locus-tag	class	description
G4235_RS00010	COG0592	DNA-directed DNA polymerase activity
G4235_RS00020	COG0187	DNA topoisomerase II activity
G4235_RS00025	COG3753	Protein conserved in bacteria
G4235_RS00030	COG0561	phosphatase activity
G4235_RS00040	COG2186	Transcriptional regulator
G4235_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
G4235_RS00050	COG0800	Aldolase
G4235_RS00060	COG2271	Major facilitator Superfamily
G4235_RS00065	COG0644	oxidoreductase
G4235_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
G4235_RS00075	COG5645	(Lipo)protein
G4235_RS00095	COG2207	Transcriptional regulator
G4235_RS00100	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4235_RS00105	COG3119	arylsulfatase activity
G4235_RS00110	COG2149	membrane
G4235_RS00120	COG0641	radical SAM
G4235_RS00125	COG2814	Major facilitator Superfamily
G4235_RS00135	COG0028	Belongs to the TPP enzyme family
G4235_RS00140	COG0440	acetolactate synthase activity
G4235_RS00150	COG2197	response regulator
G4235_RS00155	COG3851	Histidine kinase
G4235_RS00160	COG2271	Major facilitator Superfamily
G4235_RS00165	COG2271	Major facilitator Superfamily
G4235_RS00170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G4235_RS00175	COG2252	PERMEase
G4235_RS00185	COG2814	Major facilitator Superfamily
G4235_RS00195	COG1464	Belongs to the NlpA lipoprotein family
G4235_RS00200	COG0697	spore germination
G4235_RS00235	COG3344	reverse transcriptase
G4235_RS00250	COG2003	Belongs to the UPF0758 family
G4235_RS00275	COG2378	regulation of single-species biofilm formation
G4235_RS00280	COG3596	GTP binding
G4235_RS00310	COG4771	TonB-dependent receptor
G4235_RS00350	COG2963	transposase activity
G4235_RS00355	COG2801	Transposase and inactivated derivatives
G4235_RS00360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4235_RS00445	COG3436	PFAM IS66 Orf2 family protein
G4235_RS00475	COG3539	Fimbrial protein
G4235_RS00550	COG1121	(ABC) transporter
G4235_RS00555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4235_RS00560	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4235_RS00580	COG2274	protein secretion by the type I secretion system
G4235_RS00590	COG4413	Urea transporter
G4235_RS00605	COG2194	sulfuric ester hydrolase activity
G4235_RS00615	COG0582	viral genome integration into host DNA
G4235_RS00625	COG2211	Major facilitator Superfamily
G4235_RS00630	COG1501	Belongs to the glycosyl hydrolase 31 family
G4235_RS00635	COG3711	transcriptional antiterminator
G4235_RS00640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS00640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS00640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS00645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS00650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS00650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS00660	COG0191	fructose-bisphosphate aldolase activity
G4235_RS00665	COG1940	carbohydrate kinase activity
G4235_RS00675	COG2982	Protein involved in outer membrane biogenesis
G4235_RS00680	COG2233	PERMEase
G4235_RS00685	COG0786	glutamate:sodium symporter activity
G4235_RS00690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4235_RS00695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4235_RS00700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4235_RS00710	COG0194	GDP metabolic process
G4235_RS00715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4235_RS00720	COG2860	membrane
G4235_RS00725	COG3645	SOS response
G4235_RS00730	COG1561	YicC-like family, N-terminal region
G4235_RS00755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4235_RS00775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4235_RS00785	COG1519	Transferase
G4235_RS00790	COG0859	PFAM glycosyl transferase family 9
G4235_RS00795	COG0438	transferase activity, transferring glycosyl groups
G4235_RS00800	COG0515	serine threonine protein kinase
G4235_RS00815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G4235_RS00820	COG1442	glycosyl transferase family 8
G4235_RS00825	COG1216	Glycosyl transferase, family 2
G4235_RS00830	COG3307	-O-antigen
G4235_RS00835	COG0859	PFAM glycosyl transferase family 9
G4235_RS00840	COG0859	PFAM glycosyl transferase family 9
G4235_RS00850	COG0156	8-amino-7-oxononanoate synthase activity
G4235_RS00860	COG1216	Glycosyl transferase, family 2
G4235_RS00865	COG2861	carbohydrate metabolic process
G4235_RS00870	COG4942	peptidase
G4235_RS00880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4235_RS00885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4235_RS00900	COG1045	serine acetyltransferase
G4235_RS00905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4235_RS00915	COG2186	Transcriptional regulator
G4235_RS00920	COG1620	l-lactate permease
G4235_RS00925	COG5295	Hep Hag repeat protein
G4235_RS00945	COG3722	fumarate hydratase activity
G4235_RS00955	COG2213	PTS system mannitol-specific
G4235_RS00955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS00965	COG1566	PFAM secretion protein HlyD family protein
G4235_RS00970	COG0625	glutathione transferase activity
G4235_RS00980	COG3276	selenocysteine insertion sequence binding
G4235_RS00985	COG1454	alcohol dehydrogenase
G4235_RS00995	COG1012	belongs to the aldehyde dehydrogenase family
G4235_RS01000	COG0235	Class ii aldolase
G4235_RS01005	COG3623	hexulose-6-phosphate isomerase
G4235_RS01010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
G4235_RS01015	COG1070	Carbohydrate kinase
G4235_RS01020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G4235_RS01025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G4235_RS01030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G4235_RS01040	COG2731	YhcH YjgK YiaL family protein
G4235_RS01050	COG1414	Transcriptional regulator
G4235_RS01055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS01060	COG3977	Valine--pyruvate aminotransferase
G4235_RS01065	COG0366	Alpha amylase catalytic
G4235_RS01070	COG2992	FlgJ-related protein
G4235_RS01075	COG1609	Transcriptional regulator
G4235_RS01075	COG2207	Transcriptional regulator
G4235_RS01080	COG4214	carbohydrate transport
G4235_RS01090	COG4213	ABC transporter substrate-binding protein
G4235_RS01100	COG1070	Carbohydrate kinase
G4235_RS01105	COG4682	membrane
G4235_RS01110	COG4682	membrane
G4235_RS01115	COG3274	enterobacterial common antigen metabolic process
G4235_RS01140	COG1278	Cold shock
G4235_RS01145	COG2944	sequence-specific DNA binding
G4235_RS01155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4235_RS01160	COG2885	chlorophyll binding
G4235_RS01165	COG0243	molybdopterin cofactor binding
G4235_RS01170	COG0456	acetyltransferase
G4235_RS01175	COG2818	Glycosylase
G4235_RS01180	COG5571	outer membrane autotransporter
G4235_RS01185	COG2223	nitrite transmembrane transporter activity
G4235_RS01190	COG2194	sulfuric ester hydrolase activity
G4235_RS01200	COG0747	negative chemotaxis
G4235_RS01210	COG0601	transmembrane transport
G4235_RS01215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4235_RS01220	COG0444	Belongs to the ABC transporter superfamily
G4235_RS01225	COG4608	Belongs to the ABC transporter superfamily
G4235_RS01230	COG0814	amino acid
G4235_RS01245	COG2194	sulfuric ester hydrolase activity
G4235_RS01270	COG1215	transferase activity, transferring glycosyl groups
G4235_RS01275	COG1215	transferase activity, transferring glycosyl groups
G4235_RS01280	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
G4235_RS01285	COG0457	Tetratricopeptide repeat
G4235_RS01285	COG3118	belongs to the thioredoxin family
G4235_RS01290	COG2200	EAL domain
G4235_RS01290	COG2199	diguanylate cyclase activity
G4235_RS01300	COG0612	Peptidase, M16
G4235_RS01305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS01310	COG2200	EAL domain
G4235_RS01315	COG2982	Protein involved in outer membrane biogenesis
G4235_RS01320	COG0477	Major facilitator Superfamily
G4235_RS01325	COG1295	ribonuclease BN
G4235_RS01330	COG0583	DNA-binding transcription factor activity
G4235_RS01335	COG2197	response regulator
G4235_RS01345	COG1858	cytochrome C peroxidase
G4235_RS01350	COG0076	glutamate decarboxylase activity
G4235_RS01355	COG2207	Transcriptional regulator
G4235_RS01360	COG2207	Transcriptional regulator
G4235_RS01365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4235_RS01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS01380	COG2771	luxR family
G4235_RS01385	COG3247	response to pH
G4235_RS01400	COG1285	pathogenesis
G4235_RS01410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4235_RS01420	COG3721	Heme iron utilization protein
G4235_RS01435	COG4771	TonB-dependent receptor
G4235_RS01440	COG3720	iron ion transport
G4235_RS01445	COG2197	response regulator
G4235_RS01450	COG3065	identical protein binding
G4235_RS01460	COG1393	Belongs to the ArsC family
G4235_RS01470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4235_RS01475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G4235_RS01480	COG0339	signal peptide processing
G4235_RS01490	COG3104	oligopeptide transport
G4235_RS01495	COG0589	response to stress
G4235_RS01505	COG0306	phosphate transporter
G4235_RS01510	COG2081	HI0933 family
G4235_RS01520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS01525	COG0842	Transport permease protein
G4235_RS01525	COG1129	ABC transporter
G4235_RS01530	COG0842	Transport permease protein
G4235_RS01535	COG0191	fructose-bisphosphate aldolase activity
G4235_RS01550	COG3775	system Galactitol-specific IIC component
G4235_RS01555	COG3414	Phosphotransferase system galactitol-specific IIB component
G4235_RS01565	COG2188	Transcriptional regulator
G4235_RS01580	COG0444	Belongs to the ABC transporter superfamily
G4235_RS01585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4235_RS01590	COG0601	transmembrane transport
G4235_RS01595	COG0747	negative chemotaxis
G4235_RS01600	COG2091	lysine biosynthetic process via aminoadipic acid
G4235_RS01605	COG0628	permease
G4235_RS01610	COG0477	Major facilitator Superfamily
G4235_RS01620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G4235_RS01635	COG3714	YhhN family
G4235_RS01645	COG3776	membrane
G4235_RS01650	COG0742	ribosomal rna small subunit methyltransferase
G4235_RS01655	COG0552	protein localization to endoplasmic reticulum
G4235_RS01660	COG2884	Cell division ATP-binding protein ftsE
G4235_RS01665	COG2177	Part of the ABC transporter FtsEX involved in
G4235_RS01670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4235_RS01675	COG0683	leucine binding
G4235_RS01680	COG0456	acetyltransferase
G4235_RS01685	COG0683	leucine binding
G4235_RS01690	COG0559	Belongs to the binding-protein-dependent transport system permease family
G4235_RS01695	COG4177	L-phenylalanine transmembrane transporter activity
G4235_RS01700	COG0411	ABC transporter
G4235_RS01705	COG0410	ABC transporter
G4235_RS01715	COG1175	transmembrane transport
G4235_RS01725	COG3842	ATPase activity
G4235_RS01730	COG0584	glycerophosphoryl diester phosphodiesterase
G4235_RS01740	COG0405	Gamma-glutamyltransferase
G4235_RS01760	COG3157	Type VI secretion system effector, Hcp
G4235_RS01770	COG0673	inositol 2-dehydrogenase activity
G4235_RS01775	COG1741	Belongs to the pirin family
G4235_RS01780	COG1609	Transcriptional regulator
G4235_RS01785	COG3265	gluconokinase activity
G4235_RS01790	COG2610	gluconate transmembrane transporter activity
G4235_RS01795	COG0514	ATP-dependent DNA helicase (RecQ)
G4235_RS01805	COG2095	MarC family integral membrane protein
G4235_RS01810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4235_RS01815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G4235_RS01820	COG1523	belongs to the glycosyl hydrolase 13 family
G4235_RS01835	COG0058	SHG alpha-glucan phosphorylase activity
G4235_RS01845	COG3121	Chaperone
G4235_RS01850	COG3188	usher protein
G4235_RS01890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4235_RS01905	COG1349	DNA-binding transcription factor activity
G4235_RS01910	COG4650	regulator
G4235_RS01915	COG1690	Belongs to the RtcB family
G4235_RS01925	COG2909	trisaccharide binding
G4235_RS01930	COG0058	SHG alpha-glucan phosphorylase activity
G4235_RS01935	COG1640	4-alpha-glucanotransferase
G4235_RS01940	COG2610	gluconate transmembrane transporter activity
G4235_RS01950	COG1040	competence protein
G4235_RS01955	COG0596	Alpha beta hydrolase
G4235_RS01970	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G4235_RS01975	COG1918	ferrous iron import across plasma membrane
G4235_RS01980	COG2183	response to ionizing radiation
G4235_RS01985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4235_RS01990	COG0745	RESPONSE REGULATOR receiver
G4235_RS01995	COG2205	protein histidine kinase activity
G4235_RS02010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G4235_RS02015	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
G4235_RS02025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4235_RS02030	COG1011	Hydrolase
G4235_RS02040	COG0494	nUDIX hydrolase
G4235_RS02045	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G4235_RS02050	COG4972	Pilus assembly protein
G4235_RS02055	COG3166	PFAM Fimbrial assembly family protein
G4235_RS02070	COG4796	Type ii and iii secretion system protein
G4235_RS02085	COG3266	domain, Protein
G4235_RS02090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
G4235_RS02095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4235_RS02100	COG0546	phosphoglycolate phosphatase activity
G4235_RS02105	COG0180	Tryptophanyl-tRNA synthetase
G4235_RS02110	COG2188	Transcriptional regulator
G4235_RS02120	COG3457	Alanine racemase
G4235_RS02125	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G4235_RS02130	COG1735	metal-dependent hydrolase with the TIM-barrel fold
G4235_RS02145	COG0626	cystathionine gamma-synthase activity
G4235_RS02160	COG2116	formate transmembrane transporter activity
G4235_RS02165	COG2146	nitrite reductase [NAD(P)H] activity
G4235_RS02170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4235_RS02180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4235_RS02190	COG2184	nucleotidyltransferase activity
G4235_RS02195	COG0512	Glutamine amidotransferase of anthranilate synthase
G4235_RS02200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4235_RS02205	COG1289	transmembrane transporter activity
G4235_RS02210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4235_RS02215	COG1765	OsmC-like protein
G4235_RS02220	COG3954	Phosphoribulokinase
G4235_RS02230	COG0429	hydrolase of the alpha beta-hydrolase fold
G4235_RS02235	COG0488	(ABC) transporter
G4235_RS02250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
G4235_RS02255	COG1047	Peptidyl-prolyl cis-trans
G4235_RS02265	COG0545	Peptidyl-prolyl cis-trans isomerase
G4235_RS02270	COG2964	Protein conserved in bacteria
G4235_RS02310	COG3979	chitinase
G4235_RS02315	COG2906	2 iron, 2 sulfur cluster binding
G4235_RS02320	COG2193	ferroxidase activity
G4235_RS02325	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G4235_RS02330	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
G4235_RS02335	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
G4235_RS02340	COG3156	type II secretion system protein K
G4235_RS02345	COG4795	General secretion pathway protein
G4235_RS02350	COG2165	general secretion pathway protein
G4235_RS02355	COG2165	general secretion pathway protein
G4235_RS02360	COG2165	general secretion pathway protein
G4235_RS02365	COG1459	type II secretion system
G4235_RS02370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4235_RS02375	COG1450	Type ii and iii secretion system protein
G4235_RS02380	COG3031	protein transport across the cell outer membrane
G4235_RS02385	COG3267	Type II secretory pathway component ExeA
G4235_RS02385	COG3409	Peptidoglycan-binding domain 1 protein
G4235_RS02410	COG0089	rRNA binding
G4235_RS02500	COG0201	protein transport
G4235_RS02540	COG0789	Transcriptional regulator
G4235_RS02545	COG3036	rescue of stalled ribosome
G4235_RS02555	COG0569	domain protein
G4235_RS02560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4235_RS02560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4235_RS02565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4235_RS02575	COG0758	DNA mediated transformation
G4235_RS02585	COG0551	DNA topoisomerase type I activity
G4235_RS02590	COG0009	L-threonylcarbamoyladenylate synthase
G4235_RS02595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4235_RS02605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4235_RS02645	COG1126	abc transporter atp-binding protein
G4235_RS02650	COG0765	amino acid transport
G4235_RS02655	COG4597	amino acid ABC transporter
G4235_RS02660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4235_RS02670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4235_RS02675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS02680	COG1309	transcriptional regulator
G4235_RS02690	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G4235_RS02700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4235_RS02710	COG4145	pantothenate transmembrane transporter activity
G4235_RS02715	COG3924	membrane
G4235_RS02720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS02725	COG1349	DNA-binding transcription factor activity
G4235_RS02735	COG1879	ABC-type sugar transport system periplasmic component
G4235_RS02740	COG1129	ABC transporter
G4235_RS02745	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4235_RS02750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS02760	COG0439	Biotin carboxylase
G4235_RS02765	COG0511	ligase activity, forming carbon-carbon bonds
G4235_RS02775	COG0604	alcohol dehydrogenase
G4235_RS02780	COG2200	EAL domain
G4235_RS02780	COG2199	diguanylate cyclase activity
G4235_RS02785	COG1077	Cell shape determining protein MreB Mrl
G4235_RS02790	COG1792	Involved in formation and maintenance of cell shape
G4235_RS02795	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G4235_RS02805	COG1530	ribonuclease E activity
G4235_RS02810	COG3164	Protein of unknown function
G4235_RS02815	COG0312	modulator of DNA gyrase
G4235_RS02820	COG0583	DNA-binding transcription factor activity
G4235_RS02835	COG1289	transmembrane transporter activity
G4235_RS02840	COG2732	(Barnase) inhibitor
G4235_RS02860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4235_RS02865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4235_RS02870	COG3105	Protein conserved in bacteria
G4235_RS02875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G4235_RS02890	COG0625	glutathione transferase activity
G4235_RS02895	COG2969	positive regulation of protein catabolic process
G4235_RS02910	COG2814	Major facilitator Superfamily
G4235_RS02920	COG1940	carbohydrate kinase activity
G4235_RS02925	COG2731	YhcH YjgK YiaL family protein
G4235_RS02930	COG0493	'glutamate synthase
G4235_RS02935	COG0069	glutamate synthase activity
G4235_RS02935	COG0067	glutamate synthase
G4235_RS02935	COG0070	glutamate synthase
G4235_RS02940	COG1242	4 iron, 4 sulfur cluster binding
G4235_RS02945	COG5002	protein histidine kinase activity
G4235_RS02945	COG0784	Response regulator, receiver
G4235_RS02945	COG2198	Histidine kinase
G4235_RS02950	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
G4235_RS02960	COG0515	serine threonine protein kinase
G4235_RS02965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS02980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4235_RS02985	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G4235_RS02990	COG1137	ATPase activity
G4235_RS02995	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G4235_RS03000	COG3117	lipopolysaccharide transmembrane transporter activity
G4235_RS03005	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G4235_RS03010	COG0517	IMP dehydrogenase activity
G4235_RS03010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G4235_RS03015	COG0530	calcium, potassium:sodium antiporter activity
G4235_RS03020	COG1127	ABC transporter
G4235_RS03025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4235_RS03030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4235_RS03035	COG2854	intermembrane phospholipid transfer
G4235_RS03040	COG3113	response to antibiotic
G4235_RS03045	COG5007	Belongs to the BolA IbaG family
G4235_RS03055	COG3423	Transcriptional regulator
G4235_RS03060	COG0142	geranyltranstransferase activity
G4235_RS03075	COG0697	spore germination
G4235_RS03085	COG2027	D-alanyl-D-alanine carboxypeptidase
G4235_RS03090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4235_RS03095	COG1534	Rna-binding protein
G4235_RS03105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4235_RS03110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4235_RS03120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4235_RS03130	COG2194	sulfuric ester hydrolase activity
G4235_RS03150	COG0195	Participates in both transcription termination and antitermination
