locus-tag	class	description
CF58_RS00015	COG1763	Mo-molybdopterin cofactor biosynthetic process
CF58_RS00020	COG0746	molybdenum cofactor guanylyltransferase activity
CF58_RS00025	COG3084	Protein conserved in bacteria
CF58_RS00030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CF58_RS00035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF58_RS00040	COG5339	Protein conserved in bacteria
CF58_RS00045	COG0204	Acyl-transferase
CF58_RS00055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CF58_RS00055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CF58_RS00070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF58_RS00080	COG2204	response regulator
CF58_RS00085	COG3852	Histidine kinase
CF58_RS00090	COG0174	glutamine synthetase
CF58_RS00100	COG1217	gtp-binding protein TYPA
CF58_RS00105	COG2188	Transcriptional regulator
CF58_RS00110	COG1082	Xylose isomerase domain protein TIM barrel
CF58_RS00115	COG2271	Major facilitator Superfamily
CF58_RS00120	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF58_RS00125	COG2211	Major facilitator Superfamily
CF58_RS00130	COG2211	Major facilitator Superfamily
CF58_RS00135	COG1501	Belongs to the glycosyl hydrolase 31 family
CF58_RS00145	COG2017	converts alpha-aldose to the beta-anomer
CF58_RS00150	COG2942	2-epimerase
CF58_RS00155	COG3684	Belongs to the aldolase LacD family
CF58_RS00160	COG2084	Dehydrogenase
CF58_RS00165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF58_RS00170	COG1349	DNA-binding transcription factor activity
CF58_RS00175	COG1011	Hydrolase
CF58_RS00190	COG0456	acetyltransferase
CF58_RS00205	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF58_RS00215	COG2864	formate dehydrogenase
CF58_RS00220	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS00225	COG3383	formate dehydrogenase (NAD+) activity
CF58_RS00225	COG0243	molybdopterin cofactor binding
CF58_RS00230	COG3383	formate dehydrogenase (NAD+) activity
CF58_RS00230	COG0243	molybdopterin cofactor binding
CF58_RS00245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS00245	COG3711	transcriptional antiterminator
CF58_RS00250	COG1363	Peptidase, m42
CF58_RS00255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS00255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS00260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS00310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CF58_RS00325	COG2258	MOSC domain
CF58_RS00340	COG2801	Transposase and inactivated derivatives
CF58_RS00345	COG2205	protein histidine kinase activity
CF58_RS00350	COG0745	RESPONSE REGULATOR receiver
CF58_RS00355	COG3678	ATP-independent chaperone mediated protein folding
CF58_RS00370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CF58_RS00390	COG3152	Membrane
CF58_RS00395	COG3691	Protein conserved in bacteria
CF58_RS00400	COG0589	response to stress
CF58_RS00410	COG1494	fructose-1,6-bisphosphatase
CF58_RS00420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CF58_RS00435	COG1575	Belongs to the MenA family. Type 1 subfamily
CF58_RS00450	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF58_RS00455	COG1609	Transcriptional regulator
CF58_RS00460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CF58_RS00475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF58_RS00485	COG5433	transposase activity
CF58_RS00495	COG3209	COG3209 Rhs family protein
CF58_RS00520	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CF58_RS00530	COG0626	cystathionine gamma-synthase activity
CF58_RS00535	COG0460	homoserine dehydrogenase
CF58_RS00535	COG0527	aspartate kinase activity
CF58_RS00545	COG0737	Belongs to the 5'-nucleotidase family
CF58_RS00550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CF58_RS00560	COG0697	spore germination
CF58_RS00565	COG3738	Protein conserved in bacteria
CF58_RS00570	COG0371	Dehydrogenase
CF58_RS00575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF58_RS00580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS00580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS00580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF58_RS00585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS00590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS00595	COG1882	Formate acetyltransferase
CF58_RS00600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF58_RS00605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS00610	COG2207	Transcriptional regulator
CF58_RS00615	COG2194	sulfuric ester hydrolase activity
CF58_RS00630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CF58_RS00645	COG0583	DNA-binding transcription factor activity
CF58_RS00670	COG4206	TonB-dependent receptor
CF58_RS00700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CF58_RS00705	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CF58_RS00705	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CF58_RS00745	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF58_RS00750	COG0250	Participates in transcription elongation, termination and antitermination
CF58_RS00785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CF58_RS00795	COG2104	thiamine diphosphate biosynthetic process
CF58_RS00800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CF58_RS00835	COG3068	Protein conserved in bacteria
CF58_RS00850	COG3678	ATP-independent chaperone mediated protein folding
CF58_RS00855	COG4191	Histidine kinase
CF58_RS00860	COG2204	response regulator
CF58_RS00865	COG0151	Belongs to the GarS family
CF58_RS00895	COG0456	acetyltransferase
CF58_RS00905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CF58_RS00910	COG2224	Isocitrate lyase
CF58_RS00925	COG1414	Transcriptional regulator
CF58_RS00930	COG0646	methionine synthase
CF58_RS00930	COG1410	methionine synthase
CF58_RS00945	COG1283	sodium-dependent phosphate transmembrane transporter activity
CF58_RS00995	COG1187	pseudouridine synthase activity
CF58_RS01005	COG0527	aspartate kinase activity
CF58_RS01030	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF58_RS01050	COG2814	Major facilitator Superfamily
CF58_RS01050	COG0477	Major facilitator Superfamily
CF58_RS01055	COG3833	ABC-type maltose transport systems, permease component
CF58_RS01060	COG1175	transmembrane transport
CF58_RS01065	COG2182	Extracellular solute-binding protein
CF58_RS01075	COG3842	ATPase activity
CF58_RS01090	COG1357	PFAM Pentapeptide repeats (8 copies)
CF58_RS01110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CF58_RS01120	COG0534	Mate efflux family protein
CF58_RS01125	COG3237	CsbD-like
CF58_RS01130	COG0735	belongs to the Fur family
CF58_RS01145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF58_RS01155	COG0604	alcohol dehydrogenase
CF58_RS01160	COG0305	Participates in initiation and elongation during chromosome replication
CF58_RS01165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CF58_RS01170	COG1448	Aminotransferase
CF58_RS01180	COG3700	Belongs to the class B bacterial acid phosphatase family
CF58_RS01185	COG0432	Pfam Uncharacterised protein family UPF0047
CF58_RS01190	COG2315	Protein conserved in bacteria
CF58_RS01195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CF58_RS01200	COG0629	single-stranded DNA binding
CF58_RS01210	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CF58_RS01215	COG2207	Transcriptional regulator
CF58_RS01220	COG0789	Transcriptional regulator
CF58_RS01225	COG2252	PERMEase
CF58_RS01230	COG0025	NhaP-type Na H and K H
CF58_RS01235	COG1357	PFAM Pentapeptide repeats (8 copies)
CF58_RS01245	COG3162	membrane
CF58_RS01250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF58_RS01260	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CF58_RS01265	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS01270	COG3301	Polysulphide reductase, NrfD
CF58_RS01275	COG1138	Cytochrome C-type biogenesis protein
CF58_RS01280	COG3088	subunit of a heme lyase
CF58_RS01285	COG4235	cytochrome complex assembly
CF58_RS01290	COG1301	dicarboxylic acid transport
CF58_RS01295	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF58_RS01300	COG3383	formate dehydrogenase (NAD+) activity
CF58_RS01305	COG3383	formate dehydrogenase (NAD+) activity
CF58_RS01315	COG1289	transmembrane transporter activity
CF58_RS01320	COG1566	PFAM secretion protein HlyD family protein
CF58_RS01330	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CF58_RS01335	COG1940	carbohydrate kinase activity
CF58_RS01340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CF58_RS01345	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF58_RS01350	COG1129	ABC transporter
CF58_RS01355	COG1879	ABC-type sugar transport system periplasmic component
CF58_RS01360	COG1737	Transcriptional regulator
CF58_RS01365	COG0698	ribose 5-phosphate isomerase
CF58_RS01375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CF58_RS01380	COG0456	acetyltransferase
CF58_RS01390	COG3454	Phosphonate metabolism
CF58_RS01395	COG4778	phosphonate C-P lyase system protein PhnL
CF58_RS01400	COG4107	phosphonate C-P lyase system protein PhnK
CF58_RS01405	COG3627	carbon phosphorus lyase activity
CF58_RS01410	COG3626	phosphonate metabolism
CF58_RS01415	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CF58_RS01420	COG3624	Phosphonate C-P lyase system protein PhnG
CF58_RS01425	COG2188	Transcriptional regulator
CF58_RS01430	COG3639	organic phosphonate transmembrane transporter activity
CF58_RS01435	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CF58_RS01445	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CF58_RS01450	COG2824	Alkylphosphonate utilization operon protein PhnA
CF58_RS01465	COG0477	Major facilitator Superfamily
CF58_RS01475	COG0642	Histidine kinase
CF58_RS01480	COG0745	RESPONSE REGULATOR receiver
CF58_RS01485	COG2194	sulfuric ester hydrolase activity
CF58_RS01490	COG0531	amino acid
CF58_RS01495	COG2207	Transcriptional regulator
CF58_RS01500	COG1982	Orn Lys Arg decarboxylase major
CF58_RS01505	COG2169	Transcriptional regulator
CF58_RS01515	COG1486	melibiose metabolic process
CF58_RS01520	COG2211	Major facilitator Superfamily
CF58_RS01530	COG3647	Membrane
CF58_RS01535	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF58_RS01535	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF58_RS01540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF58_RS01550	COG4565	transcriptional regulatory protein
CF58_RS01555	COG3290	protein histidine kinase activity
CF58_RS01560	COG3592	Divergent 4Fe-4S mono-cluster
CF58_RS01565	COG2388	GCN5-related N-acetyl-transferase
CF58_RS01580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CF58_RS01585	COG3104	oligopeptide transport
CF58_RS01590	COG1982	Orn Lys Arg decarboxylase major
CF58_RS01595	COG0531	amino acid
CF58_RS01600	COG3710	Transcriptional regulator
CF58_RS01610	COG1309	transcriptional regulator
CF58_RS01615	COG4232	protein-disulfide reductase activity
CF58_RS01625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF58_RS01630	COG1027	Aspartate ammonia-lyase
CF58_RS01635	COG3030	protein affecting phage T7 exclusion by the F plasmid
CF58_RS01640	COG0531	amino acid
CF58_RS01665	COG1509	lysine 2,3-aminomutase activity
CF58_RS01675	COG5510	response to toxic substance
CF58_RS01680	COG5510	response to toxic substance
CF58_RS01685	COG2076	Multidrug Resistance protein
CF58_RS01690	COG3040	lipid binding
CF58_RS01695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF58_RS01710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CF58_RS01715	COG1053	succinate dehydrogenase
CF58_RS01725	COG0531	amino acid
CF58_RS01730	COG3264	Mechanosensitive ion channel
CF58_RS01730	COG1511	domain protein
CF58_RS01770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CF58_RS01770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CF58_RS01775	COG0802	atpase or kinase
CF58_RS01780	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF58_RS01800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CF58_RS01805	COG0330	HflC and HflK could
CF58_RS01810	COG0330	HflC and HflK could
CF58_RS01815	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CF58_RS01830	COG0557	exoribonuclease II activity
CF58_RS01835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF58_RS01840	COG3789	protein conserved in bacteria
CF58_RS01845	COG1842	Phage shock protein A
CF58_RS01855	COG3766	membrane
CF58_RS01860	COG5463	Belongs to the UPF0441 family
CF58_RS01865	COG0754	glutathionylspermidine amidase activity
CF58_RS01870	COG1960	acyl-CoA dehydrogenase activity
CF58_RS01880	COG3650	response to hydrogen peroxide
CF58_RS01885	COG1073	alpha beta
CF58_RS01900	COG3037	sugar-specific permease SgaT UlaA
CF58_RS01945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CF58_RS01960	COG1309	transcriptional regulator
CF58_RS01965	COG3061	Opacity-associated protein A
CF58_RS01970	COG0545	Peptidyl-prolyl cis-trans isomerase
CF58_RS01975	COG1113	amino acid transport
CF58_RS01985	COG0697	spore germination
CF58_RS01990	COG0702	epimerase
CF58_RS01995	COG1733	regulation of RNA biosynthetic process
CF58_RS02000	COG0737	Belongs to the 5'-nucleotidase family
CF58_RS02005	COG1218	3'(2'),5'-bisphosphate nucleotidase
CF58_RS02015	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CF58_RS02025	COG1253	flavin adenine dinucleotide binding
CF58_RS02040	COG0729	surface antigen
CF58_RS02045	COG2911	Protein conserved in bacteria
CF58_RS02050	COG2105	PFAM AIG2 family protein
CF58_RS02055	COG2336	PFAM SpoVT AbrB
CF58_RS02060	COG2337	Toxic component of a toxin-antitoxin (TA) module
CF58_RS02065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CF58_RS02070	COG1879	ABC-type sugar transport system periplasmic component
CF58_RS02075	COG1129	ABC transporter
CF58_RS02080	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF58_RS02085	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF58_RS02095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CF58_RS02105	COG0312	modulator of DNA gyrase
CF58_RS02110	COG3783	Cytochrome b(562)
CF58_RS02115	COG3077	Addiction module antitoxin, RelB DinJ family
CF58_RS02120	COG2026	Addiction module toxin, RelE StbE family
CF58_RS02125	COG0602	queuosine metabolic process
CF58_RS02135	COG1328	CTP reductase activity
CF58_RS02140	COG0366	Alpha amylase catalytic
CF58_RS02145	COG1263	PTS System
CF58_RS02145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS02150	COG1609	Transcriptional regulator
CF58_RS02155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CF58_RS02160	COG0251	oxidation-reduction process
CF58_RS02185	COG0251	oxidation-reduction process
CF58_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS02195	COG1309	transcriptional regulator
CF58_RS02200	COG2731	YhcH YjgK YiaL family protein
CF58_RS02215	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CF58_RS02220	COG0456	acetyltransferase
CF58_RS02225	COG4269	membrane
CF58_RS02230	COG0525	valine-tRNA ligase activity
CF58_RS02235	COG2927	DNA polymerase III (CHI subunit)
CF58_RS02245	COG0795	lipopolysaccharide-transporting ATPase activity
CF58_RS02250	COG0795	lipopolysaccharide-transporting ATPase activity
CF58_RS02255	COG0433	COG0433 Predicted ATPase
CF58_RS02260	COG0433	COG0433 Predicted ATPase
CF58_RS02265	COG1064	alcohol dehydrogenase
CF58_RS02275	COG0582	viral genome integration into host DNA
CF58_RS02280	COG2801	Transposase and inactivated derivatives
CF58_RS02285	COG2963	transposase activity
CF58_RS02340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CF58_RS02385	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF58_RS02400	COG0582	viral genome integration into host DNA
CF58_RS02405	COG4974	Belongs to the 'phage' integrase family
CF58_RS02420	COG3539	Fimbrial protein
CF58_RS02425	COG3121	Chaperone
CF58_RS02430	COG3188	usher protein
CF58_RS02435	COG3539	Fimbrial protein
CF58_RS02440	COG3539	Fimbrial protein
CF58_RS02445	COG3539	Fimbrial protein
CF58_RS02450	COG2610	gluconate transmembrane transporter activity
CF58_RS02465	COG0246	Mannitol dehydrogenase
CF58_RS02475	COG2186	Transcriptional regulator
CF58_RS02495	COG0583	DNA-binding transcription factor activity
CF58_RS02500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF58_RS02505	COG0700	Nucleoside recognition
CF58_RS02510	COG3366	ferrous iron transmembrane transporter activity
CF58_RS02520	COG1388	LysM domain
CF58_RS02520	COG1470	cell adhesion involved in biofilm formation
CF58_RS02525	COG0477	Major facilitator Superfamily
CF58_RS02530	COG3204	pilus organization
CF58_RS02545	COG1924	4 iron, 4 sulfur cluster binding
CF58_RS02550	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CF58_RS02555	COG2733	membrane
CF58_RS02560	COG2814	Major facilitator Superfamily
CF58_RS02570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF58_RS02575	COG5457	Domain of unknown function (DUF1127)
CF58_RS02590	COG0732	type I restriction modification DNA specificity domain
CF58_RS02615	COG0523	cobalamin synthesis protein
CF58_RS02620	COG2879	small protein
CF58_RS02625	COG1966	Carbon starvation protein
CF58_RS02635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CF58_RS02640	COG2368	4-hydroxyphenylacetate
CF58_RS02645	COG1234	tRNA 3'-trailer cleavage
CF58_RS02665	COG3971	2-oxopent-4-enoate hydratase activity
CF58_RS02675	COG3384	dioxygenase
CF58_RS02680	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS02685	COG0179	Fumarylacetoacetate (FAA) hydrolase
CF58_RS02690	COG1846	Transcriptional regulator
CF58_RS02695	COG0840	transmembrane signaling receptor activity
CF58_RS02700	COG2271	Major facilitator Superfamily
CF58_RS02705	COG1802	Transcriptional regulator
CF58_RS02710	COG1063	alcohol dehydrogenase
CF58_RS02725	COG1484	DNA-dependent DNA replication
CF58_RS02740	COG2966	Psort location CytoplasmicMembrane, score
CF58_RS02745	COG2197	response regulator
CF58_RS02750	COG2197	response regulator
CF58_RS02755	COG4114	ferric iron reductase
CF58_RS02790	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CF58_RS02795	COG0456	acetyltransferase
CF58_RS02800	COG1011	Hydrolase
CF58_RS02810	COG2823	Periplasmic or secreted lipoprotein
CF58_RS02820	COG4667	esterase of the alpha-beta hydrolase superfamily
CF58_RS02825	COG0084	hydrolase, TatD family'
CF58_RS02830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF58_RS02835	COG1328	CTP reductase activity
CF58_RS02875	COG3726	membrane protein affecting hemolysin expression
CF58_RS02880	COG0560	Phosphoserine phosphatase
CF58_RS02885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CF58_RS02890	COG3172	ATPase kinase involved in NAD metabolism
CF58_RS02890	COG1056	cytidyltransferase-related domain
CF58_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS02935	COG0583	DNA-binding transcription factor activity
CF58_RS02940	COG0488	(ABC) transporter
CF58_RS02945	COG0741	lytic transglycosylase activity
CF58_RS02965	COG3708	Transcriptional regulator
CF58_RS02965	COG2207	Transcriptional regulator
CF58_RS02970	COG3045	CreA protein
CF58_RS02975	COG0745	RESPONSE REGULATOR receiver
