locus-tag	class	description
HPE50_RS00010	COG0592	DNA-directed DNA polymerase activity
HPE50_RS00020	COG0187	DNA topoisomerase II activity
HPE50_RS00025	COG3753	Protein conserved in bacteria
HPE50_RS00030	COG0561	phosphatase activity
HPE50_RS00040	COG2186	Transcriptional regulator
HPE50_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HPE50_RS00050	COG0800	Aldolase
HPE50_RS00070	COG2271	Major facilitator Superfamily
HPE50_RS00080	COG0823	Involved in the tonB-independent uptake of proteins
HPE50_RS00085	COG5645	(Lipo)protein
HPE50_RS00110	COG3385	transposase activity
HPE50_RS00125	COG1129	ABC transporter
HPE50_RS00130	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPE50_RS00135	COG1879	ABC-type sugar transport system periplasmic component
HPE50_RS00140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS00145	COG1609	Transcriptional regulator
HPE50_RS00150	COG0477	Major facilitator Superfamily
HPE50_RS00155	COG2186	Transcriptional regulator
HPE50_RS00195	COG3085	chromosome segregation
HPE50_RS00200	COG0606	chelatase, subunit chli
HPE50_RS00220	COG3978	acetolactate synthase activity
HPE50_RS00225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPE50_RS00235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPE50_RS00240	COG0583	DNA-binding transcription factor activity
HPE50_RS00250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPE50_RS00255	COG3692	DNA binding
HPE50_RS00260	COG0210	DNA helicase
HPE50_RS00275	COG3118	belongs to the thioredoxin family
HPE50_RS00285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPE50_RS00290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPE50_RS00295	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPE50_RS00300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPE50_RS00305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPE50_RS00310	COG1088	dTDP-glucose 4,6-dehydratase activity
HPE50_RS00315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPE50_RS00320	COG0456	acetyltransferase
HPE50_RS00325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPE50_RS00330	COG2244	polysaccharide biosynthetic process
HPE50_RS00350	COG1113	amino acid transport
HPE50_RS00375	COG0641	radical SAM
HPE50_RS00380	COG3119	arylsulfatase activity
HPE50_RS00390	COG3071	HemY protein
HPE50_RS00395	COG2959	enzyme of heme biosynthesis
HPE50_RS00400	COG1587	Uroporphyrinogen-III synthase
HPE50_RS00410	COG3072	Adenylate cyclase
HPE50_RS00425	COG5567	small periplasmic lipoprotein
HPE50_RS00435	COG3159	Protein conserved in bacteria
HPE50_RS00445	COG1011	Hydrolase
HPE50_RS00450	COG0210	DNA helicase
HPE50_RS00455	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HPE50_RS00460	COG3698	Phosphodiester glycosidase
HPE50_RS00465	COG3385	transposase activity
HPE50_RS00470	COG3698	Phosphodiester glycosidase
HPE50_RS00475	COG0598	Magnesium transport protein CorA
HPE50_RS00485	COG2962	Rard protein
HPE50_RS00490	COG2050	protein possibly involved in aromatic compounds catabolism
HPE50_RS00495	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HPE50_RS00500	COG0514	ATP-dependent DNA helicase (RecQ)
HPE50_RS00505	COG1280	lysine exporter protein (LysE YggA)
HPE50_RS00510	COG1280	lysine exporter protein (LysE YggA)
HPE50_RS00515	COG2267	carboxylic ester hydrolase activity
HPE50_RS00520	COG0561	phosphatase activity
HPE50_RS00525	COG0697	spore germination
HPE50_RS00530	COG0583	DNA-binding transcription factor activity
HPE50_RS00540	COG0583	DNA-binding transcription factor activity
HPE50_RS00545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPE50_RS00555	COG0549	Belongs to the carbamate kinase family
HPE50_RS00560	COG1304	FMN binding
HPE50_RS00565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPE50_RS00575	COG1335	isochorismatase
HPE50_RS00580	COG0412	Dienelactone hydrolase
HPE50_RS00585	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPE50_RS00605	COG0800	Aldolase
HPE50_RS00610	COG3734	2-keto-3-deoxy-galactonokinase
HPE50_RS00615	COG1414	Transcriptional regulator
HPE50_RS00620	COG1322	Protein conserved in bacteria
HPE50_RS00630	COG3165	ubiquinone biosynthetic process from chorismate
HPE50_RS00640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPE50_RS00645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPE50_RS00650	COG0805	protein transport
HPE50_RS00665	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPE50_RS00670	COG0543	2 iron, 2 sulfur cluster binding
HPE50_RS00690	COG1739	Uncharacterized protein family UPF0029
HPE50_RS00695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPE50_RS00700	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPE50_RS00730	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPE50_RS00735	COG0746	molybdenum cofactor guanylyltransferase activity
HPE50_RS00740	COG3084	Protein conserved in bacteria
HPE50_RS00745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPE50_RS00750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPE50_RS00755	COG5339	Protein conserved in bacteria
HPE50_RS00760	COG0204	Acyl-transferase
HPE50_RS00765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPE50_RS00765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPE50_RS00780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPE50_RS00790	COG2204	response regulator
HPE50_RS00795	COG3852	Histidine kinase
HPE50_RS00800	COG0174	glutamine synthetase
HPE50_RS00810	COG1349	DNA-binding transcription factor activity
HPE50_RS00815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS00820	COG2084	Dehydrogenase
HPE50_RS00825	COG3684	Belongs to the aldolase LacD family
HPE50_RS00830	COG1063	alcohol dehydrogenase
HPE50_RS00840	COG0477	Major facilitator Superfamily
HPE50_RS00850	COG1011	Hydrolase
HPE50_RS00865	COG0456	acetyltransferase
HPE50_RS00875	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPE50_RS00880	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPE50_RS00890	COG2864	formate dehydrogenase
HPE50_RS00895	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS00915	COG3711	transcriptional antiterminator
HPE50_RS00915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS00920	COG1363	Peptidase, m42
HPE50_RS00925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS00925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS00930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS00965	COG1917	Cupin 2, conserved barrel domain protein
HPE50_RS00965	COG4977	sequence-specific DNA binding
HPE50_RS00975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPE50_RS00985	COG2258	MOSC domain
HPE50_RS00990	COG2205	protein histidine kinase activity
HPE50_RS00995	COG0745	RESPONSE REGULATOR receiver
HPE50_RS01000	COG3678	ATP-independent chaperone mediated protein folding
HPE50_RS01015	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPE50_RS01035	COG3152	Membrane
HPE50_RS01040	COG3691	Protein conserved in bacteria
HPE50_RS01045	COG0589	response to stress
HPE50_RS01055	COG1494	fructose-1,6-bisphosphatase
HPE50_RS01065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPE50_RS01090	COG1575	Belongs to the MenA family. Type 1 subfamily
HPE50_RS01105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPE50_RS01110	COG1609	Transcriptional regulator
HPE50_RS01115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPE50_RS01125	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPE50_RS01135	COG0626	cystathionine gamma-synthase activity
HPE50_RS01140	COG0527	aspartate kinase activity
HPE50_RS01140	COG0460	homoserine dehydrogenase
HPE50_RS01150	COG0737	Belongs to the 5'-nucleotidase family
HPE50_RS01155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPE50_RS01165	COG0697	spore germination
HPE50_RS01170	COG3738	Protein conserved in bacteria
HPE50_RS01175	COG0371	Dehydrogenase
HPE50_RS01180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPE50_RS01185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS01185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS01185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPE50_RS01190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS01195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS01200	COG1882	Formate acetyltransferase
HPE50_RS01205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPE50_RS01210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS01215	COG2207	Transcriptional regulator
HPE50_RS01220	COG2194	sulfuric ester hydrolase activity
HPE50_RS01235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPE50_RS01250	COG4948	Mandelate Racemase Muconate Lactonizing
HPE50_RS01255	COG2271	Major facilitator Superfamily
HPE50_RS01260	COG0583	DNA-binding transcription factor activity
HPE50_RS01270	COG1309	transcriptional regulator
HPE50_RS01285	COG4206	TonB-dependent receptor
HPE50_RS01315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPE50_RS01320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HPE50_RS01320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HPE50_RS01355	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPE50_RS01360	COG0250	Participates in transcription elongation, termination and antitermination
HPE50_RS01395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPE50_RS01405	COG2104	thiamine diphosphate biosynthetic process
HPE50_RS01410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPE50_RS01445	COG3068	Protein conserved in bacteria
HPE50_RS01460	COG3678	ATP-independent chaperone mediated protein folding
HPE50_RS01465	COG4191	Histidine kinase
HPE50_RS01470	COG2204	response regulator
HPE50_RS01475	COG0151	Belongs to the GarS family
HPE50_RS01505	COG0456	acetyltransferase
HPE50_RS01515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPE50_RS01520	COG2224	Isocitrate lyase
HPE50_RS01530	COG1414	Transcriptional regulator
HPE50_RS01535	COG0646	methionine synthase
HPE50_RS01535	COG1410	methionine synthase
HPE50_RS01540	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPE50_RS01550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPE50_RS01590	COG1187	pseudouridine synthase activity
HPE50_RS01610	COG3385	transposase activity
HPE50_RS01625	COG0527	aspartate kinase activity
HPE50_RS01650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPE50_RS01665	COG3833	ABC-type maltose transport systems, permease component
HPE50_RS01670	COG1175	transmembrane transport
HPE50_RS01675	COG2182	Extracellular solute-binding protein
HPE50_RS01680	COG3842	ATPase activity
HPE50_RS01695	COG1357	PFAM Pentapeptide repeats (8 copies)
HPE50_RS01715	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPE50_RS01740	COG3237	CsbD-like
HPE50_RS01745	COG0735	belongs to the Fur family
HPE50_RS01755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPE50_RS01765	COG0604	alcohol dehydrogenase
HPE50_RS01770	COG0305	Participates in initiation and elongation during chromosome replication
HPE50_RS01775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPE50_RS01780	COG1448	Aminotransferase
HPE50_RS01790	COG3700	Belongs to the class B bacterial acid phosphatase family
HPE50_RS01795	COG0432	Pfam Uncharacterised protein family UPF0047
HPE50_RS01800	COG2315	Protein conserved in bacteria
HPE50_RS01805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPE50_RS01810	COG0629	single-stranded DNA binding
HPE50_RS01850	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HPE50_RS01855	COG2207	Transcriptional regulator
HPE50_RS01860	COG0789	Transcriptional regulator
HPE50_RS01865	COG2252	PERMEase
HPE50_RS01870	COG3385	transposase activity
HPE50_RS01875	COG0025	NhaP-type Na H and K H
HPE50_RS01885	COG3162	membrane
HPE50_RS01890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPE50_RS01900	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HPE50_RS01905	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS01910	COG3301	Polysulphide reductase, NrfD
HPE50_RS01915	COG1138	Cytochrome C-type biogenesis protein
HPE50_RS01920	COG3088	subunit of a heme lyase
HPE50_RS01925	COG4235	cytochrome complex assembly
HPE50_RS01930	COG1301	dicarboxylic acid transport
HPE50_RS01935	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPE50_RS01950	COG1289	transmembrane transporter activity
HPE50_RS01955	COG1566	PFAM secretion protein HlyD family protein
HPE50_RS01970	COG1940	carbohydrate kinase activity
HPE50_RS01975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPE50_RS01985	COG1129	ABC transporter
HPE50_RS01990	COG1879	ABC-type sugar transport system periplasmic component
HPE50_RS01995	COG1737	Transcriptional regulator
HPE50_RS02000	COG0698	ribose 5-phosphate isomerase
HPE50_RS02010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPE50_RS02015	COG0456	acetyltransferase
HPE50_RS02025	COG3454	Phosphonate metabolism
HPE50_RS02030	COG4778	phosphonate C-P lyase system protein PhnL
HPE50_RS02035	COG4107	phosphonate C-P lyase system protein PhnK
HPE50_RS02040	COG3627	carbon phosphorus lyase activity
HPE50_RS02045	COG3626	phosphonate metabolism
HPE50_RS02050	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HPE50_RS02055	COG3624	Phosphonate C-P lyase system protein PhnG
HPE50_RS02060	COG2188	Transcriptional regulator
HPE50_RS02065	COG3639	organic phosphonate transmembrane transporter activity
HPE50_RS02070	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HPE50_RS02080	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HPE50_RS02085	COG2824	Alkylphosphonate utilization operon protein PhnA
HPE50_RS02090	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPE50_RS02100	COG0477	Major facilitator Superfamily
HPE50_RS02110	COG0642	Histidine kinase
HPE50_RS02115	COG0745	RESPONSE REGULATOR receiver
HPE50_RS02120	COG2194	sulfuric ester hydrolase activity
HPE50_RS02125	COG0531	amino acid
HPE50_RS02130	COG2207	Transcriptional regulator
HPE50_RS02135	COG1982	Orn Lys Arg decarboxylase major
HPE50_RS02140	COG2169	Transcriptional regulator
HPE50_RS02145	COG1486	melibiose metabolic process
HPE50_RS02150	COG3647	Membrane
HPE50_RS02155	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HPE50_RS02155	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPE50_RS02160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPE50_RS02165	COG4565	transcriptional regulatory protein
HPE50_RS02170	COG3290	protein histidine kinase activity
HPE50_RS02175	COG3592	Divergent 4Fe-4S mono-cluster
HPE50_RS02180	COG2388	GCN5-related N-acetyl-transferase
HPE50_RS02195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPE50_RS02200	COG3104	oligopeptide transport
HPE50_RS02205	COG1982	Orn Lys Arg decarboxylase major
HPE50_RS02210	COG0531	amino acid
HPE50_RS02215	COG3710	Transcriptional regulator
HPE50_RS02225	COG1309	transcriptional regulator
HPE50_RS02240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPE50_RS02245	COG1027	Aspartate ammonia-lyase
HPE50_RS02250	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPE50_RS02255	COG0531	amino acid
HPE50_RS02280	COG1509	lysine 2,3-aminomutase activity
HPE50_RS02290	COG5510	response to toxic substance
HPE50_RS02295	COG5510	response to toxic substance
HPE50_RS02300	COG2076	Multidrug Resistance protein
HPE50_RS02305	COG3040	lipid binding
HPE50_RS02310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPE50_RS02325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPE50_RS02330	COG1053	succinate dehydrogenase
HPE50_RS02340	COG0531	amino acid
HPE50_RS02355	COG3264	Mechanosensitive ion channel
HPE50_RS02355	COG1511	domain protein
HPE50_RS02395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPE50_RS02400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPE50_RS02400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPE50_RS02405	COG0802	atpase or kinase
HPE50_RS02410	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPE50_RS02430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPE50_RS02435	COG0330	HflC and HflK could
HPE50_RS02440	COG0330	HflC and HflK could
HPE50_RS02445	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPE50_RS02460	COG0557	exoribonuclease II activity
HPE50_RS02465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPE50_RS02470	COG1414	Transcriptional regulator
HPE50_RS02475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPE50_RS02480	COG2271	Major facilitator Superfamily
HPE50_RS02485	COG2721	sulfolactate sulfo-lyase activity
HPE50_RS02495	COG1842	Phage shock protein A
HPE50_RS02505	COG3766	membrane
HPE50_RS02510	COG5463	Belongs to the UPF0441 family
HPE50_RS02515	COG0754	glutathionylspermidine amidase activity
HPE50_RS02520	COG1960	acyl-CoA dehydrogenase activity
HPE50_RS02530	COG3650	response to hydrogen peroxide
HPE50_RS02535	COG1073	alpha beta
HPE50_RS02550	COG3037	sugar-specific permease SgaT UlaA
HPE50_RS02555	COG3414	Phosphotransferase system galactitol-specific IIB component
HPE50_RS02560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS02575	COG0235	Class ii aldolase
HPE50_RS02580	COG3477	response to acidic pH
HPE50_RS02600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPE50_RS02625	COG0675	Transposase, IS605 OrfB family
HPE50_RS02635	COG3061	Opacity-associated protein A
HPE50_RS02640	COG0545	Peptidyl-prolyl cis-trans isomerase
HPE50_RS02645	COG1113	amino acid transport
HPE50_RS02655	COG0697	spore germination
HPE50_RS02665	COG1733	regulation of RNA biosynthetic process
HPE50_RS02670	COG0737	Belongs to the 5'-nucleotidase family
HPE50_RS02675	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPE50_RS02685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPE50_RS02695	COG1253	flavin adenine dinucleotide binding
HPE50_RS02705	COG0729	surface antigen
HPE50_RS02710	COG2911	Protein conserved in bacteria
HPE50_RS02715	COG2105	PFAM AIG2 family protein
HPE50_RS02720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPE50_RS02725	COG1879	ABC-type sugar transport system periplasmic component
HPE50_RS02730	COG1129	ABC transporter
HPE50_RS02735	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPE50_RS02740	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPE50_RS02750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPE50_RS02760	COG0312	modulator of DNA gyrase
HPE50_RS02765	COG3783	Cytochrome b(562)
HPE50_RS02770	COG0602	queuosine metabolic process
HPE50_RS02775	COG1328	CTP reductase activity
HPE50_RS02780	COG0366	Alpha amylase catalytic
HPE50_RS02785	COG1263	PTS System
HPE50_RS02785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS02790	COG1609	Transcriptional regulator
HPE50_RS02800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPE50_RS02805	COG0251	oxidation-reduction process
HPE50_RS02825	COG0251	oxidation-reduction process
HPE50_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS02835	COG1309	transcriptional regulator
HPE50_RS02840	COG2731	YhcH YjgK YiaL family protein
HPE50_RS02855	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HPE50_RS02860	COG0456	acetyltransferase
HPE50_RS02865	COG4269	membrane
HPE50_RS02870	COG0525	valine-tRNA ligase activity
HPE50_RS02875	COG2927	DNA polymerase III (CHI subunit)
HPE50_RS02885	COG0795	lipopolysaccharide-transporting ATPase activity
