locus-tag	class	description
RG65_RS00020	COG1126	abc transporter atp-binding protein
RG65_RS00025	COG0765	amino acid transport
RG65_RS00030	COG4597	amino acid ABC transporter
RG65_RS00035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS00045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG65_RS00050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG65_RS00060	COG1309	transcriptional regulator
RG65_RS00070	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RG65_RS00080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG65_RS00090	COG4145	pantothenate transmembrane transporter activity
RG65_RS00095	COG3924	membrane
RG65_RS00100	COG0439	Biotin carboxylase
RG65_RS00105	COG0511	ligase activity, forming carbon-carbon bonds
RG65_RS00120	COG0604	alcohol dehydrogenase
RG65_RS00125	COG2200	EAL domain
RG65_RS00125	COG2199	diguanylate cyclase activity
RG65_RS00140	COG1077	Cell shape determining protein MreB Mrl
RG65_RS00145	COG1792	Involved in formation and maintenance of cell shape
RG65_RS00150	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RG65_RS00160	COG1530	ribonuclease E activity
RG65_RS00165	COG3164	Protein of unknown function
RG65_RS00170	COG0312	modulator of DNA gyrase
RG65_RS00175	COG0583	DNA-binding transcription factor activity
RG65_RS00195	COG2732	(Barnase) inhibitor
RG65_RS00215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG65_RS00220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG65_RS00225	COG3105	Protein conserved in bacteria
RG65_RS00230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RG65_RS00245	COG0625	glutathione transferase activity
RG65_RS00250	COG2969	positive regulation of protein catabolic process
RG65_RS00255	COG3069	C4-dicarboxylate transmembrane transporter activity
RG65_RS00290	COG2731	YhcH YjgK YiaL family protein
RG65_RS00295	COG4804	nuclease activity
RG65_RS00300	COG0493	'glutamate synthase
RG65_RS00305	COG0070	glutamate synthase
RG65_RS00305	COG0069	glutamate synthase activity
RG65_RS00305	COG0067	glutamate synthase
RG65_RS00315	COG1242	4 iron, 4 sulfur cluster binding
RG65_RS00320	COG2198	Histidine kinase
RG65_RS00320	COG0784	Response regulator, receiver
RG65_RS00320	COG5002	protein histidine kinase activity
RG65_RS00325	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RG65_RS00335	COG0515	serine threonine protein kinase
RG65_RS00340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS00355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG65_RS00360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RG65_RS00365	COG1137	ATPase activity
RG65_RS00370	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RG65_RS00375	COG3117	lipopolysaccharide transmembrane transporter activity
RG65_RS00380	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RG65_RS00385	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG65_RS00385	COG0517	IMP dehydrogenase activity
RG65_RS00390	COG0530	calcium, potassium:sodium antiporter activity
RG65_RS00395	COG1127	ABC transporter
RG65_RS00400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RG65_RS00405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG65_RS00410	COG2854	intermembrane phospholipid transfer
RG65_RS00415	COG3113	response to antibiotic
RG65_RS00420	COG5007	Belongs to the BolA IbaG family
RG65_RS00430	COG3423	Transcriptional regulator
RG65_RS00435	COG0142	geranyltranstransferase activity
RG65_RS00450	COG0697	spore germination
RG65_RS00460	COG2027	D-alanyl-D-alanine carboxypeptidase
RG65_RS00465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG65_RS00470	COG1534	Rna-binding protein
RG65_RS00480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RG65_RS00485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RG65_RS00495	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG65_RS00510	COG2194	sulfuric ester hydrolase activity
RG65_RS00530	COG0195	Participates in both transcription termination and antitermination
RG65_RS00570	COG0513	Belongs to the DEAD box helicase family
RG65_RS00580	COG0814	amino acid
RG65_RS00585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RG65_RS00590	COG0826	peptidase U32
RG65_RS00595	COG0826	peptidase U32
RG65_RS00600	COG3154	lipid carrier protein
RG65_RS00605	COG3153	acetyltransferase
RG65_RS00620	COG0693	protein deglycase activity
RG65_RS00625	COG0702	epimerase
RG65_RS00630	COG0701	Predicted permease
RG65_RS00635	COG2823	Periplasmic or secreted lipoprotein
RG65_RS00655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RG65_RS00660	COG3539	Fimbrial protein
RG65_RS00665	COG3188	usher protein
RG65_RS00680	COG3188	usher protein
RG65_RS00685	COG3121	Chaperone
RG65_RS00690	COG3539	Fimbrial protein
RG65_RS00695	COG0363	glucosamine-6-phosphate deaminase activity
RG65_RS00700	COG3716	PTS system mannose fructose sorbose family IID component
RG65_RS00705	COG3715	PTS system
RG65_RS00710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS00720	COG2222	sugar isomerase
RG65_RS00725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG65_RS00730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS00735	COG3716	PTS system mannose fructose sorbose family IID component
RG65_RS00745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS00760	COG1349	DNA-binding transcription factor activity
RG65_RS00770	COG2002	toxin-antitoxin pair type II binding
RG65_RS00775	COG2721	sulfolactate sulfo-lyase activity
RG65_RS00780	COG2271	Major facilitator Superfamily
RG65_RS00790	COG2084	Dehydrogenase
RG65_RS00795	COG1929	Belongs to the glycerate kinase type-1 family
RG65_RS00830	COG0583	DNA-binding transcription factor activity
RG65_RS00835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG65_RS00845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG65_RS00850	COG1882	Formate acetyltransferase
RG65_RS00855	COG0251	oxidation-reduction process
RG65_RS00860	COG1760	l-serine dehydratase
RG65_RS00865	COG0814	amino acid
RG65_RS00880	COG1741	Belongs to the pirin family
RG65_RS00885	COG0583	DNA-binding transcription factor activity
RG65_RS00895	COG3152	Membrane
RG65_RS00900	COG3152	Membrane
RG65_RS00905	COG0435	Glutathione S-transferase
RG65_RS00910	COG2259	Doxx family
RG65_RS00920	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
RG65_RS00925	COG4575	ribosome binding
RG65_RS00930	COG1422	Protein of unknown function (DUF1090)
RG65_RS00940	COG0586	Pfam SNARE associated Golgi protein
RG65_RS00945	COG2186	Transcriptional regulator
RG65_RS00985	COG2271	Major facilitator Superfamily
RG65_RS00995	COG2721	sulfolactate sulfo-lyase activity
RG65_RS01005	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RG65_RS01010	COG0861	Integral membrane protein TerC family
RG65_RS01015	COG0673	inositol 2-dehydrogenase activity
RG65_RS01020	COG2949	membrane
RG65_RS01025	COG1451	nucleotide metabolic process
RG65_RS01035	COG4680	protein conserved in bacteria
RG65_RS01040	COG5499	transcription regulator containing HTH domain
RG65_RS01045	COG1902	pentaerythritol trinitrate reductase activity
RG65_RS01045	COG0446	pyridine nucleotide-disulphide oxidoreductase
RG65_RS01050	COG3408	Glycogen debranching enzyme
RG65_RS01050	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RG65_RS01060	COG0531	amino acid
RG65_RS01065	COG2731	YhcH YjgK YiaL family protein
RG65_RS01070	COG3250	beta-galactosidase activity
RG65_RS01075	COG1609	Transcriptional regulator
RG65_RS01085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RG65_RS01100	COG0840	transmembrane signaling receptor activity
RG65_RS01105	COG1695	Transcriptional regulator
RG65_RS01110	COG2375	cellular response to nickel ion
RG65_RS01125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG65_RS01135	COG0358	DNA primase activity
RG65_RS01140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RG65_RS01160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG65_RS01165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG65_RS01175	COG0583	DNA-binding transcription factor activity
RG65_RS01185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG65_RS01200	COG4991	sh3 domain protein
RG65_RS01210	COG3025	triphosphatase activity
RG65_RS01235	COG2268	Band 7 protein
RG65_RS01240	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG65_RS01250	COG3539	Fimbrial protein
RG65_RS01260	COG3188	usher protein
RG65_RS01265	COG3539	Fimbrial protein
RG65_RS01270	COG2960	long-chain fatty acid transporting porin activity
RG65_RS01290	COG3384	dioxygenase
RG65_RS01295	COG0754	glutathionylspermidine amidase activity
RG65_RS01310	COG1538	Outer membrane efflux protein
RG65_RS01315	COG0494	nUDIX hydrolase
RG65_RS01320	COG3151	Protein conserved in bacteria
RG65_RS01325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RG65_RS01330	COG3150	esterase
RG65_RS01335	COG0187	DNA topoisomerase II activity
RG65_RS01340	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RG65_RS01345	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG65_RS01355	COG0642	Histidine kinase
RG65_RS01360	COG0745	RESPONSE REGULATOR receiver
RG65_RS01365	COG3111	PFAM Bacterial OB fold (BOF) protein
RG65_RS01370	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG65_RS01380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG65_RS01390	COG0204	Acyl-transferase
RG65_RS01395	COG2132	Multicopper oxidase
RG65_RS01400	COG1032	radical SAM domain protein
RG65_RS01405	COG4238	major outer membrane lipoprotein
RG65_RS01415	COG0656	L-ascorbic acid biosynthetic process
RG65_RS01420	COG1979	alcohol dehydrogenase
RG65_RS01430	COG2207	Transcriptional regulator
RG65_RS01435	COG0586	Pfam SNARE associated Golgi protein
RG65_RS01440	COG0626	cystathionine gamma-synthase activity
RG65_RS01450	COG0811	peptide transport
RG65_RS01455	COG0848	biopolymer transport protein
RG65_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS01475	COG0667	Aldo Keto reductase
RG65_RS01495	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG65_RS01500	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS01505	COG5557	Pfam Polysulphide reductase, NrfD
RG65_RS01510	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG65_RS01515	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG65_RS01520	COG1773	rubredoxin
RG65_RS01525	COG0375	protein maturation
RG65_RS01530	COG0298	carbon dioxide binding
RG65_RS01545	COG0625	glutathione transferase activity
RG65_RS01550	COG0754	glutathionylspermidine amidase activity
RG65_RS01555	COG0306	phosphate transporter
RG65_RS01560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG65_RS01565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG65_RS01570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RG65_RS01575	COG2244	polysaccharide biosynthetic process
RG65_RS01585	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG65_RS01590	COG0795	lipopolysaccharide-transporting ATPase activity
RG65_RS01600	COG0156	8-amino-7-oxononanoate synthase activity
RG65_RS01605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RG65_RS01615	COG0318	PFAM AMP-dependent synthetase and ligase
RG65_RS01625	COG0456	acetyltransferase
RG65_RS01630	COG2186	Transcriptional regulator
RG65_RS01635	COG0277	FAD linked oxidase domain protein
RG65_RS01640	COG0277	FAD linked oxidase domain protein
RG65_RS01645	COG0247	lactate metabolic process
RG65_RS01650	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RG65_RS01655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG65_RS01660	COG1620	l-lactate permease
RG65_RS01680	COG3064	Membrane
RG65_RS01685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG65_RS01695	COG2165	general secretion pathway protein
RG65_RS01720	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RG65_RS01730	COG1811	Na channel or pump
RG65_RS01740	COG1982	Orn Lys Arg decarboxylase major
RG65_RS01745	COG2211	Major facilitator Superfamily
RG65_RS01760	COG1194	a g-specific adenine glycosylase
RG65_RS01775	COG3171	Protein conserved in bacteria
RG65_RS01785	COG0252	asparaginase activity
RG65_RS01795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG65_RS01810	COG0762	integral membrane protein
RG65_RS01815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RG65_RS01820	COG2805	Type II/IV secretion system protein
RG65_RS01835	COG0189	ligase activity
RG65_RS01840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RG65_RS01845	COG2356	endonuclease I
RG65_RS01855	COG2814	Major facilitator Superfamily
RG65_RS01885	COG1166	arginine decarboxylase activity
RG65_RS01900	COG0501	Belongs to the peptidase M48B family
RG65_RS01905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG65_RS01910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS01915	COG2213	PTS system mannitol-specific
RG65_RS01920	COG1063	alcohol dehydrogenase
RG65_RS01925	COG1494	fructose-1,6-bisphosphatase
RG65_RS01935	COG1072	(Pantothenic acid kinase))
RG65_RS01940	COG1122	ATPase activity
RG65_RS01945	COG1122	ATPase activity
RG65_RS01980	COG0191	fructose-bisphosphate aldolase activity
RG65_RS01985	COG0668	transmembrane transport
RG65_RS01990	COG1279	arginine transmembrane transporter activity
RG65_RS01995	COG2968	Membrane
RG65_RS02000	COG0583	DNA-binding transcription factor activity
RG65_RS02005	COG0427	acetyl-CoA hydrolase
RG65_RS02010	COG1024	Enoyl-CoA hydratase
RG65_RS02015	COG1703	isobutyryl-CoA mutase activity
RG65_RS02020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG65_RS02020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RG65_RS02045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RG65_RS02065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RG65_RS02090	COG0006	proline dipeptidase activity
RG65_RS02095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG65_RS02100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG65_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS02125	COG2723	6-phospho-beta-galactosidase activity
RG65_RS02135	COG1272	protein, Hemolysin III
RG65_RS02145	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RG65_RS02155	COG0716	FMN binding
RG65_RS02160	COG4974	Belongs to the 'phage' integrase family
RG65_RS02165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG65_RS02170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RG65_RS02195	COG2233	PERMEase
RG65_RS02205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS02205	COG0493	'glutamate synthase
RG65_RS02210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS02215	COG2252	PERMEase
RG65_RS02220	COG0402	S-adenosylhomocysteine deaminase activity
RG65_RS02225	COG2233	PERMEase
RG65_RS02230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG65_RS02230	COG2080	2 iron, 2 sulfur cluster binding
RG65_RS02235	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG65_RS02240	COG0402	S-adenosylhomocysteine deaminase activity
RG65_RS02245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS02245	COG0493	'glutamate synthase
RG65_RS02250	COG2068	MobA-Related Protein
RG65_RS02255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG65_RS02260	COG3608	succinylglutamate desuccinylase aspartoacylase
RG65_RS02260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RG65_RS02265	COG0549	Belongs to the carbamate kinase family
RG65_RS02275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RG65_RS02280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG65_RS02285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RG65_RS02290	COG3829	transcription factor binding
RG65_RS02295	COG2080	2 iron, 2 sulfur cluster binding
RG65_RS02300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG65_RS02305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG65_RS02315	COG4942	peptidase
RG65_RS02345	COG2801	Transposase and inactivated derivatives
RG65_RS02430	COG2197	response regulator
RG65_RS02435	COG2197	response regulator
RG65_RS02440	COG0741	lytic transglycosylase activity
RG65_RS02450	COG0457	Tetratricopeptide repeat
RG65_RS02450	COG3710	Transcriptional regulator
RG65_RS02455	COG0457	Tetratricopeptide repeat
RG65_RS02480	COG3710	Transcriptional regulator
RG65_RS02485	COG2771	luxR family
RG65_RS02490	COG0814	amino acid
RG65_RS02495	COG0183	Belongs to the thiolase family
RG65_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS02510	COG2814	Major facilitator Superfamily
RG65_RS02515	COG1794	racemase activity, acting on amino acids and derivatives
RG65_RS02520	COG0583	DNA-binding transcription factor activity
RG65_RS02530	COG1609	Transcriptional regulator
RG65_RS02550	COG0667	Aldo Keto reductase
RG65_RS02560	COG0861	Integral membrane protein TerC family
RG65_RS02585	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
RG65_RS02600	COG2165	general secretion pathway protein
RG65_RS02605	COG4795	General secretion pathway protein
RG65_RS02615	COG4967	type IV pilus modification protein PilV
RG65_RS02620	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RG65_RS02625	COG1025	Belongs to the peptidase M16 family
RG65_RS02630	COG1074	ATP-dependent DNA helicase activity
RG65_RS02635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RG65_RS02640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RG65_RS02640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RG65_RS02645	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG65_RS02685	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RG65_RS02690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RG65_RS02695	COG2166	iron-sulfur cluster assembly
RG65_RS02700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RG65_RS02710	COG0583	DNA-binding transcription factor activity
RG65_RS02715	COG2363	Small membrane protein
RG65_RS02725	COG1349	DNA-binding transcription factor activity
RG65_RS02735	COG1070	Carbohydrate kinase
RG65_RS02745	COG0738	Major facilitator superfamily
RG65_RS02750	COG0235	Class ii aldolase
RG65_RS02755	COG1454	alcohol dehydrogenase
RG65_RS02765	COG1760	l-serine dehydratase
RG65_RS02770	COG0814	amino acid
RG65_RS02775	COG1611	Belongs to the LOG family
RG65_RS02795	COG3098	single-species biofilm formation
RG65_RS02800	COG0564	pseudouridine synthase activity
RG65_RS02805	COG0716	FMN binding
RG65_RS02810	COG2271	Major facilitator Superfamily
RG65_RS02815	COG4948	Mandelate Racemase Muconate Lactonizing
RG65_RS02820	COG4948	Mandelate Racemase Muconate Lactonizing
RG65_RS02825	COG2205	protein histidine kinase activity
RG65_RS02825	COG4999	Histidine kinase
RG65_RS02825	COG3437	response regulator, receiver
RG65_RS02825	COG3850	Histidine kinase
RG65_RS02835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG65_RS02840	COG2336	PFAM SpoVT AbrB
RG65_RS02845	COG2337	Toxic component of a toxin-antitoxin (TA) module
RG65_RS02850	COG3956	TIGRFAM MazG family protein
RG65_RS02865	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RG65_RS02875	COG0602	queuosine metabolic process