CF58_RS02980	COG2205	protein histidine kinase activity
CF58_RS02985	COG4452	Inner membrane protein CreD
CF58_RS02990	COG0745	RESPONSE REGULATOR receiver
CF58_RS03000	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CF58_RS03010	COG0527	aspartate kinase activity
CF58_RS03010	COG0460	homoserine dehydrogenase
CF58_RS03020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CF58_RS03040	COG1115	amino acid carrier protein
CF58_RS03050	COG0521	Mo-molybdopterin cofactor biosynthetic process
CF58_RS03055	COG1584	GPR1 FUN34 yaaH family protein
CF58_RS03060	COG4735	regulation of single-species biofilm formation
CF58_RS03090	COG3119	arylsulfatase activity
CF58_RS03105	COG0583	DNA-binding transcription factor activity
CF58_RS03115	COG3188	usher protein
CF58_RS03120	COG3121	Chaperone
CF58_RS03145	COG0196	riboflavin kinase activity
CF58_RS03160	COG1047	Peptidyl-prolyl cis-trans
CF58_RS03190	COG0505	Belongs to the CarA family
CF58_RS03195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CF58_RS03250	COG0644	oxidoreductase
CF58_RS03255	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF58_RS03260	COG2271	Major facilitator Superfamily
CF58_RS03275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CF58_RS03300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF58_RS03305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF58_RS03310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CF58_RS03315	COG1357	PFAM Pentapeptide repeats (8 copies)
CF58_RS03320	COG0564	pseudouridine synthase activity
CF58_RS03330	COG0417	DNA replication proofreading
CF58_RS03335	COG0235	Class ii aldolase
CF58_RS03350	COG4977	sequence-specific DNA binding
CF58_RS03355	COG0586	Pfam SNARE associated Golgi protein
CF58_RS03365	COG1178	ABC-type Fe3 transport system permease component
CF58_RS03370	COG4143	(ABC) transporter
CF58_RS03400	COG0473	3-isopropylmalate dehydrogenase activity
CF58_RS03415	COG0583	DNA-binding transcription factor activity
CF58_RS03420	COG0028	Belongs to the TPP enzyme family
CF58_RS03425	COG0440	acetolactate synthase activity
CF58_RS03435	COG1609	Transcriptional regulator
CF58_RS03450	COG3116	cell division
CF58_RS03455	COG0768	penicillin binding
CF58_RS03460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CF58_RS03465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CF58_RS03480	COG0772	Belongs to the SEDS family
CF58_RS03495	COG1181	Belongs to the D-alanine--D-alanine ligase family
CF58_RS03500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CF58_RS03505	COG0849	cell division
CF58_RS03510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CF58_RS03530	COG0494	nUDIX hydrolase
CF58_RS03550	COG0237	dephospho-CoA kinase activity
CF58_RS03560	COG1459	type II secretion system
CF58_RS03565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF58_RS03570	COG4969	Belongs to the N-Me-Phe pilin family
CF58_RS03580	COG0157	Belongs to the NadC ModD family
CF58_RS03585	COG3023	N-Acetylmuramoyl-L-alanine amidase
CF58_RS03590	COG3725	Membrane protein required for beta-lactamase induction
CF58_RS03595	COG1113	amino acid transport
CF58_RS03600	COG2186	Transcriptional regulator
CF58_RS03605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CF58_RS03610	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF58_RS03615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF58_RS03620	COG3064	Membrane
CF58_RS03625	COG1049	propionate catabolic process, 2-methylcitrate cycle
CF58_RS03650	COG2132	Multicopper oxidase
CF58_RS03655	COG4993	Dehydrogenase
CF58_RS03660	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CF58_RS03665	COG0288	reversible hydration of carbon dioxide
CF58_RS03670	COG1131	(ABC) transporter
CF58_RS03675	COG0842	Transport permease protein
CF58_RS03680	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS03685	COG0726	polysaccharide deacetylase
CF58_RS03695	COG5464	transposase or invertase
CF58_RS03715	COG3539	Fimbrial protein
CF58_RS03720	COG3539	Fimbrial protein
CF58_RS03725	COG3539	Fimbrial protein
CF58_RS03730	COG3188	usher protein
CF58_RS03735	COG3121	Chaperone
CF58_RS03740	COG3539	Fimbrial protein
CF58_RS03745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CF58_RS03750	COG0617	tRNA 3'-terminal CCA addition
CF58_RS03755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CF58_RS03760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CF58_RS03770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CF58_RS03775	COG1643	Atp-dependent helicase
CF58_RS03780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CF58_RS03785	COG4774	siderophore transport
CF58_RS03790	COG1120	ATPase activity
CF58_RS03795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF58_RS03800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF58_RS03820	COG2860	membrane
CF58_RS03825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF58_RS03840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF58_RS03845	COG3835	regulator
CF58_RS03865	COG0024	Methionine aminopeptidase
CF58_RS03890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CF58_RS03895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CF58_RS03900	COG0575	Belongs to the CDS family
CF58_RS03905	COG0750	zinc metalloprotease
CF58_RS03915	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CF58_RS03920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CF58_RS03940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CF58_RS03945	COG0587	DNA-directed DNA polymerase activity
CF58_RS03955	COG1982	Orn Lys Arg decarboxylase major
CF58_RS03960	COG0346	lactoylglutathione lyase activity
CF58_RS03965	COG0037	tRNA processing
CF58_RS03970	COG4568	rho-dependent transcription termination
CF58_RS03980	COG4681	YaeQ
CF58_RS03985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CF58_RS03990	COG3015	lipoprotein NlpE involved in copper resistance
CF58_RS03995	COG0791	NLP P60 protein
CF58_RS04005	COG1720	tRNA m6t6A37 methyltransferase activity
CF58_RS04015	COG1464	Belongs to the NlpA lipoprotein family
CF58_RS04020	COG2011	ABC-type metal ion transport system permease component
CF58_RS04025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CF58_RS04030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CF58_RS04065	COG0656	L-ascorbic acid biosynthetic process
CF58_RS04070	COG0583	DNA-binding transcription factor activity
CF58_RS04080	COG2226	methyltransferase
CF58_RS04085	COG0741	lytic transglycosylase activity
CF58_RS04085	COG1388	LysM domain
CF58_RS04095	COG2226	methyltransferase
CF58_RS04105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF58_RS04125	COG4104	PAAR repeat-containing protein
CF58_RS04130	COG3157	Type VI secretion system effector, Hcp
CF58_RS04240	COG5433	transposase activity
CF58_RS04245	COG3328	transposase activity
CF58_RS04250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF58_RS04260	COG1960	acyl-CoA dehydrogenase activity
CF58_RS04270	COG0121	glutamine amidotransferase
CF58_RS04275	COG3034	peptidoglycan biosynthetic process
CF58_RS04280	COG0791	NLP P60 protein
CF58_RS04310	COG2161	toxin-antitoxin pair type II binding
CF58_RS04320	COG0454	-acetyltransferase
CF58_RS04325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CF58_RS04330	COG2195	Cleaves the N-terminal amino acid of tripeptides
CF58_RS04350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF58_RS04370	COG0582	viral genome integration into host DNA
CF58_RS04375	COG3423	Transcriptional regulator
CF58_RS04400	COG0583	DNA-binding transcription factor activity
CF58_RS04415	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CF58_RS04420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF58_RS04425	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF58_RS04430	COG2080	2 iron, 2 sulfur cluster binding
CF58_RS04435	COG3477	response to acidic pH
CF58_RS04440	COG0727	PFAM Uncharacterised protein family (UPF0153)
CF58_RS04490	COG1902	pentaerythritol trinitrate reductase activity
CF58_RS04495	COG1073	alpha beta
CF58_RS04500	COG0583	DNA-binding transcription factor activity
CF58_RS04510	COG0667	Aldo Keto reductase
CF58_RS04515	COG0656	L-ascorbic acid biosynthetic process
CF58_RS04520	COG1388	LysM domain
CF58_RS04525	COG2207	Transcriptional regulator
CF58_RS04525	COG3708	Transcriptional regulator
CF58_RS04530	COG0656	L-ascorbic acid biosynthetic process
CF58_RS04535	COG3059	membrane
CF58_RS04545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF58_RS04550	COG2207	Transcriptional regulator
CF58_RS04555	COG0247	lactate metabolic process
CF58_RS04560	COG1139	Iron-sulfur cluster binding protein
CF58_RS04565	COG1556	Lactate utilization protein
CF58_RS04595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CF58_RS04605	COG2771	luxR family
CF58_RS04605	COG2200	EAL domain
CF58_RS04610	COG0583	DNA-binding transcription factor activity
CF58_RS04620	COG0666	response to abiotic stimulus
CF58_RS04630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF58_RS04635	COG1304	FMN binding
CF58_RS04640	COG0549	Belongs to the carbamate kinase family
CF58_RS04645	COG0402	S-adenosylhomocysteine deaminase activity
CF58_RS04655	COG1879	ABC-type sugar transport system periplasmic component
CF58_RS04660	COG1129	ABC transporter
CF58_RS04665	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF58_RS04675	COG1064	alcohol dehydrogenase
CF58_RS04690	COG1280	lysine exporter protein (LysE YggA)
CF58_RS04700	COG3829	transcription factor binding
CF58_RS04705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CF58_RS04710	COG0372	Belongs to the citrate synthase family
CF58_RS04715	COG2079	MmgE PrpD family protein
CF58_RS04720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF58_RS04725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CF58_RS04730	COG0402	S-adenosylhomocysteine deaminase activity
CF58_RS04735	COG0583	DNA-binding transcription factor activity
CF58_RS04740	COG0288	reversible hydration of carbon dioxide
CF58_RS04750	COG2807	transmembrane transport
CF58_RS04755	COG0110	maltose O-acetyltransferase activity
CF58_RS04760	COG2223	nitrite transmembrane transporter activity
CF58_RS04770	COG1609	Transcriptional regulator
CF58_RS04775	COG1414	Transcriptional regulator
CF58_RS04810	COG2814	Major facilitator Superfamily
CF58_RS04815	COG3122	Protein conserved in bacteria
CF58_RS04845	COG1215	transferase activity, transferring glycosyl groups
CF58_RS04850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CF58_RS04855	COG4521	taurine ABC transporter
CF58_RS04860	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CF58_RS04865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CF58_RS04870	COG2175	clavaminate synthase activity
CF58_RS04875	COG0113	porphobilinogen synthase activity
CF58_RS04880	COG3468	outer membrane autotransporter barrel domain protein
CF58_RS04885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF58_RS04890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF58_RS04900	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CF58_RS04920	COG1181	Belongs to the D-alanine--D-alanine ligase family
CF58_RS04935	COG1785	Belongs to the alkaline phosphatase family
CF58_RS04945	COG3706	GGDEF domain
CF58_RS04950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CF58_RS04975	COG4126	flavin adenine dinucleotide binding
CF58_RS04995	COG1940	carbohydrate kinase activity
CF58_RS05000	COG2814	Major facilitator Superfamily
CF58_RS05005	COG0419	ATPase involved in DNA repair
CF58_RS05010	COG0420	3'-5' exonuclease activity
CF58_RS05015	COG0745	RESPONSE REGULATOR receiver
CF58_RS05020	COG5002	protein histidine kinase activity
CF58_RS05025	COG1114	Component of the transport system for branched-chain amino acids
CF58_RS05030	COG1113	amino acid transport
CF58_RS05035	COG0366	Alpha amylase catalytic
CF58_RS05060	COG1862	Preprotein translocase
CF58_RS05065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF58_RS05070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF58_RS05075	COG1403	HNH endonuclease
CF58_RS05085	COG3248	Nucleoside-binding outer membrane protein
CF58_RS05090	COG4238	major outer membrane lipoprotein
CF58_RS05105	COG0675	Transposase, IS605 OrfB family
CF58_RS05110	COG4238	major outer membrane lipoprotein
CF58_RS05120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF58_RS05120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF58_RS05135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CF58_RS05140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CF58_RS05150	COG0667	Aldo Keto reductase
CF58_RS05160	COG0142	geranyltranstransferase activity
CF58_RS05175	COG0693	protein deglycase activity
CF58_RS05180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CF58_RS05190	COG2814	Major facilitator Superfamily
CF58_RS05200	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CF58_RS05205	COG1845	cytochrome c oxidase, subunit III
CF58_RS05210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CF58_RS05215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CF58_RS05220	COG2223	nitrite transmembrane transporter activity
CF58_RS05225	COG3056	Lipoprotein
CF58_RS05230	COG0271	Belongs to the BolA IbaG family
CF58_RS05255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CF58_RS05260	COG0776	regulation of translation
CF58_RS05265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF58_RS05270	COG1555	photosystem II stabilization
CF58_RS05275	COG0824	Thioesterase
CF58_RS05285	COG4533	DNA binding
CF58_RS05295	COG1522	sequence-specific DNA binding
CF58_RS05300	COG1132	(ABC) transporter
CF58_RS05305	COG1132	(ABC) transporter
CF58_RS05310	COG0347	Belongs to the P(II) protein family
CF58_RS05315	COG0004	ammonium transporteR
CF58_RS05320	COG1946	Acyl-CoA thioesterase
CF58_RS05325	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CF58_RS05330	COG3695	enzyme binding
CF58_RS05335	COG5507	3-demethylubiquinone-9 3-methyltransferase
CF58_RS05340	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CF58_RS05350	COG0110	maltose O-acetyltransferase activity
CF58_RS05365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF58_RS05370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF58_RS05375	COG1309	transcriptional regulator
CF58_RS05380	COG3264	Mechanosensitive ion channel
CF58_RS05380	COG1196	nuclear chromosome segregation
CF58_RS05390	COG3923	Primosomal replication protein n
CF58_RS05395	COG2832	Protein of unknown function (DUF454)
CF58_RS05405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CF58_RS05440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF58_RS05445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CF58_RS05445	COG4651	solute:proton antiporter activity
CF58_RS05450	COG2223	nitrite transmembrane transporter activity
CF58_RS05455	COG0737	Belongs to the 5'-nucleotidase family
CF58_RS05460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CF58_RS05465	COG3735	TraB family
CF58_RS05470	COG2217	Heavy metal translocating P-type atpase
CF58_RS05480	COG0531	amino acid
CF58_RS05510	COG0789	Transcriptional regulator
CF58_RS05535	COG1585	Membrane protein implicated in regulation of membrane protease activity
CF58_RS05540	COG0330	HflC and HflK could
CF58_RS05545	COG4619	ABC transporter
CF58_RS05550	COG0390	transport system, permease component
CF58_RS05555	COG3118	belongs to the thioredoxin family
CF58_RS05560	COG0300	oxidoreductase activity
CF58_RS05565	COG2755	lipolytic protein G-D-S-L family
CF58_RS05570	COG4181	ATPase activity
CF58_RS05575	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CF58_RS05580	COG3209	COG3209 Rhs family protein
CF58_RS05590	COG2801	Transposase and inactivated derivatives
CF58_RS05600	COG0583	DNA-binding transcription factor activity
CF58_RS05610	COG1414	Transcriptional regulator
CF58_RS05615	COG3960	tartronate-semialdehyde synthase activity
CF58_RS05620	COG3622	Belongs to the hyi family
CF58_RS05625	COG2084	Dehydrogenase
CF58_RS05630	COG1953	Uracil, thiamine, allantoin
CF58_RS05640	COG2233	PERMEase
CF58_RS05645	COG1929	Belongs to the glycerate kinase type-1 family
CF58_RS05650	COG3257	ureidoglycine aminohydrolase activity
CF58_RS05655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CF58_RS05660	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CF58_RS05665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF58_RS05670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF58_RS05680	COG0549	Belongs to the carbamate kinase family
CF58_RS05685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CF58_RS05690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CF58_RS05700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CF58_RS05710	COG1988	membrane-bound metal-dependent
CF58_RS05715	COG2501	S4 domain
CF58_RS05725	COG3539	Fimbrial protein
CF58_RS05730	COG3121	Chaperone
CF58_RS05735	COG3188	usher protein
CF58_RS05740	COG3539	Fimbrial protein
CF58_RS05745	COG3539	Fimbrial protein
CF58_RS05750	COG2197	response regulator
CF58_RS05760	COG0582	viral genome integration into host DNA
CF58_RS05845	COG2076	Multidrug Resistance protein
CF58_RS05855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF58_RS05860	COG1881	PFAM PEBP family protein
CF58_RS05865	COG2207	Transcriptional regulator
CF58_RS05910	COG3772	lysozyme
CF58_RS05930	COG5562	phage envelope protein
CF58_RS05950	COG4220	transposase activity
CF58_RS05970	COG1030	water channel activity
CF58_RS06020	COG1196	nuclear chromosome segregation
CF58_RS06055	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF58_RS06080	COG2207	Transcriptional regulator
CF58_RS06085	COG4571	Outer membrane protease
CF58_RS06095	COG2207	Transcriptional regulator
CF58_RS06105	COG4783	chaperone-mediated protein folding
CF58_RS06110	COG1215	transferase activity, transferring glycosyl groups
CF58_RS06115	COG5433	transposase activity
CF58_RS06125	COG3209	COG3209 Rhs family protein
CF58_RS06125	COG4104	PAAR repeat-containing protein
CF58_RS06155	COG3209	COG3209 Rhs family protein
CF58_RS06155	COG4104	PAAR repeat-containing protein
CF58_RS06170	COG5002	protein histidine kinase activity
CF58_RS06175	COG0745	RESPONSE REGULATOR receiver
CF58_RS06180	COG1538	Outer membrane efflux protein
CF58_RS06185	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF58_RS06190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF58_RS06195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF58_RS06200	COG1113	amino acid transport
CF58_RS06205	COG0668	transmembrane transport
CF58_RS06210	COG0778	Nitroreductase
CF58_RS06215	COG2315	Protein conserved in bacteria
CF58_RS06235	COG2963	transposase activity
CF58_RS06240	COG2801	Transposase and inactivated derivatives
CF58_RS06250	COG2977	Belongs to the P-Pant transferase superfamily
CF58_RS06260	COG4771	TonB-dependent receptor
CF58_RS06265	COG2382	esterase
CF58_RS06270	COG3251	PFAM MbtH domain protein
CF58_RS06275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CF58_RS06275	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CF58_RS06280	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF58_RS06285	COG1120	ATPase activity
