydrate kinase
C5099_RS15635	COG1063	alcohol dehydrogenase
C5099_RS15640	COG3775	system Galactitol-specific IIC component
C5099_RS15645	COG3414	Phosphotransferase system galactitol-specific IIB component
C5099_RS15650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS15670	COG1830	Aldolase
C5099_RS15675	COG2211	Major facilitator Superfamily
C5099_RS15680	COG1397	ADP-ribosylglycohydrolase
C5099_RS15685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS15690	COG2188	Transcriptional regulator
C5099_RS15695	COG3757	hydrolase, family 25
C5099_RS15700	COG0351	phosphomethylpyrimidine kinase
C5099_RS15705	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C5099_RS15720	COG5455	response to cobalt ion
C5099_RS15725	COG3539	Fimbrial protein
C5099_RS15730	COG3188	usher protein
C5099_RS15735	COG3121	Chaperone
C5099_RS15740	COG3539	Fimbrial protein
C5099_RS15755	COG0489	protein tyrosine kinase activity
C5099_RS15770	COG3831	ATPase activity
C5099_RS15775	COG3831	ATPase activity
C5099_RS15780	COG3831	ATPase activity
C5099_RS15790	COG0714	Associated with various cellular activities
C5099_RS15795	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C5099_RS15800	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C5099_RS15810	COG4808	Protein conserved in bacteria
C5099_RS15815	COG4807	Protein conserved in bacteria
C5099_RS15820	COG3279	Response regulator of the LytR AlgR family
C5099_RS15825	COG3275	phosphorelay sensor kinase activity
C5099_RS15830	COG0789	Transcriptional regulator
C5099_RS15840	COG1174	glycine betaine transport
C5099_RS15845	COG1125	glycine betaine transport
C5099_RS15850	COG1174	glycine betaine transport
C5099_RS15855	COG1732	Glycine betaine
C5099_RS15860	COG1472	Belongs to the glycosyl hydrolase 3 family
C5099_RS15865	COG0277	FAD linked oxidase domain protein
C5099_RS15870	COG1686	Belongs to the peptidase S11 family
C5099_RS15880	COG0586	Pfam SNARE associated Golgi protein
C5099_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS15890	COG1538	Outer membrane efflux protein
C5099_RS15910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5099_RS15920	COG1346	cytolysis
C5099_RS15930	COG2949	membrane
C5099_RS15940	COG0493	'glutamate synthase
C5099_RS15945	COG0167	dihydroorotate dehydrogenase activity
C5099_RS15945	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C5099_RS15950	COG4211	Belongs to the binding-protein-dependent transport system permease family
C5099_RS15960	COG1879	ABC-type sugar transport system periplasmic component
C5099_RS15965	COG1609	Transcriptional regulator
C5099_RS15975	COG2311	Membrane
C5099_RS15995	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5099_RS16000	COG4771	TonB-dependent receptor
C5099_RS16010	COG0833	amino acid
C5099_RS16020	COG0583	DNA-binding transcription factor activity
C5099_RS16025	COG2855	membrane
C5099_RS16035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS16035	COG1522	sequence-specific DNA binding
C5099_RS16040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5099_RS16050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5099_RS16055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5099_RS16060	COG2313	pseudouridylate synthase activity
C5099_RS16065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS16070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS16070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS16070	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C5099_RS16075	COG1105	Belongs to the carbohydrate kinase PfkB family
C5099_RS16080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS16080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS16085	COG2814	Major facilitator Superfamily
C5099_RS16100	COG0246	Mannitol dehydrogenase
C5099_RS16105	COG0523	cobalamin synthesis protein
C5099_RS16110	COG0671	phosphoesterase, PA-phosphatase related
C5099_RS16115	COG0791	NLP P60 protein
C5099_RS16120	COG2200	EAL domain
C5099_RS16125	COG4166	transmembrane transport
C5099_RS16130	COG4174	ABC transporter (Permease)
C5099_RS16135	COG4239	(ABC) transporter, permease
C5099_RS16140	COG4172	Belongs to the ABC transporter superfamily
C5099_RS16150	COG2814	Major facilitator Superfamily
C5099_RS16155	COG1187	pseudouridine synthase activity
C5099_RS16165	COG1061	Type III restriction enzyme res subunit
C5099_RS16185	COG3083	sulfuric ester hydrolase activity
C5099_RS16205	COG2197	response regulator
C5099_RS16210	COG4235	cytochrome complex assembly
C5099_RS16210	COG3088	subunit of a heme lyase
C5099_RS16215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5099_RS16220	COG1138	Cytochrome C-type biogenesis protein
C5099_RS16230	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5099_RS16235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5099_RS16240	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5099_RS16250	COG3005	denitrification pathway
C5099_RS16255	COG3043	anaerobic respiration
C5099_RS16260	COG0348	domain, Protein
C5099_RS16265	COG0437	4 iron, 4 sulfur cluster binding
C5099_RS16275	COG3062	negative regulation of establishment of protein localization
C5099_RS16280	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS16280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS16295	COG0579	oxidoreductase
C5099_RS16300	COG4615	Cyclic peptide transporter
C5099_RS16310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5099_RS16310	COG2169	Transcriptional regulator
C5099_RS16315	COG1477	protein flavinylation
C5099_RS16335	COG0642	Histidine kinase
C5099_RS16335	COG2198	Histidine kinase
C5099_RS16340	COG2197	response regulator
C5099_RS16345	COG2205	protein histidine kinase activity
C5099_RS16345	COG0784	Response regulator, receiver
C5099_RS16350	COG3852	Histidine kinase
C5099_RS16355	COG2204	response regulator
C5099_RS16360	COG2204	response regulator
C5099_RS16365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5099_RS16370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5099_RS16375	COG2031	fatty acid transporter
C5099_RS16385	COG4676	Protein conserved in bacteria
C5099_RS16390	COG5445	Predicted secreted protein (DUF2300)
C5099_RS16395	COG2373	Large extracellular alpha-helical protein
C5099_RS16400	COG3234	Protein of unknown function (DUF1175)
C5099_RS16405	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
C5099_RS16410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5099_RS16420	COG3468	outer membrane autotransporter barrel domain protein
C5099_RS16425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5099_RS16430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5099_RS16435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5099_RS16440	COG3642	lipopolysaccharide core region biosynthetic process
C5099_RS16445	COG0584	glycerophosphoryl diester phosphodiesterase
C5099_RS16450	COG2271	Major facilitator Superfamily
C5099_RS16455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5099_RS16465	COG0247	lactate metabolic process