HPE50_RS02890	COG0795	lipopolysaccharide-transporting ATPase activity
HPE50_RS02895	COG0433	COG0433 Predicted ATPase
HPE50_RS02900	COG1064	alcohol dehydrogenase
HPE50_RS02985	COG3547	Transposase (IS116 IS110 IS902 family)
HPE50_RS03000	COG1309	transcriptional regulator
HPE50_RS03010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPE50_RS03025	COG2990	Protein conserved in bacteria
HPE50_RS03030	COG0297	glycogen (starch) synthase activity
HPE50_RS03035	COG0726	polysaccharide deacetylase
HPE50_RS03045	COG2085	NADP oxidoreductase coenzyme F420-dependent
HPE50_RS03050	COG1120	ATPase activity
HPE50_RS03055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPE50_RS03060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPE50_RS03065	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPE50_RS03070	COG4772	TonB-dependent receptor
HPE50_RS03075	COG3712	iron ion homeostasis
HPE50_RS03080	COG1595	DNA-templated transcription, initiation
HPE50_RS03120	COG4372	Transposase
HPE50_RS03125	COG3436	PFAM IS66 Orf2 family protein
HPE50_RS03165	COG4983	Phage plasmid primase, P4 family domain protein
HPE50_RS03175	COG3468	outer membrane autotransporter barrel domain protein
HPE50_RS03180	COG2020	methyltransferase activity
HPE50_RS03205	COG2003	Belongs to the UPF0758 family
HPE50_RS03245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPE50_RS03285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPE50_RS03295	COG4974	Belongs to the 'phage' integrase family
HPE50_RS03305	COG3539	Fimbrial protein
HPE50_RS03310	COG3121	Chaperone
HPE50_RS03315	COG3188	usher protein
HPE50_RS03320	COG3539	Fimbrial protein
HPE50_RS03325	COG3539	Fimbrial protein
HPE50_RS03330	COG3539	Fimbrial protein
HPE50_RS03335	COG2610	gluconate transmembrane transporter activity
HPE50_RS03345	COG0246	Mannitol dehydrogenase
HPE50_RS03350	COG2186	Transcriptional regulator
HPE50_RS03370	COG2814	Major facilitator Superfamily
HPE50_RS03375	COG2733	membrane
HPE50_RS03380	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HPE50_RS03385	COG1924	4 iron, 4 sulfur cluster binding
HPE50_RS03400	COG0477	Major facilitator Superfamily
HPE50_RS03410	COG3366	ferrous iron transmembrane transporter activity
HPE50_RS03415	COG0700	Nucleoside recognition
HPE50_RS03420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPE50_RS03425	COG0583	DNA-binding transcription factor activity
HPE50_RS03465	COG0523	cobalamin synthesis protein
HPE50_RS03470	COG2879	small protein
HPE50_RS03475	COG1966	Carbon starvation protein
HPE50_RS03480	COG0840	transmembrane signaling receptor activity
HPE50_RS03485	COG2271	Major facilitator Superfamily
HPE50_RS03490	COG3039	Transposase
HPE50_RS03495	COG1063	alcohol dehydrogenase
HPE50_RS03510	COG1484	DNA-dependent DNA replication
HPE50_RS03525	COG2966	Psort location CytoplasmicMembrane, score
HPE50_RS03530	COG2197	response regulator
HPE50_RS03535	COG2197	response regulator
HPE50_RS03540	COG4114	ferric iron reductase
HPE50_RS03575	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HPE50_RS03580	COG0456	acetyltransferase
HPE50_RS03585	COG1011	Hydrolase
HPE50_RS03595	COG2823	Periplasmic or secreted lipoprotein
HPE50_RS03605	COG4667	esterase of the alpha-beta hydrolase superfamily
HPE50_RS03610	COG0084	hydrolase, TatD family'
HPE50_RS03615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPE50_RS03620	COG1328	CTP reductase activity
HPE50_RS03645	COG3550	peptidyl-serine autophosphorylation
HPE50_RS03655	COG3726	membrane protein affecting hemolysin expression
HPE50_RS03660	COG0560	Phosphoserine phosphatase
HPE50_RS03665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPE50_RS03670	COG1056	cytidyltransferase-related domain
HPE50_RS03670	COG3172	ATPase kinase involved in NAD metabolism
HPE50_RS03680	COG0488	(ABC) transporter
HPE50_RS03685	COG0741	lytic transglycosylase activity
HPE50_RS03705	COG2207	Transcriptional regulator
HPE50_RS03705	COG3708	Transcriptional regulator
HPE50_RS03710	COG3045	CreA protein
HPE50_RS03715	COG0745	RESPONSE REGULATOR receiver
HPE50_RS03720	COG2205	protein histidine kinase activity
HPE50_RS03725	COG4452	Inner membrane protein CreD
HPE50_RS03730	COG0745	RESPONSE REGULATOR receiver
HPE50_RS03740	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HPE50_RS03750	COG0460	homoserine dehydrogenase
HPE50_RS03750	COG0527	aspartate kinase activity
HPE50_RS03760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPE50_RS03775	COG1115	amino acid carrier protein
HPE50_RS03785	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPE50_RS03790	COG3385	transposase activity
HPE50_RS03795	COG1584	GPR1 FUN34 yaaH family protein
HPE50_RS03800	COG4735	regulation of single-species biofilm formation
HPE50_RS03830	COG3119	arylsulfatase activity
HPE50_RS03845	COG0583	DNA-binding transcription factor activity
HPE50_RS03855	COG3188	usher protein
HPE50_RS03860	COG3121	Chaperone
HPE50_RS03885	COG0196	riboflavin kinase activity
HPE50_RS03900	COG1047	Peptidyl-prolyl cis-trans
HPE50_RS03920	COG0505	Belongs to the CarA family
HPE50_RS03925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPE50_RS03975	COG0644	oxidoreductase
HPE50_RS03980	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HPE50_RS03985	COG2271	Major facilitator Superfamily
HPE50_RS04000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPE50_RS04035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPE50_RS04040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPE50_RS04045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPE50_RS04050	COG0564	pseudouridine synthase activity
HPE50_RS04060	COG0417	DNA replication proofreading
HPE50_RS04065	COG0235	Class ii aldolase
HPE50_RS04080	COG4977	sequence-specific DNA binding
HPE50_RS04085	COG0586	Pfam SNARE associated Golgi protein
HPE50_RS04095	COG1178	ABC-type Fe3 transport system permease component
HPE50_RS04100	COG4143	(ABC) transporter
HPE50_RS04110	COG4533	DNA binding
HPE50_RS04145	COG0583	DNA-binding transcription factor activity
HPE50_RS04155	COG0028	Belongs to the TPP enzyme family
HPE50_RS04160	COG0440	acetolactate synthase activity
HPE50_RS04170	COG1609	Transcriptional regulator
HPE50_RS04185	COG3116	cell division
HPE50_RS04190	COG0768	penicillin binding
HPE50_RS04195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPE50_RS04200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPE50_RS04215	COG0772	Belongs to the SEDS family
HPE50_RS04230	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPE50_RS04235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPE50_RS04240	COG0849	cell division
HPE50_RS04245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPE50_RS04265	COG0494	nUDIX hydrolase
HPE50_RS04280	COG0237	dephospho-CoA kinase activity
HPE50_RS04290	COG1459	type II secretion system
HPE50_RS04295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPE50_RS04300	COG4969	Belongs to the N-Me-Phe pilin family
HPE50_RS04305	COG0157	Belongs to the NadC ModD family
HPE50_RS04310	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPE50_RS04315	COG3725	Membrane protein required for beta-lactamase induction
HPE50_RS04320	COG1113	amino acid transport
HPE50_RS04325	COG3039	Transposase
HPE50_RS04360	COG2186	Transcriptional regulator
HPE50_RS04365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPE50_RS04370	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPE50_RS04375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPE50_RS04380	COG3064	Membrane
HPE50_RS04385	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPE50_RS04410	COG2132	Multicopper oxidase
HPE50_RS04415	COG4993	Dehydrogenase
HPE50_RS04420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HPE50_RS04425	COG0288	reversible hydration of carbon dioxide
HPE50_RS04430	COG1131	(ABC) transporter
HPE50_RS04435	COG0842	Transport permease protein
HPE50_RS04440	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS04445	COG0726	polysaccharide deacetylase
HPE50_RS04455	COG5464	transposase or invertase
HPE50_RS04460	COG5464	transposase or invertase
HPE50_RS04490	COG3539	Fimbrial protein
HPE50_RS04495	COG3539	Fimbrial protein
HPE50_RS04505	COG3188	usher protein
HPE50_RS04510	COG3121	Chaperone
HPE50_RS04515	COG3539	Fimbrial protein
HPE50_RS04520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPE50_RS04525	COG0617	tRNA 3'-terminal CCA addition
HPE50_RS04530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPE50_RS04535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPE50_RS04545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HPE50_RS04550	COG1643	Atp-dependent helicase
HPE50_RS04555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPE50_RS04560	COG4774	siderophore transport
HPE50_RS04565	COG1120	ATPase activity
HPE50_RS04570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPE50_RS04575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPE50_RS04600	COG2860	membrane
HPE50_RS04605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPE50_RS04620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPE50_RS04625	COG3835	regulator
HPE50_RS04645	COG0024	Methionine aminopeptidase
HPE50_RS04670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPE50_RS04675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPE50_RS04680	COG0575	Belongs to the CDS family
HPE50_RS04685	COG0750	zinc metalloprotease
HPE50_RS04695	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPE50_RS04700	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPE50_RS04725	COG0587	DNA-directed DNA polymerase activity
HPE50_RS04735	COG3385	transposase activity
HPE50_RS04745	COG0346	lactoylglutathione lyase activity
HPE50_RS04750	COG0037	tRNA processing
HPE50_RS04755	COG4568	rho-dependent transcription termination
HPE50_RS04765	COG4681	YaeQ
HPE50_RS04770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPE50_RS04775	COG3015	lipoprotein NlpE involved in copper resistance
HPE50_RS04780	COG0791	NLP P60 protein
HPE50_RS04790	COG1720	tRNA m6t6A37 methyltransferase activity
HPE50_RS04800	COG1464	Belongs to the NlpA lipoprotein family
HPE50_RS04805	COG2011	ABC-type metal ion transport system permease component
HPE50_RS04810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPE50_RS04815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPE50_RS04865	COG0583	DNA-binding transcription factor activity
HPE50_RS04875	COG2226	methyltransferase
HPE50_RS04880	COG1388	LysM domain
HPE50_RS04880	COG0741	lytic transglycosylase activity
HPE50_RS04890	COG2226	methyltransferase
HPE50_RS04900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPE50_RS04910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPE50_RS04920	COG1960	acyl-CoA dehydrogenase activity
HPE50_RS04930	COG0121	glutamine amidotransferase
HPE50_RS04935	COG3034	peptidoglycan biosynthetic process
HPE50_RS04940	COG3041	Addiction module toxin RelE StbE family
HPE50_RS04945	COG3077	Addiction module antitoxin, RelB DinJ family
HPE50_RS04950	COG0791	NLP P60 protein
HPE50_RS04955	COG1943	Transposase
HPE50_RS04975	COG1987	bacterial-type flagellum assembly
HPE50_RS05000	COG1677	Flagellar hook-basal body complex protein FliE
HPE50_RS05010	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPE50_RS05030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPE50_RS05060	COG1815	bacterial-type flagellum-dependent cell motility
HPE50_RS05065	COG1558	bacterial-type flagellum-dependent cell motility
HPE50_RS05075	COG1749	Flagellar hook protein flgE
HPE50_RS05080	COG4787	bacterial-type flagellum-dependent cell motility
HPE50_RS05085	COG4786	Flagellar basal body rod
HPE50_RS05110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPE50_RS05125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPE50_RS05130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPE50_RS05155	COG1191	sigma factor activity
HPE50_RS05160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPE50_RS05175	COG2161	toxin-antitoxin pair type II binding
HPE50_RS05185	COG0454	-acetyltransferase
HPE50_RS05190	COG1690	Belongs to the RtcB family
HPE50_RS05195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPE50_RS05200	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPE50_RS05220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPE50_RS05240	COG0582	viral genome integration into host DNA
HPE50_RS05375	COG0727	PFAM Uncharacterised protein family (UPF0153)
HPE50_RS05380	COG3477	response to acidic pH
HPE50_RS05455	COG0667	Aldo Keto reductase
HPE50_RS05460	COG0656	L-ascorbic acid biosynthetic process
HPE50_RS05465	COG1388	LysM domain
HPE50_RS05470	COG3708	Transcriptional regulator
HPE50_RS05470	COG2207	Transcriptional regulator
HPE50_RS05475	COG0656	L-ascorbic acid biosynthetic process
HPE50_RS05480	COG3059	membrane
HPE50_RS05490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPE50_RS05495	COG2207	Transcriptional regulator
HPE50_RS05500	COG0247	lactate metabolic process
HPE50_RS05505	COG1139	Iron-sulfur cluster binding protein
HPE50_RS05510	COG1556	Lactate utilization protein
HPE50_RS05525	COG2223	nitrite transmembrane transporter activity
HPE50_RS05535	COG1609	Transcriptional regulator
HPE50_RS05540	COG1414	Transcriptional regulator
HPE50_RS05575	COG2814	Major facilitator Superfamily
HPE50_RS05580	COG3122	Protein conserved in bacteria
HPE50_RS05610	COG1215	transferase activity, transferring glycosyl groups
HPE50_RS05615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPE50_RS05620	COG4521	taurine ABC transporter
HPE50_RS05625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPE50_RS05630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPE50_RS05635	COG2175	clavaminate synthase activity
HPE50_RS05640	COG0113	porphobilinogen synthase activity
HPE50_RS05645	COG3468	outer membrane autotransporter barrel domain protein
HPE50_RS05650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPE50_RS05655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPE50_RS05660	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HPE50_RS05680	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPE50_RS05695	COG1785	Belongs to the alkaline phosphatase family
HPE50_RS05705	COG3706	GGDEF domain
HPE50_RS05710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPE50_RS05730	COG4126	flavin adenine dinucleotide binding
HPE50_RS05755	COG1940	carbohydrate kinase activity
HPE50_RS05775	COG0419	ATPase involved in DNA repair
HPE50_RS05780	COG0420	3'-5' exonuclease activity
HPE50_RS05785	COG0745	RESPONSE REGULATOR receiver
HPE50_RS05790	COG5002	protein histidine kinase activity
HPE50_RS05795	COG1114	Component of the transport system for branched-chain amino acids
HPE50_RS05800	COG1113	amino acid transport
HPE50_RS05805	COG0366	Alpha amylase catalytic
HPE50_RS05830	COG1862	Preprotein translocase
HPE50_RS05835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPE50_RS05840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPE50_RS05845	COG3609	addiction module antidote protein, CC2985 family
HPE50_RS05855	COG1403	HNH endonuclease
HPE50_RS05860	COG3248	Nucleoside-binding outer membrane protein
HPE50_RS05875	COG0675	Transposase, IS605 OrfB family
HPE50_RS05890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPE50_RS05890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPE50_RS05905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPE50_RS05910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPE50_RS05915	COG0667	Aldo Keto reductase
HPE50_RS05925	COG0142	geranyltranstransferase activity
HPE50_RS05940	COG0693	protein deglycase activity
HPE50_RS05945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPE50_RS05955	COG2814	Major facilitator Superfamily
HPE50_RS05980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPE50_RS05985	COG1845	cytochrome c oxidase, subunit III
HPE50_RS05990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPE50_RS05995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPE50_RS06000	COG2223	nitrite transmembrane transporter activity
HPE50_RS06005	COG3056	Lipoprotein
HPE50_RS06010	COG0271	Belongs to the BolA IbaG family
HPE50_RS06030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPE50_RS06035	COG0776	regulation of translation
HPE50_RS06040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPE50_RS06045	COG1555	photosystem II stabilization
HPE50_RS06050	COG0824	Thioesterase
HPE50_RS06065	COG4533	DNA binding
HPE50_RS06075	COG1522	sequence-specific DNA binding
HPE50_RS06080	COG1132	(ABC) transporter
HPE50_RS06085	COG1132	(ABC) transporter
HPE50_RS06090	COG0347	Belongs to the P(II) protein family
HPE50_RS06095	COG0004	ammonium transporteR
HPE50_RS06100	COG1946	Acyl-CoA thioesterase
HPE50_RS06105	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HPE50_RS06110	COG3695	enzyme binding
HPE50_RS06120	COG5507	3-demethylubiquinone-9 3-methyltransferase
HPE50_RS06125	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HPE50_RS06135	COG0110	maltose O-acetyltransferase activity
HPE50_RS06150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPE50_RS06155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPE50_RS06160	COG1309	transcriptional regulator
HPE50_RS06165	COG1196	nuclear chromosome segregation
HPE50_RS06165	COG3264	Mechanosensitive ion channel
HPE50_RS06175	COG3923	Primosomal replication protein n
HPE50_RS06180	COG2832	Protein of unknown function (DUF454)
HPE50_RS06190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPE50_RS06225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS06230	COG4651	solute:proton antiporter activity
HPE50_RS06230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPE50_RS06250	COG0737	Belongs to the 5'-nucleotidase family
HPE50_RS06255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPE50_RS06260	COG3735	TraB family
HPE50_RS06270	COG2217	Heavy metal translocating P-type atpase
HPE50_RS06280	COG0531	amino acid
HPE50_RS06305	COG0789	Transcriptional regulator
HPE50_RS06335	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPE50_RS06340	COG0330	HflC and HflK could
HPE50_RS06345	COG4619	ABC transporter
HPE50_RS06350	COG0390	transport system, permease component
HPE50_RS06355	COG3118	belongs to the thioredoxin family
HPE50_RS06360	COG0300	oxidoreductase activity
HPE50_RS06365	COG2755	lipolytic protein G-D-S-L family
HPE50_RS06370	COG4181	ATPase activity
HPE50_RS06375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPE50_RS06385	COG0583	DNA-binding transcription factor activity
HPE50_RS06395	COG1414	Transcriptional regulator
HPE50_RS06400	COG3960	tartronate-semialdehyde synthase activity
HPE50_RS06405	COG3622	Belongs to the hyi family
HPE50_RS06410	COG2084	Dehydrogenase
HPE50_RS06415	COG1953	Uracil, thiamine, allantoin
HPE50_RS06425	COG2233	PERMEase
HPE50_RS06430	COG1929	Belongs to the glycerate kinase type-1 family
HPE50_RS06445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPE50_RS06455	COG0549	Belongs to the carbamate kinase family
HPE50_RS06460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPE50_RS06465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPE50_RS06475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPE50_RS06485	COG1988	membrane-bound metal-dependent
