locus-tag	class	description
CF59_RS00025	COG1763	Mo-molybdopterin cofactor biosynthetic process
CF59_RS00030	COG0746	molybdenum cofactor guanylyltransferase activity
CF59_RS00035	COG3084	Protein conserved in bacteria
CF59_RS00040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CF59_RS00045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF59_RS00050	COG5339	Protein conserved in bacteria
CF59_RS00055	COG0204	Acyl-transferase
CF59_RS00065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CF59_RS00065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CF59_RS00080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF59_RS00090	COG2204	response regulator
CF59_RS00095	COG3852	Histidine kinase
CF59_RS00100	COG0174	glutamine synthetase
CF59_RS00110	COG1217	gtp-binding protein TYPA
CF59_RS00115	COG2188	Transcriptional regulator
CF59_RS00120	COG1082	Xylose isomerase domain protein TIM barrel
CF59_RS00125	COG2271	Major facilitator Superfamily
CF59_RS00130	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF59_RS00135	COG2211	Major facilitator Superfamily
CF59_RS00140	COG2211	Major facilitator Superfamily
CF59_RS00145	COG1501	Belongs to the glycosyl hydrolase 31 family
CF59_RS00155	COG2017	converts alpha-aldose to the beta-anomer
CF59_RS00160	COG2942	2-epimerase
CF59_RS00165	COG3684	Belongs to the aldolase LacD family
CF59_RS00170	COG2084	Dehydrogenase
CF59_RS00175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF59_RS00180	COG1349	DNA-binding transcription factor activity
CF59_RS00185	COG1011	Hydrolase
CF59_RS00200	COG0456	acetyltransferase
CF59_RS00215	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF59_RS00225	COG2864	formate dehydrogenase
CF59_RS00230	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS00235	COG3383	formate dehydrogenase (NAD+) activity
CF59_RS00235	COG0243	molybdopterin cofactor binding
CF59_RS00240	COG0243	molybdopterin cofactor binding
CF59_RS00240	COG3383	formate dehydrogenase (NAD+) activity
CF59_RS00255	COG3711	transcriptional antiterminator
CF59_RS00255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS00260	COG1363	Peptidase, m42
CF59_RS00265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS00265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS00270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS00320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CF59_RS00335	COG2258	MOSC domain
CF59_RS00350	COG2801	Transposase and inactivated derivatives
CF59_RS00355	COG2205	protein histidine kinase activity
CF59_RS00360	COG0745	RESPONSE REGULATOR receiver
CF59_RS00365	COG3678	ATP-independent chaperone mediated protein folding
CF59_RS00380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CF59_RS00400	COG3152	Membrane
CF59_RS00405	COG3691	Protein conserved in bacteria
CF59_RS00410	COG0589	response to stress
CF59_RS00420	COG1494	fructose-1,6-bisphosphatase
CF59_RS00430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CF59_RS00445	COG1575	Belongs to the MenA family. Type 1 subfamily
CF59_RS00460	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF59_RS00465	COG1609	Transcriptional regulator
CF59_RS00470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CF59_RS00485	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF59_RS00495	COG5433	transposase activity
CF59_RS00505	COG3209	COG3209 Rhs family protein
CF59_RS00530	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CF59_RS00540	COG0626	cystathionine gamma-synthase activity
CF59_RS00545	COG0527	aspartate kinase activity
CF59_RS00545	COG0460	homoserine dehydrogenase
CF59_RS00555	COG0737	Belongs to the 5'-nucleotidase family
CF59_RS00560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CF59_RS00570	COG0697	spore germination
CF59_RS00575	COG3738	Protein conserved in bacteria
CF59_RS00580	COG0371	Dehydrogenase
CF59_RS00585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF59_RS00590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF59_RS00590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS00590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS00595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS00600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS00605	COG1882	Formate acetyltransferase
CF59_RS00610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF59_RS00615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS00620	COG2207	Transcriptional regulator
CF59_RS00625	COG2194	sulfuric ester hydrolase activity
CF59_RS00640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CF59_RS00655	COG0583	DNA-binding transcription factor activity
CF59_RS00680	COG4206	TonB-dependent receptor
CF59_RS00715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CF59_RS00720	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CF59_RS00720	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CF59_RS00760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF59_RS00765	COG0250	Participates in transcription elongation, termination and antitermination
CF59_RS00800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CF59_RS00810	COG2104	thiamine diphosphate biosynthetic process
CF59_RS00815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CF59_RS00850	COG3068	Protein conserved in bacteria
CF59_RS00865	COG3678	ATP-independent chaperone mediated protein folding
CF59_RS00870	COG4191	Histidine kinase
CF59_RS00875	COG2204	response regulator
CF59_RS00880	COG0151	Belongs to the GarS family
CF59_RS00930	COG0456	acetyltransferase
CF59_RS00940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CF59_RS00945	COG2224	Isocitrate lyase
CF59_RS00960	COG1414	Transcriptional regulator
CF59_RS00965	COG0646	methionine synthase
CF59_RS00965	COG1410	methionine synthase
CF59_RS00980	COG1283	sodium-dependent phosphate transmembrane transporter activity
CF59_RS01030	COG1187	pseudouridine synthase activity
CF59_RS01040	COG0527	aspartate kinase activity
CF59_RS01065	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF59_RS01085	COG2814	Major facilitator Superfamily
CF59_RS01085	COG0477	Major facilitator Superfamily
CF59_RS01090	COG3833	ABC-type maltose transport systems, permease component
CF59_RS01095	COG1175	transmembrane transport
CF59_RS01100	COG2182	Extracellular solute-binding protein
CF59_RS01110	COG3842	ATPase activity
CF59_RS01125	COG1357	PFAM Pentapeptide repeats (8 copies)
CF59_RS01145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CF59_RS01155	COG0534	Mate efflux family protein
CF59_RS01160	COG3237	CsbD-like
CF59_RS01165	COG0735	belongs to the Fur family
CF59_RS01180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF59_RS01190	COG0604	alcohol dehydrogenase
CF59_RS01195	COG0305	Participates in initiation and elongation during chromosome replication
CF59_RS01200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CF59_RS01205	COG1448	Aminotransferase
CF59_RS01215	COG3700	Belongs to the class B bacterial acid phosphatase family
CF59_RS01220	COG0432	Pfam Uncharacterised protein family UPF0047
CF59_RS01225	COG2315	Protein conserved in bacteria
CF59_RS01230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CF59_RS01235	COG0629	single-stranded DNA binding
CF59_RS01245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CF59_RS01250	COG2207	Transcriptional regulator
CF59_RS01255	COG0789	Transcriptional regulator
CF59_RS01260	COG2252	PERMEase
CF59_RS01265	COG0025	NhaP-type Na H and K H
CF59_RS01270	COG1357	PFAM Pentapeptide repeats (8 copies)
CF59_RS01280	COG3162	membrane
CF59_RS01285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF59_RS01295	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CF59_RS01300	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS01305	COG3301	Polysulphide reductase, NrfD
CF59_RS01310	COG1138	Cytochrome C-type biogenesis protein
CF59_RS01315	COG3088	subunit of a heme lyase
CF59_RS01320	COG4235	cytochrome complex assembly
CF59_RS01325	COG1301	dicarboxylic acid transport
CF59_RS01330	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF59_RS01335	COG3383	formate dehydrogenase (NAD+) activity
CF59_RS01340	COG3383	formate dehydrogenase (NAD+) activity
CF59_RS01350	COG1289	transmembrane transporter activity
CF59_RS01355	COG1566	PFAM secretion protein HlyD family protein
CF59_RS01365	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CF59_RS01370	COG1940	carbohydrate kinase activity
CF59_RS01375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CF59_RS01380	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF59_RS01385	COG1129	ABC transporter
CF59_RS01390	COG1879	ABC-type sugar transport system periplasmic component
CF59_RS01395	COG1737	Transcriptional regulator
CF59_RS01400	COG0698	ribose 5-phosphate isomerase
CF59_RS01410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CF59_RS01415	COG0456	acetyltransferase
CF59_RS01425	COG3454	Phosphonate metabolism
CF59_RS01430	COG4778	phosphonate C-P lyase system protein PhnL
CF59_RS01435	COG4107	phosphonate C-P lyase system protein PhnK
CF59_RS01440	COG3627	carbon phosphorus lyase activity
CF59_RS01445	COG3626	phosphonate metabolism
CF59_RS01450	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CF59_RS01455	COG3624	Phosphonate C-P lyase system protein PhnG
CF59_RS01460	COG2188	Transcriptional regulator
CF59_RS01465	COG3639	organic phosphonate transmembrane transporter activity
CF59_RS01470	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CF59_RS01480	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CF59_RS01485	COG2824	Alkylphosphonate utilization operon protein PhnA
CF59_RS01500	COG0477	Major facilitator Superfamily
CF59_RS01510	COG0642	Histidine kinase
CF59_RS01515	COG0745	RESPONSE REGULATOR receiver
CF59_RS01520	COG2194	sulfuric ester hydrolase activity
CF59_RS01525	COG0531	amino acid
CF59_RS01530	COG2207	Transcriptional regulator
CF59_RS01535	COG1982	Orn Lys Arg decarboxylase major
CF59_RS01540	COG2169	Transcriptional regulator
CF59_RS01550	COG1486	melibiose metabolic process
CF59_RS01555	COG2211	Major facilitator Superfamily
CF59_RS01565	COG3647	Membrane
CF59_RS01570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF59_RS01570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF59_RS01575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF59_RS01585	COG4565	transcriptional regulatory protein
CF59_RS01590	COG3290	protein histidine kinase activity
CF59_RS01595	COG3592	Divergent 4Fe-4S mono-cluster
CF59_RS01600	COG2388	GCN5-related N-acetyl-transferase
CF59_RS01615	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CF59_RS01620	COG3104	oligopeptide transport
CF59_RS01625	COG1982	Orn Lys Arg decarboxylase major
CF59_RS01630	COG0531	amino acid
CF59_RS01635	COG3710	Transcriptional regulator
CF59_RS01645	COG1309	transcriptional regulator
CF59_RS01650	COG4232	protein-disulfide reductase activity
CF59_RS01660	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF59_RS01665	COG1027	Aspartate ammonia-lyase
CF59_RS01670	COG3030	protein affecting phage T7 exclusion by the F plasmid
CF59_RS01675	COG0531	amino acid
CF59_RS01700	COG1509	lysine 2,3-aminomutase activity
CF59_RS01710	COG5510	response to toxic substance
CF59_RS01715	COG5510	response to toxic substance
CF59_RS01720	COG2076	Multidrug Resistance protein
CF59_RS01725	COG3040	lipid binding
CF59_RS01730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF59_RS01745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CF59_RS01750	COG1053	succinate dehydrogenase
CF59_RS01760	COG0531	amino acid
CF59_RS01765	COG3264	Mechanosensitive ion channel
CF59_RS01765	COG1511	domain protein
CF59_RS01805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CF59_RS01805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CF59_RS01810	COG0802	atpase or kinase
CF59_RS01815	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF59_RS01835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CF59_RS01840	COG0330	HflC and HflK could
CF59_RS01845	COG0330	HflC and HflK could
CF59_RS01850	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CF59_RS01865	COG0557	exoribonuclease II activity
CF59_RS01870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF59_RS01875	COG3789	protein conserved in bacteria
CF59_RS01880	COG1842	Phage shock protein A
CF59_RS01890	COG3766	membrane
CF59_RS01895	COG5463	Belongs to the UPF0441 family
CF59_RS01900	COG0754	glutathionylspermidine amidase activity
CF59_RS01905	COG1960	acyl-CoA dehydrogenase activity
CF59_RS01915	COG3650	response to hydrogen peroxide
CF59_RS01920	COG1073	alpha beta
CF59_RS01935	COG3037	sugar-specific permease SgaT UlaA
CF59_RS01980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CF59_RS01995	COG1309	transcriptional regulator
CF59_RS02000	COG3061	Opacity-associated protein A
CF59_RS02005	COG0545	Peptidyl-prolyl cis-trans isomerase
CF59_RS02010	COG1113	amino acid transport
CF59_RS02020	COG0697	spore germination
CF59_RS02025	COG0702	epimerase
CF59_RS02030	COG1733	regulation of RNA biosynthetic process
CF59_RS02035	COG0737	Belongs to the 5'-nucleotidase family
CF59_RS02040	COG1218	3'(2'),5'-bisphosphate nucleotidase
CF59_RS02050	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CF59_RS02060	COG1253	flavin adenine dinucleotide binding
CF59_RS02075	COG0729	surface antigen
CF59_RS02080	COG2911	Protein conserved in bacteria
CF59_RS02085	COG2105	PFAM AIG2 family protein
CF59_RS02090	COG2336	PFAM SpoVT AbrB
CF59_RS02095	COG2337	Toxic component of a toxin-antitoxin (TA) module
CF59_RS02100	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CF59_RS02105	COG1879	ABC-type sugar transport system periplasmic component
CF59_RS02110	COG1129	ABC transporter
CF59_RS02115	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF59_RS02120	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF59_RS02130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CF59_RS02140	COG0312	modulator of DNA gyrase
CF59_RS02145	COG3783	Cytochrome b(562)
CF59_RS02150	COG3077	Addiction module antitoxin, RelB DinJ family
CF59_RS02155	COG2026	Addiction module toxin, RelE StbE family
CF59_RS02160	COG0602	queuosine metabolic process
CF59_RS02170	COG1328	CTP reductase activity
CF59_RS02175	COG0366	Alpha amylase catalytic
CF59_RS02180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS02180	COG1263	PTS System
CF59_RS02185	COG1609	Transcriptional regulator
CF59_RS02190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CF59_RS02195	COG0251	oxidation-reduction process
CF59_RS02220	COG0251	oxidation-reduction process
CF59_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS02230	COG1309	transcriptional regulator
CF59_RS02235	COG2731	YhcH YjgK YiaL family protein
CF59_RS02250	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CF59_RS02255	COG0456	acetyltransferase
CF59_RS02260	COG4269	membrane
CF59_RS02265	COG0525	valine-tRNA ligase activity
CF59_RS02270	COG2927	DNA polymerase III (CHI subunit)
CF59_RS02280	COG0795	lipopolysaccharide-transporting ATPase activity
CF59_RS02285	COG0795	lipopolysaccharide-transporting ATPase activity
CF59_RS02290	COG0433	COG0433 Predicted ATPase
CF59_RS02295	COG1064	alcohol dehydrogenase
CF59_RS02305	COG0582	viral genome integration into host DNA
CF59_RS02310	COG2801	Transposase and inactivated derivatives
CF59_RS02315	COG2963	transposase activity
CF59_RS02370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CF59_RS02415	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF59_RS02430	COG0582	viral genome integration into host DNA
CF59_RS02435	COG4974	Belongs to the 'phage' integrase family
CF59_RS02450	COG3539	Fimbrial protein
CF59_RS02455	COG3121	Chaperone
CF59_RS02460	COG3188	usher protein
CF59_RS02465	COG3539	Fimbrial protein
CF59_RS02470	COG3539	Fimbrial protein
CF59_RS02475	COG3539	Fimbrial protein
CF59_RS02480	COG2610	gluconate transmembrane transporter activity
CF59_RS02495	COG0246	Mannitol dehydrogenase
CF59_RS02505	COG2186	Transcriptional regulator
CF59_RS02530	COG0583	DNA-binding transcription factor activity
CF59_RS02535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF59_RS02540	COG0700	Nucleoside recognition
CF59_RS02545	COG3366	ferrous iron transmembrane transporter activity
CF59_RS02555	COG1470	cell adhesion involved in biofilm formation
CF59_RS02555	COG1388	LysM domain
CF59_RS02560	COG0477	Major facilitator Superfamily
CF59_RS02565	COG3204	pilus organization
CF59_RS02580	COG1924	4 iron, 4 sulfur cluster binding
CF59_RS02585	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CF59_RS02590	COG2733	membrane
CF59_RS02595	COG2814	Major facilitator Superfamily
CF59_RS02605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF59_RS02610	COG5457	Domain of unknown function (DUF1127)
CF59_RS02625	COG0732	type I restriction modification DNA specificity domain
CF59_RS02650	COG0523	cobalamin synthesis protein
CF59_RS02655	COG2879	small protein
CF59_RS02660	COG1966	Carbon starvation protein
CF59_RS02670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CF59_RS02675	COG2368	4-hydroxyphenylacetate
CF59_RS02680	COG1234	tRNA 3'-trailer cleavage
CF59_RS02700	COG3971	2-oxopent-4-enoate hydratase activity
CF59_RS02710	COG3384	dioxygenase
CF59_RS02715	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS02720	COG0179	Fumarylacetoacetate (FAA) hydrolase
CF59_RS02725	COG1846	Transcriptional regulator
CF59_RS02730	COG0840	transmembrane signaling receptor activity
CF59_RS02735	COG2271	Major facilitator Superfamily
CF59_RS02740	COG1802	Transcriptional regulator
CF59_RS02745	COG1063	alcohol dehydrogenase
CF59_RS02760	COG1484	DNA-dependent DNA replication
CF59_RS02775	COG2966	Psort location CytoplasmicMembrane, score
CF59_RS02780	COG2197	response regulator
CF59_RS02785	COG2197	response regulator
CF59_RS02790	COG4114	ferric iron reductase
CF59_RS02825	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CF59_RS02830	COG0456	acetyltransferase
CF59_RS02835	COG1011	Hydrolase
CF59_RS02845	COG2823	Periplasmic or secreted lipoprotein
CF59_RS02855	COG4667	esterase of the alpha-beta hydrolase superfamily
CF59_RS02860	COG0084	hydrolase, TatD family'
CF59_RS02865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF59_RS02870	COG1328	CTP reductase activity
CF59_RS02910	COG3726	membrane protein affecting hemolysin expression
CF59_RS02915	COG0560	Phosphoserine phosphatase
CF59_RS02920	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CF59_RS02925	COG3172	ATPase kinase involved in NAD metabolism
CF59_RS02925	COG1056	cytidyltransferase-related domain
CF59_RS02960	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS02970	COG0583	DNA-binding transcription factor activity
CF59_RS02975	COG0488	(ABC) transporter
CF59_RS02980	COG0741	lytic transglycosylase activity
CF59_RS03000	COG2207	Transcriptional regulator