C5099_RS16470	COG5464	transposase or invertase
C5099_RS16485	COG2271	Major facilitator Superfamily
C5099_RS16495	COG1414	Transcriptional regulator
C5099_RS16540	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5099_RS16560	COG0318	PFAM AMP-dependent synthetase and ligase
C5099_RS16570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C5099_RS16585	COG1169	isochorismate synthase
C5099_RS16590	COG4575	ribosome binding
C5099_RS16595	COG2153	protein acetylation
C5099_RS16605	COG5160	protein modification by small protein removal
C5099_RS16610	COG2234	aminopeptidase activity
C5099_RS16625	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5099_RS16630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5099_RS16640	COG0839	Belongs to the complex I subunit 6 family
C5099_RS16655	COG1034	ATP synthesis coupled electron transport
C5099_RS16660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5099_RS16665	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C5099_RS16685	COG0583	DNA-binding transcription factor activity
C5099_RS16695	COG0436	Aminotransferase
C5099_RS16705	COG0490	domain, Protein
C5099_RS16705	COG0471	metal ion transport
C5099_RS16710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5099_RS16725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5099_RS16730	COG0857	belongs to the CobB CobQ family
C5099_RS16730	COG0280	phosphate acetyltransferase
C5099_RS16735	COG1288	antiporter activity
C5099_RS16740	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5099_RS16745	COG0622	Phosphoesterase
C5099_RS16750	COG0625	glutathione transferase activity
C5099_RS16755	COG0625	glutathione transferase activity
C5099_RS16760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5099_RS16765	COG1090	epimerase
C5099_RS16770	COG5464	transposase or invertase
C5099_RS16775	COG4598	ABC transporter
C5099_RS16780	COG4160	amino acid transport
C5099_RS16785	COG4215	(ABC) transporter
C5099_RS16790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS16795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS16800	COG0163	prenyltransferase activity
C5099_RS16805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5099_RS16810	COG1286	toxin biosynthetic process
C5099_RS16815	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C5099_RS16820	COG0285	dihydrofolate synthase activity
C5099_RS16830	COG0586	Pfam SNARE associated Golgi protein
C5099_RS16840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5099_RS16850	COG4974	Belongs to the 'phage' integrase family
C5099_RS16925	COG4695	Portal protein
C5099_RS17010	COG5301	cellulose 1,4-beta-cellobiosidase activity
C5099_RS17030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5099_RS17110	COG2814	Major facilitator Superfamily
C5099_RS17115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5099_RS17130	COG3101	peptidyl-lysine hydroxylation
C5099_RS17135	COG0730	response to heat
C5099_RS17170	COG3539	Fimbrial protein
C5099_RS17175	COG3539	Fimbrial protein
C5099_RS17180	COG3539	Fimbrial protein
C5099_RS17185	COG3121	Chaperone
C5099_RS17195	COG2062	phosphohistidine phosphatase, SixA
C5099_RS17210	COG3691	Protein conserved in bacteria
C5099_RS17220	COG2067	long-chain fatty acid transport protein
C5099_RS17235	COG2116	formate transmembrane transporter activity
C5099_RS17260	COG0477	Major facilitator Superfamily
C5099_RS17265	COG1566	PFAM secretion protein HlyD family protein
C5099_RS17270	COG2197	response regulator
C5099_RS17275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS17275	COG0784	Response regulator, receiver
C5099_RS17275	COG2205	protein histidine kinase activity
C5099_RS17275	COG2198	Histidine kinase
C5099_RS17280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5099_RS17285	COG0679	Auxin Efflux Carrier
C5099_RS17290	COG0028	Belongs to the TPP enzyme family
C5099_RS17320	COG1560	Kdo2-lipid A biosynthetic process
C5099_RS17330	COG0436	Aminotransferase
C5099_RS17340	COG3279	Response regulator of the LytR AlgR family
C5099_RS17345	COG2207	Transcriptional regulator
C5099_RS17355	COG1363	Peptidase, m42
C5099_RS17360	COG0006	proline dipeptidase activity
C5099_RS17365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS17370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS17380	COG0038	chloride channel
C5099_RS17395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5099_RS17400	COG2199	diguanylate cyclase activity
C5099_RS17400	COG2200	EAL domain
C5099_RS17415	COG3415	Transposase
C5099_RS17420	COG3415	Transposase
C5099_RS17425	COG0675	Transposase, IS605 OrfB family
C5099_RS17435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5099_RS17460	COG0583	DNA-binding transcription factor activity
C5099_RS17470	COG2211	Major facilitator Superfamily
C5099_RS17475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C5099_RS17485	COG0583	DNA-binding transcription factor activity
C5099_RS17495	COG3530	Putative quorum-sensing-regulated virulence factor
C5099_RS17505	COG3115	cell septum assembly
C5099_RS17515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5099_RS17520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS17525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5099_RS17530	COG2190	(PTS) system
C5099_RS17545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5099_RS17550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C5099_RS17555	COG4208	sulfate ABC transporter
C5099_RS17560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C5099_RS17565	COG4150	thiosulfate binding
C5099_RS17570	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS17580	COG1263	PTS System
C5099_RS17580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS17585	COG2837	iron assimilation
C5099_RS17605	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5099_RS17615	COG2207	Transcriptional regulator
C5099_RS17620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C5099_RS17625	COG4816	utilization protein
C5099_RS17635	COG4303	Ethanolamine ammonia lyase large subunit
C5099_RS17640	COG4819	ethanolamine utilization protein
C5099_RS17645	COG3192	ethanolamine utilization protein
C5099_RS17650	COG1454	alcohol dehydrogenase
C5099_RS17655	COG4820	ethanolamine utilization protein (EutJ)
C5099_RS17660	COG1012	belongs to the aldehyde dehydrogenase family
C5099_RS17665	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C5099_RS17670	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C5099_RS17675	COG0280	phosphate acetyltransferase
C5099_RS17680	COG4812	Cobalamin adenosyltransferase
C5099_RS17685	COG4766	ethanolamine catabolic process
C5099_RS17690	COG4917	ethanolamine utilization protein
C5099_RS17695	COG4810	utilization protein
C5099_RS17700	COG0280	phosphate acetyltransferase
C5099_RS17700	COG0281	malic enzyme
C5099_RS17705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5099_RS17710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5099_RS17715	COG5342	invasion associated locus B