HPE50_RS06490	COG2501	S4 domain
HPE50_RS06500	COG3539	Fimbrial protein
HPE50_RS06505	COG3121	Chaperone
HPE50_RS06510	COG3188	usher protein
HPE50_RS06515	COG3539	Fimbrial protein
HPE50_RS06520	COG3539	Fimbrial protein
HPE50_RS06525	COG2197	response regulator
HPE50_RS06535	COG0582	viral genome integration into host DNA
HPE50_RS06550	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPE50_RS06575	COG3772	lysozyme
HPE50_RS06605	COG4220	transposase activity
HPE50_RS06625	COG1030	water channel activity
HPE50_RS06675	COG1196	nuclear chromosome segregation
HPE50_RS06710	COG5301	cellulose 1,4-beta-cellobiosidase activity
HPE50_RS06735	COG0500	methyltransferase
HPE50_RS06750	COG4571	Outer membrane protease
HPE50_RS06755	COG2207	Transcriptional regulator
HPE50_RS06765	COG4783	chaperone-mediated protein folding
HPE50_RS06770	COG1215	transferase activity, transferring glycosyl groups
HPE50_RS06775	COG5002	protein histidine kinase activity
HPE50_RS06780	COG0745	RESPONSE REGULATOR receiver
HPE50_RS06785	COG1538	Outer membrane efflux protein
HPE50_RS06790	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPE50_RS06795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPE50_RS06800	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPE50_RS06805	COG1113	amino acid transport
HPE50_RS06810	COG0668	transmembrane transport
HPE50_RS06815	COG0778	Nitroreductase
HPE50_RS06820	COG2315	Protein conserved in bacteria
HPE50_RS06850	COG2977	Belongs to the P-Pant transferase superfamily
HPE50_RS06855	COG4771	TonB-dependent receptor
HPE50_RS06860	COG2382	esterase
HPE50_RS06865	COG3251	PFAM MbtH domain protein
HPE50_RS06870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPE50_RS06870	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HPE50_RS06875	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPE50_RS06880	COG1120	ATPase activity
HPE50_RS06885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPE50_RS06890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPE50_RS06900	COG4592	Periplasmic binding protein
HPE50_RS06905	COG1169	isochorismate synthase
HPE50_RS06910	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPE50_RS06915	COG1535	isochorismatase
HPE50_RS06915	COG3433	isochorismatase activity
HPE50_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS06925	COG2050	protein possibly involved in aromatic compounds catabolism
HPE50_RS06930	COG1966	Carbon starvation protein
HPE50_RS06935	COG2879	small protein
HPE50_RS06940	COG0371	Dehydrogenase
HPE50_RS06945	COG0436	Aminotransferase
HPE50_RS06950	COG1475	DNA binding
HPE50_RS06955	COG3969	phosphoadenosine phosphosulfate
HPE50_RS06960	COG0583	DNA-binding transcription factor activity
HPE50_RS06965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPE50_RS06970	COG0450	alkyl hydroperoxide reductase
HPE50_RS06975	COG3634	alkyl hydroperoxide reductase activity
HPE50_RS06980	COG0589	response to stress
HPE50_RS06985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPE50_RS06990	COG3719	Belongs to the RNase T2 family
HPE50_RS06995	COG0471	metal ion transport
HPE50_RS07010	COG3051	citrate lyase alpha subunit
HPE50_RS07015	COG2301	Belongs to the HpcH HpaI aldolase family
HPE50_RS07025	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPE50_RS07030	COG3290	protein histidine kinase activity
HPE50_RS07035	COG4565	transcriptional regulatory protein
HPE50_RS07040	COG3069	C4-dicarboxylate transmembrane transporter activity
HPE50_RS07060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPE50_RS07065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPE50_RS07075	COG0583	DNA-binding transcription factor activity
HPE50_RS07095	COG1686	Belongs to the peptidase S11 family
HPE50_RS07100	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPE50_RS07105	COG0772	Belongs to the SEDS family
HPE50_RS07110	COG0768	penicillin binding
HPE50_RS07120	COG0799	negative regulation of ribosome biogenesis
HPE50_RS07125	COG0406	alpha-ribazole phosphatase activity
HPE50_RS07135	COG1466	dna polymerase III delta subunit
HPE50_RS07150	COG2888	peptidyl-tyrosine sulfation
HPE50_RS07160	COG1126	abc transporter atp-binding protein
HPE50_RS07165	COG0765	amino acid transport
HPE50_RS07170	COG0765	amino acid transport
HPE50_RS07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPE50_RS07185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPE50_RS07190	COG4535	Mg2 and Co2 transporter CorC
HPE50_RS07200	COG1702	phosphate starvation-inducible protein PhoH
HPE50_RS07210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPE50_RS07255	COG0367	asparagine synthase
HPE50_RS07260	COG0647	UMP catabolic process
HPE50_RS07265	COG1940	carbohydrate kinase activity
HPE50_RS07265	COG1846	Transcriptional regulator
HPE50_RS07270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPE50_RS07280	COG1263	PTS System
HPE50_RS07280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS07280	COG2190	(PTS) system
HPE50_RS07300	COG0735	belongs to the Fur family
HPE50_RS07310	COG0716	FMN binding
HPE50_RS07320	COG0596	Alpha beta hydrolase
HPE50_RS07325	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPE50_RS07330	COG0033	Phosphoglucomutase
HPE50_RS07335	COG0531	amino acid
HPE50_RS07340	COG1982	Orn Lys Arg decarboxylase major
HPE50_RS07350	COG0745	RESPONSE REGULATOR receiver
HPE50_RS07355	COG2205	protein histidine kinase activity
HPE50_RS07385	COG3272	Protein of unknown function (DUF1722)
HPE50_RS07390	COG0415	Belongs to the DNA photolyase family
HPE50_RS07400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPE50_RS07405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPE50_RS07410	COG1984	allophanate hydrolase subunit 2
HPE50_RS07425	COG3180	Ammonia monooxygenase
HPE50_RS07435	COG0372	Belongs to the citrate synthase family
HPE50_RS07445	COG2009	succinate dehydrogenase
HPE50_RS07450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPE50_RS07455	COG1053	succinate dehydrogenase
HPE50_RS07460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPE50_RS07465	COG0567	Dehydrogenase, E1 component
HPE50_RS07470	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPE50_RS07480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPE50_RS07500	COG0583	DNA-binding transcription factor activity
HPE50_RS07505	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPE50_RS07510	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HPE50_RS07510	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPE50_RS07515	COG1301	dicarboxylic acid transport
HPE50_RS07530	COG3799	methylaspartate ammonia-lyase activity
HPE50_RS07535	COG4865	methylaspartate mutase activity
HPE50_RS07545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPE50_RS07560	COG1271	oxidase subunit
HPE50_RS07565	COG1294	oxidase, subunit
HPE50_RS07570	COG4890	Cyd operon protein YbgT
HPE50_RS07575	COG3790	cyd operon protein YbgE
HPE50_RS07580	COG0824	Thioesterase
HPE50_RS07585	COG0811	peptide transport
HPE50_RS07590	COG0848	biopolymer transport protein
HPE50_RS07595	COG3064	Membrane
HPE50_RS07605	COG2885	chlorophyll binding
HPE50_RS07610	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HPE50_RS07660	COG3201	nicotinamide mononucleotide transporter
HPE50_RS07665	COG1230	cation diffusion facilitator family transporter
HPE50_RS07675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPE50_RS07685	COG2017	converts alpha-aldose to the beta-anomer
HPE50_RS07695	COG1085	galactose-1-phosphate uridylyltransferase
HPE50_RS07700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPE50_RS07705	COG1119	ATPase activity
HPE50_RS07710	COG3585	molybdate ion transport
HPE50_RS07710	COG2005	Transcriptional regulator
HPE50_RS07720	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPE50_RS07725	COG4149	molybdate abc transporter
HPE50_RS07735	COG0561	phosphatase activity
HPE50_RS07750	COG2828	Protein conserved in bacteria
HPE50_RS07755	COG0471	metal ion transport
HPE50_RS07760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPE50_RS07765	COG4677	pectinesterase activity
HPE50_RS07770	COG1881	PFAM PEBP family protein
HPE50_RS07775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPE50_RS07790	COG2226	methyltransferase
HPE50_RS07795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPE50_RS07805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPE50_RS07815	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPE50_RS07825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPE50_RS07830	COG0314	molybdopterin synthase activity
HPE50_RS07835	COG0670	Belongs to the BI1 family
HPE50_RS07840	COG0670	Belongs to the BI1 family
HPE50_RS07845	COG0392	lysyltransferase activity
HPE50_RS07850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPE50_RS07855	COG3568	Endonuclease Exonuclease Phosphatase
HPE50_RS07865	COG0842	Transport permease protein
HPE50_RS07870	COG0842	Transport permease protein
HPE50_RS07875	COG1131	(ABC) transporter
HPE50_RS07885	COG1309	transcriptional regulator
HPE50_RS07890	COG0513	Belongs to the DEAD box helicase family
HPE50_RS07900	COG1199	ATP-dependent helicase activity
HPE50_RS07905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPE50_RS07910	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPE50_RS07920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPE50_RS07930	COG4774	siderophore transport
HPE50_RS07945	COG0668	transmembrane transport
HPE50_RS07950	COG1126	abc transporter atp-binding protein
HPE50_RS07955	COG0765	amino acid transport
HPE50_RS07960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPE50_RS07970	COG5006	permease, DMT superfamily
HPE50_RS07980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HPE50_RS07985	COG2194	sulfuric ester hydrolase activity
HPE50_RS07995	COG1321	iron dependent repressor
HPE50_RS08000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPE50_RS08005	COG1376	ErfK ybiS ycfS ynhG family protein
HPE50_RS08010	COG0488	(ABC) transporter
HPE50_RS08020	COG2271	Major facilitator Superfamily
HPE50_RS08035	COG0561	phosphatase activity
HPE50_RS08040	COG1882	Formate acetyltransferase
HPE50_RS08045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPE50_RS08050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPE50_RS08055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPE50_RS08060	COG0303	'Molybdopterin
HPE50_RS08065	COG1446	asparaginase
HPE50_RS08075	COG0747	negative chemotaxis
HPE50_RS08090	COG2200	EAL domain
HPE50_RS08095	COG2199	diguanylate cyclase activity
HPE50_RS08120	COG2133	pyrroloquinoline quinone binding
HPE50_RS08125	COG0625	glutathione transferase activity
HPE50_RS08130	COG1686	Belongs to the peptidase S11 family
HPE50_RS08135	COG1349	DNA-binding transcription factor activity
HPE50_RS08140	COG0671	phosphoesterase, PA-phosphatase related
HPE50_RS08145	COG2814	Major facilitator Superfamily
HPE50_RS08155	COG0561	phosphatase activity
HPE50_RS08160	COG0738	Major facilitator superfamily
HPE50_RS08165	COG3226	Transcriptional regulator
HPE50_RS08180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPE50_RS08190	COG0778	Nitroreductase
HPE50_RS08205	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPE50_RS08210	COG3842	ATPase activity
HPE50_RS08215	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPE50_RS08220	COG1177	transmembrane transport
HPE50_RS08235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPE50_RS08240	COG4160	amino acid transport
HPE50_RS08245	COG4215	(ABC) transporter
HPE50_RS08250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPE50_RS08255	COG1126	abc transporter atp-binding protein
HPE50_RS08275	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPE50_RS08280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPE50_RS08285	COG0702	epimerase
HPE50_RS08290	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPE50_RS08295	COG0028	Belongs to the TPP enzyme family
HPE50_RS08300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPE50_RS08310	COG2431	L-lysine efflux transmembrane transporter activity
HPE50_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS08335	COG0586	Pfam SNARE associated Golgi protein
HPE50_RS08345	COG1686	Belongs to the peptidase S11 family
HPE50_RS08350	COG0277	FAD linked oxidase domain protein
HPE50_RS08355	COG1472	Belongs to the glycosyl hydrolase 3 family
HPE50_RS08360	COG1732	Glycine betaine
HPE50_RS08365	COG1174	glycine betaine transport
HPE50_RS08370	COG1125	glycine betaine transport
HPE50_RS08375	COG1174	glycine betaine transport
HPE50_RS08385	COG0789	Transcriptional regulator
HPE50_RS08390	COG0582	viral genome integration into host DNA
HPE50_RS08440	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPE50_RS08465	COG3646	Phage regulatory protein
HPE50_RS08470	COG3646	Phage regulatory protein
HPE50_RS08480	COG1846	Transcriptional regulator
HPE50_RS08490	COG4725	Belongs to the MT-A70-like family
HPE50_RS08500	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HPE50_RS08510	COG1403	HNH endonuclease
HPE50_RS08530	COG2207	Transcriptional regulator
HPE50_RS08575	COG3772	lysozyme
HPE50_RS08600	COG4220	transposase activity
HPE50_RS08705	COG5301	cellulose 1,4-beta-cellobiosidase activity
HPE50_RS08725	COG3275	phosphorelay sensor kinase activity
HPE50_RS08730	COG3279	Response regulator of the LytR AlgR family
HPE50_RS08735	COG4807	Protein conserved in bacteria
HPE50_RS08740	COG4808	Protein conserved in bacteria
HPE50_RS08745	COG4715	Zinc finger, swim domain protein
HPE50_RS08755	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPE50_RS08760	COG0714	Associated with various cellular activities
HPE50_RS08780	COG3385	transposase activity
HPE50_RS08795	COG0489	protein tyrosine kinase activity
HPE50_RS08820	COG0351	phosphomethylpyrimidine kinase
HPE50_RS08825	COG3757	hydrolase, family 25
HPE50_RS08830	COG2188	Transcriptional regulator
HPE50_RS08835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS08840	COG1397	ADP-ribosylglycohydrolase
HPE50_RS08845	COG2211	Major facilitator Superfamily
HPE50_RS08855	COG1830	Aldolase
HPE50_RS08885	COG3414	Phosphotransferase system galactitol-specific IIB component
HPE50_RS08890	COG3775	system Galactitol-specific IIC component
HPE50_RS08895	COG1063	alcohol dehydrogenase
HPE50_RS08925	COG3609	addiction module antidote protein, CC2985 family
HPE50_RS08935	COG0745	RESPONSE REGULATOR receiver
HPE50_RS08940	COG2205	protein histidine kinase activity
HPE50_RS08975	COG4245	von Willebrand factor, type A
HPE50_RS08980	COG0631	protein serine/threonine phosphatase activity
HPE50_RS08985	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HPE50_RS08990	COG0443	Heat shock 70 kDa protein
HPE50_RS08995	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPE50_RS09005	COG0572	uridine kinase
HPE50_RS09015	COG2982	Protein involved in outer membrane biogenesis
HPE50_RS09030	COG1253	flavin adenine dinucleotide binding
HPE50_RS09040	COG1596	polysaccharide export
HPE50_RS09045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPE50_RS09050	COG3206	protein involved in exopolysaccharide biosynthesis
HPE50_RS09050	COG0489	protein tyrosine kinase activity
HPE50_RS09055	COG0463	Glycosyl transferase, family 2
HPE50_RS09060	COG1045	serine acetyltransferase
HPE50_RS09065	COG0438	transferase activity, transferring glycosyl groups
HPE50_RS09075	COG1216	Glycosyl transferase, family 2
HPE50_RS09080	COG0110	maltose O-acetyltransferase activity
HPE50_RS09085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPE50_RS09090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPE50_RS09095	COG1051	belongs to the nudix hydrolase family
HPE50_RS09100	COG0297	glycogen (starch) synthase activity
HPE50_RS09105	COG0662	Cupin 2, conserved barrel domain protein
HPE50_RS09105	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HPE50_RS09110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPE50_RS09115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPE50_RS09120	COG2244	polysaccharide biosynthetic process
HPE50_RS09125	COG2327	Polysaccharide pyruvyl transferase
HPE50_RS09130	COG0438	transferase activity, transferring glycosyl groups
HPE50_RS09140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPE50_RS09145	COG1088	dTDP-glucose 4,6-dehydratase activity
HPE50_RS09150	COG1091	dTDP-4-dehydrorhamnose reductase activity
HPE50_RS09155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPE50_RS09170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPE50_RS09185	COG0463	Glycosyl transferase, family 2
HPE50_RS09195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPE50_RS09200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPE50_RS09205	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPE50_RS09210	COG0140	phosphoribosyl-ATP diphosphatase activity
HPE50_RS09210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPE50_RS09225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPE50_RS09230	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPE50_RS09230	COG0131	Imidazoleglycerol-phosphate dehydratase
HPE50_RS09240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPE50_RS09255	COG2161	toxin-antitoxin pair type II binding
HPE50_RS09260	COG4115	mRNA cleavage
HPE50_RS09265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPE50_RS09270	COG0583	DNA-binding transcription factor activity
HPE50_RS09280	COG0531	amino acid
HPE50_RS09285	COG2391	methyltransferase activity
HPE50_RS09290	COG0425	Belongs to the sulfur carrier protein TusA family
HPE50_RS09295	COG2925	Exonuclease
HPE50_RS09300	COG1686	Belongs to the peptidase S11 family
HPE50_RS09320	COG1289	transmembrane transporter activity
HPE50_RS09365	COG2003	Belongs to the UPF0758 family
HPE50_RS09380	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HPE50_RS09395	COG1376	ErfK ybiS ycfS ynhG family protein
HPE50_RS09405	COG0583	DNA-binding transcription factor activity
HPE50_RS09410	COG0583	DNA-binding transcription factor activity
HPE50_RS09420	COG0534	Mate efflux family protein
HPE50_RS09430	COG0217	transcriptional regulatory protein
HPE50_RS09435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPE50_RS09440	COG0477	Major facilitator Superfamily
HPE50_RS09450	COG1470	cell adhesion involved in biofilm formation
HPE50_RS09450	COG1388	LysM domain
HPE50_RS09455	COG1388	LysM domain
HPE50_RS09455	COG1470	cell adhesion involved in biofilm formation
HPE50_RS09460	COG1388	LysM domain
HPE50_RS09460	COG2373	Large extracellular alpha-helical protein
HPE50_RS09460	COG4932	domain protein
HPE50_RS09465	COG4771	TonB-dependent receptor
HPE50_RS09470	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPE50_RS09505	COG1132	(ABC) transporter
HPE50_RS09510	COG2814	Major facilitator Superfamily
HPE50_RS09515	COG1169	isochorismate synthase
HPE50_RS09520	COG0582	viral genome integration into host DNA
HPE50_RS09550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPE50_RS09580	COG1396	sequence-specific DNA binding
HPE50_RS09605	COG1846	Transcriptional regulator
HPE50_RS09665	COG1403	HNH endonuclease
HPE50_RS09670	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HPE50_RS09675	COG0484	heat shock protein binding