RG65_RS02880	COG1070	Carbohydrate kinase
RG65_RS02885	COG2223	nitrite transmembrane transporter activity
RG65_RS02890	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS02895	COG0277	FAD linked oxidase domain protein
RG65_RS02900	COG0477	Major facilitator Superfamily
RG65_RS02905	COG2086	electron transfer activity
RG65_RS02910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RG65_RS02915	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RG65_RS02920	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG65_RS02925	COG0644	oxidoreductase
RG65_RS02930	COG0720	synthase
RG65_RS02955	COG1203	CRISPR-associated helicase, Cas3
RG65_RS02975	COG1857	crispr-associated protein
RG65_RS02990	COG1518	maintenance of DNA repeat elements
RG65_RS02995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG65_RS03000	COG2234	aminopeptidase activity
RG65_RS03055	COG4942	peptidase
RG65_RS03055	COG1388	LysM domain
RG65_RS03060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG65_RS03075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RG65_RS03085	COG2610	gluconate transmembrane transporter activity
RG65_RS03090	COG3622	Belongs to the hyi family
RG65_RS03095	COG0235	Class ii aldolase
RG65_RS03100	COG3395	kinase activity
RG65_RS03105	COG2084	Dehydrogenase
RG65_RS03110	COG1349	DNA-binding transcription factor activity
RG65_RS03115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG65_RS03135	COG3604	Transcriptional regulator
RG65_RS03140	COG0309	Hydrogenase expression formation protein (HypE)
RG65_RS03145	COG0409	Hydrogenase expression formation protein
RG65_RS03150	COG0298	carbon dioxide binding
RG65_RS03155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RG65_RS03160	COG0375	protein maturation
RG65_RS03175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS03180	COG0651	ATP synthesis coupled electron transport
RG65_RS03185	COG0650	Formate hydrogenlyase subunit 4
RG65_RS03190	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RG65_RS03190	COG3261	NADH dehydrogenase
RG65_RS03195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG65_RS03200	COG3260	NADH ubiquinone oxidoreductase 20
RG65_RS03210	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG65_RS03220	COG5499	transcription regulator containing HTH domain
RG65_RS03225	COG2723	6-phospho-beta-galactosidase activity
RG65_RS03230	COG1263	PTS System
RG65_RS03230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS03235	COG1609	Transcriptional regulator
RG65_RS03240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS03245	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RG65_RS03265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RG65_RS03265	COG0517	IMP dehydrogenase activity
RG65_RS03270	COG1349	DNA-binding transcription factor activity
RG65_RS03275	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS03290	COG3732	PTS system glucitol sorbitol-specific
RG65_RS03295	COG3730	PTS system glucitol sorbitol-specific
RG65_RS03300	COG2951	lytic endotransglycosylase activity
RG65_RS03305	COG1546	Belongs to the CinA family
RG65_RS03330	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RG65_RS03360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG65_RS03365	COG1238	metal cluster binding
RG65_RS03380	COG2814	Major facilitator Superfamily
RG65_RS03385	COG1566	PFAM secretion protein HlyD family protein
RG65_RS03390	COG1846	Transcriptional regulator
RG65_RS03400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RG65_RS03405	COG2814	Major facilitator Superfamily
RG65_RS03410	COG2113	Glycine betaine
RG65_RS03415	COG4176	ABC-type proline glycine betaine transport system permease component
RG65_RS03420	COG4175	Glycine betaine
RG65_RS03425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG65_RS03430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG65_RS03440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG65_RS03445	COG4575	ribosome binding
RG65_RS03460	COG2916	Histone family protein nucleoid-structuring protein H-NS
RG65_RS03465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG65_RS03470	COG0640	Transcriptional regulator
RG65_RS03475	COG0401	homolog of Blt101
RG65_RS03480	COG1652	LysM domain
RG65_RS03485	COG1802	Transcriptional regulator
RG65_RS03490	COG1113	amino acid transport
RG65_RS03495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG65_RS03500	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS03505	COG0579	oxidoreductase
RG65_RS03515	COG0366	Alpha amylase catalytic
RG65_RS03550	COG3468	outer membrane autotransporter barrel domain protein
RG65_RS03570	COG3409	Peptidoglycan-binding domain 1 protein
RG65_RS03570	COG3429	Glucose-6-phosphate dehydrogenase subunit
RG65_RS03590	COG1475	DNA binding
RG65_RS03600	COG0582	viral genome integration into host DNA
RG65_RS03615	COG2867	negative regulation of translational initiation
RG65_RS03625	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG65_RS03630	COG0497	DNA recombination
RG65_RS03655	COG4536	flavin adenine dinucleotide binding
RG65_RS03660	COG4137	Cytochrome C assembly protein
RG65_RS03665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RG65_RS03745	COG4695	Portal protein
RG65_RS03795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG65_RS03845	COG2885	chlorophyll binding
RG65_RS03850	COG2199	diguanylate cyclase activity
RG65_RS03865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG65_RS03870	COG0287	Prephenate dehydrogenase
RG65_RS03870	COG1605	Chorismate mutase
RG65_RS03875	COG1605	Chorismate mutase
RG65_RS03875	COG0077	Prephenate dehydratase
RG65_RS03880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RG65_RS03890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG65_RS03895	COG0564	pseudouridine synthase activity
RG65_RS03900	COG1496	oxidoreductase activity
RG65_RS03905	COG0542	response to heat
RG65_RS03940	COG0477	Major facilitator Superfamily
RG65_RS03945	COG5544	Lipoprotein
RG65_RS03950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG65_RS03955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG65_RS03955	COG1042	CoA-binding domain protein
RG65_RS03955	COG0045	succinate-CoA ligase (ADP-forming) activity
RG65_RS03960	COG3148	PFAM DTW domain containing protein
RG65_RS03965	COG3118	belongs to the thioredoxin family
RG65_RS03970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG65_RS03990	COG0583	DNA-binding transcription factor activity
RG65_RS03995	COG0513	Belongs to the DEAD box helicase family
RG65_RS04005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RG65_RS04015	COG1595	DNA-templated transcription, initiation
RG65_RS04020	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
RG65_RS04025	COG3026	antisigma factor binding
RG65_RS04030	COG3086	response to oxidative stress
RG65_RS04040	COG0681	Belongs to the peptidase S26 family
RG65_RS04065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RG65_RS04090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS04095	COG1737	Transcriptional regulator
RG65_RS04100	COG0560	Phosphoserine phosphatase
RG65_RS04125	COG2205	protein histidine kinase activity
RG65_RS04130	COG3170	Tfp pilus assembly protein FimV
RG65_RS04135	COG2204	response regulator
RG65_RS04140	COG0347	Belongs to the P(II) protein family
RG65_RS04145	COG1017	nitric oxide dioxygenase activity
RG65_RS04145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG65_RS04160	COG1940	carbohydrate kinase activity
RG65_RS04165	COG0457	Tetratricopeptide repeat
RG65_RS04170	COG1879	ABC-type sugar transport system periplasmic component
RG65_RS04175	COG1129	ABC transporter
RG65_RS04180	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG65_RS04185	COG1063	alcohol dehydrogenase
RG65_RS04190	COG2017	converts alpha-aldose to the beta-anomer
RG65_RS04195	COG2259	Doxx family
RG65_RS04220	COG4638	Rieske (2fe-2S)
RG65_RS04225	COG0583	DNA-binding transcription factor activity
RG65_RS04230	COG2814	Major facilitator Superfamily
RG65_RS04235	COG3711	transcriptional antiterminator
RG65_RS04240	COG1073	alpha beta
RG65_RS04245	COG0483	inositol monophosphate 1-phosphatase activity
RG65_RS04265	COG0822	iron-sulfur transferase activity
RG65_RS04285	COG0633	Ferredoxin
RG65_RS04290	COG2975	iron-sulfur cluster assembly
RG65_RS04305	COG2897	thiosulfate sulfurtransferase activity
RG65_RS04310	COG2373	Large extracellular alpha-helical protein
RG65_RS04315	COG4953	penicillin-binding protein 1C
RG65_RS04345	COG2976	Protein conserved in bacteria
RG65_RS04360	COG1645	bacterial-type flagellum-dependent swarming motility
RG65_RS04370	COG0517	IMP dehydrogenase activity
RG65_RS04370	COG0516	GMP reductase activity
RG65_RS04385	COG3133	Outer membrane lipoprotein
RG65_RS04405	COG2200	EAL domain
RG65_RS04410	COG0248	Ppx GppA phosphatase
RG65_RS04415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RG65_RS04420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RG65_RS04440	COG2233	PERMEase
RG65_RS04450	COG1393	Belongs to the ArsC family
RG65_RS04455	COG4783	chaperone-mediated protein folding
RG65_RS04460	COG0628	permease
RG65_RS04465	COG2116	formate transmembrane transporter activity
RG65_RS04470	COG3604	Transcriptional regulator
RG65_RS04475	COG0651	ATP synthesis coupled electron transport
RG65_RS04480	COG0651	ATP synthesis coupled electron transport
RG65_RS04485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS04490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RG65_RS04495	COG2716	regulation of RNA biosynthetic process
RG65_RS04505	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RG65_RS04530	COG2321	neutral zinc metallopeptidase
RG65_RS04540	COG0400	carboxylic ester hydrolase activity
RG65_RS04555	COG1393	Belongs to the ArsC family
RG65_RS04570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG65_RS04575	COG3850	Histidine kinase
RG65_RS04580	COG0493	'glutamate synthase
RG65_RS04580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS04590	COG5342	invasion associated locus B
RG65_RS04595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RG65_RS04600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG65_RS04605	COG0280	phosphate acetyltransferase
RG65_RS04605	COG0281	malic enzyme
RG65_RS04610	COG4810	utilization protein
RG65_RS04615	COG4917	ethanolamine utilization protein
RG65_RS04620	COG4766	ethanolamine catabolic process
RG65_RS04625	COG4812	Cobalamin adenosyltransferase
RG65_RS04630	COG0280	phosphate acetyltransferase
RG65_RS04635	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG65_RS04640	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
RG65_RS04645	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS04650	COG4820	ethanolamine utilization protein (EutJ)
RG65_RS04655	COG1454	alcohol dehydrogenase
RG65_RS04660	COG3192	ethanolamine utilization protein
RG65_RS04665	COG4819	ethanolamine utilization protein
RG65_RS04670	COG4303	Ethanolamine ammonia lyase large subunit
RG65_RS04680	COG4816	utilization protein
RG65_RS04685	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG65_RS04690	COG2207	Transcriptional regulator
RG65_RS04700	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG65_RS04720	COG2837	iron assimilation
RG65_RS04725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG65_RS04730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS04730	COG1263	PTS System
RG65_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS04750	COG4150	thiosulfate binding
RG65_RS04755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RG65_RS04760	COG4208	sulfate ABC transporter
RG65_RS04765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RG65_RS04770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG65_RS04785	COG2190	(PTS) system
RG65_RS04790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG65_RS04795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS04800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RG65_RS04825	COG3530	Putative quorum-sensing-regulated virulence factor
RG65_RS04830	COG0385	Bile acid
RG65_RS04835	COG0583	DNA-binding transcription factor activity
RG65_RS04845	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RG65_RS04850	COG2211	Major facilitator Superfamily
RG65_RS04860	COG0583	DNA-binding transcription factor activity
RG65_RS04890	COG3415	Transposase
RG65_RS04895	COG3415	Transposase
RG65_RS04910	COG2200	EAL domain
RG65_RS04910	COG2199	diguanylate cyclase activity
RG65_RS04915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG65_RS04945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS04950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS04955	COG0006	proline dipeptidase activity
RG65_RS04960	COG1363	Peptidase, m42
RG65_RS04970	COG2207	Transcriptional regulator
RG65_RS04975	COG3279	Response regulator of the LytR AlgR family
RG65_RS04980	COG3275	phosphorelay sensor kinase activity
RG65_RS04985	COG0436	Aminotransferase
RG65_RS04995	COG1560	Kdo2-lipid A biosynthetic process
RG65_RS05030	COG0028	Belongs to the TPP enzyme family
RG65_RS05035	COG0679	Auxin Efflux Carrier
RG65_RS05040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RG65_RS05045	COG2205	protein histidine kinase activity
RG65_RS05045	COG2198	Histidine kinase
RG65_RS05045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS05045	COG0784	Response regulator, receiver
RG65_RS05050	COG2197	response regulator
RG65_RS05055	COG1566	PFAM secretion protein HlyD family protein
RG65_RS05060	COG0477	Major facilitator Superfamily
RG65_RS05070	COG2610	gluconate transmembrane transporter activity
RG65_RS05075	COG0583	DNA-binding transcription factor activity
RG65_RS05085	COG2116	formate transmembrane transporter activity
RG65_RS05090	COG2853	Lipoprotein
RG65_RS05105	COG2067	long-chain fatty acid transport protein
RG65_RS05115	COG3691	Protein conserved in bacteria
RG65_RS05130	COG2062	phosphohistidine phosphatase, SixA
RG65_RS05135	COG3539	Fimbrial protein
RG65_RS05140	COG3188	usher protein
RG65_RS05145	COG3121	Chaperone
RG65_RS05150	COG3539	Fimbrial protein
RG65_RS05155	COG3539	Fimbrial protein
RG65_RS05160	COG3539	Fimbrial protein
RG65_RS05190	COG0730	response to heat
RG65_RS05195	COG3101	peptidyl-lysine hydroxylation
RG65_RS05210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG65_RS05225	COG2814	Major facilitator Superfamily
RG65_RS05240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG65_RS05250	COG0586	Pfam SNARE associated Golgi protein
RG65_RS05260	COG0285	dihydrofolate synthase activity
RG65_RS05265	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
RG65_RS05275	COG1286	toxin biosynthetic process
RG65_RS05280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RG65_RS05285	COG0163	prenyltransferase activity
RG65_RS05290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS05295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS05300	COG4215	(ABC) transporter
RG65_RS05305	COG4160	amino acid transport
RG65_RS05310	COG4598	ABC transporter
RG65_RS05315	COG5464	transposase or invertase
RG65_RS05320	COG1090	epimerase
RG65_RS05325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RG65_RS05330	COG0625	glutathione transferase activity
RG65_RS05335	COG0625	glutathione transferase activity
RG65_RS05340	COG0622	Phosphoesterase
RG65_RS05345	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RG65_RS05350	COG1288	antiporter activity
RG65_RS05355	COG0857	belongs to the CobB CobQ family
RG65_RS05355	COG0280	phosphate acetyltransferase
RG65_RS05360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RG65_RS05380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG65_RS05385	COG0471	metal ion transport
RG65_RS05385	COG0490	domain, Protein
RG65_RS05395	COG0436	Aminotransferase
RG65_RS05405	COG0583	DNA-binding transcription factor activity
RG65_RS05425	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RG65_RS05430	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RG65_RS05435	COG1034	ATP synthesis coupled electron transport
RG65_RS05450	COG0839	Belongs to the complex I subunit 6 family
RG65_RS05460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RG65_RS05465	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG65_RS05495	COG2153	protein acetylation
RG65_RS05500	COG4575	ribosome binding
RG65_RS05505	COG1169	isochorismate synthase
RG65_RS05520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RG65_RS05530	COG0318	PFAM AMP-dependent synthetase and ligase
RG65_RS05600	COG5464	transposase or invertase
RG65_RS05605	COG0247	lactate metabolic process
RG65_RS05615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG65_RS05620	COG2271	Major facilitator Superfamily
RG65_RS05625	COG0584	glycerophosphoryl diester phosphodiesterase
RG65_RS05630	COG0583	DNA-binding transcription factor activity
RG65_RS05640	COG3642	lipopolysaccharide core region biosynthetic process
RG65_RS05645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG65_RS05650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG65_RS05655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RG65_RS05665	COG3468	outer membrane autotransporter barrel domain protein
RG65_RS05675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RG65_RS05680	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
RG65_RS05685	COG3234	Protein of unknown function (DUF1175)
RG65_RS05695	COG5445	Predicted secreted protein (DUF2300)
RG65_RS05700	COG4676	Protein conserved in bacteria
RG65_RS05705	COG0784	Response regulator, receiver
RG65_RS05705	COG2205	protein histidine kinase activity
RG65_RS05715	COG2197	response regulator
RG65_RS05720	COG2198	Histidine kinase
RG65_RS05720	COG0642	Histidine kinase
RG65_RS05735	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG65_RS05740	COG1477	protein flavinylation
RG65_RS05745	COG2169	Transcriptional regulator
RG65_RS05745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG65_RS05750	COG3145	DNA-N1-methyladenine dioxygenase activity
RG65_RS05755	COG4615	Cyclic peptide transporter
RG65_RS05775	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS05775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS05780	COG3062	negative regulation of establishment of protein localization
RG65_RS05790	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS05795	COG0348	domain, Protein
RG65_RS05800	COG3043	anaerobic respiration
RG65_RS05805	COG3005	denitrification pathway
RG65_RS05810	COG4133	protoheme IX ABC transporter activity
RG65_RS05815	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG65_RS05820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG65_RS05825	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RG65_RS05835	COG1138	Cytochrome C-type biogenesis protein
RG65_RS05840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RG65_RS05845	COG4235	cytochrome complex assembly
RG65_RS05845	COG3088	subunit of a heme lyase
RG65_RS05850	COG2197	response regulator