C5099_RS17730	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS17730	COG0493	'glutamate synthase
C5099_RS17735	COG3850	Histidine kinase
C5099_RS17750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5099_RS17760	COG1393	Belongs to the ArsC family
C5099_RS17780	COG0400	carboxylic ester hydrolase activity
C5099_RS17790	COG2321	neutral zinc metallopeptidase
C5099_RS17800	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C5099_RS17810	COG2716	regulation of RNA biosynthetic process
C5099_RS17815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5099_RS17820	COG0628	permease
C5099_RS17825	COG4783	chaperone-mediated protein folding
C5099_RS17830	COG1393	Belongs to the ArsC family
C5099_RS17840	COG2233	PERMEase
C5099_RS17860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5099_RS17865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5099_RS17870	COG0248	Ppx GppA phosphatase
C5099_RS17875	COG2200	EAL domain
C5099_RS17895	COG3133	Outer membrane lipoprotein
C5099_RS17910	COG0516	GMP reductase activity
C5099_RS17910	COG0517	IMP dehydrogenase activity
C5099_RS17935	COG1645	bacterial-type flagellum-dependent swarming motility
C5099_RS17950	COG2976	Protein conserved in bacteria
C5099_RS17985	COG4953	penicillin-binding protein 1C
C5099_RS17990	COG2373	Large extracellular alpha-helical protein
C5099_RS17995	COG2897	thiosulfate sulfurtransferase activity
C5099_RS18020	COG2975	iron-sulfur cluster assembly
C5099_RS18025	COG0633	Ferredoxin
C5099_RS18045	COG0822	iron-sulfur transferase activity
C5099_RS18065	COG0483	inositol monophosphate 1-phosphatase activity
C5099_RS18070	COG1073	alpha beta
C5099_RS18075	COG3711	transcriptional antiterminator
C5099_RS18080	COG2814	Major facilitator Superfamily
C5099_RS18085	COG2259	Doxx family
C5099_RS18090	COG2017	converts alpha-aldose to the beta-anomer
C5099_RS18095	COG1063	alcohol dehydrogenase
C5099_RS18100	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5099_RS18105	COG1129	ABC transporter
C5099_RS18110	COG1879	ABC-type sugar transport system periplasmic component
C5099_RS18115	COG0457	Tetratricopeptide repeat
C5099_RS18120	COG1940	carbohydrate kinase activity
C5099_RS18130	COG1017	nitric oxide dioxygenase activity
C5099_RS18130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5099_RS18135	COG0347	Belongs to the P(II) protein family
C5099_RS18140	COG2204	response regulator
C5099_RS18145	COG3170	Tfp pilus assembly protein FimV
C5099_RS18150	COG2205	protein histidine kinase activity
C5099_RS18155	COG0047	phosphoribosylformylglycinamidine synthase activity
C5099_RS18155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5099_RS18170	COG0560	Phosphoserine phosphatase
C5099_RS18175	COG1737	Transcriptional regulator
C5099_RS18180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS18200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C5099_RS18225	COG0681	Belongs to the peptidase S26 family
C5099_RS18235	COG3086	response to oxidative stress
C5099_RS18240	COG3026	antisigma factor binding
C5099_RS18245	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C5099_RS18250	COG1595	DNA-templated transcription, initiation
C5099_RS18255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5099_RS18265	COG0513	Belongs to the DEAD box helicase family
C5099_RS18270	COG0583	DNA-binding transcription factor activity
C5099_RS18290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5099_RS18300	COG3118	belongs to the thioredoxin family
C5099_RS18305	COG3148	PFAM DTW domain containing protein
C5099_RS18310	COG0045	succinate-CoA ligase (ADP-forming) activity
C5099_RS18310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5099_RS18310	COG1042	CoA-binding domain protein
C5099_RS18315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5099_RS18320	COG5544	Lipoprotein
C5099_RS18325	COG0477	Major facilitator Superfamily
C5099_RS18360	COG0542	response to heat
C5099_RS18370	COG0564	pseudouridine synthase activity
C5099_RS18375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5099_RS18380	COG3385	transposase activity
C5099_RS18390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5099_RS18400	COG0077	Prephenate dehydratase
C5099_RS18400	COG1605	Chorismate mutase
C5099_RS18405	COG0287	Prephenate dehydrogenase
C5099_RS18405	COG1605	Chorismate mutase
C5099_RS18410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5099_RS18425	COG2199	diguanylate cyclase activity
C5099_RS18430	COG2885	chlorophyll binding
C5099_RS18455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5099_RS18460	COG4137	Cytochrome C assembly protein
C5099_RS18465	COG4536	flavin adenine dinucleotide binding
C5099_RS18485	COG0497	DNA recombination
C5099_RS18490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5099_RS18500	COG2867	negative regulation of translational initiation
C5099_RS18515	COG0582	viral genome integration into host DNA
C5099_RS18585	COG0579	oxidoreductase
C5099_RS18590	COG1012	belongs to the aldehyde dehydrogenase family
C5099_RS18595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5099_RS18600	COG1113	amino acid transport
C5099_RS18605	COG1802	Transcriptional regulator
C5099_RS18610	COG1652	LysM domain
C5099_RS18615	COG0401	homolog of Blt101
C5099_RS18620	COG0640	Transcriptional regulator
C5099_RS18625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5099_RS18630	COG2916	Histone family protein nucleoid-structuring protein H-NS
C5099_RS18645	COG4575	ribosome binding
C5099_RS18655	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5099_RS18665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5099_RS18675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5099_RS18680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5099_RS18690	COG4175	Glycine betaine
C5099_RS18695	COG4176	ABC-type proline glycine betaine transport system permease component
C5099_RS18700	COG2113	Glycine betaine
C5099_RS18705	COG2814	Major facilitator Superfamily
C5099_RS18710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5099_RS18720	COG1846	Transcriptional regulator
C5099_RS18725	COG1566	PFAM secretion protein HlyD family protein
C5099_RS18730	COG2814	Major facilitator Superfamily
C5099_RS18755	COG1238	metal cluster binding
C5099_RS18760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5099_RS18790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C5099_RS18810	COG1546	Belongs to the CinA family
C5099_RS18815	COG2951	lytic endotransglycosylase activity
C5099_RS18820	COG0517	IMP dehydrogenase activity
C5099_RS18820	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5099_RS18840	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C5099_RS18845	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS18860	COG5499	transcription regulator containing HTH domain
C5099_RS18865	COG4680	protein conserved in bacteria