HPE50_RS09725	COG3772	lysozyme
HPE50_RS09755	COG4220	transposase activity
HPE50_RS09860	COG5301	cellulose 1,4-beta-cellobiosidase activity
HPE50_RS09875	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPE50_RS09890	COG2351	hydroxyisourate hydrolase activity
HPE50_RS09895	COG0745	RESPONSE REGULATOR receiver
HPE50_RS09900	COG2205	protein histidine kinase activity
HPE50_RS09910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPE50_RS09920	COG1418	mRNA catabolic process
HPE50_RS09925	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPE50_RS09930	COG3727	T/G mismatch-specific endonuclease activity
HPE50_RS09935	COG0697	spore germination
HPE50_RS09940	COG2354	Protein conserved in bacteria
HPE50_RS09945	COG5475	Uncharacterized small protein (DUF2158)
HPE50_RS09970	COG4382	Mu-like prophage protein Gp16
HPE50_RS10005	COG4396	Host-nuclease inhibitor protein Gam
HPE50_RS10015	COG3267	Type II secretory pathway component ExeA
HPE50_RS10015	COG3409	Peptidoglycan-binding domain 1 protein
HPE50_RS10090	COG4373	Mu-like prophage FluMu protein gp28
HPE50_RS10100	COG2369	cell adhesion
HPE50_RS10220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPE50_RS10245	COG2197	response regulator
HPE50_RS10260	COG2135	peptidase activity
HPE50_RS10265	COG0425	Belongs to the sulfur carrier protein TusA family
HPE50_RS10270	COG2391	methyltransferase activity
HPE50_RS10280	COG0366	Alpha amylase catalytic
HPE50_RS10290	COG1516	flagellar protein fliS
HPE50_RS10295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPE50_RS10305	COG1191	sigma factor activity
HPE50_RS10335	COG2197	response regulator
HPE50_RS10350	COG2197	response regulator
HPE50_RS10380	COG3012	SEC-C Motif Domain Protein
HPE50_RS10380	COG3318	Belongs to the UPF0149 family
HPE50_RS10385	COG0814	amino acid
HPE50_RS10395	COG1528	Iron-storage protein
HPE50_RS10415	COG1528	Iron-storage protein
HPE50_RS10420	COG1879	ABC-type sugar transport system periplasmic component
HPE50_RS10430	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPE50_RS10435	COG1877	trehalose-phosphatase activity
HPE50_RS10445	COG0589	response to stress
HPE50_RS10465	COG3385	transposase activity
HPE50_RS10475	COG1360	Flagellar Motor Protein
HPE50_RS10480	COG2198	Histidine kinase
HPE50_RS10480	COG0643	Histidine kinase
HPE50_RS10485	COG0835	chemotaxis
HPE50_RS10490	COG0840	transmembrane signaling receptor activity
HPE50_RS10500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPE50_RS10510	COG0745	RESPONSE REGULATOR receiver
HPE50_RS10515	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPE50_RS10525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPE50_RS10540	COG3102	Protein conserved in bacteria
HPE50_RS10550	COG3005	denitrification pathway
HPE50_RS10555	COG0243	molybdopterin cofactor binding
HPE50_RS10570	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HPE50_RS10575	COG1801	Protein of unknown function DUF72
HPE50_RS10580	COG1335	isochorismatase
HPE50_RS10590	COG0494	nUDIX hydrolase
HPE50_RS10595	COG0217	transcriptional regulatory protein
HPE50_RS10625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPE50_RS10635	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPE50_RS10640	COG0739	heme binding
HPE50_RS10645	COG1560	Kdo2-lipid A biosynthetic process
HPE50_RS10650	COG0469	pyruvate kinase activity
HPE50_RS10655	COG1737	Transcriptional regulator
HPE50_RS10660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPE50_RS10665	COG0129	dihydroxy-acid dehydratase activity
HPE50_RS10670	COG0800	Aldolase
HPE50_RS10680	COG3141	response to X-ray
HPE50_RS10690	COG2979	Protein of unknown function (DUF533)
HPE50_RS10695	COG1770	oligopeptidase
HPE50_RS10700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPE50_RS10705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPE50_RS10715	COG2372	response to copper ion
HPE50_RS10720	COG1276	copper resistance
HPE50_RS10730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPE50_RS10750	COG3008	intermembrane lipid transfer
HPE50_RS10755	COG2995	paraquat-inducible protein a
HPE50_RS10760	COG1956	GAF domain-containing protein
HPE50_RS10770	COG0793	Belongs to the peptidase S41A family
HPE50_RS10780	COG2814	Major facilitator Superfamily
HPE50_RS10785	COG1414	Transcriptional regulator
HPE50_RS10815	COG2226	methyltransferase
HPE50_RS10830	COG3716	PTS system mannose fructose sorbose family IID component
HPE50_RS10835	COG3715	PTS system
HPE50_RS10840	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS10840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS10845	COG1253	flavin adenine dinucleotide binding
HPE50_RS10850	COG2200	EAL domain
HPE50_RS10855	COG1760	l-serine dehydratase
HPE50_RS10860	COG0494	nUDIX hydrolase
HPE50_RS10865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPE50_RS10880	COG0251	oxidation-reduction process
HPE50_RS10885	COG1199	ATP-dependent helicase activity
HPE50_RS10890	COG1214	PFAM Peptidase M22, glycoprotease
HPE50_RS10895	COG3065	identical protein binding
HPE50_RS10900	COG0318	PFAM AMP-dependent synthetase and ligase
HPE50_RS10905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPE50_RS10910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPE50_RS10915	COG4638	Rieske (2fe-2S)
HPE50_RS10920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPE50_RS10925	COG0473	3-isopropylmalate dehydrogenase activity
HPE50_RS10930	COG0583	DNA-binding transcription factor activity
HPE50_RS10940	COG3615	Tellurite resistance protein tehB
HPE50_RS10950	COG2261	transglycosylase associated protein
HPE50_RS10965	COG2199	diguanylate cyclase activity
HPE50_RS10965	COG2203	Gaf domain
HPE50_RS10970	COG3042	response to heat
HPE50_RS10975	COG3189	MarR family transcriptional regulator
HPE50_RS10980	COG2807	transmembrane transport
HPE50_RS10985	COG2207	Transcriptional regulator
HPE50_RS11000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPE50_RS11005	COG2199	diguanylate cyclase activity
HPE50_RS11010	COG2199	diguanylate cyclase activity
HPE50_RS11020	COG2766	serine protein kinase
HPE50_RS11025	COG3713	MltA-interacting MipA family protein
HPE50_RS11030	COG0656	L-ascorbic acid biosynthetic process
HPE50_RS11035	COG0676	glucose-6-phosphate 1-epimerase activity
HPE50_RS11040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPE50_RS11050	COG3139	Protein of unknown function (DUF1315)
HPE50_RS11055	COG1063	alcohol dehydrogenase
HPE50_RS11060	COG2271	Major facilitator Superfamily
HPE50_RS11065	COG1063	alcohol dehydrogenase
HPE50_RS11070	COG0191	fructose-bisphosphate aldolase activity
HPE50_RS11075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS11080	COG0667	Aldo Keto reductase
HPE50_RS11085	COG1349	DNA-binding transcription factor activity
HPE50_RS11090	COG2814	Major facilitator Superfamily
HPE50_RS11095	COG1335	isochorismatase
HPE50_RS11100	COG0252	asparaginase activity
HPE50_RS11105	COG0616	signal peptide processing
HPE50_RS11110	COG0778	Nitroreductase
HPE50_RS11115	COG0709	Synthesizes selenophosphate from selenide and ATP
HPE50_RS11120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPE50_RS11125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPE50_RS11135	COG0494	nUDIX hydrolase
HPE50_RS11140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPE50_RS11145	COG2897	thiosulfate sulfurtransferase activity
HPE50_RS11150	COG4136	ATPase activity
HPE50_RS11155	COG4135	transport system, permease component
HPE50_RS11160	COG4134	Bacterial extracellular solute-binding protein
HPE50_RS11165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPE50_RS11170	COG0398	Pfam SNARE associated Golgi protein
HPE50_RS11180	COG0398	Pfam SNARE associated Golgi protein
HPE50_RS11185	COG0708	Exodeoxyribonuclease III
HPE50_RS11215	COG3678	ATP-independent chaperone mediated protein folding
HPE50_RS11225	COG0322	excinuclease ABC activity
HPE50_RS11235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPE50_RS11240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPE50_RS11245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPE50_RS11250	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPE50_RS11255	COG2169	Transcriptional regulator
HPE50_RS11255	COG1917	Cupin 2, conserved barrel domain protein
HPE50_RS11260	COG1486	melibiose metabolic process
HPE50_RS11270	COG0753	catalase activity
HPE50_RS11290	COG1988	membrane-bound metal-dependent
HPE50_RS11295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPE50_RS11305	COG3001	Fructosamine kinase
HPE50_RS11315	COG1105	Belongs to the carbohydrate kinase PfkB family
HPE50_RS11320	COG3137	Salt-induced outer membrane protein
HPE50_RS11515	COG4695	Portal protein
HPE50_RS11600	COG4974	Belongs to the 'phage' integrase family
HPE50_RS11615	COG0386	Belongs to the glutathione peroxidase family
HPE50_RS11625	COG0791	NLP P60 protein
HPE50_RS11630	COG2200	EAL domain
HPE50_RS11640	COG4256	Hemin uptake protein
HPE50_RS11645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPE50_RS11655	COG0574	Belongs to the PEP-utilizing enzyme family
HPE50_RS11655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPE50_RS11660	COG0471	metal ion transport
HPE50_RS11665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPE50_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS11695	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HPE50_RS11700	COG0644	oxidoreductase
HPE50_RS11705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPE50_RS11710	COG2086	electron transfer activity
HPE50_RS11715	COG1917	Cupin 2, conserved barrel domain protein
HPE50_RS11715	COG2207	Transcriptional regulator
HPE50_RS11730	COG1960	acyl-CoA dehydrogenase activity
HPE50_RS11735	COG4670	ketone body catabolic process
HPE50_RS11750	COG2271	Major facilitator Superfamily
HPE50_RS11755	COG0738	Major facilitator superfamily
HPE50_RS11770	COG0628	permease
HPE50_RS11775	COG0277	FAD linked oxidase domain protein
HPE50_RS11775	COG0247	lactate metabolic process
HPE50_RS11780	COG2050	protein possibly involved in aromatic compounds catabolism
HPE50_RS11790	COG0316	Belongs to the HesB IscA family
HPE50_RS11795	COG0719	Fe-S assembly protein
HPE50_RS11800	COG0396	ATPase activity
HPE50_RS11805	COG0719	Fe-S assembly protein
HPE50_RS11820	COG1376	ErfK ybiS ycfS ynhG family protein
HPE50_RS11825	COG4238	major outer membrane lipoprotein
HPE50_RS11830	COG0469	pyruvate kinase activity
HPE50_RS11840	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS11845	COG2414	aldehyde ferredoxin oxidoreductase
HPE50_RS11855	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS11860	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HPE50_RS11870	COG4529	Protein conserved in bacteria
HPE50_RS11890	COG3468	outer membrane autotransporter barrel domain protein
HPE50_RS11900	COG0307	riboflavin synthase, alpha
HPE50_RS11905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPE50_RS11910	COG2814	Major facilitator Superfamily
HPE50_RS11915	COG0583	DNA-binding transcription factor activity
HPE50_RS11930	COG2814	Major facilitator Superfamily
HPE50_RS11935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPE50_RS11940	COG0791	NLP P60 protein
HPE50_RS11945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPE50_RS11950	COG1201	RNA secondary structure unwinding
HPE50_RS11960	COG0346	lactoylglutathione lyase activity
HPE50_RS11965	COG1902	pentaerythritol trinitrate reductase activity
HPE50_RS11970	COG1309	transcriptional regulator
HPE50_RS11975	COG3313	Fe-S protein
HPE50_RS11980	COG4989	oxidoreductase activity
HPE50_RS11985	COG2032	superoxide dismutase activity
HPE50_RS11990	COG1289	transmembrane transporter activity
HPE50_RS11995	COG1566	PFAM secretion protein HlyD family protein
HPE50_RS12010	COG3133	Outer membrane lipoprotein
HPE50_RS12020	COG3895	Periplasmic Protein
HPE50_RS12035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HPE50_RS12040	COG0625	glutathione transferase activity
HPE50_RS12045	COG3104	oligopeptide transport
HPE50_RS12050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPE50_RS12060	COG4659	FMN binding
HPE50_RS12100	COG0673	inositol 2-dehydrogenase activity
HPE50_RS12110	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPE50_RS12115	COG1263	PTS System
HPE50_RS12115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS12120	COG1609	Transcriptional regulator
HPE50_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS12130	COG1309	transcriptional regulator
HPE50_RS12155	COG5339	Protein conserved in bacteria
HPE50_RS12160	COG1482	cell wall glycoprotein biosynthetic process
HPE50_RS12165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPE50_RS12165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HPE50_RS12170	COG3385	transposase activity
HPE50_RS12180	COG3539	Fimbrial protein
HPE50_RS12185	COG3539	Fimbrial protein
HPE50_RS12190	COG3188	usher protein
HPE50_RS12215	COG3385	transposase activity
HPE50_RS12275	COG3781	membrane
HPE50_RS12285	COG2199	diguanylate cyclase activity
HPE50_RS12295	COG2066	Belongs to the glutaminase family
HPE50_RS12300	COG1012	belongs to the aldehyde dehydrogenase family
HPE50_RS12305	COG0583	DNA-binding transcription factor activity
HPE50_RS12325	COG1846	Transcriptional regulator
HPE50_RS12330	COG4977	sequence-specific DNA binding
HPE50_RS12340	COG2723	6-phospho-beta-galactosidase activity
HPE50_RS12350	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPE50_RS12355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPE50_RS12360	COG3039	Transposase
HPE50_RS12370	COG2188	Transcriptional regulator
HPE50_RS12375	COG0697	spore germination
HPE50_RS12380	COG2814	Major facilitator Superfamily
HPE50_RS12390	COG3706	GGDEF domain
HPE50_RS12395	COG3111	PFAM Bacterial OB fold (BOF) protein
HPE50_RS12400	COG0339	signal peptide processing
HPE50_RS12405	COG4221	oxidoreductase activity
HPE50_RS12410	COG1802	Transcriptional regulator
HPE50_RS12420	COG0246	Mannitol dehydrogenase
HPE50_RS12440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPE50_RS12490	COG2826	transposase and inactivated derivatives, IS30 family
HPE50_RS12545	COG1030	water channel activity
HPE50_RS12565	COG4220	transposase activity
HPE50_RS12575	COG5562	phage envelope protein
HPE50_RS12600	COG1278	Cold shock
HPE50_RS12610	COG3772	lysozyme
HPE50_RS12625	COG1278	Cold shock
HPE50_RS12630	COG1278	Cold shock
HPE50_RS12640	COG0484	heat shock protein binding
HPE50_RS12645	COG1403	HNH endonuclease
HPE50_RS12665	COG2026	Addiction module toxin, RelE StbE family
HPE50_RS12670	COG3077	Addiction module antitoxin, RelB DinJ family
HPE50_RS12685	COG2801	Transposase and inactivated derivatives
HPE50_RS12705	COG1846	Transcriptional regulator
HPE50_RS12720	COG1396	sequence-specific DNA binding
HPE50_RS12750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPE50_RS12760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPE50_RS12770	COG0582	viral genome integration into host DNA
HPE50_RS12780	COG1063	alcohol dehydrogenase
HPE50_RS12785	COG4948	Mandelate Racemase Muconate Lactonizing
HPE50_RS12800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPE50_RS12815	COG0243	molybdopterin cofactor binding
HPE50_RS12820	COG0243	molybdopterin cofactor binding
HPE50_RS12825	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS12830	COG3302	dmso reductase anchor subunit
HPE50_RS12835	COG3381	protein complex oligomerization
HPE50_RS12845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPE50_RS12850	COG1940	carbohydrate kinase activity
HPE50_RS12855	COG0583	DNA-binding transcription factor activity
HPE50_RS12860	COG2814	Major facilitator Superfamily
HPE50_RS12875	COG3591	Belongs to the peptidase S1B family
HPE50_RS12890	COG0628	permease
HPE50_RS12895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPE50_RS12900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPE50_RS12910	COG0531	amino acid
HPE50_RS12920	COG3136	membrane protein required for alginate biosynthesis
HPE50_RS12925	COG0745	RESPONSE REGULATOR receiver
HPE50_RS12930	COG2205	protein histidine kinase activity
HPE50_RS12940	COG0114	fumarate hydratase activity
HPE50_RS12945	COG3385	transposase activity
HPE50_RS12955	COG0243	molybdopterin cofactor binding
HPE50_RS12970	COG3119	arylsulfatase activity
HPE50_RS12975	COG0641	radical SAM
HPE50_RS12985	COG4178	(ABC) transporter
HPE50_RS12990	COG4771	TonB-dependent receptor
HPE50_RS12995	COG0612	Peptidase, M16
HPE50_RS13000	COG0076	glutamate decarboxylase activity
HPE50_RS13005	COG0531	amino acid
HPE50_RS13025	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HPE50_RS13030	COG0747	negative chemotaxis
HPE50_RS13035	COG0601	transmembrane transport
HPE50_RS13040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPE50_RS13045	COG0444	Belongs to the ABC transporter superfamily
HPE50_RS13050	COG4608	Belongs to the ABC transporter superfamily
HPE50_RS13055	COG1764	response to oxidative stress
HPE50_RS13075	COG1064	alcohol dehydrogenase
HPE50_RS13085	COG3093	addiction module antidote protein HigA
HPE50_RS13090	COG2864	formate dehydrogenase
HPE50_RS13095	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS13105	COG0697	spore germination
HPE50_RS13120	COG4886	Leucine-rich repeat (LRR) protein
HPE50_RS13125	COG4886	Leucine-rich repeat (LRR) protein
HPE50_RS13130	COG2223	nitrite transmembrane transporter activity
HPE50_RS13135	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPE50_RS13140	COG1140	nitrate reductase beta subunit
HPE50_RS13145	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPE50_RS13150	COG2181	nitrate reductase activity
HPE50_RS13155	COG0384	phenazine biosynthesis protein PhzF
HPE50_RS13160	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPE50_RS13165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPE50_RS13175	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPE50_RS13190	COG5001	Diguanylate cyclase
HPE50_RS13190	COG4251	negative regulation of phosphorylation
HPE50_RS13190	COG3706	GGDEF domain
HPE50_RS13190	COG2203	Gaf domain
HPE50_RS13200	COG1113	amino acid transport
HPE50_RS13210	COG4772	TonB-dependent receptor
HPE50_RS13220	COG1802	Transcriptional regulator
HPE50_RS13225	COG2130	NADP-dependent
HPE50_RS13230	COG1247	-acetyltransferase
HPE50_RS13235	COG3238	Protein conserved in bacteria
HPE50_RS13265	COG1177	transmembrane transport
HPE50_RS13270	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPE50_RS13275	COG3842	ATPase activity
HPE50_RS13280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPE50_RS13285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPE50_RS13300	COG0826	peptidase U32
HPE50_RS13305	COG1396	sequence-specific DNA binding
HPE50_RS13310	COG3135	benzoate transporter
HPE50_RS13320	COG0500	methyltransferase
HPE50_RS13325	COG1275	C4-dicarboxylate transporter malic acid transport protein
HPE50_RS13330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPE50_RS13335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPE50_RS13340	COG2841	Protein conserved in bacteria
HPE50_RS13350	COG5383	Protein conserved in bacteria
HPE50_RS13355	COG0583	DNA-binding transcription factor activity