CF58_RS06290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF58_RS06295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF58_RS06305	COG4592	Periplasmic binding protein
CF58_RS06310	COG1169	isochorismate synthase
CF58_RS06315	COG1021	2,3-dihydroxybenzoate-AMP ligase
CF58_RS06320	COG3433	isochorismatase activity
CF58_RS06320	COG1535	isochorismatase
CF58_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS06335	COG1966	Carbon starvation protein
CF58_RS06340	COG2879	small protein
CF58_RS06345	COG0371	Dehydrogenase
CF58_RS06350	COG0436	Aminotransferase
CF58_RS06355	COG1475	DNA binding
CF58_RS06360	COG3969	phosphoadenosine phosphosulfate
CF58_RS06365	COG0583	DNA-binding transcription factor activity
CF58_RS06370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF58_RS06375	COG0450	alkyl hydroperoxide reductase
CF58_RS06380	COG3634	alkyl hydroperoxide reductase activity
CF58_RS06385	COG0589	response to stress
CF58_RS06390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF58_RS06395	COG3719	Belongs to the RNase T2 family
CF58_RS06400	COG0471	metal ion transport
CF58_RS06415	COG3051	citrate lyase alpha subunit
CF58_RS06420	COG2301	Belongs to the HpcH HpaI aldolase family
CF58_RS06430	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CF58_RS06435	COG3290	protein histidine kinase activity
CF58_RS06440	COG4565	transcriptional regulatory protein
CF58_RS06445	COG3069	C4-dicarboxylate transmembrane transporter activity
CF58_RS06465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF58_RS06470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF58_RS06480	COG0583	DNA-binding transcription factor activity
CF58_RS06500	COG1686	Belongs to the peptidase S11 family
CF58_RS06505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF58_RS06510	COG0772	Belongs to the SEDS family
CF58_RS06515	COG0768	penicillin binding
CF58_RS06525	COG0799	negative regulation of ribosome biogenesis
CF58_RS06530	COG0406	alpha-ribazole phosphatase activity
CF58_RS06540	COG1466	dna polymerase III delta subunit
CF58_RS06555	COG2888	peptidyl-tyrosine sulfation
CF58_RS06565	COG1126	abc transporter atp-binding protein
CF58_RS06570	COG0765	amino acid transport
CF58_RS06575	COG0765	amino acid transport
CF58_RS06580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS06585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CF58_RS06590	COG4535	Mg2 and Co2 transporter CorC
CF58_RS06600	COG1702	phosphate starvation-inducible protein PhoH
CF58_RS06610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF58_RS06650	COG0367	asparagine synthase
CF58_RS06655	COG0647	UMP catabolic process
CF58_RS06660	COG1846	Transcriptional regulator
CF58_RS06660	COG1940	carbohydrate kinase activity
CF58_RS06665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF58_RS06675	COG2190	(PTS) system
CF58_RS06675	COG1263	PTS System
CF58_RS06675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS06695	COG0735	belongs to the Fur family
CF58_RS06710	COG0716	FMN binding
CF58_RS06720	COG0596	Alpha beta hydrolase
CF58_RS06725	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CF58_RS06730	COG0033	Phosphoglucomutase
CF58_RS06745	COG0745	RESPONSE REGULATOR receiver
CF58_RS06750	COG2205	protein histidine kinase activity
CF58_RS06780	COG3209	COG3209 Rhs family protein
CF58_RS06790	COG3272	Protein of unknown function (DUF1722)
CF58_RS06795	COG0415	Belongs to the DNA photolyase family
CF58_RS06805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CF58_RS06810	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CF58_RS06815	COG1984	allophanate hydrolase subunit 2
CF58_RS06830	COG3180	Ammonia monooxygenase
CF58_RS06835	COG3539	Fimbrial protein
CF58_RS06840	COG3121	Chaperone
CF58_RS06845	COG3188	usher protein
CF58_RS06850	COG3539	Fimbrial protein
CF58_RS06855	COG0372	Belongs to the citrate synthase family
CF58_RS06865	COG2009	succinate dehydrogenase
CF58_RS06870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CF58_RS06875	COG1053	succinate dehydrogenase
CF58_RS06880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CF58_RS06890	COG0567	Dehydrogenase, E1 component
CF58_RS06895	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF58_RS06905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF58_RS06915	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CF58_RS06920	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF58_RS06920	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF58_RS06925	COG1301	dicarboxylic acid transport
CF58_RS06935	COG4865	methylaspartate mutase activity
CF58_RS06945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF58_RS06965	COG1271	oxidase subunit
CF58_RS06970	COG1294	oxidase, subunit
CF58_RS06975	COG4890	Cyd operon protein YbgT
CF58_RS06980	COG3790	cyd operon protein YbgE
CF58_RS06985	COG0824	Thioesterase
CF58_RS06990	COG0811	peptide transport
CF58_RS06995	COG0848	biopolymer transport protein
CF58_RS07000	COG3064	Membrane
CF58_RS07010	COG2885	chlorophyll binding
CF58_RS07015	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CF58_RS07060	COG3201	nicotinamide mononucleotide transporter
CF58_RS07065	COG1230	cation diffusion facilitator family transporter
CF58_RS07080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF58_RS07090	COG2017	converts alpha-aldose to the beta-anomer
CF58_RS07100	COG1085	galactose-1-phosphate uridylyltransferase
CF58_RS07105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CF58_RS07110	COG1119	ATPase activity
CF58_RS07120	COG3585	molybdate ion transport
CF58_RS07120	COG2005	Transcriptional regulator
CF58_RS07130	COG0725	ABC transporter, periplasmic molybdate-binding protein
CF58_RS07135	COG4149	molybdate abc transporter
CF58_RS07140	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CF58_RS07145	COG0561	phosphatase activity
CF58_RS07160	COG2828	Protein conserved in bacteria
CF58_RS07165	COG0471	metal ion transport
CF58_RS07170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CF58_RS07175	COG4677	pectinesterase activity
CF58_RS07180	COG1881	PFAM PEBP family protein
CF58_RS07185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CF58_RS07200	COG2226	methyltransferase
CF58_RS07205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CF58_RS07215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CF58_RS07230	COG0521	Mo-molybdopterin cofactor biosynthetic process
CF58_RS07240	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CF58_RS07245	COG0314	molybdopterin synthase activity
CF58_RS07250	COG0670	Belongs to the BI1 family
CF58_RS07255	COG0670	Belongs to the BI1 family
CF58_RS07260	COG0392	lysyltransferase activity
CF58_RS07265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF58_RS07270	COG3568	Endonuclease Exonuclease Phosphatase
CF58_RS07280	COG0842	Transport permease protein
CF58_RS07285	COG0842	Transport permease protein
CF58_RS07290	COG1131	(ABC) transporter
CF58_RS07300	COG1309	transcriptional regulator
CF58_RS07305	COG0513	Belongs to the DEAD box helicase family
CF58_RS07320	COG1199	ATP-dependent helicase activity
CF58_RS07325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CF58_RS07330	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CF58_RS07340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CF58_RS07365	COG0668	transmembrane transport
CF58_RS07375	COG1126	abc transporter atp-binding protein
CF58_RS07380	COG0765	amino acid transport
CF58_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS07400	COG5006	permease, DMT superfamily
CF58_RS07405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CF58_RS07410	COG2194	sulfuric ester hydrolase activity
CF58_RS07420	COG1321	iron dependent repressor
CF58_RS07425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CF58_RS07430	COG1376	ErfK ybiS ycfS ynhG family protein
CF58_RS07435	COG0488	(ABC) transporter
CF58_RS07445	COG2271	Major facilitator Superfamily
CF58_RS07465	COG0561	phosphatase activity
CF58_RS07470	COG1882	Formate acetyltransferase
CF58_RS07475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF58_RS07480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF58_RS07485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CF58_RS07490	COG0303	'Molybdopterin
CF58_RS07495	COG1446	asparaginase
CF58_RS07505	COG0747	negative chemotaxis
CF58_RS07520	COG2200	EAL domain
CF58_RS07525	COG2199	diguanylate cyclase activity
CF58_RS07540	COG2133	pyrroloquinoline quinone binding
CF58_RS07545	COG0625	glutathione transferase activity
CF58_RS07550	COG1686	Belongs to the peptidase S11 family
CF58_RS07555	COG1349	DNA-binding transcription factor activity
CF58_RS07560	COG0671	phosphoesterase, PA-phosphatase related
CF58_RS07565	COG2814	Major facilitator Superfamily
CF58_RS07575	COG0561	phosphatase activity
CF58_RS07580	COG0738	Major facilitator superfamily
CF58_RS07585	COG3226	Transcriptional regulator
CF58_RS07600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF58_RS07610	COG0778	Nitroreductase
CF58_RS07630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF58_RS07635	COG3842	ATPase activity
CF58_RS07640	COG1176	ABC-type spermidine putrescine transport system, permease component I
CF58_RS07645	COG1177	transmembrane transport
CF58_RS07660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS07665	COG4160	amino acid transport
CF58_RS07670	COG4215	(ABC) transporter
CF58_RS07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS07680	COG1126	abc transporter atp-binding protein
CF58_RS07710	COG3023	N-Acetylmuramoyl-L-alanine amidase
CF58_RS07715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF58_RS07720	COG0702	epimerase
CF58_RS07725	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CF58_RS07730	COG0028	Belongs to the TPP enzyme family
CF58_RS07735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF58_RS07745	COG2431	L-lysine efflux transmembrane transporter activity
CF58_RS07750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CF58_RS07760	COG3593	DNA synthesis involved in DNA repair
CF58_RS07765	COG2990	Protein conserved in bacteria
CF58_RS07770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF58_RS07775	COG0577	efflux transmembrane transporter activity
CF58_RS07775	COG1136	(ABC) transporter
CF58_RS07780	COG1278	Cold shock
CF58_RS07790	COG0542	response to heat
CF58_RS07810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CF58_RS07815	COG4988	ABC transporter
CF58_RS07820	COG0492	ferredoxin-NADP+ reductase activity
CF58_RS07825	COG1522	sequence-specific DNA binding
CF58_RS07830	COG1178	ABC-type Fe3 transport system permease component
CF58_RS07830	COG1674	ftsk spoiiie
CF58_RS07840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CF58_RS07850	COG0243	molybdopterin cofactor binding
CF58_RS07855	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS07860	COG3302	dmso reductase anchor subunit
CF58_RS07865	COG1335	isochorismatase
CF58_RS07875	COG0531	amino acid
CF58_RS07880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF58_RS07885	COG1882	Formate acetyltransferase
CF58_RS07890	COG2116	formate transmembrane transporter activity
CF58_RS07895	COG1944	ATP diphosphatase activity
CF58_RS07900	COG2323	membrane
CF58_RS07920	COG0501	Belongs to the peptidase M48B family
CF58_RS07930	COG0539	negative regulation of cytoplasmic translation
CF58_RS07955	COG3214	Protein conserved in bacteria
CF58_RS07970	COG3173	Aminoglycoside phosphotransferase
CF58_RS07975	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CF58_RS07980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CF58_RS07990	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CF58_RS08000	COG2989	Protein conserved in bacteria
CF58_RS08005	COG3108	Peptidase M15
CF58_RS08010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CF58_RS08015	COG1448	Aminotransferase
CF58_RS08040	COG0308	aminopeptidase N
CF58_RS08045	COG2801	Transposase and inactivated derivatives
CF58_RS08065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CF58_RS08075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CF58_RS08080	COG0431	NADPH-dependent FMN reductase
CF58_RS08095	COG3217	Mosc domain protein beta barrel domain protein
CF58_RS08095	COG0633	Ferredoxin
CF58_RS08105	COG0488	(ABC) transporter
CF58_RS08110	COG2995	paraquat-inducible protein a
CF58_RS08115	COG3008	intermembrane lipid transfer
CF58_RS08115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CF58_RS08120	COG3009	Protein conserved in bacteria
CF58_RS08125	COG3130	regulation of translation
CF58_RS08135	COG1067	ATP-dependent peptidase activity
CF58_RS08160	COG3070	regulator of competence-specific genes
CF58_RS08165	COG1289	transmembrane transporter activity
CF58_RS08170	COG3304	Inner membrane component domain
CF58_RS08175	COG0210	DNA helicase
CF58_RS08195	COG1832	CoA-binding protein
CF58_RS08210	COG1254	Belongs to the acylphosphatase family
CF58_RS08215	COG2920	part of a sulfur-relay system
CF58_RS08220	COG0670	Belongs to the BI1 family
CF58_RS08230	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CF58_RS08235	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CF58_RS08240	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CF58_RS08245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF58_RS08250	COG1999	signal sequence binding
CF58_RS08255	COG1773	rubredoxin
CF58_RS08260	COG1271	oxidase subunit
CF58_RS08265	COG1294	oxidase, subunit
CF58_RS08280	COG1278	Cold shock
CF58_RS08285	COG1278	Cold shock
CF58_RS08300	COG0348	domain, Protein
CF58_RS08305	COG2205	protein histidine kinase activity
CF58_RS08305	COG0784	Response regulator, receiver
CF58_RS08305	COG2198	Histidine kinase
CF58_RS08310	COG1879	ABC-type sugar transport system periplasmic component
CF58_RS08315	COG0745	RESPONSE REGULATOR receiver
CF58_RS08320	COG3005	denitrification pathway
CF58_RS08325	COG0243	molybdopterin cofactor binding
CF58_RS08330	COG3381	protein complex oligomerization
CF58_RS08370	COG3729	General stress protein
CF58_RS08375	COG2233	PERMEase
CF58_RS08410	COG1309	transcriptional regulator
CF58_RS08415	COG0506	proline dehydrogenase activity
CF58_RS08415	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF58_RS08415	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF58_RS08425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF58_RS08450	COG1702	phosphate starvation-inducible protein PhoH
CF58_RS08470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CF58_RS08480	COG3381	protein complex oligomerization
CF58_RS08490	COG1462	curli production assembly transport component CsgG
CF58_RS08505	COG2197	response regulator
CF58_RS08535	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF58_RS08540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF58_RS08565	COG2943	transferase activity, transferring hexosyl groups
CF58_RS08570	COG5645	(Lipo)protein
CF58_RS08590	COG1560	Kdo2-lipid A biosynthetic process
CF58_RS08600	COG2353	YceI-like domain
CF58_RS08605	COG3038	cytochrome b561
CF58_RS08640	COG2999	glutathione oxidoreductase activity
CF58_RS08650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF58_RS08660	COG0673	inositol 2-dehydrogenase activity
CF58_RS08665	COG0728	peptidoglycan biosynthetic process
CF58_RS08670	COG3418	PFAM FlgN family protein
CF58_RS08675	COG2747	anti-sigma28 factor FlgM
CF58_RS08680	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CF58_RS08685	COG1815	bacterial-type flagellum-dependent cell motility
CF58_RS08690	COG1558	bacterial-type flagellum-dependent cell motility
CF58_RS08695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CF58_RS08700	COG1749	Flagellar hook protein flgE
CF58_RS08705	COG4787	bacterial-type flagellum-dependent cell motility
CF58_RS08710	COG4786	Flagellar basal body rod
CF58_RS08725	COG3951	Flagellar rod assembly protein muramidase FlgJ
CF58_RS08725	COG1705	Flagellar rod assembly protein muramidase FlgJ
CF58_RS08730	COG1256	bacterial-type flagellum assembly
CF58_RS08735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CF58_RS08740	COG1530	ribonuclease E activity
CF58_RS08750	COG0564	pseudouridine synthase activity
CF58_RS08755	COG0424	maF-like protein
CF58_RS08760	COG1399	metal-binding, possibly nucleic acid-binding protein
CF58_RS08780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CF58_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS08795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF58_RS08800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CF58_RS08805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CF58_RS08815	COG0470	DNA polymerase III
CF58_RS08820	COG0084	hydrolase, TatD family'
CF58_RS08825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS08825	COG1263	PTS System
CF58_RS08830	COG4773	Receptor
CF58_RS08835	COG0537	adenosine 5'-monophosphoramidase activity
CF58_RS08840	COG5633	Lipoprotein
CF58_RS08845	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CF58_RS08865	COG1252	NADH dehydrogenase
CF58_RS08870	COG3134	Outer membrane lipoprotein
CF58_RS08875	COG1309	transcriptional regulator
CF58_RS08885	COG1388	LysM domain
CF58_RS08885	COG1376	ErfK ybiS ycfS ynhG family protein
CF58_RS08890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CF58_RS08895	COG4763	Acyl-transferase
CF58_RS08900	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF58_RS08910	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF58_RS08920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CF58_RS08925	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CF58_RS08935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF58_RS08940	COG1177	transmembrane transport
CF58_RS08950	COG3842	ATPase activity
CF58_RS08965	COG2850	peptidyl-arginine hydroxylation
CF58_RS08970	COG2205	protein histidine kinase activity
CF58_RS08980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CF58_RS09000	COG1187	pseudouridine synthase activity
CF58_RS09005	COG0538	isocitrate dehydrogenase activity
CF58_RS09020	COG5562	phage envelope protein
CF58_RS09025	COG0789	Transcriptional regulator
CF58_RS09030	COG2200	EAL domain
CF58_RS09055	COG2200	EAL domain
CF58_RS09090	COG3468	outer membrane autotransporter barrel domain protein
CF58_RS09100	COG2894	cell division
CF58_RS09130	COG0179	Fumarylacetoacetate (FAA) hydrolase
CF58_RS09145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CF58_RS09150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CF58_RS09155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CF58_RS09175	COG2719	SpoVR family
CF58_RS09185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CF58_RS09200	COG1619	proteins homologs of microcin C7 resistance protein MccF
CF58_RS09210	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CF58_RS09225	COG0157	Belongs to the NadC ModD family
CF58_RS09230	COG0500	methyltransferase
CF58_RS09235	COG1120	ATPase activity
