locus-tag class description HPE50_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPE50_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPE50_RS00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HPE50_RS00030 ENOG410667J hydrolase HPE50_RS00035 ENOG410657R replicase EC 2.7 HPE50_RS00040 ENOG4105EMF GntR family transcriptional regulator HPE50_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HPE50_RS00050 ENOG4108RTU Aldolase HPE50_RS00070 ENOG4105DJB Major Facilitator Superfamily HPE50_RS00080 ENOG4105D99 atp gtp-binding protein HPE50_RS00085 ENOG4105R2A (LipO)protein HPE50_RS00110 ENOG4105VNT transposase (IS4 family) protein HPE50_RS00125 ENOG4105C2J ABC transporter HPE50_RS00130 ENOG4105CNN ABC, transporter HPE50_RS00135 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPE50_RS00140 ENOG4108RVA ribokinase HPE50_RS00145 ENOG4105ETE Transcriptional regulator (LacI family HPE50_RS00150 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPE50_RS00155 ENOG4107EJG GntR family transcriptional regulator HPE50_RS00195 ENOG4108WFC UPF0438 protein yifE HPE50_RS00200 ENOG4105C0P Mg chelatase subunit ChlI HPE50_RS00220 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HPE50_RS00225 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPE50_RS00235 ENOG4105C7B Threonine dehydratase HPE50_RS00240 ENOG4105EMY transcriptional regulator HPE50_RS00250 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HPE50_RS00260 ENOG4105C4R Atp-dependent dna helicase HPE50_RS00285 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPE50_RS00290 ENOG4105ESV Glycosyl transferase, family 4 HPE50_RS00295 ENOG4105SFE lipopolysaccharide biosynthesis protein HPE50_RS00300 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPE50_RS00305 ENOG4107QQG Dehydrogenase HPE50_RS00310 ENOG4105C1B dTDP-glucose 4-6-dehydratase HPE50_RS00315 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HPE50_RS00320 ENOG4108WJ1 acetyltransferase HPE50_RS00325 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPE50_RS00330 ENOG4105EGZ biosynthesis protein HPE50_RS00335 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HPE50_RS00350 ENOG4105C85 amino acid HPE50_RS00375 ENOG4105C4X radical SAM domain protein HPE50_RS00380 ENOG4105ENH Sulfatase HPE50_RS00390 ENOG410601J HemY protein HPE50_RS00395 ENOG4105ECF c-methyltransferase HPE50_RS00400 ENOG41076E6 Uroporphyrinogen-III Synthase HPE50_RS00410 ENOG4107T0K Adenylate cyclase HPE50_RS00425 ENOG4105S7Z (LipO)protein HPE50_RS00435 ENOG4105CT0 Protein of unknown function, DUF484 HPE50_RS00445 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HPE50_RS00450 ENOG4105C4R Atp-dependent dna helicase HPE50_RS00455 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HPE50_RS00460 ENOG4108T58 Mg2 transport protein CorA HPE50_RS00465 ENOG4105VNT transposase (IS4 family) protein HPE50_RS00470 ENOG4108T58 Mg2 transport protein CorA HPE50_RS00475 ENOG4107QUT magnesium and cobalt transport protein CorA HPE50_RS00485 ENOG4105FR1 rard protein HPE50_RS00490 ENOG4108VUY thioesterase Superfamily protein HPE50_RS00495 ENOG4105HDD phospholipase HPE50_RS00500 ENOG4105C9U ATP-dependent DNA helicase RecQ HPE50_RS00505 ENOG4105CCF Lysine exporter protein (Lyse ygga) HPE50_RS00510 ENOG410829K Lysine exporter protein (Lyse ygga) HPE50_RS00515 ENOG4108EUD Lysophospholipase HPE50_RS00520 ENOG4105DQF Hydrolase HPE50_RS00525 ENOG4105EMK carboxylate amino acid amine transporter HPE50_RS00530 ENOG4105DZ2 Transcriptional regulator HPE50_RS00540 ENOG4105F52 Transcriptional regulator HPE50_RS00545 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HPE50_RS00555 ENOG4105C5B carbamate kinase HPE50_RS00560 ENOG4107REC cytoplasmic protein HPE50_RS00565 ENOG4107R1Q Membrane protein FdrA HPE50_RS00575 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HPE50_RS00580 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HPE50_RS00585 ENOG4108I5U Uridine phosphorylase HPE50_RS00600 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HPE50_RS00605 ENOG4108RTU Aldolase HPE50_RS00610 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HPE50_RS00615 ENOG4107HP6 Transcriptional regulator HPE50_RS00620 ENOG4105CGY Dna recombination protein HPE50_RS00630 ENOG4105JC1 sterol-binding domain protein HPE50_RS00640 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HPE50_RS00645 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HPE50_RS00650 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPE50_RS00660 ENOG4105MDZ Transcriptional activator rfaH HPE50_RS00665 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPE50_RS00670 ENOG4108EX3 reductase HPE50_RS00690 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HPE50_RS00695 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HPE50_RS00700 ENOG4108RR8 protoporphyrinogen oxidase HPE50_RS00730 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HPE50_RS00735 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HPE50_RS00740 ENOG4105PC1 Conserved Protein HPE50_RS00745 ENOG4105E27 serine threonine protein kinase HPE50_RS00750 ENOG4108Z33 Thiol disulfide Interchange Protein HPE50_RS00760 ENOG4106HNH Acyl-transferase HPE50_RS00765 ENOG4105C2M dna polymerase I HPE50_RS00780 ENOG4105D4P Coproporphyrinogen iii oxidase HPE50_RS00785 ENOG4106FIY HPE50_RS00790 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPE50_RS00795 ENOG4105CUX Signal transduction histidine kinase HPE50_RS00800 ENOG4105C5F glutamine synthetase HPE50_RS00805 ENOG4105CI3 gtp-binding protein typa HPE50_RS00810 ENOG4105E98 transcriptional regulator DeoR family HPE50_RS00815 ENOG4108MGF sugar kinase HPE50_RS00820 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPE50_RS00825 ENOG4105D2M Aldolase HPE50_RS00830 ENOG4105CPQ Dehydrogenase HPE50_RS00840 ENOG4105CSH Transporter HPE50_RS00850 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HPE50_RS00865 ENOG4105SUU thioesterase domain HPE50_RS00880 ENOG41068KX affects formate dehydrogenase-N HPE50_RS00890 ENOG4108MG3 formate dehydrogenase HPE50_RS00895 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPE50_RS00910 ENOG4108V87 frv operon regulatory protein HPE50_RS00915 ENOG4106C3V frv operon regulatory protein HPE50_RS00920 ENOG4105CN9 Peptidase m42 family protein HPE50_RS00925 ENOG4105DM4 PTS System HPE50_RS00930 ENOG41064BA PTS system, fructose-specific, IIA component HPE50_RS00965 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HPE50_RS00975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPE50_RS00985 ENOG4108RPX mosc domain containing protein HPE50_RS00990 ENOG4105E0F Histidine kinase HPE50_RS00995 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPE50_RS01000 ENOG4105FMW periplasmic HPE50_RS01015 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HPE50_RS01030 ENOG4105EBK exported protein HPE50_RS01035 ENOG4108VTS Membrane HPE50_RS01040 ENOG41065TG regulatoR HPE50_RS01050 ENOG4105DP0 ferredoxin-NADP reductase HPE50_RS01055 ENOG4105CBT Fructose-1,6-bisphosphatase HPE50_RS01065 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPE50_RS01090 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPE50_RS01105 ENOG41063M6 Cell Division Protein HPE50_RS01110 ENOG4105ETE Transcriptional regulator (LacI family HPE50_RS01115 ENOG4105C25 Primosomal protein n' HPE50_RS01125 ENOG4107S01 Repressor protein MetJ HPE50_RS01135 ENOG4105C28 cystathionine HPE50_RS01140 ENOG4105CFH Aspartokinase HPE50_RS01150 ENOG4105CGH 5'-nucleotidase HPE50_RS01155 ENOG4105SYT Methylenetetrahydrofolate reductase HPE50_RS01165 ENOG4108Q5Y Membrane HPE50_RS01170 ENOG4108XC3 NADH ubiquinone oxidoreductase HPE50_RS01175 ENOG4105DCT glycerol dehydrogenase HPE50_RS01180 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPE50_RS01185 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPE50_RS01190 ENOG4105DM4 PTS System HPE50_RS01195 ENOG4108YRF PTS System HPE50_RS01205 ENOG4108AHH pyruvate formate lyase II activase HPE50_RS01210 ENOG4108XCZ PTS System HPE50_RS01215 ENOG4106R3P AraC family transcriptional regulator HPE50_RS01220 ENOG4105DIJ Phosphoethanolamine transferase HPE50_RS01235 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPE50_RS01245 ENOG4105CH7 arginosuccinase HPE50_RS01250 ENOG4105CXK mandelate racemase muconate lactonizing HPE50_RS01255 ENOG4108I5G Major Facilitator superfamily HPE50_RS01260 ENOG4105C5Q Transcriptional regulator HPE50_RS01270 ENOG4105EJ2 Transcriptional regulator HPE50_RS01275 ENOG4108Y73 Membrane HPE50_RS01285 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HPE50_RS01315 ENOG4105D4A Cell wall formation (By similarity) HPE50_RS01320 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HPE50_RS01355 ENOG4105PM1 preprotein translocase subunit SecE HPE50_RS01360 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPE50_RS01395 ENOG4105D41 biosynthesis protein thiH HPE50_RS01405 ENOG4105WHD thiamine biosynthesis protein ThiS HPE50_RS01410 ENOG4105D06 uba thif-type nad fad binding protein HPE50_RS01445 ENOG4105R2J Conserved Protein HPE50_RS01455 ENOG4108T8B Protein of unknown function (DUF1481) HPE50_RS01460 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HPE50_RS01465 ENOG4105BZU Histidine kinase HPE50_RS01470 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPE50_RS01475 ENOG4105C12 Phosphoribosylglycinamide synthetase HPE50_RS01505 ENOG4105K5X acetyltransferase HPE50_RS01515 ENOG4107QP3 malate synthase g HPE50_RS01520 ENOG4108I9X Isocitrate lyase HPE50_RS01530 ENOG41069M3 Transcriptional regulator HPE50_RS01535 ENOG4105C3R Methionine synthase HPE50_RS01540 ENOG4105EAM Na Pi-cotransporter HPE50_RS01550 ENOG4105F9E Shikimate 5-dehydrogenase HPE50_RS01555 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HPE50_RS01560 ENOG4105F3R pts system mannose fructose sorbose family iid HPE50_RS01565 ENOG4105ETZ PTS System HPE50_RS01570 ENOG4105KPI PTS system sorbose subfamily IIB component HPE50_RS01575 ENOG4108XCU pts system HPE50_RS01580 ENOG4105CHR reductase HPE50_RS01585 ENOG4105DKT Transcriptional regulator HPE50_RS01590 ENOG4105FE9 pseudouridine synthase HPE50_RS01595 ENOG4108ZR5 Conserved Protein HPE50_RS01610 ENOG4105VNT transposase (IS4 family) protein HPE50_RS01625 ENOG4105CFH Aspartokinase HPE50_RS01640 ENOG4108MDC (LipO)protein HPE50_RS01645 ENOG4108Q9C Periplasmic Protein HPE50_RS01650 ENOG4105E3R (LipO)protein HPE50_RS01665 ENOG4105EG2 ABC transporter, permease HPE50_RS01670 ENOG4105D56 permease protein HPE50_RS01675 ENOG4107FKK extracellular solute-binding protein family 1 HPE50_RS01680 ENOG4108IJ9 (ABC) transporter HPE50_RS01690 ENOG4107W52 maltose operon periplasmic protein HPE50_RS01715 ENOG41080IJ Diacylglycerol kinase HPE50_RS01740 ENOG4105VDW Csbd family HPE50_RS01745 ENOG4105MYN Zinc uptake regulation protein HPE50_RS01755 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPE50_RS01760 ENOG4105P4Z Phage shock protein G HPE50_RS01765 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPE50_RS01770 ENOG4105CDU Replicative dna helicase HPE50_RS01775 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPE50_RS01780 ENOG4105CGF Aromatic amino acid aminotransferase HPE50_RS01790 ENOG4105F0S class B acid phosphatase HPE50_RS01795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HPE50_RS01800 ENOG4105MSB protein, conserved in bacteria HPE50_RS01805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPE50_RS01810 ENOG4108UUM single-stranded DNA-binding protein HPE50_RS01815 ENOG4108FPN Integrase HPE50_RS01845 ENOG4105PMV Membrane HPE50_RS01850 ENOG4108M8H domain protein HPE50_RS01855 ENOG4108W3Q Transcriptional regulator HPE50_RS01860 ENOG4108Z4X TRANSCRIPTIONal HPE50_RS01865 ENOG4105C7N Xanthine uracil vitamin C permease HPE50_RS01870 ENOG4105VNT transposase (IS4 family) protein HPE50_RS01875 ENOG4105EEQ Na H antiporter HPE50_RS01885 ENOG41062QD Membrane HPE50_RS01890 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPE50_RS01900 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HPE50_RS01905 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPE50_RS01910 ENOG4105DVI reductase, NrfD HPE50_RS01915 ENOG4108QKW cytochrome c-type biogenesis protein HPE50_RS01925 ENOG4108W0S formate-dependent nitrite reductase complex HPE50_RS01930 ENOG4105CK2 sodium dicarboxylate symporter HPE50_RS01935 ENOG41082ND Uncharacterized protein yjcO HPE50_RS01945 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPE50_RS01950 ENOG4108MI0 Resistance protein HPE50_RS01955 ENOG4105J12 Multidrug resistance protein mdtN HPE50_RS01960 ENOG4106833 HPE50_RS01970 ENOG4107TFG D-allose kinase HPE50_RS01975 ENOG4105UP7 3-epimerase HPE50_RS01985 ENOG4105C2J ABC transporter HPE50_RS01990 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPE50_RS01995 ENOG4105NYY transcriptional regulator, RpiR HPE50_RS02000 ENOG4108YZG isomerase HPE50_RS02010 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HPE50_RS02015 ENOG410849A acetyltransferase, (GNAT) family HPE50_RS02025 ENOG4105FD8 phosphonate metabolism protein PhnM HPE50_RS02030 ENOG4105HRV phosphonate c-p lyase system protein phnl HPE50_RS02035 ENOG4105ENV phosphonate C-P lyase system protein PhnK HPE50_RS02040 ENOG4105FT8 Phosphonate metabolism HPE50_RS02045 ENOG4105EKV Phosphonate metabolism protein HPE50_RS02050 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HPE50_RS02055 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HPE50_RS02060 ENOG4107RJJ Transcriptional regulator HPE50_RS02070 ENOG4105EHI Phosphonate ABC transporter, periplasmic HPE50_RS02075 ENOG4105D5T phosphonate abc transporter HPE50_RS02080 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HPE50_RS02085 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HPE50_RS02090 ENOG4108F5E vimentin HPE50_RS02100 ENOG4105CSH Transporter HPE50_RS02110 ENOG4105ECM Sensor protein basS pmrB HPE50_RS02115 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPE50_RS02120 ENOG4105DIJ Phosphoethanolamine transferase HPE50_RS02125 ENOG4105D5Q Arginine ornithine antiporter HPE50_RS02130 ENOG4106ZGR Transcriptional regulator HPE50_RS02135 ENOG4105CXN decarboxylase HPE50_RS02140 ENOG4108K2B transcriptional regulator HPE50_RS02145 ENOG4105F8D glycoside hydrolase family 4 HPE50_RS02150 ENOG4108R5S membrane HPE50_RS02155 ENOG4107GFK fumarate HPE50_RS02160 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPE50_RS02165 ENOG4108MRH transcriptional regulatory protein HPE50_RS02170 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPE50_RS02175 ENOG4105VR1 Pfam:DUF1271 HPE50_RS02180 ENOG410830R acetyltransferase HPE50_RS02195 ENOG4105CRK lysyL-tRNA synthetase HPE50_RS02200 ENOG4105DUX Transporter HPE50_RS02205 ENOG4105CXN decarboxylase HPE50_RS02210 ENOG4105D5Q Arginine ornithine antiporter HPE50_RS02215 ENOG4108M3R transcriptional activator CadC HPE50_RS02225 ENOG4108SIC Transcriptional regulator HPE50_RS02240 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPE50_RS02245 ENOG4108IJ0 Aspartate ammonia-lyase HPE50_RS02250 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HPE50_RS02255 ENOG4105DVH amino acid HPE50_RS02270 ENOG4108ZVF (LipO)protein HPE50_RS02275 ENOG4105MTB Uncharacterized protein YjeJ HPE50_RS02280 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPE50_RS02290 ENOG4107PEH Entericidin EcnA/B family HPE50_RS02295 ENOG4106BSU Entericidin B HPE50_RS02300 ENOG4105KPY Small multidrug resistance protein HPE50_RS02305 ENOG4105QNF Outer membrane lipoprotein HPE50_RS02310 ENOG41066YJ Beta-lactamase HPE50_RS02325 ENOG4105E33 succinate dehydrogenase HPE50_RS02330 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HPE50_RS02340 ENOG4107SC7 Inner membrane transporter yjeM HPE50_RS02345 ENOG4106V5W HPE50_RS02350 ENOG4106CG8 Inner membrane protein YjeO HPE50_RS02355 ENOG4105EGS Mechanosensitive ion channel HPE50_RS02365 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HPE50_RS02395 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HPE50_RS02400 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HPE50_RS02405 ENOG4105K8N protein family UPF0079, ATPase HPE50_RS02410 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPE50_RS02415 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HPE50_RS02430 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPE50_RS02435 ENOG4107QJR hflk protein HPE50_RS02440 ENOG4105EPW hflc protein HPE50_RS02460 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPE50_RS02465 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPE50_RS02470 ENOG4107HP6 Transcriptional regulator HPE50_RS02475 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPE50_RS02480 ENOG4105CSP Major Facilitator Superfamily HPE50_RS02485 ENOG4105CTX dehydratase HPE50_RS02495 ENOG4108P9J Phage shock protein A HPE50_RS02500 ENOG4107VNS Protein of unknown function (DUF2491) HPE50_RS02505 ENOG4105Z6B inner membrane protein yjfl HPE50_RS02510 ENOG4108KXT Conserved Protein HPE50_RS02515 ENOG4106032 Glutathionylspermidine synthase HPE50_RS02520 ENOG4105CSU acyl-Coa dehydrogenase HPE50_RS02525 ENOG4105S17 UPF0379 protein yjfN HPE50_RS02530 ENOG4105WSB biofilm stress and motility protein A HPE50_RS02535 ENOG4108MXZ Esterase HPE50_RS02550 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HPE50_RS02555 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HPE50_RS02560 ENOG4106ETB IIa component HPE50_RS02575 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPE50_RS02580 ENOG4105R3P Inner membrane protein yagU HPE50_RS02585 ENOG4105KIT UPF0379 protein yjfY HPE50_RS02600 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HPE50_RS02625 ENOG4105D7V transposase HPE50_RS02635 ENOG4105FHY Opacity-associated protein A HPE50_RS02640 ENOG4108V1T peptidylprolyl cis-trans isomerase HPE50_RS02645 ENOG4105C85 amino acid HPE50_RS02655 ENOG4105DXC membrane HPE50_RS02665 ENOG4105KVH Transcriptional regulator HPE50_RS02670 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HPE50_RS02675 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HPE50_RS02685 ENOG4108UUE Transcriptional regulator HPE50_RS02690 ENOG41061GZ Protein of unknown function (DUF1107) HPE50_RS02695 ENOG4105C37 (CBS) domain HPE50_RS02705 ENOG4105CFU surface antigen HPE50_RS02710 ENOG4105MA0 exported protein HPE50_RS02715 ENOG4108ZHD aig2 family HPE50_RS02720 ENOG4105F0N pyrophosphate phospho-hydrolase HPE50_RS02725 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HPE50_RS02730 ENOG4105C2J ABC transporter HPE50_RS02735 ENOG4107R9N ABC transporter HPE50_RS02740 ENOG41062B0 ABC transporter, permease HPE50_RS02750 ENOG4105DFU Cell wall formation (By similarity) HPE50_RS02760 ENOG4105CMS peptidase U62, modulator of DNA gyrase HPE50_RS02770 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HPE50_RS02775 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HPE50_RS02780 ENOG4105CG3 alpha amylase, catalytic region HPE50_RS02785 ENOG4105C5Y PTS System HPE50_RS02790 ENOG4105D4X repressor HPE50_RS02800 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HPE50_RS02805 ENOG4105KME endoribonuclease L-psp HPE50_RS02820 ENOG4107C93 pyrBI operon leader peptide HPE50_RS02825 ENOG4108UQ8 endoribonuclease L-psp HPE50_RS02830 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HPE50_RS02835 ENOG4108XFH Transcriptional regulator HPE50_RS02840 ENOG4105XEP YhcH YjgK YiaL family protein HPE50_RS02855 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HPE50_RS02860 ENOG4108MJ3 acetyltransferase HPE50_RS02865 ENOG4108M3P Membrane HPE50_RS02870 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPE50_RS02875 ENOG4105MYG DNA polymerase iii, chi subunit HPE50_RS02885 ENOG4108M8S permease YjgP YjgQ family protein HPE50_RS02890 ENOG4108K5H permease YjgP YjgQ family protein HPE50_RS02895 ENOG4105D7A ATP-binding protein HPE50_RS02900 ENOG4105DQ4 alcohol dehydrogenase HPE50_RS03000 ENOG4108WUH Transcriptional regulator, TetR family HPE50_RS03010 ENOG4105C94 Transporter HPE50_RS03020 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HPE50_RS03025 ENOG4108MJ5 VirK protein HPE50_RS03030 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HPE50_RS03035 