C5099_RS18875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C5099_RS18885	COG3260	NADH ubiquinone oxidoreductase 20
C5099_RS18890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5099_RS18895	COG3261	NADH dehydrogenase
C5099_RS18895	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C5099_RS18900	COG0650	Formate hydrogenlyase subunit 4
C5099_RS18905	COG0651	ATP synthesis coupled electron transport
C5099_RS18910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS18920	COG0375	protein maturation
C5099_RS18925	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C5099_RS18930	COG0298	carbon dioxide binding
C5099_RS18935	COG0409	Hydrogenase expression formation protein
C5099_RS18940	COG0309	Hydrogenase expression formation protein (HypE)
C5099_RS18945	COG3604	Transcriptional regulator
C5099_RS18960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5099_RS18965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5099_RS18970	COG1349	DNA-binding transcription factor activity
C5099_RS18975	COG2084	Dehydrogenase
C5099_RS18980	COG3395	kinase activity
C5099_RS18985	COG0235	Class ii aldolase
C5099_RS18995	COG2610	gluconate transmembrane transporter activity
C5099_RS19010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5099_RS19015	COG4942	peptidase
C5099_RS19015	COG1388	LysM domain
C5099_RS19070	COG2234	aminopeptidase activity
C5099_RS19110	COG0720	synthase
C5099_RS19115	COG0644	oxidoreductase
C5099_RS19120	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C5099_RS19125	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C5099_RS19130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5099_RS19135	COG2086	electron transfer activity
C5099_RS19140	COG0477	Major facilitator Superfamily
C5099_RS19145	COG0277	FAD linked oxidase domain protein
C5099_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS19155	COG2223	nitrite transmembrane transporter activity
C5099_RS19160	COG1070	Carbohydrate kinase
C5099_RS19190	COG0602	queuosine metabolic process
C5099_RS19200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5099_RS19210	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5099_RS19225	COG3956	TIGRFAM MazG family protein
C5099_RS19230	COG2337	Toxic component of a toxin-antitoxin (TA) module
C5099_RS19235	COG2336	PFAM SpoVT AbrB
C5099_RS19240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5099_RS19250	COG3850	Histidine kinase
C5099_RS19250	COG4999	Histidine kinase
C5099_RS19250	COG2205	protein histidine kinase activity
C5099_RS19250	COG3437	response regulator, receiver
C5099_RS19255	COG4948	Mandelate Racemase Muconate Lactonizing
C5099_RS19260	COG4948	Mandelate Racemase Muconate Lactonizing
C5099_RS19265	COG2271	Major facilitator Superfamily
C5099_RS19270	COG0716	FMN binding
C5099_RS19275	COG0564	pseudouridine synthase activity
C5099_RS19280	COG3098	single-species biofilm formation
C5099_RS19295	COG1611	Belongs to the LOG family
C5099_RS19300	COG0814	amino acid
C5099_RS19305	COG1760	l-serine dehydratase
C5099_RS19315	COG1454	alcohol dehydrogenase
C5099_RS19320	COG0235	Class ii aldolase
C5099_RS19325	COG0738	Major facilitator superfamily
C5099_RS19335	COG1070	Carbohydrate kinase
C5099_RS19345	COG1349	DNA-binding transcription factor activity
C5099_RS19355	COG2363	Small membrane protein
C5099_RS19360	COG0583	DNA-binding transcription factor activity
C5099_RS19370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5099_RS19375	COG2166	iron-sulfur cluster assembly
C5099_RS19380	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5099_RS19385	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C5099_RS19410	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5099_RS19415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5099_RS19415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5099_RS19420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5099_RS19430	COG1025	Belongs to the peptidase M16 family
C5099_RS19435	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C5099_RS19440	COG4967	type IV pilus modification protein PilV
C5099_RS19450	COG4795	General secretion pathway protein
C5099_RS19455	COG2165	general secretion pathway protein
C5099_RS19470	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C5099_RS19485	COG0861	Integral membrane protein TerC family
C5099_RS19495	COG0667	Aldo Keto reductase
C5099_RS19510	COG1609	Transcriptional regulator
C5099_RS19520	COG0583	DNA-binding transcription factor activity
C5099_RS19525	COG1794	racemase activity, acting on amino acids and derivatives
C5099_RS19530	COG2814	Major facilitator Superfamily
C5099_RS19535	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS19545	COG0183	Belongs to the thiolase family
C5099_RS19550	COG0814	amino acid
C5099_RS19575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C5099_RS19580	COG2080	2 iron, 2 sulfur cluster binding
C5099_RS19585	COG3829	transcription factor binding
C5099_RS19590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5099_RS19595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5099_RS19600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5099_RS19610	COG0549	Belongs to the carbamate kinase family
C5099_RS19615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5099_RS19615	COG3608	succinylglutamate desuccinylase aspartoacylase
C5099_RS19620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5099_RS19625	COG2068	MobA-Related Protein
C5099_RS19630	COG0493	'glutamate synthase
C5099_RS19630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS19635	COG0402	S-adenosylhomocysteine deaminase activity
C5099_RS19640	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C5099_RS19645	COG2080	2 iron, 2 sulfur cluster binding
C5099_RS19645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5099_RS19655	COG0402	S-adenosylhomocysteine deaminase activity
C5099_RS19660	COG2252	PERMEase
C5099_RS19670	COG0493	'glutamate synthase
C5099_RS19670	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS19680	COG2233	PERMEase
C5099_RS19695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5099_RS19705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5099_RS19710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5099_RS19715	COG4974	Belongs to the 'phage' integrase family
C5099_RS19720	COG0716	FMN binding
C5099_RS19730	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C5099_RS19740	COG1272	protein, Hemolysin III
C5099_RS19750	COG2723	6-phospho-beta-galactosidase activity
C5099_RS19770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5099_RS19775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5099_RS19780	COG0006	proline dipeptidase activity
C5099_RS19805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5099_RS19815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5099_RS19845	COG0583	DNA-binding transcription factor activity
C5099_RS19850	COG2968	Membrane
C5099_RS19855	COG1279	arginine transmembrane transporter activity