G4235_RS03190	COG0513	Belongs to the DEAD box helicase family
G4235_RS03195	COG0814	amino acid
G4235_RS03200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4235_RS03205	COG0826	peptidase U32
G4235_RS03210	COG0826	peptidase U32
G4235_RS03215	COG3154	lipid carrier protein
G4235_RS03220	COG3153	acetyltransferase
G4235_RS03235	COG0702	epimerase
G4235_RS03240	COG0701	Predicted permease
G4235_RS03245	COG2823	Periplasmic or secreted lipoprotein
G4235_RS03260	COG3107	peptidoglycan biosynthetic process
G4235_RS03265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G4235_RS03270	COG0363	glucosamine-6-phosphate deaminase activity
G4235_RS03275	COG3716	PTS system mannose fructose sorbose family IID component
G4235_RS03280	COG3715	PTS system
G4235_RS03285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS03295	COG2222	sugar isomerase
G4235_RS03300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4235_RS03305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS03310	COG3716	PTS system mannose fructose sorbose family IID component
G4235_RS03320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS03330	COG1349	DNA-binding transcription factor activity
G4235_RS03340	COG2002	toxin-antitoxin pair type II binding
G4235_RS03345	COG2721	sulfolactate sulfo-lyase activity
G4235_RS03350	COG2271	Major facilitator Superfamily
G4235_RS03355	COG3836	Belongs to the HpcH HpaI aldolase family
G4235_RS03360	COG2084	Dehydrogenase
G4235_RS03365	COG1929	Belongs to the glycerate kinase type-1 family
G4235_RS03380	COG0583	DNA-binding transcription factor activity
G4235_RS03385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4235_RS03395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4235_RS03400	COG1882	Formate acetyltransferase
G4235_RS03405	COG0251	oxidation-reduction process
G4235_RS03410	COG1760	l-serine dehydratase
G4235_RS03415	COG0814	amino acid
G4235_RS03430	COG1741	Belongs to the pirin family
G4235_RS03435	COG0583	DNA-binding transcription factor activity
G4235_RS03440	COG3152	Membrane
G4235_RS03445	COG0435	Glutathione S-transferase
G4235_RS03450	COG2259	Doxx family
G4235_RS03460	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
G4235_RS03465	COG4575	ribosome binding
G4235_RS03470	COG1422	Protein of unknown function (DUF1090)
G4235_RS03480	COG0586	Pfam SNARE associated Golgi protein
G4235_RS03485	COG2186	Transcriptional regulator
G4235_RS03490	COG2271	Major facilitator Superfamily
G4235_RS03500	COG2721	sulfolactate sulfo-lyase activity
G4235_RS03510	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
G4235_RS03515	COG0861	Integral membrane protein TerC family
G4235_RS03520	COG0673	inositol 2-dehydrogenase activity
G4235_RS03525	COG2949	membrane
G4235_RS03530	COG1451	nucleotide metabolic process
G4235_RS03545	COG5499	transcription regulator containing HTH domain
G4235_RS03550	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4235_RS03550	COG1902	pentaerythritol trinitrate reductase activity
G4235_RS03555	COG3408	Glycogen debranching enzyme
G4235_RS03555	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
G4235_RS03565	COG0531	amino acid
G4235_RS03570	COG2731	YhcH YjgK YiaL family protein
G4235_RS03575	COG3250	beta-galactosidase activity
G4235_RS03580	COG1609	Transcriptional regulator
G4235_RS03585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4235_RS03590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4235_RS03595	COG0840	transmembrane signaling receptor activity
G4235_RS03600	COG1695	Transcriptional regulator
G4235_RS03605	COG2375	cellular response to nickel ion
G4235_RS03620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4235_RS03625	COG0358	DNA primase activity
G4235_RS03630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G4235_RS03645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4235_RS03665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4235_RS03675	COG0617	tRNA 3'-terminal CCA addition
G4235_RS03680	COG4991	sh3 domain protein
G4235_RS03685	COG0675	Transposase, IS605 OrfB family
G4235_RS03695	COG3025	triphosphatase activity
G4235_RS03700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G4235_RS03715	COG2268	Band 7 protein
G4235_RS03720	COG1585	Membrane protein implicated in regulation of membrane protease activity
G4235_RS03740	COG3539	Fimbrial protein
G4235_RS03745	COG3121	Chaperone
G4235_RS03750	COG3188	usher protein
G4235_RS03755	COG3539	Fimbrial protein
G4235_RS03770	COG3384	dioxygenase
G4235_RS03780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G4235_RS03790	COG0754	glutathionylspermidine amidase activity
G4235_RS03800	COG1538	Outer membrane efflux protein
G4235_RS03805	COG0494	nUDIX hydrolase
G4235_RS03810	COG3151	Protein conserved in bacteria
G4235_RS03815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4235_RS03820	COG3150	esterase
G4235_RS03825	COG0187	DNA topoisomerase II activity
G4235_RS03830	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
G4235_RS03835	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4235_RS03845	COG0642	Histidine kinase
G4235_RS03850	COG0745	RESPONSE REGULATOR receiver
G4235_RS03855	COG3111	PFAM Bacterial OB fold (BOF) protein
G4235_RS03860	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
G4235_RS03870	COG2944	sequence-specific DNA binding
G4235_RS03875	COG4166	transmembrane transport
G4235_RS03880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4235_RS03885	COG0204	Acyl-transferase
G4235_RS03890	COG2132	Multicopper oxidase
G4235_RS03910	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4235_RS03915	COG1063	alcohol dehydrogenase
G4235_RS03925	COG2186	Transcriptional regulator
G4235_RS03930	COG1032	radical SAM domain protein
G4235_RS03935	COG4238	major outer membrane lipoprotein
G4235_RS03950	COG1979	alcohol dehydrogenase
G4235_RS03955	COG2207	Transcriptional regulator
G4235_RS03960	COG0586	Pfam SNARE associated Golgi protein
G4235_RS03965	COG0626	cystathionine gamma-synthase activity
G4235_RS03970	COG0811	peptide transport
G4235_RS03975	COG0848	biopolymer transport protein
G4235_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS03990	COG0667	Aldo Keto reductase
G4235_RS04005	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G4235_RS04010	COG0437	4 iron, 4 sulfur cluster binding
G4235_RS04015	COG5557	Pfam Polysulphide reductase, NrfD
G4235_RS04020	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G4235_RS04025	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4235_RS04030	COG1773	rubredoxin
G4235_RS04035	COG0375	protein maturation
G4235_RS04040	COG0298	carbon dioxide binding
G4235_RS04045	COG0625	glutathione transferase activity
G4235_RS04050	COG0754	glutathionylspermidine amidase activity
G4235_RS04060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4235_RS04065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4235_RS04070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4235_RS04075	COG2244	polysaccharide biosynthetic process
G4235_RS04085	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
G4235_RS04090	COG0795	lipopolysaccharide-transporting ATPase activity
G4235_RS04100	COG0156	8-amino-7-oxononanoate synthase activity
G4235_RS04105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4235_RS04115	COG0318	PFAM AMP-dependent synthetase and ligase
G4235_RS04120	COG0456	acetyltransferase
G4235_RS04125	COG2186	Transcriptional regulator
G4235_RS04130	COG0277	FAD linked oxidase domain protein
G4235_RS04135	COG0277	FAD linked oxidase domain protein
G4235_RS04140	COG0247	lactate metabolic process
G4235_RS04145	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G4235_RS04150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G4235_RS04155	COG1620	l-lactate permease
G4235_RS04160	COG3385	transposase activity
G4235_RS04175	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
G4235_RS04190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4235_RS04200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G4235_RS04240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G4235_RS04240	COG0517	IMP dehydrogenase activity
G4235_RS04295	COG2003	Belongs to the UPF0758 family
G4235_RS04320	COG2020	methyltransferase activity
G4235_RS04325	COG2433	Pfam Transposase IS66
G4235_RS04340	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS04350	COG4983	Phage plasmid primase, P4 family domain protein
G4235_RS04390	COG4372	Transposase
G4235_RS04400	COG3436	PFAM IS66 Orf2 family protein
G4235_RS04415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4235_RS04420	COG1940	carbohydrate kinase activity
G4235_RS04425	COG2814	Major facilitator Superfamily
G4235_RS04435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G4235_RS04440	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
G4235_RS04445	COG0657	acetylesterase activity
G4235_RS04445	COG2755	lipolytic protein G-D-S-L family
G4235_RS04495	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS04510	COG3436	PFAM IS66 Orf2 family protein
G4235_RS04530	COG4771	TonB-dependent receptor
G4235_RS04675	COG3436	PFAM IS66 Orf2 family protein
G4235_RS04735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G4235_RS04755	COG1595	DNA-templated transcription, initiation
G4235_RS04760	COG3712	iron ion homeostasis
G4235_RS04765	COG4772	TonB-dependent receptor
G4235_RS04770	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
G4235_RS04775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4235_RS04780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4235_RS04785	COG1120	ATPase activity
G4235_RS04790	COG2085	NADP oxidoreductase coenzyme F420-dependent
G4235_RS04815	COG5002	protein histidine kinase activity
G4235_RS04820	COG0745	RESPONSE REGULATOR receiver
G4235_RS04825	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
G4235_RS04830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4235_RS04850	COG2274	protein secretion by the type I secretion system
G4235_RS04885	COG3436	PFAM IS66 Orf2 family protein
G4235_RS04895	COG3547	Transposase (IS116 IS110 IS902 family)
G4235_RS04905	COG1309	transcriptional regulator
G4235_RS04915	COG1304	FMN binding
G4235_RS04920	COG2259	Doxx family
G4235_RS04980	COG3539	Fimbrial protein
G4235_RS05055	COG2194	sulfuric ester hydrolase activity
G4235_RS05065	COG0582	viral genome integration into host DNA
G4235_RS05075	COG1811	Na channel or pump
G4235_RS05080	COG1982	Orn Lys Arg decarboxylase major
G4235_RS05085	COG2211	Major facilitator Superfamily
G4235_RS05095	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G4235_RS05100	COG1194	a g-specific adenine glycosylase
G4235_RS05110	COG3171	Protein conserved in bacteria
G4235_RS05120	COG0252	asparaginase activity
G4235_RS05130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4235_RS05135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4235_RS05145	COG0762	integral membrane protein
G4235_RS05150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G4235_RS05155	COG2805	Type II/IV secretion system protein
G4235_RS05170	COG0189	ligase activity
G4235_RS05175	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4235_RS05180	COG2356	endonuclease I
G4235_RS05190	COG2814	Major facilitator Superfamily
G4235_RS05210	COG1166	arginine decarboxylase activity
G4235_RS05225	COG0501	Belongs to the peptidase M48B family
G4235_RS05230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4235_RS05235	COG0330	HflC and HflK could
G4235_RS05240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS05245	COG2213	PTS system mannitol-specific
G4235_RS05250	COG1063	alcohol dehydrogenase
G4235_RS05265	COG1072	(Pantothenic acid kinase))
G4235_RS05270	COG1122	ATPase activity
G4235_RS05305	COG0191	fructose-bisphosphate aldolase activity
G4235_RS05310	COG0668	transmembrane transport
G4235_RS05315	COG1279	arginine transmembrane transporter activity
G4235_RS05320	COG2968	Membrane
G4235_RS05325	COG0583	DNA-binding transcription factor activity
G4235_RS05330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4235_RS05330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4235_RS05350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4235_RS05360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4235_RS05380	COG0006	proline dipeptidase activity
G4235_RS05385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4235_RS05390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4235_RS05400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G4235_RS05410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4235_RS05410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4235_RS05415	COG2723	6-phospho-beta-galactosidase activity
G4235_RS05425	COG1272	protein, Hemolysin III
G4235_RS05430	COG0354	folic acid binding
G4235_RS05435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G4235_RS05445	COG0716	FMN binding
G4235_RS05450	COG4974	Belongs to the 'phage' integrase family
G4235_RS05455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4235_RS05460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4235_RS05470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4235_RS05475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G4235_RS05490	COG2233	PERMEase
G4235_RS05500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS05505	COG2252	PERMEase
G4235_RS05510	COG0402	S-adenosylhomocysteine deaminase activity
G4235_RS05515	COG2233	PERMEase
G4235_RS05520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4235_RS05520	COG2080	2 iron, 2 sulfur cluster binding
G4235_RS05525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4235_RS05530	COG0402	S-adenosylhomocysteine deaminase activity
G4235_RS05535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS05535	COG0493	'glutamate synthase
G4235_RS05540	COG2068	MobA-Related Protein
G4235_RS05545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4235_RS05550	COG3608	succinylglutamate desuccinylase aspartoacylase
G4235_RS05550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G4235_RS05555	COG0549	Belongs to the carbamate kinase family
G4235_RS05565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4235_RS05570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4235_RS05575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4235_RS05585	COG2080	2 iron, 2 sulfur cluster binding
G4235_RS05590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4235_RS05595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4235_RS05600	COG4942	peptidase
G4235_RS05610	COG0814	amino acid
G4235_RS05615	COG0183	Belongs to the thiolase family
G4235_RS05625	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS05630	COG2814	Major facilitator Superfamily
G4235_RS05635	COG1794	racemase activity, acting on amino acids and derivatives
G4235_RS05640	COG0583	DNA-binding transcription factor activity
G4235_RS05650	COG1609	Transcriptional regulator
G4235_RS05665	COG0667	Aldo Keto reductase
G4235_RS05675	COG0861	Integral membrane protein TerC family
G4235_RS05690	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
G4235_RS05705	COG2165	general secretion pathway protein
G4235_RS05710	COG4795	General secretion pathway protein
G4235_RS05720	COG4967	type IV pilus modification protein PilV
G4235_RS05725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G4235_RS05730	COG1025	Belongs to the peptidase M16 family
G4235_RS05735	COG1074	ATP-dependent DNA helicase activity
G4235_RS05740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4235_RS05745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4235_RS05745	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G4235_RS05750	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4235_RS05755	COG3711	transcriptional antiterminator
G4235_RS05760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS05760	COG1263	PTS System
G4235_RS05765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4235_RS05850	COG2885	chlorophyll binding
G4235_RS05890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G4235_RS05895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4235_RS05900	COG2166	iron-sulfur cluster assembly
G4235_RS05905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4235_RS05915	COG0583	DNA-binding transcription factor activity
G4235_RS05920	COG2363	Small membrane protein
G4235_RS05930	COG1349	DNA-binding transcription factor activity
G4235_RS05940	COG1070	Carbohydrate kinase
G4235_RS05945	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
G4235_RS05950	COG0738	Major facilitator superfamily
G4235_RS05955	COG0235	Class ii aldolase
G4235_RS05960	COG1454	alcohol dehydrogenase
G4235_RS05970	COG1760	l-serine dehydratase
G4235_RS05975	COG0814	amino acid
G4235_RS05980	COG1611	Belongs to the LOG family
G4235_RS05995	COG3098	single-species biofilm formation
G4235_RS06000	COG0564	pseudouridine synthase activity
G4235_RS06005	COG0716	FMN binding
G4235_RS06010	COG2271	Major facilitator Superfamily
G4235_RS06015	COG4948	Mandelate Racemase Muconate Lactonizing
G4235_RS06020	COG4948	Mandelate Racemase Muconate Lactonizing
G4235_RS06025	COG3850	Histidine kinase
G4235_RS06025	COG3437	response regulator, receiver
G4235_RS06025	COG2205	protein histidine kinase activity
G4235_RS06025	COG4999	Histidine kinase
G4235_RS06035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4235_RS06040	COG3956	TIGRFAM MazG family protein
G4235_RS06055	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G4235_RS06065	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G4235_RS06075	COG0602	queuosine metabolic process
G4235_RS06080	COG1070	Carbohydrate kinase
G4235_RS06085	COG2223	nitrite transmembrane transporter activity
G4235_RS06090	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS06095	COG0277	FAD linked oxidase domain protein
G4235_RS06100	COG0477	Major facilitator Superfamily
G4235_RS06105	COG2086	electron transfer activity
G4235_RS06110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4235_RS06115	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
G4235_RS06120	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G4235_RS06125	COG0644	oxidoreductase
G4235_RS06130	COG0720	synthase
G4235_RS06135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4235_RS06140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4235_RS06155	COG2234	aminopeptidase activity
G4235_RS06195	COG0585	pseudouridine synthase activity
G4235_RS06210	COG1388	LysM domain
G4235_RS06210	COG4942	peptidase
G4235_RS06215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4235_RS06230	COG2610	gluconate transmembrane transporter activity
G4235_RS06235	COG3622	Belongs to the hyi family
G4235_RS06240	COG0235	Class ii aldolase
G4235_RS06245	COG3395	kinase activity
G4235_RS06250	COG2084	Dehydrogenase
G4235_RS06255	COG1349	DNA-binding transcription factor activity
G4235_RS06260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4235_RS06265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G4235_RS06280	COG3604	Transcriptional regulator
G4235_RS06285	COG0309	Hydrogenase expression formation protein (HypE)
G4235_RS06290	COG0409	Hydrogenase expression formation protein
G4235_RS06295	COG0298	carbon dioxide binding
G4235_RS06300	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G4235_RS06305	COG0375	protein maturation
G4235_RS06315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS06320	COG0651	ATP synthesis coupled electron transport
G4235_RS06325	COG0650	Formate hydrogenlyase subunit 4
G4235_RS06330	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
G4235_RS06330	COG3261	NADH dehydrogenase
G4235_RS06335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4235_RS06340	COG3260	NADH ubiquinone oxidoreductase 20
G4235_RS06350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4235_RS06360	COG4680	protein conserved in bacteria
G4235_RS06365	COG5499	transcription regulator containing HTH domain
G4235_RS06375	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS06380	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
G4235_RS06385	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4235_RS06395	COG3604	Transcriptional regulator
G4235_RS06400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G4235_RS06400	COG0517	IMP dehydrogenase activity
G4235_RS06405	COG1349	DNA-binding transcription factor activity
G4235_RS06410	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS06415	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS06425	COG3732	PTS system glucitol sorbitol-specific
G4235_RS06430	COG3730	PTS system glucitol sorbitol-specific
G4235_RS06435	COG2951	lytic endotransglycosylase activity
G4235_RS06440	COG1546	Belongs to the CinA family
G4235_RS06460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G4235_RS06495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4235_RS06500	COG1238	metal cluster binding
G4235_RS06525	COG2814	Major facilitator Superfamily