RG65_RS05860	COG3468	outer membrane autotransporter barrel domain protein
RG65_RS05865	COG3468	outer membrane autotransporter barrel domain protein
RG65_RS05875	COG3083	sulfuric ester hydrolase activity
RG65_RS05895	COG1061	Type III restriction enzyme res subunit
RG65_RS05905	COG1187	pseudouridine synthase activity
RG65_RS05910	COG2814	Major facilitator Superfamily
RG65_RS05925	COG4172	Belongs to the ABC transporter superfamily
RG65_RS05930	COG4239	(ABC) transporter, permease
RG65_RS05935	COG4174	ABC transporter (Permease)
RG65_RS05940	COG4166	transmembrane transport
RG65_RS05945	COG2200	EAL domain
RG65_RS05950	COG0791	NLP P60 protein
RG65_RS05955	COG0671	phosphoesterase, PA-phosphatase related
RG65_RS05960	COG0523	cobalamin synthesis protein
RG65_RS05965	COG0246	Mannitol dehydrogenase
RG65_RS05980	COG2814	Major facilitator Superfamily
RG65_RS05985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS05985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS05990	COG1105	Belongs to the carbohydrate kinase PfkB family
RG65_RS05995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS05995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS05995	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RG65_RS06005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG65_RS06010	COG2313	pseudouridylate synthase activity
RG65_RS06015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG65_RS06020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG65_RS06030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RG65_RS06035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG65_RS06035	COG1522	sequence-specific DNA binding
RG65_RS06045	COG2855	membrane
RG65_RS06050	COG0583	DNA-binding transcription factor activity
RG65_RS06060	COG0833	amino acid
RG65_RS06070	COG4771	TonB-dependent receptor
RG65_RS06080	COG0560	Phosphoserine phosphatase
RG65_RS06085	COG1760	l-serine dehydratase
RG65_RS06095	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RG65_RS06110	COG2311	Membrane
RG65_RS06120	COG1609	Transcriptional regulator
RG65_RS06125	COG1879	ABC-type sugar transport system periplasmic component
RG65_RS06130	COG1129	ABC transporter
RG65_RS06135	COG4211	Belongs to the binding-protein-dependent transport system permease family
RG65_RS06140	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RG65_RS06140	COG0167	dihydroorotate dehydrogenase activity
RG65_RS06145	COG0493	'glutamate synthase
RG65_RS06155	COG2949	membrane
RG65_RS06165	COG1346	cytolysis
RG65_RS06175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG65_RS06200	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS06205	COG0586	Pfam SNARE associated Golgi protein
RG65_RS06215	COG1686	Belongs to the peptidase S11 family
RG65_RS06220	COG0277	FAD linked oxidase domain protein
RG65_RS06225	COG1472	Belongs to the glycosyl hydrolase 3 family
RG65_RS06230	COG1732	Glycine betaine
RG65_RS06235	COG1174	glycine betaine transport
RG65_RS06240	COG1125	glycine betaine transport
RG65_RS06245	COG1174	glycine betaine transport
RG65_RS06255	COG0789	Transcriptional regulator
RG65_RS06260	COG3275	phosphorelay sensor kinase activity
RG65_RS06265	COG3279	Response regulator of the LytR AlgR family
RG65_RS06270	COG4807	Protein conserved in bacteria
RG65_RS06275	COG4808	Protein conserved in bacteria
RG65_RS06280	COG4715	Zinc finger, swim domain protein
RG65_RS06285	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RG65_RS06290	COG2425	protein containing a von Willebrand factor type A (vWA) domain
RG65_RS06295	COG0714	Associated with various cellular activities
RG65_RS06315	COG3831	ATPase activity
RG65_RS06320	COG3831	ATPase activity
RG65_RS06330	COG0489	protein tyrosine kinase activity
RG65_RS06345	COG3539	Fimbrial protein
RG65_RS06350	COG3121	Chaperone
RG65_RS06355	COG3188	usher protein
RG65_RS06360	COG3539	Fimbrial protein
RG65_RS06365	COG5455	response to cobalt ion
RG65_RS06385	COG0351	phosphomethylpyrimidine kinase
RG65_RS06390	COG3757	hydrolase, family 25
RG65_RS06395	COG2188	Transcriptional regulator
RG65_RS06400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG65_RS06405	COG1397	ADP-ribosylglycohydrolase
RG65_RS06410	COG2211	Major facilitator Superfamily
RG65_RS06415	COG1830	Aldolase
RG65_RS06430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS06435	COG3414	Phosphotransferase system galactitol-specific IIB component
RG65_RS06440	COG3775	system Galactitol-specific IIC component
RG65_RS06445	COG1063	alcohol dehydrogenase
RG65_RS06495	COG2801	Transposase and inactivated derivatives
RG65_RS06525	COG0826	peptidase U32
RG65_RS06535	COG3609	addiction module antidote protein, CC2985 family
RG65_RS06550	COG0745	RESPONSE REGULATOR receiver
RG65_RS06555	COG2205	protein histidine kinase activity
RG65_RS06590	COG4245	von Willebrand factor, type A
RG65_RS06595	COG0631	protein serine/threonine phosphatase activity
RG65_RS06600	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
RG65_RS06605	COG0443	Heat shock 70 kDa protein
RG65_RS06610	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RG65_RS06615	COG5002	protein histidine kinase activity
RG65_RS06615	COG5001	Diguanylate cyclase
RG65_RS06615	COG3447	MASE1 domain protein
RG65_RS06620	COG0572	uridine kinase
RG65_RS06630	COG2982	Protein involved in outer membrane biogenesis
RG65_RS06640	COG1253	flavin adenine dinucleotide binding
RG65_RS06645	COG1596	polysaccharide export
RG65_RS06650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG65_RS06655	COG0489	protein tyrosine kinase activity
RG65_RS06655	COG3206	protein involved in exopolysaccharide biosynthesis
RG65_RS06660	COG0463	Glycosyl transferase, family 2
RG65_RS06665	COG1045	serine acetyltransferase
RG65_RS06670	COG0438	transferase activity, transferring glycosyl groups
RG65_RS06680	COG1216	Glycosyl transferase, family 2
RG65_RS06685	COG0110	maltose O-acetyltransferase activity
RG65_RS06690	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RG65_RS06695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG65_RS06700	COG1051	belongs to the nudix hydrolase family
RG65_RS06705	COG0297	glycogen (starch) synthase activity
RG65_RS06710	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RG65_RS06710	COG0662	Cupin 2, conserved barrel domain protein
RG65_RS06715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RG65_RS06720	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RG65_RS06725	COG2244	polysaccharide biosynthetic process
RG65_RS06735	COG2327	Polysaccharide pyruvyl transferase
RG65_RS06740	COG0438	transferase activity, transferring glycosyl groups
RG65_RS06750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG65_RS06760	COG1088	dTDP-glucose 4,6-dehydratase activity
RG65_RS06765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RG65_RS06800	COG0562	UDP-galactopyranose mutase
RG65_RS06810	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RG65_RS06820	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG65_RS06845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RG65_RS06850	COG0131	Imidazoleglycerol-phosphate dehydratase
RG65_RS06850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG65_RS06880	COG2161	toxin-antitoxin pair type II binding
RG65_RS06885	COG4115	mRNA cleavage
RG65_RS06890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG65_RS06895	COG0583	DNA-binding transcription factor activity
RG65_RS06900	COG0531	amino acid
RG65_RS06905	COG2391	methyltransferase activity
RG65_RS06910	COG0425	Belongs to the sulfur carrier protein TusA family
RG65_RS06915	COG2925	Exonuclease
RG65_RS06920	COG1686	Belongs to the peptidase S11 family
RG65_RS06930	COG1289	transmembrane transporter activity
RG65_RS06960	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS06960	COG1454	alcohol dehydrogenase
RG65_RS06975	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
RG65_RS06990	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RG65_RS07050	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
RG65_RS07065	COG1376	ErfK ybiS ycfS ynhG family protein
RG65_RS07075	COG0583	DNA-binding transcription factor activity
RG65_RS07080	COG0583	DNA-binding transcription factor activity
RG65_RS07090	COG0534	Mate efflux family protein
RG65_RS07105	COG0217	transcriptional regulatory protein
RG65_RS07110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RG65_RS07115	COG0477	Major facilitator Superfamily
RG65_RS07125	COG1470	cell adhesion involved in biofilm formation
RG65_RS07125	COG1388	LysM domain
RG65_RS07155	COG3038	cytochrome b561
RG65_RS07160	COG3443	Belongs to the bacterial solute-binding protein 9 family
RG65_RS07175	COG2351	hydroxyisourate hydrolase activity
RG65_RS07180	COG0745	RESPONSE REGULATOR receiver
RG65_RS07185	COG2205	protein histidine kinase activity
RG65_RS07200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG65_RS07215	COG1418	mRNA catabolic process
RG65_RS07220	COG0270	DNA (cytosine-5-)-methyltransferase activity
RG65_RS07225	COG3727	T/G mismatch-specific endonuclease activity
RG65_RS07230	COG0697	spore germination
RG65_RS07235	COG2354	Protein conserved in bacteria
RG65_RS07240	COG5475	Uncharacterized small protein (DUF2158)
RG65_RS07250	COG3706	GGDEF domain
RG65_RS07275	COG2197	response regulator
RG65_RS07280	COG1684	flagellar biosynthetic protein fliR
RG65_RS07285	COG1987	bacterial-type flagellum assembly
RG65_RS07290	COG1338	Plays a role in the flagellum-specific transport system
RG65_RS07295	COG3190	flagellar
RG65_RS07300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG65_RS07305	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG65_RS07310	COG1580	Controls the rotational direction of flagella during chemotaxis
RG65_RS07315	COG3144	bacterial-type flagellum assembly
RG65_RS07320	COG2882	bacterial-type flagellum organization
RG65_RS07325	COG1157	protein secretion by the type III secretion system
RG65_RS07330	COG1317	bacterial-type flagellum organization
RG65_RS07335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RG65_RS07340	COG1766	The M ring may be actively involved in energy transduction
RG65_RS07355	COG2076	Multidrug Resistance protein
RG65_RS07360	COG1881	PFAM PEBP family protein
RG65_RS07365	COG2207	Transcriptional regulator
RG65_RS07380	COG0675	Transposase, IS605 OrfB family
RG65_RS07385	COG2135	peptidase activity
RG65_RS07390	COG0425	Belongs to the sulfur carrier protein TusA family
RG65_RS07395	COG2391	methyltransferase activity
RG65_RS07410	COG0366	Alpha amylase catalytic
RG65_RS07420	COG1516	flagellar protein fliS
RG65_RS07425	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RG65_RS07435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RG65_RS07440	COG1191	sigma factor activity
RG65_RS07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS07460	COG0765	amino acid transport
RG65_RS07465	COG1126	abc transporter atp-binding protein
RG65_RS07470	COG2197	response regulator
RG65_RS07485	COG2197	response regulator
RG65_RS07515	COG3318	Belongs to the UPF0149 family
RG65_RS07515	COG3012	SEC-C Motif Domain Protein
RG65_RS07520	COG0814	amino acid
RG65_RS07530	COG1528	Iron-storage protein
RG65_RS07550	COG1528	Iron-storage protein
RG65_RS07560	COG1879	ABC-type sugar transport system periplasmic component
RG65_RS07565	COG1129	ABC transporter
RG65_RS07570	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG65_RS07575	COG1877	trehalose-phosphatase activity
RG65_RS07585	COG0589	response to stress
RG65_RS07600	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RG65_RS07605	COG1360	Flagellar Motor Protein
RG65_RS07610	COG0643	Histidine kinase
RG65_RS07610	COG2198	Histidine kinase
RG65_RS07615	COG0835	chemotaxis
RG65_RS07620	COG0840	transmembrane signaling receptor activity
RG65_RS07625	COG0840	transmembrane signaling receptor activity
RG65_RS07630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RG65_RS07635	COG2201	protein-glutamate methylesterase activity
RG65_RS07640	COG0745	RESPONSE REGULATOR receiver
RG65_RS07645	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RG65_RS07650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG65_RS07655	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RG65_RS07665	COG3755	Protein conserved in bacteria
RG65_RS07680	COG3102	Protein conserved in bacteria
RG65_RS07690	COG3005	denitrification pathway
RG65_RS07695	COG0243	molybdopterin cofactor binding
RG65_RS07720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
RG65_RS07725	COG1801	Protein of unknown function DUF72
RG65_RS07730	COG1335	isochorismatase
RG65_RS07740	COG0494	nUDIX hydrolase
RG65_RS07745	COG0217	transcriptional regulatory protein
RG65_RS07775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RG65_RS07785	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RG65_RS07790	COG0739	heme binding
RG65_RS07795	COG1560	Kdo2-lipid A biosynthetic process
RG65_RS07800	COG0469	pyruvate kinase activity
RG65_RS07805	COG1737	Transcriptional regulator
RG65_RS07820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RG65_RS07825	COG0129	dihydroxy-acid dehydratase activity
RG65_RS07830	COG0800	Aldolase
RG65_RS07840	COG3141	response to X-ray
RG65_RS07860	COG2979	Protein of unknown function (DUF533)
RG65_RS07870	COG1770	oligopeptidase
RG65_RS07875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG65_RS07880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG65_RS07890	COG2372	response to copper ion
RG65_RS07895	COG1276	copper resistance
RG65_RS07910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RG65_RS07930	COG3008	intermembrane lipid transfer
RG65_RS07935	COG2995	paraquat-inducible protein a
RG65_RS07940	COG1956	GAF domain-containing protein
RG65_RS07950	COG0793	Belongs to the peptidase S41A family
RG65_RS07960	COG2814	Major facilitator Superfamily
RG65_RS07965	COG1414	Transcriptional regulator
RG65_RS08000	COG2226	methyltransferase
RG65_RS08020	COG3716	PTS system mannose fructose sorbose family IID component
RG65_RS08025	COG3715	PTS system
RG65_RS08030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS08030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS08045	COG1253	flavin adenine dinucleotide binding
RG65_RS08050	COG2200	EAL domain
RG65_RS08055	COG1760	l-serine dehydratase
RG65_RS08065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG65_RS08085	COG0251	oxidation-reduction process
RG65_RS08090	COG1199	ATP-dependent helicase activity
RG65_RS08095	COG1214	PFAM Peptidase M22, glycoprotease
RG65_RS08100	COG3065	identical protein binding
RG65_RS08105	COG0318	PFAM AMP-dependent synthetase and ligase
RG65_RS08110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RG65_RS08115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG65_RS08120	COG4638	Rieske (2fe-2S)
RG65_RS08125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG65_RS08130	COG0473	3-isopropylmalate dehydrogenase activity
RG65_RS08135	COG0583	DNA-binding transcription factor activity
RG65_RS08150	COG0675	Transposase, IS605 OrfB family
RG65_RS08155	COG2261	transglycosylase associated protein
RG65_RS08170	COG2199	diguanylate cyclase activity
RG65_RS08170	COG2203	Gaf domain
RG65_RS08175	COG3042	response to heat
RG65_RS08180	COG3189	MarR family transcriptional regulator
RG65_RS08185	COG2807	transmembrane transport
RG65_RS08190	COG2207	Transcriptional regulator
RG65_RS08205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG65_RS08210	COG2199	diguanylate cyclase activity
RG65_RS08215	COG2199	diguanylate cyclase activity
RG65_RS08225	COG2766	serine protein kinase
RG65_RS08230	COG3713	MltA-interacting MipA family protein
RG65_RS08235	COG0656	L-ascorbic acid biosynthetic process
RG65_RS08240	COG0676	glucose-6-phosphate 1-epimerase activity
RG65_RS08245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG65_RS08255	COG3139	Protein of unknown function (DUF1315)
RG65_RS08260	COG1335	isochorismatase
RG65_RS08265	COG0252	asparaginase activity
RG65_RS08270	COG0616	signal peptide processing
RG65_RS08275	COG0778	Nitroreductase
RG65_RS08285	COG0709	Synthesizes selenophosphate from selenide and ATP
RG65_RS08290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG65_RS08305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RG65_RS08315	COG0494	nUDIX hydrolase
RG65_RS08320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RG65_RS08325	COG2897	thiosulfate sulfurtransferase activity
RG65_RS08330	COG4136	ATPase activity
RG65_RS08335	COG4135	transport system, permease component
RG65_RS08340	COG4134	Bacterial extracellular solute-binding protein
RG65_RS08345	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG65_RS08350	COG0398	Pfam SNARE associated Golgi protein
RG65_RS08360	COG0398	Pfam SNARE associated Golgi protein
RG65_RS08365	COG0708	Exodeoxyribonuclease III
RG65_RS08400	COG3678	ATP-independent chaperone mediated protein folding
RG65_RS08410	COG0322	excinuclease ABC activity
RG65_RS08420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG65_RS08430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG65_RS08435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG65_RS08440	COG1447	Phosphotransferase system cellobiose-specific component IIA
RG65_RS08445	COG1917	Cupin 2, conserved barrel domain protein
RG65_RS08445	COG2169	Transcriptional regulator
RG65_RS08450	COG1486	melibiose metabolic process
RG65_RS08460	COG0753	catalase activity
RG65_RS08475	COG1823	symporter activity
RG65_RS08480	COG1988	membrane-bound metal-dependent
RG65_RS08485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG65_RS08495	COG3001	Fructosamine kinase
RG65_RS08505	COG1105	Belongs to the carbohydrate kinase PfkB family
RG65_RS08510	COG3137	Salt-induced outer membrane protein
RG65_RS08580	COG0386	Belongs to the glutathione peroxidase family
RG65_RS08590	COG0791	NLP P60 protein
RG65_RS08595	COG2200	EAL domain
RG65_RS08605	COG4256	Hemin uptake protein
RG65_RS08610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG65_RS08625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG65_RS08625	COG0574	Belongs to the PEP-utilizing enzyme family
RG65_RS08630	COG0318	PFAM AMP-dependent synthetase and ligase
RG65_RS08635	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG65_RS08640	COG0644	oxidoreductase
RG65_RS08645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RG65_RS08650	COG2086	electron transfer activity
RG65_RS08660	COG1917	Cupin 2, conserved barrel domain protein
RG65_RS08660	COG2207	Transcriptional regulator
RG65_RS08665	COG1960	acyl-CoA dehydrogenase activity
RG65_RS08670	COG4670	ketone body catabolic process
RG65_RS08685	COG2271	Major facilitator Superfamily
RG65_RS08690	COG0738	Major facilitator superfamily
RG65_RS08705	COG0628	permease
RG65_RS08710	COG0277	FAD linked oxidase domain protein
RG65_RS08710	COG0247	lactate metabolic process