CF58_RS09240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF58_RS09245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF58_RS09255	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CF58_RS09255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS09255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF58_RS09260	COG1461	Dihydroxyacetone kinase
CF58_RS09265	COG2376	Dihydroxyacetone kinase
CF58_RS09270	COG3284	Transcriptional regulator
CF58_RS09275	COG3468	outer membrane autotransporter barrel domain protein
CF58_RS09285	COG0012	GTP binding
CF58_RS09300	COG0659	secondary active sulfate transmembrane transporter activity
CF58_RS09305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CF58_RS09330	COG2890	protein-(glutamine-N5) methyltransferase activity
CF58_RS09335	COG3094	Invasion gene expression up-regulator, SirB
CF58_RS09340	COG2912	Transglutaminase-like superfamily
CF58_RS09360	COG0387	Pfam Sodium calcium exchanger
CF58_RS09365	COG4572	Cation transport regulator
CF58_RS09370	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CF58_RS09375	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CF58_RS09380	COG4932	domain protein
CF58_RS09385	COG2197	response regulator
CF58_RS09390	COG3850	Histidine kinase
CF58_RS09400	COG2223	nitrite transmembrane transporter activity
CF58_RS09405	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CF58_RS09410	COG1140	nitrate reductase beta subunit
CF58_RS09415	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CF58_RS09420	COG2181	nitrate reductase activity
CF58_RS09435	COG0788	formyltetrahydrofolate deformylase activity
CF58_RS09445	COG1752	Esterase of the alpha-beta hydrolase superfamily
CF58_RS09450	COG0745	RESPONSE REGULATOR receiver
CF58_RS09455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CF58_RS09465	COG1435	thymidine kinase activity
CF58_RS09470	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS09470	COG1454	alcohol dehydrogenase
CF58_RS09475	COG2095	MarC family integral membrane protein
CF58_RS09480	COG4166	transmembrane transport
CF58_RS09485	COG0601	transmembrane transport
CF58_RS09490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF58_RS09495	COG0444	Belongs to the ABC transporter superfamily
CF58_RS09500	COG4608	Belongs to the ABC transporter superfamily
CF58_RS09525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CF58_RS09530	COG2350	Protein conserved in bacteria
CF58_RS09535	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CF58_RS09540	COG1607	acyl-coa hydrolase
CF58_RS09555	COG3047	cAMP biosynthetic process
CF58_RS09560	COG3685	Protein conserved in bacteria
CF58_RS09570	COG3729	General stress protein
CF58_RS09575	COG0159	tryptophan synthase activity
CF58_RS09585	COG0134	indole-3-glycerol-phosphate synthase activity
CF58_RS09585	COG0135	phosphoribosylanthranilate isomerase activity
CF58_RS09590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CF58_RS09590	COG0512	Glutamine amidotransferase of anthranilate synthase
CF58_RS09595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CF58_RS09600	COG0613	PHP domain protein
CF58_RS09605	COG0009	L-threonylcarbamoyladenylate synthase
CF58_RS09615	COG1187	pseudouridine synthase activity
CF58_RS09630	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CF58_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS09645	COG0616	signal peptide processing
CF58_RS09660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CF58_RS09665	COG0583	DNA-binding transcription factor activity
CF58_RS09690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CF58_RS09700	COG0671	phosphoesterase, PA-phosphatase related
CF58_RS09705	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CF58_RS09710	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CF58_RS09720	COG0023	Translation Initiation Factor
CF58_RS09730	COG1349	DNA-binding transcription factor activity
CF58_RS09740	COG5001	Diguanylate cyclase
CF58_RS09755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF58_RS09755	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF58_RS09760	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CF58_RS09770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF58_RS09775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF58_RS09785	COG2814	Major facilitator Superfamily
CF58_RS09790	COG4172	Belongs to the ABC transporter superfamily
CF58_RS09795	COG4172	Belongs to the ABC transporter superfamily
CF58_RS09800	COG4171	peptide transport system, permease
CF58_RS09805	COG4168	peptide transport system, permease
CF58_RS09810	COG4166	transmembrane transport
CF58_RS09825	COG0531	amino acid
CF58_RS09830	COG0174	glutamine synthetase
CF58_RS09835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CF58_RS09840	COG1917	Cupin 2, conserved barrel domain protein
CF58_RS09840	COG1396	sequence-specific DNA binding
CF58_RS09845	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS09850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CF58_RS09855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CF58_RS09860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CF58_RS09865	COG1842	Phage shock protein A
CF58_RS09875	COG1983	PspC domain protein
CF58_RS09885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF58_RS09890	COG3106	COG3106 Predicted ATPase
CF58_RS09900	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CF58_RS09905	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CF58_RS09910	COG4948	Mandelate Racemase Muconate Lactonizing
CF58_RS09915	COG2866	Carboxypeptidase
CF58_RS09920	COG0702	epimerase
CF58_RS09925	COG1073	alpha beta
CF58_RS09930	COG0583	DNA-binding transcription factor activity
CF58_RS09940	COG4166	transmembrane transport
CF58_RS09945	COG0668	transmembrane transport
CF58_RS09950	COG3182	Iron-regulated membrane protein
CF58_RS09955	COG0589	response to stress
CF58_RS09960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF58_RS09965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CF58_RS09970	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CF58_RS09980	COG1473	amidohydrolase
CF58_RS09985	COG1473	amidohydrolase
CF58_RS09990	COG0583	DNA-binding transcription factor activity
CF58_RS10000	COG2207	Transcriptional regulator
CF58_RS10015	COG2840	Smr protein MutS2
CF58_RS10020	COG3706	GGDEF domain
CF58_RS10035	COG0513	Belongs to the DEAD box helicase family
CF58_RS10045	COG0582	viral genome integration into host DNA
CF58_RS10070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF58_RS10100	COG4197	protein conserved in bacteria, prophage-related
CF58_RS10110	COG3756	Protein conserved in bacteria
CF58_RS10115	COG1484	DNA-dependent DNA replication
CF58_RS10120	COG1846	Transcriptional regulator
CF58_RS10175	COG3064	Membrane
CF58_RS10190	COG3772	lysozyme
CF58_RS10200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CF58_RS10205	COG1475	DNA binding
CF58_RS10285	COG1196	nuclear chromosome segregation
CF58_RS10360	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF58_RS10360	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF58_RS10375	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF58_RS10375	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF58_RS10380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF58_RS10485	COG2207	Transcriptional regulator
CF58_RS10505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CF58_RS10700	COG0305	Participates in initiation and elongation during chromosome replication
CF58_RS10735	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CF58_RS10910	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF58_RS10930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF58_RS10940	COG0589	response to stress
CF58_RS10945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF58_RS10950	COG0674	pyruvate-flavodoxin oxidoreductase activity
CF58_RS10950	COG1013	pyruvate-flavodoxin oxidoreductase activity
CF58_RS10950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CF58_RS10950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF58_RS10955	COG3042	response to heat
CF58_RS10960	COG3187	Heat shock protein
CF58_RS10965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CF58_RS10970	COG2911	Protein conserved in bacteria
CF58_RS10980	COG3784	Protein of unknown function (DUF1318)
CF58_RS10985	COG2207	Transcriptional regulator
CF58_RS10990	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS10995	COG3733	amine oxidase
CF58_RS11000	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS11000	COG2030	dehydratase
CF58_RS11005	COG3396	Phenylacetate-CoA oxygenase
CF58_RS11010	COG3460	Phenylacetate-CoA oxygenase
CF58_RS11015	COG3396	Phenylacetate-CoA oxygenase
CF58_RS11020	COG2151	metal-sulfur cluster biosynthetic enzyme
CF58_RS11025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF58_RS11030	COG1024	Enoyl-CoA hydratase
CF58_RS11035	COG1024	Enoyl-CoA hydratase
CF58_RS11040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CF58_RS11045	COG2050	protein possibly involved in aromatic compounds catabolism
CF58_RS11050	COG0183	Belongs to the thiolase family
CF58_RS11055	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CF58_RS11060	COG3327	negative regulation of DNA-templated transcription, initiation
CF58_RS11065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF58_RS11075	COG0667	Aldo Keto reductase
CF58_RS11085	COG1643	Atp-dependent helicase
CF58_RS11090	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CF58_RS11095	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS11100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CF58_RS11105	COG3038	cytochrome b561
CF58_RS11120	COG2801	Transposase and inactivated derivatives
CF58_RS11125	COG2963	transposase activity
CF58_RS11130	COG0840	transmembrane signaling receptor activity
CF58_RS11135	COG0583	DNA-binding transcription factor activity
CF58_RS11140	COG5383	Protein conserved in bacteria
CF58_RS11155	COG2841	Protein conserved in bacteria
CF58_RS11160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF58_RS11165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF58_RS11170	COG1275	C4-dicarboxylate transporter malic acid transport protein
CF58_RS11175	COG0500	methyltransferase
CF58_RS11185	COG3135	benzoate transporter
CF58_RS11190	COG1396	sequence-specific DNA binding
CF58_RS11195	COG0826	peptidase U32
CF58_RS11205	COG1724	mRNA binding
CF58_RS11210	COG1598	PFAM Uncharacterised protein family UPF0150
CF58_RS11215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF58_RS11220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF58_RS11225	COG3842	ATPase activity
CF58_RS11230	COG1176	ABC-type spermidine putrescine transport system, permease component I
CF58_RS11235	COG1177	transmembrane transport
CF58_RS11260	COG3238	Protein conserved in bacteria
CF58_RS11265	COG1247	-acetyltransferase
CF58_RS11270	COG2130	NADP-dependent
CF58_RS11275	COG1802	Transcriptional regulator
CF58_RS11280	COG4772	TonB-dependent receptor
CF58_RS11285	COG3391	amine dehydrogenase activity
CF58_RS11290	COG1113	amino acid transport
CF58_RS11310	COG3209	COG3209 Rhs family protein
CF58_RS11320	COG5433	transposase activity
CF58_RS11325	COG2203	Gaf domain
CF58_RS11325	COG3706	GGDEF domain
CF58_RS11325	COG4251	negative regulation of phosphorylation
CF58_RS11325	COG5001	Diguanylate cyclase
CF58_RS11330	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CF58_RS11340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CF58_RS11345	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CF58_RS11350	COG0384	phenazine biosynthesis protein PhzF
CF58_RS11355	COG2181	nitrate reductase activity
CF58_RS11360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CF58_RS11365	COG1140	nitrate reductase beta subunit
CF58_RS11370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CF58_RS11375	COG2223	nitrite transmembrane transporter activity
CF58_RS11380	COG4886	Leucine-rich repeat (LRR) protein
CF58_RS11385	COG4886	Leucine-rich repeat (LRR) protein
CF58_RS11395	COG0697	spore germination
CF58_RS11400	COG0243	molybdopterin cofactor binding
CF58_RS11400	COG3383	formate dehydrogenase (NAD+) activity
CF58_RS11405	COG3383	formate dehydrogenase (NAD+) activity
CF58_RS11405	COG0243	molybdopterin cofactor binding
CF58_RS11410	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS11415	COG2864	formate dehydrogenase
CF58_RS11430	COG3093	addiction module antidote protein HigA
CF58_RS11435	COG1064	alcohol dehydrogenase
CF58_RS11455	COG1764	response to oxidative stress
CF58_RS11460	COG4608	Belongs to the ABC transporter superfamily
CF58_RS11465	COG0444	Belongs to the ABC transporter superfamily
CF58_RS11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF58_RS11475	COG0601	transmembrane transport
CF58_RS11480	COG0747	negative chemotaxis
CF58_RS11485	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CF58_RS11490	COG2200	EAL domain
CF58_RS11490	COG2202	Pas domain
CF58_RS11490	COG2199	diguanylate cyclase activity
CF58_RS11500	COG1649	PFAM Uncharacterised BCR, COG1649
CF58_RS11505	COG0531	amino acid
CF58_RS11510	COG0076	glutamate decarboxylase activity
CF58_RS11520	COG0612	Peptidase, M16
CF58_RS11525	COG4771	TonB-dependent receptor
CF58_RS11530	COG4178	(ABC) transporter
CF58_RS11535	COG0641	radical SAM
CF58_RS11540	COG3119	arylsulfatase activity
CF58_RS11555	COG0243	molybdopterin cofactor binding
CF58_RS11560	COG3539	Fimbrial protein
CF58_RS11565	COG3539	Fimbrial protein
CF58_RS11570	COG3539	Fimbrial protein
CF58_RS11575	COG3188	usher protein
CF58_RS11585	COG3539	Fimbrial protein
CF58_RS11590	COG4977	sequence-specific DNA binding
CF58_RS11605	COG0667	Aldo Keto reductase
CF58_RS11625	COG3550	peptidyl-serine autophosphorylation
CF58_RS11630	COG1396	sequence-specific DNA binding
CF58_RS11635	COG3210	domain, Protein
CF58_RS11635	COG2911	Protein conserved in bacteria
CF58_RS11685	COG3781	membrane
CF58_RS11700	COG2199	diguanylate cyclase activity
CF58_RS11710	COG2066	Belongs to the glutaminase family
CF58_RS11715	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS11720	COG0583	DNA-binding transcription factor activity
CF58_RS11740	COG1846	Transcriptional regulator
CF58_RS11745	COG4977	sequence-specific DNA binding
CF58_RS11755	COG2723	6-phospho-beta-galactosidase activity
CF58_RS11765	COG1447	Phosphotransferase system cellobiose-specific component IIA
CF58_RS11770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF58_RS11780	COG2188	Transcriptional regulator
CF58_RS11785	COG0697	spore germination
CF58_RS11790	COG2814	Major facilitator Superfamily
CF58_RS11800	COG3706	GGDEF domain
CF58_RS11805	COG3111	PFAM Bacterial OB fold (BOF) protein
CF58_RS11815	COG0339	signal peptide processing
CF58_RS11820	COG4221	oxidoreductase activity
CF58_RS11825	COG1802	Transcriptional regulator
CF58_RS11835	COG0246	Mannitol dehydrogenase
CF58_RS11840	COG0477	Major facilitator Superfamily
CF58_RS11845	COG1063	alcohol dehydrogenase
CF58_RS11850	COG4948	Mandelate Racemase Muconate Lactonizing
CF58_RS11865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF58_RS11880	COG0243	molybdopterin cofactor binding
CF58_RS11885	COG0243	molybdopterin cofactor binding
CF58_RS11890	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS11895	COG3302	dmso reductase anchor subunit
CF58_RS11900	COG3381	protein complex oligomerization
CF58_RS11910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CF58_RS11915	COG1940	carbohydrate kinase activity
CF58_RS11920	COG0583	DNA-binding transcription factor activity
CF58_RS11925	COG2814	Major facilitator Superfamily
CF58_RS11940	COG3591	Belongs to the peptidase S1B family
CF58_RS11955	COG0628	permease
CF58_RS11960	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CF58_RS11965	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CF58_RS11975	COG0531	amino acid
CF58_RS11985	COG3136	membrane protein required for alginate biosynthesis
CF58_RS11990	COG0745	RESPONSE REGULATOR receiver
CF58_RS11995	COG2205	protein histidine kinase activity
CF58_RS12005	COG0114	fumarate hydratase activity
CF58_RS12010	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF58_RS12010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF58_RS12015	COG1482	cell wall glycoprotein biosynthetic process
CF58_RS12020	COG5339	Protein conserved in bacteria
CF58_RS12035	COG3250	beta-galactosidase activity
CF58_RS12040	COG1309	transcriptional regulator
CF58_RS12045	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS12050	COG1609	Transcriptional regulator
CF58_RS12055	COG1263	PTS System
CF58_RS12055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS12060	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CF58_RS12070	COG0673	inositol 2-dehydrogenase activity
CF58_RS12105	COG4658	electron transport chain
CF58_RS12110	COG4659	FMN binding
CF58_RS12120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CF58_RS12130	COG3104	oligopeptide transport
CF58_RS12135	COG0625	glutathione transferase activity
CF58_RS12140	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CF58_RS12155	COG3895	Periplasmic Protein
CF58_RS12165	COG3133	Outer membrane lipoprotein
CF58_RS12180	COG1566	PFAM secretion protein HlyD family protein
CF58_RS12185	COG1289	transmembrane transporter activity
CF58_RS12190	COG2032	superoxide dismutase activity
CF58_RS12195	COG4989	oxidoreductase activity
CF58_RS12200	COG3313	Fe-S protein
CF58_RS12205	COG1309	transcriptional regulator
CF58_RS12210	COG1902	pentaerythritol trinitrate reductase activity
CF58_RS12215	COG0346	lactoylglutathione lyase activity
CF58_RS12225	COG1201	RNA secondary structure unwinding
CF58_RS12230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CF58_RS12235	COG0791	NLP P60 protein
CF58_RS12240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CF58_RS12245	COG2814	Major facilitator Superfamily
CF58_RS12260	COG0583	DNA-binding transcription factor activity
CF58_RS12265	COG2814	Major facilitator Superfamily
CF58_RS12270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CF58_RS12275	COG0307	riboflavin synthase, alpha
CF58_RS12285	COG3468	outer membrane autotransporter barrel domain protein
CF58_RS12305	COG4529	Protein conserved in bacteria
CF58_RS12315	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CF58_RS12320	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS12330	COG2414	aldehyde ferredoxin oxidoreductase
CF58_RS12335	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS12345	COG0469	pyruvate kinase activity
CF58_RS12350	COG4238	major outer membrane lipoprotein
CF58_RS12355	COG1376	ErfK ybiS ycfS ynhG family protein
CF58_RS12370	COG0719	Fe-S assembly protein
CF58_RS12375	COG0396	ATPase activity
CF58_RS12380	COG0719	Fe-S assembly protein
CF58_RS12385	COG0316	Belongs to the HesB IscA family
CF58_RS12395	COG2050	protein possibly involved in aromatic compounds catabolism
CF58_RS12400	COG0277	FAD linked oxidase domain protein
CF58_RS12400	COG0247	lactate metabolic process
CF58_RS12405	COG0628	permease
CF58_RS12415	COG0738	Major facilitator superfamily