CF59_RS03000	COG3708	Transcriptional regulator
CF59_RS03005	COG3045	CreA protein
CF59_RS03010	COG0745	RESPONSE REGULATOR receiver
CF59_RS03020	COG4452	Inner membrane protein CreD
CF59_RS03025	COG0745	RESPONSE REGULATOR receiver
CF59_RS03035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CF59_RS03045	COG0460	homoserine dehydrogenase
CF59_RS03045	COG0527	aspartate kinase activity
CF59_RS03055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CF59_RS03075	COG1115	amino acid carrier protein
CF59_RS03085	COG0521	Mo-molybdopterin cofactor biosynthetic process
CF59_RS03090	COG1584	GPR1 FUN34 yaaH family protein
CF59_RS03095	COG4735	regulation of single-species biofilm formation
CF59_RS03125	COG3119	arylsulfatase activity
CF59_RS03140	COG0583	DNA-binding transcription factor activity
CF59_RS03150	COG3188	usher protein
CF59_RS03155	COG3121	Chaperone
CF59_RS03180	COG0196	riboflavin kinase activity
CF59_RS03195	COG1047	Peptidyl-prolyl cis-trans
CF59_RS03225	COG0505	Belongs to the CarA family
CF59_RS03230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CF59_RS03285	COG0644	oxidoreductase
CF59_RS03290	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF59_RS03295	COG2271	Major facilitator Superfamily
CF59_RS03310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CF59_RS03335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF59_RS03340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF59_RS03345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CF59_RS03350	COG1357	PFAM Pentapeptide repeats (8 copies)
CF59_RS03355	COG0564	pseudouridine synthase activity
CF59_RS03365	COG0417	DNA replication proofreading
CF59_RS03370	COG0235	Class ii aldolase
CF59_RS03385	COG4977	sequence-specific DNA binding
CF59_RS03390	COG0586	Pfam SNARE associated Golgi protein
CF59_RS03400	COG1178	ABC-type Fe3 transport system permease component
CF59_RS03405	COG4143	(ABC) transporter
CF59_RS03435	COG0473	3-isopropylmalate dehydrogenase activity
CF59_RS03450	COG0583	DNA-binding transcription factor activity
CF59_RS03455	COG0028	Belongs to the TPP enzyme family
CF59_RS03460	COG0440	acetolactate synthase activity
CF59_RS03470	COG1609	Transcriptional regulator
CF59_RS03485	COG3116	cell division
CF59_RS03490	COG0768	penicillin binding
CF59_RS03495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CF59_RS03500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CF59_RS03515	COG0772	Belongs to the SEDS family
CF59_RS03530	COG1181	Belongs to the D-alanine--D-alanine ligase family
CF59_RS03535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CF59_RS03540	COG0849	cell division
CF59_RS03545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CF59_RS03565	COG0494	nUDIX hydrolase
CF59_RS03585	COG0237	dephospho-CoA kinase activity
CF59_RS03595	COG1459	type II secretion system
CF59_RS03600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF59_RS03605	COG4969	Belongs to the N-Me-Phe pilin family
CF59_RS03615	COG0157	Belongs to the NadC ModD family
CF59_RS03620	COG3023	N-Acetylmuramoyl-L-alanine amidase
CF59_RS03625	COG3725	Membrane protein required for beta-lactamase induction
CF59_RS03630	COG1113	amino acid transport
CF59_RS03635	COG2186	Transcriptional regulator
CF59_RS03640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CF59_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF59_RS03650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF59_RS03655	COG3064	Membrane
CF59_RS03660	COG1049	propionate catabolic process, 2-methylcitrate cycle
CF59_RS03685	COG2132	Multicopper oxidase
CF59_RS03690	COG4993	Dehydrogenase
CF59_RS03695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CF59_RS03700	COG0288	reversible hydration of carbon dioxide
CF59_RS03705	COG1131	(ABC) transporter
CF59_RS03710	COG0842	Transport permease protein
CF59_RS03715	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS03720	COG0726	polysaccharide deacetylase
CF59_RS03730	COG5464	transposase or invertase
CF59_RS03750	COG3539	Fimbrial protein
CF59_RS03755	COG3539	Fimbrial protein
CF59_RS03760	COG3539	Fimbrial protein
CF59_RS03765	COG3188	usher protein
CF59_RS03770	COG3121	Chaperone
CF59_RS03775	COG3539	Fimbrial protein
CF59_RS03780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CF59_RS03785	COG0617	tRNA 3'-terminal CCA addition
CF59_RS03790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CF59_RS03795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CF59_RS03805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CF59_RS03810	COG1643	Atp-dependent helicase
CF59_RS03815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CF59_RS03820	COG4774	siderophore transport
CF59_RS03825	COG1120	ATPase activity
CF59_RS03830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF59_RS03835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF59_RS03855	COG2860	membrane
CF59_RS03860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF59_RS03875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF59_RS03880	COG3835	regulator
CF59_RS03900	COG0024	Methionine aminopeptidase
CF59_RS03925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CF59_RS03930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CF59_RS03935	COG0575	Belongs to the CDS family
CF59_RS03940	COG0750	zinc metalloprotease
CF59_RS03950	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CF59_RS03955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CF59_RS03975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CF59_RS03980	COG0587	DNA-directed DNA polymerase activity
CF59_RS03990	COG1982	Orn Lys Arg decarboxylase major
CF59_RS03995	COG0346	lactoylglutathione lyase activity
CF59_RS04000	COG0037	tRNA processing
CF59_RS04005	COG4568	rho-dependent transcription termination
CF59_RS04015	COG4681	YaeQ
CF59_RS04020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CF59_RS04025	COG3015	lipoprotein NlpE involved in copper resistance
CF59_RS04030	COG0791	NLP P60 protein
CF59_RS04040	COG1720	tRNA m6t6A37 methyltransferase activity
CF59_RS04050	COG1464	Belongs to the NlpA lipoprotein family
CF59_RS04055	COG2011	ABC-type metal ion transport system permease component
CF59_RS04060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CF59_RS04065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CF59_RS04100	COG0656	L-ascorbic acid biosynthetic process
CF59_RS04105	COG0583	DNA-binding transcription factor activity
CF59_RS04115	COG2226	methyltransferase
CF59_RS04120	COG1388	LysM domain
CF59_RS04120	COG0741	lytic transglycosylase activity
CF59_RS04130	COG2226	methyltransferase
CF59_RS04140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF59_RS04160	COG4104	PAAR repeat-containing protein
CF59_RS04165	COG3157	Type VI secretion system effector, Hcp
CF59_RS04265	COG3209	COG3209 Rhs family protein
CF59_RS04275	COG5433	transposase activity
CF59_RS04280	COG3328	transposase activity
CF59_RS04285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF59_RS04295	COG1960	acyl-CoA dehydrogenase activity
CF59_RS04305	COG0121	glutamine amidotransferase
CF59_RS04310	COG3034	peptidoglycan biosynthetic process
CF59_RS04315	COG0791	NLP P60 protein
CF59_RS04345	COG2161	toxin-antitoxin pair type II binding
CF59_RS04355	COG0454	-acetyltransferase
CF59_RS04360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CF59_RS04365	COG2195	Cleaves the N-terminal amino acid of tripeptides
CF59_RS04385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF59_RS04405	COG0582	viral genome integration into host DNA
CF59_RS04410	COG3423	Transcriptional regulator
CF59_RS04435	COG0583	DNA-binding transcription factor activity
CF59_RS04450	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CF59_RS04455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF59_RS04460	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF59_RS04465	COG2080	2 iron, 2 sulfur cluster binding
CF59_RS04470	COG3477	response to acidic pH
CF59_RS04475	COG0727	PFAM Uncharacterised protein family (UPF0153)
CF59_RS04525	COG1902	pentaerythritol trinitrate reductase activity
CF59_RS04530	COG1073	alpha beta
CF59_RS04535	COG0583	DNA-binding transcription factor activity
CF59_RS04545	COG0667	Aldo Keto reductase
CF59_RS04550	COG0656	L-ascorbic acid biosynthetic process
CF59_RS04555	COG1388	LysM domain
CF59_RS04560	COG2207	Transcriptional regulator
CF59_RS04560	COG3708	Transcriptional regulator
CF59_RS04565	COG0656	L-ascorbic acid biosynthetic process
CF59_RS04570	COG3059	membrane
CF59_RS04580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF59_RS04585	COG2207	Transcriptional regulator
CF59_RS04590	COG0247	lactate metabolic process
CF59_RS04595	COG1139	Iron-sulfur cluster binding protein
CF59_RS04600	COG1556	Lactate utilization protein
CF59_RS04630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CF59_RS04640	COG2200	EAL domain
CF59_RS04640	COG2771	luxR family
CF59_RS04645	COG0583	DNA-binding transcription factor activity
CF59_RS04655	COG0666	response to abiotic stimulus
CF59_RS04665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF59_RS04670	COG1304	FMN binding
CF59_RS04675	COG0549	Belongs to the carbamate kinase family
CF59_RS04680	COG0402	S-adenosylhomocysteine deaminase activity
CF59_RS04690	COG1879	ABC-type sugar transport system periplasmic component
CF59_RS04695	COG1129	ABC transporter
CF59_RS04700	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF59_RS04710	COG1064	alcohol dehydrogenase
CF59_RS04725	COG1280	lysine exporter protein (LysE YggA)
CF59_RS04735	COG3829	transcription factor binding
CF59_RS04740	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CF59_RS04745	COG0372	Belongs to the citrate synthase family
CF59_RS04750	COG2079	MmgE PrpD family protein
CF59_RS04755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF59_RS04760	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CF59_RS04765	COG0402	S-adenosylhomocysteine deaminase activity
CF59_RS04770	COG0583	DNA-binding transcription factor activity
CF59_RS04775	COG0288	reversible hydration of carbon dioxide
CF59_RS04785	COG2807	transmembrane transport
CF59_RS04790	COG0110	maltose O-acetyltransferase activity
CF59_RS04795	COG2223	nitrite transmembrane transporter activity
CF59_RS04805	COG1609	Transcriptional regulator
CF59_RS04810	COG1414	Transcriptional regulator
CF59_RS04845	COG2814	Major facilitator Superfamily
CF59_RS04850	COG3122	Protein conserved in bacteria
CF59_RS04880	COG1215	transferase activity, transferring glycosyl groups
CF59_RS04885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CF59_RS04890	COG4521	taurine ABC transporter
CF59_RS04895	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CF59_RS04900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CF59_RS04905	COG2175	clavaminate synthase activity
CF59_RS04910	COG0113	porphobilinogen synthase activity
CF59_RS04915	COG3468	outer membrane autotransporter barrel domain protein
CF59_RS04920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF59_RS04925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF59_RS04935	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CF59_RS04955	COG1181	Belongs to the D-alanine--D-alanine ligase family
CF59_RS04970	COG1785	Belongs to the alkaline phosphatase family
CF59_RS04980	COG3706	GGDEF domain
CF59_RS04985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CF59_RS05010	COG4126	flavin adenine dinucleotide binding
CF59_RS05030	COG1940	carbohydrate kinase activity
CF59_RS05035	COG2814	Major facilitator Superfamily
CF59_RS05040	COG0419	ATPase involved in DNA repair
CF59_RS05045	COG0420	3'-5' exonuclease activity
CF59_RS05050	COG0745	RESPONSE REGULATOR receiver
CF59_RS05055	COG5002	protein histidine kinase activity
CF59_RS05060	COG1114	Component of the transport system for branched-chain amino acids
CF59_RS05065	COG1113	amino acid transport
CF59_RS05070	COG0366	Alpha amylase catalytic
CF59_RS05095	COG1862	Preprotein translocase
CF59_RS05100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF59_RS05105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF59_RS05110	COG1403	HNH endonuclease
CF59_RS05120	COG3248	Nucleoside-binding outer membrane protein
CF59_RS05125	COG4238	major outer membrane lipoprotein
CF59_RS05140	COG0675	Transposase, IS605 OrfB family
CF59_RS05145	COG4238	major outer membrane lipoprotein
CF59_RS05155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF59_RS05155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF59_RS05170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CF59_RS05175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CF59_RS05185	COG0667	Aldo Keto reductase
CF59_RS05195	COG0142	geranyltranstransferase activity
CF59_RS05210	COG0693	protein deglycase activity
CF59_RS05215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CF59_RS05225	COG2814	Major facilitator Superfamily
CF59_RS05235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CF59_RS05240	COG1845	cytochrome c oxidase, subunit III
CF59_RS05245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CF59_RS05250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CF59_RS05255	COG2223	nitrite transmembrane transporter activity
CF59_RS05260	COG3056	Lipoprotein
CF59_RS05265	COG0271	Belongs to the BolA IbaG family
CF59_RS05290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CF59_RS05295	COG0776	regulation of translation
CF59_RS05300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF59_RS05305	COG1555	photosystem II stabilization
CF59_RS05310	COG0824	Thioesterase
CF59_RS05320	COG4533	DNA binding
CF59_RS05330	COG1522	sequence-specific DNA binding
CF59_RS05335	COG1132	(ABC) transporter
CF59_RS05340	COG1132	(ABC) transporter
CF59_RS05345	COG0347	Belongs to the P(II) protein family
CF59_RS05350	COG0004	ammonium transporteR
CF59_RS05355	COG1946	Acyl-CoA thioesterase
CF59_RS05360	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CF59_RS05365	COG3695	enzyme binding
CF59_RS05370	COG5507	3-demethylubiquinone-9 3-methyltransferase
CF59_RS05375	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CF59_RS05385	COG0110	maltose O-acetyltransferase activity
CF59_RS05400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF59_RS05405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF59_RS05410	COG1309	transcriptional regulator
CF59_RS05415	COG3264	Mechanosensitive ion channel
CF59_RS05415	COG1196	nuclear chromosome segregation
CF59_RS05425	COG3923	Primosomal replication protein n
CF59_RS05430	COG2832	Protein of unknown function (DUF454)
CF59_RS05440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CF59_RS05475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF59_RS05480	COG4651	solute:proton antiporter activity
CF59_RS05480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CF59_RS05485	COG2223	nitrite transmembrane transporter activity
CF59_RS05490	COG0737	Belongs to the 5'-nucleotidase family
CF59_RS05495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CF59_RS05500	COG3735	TraB family
CF59_RS05505	COG2217	Heavy metal translocating P-type atpase
CF59_RS05515	COG0531	amino acid
CF59_RS05545	COG0789	Transcriptional regulator
CF59_RS05570	COG1585	Membrane protein implicated in regulation of membrane protease activity
CF59_RS05575	COG0330	HflC and HflK could
CF59_RS05580	COG4619	ABC transporter
CF59_RS05585	COG0390	transport system, permease component
CF59_RS05590	COG3118	belongs to the thioredoxin family
CF59_RS05595	COG0300	oxidoreductase activity
CF59_RS05600	COG2755	lipolytic protein G-D-S-L family
CF59_RS05605	COG4181	ATPase activity
CF59_RS05610	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CF59_RS05615	COG3209	COG3209 Rhs family protein
CF59_RS05625	COG2801	Transposase and inactivated derivatives
CF59_RS05635	COG0583	DNA-binding transcription factor activity
CF59_RS05645	COG1414	Transcriptional regulator
CF59_RS05650	COG3960	tartronate-semialdehyde synthase activity
CF59_RS05655	COG3622	Belongs to the hyi family
CF59_RS05660	COG2084	Dehydrogenase
CF59_RS05665	COG1953	Uracil, thiamine, allantoin
CF59_RS05675	COG2233	PERMEase
CF59_RS05680	COG1929	Belongs to the glycerate kinase type-1 family
CF59_RS05685	COG3257	ureidoglycine aminohydrolase activity
CF59_RS05690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CF59_RS05695	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CF59_RS05700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF59_RS05705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF59_RS05715	COG0549	Belongs to the carbamate kinase family
CF59_RS05720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CF59_RS05725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CF59_RS05735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CF59_RS05745	COG1988	membrane-bound metal-dependent
CF59_RS05750	COG2501	S4 domain
CF59_RS05760	COG3539	Fimbrial protein
CF59_RS05765	COG3121	Chaperone
CF59_RS05770	COG3188	usher protein
CF59_RS05775	COG3539	Fimbrial protein
CF59_RS05780	COG3539	Fimbrial protein
CF59_RS05785	COG2197	response regulator
CF59_RS05795	COG0582	viral genome integration into host DNA
CF59_RS05880	COG2076	Multidrug Resistance protein
CF59_RS05890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF59_RS05895	COG1881	PFAM PEBP family protein
CF59_RS05900	COG2207	Transcriptional regulator
CF59_RS05945	COG3772	lysozyme
CF59_RS05965	COG5562	phage envelope protein
CF59_RS05985	COG4220	transposase activity
CF59_RS06005	COG1030	water channel activity
CF59_RS06055	COG1196	nuclear chromosome segregation
CF59_RS06095	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF59_RS06120	COG2207	Transcriptional regulator
CF59_RS06125	COG4571	Outer membrane protease
CF59_RS06135	COG2207	Transcriptional regulator
CF59_RS06145	COG4783	chaperone-mediated protein folding
CF59_RS06150	COG1215	transferase activity, transferring glycosyl groups
CF59_RS06155	COG5433	transposase activity
CF59_RS06165	COG4104	PAAR repeat-containing protein
CF59_RS06165	COG3209	COG3209 Rhs family protein
CF59_RS06195	COG4104	PAAR repeat-containing protein
CF59_RS06195	COG3209	COG3209 Rhs family protein
CF59_RS06210	COG5002	protein histidine kinase activity
CF59_RS06215	COG0745	RESPONSE REGULATOR receiver
CF59_RS06220	COG1538	Outer membrane efflux protein
CF59_RS06225	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF59_RS06230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF59_RS06235	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF59_RS06240	COG1113	amino acid transport
CF59_RS06245	COG0668	transmembrane transport
CF59_RS06255	COG2315	Protein conserved in bacteria
CF59_RS06275	COG2963	transposase activity
CF59_RS06280	COG2801	Transposase and inactivated derivatives
CF59_RS06290	COG2977	Belongs to the P-Pant transferase superfamily