ENOG4107BJW polysaccharide deacetylase HPE50_RS03050 ENOG4105E0A ABC, transporter HPE50_RS03055 ENOG4108IHU transport system permease protein HPE50_RS03060 ENOG4105DQ5 transport system permease protein HPE50_RS03065 ENOG4108HUF Transporter HPE50_RS03070 ENOG4105GAV receptor HPE50_RS03075 ENOG4108S3W Anti-feci sigma factor, fecr HPE50_RS03080 ENOG4108SF5 RNA Polymerase HPE50_RS03120 ENOG4105E5H Transposase HPE50_RS03125 ENOG4108YXQ IS66 Orf2 family protein HPE50_RS03165 ENOG4108P8R HPE50_RS03175 ENOG4105F4K antigen 43 HPE50_RS03180 ENOG4108PZQ Inner membrane protein YeeR HPE50_RS03195 ENOG4106H6R UPF0380 protein HPE50_RS03200 ENOG4106549 Antirestriction protein HPE50_RS03205 ENOG4108YGG dna repair protein HPE50_RS03215 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HPE50_RS03245 ENOG4105C0D helicase HPE50_RS03285 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HPE50_RS03295 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HPE50_RS03305 ENOG4108S54 Fimbrial protein HPE50_RS03310 ENOG4108NAE Fimbrial chaperone protein HPE50_RS03315 ENOG4105CW0 outer membrane usher protein HPE50_RS03320 ENOG4108SQA Fimbrial HPE50_RS03325 ENOG4108T65 Fimbrial HPE50_RS03330 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HPE50_RS03335 ENOG4107EFN gluconate transport system permease 3 HPE50_RS03345 ENOG4105DEI Mannitol dehydrogenase HPE50_RS03350 ENOG4105C6F GntR Family Transcriptional Regulator HPE50_RS03370 ENOG41083G8 Multidrug resistance protein MdtM HPE50_RS03375 ENOG4106BRA Membrane HPE50_RS03380 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HPE50_RS03385 ENOG4105CIZ coA-substrate-specific enzyme activase HPE50_RS03400 ENOG4105CBP Major Facilitator HPE50_RS03410 ENOG41074DU domain protein HPE50_RS03415 ENOG4108P2H Inner membrane protein YjiG HPE50_RS03420 ENOG4105DYB Isoaspartyl dipeptidase HPE50_RS03425 ENOG4107YNJ LysR family Transcriptional regulator HPE50_RS03465 ENOG4105CKI cobalamin synthesis protein HPE50_RS03470 ENOG4105VCD cytoplasmic protein HPE50_RS03475 ENOG4105D22 carbon starvation protein HPE50_RS03480 ENOG4105C8Q Methyl-accepting chemotaxis HPE50_RS03485 ENOG4108I5G Major Facilitator superfamily HPE50_RS03490 ENOG4105F2I Transposase HPE50_RS03495 ENOG4105CPQ Dehydrogenase HPE50_RS03510 ENOG4106CVF DNA replication protein HPE50_RS03525 ENOG4105DWK Membrane HPE50_RS03530 ENOG4108N8T regulatoR HPE50_RS03535 ENOG4108T94 DNA-binding transcriptional activator BglJ HPE50_RS03540 ENOG4108819 ferric iron reductase HPE50_RS03545 ENOG4105YBH Protein of unknown function (DUF1435) HPE50_RS03575 ENOG4108WPU DNA polymerase III subunit psi HPE50_RS03580 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HPE50_RS03585 ENOG4105PAD Hydrolase HPE50_RS03595 ENOG4105K3G Periplasmic Protein HPE50_RS03605 ENOG4108NRW Phospholipase, patatin family HPE50_RS03610 ENOG4105EYA deoxyribonuclease HPE50_RS03615 ENOG41076CZ activating enzyme HPE50_RS03620 ENOG4105G0K glycine radical enzyme YjjI family HPE50_RS03640 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HPE50_RS03645 ENOG4105EUP HipA domain protein HPE50_RS03655 ENOG41062Z9 Membrane HPE50_RS03660 ENOG4105EAC phosphoserine phosphatase HPE50_RS03665 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPE50_RS03670 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HPE50_RS03680 ENOG4105C5H ABC transporter HPE50_RS03685 ENOG4107SC1 transglycosylase HPE50_RS03695 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPE50_RS03705 ENOG4105UEI Transcriptional Regulator AraC Family HPE50_RS03710 ENOG4108RH0 Crea protein HPE50_RS03715 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPE50_RS03720 ENOG4105EB3 Histidine kinase HPE50_RS03725 ENOG4105CT7 inner membrane cred family protein HPE50_RS03730 ENOG41065U4 response regulator HPE50_RS03735 ENOG410759A HPE50_RS03740 ENOG4106FVC RNA methyltransferase HPE50_RS03750 ENOG4105CFH Aspartokinase HPE50_RS03760 ENOG4105D98 threonine synthase HPE50_RS03765 ENOG41062C6 Protein of unknown function (DUF2502) HPE50_RS03775 ENOG4105BZG amino acid carrier protein HPE50_RS03785 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPE50_RS03790 ENOG4105VNT transposase (IS4 family) protein HPE50_RS03795 ENOG4106HK8 GPR1 FUN34 yaaH family protein HPE50_RS03800 ENOG4108QUJ UPF0174 protein YaaW HPE50_RS03820 ENOG4105WI6 cell killing protein encoded within cryptic prophage HPE50_RS03830 ENOG41061MV Arylsulfatase HPE50_RS03845 ENOG41063Z6 transcriptional regulator, lysR family HPE50_RS03855 ENOG4105CW0 outer membrane usher protein HPE50_RS03860 ENOG4108MQF Chaperone HPE50_RS03880 ENOG410647N response to DNA damage stimulus HPE50_RS03885 ENOG4105DTN riboflavin biosynthesis protein ribF HPE50_RS03900 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HPE50_RS03920 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPE50_RS03925 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPE50_RS03930 ENOG4108XNW Transcriptional activatory protein CaiF HPE50_RS03940 ENOG4106YT9 Enoyl-CoA hydratase HPE50_RS03960 ENOG4105C94 Transporter HPE50_RS03975 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPE50_RS03980 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HPE50_RS03985 ENOG4105C54 Major Facilitator superfamily HPE50_RS04000 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HPE50_RS04035 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPE50_RS04040 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HPE50_RS04045 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HPE50_RS04050 ENOG4105D3G Pseudouridine synthase HPE50_RS04060 ENOG4105CQ2 DNA polymerase HPE50_RS04065 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPE50_RS04080 ENOG41063TF transcriptional regulator (AraC HPE50_RS04085 ENOG4108KF1 Membrane HPE50_RS04095 ENOG4106SMU thiamine transporter membrane protein HPE50_RS04100 ENOG4105DP9 ABC transporter HPE50_RS04110 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HPE50_RS04145 ENOG41064T2 transcriptional regulator, lysR family HPE50_RS04155 ENOG4105C7K acetolactate synthase HPE50_RS04160 ENOG4108ZP8 Acetolactate synthase small subunit HPE50_RS04170 ENOG4107B7Y DNA-binding transcriptional regulator FruR HPE50_RS04185 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HPE50_RS04190 ENOG4105CJN penicillin-binding protein HPE50_RS04195 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPE50_RS04200 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HPE50_RS04210 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HPE50_RS04215 ENOG4105CNI cell division protein FtsW HPE50_RS04230 ENOG4105CPF Cell wall formation (By similarity) HPE50_RS04235 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HPE50_RS04240 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPE50_RS04245 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPE50_RS04265 ENOG4105M6F mutator MutT protein HPE50_RS04280 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPE50_RS04290 ENOG4105D7Q type ii secretion system HPE50_RS04295 ENOG4107QHF type ii secretion system protein e HPE50_RS04300 ENOG4108ZUW Major pilin subunit HPE50_RS04305 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPE50_RS04310 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HPE50_RS04315 ENOG4106A72 regulatory protein AmpE HPE50_RS04320 ENOG4105C85 amino acid HPE50_RS04325 ENOG4105F2I Transposase HPE50_RS04345 ENOG41060S4 immunity protein HPE50_RS04360 ENOG41073TP transcriptional regulator HPE50_RS04365 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPE50_RS04370 ENOG4107QSN dihydrolipoamide acetyltransferase HPE50_RS04375 ENOG4107QN2 dihydrolipoyl dehydrogenase HPE50_RS04380 ENOG4108NST exported protein HPE50_RS04385 ENOG4107QIJ Aconitate hydratase 2 HPE50_RS04405 ENOG4108ZRK uncharacterized protein yacC HPE50_RS04410 ENOG4105E3B Multicopper oxidase HPE50_RS04415 ENOG4105DZG Dehydrogenase HPE50_RS04420 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPE50_RS04425 ENOG41077A9 carbonic anhydrase HPE50_RS04430 ENOG4105DA5 (ABC) transporter HPE50_RS04435 ENOG4105E3A (ABC) transporter HPE50_RS04440 ENOG4108YTN IIa component HPE50_RS04445 ENOG4107BJW polysaccharide deacetylase HPE50_RS04455 ENOG4108A32 Transposase HPE50_RS04460 ENOG4108A32 Transposase HPE50_RS04490 ENOG4105SN2 fimbrial-like adhesin protein HPE50_RS04495 ENOG4105SYG Fimbrial protein HPE50_RS04505 ENOG4105CW0 outer membrane usher protein HPE50_RS04510 ENOG4108VEV chaperone HPE50_RS04520 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPE50_RS04525 ENOG4105DJ0 Poly(A) Polymerase HPE50_RS04530 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HPE50_RS04545 ENOG4107XID 2'-5' rna ligase HPE50_RS04550 ENOG4105CQ7 ATP-dependent helicase HPE50_RS04555 ENOG4105BZ4 penicillin-binding protein HPE50_RS04560 ENOG4105E0K tonB-dependent siderophore receptor HPE50_RS04565 ENOG4105E0A ABC, transporter HPE50_RS04570 ENOG4105J76 Periplasmic binding protein HPE50_RS04575 ENOG4105S6R Iron-hydroxamate transporter permease subunit HPE50_RS04600 ENOG4105EN6 Membrane HPE50_RS04605 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HPE50_RS04620 ENOG4105C0H protease HPE50_RS04625 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HPE50_RS04645 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPE50_RS04670 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HPE50_RS04675 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HPE50_RS04680 ENOG4105KNE Phosphatidate cytidylyltransferase HPE50_RS04685 ENOG4105DZP Membrane-associated zinc metalloprotease HPE50_RS04695 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HPE50_RS04700 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPE50_RS04725 ENOG4105C0B DNA polymerase III (alpha subunit) HPE50_RS04730 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HPE50_RS04735 ENOG4105VNT transposase (IS4 family) protein HPE50_RS04740 ENOG4105CXN decarboxylase HPE50_RS04745 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HPE50_RS04750 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HPE50_RS04755 ENOG4105M1T rho-binding antiterminator HPE50_RS04765 ENOG4108VWS Yaeq family HPE50_RS04770 ENOG4108YZN class I peptide chain release factor HPE50_RS04775 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HPE50_RS04780 ENOG4108UY0 (LipO)protein HPE50_RS04790 ENOG4108R96 Methyltransferase, YaeB family HPE50_RS04795 ENOG4108R8X outer membrane lipoprotein HPE50_RS04800 ENOG4105D01 (LipO)protein HPE50_RS04805 ENOG4108UMI ABC transporter, permease HPE50_RS04810 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPE50_RS04815 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPE50_RS04865 ENOG4105HEI LysR family (Transcriptional regulator HPE50_RS04875 ENOG4105F2W methyltransferase HPE50_RS04880 ENOG4105E9H Lytic Murein transglycosylase HPE50_RS04890 ENOG4105D1A Methyltransferase HPE50_RS04900 ENOG4107RZZ dna polymerase iii epsilon subunit HPE50_RS04910 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPE50_RS04915 ENOG4108WN0 inhibitor of vertebrate lysozyme HPE50_RS04920 ENOG4107QPN acyl-Coa dehydrogenase HPE50_RS04930 ENOG4105E7A Glutamine amidotransferase HPE50_RS04935 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HPE50_RS04940 ENOG4105VXN addiction module toxin, RelE StbE family HPE50_RS04950 ENOG4108YS0 lipoprotein YafL HPE50_RS04955 ENOG4108UK5 Transposase HPE50_RS04965 ENOG4105D00 flagellar biosynthetic protein flhB HPE50_RS04970 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HPE50_RS04975 ENOG4105VS8 Flagellar biosynthetic protein fliq HPE50_RS04980 ENOG4105CN7 Flagellar biosynthetic protein FliP HPE50_RS04985 ENOG4105DD5 Flagellar motor switch protein HPE50_RS05005 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HPE50_RS05010 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPE50_RS05020 ENOG4108JIR Flagellum-specific ATP synthase HPE50_RS05030 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HPE50_RS05060 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPE50_RS05065 ENOG4108ZC9 flagellar basal-body rod protein flgc HPE50_RS05075 ENOG4105BZE flagellar hook protein, FlgE HPE50_RS05080 ENOG4108KPB Flagellar basal-body rod protein FlgF HPE50_RS05085 ENOG4105CGA flagellar basal-body rod protein FlgG HPE50_RS05100 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HPE50_RS05110 ENOG4105DTJ flagellar hook-associated protein HPE50_RS05125 ENOG4105I03 Flagellin HPE50_RS05130 ENOG410804A Flagellar hook-associated 2 domain-containing protein HPE50_RS05160 ENOG4107RD7 Flagellar Motor Protein, MotA HPE50_RS05175 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HPE50_RS05180 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome HPE50_RS05185 ENOG4108HYG acetyltransferase HPE50_RS05195 ENOG4108S2Y peptide Chain Release factor HPE50_RS05200 ENOG4105CIN aminoacyl-histidine dipeptidase HPE50_RS05210 ENOG4105V1F Fermentation respiration switch protein HPE50_RS05220 ENOG4105FCK Membrane HPE50_RS05240 ENOG4105DFP Integrase HPE50_RS05365 ENOG4106PYX Receptor HPE50_RS05375 ENOG4105PI0 Ferredoxin HPE50_RS05380 ENOG4105R3P Inner membrane protein yagU HPE50_RS05450 ENOG4105EQ2 LysR family Transcriptional regulator HPE50_RS05455 ENOG4107SET aldo keto reductase HPE50_RS05475 ENOG4105CV8 reductase HPE50_RS05480 ENOG4108KBJ Inner membrane protein YkgB HPE50_RS05485 ENOG41066GK UPF0379 protein ykgI HPE50_RS05490 ENOG4107QN2 dihydrolipoyl dehydrogenase HPE50_RS05495 ENOG4108K01 transcriptional regulator HPE50_RS05500 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPE50_RS05505 ENOG4107QR9 Iron-sulfur cluster binding protein HPE50_RS05510 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HPE50_RS05525 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HPE50_RS05535 ENOG4105ETE Transcriptional regulator (LacI family HPE50_RS05540 ENOG4108K2P TRANSCRIPTIONal HPE50_RS05575 ENOG4108SC4 )-transporter HPE50_RS05580 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HPE50_RS05600 ENOG4105SRB Uncharacterized protein yaiO HPE50_RS05610 ENOG4108PBI Polysaccharide metabolism HPE50_RS05615 ENOG4107W19 lmbE family HPE50_RS05620 ENOG4106FTQ Taurine ABC transporter, periplasmic HPE50_RS05625 ENOG4108ETV ABC transporter HPE50_RS05630 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPE50_RS05635 ENOG4105E2B Taurine dioxygenase HPE50_RS05640 ENOG4105D52 delta-aminolevulinic acid dehydratase HPE50_RS05650 ENOG4108PNB DNA-binding transcriptional regulator HPE50_RS05655 ENOG4107R6D beta-lactam binding protein AmpH HPE50_RS05660 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HPE50_RS05665 ENOG4107QS8 (LipO)protein HPE50_RS05670 ENOG4105FR5 inner membrane protein YaiY HPE50_RS05675 ENOG4105UNH Membrane HPE50_RS05680 ENOG4105CPF Cell wall formation (By similarity) HPE50_RS05695 ENOG4105G6Z alkaline phosphatase HPE50_RS05700 ENOG4105VIF phosphate starvation-inducible protein HPE50_RS05705 ENOG4105BZU Histidine kinase HPE50_RS05710 ENOG4105II7 pyrroline-5-carboxylate reductase HPE50_RS05725 ENOG4105SS3 HPE50_RS05730 ENOG4105HBA AroM protein HPE50_RS05755 ENOG4105DKQ ROK family HPE50_RS05775 ENOG4105EYH Exonuclease HPE50_RS05780 ENOG4107RH8 nuclease SbcCD subunit D HPE50_RS05785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPE50_RS05790 ENOG4105BZU Histidine kinase HPE50_RS05795 ENOG4105CWM branched-chain amino acid transport system II carrier protein HPE50_RS05800 ENOG4105C85 amino acid HPE50_RS05805 ENOG4107R28 alpha amylase, catalytic region HPE50_RS05830 ENOG4105VIE preprotein translocase, subunit YajC HPE50_RS05835 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPE50_RS05840 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPE50_RS05845 ENOG4105X54 addiction module antidote protein HPE50_RS05855 ENOG4105N1F Hnh endonuclease HPE50_RS05860 ENOG4105DRB nucleoside-specific channel-forming protein HPE50_RS05875 ENOG4105D7V transposase HPE50_RS05890 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPE50_RS05895 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HPE50_RS05905 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HPE50_RS05910 ENOG4108ZAI phosphatidylglycerophosphatase a HPE50_RS05915 ENOG4105CPC Aldo Keto reductase HPE50_RS05925 ENOG4105CTB Polyprenyl synthetase HPE50_RS05935 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HPE50_RS05940 ENOG4107S0N DJ-1 family HPE50_RS05945 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPE50_RS05955 ENOG4107RDB Major Facilitator HPE50_RS05980 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HPE50_RS05985 ENOG4105CCU oxidase (Subunit III) HPE50_RS05990 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPE50_RS05995 ENOG4105E2S oxidase) subunit II HPE50_RS06000 ENOG4105EYM Major Facilitator superfamily HPE50_RS06005 ENOG4105IEY (LipO)protein HPE50_RS06010 ENOG4105M85 Bola protein HPE50_RS06030 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HPE50_RS06035 ENOG4105K70 DNA-binding protein HPE50_RS06040 ENOG4105EIN peptidylprolyl cis-trans isomerase HPE50_RS06045 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HPE50_RS06050 ENOG4108TGP Thioesterase superfamily protein HPE50_RS06065 ENOG4108NFA extracellular solute-binding protein HPE50_RS06075 ENOG4108XM1 transcriptional regulator AsnC family HPE50_RS06080 ENOG4105BZ1 (ABC) transporter HPE50_RS06085 ENOG4105BZ1 (ABC) transporter HPE50_RS06090 ENOG4108YZA Nitrogen regulatory protein pii HPE50_RS06095 ENOG4105BZU Histidine kinase HPE50_RS06100 ENOG4105C29 acyl-CoA thioesterase HPE50_RS06105 ENOG4108MNP Glycoprotein polysaccharide metabolism HPE50_RS06110 ENOG41080UX Methyltransferase HPE50_RS06120 ENOG4105KCV RNA signal recognition particle 4.5S RNA HPE50_RS06125 ENOG41066DG (EAL) domain protein HPE50_RS06130 ENOG4105GSJ Inner membrane protein ylaC HPE50_RS06135 ENOG4108UW5 maltose o-acetyltransferase HPE50_RS06140 ENOG4105KF5 hemolysin expression-modulating protein HPE50_RS06145 ENOG4108UKR Biofilm formation regulator YbaJ HPE50_RS06150 ENOG4105BZS acriflavin resistance protein HPE50_RS06155 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPE50_RS06160 ENOG4107XI7 Tetr family transcriptional regulator HPE50_RS06165 ENOG4105EGS Mechanosensitive ion channel HPE50_RS06170 ENOG4106428 Protein of unknown function (DUF2496) HPE50_RS06175 ENOG4108URS primosomal replication protein n'' HPE50_RS06180 ENOG4105WD1 Membrane HPE50_RS06190 ENOG4107QMP dna polymerase iii subunits gamma and tau HPE50_RS06225 ENOG4107RE1 Inosine-guanosine kinase HPE50_RS06230 ENOG4105CKD glutathione-regulated potassium-efflux system protein HPE50_RS06250 ENOG4105CGH 5'-nucleotidase HPE50_RS06255 ENOG4108Z66 YbaK ebsC protein HPE50_RS06260 ENOG4105MBR gumn family HPE50_RS06265 ENOG4105EQR Transposase IS116 IS110 IS902 HPE50_RS06270 ENOG4105C59 p-type ATPase HPE50_RS06275 ENOG4105CSV Glutaminase HPE50_RS06280 ENOG4107RY6 amino acid HPE50_RS06300 ENOG4107QZV Type I secretion membrane fusion protein HPE50_RS06335 ENOG4105G5H Membrane HPE50_RS06340 ENOG4107QX8 SPFH domain, Band 7 family protein HPE50_RS06345 ENOG41083J0 (ABC) transporter HPE50_RS06350 ENOG4105C4B ABC transporter, permease HPE50_RS06355 ENOG4107QR8 Thioredoxin HPE50_RS06360 ENOG4105E1F short-chain dehydrogenase reductase HPE50_RS06365 ENOG4108UJV acyl-CoA thioesterase i HPE50_RS06370 ENOG4108I0Y (ABC) transporter HPE50_RS06375 ENOG4105CV6 ABC transporter, permease HPE50_RS06385 ENOG4107653 Transcriptional regulator HPE50_RS06395 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HPE50_RS06400 ENOG41060W2 glyoxylate carboligase HPE50_RS06405 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPE50_RS06410 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPE50_RS06415 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HPE50_RS06425 ENOG4105DTE Xanthine uracil vitamin C permease HPE50_RS06430 ENOG4105BZW Glycerate kinase HPE50_RS06445 ENOG4107REC cytoplasmic protein HPE50_RS06450 ENOG4105G5A Protein of unknown function (DUF2877) HPE50_RS06455 ENOG4105C5B carbamate kinase HPE50_RS06460 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPE50_RS06465 