HPE50_RS13360	COG0840	transmembrane signaling receptor activity
HPE50_RS13375	COG3038	cytochrome b561
HPE50_RS13380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPE50_RS13385	COG1012	belongs to the aldehyde dehydrogenase family
HPE50_RS13390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPE50_RS13395	COG1643	Atp-dependent helicase
HPE50_RS13405	COG0671	phosphoesterase, PA-phosphatase related
HPE50_RS13405	COG2453	phosphatase
HPE50_RS13410	COG2267	carboxylic ester hydrolase activity
HPE50_RS13415	COG4589	Belongs to the CDS family
HPE50_RS13420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPE50_RS13435	COG3784	Protein of unknown function (DUF1318)
HPE50_RS13445	COG2911	Protein conserved in bacteria
HPE50_RS13450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPE50_RS13455	COG3187	Heat shock protein
HPE50_RS13460	COG3042	response to heat
HPE50_RS13465	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPE50_RS13465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPE50_RS13465	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPE50_RS13465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPE50_RS13480	COG0589	response to stress
HPE50_RS13490	COG1121	(ABC) transporter
HPE50_RS13495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPE50_RS13500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPE50_RS13550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPE50_RS13555	COG3723	Recombinational DNA repair protein, rece pathway
HPE50_RS13585	COG0513	Belongs to the DEAD box helicase family
HPE50_RS13595	COG3706	GGDEF domain
HPE50_RS13600	COG2840	Smr protein MutS2
HPE50_RS13605	COG0583	DNA-binding transcription factor activity
HPE50_RS13610	COG1473	amidohydrolase
HPE50_RS13615	COG1473	amidohydrolase
HPE50_RS13620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPE50_RS13625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPE50_RS13630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPE50_RS13635	COG0589	response to stress
HPE50_RS13640	COG3182	Iron-regulated membrane protein
HPE50_RS13645	COG0668	transmembrane transport
HPE50_RS13650	COG4166	transmembrane transport
HPE50_RS13655	COG2866	Carboxypeptidase
HPE50_RS13660	COG4948	Mandelate Racemase Muconate Lactonizing
HPE50_RS13665	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPE50_RS13670	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HPE50_RS13680	COG3106	COG3106 Predicted ATPase
HPE50_RS13685	COG1609	Transcriptional regulator
HPE50_RS13695	COG3842	ATPase activity
HPE50_RS13715	COG1653	transport
HPE50_RS13720	COG0366	Alpha amylase catalytic
HPE50_RS13725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPE50_RS13735	COG1983	PspC domain protein
HPE50_RS13745	COG1842	Phage shock protein A
HPE50_RS13750	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPE50_RS13755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPE50_RS13760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPE50_RS13765	COG1012	belongs to the aldehyde dehydrogenase family
HPE50_RS13770	COG1396	sequence-specific DNA binding
HPE50_RS13770	COG1917	Cupin 2, conserved barrel domain protein
HPE50_RS13775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HPE50_RS13780	COG0174	glutamine synthetase
HPE50_RS13790	COG0531	amino acid
HPE50_RS13800	COG4166	transmembrane transport
HPE50_RS13805	COG4168	peptide transport system, permease
HPE50_RS13810	COG4171	peptide transport system, permease
HPE50_RS13815	COG4172	Belongs to the ABC transporter superfamily
HPE50_RS13820	COG4172	Belongs to the ABC transporter superfamily
HPE50_RS13825	COG2814	Major facilitator Superfamily
HPE50_RS13835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPE50_RS13840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPE50_RS13850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPE50_RS13870	COG5001	Diguanylate cyclase
HPE50_RS13880	COG1349	DNA-binding transcription factor activity
HPE50_RS13890	COG0023	Translation Initiation Factor
HPE50_RS13900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPE50_RS13905	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPE50_RS13910	COG0671	phosphoesterase, PA-phosphatase related
HPE50_RS13920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPE50_RS13940	COG0583	DNA-binding transcription factor activity
HPE50_RS13945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPE50_RS13955	COG0616	signal peptide processing
HPE50_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS13965	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPE50_RS13985	COG1187	pseudouridine synthase activity
HPE50_RS13990	COG4907	membrane protein (DUF2207)
HPE50_RS13995	COG0009	L-threonylcarbamoyladenylate synthase
HPE50_RS14000	COG0613	PHP domain protein
HPE50_RS14010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPE50_RS14015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPE50_RS14015	COG0512	Glutamine amidotransferase of anthranilate synthase
HPE50_RS14020	COG0135	phosphoribosylanthranilate isomerase activity
HPE50_RS14020	COG0134	indole-3-glycerol-phosphate synthase activity
HPE50_RS14035	COG3729	General stress protein
HPE50_RS14040	COG3685	Protein conserved in bacteria
HPE50_RS14060	COG3772	lysozyme
HPE50_RS14115	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HPE50_RS14120	COG1403	HNH endonuclease
HPE50_RS14140	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPE50_RS14150	COG1846	Transcriptional regulator
HPE50_RS14155	COG1484	DNA-dependent DNA replication
HPE50_RS14160	COG1846	Transcriptional regulator
HPE50_RS14205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPE50_RS14215	COG0582	viral genome integration into host DNA
HPE50_RS14220	COG3047	cAMP biosynthetic process
HPE50_RS14240	COG1607	acyl-coa hydrolase
HPE50_RS14250	COG2350	Protein conserved in bacteria
HPE50_RS14285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPE50_RS14305	COG4608	Belongs to the ABC transporter superfamily
HPE50_RS14310	COG0444	Belongs to the ABC transporter superfamily
HPE50_RS14315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPE50_RS14320	COG0601	transmembrane transport
HPE50_RS14325	COG4166	transmembrane transport
HPE50_RS14335	COG2095	MarC family integral membrane protein
HPE50_RS14340	COG1012	belongs to the aldehyde dehydrogenase family
HPE50_RS14340	COG1454	alcohol dehydrogenase
HPE50_RS14345	COG3385	transposase activity
HPE50_RS14350	COG1435	thymidine kinase activity
HPE50_RS14360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPE50_RS14365	COG0745	RESPONSE REGULATOR receiver
HPE50_RS14370	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPE50_RS14380	COG0788	formyltetrahydrofolate deformylase activity
HPE50_RS14395	COG2181	nitrate reductase activity
HPE50_RS14400	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPE50_RS14405	COG1140	nitrate reductase beta subunit
HPE50_RS14410	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPE50_RS14415	COG2223	nitrite transmembrane transporter activity
HPE50_RS14420	COG3850	Histidine kinase
HPE50_RS14425	COG2197	response regulator
HPE50_RS14430	COG4932	domain protein
HPE50_RS14435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPE50_RS14440	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HPE50_RS14445	COG4572	Cation transport regulator
HPE50_RS14450	COG0387	Pfam Sodium calcium exchanger
HPE50_RS14470	COG2912	Transglutaminase-like superfamily
HPE50_RS14475	COG3094	Invasion gene expression up-regulator, SirB
HPE50_RS14480	COG2890	protein-(glutamine-N5) methyltransferase activity
HPE50_RS14505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPE50_RS14510	COG0659	secondary active sulfate transmembrane transporter activity
HPE50_RS14525	COG0012	GTP binding
HPE50_RS14535	COG3284	Transcriptional regulator
HPE50_RS14540	COG2376	Dihydroxyacetone kinase
HPE50_RS14545	COG1461	Dihydroxyacetone kinase
HPE50_RS14550	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HPE50_RS14550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPE50_RS14550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS14580	COG1120	ATPase activity
HPE50_RS14585	COG0500	methyltransferase
HPE50_RS14590	COG0157	Belongs to the NadC ModD family
HPE50_RS14605	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HPE50_RS14615	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPE50_RS14635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPE50_RS14645	COG2719	SpoVR family
HPE50_RS14660	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPE50_RS14670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPE50_RS14685	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPE50_RS14710	COG2894	cell division
HPE50_RS14760	COG2200	EAL domain
HPE50_RS14785	COG2200	EAL domain
HPE50_RS14790	COG0789	Transcriptional regulator
HPE50_RS14795	COG5562	phage envelope protein
HPE50_RS14810	COG0538	isocitrate dehydrogenase activity
HPE50_RS14825	COG1187	pseudouridine synthase activity
HPE50_RS14845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPE50_RS14855	COG2205	protein histidine kinase activity
HPE50_RS14860	COG2850	peptidyl-arginine hydroxylation
HPE50_RS14870	COG3842	ATPase activity
HPE50_RS14880	COG1177	transmembrane transport
HPE50_RS14885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPE50_RS14895	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPE50_RS14900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPE50_RS14910	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPE50_RS14920	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPE50_RS14925	COG4763	Acyl-transferase
HPE50_RS14930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPE50_RS14935	COG1376	ErfK ybiS ycfS ynhG family protein
HPE50_RS14935	COG1388	LysM domain
HPE50_RS14945	COG1309	transcriptional regulator
HPE50_RS14950	COG3134	Outer membrane lipoprotein
HPE50_RS14955	COG1252	NADH dehydrogenase
HPE50_RS14975	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HPE50_RS14980	COG5633	Lipoprotein
HPE50_RS14985	COG0537	adenosine 5'-monophosphoramidase activity
HPE50_RS14990	COG4773	Receptor
HPE50_RS14995	COG1263	PTS System
HPE50_RS14995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS15000	COG0084	hydrolase, TatD family'
HPE50_RS15005	COG0470	DNA polymerase III
HPE50_RS15015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPE50_RS15020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPE50_RS15025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPE50_RS15035	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS15040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPE50_RS15060	COG1399	metal-binding, possibly nucleic acid-binding protein
HPE50_RS15065	COG0424	maF-like protein
HPE50_RS15070	COG0564	pseudouridine synthase activity
HPE50_RS15075	COG1530	ribonuclease E activity
HPE50_RS15090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPE50_RS15095	COG1256	bacterial-type flagellum assembly
HPE50_RS15100	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPE50_RS15100	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPE50_RS15105	COG1706	bacterial-type flagellum-dependent cell motility
HPE50_RS15115	COG4786	Flagellar basal body rod
HPE50_RS15120	COG4787	bacterial-type flagellum-dependent cell motility
HPE50_RS15125	COG1749	Flagellar hook protein flgE
HPE50_RS15130	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPE50_RS15135	COG1558	bacterial-type flagellum-dependent cell motility
HPE50_RS15140	COG1815	bacterial-type flagellum-dependent cell motility
HPE50_RS15145	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HPE50_RS15150	COG2747	anti-sigma28 factor FlgM
HPE50_RS15155	COG3418	PFAM FlgN family protein
HPE50_RS15160	COG0728	peptidoglycan biosynthetic process
HPE50_RS15165	COG0673	inositol 2-dehydrogenase activity
HPE50_RS15175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPE50_RS15185	COG2999	glutathione oxidoreductase activity
HPE50_RS15210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPE50_RS15220	COG3038	cytochrome b561
HPE50_RS15225	COG2353	YceI-like domain
HPE50_RS15235	COG1560	Kdo2-lipid A biosynthetic process
HPE50_RS15250	COG5645	(Lipo)protein
HPE50_RS15255	COG2943	transferase activity, transferring hexosyl groups
HPE50_RS15270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPE50_RS15275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPE50_RS15300	COG2197	response regulator
HPE50_RS15315	COG1462	curli production assembly transport component CsgG
HPE50_RS15325	COG3381	protein complex oligomerization
HPE50_RS15350	COG1702	phosphate starvation-inducible protein PhoH
HPE50_RS15370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPE50_RS15380	COG0506	proline dehydrogenase activity
HPE50_RS15380	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPE50_RS15380	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPE50_RS15385	COG1309	transcriptional regulator
HPE50_RS15420	COG2233	PERMEase
HPE50_RS15425	COG3729	General stress protein
HPE50_RS15460	COG3381	protein complex oligomerization
HPE50_RS15465	COG0243	molybdopterin cofactor binding
HPE50_RS15470	COG3005	denitrification pathway
HPE50_RS15475	COG0745	RESPONSE REGULATOR receiver
HPE50_RS15480	COG1879	ABC-type sugar transport system periplasmic component
HPE50_RS15485	COG2205	protein histidine kinase activity
HPE50_RS15485	COG2198	Histidine kinase
HPE50_RS15485	COG0784	Response regulator, receiver
HPE50_RS15490	COG0348	domain, Protein
HPE50_RS15510	COG1278	Cold shock
HPE50_RS15515	COG1278	Cold shock
HPE50_RS15530	COG1294	oxidase, subunit
HPE50_RS15535	COG1271	oxidase subunit
HPE50_RS15540	COG1773	rubredoxin
HPE50_RS15545	COG1999	signal sequence binding
HPE50_RS15550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPE50_RS15555	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HPE50_RS15560	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPE50_RS15565	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPE50_RS15575	COG0670	Belongs to the BI1 family
HPE50_RS15580	COG2920	part of a sulfur-relay system
HPE50_RS15585	COG1254	Belongs to the acylphosphatase family
HPE50_RS15600	COG1832	CoA-binding protein
HPE50_RS15615	COG0210	DNA helicase
HPE50_RS15620	COG3304	Inner membrane component domain
HPE50_RS15625	COG1289	transmembrane transporter activity
HPE50_RS15630	COG3070	regulator of competence-specific genes
HPE50_RS15650	COG1067	ATP-dependent peptidase activity
HPE50_RS15660	COG3130	regulation of translation
HPE50_RS15665	COG3009	Protein conserved in bacteria
HPE50_RS15670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPE50_RS15670	COG3008	intermembrane lipid transfer
HPE50_RS15675	COG2995	paraquat-inducible protein a
HPE50_RS15680	COG0488	(ABC) transporter
HPE50_RS15690	COG0633	Ferredoxin
HPE50_RS15690	COG3217	Mosc domain protein beta barrel domain protein
HPE50_RS15705	COG3121	Chaperone
HPE50_RS15710	COG3539	Fimbrial protein
HPE50_RS15715	COG3539	Fimbrial protein
HPE50_RS15720	COG3539	Fimbrial protein
HPE50_RS15725	COG3188	usher protein
HPE50_RS15740	COG0431	NADPH-dependent FMN reductase
HPE50_RS15745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPE50_RS15755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPE50_RS15760	COG1116	anion transmembrane transporter activity
HPE50_RS15765	COG0308	aminopeptidase N
HPE50_RS15780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPE50_RS15785	COG1448	Aminotransferase
HPE50_RS15790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPE50_RS15795	COG3108	Peptidase M15
HPE50_RS15800	COG2989	Protein conserved in bacteria
HPE50_RS15810	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPE50_RS15820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPE50_RS15825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPE50_RS15830	COG3173	Aminoglycoside phosphotransferase
HPE50_RS15845	COG3214	Protein conserved in bacteria
HPE50_RS15855	COG1132	(ABC) transporter
HPE50_RS15860	COG0658	competence protein
HPE50_RS15860	COG2333	competence protein COMEC
HPE50_RS15870	COG0539	negative regulation of cytoplasmic translation
HPE50_RS15880	COG0501	Belongs to the peptidase M48B family
HPE50_RS15885	COG3385	transposase activity
HPE50_RS15900	COG2323	membrane
HPE50_RS15905	COG1944	ATP diphosphatase activity
HPE50_RS15910	COG2116	formate transmembrane transporter activity
HPE50_RS15915	COG1882	Formate acetyltransferase
HPE50_RS15920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPE50_RS15925	COG0457	Tetratricopeptide repeat
HPE50_RS15925	COG3118	belongs to the thioredoxin family
HPE50_RS15950	COG2199	diguanylate cyclase activity
HPE50_RS15955	COG2200	EAL domain
HPE50_RS15970	COG1335	isochorismatase
HPE50_RS15975	COG3302	dmso reductase anchor subunit
HPE50_RS15980	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS15985	COG0243	molybdopterin cofactor binding
HPE50_RS15990	COG4974	Belongs to the 'phage' integrase family
HPE50_RS16090	COG4695	Portal protein
HPE50_RS16175	COG5301	cellulose 1,4-beta-cellobiosidase activity
HPE50_RS16175	COG5301	cellulose 1,4-beta-cellobiosidase activity
HPE50_RS16180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPE50_RS16235	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPE50_RS16245	COG1674	ftsk spoiiie
HPE50_RS16245	COG1178	ABC-type Fe3 transport system permease component
HPE50_RS16250	COG1522	sequence-specific DNA binding
HPE50_RS16255	COG0492	ferredoxin-NADP+ reductase activity
HPE50_RS16260	COG4988	ABC transporter
HPE50_RS16265	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPE50_RS16285	COG0542	response to heat
HPE50_RS16370	COG1278	Cold shock
HPE50_RS16375	COG1136	(ABC) transporter
HPE50_RS16375	COG0577	efflux transmembrane transporter activity
HPE50_RS16380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPE50_RS16385	COG2990	Protein conserved in bacteria
HPE50_RS16390	COG3593	DNA synthesis involved in DNA repair
HPE50_RS16395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPE50_RS16405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPE50_RS16410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPE50_RS16415	COG0625	glutathione transferase activity
HPE50_RS16430	COG2271	Major facilitator Superfamily
HPE50_RS16445	COG1346	cytolysis
HPE50_RS16455	COG2949	membrane
HPE50_RS16465	COG0493	'glutamate synthase
HPE50_RS16470	COG0167	dihydroorotate dehydrogenase activity
HPE50_RS16470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPE50_RS16475	COG4211	Belongs to the binding-protein-dependent transport system permease family
HPE50_RS16480	COG1129	ABC transporter
HPE50_RS16485	COG1879	ABC-type sugar transport system periplasmic component
HPE50_RS16490	COG1609	Transcriptional regulator
HPE50_RS16495	COG2311	Membrane
HPE50_RS16515	COG0833	amino acid
HPE50_RS16520	COG0583	DNA-binding transcription factor activity
HPE50_RS16525	COG2855	membrane
HPE50_RS16535	COG1522	sequence-specific DNA binding
HPE50_RS16535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS16540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPE50_RS16555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPE50_RS16560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPE50_RS16565	COG2313	pseudouridylate synthase activity