RG65_RS08715	COG2050	protein possibly involved in aromatic compounds catabolism
RG65_RS08725	COG0316	Belongs to the HesB IscA family
RG65_RS08730	COG0719	Fe-S assembly protein
RG65_RS08735	COG0396	ATPase activity
RG65_RS08740	COG0719	Fe-S assembly protein
RG65_RS08755	COG1376	ErfK ybiS ycfS ynhG family protein
RG65_RS08760	COG4238	major outer membrane lipoprotein
RG65_RS08765	COG0469	pyruvate kinase activity
RG65_RS08775	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS08780	COG2414	aldehyde ferredoxin oxidoreductase
RG65_RS08790	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS08795	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RG65_RS08805	COG4529	Protein conserved in bacteria
RG65_RS08825	COG3468	outer membrane autotransporter barrel domain protein
RG65_RS08835	COG0307	riboflavin synthase, alpha
RG65_RS08840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RG65_RS08845	COG2814	Major facilitator Superfamily
RG65_RS08850	COG0583	DNA-binding transcription factor activity
RG65_RS08870	COG2814	Major facilitator Superfamily
RG65_RS08875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG65_RS08880	COG0791	NLP P60 protein
RG65_RS08885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RG65_RS08890	COG1201	RNA secondary structure unwinding
RG65_RS08900	COG0346	lactoylglutathione lyase activity
RG65_RS08905	COG1902	pentaerythritol trinitrate reductase activity
RG65_RS08910	COG1309	transcriptional regulator
RG65_RS08915	COG3313	Fe-S protein
RG65_RS08920	COG4989	oxidoreductase activity
RG65_RS08925	COG2032	superoxide dismutase activity
RG65_RS08930	COG1289	transmembrane transporter activity
RG65_RS08935	COG1566	PFAM secretion protein HlyD family protein
RG65_RS08950	COG3133	Outer membrane lipoprotein
RG65_RS08960	COG3895	Periplasmic Protein
RG65_RS08975	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RG65_RS08980	COG0625	glutathione transferase activity
RG65_RS08985	COG3104	oligopeptide transport
RG65_RS08995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RG65_RS09005	COG4659	FMN binding
RG65_RS09050	COG0673	inositol 2-dehydrogenase activity
RG65_RS09060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RG65_RS09065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS09065	COG1263	PTS System
RG65_RS09070	COG1609	Transcriptional regulator
RG65_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS09080	COG1309	transcriptional regulator
RG65_RS09085	COG3250	beta-galactosidase activity
RG65_RS09100	COG5339	Protein conserved in bacteria
RG65_RS09105	COG1482	cell wall glycoprotein biosynthetic process
RG65_RS09110	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG65_RS09110	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG65_RS09115	COG0114	fumarate hydratase activity
RG65_RS09125	COG2205	protein histidine kinase activity
RG65_RS09130	COG0745	RESPONSE REGULATOR receiver
RG65_RS09135	COG3136	membrane protein required for alginate biosynthesis
RG65_RS09145	COG0531	amino acid
RG65_RS09160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RG65_RS09165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RG65_RS09170	COG0628	permease
RG65_RS09185	COG3591	Belongs to the peptidase S1B family
RG65_RS09205	COG2814	Major facilitator Superfamily
RG65_RS09210	COG0583	DNA-binding transcription factor activity
RG65_RS09215	COG1940	carbohydrate kinase activity
RG65_RS09220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG65_RS09230	COG3381	protein complex oligomerization
RG65_RS09235	COG3302	dmso reductase anchor subunit
RG65_RS09240	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS09245	COG0243	molybdopterin cofactor binding
RG65_RS09250	COG0243	molybdopterin cofactor binding
RG65_RS09265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG65_RS09285	COG4948	Mandelate Racemase Muconate Lactonizing
RG65_RS09290	COG1063	alcohol dehydrogenase
RG65_RS09300	COG0582	viral genome integration into host DNA
RG65_RS09305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG65_RS09340	COG2801	Transposase and inactivated derivatives
RG65_RS09360	COG3077	Addiction module antitoxin, RelB DinJ family
RG65_RS09365	COG2026	Addiction module toxin, RelE StbE family
RG65_RS09385	COG1403	HNH endonuclease
RG65_RS09390	COG0484	heat shock protein binding
RG65_RS09395	COG1278	Cold shock
RG65_RS09400	COG1278	Cold shock
RG65_RS09415	COG3772	lysozyme
RG65_RS09425	COG1278	Cold shock
RG65_RS09445	COG5562	phage envelope protein
RG65_RS09455	COG4220	transposase activity
RG65_RS09465	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG65_RS09470	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG65_RS09475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG65_RS09485	COG0477	Major facilitator Superfamily
RG65_RS09490	COG0246	Mannitol dehydrogenase
RG65_RS09500	COG1802	Transcriptional regulator
RG65_RS09505	COG4221	oxidoreductase activity
RG65_RS09515	COG0339	signal peptide processing
RG65_RS09525	COG1546	Belongs to the CinA family
RG65_RS09530	COG3111	PFAM Bacterial OB fold (BOF) protein
RG65_RS09535	COG3706	GGDEF domain
RG65_RS09545	COG2814	Major facilitator Superfamily
RG65_RS09550	COG0697	spore germination
RG65_RS09555	COG2188	Transcriptional regulator
RG65_RS09565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RG65_RS09570	COG1447	Phosphotransferase system cellobiose-specific component IIA
RG65_RS09580	COG2723	6-phospho-beta-galactosidase activity
RG65_RS09590	COG4977	sequence-specific DNA binding
RG65_RS09595	COG1846	Transcriptional regulator
RG65_RS09625	COG0583	DNA-binding transcription factor activity
RG65_RS09630	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS09635	COG2066	Belongs to the glutaminase family
RG65_RS09645	COG2199	diguanylate cyclase activity
RG65_RS09665	COG3781	membrane
RG65_RS09715	COG2911	Protein conserved in bacteria
RG65_RS09715	COG3210	domain, Protein
RG65_RS09720	COG1396	sequence-specific DNA binding
RG65_RS09725	COG3550	peptidyl-serine autophosphorylation
RG65_RS09735	COG4977	sequence-specific DNA binding
RG65_RS09745	COG3539	Fimbrial protein
RG65_RS09755	COG3188	usher protein
RG65_RS09760	COG3539	Fimbrial protein
RG65_RS09765	COG3539	Fimbrial protein
RG65_RS09770	COG3539	Fimbrial protein
RG65_RS09775	COG0243	molybdopterin cofactor binding
RG65_RS09785	COG2207	Transcriptional regulator
RG65_RS09790	COG3119	arylsulfatase activity
RG65_RS09795	COG0641	radical SAM
RG65_RS09800	COG4178	(ABC) transporter
RG65_RS09805	COG4771	TonB-dependent receptor
RG65_RS09810	COG0612	Peptidase, M16
RG65_RS09825	COG0076	glutamate decarboxylase activity
RG65_RS09830	COG0531	amino acid
RG65_RS09835	COG1649	PFAM Uncharacterised BCR, COG1649
RG65_RS09845	COG2202	Pas domain
RG65_RS09845	COG2199	diguanylate cyclase activity
RG65_RS09845	COG2200	EAL domain
RG65_RS09850	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
RG65_RS09855	COG0747	negative chemotaxis
RG65_RS09860	COG0601	transmembrane transport
RG65_RS09865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG65_RS09870	COG0444	Belongs to the ABC transporter superfamily
RG65_RS09875	COG4608	Belongs to the ABC transporter superfamily
RG65_RS09880	COG1764	response to oxidative stress
RG65_RS09905	COG1064	alcohol dehydrogenase
RG65_RS09910	COG3093	addiction module antidote protein HigA
RG65_RS09915	COG2864	formate dehydrogenase
RG65_RS09920	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS09930	COG0697	spore germination
RG65_RS09935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG65_RS09940	COG4886	Leucine-rich repeat (LRR) protein
RG65_RS09945	COG2223	nitrite transmembrane transporter activity
RG65_RS09950	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG65_RS09955	COG1140	nitrate reductase beta subunit
RG65_RS09960	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG65_RS09965	COG2181	nitrate reductase activity
RG65_RS09970	COG0384	phenazine biosynthesis protein PhzF
RG65_RS09975	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RG65_RS09980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG65_RS10010	COG3209	COG3209 Rhs family protein
RG65_RS10020	COG0625	glutathione transferase activity
RG65_RS10025	COG1113	amino acid transport
RG65_RS10030	COG3391	amine dehydrogenase activity
RG65_RS10045	COG4772	TonB-dependent receptor
RG65_RS10050	COG1802	Transcriptional regulator
RG65_RS10055	COG2130	NADP-dependent
RG65_RS10065	COG1247	-acetyltransferase
RG65_RS10070	COG3238	Protein conserved in bacteria
RG65_RS10105	COG1177	transmembrane transport
RG65_RS10110	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG65_RS10115	COG3842	ATPase activity
RG65_RS10120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG65_RS10125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RG65_RS10130	COG1598	PFAM Uncharacterised protein family UPF0150
RG65_RS10135	COG1724	mRNA binding
RG65_RS10145	COG0826	peptidase U32
RG65_RS10150	COG1396	sequence-specific DNA binding
RG65_RS10155	COG3135	benzoate transporter
RG65_RS10160	COG0675	Transposase, IS605 OrfB family
RG65_RS10185	COG0500	methyltransferase
RG65_RS10190	COG1275	C4-dicarboxylate transporter malic acid transport protein
RG65_RS10195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG65_RS10200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG65_RS10205	COG2841	Protein conserved in bacteria
RG65_RS10225	COG5383	Protein conserved in bacteria
RG65_RS10230	COG0583	DNA-binding transcription factor activity
RG65_RS10235	COG0840	transmembrane signaling receptor activity
RG65_RS10250	COG3038	cytochrome b561
RG65_RS10255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RG65_RS10260	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS10265	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG65_RS10270	COG1643	Atp-dependent helicase
RG65_RS10280	COG2453	phosphatase
RG65_RS10280	COG0671	phosphoesterase, PA-phosphatase related
RG65_RS10285	COG2267	carboxylic ester hydrolase activity
RG65_RS10290	COG4589	Belongs to the CDS family
RG65_RS10295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RG65_RS10300	COG0667	Aldo Keto reductase
RG65_RS10305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RG65_RS10310	COG3327	negative regulation of DNA-templated transcription, initiation
RG65_RS10315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
RG65_RS10320	COG0183	Belongs to the thiolase family
RG65_RS10325	COG2050	protein possibly involved in aromatic compounds catabolism
RG65_RS10330	COG1250	3-hydroxyacyl-CoA dehydrogenase
RG65_RS10335	COG1024	Enoyl-CoA hydratase
RG65_RS10340	COG1024	Enoyl-CoA hydratase
RG65_RS10345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG65_RS10350	COG2151	metal-sulfur cluster biosynthetic enzyme
RG65_RS10355	COG3396	Phenylacetate-CoA oxygenase
RG65_RS10360	COG3460	Phenylacetate-CoA oxygenase
RG65_RS10365	COG3396	Phenylacetate-CoA oxygenase
RG65_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS10370	COG2030	dehydratase
RG65_RS10375	COG3733	amine oxidase
RG65_RS10380	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS10385	COG2207	Transcriptional regulator
RG65_RS10390	COG3784	Protein of unknown function (DUF1318)
RG65_RS10400	COG2911	Protein conserved in bacteria
RG65_RS10405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RG65_RS10410	COG3187	Heat shock protein
RG65_RS10415	COG3042	response to heat
RG65_RS10420	COG0674	pyruvate-flavodoxin oxidoreductase activity
RG65_RS10420	COG1013	pyruvate-flavodoxin oxidoreductase activity
RG65_RS10420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RG65_RS10420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RG65_RS10430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG65_RS10435	COG0589	response to stress
RG65_RS10445	COG1121	(ABC) transporter
RG65_RS10450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RG65_RS10455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RG65_RS10460	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG65_RS10465	COG5301	cellulose 1,4-beta-cellobiosidase activity
RG65_RS10470	COG1475	DNA binding
RG65_RS10480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RG65_RS10490	COG3772	lysozyme
RG65_RS10505	COG3064	Membrane
RG65_RS10590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG65_RS10595	COG3723	Recombinational DNA repair protein, rece pathway
RG65_RS10615	COG0582	viral genome integration into host DNA
RG65_RS10625	COG0513	Belongs to the DEAD box helicase family
RG65_RS10640	COG3706	GGDEF domain
RG65_RS10645	COG2840	Smr protein MutS2
RG65_RS10650	COG0583	DNA-binding transcription factor activity
RG65_RS10655	COG1473	amidohydrolase
RG65_RS10660	COG1473	amidohydrolase
RG65_RS10670	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RG65_RS10675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RG65_RS10680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG65_RS10685	COG0589	response to stress
RG65_RS10690	COG3182	Iron-regulated membrane protein
RG65_RS10695	COG0668	transmembrane transport
RG65_RS10700	COG4166	transmembrane transport
RG65_RS10705	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RG65_RS10710	COG0583	DNA-binding transcription factor activity
RG65_RS10715	COG1073	alpha beta
RG65_RS10720	COG0702	epimerase
RG65_RS10725	COG2866	Carboxypeptidase
RG65_RS10730	COG4948	Mandelate Racemase Muconate Lactonizing
RG65_RS10735	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RG65_RS10740	COG3283	Transcriptional regulator of aromatic amino acids metabolism
RG65_RS10750	COG3106	COG3106 Predicted ATPase
RG65_RS10755	COG1609	Transcriptional regulator
RG65_RS10765	COG3842	ATPase activity
RG65_RS10770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG65_RS10775	COG1554	hydrolase, family 65, central catalytic
RG65_RS10780	COG0673	inositol 2-dehydrogenase activity
RG65_RS10785	COG1082	Xylose isomerase domain protein TIM barrel
RG65_RS10790	COG1063	alcohol dehydrogenase
RG65_RS10795	COG0395	ABC-type sugar transport system, permease component
RG65_RS10800	COG1175	transmembrane transport
RG65_RS10805	COG1653	transport
RG65_RS10810	COG0366	Alpha amylase catalytic
RG65_RS10815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG65_RS10825	COG1983	PspC domain protein
RG65_RS10835	COG1842	Phage shock protein A
RG65_RS10840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RG65_RS10845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RG65_RS10850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RG65_RS10855	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS10865	COG1917	Cupin 2, conserved barrel domain protein
RG65_RS10865	COG1396	sequence-specific DNA binding
RG65_RS10870	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RG65_RS10875	COG0174	glutamine synthetase
RG65_RS10880	COG0531	amino acid
RG65_RS10895	COG4166	transmembrane transport
RG65_RS10900	COG4168	peptide transport system, permease
RG65_RS10905	COG4171	peptide transport system, permease
RG65_RS10910	COG4172	Belongs to the ABC transporter superfamily
RG65_RS10915	COG4172	Belongs to the ABC transporter superfamily
RG65_RS10920	COG2852	Protein conserved in bacteria
RG65_RS10925	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RG65_RS10930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG65_RS10930	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RG65_RS10945	COG5001	Diguanylate cyclase
RG65_RS10955	COG1349	DNA-binding transcription factor activity
RG65_RS10965	COG0023	Translation Initiation Factor
RG65_RS10975	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RG65_RS10980	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
RG65_RS10985	COG0671	phosphoesterase, PA-phosphatase related
RG65_RS10995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG65_RS11015	COG0583	DNA-binding transcription factor activity
RG65_RS11025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RG65_RS11035	COG0616	signal peptide processing
RG65_RS11045	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS11050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RG65_RS11055	COG1187	pseudouridine synthase activity
RG65_RS11060	COG0009	L-threonylcarbamoyladenylate synthase
RG65_RS11065	COG0613	PHP domain protein
RG65_RS11070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RG65_RS11075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG65_RS11075	COG0512	Glutamine amidotransferase of anthranilate synthase
RG65_RS11080	COG0134	indole-3-glycerol-phosphate synthase activity
RG65_RS11080	COG0135	phosphoribosylanthranilate isomerase activity
RG65_RS11095	COG3729	General stress protein
RG65_RS11100	COG3685	Protein conserved in bacteria
RG65_RS11105	COG3685	Protein conserved in bacteria
RG65_RS11110	COG3047	cAMP biosynthetic process
RG65_RS11130	COG1607	acyl-coa hydrolase
RG65_RS11135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RG65_RS11140	COG2350	Protein conserved in bacteria
RG65_RS11145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG65_RS11165	COG4608	Belongs to the ABC transporter superfamily
RG65_RS11170	COG0444	Belongs to the ABC transporter superfamily
RG65_RS11175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG65_RS11180	COG0601	transmembrane transport
RG65_RS11185	COG4166	transmembrane transport
RG65_RS11195	COG2095	MarC family integral membrane protein
RG65_RS11200	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS11200	COG1454	alcohol dehydrogenase
RG65_RS11205	COG1435	thymidine kinase activity
RG65_RS11215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RG65_RS11220	COG0745	RESPONSE REGULATOR receiver
RG65_RS11225	COG1752	Esterase of the alpha-beta hydrolase superfamily
RG65_RS11235	COG0788	formyltetrahydrofolate deformylase activity
RG65_RS11260	COG2181	nitrate reductase activity
RG65_RS11265	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RG65_RS11270	COG1140	nitrate reductase beta subunit
RG65_RS11275	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RG65_RS11280	COG2223	nitrite transmembrane transporter activity
RG65_RS11290	COG3850	Histidine kinase
RG65_RS11295	COG2197	response regulator
RG65_RS11300	COG4932	domain protein
RG65_RS11305	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RG65_RS11310	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RG65_RS11315	COG4572	Cation transport regulator
RG65_RS11320	COG0387	Pfam Sodium calcium exchanger
RG65_RS11355	COG2912	Transglutaminase-like superfamily
RG65_RS11360	COG3094	Invasion gene expression up-regulator, SirB
RG65_RS11365	COG2890	protein-(glutamine-N5) methyltransferase activity
RG65_RS11390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RG65_RS11395	COG0659	secondary active sulfate transmembrane transporter activity
RG65_RS11410	COG0012	GTP binding
RG65_RS11425	COG3468	outer membrane autotransporter barrel domain protein