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPE50_RS06475 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HPE50_RS06485 ENOG4105S2T inner membrane protein YbcI HPE50_RS06490 ENOG4105WQ3 Rna-binding protein HPE50_RS06500 ENOG4108WDE Fimbrial protein HPE50_RS06505 ENOG4108AF8 Chaperone HPE50_RS06510 ENOG4105CW0 outer membrane usher protein HPE50_RS06515 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HPE50_RS06520 ENOG4108ZI2 Fimbrial protein HPE50_RS06525 ENOG4108Q9V regulatoR HPE50_RS06535 ENOG4108KU3 Integrase HPE50_RS06545 ENOG41077V0 CPS-53 (KpLE1) prophage HPE50_RS06550 ENOG4108R7K Metal Dependent Phosphohydrolase HPE50_RS06570 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HPE50_RS06575 ENOG4105KUS lysozyme HPE50_RS06580 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HPE50_RS06600 ENOG4106YSC HPE50_RS06605 ENOG4105FKG DNA packaging protein HPE50_RS06610 ENOG4105UZW Tail fiber assembly protein HPE50_RS06615 ENOG4107DE1 head-to-tail joining protein HPE50_RS06625 ENOG4105F7J membrane-bound serine protease HPE50_RS06635 ENOG4105IM0 capsid protein HPE50_RS06710 ENOG4108X9F tail fiber protein HPE50_RS06735 ENOG4108WF3 methyltransferase HPE50_RS06750 ENOG4108NC2 Outer membrane protease HPE50_RS06760 ENOG4105QUW HPE50_RS06765 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HPE50_RS06770 ENOG410802X bacteriophage n4 adsorption protein b HPE50_RS06775 ENOG4105GR3 Histidine kinase HPE50_RS06780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPE50_RS06785 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPE50_RS06790 ENOG410624V efflux system protein HPE50_RS06795 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HPE50_RS06800 ENOG4108IJF Heavy metal efflux pump, CzcA HPE50_RS06805 ENOG4105C85 amino acid HPE50_RS06810 ENOG4105CUY Mechanosensitive ion channel HPE50_RS06815 ENOG4108RCM Nitroreductase HPE50_RS06820 ENOG4105MSB protein, conserved in bacteria HPE50_RS06825 ENOG4105WQ6 Membrane HPE50_RS06850 ENOG4108TSE Transferase HPE50_RS06855 ENOG4107RNH Outer membrane receptor FepA HPE50_RS06860 ENOG4105E93 esterase HPE50_RS06865 ENOG41085A6 mbth domain-containing protein HPE50_RS06870 ENOG4105C0W non-ribosomal peptide synthetase HPE50_RS06875 ENOG4108QY5 Ferric enterobactin transport protein HPE50_RS06880 ENOG4105E0A ABC, transporter HPE50_RS06885 ENOG4105TVJ transport system, permease HPE50_RS06890 ENOG4105DQ5 transport system permease protein HPE50_RS06900 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HPE50_RS06905 ENOG4105E4F Isochorismate synthase HPE50_RS06910 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPE50_RS06915 ENOG4105WQI isochorismatase HPE50_RS06920 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HPE50_RS06925 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HPE50_RS06930 ENOG4105D22 carbon starvation protein HPE50_RS06935 ENOG4105VCD cytoplasmic protein HPE50_RS06940 ENOG4107SCQ Iron-containing alcohol dehydrogenase HPE50_RS06945 ENOG4105CHM Aminotransferase HPE50_RS06950 ENOG4105GTN ParB Domain Protein Nuclease HPE50_RS06955 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HPE50_RS06960 ENOG4105DQS Transcriptional regulator HPE50_RS06965 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HPE50_RS06970 ENOG4105D3R alkyl hydroperoxide reductase HPE50_RS06975 ENOG4108JU3 Alkyl hydroperoxide reductase HPE50_RS06980 ENOG4108U51 Universal stress protein HPE50_RS06985 ENOG4105NXH GreA GreB family elongation factor HPE50_RS06990 ENOG4105KTS ribonuclease HPE50_RS06995 ENOG4107QPK )-transporter HPE50_RS07010 ENOG4105CHY citrate lyase, alpha HPE50_RS07015 ENOG4105CI0 Citrate lyase HPE50_RS07025 ENOG4105DUA (citrate (pro-3S)-lyase ligase HPE50_RS07030 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPE50_RS07035 ENOG4106YYS transcriptional regulatory protein HPE50_RS07040 ENOG4105CEE C4-dicarboxylate transporter HPE50_RS07065 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HPE50_RS07075 ENOG41064T2 transcriptional regulator, lysR family HPE50_RS07095 ENOG4105DZ1 carboxypeptidase HPE50_RS07100 ENOG4105K6T rare lipoprotein A HPE50_RS07105 ENOG4105CNI cell division protein FtsW HPE50_RS07110 ENOG4105CJN penicillin-binding protein HPE50_RS07120 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HPE50_RS07125 ENOG4108TGR phosphatase HPE50_RS07135 ENOG4105DJF DNA polymerase III, delta' subunit HPE50_RS07140 ENOG4108U2H Rare lipoprotein B HPE50_RS07150 ENOG4107PAI alpha helical protein HPE50_RS07160 ENOG4105CDA abc transporter atp-binding protein HPE50_RS07165 ENOG4105DRP amino acid AbC transporter HPE50_RS07170 ENOG4105EAD ABC transporter HPE50_RS07175 ENOG4107RP9 extracellular solute-binding protein, family 3 HPE50_RS07180 ENOG4107U91 Rhomboid family HPE50_RS07185 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HPE50_RS07190 ENOG4108JU5 Magnesium and cobalt efflux protein HPE50_RS07200 ENOG4105C9A Phoh family HPE50_RS07210 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPE50_RS07255 ENOG4105CAQ asparagine synthetase HPE50_RS07260 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPE50_RS07265 ENOG4105E2R ROK family HPE50_RS07270 ENOG4105CE4 GlcNAc 6-P deacetylase HPE50_RS07280 ENOG4105CI1 PTS System HPE50_RS07295 ENOG4105GX6 (LipO)protein HPE50_RS07300 ENOG41090R7 Ferric uptake HPE50_RS07310 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HPE50_RS07315 ENOG4105NNH LexA regulated protein HPE50_RS07320 ENOG4105EV9 Alpha Beta Hydrolase HPE50_RS07325 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HPE50_RS07330 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HPE50_RS07335 ENOG4105D5Q Arginine ornithine antiporter HPE50_RS07340 ENOG4105CXN decarboxylase HPE50_RS07350 ENOG4105EEX Two component transcriptional regulator (Winged helix family HPE50_RS07355 ENOG4105C08 Histidine kinase HPE50_RS07380 ENOG4105XIQ Protein of unknown function (DUF2517) HPE50_RS07385 ENOG4107SEY Conserved Protein HPE50_RS07390 ENOG4105CVP deoxyribo-dipyrimidine photolyase HPE50_RS07395 ENOG4105DUX Transporter HPE50_RS07400 ENOG4107QNR UPF0135 protein HPE50_RS07405 ENOG4105P4J Allophanate hydrolase, subunit 1 HPE50_RS07410 ENOG4107R7A Allophanate hydrolase subunit 2 HPE50_RS07425 ENOG4108KK1 membrane protein AbrB duplication HPE50_RS07435 ENOG4105BZN citrate synthase HPE50_RS07445 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HPE50_RS07450 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HPE50_RS07455 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HPE50_RS07460 ENOG4105E33 succinate dehydrogenase HPE50_RS07465 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HPE50_RS07470 ENOG4105C7S Dehydrogenase HPE50_RS07480 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPE50_RS07500 ENOG4105ETT transcriptional Regulator, LysR family HPE50_RS07505 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HPE50_RS07510 ENOG4107GFK fumarate HPE50_RS07535 ENOG4105DJI Methylaspartate mutase, E subunit HPE50_RS07545 ENOG4107WFU Glutamate mutase subunit sigma HPE50_RS07560 ENOG4105C4M (Ubiquinol oxidase) subunit I HPE50_RS07565 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPE50_RS07575 ENOG4105KJB cyd operon protein YbgE HPE50_RS07580 ENOG4107YD3 Thioesterase HPE50_RS07585 ENOG4105E02 MotA TolQ exbB proton channel HPE50_RS07595 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HPE50_RS07605 ENOG4105KCK Peptidoglycan-associated lipoprotein HPE50_RS07610 ENOG4105UFD tol-pal system protein YbgF HPE50_RS07660 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HPE50_RS07665 ENOG4105PGM cation diffusion facilitator family transporter HPE50_RS07670 ENOG4105JND homeobox protein HPE50_RS07675 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPE50_RS07685 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HPE50_RS07695 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HPE50_RS07700 ENOG4105CMR udp-glucose 4-epimerase HPE50_RS07705 ENOG4105DKW ABC transporter HPE50_RS07710 ENOG4105F4R Transcriptional regulator mode HPE50_RS07720 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPE50_RS07725 ENOG4105E0C molybdate abc transporter HPE50_RS07735 ENOG4108K4B hydrolase HPE50_RS07750 ENOG4105C7F AcnD-accessory protein PrpF HPE50_RS07755 ENOG4107QPK )-transporter HPE50_RS07760 ENOG4107QM5 aconitate hydratase HPE50_RS07765 ENOG4105NBR Pectinesterase HPE50_RS07770 ENOG4108V1U phospholipid-binding protein HPE50_RS07775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPE50_RS07790 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPE50_RS07795 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPE50_RS07805 ENOG4105CHW UPF0052 protein HPE50_RS07815 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPE50_RS07825 ENOG4105M00 molybdopterin converting factor, subunit 1 HPE50_RS07830 ENOG4108ZAF Molybdopterin HPE50_RS07835 ENOG4105HFZ Membrane HPE50_RS07840 ENOG410733J conserved inner membrane protein HPE50_RS07845 ENOG4107UXM Membrane HPE50_RS07850 ENOG4105DZQ phospholipase D Transphosphatidylase HPE50_RS07855 ENOG4105X23 Endonuclease Exonuclease phosphatase HPE50_RS07860 ENOG4105I9U inner membrane protein ybhQ HPE50_RS07865 ENOG4107QWP ABC-2 type transporter HPE50_RS07870 ENOG4107QWP ABC-2 type transporter HPE50_RS07875 ENOG4105CJ1 ABC, transporter HPE50_RS07885 ENOG4107MVR Transcriptional regulator HPE50_RS07890 ENOG4105C1J atp-dependent rna helicase HPE50_RS07900 ENOG4105DVT helicase HPE50_RS07905 ENOG4108MTB glycosyl transferase family HPE50_RS07910 ENOG4105DG4 malate L-lactate dehydrogenase HPE50_RS07915 ENOG4105VR4 UPF0379 protein ybiJ HPE50_RS07920 ENOG4105KSC Transcriptional regulator, TraR DksA family HPE50_RS07930 ENOG4108IU3 tonb-dependent siderophore receptor HPE50_RS07935 ENOG4105ZY9 UPF0379 protein ybiM HPE50_RS07945 ENOG4105D8X mechanosensitive ion channel HPE50_RS07950 ENOG4105CDA abc transporter atp-binding protein HPE50_RS07955 ENOG4105E5Q amino acid AbC transporter HPE50_RS07960 ENOG4107R0W ABC transporter HPE50_RS07970 ENOG4107AQZ Membrane HPE50_RS07980 ENOG4108T1M outer membrane protein x HPE50_RS07985 ENOG4108I6E Sulfatase HPE50_RS07995 ENOG4105KST dependent repressor HPE50_RS08000 ENOG4105F4P )-transporter HPE50_RS08005 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPE50_RS08010 ENOG4105C5H ABC transporter HPE50_RS08020 ENOG4105DPW Major facilitator superfamily MFS_1 HPE50_RS08025 ENOG4105ETE Transcriptional regulator (LacI family HPE50_RS08030 ENOG41072TH Protein of unknown function (DUF1479) HPE50_RS08035 ENOG4108HCJ Hydrolase HPE50_RS08045 ENOG4105F1A Pyruvate formate-lyase HPE50_RS08050 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPE50_RS08055 ENOG4105D06 uba thif-type nad fad binding protein HPE50_RS08060 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPE50_RS08065 ENOG4105D44 asparaginase HPE50_RS08070 ENOG4108JQ6 ABC transporter HPE50_RS08075 ENOG4105DEF Extracellular solute-binding protein, family 5 HPE50_RS08090 ENOG4105BZU Histidine kinase HPE50_RS08095 ENOG41064RH membrane protein YliF HPE50_RS08115 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HPE50_RS08120 ENOG4105D8V Glucose sorbosone dehydrogenase HPE50_RS08125 ENOG4108TGY Glutathione S-transferase HPE50_RS08130 ENOG4105DZ1 carboxypeptidase HPE50_RS08135 ENOG4107FB0 transcriptional regulator DeoR family HPE50_RS08140 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPE50_RS08145 ENOG4107QF7 multi-drug HPE50_RS08155 ENOG4108HCJ Hydrolase HPE50_RS08160 ENOG4106UW1 Major Facilitator superfamily HPE50_RS08165 ENOG4108RFG Tetr family transcriptional regulator HPE50_RS08175 ENOG4105GWF inner membrane protein YbjM HPE50_RS08180 ENOG41090BQ Glutaredoxin HPE50_RS08185 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HPE50_RS08190 ENOG4108DBC nitroreductase HPE50_RS08200 ENOG4108RMJ sensory transduction regulator HPE50_RS08205 ENOG4107RUE extracellular solute-binding protein family 1 HPE50_RS08210 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPE50_RS08215 ENOG4105F38 ABC transporter, permease HPE50_RS08220 ENOG4105D38 putrescine abc transporter HPE50_RS08225 ENOG4105RBQ inner membrane protein ybjO HPE50_RS08235 ENOG4106TNF Periplasmic binding protein HPE50_RS08240 ENOG4105DMR ABC, transporter HPE50_RS08245 ENOG4105GBT ABC transporter HPE50_RS08250 ENOG4106PMH Extracellular solute-binding protein family 3 HPE50_RS08255 ENOG4105E5Z arginine transporter ATP-binding subunit HPE50_RS08260 ENOG41064MM (LipO)protein HPE50_RS08275 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HPE50_RS08280 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HPE50_RS08285 ENOG4105CGD Nad-dependent epimerase dehydratase HPE50_RS08290 ENOG4105C5W Aldolase HPE50_RS08295 ENOG4105C7K acetolactate synthase HPE50_RS08300 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPE50_RS08310 ENOG4105DWU Membrane HPE50_RS08315 ENOG4105EQR Transposase IS116 IS110 IS902 HPE50_RS08325 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPE50_RS08330 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HPE50_RS08335 ENOG4105KHU inner membrane protein YohD HPE50_RS08340 ENOG41069YE inner membrane protein yohC HPE50_RS08345 ENOG41061WM D-Alanyl-D-Alanine HPE50_RS08350 ENOG4105CXG d-lactate dehydrogenase HPE50_RS08355 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HPE50_RS08360 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HPE50_RS08365 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HPE50_RS08370 ENOG4108IJ8 ABC transporter HPE50_RS08375 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HPE50_RS08385 ENOG4108XDN Transcriptional regulator HPE50_RS08390 ENOG4107R08 Integrase HPE50_RS08435 ENOG41077V0 CPS-53 (KpLE1) prophage HPE50_RS08440 ENOG4108R7K Metal Dependent Phosphohydrolase HPE50_RS08460 ENOG4108S1U HPE50_RS08465 ENOG4106050 phage regulatory protein, rha family HPE50_RS08470 ENOG4106050 phage regulatory protein, rha family HPE50_RS08500 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HPE50_RS08510 ENOG4108MXB Protein of unknown function (DUF968) HPE50_RS08515 ENOG4105HRS Antitermination protein HPE50_RS08565 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HPE50_RS08580 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HPE50_RS08595 ENOG4106YSC HPE50_RS08630 ENOG4105IM0 capsid protein HPE50_RS08705 ENOG4108X9F tail fiber protein HPE50_RS08720 ENOG4106FE3 DNA repair HPE50_RS08725 ENOG4108HRK Histidine kinase HPE50_RS08730 ENOG4108NEV two component transcriptional regulator, LytTR family HPE50_RS08735 ENOG4108W15 Protein of unknown function (DUF1456) HPE50_RS08740 ENOG4108YCW (LipO)protein HPE50_RS08745 ENOG410903U zinc ion binding HPE50_RS08755 ENOG4105RD5 HPE50_RS08760 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HPE50_RS08780 ENOG4105VNT transposase (IS4 family) protein HPE50_RS08795 ENOG4105D1F ATP-binding protein HPE50_RS08800 ENOG41067AK Protein of unknown function (DUF2574) HPE50_RS08820 ENOG4105DWF phosphomethylpyrimidine kinase HPE50_RS08825 ENOG4108UQ1 hydrolase, family 25 HPE50_RS08830 ENOG4105FDP GntR family transcriptional regulator HPE50_RS08835 ENOG4108TFM Kinase, PfkB family HPE50_RS08840 ENOG4108KD5 ADP-ribosylation crystallin J1 HPE50_RS08845 ENOG4105EAA nucleoside HPE50_RS08855 ENOG4105EIE fructose-bisphosphate aldolase HPE50_RS08885 ENOG41090UW PTS System HPE50_RS08890 ENOG4105DT3 PTS system, galactitol-specific IIc component HPE50_RS08895 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HPE50_RS08910 ENOG41076Z6 Uncharacterized protein yegR HPE50_RS08915 ENOG4105CFP Peptidase U32 HPE50_RS08925 ENOG4105X54 addiction module antidote protein HPE50_RS08930 ENOG4105KWI UPF0339 protein HPE50_RS08935 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPE50_RS08940 ENOG4105EB3 Histidine kinase HPE50_RS08975 ENOG4108M24 von Willebrand factor, type A HPE50_RS08980 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HPE50_RS08985 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HPE50_RS08990 ENOG4105R8A Heat shock protein HPE50_RS08995 ENOG4105D03 DNA-3-methyladenine glycosylase II HPE50_RS09005 ENOG4105DBI uridine monophosphokinase HPE50_RS09015 ENOG4108GAE asmA family HPE50_RS09030 ENOG4105EE5 Membrane protein terC HPE50_RS09040 ENOG4105DAY polysaccharide export protein HPE50_RS09045 ENOG4105KJF protein tyrosine phosphatase HPE50_RS09050 ENOG4105D75 Capsular exopolysaccharide family HPE50_RS09055 ENOG41090RK glycosyl transferase HPE50_RS09060 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HPE50_RS09065 ENOG4107RXY Glycosyl transferase HPE50_RS09070 ENOG4108NYJ Colanic acid HPE50_RS09075 ENOG4105ECJ Glycosyl Transferase HPE50_RS09080 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HPE50_RS09085 ENOG4105C0K Gdp-mannose 4,6-dehydratase HPE50_RS09090 ENOG4105C30 Nad-dependent epimerase dehydratase HPE50_RS09095 ENOG4105FGF GDP-mannose mannosyl hydrolase HPE50_RS09100 ENOG4106CD9 glycosyl transferase group 1 HPE50_RS09105 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HPE50_RS09110 ENOG4107QKV phosphomannomutase HPE50_RS09115 ENOG4105D3Q Sugar transferase HPE50_RS09120 ENOG4105PSV Polysaccharide Biosynthesis Protein HPE50_RS09125 ENOG4105C74 pyruvyl transferase HPE50_RS09130 ENOG4107T8Q Glycosyl transferase (Group 1 HPE50_RS09135 ENOG4105G1A colanic acid biosynthesis protein HPE50_RS09140 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPE50_RS09145 ENOG4105C1B dTDP-glucose 4-6-dehydratase HPE50_RS09150 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HPE50_RS09155 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HPE50_RS09160 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HPE50_RS09170 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPE50_RS09185 ENOG4105K64 Glycosyl transferase, family 2 HPE50_RS09195 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HPE50_RS09200 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPE50_RS09205 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HPE50_RS09210 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HPE50_RS09225 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HPE50_RS09230 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HPE50_RS09235 ENOG4105CIH Imidazole acetol-phosphate transaminase HPE50_RS09240 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HPE50_RS09255 ENOG4105VTW prevent-host-death family HPE50_RS09260 ENOG4105KRQ Addiction module toxin, Txe YoeB family HPE50_RS09265 ENOG4107SRH Nad-dependent epimerase dehydratase HPE50_RS09270 ENOG4105EQ1 Transcriptional regulator HPE50_RS09280 ENOG4105CUB amino acid HPE50_RS09285 ENOG4105CUC YeeE YedE family protein HPE50_RS09295 ENOG4105CJB Exodeoxyribonuclease I HPE50_RS09300 ENOG4105DZ1 carboxypeptidase HPE50_RS09320 ENOG4105DR8 Membrane HPE50_RS09355 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HPE50_RS09365 ENOG4108YGG dna repair protein HPE50_RS09370 ENOG4105MFG Antirestriction protein HPE50_RS09380 ENOG4108YZT Adenosylcobinamide kinase HPE50_RS09395 ENOG4108PXI ErfK YbiS YcfS YnhG HPE50_RS09405 ENOG4106P55 Transcriptional regulator HPE50_RS09410 ENOG4107R11 Transcriptional regulator HPE50_RS09420 ENOG4105UQX Mate efflux family protein HPE50_RS09430 ENOG4105CDY transcriptional regulatory protein HPE50_RS09435 ENOG4105FYV Amp nucleosidase HPE50_RS09440 ENOG4105CSH Transporter HPE50_RS09450 ENOG4105TNG K13735 adhesin invasin HPE50_RS09455 ENOG4105TNG K13735 adhesin invasin HPE50_RS09460 ENOG4105TNG K13735 adhesin invasin HPE50_RS09465 ENOG4107ZSV Receptor HPE50_RS09470 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPE50_RS09505 ENOG4105BZ1 (ABC) transporter HPE50_RS09510 ENOG4105EYM Major Facilitator superfamily HPE50_RS09550 ENOG41076J9 exonuclease VIII HPE50_RS09555 ENOG4106G8A Qin prophage HPE50_RS09580 ENOG41087BU transcriptional repressor DicA HPE50_RS09665 ENOG4108MXB Protein of unknown function (DUF968) HPE50_RS09670 ENOG4105KSK (crossover) junction endodeoxyribonuclease HPE50_RS09675 ENOG4105HGD Antitermination protein HPE50_RS09715 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HPE50_RS09740 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HPE50_RS09785 