HPE50_RS16570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS16575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS16575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS16575	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPE50_RS16580	COG1105	Belongs to the carbohydrate kinase PfkB family
HPE50_RS16585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS16585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS16590	COG2814	Major facilitator Superfamily
HPE50_RS16605	COG0246	Mannitol dehydrogenase
HPE50_RS16610	COG0523	cobalamin synthesis protein
HPE50_RS16615	COG0671	phosphoesterase, PA-phosphatase related
HPE50_RS16620	COG0791	NLP P60 protein
HPE50_RS16625	COG2200	EAL domain
HPE50_RS16630	COG4166	transmembrane transport
HPE50_RS16635	COG4174	ABC transporter (Permease)
HPE50_RS16645	COG4172	Belongs to the ABC transporter superfamily
HPE50_RS16655	COG2814	Major facilitator Superfamily
HPE50_RS16660	COG1187	pseudouridine synthase activity
HPE50_RS16665	COG1061	Type III restriction enzyme res subunit
HPE50_RS16685	COG3083	sulfuric ester hydrolase activity
HPE50_RS16695	COG3385	transposase activity
HPE50_RS16700	COG3468	outer membrane autotransporter barrel domain protein
HPE50_RS16710	COG2197	response regulator
HPE50_RS16715	COG4235	cytochrome complex assembly
HPE50_RS16715	COG3088	subunit of a heme lyase
HPE50_RS16720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPE50_RS16725	COG1138	Cytochrome C-type biogenesis protein
HPE50_RS16735	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPE50_RS16740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPE50_RS16745	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPE50_RS16750	COG4133	protoheme IX ABC transporter activity
HPE50_RS16755	COG3005	denitrification pathway
HPE50_RS16760	COG3043	anaerobic respiration
HPE50_RS16765	COG0348	domain, Protein
HPE50_RS16770	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS16780	COG3062	negative regulation of establishment of protein localization
HPE50_RS16785	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPE50_RS16785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPE50_RS16805	COG4615	Cyclic peptide transporter
HPE50_RS16810	COG3145	DNA-N1-methyladenine dioxygenase activity
HPE50_RS16815	COG2169	Transcriptional regulator
HPE50_RS16815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPE50_RS16820	COG1477	protein flavinylation
HPE50_RS16825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPE50_RS16830	COG0642	Histidine kinase
HPE50_RS16830	COG2198	Histidine kinase
HPE50_RS16835	COG2197	response regulator
HPE50_RS16840	COG2205	protein histidine kinase activity
HPE50_RS16840	COG0784	Response regulator, receiver
HPE50_RS16860	COG2204	response regulator
HPE50_RS16865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPE50_RS16870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPE50_RS16875	COG2031	fatty acid transporter
HPE50_RS16880	COG0183	Belongs to the thiolase family
HPE50_RS16885	COG4676	Protein conserved in bacteria
HPE50_RS16890	COG5445	Predicted secreted protein (DUF2300)
HPE50_RS16895	COG2373	Large extracellular alpha-helical protein
HPE50_RS16900	COG3234	Protein of unknown function (DUF1175)
HPE50_RS16905	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HPE50_RS16910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPE50_RS16915	COG4948	Mandelate Racemase Muconate Lactonizing
HPE50_RS16925	COG1802	Transcriptional regulator
HPE50_RS16935	COG3468	outer membrane autotransporter barrel domain protein
HPE50_RS16940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPE50_RS16945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPE50_RS16950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPE50_RS16955	COG3642	lipopolysaccharide core region biosynthetic process
HPE50_RS16960	COG2814	Major facilitator Superfamily
HPE50_RS16965	COG0583	DNA-binding transcription factor activity
HPE50_RS16970	COG0584	glycerophosphoryl diester phosphodiesterase
HPE50_RS16975	COG2271	Major facilitator Superfamily
HPE50_RS16980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPE50_RS16990	COG0247	lactate metabolic process
HPE50_RS16995	COG5464	transposase or invertase
HPE50_RS17010	COG2271	Major facilitator Superfamily
HPE50_RS17020	COG1414	Transcriptional regulator
HPE50_RS17085	COG0318	PFAM AMP-dependent synthetase and ligase
HPE50_RS17095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPE50_RS17110	COG1169	isochorismate synthase
HPE50_RS17115	COG4575	ribosome binding
HPE50_RS17120	COG2153	protein acetylation
HPE50_RS17130	COG5160	protein modification by small protein removal
HPE50_RS17135	COG2234	aminopeptidase activity
HPE50_RS17150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPE50_RS17155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPE50_RS17165	COG0839	Belongs to the complex I subunit 6 family
HPE50_RS17180	COG1034	ATP synthesis coupled electron transport
HPE50_RS17185	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HPE50_RS17190	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HPE50_RS17210	COG0583	DNA-binding transcription factor activity
HPE50_RS17215	COG0436	Aminotransferase
HPE50_RS17225	COG0471	metal ion transport
HPE50_RS17225	COG0490	domain, Protein
HPE50_RS17230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPE50_RS17245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPE50_RS17250	COG0280	phosphate acetyltransferase
HPE50_RS17250	COG0857	belongs to the CobB CobQ family
HPE50_RS17255	COG1288	antiporter activity
HPE50_RS17260	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HPE50_RS17265	COG0622	Phosphoesterase
HPE50_RS17270	COG0625	glutathione transferase activity
HPE50_RS17275	COG0625	glutathione transferase activity
HPE50_RS17280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPE50_RS17285	COG1090	epimerase
HPE50_RS17290	COG1757	Na H antiporter
HPE50_RS17295	COG0626	cystathionine gamma-synthase activity
HPE50_RS17300	COG5464	transposase or invertase
HPE50_RS17305	COG4598	ABC transporter
HPE50_RS17310	COG4160	amino acid transport
HPE50_RS17315	COG4215	(ABC) transporter
HPE50_RS17320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPE50_RS17325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPE50_RS17330	COG0163	prenyltransferase activity
HPE50_RS17335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPE50_RS17340	COG1286	toxin biosynthetic process
HPE50_RS17345	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPE50_RS17350	COG0285	dihydrofolate synthase activity
HPE50_RS17360	COG0586	Pfam SNARE associated Golgi protein
HPE50_RS17370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPE50_RS17385	COG2814	Major facilitator Superfamily
HPE50_RS17390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPE50_RS17405	COG3101	peptidyl-lysine hydroxylation
HPE50_RS17410	COG0730	response to heat
HPE50_RS17425	COG2890	protein-(glutamine-N5) methyltransferase activity
HPE50_RS17450	COG3539	Fimbrial protein
HPE50_RS17455	COG3539	Fimbrial protein
HPE50_RS17460	COG3539	Fimbrial protein
HPE50_RS17465	COG3121	Chaperone
HPE50_RS17470	COG3188	usher protein
HPE50_RS17475	COG3539	Fimbrial protein
HPE50_RS17480	COG2062	phosphohistidine phosphatase, SixA
HPE50_RS17495	COG3691	Protein conserved in bacteria
HPE50_RS17500	COG2067	long-chain fatty acid transport protein
HPE50_RS17520	COG2853	Lipoprotein
HPE50_RS17525	COG2116	formate transmembrane transporter activity
HPE50_RS17535	COG0583	DNA-binding transcription factor activity
HPE50_RS17540	COG2610	gluconate transmembrane transporter activity
HPE50_RS17550	COG0477	Major facilitator Superfamily
HPE50_RS17555	COG1566	PFAM secretion protein HlyD family protein
HPE50_RS17560	COG2197	response regulator
HPE50_RS17565	COG2198	Histidine kinase
HPE50_RS17565	COG0784	Response regulator, receiver
HPE50_RS17565	COG2205	protein histidine kinase activity
HPE50_RS17565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPE50_RS17570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPE50_RS17575	COG0679	Auxin Efflux Carrier
HPE50_RS17580	COG0028	Belongs to the TPP enzyme family
HPE50_RS17605	COG1560	Kdo2-lipid A biosynthetic process
HPE50_RS17615	COG0436	Aminotransferase
HPE50_RS17620	COG3275	phosphorelay sensor kinase activity
HPE50_RS17625	COG3279	Response regulator of the LytR AlgR family
HPE50_RS17630	COG2207	Transcriptional regulator
HPE50_RS17635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS17635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPE50_RS17635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS17640	COG1363	Peptidase, m42
HPE50_RS17645	COG0006	proline dipeptidase activity
HPE50_RS17650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS17655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS17680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPE50_RS17685	COG3385	transposase activity
HPE50_RS17690	COG2199	diguanylate cyclase activity
HPE50_RS17690	COG2200	EAL domain
HPE50_RS17705	COG3415	Transposase
HPE50_RS17710	COG3415	Transposase
HPE50_RS17715	COG0675	Transposase, IS605 OrfB family
HPE50_RS17725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPE50_RS17745	COG0583	DNA-binding transcription factor activity
HPE50_RS17755	COG2211	Major facilitator Superfamily
HPE50_RS17760	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPE50_RS17770	COG0583	DNA-binding transcription factor activity
HPE50_RS17775	COG0385	Bile acid
HPE50_RS17780	COG3530	Putative quorum-sensing-regulated virulence factor
HPE50_RS17800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPE50_RS17805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS17810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPE50_RS17815	COG2190	(PTS) system
HPE50_RS17830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPE50_RS17835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPE50_RS17840	COG4208	sulfate ABC transporter
HPE50_RS17845	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPE50_RS17850	COG4150	thiosulfate binding
HPE50_RS17855	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS17870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS17870	COG1263	PTS System
HPE50_RS17875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPE50_RS17880	COG2837	iron assimilation
HPE50_RS17900	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPE50_RS17910	COG2207	Transcriptional regulator
HPE50_RS17915	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HPE50_RS17920	COG4816	utilization protein
HPE50_RS17930	COG4303	Ethanolamine ammonia lyase large subunit
HPE50_RS17935	COG4819	ethanolamine utilization protein
HPE50_RS17940	COG3192	ethanolamine utilization protein
HPE50_RS17945	COG1454	alcohol dehydrogenase
HPE50_RS17950	COG4820	ethanolamine utilization protein (EutJ)
HPE50_RS17955	COG1012	belongs to the aldehyde dehydrogenase family
HPE50_RS17960	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HPE50_RS17965	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HPE50_RS17970	COG0280	phosphate acetyltransferase
HPE50_RS17975	COG4812	Cobalamin adenosyltransferase
HPE50_RS17980	COG4766	ethanolamine catabolic process
HPE50_RS17985	COG4917	ethanolamine utilization protein
HPE50_RS17995	COG4810	utilization protein
HPE50_RS18000	COG0438	transferase activity, transferring glycosyl groups
HPE50_RS18005	COG0281	malic enzyme
HPE50_RS18005	COG0280	phosphate acetyltransferase
HPE50_RS18010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPE50_RS18015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPE50_RS18020	COG5342	invasion associated locus B
HPE50_RS18030	COG0493	'glutamate synthase
HPE50_RS18030	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPE50_RS18035	COG3850	Histidine kinase
HPE50_RS18040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPE50_RS18050	COG1393	Belongs to the ArsC family
HPE50_RS18065	COG0400	carboxylic ester hydrolase activity
HPE50_RS18075	COG2321	neutral zinc metallopeptidase
HPE50_RS18085	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPE50_RS18095	COG2716	regulation of RNA biosynthetic process
HPE50_RS18100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPE50_RS18105	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPE50_RS18110	COG0651	ATP synthesis coupled electron transport
HPE50_RS18115	COG0650	Formate hydrogenlyase subunit 4
HPE50_RS18120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPE50_RS18125	COG4237	Hydrogenase 4 membrane
HPE50_RS18130	COG0651	ATP synthesis coupled electron transport
HPE50_RS18135	COG3261	NADH dehydrogenase
HPE50_RS18135	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HPE50_RS18140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPE50_RS18145	COG3260	NADH ubiquinone oxidoreductase 20
HPE50_RS18155	COG3604	Transcriptional regulator
HPE50_RS18160	COG2116	formate transmembrane transporter activity
HPE50_RS18165	COG0628	permease
HPE50_RS18170	COG4783	chaperone-mediated protein folding
HPE50_RS18175	COG1393	Belongs to the ArsC family
HPE50_RS18185	COG2233	PERMEase
HPE50_RS18200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPE50_RS18205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPE50_RS18210	COG0248	Ppx GppA phosphatase
HPE50_RS18215	COG2200	EAL domain
HPE50_RS18230	COG3133	Outer membrane lipoprotein
HPE50_RS18245	COG0517	IMP dehydrogenase activity
HPE50_RS18245	COG0516	GMP reductase activity
HPE50_RS18270	COG1645	bacterial-type flagellum-dependent swarming motility
HPE50_RS18285	COG2976	Protein conserved in bacteria
HPE50_RS18315	COG4953	penicillin-binding protein 1C
HPE50_RS18320	COG2373	Large extracellular alpha-helical protein
HPE50_RS18325	COG2897	thiosulfate sulfurtransferase activity
HPE50_RS18345	COG2975	iron-sulfur cluster assembly
HPE50_RS18350	COG0633	Ferredoxin
HPE50_RS18370	COG0822	iron-sulfur transferase activity
HPE50_RS18390	COG0483	inositol monophosphate 1-phosphatase activity
HPE50_RS18395	COG1073	alpha beta
HPE50_RS18400	COG3711	transcriptional antiterminator
HPE50_RS18405	COG2814	Major facilitator Superfamily
HPE50_RS18410	COG0583	DNA-binding transcription factor activity
HPE50_RS18415	COG4638	Rieske (2fe-2S)
HPE50_RS18445	COG2259	Doxx family
HPE50_RS18450	COG2017	converts alpha-aldose to the beta-anomer
HPE50_RS18455	COG1063	alcohol dehydrogenase
HPE50_RS18460	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPE50_RS18465	COG1129	ABC transporter
HPE50_RS18470	COG1879	ABC-type sugar transport system periplasmic component
HPE50_RS18475	COG0457	Tetratricopeptide repeat
HPE50_RS18480	COG1940	carbohydrate kinase activity
HPE50_RS18490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPE50_RS18490	COG1017	nitric oxide dioxygenase activity
HPE50_RS18495	COG0347	Belongs to the P(II) protein family
HPE50_RS18500	COG2204	response regulator
HPE50_RS18505	COG3170	Tfp pilus assembly protein FimV
HPE50_RS18510	COG2205	protein histidine kinase activity
HPE50_RS18515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPE50_RS18515	COG0047	phosphoribosylformylglycinamidine synthase activity
HPE50_RS18525	COG0590	tRNA wobble adenosine to inosine editing
HPE50_RS18530	COG0560	Phosphoserine phosphatase
HPE50_RS18535	COG1737	Transcriptional regulator
HPE50_RS18540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPE50_RS18555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPE50_RS18575	COG0681	Belongs to the peptidase S26 family
HPE50_RS18585	COG3086	response to oxidative stress
HPE50_RS18590	COG3026	antisigma factor binding
HPE50_RS18595	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HPE50_RS18600	COG1595	DNA-templated transcription, initiation
HPE50_RS18610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPE50_RS18620	COG0513	Belongs to the DEAD box helicase family
HPE50_RS18625	COG0583	DNA-binding transcription factor activity
HPE50_RS18645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPE50_RS18650	COG3118	belongs to the thioredoxin family
HPE50_RS18660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPE50_RS18660	COG1042	CoA-binding domain protein
HPE50_RS18660	COG0045	succinate-CoA ligase (ADP-forming) activity
HPE50_RS18665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPE50_RS18670	COG5544	Lipoprotein
HPE50_RS18675	COG0477	Major facilitator Superfamily
HPE50_RS18700	COG0542	response to heat
HPE50_RS18710	COG0564	pseudouridine synthase activity
HPE50_RS18715	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPE50_RS18720	COG3385	transposase activity
HPE50_RS18725	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPE50_RS18735	COG0602	queuosine metabolic process
HPE50_RS18740	COG1070	Carbohydrate kinase
HPE50_RS18745	COG2223	nitrite transmembrane transporter activity
HPE50_RS18750	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS18755	COG0277	FAD linked oxidase domain protein
HPE50_RS18760	COG0477	Major facilitator Superfamily
HPE50_RS18765	COG2086	electron transfer activity
HPE50_RS18770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPE50_RS18775	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPE50_RS18780	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HPE50_RS18785	COG0644	oxidoreductase
HPE50_RS18790	COG0720	synthase
HPE50_RS18815	COG1203	CRISPR-associated helicase, Cas3
HPE50_RS18830	COG1857	crispr-associated protein
HPE50_RS18845	COG1518	maintenance of DNA repeat elements
HPE50_RS18850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPE50_RS18855	COG2234	aminopeptidase activity
HPE50_RS18910	COG4942	peptidase
HPE50_RS18910	COG1388	LysM domain
HPE50_RS18915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPE50_RS18925	COG0163	prenyltransferase activity
HPE50_RS18930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPE50_RS18940	COG2610	gluconate transmembrane transporter activity
HPE50_RS18945	COG3622	Belongs to the hyi family
HPE50_RS18950	COG0235	Class ii aldolase
HPE50_RS18955	COG3395	kinase activity
HPE50_RS18960	COG2084	Dehydrogenase
HPE50_RS18965	COG1349	DNA-binding transcription factor activity
HPE50_RS18970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPE50_RS18995	COG3604	Transcriptional regulator
HPE50_RS19000	COG0309	Hydrogenase expression formation protein (HypE)
HPE50_RS19005	COG0409	Hydrogenase expression formation protein
HPE50_RS19010	COG0298	carbon dioxide binding
HPE50_RS19015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPE50_RS19020	COG0375	protein maturation
HPE50_RS19030	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPE50_RS19035	COG0651	ATP synthesis coupled electron transport
HPE50_RS19040	COG0650	Formate hydrogenlyase subunit 4
HPE50_RS19045	COG3261	NADH dehydrogenase
HPE50_RS19045	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HPE50_RS19050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPE50_RS19055	COG3260	NADH ubiquinone oxidoreductase 20
HPE50_RS19065	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPE50_RS19075	COG2723	6-phospho-beta-galactosidase activity