CF59_RS06300	COG4771	TonB-dependent receptor
CF59_RS06305	COG2382	esterase
CF59_RS06310	COG3251	PFAM MbtH domain protein
CF59_RS06315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CF59_RS06315	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CF59_RS06320	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF59_RS06325	COG1120	ATPase activity
CF59_RS06330	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF59_RS06335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF59_RS06345	COG4592	Periplasmic binding protein
CF59_RS06350	COG1169	isochorismate synthase
CF59_RS06355	COG1021	2,3-dihydroxybenzoate-AMP ligase
CF59_RS06360	COG3433	isochorismatase activity
CF59_RS06360	COG1535	isochorismatase
CF59_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS06375	COG1966	Carbon starvation protein
CF59_RS06380	COG2879	small protein
CF59_RS06385	COG0371	Dehydrogenase
CF59_RS06390	COG0436	Aminotransferase
CF59_RS06395	COG1475	DNA binding
CF59_RS06400	COG3969	phosphoadenosine phosphosulfate
CF59_RS06405	COG0583	DNA-binding transcription factor activity
CF59_RS06410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF59_RS06415	COG0450	alkyl hydroperoxide reductase
CF59_RS06420	COG3634	alkyl hydroperoxide reductase activity
CF59_RS06425	COG0589	response to stress
CF59_RS06430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF59_RS06435	COG3719	Belongs to the RNase T2 family
CF59_RS06440	COG0471	metal ion transport
CF59_RS06455	COG3051	citrate lyase alpha subunit
CF59_RS06460	COG2301	Belongs to the HpcH HpaI aldolase family
CF59_RS06470	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CF59_RS06475	COG3290	protein histidine kinase activity
CF59_RS06480	COG4565	transcriptional regulatory protein
CF59_RS06485	COG3069	C4-dicarboxylate transmembrane transporter activity
CF59_RS06505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF59_RS06510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF59_RS06520	COG0583	DNA-binding transcription factor activity
CF59_RS06540	COG1686	Belongs to the peptidase S11 family
CF59_RS06545	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF59_RS06550	COG0772	Belongs to the SEDS family
CF59_RS06555	COG0768	penicillin binding
CF59_RS06565	COG0799	negative regulation of ribosome biogenesis
CF59_RS06570	COG0406	alpha-ribazole phosphatase activity
CF59_RS06580	COG1466	dna polymerase III delta subunit
CF59_RS06595	COG2888	peptidyl-tyrosine sulfation
CF59_RS06605	COG1126	abc transporter atp-binding protein
CF59_RS06610	COG0765	amino acid transport
CF59_RS06615	COG0765	amino acid transport
CF59_RS06620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS06625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CF59_RS06630	COG4535	Mg2 and Co2 transporter CorC
CF59_RS06640	COG1702	phosphate starvation-inducible protein PhoH
CF59_RS06650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF59_RS06690	COG0367	asparagine synthase
CF59_RS06695	COG0647	UMP catabolic process
CF59_RS06700	COG1940	carbohydrate kinase activity
CF59_RS06700	COG1846	Transcriptional regulator
CF59_RS06705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF59_RS06715	COG1263	PTS System
CF59_RS06715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS06715	COG2190	(PTS) system
CF59_RS06735	COG0735	belongs to the Fur family
CF59_RS06750	COG0716	FMN binding
CF59_RS06760	COG0596	Alpha beta hydrolase
CF59_RS06765	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CF59_RS06770	COG0033	Phosphoglucomutase
CF59_RS06775	COG0745	RESPONSE REGULATOR receiver
CF59_RS06780	COG2205	protein histidine kinase activity
CF59_RS06810	COG3209	COG3209 Rhs family protein
CF59_RS06820	COG3272	Protein of unknown function (DUF1722)
CF59_RS06825	COG0415	Belongs to the DNA photolyase family
CF59_RS06835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CF59_RS06840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CF59_RS06845	COG1984	allophanate hydrolase subunit 2
CF59_RS06860	COG3180	Ammonia monooxygenase
CF59_RS06865	COG3539	Fimbrial protein
CF59_RS06870	COG3121	Chaperone
CF59_RS06875	COG3188	usher protein
CF59_RS06880	COG3539	Fimbrial protein
CF59_RS06885	COG0372	Belongs to the citrate synthase family
CF59_RS06895	COG2009	succinate dehydrogenase
CF59_RS06900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CF59_RS06905	COG1053	succinate dehydrogenase
CF59_RS06910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CF59_RS06920	COG0567	Dehydrogenase, E1 component
CF59_RS06925	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF59_RS06935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF59_RS06945	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CF59_RS06950	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF59_RS06950	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF59_RS06955	COG1301	dicarboxylic acid transport
CF59_RS06965	COG4865	methylaspartate mutase activity
CF59_RS06975	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF59_RS06995	COG1271	oxidase subunit
CF59_RS07000	COG1294	oxidase, subunit
CF59_RS07005	COG4890	Cyd operon protein YbgT
CF59_RS07010	COG3790	cyd operon protein YbgE
CF59_RS07015	COG0824	Thioesterase
CF59_RS07020	COG0811	peptide transport
CF59_RS07025	COG0848	biopolymer transport protein
CF59_RS07030	COG3064	Membrane
CF59_RS07040	COG2885	chlorophyll binding
CF59_RS07045	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CF59_RS07060	COG3201	nicotinamide mononucleotide transporter
CF59_RS07065	COG1230	cation diffusion facilitator family transporter
CF59_RS07080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF59_RS07090	COG2017	converts alpha-aldose to the beta-anomer
CF59_RS07100	COG1085	galactose-1-phosphate uridylyltransferase
CF59_RS07105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CF59_RS07110	COG1119	ATPase activity
CF59_RS07120	COG2005	Transcriptional regulator
CF59_RS07120	COG3585	molybdate ion transport
CF59_RS07130	COG0725	ABC transporter, periplasmic molybdate-binding protein
CF59_RS07135	COG4149	molybdate abc transporter
CF59_RS07140	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CF59_RS07145	COG0561	phosphatase activity
CF59_RS07160	COG2828	Protein conserved in bacteria
CF59_RS07165	COG0471	metal ion transport
CF59_RS07170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CF59_RS07175	COG4677	pectinesterase activity
CF59_RS07180	COG1881	PFAM PEBP family protein
CF59_RS07185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CF59_RS07200	COG2226	methyltransferase
CF59_RS07205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CF59_RS07215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CF59_RS07230	COG0521	Mo-molybdopterin cofactor biosynthetic process
CF59_RS07240	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CF59_RS07245	COG0314	molybdopterin synthase activity
CF59_RS07250	COG0670	Belongs to the BI1 family
CF59_RS07255	COG0670	Belongs to the BI1 family
CF59_RS07260	COG0392	lysyltransferase activity
CF59_RS07265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF59_RS07270	COG3568	Endonuclease Exonuclease Phosphatase
CF59_RS07280	COG0842	Transport permease protein
CF59_RS07285	COG0842	Transport permease protein
CF59_RS07290	COG1131	(ABC) transporter
CF59_RS07300	COG1309	transcriptional regulator
CF59_RS07305	COG0513	Belongs to the DEAD box helicase family
CF59_RS07320	COG1199	ATP-dependent helicase activity
CF59_RS07325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CF59_RS07330	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CF59_RS07340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CF59_RS07365	COG0668	transmembrane transport
CF59_RS07375	COG1126	abc transporter atp-binding protein
CF59_RS07380	COG0765	amino acid transport
CF59_RS07385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS07400	COG5006	permease, DMT superfamily
CF59_RS07405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CF59_RS07410	COG2194	sulfuric ester hydrolase activity
CF59_RS07420	COG1321	iron dependent repressor
CF59_RS07425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CF59_RS07430	COG1376	ErfK ybiS ycfS ynhG family protein
CF59_RS07435	COG0488	(ABC) transporter
CF59_RS07445	COG2271	Major facilitator Superfamily
CF59_RS07465	COG0561	phosphatase activity
CF59_RS07470	COG1882	Formate acetyltransferase
CF59_RS07475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF59_RS07480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF59_RS07485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CF59_RS07490	COG0303	'Molybdopterin
CF59_RS07495	COG1446	asparaginase
CF59_RS07505	COG0747	negative chemotaxis
CF59_RS07520	COG2200	EAL domain
CF59_RS07525	COG2199	diguanylate cyclase activity
CF59_RS07540	COG2133	pyrroloquinoline quinone binding
CF59_RS07545	COG0625	glutathione transferase activity
CF59_RS07550	COG1686	Belongs to the peptidase S11 family
CF59_RS07555	COG1349	DNA-binding transcription factor activity
CF59_RS07560	COG0671	phosphoesterase, PA-phosphatase related
CF59_RS07565	COG2814	Major facilitator Superfamily
CF59_RS07575	COG0561	phosphatase activity
CF59_RS07580	COG0738	Major facilitator superfamily
CF59_RS07585	COG3226	Transcriptional regulator
CF59_RS07600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF59_RS07610	COG0778	Nitroreductase
CF59_RS07630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF59_RS07635	COG3842	ATPase activity
CF59_RS07640	COG1176	ABC-type spermidine putrescine transport system, permease component I
CF59_RS07645	COG1177	transmembrane transport
CF59_RS07660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS07665	COG4160	amino acid transport
CF59_RS07670	COG4215	(ABC) transporter
CF59_RS07675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS07680	COG1126	abc transporter atp-binding protein
CF59_RS07710	COG3023	N-Acetylmuramoyl-L-alanine amidase
CF59_RS07715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF59_RS07720	COG0702	epimerase
CF59_RS07725	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CF59_RS07730	COG0028	Belongs to the TPP enzyme family
CF59_RS07735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF59_RS07745	COG2431	L-lysine efflux transmembrane transporter activity
CF59_RS07750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CF59_RS07760	COG3593	DNA synthesis involved in DNA repair
CF59_RS07765	COG2990	Protein conserved in bacteria
CF59_RS07770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF59_RS07775	COG1136	(ABC) transporter
CF59_RS07775	COG0577	efflux transmembrane transporter activity
CF59_RS07780	COG1278	Cold shock
CF59_RS07790	COG0542	response to heat
CF59_RS07810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CF59_RS07815	COG4988	ABC transporter
CF59_RS07820	COG0492	ferredoxin-NADP+ reductase activity
CF59_RS07825	COG1522	sequence-specific DNA binding
CF59_RS07830	COG1178	ABC-type Fe3 transport system permease component
CF59_RS07830	COG1674	ftsk spoiiie
CF59_RS07840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CF59_RS07850	COG0243	molybdopterin cofactor binding
CF59_RS07855	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS07860	COG3302	dmso reductase anchor subunit
CF59_RS07865	COG1335	isochorismatase
CF59_RS07875	COG0531	amino acid
CF59_RS07880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF59_RS07885	COG1882	Formate acetyltransferase
CF59_RS07890	COG2116	formate transmembrane transporter activity
CF59_RS07895	COG1944	ATP diphosphatase activity
CF59_RS07900	COG2323	membrane
CF59_RS07920	COG0501	Belongs to the peptidase M48B family
CF59_RS07930	COG0539	negative regulation of cytoplasmic translation
CF59_RS07955	COG3214	Protein conserved in bacteria
CF59_RS07970	COG3173	Aminoglycoside phosphotransferase
CF59_RS07975	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CF59_RS07980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CF59_RS07990	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CF59_RS08000	COG2989	Protein conserved in bacteria
CF59_RS08005	COG3108	Peptidase M15
CF59_RS08010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CF59_RS08015	COG1448	Aminotransferase
CF59_RS08040	COG0308	aminopeptidase N
CF59_RS08045	COG2801	Transposase and inactivated derivatives
CF59_RS08065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CF59_RS08075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CF59_RS08080	COG0431	NADPH-dependent FMN reductase
CF59_RS08095	COG0633	Ferredoxin
CF59_RS08095	COG3217	Mosc domain protein beta barrel domain protein
CF59_RS08105	COG0488	(ABC) transporter
CF59_RS08110	COG2995	paraquat-inducible protein a
CF59_RS08115	COG3008	intermembrane lipid transfer
CF59_RS08115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CF59_RS08120	COG3009	Protein conserved in bacteria
CF59_RS08125	COG3130	regulation of translation
CF59_RS08135	COG1067	ATP-dependent peptidase activity
CF59_RS08160	COG3070	regulator of competence-specific genes
CF59_RS08165	COG1289	transmembrane transporter activity
CF59_RS08170	COG3304	Inner membrane component domain
CF59_RS08175	COG0210	DNA helicase
CF59_RS08195	COG1832	CoA-binding protein
CF59_RS08210	COG1254	Belongs to the acylphosphatase family
CF59_RS08215	COG2920	part of a sulfur-relay system
CF59_RS08220	COG0670	Belongs to the BI1 family
CF59_RS08230	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CF59_RS08235	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CF59_RS08240	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CF59_RS08245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF59_RS08250	COG1999	signal sequence binding
CF59_RS08255	COG1773	rubredoxin
CF59_RS08260	COG1271	oxidase subunit
CF59_RS08265	COG1294	oxidase, subunit
CF59_RS08280	COG1278	Cold shock
CF59_RS08285	COG1278	Cold shock
CF59_RS08300	COG0348	domain, Protein
CF59_RS08305	COG2198	Histidine kinase
CF59_RS08305	COG2205	protein histidine kinase activity
CF59_RS08305	COG0784	Response regulator, receiver
CF59_RS08310	COG1879	ABC-type sugar transport system periplasmic component
CF59_RS08315	COG0745	RESPONSE REGULATOR receiver
CF59_RS08320	COG3005	denitrification pathway
CF59_RS08325	COG0243	molybdopterin cofactor binding
CF59_RS08330	COG3381	protein complex oligomerization
CF59_RS08370	COG3729	General stress protein
CF59_RS08375	COG2233	PERMEase
CF59_RS08410	COG1309	transcriptional regulator
CF59_RS08415	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF59_RS08415	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF59_RS08415	COG0506	proline dehydrogenase activity
CF59_RS08425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF59_RS08450	COG1702	phosphate starvation-inducible protein PhoH
CF59_RS08470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CF59_RS08480	COG3381	protein complex oligomerization
CF59_RS08490	COG1462	curli production assembly transport component CsgG
CF59_RS08505	COG2197	response regulator
CF59_RS08535	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF59_RS08540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF59_RS08565	COG2943	transferase activity, transferring hexosyl groups
CF59_RS08570	COG5645	(Lipo)protein
CF59_RS08590	COG1560	Kdo2-lipid A biosynthetic process
CF59_RS08600	COG2353	YceI-like domain
CF59_RS08605	COG3038	cytochrome b561
CF59_RS08640	COG2999	glutathione oxidoreductase activity
CF59_RS08650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF59_RS08660	COG0673	inositol 2-dehydrogenase activity
CF59_RS08665	COG0728	peptidoglycan biosynthetic process
CF59_RS08670	COG3418	PFAM FlgN family protein
CF59_RS08675	COG2747	anti-sigma28 factor FlgM
CF59_RS08680	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CF59_RS08685	COG1815	bacterial-type flagellum-dependent cell motility
CF59_RS08690	COG1558	bacterial-type flagellum-dependent cell motility
CF59_RS08695	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CF59_RS08700	COG1749	Flagellar hook protein flgE
CF59_RS08705	COG4787	bacterial-type flagellum-dependent cell motility
CF59_RS08710	COG4786	Flagellar basal body rod
CF59_RS08725	COG3951	Flagellar rod assembly protein muramidase FlgJ
CF59_RS08725	COG1705	Flagellar rod assembly protein muramidase FlgJ
CF59_RS08730	COG1256	bacterial-type flagellum assembly
CF59_RS08735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CF59_RS08740	COG1530	ribonuclease E activity
CF59_RS08750	COG0564	pseudouridine synthase activity
CF59_RS08755	COG0424	maF-like protein
CF59_RS08760	COG1399	metal-binding, possibly nucleic acid-binding protein
CF59_RS08780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CF59_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS08795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF59_RS08800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CF59_RS08805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CF59_RS08815	COG0470	DNA polymerase III
CF59_RS08820	COG0084	hydrolase, TatD family'
CF59_RS08825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS08825	COG1263	PTS System
CF59_RS08830	COG4773	Receptor
CF59_RS08835	COG0537	adenosine 5'-monophosphoramidase activity
CF59_RS08840	COG5633	Lipoprotein
CF59_RS08845	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CF59_RS08865	COG1252	NADH dehydrogenase
CF59_RS08870	COG3134	Outer membrane lipoprotein
CF59_RS08875	COG1309	transcriptional regulator
CF59_RS08885	COG1376	ErfK ybiS ycfS ynhG family protein
CF59_RS08885	COG1388	LysM domain
CF59_RS08890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CF59_RS08895	COG4763	Acyl-transferase
CF59_RS08900	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF59_RS08910	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF59_RS08920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CF59_RS08925	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CF59_RS08935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF59_RS08940	COG1177	transmembrane transport
CF59_RS08950	COG3842	ATPase activity
CF59_RS08965	COG2850	peptidyl-arginine hydroxylation
CF59_RS08970	COG2205	protein histidine kinase activity
CF59_RS08980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CF59_RS09000	COG1187	pseudouridine synthase activity
CF59_RS09005	COG0538	isocitrate dehydrogenase activity
CF59_RS09020	COG5562	phage envelope protein
CF59_RS09025	COG0789	Transcriptional regulator
CF59_RS09030	COG2200	EAL domain
CF59_RS09055	COG2200	EAL domain
CF59_RS09100	COG2894	cell division
CF59_RS09130	COG0179	Fumarylacetoacetate (FAA) hydrolase
CF59_RS09145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CF59_RS09150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CF59_RS09155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CF59_RS09175	COG2719	SpoVR family