ENOG4105IM0 capsid protein HPE50_RS09860 ENOG4108X9F tail fiber protein HPE50_RS09875 ENOG4108MEK Metal-binding protein YodA HPE50_RS09880 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HPE50_RS09890 ENOG4105VT2 5-hydroxyisourate hydrolase HPE50_RS09895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPE50_RS09900 ENOG4107ZY3 Histidine kinase HPE50_RS09910 ENOG4105ZIT Porin Gram-negative type HPE50_RS09915 ENOG4105Y0K Inner membrane protein YedR HPE50_RS09920 ENOG4105EST Metal Dependent Phosphohydrolase HPE50_RS09925 ENOG4105DVF Cytosine-specific methyltransferase HPE50_RS09930 ENOG41090BB DNA mismatch endonuclease (vsr) HPE50_RS09935 ENOG4105FDR Membrane HPE50_RS09940 ENOG4105CKW Inner membrane protein yedI HPE50_RS09945 ENOG4105VNZ cytoplasmic protein HPE50_RS09970 ENOG4105ZIA Phage protein gp16 HPE50_RS10005 ENOG4105IKI host-nuclease inhibitor protein HPE50_RS10090 ENOG4105CF2 Mu-like prophage FluMu protein GP28 HPE50_RS10100 ENOG4108QUU Morphogenesis Protein HPE50_RS10220 ENOG4108C33 Resolvase HPE50_RS10235 ENOG4105YX3 cellular response to acidity HPE50_RS10245 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HPE50_RS10260 ENOG4108RAV Conserved protein HPE50_RS10270 ENOG41066VF YeeE YedE family protein HPE50_RS10275 ENOG4108W9D (LipO)protein HPE50_RS10280 ENOG4105E5K Alpha-amylase HPE50_RS10290 ENOG4105MQ3 flagellar protein FliS HPE50_RS10295 ENOG4105DTS flagellar hook-associated HPE50_RS10300 ENOG4105I03 Flagellin HPE50_RS10305 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPE50_RS10310 ENOG4108M9K flagella biosynthesis protein FliZ HPE50_RS10315 ENOG4105EAB amino acid AbC transporter HPE50_RS10325 ENOG4105E5Q amino acid AbC transporter HPE50_RS10330 ENOG4105CDA abc transporter atp-binding protein HPE50_RS10335 ENOG4105VJY transcriptional regulator HPE50_RS10340 ENOG4105XVG cytoplasmic protein HPE50_RS10350 ENOG4105WH1 Two component transcriptional regulator luxr family HPE50_RS10380 ENOG4106RHG Yeca family HPE50_RS10385 ENOG4105E0U tyrosine-specific transport protein HPE50_RS10390 ENOG4105VVZ metal-binding protein HPE50_RS10395 ENOG41090A1 ferritin HPE50_RS10400 ENOG4105P23 (LipO)protein HPE50_RS10410 ENOG4105N4N Protein of unknown function (DUF2766) HPE50_RS10415 ENOG4108UEC Ferritin-like protein HPE50_RS10420 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HPE50_RS10430 ENOG4105CNN ABC, transporter HPE50_RS10435 ENOG4108K4C ec 3.1.3.12 HPE50_RS10440 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HPE50_RS10445 ENOG4108VA4 Universal stress protein HPE50_RS10455 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HPE50_RS10465 ENOG4105VNT transposase (IS4 family) protein HPE50_RS10475 ENOG4105ER2 Ompa motb domain protein HPE50_RS10480 ENOG4105CBS Chea signal transduction histidine kinase HPE50_RS10485 ENOG4108V3W Chemotaxis protein, CheW HPE50_RS10490 ENOG4105C8Q Methyl-accepting chemotaxis HPE50_RS10500 ENOG4105BZU Histidine kinase HPE50_RS10510 ENOG4108VYJ response regulator receiver protein HPE50_RS10515 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HPE50_RS10525 ENOG4105D7B Flagellar biosynthesis protein flha HPE50_RS10530 ENOG4105W13 flagellar protein HPE50_RS10535 ENOG4105C75 arginyL-tRNA synthetase HPE50_RS10540 ENOG4106ZCM YecM protein HPE50_RS10550 ENOG4105CUW cytochrome C-TYPE protein HPE50_RS10555 ENOG4108J2R molybdopterin oxidoreductase HPE50_RS10560 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HPE50_RS10570 ENOG4105WJG Glutathione HPE50_RS10575 ENOG41081XQ Conserved Protein HPE50_RS10580 ENOG4105D3W isochorismatase HPE50_RS10590 ENOG4108TIT dATP pyrophosphohydrolase HPE50_RS10595 ENOG4105CDY transcriptional regulatory protein HPE50_RS10605 ENOG4107S01 Repressor protein MetJ HPE50_RS10625 ENOG4105FAV ABC, transporter HPE50_RS10635 ENOG4105NXV High-affinity zinc uptake system protein HPE50_RS10640 ENOG4105DR5 peptidase HPE50_RS10645 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HPE50_RS10650 ENOG4105CA9 Pyruvate kinase HPE50_RS10655 ENOG4106KNT transcriptional regulator HPE50_RS10660 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPE50_RS10665 ENOG4105C01 Dihydroxy-acid dehydratase HPE50_RS10670 ENOG4108UHU Aldolase HPE50_RS10680 ENOG4105X2V dna damage-inducible protein HPE50_RS10690 ENOG4108Q2J Inner membrane protein YebE HPE50_RS10695 ENOG4105CUG Oligopeptidase b HPE50_RS10700 ENOG4105UMD exodeoxyribonuclease X HPE50_RS10705 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPE50_RS10710 ENOG4105MPK DNA polymerase III subunit theta HPE50_RS10715 ENOG4105FXM Copper resistance protein HPE50_RS10720 ENOG4108PNC copper resistance HPE50_RS10725 ENOG4105NKT exported protein HPE50_RS10730 ENOG4108R1E Serine threonine protein phosphatase 1 HPE50_RS10735 ENOG4105UVW uncharacterized protein yebW HPE50_RS10740 ENOG4105WT8 Protein of unknown function (DUF1480) HPE50_RS10750 ENOG4105DY2 Paraquat-inducible protein b HPE50_RS10755 ENOG4105H2K paraquat-inducible protein a HPE50_RS10760 ENOG4108ZGC gaf domain protein HPE50_RS10770 ENOG4105CN1 protease HPE50_RS10780 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPE50_RS10785 ENOG4105J4Q Transcriptional regulator HPE50_RS10790 ENOG4105TIK HPE50_RS10800 ENOG4105Q3Y exported protein HPE50_RS10815 ENOG4105DHI Methyltransferase HPE50_RS10830 ENOG4105F3R pts system mannose fructose sorbose family iid HPE50_RS10835 ENOG4105ETZ PTS System HPE50_RS10840 ENOG4105DAS pts system HPE50_RS10845 ENOG4105EE5 Membrane protein terC HPE50_RS10850 ENOG4107XTP (EAL) domain protein HPE50_RS10855 ENOG4105EJQ L-serine dehydratase HPE50_RS10860 ENOG4105P8F nudix hydrolase HPE50_RS10865 ENOG4105CRQ synthase (Component I) HPE50_RS10875 ENOG4105V2F Uncharacterized protein yoac HPE50_RS10880 ENOG4105M4H endoribonuclease L-psp HPE50_RS10885 ENOG4105DVT helicase HPE50_RS10890 ENOG41072GX Peptidase M22 Glycoprotease HPE50_RS10895 ENOG4105Y4Z Outer Membrane Lipoprotein HPE50_RS10900 ENOG4105CEY Amp-dependent synthetase and ligase HPE50_RS10905 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HPE50_RS10910 ENOG4105E3J oxidoreductase HPE50_RS10915 ENOG4105DVW rieske (2Fe-2S) HPE50_RS10920 ENOG4105C94 Transporter HPE50_RS10925 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPE50_RS10930 ENOG4105EJC lysr family transcriptional regulator HPE50_RS10940 ENOG4108YS1 cytoplasmic protein HPE50_RS10945 ENOG4105YP6 Domain of unknown function (DUF1869) HPE50_RS10950 ENOG4105Y3U Transglycosylase-associated protein HPE50_RS10960 ENOG4106G4W HPE50_RS10965 ENOG410620I Diguanylate cyclase HPE50_RS10970 ENOG4105UCG Domain of unknown function (DUF333) HPE50_RS10975 ENOG4105K78 MarR family Transcriptional regulator HPE50_RS10980 ENOG4105DJ2 Major Facilitator Superfamily HPE50_RS10985 ENOG4105R1U AraC Family Transcriptional Regulator HPE50_RS11000 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HPE50_RS11005 ENOG4108KHP Diguanylate cyclase HPE50_RS11010 ENOG4106KTS Inner membrane protein yeaI HPE50_RS11020 ENOG4105CYN Serine protein kinase HPE50_RS11025 ENOG4105GNX MltA-interacting MipA family protein HPE50_RS11030 ENOG4105CV8 reductase HPE50_RS11035 ENOG4105DSB aldose 1-epimerase HPE50_RS11040 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPE50_RS11050 ENOG4105VUT cytoplasmic protein HPE50_RS11055 ENOG4105CPQ Dehydrogenase HPE50_RS11060 ENOG4107TE1 transport protein HPE50_RS11065 ENOG4105CPQ Dehydrogenase HPE50_RS11070 ENOG4105D2N Aldolase HPE50_RS11075 ENOG4107UH8 sugar kinase HPE50_RS11080 ENOG4105CPC Aldo Keto reductase HPE50_RS11085 ENOG4105E98 transcriptional regulator DeoR family HPE50_RS11090 ENOG4108KUU Inner membrane metabolite transport protein ydjE HPE50_RS11095 ENOG4108RWI nicotinamidase HPE50_RS11100 ENOG4105HDK L-asparaginase HPE50_RS11105 ENOG4105D07 Signal peptide peptidase, SppA HPE50_RS11110 ENOG41069NU Nitroreductase HPE50_RS11115 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HPE50_RS11120 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPE50_RS11125 ENOG4105D82 Glutamate dehydrogenase HPE50_RS11130 ENOG4105MTM Protein of unknown function (DUF1496) HPE50_RS11135 ENOG4105M6F mutator MutT protein HPE50_RS11140 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HPE50_RS11145 ENOG4107RM6 sulfurtransferase HPE50_RS11150 ENOG4108VGW abc transporter atp-binding protein HPE50_RS11155 ENOG4105CXZ ABC transporter, permease HPE50_RS11160 ENOG4105VNH ABC transporter solute-binding protein HPE50_RS11165 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPE50_RS11170 ENOG4108N5C SNARE associated Golgi protein-related protein HPE50_RS11175 ENOG4108KCW iron-sulfur cluster binding HPE50_RS11180 ENOG4108RSN SNARE associated Golgi HPE50_RS11185 ENOG4105CGK Exodeoxyribonuclease III HPE50_RS11215 ENOG4108SPG Periplasmic Protein HPE50_RS11225 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HPE50_RS11235 ENOG4105KKI DNA-binding transcriptional activator OsmE HPE50_RS11240 ENOG4105VZJ PTS System HPE50_RS11245 ENOG4105CK1 PTS System HPE50_RS11250 ENOG4105VCP PTS System HPE50_RS11255 ENOG4105EZV Transcriptional regulator HPE50_RS11260 ENOG4105F8D glycoside hydrolase family 4 HPE50_RS11270 ENOG4105CH6 catalase HPE50_RS11285 ENOG4108ETY sodium dicarboxylate symporter HPE50_RS11290 ENOG4107K5X Membrane-bound metal-dependent hydrolase HPE50_RS11295 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HPE50_RS11300 ENOG4107PN8 YfeABCD locus regulator HPE50_RS11310 ENOG4105P10 Uncharacterized protein ydiZ HPE50_RS11315 ENOG4105DE4 1-phosphofructokinase HPE50_RS11320 ENOG4108NE3 Salt-induced outer membrane protein HPE50_RS11340 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HPE50_RS11345 ENOG41082NX 50s ribosomal protein l35 HPE50_RS11515 ENOG4105ED4 portal protein HPE50_RS11600 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPE50_RS11615 ENOG4108V06 Glutathione peroxidase HPE50_RS11625 ENOG4108QBX (LipO)protein HPE50_RS11630 ENOG4108TC0 Diguanylate phosphodiesterase HPE50_RS11645 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPE50_RS11655 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPE50_RS11660 ENOG4107QPK )-transporter HPE50_RS11665 ENOG4105C5I Dehydrogenase HPE50_RS11675 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPE50_RS11695 ENOG41090P5 ferredoxin-like protein HPE50_RS11700 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPE50_RS11705 ENOG4105C10 Electron transfer flavoprotein HPE50_RS11710 ENOG4105CV7 Electron transfer flavoprotein HPE50_RS11715 ENOG4105W4W Transcriptional regulator HPE50_RS11730 ENOG4105C1G acyl-Coa dehydrogenase HPE50_RS11735 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HPE50_RS11750 ENOG4105EMV Major Facilitator HPE50_RS11755 ENOG4105EMV Major Facilitator HPE50_RS11760 ENOG4105SUA Ydil protein HPE50_RS11770 ENOG4105IPI Membrane HPE50_RS11775 ENOG4105CQB FAD linked oxidase domain protein HPE50_RS11780 ENOG4105KA0 thioesterase Superfamily protein HPE50_RS11785 ENOG410671Z uncharacterized protein ydiH HPE50_RS11790 ENOG4108Z4V iron-sulfur cluster assembly HPE50_RS11795 ENOG4105DIW FeS assembly protein SUFB HPE50_RS11800 ENOG4105C3K feS assembly ATPase SufC HPE50_RS11805 ENOG4105JRK feS assembly protein SufD HPE50_RS11820 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPE50_RS11825 ENOG4105KMX major outer membrane lipoprotein HPE50_RS11830 ENOG4105CA9 Pyruvate kinase HPE50_RS11835 ENOG4105RFR Protein of unknown function (DUF2767) HPE50_RS11840 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HPE50_RS11845 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HPE50_RS11850 ENOG4105JVW HPE50_RS11855 ENOG4108393 oxidoreductase Fe-S subunit HPE50_RS11860 ENOG4108NWD Cytochrome HPE50_RS11865 ENOG4108Y7C Conserved Protein HPE50_RS11870 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HPE50_RS11875 ENOG4105N0V mono-oxygenase ydhR HPE50_RS11900 ENOG4108R6K riboflavin synthase, subunit alpha HPE50_RS11905 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPE50_RS11910 ENOG4105CZQ inner membrane transport protein YdhC HPE50_RS11915 ENOG4105F52 Transcriptional regulator HPE50_RS11930 ENOG4105F27 Major Facilitator HPE50_RS11935 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPE50_RS11940 ENOG4105K4H Nlp p60 protein HPE50_RS11945 ENOG4105M2J Glutaredoxin HPE50_RS11950 ENOG4107QRT dEAD DEAH box helicase HPE50_RS11960 ENOG4108UYE Lactoylglutathione lyase HPE50_RS11965 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPE50_RS11970 ENOG4108WUH Transcriptional regulator, TetR family HPE50_RS11975 ENOG4105XZD Fe-S protein HPE50_RS11980 ENOG4107RGM aldo keto reductase HPE50_RS11985 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPE50_RS11990 ENOG4105DSW Fusaric acid resistance protein HPE50_RS11995 ENOG4105Y49 secretion protein, HlyD family HPE50_RS12010 ENOG4108XTF Outer Membrane Lipoprotein HPE50_RS12020 ENOG410642K Lysozyme inhibitor HPE50_RS12035 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HPE50_RS12040 ENOG4108K3A Glutathione S-transferase HPE50_RS12045 ENOG4105DUX Transporter HPE50_RS12050 ENOG4105CSM endonuclease III HPE50_RS12060 ENOG4108UQQ Electron transport complex HPE50_RS12085 ENOG4105M9B inner membrane protein ydgK HPE50_RS12090 ENOG4105QZ5 OriC-binding nucleoid-associated protein HPE50_RS12095 ENOG4106C6R beta-lactam resistance protein HPE50_RS12100 ENOG4105D9R oxidoreductase HPE50_RS12110 ENOG4105C87 Aminotransferase class I and II HPE50_RS12115 ENOG4105CI1 PTS System HPE50_RS12120 ENOG4107P2S Transcriptional regulator HPE50_RS12125 ENOG4107ZQV short-chain dehydrogenase reductase HPE50_RS12130 ENOG4105XEA Tetr family transcriptional regulator HPE50_RS12140 ENOG4105CT4 transporter HPE50_RS12150 ENOG4108QNI outer membrane porin protein HPE50_RS12155 ENOG4106J39 exported protein HPE50_RS12160 ENOG4105EIP mannose-6-phosphate isomerase HPE50_RS12165 ENOG4107GFK fumarate HPE50_RS12170 ENOG4105VNT transposase (IS4 family) protein HPE50_RS12180 ENOG4106318 fimbrial-like protein YdeR HPE50_RS12185 ENOG4108WDE Fimbrial protein HPE50_RS12215 ENOG4105VNT transposase (IS4 family) protein HPE50_RS12260 ENOG41061GT Aldolase HPE50_RS12265 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HPE50_RS12275 ENOG4105FFC UPF0187 protein HPE50_RS12285 ENOG4105BZU Histidine kinase HPE50_RS12290 ENOG4105M0C cytoplasmic protein HPE50_RS12295 ENOG4105CSV Glutaminase HPE50_RS12300 ENOG4105C26 Dehydrogenase HPE50_RS12305 ENOG4105EGI Transcriptional regulator HPE50_RS12325 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HPE50_RS12330 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HPE50_RS12335 ENOG4106DNR multiple antibiotic resistance protein HPE50_RS12340 ENOG4105CS2 ec 3.2.1.21 HPE50_RS12350 ENOG4105VCP PTS System HPE50_RS12355 ENOG4105CK1 PTS System HPE50_RS12360 ENOG4105F2I Transposase HPE50_RS12370 ENOG4105FDP GntR family transcriptional regulator HPE50_RS12375 ENOG4108594 Permease of the drug metabolite transporter HPE50_RS12380 ENOG4105E5W Transporter HPE50_RS12390 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HPE50_RS12395 ENOG4108YDI single-species biofilm formation on inanimate substrate HPE50_RS12400 ENOG4105DGW oligopeptidase A HPE50_RS12405 ENOG4105EMU Dehydrogenase HPE50_RS12410 ENOG4107XBN GntR Family Transcriptional Regulator HPE50_RS12415 ENOG41061EV selenium-binding protein YdfZ HPE50_RS12420 ENOG4105DEI Mannitol dehydrogenase HPE50_RS12435 ENOG4105W3V DNA-binding, transcriptional regulator HPE50_RS12440 ENOG4105MN3 Resolvase HPE50_RS12490 ENOG4105F9F transposase HPE50_RS12535 ENOG4105IM0 capsid protein HPE50_RS12545 ENOG4105F7J membrane-bound serine protease HPE50_RS12555 ENOG4107DE1 head-to-tail joining protein HPE50_RS12560 ENOG4105UZW Tail fiber assembly protein HPE50_RS12565 ENOG4105FKG DNA packaging protein HPE50_RS12570 ENOG4106YSC HPE50_RS12575 ENOG41064WM Uncharacterized protein YcgX HPE50_RS12580 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HPE50_RS12585 ENOG4106IAW HPE50_RS12600 ENOG4105VEQ Cold shock protein HPE50_RS12620 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HPE50_RS12625 ENOG4105VEQ Cold shock protein HPE50_RS12640 ENOG4105HGD Antitermination protein HPE50_RS12645 ENOG4108MXB Protein of unknown function (DUF968) HPE50_RS12665 ENOG4105K4U addiction module toxin, RelE StbE family HPE50_RS12720 ENOG41087BU transcriptional repressor DicA HPE50_RS12745 ENOG4106G8A Qin prophage HPE50_RS12760 ENOG41076J9 exonuclease VIII HPE50_RS12770 ENOG4107R08 Integrase HPE50_RS12780 ENOG4105CPQ Dehydrogenase HPE50_RS12785 ENOG4105CXK mandelate racemase muconate lactonizing HPE50_RS12800 ENOG4108MK9 spermidine N(1)-acetyltransferase HPE50_RS12810 ENOG4105KBG Protein of unknown function (DUF1161) HPE50_RS12815 ENOG4107QY8 reductase HPE50_RS12820 ENOG4105C3J Cysteine desulfurase HPE50_RS12825 ENOG4105QAX Iron-sulfur HPE50_RS12830 ENOG4107KGK dmso reductase anchor subunit HPE50_RS12835 ENOG4108NEM leader-binding protein dmsD HPE50_RS12845 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPE50_RS12850 ENOG4105DAG ROK family HPE50_RS12855 ENOG4106NZI LysR family Transcriptional regulator HPE50_RS12860 ENOG4105D94 Major Facilitator Superfamily HPE50_RS12875 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HPE50_RS12890 ENOG4105DSF transport protein HPE50_RS12895 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPE50_RS12900 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPE50_RS12905 ENOG4105C5D exported protein HPE50_RS12910 ENOG4105D5Q Arginine ornithine antiporter HPE50_RS12920 ENOG4105RA2 Membrane HPE50_RS12925 ENOG4107EXC regulatoR HPE50_RS12930 ENOG4105JJR Histidine kinase HPE50_RS12940 ENOG4105C9Q fumarate hydratase class II HPE50_RS12945 ENOG4105VNT transposase (IS4 family) protein HPE50_RS12955 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HPE50_RS12970 ENOG4105ENH Sulfatase HPE50_RS12975 ENOG4105C4X radical SAM domain protein HPE50_RS12985 ENOG4105CQ0 ABC transporter HPE50_RS12990 ENOG4105PE1 Receptor HPE50_RS12995 ENOG4107RAN Peptidase, M16 HPE50_RS13000 ENOG4105CVK Glutamate decarboxylase HPE50_RS13005 ENOG4105E5D amino acid HPE50_RS13010 ENOG4105F32 YngK protein HPE50_RS13025 ENOG4108UQS dipeptidase HPE50_RS13030 ENOG4105DEF Extracellular solute-binding protein, family 5 HPE50_RS13035 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPE50_RS13040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPE50_RS13045 ENOG4105C3U ABC transporter HPE50_RS13050 ENOG4107H6U ABC transporter HPE50_RS13055 ENOG4108Z9K Osmotically inducible protein HPE50_RS13060 ENOG4105TPS biofilm-dependent modulation protein HPE50_RS13065 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HPE50_RS13075 ENOG4105DQ4 alcohol dehydrogenase HPE50_RS13085 ENOG41084S7 Plasmid maintenance system antidote protein HPE50_RS13090 ENOG4108MG3 formate dehydrogenase HPE50_RS13095 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPE50_RS13105 ENOG4105RPH Inner membrane protein YddG HPE50_RS13120 ENOG4108UI3 Leucine Rich repeat HPE50_RS13130 ENOG4107QND Nitrite extrusion protein HPE50_RS13135 ENOG4105CRU nitrate reductase, alpha subunit HPE50_RS13140 ENOG4108IUE nitrate reductase beta subunit HPE50_RS13145 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HPE50_RS13150 ENOG4105D0D Nitrate reductase 2, gamma subunit HPE50_RS13155 ENOG4105JAB phenazine biosynthesis protein, phzf family HPE50_RS13160 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPE50_RS13165 ENOG4108MEJ flavin reductase domain protein HPE50_RS13175 ENOG4105EUZ Beta-lactamase domain protein HPE50_RS13200 ENOG4105C85 amino acid HPE50_RS13205 ENOG4108NS2 receptor HPE50_RS13210 ENOG4105CHB tonB-dependent Receptor HPE50_RS13220 ENOG4108WYP Transcriptional regulator HPE50_RS13225 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HPE50_RS13230 ENOG4108Z7F N-acetyltransferase HPE50_RS13235 ENOG4108T9Y Inner membrane protein ydcZ HPE50_RS13240 ENOG4105R71 cytoplasmic protein HPE50_RS13265 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HPE50_RS13270 ENOG4105D81 ABC transporter, permease HPE50_RS13275 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPE50_RS13280 