RG65_RS11430	COG3284	Transcriptional regulator
RG65_RS11435	COG2376	Dihydroxyacetone kinase
RG65_RS11440	COG1461	Dihydroxyacetone kinase
RG65_RS11445	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RG65_RS11445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS11445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG65_RS11470	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
RG65_RS11485	COG1619	proteins homologs of microcin C7 resistance protein MccF
RG65_RS11495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG65_RS11505	COG2719	SpoVR family
RG65_RS11525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RG65_RS11530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RG65_RS11550	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG65_RS11580	COG2894	cell division
RG65_RS11640	COG2200	EAL domain
RG65_RS11665	COG2200	EAL domain
RG65_RS11670	COG2200	EAL domain
RG65_RS11675	COG0789	Transcriptional regulator
RG65_RS11680	COG5562	phage envelope protein
RG65_RS11695	COG0538	isocitrate dehydrogenase activity
RG65_RS11700	COG1187	pseudouridine synthase activity
RG65_RS11720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RG65_RS11730	COG2205	protein histidine kinase activity
RG65_RS11735	COG2850	peptidyl-arginine hydroxylation
RG65_RS11750	COG3842	ATPase activity
RG65_RS11760	COG1177	transmembrane transport
RG65_RS11765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG65_RS11775	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RG65_RS11780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RG65_RS11790	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG65_RS11795	COG1136	(ABC) transporter
RG65_RS11800	COG4591	ABC-type transport system involved in lipoprotein release permease component
RG65_RS11805	COG4763	Acyl-transferase
RG65_RS11810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RG65_RS11815	COG1388	LysM domain
RG65_RS11815	COG1376	ErfK ybiS ycfS ynhG family protein
RG65_RS11825	COG1309	transcriptional regulator
RG65_RS11830	COG3134	Outer membrane lipoprotein
RG65_RS11840	COG1252	NADH dehydrogenase
RG65_RS11860	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
RG65_RS11865	COG5633	Lipoprotein
RG65_RS11870	COG0537	adenosine 5'-monophosphoramidase activity
RG65_RS11875	COG4773	Receptor
RG65_RS11880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS11880	COG1263	PTS System
RG65_RS11885	COG0084	hydrolase, TatD family'
RG65_RS11890	COG0470	DNA polymerase III
RG65_RS11900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RG65_RS11905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG65_RS11910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RG65_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS11925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RG65_RS11945	COG1399	metal-binding, possibly nucleic acid-binding protein
RG65_RS11950	COG0424	maF-like protein
RG65_RS11955	COG0564	pseudouridine synthase activity
RG65_RS11965	COG1530	ribonuclease E activity
RG65_RS11970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RG65_RS11975	COG1256	bacterial-type flagellum assembly
RG65_RS11980	COG1705	Flagellar rod assembly protein muramidase FlgJ
RG65_RS11980	COG3951	Flagellar rod assembly protein muramidase FlgJ
RG65_RS11995	COG4786	Flagellar basal body rod
RG65_RS12000	COG4787	bacterial-type flagellum-dependent cell motility
RG65_RS12005	COG1749	Flagellar hook protein flgE
RG65_RS12010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RG65_RS12015	COG1558	bacterial-type flagellum-dependent cell motility
RG65_RS12020	COG1815	bacterial-type flagellum-dependent cell motility
RG65_RS12025	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RG65_RS12030	COG2747	anti-sigma28 factor FlgM
RG65_RS12035	COG3418	PFAM FlgN family protein
RG65_RS12040	COG0728	peptidoglycan biosynthetic process
RG65_RS12045	COG0673	inositol 2-dehydrogenase activity
RG65_RS12055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RG65_RS12065	COG2999	glutathione oxidoreductase activity
RG65_RS12105	COG3038	cytochrome b561
RG65_RS12110	COG2353	YceI-like domain
RG65_RS12120	COG1560	Kdo2-lipid A biosynthetic process
RG65_RS12140	COG5645	(Lipo)protein
RG65_RS12145	COG2943	transferase activity, transferring hexosyl groups
RG65_RS12160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG65_RS12165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG65_RS12200	COG2197	response regulator
RG65_RS12215	COG1462	curli production assembly transport component CsgG
RG65_RS12225	COG3381	protein complex oligomerization
RG65_RS12265	COG2801	Transposase and inactivated derivatives
RG65_RS12270	COG3706	GGDEF domain
RG65_RS12275	COG0457	Tetratricopeptide repeat
RG65_RS12280	COG0726	polysaccharide deacetylase
RG65_RS12280	COG1649	PFAM Uncharacterised BCR, COG1649
RG65_RS12285	COG1215	transferase activity, transferring glycosyl groups
RG65_RS12290	COG3658	cytochrome
RG65_RS12295	COG1702	phosphate starvation-inducible protein PhoH
RG65_RS12310	COG2822	iron ion transport
RG65_RS12325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG65_RS12340	COG0506	proline dehydrogenase activity
RG65_RS12340	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG65_RS12340	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG65_RS12345	COG1309	transcriptional regulator
RG65_RS12380	COG2233	PERMEase
RG65_RS12385	COG3729	General stress protein
RG65_RS12430	COG0243	molybdopterin cofactor binding
RG65_RS12435	COG3005	denitrification pathway
RG65_RS12440	COG0745	RESPONSE REGULATOR receiver
RG65_RS12445	COG1879	ABC-type sugar transport system periplasmic component
RG65_RS12450	COG2205	protein histidine kinase activity
RG65_RS12450	COG0784	Response regulator, receiver
RG65_RS12450	COG2198	Histidine kinase
RG65_RS12455	COG0348	domain, Protein
RG65_RS12475	COG1278	Cold shock
RG65_RS12480	COG1278	Cold shock
RG65_RS12500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG65_RS12505	COG1596	polysaccharide export
RG65_RS12510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RG65_RS12515	COG0489	protein tyrosine kinase activity
RG65_RS12515	COG3206	protein involved in exopolysaccharide biosynthesis
RG65_RS12530	COG1294	oxidase, subunit
RG65_RS12535	COG1271	oxidase subunit
RG65_RS12540	COG1773	rubredoxin
RG65_RS12545	COG1999	signal sequence binding
RG65_RS12550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RG65_RS12555	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RG65_RS12560	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RG65_RS12565	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RG65_RS12575	COG0670	Belongs to the BI1 family
RG65_RS12580	COG2920	part of a sulfur-relay system
RG65_RS12585	COG1254	Belongs to the acylphosphatase family
RG65_RS12600	COG1832	CoA-binding protein
RG65_RS12620	COG0210	DNA helicase
RG65_RS12625	COG3304	Inner membrane component domain
RG65_RS12630	COG1289	transmembrane transporter activity
RG65_RS12635	COG3070	regulator of competence-specific genes
RG65_RS12650	COG2885	chlorophyll binding
RG65_RS12650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG65_RS12660	COG1067	ATP-dependent peptidase activity
RG65_RS12670	COG3130	regulation of translation
RG65_RS12675	COG3009	Protein conserved in bacteria
RG65_RS12680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RG65_RS12680	COG3008	intermembrane lipid transfer
RG65_RS12685	COG2995	paraquat-inducible protein a
RG65_RS12690	COG0488	(ABC) transporter
RG65_RS12700	COG0633	Ferredoxin
RG65_RS12700	COG3217	Mosc domain protein beta barrel domain protein
RG65_RS12715	COG3121	Chaperone
RG65_RS12720	COG3539	Fimbrial protein
RG65_RS12725	COG3539	Fimbrial protein
RG65_RS12730	COG3539	Fimbrial protein
RG65_RS12735	COG3188	usher protein
RG65_RS12740	COG3121	Chaperone
RG65_RS12745	COG3539	Fimbrial protein
RG65_RS12755	COG0431	NADPH-dependent FMN reductase
RG65_RS12760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RG65_RS12770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG65_RS12785	COG0308	aminopeptidase N
RG65_RS12810	COG1448	Aminotransferase
RG65_RS12820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RG65_RS12825	COG3108	Peptidase M15
RG65_RS12835	COG2989	Protein conserved in bacteria
RG65_RS12845	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
RG65_RS12855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RG65_RS12860	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RG65_RS12865	COG3173	Aminoglycoside phosphotransferase
RG65_RS12880	COG3214	Protein conserved in bacteria
RG65_RS12890	COG1132	(ABC) transporter
RG65_RS12895	COG0658	competence protein
RG65_RS12895	COG2333	competence protein COMEC
RG65_RS12905	COG0539	negative regulation of cytoplasmic translation
RG65_RS12915	COG0501	Belongs to the peptidase M48B family
RG65_RS12930	COG2323	membrane
RG65_RS12935	COG1944	ATP diphosphatase activity
RG65_RS12940	COG2116	formate transmembrane transporter activity
RG65_RS12945	COG1882	Formate acetyltransferase
RG65_RS12950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG65_RS12955	COG2249	NAD(P)H dehydrogenase (quinone) activity
RG65_RS12960	COG0583	DNA-binding transcription factor activity
RG65_RS12965	COG0531	amino acid
RG65_RS12975	COG1335	isochorismatase
RG65_RS12980	COG3302	dmso reductase anchor subunit
RG65_RS12985	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS12990	COG0243	molybdopterin cofactor binding
RG65_RS13000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RG65_RS13015	COG1522	sequence-specific DNA binding
RG65_RS13025	COG0492	ferredoxin-NADP+ reductase activity
RG65_RS13030	COG4988	ABC transporter
RG65_RS13035	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RG65_RS13065	COG0542	response to heat
RG65_RS13075	COG1278	Cold shock
RG65_RS13085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG65_RS13090	COG2990	Protein conserved in bacteria
RG65_RS13095	COG3593	DNA synthesis involved in DNA repair
RG65_RS13115	COG2431	L-lysine efflux transmembrane transporter activity
RG65_RS13125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RG65_RS13130	COG0028	Belongs to the TPP enzyme family
RG65_RS13135	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RG65_RS13140	COG0702	epimerase
RG65_RS13145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RG65_RS13150	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG65_RS13165	COG1126	abc transporter atp-binding protein
RG65_RS13170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS13175	COG4215	(ABC) transporter
RG65_RS13180	COG4160	amino acid transport
RG65_RS13185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS13205	COG1177	transmembrane transport
RG65_RS13210	COG1176	ABC-type spermidine putrescine transport system, permease component I
RG65_RS13215	COG3842	ATPase activity
RG65_RS13220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RG65_RS13240	COG0778	Nitroreductase
RG65_RS13250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG65_RS13285	COG4695	Portal protein
RG65_RS13335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG65_RS13375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RG65_RS13380	COG3226	Transcriptional regulator
RG65_RS13385	COG0738	Major facilitator superfamily
RG65_RS13390	COG0561	phosphatase activity
RG65_RS13400	COG2814	Major facilitator Superfamily
RG65_RS13405	COG0671	phosphoesterase, PA-phosphatase related
RG65_RS13410	COG1349	DNA-binding transcription factor activity
RG65_RS13415	COG1686	Belongs to the peptidase S11 family
RG65_RS13420	COG0625	glutathione transferase activity
RG65_RS13425	COG2133	pyrroloquinoline quinone binding
RG65_RS13440	COG2199	diguanylate cyclase activity
RG65_RS13445	COG2200	EAL domain
RG65_RS13470	COG1446	asparaginase
RG65_RS13475	COG0303	'Molybdopterin
RG65_RS13480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG65_RS13485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG65_RS13490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG65_RS13495	COG1882	Formate acetyltransferase
RG65_RS13500	COG0561	phosphatase activity
RG65_RS13515	COG0488	(ABC) transporter
RG65_RS13520	COG1376	ErfK ybiS ycfS ynhG family protein
RG65_RS13525	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG65_RS13530	COG1321	iron dependent repressor
RG65_RS13540	COG2194	sulfuric ester hydrolase activity
RG65_RS13545	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RG65_RS13550	COG5006	permease, DMT superfamily
RG65_RS13575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS13580	COG0765	amino acid transport
RG65_RS13585	COG1126	abc transporter atp-binding protein
RG65_RS13595	COG0668	transmembrane transport
RG65_RS13610	COG4774	siderophore transport
RG65_RS13620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG65_RS13630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG65_RS13635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RG65_RS13640	COG1199	ATP-dependent helicase activity
RG65_RS13650	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RG65_RS13655	COG0513	Belongs to the DEAD box helicase family
RG65_RS13660	COG1309	transcriptional regulator
RG65_RS13670	COG1131	(ABC) transporter
RG65_RS13675	COG0842	Transport permease protein
RG65_RS13680	COG0842	Transport permease protein
RG65_RS13690	COG3568	Endonuclease Exonuclease Phosphatase
RG65_RS13695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RG65_RS13700	COG0392	lysyltransferase activity
RG65_RS13705	COG0670	Belongs to the BI1 family
RG65_RS13710	COG0670	Belongs to the BI1 family
RG65_RS13715	COG0314	molybdopterin synthase activity
RG65_RS13720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RG65_RS13730	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG65_RS13740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RG65_RS13750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RG65_RS13755	COG2226	methyltransferase
RG65_RS13770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RG65_RS13775	COG1881	PFAM PEBP family protein
RG65_RS13785	COG4677	pectinesterase activity
RG65_RS13790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RG65_RS13795	COG0471	metal ion transport
RG65_RS13800	COG2828	Protein conserved in bacteria
RG65_RS13805	COG0583	DNA-binding transcription factor activity
RG65_RS13815	COG0561	phosphatase activity
RG65_RS13825	COG4149	molybdate abc transporter
RG65_RS13830	COG0725	ABC transporter, periplasmic molybdate-binding protein
RG65_RS13845	COG3585	molybdate ion transport
RG65_RS13845	COG2005	Transcriptional regulator
RG65_RS13850	COG1119	ATPase activity
RG65_RS13855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RG65_RS13860	COG1085	galactose-1-phosphate uridylyltransferase
RG65_RS13870	COG2017	converts alpha-aldose to the beta-anomer
RG65_RS13880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RG65_RS13900	COG3201	nicotinamide mononucleotide transporter
RG65_RS13950	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RG65_RS13955	COG2885	chlorophyll binding
RG65_RS13965	COG3064	Membrane
RG65_RS13970	COG0848	biopolymer transport protein
RG65_RS13975	COG0811	peptide transport
RG65_RS13980	COG0824	Thioesterase
RG65_RS13985	COG3790	cyd operon protein YbgE
RG65_RS13990	COG4890	Cyd operon protein YbgT
RG65_RS13995	COG1294	oxidase, subunit
RG65_RS14000	COG1271	oxidase subunit
RG65_RS14010	COG0383	alpha-mannosidase activity
RG65_RS14015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS14015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS14015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS14020	COG2188	Transcriptional regulator
RG65_RS14025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG65_RS14035	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG65_RS14040	COG0567	Dehydrogenase, E1 component
RG65_RS14050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG65_RS14055	COG1053	succinate dehydrogenase
RG65_RS14060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RG65_RS14065	COG2009	succinate dehydrogenase
RG65_RS14085	COG0372	Belongs to the citrate synthase family
RG65_RS14090	COG3539	Fimbrial protein
RG65_RS14095	COG3188	usher protein
RG65_RS14100	COG3121	Chaperone
RG65_RS14105	COG3539	Fimbrial protein
RG65_RS14110	COG3180	Ammonia monooxygenase
RG65_RS14125	COG1984	allophanate hydrolase subunit 2
RG65_RS14130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RG65_RS14135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RG65_RS14145	COG0415	Belongs to the DNA photolyase family
RG65_RS14150	COG3272	Protein of unknown function (DUF1722)
RG65_RS14160	COG5433	transposase activity
RG65_RS14205	COG2205	protein histidine kinase activity
RG65_RS14210	COG0745	RESPONSE REGULATOR receiver
RG65_RS14225	COG1982	Orn Lys Arg decarboxylase major
RG65_RS14230	COG0531	amino acid
RG65_RS14235	COG0033	Phosphoglucomutase
RG65_RS14240	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
RG65_RS14245	COG0596	Alpha beta hydrolase
RG65_RS14255	COG0716	FMN binding
RG65_RS14270	COG0735	belongs to the Fur family
RG65_RS14295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS14295	COG1263	PTS System
RG65_RS14295	COG2190	(PTS) system
RG65_RS14305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG65_RS14310	COG1940	carbohydrate kinase activity
RG65_RS14310	COG1846	Transcriptional regulator
RG65_RS14315	COG0647	UMP catabolic process
RG65_RS14320	COG0367	asparagine synthase
RG65_RS14365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RG65_RS14375	COG1702	phosphate starvation-inducible protein PhoH
RG65_RS14385	COG4535	Mg2 and Co2 transporter CorC
RG65_RS14390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RG65_RS14405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RG65_RS14410	COG0765	amino acid transport
RG65_RS14415	COG0765	amino acid transport
RG65_RS14420	COG1126	abc transporter atp-binding protein
RG65_RS14430	COG0443	Heat shock 70 kDa protein
RG65_RS14435	COG2214	Heat shock protein DnaJ domain protein
RG65_RS14445	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG65_RS14450	COG2214	Heat shock protein DnaJ domain protein
RG65_RS14460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG65_RS14465	COG2888	peptidyl-tyrosine sulfation
RG65_RS14480	COG1466	dna polymerase III delta subunit
RG65_RS14490	COG0406	alpha-ribazole phosphatase activity
RG65_RS14495	COG0799	negative regulation of ribosome biogenesis
RG65_RS14505	COG0768	penicillin binding
RG65_RS14510	COG0772	Belongs to the SEDS family
RG65_RS14515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG65_RS14520	COG1686	Belongs to the peptidase S11 family
RG65_RS14540	COG0583	DNA-binding transcription factor activity
RG65_RS14555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG65_RS14560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG65_RS14585	COG3069	C4-dicarboxylate transmembrane transporter activity