CF59_RS09185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CF59_RS09200	COG1619	proteins homologs of microcin C7 resistance protein MccF
CF59_RS09210	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CF59_RS09225	COG0157	Belongs to the NadC ModD family
CF59_RS09230	COG0500	methyltransferase
CF59_RS09235	COG1120	ATPase activity
CF59_RS09240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF59_RS09245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF59_RS09255	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CF59_RS09255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF59_RS09255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS09260	COG1461	Dihydroxyacetone kinase
CF59_RS09265	COG2376	Dihydroxyacetone kinase
CF59_RS09270	COG3284	Transcriptional regulator
CF59_RS09275	COG3468	outer membrane autotransporter barrel domain protein
CF59_RS09285	COG0012	GTP binding
CF59_RS09300	COG0659	secondary active sulfate transmembrane transporter activity
CF59_RS09305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CF59_RS09330	COG2890	protein-(glutamine-N5) methyltransferase activity
CF59_RS09335	COG3094	Invasion gene expression up-regulator, SirB
CF59_RS09340	COG2912	Transglutaminase-like superfamily
CF59_RS09360	COG0387	Pfam Sodium calcium exchanger
CF59_RS09365	COG4572	Cation transport regulator
CF59_RS09370	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CF59_RS09375	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CF59_RS09380	COG4932	domain protein
CF59_RS09385	COG2197	response regulator
CF59_RS09390	COG3850	Histidine kinase
CF59_RS09400	COG2223	nitrite transmembrane transporter activity
CF59_RS09405	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CF59_RS09410	COG1140	nitrate reductase beta subunit
CF59_RS09415	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CF59_RS09420	COG2181	nitrate reductase activity
CF59_RS09435	COG0788	formyltetrahydrofolate deformylase activity
CF59_RS09445	COG1752	Esterase of the alpha-beta hydrolase superfamily
CF59_RS09450	COG0745	RESPONSE REGULATOR receiver
CF59_RS09455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CF59_RS09465	COG1435	thymidine kinase activity
CF59_RS09470	COG1454	alcohol dehydrogenase
CF59_RS09470	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS09475	COG2095	MarC family integral membrane protein
CF59_RS09480	COG4166	transmembrane transport
CF59_RS09485	COG0601	transmembrane transport
CF59_RS09490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF59_RS09495	COG0444	Belongs to the ABC transporter superfamily
CF59_RS09500	COG4608	Belongs to the ABC transporter superfamily
CF59_RS09525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CF59_RS09530	COG2350	Protein conserved in bacteria
CF59_RS09535	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CF59_RS09540	COG1607	acyl-coa hydrolase
CF59_RS09555	COG3047	cAMP biosynthetic process
CF59_RS09560	COG3685	Protein conserved in bacteria
CF59_RS09570	COG3729	General stress protein
CF59_RS09575	COG0159	tryptophan synthase activity
CF59_RS09585	COG0134	indole-3-glycerol-phosphate synthase activity
CF59_RS09585	COG0135	phosphoribosylanthranilate isomerase activity
CF59_RS09590	COG0512	Glutamine amidotransferase of anthranilate synthase
CF59_RS09590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CF59_RS09595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CF59_RS09600	COG0613	PHP domain protein
CF59_RS09605	COG0009	L-threonylcarbamoyladenylate synthase
CF59_RS09615	COG1187	pseudouridine synthase activity
CF59_RS09630	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CF59_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS09645	COG0616	signal peptide processing
CF59_RS09660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CF59_RS09665	COG0583	DNA-binding transcription factor activity
CF59_RS09690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CF59_RS09700	COG0671	phosphoesterase, PA-phosphatase related
CF59_RS09705	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CF59_RS09710	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CF59_RS09720	COG0023	Translation Initiation Factor
CF59_RS09730	COG1349	DNA-binding transcription factor activity
CF59_RS09740	COG5001	Diguanylate cyclase
CF59_RS09755	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF59_RS09755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF59_RS09760	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CF59_RS09770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF59_RS09775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF59_RS09785	COG2814	Major facilitator Superfamily
CF59_RS09790	COG4172	Belongs to the ABC transporter superfamily
CF59_RS09795	COG4172	Belongs to the ABC transporter superfamily
CF59_RS09800	COG4171	peptide transport system, permease
CF59_RS09805	COG4168	peptide transport system, permease
CF59_RS09810	COG4166	transmembrane transport
CF59_RS09825	COG0531	amino acid
CF59_RS09830	COG0174	glutamine synthetase
CF59_RS09835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CF59_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS09845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CF59_RS09850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CF59_RS09855	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CF59_RS09860	COG1842	Phage shock protein A
CF59_RS09870	COG1983	PspC domain protein
CF59_RS09880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF59_RS09885	COG3106	COG3106 Predicted ATPase
CF59_RS09895	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CF59_RS09900	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CF59_RS09905	COG4948	Mandelate Racemase Muconate Lactonizing
CF59_RS09910	COG2866	Carboxypeptidase
CF59_RS09915	COG0702	epimerase
CF59_RS09920	COG1073	alpha beta
CF59_RS09925	COG0583	DNA-binding transcription factor activity
CF59_RS09935	COG4166	transmembrane transport
CF59_RS09940	COG0668	transmembrane transport
CF59_RS09945	COG3182	Iron-regulated membrane protein
CF59_RS09950	COG0589	response to stress
CF59_RS09955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF59_RS09960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CF59_RS09965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CF59_RS09975	COG1473	amidohydrolase
CF59_RS09980	COG1473	amidohydrolase
CF59_RS09985	COG0583	DNA-binding transcription factor activity
CF59_RS09995	COG2207	Transcriptional regulator
CF59_RS10010	COG2840	Smr protein MutS2
CF59_RS10015	COG3706	GGDEF domain
CF59_RS10030	COG0513	Belongs to the DEAD box helicase family
CF59_RS10040	COG0582	viral genome integration into host DNA
CF59_RS10065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF59_RS10095	COG4197	protein conserved in bacteria, prophage-related
CF59_RS10105	COG3756	Protein conserved in bacteria
CF59_RS10110	COG1484	DNA-dependent DNA replication
CF59_RS10115	COG1846	Transcriptional regulator
CF59_RS10165	COG3064	Membrane
CF59_RS10180	COG3772	lysozyme
CF59_RS10190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CF59_RS10195	COG1475	DNA binding
CF59_RS10275	COG1196	nuclear chromosome segregation
CF59_RS10310	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF59_RS10345	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF59_RS10355	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF59_RS10360	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF59_RS10465	COG2207	Transcriptional regulator
CF59_RS10485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CF59_RS10670	COG0305	Participates in initiation and elongation during chromosome replication
CF59_RS10705	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CF59_RS10840	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF59_RS10860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF59_RS10870	COG0589	response to stress
CF59_RS10875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF59_RS10880	COG0674	pyruvate-flavodoxin oxidoreductase activity
CF59_RS10880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF59_RS10880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CF59_RS10880	COG1013	pyruvate-flavodoxin oxidoreductase activity
CF59_RS10885	COG3042	response to heat
CF59_RS10890	COG3187	Heat shock protein
CF59_RS10895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CF59_RS10900	COG2911	Protein conserved in bacteria
CF59_RS10910	COG3784	Protein of unknown function (DUF1318)
CF59_RS10915	COG2207	Transcriptional regulator
CF59_RS10920	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS10925	COG3733	amine oxidase
CF59_RS10930	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS10930	COG2030	dehydratase
CF59_RS10935	COG3396	Phenylacetate-CoA oxygenase
CF59_RS10940	COG3460	Phenylacetate-CoA oxygenase
CF59_RS10945	COG3396	Phenylacetate-CoA oxygenase
CF59_RS10950	COG2151	metal-sulfur cluster biosynthetic enzyme
CF59_RS10955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF59_RS10960	COG1024	Enoyl-CoA hydratase
CF59_RS10965	COG1024	Enoyl-CoA hydratase
CF59_RS10970	COG1250	3-hydroxyacyl-CoA dehydrogenase
CF59_RS10975	COG2050	protein possibly involved in aromatic compounds catabolism
CF59_RS10980	COG0183	Belongs to the thiolase family
CF59_RS10985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CF59_RS10990	COG3327	negative regulation of DNA-templated transcription, initiation
CF59_RS10995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF59_RS11005	COG0667	Aldo Keto reductase
CF59_RS11015	COG1643	Atp-dependent helicase
CF59_RS11020	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CF59_RS11030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CF59_RS11035	COG3038	cytochrome b561
CF59_RS11050	COG2801	Transposase and inactivated derivatives
CF59_RS11055	COG2963	transposase activity
CF59_RS11060	COG0840	transmembrane signaling receptor activity
CF59_RS11065	COG0583	DNA-binding transcription factor activity
CF59_RS11070	COG5383	Protein conserved in bacteria
CF59_RS11085	COG2841	Protein conserved in bacteria
CF59_RS11090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF59_RS11095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF59_RS11100	COG1275	C4-dicarboxylate transporter malic acid transport protein
CF59_RS11105	COG0500	methyltransferase
CF59_RS11115	COG3135	benzoate transporter
CF59_RS11120	COG1396	sequence-specific DNA binding
CF59_RS11125	COG0826	peptidase U32
CF59_RS11135	COG1724	mRNA binding
CF59_RS11140	COG1598	PFAM Uncharacterised protein family UPF0150
CF59_RS11145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF59_RS11150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF59_RS11155	COG3842	ATPase activity
CF59_RS11160	COG1176	ABC-type spermidine putrescine transport system, permease component I
CF59_RS11165	COG1177	transmembrane transport
CF59_RS11190	COG3238	Protein conserved in bacteria
CF59_RS11195	COG1247	-acetyltransferase
CF59_RS11200	COG2130	NADP-dependent
CF59_RS11205	COG1802	Transcriptional regulator
CF59_RS11210	COG4772	TonB-dependent receptor
CF59_RS11215	COG3391	amine dehydrogenase activity
CF59_RS11220	COG1113	amino acid transport
CF59_RS11240	COG3209	COG3209 Rhs family protein
CF59_RS11250	COG5433	transposase activity
CF59_RS11255	COG4251	negative regulation of phosphorylation
CF59_RS11255	COG5001	Diguanylate cyclase
CF59_RS11255	COG2203	Gaf domain
CF59_RS11255	COG3706	GGDEF domain
CF59_RS11260	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CF59_RS11270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CF59_RS11275	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CF59_RS11280	COG0384	phenazine biosynthesis protein PhzF
CF59_RS11285	COG2181	nitrate reductase activity
CF59_RS11290	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CF59_RS11295	COG1140	nitrate reductase beta subunit
CF59_RS11300	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CF59_RS11305	COG2223	nitrite transmembrane transporter activity
CF59_RS11310	COG4886	Leucine-rich repeat (LRR) protein
CF59_RS11315	COG4886	Leucine-rich repeat (LRR) protein
CF59_RS11325	COG0697	spore germination
CF59_RS11330	COG3383	formate dehydrogenase (NAD+) activity
CF59_RS11330	COG0243	molybdopterin cofactor binding
CF59_RS11335	COG0243	molybdopterin cofactor binding
CF59_RS11335	COG3383	formate dehydrogenase (NAD+) activity
CF59_RS11340	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS11345	COG2864	formate dehydrogenase
CF59_RS11360	COG3093	addiction module antidote protein HigA
CF59_RS11365	COG1064	alcohol dehydrogenase
CF59_RS11385	COG1764	response to oxidative stress
CF59_RS11390	COG4608	Belongs to the ABC transporter superfamily
CF59_RS11395	COG0444	Belongs to the ABC transporter superfamily
CF59_RS11400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF59_RS11405	COG0601	transmembrane transport
CF59_RS11410	COG0747	negative chemotaxis
CF59_RS11415	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CF59_RS11420	COG2202	Pas domain
CF59_RS11420	COG2200	EAL domain
CF59_RS11420	COG2199	diguanylate cyclase activity
CF59_RS11430	COG1649	PFAM Uncharacterised BCR, COG1649
CF59_RS11435	COG0531	amino acid
CF59_RS11440	COG0076	glutamate decarboxylase activity
CF59_RS11450	COG0612	Peptidase, M16
CF59_RS11455	COG4771	TonB-dependent receptor
CF59_RS11460	COG4178	(ABC) transporter
CF59_RS11465	COG0641	radical SAM
CF59_RS11470	COG3119	arylsulfatase activity
CF59_RS11485	COG0243	molybdopterin cofactor binding
CF59_RS11490	COG3539	Fimbrial protein
CF59_RS11495	COG3539	Fimbrial protein
CF59_RS11500	COG3539	Fimbrial protein
CF59_RS11505	COG3188	usher protein
CF59_RS11515	COG3539	Fimbrial protein
CF59_RS11520	COG4977	sequence-specific DNA binding
CF59_RS11535	COG0667	Aldo Keto reductase
CF59_RS11555	COG3550	peptidyl-serine autophosphorylation
CF59_RS11560	COG1396	sequence-specific DNA binding
CF59_RS11565	COG3210	domain, Protein
CF59_RS11565	COG2911	Protein conserved in bacteria
CF59_RS11615	COG3781	membrane
CF59_RS11630	COG2199	diguanylate cyclase activity
CF59_RS11640	COG2066	Belongs to the glutaminase family
CF59_RS11645	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS11650	COG0583	DNA-binding transcription factor activity
CF59_RS11670	COG1846	Transcriptional regulator
CF59_RS11675	COG4977	sequence-specific DNA binding
CF59_RS11685	COG2723	6-phospho-beta-galactosidase activity
CF59_RS11695	COG1447	Phosphotransferase system cellobiose-specific component IIA
CF59_RS11700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF59_RS11710	COG2188	Transcriptional regulator
CF59_RS11715	COG0697	spore germination
CF59_RS11720	COG2814	Major facilitator Superfamily
CF59_RS11730	COG3706	GGDEF domain
CF59_RS11735	COG3111	PFAM Bacterial OB fold (BOF) protein
CF59_RS11745	COG0339	signal peptide processing
CF59_RS11750	COG4221	oxidoreductase activity
CF59_RS11755	COG1802	Transcriptional regulator
CF59_RS11765	COG0246	Mannitol dehydrogenase
CF59_RS11770	COG0477	Major facilitator Superfamily
CF59_RS11775	COG1063	alcohol dehydrogenase
CF59_RS11780	COG4948	Mandelate Racemase Muconate Lactonizing
CF59_RS11795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF59_RS11810	COG0243	molybdopterin cofactor binding
CF59_RS11815	COG0243	molybdopterin cofactor binding
CF59_RS11820	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS11825	COG3302	dmso reductase anchor subunit
CF59_RS11830	COG3381	protein complex oligomerization
CF59_RS11840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CF59_RS11845	COG1940	carbohydrate kinase activity
CF59_RS11850	COG0583	DNA-binding transcription factor activity
CF59_RS11855	COG2814	Major facilitator Superfamily
CF59_RS11870	COG3591	Belongs to the peptidase S1B family
CF59_RS11885	COG0628	permease
CF59_RS11890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CF59_RS11895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CF59_RS11905	COG0531	amino acid
CF59_RS11915	COG3136	membrane protein required for alginate biosynthesis
CF59_RS11920	COG0745	RESPONSE REGULATOR receiver
CF59_RS11925	COG2205	protein histidine kinase activity
CF59_RS11935	COG0114	fumarate hydratase activity
CF59_RS11940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF59_RS11940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF59_RS11945	COG1482	cell wall glycoprotein biosynthetic process
CF59_RS11950	COG5339	Protein conserved in bacteria
CF59_RS11965	COG3250	beta-galactosidase activity
CF59_RS11970	COG1309	transcriptional regulator
CF59_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS11980	COG1609	Transcriptional regulator
CF59_RS11985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS11985	COG1263	PTS System
CF59_RS11990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CF59_RS12000	COG0673	inositol 2-dehydrogenase activity
CF59_RS12035	COG4658	electron transport chain
CF59_RS12040	COG4659	FMN binding
CF59_RS12050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CF59_RS12060	COG3104	oligopeptide transport
CF59_RS12065	COG0625	glutathione transferase activity
CF59_RS12070	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CF59_RS12085	COG3895	Periplasmic Protein
CF59_RS12095	COG3133	Outer membrane lipoprotein
CF59_RS12110	COG1566	PFAM secretion protein HlyD family protein
CF59_RS12115	COG1289	transmembrane transporter activity
CF59_RS12120	COG2032	superoxide dismutase activity
CF59_RS12125	COG4989	oxidoreductase activity
CF59_RS12130	COG3313	Fe-S protein
CF59_RS12135	COG1309	transcriptional regulator
CF59_RS12140	COG1902	pentaerythritol trinitrate reductase activity
CF59_RS12145	COG0346	lactoylglutathione lyase activity
CF59_RS12155	COG1201	RNA secondary structure unwinding
CF59_RS12160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CF59_RS12165	COG0791	NLP P60 protein
CF59_RS12170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CF59_RS12175	COG2814	Major facilitator Superfamily
CF59_RS12190	COG0583	DNA-binding transcription factor activity
CF59_RS12195	COG2814	Major facilitator Superfamily
CF59_RS12200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CF59_RS12205	COG0307	riboflavin synthase, alpha
CF59_RS12215	COG3468	outer membrane autotransporter barrel domain protein
CF59_RS12235	COG4529	Protein conserved in bacteria
CF59_RS12245	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CF59_RS12250	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS12260	COG2414	aldehyde ferredoxin oxidoreductase
CF59_RS12265	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS12275	COG0469	pyruvate kinase activity
CF59_RS12280	COG4238	major outer membrane lipoprotein
CF59_RS12285	COG1376	ErfK ybiS ycfS ynhG family protein
CF59_RS12300	COG0719	Fe-S assembly protein
CF59_RS12305	COG0396	ATPase activity
CF59_RS12310	COG0719	Fe-S assembly protein
CF59_RS12315	COG0316	Belongs to the HesB IscA family