C5099_RS19860	COG0668	transmembrane transport
C5099_RS19865	COG0191	fructose-bisphosphate aldolase activity
C5099_RS19905	COG1122	ATPase activity
C5099_RS19910	COG1072	(Pantothenic acid kinase))
C5099_RS19925	COG1063	alcohol dehydrogenase
C5099_RS19930	COG2213	PTS system mannitol-specific
C5099_RS19935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS19940	COG0330	HflC and HflK could
C5099_RS19945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5099_RS19950	COG0501	Belongs to the peptidase M48B family
C5099_RS19965	COG1166	arginine decarboxylase activity
C5099_RS19990	COG2814	Major facilitator Superfamily
C5099_RS20000	COG2356	endonuclease I
C5099_RS20005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5099_RS20010	COG0189	ligase activity
C5099_RS20025	COG2805	Type II/IV secretion system protein
C5099_RS20030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5099_RS20035	COG0762	integral membrane protein
C5099_RS20045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5099_RS20050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5099_RS20060	COG0252	asparaginase activity
C5099_RS20070	COG3171	Protein conserved in bacteria
C5099_RS20085	COG1194	a g-specific adenine glycosylase
C5099_RS20100	COG2211	Major facilitator Superfamily
C5099_RS20105	COG1982	Orn Lys Arg decarboxylase major
C5099_RS20115	COG1811	Na channel or pump
C5099_RS20125	COG0582	viral genome integration into host DNA
C5099_RS20135	COG3423	Transcriptional regulator
C5099_RS20215	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C5099_RS20245	COG2165	general secretion pathway protein
C5099_RS20250	COG1459	type II secretion system
C5099_RS20255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5099_RS20265	COG3031	protein transport across the cell outer membrane
C5099_RS20275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C5099_RS20285	COG3064	Membrane
C5099_RS20305	COG1620	l-lactate permease
C5099_RS20310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5099_RS20315	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C5099_RS20320	COG0247	lactate metabolic process
C5099_RS20325	COG0277	FAD linked oxidase domain protein
C5099_RS20330	COG0277	FAD linked oxidase domain protein
C5099_RS20335	COG2186	Transcriptional regulator
C5099_RS20340	COG0456	acetyltransferase
C5099_RS20350	COG0318	PFAM AMP-dependent synthetase and ligase
C5099_RS20360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5099_RS20365	COG0156	8-amino-7-oxononanoate synthase activity
C5099_RS20380	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C5099_RS20390	COG2244	polysaccharide biosynthetic process
C5099_RS20395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5099_RS20400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5099_RS20405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5099_RS20410	COG0306	phosphate transporter
C5099_RS20415	COG0754	glutathionylspermidine amidase activity
C5099_RS20420	COG0625	glutathione transferase activity
C5099_RS20425	COG0298	carbon dioxide binding
C5099_RS20430	COG0375	protein maturation
C5099_RS20435	COG1773	rubredoxin
C5099_RS20440	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C5099_RS20445	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C5099_RS20450	COG5557	Pfam Polysulphide reductase, NrfD
C5099_RS20455	COG0437	4 iron, 4 sulfur cluster binding
C5099_RS20460	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C5099_RS20480	COG0667	Aldo Keto reductase
C5099_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
C5099_RS20495	COG0848	biopolymer transport protein
C5099_RS20500	COG0811	peptide transport
C5099_RS20510	COG0626	cystathionine gamma-synthase activity
C5099_RS20515	COG0586	Pfam SNARE associated Golgi protein
C5099_RS20520	COG2207	Transcriptional regulator
C5099_RS20525	COG1979	alcohol dehydrogenase
C5099_RS20530	COG0656	L-ascorbic acid biosynthetic process
C5099_RS20540	COG4238	major outer membrane lipoprotein
C5099_RS20545	COG1032	radical SAM domain protein
C5099_RS20550	COG2186	Transcriptional regulator
C5099_RS20555	COG0246	Mannitol dehydrogenase
C5099_RS20560	COG1063	alcohol dehydrogenase
C5099_RS20565	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C5099_RS20585	COG2132	Multicopper oxidase
C5099_RS20590	COG0204	Acyl-transferase
C5099_RS20595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5099_RS20600	COG4166	transmembrane transport
C5099_RS20605	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C5099_RS20610	COG3111	PFAM Bacterial OB fold (BOF) protein
C5099_RS20615	COG0745	RESPONSE REGULATOR receiver
C5099_RS20620	COG0642	Histidine kinase
C5099_RS20625	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5099_RS20630	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5099_RS20635	COG1737	Transcriptional regulator
C5099_RS20645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5099_RS20655	COG1120	ATPase activity
C5099_RS20660	COG4774	siderophore transport
C5099_RS20665	COG0187	DNA topoisomerase II activity
C5099_RS20675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5099_RS20680	COG3151	Protein conserved in bacteria
C5099_RS20690	COG1538	Outer membrane efflux protein
C5099_RS20705	COG0754	glutathionylspermidine amidase activity
C5099_RS20715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C5099_RS20725	COG3384	dioxygenase
C5099_RS20740	COG3539	Fimbrial protein
C5099_RS20745	COG3188	usher protein
C5099_RS20750	COG3121	Chaperone
C5099_RS20755	COG3539	Fimbrial protein
C5099_RS20780	COG1585	Membrane protein implicated in regulation of membrane protease activity
C5099_RS20785	COG2268	Band 7 protein
C5099_RS20810	COG3025	triphosphatase activity
C5099_RS20820	COG4991	sh3 domain protein
C5099_RS20835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5099_RS20860	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5099_RS20880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5099_RS20885	COG0358	DNA primase activity
C5099_RS20895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5099_RS20910	COG2375	cellular response to nickel ion
C5099_RS20920	COG1695	Transcriptional regulator
C5099_RS20925	COG0840	transmembrane signaling receptor activity
C5099_RS20940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5099_RS20945	COG1609	Transcriptional regulator
C5099_RS20950	COG3250	beta-galactosidase activity
C5099_RS20955	COG2731	YhcH YjgK YiaL family protein
C5099_RS20960	COG0531	amino acid
C5099_RS20970	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C5099_RS20970	COG3408	Glycogen debranching enzyme
C5099_RS20975	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5099_RS20975	COG1902	pentaerythritol trinitrate reductase activity
C5099_RS20980	COG5499	transcription regulator containing HTH domain
C5099_RS20985	COG4680	protein conserved in bacteria
C5099_RS20995	COG1451	nucleotide metabolic process
C5099_RS21000	COG2949	membrane