G4235_RS06530	COG1566	PFAM secretion protein HlyD family protein
G4235_RS06535	COG1846	Transcriptional regulator
G4235_RS06550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G4235_RS06555	COG2814	Major facilitator Superfamily
G4235_RS06560	COG2113	Glycine betaine
G4235_RS06565	COG4176	ABC-type proline glycine betaine transport system permease component
G4235_RS06570	COG4175	Glycine betaine
G4235_RS06575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4235_RS06580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4235_RS06590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4235_RS06595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4235_RS06600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4235_RS06605	COG4575	ribosome binding
G4235_RS06620	COG2916	Histone family protein nucleoid-structuring protein H-NS
G4235_RS06625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4235_RS06630	COG0640	Transcriptional regulator
G4235_RS06635	COG0401	homolog of Blt101
G4235_RS06640	COG1652	LysM domain
G4235_RS06645	COG1802	Transcriptional regulator
G4235_RS06650	COG1113	amino acid transport
G4235_RS06655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4235_RS06660	COG1012	belongs to the aldehyde dehydrogenase family
G4235_RS06665	COG0579	oxidoreductase
G4235_RS06685	COG0582	viral genome integration into host DNA
G4235_RS06700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
G4235_RS06705	COG5532	Uncharacterized conserved protein (DUF2303)
G4235_RS06745	COG1846	Transcriptional regulator
G4235_RS06760	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
G4235_RS06770	COG1403	HNH endonuclease
G4235_RS06775	COG0484	heat shock protein binding
G4235_RS06785	COG1278	Cold shock
G4235_RS06790	COG1278	Cold shock
G4235_RS06810	COG3772	lysozyme
G4235_RS06820	COG1278	Cold shock
G4235_RS06850	COG4220	transposase activity
G4235_RS06870	COG1030	water channel activity
G4235_RS06920	COG1196	nuclear chromosome segregation
G4235_RS06950	COG5301	cellulose 1,4-beta-cellobiosidase activity
G4235_RS06970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4235_RS07005	COG2867	negative regulation of translational initiation
G4235_RS07015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4235_RS07020	COG0497	DNA recombination
G4235_RS07035	COG4536	flavin adenine dinucleotide binding
G4235_RS07040	COG4137	Cytochrome C assembly protein
G4235_RS07045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4235_RS07070	COG2885	chlorophyll binding
G4235_RS07075	COG2199	diguanylate cyclase activity
G4235_RS07090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4235_RS07095	COG0287	Prephenate dehydrogenase
G4235_RS07095	COG1605	Chorismate mutase
G4235_RS07100	COG0077	Prephenate dehydratase
G4235_RS07100	COG1605	Chorismate mutase
G4235_RS07110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4235_RS07115	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4235_RS07120	COG0564	pseudouridine synthase activity
G4235_RS07130	COG0542	response to heat
G4235_RS07155	COG0477	Major facilitator Superfamily
G4235_RS07160	COG5544	Lipoprotein
G4235_RS07165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4235_RS07170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4235_RS07170	COG1042	CoA-binding domain protein
G4235_RS07170	COG0045	succinate-CoA ligase (ADP-forming) activity
G4235_RS07180	COG3118	belongs to the thioredoxin family
G4235_RS07185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4235_RS07205	COG0583	DNA-binding transcription factor activity
G4235_RS07210	COG0513	Belongs to the DEAD box helicase family
G4235_RS07220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G4235_RS07230	COG1595	DNA-templated transcription, initiation
G4235_RS07235	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
G4235_RS07240	COG3026	antisigma factor binding
G4235_RS07245	COG3086	response to oxidative stress
G4235_RS07255	COG0681	Belongs to the peptidase S26 family
G4235_RS07275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G4235_RS07290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS07295	COG1737	Transcriptional regulator
G4235_RS07300	COG0560	Phosphoserine phosphatase
G4235_RS07305	COG0590	tRNA wobble adenosine to inosine editing
G4235_RS07310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G4235_RS07315	COG0047	phosphoribosylformylglycinamidine synthase activity
G4235_RS07315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4235_RS07320	COG2205	protein histidine kinase activity
G4235_RS07325	COG3170	Tfp pilus assembly protein FimV
G4235_RS07330	COG2204	response regulator
G4235_RS07335	COG0347	Belongs to the P(II) protein family
G4235_RS07340	COG1017	nitric oxide dioxygenase activity
G4235_RS07340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4235_RS07350	COG1940	carbohydrate kinase activity
G4235_RS07355	COG0457	Tetratricopeptide repeat
G4235_RS07360	COG1879	ABC-type sugar transport system periplasmic component
G4235_RS07365	COG1129	ABC transporter
G4235_RS07370	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4235_RS07375	COG1063	alcohol dehydrogenase
G4235_RS07380	COG2017	converts alpha-aldose to the beta-anomer
G4235_RS07385	COG2259	Doxx family
G4235_RS07390	COG2814	Major facilitator Superfamily
G4235_RS07395	COG3711	transcriptional antiterminator
G4235_RS07400	COG1073	alpha beta
G4235_RS07405	COG0483	inositol monophosphate 1-phosphatase activity
G4235_RS07425	COG0822	iron-sulfur transferase activity
G4235_RS07445	COG0633	Ferredoxin
G4235_RS07450	COG2975	iron-sulfur cluster assembly
G4235_RS07465	COG2897	thiosulfate sulfurtransferase activity
G4235_RS07470	COG2373	Large extracellular alpha-helical protein
G4235_RS07475	COG4953	penicillin-binding protein 1C
G4235_RS07485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4235_RS07505	COG2976	Protein conserved in bacteria
G4235_RS07520	COG1645	bacterial-type flagellum-dependent swarming motility
G4235_RS07540	COG1570	exodeoxyribonuclease VII activity
G4235_RS07545	COG0517	IMP dehydrogenase activity
G4235_RS07545	COG0516	GMP reductase activity
G4235_RS07585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4235_RS07670	COG3728	DNA packaging
G4235_RS07670	COG5484	DNA packaging
G4235_RS07775	COG3561	AntA/AntB antirepressor
G4235_RS07805	COG3179	chitinase
G4235_RS07825	COG3133	Outer membrane lipoprotein
G4235_RS07840	COG2200	EAL domain
G4235_RS07845	COG0248	Ppx GppA phosphatase
G4235_RS07850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G4235_RS07855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4235_RS07870	COG2233	PERMEase
G4235_RS07880	COG1393	Belongs to the ArsC family
G4235_RS07885	COG4783	chaperone-mediated protein folding
G4235_RS07890	COG0628	permease
G4235_RS07895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4235_RS07900	COG2716	regulation of RNA biosynthetic process
G4235_RS07910	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G4235_RS07920	COG2321	neutral zinc metallopeptidase
G4235_RS07930	COG0400	carboxylic ester hydrolase activity
G4235_RS07945	COG1393	Belongs to the ArsC family
G4235_RS07955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4235_RS07960	COG3850	Histidine kinase
G4235_RS07965	COG0493	'glutamate synthase
G4235_RS07965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS07975	COG5342	invasion associated locus B
G4235_RS07980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4235_RS07985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4235_RS07990	COG0280	phosphate acetyltransferase
G4235_RS07990	COG0281	malic enzyme
G4235_RS07995	COG4810	utilization protein
G4235_RS08000	COG4917	ethanolamine utilization protein
G4235_RS08005	COG4766	ethanolamine catabolic process
G4235_RS08010	COG4812	Cobalamin adenosyltransferase
G4235_RS08015	COG0280	phosphate acetyltransferase
G4235_RS08020	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
G4235_RS08025	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
G4235_RS08030	COG1012	belongs to the aldehyde dehydrogenase family
G4235_RS08035	COG4820	ethanolamine utilization protein (EutJ)
G4235_RS08040	COG1454	alcohol dehydrogenase
G4235_RS08045	COG3192	ethanolamine utilization protein
G4235_RS08050	COG4819	ethanolamine utilization protein
G4235_RS08055	COG4303	Ethanolamine ammonia lyase large subunit
G4235_RS08065	COG4816	utilization protein
G4235_RS08070	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
G4235_RS08075	COG2207	Transcriptional regulator
G4235_RS08085	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4235_RS08105	COG2837	iron assimilation
G4235_RS08110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS08110	COG1263	PTS System
G4235_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS08125	COG4150	thiosulfate binding
G4235_RS08130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G4235_RS08135	COG4208	sulfate ABC transporter
G4235_RS08140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G4235_RS08145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4235_RS08160	COG2190	(PTS) system
G4235_RS08165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4235_RS08170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS08175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4235_RS08185	COG3115	cell septum assembly
G4235_RS08195	COG3530	Putative quorum-sensing-regulated virulence factor
G4235_RS08200	COG0385	Bile acid
G4235_RS08205	COG0583	DNA-binding transcription factor activity
G4235_RS08215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4235_RS08220	COG2211	Major facilitator Superfamily
G4235_RS08230	COG0583	DNA-binding transcription factor activity
G4235_RS08255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4235_RS08260	COG3415	Transposase
G4235_RS08265	COG3415	Transposase
G4235_RS08280	COG2199	diguanylate cyclase activity
G4235_RS08280	COG2200	EAL domain
G4235_RS08285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4235_RS08300	COG0038	chloride channel
G4235_RS08310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS08315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS08320	COG0006	proline dipeptidase activity
G4235_RS08325	COG1363	Peptidase, m42
G4235_RS08330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4235_RS08330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS08330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS08335	COG2207	Transcriptional regulator
G4235_RS08340	COG3279	Response regulator of the LytR AlgR family
G4235_RS08345	COG3275	phosphorelay sensor kinase activity
G4235_RS08350	COG0436	Aminotransferase
G4235_RS08360	COG1560	Kdo2-lipid A biosynthetic process
G4235_RS08380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4235_RS08385	COG0028	Belongs to the TPP enzyme family
G4235_RS08390	COG0679	Auxin Efflux Carrier
G4235_RS08395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4235_RS08400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4235_RS08400	COG0784	Response regulator, receiver
G4235_RS08400	COG2198	Histidine kinase
G4235_RS08400	COG2205	protein histidine kinase activity
G4235_RS08405	COG2197	response regulator
G4235_RS08410	COG1566	PFAM secretion protein HlyD family protein
G4235_RS08415	COG0477	Major facilitator Superfamily
G4235_RS08420	COG3048	D-serine ammonia-lyase activity
G4235_RS08425	COG2610	gluconate transmembrane transporter activity
G4235_RS08430	COG0583	DNA-binding transcription factor activity
G4235_RS08435	COG0582	viral genome integration into host DNA
G4235_RS08440	COG0582	viral genome integration into host DNA
G4235_RS08465	COG2116	formate transmembrane transporter activity
G4235_RS08475	COG2067	long-chain fatty acid transport protein
G4235_RS08480	COG3691	Protein conserved in bacteria
G4235_RS08485	COG0183	Belongs to the thiolase family
G4235_RS08490	COG1024	Enoyl-CoA hydratase
G4235_RS08490	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4235_RS08495	COG2062	phosphohistidine phosphatase, SixA
G4235_RS08500	COG3539	Fimbrial protein
G4235_RS08505	COG3188	usher protein
G4235_RS08510	COG3121	Chaperone
G4235_RS08515	COG3539	Fimbrial protein
G4235_RS08520	COG3539	Fimbrial protein
G4235_RS08525	COG3539	Fimbrial protein
G4235_RS08555	COG0730	response to heat
G4235_RS08560	COG3101	peptidyl-lysine hydroxylation
G4235_RS08570	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G4235_RS08570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4235_RS08575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4235_RS08580	COG2814	Major facilitator Superfamily
G4235_RS08650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4235_RS08745	COG4695	Portal protein
G4235_RS08835	COG4974	Belongs to the 'phage' integrase family
G4235_RS08845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4235_RS08855	COG0586	Pfam SNARE associated Golgi protein
G4235_RS08865	COG0285	dihydrofolate synthase activity
G4235_RS08870	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
G4235_RS08875	COG1286	toxin biosynthetic process
G4235_RS08880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G4235_RS08885	COG0163	prenyltransferase activity
G4235_RS08890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4235_RS08895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4235_RS08900	COG4215	(ABC) transporter
G4235_RS08905	COG4160	amino acid transport
G4235_RS08910	COG4598	ABC transporter
G4235_RS08915	COG1090	epimerase
G4235_RS08920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4235_RS08925	COG0625	glutathione transferase activity
G4235_RS08930	COG0625	glutathione transferase activity
G4235_RS08935	COG0622	Phosphoesterase
G4235_RS08940	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G4235_RS08945	COG1288	antiporter activity
G4235_RS08950	COG0857	belongs to the CobB CobQ family
G4235_RS08950	COG0280	phosphate acetyltransferase
G4235_RS08955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4235_RS08960	COG3092	negative regulation of chromosome organization
G4235_RS08970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4235_RS08975	COG0471	metal ion transport
G4235_RS08975	COG0490	domain, Protein
G4235_RS08985	COG0436	Aminotransferase
G4235_RS08990	COG0583	DNA-binding transcription factor activity
G4235_RS09010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G4235_RS09015	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G4235_RS09020	COG1034	ATP synthesis coupled electron transport
G4235_RS09035	COG0839	Belongs to the complex I subunit 6 family
G4235_RS09045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4235_RS09050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4235_RS09065	COG2234	aminopeptidase activity
G4235_RS09070	COG2304	oxidoreductase activity
G4235_RS09080	COG2153	protein acetylation
G4235_RS09085	COG4575	ribosome binding
G4235_RS09090	COG1169	isochorismate synthase
G4235_RS09105	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G4235_RS09110	COG1441	menaquinone biosynthetic process
G4235_RS09115	COG0318	PFAM AMP-dependent synthetase and ligase
G4235_RS09135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4235_RS09145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4235_RS09145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4235_RS09180	COG1414	Transcriptional regulator
G4235_RS09185	COG4948	Mandelate Racemase Muconate Lactonizing
G4235_RS09190	COG2271	Major facilitator Superfamily
G4235_RS09200	COG5464	transposase or invertase
G4235_RS09205	COG0247	lactate metabolic process
G4235_RS09210	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
G4235_RS09215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4235_RS09220	COG2271	Major facilitator Superfamily
G4235_RS09225	COG0584	glycerophosphoryl diester phosphodiesterase
G4235_RS09230	COG3642	lipopolysaccharide core region biosynthetic process
G4235_RS09235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4235_RS09240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4235_RS09245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4235_RS09250	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS09255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4235_RS09260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4235_RS09265	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
G4235_RS09270	COG3234	Protein of unknown function (DUF1175)
G4235_RS09275	COG2373	Large extracellular alpha-helical protein
G4235_RS09280	COG5445	Predicted secreted protein (DUF2300)
G4235_RS09285	COG4676	Protein conserved in bacteria
G4235_RS09290	COG0183	Belongs to the thiolase family
G4235_RS09295	COG2031	fatty acid transporter
G4235_RS09300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4235_RS09305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G4235_RS09310	COG2204	response regulator
G4235_RS09315	COG3852	Histidine kinase
G4235_RS09320	COG0784	Response regulator, receiver
G4235_RS09320	COG2205	protein histidine kinase activity
G4235_RS09325	COG2197	response regulator
G4235_RS09330	COG0642	Histidine kinase
G4235_RS09330	COG2198	Histidine kinase
G4235_RS09335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G4235_RS09340	COG1477	protein flavinylation
G4235_RS09345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4235_RS09345	COG2169	Transcriptional regulator
G4235_RS09350	COG3145	DNA-N1-methyladenine dioxygenase activity
G4235_RS09355	COG4615	Cyclic peptide transporter
G4235_RS09360	COG0579	oxidoreductase
G4235_RS09370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS09370	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4235_RS09375	COG3062	negative regulation of establishment of protein localization
G4235_RS09385	COG0437	4 iron, 4 sulfur cluster binding
G4235_RS09390	COG0348	domain, Protein
G4235_RS09395	COG3043	anaerobic respiration
G4235_RS09400	COG3005	denitrification pathway
G4235_RS09405	COG4133	protoheme IX ABC transporter activity
G4235_RS09410	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4235_RS09415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4235_RS09420	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4235_RS09430	COG1138	Cytochrome C-type biogenesis protein
G4235_RS09435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4235_RS09440	COG4235	cytochrome complex assembly
G4235_RS09440	COG3088	subunit of a heme lyase
G4235_RS09445	COG2197	response regulator
G4235_RS09460	COG3083	sulfuric ester hydrolase activity
G4235_RS09480	COG1061	Type III restriction enzyme res subunit
G4235_RS09485	COG1187	pseudouridine synthase activity
G4235_RS09490	COG2814	Major facilitator Superfamily
G4235_RS09500	COG4172	Belongs to the ABC transporter superfamily
G4235_RS09505	COG4239	(ABC) transporter, permease
G4235_RS09510	COG4174	ABC transporter (Permease)
G4235_RS09515	COG4166	transmembrane transport
G4235_RS09520	COG2200	EAL domain
G4235_RS09525	COG0791	NLP P60 protein
G4235_RS09530	COG0671	phosphoesterase, PA-phosphatase related
G4235_RS09535	COG0523	cobalamin synthesis protein
G4235_RS09540	COG0246	Mannitol dehydrogenase
G4235_RS09555	COG2814	Major facilitator Superfamily
G4235_RS09560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS09560	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS09565	COG1105	Belongs to the carbohydrate kinase PfkB family
G4235_RS09570	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
G4235_RS09570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS09570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS09575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS09580	COG2313	pseudouridylate synthase activity
G4235_RS09585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4235_RS09590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4235_RS09600	COG1522	sequence-specific DNA binding
G4235_RS09600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS09610	COG2855	membrane
G4235_RS09615	COG0583	DNA-binding transcription factor activity
G4235_RS09620	COG0833	amino acid
G4235_RS09625	COG4771	TonB-dependent receptor
G4235_RS09640	COG2311	Membrane
G4235_RS09645	COG1609	Transcriptional regulator
G4235_RS09650	COG1879	ABC-type sugar transport system periplasmic component
G4235_RS09660	COG4211	Belongs to the binding-protein-dependent transport system permease family
G4235_RS09665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G4235_RS09665	COG0167	dihydroorotate dehydrogenase activity
G4235_RS09670	COG0493	'glutamate synthase
G4235_RS09680	COG2949	membrane
G4235_RS09690	COG1346	cytolysis
G4235_RS09700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4235_RS09710	COG1538	Outer membrane efflux protein
G4235_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS09720	COG0586	Pfam SNARE associated Golgi protein
G4235_RS09730	COG1686	Belongs to the peptidase S11 family
G4235_RS09735	COG0277	FAD linked oxidase domain protein
G4235_RS09740	COG1472	Belongs to the glycosyl hydrolase 3 family