CF59_RS12325	COG2050	protein possibly involved in aromatic compounds catabolism
CF59_RS12330	COG0247	lactate metabolic process
CF59_RS12330	COG0277	FAD linked oxidase domain protein
CF59_RS12335	COG0628	permease
CF59_RS12345	COG0738	Major facilitator superfamily
CF59_RS12350	COG2271	Major facilitator Superfamily
CF59_RS12365	COG4670	ketone body catabolic process
CF59_RS12370	COG1960	acyl-CoA dehydrogenase activity
CF59_RS12375	COG1917	Cupin 2, conserved barrel domain protein
CF59_RS12375	COG2207	Transcriptional regulator
CF59_RS12385	COG2086	electron transfer activity
CF59_RS12390	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CF59_RS12395	COG0644	oxidoreductase
CF59_RS12400	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF59_RS12405	COG0318	PFAM AMP-dependent synthetase and ligase
CF59_RS12410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF59_RS12410	COG0574	Belongs to the PEP-utilizing enzyme family
CF59_RS12425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF59_RS12430	COG4256	Hemin uptake protein
CF59_RS12440	COG2200	EAL domain
CF59_RS12445	COG0791	NLP P60 protein
CF59_RS12455	COG0386	Belongs to the glutathione peroxidase family
CF59_RS12510	COG3137	Salt-induced outer membrane protein
CF59_RS12515	COG1105	Belongs to the carbohydrate kinase PfkB family
CF59_RS12525	COG3001	Fructosamine kinase
CF59_RS12535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF59_RS12540	COG1988	membrane-bound metal-dependent
CF59_RS12545	COG1823	symporter activity
CF59_RS12560	COG0753	catalase activity
CF59_RS12570	COG1486	melibiose metabolic process
CF59_RS12575	COG1917	Cupin 2, conserved barrel domain protein
CF59_RS12575	COG2169	Transcriptional regulator
CF59_RS12580	COG1447	Phosphotransferase system cellobiose-specific component IIA
CF59_RS12585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF59_RS12590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF59_RS12595	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF59_RS12610	COG0322	excinuclease ABC activity
CF59_RS12620	COG3678	ATP-independent chaperone mediated protein folding
CF59_RS12650	COG0708	Exodeoxyribonuclease III
CF59_RS12655	COG0398	Pfam SNARE associated Golgi protein
CF59_RS12665	COG0398	Pfam SNARE associated Golgi protein
CF59_RS12670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF59_RS12675	COG4134	Bacterial extracellular solute-binding protein
CF59_RS12680	COG4135	transport system, permease component
CF59_RS12685	COG4136	ATPase activity
CF59_RS12690	COG2897	thiosulfate sulfurtransferase activity
CF59_RS12695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CF59_RS12700	COG0494	nUDIX hydrolase
CF59_RS12710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CF59_RS12720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CF59_RS12725	COG0709	Synthesizes selenophosphate from selenide and ATP
CF59_RS12735	COG0778	Nitroreductase
CF59_RS12745	COG0616	signal peptide processing
CF59_RS12750	COG0252	asparaginase activity
CF59_RS12755	COG1335	isochorismatase
CF59_RS12760	COG2814	Major facilitator Superfamily
CF59_RS12765	COG1349	DNA-binding transcription factor activity
CF59_RS12770	COG0667	Aldo Keto reductase
CF59_RS12775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF59_RS12780	COG0191	fructose-bisphosphate aldolase activity
CF59_RS12785	COG1063	alcohol dehydrogenase
CF59_RS12790	COG2271	Major facilitator Superfamily
CF59_RS12795	COG1063	alcohol dehydrogenase
CF59_RS12800	COG3139	Protein of unknown function (DUF1315)
CF59_RS12810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CF59_RS12815	COG0676	glucose-6-phosphate 1-epimerase activity
CF59_RS12820	COG0656	L-ascorbic acid biosynthetic process
CF59_RS12825	COG3713	MltA-interacting MipA family protein
CF59_RS12830	COG2766	serine protein kinase
CF59_RS12840	COG2199	diguanylate cyclase activity
CF59_RS12845	COG2199	diguanylate cyclase activity
CF59_RS12850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CF59_RS12865	COG2207	Transcriptional regulator
CF59_RS12870	COG2807	transmembrane transport
CF59_RS12875	COG3189	MarR family transcriptional regulator
CF59_RS12880	COG3042	response to heat
CF59_RS12885	COG2199	diguanylate cyclase activity
CF59_RS12885	COG2203	Gaf domain
CF59_RS12895	COG2261	transglycosylase associated protein
CF59_RS12905	COG3615	Tellurite resistance protein tehB
CF59_RS12920	COG0473	3-isopropylmalate dehydrogenase activity
CF59_RS12925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CF59_RS12930	COG4638	Rieske (2fe-2S)
CF59_RS12935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF59_RS12940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CF59_RS12945	COG0318	PFAM AMP-dependent synthetase and ligase
CF59_RS12950	COG3065	identical protein binding
CF59_RS12955	COG1214	PFAM Peptidase M22, glycoprotease
CF59_RS12960	COG1199	ATP-dependent helicase activity
CF59_RS12965	COG0251	oxidation-reduction process
CF59_RS12985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CF59_RS12990	COG0494	nUDIX hydrolase
CF59_RS12995	COG1760	l-serine dehydratase
CF59_RS13000	COG2200	EAL domain
CF59_RS13005	COG1253	flavin adenine dinucleotide binding
CF59_RS13015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS13015	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS13020	COG3715	PTS system
CF59_RS13025	COG3716	PTS system mannose fructose sorbose family IID component
CF59_RS13045	COG2226	methyltransferase
CF59_RS13080	COG1414	Transcriptional regulator
CF59_RS13085	COG2814	Major facilitator Superfamily
CF59_RS13095	COG0793	Belongs to the peptidase S41A family
CF59_RS13105	COG1956	GAF domain-containing protein
CF59_RS13110	COG2995	paraquat-inducible protein a
CF59_RS13115	COG3008	intermembrane lipid transfer
CF59_RS13135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CF59_RS13150	COG1276	copper resistance
CF59_RS13155	COG2372	response to copper ion
CF59_RS13165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF59_RS13170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF59_RS13175	COG1770	oligopeptidase
CF59_RS13190	COG2979	Protein of unknown function (DUF533)
CF59_RS13205	COG3141	response to X-ray
CF59_RS13215	COG0800	Aldolase
CF59_RS13220	COG0129	dihydroxy-acid dehydratase activity
CF59_RS13225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CF59_RS13235	COG1737	Transcriptional regulator
CF59_RS13240	COG0469	pyruvate kinase activity
CF59_RS13250	COG1560	Kdo2-lipid A biosynthetic process
CF59_RS13255	COG0739	heme binding
CF59_RS13260	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CF59_RS13270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CF59_RS13295	COG0217	transcriptional regulatory protein
CF59_RS13300	COG0494	nUDIX hydrolase
CF59_RS13310	COG1335	isochorismatase
CF59_RS13315	COG1801	Protein of unknown function DUF72
CF59_RS13320	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CF59_RS13335	COG0243	molybdopterin cofactor binding
CF59_RS13340	COG3005	denitrification pathway
CF59_RS13350	COG3102	Protein conserved in bacteria
CF59_RS13365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CF59_RS13385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CF59_RS13390	COG0840	transmembrane signaling receptor activity
CF59_RS13395	COG0840	transmembrane signaling receptor activity
CF59_RS13400	COG0835	chemotaxis
CF59_RS13405	COG0643	Histidine kinase
CF59_RS13405	COG2198	Histidine kinase
CF59_RS13410	COG1360	Flagellar Motor Protein
CF59_RS13415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CF59_RS13430	COG0589	response to stress
CF59_RS13440	COG1877	trehalose-phosphatase activity
CF59_RS13445	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF59_RS13450	COG1129	ABC transporter
CF59_RS13455	COG1879	ABC-type sugar transport system periplasmic component
CF59_RS13460	COG1528	Iron-storage protein
CF59_RS13480	COG1528	Iron-storage protein
CF59_RS13490	COG0814	amino acid
CF59_RS13495	COG3012	SEC-C Motif Domain Protein
CF59_RS13495	COG3318	Belongs to the UPF0149 family
CF59_RS13525	COG2197	response regulator
CF59_RS13540	COG2197	response regulator
CF59_RS13545	COG1126	abc transporter atp-binding protein
CF59_RS13550	COG0765	amino acid transport
CF59_RS13560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS13570	COG1191	sigma factor activity
CF59_RS13580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CF59_RS13585	COG1516	flagellar protein fliS
CF59_RS13595	COG0366	Alpha amylase catalytic
CF59_RS13605	COG2391	methyltransferase activity
CF59_RS13610	COG0425	Belongs to the sulfur carrier protein TusA family
CF59_RS13615	COG2135	peptidase activity
CF59_RS13620	COG0454	-acetyltransferase
CF59_RS13645	COG1766	The M ring may be actively involved in energy transduction
CF59_RS13650	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF59_RS13655	COG1317	bacterial-type flagellum organization
CF59_RS13660	COG1157	protein secretion by the type III secretion system
CF59_RS13665	COG2882	bacterial-type flagellum organization
CF59_RS13670	COG3144	bacterial-type flagellum assembly
CF59_RS13675	COG1580	Controls the rotational direction of flagella during chemotaxis
CF59_RS13685	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF59_RS13690	COG3190	flagellar
CF59_RS13695	COG1338	Plays a role in the flagellum-specific transport system
CF59_RS13700	COG1987	bacterial-type flagellum assembly
CF59_RS13705	COG1684	flagellar biosynthetic protein fliR
CF59_RS13710	COG2197	response regulator
CF59_RS13735	COG5475	Uncharacterized small protein (DUF2158)
CF59_RS13740	COG2354	Protein conserved in bacteria
CF59_RS13745	COG0697	spore germination
CF59_RS13750	COG3727	T/G mismatch-specific endonuclease activity
CF59_RS13755	COG0270	DNA (cytosine-5-)-methyltransferase activity
CF59_RS13760	COG1418	mRNA catabolic process
CF59_RS13770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF59_RS13785	COG2205	protein histidine kinase activity
CF59_RS13790	COG0745	RESPONSE REGULATOR receiver
CF59_RS13795	COG2351	hydroxyisourate hydrolase activity
CF59_RS13810	COG3443	Belongs to the bacterial solute-binding protein 9 family
CF59_RS13835	COG1388	LysM domain
CF59_RS13835	COG2373	Large extracellular alpha-helical protein
CF59_RS13835	COG4932	domain protein
CF59_RS13845	COG0477	Major facilitator Superfamily
CF59_RS13850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CF59_RS13855	COG0217	transcriptional regulatory protein
CF59_RS13865	COG3209	COG3209 Rhs family protein
CF59_RS13875	COG3423	Transcriptional regulator
CF59_RS13900	COG0534	Mate efflux family protein
CF59_RS13910	COG0583	DNA-binding transcription factor activity
CF59_RS13915	COG0583	DNA-binding transcription factor activity
CF59_RS13925	COG1376	ErfK ybiS ycfS ynhG family protein
CF59_RS13940	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CF59_RS13960	COG1289	transmembrane transporter activity
CF59_RS13970	COG1686	Belongs to the peptidase S11 family
CF59_RS13975	COG2925	Exonuclease
CF59_RS13980	COG0531	amino acid
CF59_RS13985	COG0583	DNA-binding transcription factor activity
CF59_RS13990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF59_RS13995	COG4115	mRNA cleavage
CF59_RS14000	COG2161	toxin-antitoxin pair type II binding
CF59_RS14010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CF59_RS14020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CF59_RS14020	COG0131	Imidazoleglycerol-phosphate dehydratase
CF59_RS14025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CF59_RS14050	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF59_RS14060	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CF59_RS14085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF59_RS14090	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CF59_RS14110	COG2244	polysaccharide biosynthetic process
CF59_RS14120	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CF59_RS14125	COG1091	dTDP-4-dehydrorhamnose reductase activity
CF59_RS14130	COG1088	dTDP-glucose 4,6-dehydratase activity
CF59_RS14135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CF59_RS14145	COG0438	transferase activity, transferring glycosyl groups
CF59_RS14150	COG2327	Polysaccharide pyruvyl transferase
CF59_RS14155	COG2244	polysaccharide biosynthetic process
CF59_RS14160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CF59_RS14165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CF59_RS14170	COG0662	Cupin 2, conserved barrel domain protein
CF59_RS14170	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CF59_RS14175	COG0297	glycogen (starch) synthase activity
CF59_RS14180	COG1051	belongs to the nudix hydrolase family
CF59_RS14185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF59_RS14190	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CF59_RS14195	COG0110	maltose O-acetyltransferase activity
CF59_RS14200	COG1216	Glycosyl transferase, family 2
CF59_RS14210	COG0438	transferase activity, transferring glycosyl groups
CF59_RS14215	COG1045	serine acetyltransferase
CF59_RS14220	COG0463	Glycosyl transferase, family 2
CF59_RS14225	COG0489	protein tyrosine kinase activity
CF59_RS14225	COG3206	protein involved in exopolysaccharide biosynthesis
CF59_RS14230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CF59_RS14235	COG1596	polysaccharide export
CF59_RS14240	COG1253	flavin adenine dinucleotide binding
CF59_RS14245	COG2982	Protein involved in outer membrane biogenesis
CF59_RS14255	COG0572	uridine kinase
CF59_RS14260	COG3447	MASE1 domain protein
CF59_RS14260	COG5002	protein histidine kinase activity
CF59_RS14260	COG5001	Diguanylate cyclase
CF59_RS14265	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CF59_RS14270	COG0443	Heat shock 70 kDa protein
CF59_RS14275	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
CF59_RS14280	COG0631	protein serine/threonine phosphatase activity
CF59_RS14285	COG4245	von Willebrand factor, type A
CF59_RS14310	COG2205	protein histidine kinase activity
CF59_RS14315	COG0745	RESPONSE REGULATOR receiver
CF59_RS14325	COG0826	peptidase U32
CF59_RS14370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF59_RS14385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF59_RS14495	COG4695	Portal protein
CF59_RS14550	COG4974	Belongs to the 'phage' integrase family
CF59_RS14575	COG1063	alcohol dehydrogenase
CF59_RS14580	COG3775	system Galactitol-specific IIC component
CF59_RS14585	COG3414	Phosphotransferase system galactitol-specific IIB component
CF59_RS14590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS14595	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
CF59_RS14605	COG1830	Aldolase
CF59_RS14610	COG2211	Major facilitator Superfamily
CF59_RS14615	COG1397	ADP-ribosylglycohydrolase
CF59_RS14620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF59_RS14625	COG2188	Transcriptional regulator
CF59_RS14630	COG3757	hydrolase, family 25
CF59_RS14635	COG0351	phosphomethylpyrimidine kinase
CF59_RS14655	COG5455	response to cobalt ion
CF59_RS14660	COG3539	Fimbrial protein
CF59_RS14665	COG3188	usher protein
CF59_RS14670	COG3121	Chaperone
CF59_RS14675	COG3539	Fimbrial protein
CF59_RS14690	COG0489	protein tyrosine kinase activity
CF59_RS14700	COG3831	ATPase activity
CF59_RS14705	COG3831	ATPase activity
CF59_RS14720	COG0714	Associated with various cellular activities
CF59_RS14725	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CF59_RS14730	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CF59_RS14735	COG4715	Zinc finger, swim domain protein
CF59_RS14740	COG4808	Protein conserved in bacteria
CF59_RS14745	COG4807	Protein conserved in bacteria
CF59_RS14750	COG3279	Response regulator of the LytR AlgR family
CF59_RS14755	COG3275	phosphorelay sensor kinase activity
CF59_RS14760	COG0789	Transcriptional regulator
CF59_RS14770	COG1174	glycine betaine transport
CF59_RS14775	COG1125	glycine betaine transport
CF59_RS14780	COG1174	glycine betaine transport
CF59_RS14785	COG1732	Glycine betaine
CF59_RS14790	COG1472	Belongs to the glycosyl hydrolase 3 family
CF59_RS14795	COG0277	FAD linked oxidase domain protein
CF59_RS14800	COG1686	Belongs to the peptidase S11 family
CF59_RS14810	COG0586	Pfam SNARE associated Golgi protein
CF59_RS14815	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS14830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF59_RS14835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF59_RS14840	COG0625	glutathione transferase activity
CF59_RS14855	COG2271	Major facilitator Superfamily
CF59_RS14870	COG1346	cytolysis
CF59_RS14880	COG2949	membrane
CF59_RS14890	COG0493	'glutamate synthase
CF59_RS14895	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CF59_RS14895	COG0167	dihydroorotate dehydrogenase activity
CF59_RS14900	COG4211	Belongs to the binding-protein-dependent transport system permease family
CF59_RS14905	COG1129	ABC transporter
CF59_RS14910	COG1879	ABC-type sugar transport system periplasmic component
CF59_RS14915	COG1609	Transcriptional regulator
CF59_RS14925	COG2311	Membrane
CF59_RS14945	COG4771	TonB-dependent receptor
CF59_RS14955	COG0833	amino acid
CF59_RS14960	COG0583	DNA-binding transcription factor activity
CF59_RS14965	COG2855	membrane
CF59_RS14975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF59_RS14975	COG1522	sequence-specific DNA binding
CF59_RS14980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF59_RS14990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF59_RS14995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF59_RS15000	COG2313	pseudouridylate synthase activity
CF59_RS15005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF59_RS15010	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CF59_RS15010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS15010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS15015	COG1105	Belongs to the carbohydrate kinase PfkB family
CF59_RS15020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS15020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS15025	COG2814	Major facilitator Superfamily
CF59_RS15040	COG0246	Mannitol dehydrogenase
CF59_RS15045	COG0523	cobalamin synthesis protein
CF59_RS15050	COG0671	phosphoesterase, PA-phosphatase related
CF59_RS15055	COG0791	NLP P60 protein
CF59_RS15060	COG2200	EAL domain
CF59_RS15065	COG4166	transmembrane transport
CF59_RS15070	COG4174	ABC transporter (Permease)
CF59_RS15075	COG4239	(ABC) transporter, permease
CF59_RS15080	COG4172	Belongs to the ABC transporter superfamily
CF59_RS15090	COG2814	Major facilitator Superfamily
CF59_RS15095	COG1187	pseudouridine synthase activity
CF59_RS15100	COG1061	Type III restriction enzyme res subunit
CF59_RS15120	COG3083	sulfuric ester hydrolase activity
CF59_RS15130	COG3468	outer membrane autotransporter barrel domain protein