CF58_RS12420	COG2271	Major facilitator Superfamily
CF58_RS12435	COG4670	ketone body catabolic process
CF58_RS12440	COG1960	acyl-CoA dehydrogenase activity
CF58_RS12445	COG2207	Transcriptional regulator
CF58_RS12445	COG1917	Cupin 2, conserved barrel domain protein
CF58_RS12455	COG2086	electron transfer activity
CF58_RS12460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CF58_RS12465	COG0644	oxidoreductase
CF58_RS12470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF58_RS12475	COG0318	PFAM AMP-dependent synthetase and ligase
CF58_RS12480	COG0574	Belongs to the PEP-utilizing enzyme family
CF58_RS12480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF58_RS12495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF58_RS12500	COG4256	Hemin uptake protein
CF58_RS12510	COG2200	EAL domain
CF58_RS12515	COG0791	NLP P60 protein
CF58_RS12525	COG0386	Belongs to the glutathione peroxidase family
CF58_RS12580	COG3137	Salt-induced outer membrane protein
CF58_RS12585	COG1105	Belongs to the carbohydrate kinase PfkB family
CF58_RS12595	COG3001	Fructosamine kinase
CF58_RS12605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF58_RS12610	COG1988	membrane-bound metal-dependent
CF58_RS12615	COG1823	symporter activity
CF58_RS12630	COG0753	catalase activity
CF58_RS12640	COG1486	melibiose metabolic process
CF58_RS12645	COG2169	Transcriptional regulator
CF58_RS12645	COG1917	Cupin 2, conserved barrel domain protein
CF58_RS12650	COG1447	Phosphotransferase system cellobiose-specific component IIA
CF58_RS12655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF58_RS12660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF58_RS12665	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF58_RS12680	COG0322	excinuclease ABC activity
CF58_RS12690	COG3678	ATP-independent chaperone mediated protein folding
CF58_RS12720	COG0708	Exodeoxyribonuclease III
CF58_RS12725	COG0398	Pfam SNARE associated Golgi protein
CF58_RS12735	COG0398	Pfam SNARE associated Golgi protein
CF58_RS12740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF58_RS12750	COG4135	transport system, permease component
CF58_RS12755	COG4136	ATPase activity
CF58_RS12760	COG2897	thiosulfate sulfurtransferase activity
CF58_RS12765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CF58_RS12770	COG0494	nUDIX hydrolase
CF58_RS12780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CF58_RS12790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CF58_RS12795	COG0709	Synthesizes selenophosphate from selenide and ATP
CF58_RS12805	COG0778	Nitroreductase
CF58_RS12815	COG0616	signal peptide processing
CF58_RS12820	COG0252	asparaginase activity
CF58_RS12825	COG1335	isochorismatase
CF58_RS12830	COG2814	Major facilitator Superfamily
CF58_RS12835	COG1349	DNA-binding transcription factor activity
CF58_RS12840	COG0667	Aldo Keto reductase
CF58_RS12845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF58_RS12850	COG0191	fructose-bisphosphate aldolase activity
CF58_RS12855	COG1063	alcohol dehydrogenase
CF58_RS12860	COG2271	Major facilitator Superfamily
CF58_RS12865	COG1063	alcohol dehydrogenase
CF58_RS12870	COG3139	Protein of unknown function (DUF1315)
CF58_RS12880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CF58_RS12885	COG0676	glucose-6-phosphate 1-epimerase activity
CF58_RS12890	COG0656	L-ascorbic acid biosynthetic process
CF58_RS12895	COG3713	MltA-interacting MipA family protein
CF58_RS12900	COG2766	serine protein kinase
CF58_RS12910	COG2199	diguanylate cyclase activity
CF58_RS12915	COG2199	diguanylate cyclase activity
CF58_RS12920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CF58_RS12935	COG2207	Transcriptional regulator
CF58_RS12940	COG2807	transmembrane transport
CF58_RS12945	COG3189	MarR family transcriptional regulator
CF58_RS12950	COG3042	response to heat
CF58_RS12955	COG2199	diguanylate cyclase activity
CF58_RS12955	COG2203	Gaf domain
CF58_RS12965	COG2261	transglycosylase associated protein
CF58_RS12975	COG3615	Tellurite resistance protein tehB
CF58_RS12990	COG0473	3-isopropylmalate dehydrogenase activity
CF58_RS12995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CF58_RS13000	COG4638	Rieske (2fe-2S)
CF58_RS13005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF58_RS13010	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CF58_RS13015	COG0318	PFAM AMP-dependent synthetase and ligase
CF58_RS13020	COG3065	identical protein binding
CF58_RS13025	COG1214	PFAM Peptidase M22, glycoprotease
CF58_RS13030	COG1199	ATP-dependent helicase activity
CF58_RS13035	COG0251	oxidation-reduction process
CF58_RS13055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CF58_RS13060	COG0494	nUDIX hydrolase
CF58_RS13065	COG1760	l-serine dehydratase
CF58_RS13070	COG2200	EAL domain
CF58_RS13075	COG1253	flavin adenine dinucleotide binding
CF58_RS13085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS13085	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS13090	COG3715	PTS system
CF58_RS13095	COG3716	PTS system mannose fructose sorbose family IID component
CF58_RS13115	COG2226	methyltransferase
CF58_RS13150	COG1414	Transcriptional regulator
CF58_RS13155	COG2814	Major facilitator Superfamily
CF58_RS13165	COG0793	Belongs to the peptidase S41A family
CF58_RS13175	COG1956	GAF domain-containing protein
CF58_RS13180	COG2995	paraquat-inducible protein a
CF58_RS13185	COG3008	intermembrane lipid transfer
CF58_RS13205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CF58_RS13220	COG1276	copper resistance
CF58_RS13225	COG2372	response to copper ion
CF58_RS13235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF58_RS13240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF58_RS13245	COG1770	oligopeptidase
CF58_RS13260	COG2979	Protein of unknown function (DUF533)
CF58_RS13275	COG3141	response to X-ray
CF58_RS13285	COG0800	Aldolase
CF58_RS13290	COG0129	dihydroxy-acid dehydratase activity
CF58_RS13295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CF58_RS13305	COG1737	Transcriptional regulator
CF58_RS13310	COG0469	pyruvate kinase activity
CF58_RS13320	COG1560	Kdo2-lipid A biosynthetic process
CF58_RS13325	COG0739	heme binding
CF58_RS13330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CF58_RS13340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CF58_RS13365	COG0217	transcriptional regulatory protein
CF58_RS13370	COG0494	nUDIX hydrolase
CF58_RS13380	COG1335	isochorismatase
CF58_RS13385	COG1801	Protein of unknown function DUF72
CF58_RS13390	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CF58_RS13405	COG0243	molybdopterin cofactor binding
CF58_RS13410	COG3005	denitrification pathway
CF58_RS13420	COG3102	Protein conserved in bacteria
CF58_RS13435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CF58_RS13440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CF58_RS13445	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CF58_RS13450	COG0745	RESPONSE REGULATOR receiver
CF58_RS13460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CF58_RS13465	COG0840	transmembrane signaling receptor activity
CF58_RS13470	COG0840	transmembrane signaling receptor activity
CF58_RS13475	COG0835	chemotaxis
CF58_RS13480	COG0643	Histidine kinase
CF58_RS13480	COG2198	Histidine kinase
CF58_RS13485	COG1360	Flagellar Motor Protein
CF58_RS13490	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CF58_RS13505	COG0589	response to stress
CF58_RS13515	COG1877	trehalose-phosphatase activity
CF58_RS13520	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF58_RS13525	COG1129	ABC transporter
CF58_RS13530	COG1879	ABC-type sugar transport system periplasmic component
CF58_RS13535	COG1528	Iron-storage protein
CF58_RS13555	COG1528	Iron-storage protein
CF58_RS13565	COG0814	amino acid
CF58_RS13570	COG3012	SEC-C Motif Domain Protein
CF58_RS13570	COG3318	Belongs to the UPF0149 family
CF58_RS13600	COG2197	response regulator
CF58_RS13615	COG2197	response regulator
CF58_RS13620	COG1126	abc transporter atp-binding protein
CF58_RS13625	COG0765	amino acid transport
CF58_RS13635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS13645	COG1191	sigma factor activity
CF58_RS13655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CF58_RS13660	COG1516	flagellar protein fliS
CF58_RS13670	COG0366	Alpha amylase catalytic
CF58_RS13680	COG2391	methyltransferase activity
CF58_RS13685	COG0425	Belongs to the sulfur carrier protein TusA family
CF58_RS13690	COG2135	peptidase activity
CF58_RS13695	COG0454	-acetyltransferase
CF58_RS13720	COG1766	The M ring may be actively involved in energy transduction
CF58_RS13725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF58_RS13730	COG1317	bacterial-type flagellum organization
CF58_RS13735	COG1157	protein secretion by the type III secretion system
CF58_RS13740	COG2882	bacterial-type flagellum organization
CF58_RS13745	COG3144	bacterial-type flagellum assembly
CF58_RS13750	COG1580	Controls the rotational direction of flagella during chemotaxis
CF58_RS13755	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF58_RS13760	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF58_RS13765	COG3190	flagellar
CF58_RS13770	COG1338	Plays a role in the flagellum-specific transport system
CF58_RS13775	COG1987	bacterial-type flagellum assembly
CF58_RS13780	COG1684	flagellar biosynthetic protein fliR
CF58_RS13785	COG2197	response regulator
CF58_RS13810	COG5475	Uncharacterized small protein (DUF2158)
CF58_RS13815	COG2354	Protein conserved in bacteria
CF58_RS13820	COG0697	spore germination
CF58_RS13825	COG3727	T/G mismatch-specific endonuclease activity
CF58_RS13830	COG0270	DNA (cytosine-5-)-methyltransferase activity
CF58_RS13835	COG1418	mRNA catabolic process
CF58_RS13845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF58_RS13860	COG2205	protein histidine kinase activity
CF58_RS13865	COG0745	RESPONSE REGULATOR receiver
CF58_RS13870	COG2351	hydroxyisourate hydrolase activity
CF58_RS13885	COG3443	Belongs to the bacterial solute-binding protein 9 family
CF58_RS13910	COG1388	LysM domain
CF58_RS13910	COG4932	domain protein
CF58_RS13910	COG2373	Large extracellular alpha-helical protein
CF58_RS13920	COG0477	Major facilitator Superfamily
CF58_RS13925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CF58_RS13930	COG0217	transcriptional regulatory protein
CF58_RS13940	COG3209	COG3209 Rhs family protein
CF58_RS13950	COG3423	Transcriptional regulator
CF58_RS13975	COG0534	Mate efflux family protein
CF58_RS13985	COG0583	DNA-binding transcription factor activity
CF58_RS13990	COG0583	DNA-binding transcription factor activity
CF58_RS14000	COG1376	ErfK ybiS ycfS ynhG family protein
CF58_RS14015	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CF58_RS14035	COG1289	transmembrane transporter activity
CF58_RS14045	COG1686	Belongs to the peptidase S11 family
CF58_RS14050	COG2925	Exonuclease
CF58_RS14055	COG0531	amino acid
CF58_RS14060	COG0583	DNA-binding transcription factor activity
CF58_RS14065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF58_RS14070	COG4115	mRNA cleavage
CF58_RS14075	COG2161	toxin-antitoxin pair type II binding
CF58_RS14085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CF58_RS14095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CF58_RS14095	COG0131	Imidazoleglycerol-phosphate dehydratase
CF58_RS14100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CF58_RS14125	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF58_RS14135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CF58_RS14160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF58_RS14165	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CF58_RS14195	COG2244	polysaccharide biosynthetic process
CF58_RS14205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CF58_RS14210	COG1091	dTDP-4-dehydrorhamnose reductase activity
CF58_RS14215	COG1088	dTDP-glucose 4,6-dehydratase activity
CF58_RS14220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CF58_RS14230	COG0438	transferase activity, transferring glycosyl groups
CF58_RS14235	COG2327	Polysaccharide pyruvyl transferase
CF58_RS14240	COG2244	polysaccharide biosynthetic process
CF58_RS14245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CF58_RS14250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CF58_RS14255	COG0662	Cupin 2, conserved barrel domain protein
CF58_RS14255	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CF58_RS14260	COG0297	glycogen (starch) synthase activity
CF58_RS14265	COG1051	belongs to the nudix hydrolase family
CF58_RS14270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF58_RS14275	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CF58_RS14280	COG0110	maltose O-acetyltransferase activity
CF58_RS14285	COG1216	Glycosyl transferase, family 2
CF58_RS14295	COG0438	transferase activity, transferring glycosyl groups
CF58_RS14300	COG1045	serine acetyltransferase
CF58_RS14305	COG0463	Glycosyl transferase, family 2
CF58_RS14310	COG3206	protein involved in exopolysaccharide biosynthesis
CF58_RS14310	COG0489	protein tyrosine kinase activity
CF58_RS14315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CF58_RS14320	COG1596	polysaccharide export
CF58_RS14325	COG1253	flavin adenine dinucleotide binding
CF58_RS14330	COG2982	Protein involved in outer membrane biogenesis
CF58_RS14340	COG0572	uridine kinase
CF58_RS14345	COG5001	Diguanylate cyclase
CF58_RS14345	COG5002	protein histidine kinase activity
CF58_RS14345	COG3447	MASE1 domain protein
CF58_RS14350	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CF58_RS14355	COG0443	Heat shock 70 kDa protein
CF58_RS14360	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
CF58_RS14365	COG0631	protein serine/threonine phosphatase activity
CF58_RS14370	COG4245	von Willebrand factor, type A
CF58_RS14395	COG2205	protein histidine kinase activity
CF58_RS14400	COG0745	RESPONSE REGULATOR receiver
CF58_RS14410	COG0826	peptidase U32
CF58_RS14455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF58_RS14475	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF58_RS14580	COG4695	Portal protein
CF58_RS14635	COG4974	Belongs to the 'phage' integrase family
CF58_RS14660	COG1063	alcohol dehydrogenase
CF58_RS14665	COG3775	system Galactitol-specific IIC component
CF58_RS14670	COG3414	Phosphotransferase system galactitol-specific IIB component
CF58_RS14675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS14680	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
CF58_RS14690	COG1830	Aldolase
CF58_RS14695	COG2211	Major facilitator Superfamily
CF58_RS14700	COG1397	ADP-ribosylglycohydrolase
CF58_RS14705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF58_RS14710	COG2188	Transcriptional regulator
CF58_RS14715	COG3757	hydrolase, family 25
CF58_RS14720	COG0351	phosphomethylpyrimidine kinase
CF58_RS14740	COG5455	response to cobalt ion
CF58_RS14745	COG3539	Fimbrial protein
CF58_RS14750	COG3188	usher protein
CF58_RS14755	COG3121	Chaperone
CF58_RS14760	COG3539	Fimbrial protein
CF58_RS14775	COG0489	protein tyrosine kinase activity
CF58_RS14785	COG3831	ATPase activity
CF58_RS14790	COG3831	ATPase activity
CF58_RS14805	COG0714	Associated with various cellular activities
CF58_RS14815	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CF58_RS14820	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CF58_RS14825	COG4715	Zinc finger, swim domain protein
CF58_RS14830	COG4808	Protein conserved in bacteria
CF58_RS14835	COG4807	Protein conserved in bacteria
CF58_RS14840	COG3279	Response regulator of the LytR AlgR family
CF58_RS14845	COG3275	phosphorelay sensor kinase activity
CF58_RS14850	COG0789	Transcriptional regulator
CF58_RS14860	COG1174	glycine betaine transport
CF58_RS14865	COG1125	glycine betaine transport
CF58_RS14870	COG1174	glycine betaine transport
CF58_RS14875	COG1732	Glycine betaine
CF58_RS14880	COG1472	Belongs to the glycosyl hydrolase 3 family
CF58_RS14885	COG0277	FAD linked oxidase domain protein
CF58_RS14890	COG1686	Belongs to the peptidase S11 family
CF58_RS14900	COG0586	Pfam SNARE associated Golgi protein
CF58_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS14920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF58_RS14925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF58_RS14930	COG0625	glutathione transferase activity
CF58_RS14945	COG2271	Major facilitator Superfamily
CF58_RS14960	COG1346	cytolysis
CF58_RS14970	COG2949	membrane
CF58_RS14980	COG0493	'glutamate synthase
CF58_RS14985	COG0167	dihydroorotate dehydrogenase activity
CF58_RS14985	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CF58_RS14990	COG4211	Belongs to the binding-protein-dependent transport system permease family
CF58_RS14995	COG1129	ABC transporter
CF58_RS15000	COG1879	ABC-type sugar transport system periplasmic component
CF58_RS15005	COG1609	Transcriptional regulator
CF58_RS15015	COG2311	Membrane
CF58_RS15035	COG4771	TonB-dependent receptor
CF58_RS15045	COG0833	amino acid
CF58_RS15050	COG0583	DNA-binding transcription factor activity
CF58_RS15055	COG2855	membrane
CF58_RS15065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF58_RS15065	COG1522	sequence-specific DNA binding
CF58_RS15070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF58_RS15080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF58_RS15085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF58_RS15090	COG2313	pseudouridylate synthase activity
CF58_RS15095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF58_RS15100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS15100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS15100	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CF58_RS15105	COG1105	Belongs to the carbohydrate kinase PfkB family
CF58_RS15110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS15110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS15115	COG2814	Major facilitator Superfamily
CF58_RS15130	COG0246	Mannitol dehydrogenase
CF58_RS15135	COG0523	cobalamin synthesis protein
CF58_RS15140	COG0671	phosphoesterase, PA-phosphatase related
CF58_RS15145	COG0791	NLP P60 protein
CF58_RS15150	COG2200	EAL domain
CF58_RS15155	COG4166	transmembrane transport
CF58_RS15160	COG4174	ABC transporter (Permease)
CF58_RS15165	COG4239	(ABC) transporter, permease
CF58_RS15170	COG4172	Belongs to the ABC transporter superfamily
CF58_RS15180	COG2814	Major facilitator Superfamily
CF58_RS15185	COG1187	pseudouridine synthase activity
CF58_RS15190	COG1061	Type III restriction enzyme res subunit
CF58_RS15210	COG3083	sulfuric ester hydrolase activity
CF58_RS15220	COG3468	outer membrane autotransporter barrel domain protein
CF58_RS15230	COG2197	response regulator
CF58_RS15235	COG4235	cytochrome complex assembly
CF58_RS15235	COG3088	subunit of a heme lyase
CF58_RS15240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CF58_RS15245	COG1138	Cytochrome C-type biogenesis protein