ENOG4107TYH extracellular solute-binding protein family 1 HPE50_RS13285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPE50_RS13295 ENOG4105RR0 Protein of unknown function (DUF2554) HPE50_RS13300 ENOG4105CFP Peptidase U32 HPE50_RS13305 ENOG4108JCI Transcriptional regulator HPE50_RS13310 ENOG4105DKK Benzoate HPE50_RS13315 ENOG4108KKZ (LipO)protein HPE50_RS13320 ENOG41088CC tellurite resistance protein tehB HPE50_RS13325 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HPE50_RS13330 ENOG4107WE3 acetyltransferase YdcK HPE50_RS13335 ENOG4108Z9I -acetyltransferase HPE50_RS13340 ENOG4105Z2P Protein of unknown function (DUF465) HPE50_RS13350 ENOG4105E32 cytoplasmic protein HPE50_RS13355 ENOG4105DDW LysR family Transcriptional regulator HPE50_RS13360 ENOG4105C8Q Methyl-accepting chemotaxis HPE50_RS13365 ENOG4107NK6 Hok/gef family HPE50_RS13370 ENOG4105UPP uncharacterized protein ydcA HPE50_RS13375 ENOG4105CPW cytochrome b561 HPE50_RS13380 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPE50_RS13385 ENOG4105C26 Dehydrogenase HPE50_RS13390 ENOG4107DB1 DUF218 domain HPE50_RS13395 ENOG4105CQ7 ATP-dependent helicase HPE50_RS13405 ENOG41077RS Phosphatase HPE50_RS13410 ENOG4105E8V Alpha Beta Hydrolase Fold protein HPE50_RS13415 ENOG4108HPI phosphatidate Cytidylyltransferase HPE50_RS13420 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HPE50_RS13435 ENOG4105WXT Conserved Protein HPE50_RS13440 ENOG410689M (LipO)protein HPE50_RS13445 ENOG4107H52 Dicarboxylate transport HPE50_RS13450 ENOG4105C5I Dehydrogenase HPE50_RS13455 ENOG41090X5 Heat shock protein hslJ HPE50_RS13460 ENOG4105IKK cytoplasmic protein HPE50_RS13465 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HPE50_RS13480 ENOG4108RW8 Universal stress protein F HPE50_RS13490 ENOG4105DIK (ABC) transporter HPE50_RS13495 ENOG4105CC5 ABC transporter HPE50_RS13500 ENOG4105CC5 ABC transporter HPE50_RS13540 ENOG4107C82 Rac prophage HPE50_RS13550 ENOG41076J9 exonuclease VIII HPE50_RS13555 ENOG4108PNI recT protein HPE50_RS13560 ENOG4106YAH restriction alleviation and modification enhancement HPE50_RS13565 ENOG41070YT Rac prophage HPE50_RS13570 ENOG4107160 Rac prophage HPE50_RS13585 ENOG4105C1J atp-dependent rna helicase HPE50_RS13595 ENOG4105BZU Histidine kinase HPE50_RS13600 ENOG4108DG9 Smr protein MutS2 HPE50_RS13605 ENOG4106KR7 LysR family Transcriptional regulator HPE50_RS13610 ENOG4105CH2 amidohydrolase HPE50_RS13615 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HPE50_RS13620 ENOG4105CFC Transporter HPE50_RS13625 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPE50_RS13630 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HPE50_RS13635 ENOG4105Q9Y Universal stress protein HPE50_RS13640 ENOG4105S5I Membrane HPE50_RS13645 ENOG4105D64 Mechanosensitive ion channel HPE50_RS13650 ENOG4107QSI ABC, transporter HPE50_RS13655 ENOG4105KXI murein peptide amidase A HPE50_RS13660 ENOG4107S8C mandelate racemase muconate lactonizing HPE50_RS13665 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPE50_RS13670 ENOG4108JU8 Transcriptional regulator HPE50_RS13680 ENOG4105CM6 amino acid regulated cytosolic protein HPE50_RS13685 ENOG4105FKQ transcriptional regulator HPE50_RS13690 ENOG4107EFV Outer membrane protein G HPE50_RS13695 ENOG4108IJ9 (ABC) transporter HPE50_RS13715 ENOG4105WEM extracellular solute-binding protein HPE50_RS13720 ENOG4107QW3 Sucrose phosphorylase HPE50_RS13725 ENOG4105K8Z Phage shock protein HPE50_RS13730 ENOG4105NNG Peripheral inner membrane phage-shock protein HPE50_RS13735 ENOG4105FM1 phage shock protein C HPE50_RS13740 ENOG4105YYT phage shock protein B HPE50_RS13745 ENOG41087YS Phage shock protein A HPE50_RS13750 ENOG4105E51 psp operon transcriptional activator HPE50_RS13755 ENOG4108JPW Aminotransferase HPE50_RS13760 ENOG4105CJP fad dependent oxidoreductase HPE50_RS13765 ENOG4105C26 Dehydrogenase HPE50_RS13770 ENOG4107VRI Transcriptional regulator HPE50_RS13775 ENOG4108Z86 Glutamine amidotransferase HPE50_RS13780 ENOG4105CFQ glutamine synthetase HPE50_RS13790 ENOG4105CUB amino acid HPE50_RS13795 ENOG4105N0E Protein of unknown function (DUF2543) HPE50_RS13800 ENOG4108HIY periplasmic HPE50_RS13805 ENOG4108I5W peptide transport system, permease protein HPE50_RS13810 ENOG4108EU3 peptide transport system, permease HPE50_RS13815 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HPE50_RS13820 ENOG4108JQ2 peptide transport system atp-binding protein HPE50_RS13825 ENOG4105C2C drug resistance transporter, Bcr CflA HPE50_RS13835 ENOG4105BZS acriflavin resistance protein HPE50_RS13840 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPE50_RS13845 ENOG41067SE Tetr family transcriptional regulator HPE50_RS13850 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HPE50_RS13870 ENOG4105BZU Histidine kinase HPE50_RS13875 ENOG410643D UPF0509 protein HPE50_RS13880 ENOG4105N2W Transcriptional regulator HPE50_RS13890 ENOG4108ZJT translation initiation factor, Sui1 HPE50_RS13900 ENOG4105CFV Tetratricopeptide repeat protein HPE50_RS13905 ENOG4105Q4A inner membrane protein yciS HPE50_RS13910 ENOG4105EYK Phosphatidylglycerophosphatase B HPE50_RS13920 ENOG4107QM5 aconitate hydratase HPE50_RS13940 ENOG4107R11 Transcriptional regulator HPE50_RS13945 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPE50_RS13950 ENOG4105RKX Protein of unknown function (DUF2498) HPE50_RS13955 ENOG4105ERU peptidase HPE50_RS13960 ENOG4105UBK short-chain dehydrogenase reductase HPE50_RS13965 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HPE50_RS13985 ENOG4105FE9 pseudouridine synthase HPE50_RS13990 ENOG4105EG3 transmembrane signal peptide protein HPE50_RS13995 ENOG4107RTD sua5 ycio yrdc ywlc family protein HPE50_RS14000 ENOG4105DB7 PHP domain protein HPE50_RS14010 ENOG4105CRQ synthase (Component I) HPE50_RS14015 ENOG4108EFP Anthranilate synthase component II HPE50_RS14020 ENOG4105DK0 Indole-3-glycerol phosphate synthase HPE50_RS14040 ENOG4108Z9Z response to DNA damage stimulus HPE50_RS14055 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HPE50_RS14075 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HPE50_RS14115 ENOG4105KSK (crossover) junction endodeoxyribonuclease HPE50_RS14120 ENOG4108MXB Protein of unknown function (DUF968) HPE50_RS14140 ENOG4105WPN DNA integration recombination invertion protein HPE50_RS14155 ENOG4105JBR DNA replication protein HPE50_RS14185 ENOG4107712 HPE50_RS14200 ENOG4106G8A Qin prophage HPE50_RS14215 ENOG4108I1J Integrase HPE50_RS14220 ENOG4105EIF outer membrane protein W HPE50_RS14240 ENOG4105NAU thioesterase Superfamily protein HPE50_RS14245 ENOG410822N TonB family HPE50_RS14250 ENOG4105K9H YciI-like protein HPE50_RS14270 ENOG4105Y50 Virulence Protein HPE50_RS14285 ENOG4107SVH Potassium channel protein HPE50_RS14305 ENOG4108JQ7 (ABC) transporter HPE50_RS14310 ENOG4105C3U ABC transporter HPE50_RS14315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPE50_RS14320 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPE50_RS14325 ENOG4108J59 Extracellular solute-binding protein, family 5 HPE50_RS14335 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HPE50_RS14340 ENOG4105C0A alcohol dehydrogenase HPE50_RS14345 ENOG4105VNT transposase (IS4 family) protein HPE50_RS14350 ENOG4107104 thymidine kinase HPE50_RS14355 ENOG4108SAU DNA-binding protein H-ns HPE50_RS14360 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPE50_RS14365 ENOG4105I93 response regulator HPE50_RS14370 ENOG4105D78 K07001 NTE family protein HPE50_RS14375 ENOG4105K5B UPF0225 protein HPE50_RS14380 ENOG4105CIY formyltetrahydrofolate deformylase HPE50_RS14395 ENOG41076YT nitrate reductase, gamma subunit HPE50_RS14400 ENOG4105R3A Nitrate reductase HPE50_RS14405 ENOG4108IUE nitrate reductase beta subunit HPE50_RS14410 ENOG4105CRU nitrate reductase, alpha subunit HPE50_RS14415 ENOG4105DQQ Major facilitator superfamily MFS_1 HPE50_RS14420 ENOG4105BZU Histidine kinase HPE50_RS14425 ENOG4105WH1 Two component transcriptional regulator luxr family HPE50_RS14430 ENOG4105ID0 Putative invasin HPE50_RS14435 ENOG41090EX DsrE family HPE50_RS14440 ENOG4108NH8 Cation transport protein HPE50_RS14445 ENOG4105WS7 Cation transport regulator HPE50_RS14450 ENOG4105EWV Sodium calcium exchanger membrane region HPE50_RS14470 ENOG41063JG Transcriptional regulator HPE50_RS14475 ENOG4108YY7 Invasion gene expression up-regulator SirB HPE50_RS14480 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPE50_RS14505 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HPE50_RS14510 ENOG4105CHH sulfate transporter HPE50_RS14515 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HPE50_RS14525 ENOG4105C3G gtp-binding protein HPE50_RS14535 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HPE50_RS14540 ENOG4105CMT Dihydroxyacetone kinase HPE50_RS14545 ENOG4108UTZ Dihydroxyacetone kinase HPE50_RS14550 ENOG4105VDH Dihydroxyacetone kinase HPE50_RS14570 ENOG4105S10 periplasmic binding protein HPE50_RS14575 ENOG4105EHG Permease protein HPE50_RS14580 ENOG4105E0A ABC, transporter HPE50_RS14585 ENOG4108BSC Methyltransferase HPE50_RS14590 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPE50_RS14605 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HPE50_RS14615 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPE50_RS14635 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPE50_RS14645 ENOG4105ED1 spovr family HPE50_RS14660 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HPE50_RS14670 ENOG4105KT5 UmuD protein HPE50_RS14675 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HPE50_RS14685 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HPE50_RS14695 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HPE50_RS14700 ENOG4105S66 prophage protein HPE50_RS14710 ENOG4107QMS site-determining protein HPE50_RS14745 ENOG410658X HPE50_RS14760 ENOG4105BZU Histidine kinase HPE50_RS14765 ENOG410738I uncharacterized protein ymgC HPE50_RS14775 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HPE50_RS14780 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HPE50_RS14785 ENOG4105BZU Histidine kinase HPE50_RS14790 ENOG4108XDN Transcriptional regulator HPE50_RS14795 ENOG41064WM Uncharacterized protein YcgX HPE50_RS14810 ENOG4108HMX isocitrate dehydrogenase (NADP) HPE50_RS14825 ENOG4108R99 pseudouridine synthase HPE50_RS14845 ENOG4107QTF adenylosuccinate lyase HPE50_RS14850 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPE50_RS14855 ENOG4105IFJ Histidine kinase HPE50_RS14860 ENOG4105EZE Cupin 4 family protein HPE50_RS14870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPE50_RS14880 ENOG4105D38 putrescine abc transporter HPE50_RS14885 ENOG4107RUE extracellular solute-binding protein family 1 HPE50_RS14900 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPE50_RS14910 ENOG4105D60 lipoprotein releasing system transmembrane protein HPE50_RS14915 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPE50_RS14920 ENOG4105D60 lipoprotein releasing system transmembrane protein HPE50_RS14925 ENOG4105IQC Inner membrane protein YcfT HPE50_RS14930 ENOG4108JA2 transcriptioN-repair coupling factor HPE50_RS14935 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPE50_RS14940 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HPE50_RS14945 ENOG4108IND Tetr family transcriptional regulator HPE50_RS14950 ENOG4107MBR 17 kDa surface antigen HPE50_RS14955 ENOG4105CEP NADH dehydrogenase HPE50_RS14975 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HPE50_RS14980 ENOG41090DQ Lipoprotein HPE50_RS14985 ENOG4105K59 histidine triad (HIT) protein HPE50_RS14990 ENOG4105CNM Receptor HPE50_RS14995 ENOG4105CI1 PTS System HPE50_RS15000 ENOG4105F8V Hydrolase, tatD family HPE50_RS15005 ENOG4107QRG dna polymerase iii HPE50_RS15015 ENOG4105HHA aminodeoxychorismate lyase HPE50_RS15020 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HPE50_RS15025 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPE50_RS15030 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPE50_RS15035 ENOG4105CHR reductase HPE50_RS15040 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPE50_RS15060 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HPE50_RS15065 ENOG4108UHJ MAF-like protein HPE50_RS15070 ENOG4105EI2 Pseudouridine synthase HPE50_RS15075 ENOG4107QQB Ribonuclease E HPE50_RS15090 ENOG4105DTJ flagellar hook-associated protein HPE50_RS15095 ENOG4105E1Q flagellar hook-associated protein HPE50_RS15100 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HPE50_RS15105 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HPE50_RS15115 ENOG4105CGA flagellar basal-body rod protein FlgG HPE50_RS15120 ENOG4108KPB Flagellar basal-body rod protein FlgF HPE50_RS15125 ENOG4105BZE flagellar hook protein, FlgE HPE50_RS15130 ENOG4105W00 Flagellar hook capping protein HPE50_RS15135 ENOG4108ZC9 flagellar basal-body rod protein flgc HPE50_RS15140 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPE50_RS15145 ENOG4105CKS Flagella basal body P-ring formation protein flgA HPE50_RS15150 ENOG4105M9M anti-sigma28 factor FlgM HPE50_RS15155 ENOG4105QVD Flagella synthesis protein FlgN HPE50_RS15160 ENOG4105CJR Integral membrane protein (MviN HPE50_RS15165 ENOG4105EP9 oxidoreductase HPE50_RS15175 ENOG4105D9U N-acetyltransferase HPE50_RS15185 ENOG4105E9S glutaredoxin 2 HPE50_RS15190 ENOG4105F3T (LipO)protein HPE50_RS15205 ENOG4105PVA Biofilm formation regulatory protein BssS HPE50_RS15210 ENOG4105F76 Sarcosine oxidase HPE50_RS15215 ENOG4106974 biofilm formation HPE50_RS15220 ENOG4105DS1 cytochrome b561 HPE50_RS15225 ENOG4108YYC ycei family HPE50_RS15235 ENOG4105D1S lipid A biosynthesis HPE50_RS15245 ENOG4108W47 Acidic protein msyB HPE50_RS15250 ENOG4105NAC (LipO)protein HPE50_RS15255 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HPE50_RS15270 ENOG4107RZC phospholipase d HPE50_RS15275 ENOG4108UVJ appr-1-p processing domain protein HPE50_RS15290 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HPE50_RS15295 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HPE50_RS15300 ENOG41086KC Transcriptional regulator HPE50_RS15305 ENOG4108XDW curli assembly protein CsgE HPE50_RS15310 ENOG4108WYR Curli production assembly transport component, CsgF HPE50_RS15315 ENOG4105P8Q Curli production assembly transport component CsgG HPE50_RS15320 ENOG4108UQ5 membrane protein YcdZ HPE50_RS15325 ENOG4107XHZ cytoplasmic chaperone TorD family protein HPE50_RS15335 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HPE50_RS15350 ENOG4105D5M phosphate starvation-inducible protein HPE50_RS15355 ENOG4105DBE peroxidase HPE50_RS15370 ENOG4105CK7 Sodium proline symporter HPE50_RS15380 ENOG4105C26 Dehydrogenase HPE50_RS15385 ENOG4108R86 Transcriptional regulator HPE50_RS15390 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HPE50_RS15420 ENOG4105C2W permease HPE50_RS15425 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HPE50_RS15435 ENOG4105XH3 HPE50_RS15440 ENOG4105D6F Phosphatase HPE50_RS15460 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HPE50_RS15465 ENOG4107QY8 reductase HPE50_RS15470 ENOG4105CUW cytochrome C-TYPE protein HPE50_RS15475 ENOG4106WF9 DNA-binding transcriptional regulator TorR HPE50_RS15480 ENOG4108SV3 Tmao reductase system periplasmic protein tort HPE50_RS15485 ENOG4105BZU Histidine kinase HPE50_RS15490 ENOG4105HEE Binding Domain protein HPE50_RS15495 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HPE50_RS15510 ENOG4105VEQ Cold shock protein HPE50_RS15515 ENOG41060EU Cold shock-like protein HPE50_RS15520 ENOG4105D6F Phosphatase HPE50_RS15530 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPE50_RS15535 ENOG4105C4M (Ubiquinol oxidase) subunit I HPE50_RS15540 ENOG4105MVP hydrogenase-1 operon protein HyaF HPE50_RS15545 ENOG4108VXY Hydrogenase-1 operon protein HyaE HPE50_RS15550 ENOG4108USZ hydrogenase HPE50_RS15555 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HPE50_RS15560 ENOG4105DPX Hydrogenase, large subunit HPE50_RS15565 ENOG4105E3S small subunit HPE50_RS15575 ENOG4108MN8 Membrane HPE50_RS15580 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HPE50_RS15585 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HPE50_RS15600 ENOG4105K4P CoA-binding domain protein HPE50_RS15615 ENOG41088T4 Helicase IV HPE50_RS15620 ENOG410901E Membrane HPE50_RS15625 ENOG4105EM2 membrane HPE50_RS15630 ENOG4108RZ1 DNA transformation protein HPE50_RS15640 ENOG4105UYK outer membrane protein a HPE50_RS15650 ENOG4105DAN ATP-dependent protease HPE50_RS15660 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HPE50_RS15665 ENOG4108Q2G (LipO)protein HPE50_RS15670 ENOG4105DY2 Paraquat-inducible protein b HPE50_RS15675 ENOG4105F1S paraquat-inducible protein a HPE50_RS15680 ENOG4105C5H ABC transporter HPE50_RS15690 ENOG4105QVC MOSC domain-containing protein HPE50_RS15695 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HPE50_RS15705 ENOG4106PH7 chaperone HPE50_RS15710 ENOG4105MX3 Fimbrial HPE50_RS15715 ENOG4105Q7J Fimbrial HPE50_RS15720 ENOG4108MDY Fimbrial HPE50_RS15725 ENOG4105CW0 outer membrane usher protein HPE50_RS15740 ENOG4108UZX fmn reductase HPE50_RS15745 ENOG4105GVF (ABC) transporter HPE50_RS15755 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPE50_RS15760 ENOG4105E2Y ABC, transporter HPE50_RS15765 ENOG4105CD8 aminopeptidase N HPE50_RS15780 ENOG4105FCK Membrane HPE50_RS15785 ENOG4105CGF Aromatic amino acid aminotransferase HPE50_RS15790 ENOG4105C5X domain protein HPE50_RS15795 ENOG4105EAQ (twin-arginine translocation) pathway signal HPE50_RS15800 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HPE50_RS15810 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HPE50_RS15820 ENOG4106371 Methyltransferase HPE50_RS15825 ENOG4107S90 membrAne HPE50_RS15830 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HPE50_RS15845 ENOG4105T0Z Conserved Protein HPE50_RS15855 ENOG4105BZ1 (ABC) transporter HPE50_RS15860 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HPE50_RS15870 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HPE50_RS15880 ENOG4108K0D peptidase, M48 HPE50_RS15885 ENOG4105VNT transposase (IS4 family) protein HPE50_RS15900 ENOG4107VMU Membrane HPE50_RS15905 ENOG4105DDY UPF0142 protein ycaO HPE50_RS15910 ENOG4105TMB Formate nitrite transporter HPE50_RS15915 ENOG4105C6N Formate acetyltransferase HPE50_RS15920 ENOG4105F1A Pyruvate formate-lyase HPE50_RS15925 ENOG4105EJG cellulose synthase HPE50_RS15945 ENOG4107QZ7 Cellulose synthase catalytic subunit HPE50_RS15950 ENOG41064RH membrane protein YliF HPE50_RS15955 ENOG4105BZU Histidine kinase HPE50_RS15970 ENOG4105CHJ isochorismatase hydrolase HPE50_RS15975 ENOG4107KGK dmso reductase anchor subunit HPE50_RS15980 ENOG4105QAX Iron-sulfur HPE50_RS15985 ENOG4107QY8 reductase HPE50_RS15990 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPE50_RS16060 ENOG4105VZ1 Replication Protein HPE50_RS16090 ENOG4105ED4 portal protein HPE50_RS16175 ENOG4108X9F tail fiber protein HPE50_RS16175 ENOG4108X9F tail fiber protein HPE50_RS16180 ENOG4105UZW Tail fiber assembly protein HPE50_RS16220 ENOG4105ZTC transcriptional activator, Ogr delta HPE50_RS16235 ENOG4105D1H recombination factor protein RarA HPE50_RS16245 ENOG4105CNU cell division protein FtsK HPE50_RS16255 ENOG4105C3M thioredoxin reductase HPE50_RS16260 ENOG4108JJ9 ABC, transporter HPE50_RS16265 ENOG4108JJ8 (ABC) transporter HPE50_RS16275 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPE50_RS16285 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPE50_RS16315 ENOG4105IM0 capsid protein HPE50_RS16370 ENOG4105VEQ Cold shock protein HPE50_RS16375 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPE50_RS16380 ENOG4105DJY efflux transporter, rnd family, mfp subunit HPE50_RS16385 ENOG4108MJ5 VirK protein HPE50_RS16390 ENOG4105CPB ATP-dependent endonuclease of the OLD family HPE50_RS16395 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPE50_RS16400 ENOG4105EQR Transposase IS116 IS110 IS902 HPE50_RS16405 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HPE50_RS16410 ENOG4105MSY salicylate hydroxylase