C5099_RS21005	COG0673	inositol 2-dehydrogenase activity
C5099_RS21010	COG0861	Integral membrane protein TerC family
C5099_RS21025	COG2721	sulfolactate sulfo-lyase activity
C5099_RS21035	COG2271	Major facilitator Superfamily
C5099_RS21040	COG2186	Transcriptional regulator
C5099_RS21045	COG0586	Pfam SNARE associated Golgi protein
C5099_RS21055	COG1422	Protein of unknown function (DUF1090)
C5099_RS21060	COG4575	ribosome binding
C5099_RS21065	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C5099_RS21075	COG2259	Doxx family
C5099_RS21080	COG0435	Glutathione S-transferase
C5099_RS21085	COG3152	Membrane
C5099_RS21090	COG0583	DNA-binding transcription factor activity
C5099_RS21095	COG1741	Belongs to the pirin family
C5099_RS21110	COG0814	amino acid
C5099_RS21120	COG1760	l-serine dehydratase
C5099_RS21125	COG0251	oxidation-reduction process
C5099_RS21130	COG1882	Formate acetyltransferase
C5099_RS21135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5099_RS21145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5099_RS21155	COG0583	DNA-binding transcription factor activity
C5099_RS21170	COG1929	Belongs to the glycerate kinase type-1 family
C5099_RS21175	COG2084	Dehydrogenase
C5099_RS21185	COG2271	Major facilitator Superfamily
C5099_RS21190	COG2721	sulfolactate sulfo-lyase activity
C5099_RS21210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS21220	COG3716	PTS system mannose fructose sorbose family IID component
C5099_RS21225	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS21230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5099_RS21235	COG2222	sugar isomerase
C5099_RS21245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS21250	COG3715	PTS system
C5099_RS21255	COG3716	PTS system mannose fructose sorbose family IID component
C5099_RS21260	COG0363	glucosamine-6-phosphate deaminase activity
C5099_RS21265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5099_RS21285	COG2823	Periplasmic or secreted lipoprotein
C5099_RS21290	COG0701	Predicted permease
C5099_RS21295	COG0702	epimerase
C5099_RS21300	COG0693	protein deglycase activity
C5099_RS21315	COG3153	acetyltransferase
C5099_RS21320	COG3154	lipid carrier protein
C5099_RS21325	COG0826	peptidase U32
C5099_RS21330	COG0826	peptidase U32
C5099_RS21335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5099_RS21340	COG0814	amino acid
C5099_RS21345	COG0513	Belongs to the DEAD box helicase family
C5099_RS21385	COG0195	Participates in both transcription termination and antitermination
C5099_RS21405	COG2194	sulfuric ester hydrolase activity
C5099_RS21420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5099_RS21430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5099_RS21435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5099_RS21445	COG1534	Rna-binding protein
C5099_RS21450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5099_RS21455	COG2027	D-alanyl-D-alanine carboxypeptidase
C5099_RS21465	COG0697	spore germination
C5099_RS21480	COG0142	geranyltranstransferase activity
C5099_RS21485	COG3423	Transcriptional regulator
C5099_RS21495	COG5007	Belongs to the BolA IbaG family
C5099_RS21500	COG3113	response to antibiotic
C5099_RS21505	COG2854	intermembrane phospholipid transfer
C5099_RS21510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5099_RS21515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5099_RS21520	COG1127	ABC transporter
C5099_RS21525	COG0530	calcium, potassium:sodium antiporter activity
C5099_RS21530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5099_RS21530	COG0517	IMP dehydrogenase activity
C5099_RS21535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C5099_RS21540	COG3117	lipopolysaccharide transmembrane transporter activity
C5099_RS21545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C5099_RS21550	COG1137	ATPase activity
C5099_RS21555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5099_RS21560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5099_RS21575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS21580	COG0515	serine threonine protein kinase
C5099_RS21590	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C5099_RS21595	COG0784	Response regulator, receiver
C5099_RS21595	COG2198	Histidine kinase
C5099_RS21595	COG5002	protein histidine kinase activity
C5099_RS21600	COG1242	4 iron, 4 sulfur cluster binding
C5099_RS21620	COG0493	'glutamate synthase
C5099_RS21625	COG2731	YhcH YjgK YiaL family protein
C5099_RS21630	COG1940	carbohydrate kinase activity
C5099_RS21640	COG2814	Major facilitator Superfamily
C5099_RS21655	COG2969	positive regulation of protein catabolic process
C5099_RS21660	COG0625	glutathione transferase activity
C5099_RS21680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5099_RS21685	COG3105	Protein conserved in bacteria
C5099_RS21690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5099_RS21695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5099_RS21715	COG2732	(Barnase) inhibitor
C5099_RS21735	COG0583	DNA-binding transcription factor activity
C5099_RS21740	COG0312	modulator of DNA gyrase
C5099_RS21745	COG3164	Protein of unknown function
C5099_RS21750	COG1530	ribonuclease E activity
C5099_RS21760	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C5099_RS21765	COG1792	Involved in formation and maintenance of cell shape
C5099_RS21770	COG1077	Cell shape determining protein MreB Mrl
C5099_RS21785	COG2199	diguanylate cyclase activity
C5099_RS21785	COG2200	EAL domain
C5099_RS21790	COG0604	alcohol dehydrogenase
C5099_RS21805	COG0511	ligase activity, forming carbon-carbon bonds
C5099_RS21810	COG0439	Biotin carboxylase
C5099_RS21820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS21825	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5099_RS21845	COG1349	DNA-binding transcription factor activity
C5099_RS21850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS21855	COG3924	membrane
C5099_RS21860	COG4145	pantothenate transmembrane transporter activity
C5099_RS21870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5099_RS21880	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C5099_RS21890	COG1309	transcriptional regulator
C5099_RS21900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5099_RS21905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5099_RS21920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5099_RS21925	COG4597	amino acid ABC transporter
C5099_RS21930	COG0765	amino acid transport
C5099_RS21935	COG1126	abc transporter atp-binding protein
C5099_RS21970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5099_RS21990	COG0551	DNA topoisomerase type I activity
C5099_RS22000	COG0758	DNA mediated transformation
C5099_RS22020	COG0569	domain protein
C5099_RS22030	COG3036	rescue of stalled ribosome
C5099_RS22040	COG0789	Transcriptional regulator
C5099_RS22080	COG0201	protein transport
C5099_RS22170	COG0089	rRNA binding