CF58_RS15255	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF58_RS15260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF58_RS15265	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF58_RS15270	COG4133	protoheme IX ABC transporter activity
CF58_RS15275	COG3005	denitrification pathway
CF58_RS15280	COG3043	anaerobic respiration
CF58_RS15285	COG0348	domain, Protein
CF58_RS15290	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS15300	COG3062	negative regulation of establishment of protein localization
CF58_RS15305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS15305	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS15325	COG4615	Cyclic peptide transporter
CF58_RS15330	COG3145	DNA-N1-methyladenine dioxygenase activity
CF58_RS15335	COG2169	Transcriptional regulator
CF58_RS15335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CF58_RS15340	COG1477	protein flavinylation
CF58_RS15345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF58_RS15355	COG0642	Histidine kinase
CF58_RS15355	COG2198	Histidine kinase
CF58_RS15360	COG2197	response regulator
CF58_RS15365	COG2205	protein histidine kinase activity
CF58_RS15365	COG0784	Response regulator, receiver
CF58_RS15370	COG3852	Histidine kinase
CF58_RS15375	COG2204	response regulator
CF58_RS15380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CF58_RS15385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CF58_RS15390	COG2031	fatty acid transporter
CF58_RS15395	COG0183	Belongs to the thiolase family
CF58_RS15400	COG4676	Protein conserved in bacteria
CF58_RS15405	COG5445	Predicted secreted protein (DUF2300)
CF58_RS15410	COG2373	Large extracellular alpha-helical protein
CF58_RS15415	COG3234	Protein of unknown function (DUF1175)
CF58_RS15420	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
CF58_RS15425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF58_RS15445	COG2801	Transposase and inactivated derivatives
CF58_RS15450	COG3468	outer membrane autotransporter barrel domain protein
CF58_RS15460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF58_RS15465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF58_RS15470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF58_RS15475	COG3642	lipopolysaccharide core region biosynthetic process
CF58_RS15480	COG2814	Major facilitator Superfamily
CF58_RS15485	COG0583	DNA-binding transcription factor activity
CF58_RS15490	COG0584	glycerophosphoryl diester phosphodiesterase
CF58_RS15495	COG2271	Major facilitator Superfamily
CF58_RS15500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CF58_RS15510	COG0247	lactate metabolic process
CF58_RS15515	COG5464	transposase or invertase
CF58_RS15530	COG2271	Major facilitator Superfamily
CF58_RS15540	COG1414	Transcriptional regulator
CF58_RS15605	COG0318	PFAM AMP-dependent synthetase and ligase
CF58_RS15615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CF58_RS15630	COG1169	isochorismate synthase
CF58_RS15635	COG4575	ribosome binding
CF58_RS15640	COG2153	protein acetylation
CF58_RS15655	COG2234	aminopeptidase activity
CF58_RS15670	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF58_RS15675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CF58_RS15685	COG0839	Belongs to the complex I subunit 6 family
CF58_RS15700	COG1034	ATP synthesis coupled electron transport
CF58_RS15705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CF58_RS15710	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CF58_RS15730	COG0583	DNA-binding transcription factor activity
CF58_RS15735	COG0436	Aminotransferase
CF58_RS15745	COG0471	metal ion transport
CF58_RS15745	COG0490	domain, Protein
CF58_RS15750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF58_RS15770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CF58_RS15775	COG0280	phosphate acetyltransferase
CF58_RS15775	COG0857	belongs to the CobB CobQ family
CF58_RS15780	COG1288	antiporter activity
CF58_RS15785	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CF58_RS15790	COG0622	Phosphoesterase
CF58_RS15795	COG0625	glutathione transferase activity
CF58_RS15800	COG0625	glutathione transferase activity
CF58_RS15805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CF58_RS15810	COG1090	epimerase
CF58_RS15815	COG5464	transposase or invertase
CF58_RS15820	COG4598	ABC transporter
CF58_RS15825	COG4160	amino acid transport
CF58_RS15830	COG4215	(ABC) transporter
CF58_RS15835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS15840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS15845	COG0163	prenyltransferase activity
CF58_RS15850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CF58_RS15855	COG1286	toxin biosynthetic process
CF58_RS15860	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CF58_RS15865	COG0285	dihydrofolate synthase activity
CF58_RS15875	COG0586	Pfam SNARE associated Golgi protein
CF58_RS15885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF58_RS15900	COG2814	Major facilitator Superfamily
CF58_RS15905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF58_RS15920	COG3101	peptidyl-lysine hydroxylation
CF58_RS15925	COG0730	response to heat
CF58_RS15950	COG2801	Transposase and inactivated derivatives
CF58_RS15970	COG3539	Fimbrial protein
CF58_RS15975	COG3539	Fimbrial protein
CF58_RS15980	COG3539	Fimbrial protein
CF58_RS15985	COG3121	Chaperone
CF58_RS15990	COG3188	usher protein
CF58_RS15995	COG3539	Fimbrial protein
CF58_RS16000	COG2062	phosphohistidine phosphatase, SixA
CF58_RS16015	COG3691	Protein conserved in bacteria
CF58_RS16020	COG2067	long-chain fatty acid transport protein
CF58_RS16030	COG2853	Lipoprotein
CF58_RS16035	COG2116	formate transmembrane transporter activity
CF58_RS16045	COG0582	viral genome integration into host DNA
CF58_RS16105	COG2610	gluconate transmembrane transporter activity
CF58_RS16115	COG0477	Major facilitator Superfamily
CF58_RS16120	COG1566	PFAM secretion protein HlyD family protein
CF58_RS16125	COG2197	response regulator
CF58_RS16130	COG2205	protein histidine kinase activity
CF58_RS16130	COG0784	Response regulator, receiver
CF58_RS16130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS16130	COG2198	Histidine kinase
CF58_RS16135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CF58_RS16140	COG0679	Auxin Efflux Carrier
CF58_RS16145	COG0028	Belongs to the TPP enzyme family
CF58_RS16175	COG1560	Kdo2-lipid A biosynthetic process
CF58_RS16180	COG0436	Aminotransferase
CF58_RS16185	COG3275	phosphorelay sensor kinase activity
CF58_RS16190	COG3279	Response regulator of the LytR AlgR family
CF58_RS16195	COG2207	Transcriptional regulator
CF58_RS16205	COG1363	Peptidase, m42
CF58_RS16210	COG0006	proline dipeptidase activity
CF58_RS16215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS16220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF58_RS16250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF58_RS16255	COG2200	EAL domain
CF58_RS16255	COG2199	diguanylate cyclase activity
CF58_RS16270	COG3415	Transposase
CF58_RS16275	COG3415	Transposase
CF58_RS16305	COG0583	DNA-binding transcription factor activity
CF58_RS16315	COG2211	Major facilitator Superfamily
CF58_RS16320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CF58_RS16330	COG0583	DNA-binding transcription factor activity
CF58_RS16335	COG0385	Bile acid
CF58_RS16340	COG3530	Putative quorum-sensing-regulated virulence factor
CF58_RS16360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CF58_RS16365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS16370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF58_RS16375	COG2190	(PTS) system
CF58_RS16390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CF58_RS16395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CF58_RS16400	COG4208	sulfate ABC transporter
CF58_RS16405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CF58_RS16410	COG4150	thiosulfate binding
CF58_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS16430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS16430	COG1263	PTS System
CF58_RS16435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF58_RS16440	COG2837	iron assimilation
CF58_RS16460	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF58_RS16470	COG2207	Transcriptional regulator
CF58_RS16475	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CF58_RS16480	COG4816	utilization protein
CF58_RS16490	COG4303	Ethanolamine ammonia lyase large subunit
CF58_RS16495	COG4819	ethanolamine utilization protein
CF58_RS16500	COG3192	ethanolamine utilization protein
CF58_RS16505	COG1454	alcohol dehydrogenase
CF58_RS16510	COG4820	ethanolamine utilization protein (EutJ)
CF58_RS16515	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS16520	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CF58_RS16525	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CF58_RS16530	COG0280	phosphate acetyltransferase
CF58_RS16535	COG4812	Cobalamin adenosyltransferase
CF58_RS16540	COG4766	ethanolamine catabolic process
CF58_RS16545	COG4917	ethanolamine utilization protein
CF58_RS16550	COG4810	utilization protein
CF58_RS16555	COG0281	malic enzyme
CF58_RS16555	COG0280	phosphate acetyltransferase
CF58_RS16560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF58_RS16565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CF58_RS16570	COG5342	invasion associated locus B
CF58_RS16580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS16580	COG0493	'glutamate synthase
CF58_RS16585	COG3850	Histidine kinase
CF58_RS16590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF58_RS16600	COG1393	Belongs to the ArsC family
CF58_RS16625	COG2801	Transposase and inactivated derivatives
CF58_RS16630	COG0400	carboxylic ester hydrolase activity
CF58_RS16635	COG1444	tRNA N-acetyltransferase activity
CF58_RS16640	COG2321	neutral zinc metallopeptidase
CF58_RS16655	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CF58_RS16665	COG2716	regulation of RNA biosynthetic process
CF58_RS16670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CF58_RS16675	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS16680	COG0651	ATP synthesis coupled electron transport
CF58_RS16685	COG0650	Formate hydrogenlyase subunit 4
CF58_RS16690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CF58_RS16695	COG4237	Hydrogenase 4 membrane
CF58_RS16700	COG0651	ATP synthesis coupled electron transport
CF58_RS16705	COG3261	NADH dehydrogenase
CF58_RS16705	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CF58_RS16710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF58_RS16715	COG3260	NADH ubiquinone oxidoreductase 20
CF58_RS16725	COG3604	Transcriptional regulator
CF58_RS16730	COG2116	formate transmembrane transporter activity
CF58_RS16735	COG0628	permease
CF58_RS16740	COG4783	chaperone-mediated protein folding
CF58_RS16745	COG1393	Belongs to the ArsC family
CF58_RS16755	COG2233	PERMEase
CF58_RS16770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CF58_RS16775	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CF58_RS16780	COG0248	Ppx GppA phosphatase
CF58_RS16785	COG2200	EAL domain
CF58_RS16800	COG3133	Outer membrane lipoprotein
CF58_RS16815	COG0516	GMP reductase activity
CF58_RS16815	COG0517	IMP dehydrogenase activity
CF58_RS16840	COG1645	bacterial-type flagellum-dependent swarming motility
CF58_RS16855	COG2976	Protein conserved in bacteria
CF58_RS16885	COG4953	penicillin-binding protein 1C
CF58_RS16890	COG2373	Large extracellular alpha-helical protein
CF58_RS16895	COG2897	thiosulfate sulfurtransferase activity
CF58_RS16910	COG2975	iron-sulfur cluster assembly
CF58_RS16915	COG0633	Ferredoxin
CF58_RS16935	COG0822	iron-sulfur transferase activity
CF58_RS16955	COG0483	inositol monophosphate 1-phosphatase activity
CF58_RS16960	COG1073	alpha beta
CF58_RS16965	COG3711	transcriptional antiterminator
CF58_RS16970	COG2814	Major facilitator Superfamily
CF58_RS16975	COG0583	DNA-binding transcription factor activity
CF58_RS16980	COG4638	Rieske (2fe-2S)
CF58_RS17005	COG2259	Doxx family
CF58_RS17010	COG2017	converts alpha-aldose to the beta-anomer
CF58_RS17015	COG1063	alcohol dehydrogenase
CF58_RS17020	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF58_RS17025	COG1129	ABC transporter
CF58_RS17030	COG1879	ABC-type sugar transport system periplasmic component
CF58_RS17035	COG0457	Tetratricopeptide repeat
CF58_RS17040	COG1940	carbohydrate kinase activity
CF58_RS17055	COG1017	nitric oxide dioxygenase activity
CF58_RS17055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF58_RS17060	COG0347	Belongs to the P(II) protein family
CF58_RS17065	COG2204	response regulator
CF58_RS17070	COG3170	Tfp pilus assembly protein FimV
CF58_RS17075	COG2205	protein histidine kinase activity
CF58_RS17080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CF58_RS17080	COG0047	phosphoribosylformylglycinamidine synthase activity
CF58_RS17095	COG0560	Phosphoserine phosphatase
CF58_RS17100	COG1737	Transcriptional regulator
CF58_RS17105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS17130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CF58_RS17150	COG0681	Belongs to the peptidase S26 family
CF58_RS17160	COG3086	response to oxidative stress
CF58_RS17165	COG3026	antisigma factor binding
CF58_RS17170	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CF58_RS17175	COG1595	DNA-templated transcription, initiation
CF58_RS17185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CF58_RS17195	COG0513	Belongs to the DEAD box helicase family
CF58_RS17200	COG0583	DNA-binding transcription factor activity
CF58_RS17220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF58_RS17230	COG3118	belongs to the thioredoxin family
CF58_RS17235	COG3148	PFAM DTW domain containing protein
CF58_RS17240	COG1042	CoA-binding domain protein
CF58_RS17240	COG0045	succinate-CoA ligase (ADP-forming) activity
CF58_RS17240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF58_RS17245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF58_RS17250	COG5544	Lipoprotein
CF58_RS17255	COG0477	Major facilitator Superfamily
CF58_RS17260	COG2801	Transposase and inactivated derivatives
CF58_RS17300	COG0542	response to heat
CF58_RS17310	COG0564	pseudouridine synthase activity
CF58_RS17315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF58_RS17325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF58_RS17330	COG0077	Prephenate dehydratase
CF58_RS17330	COG1605	Chorismate mutase
CF58_RS17335	COG0287	Prephenate dehydrogenase
CF58_RS17335	COG1605	Chorismate mutase
CF58_RS17340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF58_RS17355	COG2199	diguanylate cyclase activity
CF58_RS17360	COG2885	chlorophyll binding
CF58_RS17385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CF58_RS17390	COG4137	Cytochrome C assembly protein
CF58_RS17395	COG4536	flavin adenine dinucleotide binding
CF58_RS17415	COG0497	DNA recombination
CF58_RS17420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF58_RS17430	COG2867	negative regulation of translational initiation
CF58_RS17440	COG0582	viral genome integration into host DNA
CF58_RS17515	COG0366	Alpha amylase catalytic
CF58_RS17525	COG0579	oxidoreductase
CF58_RS17530	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS17535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CF58_RS17540	COG1113	amino acid transport
CF58_RS17545	COG1802	Transcriptional regulator
CF58_RS17550	COG1652	LysM domain
CF58_RS17555	COG0401	homolog of Blt101
CF58_RS17560	COG0640	Transcriptional regulator
CF58_RS17565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF58_RS17570	COG2916	Histone family protein nucleoid-structuring protein H-NS
CF58_RS17585	COG4575	ribosome binding
CF58_RS17590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF58_RS17595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF58_RS17600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF58_RS17610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF58_RS17615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF58_RS17620	COG4175	Glycine betaine
CF58_RS17625	COG4176	ABC-type proline glycine betaine transport system permease component
CF58_RS17630	COG2113	Glycine betaine
CF58_RS17635	COG2814	Major facilitator Superfamily
CF58_RS17640	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CF58_RS17650	COG1846	Transcriptional regulator
CF58_RS17655	COG1566	PFAM secretion protein HlyD family protein
CF58_RS17660	COG2814	Major facilitator Superfamily
CF58_RS17675	COG1238	metal cluster binding
CF58_RS17680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF58_RS17715	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CF58_RS17740	COG1546	Belongs to the CinA family
CF58_RS17745	COG2951	lytic endotransglycosylase activity
CF58_RS17750	COG3730	PTS system glucitol sorbitol-specific
CF58_RS17755	COG3732	PTS system glucitol sorbitol-specific
CF58_RS17765	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS17770	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS17775	COG1349	DNA-binding transcription factor activity
CF58_RS17800	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CF58_RS17805	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS17810	COG1609	Transcriptional regulator
CF58_RS17815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS17815	COG1263	PTS System
CF58_RS17820	COG2723	6-phospho-beta-galactosidase activity
CF58_RS17825	COG5499	transcription regulator containing HTH domain
CF58_RS17830	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF58_RS17840	COG3260	NADH ubiquinone oxidoreductase 20
CF58_RS17845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF58_RS17850	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CF58_RS17850	COG3261	NADH dehydrogenase
CF58_RS17855	COG0650	Formate hydrogenlyase subunit 4
CF58_RS17860	COG0651	ATP synthesis coupled electron transport
CF58_RS17865	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS17880	COG0375	protein maturation
CF58_RS17885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CF58_RS17890	COG0298	carbon dioxide binding
CF58_RS17895	COG0409	Hydrogenase expression formation protein
CF58_RS17900	COG0309	Hydrogenase expression formation protein (HypE)
CF58_RS17905	COG3604	Transcriptional regulator
CF58_RS17930	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CF58_RS17940	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CF58_RS17945	COG0163	prenyltransferase activity
CF58_RS17955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF58_RS17960	COG4942	peptidase
CF58_RS17960	COG1388	LysM domain
CF58_RS18015	COG2234	aminopeptidase activity
CF58_RS18020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF58_RS18025	COG1518	maintenance of DNA repeat elements
CF58_RS18040	COG1857	crispr-associated protein
CF58_RS18055	COG1203	CRISPR-associated helicase, Cas3
CF58_RS18080	COG0720	synthase
CF58_RS18085	COG0644	oxidoreductase
CF58_RS18090	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF58_RS18095	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CF58_RS18100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CF58_RS18105	COG2086	electron transfer activity