HPE50_RS16415 ENOG4108RXX maleylacetoacetate isomerase HPE50_RS16445 ENOG41067MG lrgb family HPE50_RS16455 ENOG4107GZ4 SanA protein HPE50_RS16460 ENOG4105Y9N Membrane HPE50_RS16465 ENOG4105BZ8 glutamate synthase HPE50_RS16470 ENOG4107SJI Dehydrogenase HPE50_RS16475 ENOG4108HWV )-transporter HPE50_RS16480 ENOG4105C2J ABC transporter HPE50_RS16485 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HPE50_RS16490 ENOG41060NJ transcriptional regulator HPE50_RS16495 ENOG4105DHF Membrane HPE50_RS16515 ENOG4108IQI permease HPE50_RS16520 ENOG4105DUM transcriptional regulator, lysR family HPE50_RS16525 ENOG4105HMI Membrane HPE50_RS16535 ENOG4105DD7 kinase (PfkB family HPE50_RS16540 ENOG4105D9N nucleoside HPE50_RS16555 ENOG4108Y4K DNA-binding transcriptional activator HPE50_RS16560 ENOG4105D9N nucleoside HPE50_RS16565 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HPE50_RS16570 ENOG4105DD7 kinase (PfkB family HPE50_RS16575 ENOG4105DM4 PTS System HPE50_RS16580 ENOG4105DE4 1-phosphofructokinase HPE50_RS16585 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HPE50_RS16590 ENOG4105S8Q sugar efflux transporter HPE50_RS16595 ENOG4105KRS Proteinase inhibitor HPE50_RS16605 ENOG4105DEI Mannitol dehydrogenase HPE50_RS16610 ENOG4105CKI cobalamin synthesis protein HPE50_RS16615 ENOG41076MN Phosphoesterase, PA-phosphatase related HPE50_RS16620 ENOG4107TT5 NLP P60 protein HPE50_RS16625 ENOG4105CXC rtn protein HPE50_RS16630 ENOG4105E43 Extracellular solute-binding protein, family 5 HPE50_RS16635 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HPE50_RS16645 ENOG4108JQ5 ABC transporter HPE50_RS16650 ENOG4105HG6 HPE50_RS16655 ENOG4105C2C drug resistance transporter, Bcr CflA HPE50_RS16660 ENOG4105I08 Pseudouridine synthase HPE50_RS16665 ENOG4105CFI type iii restriction protein res subunit HPE50_RS16685 ENOG4105E68 Sulfatase HPE50_RS16695 ENOG4105VNT transposase (IS4 family) protein HPE50_RS16700 ENOG4108MGN ATP-binding component of a transport system HPE50_RS16710 ENOG4105WH1 Two component transcriptional regulator luxr family HPE50_RS16715 ENOG4105KWW Biogenesis protein HPE50_RS16720 ENOG4107QX9 Thiol disulfide interChange protein HPE50_RS16725 ENOG4105DA4 cytochrome c-type biogenesis protein HPE50_RS16735 ENOG4105X3C heme exporter protein HPE50_RS16740 ENOG41060IM Heme exporter protein HPE50_RS16745 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPE50_RS16750 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPE50_RS16755 ENOG4105CUW cytochrome C-TYPE protein HPE50_RS16760 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HPE50_RS16765 ENOG4105GXZ Ferredoxin-type protein NapH HPE50_RS16770 ENOG4108BGM Quinol dehydrogenase periplasmic component HPE50_RS16780 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HPE50_RS16785 ENOG4108ZNS ferredoxin-type protein NapF HPE50_RS16805 ENOG4105IBP Cyclic peptide transporter HPE50_RS16810 ENOG4105CF1 Alkylated DNA repair protein HPE50_RS16815 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPE50_RS16820 ENOG4105CJ2 (LipO)protein HPE50_RS16825 ENOG4105FCK Membrane HPE50_RS16830 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HPE50_RS16835 ENOG41068CG regulatoR HPE50_RS16840 ENOG4105BZU Histidine kinase HPE50_RS16860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPE50_RS16865 ENOG4107QP7 CoA-transferase subunit A HPE50_RS16870 ENOG4107QNJ CoA-transferase subunit B HPE50_RS16875 ENOG4105CRW Short chain fatty acid transporter HPE50_RS16880 ENOG4105CHU acetyl-coa acetyltransferase HPE50_RS16885 ENOG4105EDV vault protein HPE50_RS16890 ENOG41081SK signal peptide protein HPE50_RS16895 ENOG4107S52 alpha-2-macroglobulin domain protein HPE50_RS16900 ENOG4108QJJ Protein of unknown function (DUF1175) HPE50_RS16905 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HPE50_RS16910 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPE50_RS16915 ENOG4105CXK mandelate racemase muconate lactonizing HPE50_RS16925 ENOG4105DRR Transcriptional regulator, GntR family HPE50_RS16935 ENOG4107GHC outer membrane autotransporter HPE50_RS16940 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPE50_RS16945 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPE50_RS16950 ENOG4105XPH Ferredoxin HPE50_RS16955 ENOG4105FQR PH-inducible protein involved in stress response HPE50_RS16960 ENOG4105CZM Major Facilitator HPE50_RS16965 ENOG4105GZI Transcriptional regulator HPE50_RS16970 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HPE50_RS16975 ENOG4105CXY transporter HPE50_RS16980 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HPE50_RS16990 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPE50_RS16995 ENOG4105DNE Transposase HPE50_RS17010 ENOG4105CSP Major Facilitator Superfamily HPE50_RS17020 ENOG4107258 Transcriptional regulator HPE50_RS17025 ENOG4108EWA cinA-like protein HPE50_RS17030 ENOG4108UII YfaZ family HPE50_RS17080 ENOG4106GZG polymyxin resistance protein B HPE50_RS17085 ENOG4105CEY Amp-dependent synthetase and ligase HPE50_RS17095 ENOG4108IPT Naphthoate synthase HPE50_RS17110 ENOG4105E4F Isochorismate synthase HPE50_RS17115 ENOG4105TNS Conserved Protein HPE50_RS17120 ENOG4107YB6 acetyltransferase, (GNAT) family HPE50_RS17130 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is HPE50_RS17135 ENOG4107VAM peptidase, m28 HPE50_RS17140 ENOG4105GDX Domain of unknown function (DUF1877) HPE50_RS17150 ENOG4105C8S subunit m HPE50_RS17155 ENOG4105D65 subunit l HPE50_RS17165 ENOG4107UFS subunit j HPE50_RS17180 ENOG4108IEH NADH dehydrogenase subunit g HPE50_RS17185 ENOG4107QIZ NADH dehydrogenase HPE50_RS17190 ENOG4105GKE subunit e HPE50_RS17210 ENOG4107NQ8 LysR family Transcriptional regulator HPE50_RS17215 ENOG4105CHM Aminotransferase HPE50_RS17225 ENOG4107QWE )-transporter HPE50_RS17230 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HPE50_RS17235 ENOG4105XWI UPF0304 protein HPE50_RS17245 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPE50_RS17250 ENOG4105C6K Malic enzyme HPE50_RS17255 ENOG4105CSX c4-dicarboxylate anaerobic carrier HPE50_RS17260 ENOG4105PTV Nudix Hydrolase HPE50_RS17265 ENOG4108RE9 Phosphodiesterase HPE50_RS17270 ENOG4108SHQ Glutathione S-transferase HPE50_RS17275 ENOG4105CYM Glutathione S-transferase HPE50_RS17280 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HPE50_RS17285 ENOG4105ECP epimerase HPE50_RS17290 ENOG4105DFD Na H antiporter HPE50_RS17300 ENOG4105DNE Transposase HPE50_RS17305 ENOG4108JEH abc transporter atp-binding protein HPE50_RS17310 ENOG4106YG3 ABC transporter HPE50_RS17315 ENOG4105DSP amino acid AbC transporter HPE50_RS17320 ENOG4105E89 ABC transporter HPE50_RS17325 ENOG4105E89 ABC transporter HPE50_RS17330 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPE50_RS17335 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HPE50_RS17340 ENOG4105E96 Colicin v production protein HPE50_RS17345 ENOG4108S3P Sporulation domain protein HPE50_RS17350 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPE50_RS17360 ENOG4105DQR SNARE associated Golgi HPE50_RS17370 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPE50_RS17380 ENOG4106WZ1 flagella biosynthesis regulator HPE50_RS17385 ENOG4105F9N Major Facilitator Superfamily HPE50_RS17390 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPE50_RS17400 ENOG4105MH2 YfcL protein HPE50_RS17405 ENOG4108BPE -transporting atpase HPE50_RS17410 ENOG4105EJ9 Membrane HPE50_RS17420 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HPE50_RS17425 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HPE50_RS17450 ENOG4105US4 fimbrial-like protein yfcP HPE50_RS17455 ENOG4105UGQ Fimbrial HPE50_RS17460 ENOG4105NEV Fimbrial HPE50_RS17465 ENOG4108FZ9 Chaperone HPE50_RS17470 ENOG4106PG1 outer membrane usher protein HPE50_RS17480 ENOG4108BY2 phosphohistidine phosphatase HPE50_RS17495 ENOG4105KZW UPF0381 protein HPE50_RS17500 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HPE50_RS17520 ENOG410903C (LipO)protein HPE50_RS17525 ENOG4105S64 Formate nitrite transporter HPE50_RS17535 ENOG4105W8I Transcriptional regulator HPE50_RS17550 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPE50_RS17555 ENOG4105CW7 secretion protein, HlyD family HPE50_RS17560 ENOG4108WQH regulatoR HPE50_RS17565 ENOG4105BZU Histidine kinase HPE50_RS17570 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPE50_RS17575 ENOG4108N2Y auxin Efflux HPE50_RS17580 ENOG4105CFN oxalyl-CoA decarboxylase HPE50_RS17590 ENOG4108V08 YfdX protein HPE50_RS17600 ENOG4105W9M Membrane HPE50_RS17605 ENOG4105D1S lipid A biosynthesis HPE50_RS17615 ENOG4105CHM Aminotransferase HPE50_RS17620 ENOG4108HRK Histidine kinase HPE50_RS17625 ENOG4105DY9 regulatoR HPE50_RS17630 ENOG4108CIP transcriptional regulator HPE50_RS17635 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPE50_RS17640 ENOG4105CN9 Peptidase m42 family protein HPE50_RS17645 ENOG4105DC7 peptidase M24 HPE50_RS17650 ENOG410863U PTS System HPE50_RS17655 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HPE50_RS17670 ENOG4109076 Conserved Protein HPE50_RS17680 ENOG4105D9N nucleoside HPE50_RS17685 ENOG4105VNT transposase (IS4 family) protein HPE50_RS17690 ENOG4108KMM Diguanylate cyclase HPE50_RS17705 ENOG4105HZG regulatoR HPE50_RS17710 ENOG4105GXM Putative transcription regulator (DUF1323) HPE50_RS17715 ENOG4105D7V transposase HPE50_RS17725 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HPE50_RS17745 ENOG4105CN8 Transcriptional regulator HPE50_RS17755 ENOG4105EAA nucleoside HPE50_RS17760 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HPE50_RS17765 ENOG4108NFH Sugar hydrolase HPE50_RS17770 ENOG4108M0I Transcriptional regulator HPE50_RS17775 ENOG4105DHU Bile acid HPE50_RS17780 ENOG4105VRT cytoplasmic protein HPE50_RS17800 ENOG4105C6T cysteine synthase HPE50_RS17810 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPE50_RS17815 ENOG4105C5Y PTS System HPE50_RS17825 ENOG4105M0Y HPE50_RS17830 ENOG4105C6T cysteine synthase HPE50_RS17835 ENOG4108IJ6 ABC transporter HPE50_RS17840 ENOG4105ECW sulfate abc transporter HPE50_RS17845 ENOG4108I5D sulfate abc transporter HPE50_RS17850 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HPE50_RS17855 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HPE50_RS17870 ENOG4105C5Y PTS System HPE50_RS17875 ENOG4107S1E Beta-lactamase HPE50_RS17880 ENOG4105EZR dyp-type peroxidase family protein HPE50_RS17885 ENOG4105E7K (LipO)protein HPE50_RS17890 ENOG4105QZU Inner membrane protein YfeZ HPE50_RS17900 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HPE50_RS17910 ENOG4108K3Z AraC family transcriptional regulator HPE50_RS17915 ENOG4108X49 Ethanolamine utilization protein EutK HPE50_RS17920 ENOG4106D67 ethanolamine utilization protein HPE50_RS17930 ENOG4105CPD ethanolamine ammonia-lyase HPE50_RS17935 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HPE50_RS17940 ENOG4105ENY Ethanolamine utilization protein eutH HPE50_RS17945 ENOG4105C0A alcohol dehydrogenase HPE50_RS17950 ENOG4107RWI ethanolamine utilization protein eutJ HPE50_RS17955 ENOG4108EKI Dehydrogenase HPE50_RS17960 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HPE50_RS17965 ENOG4105KNY Microcompartments protein HPE50_RS17970 ENOG4107WUY phosphate acetyltransferase HPE50_RS17975 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HPE50_RS17980 ENOG4105NDK ethanolamine utilization protein HPE50_RS17985 ENOG4106S4J ethanolamine utilization protein EutP HPE50_RS17995 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HPE50_RS18000 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HPE50_RS18005 ENOG4105C6K Malic enzyme HPE50_RS18010 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPE50_RS18015 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPE50_RS18020 ENOG4108PVD exported protein HPE50_RS18030 ENOG4105BZ8 glutamate synthase HPE50_RS18035 ENOG4105BZU Histidine kinase HPE50_RS18040 ENOG4105BZS acriflavin resistance protein HPE50_RS18050 ENOG4105KUZ arsenate reductase HPE50_RS18065 ENOG4106KED esterase YpfH HPE50_RS18075 ENOG4105CGZ zinc metallopeptidase HPE50_RS18085 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPE50_RS18095 ENOG4105RH4 Glycine cleavage system transcriptional repressor HPE50_RS18100 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPE50_RS18105 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HPE50_RS18110 ENOG4108JPZ Monovalent cation H antiporter subunit D HPE50_RS18115 ENOG4107TDF Formate hydrogenlyase subunit 4 HPE50_RS18120 ENOG4105D65 subunit l HPE50_RS18125 ENOG4107WQX hydrogenase 4 membrane subunit HPE50_RS18130 ENOG4108JPZ Monovalent cation H antiporter subunit D HPE50_RS18135 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPE50_RS18145 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HPE50_RS18150 ENOG4105I6X formate hydrogenlyase maturation HPE50_RS18155 ENOG4108JUA Transcriptional regulator HPE50_RS18160 ENOG4105TMB Formate nitrite transporter HPE50_RS18165 ENOG4105C02 permease HPE50_RS18170 ENOG4105ERG peptidase m48, ste24p HPE50_RS18175 ENOG4105K89 arsenate reductase HPE50_RS18180 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HPE50_RS18185 ENOG4105C2W permease HPE50_RS18200 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPE50_RS18205 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HPE50_RS18210 ENOG4105C9X ppx gppa phosphatase HPE50_RS18215 ENOG4105BZU Histidine kinase HPE50_RS18225 ENOG41062G3 Protein of unknown function (DUF2633) HPE50_RS18230 ENOG4108ZMA Outer membrane lipoprotein HPE50_RS18235 ENOG41066DY Membrane HPE50_RS18240 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPE50_RS18245 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPE50_RS18270 ENOG4105VPD cellular component movement HPE50_RS18285 ENOG4105N21 Membrane HPE50_RS18315 ENOG4108JQB penicillin-binding protein 1C HPE50_RS18320 ENOG4105DN3 alpha-2-macroglobulin domain protein HPE50_RS18325 ENOG4105KHC sulfurtransferase HPE50_RS18335 ENOG4105YYA enhanced serine sensitivity protein SseB HPE50_RS18345 ENOG4105WVQ Fe-S assembly protein IscX HPE50_RS18350 ENOG4108ZIT Ferredoxin, 2FE-2S HPE50_RS18370 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HPE50_RS18390 ENOG4105ECY inositol monophosphatase HPE50_RS18395 ENOG4107XM9 (LipO)protein HPE50_RS18400 ENOG4108MN2 Stationary phase inducible protein CsiE HPE50_RS18405 ENOG4105D8G Major Facilitator superfamily HPE50_RS18410 ENOG4108W5M transcriptional regulator HPE50_RS18415 ENOG4105FUY alpha subunit HPE50_RS18445 ENOG4108SB3 DoxX Family HPE50_RS18450 ENOG4108ZKT aldose 1-epimerase HPE50_RS18455 ENOG4105CPQ Dehydrogenase HPE50_RS18460 ENOG4105CNN ABC, transporter HPE50_RS18465 ENOG4108F37 ATP-binding component of a transport system HPE50_RS18470 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HPE50_RS18475 ENOG4107HQ7 repeat protein HPE50_RS18480 ENOG4108NZE NAGC-like transcriptional regulator HPE50_RS18490 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPE50_RS18500 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPE50_RS18505 ENOG4108SKK alpha helix protein HPE50_RS18510 ENOG4107WP9 Histidine kinase HPE50_RS18515 ENOG4108ETH Formylglycinamide ribotide synthetase HPE50_RS18525 ENOG4108Z6B deaminase HPE50_RS18530 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HPE50_RS18535 ENOG4106G6Q Transcriptional regulator HPE50_RS18540 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HPE50_RS18555 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HPE50_RS18575 ENOG4105C3F Signal peptidase i HPE50_RS18585 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HPE50_RS18590 ENOG4105VQK sigma E regulatory protein, MucB RseB HPE50_RS18595 ENOG41069PW sigma-e factor negative regulatory protein HPE50_RS18600 ENOG4105EMN RNA polymerase sigma factor HPE50_RS18610 ENOG4108IYU L-aspartate oxidase HPE50_RS18620 ENOG4105C1J atp-dependent rna helicase HPE50_RS18625 ENOG41090KR LysR family transcriptional Regulator HPE50_RS18645 ENOG4105EIB trna rrna methyltransferase HPE50_RS18650 ENOG4105K63 Thioredoxin HPE50_RS18655 ENOG4106IUH DTW domain containing protein HPE50_RS18660 ENOG4105CD5 CoA-binding domain protein HPE50_RS18665 ENOG4105JIM Phosphatidylserine synthase HPE50_RS18670 ENOG4105T42 (LipO)protein HPE50_RS18675 ENOG4105CSH Transporter HPE50_RS18700 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPE50_RS18705 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPE50_RS18710 ENOG4105C34 Pseudouridine synthase HPE50_RS18715 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPE50_RS18720 ENOG4105VNT transposase (IS4 family) protein HPE50_RS18725 ENOG4105HA9 of methanol dehydrogenase type HPE50_RS18735 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPE50_RS18740 ENOG4108CWB sugar kinase ygcE HPE50_RS18745 ENOG4108ITV Inner membrane protein yqcE HPE50_RS18750 ENOG4105CHR reductase HPE50_RS18755 ENOG4107R3A FAD linked oxidase domain protein HPE50_RS18760 ENOG4105C54 Major Facilitator superfamily HPE50_RS18765 ENOG4106IKH Electron transfer flavoprotein HPE50_RS18770 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HPE50_RS18775 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HPE50_RS18780 ENOG4105WQV ferredoxin-like protein HPE50_RS18785 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPE50_RS18790 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HPE50_RS18810 ENOG4107635 Hok Gef family protein HPE50_RS18815 ENOG4105DTT CRISPR-associated helicase, cas3 HPE50_RS18820 ENOG4105CYR Crispr-associated protein, cse1 family HPE50_RS18830 ENOG41060M0 Crispr-associated protein, cse4 family HPE50_RS18835 ENOG4108VWQ crispr-associated protein HPE50_RS18845 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HPE50_RS18850 ENOG4105PWE CRISPR-associated protein cas2 HPE50_RS18855 ENOG4108MXK alkaline phosphatase isozyme conversion HPE50_RS18875 ENOG4105N0Z inner membrane protein ygbE HPE50_RS18910 ENOG4108K5P (LipO)protein HPE50_RS18915 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPE50_RS18925 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPE50_RS18930 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPE50_RS18935 ENOG4105KZM cytoplasmic protein HPE50_RS18940 ENOG4105C6Z Gluconate HPE50_RS18945 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPE50_RS18950 ENOG4105FB2 class II Aldolase HPE50_RS18955 ENOG4105G63 Type III effector Hrp-dependent HPE50_RS18960 ENOG4105ZXK Dehydrogenase HPE50_RS18965 ENOG4105MVE transcriptional regulator HPE50_RS18970 ENOG4105MEW serine threonine protein phosphatase HPE50_RS18985 ENOG4105VXR cytoplasmic protein HPE50_RS18995 ENOG4108JUA Transcriptional regulator HPE50_RS19000 ENOG4105C45 hydrogenase expression formation protein (HypE) HPE50_RS19005 ENOG4105CQS hydrogenase expression formation protein HypD HPE50_RS19010 ENOG41083WG hydrogenase assembly chaperone HPE50_RS19015 ENOG4107RSS Hydrogenase accessory protein HypB HPE50_RS19020 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HPE50_RS19025 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HPE50_RS19030 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HPE50_RS19035 ENOG4107R30 NADH dehydrogenase HPE50_RS19040 ENOG4107TDF Formate hydrogenlyase subunit 4 HPE50_RS19045 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPE50_RS19050 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HPE50_RS19055 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HPE50_RS19060 ENOG4105I6X formate hydrogenlyase maturation HPE50_RS19065 ENOG4108MG9 hydrogenase 3 maturation protease HPE50_RS19075 ENOG4105CS2 ec 3.2.1.21 HPE50_RS19080 ENOG4105C5Y PTS System HPE50_RS19085 ENOG4105DDV Transcriptional regulator (LacI family HPE50_RS19090 ENOG4108RC0 Electron transport protein HPE50_RS19095 ENOG4105C8H hydrogenase maturation protein Hypf HPE50_RS19110 ENOG4108JUA Transcriptional regulator HPE50_RS19115 ENOG4105C2X Arabinose 5-phosphate isomerase HPE50_RS19120 ENOG410804X Transcriptional regulator HPE50_RS19125 ENOG4105J92 DNA-binding transcriptional activator GutM HPE50_RS19130 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HPE50_RS19135 ENOG4105VI0 Pts system, glucitol