G4235_RS09745	COG1732	Glycine betaine
G4235_RS09750	COG1174	glycine betaine transport
G4235_RS09755	COG1125	glycine betaine transport
G4235_RS09760	COG1174	glycine betaine transport
G4235_RS09770	COG0789	Transcriptional regulator
G4235_RS09775	COG3275	phosphorelay sensor kinase activity
G4235_RS09780	COG3279	Response regulator of the LytR AlgR family
G4235_RS09785	COG4807	Protein conserved in bacteria
G4235_RS09790	COG4808	Protein conserved in bacteria
G4235_RS09800	COG3552	Protein containing von Willebrand factor type A (VWA) domain
G4235_RS09805	COG2425	protein containing a von Willebrand factor type A (vWA) domain
G4235_RS09810	COG0714	Associated with various cellular activities
G4235_RS09820	COG3831	ATPase activity
G4235_RS09825	COG3831	ATPase activity
G4235_RS09835	COG0489	protein tyrosine kinase activity
G4235_RS09845	COG3539	Fimbrial protein
G4235_RS09850	COG3121	Chaperone
G4235_RS09855	COG3188	usher protein
G4235_RS09860	COG3539	Fimbrial protein
G4235_RS09865	COG5455	response to cobalt ion
G4235_RS09880	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
G4235_RS09885	COG0351	phosphomethylpyrimidine kinase
G4235_RS09890	COG3757	hydrolase, family 25
G4235_RS09895	COG2188	Transcriptional regulator
G4235_RS09900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS09905	COG1397	ADP-ribosylglycohydrolase
G4235_RS09910	COG2211	Major facilitator Superfamily
G4235_RS09915	COG1830	Aldolase
G4235_RS09920	COG0191	fructose-bisphosphate aldolase activity
G4235_RS09930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS09935	COG3414	Phosphotransferase system galactitol-specific IIB component
G4235_RS09940	COG3775	system Galactitol-specific IIC component
G4235_RS09945	COG1063	alcohol dehydrogenase
G4235_RS09955	COG1597	lipid kinase activity
G4235_RS09990	COG3422	double-strand break repair
G4235_RS09995	COG0745	RESPONSE REGULATOR receiver
G4235_RS10000	COG2205	protein histidine kinase activity
G4235_RS10005	COG2814	Major facilitator Superfamily
G4235_RS10010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4235_RS10020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS10035	COG4245	von Willebrand factor, type A
G4235_RS10040	COG0631	protein serine/threonine phosphatase activity
G4235_RS10045	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
G4235_RS10050	COG0443	Heat shock 70 kDa protein
G4235_RS10055	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G4235_RS10060	COG5002	protein histidine kinase activity
G4235_RS10060	COG3447	MASE1 domain protein
G4235_RS10060	COG5001	Diguanylate cyclase
G4235_RS10065	COG0572	uridine kinase
G4235_RS10075	COG2982	Protein involved in outer membrane biogenesis
G4235_RS10080	COG1253	flavin adenine dinucleotide binding
G4235_RS10090	COG1596	polysaccharide export
G4235_RS10095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4235_RS10100	COG3206	protein involved in exopolysaccharide biosynthesis
G4235_RS10100	COG0489	protein tyrosine kinase activity
G4235_RS10105	COG0463	Glycosyl transferase, family 2
G4235_RS10110	COG1045	serine acetyltransferase
G4235_RS10115	COG0438	transferase activity, transferring glycosyl groups
G4235_RS10125	COG1216	Glycosyl transferase, family 2
G4235_RS10130	COG0110	maltose O-acetyltransferase activity
G4235_RS10135	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G4235_RS10140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4235_RS10145	COG1051	belongs to the nudix hydrolase family
G4235_RS10150	COG0297	glycogen (starch) synthase activity
G4235_RS10155	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G4235_RS10155	COG0662	Cupin 2, conserved barrel domain protein
G4235_RS10160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4235_RS10165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4235_RS10170	COG2244	polysaccharide biosynthetic process
G4235_RS10175	COG2327	Polysaccharide pyruvyl transferase
G4235_RS10180	COG0438	transferase activity, transferring glycosyl groups
G4235_RS10190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4235_RS10205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G4235_RS10225	COG2244	polysaccharide biosynthetic process
G4235_RS10255	COG5433	transposase activity
G4235_RS10270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4235_RS10275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4235_RS10280	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
G4235_RS10300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4235_RS10305	COG0131	Imidazoleglycerol-phosphate dehydratase
G4235_RS10305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G4235_RS10315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4235_RS10330	COG2161	toxin-antitoxin pair type II binding
G4235_RS10335	COG4115	mRNA cleavage
G4235_RS10340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4235_RS10345	COG0583	DNA-binding transcription factor activity
G4235_RS10355	COG0531	amino acid
G4235_RS10360	COG2391	methyltransferase activity
G4235_RS10365	COG0425	Belongs to the sulfur carrier protein TusA family
G4235_RS10370	COG2925	Exonuclease
G4235_RS10375	COG1686	Belongs to the peptidase S11 family
G4235_RS10385	COG1289	transmembrane transporter activity
G4235_RS10400	COG4372	Transposase
G4235_RS10430	COG2003	Belongs to the UPF0758 family
G4235_RS10510	COG3547	Transposase (IS116 IS110 IS902 family)
G4235_RS10560	COG1735	metal-dependent hydrolase with the TIM-barrel fold
G4235_RS10575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS10595	COG1215	transferase activity, transferring glycosyl groups
G4235_RS10600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4235_RS10605	COG3969	phosphoadenosine phosphosulfate
G4235_RS10610	COG1475	DNA binding
G4235_RS10615	COG4771	TonB-dependent receptor
G4235_RS10620	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
G4235_RS10635	COG1376	ErfK ybiS ycfS ynhG family protein
G4235_RS10665	COG2197	response regulator
G4235_RS10680	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4235_RS10685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4235_RS10690	COG1960	acyl-CoA dehydrogenase activity
G4235_RS10720	COG0154	amidase activity
G4235_RS10745	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
G4235_RS10795	COG3958	Transketolase
G4235_RS10800	COG3959	Transketolase, thiamine diphosphate binding domain
G4235_RS10835	COG0582	viral genome integration into host DNA
G4235_RS10845	COG0583	DNA-binding transcription factor activity
G4235_RS10850	COG0583	DNA-binding transcription factor activity
G4235_RS10860	COG0534	Mate efflux family protein
G4235_RS10870	COG0217	transcriptional regulatory protein
G4235_RS10875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4235_RS10880	COG0477	Major facilitator Superfamily
G4235_RS10890	COG1470	cell adhesion involved in biofilm formation
G4235_RS10890	COG1388	LysM domain
G4235_RS10895	COG1388	LysM domain
G4235_RS10895	COG1470	cell adhesion involved in biofilm formation
G4235_RS10900	COG1388	LysM domain
G4235_RS10900	COG2373	Large extracellular alpha-helical protein
G4235_RS10900	COG4932	domain protein
G4235_RS10905	COG4771	TonB-dependent receptor
G4235_RS10930	COG3433	isochorismatase activity
G4235_RS10930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4235_RS10930	COG2226	methyltransferase
G4235_RS10945	COG1132	(ABC) transporter
G4235_RS10950	COG2814	Major facilitator Superfamily
G4235_RS10955	COG1169	isochorismate synthase
G4235_RS10960	COG0582	viral genome integration into host DNA
G4235_RS10980	COG3443	Belongs to the bacterial solute-binding protein 9 family
G4235_RS10995	COG2351	hydroxyisourate hydrolase activity
G4235_RS11000	COG0745	RESPONSE REGULATOR receiver
G4235_RS11005	COG2205	protein histidine kinase activity
G4235_RS11015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G4235_RS11025	COG1418	mRNA catabolic process
G4235_RS11030	COG0270	DNA (cytosine-5-)-methyltransferase activity
G4235_RS11035	COG3727	T/G mismatch-specific endonuclease activity
G4235_RS11040	COG0697	spore germination
G4235_RS11045	COG2354	Protein conserved in bacteria
G4235_RS11050	COG5475	Uncharacterized small protein (DUF2158)
G4235_RS11055	COG3706	GGDEF domain
G4235_RS11075	COG2197	response regulator
G4235_RS11080	COG1684	flagellar biosynthetic protein fliR
G4235_RS11085	COG1987	bacterial-type flagellum assembly
G4235_RS11090	COG1338	Plays a role in the flagellum-specific transport system
G4235_RS11095	COG3190	flagellar
G4235_RS11100	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4235_RS11105	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4235_RS11110	COG1580	Controls the rotational direction of flagella during chemotaxis
G4235_RS11115	COG3144	bacterial-type flagellum assembly
G4235_RS11120	COG2882	bacterial-type flagellum organization
G4235_RS11125	COG1157	protein secretion by the type III secretion system
G4235_RS11130	COG1317	bacterial-type flagellum organization
G4235_RS11135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4235_RS11140	COG1766	The M ring may be actively involved in energy transduction
G4235_RS11150	COG2076	Multidrug Resistance protein
G4235_RS11155	COG1881	PFAM PEBP family protein
G4235_RS11160	COG2207	Transcriptional regulator
G4235_RS11175	COG2135	peptidase activity
G4235_RS11180	COG0425	Belongs to the sulfur carrier protein TusA family
G4235_RS11185	COG2391	methyltransferase activity
G4235_RS11195	COG0366	Alpha amylase catalytic
G4235_RS11205	COG1516	flagellar protein fliS
G4235_RS11210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G4235_RS11220	COG1191	sigma factor activity
G4235_RS11235	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G4235_RS11250	COG2197	response regulator
G4235_RS11265	COG2197	response regulator
G4235_RS11295	COG3318	Belongs to the UPF0149 family
G4235_RS11295	COG3012	SEC-C Motif Domain Protein
G4235_RS11300	COG0814	amino acid
G4235_RS11310	COG1528	Iron-storage protein
G4235_RS11330	COG1528	Iron-storage protein
G4235_RS11335	COG1879	ABC-type sugar transport system periplasmic component
G4235_RS11340	COG1129	ABC transporter
G4235_RS11345	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4235_RS11350	COG1877	trehalose-phosphatase activity
G4235_RS11360	COG0589	response to stress
G4235_RS11375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4235_RS11380	COG1360	Flagellar Motor Protein
G4235_RS11385	COG2198	Histidine kinase
G4235_RS11385	COG0643	Histidine kinase
G4235_RS11390	COG0835	chemotaxis
G4235_RS11395	COG0840	transmembrane signaling receptor activity
G4235_RS11405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G4235_RS11415	COG0745	RESPONSE REGULATOR receiver
G4235_RS11420	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G4235_RS11425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4235_RS11430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4235_RS11445	COG3102	Protein conserved in bacteria
G4235_RS11455	COG3005	denitrification pathway
G4235_RS11475	COG3788	relative of glutathione S-transferase, MAPEG superfamily
G4235_RS11480	COG1801	Protein of unknown function DUF72
G4235_RS11485	COG1335	isochorismatase
G4235_RS11495	COG0494	nUDIX hydrolase
G4235_RS11500	COG0217	transcriptional regulatory protein
G4235_RS11530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4235_RS11540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
G4235_RS11545	COG0739	heme binding
G4235_RS11550	COG1560	Kdo2-lipid A biosynthetic process
G4235_RS11555	COG0469	pyruvate kinase activity
G4235_RS11560	COG1737	Transcriptional regulator
G4235_RS11565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4235_RS11570	COG0129	dihydroxy-acid dehydratase activity
G4235_RS11575	COG0800	Aldolase
G4235_RS11585	COG3141	response to X-ray
G4235_RS11595	COG2979	Protein of unknown function (DUF533)
G4235_RS11600	COG1770	oligopeptidase
G4235_RS11605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4235_RS11610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4235_RS11620	COG2372	response to copper ion
G4235_RS11625	COG1276	copper resistance
G4235_RS11635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4235_RS11650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4235_RS11650	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
G4235_RS11655	COG3008	intermembrane lipid transfer
G4235_RS11660	COG2995	paraquat-inducible protein a
G4235_RS11665	COG1956	GAF domain-containing protein
G4235_RS11675	COG0793	Belongs to the peptidase S41A family
G4235_RS11685	COG2814	Major facilitator Superfamily
G4235_RS11690	COG1414	Transcriptional regulator
G4235_RS11720	COG2226	methyltransferase
G4235_RS11735	COG3716	PTS system mannose fructose sorbose family IID component
G4235_RS11740	COG3715	PTS system
G4235_RS11745	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS11745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS11750	COG1253	flavin adenine dinucleotide binding
G4235_RS11755	COG2200	EAL domain
G4235_RS11760	COG1760	l-serine dehydratase
G4235_RS11765	COG0494	nUDIX hydrolase
G4235_RS11770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4235_RS11785	COG0251	oxidation-reduction process
G4235_RS11790	COG1199	ATP-dependent helicase activity
G4235_RS11795	COG1214	PFAM Peptidase M22, glycoprotease
G4235_RS11800	COG3065	identical protein binding
G4235_RS11805	COG0318	PFAM AMP-dependent synthetase and ligase
G4235_RS11810	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G4235_RS11815	COG0583	DNA-binding transcription factor activity
G4235_RS11825	COG3615	Tellurite resistance protein tehB
G4235_RS11835	COG2261	transglycosylase associated protein
G4235_RS11850	COG2199	diguanylate cyclase activity
G4235_RS11850	COG2203	Gaf domain
G4235_RS11855	COG3042	response to heat
G4235_RS11860	COG3189	MarR family transcriptional regulator
G4235_RS11865	COG2807	transmembrane transport
G4235_RS11870	COG2207	Transcriptional regulator
G4235_RS11885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4235_RS11890	COG2199	diguanylate cyclase activity
G4235_RS11895	COG2199	diguanylate cyclase activity
G4235_RS11905	COG2766	serine protein kinase
G4235_RS11910	COG3713	MltA-interacting MipA family protein
G4235_RS11915	COG0656	L-ascorbic acid biosynthetic process
G4235_RS11920	COG0676	glucose-6-phosphate 1-epimerase activity
G4235_RS11925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4235_RS11935	COG3139	Protein of unknown function (DUF1315)
G4235_RS11940	COG1063	alcohol dehydrogenase
G4235_RS11945	COG2271	Major facilitator Superfamily
G4235_RS11950	COG1063	alcohol dehydrogenase
G4235_RS11955	COG0191	fructose-bisphosphate aldolase activity
G4235_RS11960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS11965	COG0667	Aldo Keto reductase
G4235_RS11970	COG1349	DNA-binding transcription factor activity
G4235_RS11975	COG2814	Major facilitator Superfamily
G4235_RS11980	COG1335	isochorismatase
G4235_RS11985	COG0252	asparaginase activity
G4235_RS11990	COG0616	signal peptide processing
G4235_RS11995	COG0778	Nitroreductase
G4235_RS12000	COG0709	Synthesizes selenophosphate from selenide and ATP
G4235_RS12005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4235_RS12015	COG0443	Heat shock 70 kDa protein
G4235_RS12025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4235_RS12035	COG0494	nUDIX hydrolase
G4235_RS12040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4235_RS12045	COG2897	thiosulfate sulfurtransferase activity
G4235_RS12050	COG4136	ATPase activity
G4235_RS12055	COG4135	transport system, permease component
G4235_RS12060	COG4134	Bacterial extracellular solute-binding protein
G4235_RS12065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4235_RS12070	COG0398	Pfam SNARE associated Golgi protein
G4235_RS12080	COG0398	Pfam SNARE associated Golgi protein
G4235_RS12085	COG0708	Exodeoxyribonuclease III
G4235_RS12095	COG3138	arginine N-succinyltransferase
G4235_RS12105	COG3724	N-succinylarginine dihydrolase activity
G4235_RS12115	COG3678	ATP-independent chaperone mediated protein folding
G4235_RS12125	COG0322	excinuclease ABC activity
G4235_RS12135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4235_RS12140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4235_RS12145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4235_RS12150	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4235_RS12155	COG1917	Cupin 2, conserved barrel domain protein
G4235_RS12155	COG2169	Transcriptional regulator
G4235_RS12160	COG1486	melibiose metabolic process
G4235_RS12165	COG3394	polysaccharide catabolic process
G4235_RS12170	COG0753	catalase activity
G4235_RS12185	COG1988	membrane-bound metal-dependent
G4235_RS12190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4235_RS12200	COG3001	Fructosamine kinase
G4235_RS12210	COG1105	Belongs to the carbohydrate kinase PfkB family
G4235_RS12215	COG3137	Salt-induced outer membrane protein
G4235_RS12270	COG4139	cobalamin transport
G4235_RS12275	COG0386	Belongs to the glutathione peroxidase family
G4235_RS12285	COG0791	NLP P60 protein
G4235_RS12290	COG2200	EAL domain
G4235_RS12300	COG4256	Hemin uptake protein
G4235_RS12305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4235_RS12315	COG0574	Belongs to the PEP-utilizing enzyme family
G4235_RS12315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4235_RS12320	COG0318	PFAM AMP-dependent synthetase and ligase
G4235_RS12325	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G4235_RS12330	COG0644	oxidoreductase
G4235_RS12335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4235_RS12340	COG2086	electron transfer activity
G4235_RS12345	COG2207	Transcriptional regulator
G4235_RS12345	COG1917	Cupin 2, conserved barrel domain protein
G4235_RS12350	COG1960	acyl-CoA dehydrogenase activity
G4235_RS12355	COG4670	ketone body catabolic process
G4235_RS12370	COG2271	Major facilitator Superfamily
G4235_RS12375	COG0738	Major facilitator superfamily
G4235_RS12390	COG0628	permease
G4235_RS12395	COG0277	FAD linked oxidase domain protein
G4235_RS12395	COG0247	lactate metabolic process
G4235_RS12400	COG2050	protein possibly involved in aromatic compounds catabolism
G4235_RS12410	COG0316	Belongs to the HesB IscA family
G4235_RS12415	COG0719	Fe-S assembly protein
G4235_RS12420	COG0396	ATPase activity
G4235_RS12425	COG0719	Fe-S assembly protein
G4235_RS12440	COG1376	ErfK ybiS ycfS ynhG family protein
G4235_RS12445	COG4238	major outer membrane lipoprotein
G4235_RS12450	COG0469	pyruvate kinase activity
G4235_RS12460	COG0437	4 iron, 4 sulfur cluster binding
G4235_RS12465	COG2414	aldehyde ferredoxin oxidoreductase
G4235_RS12475	COG0437	4 iron, 4 sulfur cluster binding
G4235_RS12480	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
G4235_RS12510	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS12520	COG0307	riboflavin synthase, alpha
G4235_RS12525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4235_RS12530	COG2814	Major facilitator Superfamily
G4235_RS12535	COG0583	DNA-binding transcription factor activity
G4235_RS12540	COG1609	Transcriptional regulator
G4235_RS12550	COG2814	Major facilitator Superfamily
G4235_RS12555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4235_RS12560	COG0791	NLP P60 protein
G4235_RS12565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G4235_RS12570	COG1201	RNA secondary structure unwinding
G4235_RS12580	COG0346	lactoylglutathione lyase activity
G4235_RS12585	COG1902	pentaerythritol trinitrate reductase activity
G4235_RS12590	COG1309	transcriptional regulator
G4235_RS12595	COG3313	Fe-S protein
G4235_RS12600	COG4989	oxidoreductase activity
G4235_RS12605	COG2032	superoxide dismutase activity
G4235_RS12610	COG1289	transmembrane transporter activity
G4235_RS12615	COG1566	PFAM secretion protein HlyD family protein
G4235_RS12630	COG3133	Outer membrane lipoprotein
G4235_RS12640	COG3895	Periplasmic Protein
G4235_RS12655	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G4235_RS12660	COG0625	glutathione transferase activity
G4235_RS12665	COG3104	oligopeptide transport
G4235_RS12670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4235_RS12675	COG4660	Part of a membrane complex involved in electron transport
G4235_RS12680	COG4659	FMN binding
G4235_RS12685	COG4658	electron transport chain
G4235_RS12695	COG2878	Part of a membrane complex involved in electron transport
G4235_RS12720	COG0673	inositol 2-dehydrogenase activity
G4235_RS12730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4235_RS12735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS12735	COG1263	PTS System
G4235_RS12740	COG1609	Transcriptional regulator
G4235_RS12745	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS12750	COG1309	transcriptional regulator
G4235_RS12755	COG3250	beta-galactosidase activity
G4235_RS12770	COG5339	Protein conserved in bacteria
G4235_RS12775	COG1482	cell wall glycoprotein biosynthetic process