HPE50_RS19080	COG1263	PTS System
HPE50_RS19080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS19085	COG1609	Transcriptional regulator
HPE50_RS19090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPE50_RS19095	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPE50_RS19115	COG0517	IMP dehydrogenase activity
HPE50_RS19115	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPE50_RS19120	COG1349	DNA-binding transcription factor activity
HPE50_RS19125	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS19130	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS19140	COG3732	PTS system glucitol sorbitol-specific
HPE50_RS19145	COG3730	PTS system glucitol sorbitol-specific
HPE50_RS19150	COG2951	lytic endotransglycosylase activity
HPE50_RS19155	COG1546	Belongs to the CinA family
HPE50_RS19175	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPE50_RS19205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPE50_RS19210	COG1238	metal cluster binding
HPE50_RS19225	COG2814	Major facilitator Superfamily
HPE50_RS19230	COG1566	PFAM secretion protein HlyD family protein
HPE50_RS19235	COG1846	Transcriptional regulator
HPE50_RS19245	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPE50_RS19250	COG2814	Major facilitator Superfamily
HPE50_RS19255	COG2113	Glycine betaine
HPE50_RS19260	COG4176	ABC-type proline glycine betaine transport system permease component
HPE50_RS19265	COG4175	Glycine betaine
HPE50_RS19270	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPE50_RS19275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPE50_RS19285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPE50_RS19290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPE50_RS19295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPE50_RS19300	COG4575	ribosome binding
HPE50_RS19315	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPE50_RS19320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPE50_RS19325	COG0640	Transcriptional regulator
HPE50_RS19330	COG0401	homolog of Blt101
HPE50_RS19335	COG1652	LysM domain
HPE50_RS19340	COG1802	Transcriptional regulator
HPE50_RS19345	COG1113	amino acid transport
HPE50_RS19350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPE50_RS19355	COG1012	belongs to the aldehyde dehydrogenase family
HPE50_RS19360	COG0579	oxidoreductase
HPE50_RS19395	COG3468	outer membrane autotransporter barrel domain protein
HPE50_RS19450	COG0582	viral genome integration into host DNA
HPE50_RS19460	COG4974	Belongs to the 'phage' integrase family
HPE50_RS19495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPE50_RS19545	COG4695	Portal protein
HPE50_RS19635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPE50_RS19680	COG1192	Involved in chromosome partitioning
HPE50_RS19695	COG2867	negative regulation of translational initiation
HPE50_RS19705	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPE50_RS19710	COG0497	DNA recombination
HPE50_RS19730	COG4536	flavin adenine dinucleotide binding
HPE50_RS19735	COG4137	Cytochrome C assembly protein
HPE50_RS19740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPE50_RS19765	COG2885	chlorophyll binding
HPE50_RS19770	COG2199	diguanylate cyclase activity
HPE50_RS19785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPE50_RS19790	COG1605	Chorismate mutase
HPE50_RS19790	COG0287	Prephenate dehydrogenase
HPE50_RS19795	COG0077	Prephenate dehydratase
HPE50_RS19795	COG1605	Chorismate mutase
HPE50_RS19805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPE50_RS19810	COG3385	transposase activity
HPE50_RS19825	COG3956	TIGRFAM MazG family protein
HPE50_RS19830	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPE50_RS19835	COG2336	PFAM SpoVT AbrB
HPE50_RS19840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPE50_RS19850	COG2205	protein histidine kinase activity
HPE50_RS19850	COG4999	Histidine kinase
HPE50_RS19850	COG3850	Histidine kinase
HPE50_RS19850	COG3437	response regulator, receiver
HPE50_RS19855	COG4948	Mandelate Racemase Muconate Lactonizing
HPE50_RS19860	COG4948	Mandelate Racemase Muconate Lactonizing
HPE50_RS19865	COG2271	Major facilitator Superfamily
HPE50_RS19870	COG0716	FMN binding
HPE50_RS19875	COG0564	pseudouridine synthase activity
HPE50_RS19880	COG3098	single-species biofilm formation
HPE50_RS19895	COG1611	Belongs to the LOG family
HPE50_RS19900	COG0814	amino acid
HPE50_RS19905	COG1760	l-serine dehydratase
HPE50_RS19915	COG1454	alcohol dehydrogenase
HPE50_RS19920	COG0235	Class ii aldolase
HPE50_RS19925	COG0738	Major facilitator superfamily
HPE50_RS19935	COG1070	Carbohydrate kinase
HPE50_RS19945	COG1349	DNA-binding transcription factor activity
HPE50_RS19955	COG2363	Small membrane protein
HPE50_RS19960	COG0583	DNA-binding transcription factor activity
HPE50_RS19970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPE50_RS19975	COG2166	iron-sulfur cluster assembly
HPE50_RS19980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPE50_RS19985	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPE50_RS20015	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPE50_RS20020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS20020	COG1263	PTS System
HPE50_RS20025	COG3711	transcriptional antiterminator
HPE50_RS20030	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPE50_RS20035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPE50_RS20035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPE50_RS20040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPE50_RS20045	COG1074	ATP-dependent DNA helicase activity
HPE50_RS20050	COG1025	Belongs to the peptidase M16 family
HPE50_RS20055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPE50_RS20060	COG4967	type IV pilus modification protein PilV
HPE50_RS20070	COG4795	General secretion pathway protein
HPE50_RS20075	COG2165	general secretion pathway protein
HPE50_RS20105	COG0861	Integral membrane protein TerC family
HPE50_RS20115	COG0667	Aldo Keto reductase
HPE50_RS20130	COG1609	Transcriptional regulator
HPE50_RS20140	COG0583	DNA-binding transcription factor activity
HPE50_RS20145	COG1794	racemase activity, acting on amino acids and derivatives
HPE50_RS20150	COG2814	Major facilitator Superfamily
HPE50_RS20155	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS20165	COG0183	Belongs to the thiolase family
HPE50_RS20170	COG0814	amino acid
HPE50_RS20175	COG2771	luxR family
HPE50_RS20180	COG3710	Transcriptional regulator
HPE50_RS20205	COG0457	Tetratricopeptide repeat
HPE50_RS20210	COG3710	Transcriptional regulator
HPE50_RS20210	COG0457	Tetratricopeptide repeat
HPE50_RS20220	COG0741	lytic transglycosylase activity
HPE50_RS20225	COG2197	response regulator
HPE50_RS20265	COG2080	2 iron, 2 sulfur cluster binding
HPE50_RS20270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HPE50_RS20275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPE50_RS20280	COG4942	peptidase
HPE50_RS20320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPE50_RS20330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPE50_RS20335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPE50_RS20340	COG4974	Belongs to the 'phage' integrase family
HPE50_RS20345	COG0716	FMN binding
HPE50_RS20355	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPE50_RS20365	COG1272	protein, Hemolysin III
HPE50_RS20375	COG2723	6-phospho-beta-galactosidase activity
HPE50_RS20400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPE50_RS20405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPE50_RS20410	COG0006	proline dipeptidase activity
HPE50_RS20430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPE50_RS20440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPE50_RS20455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPE50_RS20465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPE50_RS20475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPE50_RS20475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPE50_RS20480	COG1703	isobutyryl-CoA mutase activity
HPE50_RS20485	COG1024	Enoyl-CoA hydratase
HPE50_RS20490	COG0427	acetyl-CoA hydrolase
HPE50_RS20500	COG2968	Membrane
HPE50_RS20520	COG0668	transmembrane transport
HPE50_RS20525	COG0191	fructose-bisphosphate aldolase activity
HPE50_RS20555	COG1122	ATPase activity
HPE50_RS20560	COG1122	ATPase activity
HPE50_RS20565	COG1072	(Pantothenic acid kinase))
HPE50_RS20575	COG1494	fructose-1,6-bisphosphatase
HPE50_RS20580	COG1063	alcohol dehydrogenase
HPE50_RS20585	COG2213	PTS system mannitol-specific
HPE50_RS20600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS20605	COG0330	HflC and HflK could
HPE50_RS20610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPE50_RS20615	COG0501	Belongs to the peptidase M48B family
HPE50_RS20630	COG3716	PTS system mannose fructose sorbose family IID component
HPE50_RS20635	COG3715	PTS system
HPE50_RS20640	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS20640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS20665	COG1166	arginine decarboxylase activity
HPE50_RS20690	COG2814	Major facilitator Superfamily
HPE50_RS20700	COG2356	endonuclease I
HPE50_RS20705	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPE50_RS20710	COG0189	ligase activity
HPE50_RS20725	COG2805	Type II/IV secretion system protein
HPE50_RS20730	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPE50_RS20735	COG0762	integral membrane protein
HPE50_RS20745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPE50_RS20750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPE50_RS20755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPE50_RS20760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPE50_RS20775	COG0252	asparaginase activity
HPE50_RS20785	COG3171	Protein conserved in bacteria
HPE50_RS20795	COG1194	a g-specific adenine glycosylase
HPE50_RS20810	COG2211	Major facilitator Superfamily
HPE50_RS20815	COG1982	Orn Lys Arg decarboxylase major
HPE50_RS20820	COG1811	Na channel or pump
HPE50_RS20830	COG0582	viral genome integration into host DNA
HPE50_RS20850	COG3436	PFAM IS66 Orf2 family protein
HPE50_RS20855	COG4372	Transposase
HPE50_RS21020	COG4771	TonB-dependent receptor
HPE50_RS21075	COG3468	outer membrane autotransporter barrel domain protein
HPE50_RS21140	COG4372	Transposase
HPE50_RS21145	COG3436	PFAM IS66 Orf2 family protein
HPE50_RS21205	COG3468	outer membrane autotransporter barrel domain protein
HPE50_RS21210	COG2020	methyltransferase activity
HPE50_RS21240	COG2003	Belongs to the UPF0758 family
HPE50_RS21350	COG2089	acid synthase
HPE50_RS21370	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPE50_RS21385	COG4795	General secretion pathway protein
HPE50_RS21400	COG2165	general secretion pathway protein
HPE50_RS21405	COG1459	type II secretion system
HPE50_RS21410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPE50_RS21430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPE50_RS21435	COG3064	Membrane
HPE50_RS21440	COG1620	l-lactate permease
HPE50_RS21445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPE50_RS21450	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HPE50_RS21455	COG0247	lactate metabolic process
HPE50_RS21460	COG0277	FAD linked oxidase domain protein
HPE50_RS21465	COG0277	FAD linked oxidase domain protein
HPE50_RS21470	COG2186	Transcriptional regulator
HPE50_RS21475	COG0456	acetyltransferase
HPE50_RS21485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPE50_RS21490	COG0306	phosphate transporter
HPE50_RS21495	COG0754	glutathionylspermidine amidase activity
HPE50_RS21500	COG0625	glutathione transferase activity
HPE50_RS21505	COG0298	carbon dioxide binding
HPE50_RS21510	COG0375	protein maturation
HPE50_RS21515	COG1773	rubredoxin
HPE50_RS21520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPE50_RS21525	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPE50_RS21530	COG5557	Pfam Polysulphide reductase, NrfD
HPE50_RS21535	COG0437	4 iron, 4 sulfur cluster binding
HPE50_RS21540	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPE50_RS21555	COG0667	Aldo Keto reductase
HPE50_RS21565	COG1028	Short-chain dehydrogenase reductase Sdr
HPE50_RS21570	COG0848	biopolymer transport protein
HPE50_RS21575	COG0811	peptide transport
HPE50_RS21580	COG0626	cystathionine gamma-synthase activity
HPE50_RS21585	COG0586	Pfam SNARE associated Golgi protein
HPE50_RS21590	COG2207	Transcriptional regulator
HPE50_RS21595	COG1979	alcohol dehydrogenase
HPE50_RS21600	COG0656	L-ascorbic acid biosynthetic process
HPE50_RS21610	COG4238	major outer membrane lipoprotein
HPE50_RS21615	COG1032	radical SAM domain protein
HPE50_RS21620	COG2186	Transcriptional regulator
HPE50_RS21625	COG0246	Mannitol dehydrogenase
HPE50_RS21630	COG1063	alcohol dehydrogenase
HPE50_RS21635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPE50_RS21650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPE50_RS21655	COG0204	Acyl-transferase
HPE50_RS21660	COG2132	Multicopper oxidase
HPE50_RS21675	COG4166	transmembrane transport
HPE50_RS21680	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPE50_RS21685	COG3111	PFAM Bacterial OB fold (BOF) protein
HPE50_RS21690	COG0745	RESPONSE REGULATOR receiver
HPE50_RS21695	COG0642	Histidine kinase
HPE50_RS21700	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPE50_RS21705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPE50_RS21710	COG1737	Transcriptional regulator
HPE50_RS21720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPE50_RS21725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPE50_RS21730	COG1120	ATPase activity
HPE50_RS21735	COG4774	siderophore transport
HPE50_RS21740	COG0187	DNA topoisomerase II activity
HPE50_RS21745	COG3150	esterase
HPE50_RS21750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPE50_RS21755	COG3151	Protein conserved in bacteria
HPE50_RS21760	COG0494	nUDIX hydrolase
HPE50_RS21765	COG1538	Outer membrane efflux protein
HPE50_RS21775	COG0754	glutathionylspermidine amidase activity
HPE50_RS21785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPE50_RS21795	COG3384	dioxygenase
HPE50_RS21820	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPE50_RS21825	COG2268	Band 7 protein
HPE50_RS21845	COG3025	triphosphatase activity
HPE50_RS21850	COG4991	sh3 domain protein
HPE50_RS21865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPE50_RS21880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HPE50_RS21885	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPE50_RS21900	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPE50_RS21905	COG0358	DNA primase activity
HPE50_RS21910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPE50_RS21930	COG2375	cellular response to nickel ion
HPE50_RS21935	COG1695	Transcriptional regulator
HPE50_RS21940	COG0840	transmembrane signaling receptor activity
HPE50_RS21950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPE50_RS21955	COG1609	Transcriptional regulator
HPE50_RS21960	COG3250	beta-galactosidase activity
HPE50_RS21965	COG2731	YhcH YjgK YiaL family protein
HPE50_RS21970	COG0531	amino acid
HPE50_RS21990	COG3408	Glycogen debranching enzyme
HPE50_RS21990	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HPE50_RS21995	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPE50_RS21995	COG1902	pentaerythritol trinitrate reductase activity
HPE50_RS22000	COG5499	transcription regulator containing HTH domain
HPE50_RS22015	COG1451	nucleotide metabolic process
HPE50_RS22020	COG2949	membrane
HPE50_RS22025	COG0673	inositol 2-dehydrogenase activity
HPE50_RS22030	COG0861	Integral membrane protein TerC family
HPE50_RS22035	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPE50_RS22045	COG2721	sulfolactate sulfo-lyase activity
HPE50_RS22055	COG2271	Major facilitator Superfamily
HPE50_RS22080	COG2186	Transcriptional regulator
HPE50_RS22085	COG0586	Pfam SNARE associated Golgi protein
HPE50_RS22095	COG1422	Protein of unknown function (DUF1090)
HPE50_RS22100	COG4575	ribosome binding
HPE50_RS22105	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HPE50_RS22115	COG2259	Doxx family
HPE50_RS22120	COG0435	Glutathione S-transferase
HPE50_RS22125	COG3152	Membrane
HPE50_RS22130	COG3152	Membrane
HPE50_RS22135	COG0583	DNA-binding transcription factor activity
HPE50_RS22140	COG1741	Belongs to the pirin family
HPE50_RS22155	COG0814	amino acid
HPE50_RS22160	COG1760	l-serine dehydratase
HPE50_RS22165	COG0251	oxidation-reduction process
HPE50_RS22170	COG1882	Formate acetyltransferase
HPE50_RS22175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPE50_RS22185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPE50_RS22190	COG0583	DNA-binding transcription factor activity
HPE50_RS22215	COG1929	Belongs to the glycerate kinase type-1 family
HPE50_RS22220	COG2084	Dehydrogenase
HPE50_RS22230	COG2271	Major facilitator Superfamily
HPE50_RS22245	COG2002	toxin-antitoxin pair type II binding
HPE50_RS22255	COG1349	DNA-binding transcription factor activity
HPE50_RS22265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPE50_RS22275	COG3716	PTS system mannose fructose sorbose family IID component
HPE50_RS22280	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS22285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPE50_RS22290	COG2222	sugar isomerase
HPE50_RS22310	COG3715	PTS system
HPE50_RS22315	COG3716	PTS system mannose fructose sorbose family IID component
HPE50_RS22320	COG0363	glucosamine-6-phosphate deaminase activity
HPE50_RS22325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPE50_RS22345	COG2823	Periplasmic or secreted lipoprotein
HPE50_RS22350	COG0701	Predicted permease
HPE50_RS22355	COG0702	epimerase
HPE50_RS22360	COG0693	protein deglycase activity
HPE50_RS22375	COG3153	acetyltransferase
HPE50_RS22380	COG3154	lipid carrier protein
HPE50_RS22385	COG0826	peptidase U32
HPE50_RS22390	COG0826	peptidase U32
HPE50_RS22395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPE50_RS22400	COG0814	amino acid
HPE50_RS22405	COG0513	Belongs to the DEAD box helicase family
HPE50_RS22445	COG0195	Participates in both transcription termination and antitermination
HPE50_RS22465	COG2194	sulfuric ester hydrolase activity
HPE50_RS22475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPE50_RS22485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPE50_RS22490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPE50_RS22500	COG1534	Rna-binding protein
HPE50_RS22505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPE50_RS22510	COG2027	D-alanyl-D-alanine carboxypeptidase
HPE50_RS22520	COG0697	spore germination
HPE50_RS22535	COG0142	geranyltranstransferase activity
HPE50_RS22540	COG3423	Transcriptional regulator
HPE50_RS22550	COG5007	Belongs to the BolA IbaG family
HPE50_RS22555	COG3113	response to antibiotic
HPE50_RS22560	COG2854	intermembrane phospholipid transfer
HPE50_RS22565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPE50_RS22570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPE50_RS22575	COG1127	ABC transporter
HPE50_RS22580	COG0530	calcium, potassium:sodium antiporter activity