CF59_RS15140	COG2197	response regulator
CF59_RS15145	COG3088	subunit of a heme lyase
CF59_RS15145	COG4235	cytochrome complex assembly
CF59_RS15150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CF59_RS15155	COG1138	Cytochrome C-type biogenesis protein
CF59_RS15165	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF59_RS15170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF59_RS15175	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF59_RS15180	COG4133	protoheme IX ABC transporter activity
CF59_RS15185	COG3005	denitrification pathway
CF59_RS15190	COG3043	anaerobic respiration
CF59_RS15195	COG0348	domain, Protein
CF59_RS15200	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS15210	COG3062	negative regulation of establishment of protein localization
CF59_RS15215	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS15215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS15235	COG4615	Cyclic peptide transporter
CF59_RS15240	COG3145	DNA-N1-methyladenine dioxygenase activity
CF59_RS15245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CF59_RS15245	COG2169	Transcriptional regulator
CF59_RS15250	COG1477	protein flavinylation
CF59_RS15255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF59_RS15265	COG2198	Histidine kinase
CF59_RS15265	COG0642	Histidine kinase
CF59_RS15270	COG2197	response regulator
CF59_RS15275	COG0784	Response regulator, receiver
CF59_RS15275	COG2205	protein histidine kinase activity
CF59_RS15280	COG3852	Histidine kinase
CF59_RS15295	COG0784	Response regulator, receiver
CF59_RS15295	COG2205	protein histidine kinase activity
CF59_RS15310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CF59_RS15315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CF59_RS15320	COG2031	fatty acid transporter
CF59_RS15330	COG4676	Protein conserved in bacteria
CF59_RS15340	COG4676	Protein conserved in bacteria
CF59_RS15345	COG5445	Predicted secreted protein (DUF2300)
CF59_RS15350	COG2373	Large extracellular alpha-helical protein
CF59_RS15355	COG3234	Protein of unknown function (DUF1175)
CF59_RS15365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF59_RS15385	COG2801	Transposase and inactivated derivatives
CF59_RS15400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF59_RS15405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF59_RS15410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF59_RS15415	COG3642	lipopolysaccharide core region biosynthetic process
CF59_RS15420	COG2814	Major facilitator Superfamily
CF59_RS15425	COG0583	DNA-binding transcription factor activity
CF59_RS15430	COG0584	glycerophosphoryl diester phosphodiesterase
CF59_RS15435	COG2271	Major facilitator Superfamily
CF59_RS15440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CF59_RS15450	COG0247	lactate metabolic process
CF59_RS15455	COG5464	transposase or invertase
CF59_RS15470	COG2271	Major facilitator Superfamily
CF59_RS15480	COG1414	Transcriptional regulator
CF59_RS15545	COG0318	PFAM AMP-dependent synthetase and ligase
CF59_RS15555	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CF59_RS15570	COG1169	isochorismate synthase
CF59_RS15575	COG4575	ribosome binding
CF59_RS15580	COG2153	protein acetylation
CF59_RS15595	COG2234	aminopeptidase activity
CF59_RS15610	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF59_RS15615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CF59_RS15625	COG0839	Belongs to the complex I subunit 6 family
CF59_RS15640	COG1034	ATP synthesis coupled electron transport
CF59_RS15645	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CF59_RS15650	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CF59_RS15670	COG0583	DNA-binding transcription factor activity
CF59_RS15675	COG0436	Aminotransferase
CF59_RS15685	COG0490	domain, Protein
CF59_RS15685	COG0471	metal ion transport
CF59_RS15690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF59_RS15710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CF59_RS15715	COG0280	phosphate acetyltransferase
CF59_RS15715	COG0857	belongs to the CobB CobQ family
CF59_RS15720	COG1288	antiporter activity
CF59_RS15725	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CF59_RS15730	COG0622	Phosphoesterase
CF59_RS15735	COG0625	glutathione transferase activity
CF59_RS15740	COG0625	glutathione transferase activity
CF59_RS15745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CF59_RS15750	COG1090	epimerase
CF59_RS15755	COG5464	transposase or invertase
CF59_RS15760	COG4598	ABC transporter
CF59_RS15765	COG4160	amino acid transport
CF59_RS15770	COG4215	(ABC) transporter
CF59_RS15775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS15780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS15785	COG0163	prenyltransferase activity
CF59_RS15790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CF59_RS15795	COG1286	toxin biosynthetic process
CF59_RS15800	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CF59_RS15805	COG0285	dihydrofolate synthase activity
CF59_RS15815	COG0586	Pfam SNARE associated Golgi protein
CF59_RS15825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF59_RS15840	COG2814	Major facilitator Superfamily
CF59_RS15845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF59_RS15860	COG3101	peptidyl-lysine hydroxylation
CF59_RS15865	COG0730	response to heat
CF59_RS15890	COG2801	Transposase and inactivated derivatives
CF59_RS15910	COG3539	Fimbrial protein
CF59_RS15915	COG3539	Fimbrial protein
CF59_RS15920	COG3539	Fimbrial protein
CF59_RS15925	COG3121	Chaperone
CF59_RS15930	COG3188	usher protein
CF59_RS15935	COG3539	Fimbrial protein
CF59_RS15940	COG2062	phosphohistidine phosphatase, SixA
CF59_RS15955	COG3691	Protein conserved in bacteria
CF59_RS15960	COG2067	long-chain fatty acid transport protein
CF59_RS15970	COG2853	Lipoprotein
CF59_RS15975	COG2116	formate transmembrane transporter activity
CF59_RS15985	COG0582	viral genome integration into host DNA
CF59_RS16045	COG2610	gluconate transmembrane transporter activity
CF59_RS16055	COG0477	Major facilitator Superfamily
CF59_RS16060	COG1566	PFAM secretion protein HlyD family protein
CF59_RS16065	COG2197	response regulator
CF59_RS16070	COG2205	protein histidine kinase activity
CF59_RS16070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS16070	COG2198	Histidine kinase
CF59_RS16070	COG0784	Response regulator, receiver
CF59_RS16075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CF59_RS16080	COG0679	Auxin Efflux Carrier
CF59_RS16085	COG0028	Belongs to the TPP enzyme family
CF59_RS16115	COG1560	Kdo2-lipid A biosynthetic process
CF59_RS16120	COG0436	Aminotransferase
CF59_RS16125	COG3275	phosphorelay sensor kinase activity
CF59_RS16130	COG3279	Response regulator of the LytR AlgR family
CF59_RS16135	COG2207	Transcriptional regulator
CF59_RS16145	COG1363	Peptidase, m42
CF59_RS16150	COG0006	proline dipeptidase activity
CF59_RS16155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS16160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF59_RS16190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF59_RS16195	COG2200	EAL domain
CF59_RS16195	COG2199	diguanylate cyclase activity
CF59_RS16210	COG3415	Transposase
CF59_RS16215	COG3415	Transposase
CF59_RS16245	COG0583	DNA-binding transcription factor activity
CF59_RS16255	COG2211	Major facilitator Superfamily
CF59_RS16260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CF59_RS16270	COG0583	DNA-binding transcription factor activity
CF59_RS16275	COG0385	Bile acid
CF59_RS16280	COG3530	Putative quorum-sensing-regulated virulence factor
CF59_RS16300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CF59_RS16305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS16310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF59_RS16315	COG2190	(PTS) system
CF59_RS16330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CF59_RS16335	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CF59_RS16340	COG4208	sulfate ABC transporter
CF59_RS16345	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CF59_RS16350	COG4150	thiosulfate binding
CF59_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS16370	COG1263	PTS System
CF59_RS16370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS16375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF59_RS16380	COG2837	iron assimilation
CF59_RS16400	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF59_RS16410	COG2207	Transcriptional regulator
CF59_RS16415	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CF59_RS16420	COG4816	utilization protein
CF59_RS16430	COG4303	Ethanolamine ammonia lyase large subunit
CF59_RS16435	COG4819	ethanolamine utilization protein
CF59_RS16440	COG3192	ethanolamine utilization protein
CF59_RS16445	COG1454	alcohol dehydrogenase
CF59_RS16450	COG4820	ethanolamine utilization protein (EutJ)
CF59_RS16455	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS16460	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CF59_RS16465	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CF59_RS16470	COG0280	phosphate acetyltransferase
CF59_RS16475	COG4812	Cobalamin adenosyltransferase
CF59_RS16480	COG4766	ethanolamine catabolic process
CF59_RS16485	COG4917	ethanolamine utilization protein
CF59_RS16490	COG4810	utilization protein
CF59_RS16495	COG0281	malic enzyme
CF59_RS16495	COG0280	phosphate acetyltransferase
CF59_RS16500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF59_RS16505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CF59_RS16510	COG5342	invasion associated locus B
CF59_RS16520	COG0493	'glutamate synthase
CF59_RS16520	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS16525	COG3850	Histidine kinase
CF59_RS16530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF59_RS16540	COG1393	Belongs to the ArsC family
CF59_RS16565	COG2801	Transposase and inactivated derivatives
CF59_RS16570	COG0400	carboxylic ester hydrolase activity
CF59_RS16575	COG1444	tRNA N-acetyltransferase activity
CF59_RS16580	COG2321	neutral zinc metallopeptidase
CF59_RS16595	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CF59_RS16605	COG2716	regulation of RNA biosynthetic process
CF59_RS16610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CF59_RS16615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS16620	COG0651	ATP synthesis coupled electron transport
CF59_RS16625	COG0650	Formate hydrogenlyase subunit 4
CF59_RS16630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CF59_RS16635	COG4237	Hydrogenase 4 membrane
CF59_RS16640	COG0651	ATP synthesis coupled electron transport
CF59_RS16645	COG3261	NADH dehydrogenase
CF59_RS16645	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CF59_RS16650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF59_RS16655	COG3260	NADH ubiquinone oxidoreductase 20
CF59_RS16665	COG3604	Transcriptional regulator
CF59_RS16670	COG2116	formate transmembrane transporter activity
CF59_RS16675	COG0628	permease
CF59_RS16680	COG4783	chaperone-mediated protein folding
CF59_RS16685	COG1393	Belongs to the ArsC family
CF59_RS16695	COG2233	PERMEase
CF59_RS16710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CF59_RS16715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CF59_RS16720	COG0248	Ppx GppA phosphatase
CF59_RS16725	COG2200	EAL domain
CF59_RS16740	COG3133	Outer membrane lipoprotein
CF59_RS16755	COG0516	GMP reductase activity
CF59_RS16755	COG0517	IMP dehydrogenase activity
CF59_RS16780	COG1645	bacterial-type flagellum-dependent swarming motility
CF59_RS16795	COG2976	Protein conserved in bacteria
CF59_RS16825	COG4953	penicillin-binding protein 1C
CF59_RS16830	COG2373	Large extracellular alpha-helical protein
CF59_RS16835	COG2897	thiosulfate sulfurtransferase activity
CF59_RS16850	COG2975	iron-sulfur cluster assembly
CF59_RS16855	COG0633	Ferredoxin
CF59_RS16875	COG0822	iron-sulfur transferase activity
CF59_RS16895	COG0483	inositol monophosphate 1-phosphatase activity
CF59_RS16900	COG1073	alpha beta
CF59_RS16905	COG3711	transcriptional antiterminator
CF59_RS16910	COG2814	Major facilitator Superfamily
CF59_RS16915	COG0583	DNA-binding transcription factor activity
CF59_RS16920	COG4638	Rieske (2fe-2S)
CF59_RS16945	COG2259	Doxx family
CF59_RS16950	COG2017	converts alpha-aldose to the beta-anomer
CF59_RS16955	COG1063	alcohol dehydrogenase
CF59_RS16960	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF59_RS16965	COG1129	ABC transporter
CF59_RS16970	COG1879	ABC-type sugar transport system periplasmic component
CF59_RS16975	COG0457	Tetratricopeptide repeat
CF59_RS16980	COG1940	carbohydrate kinase activity
CF59_RS16995	COG1017	nitric oxide dioxygenase activity
CF59_RS16995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF59_RS17000	COG0347	Belongs to the P(II) protein family
CF59_RS17005	COG2204	response regulator
CF59_RS17010	COG3170	Tfp pilus assembly protein FimV
CF59_RS17015	COG2205	protein histidine kinase activity
CF59_RS17020	COG0047	phosphoribosylformylglycinamidine synthase activity
CF59_RS17020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CF59_RS17035	COG0560	Phosphoserine phosphatase
CF59_RS17040	COG1737	Transcriptional regulator
CF59_RS17045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS17070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CF59_RS17090	COG0681	Belongs to the peptidase S26 family
CF59_RS17100	COG3086	response to oxidative stress
CF59_RS17105	COG3026	antisigma factor binding
CF59_RS17110	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CF59_RS17115	COG1595	DNA-templated transcription, initiation
CF59_RS17125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CF59_RS17135	COG0513	Belongs to the DEAD box helicase family
CF59_RS17140	COG0583	DNA-binding transcription factor activity
CF59_RS17160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF59_RS17170	COG3118	belongs to the thioredoxin family
CF59_RS17175	COG3148	PFAM DTW domain containing protein
CF59_RS17180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF59_RS17180	COG0045	succinate-CoA ligase (ADP-forming) activity
CF59_RS17180	COG1042	CoA-binding domain protein
CF59_RS17185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF59_RS17190	COG5544	Lipoprotein
CF59_RS17195	COG0477	Major facilitator Superfamily
CF59_RS17200	COG2801	Transposase and inactivated derivatives
CF59_RS17235	COG0542	response to heat
CF59_RS17245	COG0564	pseudouridine synthase activity
CF59_RS17250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF59_RS17260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF59_RS17265	COG1605	Chorismate mutase
CF59_RS17265	COG0077	Prephenate dehydratase
CF59_RS17270	COG0287	Prephenate dehydrogenase
CF59_RS17270	COG1605	Chorismate mutase
CF59_RS17275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF59_RS17295	COG2885	chlorophyll binding
CF59_RS17320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CF59_RS17325	COG4137	Cytochrome C assembly protein
CF59_RS17330	COG4536	flavin adenine dinucleotide binding
CF59_RS17350	COG0497	DNA recombination
CF59_RS17355	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF59_RS17365	COG2867	negative regulation of translational initiation
CF59_RS17375	COG0582	viral genome integration into host DNA
CF59_RS17465	COG0366	Alpha amylase catalytic
CF59_RS17475	COG0579	oxidoreductase
CF59_RS17480	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS17485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CF59_RS17490	COG1113	amino acid transport
CF59_RS17495	COG1802	Transcriptional regulator
CF59_RS17500	COG1652	LysM domain
CF59_RS17505	COG0401	homolog of Blt101
CF59_RS17510	COG0640	Transcriptional regulator
CF59_RS17515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF59_RS17520	COG2916	Histone family protein nucleoid-structuring protein H-NS
CF59_RS17535	COG4575	ribosome binding
CF59_RS17540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF59_RS17545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF59_RS17550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF59_RS17560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF59_RS17565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF59_RS17570	COG4175	Glycine betaine
CF59_RS17575	COG4176	ABC-type proline glycine betaine transport system permease component
CF59_RS17580	COG2113	Glycine betaine
CF59_RS17585	COG2814	Major facilitator Superfamily
CF59_RS17590	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CF59_RS17600	COG1846	Transcriptional regulator
CF59_RS17605	COG1566	PFAM secretion protein HlyD family protein
CF59_RS17610	COG2814	Major facilitator Superfamily
CF59_RS17625	COG1238	metal cluster binding
CF59_RS17630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF59_RS17665	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CF59_RS17690	COG1546	Belongs to the CinA family
CF59_RS17695	COG2951	lytic endotransglycosylase activity
CF59_RS17700	COG3730	PTS system glucitol sorbitol-specific
CF59_RS17705	COG3732	PTS system glucitol sorbitol-specific
CF59_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS17720	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS17725	COG1349	DNA-binding transcription factor activity
CF59_RS17750	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CF59_RS17755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS17760	COG1609	Transcriptional regulator
CF59_RS17765	COG1263	PTS System
CF59_RS17765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS17770	COG2723	6-phospho-beta-galactosidase activity
CF59_RS17775	COG5499	transcription regulator containing HTH domain
CF59_RS17780	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF59_RS17790	COG3260	NADH ubiquinone oxidoreductase 20
CF59_RS17795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF59_RS17800	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CF59_RS17800	COG3261	NADH dehydrogenase
CF59_RS17805	COG0650	Formate hydrogenlyase subunit 4
CF59_RS17810	COG0651	ATP synthesis coupled electron transport
CF59_RS17815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS17830	COG0375	protein maturation
CF59_RS17835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CF59_RS17840	COG0298	carbon dioxide binding
CF59_RS17845	COG0409	Hydrogenase expression formation protein
CF59_RS17850	COG0309	Hydrogenase expression formation protein (HypE)
CF59_RS17855	COG3604	Transcriptional regulator
CF59_RS17880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CF59_RS17890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CF59_RS17895	COG0163	prenyltransferase activity
CF59_RS17905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF59_RS17910	COG4942	peptidase
CF59_RS17910	COG1388	LysM domain
CF59_RS17965	COG2234	aminopeptidase activity