G4235_RS12780	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4235_RS12780	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G4235_RS12785	COG0114	fumarate hydratase activity
G4235_RS12795	COG2205	protein histidine kinase activity
G4235_RS12800	COG0745	RESPONSE REGULATOR receiver
G4235_RS12805	COG3136	membrane protein required for alginate biosynthesis
G4235_RS12810	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS12815	COG0531	amino acid
G4235_RS12825	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G4235_RS12830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
G4235_RS12835	COG0628	permease
G4235_RS12840	COG2076	Multidrug Resistance protein
G4235_RS12845	COG2076	Multidrug Resistance protein
G4235_RS12850	COG3591	Belongs to the peptidase S1B family
G4235_RS12865	COG2814	Major facilitator Superfamily
G4235_RS12870	COG0583	DNA-binding transcription factor activity
G4235_RS12875	COG1940	carbohydrate kinase activity
G4235_RS12880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G4235_RS12890	COG3381	protein complex oligomerization
G4235_RS12895	COG3302	dmso reductase anchor subunit
G4235_RS12905	COG0243	molybdopterin cofactor binding
G4235_RS12910	COG0243	molybdopterin cofactor binding
G4235_RS12925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4235_RS12940	COG4948	Mandelate Racemase Muconate Lactonizing
G4235_RS12945	COG1063	alcohol dehydrogenase
G4235_RS12950	COG0477	Major facilitator Superfamily
G4235_RS12955	COG0246	Mannitol dehydrogenase
G4235_RS12965	COG1802	Transcriptional regulator
G4235_RS12970	COG4221	oxidoreductase activity
G4235_RS12975	COG0339	signal peptide processing
G4235_RS12980	COG3111	PFAM Bacterial OB fold (BOF) protein
G4235_RS12995	COG2814	Major facilitator Superfamily
G4235_RS13000	COG0697	spore germination
G4235_RS13005	COG2188	Transcriptional regulator
G4235_RS13015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4235_RS13020	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4235_RS13030	COG2723	6-phospho-beta-galactosidase activity
G4235_RS13040	COG4977	sequence-specific DNA binding
G4235_RS13045	COG1846	Transcriptional regulator
G4235_RS13065	COG0583	DNA-binding transcription factor activity
G4235_RS13070	COG1012	belongs to the aldehyde dehydrogenase family
G4235_RS13075	COG2066	Belongs to the glutaminase family
G4235_RS13085	COG2199	diguanylate cyclase activity
G4235_RS13095	COG3781	membrane
G4235_RS13100	COG4106	trans-aconitate 2-methyltransferase activity
G4235_RS13105	COG1396	sequence-specific DNA binding
G4235_RS13160	COG4128	Pfam Zonular occludens toxin
G4235_RS13220	COG4128	Pfam Zonular occludens toxin
G4235_RS13245	COG0702	epimerase
G4235_RS13250	COG3539	Fimbrial protein
G4235_RS13260	COG3188	usher protein
G4235_RS13265	COG3539	Fimbrial protein
G4235_RS13270	COG3539	Fimbrial protein
G4235_RS13275	COG3539	Fimbrial protein
G4235_RS13280	COG0243	molybdopterin cofactor binding
G4235_RS13290	COG2207	Transcriptional regulator
G4235_RS13295	COG3119	arylsulfatase activity
G4235_RS13300	COG0641	radical SAM
G4235_RS13310	COG4178	(ABC) transporter
G4235_RS13315	COG4771	TonB-dependent receptor
G4235_RS13320	COG0612	Peptidase, M16
G4235_RS13325	COG0076	glutamate decarboxylase activity
G4235_RS13330	COG0531	amino acid
G4235_RS13340	COG3706	GGDEF domain
G4235_RS13340	COG3706	GGDEF domain
G4235_RS13345	COG2199	diguanylate cyclase activity
G4235_RS13345	COG2200	EAL domain
G4235_RS13345	COG2202	Pas domain
G4235_RS13350	COG1764	response to oxidative stress
G4235_RS13365	COG0281	malic enzyme
G4235_RS13370	COG1064	alcohol dehydrogenase
G4235_RS13380	COG3093	addiction module antidote protein HigA
G4235_RS13385	COG2864	formate dehydrogenase
G4235_RS13390	COG0437	4 iron, 4 sulfur cluster binding
G4235_RS13400	COG0697	spore germination
G4235_RS13405	COG2223	nitrite transmembrane transporter activity
G4235_RS13410	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G4235_RS13415	COG1140	nitrate reductase beta subunit
G4235_RS13420	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G4235_RS13425	COG2181	nitrate reductase activity
G4235_RS13430	COG0384	phenazine biosynthesis protein PhzF
G4235_RS13435	COG2162	N-hydroxyarylamine O-acetyltransferase activity
G4235_RS13440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4235_RS13470	COG3501	Rhs element vgr protein
G4235_RS13480	COG0625	glutathione transferase activity
G4235_RS13485	COG0625	glutathione transferase activity
G4235_RS13490	COG1113	amino acid transport
G4235_RS13495	COG3391	amine dehydrogenase activity
G4235_RS13500	COG4772	TonB-dependent receptor
G4235_RS13515	COG1247	-acetyltransferase
G4235_RS13520	COG3238	Protein conserved in bacteria
G4235_RS13545	COG1177	transmembrane transport
G4235_RS13550	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4235_RS13555	COG3842	ATPase activity
G4235_RS13560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4235_RS13565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4235_RS13580	COG0826	peptidase U32
G4235_RS13585	COG1396	sequence-specific DNA binding
G4235_RS13590	COG3135	benzoate transporter
G4235_RS13600	COG0500	methyltransferase
G4235_RS13605	COG1275	C4-dicarboxylate transporter malic acid transport protein
G4235_RS13610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4235_RS13615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4235_RS13620	COG2841	Protein conserved in bacteria
G4235_RS13630	COG5383	Protein conserved in bacteria
G4235_RS13635	COG0583	DNA-binding transcription factor activity
G4235_RS13655	COG3038	cytochrome b561
G4235_RS13660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4235_RS13665	COG1012	belongs to the aldehyde dehydrogenase family
G4235_RS13670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G4235_RS13675	COG1643	Atp-dependent helicase
G4235_RS13680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G4235_RS13685	COG0671	phosphoesterase, PA-phosphatase related
G4235_RS13685	COG2453	phosphatase
G4235_RS13690	COG2267	carboxylic ester hydrolase activity
G4235_RS13695	COG4589	Belongs to the CDS family
G4235_RS13700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4235_RS13715	COG3784	Protein of unknown function (DUF1318)
G4235_RS13725	COG2911	Protein conserved in bacteria
G4235_RS13730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4235_RS13735	COG3187	Heat shock protein
G4235_RS13740	COG3042	response to heat
G4235_RS13745	COG0674	pyruvate-flavodoxin oxidoreductase activity
G4235_RS13745	COG1013	pyruvate-flavodoxin oxidoreductase activity
G4235_RS13745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G4235_RS13745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4235_RS13750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G4235_RS13755	COG0589	response to stress
G4235_RS13780	COG0513	Belongs to the DEAD box helicase family
G4235_RS13795	COG4382	Mu-like prophage protein Gp16
G4235_RS13830	COG4396	Host-nuclease inhibitor protein Gam
G4235_RS13840	COG3267	Type II secretory pathway component ExeA
G4235_RS13840	COG3409	Peptidoglycan-binding domain 1 protein
G4235_RS13915	COG4373	Mu-like prophage FluMu protein gp28
G4235_RS13925	COG2369	cell adhesion
G4235_RS14045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4235_RS14050	COG3706	GGDEF domain
G4235_RS14055	COG2840	Smr protein MutS2
G4235_RS14065	COG1566	PFAM secretion protein HlyD family protein
G4235_RS14070	COG2207	Transcriptional regulator
G4235_RS14080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4235_RS14085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4235_RS14090	COG0589	response to stress
G4235_RS14095	COG3182	Iron-regulated membrane protein
G4235_RS14100	COG0668	transmembrane transport
G4235_RS14105	COG4166	transmembrane transport
G4235_RS14110	COG0583	DNA-binding transcription factor activity
G4235_RS14115	COG1073	alpha beta
G4235_RS14125	COG0702	epimerase
G4235_RS14130	COG2866	Carboxypeptidase
G4235_RS14135	COG4948	Mandelate Racemase Muconate Lactonizing
G4235_RS14140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G4235_RS14145	COG3283	Transcriptional regulator of aromatic amino acids metabolism
G4235_RS14155	COG3106	COG3106 Predicted ATPase
G4235_RS14160	COG1609	Transcriptional regulator
G4235_RS14170	COG3842	ATPase activity
G4235_RS14175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4235_RS14180	COG1554	hydrolase, family 65, central catalytic
G4235_RS14185	COG0673	inositol 2-dehydrogenase activity
G4235_RS14190	COG1082	Xylose isomerase domain protein TIM barrel
G4235_RS14195	COG1063	alcohol dehydrogenase
G4235_RS14200	COG0395	ABC-type sugar transport system, permease component
G4235_RS14205	COG1175	transmembrane transport
G4235_RS14210	COG1653	transport
G4235_RS14215	COG0366	Alpha amylase catalytic
G4235_RS14220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4235_RS14230	COG1983	PspC domain protein
G4235_RS14240	COG1842	Phage shock protein A
G4235_RS14245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G4235_RS14260	COG4166	transmembrane transport
G4235_RS14265	COG4168	peptide transport system, permease
G4235_RS14270	COG4171	peptide transport system, permease
G4235_RS14275	COG4172	Belongs to the ABC transporter superfamily
G4235_RS14280	COG4172	Belongs to the ABC transporter superfamily
G4235_RS14295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4235_RS14300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS14310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G4235_RS14315	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4235_RS14315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4235_RS14330	COG5001	Diguanylate cyclase
G4235_RS14340	COG1349	DNA-binding transcription factor activity
G4235_RS14350	COG0023	Translation Initiation Factor
G4235_RS14360	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G4235_RS14365	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
G4235_RS14370	COG0671	phosphoesterase, PA-phosphatase related
G4235_RS14380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4235_RS14400	COG0583	DNA-binding transcription factor activity
G4235_RS14405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4235_RS14415	COG0616	signal peptide processing
G4235_RS14420	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS14425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
G4235_RS14430	COG1187	pseudouridine synthase activity
G4235_RS14435	COG4907	membrane protein (DUF2207)
G4235_RS14440	COG0009	L-threonylcarbamoyladenylate synthase
G4235_RS14445	COG0613	PHP domain protein
G4235_RS14455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4235_RS14460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4235_RS14460	COG0512	Glutamine amidotransferase of anthranilate synthase
G4235_RS14465	COG0134	indole-3-glycerol-phosphate synthase activity
G4235_RS14465	COG0135	phosphoribosylanthranilate isomerase activity
G4235_RS14475	COG0159	tryptophan synthase activity
G4235_RS14480	COG3685	Protein conserved in bacteria
G4235_RS14485	COG3685	Protein conserved in bacteria
G4235_RS14490	COG3047	cAMP biosynthetic process
G4235_RS14510	COG1607	acyl-coa hydrolase
G4235_RS14520	COG2350	Protein conserved in bacteria
G4235_RS14525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4235_RS14545	COG4608	Belongs to the ABC transporter superfamily
G4235_RS14550	COG0444	Belongs to the ABC transporter superfamily
G4235_RS14555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4235_RS14560	COG0601	transmembrane transport
G4235_RS14565	COG4166	transmembrane transport
G4235_RS14575	COG2095	MarC family integral membrane protein
G4235_RS14580	COG1012	belongs to the aldehyde dehydrogenase family
G4235_RS14580	COG1454	alcohol dehydrogenase
G4235_RS14590	COG1435	thymidine kinase activity
G4235_RS14600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4235_RS14605	COG0745	RESPONSE REGULATOR receiver
G4235_RS14610	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4235_RS14620	COG0788	formyltetrahydrofolate deformylase activity
G4235_RS14665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4235_RS14670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4235_RS14675	COG2181	nitrate reductase activity
G4235_RS14680	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G4235_RS14685	COG1140	nitrate reductase beta subunit
G4235_RS14690	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G4235_RS14695	COG2223	nitrite transmembrane transporter activity
G4235_RS14700	COG3850	Histidine kinase
G4235_RS14705	COG2197	response regulator
G4235_RS14710	COG4932	domain protein
G4235_RS14715	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
G4235_RS14720	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G4235_RS14725	COG4572	Cation transport regulator
G4235_RS14730	COG0387	Pfam Sodium calcium exchanger
G4235_RS14745	COG2912	Transglutaminase-like superfamily
G4235_RS14750	COG3094	Invasion gene expression up-regulator, SirB
G4235_RS14755	COG2890	protein-(glutamine-N5) methyltransferase activity
G4235_RS14770	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G4235_RS14775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4235_RS14780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4235_RS14785	COG0659	secondary active sulfate transmembrane transporter activity
G4235_RS14800	COG0012	GTP binding
G4235_RS14810	COG3284	Transcriptional regulator
G4235_RS14815	COG2376	Dihydroxyacetone kinase
G4235_RS14820	COG1461	Dihydroxyacetone kinase
G4235_RS14825	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
G4235_RS14825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS14825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4235_RS14830	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
G4235_RS14850	COG1120	ATPase activity
G4235_RS14855	COG0500	methyltransferase
G4235_RS14860	COG0157	Belongs to the NadC ModD family
G4235_RS14875	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G4235_RS14885	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4235_RS14895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4235_RS14905	COG2719	SpoVR family
G4235_RS14915	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4235_RS14925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4235_RS14930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4235_RS14945	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4235_RS14970	COG2894	cell division
G4235_RS15050	COG2200	EAL domain
G4235_RS15055	COG0789	Transcriptional regulator
G4235_RS15060	COG5562	phage envelope protein
G4235_RS15070	COG0538	isocitrate dehydrogenase activity
G4235_RS15075	COG0456	acetyltransferase
G4235_RS15095	COG1121	(ABC) transporter
G4235_RS15100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4235_RS15105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4235_RS15120	COG5301	cellulose 1,4-beta-cellobiosidase activity
G4235_RS15150	COG1196	nuclear chromosome segregation
G4235_RS15205	COG4220	transposase activity
G4235_RS15270	COG0582	viral genome integration into host DNA
G4235_RS15285	COG1030	water channel activity
G4235_RS15305	COG4220	transposase activity
G4235_RS15330	COG3772	lysozyme
G4235_RS15475	COG0538	isocitrate dehydrogenase activity
G4235_RS15480	COG1187	pseudouridine synthase activity
G4235_RS15500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4235_RS15510	COG2205	protein histidine kinase activity
G4235_RS15515	COG2850	peptidyl-arginine hydroxylation
G4235_RS15525	COG3842	ATPase activity
G4235_RS15535	COG1177	transmembrane transport
G4235_RS15540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4235_RS15550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G4235_RS15555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4235_RS15560	COG1940	carbohydrate kinase activity
G4235_RS15565	COG4591	ABC-type transport system involved in lipoprotein release permease component
G4235_RS15575	COG4591	ABC-type transport system involved in lipoprotein release permease component
G4235_RS15580	COG4763	Acyl-transferase
G4235_RS15585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4235_RS15590	COG1388	LysM domain
G4235_RS15590	COG1376	ErfK ybiS ycfS ynhG family protein
G4235_RS15600	COG1309	transcriptional regulator
G4235_RS15605	COG3134	Outer membrane lipoprotein
G4235_RS15610	COG1252	NADH dehydrogenase
G4235_RS15620	COG1472	Belongs to the glycosyl hydrolase 3 family
G4235_RS15625	COG0510	thiamine kinase activity
G4235_RS15630	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
G4235_RS15635	COG5633	Lipoprotein
G4235_RS15640	COG0537	adenosine 5'-monophosphoramidase activity
G4235_RS15645	COG4773	Receptor
G4235_RS15650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS15650	COG1263	PTS System
G4235_RS15655	COG0084	hydrolase, TatD family'
G4235_RS15660	COG0470	DNA polymerase III
G4235_RS15665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4235_RS15670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4235_RS15675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4235_RS15680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4235_RS15690	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS15695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4235_RS15715	COG1399	metal-binding, possibly nucleic acid-binding protein
G4235_RS15720	COG0424	maF-like protein
G4235_RS15725	COG0564	pseudouridine synthase activity
G4235_RS15730	COG1530	ribonuclease E activity
G4235_RS15735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4235_RS15740	COG1256	bacterial-type flagellum assembly
G4235_RS15745	COG1705	Flagellar rod assembly protein muramidase FlgJ
G4235_RS15745	COG3951	Flagellar rod assembly protein muramidase FlgJ
G4235_RS15750	COG1706	bacterial-type flagellum-dependent cell motility
G4235_RS15760	COG4786	Flagellar basal body rod
G4235_RS15765	COG4787	bacterial-type flagellum-dependent cell motility
G4235_RS15770	COG1749	Flagellar hook protein flgE
G4235_RS15775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G4235_RS15780	COG1558	bacterial-type flagellum-dependent cell motility
G4235_RS15785	COG1815	bacterial-type flagellum-dependent cell motility
G4235_RS15790	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
G4235_RS15795	COG2747	anti-sigma28 factor FlgM
G4235_RS15800	COG3418	PFAM FlgN family protein
G4235_RS15805	COG0728	peptidoglycan biosynthetic process
G4235_RS15810	COG0673	inositol 2-dehydrogenase activity
G4235_RS15820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4235_RS15830	COG2999	glutathione oxidoreductase activity
G4235_RS15840	COG0418	dihydroorotase activity
G4235_RS15855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4235_RS15865	COG3038	cytochrome b561
G4235_RS15870	COG2353	YceI-like domain
G4235_RS15880	COG1560	Kdo2-lipid A biosynthetic process
G4235_RS15895	COG5645	(Lipo)protein
G4235_RS15900	COG2943	transferase activity, transferring hexosyl groups
G4235_RS15915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4235_RS15920	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G4235_RS15945	COG2197	response regulator
G4235_RS15960	COG1462	curli production assembly transport component CsgG
G4235_RS15970	COG3381	protein complex oligomerization
G4235_RS15980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4235_RS16025	COG2003	Belongs to the UPF0758 family
G4235_RS16050	COG2020	methyltransferase activity
G4235_RS16055	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS16100	COG0523	cobalamin synthesis protein
G4235_RS16110	COG4771	TonB-dependent receptor
G4235_RS16155	COG2382	esterase
G4235_RS16160	COG2819	hydrolase of the alpha beta superfamily
G4235_RS16165	COG4771	TonB-dependent receptor
G4235_RS16170	COG3335	DDE superfamily endonuclease
G4235_RS16210	COG3539	Fimbrial protein
G4235_RS16265	COG2994	toxin metabolic process
G4235_RS16290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4235_RS16295	COG4644	lycopene metabolic process
G4235_RS16335	COG3210	domain, Protein
G4235_RS16340	COG3210	domain, Protein
G4235_RS16370	COG0204	Acyl-transferase
G4235_RS16380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4235_RS16395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4235_RS16400	COG1216	Glycosyl transferase, family 2
G4235_RS16425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4235_RS16435	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS16440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4235_RS16460	COG2222	sugar isomerase
G4235_RS16470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4235_RS16480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G4235_RS16490	COG4983	Phage plasmid primase, P4 family domain protein
G4235_RS16515	COG0582	viral genome integration into host DNA
G4235_RS16520	COG3706	GGDEF domain
G4235_RS16525	COG0457	Tetratricopeptide repeat
G4235_RS16530	COG1649	PFAM Uncharacterised BCR, COG1649