CF58_RS18110	COG0477	Major facilitator Superfamily
CF58_RS18115	COG0277	FAD linked oxidase domain protein
CF58_RS18120	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS18125	COG2223	nitrite transmembrane transporter activity
CF58_RS18135	COG0602	queuosine metabolic process
CF58_RS18145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CF58_RS18160	COG3956	TIGRFAM MazG family protein
CF58_RS18165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF58_RS18175	COG4999	Histidine kinase
CF58_RS18175	COG3850	Histidine kinase
CF58_RS18175	COG3437	response regulator, receiver
CF58_RS18175	COG2205	protein histidine kinase activity
CF58_RS18180	COG4948	Mandelate Racemase Muconate Lactonizing
CF58_RS18185	COG4948	Mandelate Racemase Muconate Lactonizing
CF58_RS18190	COG2271	Major facilitator Superfamily
CF58_RS18195	COG0716	FMN binding
CF58_RS18200	COG0564	pseudouridine synthase activity
CF58_RS18205	COG3098	single-species biofilm formation
CF58_RS18225	COG1611	Belongs to the LOG family
CF58_RS18230	COG0814	amino acid
CF58_RS18235	COG1760	l-serine dehydratase
CF58_RS18245	COG1454	alcohol dehydrogenase
CF58_RS18250	COG0235	Class ii aldolase
CF58_RS18255	COG0738	Major facilitator superfamily
CF58_RS18265	COG1070	Carbohydrate kinase
CF58_RS18275	COG1349	DNA-binding transcription factor activity
CF58_RS18285	COG2363	Small membrane protein
CF58_RS18290	COG0583	DNA-binding transcription factor activity
CF58_RS18300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CF58_RS18305	COG2166	iron-sulfur cluster assembly
CF58_RS18310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CF58_RS18315	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CF58_RS18335	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF58_RS18340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CF58_RS18340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CF58_RS18345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CF58_RS18350	COG1074	ATP-dependent DNA helicase activity
CF58_RS18360	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CF58_RS18365	COG4967	type IV pilus modification protein PilV
CF58_RS18375	COG4795	General secretion pathway protein
CF58_RS18380	COG2165	general secretion pathway protein
CF58_RS18395	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CF58_RS18420	COG0861	Integral membrane protein TerC family
CF58_RS18430	COG0667	Aldo Keto reductase
CF58_RS18445	COG1609	Transcriptional regulator
CF58_RS18455	COG0583	DNA-binding transcription factor activity
CF58_RS18460	COG1794	racemase activity, acting on amino acids and derivatives
CF58_RS18465	COG2814	Major facilitator Superfamily
CF58_RS18470	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS18480	COG0183	Belongs to the thiolase family
CF58_RS18485	COG0814	amino acid
CF58_RS18490	COG2771	luxR family
CF58_RS18495	COG3710	Transcriptional regulator
CF58_RS18525	COG0457	Tetratricopeptide repeat
CF58_RS18530	COG0457	Tetratricopeptide repeat
CF58_RS18530	COG3710	Transcriptional regulator
CF58_RS18540	COG0741	lytic transglycosylase activity
CF58_RS18545	COG2197	response regulator
CF58_RS18650	COG2207	Transcriptional regulator
CF58_RS18660	COG3387	PFAM Glycoside hydrolase 15-related
CF58_RS18670	COG4942	peptidase
CF58_RS18675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF58_RS18680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF58_RS18685	COG2080	2 iron, 2 sulfur cluster binding
CF58_RS18690	COG3829	transcription factor binding
CF58_RS18695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CF58_RS18700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF58_RS18705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CF58_RS18715	COG0549	Belongs to the carbamate kinase family
CF58_RS18720	COG3608	succinylglutamate desuccinylase aspartoacylase
CF58_RS18720	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CF58_RS18725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CF58_RS18730	COG2068	MobA-Related Protein
CF58_RS18735	COG0493	'glutamate synthase
CF58_RS18735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS18740	COG0402	S-adenosylhomocysteine deaminase activity
CF58_RS18745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF58_RS18750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF58_RS18750	COG2080	2 iron, 2 sulfur cluster binding
CF58_RS18755	COG2233	PERMEase
CF58_RS18760	COG0402	S-adenosylhomocysteine deaminase activity
CF58_RS18765	COG2252	PERMEase
CF58_RS18770	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS18775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS18775	COG0493	'glutamate synthase
CF58_RS18785	COG2233	PERMEase
CF58_RS18800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CF58_RS18810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CF58_RS18815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF58_RS18820	COG4974	Belongs to the 'phage' integrase family
CF58_RS18825	COG0716	FMN binding
CF58_RS18835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CF58_RS18845	COG1272	protein, Hemolysin III
CF58_RS18855	COG2723	6-phospho-beta-galactosidase activity
CF58_RS18875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF58_RS18880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF58_RS18885	COG0006	proline dipeptidase activity
CF58_RS18900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CF58_RS18910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CF58_RS18925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF58_RS18925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF58_RS18930	COG1703	isobutyryl-CoA mutase activity
CF58_RS18940	COG0427	acetyl-CoA hydrolase
CF58_RS18945	COG0583	DNA-binding transcription factor activity
CF58_RS18950	COG2968	Membrane
CF58_RS18955	COG1279	arginine transmembrane transporter activity
CF58_RS18960	COG0668	transmembrane transport
CF58_RS18965	COG0191	fructose-bisphosphate aldolase activity
CF58_RS18980	COG1072	(Pantothenic acid kinase))
CF58_RS18990	COG1494	fructose-1,6-bisphosphatase
CF58_RS18995	COG1063	alcohol dehydrogenase
CF58_RS19000	COG2213	PTS system mannitol-specific
CF58_RS19005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS19010	COG0330	HflC and HflK could
CF58_RS19015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CF58_RS19020	COG0501	Belongs to the peptidase M48B family
CF58_RS19035	COG2801	Transposase and inactivated derivatives
CF58_RS19050	COG1166	arginine decarboxylase activity
CF58_RS19075	COG2814	Major facilitator Superfamily
CF58_RS19085	COG2356	endonuclease I
CF58_RS19090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CF58_RS19095	COG0189	ligase activity
CF58_RS19110	COG2805	Type II/IV secretion system protein
CF58_RS19115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CF58_RS19120	COG0762	integral membrane protein
CF58_RS19135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF58_RS19140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CF58_RS19145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CF58_RS19160	COG0252	asparaginase activity
CF58_RS19175	COG3171	Protein conserved in bacteria
CF58_RS19185	COG1194	a g-specific adenine glycosylase
CF58_RS19200	COG2211	Major facilitator Superfamily
CF58_RS19205	COG1982	Orn Lys Arg decarboxylase major
CF58_RS19210	COG1811	Na channel or pump
CF58_RS19270	COG0110	maltose O-acetyltransferase activity
CF58_RS19275	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CF58_RS19305	COG2165	general secretion pathway protein
CF58_RS19310	COG1459	type II secretion system
CF58_RS19315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF58_RS19335	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CF58_RS19340	COG3064	Membrane
CF58_RS19350	COG1620	l-lactate permease
CF58_RS19355	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CF58_RS19360	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CF58_RS19365	COG0247	lactate metabolic process
CF58_RS19370	COG0277	FAD linked oxidase domain protein
CF58_RS19375	COG0277	FAD linked oxidase domain protein
CF58_RS19380	COG2186	Transcriptional regulator
CF58_RS19385	COG0456	acetyltransferase
CF58_RS19390	COG0318	PFAM AMP-dependent synthetase and ligase
CF58_RS19400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CF58_RS19405	COG0156	8-amino-7-oxononanoate synthase activity
CF58_RS19415	COG0795	lipopolysaccharide-transporting ATPase activity
CF58_RS19420	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CF58_RS19430	COG2244	polysaccharide biosynthetic process
CF58_RS19435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF58_RS19440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF58_RS19445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF58_RS19450	COG0306	phosphate transporter
CF58_RS19455	COG0754	glutathionylspermidine amidase activity
CF58_RS19460	COG0625	glutathione transferase activity
CF58_RS19465	COG0298	carbon dioxide binding
CF58_RS19475	COG1773	rubredoxin
CF58_RS19480	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF58_RS19485	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CF58_RS19490	COG5557	Pfam Polysulphide reductase, NrfD
CF58_RS19495	COG0437	4 iron, 4 sulfur cluster binding
CF58_RS19500	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CF58_RS19520	COG0667	Aldo Keto reductase
CF58_RS19530	COG1028	Short-chain dehydrogenase reductase Sdr
CF58_RS19535	COG0848	biopolymer transport protein
CF58_RS19540	COG0811	peptide transport
CF58_RS19550	COG0626	cystathionine gamma-synthase activity
CF58_RS19555	COG0586	Pfam SNARE associated Golgi protein
CF58_RS19560	COG2207	Transcriptional regulator
CF58_RS19570	COG1979	alcohol dehydrogenase
CF58_RS19575	COG0656	L-ascorbic acid biosynthetic process
CF58_RS19585	COG4238	major outer membrane lipoprotein
CF58_RS19590	COG1032	radical SAM domain protein
CF58_RS19595	COG2132	Multicopper oxidase
CF58_RS19600	COG0204	Acyl-transferase
CF58_RS19605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF58_RS19610	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CF58_RS19615	COG3111	PFAM Bacterial OB fold (BOF) protein
CF58_RS19620	COG0745	RESPONSE REGULATOR receiver
CF58_RS19625	COG0642	Histidine kinase
CF58_RS19645	COG2249	NAD(P)H dehydrogenase (quinone) activity
CF58_RS19650	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CF58_RS19655	COG1737	Transcriptional regulator
CF58_RS19665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF58_RS19670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF58_RS19675	COG1120	ATPase activity
CF58_RS19680	COG4774	siderophore transport
CF58_RS19685	COG0187	DNA topoisomerase II activity
CF58_RS19690	COG3150	esterase
CF58_RS19695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CF58_RS19700	COG3151	Protein conserved in bacteria
CF58_RS19705	COG0494	nUDIX hydrolase
CF58_RS19710	COG1538	Outer membrane efflux protein
CF58_RS19725	COG0754	glutathionylspermidine amidase activity
CF58_RS19735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CF58_RS19740	COG2963	transposase activity
CF58_RS19745	COG2801	Transposase and inactivated derivatives
CF58_RS19755	COG3384	dioxygenase
CF58_RS19770	COG3539	Fimbrial protein
CF58_RS19775	COG3188	usher protein
CF58_RS19780	COG3121	Chaperone
CF58_RS19785	COG3539	Fimbrial protein
CF58_RS19805	COG1585	Membrane protein implicated in regulation of membrane protease activity
CF58_RS19810	COG2268	Band 7 protein
CF58_RS19830	COG3025	triphosphatase activity
CF58_RS19840	COG4991	sh3 domain protein
CF58_RS19855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CF58_RS19870	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF58_RS19875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF58_RS19890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CF58_RS19895	COG0358	DNA primase activity
CF58_RS19900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF58_RS19915	COG2375	cellular response to nickel ion
CF58_RS19920	COG1695	Transcriptional regulator
CF58_RS19925	COG0840	transmembrane signaling receptor activity
CF58_RS19935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CF58_RS19940	COG1609	Transcriptional regulator
CF58_RS19945	COG3250	beta-galactosidase activity
CF58_RS19950	COG2731	YhcH YjgK YiaL family protein
CF58_RS19955	COG0531	amino acid
CF58_RS19965	COG3408	Glycogen debranching enzyme
CF58_RS19965	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CF58_RS19970	COG1902	pentaerythritol trinitrate reductase activity
CF58_RS19970	COG0446	pyridine nucleotide-disulphide oxidoreductase
CF58_RS19975	COG5499	transcription regulator containing HTH domain
CF58_RS19980	COG4680	protein conserved in bacteria
CF58_RS19995	COG1451	nucleotide metabolic process
CF58_RS20000	COG2949	membrane
CF58_RS20005	COG0673	inositol 2-dehydrogenase activity
CF58_RS20010	COG0861	Integral membrane protein TerC family
CF58_RS20015	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CF58_RS20025	COG2721	sulfolactate sulfo-lyase activity
CF58_RS20035	COG2271	Major facilitator Superfamily
CF58_RS20040	COG2186	Transcriptional regulator
CF58_RS20045	COG0586	Pfam SNARE associated Golgi protein
CF58_RS20055	COG1422	Protein of unknown function (DUF1090)
CF58_RS20060	COG4575	ribosome binding
CF58_RS20065	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CF58_RS20075	COG2259	Doxx family
CF58_RS20080	COG0435	Glutathione S-transferase
CF58_RS20090	COG3152	Membrane
CF58_RS20095	COG3152	Membrane
CF58_RS20100	COG0583	DNA-binding transcription factor activity
CF58_RS20105	COG1741	Belongs to the pirin family
CF58_RS20120	COG0814	amino acid
CF58_RS20125	COG1760	l-serine dehydratase
CF58_RS20130	COG0251	oxidation-reduction process
CF58_RS20135	COG1882	Formate acetyltransferase
CF58_RS20140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CF58_RS20150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF58_RS20155	COG0583	DNA-binding transcription factor activity
CF58_RS20180	COG1929	Belongs to the glycerate kinase type-1 family
CF58_RS20185	COG2084	Dehydrogenase
CF58_RS20195	COG2271	Major facilitator Superfamily
CF58_RS20200	COG2721	sulfolactate sulfo-lyase activity
CF58_RS20205	COG2002	toxin-antitoxin pair type II binding
CF58_RS20215	COG1349	DNA-binding transcription factor activity
CF58_RS20225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS20235	COG3716	PTS system mannose fructose sorbose family IID component
CF58_RS20240	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS20245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF58_RS20250	COG2222	sugar isomerase
CF58_RS20260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF58_RS20265	COG3715	PTS system
CF58_RS20270	COG3716	PTS system mannose fructose sorbose family IID component
CF58_RS20275	COG0363	glucosamine-6-phosphate deaminase activity
CF58_RS20280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CF58_RS20300	COG2823	Periplasmic or secreted lipoprotein
CF58_RS20305	COG0701	Predicted permease
CF58_RS20310	COG0702	epimerase
CF58_RS20315	COG0693	protein deglycase activity
CF58_RS20330	COG3153	acetyltransferase
CF58_RS20335	COG3154	lipid carrier protein
CF58_RS20340	COG0826	peptidase U32
CF58_RS20345	COG0826	peptidase U32
CF58_RS20350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CF58_RS20355	COG0814	amino acid
CF58_RS20365	COG0513	Belongs to the DEAD box helicase family
CF58_RS20400	COG0195	Participates in both transcription termination and antitermination
CF58_RS20420	COG2194	sulfuric ester hydrolase activity
CF58_RS20430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF58_RS20440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CF58_RS20445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CF58_RS20455	COG1534	Rna-binding protein
CF58_RS20460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF58_RS20465	COG2027	D-alanyl-D-alanine carboxypeptidase
CF58_RS20475	COG0697	spore germination
CF58_RS20490	COG0142	geranyltranstransferase activity
CF58_RS20495	COG3423	Transcriptional regulator
CF58_RS20505	COG5007	Belongs to the BolA IbaG family
CF58_RS20510	COG3113	response to antibiotic
CF58_RS20515	COG2854	intermembrane phospholipid transfer
CF58_RS20520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CF58_RS20525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CF58_RS20530	COG1127	ABC transporter
CF58_RS20535	COG0530	calcium, potassium:sodium antiporter activity
CF58_RS20540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CF58_RS20540	COG0517	IMP dehydrogenase activity
CF58_RS20545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CF58_RS20550	COG3117	lipopolysaccharide transmembrane transporter activity
CF58_RS20555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CF58_RS20560	COG1137	ATPase activity
CF58_RS20565	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CF58_RS20570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF58_RS20585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS20590	COG0515	serine threonine protein kinase
CF58_RS20600	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CF58_RS20605	COG2198	Histidine kinase
CF58_RS20605	COG0784	Response regulator, receiver
CF58_RS20605	COG5002	protein histidine kinase activity
CF58_RS20610	COG1242	4 iron, 4 sulfur cluster binding
CF58_RS20615	COG0069	glutamate synthase activity
CF58_RS20615	COG0067	glutamate synthase
CF58_RS20615	COG0070	glutamate synthase
CF58_RS20620	COG0493	'glutamate synthase
CF58_RS20625	COG4804	nuclease activity
CF58_RS20630	COG2731	YhcH YjgK YiaL family protein
CF58_RS20660	COG3069	C4-dicarboxylate transmembrane transporter activity
CF58_RS20665	COG2969	positive regulation of protein catabolic process
CF58_RS20670	COG0625	glutathione transferase activity
CF58_RS20685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CF58_RS20690	COG3105	Protein conserved in bacteria
CF58_RS20695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF58_RS20700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF58_RS20720	COG2732	(Barnase) inhibitor
CF58_RS20740	COG0583	DNA-binding transcription factor activity
CF58_RS20745	COG0312	modulator of DNA gyrase
CF58_RS20750	COG3164	Protein of unknown function
CF58_RS20755	COG1530	ribonuclease E activity
CF58_RS20765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CF58_RS20770	COG1792	Involved in formation and maintenance of cell shape
CF58_RS20775	COG1077	Cell shape determining protein MreB Mrl
CF58_RS20785	COG2200	EAL domain
CF58_RS20785	COG2199	diguanylate cyclase activity
CF58_RS20790	COG0604	alcohol dehydrogenase
CF58_RS20810	COG0511	ligase activity, forming carbon-carbon bonds
CF58_RS20815	COG0439	Biotin carboxylase
CF58_RS20820	COG3924	membrane
CF58_RS20825	COG4145	pantothenate transmembrane transporter activity
CF58_RS20835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF58_RS20845	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CF58_RS20855	COG1309	transcriptional regulator