sorbitol-specific HPE50_RS19140 ENOG4105DZY Pts system, glucitol sorbitol-specific HPE50_RS19145 ENOG410787A Pts system, glucitol sorbitol-specific HPE50_RS19150 ENOG4105CVE Lytic murein transglycosylase HPE50_RS19155 ENOG4107TH8 cina domain protein HPE50_RS19175 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HPE50_RS19205 ENOG4107VXZ Hydrolase HPE50_RS19210 ENOG4105W39 Membrane HPE50_RS19225 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPE50_RS19230 ENOG4105CW7 secretion protein, HlyD family HPE50_RS19235 ENOG4105NTK Transcriptional repressor Mpra HPE50_RS19240 ENOG4105ZED uncharacterized protein ygaH HPE50_RS19245 ENOG4108UMN azlc family HPE50_RS19255 ENOG4105GIJ Glycine betaine HPE50_RS19260 ENOG4108HQS Glycine betaine HPE50_RS19265 ENOG4108IJ7 Glycine betaine HPE50_RS19270 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPE50_RS19275 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPE50_RS19285 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HPE50_RS19290 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPE50_RS19295 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPE50_RS19300 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HPE50_RS19305 ENOG4108WMJ Protein of unknown function (DUF2002) HPE50_RS19310 ENOG4108RNS Exports L-alanine (By similarity) HPE50_RS19315 ENOG4108X73 DNA- binding protein HPE50_RS19320 ENOG4108V62 Rhodanese domain protein HPE50_RS19325 ENOG41080HT Transcriptional regulator, arsr family HPE50_RS19330 ENOG4105VPI YqaE family transport protein HPE50_RS19335 ENOG4109066 lysm domain bon superfamily protein HPE50_RS19340 ENOG4108PVQ transcriptional regulator HPE50_RS19345 ENOG4105C85 amino acid HPE50_RS19350 ENOG4108JPW Aminotransferase HPE50_RS19355 ENOG4105C26 Dehydrogenase HPE50_RS19360 ENOG4105D5U fad dependent oxidoreductase HPE50_RS19370 ENOG4105E54 alpha-amylase HPE50_RS19395 ENOG4108MGN ATP-binding component of a transport system HPE50_RS19450 ENOG4105DFP Integrase HPE50_RS19460 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPE50_RS19495 ENOG4105KSC Transcriptional regulator, TraR DksA family HPE50_RS19505 ENOG4105DFE Dna adenine methylase HPE50_RS19510 ENOG4105VZ1 Replication Protein HPE50_RS19545 ENOG4105ED4 portal protein HPE50_RS19635 ENOG4108C33 Resolvase HPE50_RS19675 ENOG4105ZTC transcriptional activator, Ogr delta HPE50_RS19680 ENOG4107QJE Chromosome Partitioning Protein HPE50_RS19695 ENOG4108Z1B Cyclase dehydrase HPE50_RS19705 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPE50_RS19710 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPE50_RS19730 ENOG4108JU6 CBS domain protein HPE50_RS19735 ENOG4106KVJ cytochrome C assembly protein HPE50_RS19740 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HPE50_RS19765 ENOG41090EK ompa motb domain protein HPE50_RS19770 ENOG4108KHX Diguanylate cyclase HPE50_RS19775 ENOG4108WS1 HPE50_RS19780 ENOG4105QP9 Protein of unknown function (DUF2799) HPE50_RS19785 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPE50_RS19790 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HPE50_RS19795 ENOG4105CQC Prephenate dehydratase HPE50_RS19805 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HPE50_RS19810 ENOG4105VNT transposase (IS4 family) protein HPE50_RS19825 ENOG4105DXN mazG family HPE50_RS19830 ENOG4105MZG transcriptional modulator of maze toxin, mazf HPE50_RS19835 ENOG4106A2Z transcriptional regulator antitoxin, MazE HPE50_RS19840 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPE50_RS19850 ENOG4105BZU Histidine kinase HPE50_RS19855 ENOG4105EQX glucarate dehydratase HPE50_RS19860 ENOG4105EQX glucarate dehydratase HPE50_RS19865 ENOG4105DJB Major Facilitator Superfamily HPE50_RS19870 ENOG4105QDK Flavodoxin HPE50_RS19875 ENOG4105DR9 pseudouridine synthase HPE50_RS19880 ENOG4105WP7 tRNA pseudouridine synthase C HPE50_RS19895 ENOG4105EWT decarboxylase family HPE50_RS19900 ENOG4105C44 Serine transporter HPE50_RS19905 ENOG4105EJQ L-serine dehydratase HPE50_RS19915 ENOG4105C0A alcohol dehydrogenase HPE50_RS19920 ENOG4107W7X Aldolase HPE50_RS19925 ENOG4105EDR glucose galactose transporter HPE50_RS19930 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HPE50_RS19935 ENOG4105CMG Carbohydrate kinase HPE50_RS19945 ENOG4107EDW L-fucose operon activator HPE50_RS19955 ENOG4105M08 Membrane HPE50_RS19960 ENOG4105ETT transcriptional Regulator, LysR family HPE50_RS19965 ENOG4105M5B (LipO)protein HPE50_RS19970 ENOG4105C9B Cysteine desulfurase HPE50_RS19975 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HPE50_RS19980 ENOG4105CUZ uba thif-type nad fad binding protein HPE50_RS19985 ENOG4105CA3 membrane-bound lytic murein transglycosylase HPE50_RS20010 ENOG4105C2X Arabinose 5-phosphate isomerase HPE50_RS20015 ENOG4105C87 Aminotransferase class I and II HPE50_RS20020 ENOG4105CI1 PTS System HPE50_RS20030 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPE50_RS20035 ENOG4108EKC n-acetylglutamate synthase HPE50_RS20040 ENOG4107QYX exodeoxyribonuclease v alpha HPE50_RS20045 ENOG4107QKA exodeoxyribonuclease V beta HPE50_RS20050 ENOG4107QXK peptidase HPE50_RS20055 ENOG4105DSY exodeoxyribonuclease V, gamma HPE50_RS20060 ENOG4105RVB Prepilin peptidase dependent protein c HPE50_RS20065 ENOG4105SEN Protein of unknown function (DUF2509) HPE50_RS20070 ENOG4105JCS prepilin peptidase dependent protein HPE50_RS20075 ENOG4105IPU prepilin peptidase dependent protein A HPE50_RS20105 ENOG4105EE5 Membrane protein terC HPE50_RS20110 ENOG4105SUV lipoprotein YgdR HPE50_RS20115 ENOG4105CPC Aldo Keto reductase HPE50_RS20130 ENOG41060NJ transcriptional regulator HPE50_RS20140 ENOG4105RQF LysR family Transcriptional regulator HPE50_RS20150 ENOG4107QNK )-transporter HPE50_RS20155 ENOG4105CHR reductase HPE50_RS20165 ENOG4105CHU acetyl-coa acetyltransferase HPE50_RS20170 ENOG4108MHD transport protein HPE50_RS20175 ENOG4105ISV protein with bipartite regulator domain HPE50_RS20180 ENOG4108TC1 Transcriptional regulator HPE50_RS20185 ENOG4105FV3 HPE50_RS20210 ENOG4108YAB Invasion protein HPE50_RS20220 ENOG4105K5T PilT protein HPE50_RS20240 ENOG4108RBT type iii secretion HPE50_RS20245 ENOG4106BTR HPE50_RS20250 ENOG4105Y7Q type iii secretion HPE50_RS20260 ENOG4108JUB Transcriptional regulator HPE50_RS20265 ENOG4108UTP (2Fe-2S)-binding domain protein HPE50_RS20270 ENOG4108HR6 Dehydrogenase HPE50_RS20275 ENOG4105C7W Xanthine dehydrogenase HPE50_RS20280 ENOG4108K5P (LipO)protein HPE50_RS20320 ENOG4105CRK lysyL-tRNA synthetase HPE50_RS20330 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPE50_RS20335 ENOG4105T95 Thiol disulfide interChange protein HPE50_RS20340 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPE50_RS20345 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HPE50_RS20350 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HPE50_RS20355 ENOG4105Y75 tpr repeat protein HPE50_RS20365 ENOG4108UT2 hemolysin iii HPE50_RS20375 ENOG4105CS2 ec 3.2.1.21 HPE50_RS20400 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPE50_RS20405 ENOG4105D0A hydroxylase HPE50_RS20410 ENOG4107RAQ aminopeptidase HPE50_RS20430 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPE50_RS20440 ENOG4108JQ1 Dehydrogenase HPE50_RS20455 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HPE50_RS20460 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HPE50_RS20465 ENOG4105E3J oxidoreductase HPE50_RS20475 ENOG4105D5P Methylmalonyl-coA mutase HPE50_RS20480 ENOG4105DJT lAO AO transport system ATPase HPE50_RS20485 ENOG4108M7F enoyl-CoA hydratase isomerase HPE50_RS20490 ENOG4105CYC Transferase HPE50_RS20500 ENOG4105MPN Membrane HPE50_RS20520 ENOG4105D64 Mechanosensitive ion channel HPE50_RS20525 ENOG4105D2N Aldolase HPE50_RS20555 ENOG4108JJB ABC transporter HPE50_RS20560 ENOG4108JJB ABC transporter HPE50_RS20565 ENOG4107Z1W Fructose transport system kinase HPE50_RS20570 ENOG4108R4K DNA-binding, transcriptional regulator HPE50_RS20575 ENOG4108Q8A Fructose-1,6-bisphosphatase HPE50_RS20580 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HPE50_RS20585 ENOG4105CTS PTS system mannitol-specific HPE50_RS20600 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HPE50_RS20605 ENOG4105EPW hflc protein HPE50_RS20610 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPE50_RS20615 ENOG4108K0D peptidase, M48 HPE50_RS20630 ENOG4105F3R pts system mannose fructose sorbose family iid HPE50_RS20635 ENOG4105ETZ PTS System HPE50_RS20640 ENOG4105DAS pts system HPE50_RS20665 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HPE50_RS20690 ENOG4107QNK )-transporter HPE50_RS20700 ENOG4105RWS endonuclease I HPE50_RS20705 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPE50_RS20710 ENOG4105D7Z glutathione synthase HPE50_RS20725 ENOG4105CZX twitching motility protein HPE50_RS20730 ENOG4105DFA alanine racemase domain protein HPE50_RS20735 ENOG4108VIA integral membrane protein HPE50_RS20745 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPE50_RS20750 ENOG4105CSA Coproporphyrinogen iii oxidase HPE50_RS20755 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPE50_RS20760 ENOG41069H7 transport system small permease component HPE50_RS20765 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPE50_RS20770 ENOG4106MH3 alpha helix chain HPE50_RS20775 ENOG4105HDK L-asparaginase HPE50_RS20780 ENOG4105K33 Periplasmic Protein HPE50_RS20785 ENOG41090ED Protein with unknown function (DUF469) HPE50_RS20795 ENOG4105CEN a g-specific adenine glycosylase HPE50_RS20810 ENOG4105EAA nucleoside HPE50_RS20815 ENOG4105CXN decarboxylase HPE50_RS20820 ENOG4108UQV Membrane HPE50_RS20850 ENOG4108YXQ IS66 Orf2 family protein HPE50_RS20855 ENOG4105E5H Transposase HPE50_RS20905 ENOG41067TZ transcriptional regulator, MarR family HPE50_RS20940 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR HPE50_RS20950 ENOG4106P2F Pfam:Pili_assembly_C HPE50_RS20960 ENOG4108ZJG MrfB protein HPE50_RS20985 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HPE50_RS21020 ENOG4105D05 Receptor HPE50_RS21075 ENOG4105I1J Autotransporter HPE50_RS21090 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HPE50_RS21095 ENOG4105DUU IucA IucC family protein HPE50_RS21140 ENOG4105E5H Transposase HPE50_RS21145 ENOG4108YXQ IS66 Orf2 family protein HPE50_RS21205 ENOG4105F4K antigen 43 HPE50_RS21210 ENOG4108PZQ Inner membrane protein YeeR HPE50_RS21225 ENOG4106H6R UPF0380 protein HPE50_RS21235 ENOG4105MFG Antirestriction protein HPE50_RS21240 ENOG4108YGG dna repair protein HPE50_RS21260 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HPE50_RS21300 ENOG4105C2X Arabinose 5-phosphate isomerase HPE50_RS21305 ENOG4105ECX polysaccharide export HPE50_RS21310 ENOG4107V1M polysaccharide export protein HPE50_RS21315 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HPE50_RS21320 ENOG4105E12 capsule polysaccharide HPE50_RS21325 ENOG41084CK capsule polysaccharide HPE50_RS21350 ENOG4105D2T synthase HPE50_RS21365 ENOG41090SZ ABC-2 type transporter HPE50_RS21370 ENOG4105U1E general secretion pathway protein M HPE50_RS21390 ENOG4105X5Z General secretion pathway protein I HPE50_RS21400 ENOG4108VAU general secretion pathway protein G HPE50_RS21405 ENOG4105D7Q type ii secretion system HPE50_RS21410 ENOG4107QHF type ii secretion system protein e HPE50_RS21425 ENOG410765S (LipO)protein HPE50_RS21430 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HPE50_RS21435 ENOG4105F88 accessory colonization factor AcfD HPE50_RS21440 ENOG4105DAA L-lactate HPE50_RS21445 ENOG4107QP3 malate synthase g HPE50_RS21450 ENOG4108ZJF Glcg protein HPE50_RS21455 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPE50_RS21460 ENOG4105EU8 FAD linked oxidase domain protein HPE50_RS21465 ENOG4105CQB FAD linked oxidase domain protein HPE50_RS21470 ENOG4108KWP DNA-binding transcriptional regulator GlcC HPE50_RS21485 ENOG4108GH0 ATP-binding protein yghT HPE50_RS21490 ENOG4105CJ3 phosphate transporter HPE50_RS21495 ENOG4106032 Glutathionylspermidine synthase HPE50_RS21500 ENOG4105CYM Glutathione S-transferase HPE50_RS21505 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HPE50_RS21510 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HPE50_RS21515 ENOG4108WGS hydrogenase 2-specific chaperone HPE50_RS21520 ENOG4108USZ hydrogenase HPE50_RS21525 ENOG4105DPX Hydrogenase, large subunit HPE50_RS21530 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HPE50_RS21535 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPE50_RS21540 ENOG4105E3S small subunit HPE50_RS21545 ENOG410900S Protein of unknown function (DUF2623) HPE50_RS21555 ENOG4105CPC Aldo Keto reductase HPE50_RS21565 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPE50_RS21570 ENOG4108ZZF transport protein (ExbD) HPE50_RS21575 ENOG4105CWK Biopolymer transport protein, ExbB HPE50_RS21580 ENOG4105C28 cystathionine HPE50_RS21585 ENOG4108K81 inner membrane protein YghB HPE50_RS21590 ENOG4105CF7 AraC family transcriptional regulator HPE50_RS21595 ENOG4108I6A alcohol dehydrogenase HPE50_RS21600 ENOG4105CV8 reductase HPE50_RS21605 ENOG4105ZKC Conserved Protein HPE50_RS21615 ENOG4105CCT upf0313 protein HPE50_RS21620 ENOG4107YCY Transcriptional regulator HPE50_RS21625 ENOG4105DEI Mannitol dehydrogenase HPE50_RS21630 ENOG4105CPQ Dehydrogenase HPE50_RS21635 ENOG4105DG4 malate L-lactate dehydrogenase HPE50_RS21640 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPE50_RS21650 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPE50_RS21655 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HPE50_RS21660 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HPE50_RS21675 ENOG4108J59 Extracellular solute-binding protein, family 5 HPE50_RS21680 ENOG4105F4I Transcriptional regulator HPE50_RS21685 ENOG4105H4F exported protein HPE50_RS21690 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPE50_RS21695 ENOG4105DHQ Histidine kinase HPE50_RS21700 ENOG4105NF4 modulator of drug activity HPE50_RS21705 ENOG4105VRH Antibiotic biosynthesis monooxygenase HPE50_RS21710 ENOG4106KNT transcriptional regulator HPE50_RS21720 ENOG4105EHG Permease protein HPE50_RS21725 ENOG4105DQ5 transport system permease protein HPE50_RS21730 ENOG4105E0A ABC, transporter HPE50_RS21740 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPE50_RS21745 ENOG4105IPS esterase HPE50_RS21750 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPE50_RS21755 ENOG4108SX3 cytoplasmic protein HPE50_RS21760 ENOG41087AY ADP-Ribose pyrophosphatase HPE50_RS21765 ENOG4105DFG type I secretion outer membrane protein HPE50_RS21775 ENOG4106032 Glutathionylspermidine synthase HPE50_RS21780 ENOG4108MR7 Arylsulfotransferase HPE50_RS21785 ENOG4108N92 Thiol disulfide Interchange Protein HPE50_RS21795 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HPE50_RS21810 ENOG4105W0Z cytoplasmic protein HPE50_RS21820 ENOG4105PV3 Inner membrane protein yqiJ HPE50_RS21825 ENOG4107S78 Band 7 protein HPE50_RS21845 ENOG4105I7R Adenylate cyclase HPE50_RS21850 ENOG4106MWK domain protein HPE50_RS21865 ENOG4107ZVW dihydroneopterin aldolase HPE50_RS21875 ENOG4105EJC lysr family transcriptional regulator HPE50_RS21880 ENOG4106DSS Tartrate dehydratase subunit alpha HPE50_RS21885 ENOG4107GFK fumarate HPE50_RS21890 ENOG4107QPK )-transporter HPE50_RS21905 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPE50_RS21910 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPE50_RS21930 ENOG4105Q26 Siderophore-interacting protein HPE50_RS21935 ENOG4105NTW Transcriptional regulator HPE50_RS21940 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HPE50_RS21950 ENOG4108Y51 tRNA-binding protein HPE50_RS21955 ENOG4105CQ4 Transcriptional regulator HPE50_RS21960 ENOG4105CNT hydrolase family 2 HPE50_RS21965 ENOG4105FK9 beta-D-galactosidase beta subunit HPE50_RS21970 ENOG4105E5D amino acid HPE50_RS21985 ENOG4107W6W Conserved Protein HPE50_RS21990 ENOG4107WCA isomerase HPE50_RS21995 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPE50_RS22000 ENOG4108Z3N Transcriptional regulator HPE50_RS22015 ENOG4108VKG metal-dependent hydrolase HPE50_RS22020 ENOG4108UB4 uncharacterized protein ygjQ HPE50_RS22025 ENOG4105EE0 oxidoreductase HPE50_RS22030 ENOG4105DU1 integral membrane protein, terc HPE50_RS22035 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HPE50_RS22040 ENOG4105P66 Membrane HPE50_RS22045 ENOG4105CTX dehydratase HPE50_RS22055 ENOG4105DPW Major facilitator superfamily MFS_1 HPE50_RS22080 ENOG4107YCY Transcriptional regulator HPE50_RS22085 ENOG4106W5V Membrane HPE50_RS22090 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HPE50_RS22095 ENOG4105WAY exported protein HPE50_RS22100 ENOG4105NE1 Conserved Protein HPE50_RS22105 ENOG41090KG Inner membrane protein YqjE HPE50_RS22110 ENOG4105YJD HPE50_RS22115 ENOG4108VBZ doxx family HPE50_RS22120 ENOG4105CHF Glutathione S-transferase HPE50_RS22125 ENOG4105KAF membrAne HPE50_RS22130 ENOG4105KAF membrAne HPE50_RS22135 ENOG4105CWB LysR family transcriptional Regulator HPE50_RS22140 ENOG4108CNN domain protein HPE50_RS22145 ENOG4106D80 Uncharacterized protein YhaL HPE50_RS22155 ENOG4105C44 Serine transporter HPE50_RS22160 ENOG4105EJQ L-serine dehydratase HPE50_RS22165 ENOG4105KME endoribonuclease L-psp HPE50_RS22170 ENOG4105C6N Formate acetyltransferase HPE50_RS22175 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPE50_RS22185 ENOG4105C7B Threonine dehydratase HPE50_RS22190 ENOG410811B TRANSCRIPTIONal HPE50_RS22215 ENOG4105BZW Glycerate kinase HPE50_RS22220 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPE50_RS22230 ENOG4105DJB Major Facilitator Superfamily HPE50_RS22245 ENOG4105ZEG Suppressor protein HPE50_RS22250 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HPE50_RS22255 ENOG4105E98 transcriptional regulator DeoR family HPE50_RS22265 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HPE50_RS22275 ENOG4105F3R pts system mannose fructose sorbose family iid HPE50_RS22280 ENOG4108YTN IIa component HPE50_RS22285 ENOG4105CE4 GlcNAc 6-P deacetylase HPE50_RS22290 ENOG4105E70 isomerase HPE50_RS22310 ENOG4105ETZ PTS System HPE50_RS22315 ENOG4105F3R pts system mannose fructose sorbose family iid HPE50_RS22320 ENOG4106HBN Galactosamine-6-phosphate isomerase HPE50_RS22325 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPE50_RS22345 ENOG4105W4M Transport-associated protein HPE50_RS22350 ENOG4107S21 permease HPE50_RS22355 ENOG4105K4T epimerase HPE50_RS22360 ENOG4107R7Y intracellular protease Pfpi family HPE50_RS22375 ENOG4108YYD acetyltransferase HPE50_RS22395 ENOG4105DEN Luciferase family HPE50_RS22400 ENOG4105CIC tryptophan-specific transport protein HPE50_RS22405 ENOG4105C1J atp-dependent rna helicase HPE50_RS22445 ENOG4105CHV Transcription elongation factor NusA HPE50_RS22465 ENOG4105DIJ Phosphoethanolamine transferase HPE50_RS22475 ENOG4105NTZ Preprotein translocase subunit SecG HPE50_RS22485 ENOG4105EEI dihydropteroate synthase HPE50_RS22490 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPE50_RS22500 ENOG4105HBR Rna-binding protein HPE50_RS22505 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HPE50_RS22510 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HPE50_RS22520 ENOG4105QYV Membrane HPE50_RS22535 ENOG4105EAH synthase HPE50_RS22540 ENOG4105HVQ Regulatory factor of maltose metabolism HPE50_RS22550 ENOG4105VFK BolA family HPE50_RS22555 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HPE50_RS22560 ENOG4105E3I toluene tolerance HPE50_RS22565 ENOG4107PE3 Mammalian cell entry related domain protein HPE50_RS22570 ENOG4105CY3 ABC transporter, permease HPE50_RS22575 ENOG4105DHJ ABC, transporter HPE50_RS22580 ENOG4105FEU K -dependent Na -Ca exchanger HPE50_RS22585 ENOG4105C2X Arabinose 5-phosphate isomerase HPE50_RS22595 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HPE50_RS22600 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HPE50_RS22605 ENOG4108IUZ ABC transporter HPE50_RS22610 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPE50_RS22615 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HPE50_RS22620 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HPE50_RS22630 ENOG41080Z8 PHOSPHOCARRIER