G4235_RS16530	COG0726	polysaccharide deacetylase
G4235_RS16535	COG1215	transferase activity, transferring glycosyl groups
G4235_RS16540	COG3658	cytochrome
G4235_RS16545	COG1702	phosphate starvation-inducible protein PhoH
G4235_RS16555	COG2822	iron ion transport
G4235_RS16565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4235_RS16575	COG0506	proline dehydrogenase activity
G4235_RS16575	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G4235_RS16575	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G4235_RS16580	COG1309	transcriptional regulator
G4235_RS16585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4235_RS16590	COG1335	isochorismatase
G4235_RS16600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4235_RS16605	COG0778	Nitroreductase
G4235_RS16610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4235_RS16615	COG2233	PERMEase
G4235_RS16620	COG3729	General stress protein
G4235_RS16650	COG3381	protein complex oligomerization
G4235_RS16655	COG0243	molybdopterin cofactor binding
G4235_RS16660	COG3005	denitrification pathway
G4235_RS16665	COG0745	RESPONSE REGULATOR receiver
G4235_RS16670	COG1879	ABC-type sugar transport system periplasmic component
G4235_RS16675	COG2198	Histidine kinase
G4235_RS16675	COG0784	Response regulator, receiver
G4235_RS16675	COG2205	protein histidine kinase activity
G4235_RS16680	COG0348	domain, Protein
G4235_RS16700	COG1278	Cold shock
G4235_RS16705	COG1278	Cold shock
G4235_RS16720	COG1294	oxidase, subunit
G4235_RS16725	COG1271	oxidase subunit
G4235_RS16730	COG1773	rubredoxin
G4235_RS16735	COG1999	signal sequence binding
G4235_RS16740	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4235_RS16745	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
G4235_RS16750	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G4235_RS16755	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G4235_RS16765	COG0670	Belongs to the BI1 family
G4235_RS16770	COG2920	part of a sulfur-relay system
G4235_RS16775	COG1254	Belongs to the acylphosphatase family
G4235_RS16790	COG1832	CoA-binding protein
G4235_RS16805	COG0210	DNA helicase
G4235_RS16810	COG3304	Inner membrane component domain
G4235_RS16815	COG1289	transmembrane transporter activity
G4235_RS16820	COG3070	regulator of competence-specific genes
G4235_RS16840	COG1067	ATP-dependent peptidase activity
G4235_RS16850	COG3130	regulation of translation
G4235_RS16855	COG3009	Protein conserved in bacteria
G4235_RS16860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4235_RS16860	COG3008	intermembrane lipid transfer
G4235_RS16865	COG2995	paraquat-inducible protein a
G4235_RS16870	COG0488	(ABC) transporter
G4235_RS16875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4235_RS16875	COG0116	Belongs to the methyltransferase superfamily
G4235_RS16880	COG3217	Mosc domain protein beta barrel domain protein
G4235_RS16880	COG0633	Ferredoxin
G4235_RS16895	COG0431	NADPH-dependent FMN reductase
G4235_RS16900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4235_RS16910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4235_RS16915	COG1116	anion transmembrane transporter activity
G4235_RS16920	COG0308	aminopeptidase N
G4235_RS16940	COG1448	Aminotransferase
G4235_RS16945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4235_RS16950	COG3108	Peptidase M15
G4235_RS16955	COG2989	Protein conserved in bacteria
G4235_RS16960	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
G4235_RS16965	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
G4235_RS16975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4235_RS16980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G4235_RS16985	COG3173	Aminoglycoside phosphotransferase
G4235_RS16990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G4235_RS17000	COG3214	Protein conserved in bacteria
G4235_RS17015	COG2333	competence protein COMEC
G4235_RS17015	COG0658	competence protein
G4235_RS17025	COG0539	negative regulation of cytoplasmic translation
G4235_RS17035	COG0501	Belongs to the peptidase M48B family
G4235_RS17050	COG2323	membrane
G4235_RS17055	COG1944	ATP diphosphatase activity
G4235_RS17060	COG2116	formate transmembrane transporter activity
G4235_RS17065	COG1882	Formate acetyltransferase
G4235_RS17070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4235_RS17080	COG1335	isochorismatase
G4235_RS17085	COG3302	dmso reductase anchor subunit
G4235_RS17090	COG0437	4 iron, 4 sulfur cluster binding
G4235_RS17095	COG0243	molybdopterin cofactor binding
G4235_RS17105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4235_RS17115	COG1178	ABC-type Fe3 transport system permease component
G4235_RS17115	COG1674	ftsk spoiiie
G4235_RS17120	COG1522	sequence-specific DNA binding
G4235_RS17125	COG0492	ferredoxin-NADP+ reductase activity
G4235_RS17130	COG4988	ABC transporter
G4235_RS17135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4235_RS17155	COG0542	response to heat
G4235_RS17165	COG1278	Cold shock
G4235_RS17175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS17180	COG2990	Protein conserved in bacteria
G4235_RS17185	COG3593	DNA synthesis involved in DNA repair
G4235_RS17195	COG2431	L-lysine efflux transmembrane transporter activity
G4235_RS17200	COG1151	hydroxylamine reductase activity
G4235_RS17205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4235_RS17210	COG0028	Belongs to the TPP enzyme family
G4235_RS17215	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
G4235_RS17220	COG0702	epimerase
G4235_RS17225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4235_RS17230	COG3023	N-Acetylmuramoyl-L-alanine amidase
G4235_RS17245	COG1126	abc transporter atp-binding protein
G4235_RS17250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4235_RS17255	COG4215	(ABC) transporter
G4235_RS17260	COG4160	amino acid transport
G4235_RS17265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4235_RS17270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4235_RS17280	COG1177	transmembrane transport
G4235_RS17285	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4235_RS17290	COG3842	ATPase activity
G4235_RS17295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4235_RS17310	COG0778	Nitroreductase
G4235_RS17320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4235_RS17335	COG3226	Transcriptional regulator
G4235_RS17340	COG0738	Major facilitator superfamily
G4235_RS17345	COG0561	phosphatase activity
G4235_RS17355	COG2814	Major facilitator Superfamily
G4235_RS17360	COG0671	phosphoesterase, PA-phosphatase related
G4235_RS17365	COG1349	DNA-binding transcription factor activity
G4235_RS17370	COG1686	Belongs to the peptidase S11 family
G4235_RS17375	COG0625	glutathione transferase activity
G4235_RS17380	COG2133	pyrroloquinoline quinone binding
G4235_RS17395	COG2199	diguanylate cyclase activity
G4235_RS17400	COG2200	EAL domain
G4235_RS17420	COG4172	Belongs to the ABC transporter superfamily
G4235_RS17425	COG1446	asparaginase
G4235_RS17430	COG0303	'Molybdopterin
G4235_RS17435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4235_RS17440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4235_RS17445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4235_RS17450	COG1882	Formate acetyltransferase
G4235_RS17455	COG0561	phosphatase activity
G4235_RS17460	COG0488	(ABC) transporter
G4235_RS17465	COG1376	ErfK ybiS ycfS ynhG family protein
G4235_RS17470	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G4235_RS17475	COG1321	iron dependent repressor
G4235_RS17485	COG2194	sulfuric ester hydrolase activity
G4235_RS17490	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G4235_RS17500	COG5006	permease, DMT superfamily
G4235_RS17505	COG0783	Belongs to the Dps family
G4235_RS17510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4235_RS17515	COG0765	amino acid transport
G4235_RS17520	COG1126	abc transporter atp-binding protein
G4235_RS17525	COG0668	transmembrane transport
G4235_RS17530	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
G4235_RS17545	COG3128	pkhd-type hydroxylase
G4235_RS17550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4235_RS17560	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4235_RS17565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4235_RS17570	COG1199	ATP-dependent helicase activity
G4235_RS17580	COG0513	Belongs to the DEAD box helicase family
G4235_RS17585	COG1309	transcriptional regulator
G4235_RS17595	COG1131	(ABC) transporter
G4235_RS17600	COG0842	Transport permease protein
G4235_RS17605	COG0842	Transport permease protein
G4235_RS17615	COG3568	Endonuclease Exonuclease Phosphatase
G4235_RS17620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4235_RS17625	COG0392	lysyltransferase activity
G4235_RS17630	COG0670	Belongs to the BI1 family
G4235_RS17635	COG0670	Belongs to the BI1 family
G4235_RS17640	COG0314	molybdopterin synthase activity
G4235_RS17645	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G4235_RS17655	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4235_RS17665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4235_RS17675	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G4235_RS17680	COG2226	methyltransferase
G4235_RS17685	COG0156	8-amino-7-oxononanoate synthase activity
G4235_RS17695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4235_RS17705	COG1881	PFAM PEBP family protein
G4235_RS17710	COG4677	pectinesterase activity
G4235_RS17715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4235_RS17720	COG0471	metal ion transport
G4235_RS17725	COG2828	Protein conserved in bacteria
G4235_RS17730	COG0583	DNA-binding transcription factor activity
G4235_RS17740	COG0561	phosphatase activity
G4235_RS17745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G4235_RS17750	COG4149	molybdate abc transporter
G4235_RS17755	COG0725	ABC transporter, periplasmic molybdate-binding protein
G4235_RS17765	COG3585	molybdate ion transport
G4235_RS17765	COG2005	Transcriptional regulator
G4235_RS17770	COG1119	ATPase activity
G4235_RS17775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4235_RS17780	COG1085	galactose-1-phosphate uridylyltransferase
G4235_RS17790	COG2017	converts alpha-aldose to the beta-anomer
G4235_RS17800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4235_RS17815	COG3201	nicotinamide mononucleotide transporter
G4235_RS17820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G4235_RS17860	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
G4235_RS17865	COG2885	chlorophyll binding
G4235_RS17875	COG3064	Membrane
G4235_RS17880	COG0848	biopolymer transport protein
G4235_RS17885	COG0811	peptide transport
G4235_RS17890	COG0824	Thioesterase
G4235_RS17895	COG3790	cyd operon protein YbgE
G4235_RS17900	COG4890	Cyd operon protein YbgT
G4235_RS17905	COG1294	oxidase, subunit
G4235_RS17910	COG1271	oxidase subunit
G4235_RS17925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4235_RS17935	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4235_RS17940	COG0567	Dehydrogenase, E1 component
G4235_RS17945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4235_RS17950	COG1053	succinate dehydrogenase
G4235_RS17955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G4235_RS17960	COG2009	succinate dehydrogenase
G4235_RS17970	COG0372	Belongs to the citrate synthase family
G4235_RS17980	COG3180	Ammonia monooxygenase
G4235_RS17990	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G4235_RS17995	COG1984	allophanate hydrolase subunit 2
G4235_RS18000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G4235_RS18005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G4235_RS18015	COG0415	Belongs to the DNA photolyase family
G4235_RS18020	COG3272	Protein of unknown function (DUF1722)
G4235_RS18035	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G4235_RS18050	COG2205	protein histidine kinase activity
G4235_RS18055	COG0745	RESPONSE REGULATOR receiver
G4235_RS18065	COG1982	Orn Lys Arg decarboxylase major
G4235_RS18070	COG0531	amino acid
G4235_RS18075	COG0033	Phosphoglucomutase
G4235_RS18080	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
G4235_RS18085	COG0596	Alpha beta hydrolase
G4235_RS18095	COG0716	FMN binding
G4235_RS18105	COG0735	belongs to the Fur family
G4235_RS18125	COG1349	DNA-binding transcription factor activity
G4235_RS18130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4235_RS18135	COG3395	kinase activity
G4235_RS18140	COG1454	alcohol dehydrogenase
G4235_RS18145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4235_RS18150	COG0861	Integral membrane protein TerC family
G4235_RS18170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS18170	COG1263	PTS System
G4235_RS18170	COG2190	(PTS) system
G4235_RS18175	COG0363	glucosamine-6-phosphate deaminase activity
G4235_RS18180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4235_RS18185	COG1846	Transcriptional regulator
G4235_RS18185	COG1940	carbohydrate kinase activity
G4235_RS18190	COG0647	UMP catabolic process
G4235_RS18195	COG0367	asparagine synthase
G4235_RS18235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4235_RS18245	COG1702	phosphate starvation-inducible protein PhoH
G4235_RS18255	COG4535	Mg2 and Co2 transporter CorC
G4235_RS18260	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G4235_RS18270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4235_RS18275	COG0765	amino acid transport
G4235_RS18280	COG0765	amino acid transport
G4235_RS18285	COG1126	abc transporter atp-binding protein
G4235_RS18295	COG2888	peptidyl-tyrosine sulfation
G4235_RS18310	COG1466	dna polymerase III delta subunit
G4235_RS18320	COG0406	alpha-ribazole phosphatase activity
G4235_RS18325	COG0799	negative regulation of ribosome biogenesis
G4235_RS18335	COG0768	penicillin binding
G4235_RS18340	COG0772	Belongs to the SEDS family
G4235_RS18345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4235_RS18350	COG1686	Belongs to the peptidase S11 family
G4235_RS18375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4235_RS18380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4235_RS18400	COG3069	C4-dicarboxylate transmembrane transporter activity
G4235_RS18405	COG4565	transcriptional regulatory protein
G4235_RS18410	COG3290	protein histidine kinase activity
G4235_RS18415	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
G4235_RS18425	COG2301	Belongs to the HpcH HpaI aldolase family
G4235_RS18430	COG3051	citrate lyase alpha subunit
G4235_RS18445	COG0471	metal ion transport
G4235_RS18450	COG3719	Belongs to the RNase T2 family
G4235_RS18455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4235_RS18460	COG0589	response to stress
G4235_RS18465	COG3634	alkyl hydroperoxide reductase activity
G4235_RS18470	COG0450	alkyl hydroperoxide reductase
G4235_RS18475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4235_RS18480	COG0583	DNA-binding transcription factor activity
G4235_RS18485	COG3969	phosphoadenosine phosphosulfate
G4235_RS18490	COG1475	DNA binding
G4235_RS18495	COG0436	Aminotransferase
G4235_RS18500	COG0371	Dehydrogenase
G4235_RS18505	COG2879	small protein
G4235_RS18510	COG1966	Carbon starvation protein
G4235_RS18515	COG2050	protein possibly involved in aromatic compounds catabolism
G4235_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS18525	COG3433	isochorismatase activity
G4235_RS18525	COG1535	isochorismatase
G4235_RS18530	COG1021	2,3-dihydroxybenzoate-AMP ligase
G4235_RS18535	COG1169	isochorismate synthase
G4235_RS18540	COG4592	Periplasmic binding protein
G4235_RS18550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4235_RS18555	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4235_RS18560	COG1120	ATPase activity
G4235_RS18565	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
G4235_RS18570	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G4235_RS18570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4235_RS18575	COG3251	PFAM MbtH domain protein
G4235_RS18580	COG2382	esterase
G4235_RS18585	COG4771	TonB-dependent receptor
G4235_RS18590	COG2977	Belongs to the P-Pant transferase superfamily
G4235_RS18600	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G4235_RS18610	COG2315	Protein conserved in bacteria
G4235_RS18615	COG0778	Nitroreductase
G4235_RS18620	COG0668	transmembrane transport
G4235_RS18625	COG1113	amino acid transport
G4235_RS18630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4235_RS18635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS18640	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS18645	COG1538	Outer membrane efflux protein
G4235_RS18650	COG0745	RESPONSE REGULATOR receiver
G4235_RS18655	COG5002	protein histidine kinase activity
G4235_RS18660	COG1215	transferase activity, transferring glycosyl groups
G4235_RS18665	COG4783	chaperone-mediated protein folding
G4235_RS18675	COG4571	Outer membrane protease
G4235_RS18680	COG0500	methyltransferase
G4235_RS18685	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G4235_RS18710	COG2501	S4 domain
G4235_RS18725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4235_RS18730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4235_RS18740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G4235_RS18745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G4235_RS18750	COG0549	Belongs to the carbamate kinase family
G4235_RS18760	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4235_RS18765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4235_RS18770	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4235_RS18775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4235_RS18780	COG3257	ureidoglycine aminohydrolase activity
G4235_RS18785	COG1929	Belongs to the glycerate kinase type-1 family
G4235_RS18790	COG2233	PERMEase
G4235_RS18800	COG1953	Uracil, thiamine, allantoin
G4235_RS18805	COG2084	Dehydrogenase
G4235_RS18810	COG3622	Belongs to the hyi family
G4235_RS18815	COG3960	tartronate-semialdehyde synthase activity
G4235_RS18820	COG1414	Transcriptional regulator
G4235_RS18825	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
G4235_RS18840	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G4235_RS18845	COG4181	ATPase activity
G4235_RS18850	COG2755	lipolytic protein G-D-S-L family
G4235_RS18855	COG0300	oxidoreductase activity
G4235_RS18860	COG3118	belongs to the thioredoxin family
G4235_RS18865	COG0390	transport system, permease component
G4235_RS18870	COG4619	ABC transporter
G4235_RS18875	COG0330	HflC and HflK could
G4235_RS18880	COG1585	Membrane protein implicated in regulation of membrane protease activity
G4235_RS18890	COG0789	Transcriptional regulator
G4235_RS18895	COG0531	amino acid
G4235_RS18900	COG2066	Belongs to the glutaminase family
G4235_RS18905	COG2217	Heavy metal translocating P-type atpase
G4235_RS18910	COG3093	addiction module antidote protein HigA
G4235_RS18920	COG3735	TraB family
G4235_RS18925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4235_RS18930	COG0737	Belongs to the 5'-nucleotidase family
G4235_RS18935	COG2223	nitrite transmembrane transporter activity
G4235_RS18940	COG4651	solute:proton antiporter activity
G4235_RS18940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4235_RS18945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS18950	COG0657	acetylesterase activity
G4235_RS18980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4235_RS18990	COG2832	Protein of unknown function (DUF454)
G4235_RS18995	COG3923	Primosomal replication protein n
G4235_RS19005	COG3264	Mechanosensitive ion channel
G4235_RS19005	COG1196	nuclear chromosome segregation
G4235_RS19010	COG1309	transcriptional regulator
G4235_RS19015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4235_RS19020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4235_RS19035	COG0110	maltose O-acetyltransferase activity
G4235_RS19045	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4235_RS19050	COG5507	3-demethylubiquinone-9 3-methyltransferase
G4235_RS19060	COG3695	enzyme binding
G4235_RS19065	COG3126	Type III secretion system lipoprotein chaperone (YscW)
G4235_RS19070	COG1946	Acyl-CoA thioesterase
G4235_RS19075	COG0004	ammonium transporteR
G4235_RS19080	COG0347	Belongs to the P(II) protein family
G4235_RS19085	COG1132	(ABC) transporter
G4235_RS19090	COG1132	(ABC) transporter
G4235_RS19095	COG1522	sequence-specific DNA binding
G4235_RS19100	COG0561	phosphatase activity
G4235_RS19105	COG4533	DNA binding
G4235_RS19115	COG0824	Thioesterase
G4235_RS19120	COG1555	photosystem II stabilization
G4235_RS19125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4235_RS19130	COG0776	regulation of translation
G4235_RS19135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4235_RS19155	COG0271	Belongs to the BolA IbaG family
G4235_RS19160	COG3056	Lipoprotein
G4235_RS19165	COG2223	nitrite transmembrane transporter activity