CF58_RS20860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF58_RS20865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF58_RS20885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF58_RS20890	COG4597	amino acid ABC transporter
CF58_RS20895	COG0765	amino acid transport
CF58_RS20900	COG1126	abc transporter atp-binding protein
CF58_RS20940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF58_RS20960	COG0551	DNA topoisomerase type I activity
CF58_RS20970	COG0758	DNA mediated transformation
CF58_RS20990	COG0569	domain protein
CF58_RS21000	COG3036	rescue of stalled ribosome
CF58_RS21005	COG0789	Transcriptional regulator
CF58_RS21045	COG0201	protein transport
CF58_RS21135	COG0089	rRNA binding
CF58_RS21210	COG2964	Protein conserved in bacteria
CF58_RS21215	COG0545	Peptidyl-prolyl cis-trans isomerase
CF58_RS21225	COG1047	Peptidyl-prolyl cis-trans
CF58_RS21245	COG0488	(ABC) transporter
CF58_RS21250	COG0429	hydrolase of the alpha beta-hydrolase fold
CF58_RS21260	COG3954	Phosphoribulokinase
CF58_RS21265	COG1765	OsmC-like protein
CF58_RS21275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF58_RS21280	COG1289	transmembrane transporter activity
CF58_RS21285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CF58_RS21290	COG0512	Glutamine amidotransferase of anthranilate synthase
CF58_RS21295	COG2184	nucleotidyltransferase activity
CF58_RS21305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CF58_RS21315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CF58_RS21320	COG2146	nitrite reductase [NAD(P)H] activity
CF58_RS21325	COG2116	formate transmembrane transporter activity
CF58_RS21340	COG0626	cystathionine gamma-synthase activity
CF58_RS21355	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CF58_RS21360	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CF58_RS21365	COG3457	Alanine racemase
CF58_RS21375	COG2188	Transcriptional regulator
CF58_RS21380	COG0180	Tryptophanyl-tRNA synthetase
CF58_RS21390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CF58_RS21395	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CF58_RS21400	COG3266	domain, Protein
CF58_RS21415	COG4796	Type ii and iii secretion system protein
CF58_RS21430	COG3166	PFAM Fimbrial assembly family protein
CF58_RS21435	COG4972	Pilus assembly protein
CF58_RS21440	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CF58_RS21445	COG0494	nUDIX hydrolase
CF58_RS21455	COG1011	Hydrolase
CF58_RS21460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CF58_RS21470	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CF58_RS21495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF58_RS21500	COG2183	response to ionizing radiation
CF58_RS21505	COG1918	ferrous iron import across plasma membrane
CF58_RS21510	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CF58_RS21520	COG5464	transposase or invertase
CF58_RS21540	COG2610	gluconate transmembrane transporter activity
CF58_RS21545	COG1640	4-alpha-glucanotransferase
CF58_RS21550	COG0058	SHG alpha-glucan phosphorylase activity
CF58_RS21565	COG1690	Belongs to the RtcB family
CF58_RS21570	COG4650	regulator
CF58_RS21575	COG1349	DNA-binding transcription factor activity
CF58_RS21590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CF58_RS21615	COG3539	Fimbrial protein
CF58_RS21620	COG3188	usher protein
CF58_RS21625	COG3121	Chaperone
CF58_RS21635	COG0058	SHG alpha-glucan phosphorylase activity
CF58_RS21655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CF58_RS21660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF58_RS21665	COG2095	MarC family integral membrane protein
CF58_RS21670	COG2610	gluconate transmembrane transporter activity
CF58_RS21675	COG3265	gluconokinase activity
CF58_RS21680	COG1609	Transcriptional regulator
CF58_RS21685	COG1741	Belongs to the pirin family
CF58_RS21690	COG0673	inositol 2-dehydrogenase activity
CF58_RS21700	COG1247	-acetyltransferase
CF58_RS21705	COG3157	Type VI secretion system effector, Hcp
CF58_RS21720	COG0405	Gamma-glutamyltransferase
CF58_RS21730	COG0584	glycerophosphoryl diester phosphodiesterase
CF58_RS21745	COG1175	transmembrane transport
CF58_RS21750	COG1653	transport
CF58_RS21760	COG0410	ABC transporter
CF58_RS21765	COG0411	ABC transporter
CF58_RS21770	COG4177	L-phenylalanine transmembrane transporter activity
CF58_RS21775	COG0559	Belongs to the binding-protein-dependent transport system permease family
CF58_RS21780	COG0683	leucine binding
CF58_RS21785	COG0456	acetyltransferase
CF58_RS21795	COG0683	leucine binding
CF58_RS21800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF58_RS21805	COG2177	Part of the ABC transporter FtsEX involved in
CF58_RS21810	COG2884	Cell division ATP-binding protein ftsE
CF58_RS21815	COG0552	protein localization to endoplasmic reticulum
CF58_RS21820	COG0742	ribosomal rna small subunit methyltransferase
CF58_RS21825	COG3776	membrane
CF58_RS21835	COG3714	YhhN family
CF58_RS21850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CF58_RS21865	COG0628	permease
CF58_RS21870	COG2091	lysine biosynthetic process via aminoadipic acid
CF58_RS21875	COG0747	negative chemotaxis
CF58_RS21880	COG0601	transmembrane transport
CF58_RS21905	COG3209	COG3209 Rhs family protein
CF58_RS21925	COG3209	COG3209 Rhs family protein
CF58_RS21935	COG1413	lyase activity
CF58_RS21940	COG3209	COG3209 Rhs family protein
CF58_RS21945	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF58_RS21950	COG5433	transposase activity
CF58_RS21955	COG0842	Transport permease protein
CF58_RS21960	COG0842	Transport permease protein
CF58_RS21960	COG1129	ABC transporter
CF58_RS21965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF58_RS21995	COG2081	HI0933 family
CF58_RS22000	COG0306	phosphate transporter
CF58_RS22010	COG0589	response to stress
CF58_RS22015	COG3104	oligopeptide transport
CF58_RS22025	COG0339	signal peptide processing
CF58_RS22030	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CF58_RS22035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF58_RS22050	COG0640	Transcriptional regulator
CF58_RS22055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CF58_RS22060	COG1393	Belongs to the ArsC family
CF58_RS22080	COG3065	identical protein binding
CF58_RS22085	COG2197	response regulator
CF58_RS22090	COG3720	iron ion transport
CF58_RS22095	COG4771	TonB-dependent receptor
CF58_RS22100	COG4558	Periplasmic binding protein
CF58_RS22110	COG3721	Heme iron utilization protein
CF58_RS22120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF58_RS22130	COG1285	pathogenesis
CF58_RS22145	COG3247	response to pH
CF58_RS22150	COG2771	luxR family
CF58_RS22160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF58_RS22165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF58_RS22170	COG2207	Transcriptional regulator
CF58_RS22175	COG2207	Transcriptional regulator
CF58_RS22180	COG0076	glutamate decarboxylase activity
CF58_RS22185	COG1858	cytochrome C peroxidase
CF58_RS22195	COG2197	response regulator
CF58_RS22200	COG0583	DNA-binding transcription factor activity
CF58_RS22205	COG1295	ribonuclease BN
CF58_RS22210	COG0477	Major facilitator Superfamily
CF58_RS22215	COG2982	Protein involved in outer membrane biogenesis
CF58_RS22220	COG2200	EAL domain
CF58_RS22230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF58_RS22235	COG0612	Peptidase, M16
CF58_RS22245	COG2200	EAL domain
CF58_RS22245	COG2199	diguanylate cyclase activity
CF58_RS22250	COG0457	Tetratricopeptide repeat
CF58_RS22250	COG3118	belongs to the thioredoxin family
CF58_RS22255	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CF58_RS22260	COG1215	transferase activity, transferring glycosyl groups
CF58_RS22265	COG1215	transferase activity, transferring glycosyl groups
CF58_RS22290	COG2194	sulfuric ester hydrolase activity
CF58_RS22310	COG0814	amino acid
CF58_RS22315	COG4608	Belongs to the ABC transporter superfamily
CF58_RS22320	COG0444	Belongs to the ABC transporter superfamily
CF58_RS22325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF58_RS22330	COG0601	transmembrane transport
CF58_RS22340	COG0747	negative chemotaxis
CF58_RS22355	COG2194	sulfuric ester hydrolase activity
CF58_RS22360	COG2223	nitrite transmembrane transporter activity
CF58_RS22365	COG5571	outer membrane autotransporter
CF58_RS22370	COG2818	Glycosylase
CF58_RS22375	COG0456	acetyltransferase
CF58_RS22380	COG0243	molybdopterin cofactor binding
CF58_RS22385	COG2885	chlorophyll binding
CF58_RS22400	COG2944	sequence-specific DNA binding
CF58_RS22405	COG1278	Cold shock
CF58_RS22415	COG2801	Transposase and inactivated derivatives
CF58_RS22420	COG2963	transposase activity
CF58_RS22440	COG3274	enterobacterial common antigen metabolic process
CF58_RS22445	COG4682	membrane
CF58_RS22450	COG4682	membrane
CF58_RS22455	COG1070	Carbohydrate kinase
CF58_RS22465	COG4213	ABC transporter substrate-binding protein
CF58_RS22475	COG4214	carbohydrate transport
CF58_RS22480	COG1609	Transcriptional regulator
CF58_RS22480	COG2207	Transcriptional regulator
CF58_RS22485	COG2992	FlgJ-related protein
CF58_RS22490	COG0366	Alpha amylase catalytic
CF58_RS22495	COG3977	Valine--pyruvate aminotransferase
CF58_RS22505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF58_RS22510	COG1414	Transcriptional regulator
CF58_RS22520	COG2731	YhcH YjgK YiaL family protein
CF58_RS22525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CF58_RS22530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CF58_RS22535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CF58_RS22540	COG1070	Carbohydrate kinase
CF58_RS22545	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CF58_RS22550	COG3623	hexulose-6-phosphate isomerase
CF58_RS22555	COG0235	Class ii aldolase
CF58_RS22565	COG2211	Major facilitator Superfamily
CF58_RS22595	COG1012	belongs to the aldehyde dehydrogenase family
CF58_RS22605	COG1454	alcohol dehydrogenase
CF58_RS22610	COG3276	selenocysteine insertion sequence binding
CF58_RS22620	COG0625	glutathione transferase activity
CF58_RS22640	COG1566	PFAM secretion protein HlyD family protein
CF58_RS22650	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF58_RS22650	COG2213	PTS system mannitol-specific
CF58_RS22660	COG3722	fumarate hydratase activity
CF58_RS22680	COG5295	Hep Hag repeat protein
CF58_RS22685	COG1620	l-lactate permease
CF58_RS22690	COG2186	Transcriptional regulator
CF58_RS22700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CF58_RS22705	COG1045	serine acetyltransferase
CF58_RS22720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF58_RS22725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF58_RS22740	COG4942	peptidase
CF58_RS22745	COG2861	carbohydrate metabolic process
CF58_RS22750	COG1216	Glycosyl transferase, family 2
CF58_RS22760	COG0156	8-amino-7-oxononanoate synthase activity
CF58_RS22770	COG0859	PFAM glycosyl transferase family 9
CF58_RS22775	COG0859	PFAM glycosyl transferase family 9
CF58_RS22790	COG1442	glycosyl transferase family 8
CF58_RS22795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CF58_RS22810	COG0515	serine threonine protein kinase
CF58_RS22815	COG0438	transferase activity, transferring glycosyl groups
CF58_RS22820	COG0859	PFAM glycosyl transferase family 9
CF58_RS22825	COG1519	Transferase
CF58_RS22835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CF58_RS22855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CF58_RS22880	COG1561	YicC-like family, N-terminal region
CF58_RS22885	COG3645	SOS response
CF58_RS22890	COG2860	membrane
CF58_RS22900	COG0194	GDP metabolic process
CF58_RS22910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF58_RS22915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF58_RS22920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CF58_RS22930	COG0786	glutamate:sodium symporter activity
CF58_RS22935	COG2233	PERMEase
CF58_RS22940	COG2982	Protein involved in outer membrane biogenesis
CF58_RS22945	COG1501	Belongs to the glycosyl hydrolase 31 family
CF58_RS22950	COG2211	Major facilitator Superfamily
CF58_RS22960	COG0582	viral genome integration into host DNA
CF58_RS23020	COG2814	Major facilitator Superfamily
CF58_RS23025	COG0697	spore germination
CF58_RS23030	COG1464	Belongs to the NlpA lipoprotein family
CF58_RS23055	COG2252	PERMEase
CF58_RS23065	COG2271	Major facilitator Superfamily
CF58_RS23070	COG2271	Major facilitator Superfamily
CF58_RS23075	COG3851	Histidine kinase
CF58_RS23080	COG2197	response regulator
CF58_RS23100	COG0440	acetolactate synthase activity
CF58_RS23105	COG0028	Belongs to the TPP enzyme family
CF58_RS23130	COG2814	Major facilitator Superfamily
CF58_RS23135	COG0641	radical SAM
CF58_RS23145	COG2149	membrane
CF58_RS23150	COG3119	arylsulfatase activity
CF58_RS23155	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF58_RS23160	COG2207	Transcriptional regulator
CF58_RS23175	COG2188	Transcriptional regulator
CF58_RS23200	COG5645	(Lipo)protein
CF58_RS23205	COG0823	Involved in the tonB-independent uptake of proteins
CF58_RS23215	COG2271	Major facilitator Superfamily
CF58_RS23225	COG0800	Aldolase
CF58_RS23230	COG3734	2-keto-3-deoxy-galactonokinase
CF58_RS23235	COG2186	Transcriptional regulator
CF58_RS23245	COG0561	phosphatase activity
CF58_RS23250	COG3753	Protein conserved in bacteria
CF58_RS23255	COG0187	DNA topoisomerase II activity
CF58_RS23265	COG0592	DNA-directed DNA polymerase activity
CF58_RS23315	COG0814	amino acid
CF58_RS23330	COG2091	lysine biosynthetic process via aminoadipic acid
CF58_RS23335	COG0431	NADPH-dependent FMN reductase
CF58_RS23340	COG2252	PERMEase
CF58_RS23345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF58_RS23380	COG0704	Plays a role in the regulation of phosphate uptake
CF58_RS23385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CF58_RS23390	COG0581	inorganic phosphate transmembrane transporter activity
CF58_RS23395	COG0573	inorganic phosphate transmembrane transporter activity
CF58_RS23400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CF58_RS23425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CF58_RS23475	COG3312	ion transport
CF58_RS23490	COG0716	FMN binding
CF58_RS23495	COG1522	sequence-specific DNA binding
CF58_RS23525	COG1129	ABC transporter
CF58_RS23530	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF58_RS23535	COG1879	ABC-type sugar transport system periplasmic component
CF58_RS23540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF58_RS23545	COG1609	Transcriptional regulator
CF58_RS23550	COG0477	Major facilitator Superfamily
CF58_RS23555	COG2186	Transcriptional regulator
CF58_RS23595	COG3085	chromosome segregation
CF58_RS23600	COG0606	chelatase, subunit chli
CF58_RS23615	COG3978	acetolactate synthase activity
CF58_RS23620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CF58_RS23630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF58_RS23635	COG0583	DNA-binding transcription factor activity
CF58_RS23645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF58_RS23650	COG3692	DNA binding
CF58_RS23655	COG0210	DNA helicase
CF58_RS23670	COG3118	belongs to the thioredoxin family
CF58_RS23680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CF58_RS23695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CF58_RS23700	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF58_RS23705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CF58_RS23710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CF58_RS23715	COG0456	acetyltransferase
CF58_RS23720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CF58_RS23725	COG2244	polysaccharide biosynthetic process
CF58_RS23745	COG1113	amino acid transport
CF58_RS23770	COG0641	radical SAM
CF58_RS23775	COG3119	arylsulfatase activity
CF58_RS23780	COG3071	HemY protein
CF58_RS23785	COG2959	enzyme of heme biosynthesis
CF58_RS23790	COG1587	Uroporphyrinogen-III synthase
CF58_RS23800	COG3072	Adenylate cyclase
CF58_RS23810	COG5567	small periplasmic lipoprotein
CF58_RS23820	COG3159	Protein conserved in bacteria
CF58_RS23830	COG1011	Hydrolase
CF58_RS23835	COG0210	DNA helicase
CF58_RS23840	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CF58_RS23845	COG3698	Phosphodiester glycosidase
CF58_RS23855	COG0598	Magnesium transport protein CorA
CF58_RS23870	COG2962	Rard protein
CF58_RS23875	COG2050	protein possibly involved in aromatic compounds catabolism
CF58_RS23880	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CF58_RS23885	COG0514	ATP-dependent DNA helicase (RecQ)
CF58_RS23890	COG1280	lysine exporter protein (LysE YggA)
CF58_RS23895	COG1280	lysine exporter protein (LysE YggA)
CF58_RS23900	COG2267	carboxylic ester hydrolase activity
CF58_RS23905	COG0561	phosphatase activity
CF58_RS23910	COG0697	spore germination
CF58_RS23915	COG0583	DNA-binding transcription factor activity
CF58_RS23920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CF58_RS23935	COG3157	Type VI secretion system effector, Hcp
CF58_RS23940	COG0412	Dienelactone hydrolase
CF58_RS23945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CF58_RS23950	COG1322	Protein conserved in bacteria
CF58_RS23960	COG3165	ubiquinone biosynthetic process from chorismate
CF58_RS23970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF58_RS23975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF58_RS23980	COG0805	protein transport
CF58_RS23990	COG0250	Participates in transcription elongation, termination and antitermination
CF58_RS23995	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CF58_RS24000	COG0543	2 iron, 2 sulfur cluster binding
CF58_RS24020	COG1739	Uncharacterized protein family UPF0029
CF58_RS24025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CF58_RS24030	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CF58_RS24070	COG1763	Mo-molybdopterin cofactor biosynthetic process
CF58_RS24120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF58_RS24165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF58_RS24180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF58_RS24225	COG0741	lytic transglycosylase activity
CF58_RS24240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF58_RS24275	COG0741	lytic transglycosylase activity
CF58_RS24335	COG0741	lytic transglycosylase activity
CF58_RS24385	COG0741	lytic transglycosylase activity
CF58_RS24405	COG0564	pseudouridine synthase activity
CF58_RS24415	COG0542	response to heat
CF58_RS24450	COG1763	Mo-molybdopterin cofactor biosynthetic process
CF58_RS24455	COG0746	molybdenum cofactor guanylyltransferase activity
CF58_RS24460	COG3084	Protein conserved in bacteria
CF58_RS24470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF58_RS24505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF58_RS24520	COG0741	lytic transglycosylase activity
CF58_RS24610	COG3209	COG3209 Rhs family protein
CF58_RS24615	COG5433	transposase activity
CF58_RS24710	COG4917	ethanolamine utilization protein