protein HPE50_RS22635 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HPE50_RS22645 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HPE50_RS22650 ENOG4105BZU Histidine kinase HPE50_RS22655 ENOG4105N5T Radical SAM Protein HPE50_RS22660 ENOG4105CBC glutamate synthase HPE50_RS22665 ENOG4105BZ8 glutamate synthase HPE50_RS22675 ENOG4108R66 Conserved Protein HPE50_RS22720 ENOG4105KB2 stringent starvation protein b HPE50_RS22725 ENOG4107MKT Stringent starvation protein a HPE50_RS22740 ENOG4105D6Z AFG1 family ATPase HPE50_RS22745 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HPE50_RS22750 ENOG4105C0H protease HPE50_RS22755 ENOG4105C0H protease HPE50_RS22770 ENOG4105RID UPF0379 protein yhcN HPE50_RS22775 ENOG4105UNR (Barnase) inhibitor HPE50_RS22790 ENOG4105ZQC membrane protein AaeX HPE50_RS22795 ENOG4105CR8 Transcriptional regulator HPE50_RS22800 ENOG4105D1U peptidase U62 modulator of DNA gyrase HPE50_RS22805 ENOG4105QD6 exported protein HPE50_RS22810 ENOG4105C03 ribonuclease HPE50_RS22820 ENOG4105VQ7 Rod shape-determining protein MreD HPE50_RS22825 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HPE50_RS22835 ENOG41062P1 Diguanylate cyclase phosphodiesterase HPE50_RS22840 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HPE50_RS22850 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HPE50_RS22855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPE50_RS22865 ENOG4107UEK pfkb domain protein HPE50_RS22870 ENOG4105CNN ABC, transporter HPE50_RS22875 ENOG4105C2J ABC transporter HPE50_RS22880 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPE50_RS22885 ENOG4105D2N Aldolase HPE50_RS22890 ENOG4105E98 transcriptional regulator DeoR family HPE50_RS22895 ENOG4107UEK pfkb domain protein HPE50_RS22900 ENOG4105RG0 Membrane HPE50_RS22905 ENOG4108IA2 Sodium pantothenate symporter HPE50_RS22915 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPE50_RS22925 ENOG4105CEC DNA methylase N-4 N-6 HPE50_RS22930 ENOG41061ME transport protein HPE50_RS22935 ENOG4108XG4 DNA-binding transcriptional regulator HPE50_RS22940 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPE50_RS22955 ENOG4105XCM membrane LIPOPROTEIN HPE50_RS22965 ENOG4105EZ7 amino acid ABC transporter HPE50_RS22970 ENOG4105DRP amino acid AbC transporter HPE50_RS22975 ENOG4105CDA abc transporter atp-binding protein HPE50_RS23015 ENOG4108Z0R Transferase HPE50_RS23020 ENOG4105SG3 Protein of unknown function (DUF1488) HPE50_RS23035 ENOG4108WI1 Dna topoisomerase HPE50_RS23045 ENOG4105C79 DNA protecting protein DprA HPE50_RS23065 ENOG4105C1A potassium transporter peripheral membrane HPE50_RS23075 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HPE50_RS23080 ENOG4105W1Y Transcriptional regulator HPE50_RS23085 ENOG4105VTS DnaJ-like, subfamily C HPE50_RS23115 ENOG41067V7 50S ribosomal protein L36 HPE50_RS23120 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPE50_RS23165 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HPE50_RS23210 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HPE50_RS23235 ENOG4108UQY Iron-storage protein HPE50_RS23240 ENOG4105W53 bacterioferritin-associated ferredoxin HPE50_RS23270 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HPE50_RS23280 ENOG4105WWK YheO domain protein HPE50_RS23285 ENOG4108V1T peptidylprolyl cis-trans isomerase HPE50_RS23295 ENOG4108YZY peptidylprolyl cis-trans isomerase HPE50_RS23300 ENOG4105VKU nucleicacid-binding protein HPE50_RS23315 ENOG4105C5H ABC transporter HPE50_RS23320 ENOG4105DNZ Alpha Beta Hydrolase HPE50_RS23330 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HPE50_RS23335 ENOG4108UKZ OsmC family HPE50_RS23345 ENOG410613R integral membrane protein, YccS YhfK family HPE50_RS23350 ENOG4105C8Y Acetylornithine aminotransferase HPE50_RS23355 ENOG4105DDQ anthranilate synthase HPE50_RS23360 ENOG4105MZU cell filamentation protein HPE50_RS23370 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HPE50_RS23380 ENOG4107QZF nitrite reductase NADPH large subunit HPE50_RS23385 ENOG4105WZK nitrite reductase NADPH small subunit HPE50_RS23390 ENOG4107V9H nitrite transporter HPE50_RS23400 ENOG4105VYH HPE50_RS23405 ENOG4106PKC pyridoxal phosphate binding HPE50_RS23410 ENOG4106M0N transport system permease protein HPE50_RS23415 ENOG4105MUZ Protein of unknown function DUF2620 HPE50_RS23420 ENOG41080QX K07048 phosphotriesterase-related protein HPE50_RS23425 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HPE50_RS23430 ENOG4108626 Racemase HPE50_RS23435 ENOG4105RMW regulation of transcription, DNA-dependent HPE50_RS23440 ENOG4108M21 HPE50_RS23445 ENOG4105C31 Tryptophanyl-tRNA synthetase HPE50_RS23450 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPE50_RS23455 ENOG4105DJV ribulose-phosphate 3-epimerase HPE50_RS23460 ENOG4105DFE Dna adenine methylase HPE50_RS23465 ENOG4105EGB membrane protein DamX HPE50_RS23480 ENOG4105E4G Type IV pilus HPE50_RS23485 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HPE50_RS23490 ENOG4105XPX DNA utilization protein HofO HPE50_RS23495 ENOG41065NF Fimbrial assembly family protein HPE50_RS23500 ENOG4108U1Q Pilus assembly protein HPE50_RS23505 ENOG4108JQC penicillin-binding protein 1A HPE50_RS23510 ENOG4107RK2 ADP-ribose diphosphatase NudE HPE50_RS23515 ENOG4105DQY intracellular growth attenuator HPE50_RS23520 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HPE50_RS23525 ENOG4105VEJ Heat shock protein HPE50_RS23535 ENOG4108MAJ Membrane HPE50_RS23555 ENOG4105E0F Histidine kinase HPE50_RS23565 ENOG4108RRZ Transcription elongation factor GreB HPE50_RS23570 ENOG4105BZM domain protein HPE50_RS23575 ENOG4105XFK Ferrous iron transport protein A HPE50_RS23580 ENOG4105CE1 Ferrous iron transport protein b HPE50_RS23590 ENOG4105DNE Transposase HPE50_RS23610 ENOG4105C6Z Gluconate HPE50_RS23615 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HPE50_RS23620 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HPE50_RS23635 ENOG4105E0Y RtcB Protein HPE50_RS23640 ENOG4105CYB regulatoR HPE50_RS23645 ENOG4105E98 transcriptional regulator DeoR family HPE50_RS23660 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HPE50_RS23680 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HPE50_RS23700 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPE50_RS23705 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPE50_RS23710 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HPE50_RS23720 ENOG4105C9U ATP-dependent DNA helicase RecQ HPE50_RS23725 ENOG4105C6Z Gluconate HPE50_RS23730 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HPE50_RS23735 ENOG4105DIQ Transcriptional regulator HPE50_RS23740 ENOG4105C2I pirin domain protein HPE50_RS23745 ENOG4105D9R oxidoreductase HPE50_RS23750 ENOG4105WCN acetyltransferase HPE50_RS23755 ENOG4105GMB type VI secretion system effector, hcp1 family HPE50_RS23770 ENOG4106FA4 HPE50_RS23775 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPE50_RS23780 ENOG4105WC8 Conserved Protein HPE50_RS23785 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HPE50_RS23800 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HPE50_RS23805 ENOG4105BZ7 extracellular solute-binding protein family 1 HPE50_RS23815 ENOG4108IV0 ABC, transporter HPE50_RS23820 ENOG4105C0Z ABC transporter HPE50_RS23825 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPE50_RS23830 ENOG4105C32 Amino acid ABC transporter (Permease) HPE50_RS23835 ENOG4105CP9 extracellular ligand-binding receptor HPE50_RS23840 ENOG4105U59 -acetyltransferase HPE50_RS23845 ENOG4105CP9 extracellular ligand-binding receptor HPE50_RS23850 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPE50_RS23855 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPE50_RS23860 ENOG4105CAK Cell division ATP-binding protein ftsE HPE50_RS23865 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPE50_RS23870 ENOG4106H78 methyltransferase HPE50_RS23875 ENOG4105MG3 Membrane HPE50_RS23885 ENOG4107FS9 Membrane HPE50_RS23900 ENOG4105EX9 Membrane HPE50_RS23905 ENOG4108W1V Lipoprotein HPE50_RS23910 ENOG4105F9N Major Facilitator Superfamily HPE50_RS23915 ENOG4105DSF transport protein HPE50_RS23920 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HPE50_RS23925 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HPE50_RS23930 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPE50_RS23935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPE50_RS23940 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HPE50_RS23965 ENOG41090UW PTS System HPE50_RS23970 ENOG4105DT3 PTS system, galactitol-specific IIc component HPE50_RS23985 ENOG4105D2N Aldolase HPE50_RS24000 ENOG4105CMI transporter HPE50_RS24005 ENOG4105CJ1 ABC, transporter HPE50_RS24010 ENOG4105D0S secretion protein (HlyD HPE50_RS24025 ENOG4107UNS conserved inner membrane protein HPE50_RS24030 ENOG4105CBX hi0933 family HPE50_RS24035 ENOG4105CJ3 phosphate transporter HPE50_RS24050 ENOG4105DUX Transporter HPE50_RS24055 ENOG4105CHR reductase HPE50_RS24060 ENOG4105CTS PTS system mannitol-specific HPE50_RS24070 ENOG4107EDW L-fucose operon activator HPE50_RS24075 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HPE50_RS24080 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HPE50_RS24085 ENOG4105DCT glycerol dehydrogenase HPE50_RS24090 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HPE50_RS24095 ENOG41080HJ 6-phospho 3-hexuloisomerase HPE50_RS24100 ENOG4105DJV ribulose-phosphate 3-epimerase HPE50_RS24110 ENOG4105DGW oligopeptidase A HPE50_RS24115 ENOG4105D6S protein involved in catabolism of external DNA HPE50_RS24120 ENOG4105DC8 reductase HPE50_RS24130 ENOG4105KBH arsR family transcriptional regulator HPE50_RS24135 ENOG4107R5R arsenical pump membrane protein HPE50_RS24140 ENOG4105K89 arsenate reductase HPE50_RS24170 ENOG4105Y4Z Outer Membrane Lipoprotein HPE50_RS24180 ENOG4106QJH hemin transport protein HPE50_RS24185 ENOG4107ENK receptor HPE50_RS24195 ENOG4105D4P Coproporphyrinogen iii oxidase HPE50_RS24200 ENOG41090JE Utilization Protein HPE50_RS24210 ENOG4105EHG Permease protein HPE50_RS24215 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HPE50_RS24220 ENOG4105KT7 mgtC SapB transporter HPE50_RS24225 ENOG4105XXV Acid-resistance protein HPE50_RS24230 ENOG41060V2 Acid-resistance protein HPE50_RS24235 ENOG4108YK4 Acid-resistance membrane protein HPE50_RS24240 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HPE50_RS24250 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPE50_RS24255 ENOG4105BZS acriflavin resistance protein HPE50_RS24270 ENOG4105CVK Glutamate decarboxylase HPE50_RS24275 ENOG4105CA0 peroxidase HPE50_RS24285 ENOG4106S2D Transcriptional regulator HPE50_RS24295 ENOG4105CBN LysR family transcriptional regulator HPE50_RS24300 ENOG4107H3J ribonuclease HPE50_RS24305 ENOG4105CSH Transporter HPE50_RS24310 ENOG41066T0 asmA family HPE50_RS24315 ENOG4105CMB EAL domain-containing protein HPE50_RS24320 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HPE50_RS24325 ENOG4105CS0 peptidase HPE50_RS24335 ENOG4105BZU Histidine kinase HPE50_RS24340 ENOG4105EJG cellulose synthase HPE50_RS24345 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HPE50_RS24350 ENOG4107EEX Cellulose synthase regulator protein HPE50_RS24355 ENOG4107QZ7 Cellulose synthase catalytic subunit HPE50_RS24380 ENOG4105WQA Cellulose biosynthesis protein BcsF HPE50_RS24385 ENOG4105D1V cellulose synthase operon protein YhjU HPE50_RS24415 ENOG4105C44 Serine transporter HPE50_RS24420 ENOG4108JQ7 (ABC) transporter HPE50_RS24425 ENOG4105C3U ABC transporter HPE50_RS24430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPE50_RS24435 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPE50_RS24440 ENOG4105DEF Extracellular solute-binding protein, family 5 HPE50_RS24450 ENOG4105DIJ Phosphoethanolamine transferase HPE50_RS24455 ENOG4105FCD Major Facilitator HPE50_RS24460 ENOG4105EAX Putative lipase HPE50_RS24465 ENOG4108R3E Dna-3-methyladenine glycosylase i HPE50_RS24470 ENOG4105HNP -acetyltransferase HPE50_RS24480 ENOG4108ZG0 Ompa motb domain protein HPE50_RS24490 ENOG4106JH6 (LipO)protein HPE50_RS24495 ENOG4105MVF Transcriptional regulator HPE50_RS24505 ENOG41060TC Hok gef cell toxic protein HPE50_RS24530 ENOG4105MEV Acyl-transferase HPE50_RS24535 ENOG4108Z12 YiaAB two helix domain-containing protein HPE50_RS24540 ENOG410688U Inner membrane protein yiaB HPE50_RS24565 ENOG4108HWW ABC transporter HPE50_RS24570 ENOG4105T16 Transcriptional regulator (AraC family) HPE50_RS24575 ENOG4108UR8 BAX protein HPE50_RS24580 ENOG4107T9C Alpha amylase catalytic region HPE50_RS24585 ENOG4105JKW Valine--pyruvate aminotransferase HPE50_RS24590 ENOG4108XIB electron transport protein ysaA HPE50_RS24595 ENOG4105J4Q Transcriptional regulator HPE50_RS24605 ENOG4108R66 Conserved Protein HPE50_RS24610 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HPE50_RS24615 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPE50_RS24620 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPE50_RS24625 ENOG4105CMG Carbohydrate kinase HPE50_RS24630 ENOG4105H6Q decarboxylase HPE50_RS24635 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HPE50_RS24640 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPE50_RS24650 ENOG4105CT4 transporter HPE50_RS24660 ENOG4105GNX MltA-interacting MipA family protein HPE50_RS24665 ENOG4108Q2M Transcriptional regulator HPE50_RS24670 ENOG4105EFX secretion protein, HlyD family HPE50_RS24675 ENOG4105KK7 inner membrane protein YiaW HPE50_RS24685 ENOG4105C26 Dehydrogenase HPE50_RS24695 ENOG4105C0A alcohol dehydrogenase HPE50_RS24700 ENOG4105EM7 Selenocysteine-specific translation elongation factor HPE50_RS24710 ENOG4108U78 Glutathione S-transferase HPE50_RS24715 ENOG4105EFX secretion protein, HlyD family HPE50_RS24720 ENOG4105FP6 Protein of unknown function (DUF3302) HPE50_RS24725 ENOG4105CTS PTS system mannitol-specific HPE50_RS24735 ENOG4105E61 Mannitol repressor protein HPE50_RS24740 ENOG41060ND LF82 chromosome, complete sequence HPE50_RS24745 ENOG4108YYI Protein of unknown function (DUF2810) HPE50_RS24765 ENOG4105DAA L-lactate HPE50_RS24770 ENOG41073TP transcriptional regulator HPE50_RS24780 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HPE50_RS24785 ENOG4105D7W serine acetyltransferase HPE50_RS24800 ENOG4105VW4 glutaredoxin 3 HPE50_RS24805 ENOG4107YZP Rhodanese domain protein HPE50_RS24815 ENOG41063SB peptidase HPE50_RS24820 ENOG4105PXI polysaccharide deacetylase HPE50_RS24825 ENOG4105K64 Glycosyl transferase, family 2 HPE50_RS24835 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPE50_RS24845 ENOG4105XA0 heptosyltransferase ii HPE50_RS24850 ENOG4105D16 lipopolysaccharide heptosyltransferase i HPE50_RS24855 ENOG41068PG O-Antigen polymerase HPE50_RS24860 ENOG4105K64 Glycosyl transferase, family 2 HPE50_RS24865 ENOG4105X1N Glycosyl transferase family 8 HPE50_RS24875 ENOG4105X1N Glycosyl transferase family 8 HPE50_RS24880 ENOG4106AH0 Glycosyl Transferase HPE50_RS24885 ENOG4107543 (lipo)polysaccharide HPE50_RS24890 ENOG4107RJ7 Glycosyl transferase (Group 1 HPE50_RS24895 ENOG4105DKP glycosyl transferase, family 9 HPE50_RS24900 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HPE50_RS24920 ENOG4105KDC 50s ribosomal protein l28 HPE50_RS24930 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPE50_RS24935 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HPE50_RS24955 ENOG4105DSJ YicC domain protein HPE50_RS24965 ENOG4105EN6 Membrane HPE50_RS24975 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HPE50_RS24985 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPE50_RS24990 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HPE50_RS24995 ENOG4105CB5 ATP-dependent DNA helicase recG HPE50_RS25000 ENOG4105D6U Sodium Glutamate Symporter HPE50_RS25005 ENOG4105C2W permease HPE50_RS25010 ENOG4105JV1 AsmA family HPE50_RS25020 ENOG4105DKQ ROK family HPE50_RS25030 ENOG4105D2N Aldolase HPE50_RS25035 ENOG4105DM4 PTS System HPE50_RS25040 ENOG4108YRF PTS System HPE50_RS25045 ENOG4105DM4 PTS System HPE50_RS25050 ENOG4105ETD TRANSCRIPTIONal HPE50_RS25055 ENOG4105CJQ hydrolase, family 31 HPE50_RS25060 ENOG4105CT4 transporter HPE50_RS25075 ENOG4105S8Q sugar efflux transporter HPE50_RS25080 ENOG4108UZ3 Transporter HPE50_RS25085 ENOG4105D01 (LipO)protein HPE50_RS25090 ENOG4105T8A Uncharacterized protein YicS HPE50_RS25115 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HPE50_RS25135 ENOG4105TNG K13735 adhesin invasin HPE50_RS25155 ENOG4108SAJ Protein of unknown function (DUF1198) HPE50_RS25160 ENOG4105C7N Xanthine uracil vitamin C permease HPE50_RS25170 ENOG4105CXY transporter HPE50_RS25175 ENOG4105CXY transporter HPE50_RS25180 ENOG4105BZU Histidine kinase HPE50_RS25185 ENOG4108KX4 response regulator HPE50_RS25205 ENOG4105M71 acetolactate synthase 1 regulatory subunit HPE50_RS25210 ENOG4105C7K acetolactate synthase HPE50_RS25225 ENOG4105E5M Multidrug resistance protein D HPE50_RS25230 ENOG4105J13 transcriptional regulator HPE50_RS25235 ENOG4105JP4 Inner membrane protein yidG HPE50_RS25240 ENOG4105VG5 Membrane HPE50_RS25245 ENOG4106DRA Inner membrane protein YidI HPE50_RS25255 ENOG4107RUZ Sss sodium solute transporter superfamily HPE50_RS25260 ENOG4108AHD Transcriptional regulator HPE50_RS25265 ENOG4105F8D glycoside hydrolase family 4 HPE50_RS25270 ENOG4105CI1 PTS System HPE50_RS25280 ENOG4105VNT transposase (IS4 family) protein HPE50_RS25300 ENOG4108VVK transcriptional Regulator, AsnC HPE50_RS25305 ENOG4105QTB Flavodoxin HPE50_RS25320 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HPE50_RS25370 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HPE50_RS25375 ENOG4108RQP Major type 1 subunit fimbrin HPE50_RS25385 ENOG4105CW0 outer membrane usher protein HPE50_RS25395 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HPE50_RS25400 ENOG4105C8U phosphate abc transporter HPE50_RS25405 ENOG4105E2Z phosphate ABC transporter (Permease HPE50_RS25410 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HPE50_RS25415 ENOG4108UTW Plays a role in the regulation of phosphate uptake HPE50_RS25435 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HPE50_RS25440 ENOG4105C7N Xanthine uracil vitamin C permease HPE50_RS25445 ENOG4108YYH Nadph-dependent fmn reductase HPE50_RS25450 ENOG4105E8Q phosphopantetheinyl transferase HPE50_RS25455 ENOG4105G2Y Transcriptional regulator HPE50_RS25510 ENOG4105VG0 50S ribosomal protein l34 HPE50_RS25565 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HPE50_RS25605 ENOG41073YN Protein of unknown function (DUF1380) HPE50_RS25610 ENOG4106JQ7 HPE50_RS25755 ENOG4105KK6 nuclease HPE50_RS25785 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPE50_RS25875 ENOG4105CZX twitching motility protein HPE50_RS25910 ENOG4105K5T PilT protein HPE50_RS25925 ENOG4107QHF type ii secretion system protein e HPE50_RS25965 ENOG4107S78 Band 7 protein HPE50_RS25970 ENOG4105PV3 Inner membrane protein yqiJ HPE50_RS26020 ENOG4107ENK receptor HPE50_RS26050 ENOG4108YXQ IS66 Orf2 family protein HPE50_RS26100 ENOG41063SR receptor HPE50_RS26120 ENOG4105I1J Autotransporter HPE50_RS26125 ENOG4105F2I Transposase HPE50_RS26145 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPE50_RS26150 ENOG4107R39 (ABC) transporter HPE50_RS26155 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPE50_RS26170 ENOG4107SJW iron permease, FTR1 HPE50_RS26175 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HPE50_RS26180 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPE50_RS26230 ENOG4106CQM replication HPE50_RS26240 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HPE50_RS26255 ENOG4105KK6 nuclease HPE50_RS26265 ENOG4107CBI conjugal transfer fertility inhibition protein HPE50_RS26270 ENOG4107U2T alpha beta HPE50_RS26530 ENOG41073YN Protein of unknown function (DUF1380) HPE50_RS26535 ENOG4106JQ7 HPE50_RS26595 ENOG4105FEQ ParB domain protein nuclease HPE50_RS26615 ENOG41074AV Hok/gef family HPE50_RS26825 ENOG4107CBI conjugal transfer fertility inhibition protein HPE50_RS26835 ENOG4105KK6 nuclease HPE50_RS26885 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)