G4235_RS19170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4235_RS19175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4235_RS19180	COG1845	cytochrome c oxidase, subunit III
G4235_RS19185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G4235_RS19195	COG2814	Major facilitator Superfamily
G4235_RS19205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G4235_RS19210	COG0693	protein deglycase activity
G4235_RS19225	COG0142	geranyltranstransferase activity
G4235_RS19235	COG0667	Aldo Keto reductase
G4235_RS19240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4235_RS19245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G4235_RS19260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4235_RS19260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4235_RS19270	COG4238	major outer membrane lipoprotein
G4235_RS19275	COG3248	Nucleoside-binding outer membrane protein
G4235_RS19280	COG1403	HNH endonuclease
G4235_RS19285	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4235_RS19290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4235_RS19295	COG1862	Preprotein translocase
G4235_RS19305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G4235_RS19310	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
G4235_RS19315	COG0366	Alpha amylase catalytic
G4235_RS19320	COG1113	amino acid transport
G4235_RS19325	COG1114	Component of the transport system for branched-chain amino acids
G4235_RS19330	COG5002	protein histidine kinase activity
G4235_RS19335	COG0745	RESPONSE REGULATOR receiver
G4235_RS19340	COG0420	3'-5' exonuclease activity
G4235_RS19345	COG0419	ATPase involved in DNA repair
G4235_RS19350	COG2814	Major facilitator Superfamily
G4235_RS19355	COG1940	carbohydrate kinase activity
G4235_RS19380	COG4126	flavin adenine dinucleotide binding
G4235_RS19400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4235_RS19405	COG3706	GGDEF domain
G4235_RS19415	COG1785	Belongs to the alkaline phosphatase family
G4235_RS19430	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4235_RS19450	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
G4235_RS19455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4235_RS19460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4235_RS19465	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS19470	COG0113	porphobilinogen synthase activity
G4235_RS19475	COG2175	clavaminate synthase activity
G4235_RS19480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4235_RS19485	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G4235_RS19490	COG4521	taurine ABC transporter
G4235_RS19495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4235_RS19500	COG1215	transferase activity, transferring glycosyl groups
G4235_RS19525	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4235_RS19530	COG3122	Protein conserved in bacteria
G4235_RS19540	COG1609	Transcriptional regulator
G4235_RS19545	COG3250	beta-galactosidase activity
G4235_RS19550	COG2223	nitrite transmembrane transporter activity
G4235_RS19555	COG0110	maltose O-acetyltransferase activity
G4235_RS19560	COG0402	S-adenosylhomocysteine deaminase activity
G4235_RS19565	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G4235_RS19570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4235_RS19575	COG2079	MmgE PrpD family protein
G4235_RS19580	COG0372	Belongs to the citrate synthase family
G4235_RS19585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G4235_RS19590	COG3829	transcription factor binding
G4235_RS19600	COG1280	lysine exporter protein (LysE YggA)
G4235_RS19610	COG1064	alcohol dehydrogenase
G4235_RS19615	COG0402	S-adenosylhomocysteine deaminase activity
G4235_RS19620	COG0549	Belongs to the carbamate kinase family
G4235_RS19630	COG1304	FMN binding
G4235_RS19635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4235_RS19645	COG0666	response to abiotic stimulus
G4235_RS19655	COG0583	DNA-binding transcription factor activity
G4235_RS19660	COG2771	luxR family
G4235_RS19660	COG2200	EAL domain
G4235_RS19665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G4235_RS19675	COG1012	belongs to the aldehyde dehydrogenase family
G4235_RS19680	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G4235_RS19685	COG0582	viral genome integration into host DNA
G4235_RS19690	COG2200	EAL domain
G4235_RS19690	COG2771	luxR family
G4235_RS19705	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS19715	COG1556	Lactate utilization protein
G4235_RS19720	COG1139	Iron-sulfur cluster binding protein
G4235_RS19725	COG0247	lactate metabolic process
G4235_RS19730	COG2207	Transcriptional regulator
G4235_RS19735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4235_RS19745	COG3059	membrane
G4235_RS19750	COG0656	L-ascorbic acid biosynthetic process
G4235_RS19755	COG3708	Transcriptional regulator
G4235_RS19755	COG2207	Transcriptional regulator
G4235_RS19760	COG1388	LysM domain
G4235_RS19765	COG0656	L-ascorbic acid biosynthetic process
G4235_RS19770	COG0667	Aldo Keto reductase
G4235_RS19780	COG0583	DNA-binding transcription factor activity
G4235_RS19785	COG1073	alpha beta
G4235_RS19790	COG1902	pentaerythritol trinitrate reductase activity
G4235_RS19830	COG3188	usher protein
G4235_RS19845	COG0727	PFAM Uncharacterised protein family (UPF0153)
G4235_RS19855	COG3477	response to acidic pH
G4235_RS19885	COG0582	viral genome integration into host DNA
G4235_RS19895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4235_RS19905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G4235_RS19925	COG2195	Cleaves the N-terminal amino acid of tripeptides
G4235_RS19930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G4235_RS19935	COG1690	Belongs to the RtcB family
G4235_RS19940	COG0454	-acetyltransferase
G4235_RS19945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4235_RS19960	COG0791	NLP P60 protein
G4235_RS19965	COG3034	peptidoglycan biosynthetic process
G4235_RS19970	COG0121	glutamine amidotransferase
G4235_RS19980	COG1960	acyl-CoA dehydrogenase activity
G4235_RS19990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4235_RS20010	COG2197	response regulator
G4235_RS20070	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS20070	COG3210	domain, Protein
G4235_RS20090	COG3210	domain, Protein
G4235_RS20095	COG3210	domain, Protein
G4235_RS20125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS20135	COG3037	sugar-specific permease SgaT UlaA
G4235_RS20150	COG0738	Major facilitator superfamily
G4235_RS20160	COG1349	DNA-binding transcription factor activity
G4235_RS20190	COG2211	Major facilitator Superfamily
G4235_RS20195	COG1917	Cupin 2, conserved barrel domain protein
G4235_RS20200	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS20205	COG0823	Involved in the tonB-independent uptake of proteins
G4235_RS20275	COG1120	ATPase activity
G4235_RS20280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4235_RS20305	COG0582	viral genome integration into host DNA
G4235_RS20370	COG4382	Mu-like prophage protein Gp16
G4235_RS20400	COG4396	Host-nuclease inhibitor protein Gam
G4235_RS20410	COG3267	Type II secretory pathway component ExeA
G4235_RS20410	COG3409	Peptidoglycan-binding domain 1 protein
G4235_RS20490	COG4373	Mu-like prophage FluMu protein gp28
G4235_RS20500	COG2369	cell adhesion
G4235_RS20625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4235_RS20645	COG2003	Belongs to the UPF0758 family
G4235_RS20685	COG3547	Transposase (IS116 IS110 IS902 family)
G4235_RS20690	COG3547	Transposase (IS116 IS110 IS902 family)
G4235_RS20695	COG3547	Transposase (IS116 IS110 IS902 family)
G4235_RS20705	COG3436	PFAM IS66 Orf2 family protein
G4235_RS20740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4235_RS20750	COG2226	methyltransferase
G4235_RS20755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4235_RS20760	COG0741	lytic transglycosylase activity
G4235_RS20760	COG1388	LysM domain
G4235_RS20765	COG2226	methyltransferase
G4235_RS20775	COG0583	DNA-binding transcription factor activity
G4235_RS20780	COG0656	L-ascorbic acid biosynthetic process
G4235_RS20815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G4235_RS20820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G4235_RS20825	COG2011	ABC-type metal ion transport system permease component
G4235_RS20830	COG1464	Belongs to the NlpA lipoprotein family
G4235_RS20840	COG1720	tRNA m6t6A37 methyltransferase activity
G4235_RS20850	COG0791	NLP P60 protein
G4235_RS20860	COG3015	lipoprotein NlpE involved in copper resistance
G4235_RS20865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G4235_RS20870	COG4681	YaeQ
G4235_RS20880	COG4568	rho-dependent transcription termination
G4235_RS20885	COG0037	tRNA processing
G4235_RS20890	COG0346	lactoylglutathione lyase activity
G4235_RS20905	COG0587	DNA-directed DNA polymerase activity
G4235_RS20910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4235_RS20930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4235_RS20935	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
G4235_RS20945	COG0750	zinc metalloprotease
G4235_RS20950	COG0575	Belongs to the CDS family
G4235_RS20955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4235_RS20960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4235_RS20985	COG0024	Methionine aminopeptidase
G4235_RS20990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G4235_RS20995	COG2171	N-acyltransferase activity
G4235_RS21005	COG3835	regulator
G4235_RS21010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4235_RS21025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4235_RS21030	COG2860	membrane
G4235_RS21055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4235_RS21060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4235_RS21065	COG1120	ATPase activity
G4235_RS21070	COG4774	siderophore transport
G4235_RS21075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4235_RS21080	COG1643	Atp-dependent helicase
G4235_RS21085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G4235_RS21095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4235_RS21100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4235_RS21105	COG0617	tRNA 3'-terminal CCA addition
G4235_RS21110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4235_RS21115	COG3539	Fimbrial protein
G4235_RS21120	COG3121	Chaperone
G4235_RS21125	COG3188	usher protein
G4235_RS21130	COG3539	Fimbrial protein
G4235_RS21135	COG3539	Fimbrial protein
G4235_RS21140	COG3539	Fimbrial protein
G4235_RS21145	COG3539	Fimbrial protein
G4235_RS21155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G4235_RS21165	COG5464	transposase or invertase
G4235_RS21175	COG0726	polysaccharide deacetylase
G4235_RS21180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS21185	COG0842	Transport permease protein
G4235_RS21190	COG1131	(ABC) transporter
G4235_RS21195	COG0288	reversible hydration of carbon dioxide
G4235_RS21200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G4235_RS21205	COG4993	Dehydrogenase
G4235_RS21210	COG2132	Multicopper oxidase
G4235_RS21235	COG1049	propionate catabolic process, 2-methylcitrate cycle
G4235_RS21240	COG3064	Membrane
G4235_RS21245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4235_RS21250	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4235_RS21255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G4235_RS21260	COG2186	Transcriptional regulator
G4235_RS21290	COG3157	Type VI secretion system effector, Hcp
G4235_RS21295	COG1113	amino acid transport
G4235_RS21300	COG3725	Membrane protein required for beta-lactamase induction
G4235_RS21305	COG3023	N-Acetylmuramoyl-L-alanine amidase
G4235_RS21310	COG0157	Belongs to the NadC ModD family
G4235_RS21315	COG4969	Belongs to the N-Me-Phe pilin family
G4235_RS21320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4235_RS21325	COG1459	type II secretion system
G4235_RS21335	COG0237	dephospho-CoA kinase activity
G4235_RS21345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G4235_RS21355	COG0494	nUDIX hydrolase
G4235_RS21375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4235_RS21380	COG0849	cell division
G4235_RS21385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4235_RS21390	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4235_RS21405	COG0772	Belongs to the SEDS family
G4235_RS21410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4235_RS21420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4235_RS21425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4235_RS21430	COG0768	penicillin binding
G4235_RS21435	COG3116	cell division
G4235_RS21440	COG0275	rRNA processing
G4235_RS21450	COG1609	Transcriptional regulator
G4235_RS21460	COG0440	acetolactate synthase activity
G4235_RS21465	COG0028	Belongs to the TPP enzyme family
G4235_RS21470	COG0583	DNA-binding transcription factor activity
G4235_RS21485	COG0473	3-isopropylmalate dehydrogenase activity
G4235_RS21510	COG4143	(ABC) transporter
G4235_RS21515	COG1178	ABC-type Fe3 transport system permease component
G4235_RS21520	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
G4235_RS21525	COG0586	Pfam SNARE associated Golgi protein
G4235_RS21540	COG4977	sequence-specific DNA binding
G4235_RS21545	COG1069	ribulokinase activity
G4235_RS21550	COG2160	L-arabinose isomerase activity
G4235_RS21555	COG0235	Class ii aldolase
G4235_RS21560	COG0417	DNA replication proofreading
G4235_RS21570	COG0564	pseudouridine synthase activity
G4235_RS21575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G4235_RS21585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4235_RS21590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4235_RS21620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4235_RS21625	COG0475	glutathione-regulated potassium exporter activity
G4235_RS21625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4235_RS21635	COG2271	Major facilitator Superfamily
G4235_RS21640	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G4235_RS21645	COG0644	oxidoreductase
G4235_RS21695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4235_RS21700	COG0505	Belongs to the CarA family
G4235_RS21725	COG1047	Peptidyl-prolyl cis-trans
G4235_RS21740	COG0196	riboflavin kinase activity
G4235_RS21755	COG0583	DNA-binding transcription factor activity
G4235_RS21770	COG3119	arylsulfatase activity
G4235_RS21800	COG4735	regulation of single-species biofilm formation
G4235_RS21805	COG1584	GPR1 FUN34 yaaH family protein
G4235_RS21810	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4235_RS21820	COG1115	amino acid carrier protein
G4235_RS21835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4235_RS21840	COG0083	homoserine kinase activity
G4235_RS21845	COG0527	aspartate kinase activity
G4235_RS21845	COG0460	homoserine dehydrogenase
G4235_RS21855	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
G4235_RS21865	COG0745	RESPONSE REGULATOR receiver
G4235_RS21870	COG4452	Inner membrane protein CreD
G4235_RS21875	COG2205	protein histidine kinase activity
G4235_RS21880	COG0745	RESPONSE REGULATOR receiver
G4235_RS21885	COG3045	CreA protein
G4235_RS21890	COG2207	Transcriptional regulator
G4235_RS21890	COG3708	Transcriptional regulator
G4235_RS21910	COG0741	lytic transglycosylase activity
G4235_RS21915	COG0488	(ABC) transporter
G4235_RS21925	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G4235_RS21930	COG1056	cytidyltransferase-related domain
G4235_RS21930	COG3172	ATPase kinase involved in NAD metabolism
G4235_RS21935	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G4235_RS21940	COG0560	Phosphoserine phosphatase
G4235_RS21945	COG3726	membrane protein affecting hemolysin expression
G4235_RS21950	COG0095	Lipoate-protein ligase
G4235_RS21955	COG3550	peptidyl-serine autophosphorylation
G4235_RS21980	COG1328	CTP reductase activity
G4235_RS21985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4235_RS21990	COG0084	hydrolase, TatD family'
G4235_RS21995	COG4667	esterase of the alpha-beta hydrolase superfamily
G4235_RS22005	COG2823	Periplasmic or secreted lipoprotein
G4235_RS22015	COG1011	Hydrolase
G4235_RS22020	COG0456	acetyltransferase
G4235_RS22025	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
G4235_RS22030	COG2813	Specifically methylates the guanine in position
G4235_RS22055	COG4114	ferric iron reductase
G4235_RS22060	COG2197	response regulator
G4235_RS22065	COG2197	response regulator
G4235_RS22070	COG2966	Psort location CytoplasmicMembrane, score
G4235_RS22085	COG1484	DNA-dependent DNA replication
G4235_RS22095	COG1368	sulfuric ester hydrolase activity
G4235_RS22100	COG1063	alcohol dehydrogenase
G4235_RS22105	COG1802	Transcriptional regulator
G4235_RS22110	COG0025	NhaP-type Na H and K H
G4235_RS22115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G4235_RS22125	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G4235_RS22130	COG0840	transmembrane signaling receptor activity
G4235_RS22135	COG1966	Carbon starvation protein
G4235_RS22140	COG2879	small protein
G4235_RS22145	COG0523	cobalamin synthesis protein
G4235_RS22165	COG0732	type I restriction modification DNA specificity domain
G4235_RS22180	COG5457	Domain of unknown function (DUF1127)
G4235_RS22190	COG2733	membrane
G4235_RS22195	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
G4235_RS22200	COG1924	4 iron, 4 sulfur cluster binding
G4235_RS22215	COG0477	Major facilitator Superfamily
G4235_RS22225	COG3366	ferrous iron transmembrane transporter activity
G4235_RS22230	COG0700	Nucleoside recognition
G4235_RS22235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4235_RS22240	COG0583	DNA-binding transcription factor activity
G4235_RS22250	COG3518	anti-sigma factor antagonist activity
G4235_RS22255	COG2186	Transcriptional regulator
G4235_RS22260	COG0246	Mannitol dehydrogenase
G4235_RS22270	COG2610	gluconate transmembrane transporter activity
G4235_RS22275	COG3539	Fimbrial protein
G4235_RS22280	COG3539	Fimbrial protein
G4235_RS22285	COG3539	Fimbrial protein
G4235_RS22290	COG3188	usher protein
G4235_RS22295	COG3121	Chaperone
G4235_RS22300	COG3539	Fimbrial protein
G4235_RS22305	COG3539	Fimbrial protein
G4235_RS22310	COG4974	Belongs to the 'phage' integrase family
G4235_RS22315	COG0582	viral genome integration into host DNA
G4235_RS22320	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G4235_RS22325	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
G4235_RS22395	COG0582	viral genome integration into host DNA
G4235_RS22405	COG1064	alcohol dehydrogenase
G4235_RS22410	COG3265	gluconokinase activity
G4235_RS22415	COG1063	alcohol dehydrogenase
G4235_RS22420	COG1028	Short-chain dehydrogenase reductase Sdr
G4235_RS22425	COG2610	gluconate transmembrane transporter activity
G4235_RS22430	COG1609	Transcriptional regulator
G4235_RS22435	COG0433	COG0433 Predicted ATPase
G4235_RS22440	COG0795	lipopolysaccharide-transporting ATPase activity
G4235_RS22445	COG0795	lipopolysaccharide-transporting ATPase activity
G4235_RS22455	COG2927	DNA polymerase III (CHI subunit)
G4235_RS22460	COG0525	valine-tRNA ligase activity
G4235_RS22470	COG0456	acetyltransferase
G4235_RS22475	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
G4235_RS22480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4235_RS22485	COG2731	YhcH YjgK YiaL family protein
G4235_RS22495	COG0549	Belongs to the carbamate kinase family
G4235_RS22500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4235_RS22505	COG1288	antiporter activity
G4235_RS22510	COG1438	arginine binding
G4235_RS22530	COG0251	oxidation-reduction process
G4235_RS22535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4235_RS22545	COG1609	Transcriptional regulator
G4235_RS22550	COG1263	PTS System
G4235_RS22550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS22555	COG0366	Alpha amylase catalytic
G4235_RS22560	COG1328	CTP reductase activity
G4235_RS22565	COG0602	queuosine metabolic process
G4235_RS22570	COG3783	Cytochrome b(562)
G4235_RS22575	COG0312	modulator of DNA gyrase
G4235_RS22580	COG3028	Belongs to the UPF0307 family
G4235_RS22585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4235_RS22595	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4235_RS22600	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4235_RS22605	COG1129	ABC transporter
G4235_RS22610	COG1879	ABC-type sugar transport system periplasmic component
G4235_RS22615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G4235_RS22620	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
G4235_RS22625	COG2105	PFAM AIG2 family protein
G4235_RS22630	COG2911	Protein conserved in bacteria
G4235_RS22635	COG0729	surface antigen
G4235_RS22640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4235_RS22645	COG1253	flavin adenine dinucleotide binding
G4235_RS22655	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
G4235_RS22660	COG1218	3'(2'),5'-bisphosphate nucleotidase
G4235_RS22665	COG0737	Belongs to the 5'-nucleotidase family
G4235_RS22670	COG1733	regulation of RNA biosynthetic process
G4235_RS22675	COG0702	epimerase
G4235_RS22680	COG0697	spore germination
G4235_RS22690	COG1113	amino acid transport
G4235_RS22695	COG0545	Peptidyl-prolyl cis-trans isomerase
G4235_RS22700	COG3061	Opacity-associated protein A
G4235_RS22705	COG1309	transcriptional regulator
G4235_RS22720	COG1024	Enoyl-CoA hydratase
G4235_RS22725	COG4670	ketone body catabolic process
G4235_RS22730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G4235_RS22735	COG2271	Major facilitator Superfamily
G4235_RS22760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4235_RS22780	COG0235	Class ii aldolase
G4235_RS22795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS22805	COG3037	sugar-specific permease SgaT UlaA
G4235_RS22820	COG1073	alpha beta
G4235_RS22825	COG3650	response to hydrogen peroxide
G4235_RS22835	COG1960	acyl-CoA dehydrogenase activity
G4235_RS22840	COG0754	glutathionylspermidine amidase activity
G4235_RS22845	COG5463	Belongs to the UPF0441 family
G4235_RS22850	COG3766	membrane
G4235_RS22860	COG1842	Phage shock protein A
G4235_RS22865	COG3789	protein conserved in bacteria
G4235_RS22870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4235_RS22875	COG0557	exoribonuclease II activity
G4235_RS22890	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
G4235_RS22895	COG0330	HflC and HflK could
G4235_RS22900	COG0330	HflC and HflK could
G4235_RS22905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4235_RS22920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4235_RS22925	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4235_RS22930	COG0802	atpase or kinase
G4235_RS22935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G4235_RS22935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4235_RS22940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4235_RS22980	COG1511	domain protein
G4235_RS22980	COG3264	Mechanosensitive ion channel
G4235_RS22985	COG0531	amino acid
G4235_RS22995	COG1053	succinate dehydrogenase
G4235_RS23000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4235_RS23015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4235_RS23020	COG3040	lipid binding
G4235_RS23025	COG2076	Multidrug Resistance protein
G4235_RS23030	COG5510	response to toxic substance
G4235_RS23035	COG5510	response to toxic substance
G4235_RS23045	COG1509	lysine 2,3-aminomutase activity
G4235_RS23070	COG0531	amino acid
G4235_RS23075	COG3030	protein affecting phage T7 exclusion by the F plasmid
G4235_RS23080	COG1027	Aspartate ammonia-lyase
G4235_RS23085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G4235_RS23095	COG4232	protein-disulfide reductase activity
G4235_RS23100	COG1309	transcriptional regulator
G4235_RS23110	COG0582	viral genome integration into host DNA
G4235_RS23120	COG2194	sulfuric ester hydrolase activity
G4235_RS23185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4235_RS23190	COG3842	ATPase activity
G4235_RS23215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G4235_RS23225	COG0583	DNA-binding transcription factor activity
G4235_RS23355	COG3468	outer membrane autotransporter barrel domain protein
G4235_RS23360	COG2020	methyltransferase activity
G4235_RS23385	COG2003	Belongs to the UPF0758 family
G4235_RS23420	COG3710	Transcriptional regulator
G4235_RS23425	COG0531	amino acid
G4235_RS23430	COG1982	Orn Lys Arg decarboxylase major
G4235_RS23435	COG3104	oligopeptide transport
G4235_RS23440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4235_RS23455	COG2388	GCN5-related N-acetyl-transferase
G4235_RS23460	COG3592	Divergent 4Fe-4S mono-cluster
G4235_RS23465	COG3290	protein histidine kinase activity
G4235_RS23470	COG4565	transcriptional regulatory protein
G4235_RS23475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G4235_RS23480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4235_RS23480	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G4235_RS23485	COG3647	Membrane
G4235_RS23490	COG1486	melibiose metabolic process
G4235_RS23495	COG2169	Transcriptional regulator
G4235_RS23500	COG1982	Orn Lys Arg decarboxylase major
G4235_RS23505	COG2207	Transcriptional regulator
G4235_RS23510	COG0531	amino acid
G4235_RS23515	COG2194	sulfuric ester hydrolase activity
G4235_RS23520	COG0745	RESPONSE REGULATOR receiver
G4235_RS23525	COG0642	Histidine kinase
G4235_RS23535	COG0477	Major facilitator Superfamily
G4235_RS23550	COG2824	Alkylphosphonate utilization operon protein PhnA
G4235_RS23565	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G4235_RS23570	COG3639	organic phosphonate transmembrane transporter activity
G4235_RS23575	COG2188	Transcriptional regulator
G4235_RS23580	COG3624	Phosphonate C-P lyase system protein PhnG
G4235_RS23585	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
G4235_RS23590	COG3626	phosphonate metabolism
G4235_RS23595	COG3627	carbon phosphorus lyase activity
G4235_RS23600	COG4107	phosphonate C-P lyase system protein PhnK
G4235_RS23605	COG4778	phosphonate C-P lyase system protein PhnL
G4235_RS23610	COG3454	Phosphonate metabolism
G4235_RS23620	COG0456	acetyltransferase
G4235_RS23625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G4235_RS23635	COG0698	ribose 5-phosphate isomerase
G4235_RS23640	COG1737	Transcriptional regulator
G4235_RS23645	COG1879	ABC-type sugar transport system periplasmic component
G4235_RS23650	COG1129	ABC transporter
G4235_RS23655	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4235_RS23660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4235_RS23665	COG1940	carbohydrate kinase activity
G4235_RS23670	COG2015	COG2015, Alkyl sulfatase and related hydrolases
G4235_RS23680	COG1566	PFAM secretion protein HlyD family protein
G4235_RS23685	COG1289	transmembrane transporter activity
G4235_RS23690	COG1538	Outer membrane efflux protein
G4235_RS23705	COG0601	transmembrane transport
G4235_RS23715	COG0444	Belongs to the ABC transporter superfamily
G4235_RS23720	COG4608	Belongs to the ABC transporter superfamily
G4235_RS23725	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
G4235_RS23730	COG1301	dicarboxylic acid transport
G4235_RS23735	COG4235	cytochrome complex assembly
G4235_RS23740	COG3088	subunit of a heme lyase
G4235_RS23745	COG1138	Cytochrome C-type biogenesis protein
G4235_RS23750	COG3301	Polysulphide reductase, NrfD
G4235_RS23755	COG0437	4 iron, 4 sulfur cluster binding
G4235_RS23760	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
G4235_RS23770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4235_RS23775	COG3162	membrane
G4235_RS23790	COG1380	Effector of murein hydrolase LrgA
G4235_RS23795	COG0583	DNA-binding transcription factor activity
G4235_RS23800	COG0025	NhaP-type Na H and K H
G4235_RS23805	COG2252	PERMEase
G4235_RS23810	COG0789	Transcriptional regulator
G4235_RS23815	COG2207	Transcriptional regulator
G4235_RS23820	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4235_RS23830	COG0629	single-stranded DNA binding
G4235_RS23835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4235_RS23840	COG2315	Protein conserved in bacteria
G4235_RS23845	COG0432	Pfam Uncharacterised protein family UPF0047
G4235_RS23850	COG3700	Belongs to the class B bacterial acid phosphatase family
G4235_RS23860	COG2204	response regulator
G4235_RS23865	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4235_RS23870	COG0471	metal ion transport
G4235_RS23875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4235_RS23880	COG0045	succinate-CoA ligase (ADP-forming) activity
G4235_RS23885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4235_RS23895	COG0567	Dehydrogenase, E1 component
G4235_RS23900	COG1448	Aminotransferase
G4235_RS23910	COG3201	nicotinamide mononucleotide transporter
G4235_RS23915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4235_RS23925	COG0305	Participates in initiation and elongation during chromosome replication
G4235_RS23930	COG1609	Transcriptional regulator
G4235_RS23940	COG1024	Enoyl-CoA hydratase
G4235_RS23945	COG0477	Major facilitator Superfamily
G4235_RS23950	COG1053	succinate dehydrogenase
G4235_RS23955	COG0604	alcohol dehydrogenase
G4235_RS23965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4235_RS23970	COG0735	belongs to the Fur family
G4235_RS23975	COG3237	CsbD-like
G4235_RS23980	COG0534	Mate efflux family protein
G4235_RS23990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G4235_RS24020	COG3842	ATPase activity
G4235_RS24025	COG2182	Extracellular solute-binding protein
G4235_RS24030	COG1175	transmembrane transport
G4235_RS24035	COG3833	ABC-type maltose transport systems, permease component
G4235_RS24050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4235_RS24075	COG0527	aspartate kinase activity
G4235_RS24085	COG1187	pseudouridine synthase activity
G4235_RS24130	COG1283	sodium-dependent phosphate transmembrane transporter activity
G4235_RS24145	COG0646	methionine synthase
G4235_RS24145	COG1410	methionine synthase
G4235_RS24150	COG1414	Transcriptional regulator
G4235_RS24160	COG2224	Isocitrate lyase
G4235_RS24165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G4235_RS24175	COG0456	acetyltransferase
G4235_RS24205	COG0138	bifunctional purine biosynthesis protein purh
G4235_RS24210	COG0151	Belongs to the GarS family
G4235_RS24215	COG2204	response regulator
G4235_RS24220	COG4191	Histidine kinase
G4235_RS24225	COG3678	ATP-independent chaperone mediated protein folding
G4235_RS24240	COG3068	Protein conserved in bacteria
G4235_RS24260	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
G4235_RS24265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G4235_RS24270	COG0352	thiamine-phosphate diphosphorylase activity
G4235_RS24275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4235_RS24280	COG2104	thiamine diphosphate biosynthetic process
G4235_RS24285	COG2022	thiamine diphosphate biosynthetic process
G4235_RS24290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4235_RS24325	COG0250	Participates in transcription elongation, termination and antitermination
G4235_RS24330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4235_RS24365	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G4235_RS24365	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G4235_RS24370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4235_RS24420	COG0477	Major facilitator Superfamily
G4235_RS24425	COG1473	amidohydrolase
G4235_RS24435	COG0583	DNA-binding transcription factor activity
G4235_RS24440	COG2271	Major facilitator Superfamily
G4235_RS24445	COG4948	Mandelate Racemase Muconate Lactonizing
G4235_RS24455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4235_RS24460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G4235_RS24475	COG2194	sulfuric ester hydrolase activity
G4235_RS24480	COG2207	Transcriptional regulator
G4235_RS24485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS24490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4235_RS24495	COG1882	Formate acetyltransferase
G4235_RS24500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS24505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4235_RS24510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS24510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4235_RS24510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4235_RS24515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4235_RS24520	COG0371	Dehydrogenase
G4235_RS24525	COG3738	Protein conserved in bacteria
G4235_RS24530	COG0697	spore germination
G4235_RS24540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G4235_RS24545	COG0737	Belongs to the 5'-nucleotidase family
G4235_RS24555	COG0737	Belongs to the 5'-nucleotidase family
G4235_RS24560	COG0737	Belongs to the 5'-nucleotidase family
G4235_RS24570	COG0460	homoserine dehydrogenase
G4235_RS24570	COG0527	aspartate kinase activity
G4235_RS24575	COG0626	cystathionine gamma-synthase activity
G4235_RS24585	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
G4235_RS24595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4235_RS24600	COG1609	Transcriptional regulator
G4235_RS24605	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4235_RS24620	COG1575	Belongs to the MenA family. Type 1 subfamily
G4235_RS24635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4235_RS24640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4235_RS24645	COG1494	fructose-1,6-bisphosphatase
G4235_RS24655	COG0589	response to stress
G4235_RS24660	COG3691	Protein conserved in bacteria
G4235_RS24665	COG3152	Membrane
G4235_RS24685	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G4235_RS24700	COG3678	ATP-independent chaperone mediated protein folding
G4235_RS24705	COG0745	RESPONSE REGULATOR receiver
G4235_RS24710	COG2205	protein histidine kinase activity
G4235_RS24715	COG2258	MOSC domain
G4235_RS24725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4235_RS24740	COG4977	sequence-specific DNA binding
G4235_RS24750	COG4806	L-rhamnose isomerase
G4235_RS24755	COG0235	Class ii aldolase
G4235_RS24775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G4235_RS24785	COG0437	4 iron, 4 sulfur cluster binding
G4235_RS24790	COG2864	formate dehydrogenase
G4235_RS24815	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G4235_RS24825	COG0456	acetyltransferase
G4235_RS24840	COG1011	Hydrolase
G4235_RS24850	COG0477	Major facilitator Superfamily
G4235_RS24860	COG1063	alcohol dehydrogenase
G4235_RS24865	COG3684	Belongs to the aldolase LacD family
G4235_RS24870	COG2084	Dehydrogenase
G4235_RS24875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS24880	COG1349	DNA-binding transcription factor activity
G4235_RS24885	COG2271	Major facilitator Superfamily
G4235_RS24890	COG1082	Xylose isomerase domain protein TIM barrel
G4235_RS24895	COG2188	Transcriptional regulator
G4235_RS24905	COG0174	glutamine synthetase
G4235_RS24910	COG3852	Histidine kinase
G4235_RS24915	COG2204	response regulator
G4235_RS24925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4235_RS24940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4235_RS24940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4235_RS24945	COG0204	Acyl-transferase
G4235_RS24950	COG5339	Protein conserved in bacteria
G4235_RS24955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4235_RS24960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4235_RS24965	COG3084	Protein conserved in bacteria
G4235_RS24970	COG0746	molybdenum cofactor guanylyltransferase activity
G4235_RS24975	COG1763	Mo-molybdopterin cofactor biosynthetic process
G4235_RS25005	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
G4235_RS25010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G4235_RS25015	COG1739	Uncharacterized protein family UPF0029
G4235_RS25025	COG1024	Enoyl-CoA hydratase
G4235_RS25025	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4235_RS25030	COG0183	Belongs to the thiolase family
G4235_RS25035	COG0543	2 iron, 2 sulfur cluster binding
G4235_RS25040	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G4235_RS25055	COG0805	protein transport
G4235_RS25065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4235_RS25075	COG3165	ubiquinone biosynthetic process from chorismate
G4235_RS25085	COG1322	Protein conserved in bacteria
G4235_RS25090	COG1414	Transcriptional regulator
G4235_RS25095	COG3734	2-keto-3-deoxy-galactonokinase
G4235_RS25100	COG0800	Aldolase
G4235_RS25120	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
G4235_RS25125	COG0412	Dienelactone hydrolase
G4235_RS25130	COG1335	isochorismatase
G4235_RS25140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4235_RS25145	COG1304	FMN binding
G4235_RS25150	COG0549	Belongs to the carbamate kinase family
G4235_RS25160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G4235_RS25165	COG0583	DNA-binding transcription factor activity
G4235_RS25170	COG1737	Transcriptional regulator
G4235_RS25175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4235_RS25180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS25180	COG2190	(PTS) system
G4235_RS25180	COG1263	PTS System
G4235_RS25190	COG3157	Type VI secretion system effector, Hcp
G4235_RS25195	COG3157	Type VI secretion system effector, Hcp
G4235_RS25205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4235_RS25210	COG0583	DNA-binding transcription factor activity
G4235_RS25215	COG0697	spore germination
G4235_RS25220	COG0561	phosphatase activity
G4235_RS25225	COG2267	carboxylic ester hydrolase activity
G4235_RS25230	COG1280	lysine exporter protein (LysE YggA)
G4235_RS25235	COG1280	lysine exporter protein (LysE YggA)
G4235_RS25240	COG0514	ATP-dependent DNA helicase (RecQ)
G4235_RS25245	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
G4235_RS25250	COG2050	protein possibly involved in aromatic compounds catabolism
G4235_RS25255	COG2962	Rard protein
G4235_RS25270	COG0598	Magnesium transport protein CorA
G4235_RS25275	COG3698	Phosphodiester glycosidase
G4235_RS25280	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
G4235_RS25285	COG0210	DNA helicase
G4235_RS25290	COG1011	Hydrolase
G4235_RS25300	COG3159	Protein conserved in bacteria
G4235_RS25305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G4235_RS25310	COG5567	small periplasmic lipoprotein
G4235_RS25325	COG1965	Belongs to the frataxin family
G4235_RS25330	COG3072	Adenylate cyclase
G4235_RS25335	COG0181	hydroxymethylbilane synthase activity
G4235_RS25340	COG1587	Uroporphyrinogen-III synthase
G4235_RS25345	COG2959	enzyme of heme biosynthesis
G4235_RS25350	COG3071	HemY protein
G4235_RS25355	COG3119	arylsulfatase activity
G4235_RS25360	COG0641	radical SAM
G4235_RS25385	COG1113	amino acid transport
G4235_RS25400	COG1819	glycosyl
G4235_RS25405	COG2244	polysaccharide biosynthetic process
G4235_RS25410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4235_RS25415	COG0456	acetyltransferase
G4235_RS25420	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G4235_RS25425	COG1088	dTDP-glucose 4,6-dehydratase activity
G4235_RS25430	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G4235_RS25435	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G4235_RS25440	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
G4235_RS25445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4235_RS25450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G4235_RS25460	COG3118	belongs to the thioredoxin family
G4235_RS25475	COG0210	DNA helicase
G4235_RS25480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4235_RS25490	COG0583	DNA-binding transcription factor activity
G4235_RS25495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4235_RS25500	COG0129	dihydroxy-acid dehydratase activity
G4235_RS25505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4235_RS25510	COG3978	acetolactate synthase activity
G4235_RS25530	COG0606	chelatase, subunit chli
G4235_RS25535	COG3085	chromosome segregation
G4235_RS25575	COG2186	Transcriptional regulator
G4235_RS25580	COG0477	Major facilitator Superfamily
G4235_RS25585	COG1609	Transcriptional regulator
G4235_RS25590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4235_RS25595	COG1879	ABC-type sugar transport system periplasmic component
G4235_RS25600	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4235_RS25605	COG1129	ABC transporter
G4235_RS25610	COG1869	D-ribose catabolic process
G4235_RS25620	COG0714	Associated with various cellular activities
G4235_RS25635	COG1522	sequence-specific DNA binding
G4235_RS25640	COG0716	FMN binding
G4235_RS25655	COG3312	ion transport
G4235_RS25700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4235_RS25705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4235_RS25710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4235_RS25715	COG0573	inorganic phosphate transmembrane transporter activity
G4235_RS25720	COG0581	inorganic phosphate transmembrane transporter activity
G4235_RS25725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4235_RS25730	COG0704	Plays a role in the regulation of phosphate uptake
G4235_RS25735	COG3711	transcriptional antiterminator
G4235_RS25740	COG1263	PTS System
G4235_RS25740	COG2190	(PTS) system
G4235_RS25740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4235_RS25745	COG2723	6-phospho-beta-galactosidase activity
G4235_RS25750	COG4580	involved in the transport of maltose and maltodextrins
G4235_RS25755	COG2382	esterase
G4235_RS25760	COG0363	glucosamine-6-phosphate deaminase activity
G4235_RS25770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4235_RS25775	COG2252	PERMEase
G4235_RS25780	COG0431	NADPH-dependent FMN reductase
G4235_RS25785	COG2091	lysine biosynthetic process via aminoadipic acid
G4235_RS25790	COG0583	DNA-binding transcription factor activity
G4235_RS25800	COG0814	amino acid
G4235_RS25805	COG3033	Beta-eliminating lyase