C5099_RS22250	COG2964	Protein conserved in bacteria
C5099_RS22255	COG0545	Peptidyl-prolyl cis-trans isomerase
C5099_RS22265	COG1047	Peptidyl-prolyl cis-trans
C5099_RS22270	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C5099_RS22290	COG0488	(ABC) transporter
C5099_RS22305	COG3954	Phosphoribulokinase
C5099_RS22310	COG1765	OsmC-like protein
C5099_RS22320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5099_RS22325	COG1289	transmembrane transporter activity
C5099_RS22330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5099_RS22335	COG0512	Glutamine amidotransferase of anthranilate synthase
C5099_RS22340	COG2184	nucleotidyltransferase activity
C5099_RS22350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5099_RS22360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5099_RS22365	COG2146	nitrite reductase [NAD(P)H] activity
C5099_RS22370	COG2116	formate transmembrane transporter activity
C5099_RS22385	COG0626	cystathionine gamma-synthase activity
C5099_RS22400	COG1735	metal-dependent hydrolase with the TIM-barrel fold
C5099_RS22405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C5099_RS22410	COG3457	Alanine racemase
C5099_RS22420	COG2188	Transcriptional regulator
C5099_RS22425	COG0180	Tryptophanyl-tRNA synthetase
C5099_RS22430	COG0546	phosphoglycolate phosphatase activity
C5099_RS22435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5099_RS22440	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C5099_RS22445	COG3266	domain, Protein
C5099_RS22460	COG4796	Type ii and iii secretion system protein
C5099_RS22475	COG3166	PFAM Fimbrial assembly family protein
C5099_RS22480	COG4972	Pilus assembly protein
C5099_RS22485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C5099_RS22490	COG0494	nUDIX hydrolase
C5099_RS22500	COG1011	Hydrolase
C5099_RS22505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5099_RS22515	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C5099_RS22555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5099_RS22560	COG2183	response to ionizing radiation
C5099_RS22570	COG1918	ferrous iron import across plasma membrane
C5099_RS22575	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C5099_RS22610	COG2610	gluconate transmembrane transporter activity
C5099_RS22615	COG1640	4-alpha-glucanotransferase
C5099_RS22620	COG0058	SHG alpha-glucan phosphorylase activity
C5099_RS22645	COG1690	Belongs to the RtcB family
C5099_RS22655	COG1349	DNA-binding transcription factor activity
C5099_RS22670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5099_RS22710	COG3188	usher protein
C5099_RS22715	COG3121	Chaperone
C5099_RS22725	COG0058	SHG alpha-glucan phosphorylase activity
C5099_RS22750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5099_RS22755	COG2095	MarC family integral membrane protein
C5099_RS22760	COG2610	gluconate transmembrane transporter activity
C5099_RS22765	COG3265	gluconokinase activity
C5099_RS22770	COG1609	Transcriptional regulator
C5099_RS22775	COG1741	Belongs to the pirin family
C5099_RS22780	COG0673	inositol 2-dehydrogenase activity
C5099_RS22790	COG1247	-acetyltransferase
C5099_RS22795	COG0405	Gamma-glutamyltransferase
C5099_RS22805	COG0584	glycerophosphoryl diester phosphodiesterase
C5099_RS22840	COG0410	ABC transporter
C5099_RS22845	COG0411	ABC transporter
C5099_RS22850	COG4177	L-phenylalanine transmembrane transporter activity
C5099_RS22855	COG0559	Belongs to the binding-protein-dependent transport system permease family
C5099_RS22860	COG0683	leucine binding
C5099_RS22865	COG0456	acetyltransferase
C5099_RS22870	COG0683	leucine binding
C5099_RS22875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5099_RS22880	COG2177	Part of the ABC transporter FtsEX involved in
C5099_RS22885	COG2884	Cell division ATP-binding protein ftsE
C5099_RS22890	COG0552	protein localization to endoplasmic reticulum
C5099_RS22895	COG0742	ribosomal rna small subunit methyltransferase
C5099_RS22900	COG3776	membrane
C5099_RS22910	COG3714	YhhN family
C5099_RS22925	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C5099_RS22935	COG0477	Major facilitator Superfamily
C5099_RS22940	COG0628	permease
C5099_RS22945	COG2091	lysine biosynthetic process via aminoadipic acid
C5099_RS22950	COG0747	negative chemotaxis
C5099_RS22955	COG0601	transmembrane transport
C5099_RS22960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5099_RS22965	COG0444	Belongs to the ABC transporter superfamily
C5099_RS22980	COG2188	Transcriptional regulator
C5099_RS22990	COG3414	Phosphotransferase system galactitol-specific IIB component
C5099_RS22995	COG3775	system Galactitol-specific IIC component
C5099_RS23010	COG0191	fructose-bisphosphate aldolase activity
C5099_RS23015	COG0842	Transport permease protein
C5099_RS23020	COG0842	Transport permease protein
C5099_RS23020	COG1129	ABC transporter
C5099_RS23025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5099_RS23040	COG2081	HI0933 family
C5099_RS23045	COG0306	phosphate transporter
C5099_RS23055	COG0589	response to stress
C5099_RS23070	COG3104	oligopeptide transport
C5099_RS23080	COG0339	signal peptide processing
C5099_RS23085	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C5099_RS23090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5099_RS23110	COG1393	Belongs to the ArsC family
C5099_RS23120	COG3065	identical protein binding
C5099_RS23130	COG2197	response regulator
C5099_RS23135	COG3720	iron ion transport
C5099_RS23140	COG4771	TonB-dependent receptor
C5099_RS23165	COG3721	Heme iron utilization protein
C5099_RS23175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5099_RS23185	COG1285	pathogenesis
C5099_RS23200	COG3247	response to pH
C5099_RS23205	COG2771	luxR family
C5099_RS23215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5099_RS23220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5099_RS23230	COG2207	Transcriptional regulator
C5099_RS23235	COG2207	Transcriptional regulator
C5099_RS23240	COG0076	glutamate decarboxylase activity
C5099_RS23245	COG1858	cytochrome C peroxidase
C5099_RS23255	COG2197	response regulator
C5099_RS23260	COG0583	DNA-binding transcription factor activity
C5099_RS23265	COG1295	ribonuclease BN
C5099_RS23270	COG0477	Major facilitator Superfamily
C5099_RS23280	COG2200	EAL domain
C5099_RS23290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5099_RS23295	COG0612	Peptidase, M16
C5099_RS23315	COG2199	diguanylate cyclase activity
C5099_RS23315	COG2200	EAL domain
C5099_RS23320	COG0457	Tetratricopeptide repeat
C5099_RS23320	COG3118	belongs to the thioredoxin family
C5099_RS23325	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C5099_RS23330	COG1215	transferase activity, transferring glycosyl groups
C5099_RS23360	COG2194	sulfuric ester hydrolase activity
C5099_RS23395	COG0814	amino acid
C5099_RS23400	COG3550	peptidyl-serine autophosphorylation
C5099_RS23405	COG3550	peptidyl-serine autophosphorylation