CF59_RS17970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF59_RS17975	COG1518	maintenance of DNA repeat elements
CF59_RS17990	COG1857	crispr-associated protein
CF59_RS18005	COG1203	CRISPR-associated helicase, Cas3
CF59_RS18030	COG0720	synthase
CF59_RS18035	COG0644	oxidoreductase
CF59_RS18040	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF59_RS18045	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CF59_RS18050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CF59_RS18055	COG2086	electron transfer activity
CF59_RS18060	COG0477	Major facilitator Superfamily
CF59_RS18065	COG0277	FAD linked oxidase domain protein
CF59_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS18075	COG2223	nitrite transmembrane transporter activity
CF59_RS18085	COG0602	queuosine metabolic process
CF59_RS18095	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CF59_RS18110	COG3956	TIGRFAM MazG family protein
CF59_RS18115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF59_RS18125	COG2205	protein histidine kinase activity
CF59_RS18125	COG4999	Histidine kinase
CF59_RS18125	COG3850	Histidine kinase
CF59_RS18125	COG3437	response regulator, receiver
CF59_RS18130	COG4948	Mandelate Racemase Muconate Lactonizing
CF59_RS18135	COG4948	Mandelate Racemase Muconate Lactonizing
CF59_RS18140	COG2271	Major facilitator Superfamily
CF59_RS18145	COG0716	FMN binding
CF59_RS18150	COG0564	pseudouridine synthase activity
CF59_RS18155	COG3098	single-species biofilm formation
CF59_RS18175	COG1611	Belongs to the LOG family
CF59_RS18180	COG0814	amino acid
CF59_RS18185	COG1760	l-serine dehydratase
CF59_RS18195	COG1454	alcohol dehydrogenase
CF59_RS18200	COG0235	Class ii aldolase
CF59_RS18205	COG0738	Major facilitator superfamily
CF59_RS18215	COG1070	Carbohydrate kinase
CF59_RS18225	COG1349	DNA-binding transcription factor activity
CF59_RS18235	COG2363	Small membrane protein
CF59_RS18240	COG0583	DNA-binding transcription factor activity
CF59_RS18250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CF59_RS18255	COG2166	iron-sulfur cluster assembly
CF59_RS18260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CF59_RS18265	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CF59_RS18285	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF59_RS18290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CF59_RS18290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CF59_RS18295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CF59_RS18300	COG1074	ATP-dependent DNA helicase activity
CF59_RS18310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CF59_RS18315	COG4967	type IV pilus modification protein PilV
CF59_RS18325	COG4795	General secretion pathway protein
CF59_RS18330	COG2165	general secretion pathway protein
CF59_RS18345	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CF59_RS18370	COG0861	Integral membrane protein TerC family
CF59_RS18380	COG0667	Aldo Keto reductase
CF59_RS18395	COG1609	Transcriptional regulator
CF59_RS18405	COG0583	DNA-binding transcription factor activity
CF59_RS18410	COG1794	racemase activity, acting on amino acids and derivatives
CF59_RS18415	COG2814	Major facilitator Superfamily
CF59_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS18430	COG0183	Belongs to the thiolase family
CF59_RS18435	COG0814	amino acid
CF59_RS18440	COG2771	luxR family
CF59_RS18445	COG3710	Transcriptional regulator
CF59_RS18575	COG2207	Transcriptional regulator
CF59_RS18605	COG2207	Transcriptional regulator
CF59_RS18625	COG4942	peptidase
CF59_RS18630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF59_RS18635	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF59_RS18640	COG2080	2 iron, 2 sulfur cluster binding
CF59_RS18645	COG3829	transcription factor binding
CF59_RS18650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CF59_RS18655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF59_RS18660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CF59_RS18670	COG0549	Belongs to the carbamate kinase family
CF59_RS18675	COG3608	succinylglutamate desuccinylase aspartoacylase
CF59_RS18675	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CF59_RS18680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CF59_RS18685	COG2068	MobA-Related Protein
CF59_RS18690	COG0493	'glutamate synthase
CF59_RS18690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS18695	COG0402	S-adenosylhomocysteine deaminase activity
CF59_RS18700	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF59_RS18705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF59_RS18705	COG2080	2 iron, 2 sulfur cluster binding
CF59_RS18710	COG2233	PERMEase
CF59_RS18715	COG0402	S-adenosylhomocysteine deaminase activity
CF59_RS18720	COG2252	PERMEase
CF59_RS18725	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS18730	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS18730	COG0493	'glutamate synthase
CF59_RS18740	COG2233	PERMEase
CF59_RS18755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CF59_RS18765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CF59_RS18770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF59_RS18775	COG4974	Belongs to the 'phage' integrase family
CF59_RS18780	COG0716	FMN binding
CF59_RS18790	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CF59_RS18800	COG1272	protein, Hemolysin III
CF59_RS18810	COG2723	6-phospho-beta-galactosidase activity
CF59_RS18830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF59_RS18835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF59_RS18840	COG0006	proline dipeptidase activity
CF59_RS18855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CF59_RS18865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CF59_RS18880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF59_RS18880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF59_RS18885	COG1703	isobutyryl-CoA mutase activity
CF59_RS18895	COG0427	acetyl-CoA hydrolase
CF59_RS18900	COG0583	DNA-binding transcription factor activity
CF59_RS18905	COG2968	Membrane
CF59_RS18910	COG1279	arginine transmembrane transporter activity
CF59_RS18915	COG0668	transmembrane transport
CF59_RS18920	COG0191	fructose-bisphosphate aldolase activity
CF59_RS18935	COG1072	(Pantothenic acid kinase))
CF59_RS18945	COG1494	fructose-1,6-bisphosphatase
CF59_RS18950	COG1063	alcohol dehydrogenase
CF59_RS18955	COG2213	PTS system mannitol-specific
CF59_RS18960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS18965	COG0330	HflC and HflK could
CF59_RS18970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CF59_RS18975	COG0501	Belongs to the peptidase M48B family
CF59_RS18990	COG2801	Transposase and inactivated derivatives
CF59_RS19005	COG1166	arginine decarboxylase activity
CF59_RS19030	COG2814	Major facilitator Superfamily
CF59_RS19040	COG2356	endonuclease I
CF59_RS19045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CF59_RS19050	COG0189	ligase activity
CF59_RS19065	COG2805	Type II/IV secretion system protein
CF59_RS19070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CF59_RS19075	COG0762	integral membrane protein
CF59_RS19090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF59_RS19095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CF59_RS19100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CF59_RS19115	COG0252	asparaginase activity
CF59_RS19130	COG3171	Protein conserved in bacteria
CF59_RS19140	COG1194	a g-specific adenine glycosylase
CF59_RS19155	COG2211	Major facilitator Superfamily
CF59_RS19160	COG1982	Orn Lys Arg decarboxylase major
CF59_RS19165	COG1811	Na channel or pump
CF59_RS19225	COG0110	maltose O-acetyltransferase activity
CF59_RS19230	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CF59_RS19260	COG2165	general secretion pathway protein
CF59_RS19265	COG1459	type II secretion system
CF59_RS19270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF59_RS19290	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CF59_RS19295	COG3064	Membrane
CF59_RS19305	COG1620	l-lactate permease
CF59_RS19310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CF59_RS19315	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CF59_RS19320	COG0247	lactate metabolic process
CF59_RS19325	COG0277	FAD linked oxidase domain protein
CF59_RS19330	COG0277	FAD linked oxidase domain protein
CF59_RS19335	COG2186	Transcriptional regulator
CF59_RS19340	COG0456	acetyltransferase
CF59_RS19345	COG0318	PFAM AMP-dependent synthetase and ligase
CF59_RS19355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CF59_RS19360	COG0156	8-amino-7-oxononanoate synthase activity
CF59_RS19370	COG0795	lipopolysaccharide-transporting ATPase activity
CF59_RS19375	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CF59_RS19385	COG2244	polysaccharide biosynthetic process
CF59_RS19390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF59_RS19395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF59_RS19400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF59_RS19405	COG0306	phosphate transporter
CF59_RS19410	COG0754	glutathionylspermidine amidase activity
CF59_RS19415	COG0625	glutathione transferase activity
CF59_RS19420	COG0298	carbon dioxide binding
CF59_RS19430	COG1773	rubredoxin
CF59_RS19435	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF59_RS19440	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CF59_RS19445	COG5557	Pfam Polysulphide reductase, NrfD
CF59_RS19450	COG0437	4 iron, 4 sulfur cluster binding
CF59_RS19455	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CF59_RS19475	COG0667	Aldo Keto reductase
CF59_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
CF59_RS19490	COG0848	biopolymer transport protein
CF59_RS19495	COG0811	peptide transport
CF59_RS19505	COG0626	cystathionine gamma-synthase activity
CF59_RS19510	COG0586	Pfam SNARE associated Golgi protein
CF59_RS19515	COG2207	Transcriptional regulator
CF59_RS19525	COG1979	alcohol dehydrogenase
CF59_RS19530	COG0656	L-ascorbic acid biosynthetic process
CF59_RS19540	COG4238	major outer membrane lipoprotein
CF59_RS19545	COG1032	radical SAM domain protein
CF59_RS19550	COG2132	Multicopper oxidase
CF59_RS19555	COG0204	Acyl-transferase
CF59_RS19560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF59_RS19565	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CF59_RS19570	COG3111	PFAM Bacterial OB fold (BOF) protein
CF59_RS19575	COG0745	RESPONSE REGULATOR receiver
CF59_RS19580	COG0642	Histidine kinase
CF59_RS19600	COG2249	NAD(P)H dehydrogenase (quinone) activity
CF59_RS19605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CF59_RS19610	COG1737	Transcriptional regulator
CF59_RS19620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF59_RS19625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF59_RS19630	COG1120	ATPase activity
CF59_RS19635	COG4774	siderophore transport
CF59_RS19640	COG0187	DNA topoisomerase II activity
CF59_RS19645	COG3150	esterase
CF59_RS19650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CF59_RS19655	COG3151	Protein conserved in bacteria
CF59_RS19660	COG0494	nUDIX hydrolase
CF59_RS19665	COG1538	Outer membrane efflux protein
CF59_RS19680	COG0754	glutathionylspermidine amidase activity
CF59_RS19690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CF59_RS19695	COG2963	transposase activity
CF59_RS19700	COG2801	Transposase and inactivated derivatives
CF59_RS19710	COG3384	dioxygenase
CF59_RS19725	COG3539	Fimbrial protein
CF59_RS19730	COG3188	usher protein
CF59_RS19735	COG3121	Chaperone
CF59_RS19740	COG3539	Fimbrial protein
CF59_RS19760	COG1585	Membrane protein implicated in regulation of membrane protease activity
CF59_RS19765	COG2268	Band 7 protein
CF59_RS19785	COG3025	triphosphatase activity
CF59_RS19795	COG4991	sh3 domain protein
CF59_RS19810	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CF59_RS19825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF59_RS19830	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF59_RS19845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CF59_RS19850	COG0358	DNA primase activity
CF59_RS19855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF59_RS19870	COG2375	cellular response to nickel ion
CF59_RS19875	COG1695	Transcriptional regulator
CF59_RS19880	COG0840	transmembrane signaling receptor activity
CF59_RS19890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CF59_RS19895	COG1609	Transcriptional regulator
CF59_RS19900	COG3250	beta-galactosidase activity
CF59_RS19905	COG2731	YhcH YjgK YiaL family protein
CF59_RS19910	COG0531	amino acid
CF59_RS19920	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CF59_RS19920	COG3408	Glycogen debranching enzyme
CF59_RS19925	COG1902	pentaerythritol trinitrate reductase activity
CF59_RS19925	COG0446	pyridine nucleotide-disulphide oxidoreductase
CF59_RS19930	COG5499	transcription regulator containing HTH domain
CF59_RS19935	COG4680	protein conserved in bacteria
CF59_RS19950	COG1451	nucleotide metabolic process
CF59_RS19955	COG2949	membrane
CF59_RS19960	COG0673	inositol 2-dehydrogenase activity
CF59_RS19965	COG0861	Integral membrane protein TerC family
CF59_RS19970	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CF59_RS19980	COG2721	sulfolactate sulfo-lyase activity
CF59_RS19990	COG2271	Major facilitator Superfamily
CF59_RS19995	COG2186	Transcriptional regulator
CF59_RS20000	COG0586	Pfam SNARE associated Golgi protein
CF59_RS20010	COG1422	Protein of unknown function (DUF1090)
CF59_RS20015	COG4575	ribosome binding
CF59_RS20020	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CF59_RS20030	COG2259	Doxx family
CF59_RS20035	COG0435	Glutathione S-transferase
CF59_RS20045	COG3152	Membrane
CF59_RS20050	COG3152	Membrane
CF59_RS20055	COG0583	DNA-binding transcription factor activity
CF59_RS20060	COG1741	Belongs to the pirin family
CF59_RS20075	COG0814	amino acid
CF59_RS20080	COG1760	l-serine dehydratase
CF59_RS20085	COG0251	oxidation-reduction process
CF59_RS20090	COG1882	Formate acetyltransferase
CF59_RS20095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CF59_RS20105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF59_RS20110	COG0583	DNA-binding transcription factor activity
CF59_RS20135	COG1929	Belongs to the glycerate kinase type-1 family
CF59_RS20140	COG2084	Dehydrogenase
CF59_RS20150	COG2271	Major facilitator Superfamily
CF59_RS20155	COG2721	sulfolactate sulfo-lyase activity
CF59_RS20160	COG2002	toxin-antitoxin pair type II binding
CF59_RS20170	COG1349	DNA-binding transcription factor activity
CF59_RS20180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS20190	COG3716	PTS system mannose fructose sorbose family IID component
CF59_RS20195	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS20200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF59_RS20205	COG2222	sugar isomerase
CF59_RS20215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF59_RS20220	COG3715	PTS system
CF59_RS20225	COG3716	PTS system mannose fructose sorbose family IID component
CF59_RS20230	COG0363	glucosamine-6-phosphate deaminase activity
CF59_RS20235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CF59_RS20255	COG2823	Periplasmic or secreted lipoprotein
CF59_RS20260	COG0701	Predicted permease
CF59_RS20265	COG0702	epimerase
CF59_RS20270	COG0693	protein deglycase activity
CF59_RS20285	COG3153	acetyltransferase
CF59_RS20290	COG3154	lipid carrier protein
CF59_RS20295	COG0826	peptidase U32
CF59_RS20300	COG0826	peptidase U32
CF59_RS20305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CF59_RS20310	COG0814	amino acid
CF59_RS20320	COG0513	Belongs to the DEAD box helicase family
CF59_RS20355	COG0195	Participates in both transcription termination and antitermination
CF59_RS20375	COG2194	sulfuric ester hydrolase activity
CF59_RS20385	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF59_RS20395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CF59_RS20400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CF59_RS20410	COG1534	Rna-binding protein
CF59_RS20415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF59_RS20420	COG2027	D-alanyl-D-alanine carboxypeptidase
CF59_RS20430	COG0697	spore germination
CF59_RS20445	COG0142	geranyltranstransferase activity
CF59_RS20450	COG3423	Transcriptional regulator
CF59_RS20460	COG5007	Belongs to the BolA IbaG family
CF59_RS20465	COG3113	response to antibiotic
CF59_RS20470	COG2854	intermembrane phospholipid transfer
CF59_RS20475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CF59_RS20480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CF59_RS20485	COG1127	ABC transporter
CF59_RS20490	COG0530	calcium, potassium:sodium antiporter activity
CF59_RS20495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CF59_RS20495	COG0517	IMP dehydrogenase activity
CF59_RS20500	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CF59_RS20505	COG3117	lipopolysaccharide transmembrane transporter activity
CF59_RS20510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CF59_RS20515	COG1137	ATPase activity
CF59_RS20520	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CF59_RS20525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF59_RS20540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS20545	COG0515	serine threonine protein kinase
CF59_RS20555	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CF59_RS20560	COG2198	Histidine kinase
CF59_RS20560	COG5002	protein histidine kinase activity
CF59_RS20560	COG0784	Response regulator, receiver
CF59_RS20565	COG1242	4 iron, 4 sulfur cluster binding
CF59_RS20570	COG0070	glutamate synthase
CF59_RS20570	COG0069	glutamate synthase activity
CF59_RS20570	COG0067	glutamate synthase
CF59_RS20575	COG0493	'glutamate synthase
CF59_RS20580	COG4804	nuclease activity
CF59_RS20585	COG2731	YhcH YjgK YiaL family protein
CF59_RS20615	COG3069	C4-dicarboxylate transmembrane transporter activity
CF59_RS20620	COG2969	positive regulation of protein catabolic process
CF59_RS20625	COG0625	glutathione transferase activity
CF59_RS20640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CF59_RS20645	COG3105	Protein conserved in bacteria
CF59_RS20650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF59_RS20655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF59_RS20675	COG2732	(Barnase) inhibitor
CF59_RS20695	COG0583	DNA-binding transcription factor activity
CF59_RS20700	COG0312	modulator of DNA gyrase
CF59_RS20705	COG3164	Protein of unknown function
CF59_RS20710	COG1530	ribonuclease E activity
CF59_RS20720	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CF59_RS20725	COG1792	Involved in formation and maintenance of cell shape
CF59_RS20730	COG1077	Cell shape determining protein MreB Mrl
CF59_RS20740	COG2200	EAL domain
CF59_RS20740	COG2199	diguanylate cyclase activity
CF59_RS20745	COG0604	alcohol dehydrogenase