RG65_RS14590	COG4565	transcriptional regulatory protein
RG65_RS14595	COG3290	protein histidine kinase activity
RG65_RS14600	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RG65_RS14610	COG2301	Belongs to the HpcH HpaI aldolase family
RG65_RS14615	COG3051	citrate lyase alpha subunit
RG65_RS14630	COG0471	metal ion transport
RG65_RS14635	COG3719	Belongs to the RNase T2 family
RG65_RS14645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG65_RS14655	COG1063	alcohol dehydrogenase
RG65_RS14660	COG0589	response to stress
RG65_RS14665	COG3634	alkyl hydroperoxide reductase activity
RG65_RS14670	COG0450	alkyl hydroperoxide reductase
RG65_RS14675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG65_RS14680	COG0583	DNA-binding transcription factor activity
RG65_RS14685	COG3969	phosphoadenosine phosphosulfate
RG65_RS14690	COG1475	DNA binding
RG65_RS14695	COG0436	Aminotransferase
RG65_RS14700	COG0371	Dehydrogenase
RG65_RS14705	COG2879	small protein
RG65_RS14710	COG1966	Carbon starvation protein
RG65_RS14715	COG2050	protein possibly involved in aromatic compounds catabolism
RG65_RS14720	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS14725	COG1535	isochorismatase
RG65_RS14725	COG3433	isochorismatase activity
RG65_RS14730	COG1021	2,3-dihydroxybenzoate-AMP ligase
RG65_RS14735	COG1169	isochorismate synthase
RG65_RS14745	COG4592	Periplasmic binding protein
RG65_RS14755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG65_RS14760	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG65_RS14765	COG1120	ATPase activity
RG65_RS14770	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG65_RS14775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RG65_RS14775	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RG65_RS14780	COG3251	PFAM MbtH domain protein
RG65_RS14785	COG2382	esterase
RG65_RS14795	COG4771	TonB-dependent receptor
RG65_RS14800	COG2977	Belongs to the P-Pant transferase superfamily
RG65_RS14840	COG2315	Protein conserved in bacteria
RG65_RS14845	COG0778	Nitroreductase
RG65_RS14850	COG0668	transmembrane transport
RG65_RS14855	COG1113	amino acid transport
RG65_RS14860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG65_RS14865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG65_RS14870	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG65_RS14875	COG1538	Outer membrane efflux protein
RG65_RS14885	COG0745	RESPONSE REGULATOR receiver
RG65_RS14890	COG5002	protein histidine kinase activity
RG65_RS14900	COG3501	Rhs element vgr protein
RG65_RS14910	COG4104	PAAR repeat-containing protein
RG65_RS14910	COG3209	COG3209 Rhs family protein
RG65_RS14915	COG5433	transposase activity
RG65_RS14920	COG1215	transferase activity, transferring glycosyl groups
RG65_RS14925	COG4783	chaperone-mediated protein folding
RG65_RS14940	COG2207	Transcriptional regulator
RG65_RS14950	COG4571	Outer membrane protease
RG65_RS14975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RG65_RS14990	COG5562	phage envelope protein
RG65_RS15010	COG3772	lysozyme
RG65_RS15075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG65_RS15085	COG2076	Multidrug Resistance protein
RG65_RS15100	COG0582	viral genome integration into host DNA
RG65_RS15110	COG2197	response regulator
RG65_RS15115	COG3539	Fimbrial protein
RG65_RS15120	COG3539	Fimbrial protein
RG65_RS15125	COG3188	usher protein
RG65_RS15130	COG3121	Chaperone
RG65_RS15135	COG3539	Fimbrial protein
RG65_RS15145	COG2501	S4 domain
RG65_RS15150	COG1988	membrane-bound metal-dependent
RG65_RS15160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG65_RS15175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RG65_RS15180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RG65_RS15185	COG0549	Belongs to the carbamate kinase family
RG65_RS15200	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RG65_RS15205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RG65_RS15210	COG3257	ureidoglycine aminohydrolase activity
RG65_RS15215	COG1929	Belongs to the glycerate kinase type-1 family
RG65_RS15220	COG2233	PERMEase
RG65_RS15230	COG1953	Uracil, thiamine, allantoin
RG65_RS15235	COG2084	Dehydrogenase
RG65_RS15240	COG3622	Belongs to the hyi family
RG65_RS15245	COG3960	tartronate-semialdehyde synthase activity
RG65_RS15250	COG1414	Transcriptional regulator
RG65_RS15260	COG0583	DNA-binding transcription factor activity
RG65_RS15270	COG2801	Transposase and inactivated derivatives
RG65_RS15285	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RG65_RS15290	COG4181	ATPase activity
RG65_RS15295	COG2755	lipolytic protein G-D-S-L family
RG65_RS15300	COG0300	oxidoreductase activity
RG65_RS15305	COG3118	belongs to the thioredoxin family
RG65_RS15310	COG0390	transport system, permease component
RG65_RS15315	COG4619	ABC transporter
RG65_RS15320	COG0330	HflC and HflK could
RG65_RS15325	COG1585	Membrane protein implicated in regulation of membrane protease activity
RG65_RS15330	COG0789	Transcriptional regulator
RG65_RS15340	COG0531	amino acid
RG65_RS15345	COG2066	Belongs to the glutaminase family
RG65_RS15350	COG2217	Heavy metal translocating P-type atpase
RG65_RS15355	COG3093	addiction module antidote protein HigA
RG65_RS15360	COG3735	TraB family
RG65_RS15365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RG65_RS15370	COG0737	Belongs to the 5'-nucleotidase family
RG65_RS15380	COG2223	nitrite transmembrane transporter activity
RG65_RS15385	COG4651	solute:proton antiporter activity
RG65_RS15385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RG65_RS15390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG65_RS15425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RG65_RS15440	COG2832	Protein of unknown function (DUF454)
RG65_RS15445	COG3923	Primosomal replication protein n
RG65_RS15460	COG1196	nuclear chromosome segregation
RG65_RS15460	COG3264	Mechanosensitive ion channel
RG65_RS15470	COG1309	transcriptional regulator
RG65_RS15475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG65_RS15480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG65_RS15495	COG0110	maltose O-acetyltransferase activity
RG65_RS15505	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG65_RS15510	COG5507	3-demethylubiquinone-9 3-methyltransferase
RG65_RS15520	COG3695	enzyme binding
RG65_RS15525	COG3126	Type III secretion system lipoprotein chaperone (YscW)
RG65_RS15530	COG1946	Acyl-CoA thioesterase
RG65_RS15535	COG0004	ammonium transporteR
RG65_RS15540	COG0347	Belongs to the P(II) protein family
RG65_RS15545	COG1132	(ABC) transporter
RG65_RS15550	COG1132	(ABC) transporter
RG65_RS15555	COG1522	sequence-specific DNA binding
RG65_RS15565	COG4533	DNA binding
RG65_RS15575	COG0824	Thioesterase
RG65_RS15580	COG1555	photosystem II stabilization
RG65_RS15585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG65_RS15590	COG0776	regulation of translation
RG65_RS15595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RG65_RS15620	COG0271	Belongs to the BolA IbaG family
RG65_RS15625	COG3056	Lipoprotein
RG65_RS15630	COG2223	nitrite transmembrane transporter activity
RG65_RS15635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RG65_RS15640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RG65_RS15645	COG1845	cytochrome c oxidase, subunit III
RG65_RS15650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RG65_RS15675	COG2814	Major facilitator Superfamily
RG65_RS15685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RG65_RS15690	COG0693	protein deglycase activity
RG65_RS15705	COG0142	geranyltranstransferase activity
RG65_RS15715	COG0667	Aldo Keto reductase
RG65_RS15720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RG65_RS15725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RG65_RS15740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG65_RS15740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RG65_RS15750	COG4238	major outer membrane lipoprotein
RG65_RS15755	COG3248	Nucleoside-binding outer membrane protein
RG65_RS15760	COG1403	HNH endonuclease
RG65_RS15765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG65_RS15770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RG65_RS15775	COG1862	Preprotein translocase
RG65_RS15795	COG0366	Alpha amylase catalytic
RG65_RS15800	COG1113	amino acid transport
RG65_RS15805	COG1114	Component of the transport system for branched-chain amino acids
RG65_RS15810	COG5002	protein histidine kinase activity
RG65_RS15815	COG0745	RESPONSE REGULATOR receiver
RG65_RS15820	COG0420	3'-5' exonuclease activity
RG65_RS15825	COG0419	ATPase involved in DNA repair
RG65_RS15830	COG2814	Major facilitator Superfamily
RG65_RS15835	COG1940	carbohydrate kinase activity
RG65_RS15855	COG4126	flavin adenine dinucleotide binding
RG65_RS15880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RG65_RS15885	COG3706	GGDEF domain
RG65_RS15895	COG1785	Belongs to the alkaline phosphatase family
RG65_RS15910	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG65_RS15930	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RG65_RS15940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG65_RS15945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG65_RS15950	COG3468	outer membrane autotransporter barrel domain protein
RG65_RS15960	COG0113	porphobilinogen synthase activity
RG65_RS15965	COG2175	clavaminate synthase activity
RG65_RS15970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RG65_RS15975	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
RG65_RS15980	COG4521	taurine ABC transporter
RG65_RS15990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RG65_RS15995	COG1215	transferase activity, transferring glycosyl groups
RG65_RS16025	COG3122	Protein conserved in bacteria
RG65_RS16030	COG2814	Major facilitator Superfamily
RG65_RS16075	COG1414	Transcriptional regulator
RG65_RS16080	COG1609	Transcriptional regulator
RG65_RS16095	COG2223	nitrite transmembrane transporter activity
RG65_RS16100	COG0110	maltose O-acetyltransferase activity
RG65_RS16110	COG2807	transmembrane transport
RG65_RS16120	COG0288	reversible hydration of carbon dioxide
RG65_RS16125	COG0583	DNA-binding transcription factor activity
RG65_RS16130	COG0402	S-adenosylhomocysteine deaminase activity
RG65_RS16135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RG65_RS16145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG65_RS16150	COG2079	MmgE PrpD family protein
RG65_RS16155	COG0372	Belongs to the citrate synthase family
RG65_RS16160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RG65_RS16165	COG3829	transcription factor binding
RG65_RS16175	COG1280	lysine exporter protein (LysE YggA)
RG65_RS16190	COG1064	alcohol dehydrogenase
RG65_RS16200	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG65_RS16205	COG1129	ABC transporter
RG65_RS16210	COG1879	ABC-type sugar transport system periplasmic component
RG65_RS16220	COG0402	S-adenosylhomocysteine deaminase activity
RG65_RS16225	COG0549	Belongs to the carbamate kinase family
RG65_RS16235	COG1304	FMN binding
RG65_RS16240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RG65_RS16250	COG0666	response to abiotic stimulus
RG65_RS16265	COG0583	DNA-binding transcription factor activity
RG65_RS16270	COG2771	luxR family
RG65_RS16270	COG2200	EAL domain
RG65_RS16280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RG65_RS16320	COG1556	Lactate utilization protein
RG65_RS16325	COG1139	Iron-sulfur cluster binding protein
RG65_RS16330	COG0247	lactate metabolic process
RG65_RS16335	COG2207	Transcriptional regulator
RG65_RS16340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG65_RS16350	COG3059	membrane
RG65_RS16355	COG0656	L-ascorbic acid biosynthetic process
RG65_RS16360	COG3708	Transcriptional regulator
RG65_RS16360	COG2207	Transcriptional regulator
RG65_RS16365	COG1388	LysM domain
RG65_RS16415	COG3188	usher protein
RG65_RS16425	COG3121	Chaperone
RG65_RS16430	COG0727	PFAM Uncharacterised protein family (UPF0153)
RG65_RS16450	COG2080	2 iron, 2 sulfur cluster binding
RG65_RS16455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RG65_RS16460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RG65_RS16465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RG65_RS16470	COG0583	DNA-binding transcription factor activity
RG65_RS16490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RG65_RS16515	COG3778	Protein conserved in bacteria
RG65_RS16520	COG3299	homolog of phage Mu protein gp47
RG65_RS16535	COG5532	Uncharacterized conserved protein (DUF2303)
RG65_RS16540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RG65_RS16560	COG0582	viral genome integration into host DNA
RG65_RS16580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RG65_RS16600	COG2195	Cleaves the N-terminal amino acid of tripeptides
RG65_RS16605	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RG65_RS16610	COG1690	Belongs to the RtcB family
RG65_RS16620	COG0454	-acetyltransferase
RG65_RS16625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RG65_RS16650	COG0791	NLP P60 protein
RG65_RS16655	COG3077	Addiction module antitoxin, RelB DinJ family
RG65_RS16660	COG3041	Addiction module toxin RelE StbE family
RG65_RS16665	COG3034	peptidoglycan biosynthetic process
RG65_RS16670	COG0121	glutamine amidotransferase
RG65_RS16680	COG1960	acyl-CoA dehydrogenase activity
RG65_RS16690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RG65_RS16705	COG5433	transposase activity
RG65_RS16710	COG5433	transposase activity
RG65_RS16720	COG3209	COG3209 Rhs family protein
RG65_RS16745	COG3157	Type VI secretion system effector, Hcp
RG65_RS16750	COG4104	PAAR repeat-containing protein
RG65_RS16770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RG65_RS16780	COG2226	methyltransferase
RG65_RS16790	COG0741	lytic transglycosylase activity
RG65_RS16790	COG1388	LysM domain
RG65_RS16795	COG2226	methyltransferase
RG65_RS16805	COG0583	DNA-binding transcription factor activity
RG65_RS16810	COG0656	L-ascorbic acid biosynthetic process
RG65_RS16845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RG65_RS16850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RG65_RS16855	COG2011	ABC-type metal ion transport system permease component
RG65_RS16860	COG1464	Belongs to the NlpA lipoprotein family
RG65_RS16870	COG1720	tRNA m6t6A37 methyltransferase activity
RG65_RS16885	COG3015	lipoprotein NlpE involved in copper resistance
RG65_RS16890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RG65_RS16895	COG4681	YaeQ
RG65_RS16905	COG4568	rho-dependent transcription termination
RG65_RS16910	COG0037	tRNA processing
RG65_RS16915	COG0346	lactoylglutathione lyase activity
RG65_RS16920	COG1982	Orn Lys Arg decarboxylase major
RG65_RS16930	COG0587	DNA-directed DNA polymerase activity
RG65_RS16955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RG65_RS16960	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RG65_RS16970	COG0750	zinc metalloprotease
RG65_RS16975	COG0575	Belongs to the CDS family
RG65_RS16980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RG65_RS16985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RG65_RS17020	COG0024	Methionine aminopeptidase
RG65_RS17040	COG3835	regulator
RG65_RS17045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RG65_RS17065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG65_RS17070	COG2860	membrane
RG65_RS17090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RG65_RS17095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RG65_RS17100	COG1120	ATPase activity
RG65_RS17105	COG4774	siderophore transport
RG65_RS17110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RG65_RS17120	COG1643	Atp-dependent helicase
RG65_RS17125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RG65_RS17135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RG65_RS17145	COG0617	tRNA 3'-terminal CCA addition
RG65_RS17150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RG65_RS17155	COG3539	Fimbrial protein
RG65_RS17160	COG3121	Chaperone
RG65_RS17165	COG3188	usher protein
RG65_RS17170	COG3539	Fimbrial protein
RG65_RS17175	COG3539	Fimbrial protein
RG65_RS17180	COG3539	Fimbrial protein
RG65_RS17185	COG3539	Fimbrial protein
RG65_RS17200	COG5464	transposase or invertase
RG65_RS17220	COG0726	polysaccharide deacetylase
RG65_RS17225	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS17230	COG0842	Transport permease protein
RG65_RS17235	COG1131	(ABC) transporter
RG65_RS17240	COG0288	reversible hydration of carbon dioxide
RG65_RS17245	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RG65_RS17250	COG4993	Dehydrogenase
RG65_RS17260	COG2132	Multicopper oxidase
RG65_RS17285	COG1049	propionate catabolic process, 2-methylcitrate cycle
RG65_RS17295	COG3064	Membrane
RG65_RS17300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG65_RS17305	COG0508	dehydrogenase complex catalyzes the overall conversion of
RG65_RS17310	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RG65_RS17320	COG2186	Transcriptional regulator
RG65_RS17325	COG1113	amino acid transport
RG65_RS17330	COG3725	Membrane protein required for beta-lactamase induction
RG65_RS17335	COG3023	N-Acetylmuramoyl-L-alanine amidase
RG65_RS17340	COG0157	Belongs to the NadC ModD family
RG65_RS17350	COG4969	Belongs to the N-Me-Phe pilin family
RG65_RS17355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RG65_RS17360	COG1459	type II secretion system
RG65_RS17370	COG0237	dephospho-CoA kinase activity
RG65_RS17390	COG0494	nUDIX hydrolase
RG65_RS17410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RG65_RS17415	COG0849	cell division
RG65_RS17420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RG65_RS17425	COG1181	Belongs to the D-alanine--D-alanine ligase family
RG65_RS17440	COG0772	Belongs to the SEDS family
RG65_RS17455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RG65_RS17460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RG65_RS17465	COG0768	penicillin binding
RG65_RS17470	COG3116	cell division
RG65_RS17490	COG1609	Transcriptional regulator
RG65_RS17500	COG0440	acetolactate synthase activity
RG65_RS17505	COG0028	Belongs to the TPP enzyme family
RG65_RS17510	COG0583	DNA-binding transcription factor activity
RG65_RS17525	COG0473	3-isopropylmalate dehydrogenase activity
RG65_RS17540	COG2814	Major facilitator Superfamily
RG65_RS17555	COG4143	(ABC) transporter
RG65_RS17560	COG1178	ABC-type Fe3 transport system permease component
RG65_RS17570	COG0586	Pfam SNARE associated Golgi protein
RG65_RS17575	COG4977	sequence-specific DNA binding
RG65_RS17595	COG0235	Class ii aldolase
RG65_RS17600	COG0417	DNA replication proofreading
RG65_RS17610	COG0564	pseudouridine synthase activity