C5099_RS23415	COG4608	Belongs to the ABC transporter superfamily
C5099_RS23420	COG0444	Belongs to the ABC transporter superfamily
C5099_RS23425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5099_RS23430	COG0601	transmembrane transport
C5099_RS23440	COG0747	negative chemotaxis
C5099_RS23450	COG2194	sulfuric ester hydrolase activity
C5099_RS23455	COG2223	nitrite transmembrane transporter activity
C5099_RS23465	COG5571	outer membrane autotransporter
C5099_RS23470	COG2818	Glycosylase
C5099_RS23475	COG0456	acetyltransferase
C5099_RS23480	COG0243	molybdopterin cofactor binding
C5099_RS23485	COG2885	chlorophyll binding
C5099_RS23500	COG2944	sequence-specific DNA binding
C5099_RS23505	COG1278	Cold shock
C5099_RS23535	COG4682	membrane
C5099_RS23540	COG4682	membrane
C5099_RS23545	COG4682	membrane
C5099_RS23550	COG1070	Carbohydrate kinase
C5099_RS23560	COG4213	ABC transporter substrate-binding protein
C5099_RS23570	COG4214	carbohydrate transport
C5099_RS23575	COG2207	Transcriptional regulator
C5099_RS23575	COG1609	Transcriptional regulator
C5099_RS23580	COG2992	FlgJ-related protein
C5099_RS23585	COG0366	Alpha amylase catalytic
C5099_RS23590	COG3977	Valine--pyruvate aminotransferase
C5099_RS23595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5099_RS23600	COG1414	Transcriptional regulator
C5099_RS23610	COG2731	YhcH YjgK YiaL family protein
C5099_RS23620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C5099_RS23630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5099_RS23635	COG1070	Carbohydrate kinase
C5099_RS23640	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C5099_RS23645	COG3623	hexulose-6-phosphate isomerase
C5099_RS23650	COG0235	Class ii aldolase
C5099_RS23655	COG1012	belongs to the aldehyde dehydrogenase family
C5099_RS23665	COG1454	alcohol dehydrogenase
C5099_RS23670	COG3276	selenocysteine insertion sequence binding
C5099_RS23680	COG0625	glutathione transferase activity
C5099_RS23685	COG1566	PFAM secretion protein HlyD family protein
C5099_RS23695	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS23695	COG2213	PTS system mannitol-specific
C5099_RS23705	COG3722	fumarate hydratase activity
C5099_RS23725	COG5295	Hep Hag repeat protein
C5099_RS23730	COG5295	Hep Hag repeat protein
C5099_RS23740	COG1620	l-lactate permease
C5099_RS23745	COG2186	Transcriptional regulator
C5099_RS23755	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5099_RS23760	COG1045	serine acetyltransferase
C5099_RS23775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5099_RS23780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5099_RS23795	COG4942	peptidase
C5099_RS23800	COG2861	carbohydrate metabolic process
C5099_RS23805	COG1216	Glycosyl transferase, family 2
C5099_RS23815	COG0156	8-amino-7-oxononanoate synthase activity
C5099_RS23825	COG0859	PFAM glycosyl transferase family 9
C5099_RS23830	COG0859	PFAM glycosyl transferase family 9
C5099_RS23835	COG3307	-O-antigen
C5099_RS23850	COG1216	Glycosyl transferase, family 2
C5099_RS23855	COG1442	glycosyl transferase family 8
C5099_RS23860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5099_RS23875	COG0515	serine threonine protein kinase
C5099_RS23880	COG0438	transferase activity, transferring glycosyl groups
C5099_RS23885	COG0859	PFAM glycosyl transferase family 9
C5099_RS23890	COG1519	Transferase
C5099_RS23920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5099_RS23950	COG1561	YicC-like family, N-terminal region
C5099_RS23955	COG2860	membrane
C5099_RS23960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5099_RS23965	COG0194	GDP metabolic process
C5099_RS23975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5099_RS23980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5099_RS23985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5099_RS23990	COG0786	glutamate:sodium symporter activity
C5099_RS23995	COG2233	PERMEase
C5099_RS24000	COG2982	Protein involved in outer membrane biogenesis
C5099_RS24010	COG1940	carbohydrate kinase activity
C5099_RS24025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS24025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS24030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS24035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS24035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5099_RS24035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5099_RS24040	COG3711	transcriptional antiterminator
C5099_RS24045	COG1501	Belongs to the glycosyl hydrolase 31 family
C5099_RS24050	COG2211	Major facilitator Superfamily
C5099_RS24285	COG0697	spore germination
C5099_RS24290	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C5099_RS24340	COG2252	PERMEase
C5099_RS24350	COG2271	Major facilitator Superfamily
C5099_RS24355	COG2271	Major facilitator Superfamily
C5099_RS24360	COG3851	Histidine kinase
C5099_RS24365	COG2197	response regulator
C5099_RS24370	COG0440	acetolactate synthase activity
C5099_RS24375	COG0028	Belongs to the TPP enzyme family
C5099_RS24390	COG2814	Major facilitator Superfamily
C5099_RS24395	COG0641	radical SAM
C5099_RS24405	COG2149	membrane
C5099_RS24410	COG3119	arylsulfatase activity
C5099_RS24415	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5099_RS24420	COG2207	Transcriptional regulator
C5099_RS24440	COG5645	(Lipo)protein
C5099_RS24445	COG0823	Involved in the tonB-independent uptake of proteins
C5099_RS24455	COG2271	Major facilitator Superfamily
C5099_RS24465	COG0800	Aldolase
C5099_RS24470	COG3734	2-keto-3-deoxy-galactonokinase
C5099_RS24475	COG2186	Transcriptional regulator
C5099_RS24485	COG0561	phosphatase activity
C5099_RS24490	COG3753	Protein conserved in bacteria
C5099_RS24495	COG0187	DNA topoisomerase II activity
C5099_RS24505	COG0592	DNA-directed DNA polymerase activity
C5099_RS24555	COG0814	amino acid
C5099_RS24565	COG0583	DNA-binding transcription factor activity
C5099_RS24570	COG2091	lysine biosynthetic process via aminoadipic acid
C5099_RS24575	COG0431	NADPH-dependent FMN reductase
C5099_RS24580	COG2252	PERMEase
C5099_RS24585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5099_RS24595	COG0363	glucosamine-6-phosphate deaminase activity
C5099_RS24600	COG2382	esterase
C5099_RS24610	COG2723	6-phospho-beta-galactosidase activity
C5099_RS24615	COG2190	(PTS) system
C5099_RS24615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5099_RS24615	COG1263	PTS System
C5099_RS24620	COG3711	transcriptional antiterminator
C5099_RS24625	COG0704	Plays a role in the regulation of phosphate uptake
C5099_RS24630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5099_RS24635	COG0581	inorganic phosphate transmembrane transporter activity
C5099_RS24640	COG0573	inorganic phosphate transmembrane transporter activity
C5099_RS24645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5099_RS24655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5099_RS24705	COG3312	ion transport