CF59_RS20770	COG0439	Biotin carboxylase
CF59_RS20775	COG3924	membrane
CF59_RS20780	COG4145	pantothenate transmembrane transporter activity
CF59_RS20790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF59_RS20800	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CF59_RS20810	COG1309	transcriptional regulator
CF59_RS20815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF59_RS20820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF59_RS20840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF59_RS20845	COG4597	amino acid ABC transporter
CF59_RS20850	COG0765	amino acid transport
CF59_RS20855	COG1126	abc transporter atp-binding protein
CF59_RS20895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF59_RS20915	COG0551	DNA topoisomerase type I activity
CF59_RS20925	COG0758	DNA mediated transformation
CF59_RS20945	COG0569	domain protein
CF59_RS20955	COG3036	rescue of stalled ribosome
CF59_RS20960	COG0789	Transcriptional regulator
CF59_RS21000	COG0201	protein transport
CF59_RS21090	COG0089	rRNA binding
CF59_RS21165	COG2964	Protein conserved in bacteria
CF59_RS21170	COG0545	Peptidyl-prolyl cis-trans isomerase
CF59_RS21180	COG1047	Peptidyl-prolyl cis-trans
CF59_RS21185	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CF59_RS21200	COG0488	(ABC) transporter
CF59_RS21205	COG0429	hydrolase of the alpha beta-hydrolase fold
CF59_RS21215	COG3954	Phosphoribulokinase
CF59_RS21220	COG1765	OsmC-like protein
CF59_RS21230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF59_RS21235	COG1289	transmembrane transporter activity
CF59_RS21240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CF59_RS21245	COG0512	Glutamine amidotransferase of anthranilate synthase
CF59_RS21250	COG2184	nucleotidyltransferase activity
CF59_RS21260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CF59_RS21270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CF59_RS21275	COG2146	nitrite reductase [NAD(P)H] activity
CF59_RS21280	COG2116	formate transmembrane transporter activity
CF59_RS21295	COG0626	cystathionine gamma-synthase activity
CF59_RS21310	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CF59_RS21315	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CF59_RS21320	COG3457	Alanine racemase
CF59_RS21330	COG2188	Transcriptional regulator
CF59_RS21335	COG0180	Tryptophanyl-tRNA synthetase
CF59_RS21345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CF59_RS21350	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CF59_RS21355	COG3266	domain, Protein
CF59_RS21370	COG4796	Type ii and iii secretion system protein
CF59_RS21385	COG3166	PFAM Fimbrial assembly family protein
CF59_RS21390	COG4972	Pilus assembly protein
CF59_RS21395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CF59_RS21400	COG0494	nUDIX hydrolase
CF59_RS21410	COG1011	Hydrolase
CF59_RS21415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CF59_RS21425	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CF59_RS21450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF59_RS21455	COG2183	response to ionizing radiation
CF59_RS21460	COG1918	ferrous iron import across plasma membrane
CF59_RS21465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CF59_RS21475	COG5464	transposase or invertase
CF59_RS21495	COG2610	gluconate transmembrane transporter activity
CF59_RS21500	COG1640	4-alpha-glucanotransferase
CF59_RS21505	COG0058	SHG alpha-glucan phosphorylase activity
CF59_RS21520	COG1690	Belongs to the RtcB family
CF59_RS21525	COG4650	regulator
CF59_RS21530	COG1349	DNA-binding transcription factor activity
CF59_RS21545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CF59_RS21565	COG3539	Fimbrial protein
CF59_RS21570	COG3188	usher protein
CF59_RS21575	COG3121	Chaperone
CF59_RS21585	COG0058	SHG alpha-glucan phosphorylase activity
CF59_RS21605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CF59_RS21610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF59_RS21615	COG2095	MarC family integral membrane protein
CF59_RS21620	COG2610	gluconate transmembrane transporter activity
CF59_RS21625	COG3265	gluconokinase activity
CF59_RS21630	COG1609	Transcriptional regulator
CF59_RS21635	COG1741	Belongs to the pirin family
CF59_RS21640	COG0673	inositol 2-dehydrogenase activity
CF59_RS21650	COG1247	-acetyltransferase
CF59_RS21655	COG3157	Type VI secretion system effector, Hcp
CF59_RS21670	COG0405	Gamma-glutamyltransferase
CF59_RS21680	COG0584	glycerophosphoryl diester phosphodiesterase
CF59_RS21695	COG1175	transmembrane transport
CF59_RS21700	COG1653	transport
CF59_RS21710	COG0410	ABC transporter
CF59_RS21715	COG0411	ABC transporter
CF59_RS21720	COG4177	L-phenylalanine transmembrane transporter activity
CF59_RS21725	COG0559	Belongs to the binding-protein-dependent transport system permease family
CF59_RS21730	COG0683	leucine binding
CF59_RS21735	COG0456	acetyltransferase
CF59_RS21745	COG0683	leucine binding
CF59_RS21750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF59_RS21755	COG2177	Part of the ABC transporter FtsEX involved in
CF59_RS21760	COG2884	Cell division ATP-binding protein ftsE
CF59_RS21765	COG0552	protein localization to endoplasmic reticulum
CF59_RS21770	COG0742	ribosomal rna small subunit methyltransferase
CF59_RS21775	COG3776	membrane
CF59_RS21785	COG3714	YhhN family
CF59_RS21800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CF59_RS21815	COG0628	permease
CF59_RS21820	COG2091	lysine biosynthetic process via aminoadipic acid
CF59_RS21825	COG0747	negative chemotaxis
CF59_RS21830	COG0601	transmembrane transport
CF59_RS21835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF59_RS21855	COG3209	COG3209 Rhs family protein
CF59_RS21875	COG3209	COG3209 Rhs family protein
CF59_RS21885	COG1413	lyase activity
CF59_RS21890	COG3209	COG3209 Rhs family protein
CF59_RS21895	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF59_RS21900	COG5433	transposase activity
CF59_RS21905	COG0842	Transport permease protein
CF59_RS21910	COG1129	ABC transporter
CF59_RS21910	COG0842	Transport permease protein
CF59_RS21915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF59_RS21945	COG2081	HI0933 family
CF59_RS21950	COG0306	phosphate transporter
CF59_RS21960	COG0589	response to stress
CF59_RS21965	COG3104	oligopeptide transport
CF59_RS21975	COG0339	signal peptide processing
CF59_RS21980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CF59_RS21985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF59_RS22000	COG0640	Transcriptional regulator
CF59_RS22005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CF59_RS22010	COG1393	Belongs to the ArsC family
CF59_RS22030	COG3065	identical protein binding
CF59_RS22035	COG2197	response regulator
CF59_RS22040	COG3720	iron ion transport
CF59_RS22045	COG4771	TonB-dependent receptor
CF59_RS22050	COG4558	Periplasmic binding protein
CF59_RS22060	COG3721	Heme iron utilization protein
CF59_RS22070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF59_RS22080	COG1285	pathogenesis
CF59_RS22095	COG3247	response to pH
CF59_RS22100	COG2771	luxR family
CF59_RS22110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF59_RS22115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF59_RS22120	COG2207	Transcriptional regulator
CF59_RS22125	COG2207	Transcriptional regulator
CF59_RS22130	COG0076	glutamate decarboxylase activity
CF59_RS22135	COG1858	cytochrome C peroxidase
CF59_RS22145	COG2197	response regulator
CF59_RS22150	COG0583	DNA-binding transcription factor activity
CF59_RS22155	COG1295	ribonuclease BN
CF59_RS22160	COG0477	Major facilitator Superfamily
CF59_RS22165	COG2982	Protein involved in outer membrane biogenesis
CF59_RS22170	COG2200	EAL domain
CF59_RS22180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF59_RS22185	COG0612	Peptidase, M16
CF59_RS22195	COG2200	EAL domain
CF59_RS22195	COG2199	diguanylate cyclase activity
CF59_RS22200	COG0457	Tetratricopeptide repeat
CF59_RS22200	COG3118	belongs to the thioredoxin family
CF59_RS22205	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CF59_RS22210	COG1215	transferase activity, transferring glycosyl groups
CF59_RS22215	COG1215	transferase activity, transferring glycosyl groups
CF59_RS22240	COG2194	sulfuric ester hydrolase activity
CF59_RS22260	COG0814	amino acid
CF59_RS22265	COG4608	Belongs to the ABC transporter superfamily
CF59_RS22270	COG0444	Belongs to the ABC transporter superfamily
CF59_RS22275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF59_RS22280	COG0601	transmembrane transport
CF59_RS22290	COG0747	negative chemotaxis
CF59_RS22305	COG2194	sulfuric ester hydrolase activity
CF59_RS22310	COG2223	nitrite transmembrane transporter activity
CF59_RS22315	COG5571	outer membrane autotransporter
CF59_RS22320	COG2818	Glycosylase
CF59_RS22325	COG0456	acetyltransferase
CF59_RS22330	COG0243	molybdopterin cofactor binding
CF59_RS22335	COG2885	chlorophyll binding
CF59_RS22350	COG2944	sequence-specific DNA binding
CF59_RS22355	COG1278	Cold shock
CF59_RS22365	COG2801	Transposase and inactivated derivatives
CF59_RS22370	COG2963	transposase activity
CF59_RS22390	COG3274	enterobacterial common antigen metabolic process
CF59_RS22395	COG4682	membrane
CF59_RS22400	COG4682	membrane
CF59_RS22405	COG1070	Carbohydrate kinase
CF59_RS22415	COG4213	ABC transporter substrate-binding protein
CF59_RS22425	COG4214	carbohydrate transport
CF59_RS22430	COG1609	Transcriptional regulator
CF59_RS22430	COG2207	Transcriptional regulator
CF59_RS22435	COG2992	FlgJ-related protein
CF59_RS22440	COG0366	Alpha amylase catalytic
CF59_RS22445	COG3977	Valine--pyruvate aminotransferase
CF59_RS22455	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF59_RS22460	COG1414	Transcriptional regulator
CF59_RS22470	COG2731	YhcH YjgK YiaL family protein
CF59_RS22475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CF59_RS22480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CF59_RS22485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CF59_RS22490	COG1070	Carbohydrate kinase
CF59_RS22495	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CF59_RS22500	COG3623	hexulose-6-phosphate isomerase
CF59_RS22505	COG0235	Class ii aldolase
CF59_RS22515	COG2211	Major facilitator Superfamily
CF59_RS22545	COG1012	belongs to the aldehyde dehydrogenase family
CF59_RS22555	COG1454	alcohol dehydrogenase
CF59_RS22560	COG3276	selenocysteine insertion sequence binding
CF59_RS22570	COG0625	glutathione transferase activity
CF59_RS22590	COG1566	PFAM secretion protein HlyD family protein
CF59_RS22600	COG2213	PTS system mannitol-specific
CF59_RS22600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF59_RS22610	COG3722	fumarate hydratase activity
CF59_RS22630	COG5295	Hep Hag repeat protein
CF59_RS22635	COG1620	l-lactate permease
CF59_RS22640	COG2186	Transcriptional regulator
CF59_RS22650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CF59_RS22655	COG1045	serine acetyltransferase
CF59_RS22670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF59_RS22675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF59_RS22685	COG4942	peptidase
CF59_RS22690	COG2861	carbohydrate metabolic process
CF59_RS22695	COG1216	Glycosyl transferase, family 2
CF59_RS22705	COG0156	8-amino-7-oxononanoate synthase activity
CF59_RS22715	COG0859	PFAM glycosyl transferase family 9
CF59_RS22720	COG0859	PFAM glycosyl transferase family 9
CF59_RS22735	COG1442	glycosyl transferase family 8
CF59_RS22740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CF59_RS22755	COG0515	serine threonine protein kinase
CF59_RS22760	COG0438	transferase activity, transferring glycosyl groups
CF59_RS22765	COG0859	PFAM glycosyl transferase family 9
CF59_RS22770	COG1519	Transferase
CF59_RS22780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CF59_RS22800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CF59_RS22825	COG1561	YicC-like family, N-terminal region
CF59_RS22830	COG3645	SOS response
CF59_RS22835	COG2860	membrane
CF59_RS22845	COG0194	GDP metabolic process
CF59_RS22855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF59_RS22860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF59_RS22865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CF59_RS22875	COG0786	glutamate:sodium symporter activity
CF59_RS22880	COG2233	PERMEase
CF59_RS22885	COG2982	Protein involved in outer membrane biogenesis
CF59_RS22890	COG1501	Belongs to the glycosyl hydrolase 31 family
CF59_RS22895	COG2211	Major facilitator Superfamily
CF59_RS22905	COG0582	viral genome integration into host DNA
CF59_RS22965	COG2814	Major facilitator Superfamily
CF59_RS22970	COG0697	spore germination
CF59_RS22975	COG1464	Belongs to the NlpA lipoprotein family
CF59_RS23000	COG2252	PERMEase
CF59_RS23010	COG2271	Major facilitator Superfamily
CF59_RS23015	COG2271	Major facilitator Superfamily
CF59_RS23020	COG3851	Histidine kinase
CF59_RS23025	COG2197	response regulator
CF59_RS23045	COG0440	acetolactate synthase activity
CF59_RS23050	COG0028	Belongs to the TPP enzyme family
CF59_RS23075	COG2814	Major facilitator Superfamily
CF59_RS23080	COG0641	radical SAM
CF59_RS23090	COG2149	membrane
CF59_RS23095	COG3119	arylsulfatase activity
CF59_RS23100	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF59_RS23105	COG2207	Transcriptional regulator
CF59_RS23120	COG2188	Transcriptional regulator
CF59_RS23145	COG5645	(Lipo)protein
CF59_RS23150	COG0823	Involved in the tonB-independent uptake of proteins
CF59_RS23160	COG2271	Major facilitator Superfamily
CF59_RS23170	COG0800	Aldolase
CF59_RS23175	COG3734	2-keto-3-deoxy-galactonokinase
CF59_RS23180	COG2186	Transcriptional regulator
CF59_RS23190	COG0561	phosphatase activity
CF59_RS23195	COG3753	Protein conserved in bacteria
CF59_RS23200	COG0187	DNA topoisomerase II activity
CF59_RS23210	COG0592	DNA-directed DNA polymerase activity
CF59_RS23260	COG0814	amino acid
CF59_RS23275	COG2091	lysine biosynthetic process via aminoadipic acid
CF59_RS23280	COG0431	NADPH-dependent FMN reductase
CF59_RS23285	COG2252	PERMEase
CF59_RS23290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF59_RS23325	COG0704	Plays a role in the regulation of phosphate uptake
CF59_RS23330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CF59_RS23335	COG0581	inorganic phosphate transmembrane transporter activity
CF59_RS23340	COG0573	inorganic phosphate transmembrane transporter activity
CF59_RS23345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CF59_RS23370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CF59_RS23420	COG3312	ion transport
CF59_RS23435	COG0716	FMN binding
CF59_RS23440	COG1522	sequence-specific DNA binding
CF59_RS23470	COG1129	ABC transporter
CF59_RS23475	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF59_RS23480	COG1879	ABC-type sugar transport system periplasmic component
CF59_RS23485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF59_RS23490	COG1609	Transcriptional regulator
CF59_RS23495	COG0477	Major facilitator Superfamily
CF59_RS23500	COG2186	Transcriptional regulator
CF59_RS23540	COG3085	chromosome segregation
CF59_RS23545	COG0606	chelatase, subunit chli
CF59_RS23560	COG3978	acetolactate synthase activity
CF59_RS23565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CF59_RS23575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF59_RS23580	COG0583	DNA-binding transcription factor activity
CF59_RS23590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF59_RS23595	COG3692	DNA binding
CF59_RS23600	COG0210	DNA helicase
CF59_RS23615	COG3118	belongs to the thioredoxin family
CF59_RS23625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CF59_RS23640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CF59_RS23645	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF59_RS23650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CF59_RS23655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CF59_RS23660	COG0456	acetyltransferase
CF59_RS23665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CF59_RS23670	COG2244	polysaccharide biosynthetic process
CF59_RS23690	COG1113	amino acid transport
CF59_RS23715	COG0641	radical SAM
CF59_RS23720	COG3119	arylsulfatase activity
CF59_RS23725	COG3071	HemY protein
CF59_RS23730	COG2959	enzyme of heme biosynthesis
CF59_RS23735	COG1587	Uroporphyrinogen-III synthase
CF59_RS23745	COG3072	Adenylate cyclase
CF59_RS23755	COG5567	small periplasmic lipoprotein
CF59_RS23765	COG3159	Protein conserved in bacteria
CF59_RS23775	COG1011	Hydrolase
CF59_RS23780	COG0210	DNA helicase
CF59_RS23785	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CF59_RS23790	COG3698	Phosphodiester glycosidase
CF59_RS23800	COG0598	Magnesium transport protein CorA
CF59_RS23815	COG2962	Rard protein
CF59_RS23820	COG2050	protein possibly involved in aromatic compounds catabolism
CF59_RS23825	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CF59_RS23830	COG0514	ATP-dependent DNA helicase (RecQ)
CF59_RS23835	COG1280	lysine exporter protein (LysE YggA)
CF59_RS23840	COG1280	lysine exporter protein (LysE YggA)
CF59_RS23845	COG2267	carboxylic ester hydrolase activity
CF59_RS23850	COG0561	phosphatase activity
CF59_RS23855	COG0697	spore germination
CF59_RS23860	COG0583	DNA-binding transcription factor activity
CF59_RS23865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CF59_RS23880	COG3157	Type VI secretion system effector, Hcp
CF59_RS23885	COG0412	Dienelactone hydrolase
CF59_RS23890	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CF59_RS23895	COG1322	Protein conserved in bacteria
CF59_RS23905	COG3165	ubiquinone biosynthetic process from chorismate
CF59_RS23915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF59_RS23920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF59_RS23925	COG0805	protein transport
CF59_RS23935	COG0250	Participates in transcription elongation, termination and antitermination
CF59_RS23940	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CF59_RS23945	COG0543	2 iron, 2 sulfur cluster binding
CF59_RS23965	COG1739	Uncharacterized protein family UPF0029
CF59_RS23970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CF59_RS23975	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CF59_RS24015	COG0741	lytic transglycosylase activity
CF59_RS24100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF59_RS24115	COG0741	lytic transglycosylase activity
CF59_RS24130	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF59_RS24160	COG0456	acetyltransferase
CF59_RS24200	COG3084	Protein conserved in bacteria
CF59_RS24205	COG0746	molybdenum cofactor guanylyltransferase activity
CF59_RS24215	COG2801	Transposase and inactivated derivatives
CF59_RS24290	COG3209	COG3209 Rhs family protein
CF59_RS24295	COG5433	transposase activity
CF59_RS24385	COG4917	ethanolamine utilization protein