RG65_RS17615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RG65_RS17620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG65_RS17625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG65_RS17665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RG65_RS17680	COG2271	Major facilitator Superfamily
RG65_RS17685	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RG65_RS17690	COG0644	oxidoreductase
RG65_RS17745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RG65_RS17750	COG0505	Belongs to the CarA family
RG65_RS17770	COG1047	Peptidyl-prolyl cis-trans
RG65_RS17785	COG0196	riboflavin kinase activity
RG65_RS17810	COG3188	usher protein
RG65_RS17825	COG0583	DNA-binding transcription factor activity
RG65_RS17855	COG4735	regulation of single-species biofilm formation
RG65_RS17860	COG1584	GPR1 FUN34 yaaH family protein
RG65_RS17865	COG0521	Mo-molybdopterin cofactor biosynthetic process
RG65_RS17870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG65_RS17875	COG1115	amino acid carrier protein
RG65_RS17900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RG65_RS17910	COG0527	aspartate kinase activity
RG65_RS17910	COG0460	homoserine dehydrogenase
RG65_RS17920	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RG65_RS17930	COG0745	RESPONSE REGULATOR receiver
RG65_RS17935	COG4452	Inner membrane protein CreD
RG65_RS17940	COG2205	protein histidine kinase activity
RG65_RS17945	COG0745	RESPONSE REGULATOR receiver
RG65_RS17950	COG3045	CreA protein
RG65_RS17955	COG3708	Transcriptional regulator
RG65_RS17955	COG2207	Transcriptional regulator
RG65_RS17975	COG0741	lytic transglycosylase activity
RG65_RS17985	COG0488	(ABC) transporter
RG65_RS17995	COG1056	cytidyltransferase-related domain
RG65_RS17995	COG3172	ATPase kinase involved in NAD metabolism
RG65_RS18000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RG65_RS18005	COG0560	Phosphoserine phosphatase
RG65_RS18010	COG3726	membrane protein affecting hemolysin expression
RG65_RS18050	COG1328	CTP reductase activity
RG65_RS18055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG65_RS18060	COG0084	hydrolase, TatD family'
RG65_RS18065	COG4667	esterase of the alpha-beta hydrolase superfamily
RG65_RS18075	COG2823	Periplasmic or secreted lipoprotein
RG65_RS18095	COG2030	dehydratase
RG65_RS18115	COG3778	Protein conserved in bacteria
RG65_RS18160	COG1802	Transcriptional regulator
RG65_RS18160	COG4626	Terminase
RG65_RS18185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RG65_RS18195	COG1011	Hydrolase
RG65_RS18200	COG0456	acetyltransferase
RG65_RS18205	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
RG65_RS18240	COG4114	ferric iron reductase
RG65_RS18245	COG2197	response regulator
RG65_RS18250	COG2197	response regulator
RG65_RS18255	COG2966	Psort location CytoplasmicMembrane, score
RG65_RS18270	COG1484	DNA-dependent DNA replication
RG65_RS18285	COG1063	alcohol dehydrogenase
RG65_RS18290	COG1802	Transcriptional regulator
RG65_RS18295	COG2271	Major facilitator Superfamily
RG65_RS18300	COG0840	transmembrane signaling receptor activity
RG65_RS18305	COG1846	Transcriptional regulator
RG65_RS18310	COG0179	Fumarylacetoacetate (FAA) hydrolase
RG65_RS18315	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS18320	COG3384	dioxygenase
RG65_RS18330	COG3971	2-oxopent-4-enoate hydratase activity
RG65_RS18350	COG2368	4-hydroxyphenylacetate
RG65_RS18355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RG65_RS18360	COG1966	Carbon starvation protein
RG65_RS18365	COG2879	small protein
RG65_RS18370	COG0523	cobalamin synthesis protein
RG65_RS18380	COG5457	Domain of unknown function (DUF1127)
RG65_RS18400	COG2814	Major facilitator Superfamily
RG65_RS18405	COG2733	membrane
RG65_RS18410	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
RG65_RS18415	COG1924	4 iron, 4 sulfur cluster binding
RG65_RS18430	COG0477	Major facilitator Superfamily
RG65_RS18445	COG3366	ferrous iron transmembrane transporter activity
RG65_RS18450	COG0700	Nucleoside recognition
RG65_RS18455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RG65_RS18460	COG0583	DNA-binding transcription factor activity
RG65_RS18480	COG2186	Transcriptional regulator
RG65_RS18490	COG0246	Mannitol dehydrogenase
RG65_RS18505	COG2610	gluconate transmembrane transporter activity
RG65_RS18515	COG3539	Fimbrial protein
RG65_RS18520	COG3539	Fimbrial protein
RG65_RS18525	COG3539	Fimbrial protein
RG65_RS18530	COG3188	usher protein
RG65_RS18535	COG3121	Chaperone
RG65_RS18540	COG3539	Fimbrial protein
RG65_RS18545	COG3539	Fimbrial protein
RG65_RS18555	COG4974	Belongs to the 'phage' integrase family
RG65_RS18560	COG0582	viral genome integration into host DNA
RG65_RS18570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RG65_RS18575	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
RG65_RS18600	COG1401	restriction endodeoxyribonuclease activity
RG65_RS18605	COG2801	Transposase and inactivated derivatives
RG65_RS18645	COG0582	viral genome integration into host DNA
RG65_RS18655	COG1064	alcohol dehydrogenase
RG65_RS18660	COG0433	COG0433 Predicted ATPase
RG65_RS18665	COG0795	lipopolysaccharide-transporting ATPase activity
RG65_RS18670	COG0795	lipopolysaccharide-transporting ATPase activity
RG65_RS18680	COG2927	DNA polymerase III (CHI subunit)
RG65_RS18685	COG0525	valine-tRNA ligase activity
RG65_RS18690	COG4269	membrane
RG65_RS18695	COG0456	acetyltransferase
RG65_RS18700	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
RG65_RS18715	COG2731	YhcH YjgK YiaL family protein
RG65_RS18720	COG1309	transcriptional regulator
RG65_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
RG65_RS18730	COG0251	oxidation-reduction process
RG65_RS18755	COG0251	oxidation-reduction process
RG65_RS18765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RG65_RS18770	COG1609	Transcriptional regulator
RG65_RS18775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS18775	COG1263	PTS System
RG65_RS18780	COG0366	Alpha amylase catalytic
RG65_RS18790	COG1328	CTP reductase activity
RG65_RS18800	COG0602	queuosine metabolic process
RG65_RS18805	COG3783	Cytochrome b(562)
RG65_RS18810	COG0312	modulator of DNA gyrase
RG65_RS18820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RG65_RS18830	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG65_RS18835	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG65_RS18840	COG1129	ABC transporter
RG65_RS18850	COG1879	ABC-type sugar transport system periplasmic component
RG65_RS18855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RG65_RS18860	COG2337	Toxic component of a toxin-antitoxin (TA) module
RG65_RS18865	COG2336	PFAM SpoVT AbrB
RG65_RS18870	COG2105	PFAM AIG2 family protein
RG65_RS18875	COG2911	Protein conserved in bacteria
RG65_RS18880	COG0729	surface antigen
RG65_RS18895	COG1253	flavin adenine dinucleotide binding
RG65_RS18905	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RG65_RS18910	COG1218	3'(2'),5'-bisphosphate nucleotidase
RG65_RS18915	COG0737	Belongs to the 5'-nucleotidase family
RG65_RS18920	COG1733	regulation of RNA biosynthetic process
RG65_RS18925	COG0702	epimerase
RG65_RS18930	COG0697	spore germination
RG65_RS18940	COG1113	amino acid transport
RG65_RS18945	COG0545	Peptidyl-prolyl cis-trans isomerase
RG65_RS18955	COG3061	Opacity-associated protein A
RG65_RS18960	COG1309	transcriptional regulator
RG65_RS18985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RG65_RS19025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS19030	COG3414	Phosphotransferase system galactitol-specific IIB component
RG65_RS19035	COG3037	sugar-specific permease SgaT UlaA
RG65_RS19050	COG1073	alpha beta
RG65_RS19055	COG3650	response to hydrogen peroxide
RG65_RS19070	COG1960	acyl-CoA dehydrogenase activity
RG65_RS19075	COG0754	glutathionylspermidine amidase activity
RG65_RS19080	COG5463	Belongs to the UPF0441 family
RG65_RS19085	COG3766	membrane
RG65_RS19095	COG1842	Phage shock protein A
RG65_RS19100	COG3789	protein conserved in bacteria
RG65_RS19105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG65_RS19110	COG0557	exoribonuclease II activity
RG65_RS19125	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
RG65_RS19130	COG0330	HflC and HflK could
RG65_RS19135	COG0330	HflC and HflK could
RG65_RS19140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RG65_RS19160	COG0860	N-Acetylmuramoyl-L-alanine amidase
RG65_RS19165	COG0802	atpase or kinase
RG65_RS19170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RG65_RS19170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RG65_RS19175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RG65_RS19210	COG1511	domain protein
RG65_RS19210	COG3264	Mechanosensitive ion channel
RG65_RS19225	COG0531	amino acid
RG65_RS19235	COG1053	succinate dehydrogenase
RG65_RS19240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RG65_RS19255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RG65_RS19260	COG3040	lipid binding
RG65_RS19265	COG2076	Multidrug Resistance protein
RG65_RS19270	COG5510	response to toxic substance
RG65_RS19275	COG5510	response to toxic substance
RG65_RS19285	COG1509	lysine 2,3-aminomutase activity
RG65_RS19315	COG0531	amino acid
RG65_RS19320	COG3030	protein affecting phage T7 exclusion by the F plasmid
RG65_RS19330	COG1027	Aspartate ammonia-lyase
RG65_RS19335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG65_RS19350	COG1309	transcriptional regulator
RG65_RS19365	COG3710	Transcriptional regulator
RG65_RS19370	COG0531	amino acid
RG65_RS19375	COG1982	Orn Lys Arg decarboxylase major
RG65_RS19380	COG3104	oligopeptide transport
RG65_RS19385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RG65_RS19405	COG2388	GCN5-related N-acetyl-transferase
RG65_RS19410	COG3592	Divergent 4Fe-4S mono-cluster
RG65_RS19415	COG3290	protein histidine kinase activity
RG65_RS19420	COG4565	transcriptional regulatory protein
RG65_RS19430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RG65_RS19435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RG65_RS19435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RG65_RS19440	COG3647	Membrane
RG65_RS19445	COG2211	Major facilitator Superfamily
RG65_RS19450	COG1486	melibiose metabolic process
RG65_RS19460	COG2169	Transcriptional regulator
RG65_RS19465	COG1982	Orn Lys Arg decarboxylase major
RG65_RS19470	COG2207	Transcriptional regulator
RG65_RS19475	COG0531	amino acid
RG65_RS19480	COG2194	sulfuric ester hydrolase activity
RG65_RS19485	COG0745	RESPONSE REGULATOR receiver
RG65_RS19490	COG0642	Histidine kinase
RG65_RS19500	COG0477	Major facilitator Superfamily
RG65_RS19520	COG2824	Alkylphosphonate utilization operon protein PhnA
RG65_RS19525	COG2764	glyoxalase bleomycin resistance protein dioxygenase
RG65_RS19535	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RG65_RS19540	COG3639	organic phosphonate transmembrane transporter activity
RG65_RS19545	COG2188	Transcriptional regulator
RG65_RS19550	COG3624	Phosphonate C-P lyase system protein PhnG
RG65_RS19555	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RG65_RS19560	COG3626	phosphonate metabolism
RG65_RS19565	COG3627	carbon phosphorus lyase activity
RG65_RS19570	COG4107	phosphonate C-P lyase system protein PhnK
RG65_RS19580	COG4778	phosphonate C-P lyase system protein PhnL
RG65_RS19585	COG3454	Phosphonate metabolism
RG65_RS19590	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RG65_RS19595	COG0456	acetyltransferase
RG65_RS19600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RG65_RS19610	COG0698	ribose 5-phosphate isomerase
RG65_RS19615	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RG65_RS19625	COG1566	PFAM secretion protein HlyD family protein
RG65_RS19630	COG1289	transmembrane transporter activity
RG65_RS19640	COG3383	formate dehydrogenase (NAD+) activity
RG65_RS19645	COG3383	formate dehydrogenase (NAD+) activity
RG65_RS19650	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG65_RS19655	COG1301	dicarboxylic acid transport
RG65_RS19665	COG4235	cytochrome complex assembly
RG65_RS19670	COG3088	subunit of a heme lyase
RG65_RS19675	COG1138	Cytochrome C-type biogenesis protein
RG65_RS19680	COG3301	Polysulphide reductase, NrfD
RG65_RS19685	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS19690	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RG65_RS19705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RG65_RS19710	COG3162	membrane
RG65_RS19720	COG1357	PFAM Pentapeptide repeats (8 copies)
RG65_RS19725	COG0025	NhaP-type Na H and K H
RG65_RS19730	COG2252	PERMEase
RG65_RS19750	COG0789	Transcriptional regulator
RG65_RS19755	COG2207	Transcriptional regulator
RG65_RS19760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RG65_RS19775	COG0629	single-stranded DNA binding
RG65_RS19780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RG65_RS19785	COG2315	Protein conserved in bacteria
RG65_RS19790	COG0432	Pfam Uncharacterised protein family UPF0047
RG65_RS19795	COG3700	Belongs to the class B bacterial acid phosphatase family
RG65_RS19805	COG1448	Aminotransferase
RG65_RS19810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RG65_RS19815	COG0305	Participates in initiation and elongation during chromosome replication
RG65_RS19820	COG0604	alcohol dehydrogenase
RG65_RS19830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RG65_RS19845	COG0735	belongs to the Fur family
RG65_RS19850	COG3237	CsbD-like
RG65_RS19855	COG0534	Mate efflux family protein
RG65_RS19865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RG65_RS19895	COG1357	PFAM Pentapeptide repeats (8 copies)
RG65_RS19915	COG3842	ATPase activity
RG65_RS19925	COG2182	Extracellular solute-binding protein
RG65_RS19930	COG1175	transmembrane transport
RG65_RS19935	COG3833	ABC-type maltose transport systems, permease component
RG65_RS19940	COG2814	Major facilitator Superfamily
RG65_RS19940	COG0477	Major facilitator Superfamily
RG65_RS19955	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RG65_RS19985	COG0527	aspartate kinase activity
RG65_RS19990	COG0542	response to heat
RG65_RS19995	COG3541	Predicted nucleotidyltransferase
RG65_RS20010	COG1187	pseudouridine synthase activity
RG65_RS20020	COG1283	sodium-dependent phosphate transmembrane transporter activity
RG65_RS20025	COG0646	methionine synthase
RG65_RS20025	COG1410	methionine synthase
RG65_RS20030	COG1414	Transcriptional regulator
RG65_RS20050	COG2224	Isocitrate lyase
RG65_RS20055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RG65_RS20065	COG0456	acetyltransferase
RG65_RS20105	COG0151	Belongs to the GarS family
RG65_RS20110	COG2204	response regulator
RG65_RS20115	COG4191	Histidine kinase
RG65_RS20125	COG3678	ATP-independent chaperone mediated protein folding
RG65_RS20140	COG3068	Protein conserved in bacteria
RG65_RS20175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RG65_RS20180	COG2104	thiamine diphosphate biosynthetic process
RG65_RS20190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RG65_RS20235	COG0250	Participates in transcription elongation, termination and antitermination
RG65_RS20240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RG65_RS20285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RG65_RS20285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RG65_RS20340	COG1309	transcriptional regulator
RG65_RS20355	COG0583	DNA-binding transcription factor activity
RG65_RS20370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RG65_RS20385	COG2194	sulfuric ester hydrolase activity
RG65_RS20395	COG2207	Transcriptional regulator
RG65_RS20400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS20405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RG65_RS20410	COG1882	Formate acetyltransferase
RG65_RS20415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS20420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS20425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RG65_RS20425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS20425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS20430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RG65_RS20435	COG0371	Dehydrogenase
RG65_RS20445	COG3738	Protein conserved in bacteria
RG65_RS20450	COG0697	spore germination
RG65_RS20460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RG65_RS20470	COG0527	aspartate kinase activity
RG65_RS20470	COG0460	homoserine dehydrogenase
RG65_RS20475	COG0626	cystathionine gamma-synthase activity
RG65_RS20485	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
RG65_RS20490	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
RG65_RS20530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RG65_RS20535	COG1609	Transcriptional regulator
RG65_RS20540	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RG65_RS20555	COG1575	Belongs to the MenA family. Type 1 subfamily
RG65_RS20570	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RG65_RS20580	COG1494	fructose-1,6-bisphosphatase
RG65_RS20590	COG0589	response to stress
RG65_RS20595	COG3691	Protein conserved in bacteria
RG65_RS20600	COG3152	Membrane
RG65_RS20625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RG65_RS20650	COG3678	ATP-independent chaperone mediated protein folding
RG65_RS20655	COG0745	RESPONSE REGULATOR receiver
RG65_RS20660	COG2205	protein histidine kinase activity
RG65_RS20665	COG2258	MOSC domain
RG65_RS20685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RG65_RS20730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS20735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS20735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RG65_RS20740	COG1363	Peptidase, m42
RG65_RS20745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS20745	COG3711	transcriptional antiterminator
RG65_RS20765	COG3383	formate dehydrogenase (NAD+) activity
RG65_RS20765	COG0243	molybdopterin cofactor binding
RG65_RS20770	COG0243	molybdopterin cofactor binding
RG65_RS20770	COG3383	formate dehydrogenase (NAD+) activity
RG65_RS20775	COG0437	4 iron, 4 sulfur cluster binding
RG65_RS20780	COG2864	formate dehydrogenase
RG65_RS20795	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG65_RS20800	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RG65_RS20805	COG0456	acetyltransferase
RG65_RS20820	COG1011	Hydrolase
RG65_RS20830	COG0477	Major facilitator Superfamily
RG65_RS20840	COG1063	alcohol dehydrogenase
RG65_RS20845	COG3684	Belongs to the aldolase LacD family
RG65_RS20850	COG2084	Dehydrogenase
RG65_RS20855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG65_RS20860	COG1349	DNA-binding transcription factor activity
RG65_RS20865	COG2271	Major facilitator Superfamily
RG65_RS20870	COG1082	Xylose isomerase domain protein TIM barrel
RG65_RS20875	COG2188	Transcriptional regulator
RG65_RS20880	COG1217	gtp-binding protein TYPA
RG65_RS20890	COG0174	glutamine synthetase