HPE50_RS22585	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPE50_RS22585	COG0517	IMP dehydrogenase activity
HPE50_RS22590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPE50_RS22595	COG3117	lipopolysaccharide transmembrane transporter activity
HPE50_RS22600	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPE50_RS22605	COG1137	ATPase activity
HPE50_RS22610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPE50_RS22615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPE50_RS22630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS22635	COG0515	serine threonine protein kinase
HPE50_RS22645	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPE50_RS22650	COG5002	protein histidine kinase activity
HPE50_RS22650	COG2198	Histidine kinase
HPE50_RS22650	COG0784	Response regulator, receiver
HPE50_RS22655	COG1242	4 iron, 4 sulfur cluster binding
HPE50_RS22660	COG0070	glutamate synthase
HPE50_RS22660	COG0069	glutamate synthase activity
HPE50_RS22660	COG0067	glutamate synthase
HPE50_RS22665	COG0493	'glutamate synthase
HPE50_RS22675	COG2731	YhcH YjgK YiaL family protein
HPE50_RS22720	COG2969	positive regulation of protein catabolic process
HPE50_RS22725	COG0625	glutathione transferase activity
HPE50_RS22740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPE50_RS22745	COG3105	Protein conserved in bacteria
HPE50_RS22750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPE50_RS22755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPE50_RS22775	COG2732	(Barnase) inhibitor
HPE50_RS22795	COG0583	DNA-binding transcription factor activity
HPE50_RS22800	COG0312	modulator of DNA gyrase
HPE50_RS22805	COG3164	Protein of unknown function
HPE50_RS22810	COG1530	ribonuclease E activity
HPE50_RS22820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPE50_RS22825	COG1792	Involved in formation and maintenance of cell shape
HPE50_RS22830	COG1077	Cell shape determining protein MreB Mrl
HPE50_RS22835	COG2199	diguanylate cyclase activity
HPE50_RS22835	COG2200	EAL domain
HPE50_RS22840	COG0604	alcohol dehydrogenase
HPE50_RS22850	COG0511	ligase activity, forming carbon-carbon bonds
HPE50_RS22855	COG0439	Biotin carboxylase
HPE50_RS22865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS22870	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPE50_RS22875	COG1129	ABC transporter
HPE50_RS22880	COG1879	ABC-type sugar transport system periplasmic component
HPE50_RS22890	COG1349	DNA-binding transcription factor activity
HPE50_RS22895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS22900	COG3924	membrane
HPE50_RS22905	COG4145	pantothenate transmembrane transporter activity
HPE50_RS22915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPE50_RS22925	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HPE50_RS22935	COG1309	transcriptional regulator
HPE50_RS22940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPE50_RS22960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPE50_RS22965	COG4597	amino acid ABC transporter
HPE50_RS22970	COG0765	amino acid transport
HPE50_RS22975	COG1126	abc transporter atp-binding protein
HPE50_RS23015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPE50_RS23035	COG0551	DNA topoisomerase type I activity
HPE50_RS23045	COG0758	DNA mediated transformation
HPE50_RS23065	COG0569	domain protein
HPE50_RS23075	COG3036	rescue of stalled ribosome
HPE50_RS23080	COG0789	Transcriptional regulator
HPE50_RS23120	COG0201	protein transport
HPE50_RS23210	COG0089	rRNA binding
HPE50_RS23280	COG2964	Protein conserved in bacteria
HPE50_RS23285	COG0545	Peptidyl-prolyl cis-trans isomerase
HPE50_RS23295	COG1047	Peptidyl-prolyl cis-trans
HPE50_RS23300	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HPE50_RS23315	COG0488	(ABC) transporter
HPE50_RS23320	COG0429	hydrolase of the alpha beta-hydrolase fold
HPE50_RS23330	COG3954	Phosphoribulokinase
HPE50_RS23335	COG1765	OsmC-like protein
HPE50_RS23340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPE50_RS23345	COG1289	transmembrane transporter activity
HPE50_RS23350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPE50_RS23355	COG0512	Glutamine amidotransferase of anthranilate synthase
HPE50_RS23360	COG2184	nucleotidyltransferase activity
HPE50_RS23370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPE50_RS23380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPE50_RS23385	COG2146	nitrite reductase [NAD(P)H] activity
HPE50_RS23390	COG2116	formate transmembrane transporter activity
HPE50_RS23405	COG0626	cystathionine gamma-synthase activity
HPE50_RS23420	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HPE50_RS23425	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPE50_RS23430	COG3457	Alanine racemase
HPE50_RS23440	COG2188	Transcriptional regulator
HPE50_RS23445	COG0180	Tryptophanyl-tRNA synthetase
HPE50_RS23455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPE50_RS23460	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPE50_RS23465	COG3266	domain, Protein
HPE50_RS23480	COG4796	Type ii and iii secretion system protein
HPE50_RS23495	COG3166	PFAM Fimbrial assembly family protein
HPE50_RS23500	COG4972	Pilus assembly protein
HPE50_RS23505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPE50_RS23510	COG0494	nUDIX hydrolase
HPE50_RS23520	COG1011	Hydrolase
HPE50_RS23525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPE50_RS23535	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPE50_RS23555	COG2205	protein histidine kinase activity
HPE50_RS23560	COG0745	RESPONSE REGULATOR receiver
HPE50_RS23565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPE50_RS23570	COG2183	response to ionizing radiation
HPE50_RS23575	COG1918	ferrous iron import across plasma membrane
HPE50_RS23580	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPE50_RS23590	COG5464	transposase or invertase
HPE50_RS23610	COG2610	gluconate transmembrane transporter activity
HPE50_RS23615	COG1640	4-alpha-glucanotransferase
HPE50_RS23620	COG0058	SHG alpha-glucan phosphorylase activity
HPE50_RS23635	COG1690	Belongs to the RtcB family
HPE50_RS23640	COG4650	regulator
HPE50_RS23645	COG1349	DNA-binding transcription factor activity
HPE50_RS23660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPE50_RS23675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPE50_RS23680	COG0058	SHG alpha-glucan phosphorylase activity
HPE50_RS23700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPE50_RS23705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPE50_RS23710	COG2095	MarC family integral membrane protein
HPE50_RS23720	COG0514	ATP-dependent DNA helicase (RecQ)
HPE50_RS23725	COG2610	gluconate transmembrane transporter activity
HPE50_RS23730	COG3265	gluconokinase activity
HPE50_RS23735	COG1609	Transcriptional regulator
HPE50_RS23740	COG1741	Belongs to the pirin family
HPE50_RS23745	COG0673	inositol 2-dehydrogenase activity
HPE50_RS23750	COG1247	-acetyltransferase
HPE50_RS23755	COG3157	Type VI secretion system effector, Hcp
HPE50_RS23775	COG0405	Gamma-glutamyltransferase
HPE50_RS23785	COG0584	glycerophosphoryl diester phosphodiesterase
HPE50_RS23800	COG1175	transmembrane transport
HPE50_RS23815	COG0410	ABC transporter
HPE50_RS23820	COG0411	ABC transporter
HPE50_RS23825	COG4177	L-phenylalanine transmembrane transporter activity
HPE50_RS23830	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPE50_RS23835	COG0683	leucine binding
HPE50_RS23840	COG0456	acetyltransferase
HPE50_RS23845	COG0683	leucine binding
HPE50_RS23850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPE50_RS23855	COG2177	Part of the ABC transporter FtsEX involved in
HPE50_RS23860	COG2884	Cell division ATP-binding protein ftsE
HPE50_RS23865	COG0552	protein localization to endoplasmic reticulum
HPE50_RS23870	COG0742	ribosomal rna small subunit methyltransferase
HPE50_RS23875	COG3776	membrane
HPE50_RS23885	COG3714	YhhN family
HPE50_RS23900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPE50_RS23910	COG0477	Major facilitator Superfamily
HPE50_RS23915	COG0628	permease
HPE50_RS23920	COG2091	lysine biosynthetic process via aminoadipic acid
HPE50_RS23925	COG0747	negative chemotaxis
HPE50_RS23930	COG0601	transmembrane transport
HPE50_RS23935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPE50_RS23955	COG2188	Transcriptional regulator
HPE50_RS23965	COG3414	Phosphotransferase system galactitol-specific IIB component
HPE50_RS23970	COG3775	system Galactitol-specific IIC component
HPE50_RS23985	COG0191	fructose-bisphosphate aldolase activity
HPE50_RS24000	COG0842	Transport permease protein
HPE50_RS24005	COG1129	ABC transporter
HPE50_RS24005	COG0842	Transport permease protein
HPE50_RS24010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPE50_RS24030	COG2081	HI0933 family
HPE50_RS24035	COG0306	phosphate transporter
HPE50_RS24045	COG0589	response to stress
HPE50_RS24050	COG3104	oligopeptide transport
HPE50_RS24060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS24060	COG2213	PTS system mannitol-specific
HPE50_RS24070	COG1349	DNA-binding transcription factor activity
HPE50_RS24075	COG0246	Mannitol dehydrogenase
HPE50_RS24080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS24080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS24085	COG0371	Dehydrogenase
HPE50_RS24090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPE50_RS24095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPE50_RS24100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPE50_RS24110	COG0339	signal peptide processing
HPE50_RS24115	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPE50_RS24120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPE50_RS24130	COG0640	Transcriptional regulator
HPE50_RS24135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPE50_RS24140	COG1393	Belongs to the ArsC family
HPE50_RS24170	COG3065	identical protein binding
HPE50_RS24175	COG2197	response regulator
HPE50_RS24180	COG3720	iron ion transport
HPE50_RS24185	COG4771	TonB-dependent receptor
HPE50_RS24200	COG3721	Heme iron utilization protein
HPE50_RS24210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPE50_RS24220	COG1285	pathogenesis
HPE50_RS24235	COG3247	response to pH
HPE50_RS24240	COG2771	luxR family
HPE50_RS24250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPE50_RS24255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPE50_RS24260	COG2207	Transcriptional regulator
HPE50_RS24270	COG0076	glutamate decarboxylase activity
HPE50_RS24275	COG1858	cytochrome C peroxidase
HPE50_RS24285	COG2197	response regulator
HPE50_RS24295	COG0583	DNA-binding transcription factor activity
HPE50_RS24300	COG1295	ribonuclease BN
HPE50_RS24305	COG0477	Major facilitator Superfamily
HPE50_RS24310	COG2982	Protein involved in outer membrane biogenesis
HPE50_RS24315	COG2200	EAL domain
HPE50_RS24320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPE50_RS24325	COG0612	Peptidase, M16
HPE50_RS24335	COG2200	EAL domain
HPE50_RS24335	COG2199	diguanylate cyclase activity
HPE50_RS24340	COG0457	Tetratricopeptide repeat
HPE50_RS24340	COG3118	belongs to the thioredoxin family
HPE50_RS24345	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPE50_RS24350	COG1215	transferase activity, transferring glycosyl groups
HPE50_RS24355	COG1215	transferase activity, transferring glycosyl groups
HPE50_RS24385	COG2194	sulfuric ester hydrolase activity
HPE50_RS24415	COG0814	amino acid
HPE50_RS24420	COG4608	Belongs to the ABC transporter superfamily
HPE50_RS24425	COG0444	Belongs to the ABC transporter superfamily
HPE50_RS24430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPE50_RS24435	COG0601	transmembrane transport
HPE50_RS24440	COG0747	negative chemotaxis
HPE50_RS24450	COG2194	sulfuric ester hydrolase activity
HPE50_RS24455	COG2223	nitrite transmembrane transporter activity
HPE50_RS24460	COG5571	outer membrane autotransporter
HPE50_RS24465	COG2818	Glycosylase
HPE50_RS24470	COG0456	acetyltransferase
HPE50_RS24480	COG2885	chlorophyll binding
HPE50_RS24495	COG2944	sequence-specific DNA binding
HPE50_RS24500	COG1278	Cold shock
HPE50_RS24530	COG3274	enterobacterial common antigen metabolic process
HPE50_RS24535	COG4682	membrane
HPE50_RS24540	COG4682	membrane
HPE50_RS24555	COG3547	Transposase (IS116 IS110 IS902 family)
HPE50_RS24565	COG4214	carbohydrate transport
HPE50_RS24570	COG1609	Transcriptional regulator
HPE50_RS24570	COG2207	Transcriptional regulator
HPE50_RS24575	COG2992	FlgJ-related protein
HPE50_RS24580	COG0366	Alpha amylase catalytic
HPE50_RS24585	COG3977	Valine--pyruvate aminotransferase
HPE50_RS24590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPE50_RS24595	COG1414	Transcriptional regulator
HPE50_RS24605	COG2731	YhcH YjgK YiaL family protein
HPE50_RS24610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPE50_RS24615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPE50_RS24620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPE50_RS24625	COG1070	Carbohydrate kinase
HPE50_RS24630	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPE50_RS24635	COG3623	hexulose-6-phosphate isomerase
HPE50_RS24640	COG0235	Class ii aldolase
HPE50_RS24650	COG2211	Major facilitator Superfamily
HPE50_RS24660	COG3713	MltA-interacting MipA family protein
HPE50_RS24665	COG0583	DNA-binding transcription factor activity
HPE50_RS24670	COG1566	PFAM secretion protein HlyD family protein
HPE50_RS24685	COG1012	belongs to the aldehyde dehydrogenase family
HPE50_RS24695	COG1454	alcohol dehydrogenase
HPE50_RS24700	COG3276	selenocysteine insertion sequence binding
HPE50_RS24710	COG0625	glutathione transferase activity
HPE50_RS24715	COG1566	PFAM secretion protein HlyD family protein
HPE50_RS24725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS24725	COG2213	PTS system mannitol-specific
HPE50_RS24735	COG3722	fumarate hydratase activity
HPE50_RS24760	COG5295	Hep Hag repeat protein
HPE50_RS24765	COG1620	l-lactate permease
HPE50_RS24770	COG2186	Transcriptional regulator
HPE50_RS24780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPE50_RS24785	COG1045	serine acetyltransferase
HPE50_RS24800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPE50_RS24805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPE50_RS24815	COG4942	peptidase
HPE50_RS24820	COG2861	carbohydrate metabolic process
HPE50_RS24825	COG1216	Glycosyl transferase, family 2
HPE50_RS24835	COG0156	8-amino-7-oxononanoate synthase activity
HPE50_RS24845	COG0859	PFAM glycosyl transferase family 9
HPE50_RS24850	COG0859	PFAM glycosyl transferase family 9
HPE50_RS24855	COG3307	-O-antigen
HPE50_RS24860	COG1216	Glycosyl transferase, family 2
HPE50_RS24865	COG1442	glycosyl transferase family 8
HPE50_RS24870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPE50_RS24885	COG0515	serine threonine protein kinase
HPE50_RS24890	COG0438	transferase activity, transferring glycosyl groups
HPE50_RS24895	COG0859	PFAM glycosyl transferase family 9
HPE50_RS24900	COG1519	Transferase
HPE50_RS24930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPE50_RS24955	COG1561	YicC-like family, N-terminal region
HPE50_RS24965	COG2860	membrane
HPE50_RS24975	COG0194	GDP metabolic process
HPE50_RS24985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPE50_RS24990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPE50_RS24995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPE50_RS25000	COG0786	glutamate:sodium symporter activity
HPE50_RS25005	COG2233	PERMEase
HPE50_RS25010	COG2982	Protein involved in outer membrane biogenesis
HPE50_RS25020	COG1940	carbohydrate kinase activity
HPE50_RS25035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS25035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS25035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS25040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS25045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPE50_RS25045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS25045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPE50_RS25050	COG3711	transcriptional antiterminator
HPE50_RS25055	COG1501	Belongs to the glycosyl hydrolase 31 family
HPE50_RS25060	COG2211	Major facilitator Superfamily
HPE50_RS25075	COG2814	Major facilitator Superfamily
HPE50_RS25080	COG0697	spore germination
HPE50_RS25085	COG1464	Belongs to the NlpA lipoprotein family
HPE50_RS25095	COG0457	Tetratricopeptide repeat
HPE50_RS25135	COG1388	LysM domain
HPE50_RS25135	COG1470	cell adhesion involved in biofilm formation
HPE50_RS25160	COG2252	PERMEase
HPE50_RS25170	COG2271	Major facilitator Superfamily
HPE50_RS25175	COG2271	Major facilitator Superfamily
HPE50_RS25180	COG3851	Histidine kinase
HPE50_RS25185	COG2197	response regulator
HPE50_RS25205	COG0440	acetolactate synthase activity
HPE50_RS25210	COG0028	Belongs to the TPP enzyme family
HPE50_RS25225	COG2814	Major facilitator Superfamily
HPE50_RS25230	COG0641	radical SAM
HPE50_RS25240	COG2149	membrane
HPE50_RS25255	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPE50_RS25260	COG2207	Transcriptional regulator
HPE50_RS25280	COG3385	transposase activity
HPE50_RS25300	COG1522	sequence-specific DNA binding
HPE50_RS25305	COG0716	FMN binding
HPE50_RS25320	COG3312	ion transport
HPE50_RS25370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPE50_RS25395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPE50_RS25400	COG0573	inorganic phosphate transmembrane transporter activity
HPE50_RS25405	COG0581	inorganic phosphate transmembrane transporter activity
HPE50_RS25410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPE50_RS25415	COG0704	Plays a role in the regulation of phosphate uptake
HPE50_RS25435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPE50_RS25440	COG2252	PERMEase
HPE50_RS25445	COG0431	NADPH-dependent FMN reductase
HPE50_RS25450	COG2091	lysine biosynthetic process via aminoadipic acid
HPE50_RS25455	COG0583	DNA-binding transcription factor activity
HPE50_RS25565	COG1192	Involved in chromosome partitioning
HPE50_RS25785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPE50_RS25875	COG2805	Type II/IV secretion system protein
HPE50_RS25910	COG0741	lytic transglycosylase activity
HPE50_RS25925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPE50_RS25965	COG2268	Band 7 protein
HPE50_RS25970	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPE50_RS26020	COG4771	TonB-dependent receptor
HPE50_RS26050	COG3436	PFAM IS66 Orf2 family protein
HPE50_RS26125	COG3039	Transposase
HPE50_RS26145	COG1136	(ABC) transporter
HPE50_RS26145	COG0577	efflux transmembrane transporter activity
HPE50_RS26150	COG0577	efflux transmembrane transporter activity
HPE50_RS26150	COG1136	(ABC) transporter
HPE50_RS26155	COG1136	(ABC) transporter
HPE50_RS26155	COG0577	efflux transmembrane transporter activity
HPE50_RS26170	COG0672	)-iron permease
HPE50_RS26175	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HPE50_RS26180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPE50_RS26595	COG1475	DNA binding
HPE50_RS26825	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HPE50_RS26885	COG2890	protein-(glutamine-N5) methyltransferase activity