RG65_RS20895	COG3852	Histidine kinase
RG65_RS20900	COG2204	response regulator
RG65_RS20910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RG65_RS20915	COG3078	GTPase activator activity
RG65_RS20930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG65_RS20930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RG65_RS20940	COG0204	Acyl-transferase
RG65_RS20945	COG5339	Protein conserved in bacteria
RG65_RS20950	COG5339	Protein conserved in bacteria
RG65_RS20955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RG65_RS20960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RG65_RS20965	COG3084	Protein conserved in bacteria
RG65_RS20970	COG0746	molybdenum cofactor guanylyltransferase activity
RG65_RS20975	COG1763	Mo-molybdopterin cofactor biosynthetic process
RG65_RS21005	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
RG65_RS21010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RG65_RS21015	COG1739	Uncharacterized protein family UPF0029
RG65_RS21035	COG0543	2 iron, 2 sulfur cluster binding
RG65_RS21040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RG65_RS21045	COG0250	Participates in transcription elongation, termination and antitermination
RG65_RS21055	COG0805	protein transport
RG65_RS21060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG65_RS21065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RG65_RS21075	COG3165	ubiquinone biosynthetic process from chorismate
RG65_RS21085	COG1322	Protein conserved in bacteria
RG65_RS21095	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
RG65_RS21100	COG0412	Dienelactone hydrolase
RG65_RS21110	COG0583	DNA-binding transcription factor activity
RG65_RS21115	COG0697	spore germination
RG65_RS21120	COG0561	phosphatase activity
RG65_RS21125	COG2267	carboxylic ester hydrolase activity
RG65_RS21130	COG1280	lysine exporter protein (LysE YggA)
RG65_RS21135	COG1280	lysine exporter protein (LysE YggA)
RG65_RS21140	COG0514	ATP-dependent DNA helicase (RecQ)
RG65_RS21145	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RG65_RS21150	COG2050	protein possibly involved in aromatic compounds catabolism
RG65_RS21155	COG2962	Rard protein
RG65_RS21185	COG0598	Magnesium transport protein CorA
RG65_RS21195	COG3698	Phosphodiester glycosidase
RG65_RS21200	COG0210	DNA helicase
RG65_RS21205	COG1011	Hydrolase
RG65_RS21215	COG3159	Protein conserved in bacteria
RG65_RS21225	COG5567	small periplasmic lipoprotein
RG65_RS21255	COG3072	Adenylate cyclase
RG65_RS21270	COG1587	Uroporphyrinogen-III synthase
RG65_RS21275	COG2959	enzyme of heme biosynthesis
RG65_RS21280	COG3071	HemY protein
RG65_RS21285	COG3119	arylsulfatase activity
RG65_RS21290	COG0641	radical SAM
RG65_RS21315	COG1113	amino acid transport
RG65_RS21335	COG2244	polysaccharide biosynthetic process
RG65_RS21340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RG65_RS21345	COG0456	acetyltransferase
RG65_RS21350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RG65_RS21355	COG1088	dTDP-glucose 4,6-dehydratase activity
RG65_RS21360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RG65_RS21365	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RG65_RS21370	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
RG65_RS21375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RG65_RS21385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RG65_RS21395	COG3118	belongs to the thioredoxin family
RG65_RS21415	COG0210	DNA helicase
RG65_RS21420	COG3692	DNA binding
RG65_RS21425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RG65_RS21435	COG0583	DNA-binding transcription factor activity
RG65_RS21440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RG65_RS21450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RG65_RS21455	COG3978	acetolactate synthase activity
RG65_RS21470	COG0606	chelatase, subunit chli
RG65_RS21475	COG3085	chromosome segregation
RG65_RS21520	COG2186	Transcriptional regulator
RG65_RS21525	COG0477	Major facilitator Superfamily
RG65_RS21530	COG1609	Transcriptional regulator
RG65_RS21535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG65_RS21540	COG1879	ABC-type sugar transport system periplasmic component
RG65_RS21545	COG1172	Belongs to the binding-protein-dependent transport system permease family
RG65_RS21550	COG1129	ABC transporter
RG65_RS21580	COG1522	sequence-specific DNA binding
RG65_RS21585	COG0716	FMN binding
RG65_RS21600	COG3312	ion transport
RG65_RS21655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RG65_RS21670	COG3188	usher protein
RG65_RS21680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG65_RS21685	COG0573	inorganic phosphate transmembrane transporter activity
RG65_RS21690	COG0581	inorganic phosphate transmembrane transporter activity
RG65_RS21695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RG65_RS21700	COG0704	Plays a role in the regulation of phosphate uptake
RG65_RS21705	COG3711	transcriptional antiterminator
RG65_RS21710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RG65_RS21710	COG1263	PTS System
RG65_RS21710	COG2190	(PTS) system
RG65_RS21715	COG2723	6-phospho-beta-galactosidase activity
RG65_RS21725	COG2382	esterase
RG65_RS21730	COG0363	glucosamine-6-phosphate deaminase activity
RG65_RS21735	COG3196	Protein conserved in bacteria
RG65_RS21745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RG65_RS21750	COG2252	PERMEase
RG65_RS21755	COG0431	NADPH-dependent FMN reductase
RG65_RS21760	COG2091	lysine biosynthetic process via aminoadipic acid
RG65_RS21775	COG0814	amino acid
RG65_RS21825	COG0592	DNA-directed DNA polymerase activity
RG65_RS21835	COG0187	DNA topoisomerase II activity
RG65_RS21840	COG3753	Protein conserved in bacteria
RG65_RS21845	COG0561	phosphatase activity
RG65_RS21855	COG2186	Transcriptional regulator
RG65_RS21860	COG3734	2-keto-3-deoxy-galactonokinase
RG65_RS21865	COG0800	Aldolase
RG65_RS21875	COG2271	Major facilitator Superfamily
RG65_RS21885	COG0823	Involved in the tonB-independent uptake of proteins
RG65_RS21890	COG5645	(Lipo)protein
RG65_RS21915	COG2188	Transcriptional regulator
RG65_RS21935	COG2207	Transcriptional regulator
RG65_RS21940	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RG65_RS21945	COG3119	arylsulfatase activity
RG65_RS21955	COG2149	membrane
RG65_RS21965	COG0641	radical SAM
RG65_RS21970	COG2814	Major facilitator Superfamily
RG65_RS22005	COG0028	Belongs to the TPP enzyme family
RG65_RS22010	COG0440	acetolactate synthase activity
RG65_RS22015	COG2197	response regulator
RG65_RS22020	COG3851	Histidine kinase
RG65_RS22025	COG2271	Major facilitator Superfamily
RG65_RS22030	COG2271	Major facilitator Superfamily
RG65_RS22040	COG2252	PERMEase
RG65_RS22075	COG1464	Belongs to the NlpA lipoprotein family
RG65_RS22080	COG0697	spore germination
RG65_RS22085	COG2814	Major facilitator Superfamily
RG65_RS22100	COG2211	Major facilitator Superfamily
RG65_RS22105	COG1501	Belongs to the glycosyl hydrolase 31 family
RG65_RS22110	COG2982	Protein involved in outer membrane biogenesis
RG65_RS22115	COG2233	PERMEase
RG65_RS22120	COG0786	glutamate:sodium symporter activity
RG65_RS22130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RG65_RS22135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RG65_RS22140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RG65_RS22150	COG0194	GDP metabolic process
RG65_RS22160	COG2860	membrane
RG65_RS22165	COG3645	SOS response
RG65_RS22170	COG1561	YicC-like family, N-terminal region
RG65_RS22200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RG65_RS22230	COG1519	Transferase
RG65_RS22235	COG0859	PFAM glycosyl transferase family 9
RG65_RS22240	COG0438	transferase activity, transferring glycosyl groups
RG65_RS22245	COG0515	serine threonine protein kinase
RG65_RS22255	COG3642	lipopolysaccharide core region biosynthetic process
RG65_RS22275	COG0859	PFAM glycosyl transferase family 9
RG65_RS22280	COG0859	PFAM glycosyl transferase family 9
RG65_RS22295	COG0156	8-amino-7-oxononanoate synthase activity
RG65_RS22305	COG1216	Glycosyl transferase, family 2
RG65_RS22310	COG2861	carbohydrate metabolic process
RG65_RS22315	COG4942	peptidase
RG65_RS22330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RG65_RS22335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RG65_RS22350	COG1045	serine acetyltransferase
RG65_RS22355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RG65_RS22365	COG2186	Transcriptional regulator
RG65_RS22370	COG1620	l-lactate permease
RG65_RS22375	COG5295	Hep Hag repeat protein
RG65_RS22380	COG5295	Hep Hag repeat protein
RG65_RS22385	COG5295	Hep Hag repeat protein
RG65_RS22390	COG5295	Hep Hag repeat protein
RG65_RS22420	COG3722	fumarate hydratase activity
RG65_RS22430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RG65_RS22430	COG2213	PTS system mannitol-specific
RG65_RS22440	COG1566	PFAM secretion protein HlyD family protein
RG65_RS22465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RG65_RS22470	COG3209	COG3209 Rhs family protein
RG65_RS22475	COG1413	lyase activity
RG65_RS22495	COG0625	glutathione transferase activity
RG65_RS22505	COG3276	selenocysteine insertion sequence binding
RG65_RS22510	COG1454	alcohol dehydrogenase
RG65_RS22515	COG1012	belongs to the aldehyde dehydrogenase family
RG65_RS22530	COG1566	PFAM secretion protein HlyD family protein
RG65_RS22535	COG0583	DNA-binding transcription factor activity
RG65_RS22540	COG3713	MltA-interacting MipA family protein
RG65_RS22550	COG2211	Major facilitator Superfamily
RG65_RS22560	COG0235	Class ii aldolase
RG65_RS22565	COG3623	hexulose-6-phosphate isomerase
RG65_RS22570	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
RG65_RS22575	COG1070	Carbohydrate kinase
RG65_RS22580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RG65_RS22585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RG65_RS22590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RG65_RS22595	COG2731	YhcH YjgK YiaL family protein
RG65_RS22605	COG1414	Transcriptional regulator
RG65_RS22610	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RG65_RS22615	COG3977	Valine--pyruvate aminotransferase
RG65_RS22620	COG0366	Alpha amylase catalytic
RG65_RS22625	COG2992	FlgJ-related protein
RG65_RS22630	COG1609	Transcriptional regulator
RG65_RS22630	COG2207	Transcriptional regulator
RG65_RS22635	COG4214	carbohydrate transport
RG65_RS22640	COG1129	ABC transporter
RG65_RS22645	COG4213	ABC transporter substrate-binding protein
RG65_RS22655	COG1070	Carbohydrate kinase
RG65_RS22660	COG4682	membrane
RG65_RS22665	COG4682	membrane
RG65_RS22670	COG3274	enterobacterial common antigen metabolic process
RG65_RS22695	COG1278	Cold shock
RG65_RS22700	COG2944	sequence-specific DNA binding
RG65_RS22715	COG2885	chlorophyll binding
RG65_RS22720	COG0243	molybdopterin cofactor binding
RG65_RS22725	COG0456	acetyltransferase
RG65_RS22730	COG2818	Glycosylase
RG65_RS22735	COG5571	outer membrane autotransporter
RG65_RS22745	COG2223	nitrite transmembrane transporter activity
RG65_RS22775	COG2194	sulfuric ester hydrolase activity
RG65_RS22795	COG0747	negative chemotaxis
RG65_RS22805	COG0601	transmembrane transport
RG65_RS22810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG65_RS22815	COG0444	Belongs to the ABC transporter superfamily
RG65_RS22820	COG4608	Belongs to the ABC transporter superfamily
RG65_RS22825	COG0814	amino acid
RG65_RS22865	COG2194	sulfuric ester hydrolase activity
RG65_RS22890	COG1215	transferase activity, transferring glycosyl groups
RG65_RS22895	COG1215	transferase activity, transferring glycosyl groups
RG65_RS22900	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RG65_RS22905	COG0457	Tetratricopeptide repeat
RG65_RS22905	COG3118	belongs to the thioredoxin family
RG65_RS22910	COG2200	EAL domain
RG65_RS22910	COG2199	diguanylate cyclase activity
RG65_RS22930	COG0612	Peptidase, M16
RG65_RS22945	COG2200	EAL domain
RG65_RS22950	COG2982	Protein involved in outer membrane biogenesis
RG65_RS22955	COG0477	Major facilitator Superfamily
RG65_RS22960	COG1295	ribonuclease BN
RG65_RS22965	COG0583	DNA-binding transcription factor activity
RG65_RS22970	COG2197	response regulator
RG65_RS22980	COG1858	cytochrome C peroxidase
RG65_RS22985	COG0076	glutamate decarboxylase activity
RG65_RS22995	COG2207	Transcriptional regulator
RG65_RS23005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RG65_RS23010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG65_RS23020	COG2771	luxR family
RG65_RS23025	COG3247	response to pH
RG65_RS23040	COG1285	pathogenesis
RG65_RS23045	COG2197	response regulator
RG65_RS23055	COG3065	identical protein binding
RG65_RS23075	COG1393	Belongs to the ArsC family
RG65_RS23080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RG65_RS23085	COG0640	Transcriptional regulator
RG65_RS23100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RG65_RS23105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RG65_RS23110	COG0339	signal peptide processing
RG65_RS23120	COG3104	oligopeptide transport
RG65_RS23130	COG0589	response to stress
RG65_RS23140	COG0306	phosphate transporter
RG65_RS23145	COG2081	HI0933 family
RG65_RS23175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RG65_RS23180	COG0842	Transport permease protein
RG65_RS23180	COG1129	ABC transporter
RG65_RS23185	COG0842	Transport permease protein
RG65_RS23210	COG0444	Belongs to the ABC transporter superfamily
RG65_RS23215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RG65_RS23220	COG0601	transmembrane transport
RG65_RS23225	COG0747	negative chemotaxis
RG65_RS23230	COG2091	lysine biosynthetic process via aminoadipic acid
RG65_RS23235	COG0628	permease
RG65_RS23250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RG65_RS23265	COG3714	YhhN family
RG65_RS23275	COG3776	membrane
RG65_RS23280	COG0742	ribosomal rna small subunit methyltransferase
RG65_RS23285	COG0552	protein localization to endoplasmic reticulum
RG65_RS23290	COG2884	Cell division ATP-binding protein ftsE
RG65_RS23295	COG2177	Part of the ABC transporter FtsEX involved in
RG65_RS23300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RG65_RS23305	COG0683	leucine binding
RG65_RS23310	COG0456	acetyltransferase
RG65_RS23320	COG0683	leucine binding
RG65_RS23325	COG0559	Belongs to the binding-protein-dependent transport system permease family
RG65_RS23330	COG4177	L-phenylalanine transmembrane transporter activity
RG65_RS23335	COG0411	ABC transporter
RG65_RS23340	COG0410	ABC transporter
RG65_RS23350	COG1653	transport
RG65_RS23355	COG1175	transmembrane transport
RG65_RS23360	COG0395	ABC-type sugar transport system, permease component
RG65_RS23365	COG3842	ATPase activity
RG65_RS23370	COG0584	glycerophosphoryl diester phosphodiesterase
RG65_RS23380	COG0405	Gamma-glutamyltransferase
RG65_RS23400	COG3157	Type VI secretion system effector, Hcp
RG65_RS23405	COG1247	-acetyltransferase
RG65_RS23410	COG0673	inositol 2-dehydrogenase activity
RG65_RS23415	COG1741	Belongs to the pirin family
RG65_RS23420	COG1609	Transcriptional regulator
RG65_RS23425	COG3265	gluconokinase activity
RG65_RS23430	COG2610	gluconate transmembrane transporter activity
RG65_RS23435	COG0514	ATP-dependent DNA helicase (RecQ)
RG65_RS23445	COG2095	MarC family integral membrane protein
RG65_RS23450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RG65_RS23475	COG0058	SHG alpha-glucan phosphorylase activity
RG65_RS23480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RG65_RS23500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RG65_RS23515	COG1349	DNA-binding transcription factor activity
RG65_RS23520	COG4650	regulator
RG65_RS23525	COG1690	Belongs to the RtcB family
RG65_RS23540	COG0058	SHG alpha-glucan phosphorylase activity
RG65_RS23545	COG1640	4-alpha-glucanotransferase
RG65_RS23550	COG2610	gluconate transmembrane transporter activity
RG65_RS23560	COG1040	competence protein
RG65_RS23570	COG5464	transposase or invertase
RG65_RS23585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RG65_RS23590	COG1918	ferrous iron import across plasma membrane
RG65_RS23600	COG2183	response to ionizing radiation
RG65_RS23605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RG65_RS23635	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RG65_RS23645	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RG65_RS23650	COG1011	Hydrolase
RG65_RS23660	COG0494	nUDIX hydrolase
RG65_RS23665	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RG65_RS23670	COG4972	Pilus assembly protein
RG65_RS23675	COG3166	PFAM Fimbrial assembly family protein
RG65_RS23690	COG4796	Type ii and iii secretion system protein
RG65_RS23710	COG3266	domain, Protein
RG65_RS23715	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RG65_RS23720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RG65_RS23730	COG0180	Tryptophanyl-tRNA synthetase
RG65_RS23735	COG2188	Transcriptional regulator
RG65_RS23745	COG3457	Alanine racemase
RG65_RS23750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RG65_RS23755	COG1735	metal-dependent hydrolase with the TIM-barrel fold
RG65_RS23770	COG0626	cystathionine gamma-synthase activity
RG65_RS23775	COG2188	Transcriptional regulator
RG65_RS23780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RG65_RS23785	COG1082	Xylose isomerase domain protein TIM barrel
RG65_RS23790	COG1082	Xylose isomerase domain protein TIM barrel
RG65_RS23795	COG2222	sugar isomerase
RG65_RS23800	COG0531	amino acid
RG65_RS23815	COG2116	formate transmembrane transporter activity
RG65_RS23820	COG2146	nitrite reductase [NAD(P)H] activity
RG65_RS23825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RG65_RS23840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RG65_RS23850	COG2184	nucleotidyltransferase activity
RG65_RS23855	COG0512	Glutamine amidotransferase of anthranilate synthase
RG65_RS23860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RG65_RS23865	COG1289	transmembrane transporter activity
RG65_RS23870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RG65_RS23880	COG1765	OsmC-like protein
RG65_RS23885	COG3954	Phosphoribulokinase
RG65_RS23895	COG0429	hydrolase of the alpha beta-hydrolase fold
RG65_RS23900	COG0488	(ABC) transporter
RG65_RS23920	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
RG65_RS23925	COG1047	Peptidyl-prolyl cis-trans
RG65_RS23935	COG0545	Peptidyl-prolyl cis-trans isomerase
RG65_RS23940	COG2964	Protein conserved in bacteria
RG65_RS24020	COG0089	rRNA binding
RG65_RS24110	COG0201	protein transport
RG65_RS24150	COG0789	Transcriptional regulator
RG65_RS24155	COG3036	rescue of stalled ribosome
RG65_RS24165	COG0569	domain protein
RG65_RS24185	COG0758	DNA mediated transformation
RG65_RS24195	COG0551	DNA topoisomerase type I activity
RG65_RS24215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily