locus-tag	class	description
CF60_RS00045	COG1763	Mo-molybdopterin cofactor biosynthetic process
CF60_RS00050	COG0746	molybdenum cofactor guanylyltransferase activity
CF60_RS00055	COG3084	Protein conserved in bacteria
CF60_RS00060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CF60_RS00065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF60_RS00070	COG5339	Protein conserved in bacteria
CF60_RS00075	COG0204	Acyl-transferase
CF60_RS00100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF60_RS00110	COG2204	response regulator
CF60_RS00115	COG3852	Histidine kinase
CF60_RS00120	COG0174	glutamine synthetase
CF60_RS00130	COG1217	gtp-binding protein TYPA
CF60_RS00135	COG2188	Transcriptional regulator
CF60_RS00140	COG1082	Xylose isomerase domain protein TIM barrel
CF60_RS00145	COG2271	Major facilitator Superfamily
CF60_RS00150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF60_RS00155	COG2211	Major facilitator Superfamily
CF60_RS00160	COG2211	Major facilitator Superfamily
CF60_RS00165	COG1501	Belongs to the glycosyl hydrolase 31 family
CF60_RS00175	COG2017	converts alpha-aldose to the beta-anomer
CF60_RS00180	COG2942	2-epimerase
CF60_RS00185	COG3684	Belongs to the aldolase LacD family
CF60_RS00190	COG2084	Dehydrogenase
CF60_RS00195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF60_RS00200	COG1349	DNA-binding transcription factor activity
CF60_RS00205	COG1011	Hydrolase
CF60_RS00220	COG0456	acetyltransferase
CF60_RS00235	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CF60_RS00245	COG2864	formate dehydrogenase
CF60_RS00250	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS00255	COG3383	formate dehydrogenase (NAD+) activity
CF60_RS00255	COG0243	molybdopterin cofactor binding
CF60_RS00260	COG3383	formate dehydrogenase (NAD+) activity
CF60_RS00260	COG0243	molybdopterin cofactor binding
CF60_RS00275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS00275	COG3711	transcriptional antiterminator
CF60_RS00280	COG1363	Peptidase, m42
CF60_RS00285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS00285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS00290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS00340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CF60_RS00355	COG2258	MOSC domain
CF60_RS00370	COG2801	Transposase and inactivated derivatives
CF60_RS00375	COG2205	protein histidine kinase activity
CF60_RS00380	COG0745	RESPONSE REGULATOR receiver
CF60_RS00385	COG3678	ATP-independent chaperone mediated protein folding
CF60_RS00400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CF60_RS00420	COG3152	Membrane
CF60_RS00425	COG3691	Protein conserved in bacteria
CF60_RS00430	COG0589	response to stress
CF60_RS00440	COG1494	fructose-1,6-bisphosphatase
CF60_RS00450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CF60_RS00465	COG1575	Belongs to the MenA family. Type 1 subfamily
CF60_RS00480	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF60_RS00485	COG1609	Transcriptional regulator
CF60_RS00490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CF60_RS00505	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF60_RS00515	COG5433	transposase activity
CF60_RS00525	COG3209	COG3209 Rhs family protein
CF60_RS00550	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CF60_RS00560	COG0626	cystathionine gamma-synthase activity
CF60_RS00565	COG0527	aspartate kinase activity
CF60_RS00565	COG0460	homoserine dehydrogenase
CF60_RS00575	COG0737	Belongs to the 5'-nucleotidase family
CF60_RS00580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CF60_RS00590	COG0697	spore germination
CF60_RS00595	COG3738	Protein conserved in bacteria
CF60_RS00600	COG0371	Dehydrogenase
CF60_RS00605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF60_RS00610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS00610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF60_RS00610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS00615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS00620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS00625	COG1882	Formate acetyltransferase
CF60_RS00630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF60_RS00635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS00640	COG2207	Transcriptional regulator
CF60_RS00660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CF60_RS00675	COG0583	DNA-binding transcription factor activity
CF60_RS00700	COG4206	TonB-dependent receptor
CF60_RS00735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CF60_RS00740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CF60_RS00740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CF60_RS00780	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF60_RS00785	COG0250	Participates in transcription elongation, termination and antitermination
CF60_RS00820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CF60_RS00830	COG2104	thiamine diphosphate biosynthetic process
CF60_RS00835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CF60_RS00870	COG3068	Protein conserved in bacteria
CF60_RS00885	COG3678	ATP-independent chaperone mediated protein folding
CF60_RS00890	COG4191	Histidine kinase
CF60_RS00895	COG2204	response regulator
CF60_RS00900	COG0151	Belongs to the GarS family
CF60_RS00935	COG0456	acetyltransferase
CF60_RS00945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CF60_RS00950	COG2224	Isocitrate lyase
CF60_RS00965	COG1414	Transcriptional regulator
CF60_RS00970	COG0646	methionine synthase
CF60_RS00970	COG1410	methionine synthase
CF60_RS00985	COG1283	sodium-dependent phosphate transmembrane transporter activity
CF60_RS01035	COG1187	pseudouridine synthase activity
CF60_RS01045	COG0527	aspartate kinase activity
CF60_RS01070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF60_RS01090	COG2814	Major facilitator Superfamily
CF60_RS01090	COG0477	Major facilitator Superfamily
CF60_RS01095	COG3833	ABC-type maltose transport systems, permease component
CF60_RS01100	COG1175	transmembrane transport
CF60_RS01105	COG2182	Extracellular solute-binding protein
CF60_RS01115	COG3842	ATPase activity
CF60_RS01130	COG1357	PFAM Pentapeptide repeats (8 copies)
CF60_RS01150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CF60_RS01160	COG0534	Mate efflux family protein
CF60_RS01165	COG3237	CsbD-like
CF60_RS01170	COG0735	belongs to the Fur family
CF60_RS01185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF60_RS01195	COG0604	alcohol dehydrogenase
CF60_RS01200	COG0305	Participates in initiation and elongation during chromosome replication
CF60_RS01205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CF60_RS01210	COG1448	Aminotransferase
CF60_RS01220	COG3700	Belongs to the class B bacterial acid phosphatase family
CF60_RS01225	COG0432	Pfam Uncharacterised protein family UPF0047
CF60_RS01230	COG2315	Protein conserved in bacteria
CF60_RS01235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CF60_RS01240	COG0629	single-stranded DNA binding
CF60_RS01250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CF60_RS01255	COG2207	Transcriptional regulator
CF60_RS01260	COG0789	Transcriptional regulator
CF60_RS01265	COG2252	PERMEase
CF60_RS01270	COG0025	NhaP-type Na H and K H
CF60_RS01275	COG1357	PFAM Pentapeptide repeats (8 copies)
CF60_RS01285	COG3162	membrane
CF60_RS01290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF60_RS01300	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CF60_RS01305	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS01310	COG3301	Polysulphide reductase, NrfD
CF60_RS01315	COG1138	Cytochrome C-type biogenesis protein
CF60_RS01320	COG3088	subunit of a heme lyase
CF60_RS01325	COG4235	cytochrome complex assembly
CF60_RS01330	COG1301	dicarboxylic acid transport
CF60_RS01335	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF60_RS01340	COG3383	formate dehydrogenase (NAD+) activity
CF60_RS01345	COG3383	formate dehydrogenase (NAD+) activity
CF60_RS01355	COG1289	transmembrane transporter activity
CF60_RS01360	COG1566	PFAM secretion protein HlyD family protein
CF60_RS01370	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CF60_RS01375	COG1940	carbohydrate kinase activity
CF60_RS01380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CF60_RS01385	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF60_RS01390	COG1129	ABC transporter
CF60_RS01395	COG1879	ABC-type sugar transport system periplasmic component
CF60_RS01400	COG1737	Transcriptional regulator
CF60_RS01405	COG0698	ribose 5-phosphate isomerase
CF60_RS01415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CF60_RS01420	COG0456	acetyltransferase
CF60_RS01430	COG3454	Phosphonate metabolism
CF60_RS01435	COG4778	phosphonate C-P lyase system protein PhnL
CF60_RS01440	COG4107	phosphonate C-P lyase system protein PhnK
CF60_RS01445	COG3627	carbon phosphorus lyase activity
CF60_RS01450	COG3626	phosphonate metabolism
CF60_RS01455	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CF60_RS01460	COG3624	Phosphonate C-P lyase system protein PhnG
CF60_RS01465	COG2188	Transcriptional regulator
CF60_RS01470	COG3639	organic phosphonate transmembrane transporter activity
CF60_RS01475	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CF60_RS01485	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CF60_RS01490	COG2824	Alkylphosphonate utilization operon protein PhnA
CF60_RS01505	COG0477	Major facilitator Superfamily
CF60_RS01515	COG0642	Histidine kinase
CF60_RS01520	COG0745	RESPONSE REGULATOR receiver
CF60_RS01525	COG2194	sulfuric ester hydrolase activity
CF60_RS01530	COG0531	amino acid
CF60_RS01535	COG2207	Transcriptional regulator
CF60_RS01540	COG1982	Orn Lys Arg decarboxylase major
CF60_RS01545	COG2169	Transcriptional regulator
CF60_RS01555	COG1486	melibiose metabolic process
CF60_RS01560	COG2211	Major facilitator Superfamily
CF60_RS01570	COG3647	Membrane
CF60_RS01575	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF60_RS01575	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF60_RS01580	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF60_RS01590	COG4565	transcriptional regulatory protein
CF60_RS01595	COG3290	protein histidine kinase activity
CF60_RS01600	COG3592	Divergent 4Fe-4S mono-cluster
CF60_RS01605	COG2388	GCN5-related N-acetyl-transferase
CF60_RS01620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CF60_RS01625	COG3104	oligopeptide transport
CF60_RS01630	COG1982	Orn Lys Arg decarboxylase major
CF60_RS01635	COG0531	amino acid
CF60_RS01640	COG3710	Transcriptional regulator
CF60_RS01650	COG1309	transcriptional regulator
CF60_RS01655	COG4232	protein-disulfide reductase activity
CF60_RS01665	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF60_RS01670	COG1027	Aspartate ammonia-lyase
CF60_RS01675	COG3030	protein affecting phage T7 exclusion by the F plasmid
CF60_RS01680	COG0531	amino acid
CF60_RS01705	COG1509	lysine 2,3-aminomutase activity
CF60_RS01715	COG5510	response to toxic substance
CF60_RS01720	COG5510	response to toxic substance
CF60_RS01725	COG2076	Multidrug Resistance protein
CF60_RS01730	COG3040	lipid binding
CF60_RS01735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF60_RS01750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CF60_RS01755	COG1053	succinate dehydrogenase
CF60_RS01765	COG0531	amino acid
CF60_RS01770	COG3264	Mechanosensitive ion channel
CF60_RS01770	COG1511	domain protein
CF60_RS01810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CF60_RS01810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CF60_RS01815	COG0802	atpase or kinase
CF60_RS01820	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF60_RS01840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CF60_RS01845	COG0330	HflC and HflK could
CF60_RS01850	COG0330	HflC and HflK could
CF60_RS01855	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CF60_RS01870	COG0557	exoribonuclease II activity
CF60_RS01875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF60_RS01880	COG3789	protein conserved in bacteria
CF60_RS01885	COG1842	Phage shock protein A
CF60_RS01895	COG3766	membrane
CF60_RS01900	COG5463	Belongs to the UPF0441 family
CF60_RS01905	COG0754	glutathionylspermidine amidase activity
CF60_RS01910	COG1960	acyl-CoA dehydrogenase activity
CF60_RS01920	COG3650	response to hydrogen peroxide
CF60_RS01925	COG1073	alpha beta
CF60_RS01940	COG3037	sugar-specific permease SgaT UlaA
CF60_RS01985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CF60_RS02000	COG1309	transcriptional regulator
CF60_RS02005	COG3061	Opacity-associated protein A
CF60_RS02010	COG0545	Peptidyl-prolyl cis-trans isomerase
CF60_RS02025	COG0697	spore germination
CF60_RS02030	COG0702	epimerase
CF60_RS02040	COG0737	Belongs to the 5'-nucleotidase family
CF60_RS02045	COG1218	3'(2'),5'-bisphosphate nucleotidase
CF60_RS02055	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CF60_RS02065	COG1253	flavin adenine dinucleotide binding
CF60_RS02080	COG0729	surface antigen
CF60_RS02085	COG2911	Protein conserved in bacteria
CF60_RS02090	COG2105	PFAM AIG2 family protein
CF60_RS02095	COG2336	PFAM SpoVT AbrB
CF60_RS02100	COG2337	Toxic component of a toxin-antitoxin (TA) module
CF60_RS02105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CF60_RS02110	COG1879	ABC-type sugar transport system periplasmic component
CF60_RS02115	COG1129	ABC transporter
CF60_RS02120	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF60_RS02125	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF60_RS02135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CF60_RS02145	COG0312	modulator of DNA gyrase
CF60_RS02150	COG3783	Cytochrome b(562)
CF60_RS02155	COG3077	Addiction module antitoxin, RelB DinJ family
CF60_RS02160	COG2026	Addiction module toxin, RelE StbE family
CF60_RS02165	COG0602	queuosine metabolic process
CF60_RS02175	COG1328	CTP reductase activity
CF60_RS02180	COG0366	Alpha amylase catalytic
CF60_RS02185	COG1263	PTS System
CF60_RS02185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS02190	COG1263	PTS System
CF60_RS02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS02195	COG1609	Transcriptional regulator
CF60_RS02200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CF60_RS02205	COG0251	oxidation-reduction process
CF60_RS02230	COG0251	oxidation-reduction process
CF60_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS02240	COG1309	transcriptional regulator
CF60_RS02245	COG2731	YhcH YjgK YiaL family protein
CF60_RS02260	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CF60_RS02265	COG0456	acetyltransferase
CF60_RS02270	COG4269	membrane
CF60_RS02280	COG2927	DNA polymerase III (CHI subunit)
CF60_RS02290	COG0795	lipopolysaccharide-transporting ATPase activity
CF60_RS02295	COG0795	lipopolysaccharide-transporting ATPase activity
CF60_RS02300	COG0433	COG0433 Predicted ATPase
CF60_RS02305	COG1064	alcohol dehydrogenase
CF60_RS02315	COG0582	viral genome integration into host DNA
CF60_RS02320	COG2801	Transposase and inactivated derivatives
CF60_RS02325	COG2963	transposase activity
CF60_RS02375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CF60_RS02420	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF60_RS02435	COG0582	viral genome integration into host DNA
CF60_RS02440	COG4974	Belongs to the 'phage' integrase family
CF60_RS02455	COG3539	Fimbrial protein
CF60_RS02460	COG3121	Chaperone
CF60_RS02465	COG3188	usher protein
CF60_RS02470	COG3539	Fimbrial protein
CF60_RS02475	COG3539	Fimbrial protein
CF60_RS02480	COG3539	Fimbrial protein
CF60_RS02485	COG2610	gluconate transmembrane transporter activity
CF60_RS02500	COG0246	Mannitol dehydrogenase
CF60_RS02510	COG2186	Transcriptional regulator
CF60_RS02530	COG0583	DNA-binding transcription factor activity
CF60_RS02535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF60_RS02540	COG0700	Nucleoside recognition
CF60_RS02545	COG3366	ferrous iron transmembrane transporter activity
CF60_RS02560	COG0477	Major facilitator Superfamily
CF60_RS02565	COG3204	pilus organization
CF60_RS02580	COG1924	4 iron, 4 sulfur cluster binding
CF60_RS02585	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CF60_RS02590	COG2733	membrane
CF60_RS02595	COG2814	Major facilitator Superfamily
CF60_RS02605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF60_RS02610	COG5457	Domain of unknown function (DUF1127)
CF60_RS02625	COG0732	type I restriction modification DNA specificity domain
CF60_RS02650	COG0523	cobalamin synthesis protein
CF60_RS02655	COG2879	small protein
CF60_RS02660	COG1966	Carbon starvation protein
CF60_RS02670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CF60_RS02675	COG2368	4-hydroxyphenylacetate
CF60_RS02680	COG1234	tRNA 3'-trailer cleavage
CF60_RS02700	COG3971	2-oxopent-4-enoate hydratase activity
CF60_RS02710	COG3384	dioxygenase
CF60_RS02715	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS02720	COG0179	Fumarylacetoacetate (FAA) hydrolase
CF60_RS02725	COG1846	Transcriptional regulator
CF60_RS02730	COG0840	transmembrane signaling receptor activity
CF60_RS02735	COG2271	Major facilitator Superfamily
CF60_RS02740	COG1802	Transcriptional regulator
CF60_RS02745	COG1063	alcohol dehydrogenase
CF60_RS02760	COG1484	DNA-dependent DNA replication
CF60_RS02775	COG2966	Psort location CytoplasmicMembrane, score
CF60_RS02780	COG2197	response regulator
CF60_RS02785	COG2197	response regulator
CF60_RS02790	COG4114	ferric iron reductase
CF60_RS02825	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CF60_RS02830	COG0456	acetyltransferase
CF60_RS02835	COG1011	Hydrolase
CF60_RS02845	COG2823	Periplasmic or secreted lipoprotein
CF60_RS02855	COG4667	esterase of the alpha-beta hydrolase superfamily
CF60_RS02860	COG0084	hydrolase, TatD family'
CF60_RS02865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF60_RS02870	COG1328	CTP reductase activity
CF60_RS02910	COG3726	membrane protein affecting hemolysin expression
CF60_RS02915	COG0560	Phosphoserine phosphatase
CF60_RS02920	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CF60_RS02925	COG3172	ATPase kinase involved in NAD metabolism
CF60_RS02925	COG1056	cytidyltransferase-related domain
CF60_RS02960	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS02970	COG0583	DNA-binding transcription factor activity
CF60_RS02975	COG0488	(ABC) transporter
CF60_RS02980	COG0741	lytic transglycosylase activity
CF60_RS03000	COG3708	Transcriptional regulator
CF60_RS03000	COG2207	Transcriptional regulator
CF60_RS03005	COG3045	CreA protein
CF60_RS03010	COG0745	RESPONSE REGULATOR receiver
CF60_RS03015	COG2205	protein histidine kinase activity
CF60_RS03020	COG4452	Inner membrane protein CreD
CF60_RS03025	COG0745	RESPONSE REGULATOR receiver
CF60_RS03035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CF60_RS03045	COG0527	aspartate kinase activity
CF60_RS03045	COG0460	homoserine dehydrogenase
CF60_RS03055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CF60_RS03075	COG1115	amino acid carrier protein
CF60_RS03085	COG0521	Mo-molybdopterin cofactor biosynthetic process
CF60_RS03090	COG1584	GPR1 FUN34 yaaH family protein
CF60_RS03095	COG4735	regulation of single-species biofilm formation
CF60_RS03125	COG3119	arylsulfatase activity
CF60_RS03140	COG0583	DNA-binding transcription factor activity
CF60_RS03150	COG3188	usher protein
CF60_RS03155	COG3121	Chaperone
CF60_RS03180	COG0196	riboflavin kinase activity
CF60_RS03195	COG1047	Peptidyl-prolyl cis-trans
CF60_RS03230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CF60_RS03285	COG0644	oxidoreductase
CF60_RS03290	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF60_RS03295	COG2271	Major facilitator Superfamily
CF60_RS03310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CF60_RS03335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF60_RS03340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CF60_RS03345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CF60_RS03350	COG1357	PFAM Pentapeptide repeats (8 copies)
CF60_RS03355	COG0564	pseudouridine synthase activity
CF60_RS03365	COG0417	DNA replication proofreading
CF60_RS03370	COG0235	Class ii aldolase
CF60_RS03385	COG4977	sequence-specific DNA binding
CF60_RS03390	COG0586	Pfam SNARE associated Golgi protein
CF60_RS03400	COG1178	ABC-type Fe3 transport system permease component
CF60_RS03405	COG4143	(ABC) transporter
CF60_RS03435	COG0473	3-isopropylmalate dehydrogenase activity
CF60_RS03450	COG0583	DNA-binding transcription factor activity
CF60_RS03455	COG0028	Belongs to the TPP enzyme family
CF60_RS03460	COG0440	acetolactate synthase activity
CF60_RS03470	COG1609	Transcriptional regulator
CF60_RS03485	COG3116	cell division
CF60_RS03490	COG0768	penicillin binding
CF60_RS03495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CF60_RS03500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CF60_RS03515	COG0772	Belongs to the SEDS family
CF60_RS03530	COG1181	Belongs to the D-alanine--D-alanine ligase family
CF60_RS03535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CF60_RS03540	COG0849	cell division
CF60_RS03545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CF60_RS03565	COG0494	nUDIX hydrolase
CF60_RS03585	COG0237	dephospho-CoA kinase activity
CF60_RS03595	COG1459	type II secretion system
CF60_RS03600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF60_RS03605	COG4969	Belongs to the N-Me-Phe pilin family
CF60_RS03615	COG0157	Belongs to the NadC ModD family
CF60_RS03620	COG3023	N-Acetylmuramoyl-L-alanine amidase
CF60_RS03625	COG3725	Membrane protein required for beta-lactamase induction
CF60_RS03630	COG1113	amino acid transport
CF60_RS03635	COG2186	Transcriptional regulator
CF60_RS03640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CF60_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF60_RS03650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF60_RS03655	COG3064	Membrane
CF60_RS03660	COG1049	propionate catabolic process, 2-methylcitrate cycle
CF60_RS03685	COG2132	Multicopper oxidase
CF60_RS03690	COG4993	Dehydrogenase
CF60_RS03695	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CF60_RS03700	COG0288	reversible hydration of carbon dioxide
CF60_RS03705	COG1131	(ABC) transporter
CF60_RS03710	COG0842	Transport permease protein
CF60_RS03715	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS03720	COG0726	polysaccharide deacetylase
CF60_RS03730	COG5464	transposase or invertase
CF60_RS03750	COG3539	Fimbrial protein
CF60_RS03755	COG3539	Fimbrial protein
CF60_RS03760	COG3539	Fimbrial protein
CF60_RS03765	COG3188	usher protein
CF60_RS03770	COG3121	Chaperone
CF60_RS03775	COG3539	Fimbrial protein
CF60_RS03780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CF60_RS03785	COG0617	tRNA 3'-terminal CCA addition
CF60_RS03790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CF60_RS03795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CF60_RS03805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CF60_RS03810	COG1643	Atp-dependent helicase
CF60_RS03815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CF60_RS03820	COG4774	siderophore transport
CF60_RS03825	COG1120	ATPase activity
CF60_RS03830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF60_RS03835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF60_RS03855	COG2860	membrane
CF60_RS03860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF60_RS03875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF60_RS03880	COG3835	regulator
CF60_RS03900	COG0024	Methionine aminopeptidase
CF60_RS03925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CF60_RS03930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CF60_RS03935	COG0575	Belongs to the CDS family
CF60_RS03940	COG0750	zinc metalloprotease
CF60_RS03950	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CF60_RS03955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CF60_RS03975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CF60_RS03980	COG0587	DNA-directed DNA polymerase activity
CF60_RS03990	COG1982	Orn Lys Arg decarboxylase major
CF60_RS03995	COG0346	lactoylglutathione lyase activity
CF60_RS04000	COG0037	tRNA processing
CF60_RS04005	COG4568	rho-dependent transcription termination
CF60_RS04015	COG4681	YaeQ
CF60_RS04020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CF60_RS04025	COG3015	lipoprotein NlpE involved in copper resistance
CF60_RS04030	COG0791	NLP P60 protein
CF60_RS04040	COG1720	tRNA m6t6A37 methyltransferase activity
CF60_RS04050	COG1464	Belongs to the NlpA lipoprotein family
CF60_RS04055	COG2011	ABC-type metal ion transport system permease component
CF60_RS04060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CF60_RS04065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CF60_RS04100	COG0656	L-ascorbic acid biosynthetic process
CF60_RS04105	COG0583	DNA-binding transcription factor activity
CF60_RS04115	COG2226	methyltransferase
CF60_RS04120	COG0741	lytic transglycosylase activity
CF60_RS04120	COG1388	LysM domain
CF60_RS04130	COG2226	methyltransferase
CF60_RS04140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF60_RS04160	COG4104	PAAR repeat-containing protein
CF60_RS04165	COG3157	Type VI secretion system effector, Hcp
CF60_RS04275	COG5433	transposase activity
CF60_RS04280	COG3328	transposase activity
CF60_RS04285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF60_RS04295	COG1960	acyl-CoA dehydrogenase activity
CF60_RS04305	COG0121	glutamine amidotransferase
CF60_RS04310	COG3034	peptidoglycan biosynthetic process
CF60_RS04315	COG0791	NLP P60 protein
CF60_RS04345	COG2161	toxin-antitoxin pair type II binding
CF60_RS04355	COG0454	-acetyltransferase
CF60_RS04360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CF60_RS04365	COG2195	Cleaves the N-terminal amino acid of tripeptides
CF60_RS04385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF60_RS04405	COG0582	viral genome integration into host DNA
CF60_RS04410	COG3423	Transcriptional regulator
CF60_RS04430	COG0583	DNA-binding transcription factor activity
CF60_RS04445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CF60_RS04450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF60_RS04455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF60_RS04465	COG3477	response to acidic pH
CF60_RS04470	COG0727	PFAM Uncharacterised protein family (UPF0153)
CF60_RS04520	COG1902	pentaerythritol trinitrate reductase activity
CF60_RS04525	COG1073	alpha beta
CF60_RS04530	COG0583	DNA-binding transcription factor activity
CF60_RS04540	COG0667	Aldo Keto reductase
CF60_RS04545	COG0656	L-ascorbic acid biosynthetic process
CF60_RS04550	COG1388	LysM domain
CF60_RS04555	COG2207	Transcriptional regulator
CF60_RS04555	COG3708	Transcriptional regulator
CF60_RS04560	COG0656	L-ascorbic acid biosynthetic process
CF60_RS04565	COG3059	membrane
CF60_RS04575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF60_RS04580	COG2207	Transcriptional regulator
CF60_RS04585	COG0247	lactate metabolic process
CF60_RS04590	COG1139	Iron-sulfur cluster binding protein
CF60_RS04595	COG1556	Lactate utilization protein
CF60_RS04625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CF60_RS04635	COG2771	luxR family
CF60_RS04635	COG2200	EAL domain
CF60_RS04640	COG0583	DNA-binding transcription factor activity
CF60_RS04650	COG0666	response to abiotic stimulus
CF60_RS04660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF60_RS04665	COG1304	FMN binding
CF60_RS04670	COG0549	Belongs to the carbamate kinase family
CF60_RS04675	COG0402	S-adenosylhomocysteine deaminase activity
CF60_RS04685	COG1879	ABC-type sugar transport system periplasmic component
CF60_RS04690	COG1129	ABC transporter
CF60_RS04695	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF60_RS04705	COG1064	alcohol dehydrogenase
CF60_RS04720	COG1280	lysine exporter protein (LysE YggA)
CF60_RS04730	COG3829	transcription factor binding
CF60_RS04735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CF60_RS04740	COG0372	Belongs to the citrate synthase family
CF60_RS04745	COG2079	MmgE PrpD family protein
CF60_RS04750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CF60_RS04755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CF60_RS04760	COG0402	S-adenosylhomocysteine deaminase activity
CF60_RS04765	COG0583	DNA-binding transcription factor activity
CF60_RS04770	COG0288	reversible hydration of carbon dioxide
CF60_RS04780	COG2807	transmembrane transport
CF60_RS04785	COG0110	maltose O-acetyltransferase activity
CF60_RS04790	COG2223	nitrite transmembrane transporter activity
CF60_RS04800	COG1609	Transcriptional regulator
CF60_RS04805	COG1414	Transcriptional regulator
CF60_RS04840	COG2814	Major facilitator Superfamily
CF60_RS04845	COG3122	Protein conserved in bacteria
CF60_RS04875	COG1215	transferase activity, transferring glycosyl groups
CF60_RS04880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CF60_RS04885	COG4521	taurine ABC transporter
CF60_RS04890	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CF60_RS04895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CF60_RS04900	COG2175	clavaminate synthase activity
CF60_RS04905	COG0113	porphobilinogen synthase activity
CF60_RS04910	COG3468	outer membrane autotransporter barrel domain protein
CF60_RS04915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF60_RS04920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF60_RS04930	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CF60_RS04950	COG1181	Belongs to the D-alanine--D-alanine ligase family
CF60_RS04965	COG1785	Belongs to the alkaline phosphatase family
CF60_RS04975	COG3706	GGDEF domain
CF60_RS05000	COG4126	flavin adenine dinucleotide binding
CF60_RS05020	COG1940	carbohydrate kinase activity
CF60_RS05030	COG0419	ATPase involved in DNA repair
CF60_RS05035	COG0420	3'-5' exonuclease activity
CF60_RS05040	COG0745	RESPONSE REGULATOR receiver
CF60_RS05045	COG5002	protein histidine kinase activity
CF60_RS05050	COG1114	Component of the transport system for branched-chain amino acids
CF60_RS05055	COG1113	amino acid transport
CF60_RS05060	COG0366	Alpha amylase catalytic
CF60_RS05085	COG1862	Preprotein translocase
CF60_RS05090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF60_RS05095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CF60_RS05100	COG1403	HNH endonuclease
CF60_RS05110	COG3248	Nucleoside-binding outer membrane protein
CF60_RS05115	COG4238	major outer membrane lipoprotein
CF60_RS05130	COG0675	Transposase, IS605 OrfB family
CF60_RS05135	COG4238	major outer membrane lipoprotein
CF60_RS05145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF60_RS05145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CF60_RS05160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CF60_RS05165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CF60_RS05175	COG0667	Aldo Keto reductase
CF60_RS05185	COG0142	geranyltranstransferase activity
CF60_RS05200	COG0693	protein deglycase activity
CF60_RS05205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CF60_RS05215	COG2814	Major facilitator Superfamily
CF60_RS05225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CF60_RS05230	COG1845	cytochrome c oxidase, subunit III
CF60_RS05235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CF60_RS05240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CF60_RS05245	COG2223	nitrite transmembrane transporter activity
CF60_RS05250	COG3056	Lipoprotein
CF60_RS05255	COG0271	Belongs to the BolA IbaG family
CF60_RS05280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CF60_RS05285	COG0776	regulation of translation
CF60_RS05290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF60_RS05295	COG1555	photosystem II stabilization
CF60_RS05300	COG0824	Thioesterase
CF60_RS05310	COG4533	DNA binding
CF60_RS05320	COG1522	sequence-specific DNA binding
CF60_RS05325	COG1132	(ABC) transporter
CF60_RS05330	COG1132	(ABC) transporter
CF60_RS05335	COG0347	Belongs to the P(II) protein family
CF60_RS05340	COG0004	ammonium transporteR
CF60_RS05345	COG1946	Acyl-CoA thioesterase
CF60_RS05350	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CF60_RS05355	COG3695	enzyme binding
CF60_RS05360	COG5507	3-demethylubiquinone-9 3-methyltransferase
CF60_RS05365	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CF60_RS05375	COG0110	maltose O-acetyltransferase activity
CF60_RS05390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF60_RS05395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF60_RS05400	COG1309	transcriptional regulator
CF60_RS05405	COG3264	Mechanosensitive ion channel
CF60_RS05405	COG1196	nuclear chromosome segregation
CF60_RS05415	COG3923	Primosomal replication protein n
CF60_RS05420	COG2832	Protein of unknown function (DUF454)
CF60_RS05430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CF60_RS05465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF60_RS05470	COG4651	solute:proton antiporter activity
CF60_RS05470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CF60_RS05475	COG2223	nitrite transmembrane transporter activity
CF60_RS05485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CF60_RS05490	COG3735	TraB family
CF60_RS05495	COG2217	Heavy metal translocating P-type atpase
CF60_RS05505	COG0531	amino acid
CF60_RS05535	COG0789	Transcriptional regulator
CF60_RS05560	COG1585	Membrane protein implicated in regulation of membrane protease activity
CF60_RS05565	COG0330	HflC and HflK could
CF60_RS05570	COG4619	ABC transporter
CF60_RS05575	COG0390	transport system, permease component
CF60_RS05585	COG0300	oxidoreductase activity
CF60_RS05590	COG2755	lipolytic protein G-D-S-L family
CF60_RS05595	COG4181	ATPase activity
CF60_RS05600	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CF60_RS05605	COG3209	COG3209 Rhs family protein
CF60_RS05615	COG2801	Transposase and inactivated derivatives
CF60_RS05625	COG0583	DNA-binding transcription factor activity
CF60_RS05635	COG1414	Transcriptional regulator
CF60_RS05640	COG3960	tartronate-semialdehyde synthase activity
CF60_RS05645	COG3622	Belongs to the hyi family
CF60_RS05650	COG2084	Dehydrogenase
CF60_RS05655	COG1953	Uracil, thiamine, allantoin
CF60_RS05665	COG2233	PERMEase
CF60_RS05670	COG1929	Belongs to the glycerate kinase type-1 family
CF60_RS05675	COG3257	ureidoglycine aminohydrolase activity
CF60_RS05680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CF60_RS05685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CF60_RS05690	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF60_RS05695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF60_RS05705	COG0549	Belongs to the carbamate kinase family
CF60_RS05710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CF60_RS05715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CF60_RS05725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CF60_RS05735	COG1988	membrane-bound metal-dependent
CF60_RS05740	COG2501	S4 domain
CF60_RS05750	COG3539	Fimbrial protein
CF60_RS05755	COG3121	Chaperone
CF60_RS05760	COG3188	usher protein
CF60_RS05765	COG3539	Fimbrial protein
CF60_RS05770	COG3539	Fimbrial protein
CF60_RS05775	COG2197	response regulator
CF60_RS05785	COG0582	viral genome integration into host DNA
CF60_RS05870	COG2076	Multidrug Resistance protein
CF60_RS05880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF60_RS05885	COG1881	PFAM PEBP family protein
CF60_RS05890	COG2207	Transcriptional regulator
CF60_RS05935	COG3772	lysozyme
CF60_RS05955	COG5562	phage envelope protein
CF60_RS05975	COG4220	transposase activity
CF60_RS05995	COG1030	water channel activity
CF60_RS06045	COG1196	nuclear chromosome segregation
CF60_RS06105	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF60_RS06130	COG2207	Transcriptional regulator
CF60_RS06135	COG4571	Outer membrane protease
CF60_RS06145	COG2207	Transcriptional regulator
CF60_RS06155	COG4783	chaperone-mediated protein folding
CF60_RS06160	COG1215	transferase activity, transferring glycosyl groups
CF60_RS06165	COG5433	transposase activity
CF60_RS06175	COG4104	PAAR repeat-containing protein
CF60_RS06175	COG3209	COG3209 Rhs family protein
CF60_RS06225	COG5002	protein histidine kinase activity
CF60_RS06230	COG0745	RESPONSE REGULATOR receiver
CF60_RS06235	COG1538	Outer membrane efflux protein
CF60_RS06240	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF60_RS06245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF60_RS06250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF60_RS06255	COG1113	amino acid transport
CF60_RS06260	COG0668	transmembrane transport
CF60_RS06265	COG0778	Nitroreductase
CF60_RS06270	COG2315	Protein conserved in bacteria
CF60_RS06290	COG2963	transposase activity
CF60_RS06295	COG2801	Transposase and inactivated derivatives
CF60_RS06305	COG2977	Belongs to the P-Pant transferase superfamily
CF60_RS06315	COG4771	TonB-dependent receptor
CF60_RS06320	COG2382	esterase
CF60_RS06325	COG3251	PFAM MbtH domain protein
CF60_RS06330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CF60_RS06330	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CF60_RS06335	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF60_RS06340	COG1120	ATPase activity
CF60_RS06345	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF60_RS06350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF60_RS06360	COG4592	Periplasmic binding protein
CF60_RS06365	COG1169	isochorismate synthase
CF60_RS06370	COG1021	2,3-dihydroxybenzoate-AMP ligase
CF60_RS06375	COG3433	isochorismatase activity
CF60_RS06375	COG1535	isochorismatase
CF60_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS06390	COG1966	Carbon starvation protein
CF60_RS06395	COG2879	small protein
CF60_RS06400	COG0371	Dehydrogenase
CF60_RS06405	COG0436	Aminotransferase
CF60_RS06410	COG1475	DNA binding
CF60_RS06415	COG3969	phosphoadenosine phosphosulfate
CF60_RS06420	COG0583	DNA-binding transcription factor activity
CF60_RS06425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF60_RS06430	COG0450	alkyl hydroperoxide reductase
CF60_RS06435	COG3634	alkyl hydroperoxide reductase activity
CF60_RS06440	COG0589	response to stress
CF60_RS06445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF60_RS06450	COG3719	Belongs to the RNase T2 family
CF60_RS06455	COG0471	metal ion transport
CF60_RS06470	COG3051	citrate lyase alpha subunit
CF60_RS06475	COG2301	Belongs to the HpcH HpaI aldolase family
CF60_RS06485	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CF60_RS06490	COG3290	protein histidine kinase activity
CF60_RS06495	COG4565	transcriptional regulatory protein
CF60_RS06500	COG3069	C4-dicarboxylate transmembrane transporter activity
CF60_RS06520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF60_RS06525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF60_RS06535	COG0583	DNA-binding transcription factor activity
CF60_RS06555	COG1686	Belongs to the peptidase S11 family
CF60_RS06560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CF60_RS06565	COG0772	Belongs to the SEDS family
CF60_RS06570	COG0768	penicillin binding
CF60_RS06580	COG0799	negative regulation of ribosome biogenesis
CF60_RS06585	COG0406	alpha-ribazole phosphatase activity
CF60_RS06595	COG1466	dna polymerase III delta subunit
CF60_RS06610	COG2888	peptidyl-tyrosine sulfation
CF60_RS06620	COG1126	abc transporter atp-binding protein
CF60_RS06625	COG0765	amino acid transport
CF60_RS06630	COG0765	amino acid transport
CF60_RS06635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF60_RS06640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CF60_RS06645	COG4535	Mg2 and Co2 transporter CorC
CF60_RS06655	COG1702	phosphate starvation-inducible protein PhoH
CF60_RS06665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF60_RS06705	COG0367	asparagine synthase
CF60_RS06710	COG0647	UMP catabolic process
CF60_RS06715	COG1940	carbohydrate kinase activity
CF60_RS06715	COG1846	Transcriptional regulator
CF60_RS06720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF60_RS06730	COG1263	PTS System
CF60_RS06730	COG2190	(PTS) system
CF60_RS06730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS06750	COG0735	belongs to the Fur family
CF60_RS06765	COG0716	FMN binding
CF60_RS06775	COG0596	Alpha beta hydrolase
CF60_RS06780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CF60_RS06785	COG0033	Phosphoglucomutase
CF60_RS06800	COG0745	RESPONSE REGULATOR receiver
CF60_RS06835	COG3209	COG3209 Rhs family protein
CF60_RS06845	COG3272	Protein of unknown function (DUF1722)
CF60_RS06850	COG0415	Belongs to the DNA photolyase family
CF60_RS06860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CF60_RS06865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CF60_RS06870	COG1984	allophanate hydrolase subunit 2
CF60_RS06885	COG3180	Ammonia monooxygenase
CF60_RS06890	COG3539	Fimbrial protein
CF60_RS06895	COG3121	Chaperone
CF60_RS06900	COG3188	usher protein
CF60_RS06905	COG3539	Fimbrial protein
CF60_RS06910	COG0372	Belongs to the citrate synthase family
CF60_RS06920	COG2009	succinate dehydrogenase
CF60_RS06925	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CF60_RS06930	COG1053	succinate dehydrogenase
CF60_RS06935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CF60_RS06945	COG0567	Dehydrogenase, E1 component
CF60_RS06950	COG1053	succinate dehydrogenase
CF60_RS06960	COG0567	Dehydrogenase, E1 component
CF60_RS06965	COG0508	dehydrogenase complex catalyzes the overall conversion of
CF60_RS06975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CF60_RS06985	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CF60_RS07005	COG4865	methylaspartate mutase activity
CF60_RS07015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF60_RS07035	COG1271	oxidase subunit
CF60_RS07040	COG1294	oxidase, subunit
CF60_RS07045	COG4890	Cyd operon protein YbgT
CF60_RS07050	COG3790	cyd operon protein YbgE
CF60_RS07055	COG0824	Thioesterase
CF60_RS07060	COG0811	peptide transport
CF60_RS07065	COG0848	biopolymer transport protein
CF60_RS07070	COG3064	Membrane
CF60_RS07080	COG2885	chlorophyll binding
CF60_RS07085	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CF60_RS07130	COG3201	nicotinamide mononucleotide transporter
CF60_RS07135	COG1230	cation diffusion facilitator family transporter
CF60_RS07150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF60_RS07160	COG2017	converts alpha-aldose to the beta-anomer
CF60_RS07170	COG1085	galactose-1-phosphate uridylyltransferase
CF60_RS07175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CF60_RS07180	COG1119	ATPase activity
CF60_RS07190	COG2005	Transcriptional regulator
CF60_RS07190	COG3585	molybdate ion transport
CF60_RS07200	COG0725	ABC transporter, periplasmic molybdate-binding protein
CF60_RS07205	COG4149	molybdate abc transporter
CF60_RS07210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CF60_RS07215	COG0561	phosphatase activity
CF60_RS07230	COG2828	Protein conserved in bacteria
CF60_RS07235	COG0471	metal ion transport
CF60_RS07240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CF60_RS07245	COG4677	pectinesterase activity
CF60_RS07250	COG1881	PFAM PEBP family protein
CF60_RS07255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CF60_RS07270	COG2226	methyltransferase
CF60_RS07275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CF60_RS07285	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CF60_RS07300	COG0521	Mo-molybdopterin cofactor biosynthetic process
CF60_RS07310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CF60_RS07315	COG0314	molybdopterin synthase activity
CF60_RS07320	COG0670	Belongs to the BI1 family
CF60_RS07325	COG0670	Belongs to the BI1 family
CF60_RS07330	COG0392	lysyltransferase activity
CF60_RS07335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF60_RS07340	COG3568	Endonuclease Exonuclease Phosphatase
CF60_RS07350	COG0842	Transport permease protein
CF60_RS07355	COG0842	Transport permease protein
CF60_RS07360	COG1131	(ABC) transporter
CF60_RS07370	COG1309	transcriptional regulator
CF60_RS07375	COG0513	Belongs to the DEAD box helicase family
CF60_RS07390	COG1199	ATP-dependent helicase activity
CF60_RS07395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CF60_RS07400	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CF60_RS07410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CF60_RS07435	COG0668	transmembrane transport
CF60_RS07445	COG1126	abc transporter atp-binding protein
CF60_RS07450	COG0765	amino acid transport
CF60_RS07455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF60_RS07470	COG5006	permease, DMT superfamily
CF60_RS07475	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CF60_RS07480	COG2194	sulfuric ester hydrolase activity
CF60_RS07490	COG1321	iron dependent repressor
CF60_RS07495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CF60_RS07500	COG1376	ErfK ybiS ycfS ynhG family protein
CF60_RS07505	COG0488	(ABC) transporter
CF60_RS07515	COG2271	Major facilitator Superfamily
CF60_RS07535	COG0561	phosphatase activity
CF60_RS07540	COG1882	Formate acetyltransferase
CF60_RS07545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF60_RS07550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF60_RS07555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CF60_RS07560	COG0303	'Molybdopterin
CF60_RS07565	COG1446	asparaginase
CF60_RS07575	COG0747	negative chemotaxis
CF60_RS07590	COG2200	EAL domain
CF60_RS07595	COG2199	diguanylate cyclase activity
CF60_RS07610	COG2133	pyrroloquinoline quinone binding
CF60_RS07615	COG0625	glutathione transferase activity
CF60_RS07620	COG1686	Belongs to the peptidase S11 family
CF60_RS07625	COG1349	DNA-binding transcription factor activity
CF60_RS07630	COG0671	phosphoesterase, PA-phosphatase related
CF60_RS07635	COG2814	Major facilitator Superfamily
CF60_RS07645	COG0561	phosphatase activity
CF60_RS07650	COG0738	Major facilitator superfamily
CF60_RS07655	COG3226	Transcriptional regulator
CF60_RS07670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF60_RS07680	COG0778	Nitroreductase
CF60_RS07700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF60_RS07705	COG3842	ATPase activity
CF60_RS07710	COG1176	ABC-type spermidine putrescine transport system, permease component I
CF60_RS07715	COG1177	transmembrane transport
CF60_RS07735	COG4160	amino acid transport
CF60_RS07740	COG4215	(ABC) transporter
CF60_RS07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF60_RS07750	COG1126	abc transporter atp-binding protein
CF60_RS07765	COG0702	epimerase
CF60_RS07785	COG0702	epimerase
CF60_RS07800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF60_RS07810	COG2431	L-lysine efflux transmembrane transporter activity
CF60_RS07815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CF60_RS07825	COG3593	DNA synthesis involved in DNA repair
CF60_RS07835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF60_RS07840	COG0577	efflux transmembrane transporter activity
CF60_RS07840	COG1136	(ABC) transporter
CF60_RS07845	COG1278	Cold shock
CF60_RS07855	COG0542	response to heat
CF60_RS07875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CF60_RS07880	COG4988	ABC transporter
CF60_RS07885	COG0492	ferredoxin-NADP+ reductase activity
CF60_RS07890	COG1522	sequence-specific DNA binding
CF60_RS07895	COG1674	ftsk spoiiie
CF60_RS07895	COG1178	ABC-type Fe3 transport system permease component
CF60_RS07905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CF60_RS07915	COG0243	molybdopterin cofactor binding
CF60_RS07920	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS07925	COG3302	dmso reductase anchor subunit
CF60_RS07930	COG1335	isochorismatase
CF60_RS07940	COG0531	amino acid
CF60_RS07945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CF60_RS07950	COG1882	Formate acetyltransferase
CF60_RS07955	COG2116	formate transmembrane transporter activity
CF60_RS07960	COG1944	ATP diphosphatase activity
CF60_RS07965	COG2323	membrane
CF60_RS07995	COG0501	Belongs to the peptidase M48B family
CF60_RS08005	COG0539	negative regulation of cytoplasmic translation
CF60_RS08025	COG0539	negative regulation of cytoplasmic translation
CF60_RS08050	COG3214	Protein conserved in bacteria
CF60_RS08065	COG3173	Aminoglycoside phosphotransferase
CF60_RS08070	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CF60_RS08075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CF60_RS08085	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CF60_RS08095	COG2989	Protein conserved in bacteria
CF60_RS08100	COG3108	Peptidase M15
CF60_RS08105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CF60_RS08110	COG1448	Aminotransferase
CF60_RS08150	COG0308	aminopeptidase N
CF60_RS08155	COG2801	Transposase and inactivated derivatives
CF60_RS08170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CF60_RS08175	COG0431	NADPH-dependent FMN reductase
CF60_RS08190	COG3217	Mosc domain protein beta barrel domain protein
CF60_RS08190	COG0633	Ferredoxin
CF60_RS08200	COG0488	(ABC) transporter
CF60_RS08205	COG2995	paraquat-inducible protein a
CF60_RS08210	COG3008	intermembrane lipid transfer
CF60_RS08210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CF60_RS08215	COG3009	Protein conserved in bacteria
CF60_RS08220	COG3130	regulation of translation
CF60_RS08230	COG1067	ATP-dependent peptidase activity
CF60_RS08255	COG3070	regulator of competence-specific genes
CF60_RS08260	COG1289	transmembrane transporter activity
CF60_RS08265	COG3304	Inner membrane component domain
CF60_RS08270	COG0210	DNA helicase
CF60_RS08290	COG1832	CoA-binding protein
CF60_RS08305	COG1254	Belongs to the acylphosphatase family
CF60_RS08310	COG2920	part of a sulfur-relay system
CF60_RS08315	COG0670	Belongs to the BI1 family
CF60_RS08325	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CF60_RS08330	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CF60_RS08335	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CF60_RS08340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF60_RS08345	COG1999	signal sequence binding
CF60_RS08350	COG1773	rubredoxin
CF60_RS08355	COG1271	oxidase subunit
CF60_RS08360	COG1294	oxidase, subunit
CF60_RS08375	COG1278	Cold shock
CF60_RS08380	COG1278	Cold shock
CF60_RS08395	COG2205	protein histidine kinase activity
CF60_RS08395	COG2198	Histidine kinase
CF60_RS08395	COG0784	Response regulator, receiver
CF60_RS08400	COG1879	ABC-type sugar transport system periplasmic component
CF60_RS08405	COG0745	RESPONSE REGULATOR receiver
CF60_RS08410	COG3005	denitrification pathway
CF60_RS08415	COG0243	molybdopterin cofactor binding
CF60_RS08420	COG3381	protein complex oligomerization
CF60_RS08460	COG3729	General stress protein
CF60_RS08465	COG2233	PERMEase
CF60_RS08500	COG1309	transcriptional regulator
CF60_RS08515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF60_RS08540	COG1702	phosphate starvation-inducible protein PhoH
CF60_RS08560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CF60_RS08570	COG3381	protein complex oligomerization
CF60_RS08580	COG1462	curli production assembly transport component CsgG
CF60_RS08595	COG2197	response regulator
CF60_RS08625	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF60_RS08630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF60_RS08655	COG2943	transferase activity, transferring hexosyl groups
CF60_RS08660	COG5645	(Lipo)protein
CF60_RS08680	COG1560	Kdo2-lipid A biosynthetic process
CF60_RS08690	COG2353	YceI-like domain
CF60_RS08695	COG3038	cytochrome b561
CF60_RS08725	COG2999	glutathione oxidoreductase activity
CF60_RS08735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF60_RS08745	COG0673	inositol 2-dehydrogenase activity
CF60_RS08750	COG0728	peptidoglycan biosynthetic process
CF60_RS08755	COG3418	PFAM FlgN family protein
CF60_RS08760	COG2747	anti-sigma28 factor FlgM
CF60_RS08765	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CF60_RS08770	COG1815	bacterial-type flagellum-dependent cell motility
CF60_RS08775	COG1558	bacterial-type flagellum-dependent cell motility
CF60_RS08780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CF60_RS08785	COG1749	Flagellar hook protein flgE
CF60_RS08790	COG4787	bacterial-type flagellum-dependent cell motility
CF60_RS08795	COG4786	Flagellar basal body rod
CF60_RS08810	COG3951	Flagellar rod assembly protein muramidase FlgJ
CF60_RS08810	COG1705	Flagellar rod assembly protein muramidase FlgJ
CF60_RS08815	COG1256	bacterial-type flagellum assembly
CF60_RS08820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CF60_RS08825	COG1530	ribonuclease E activity
CF60_RS08835	COG0564	pseudouridine synthase activity
CF60_RS08840	COG0424	maF-like protein
CF60_RS08845	COG1399	metal-binding, possibly nucleic acid-binding protein
CF60_RS08865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CF60_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS08880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF60_RS08885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CF60_RS08890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CF60_RS08900	COG0470	DNA polymerase III
CF60_RS08905	COG0084	hydrolase, TatD family'
CF60_RS08910	COG1263	PTS System
CF60_RS08910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS08915	COG4773	Receptor
CF60_RS08920	COG0537	adenosine 5'-monophosphoramidase activity
CF60_RS08925	COG5633	Lipoprotein
CF60_RS08930	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CF60_RS08950	COG1252	NADH dehydrogenase
CF60_RS08955	COG3134	Outer membrane lipoprotein
CF60_RS08960	COG1309	transcriptional regulator
CF60_RS08970	COG1388	LysM domain
CF60_RS08970	COG1376	ErfK ybiS ycfS ynhG family protein
CF60_RS08980	COG4763	Acyl-transferase
CF60_RS08985	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF60_RS08995	COG4591	ABC-type transport system involved in lipoprotein release permease component
CF60_RS09010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CF60_RS09020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF60_RS09025	COG1177	transmembrane transport
CF60_RS09035	COG3842	ATPase activity
CF60_RS09050	COG2850	peptidyl-arginine hydroxylation
CF60_RS09055	COG2205	protein histidine kinase activity
CF60_RS09065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CF60_RS09085	COG1187	pseudouridine synthase activity
CF60_RS09090	COG0538	isocitrate dehydrogenase activity
CF60_RS09105	COG5562	phage envelope protein
CF60_RS09110	COG0789	Transcriptional regulator
CF60_RS09115	COG2200	EAL domain
CF60_RS09125	COG2200	EAL domain
CF60_RS09160	COG3468	outer membrane autotransporter barrel domain protein
CF60_RS09170	COG2894	cell division
CF60_RS09200	COG0179	Fumarylacetoacetate (FAA) hydrolase
CF60_RS09215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CF60_RS09220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CF60_RS09225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CF60_RS09245	COG2719	SpoVR family
CF60_RS09255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CF60_RS09270	COG1619	proteins homologs of microcin C7 resistance protein MccF
CF60_RS09280	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CF60_RS09295	COG0157	Belongs to the NadC ModD family
CF60_RS09300	COG0500	methyltransferase
CF60_RS09305	COG1120	ATPase activity
CF60_RS09310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF60_RS09315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CF60_RS09325	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CF60_RS09325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS09325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF60_RS09330	COG1461	Dihydroxyacetone kinase
CF60_RS09335	COG2376	Dihydroxyacetone kinase
CF60_RS09340	COG3284	Transcriptional regulator
CF60_RS09345	COG3468	outer membrane autotransporter barrel domain protein
CF60_RS09355	COG0012	GTP binding
CF60_RS09360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CF60_RS09385	COG2890	protein-(glutamine-N5) methyltransferase activity
CF60_RS09390	COG3094	Invasion gene expression up-regulator, SirB
CF60_RS09395	COG2912	Transglutaminase-like superfamily
CF60_RS09415	COG0387	Pfam Sodium calcium exchanger
CF60_RS09420	COG4572	Cation transport regulator
CF60_RS09425	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CF60_RS09430	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CF60_RS09435	COG4932	domain protein
CF60_RS09440	COG2197	response regulator
CF60_RS09445	COG3850	Histidine kinase
CF60_RS09455	COG2223	nitrite transmembrane transporter activity
CF60_RS09460	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CF60_RS09465	COG1140	nitrate reductase beta subunit
CF60_RS09470	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CF60_RS09475	COG2181	nitrate reductase activity
CF60_RS09490	COG0788	formyltetrahydrofolate deformylase activity
CF60_RS09500	COG1752	Esterase of the alpha-beta hydrolase superfamily
CF60_RS09505	COG0745	RESPONSE REGULATOR receiver
CF60_RS09510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CF60_RS09520	COG1435	thymidine kinase activity
CF60_RS09525	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS09525	COG1454	alcohol dehydrogenase
CF60_RS09530	COG2095	MarC family integral membrane protein
CF60_RS09535	COG4166	transmembrane transport
CF60_RS09545	COG0444	Belongs to the ABC transporter superfamily
CF60_RS09550	COG4608	Belongs to the ABC transporter superfamily
CF60_RS09575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CF60_RS09580	COG2350	Protein conserved in bacteria
CF60_RS09585	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CF60_RS09590	COG1607	acyl-coa hydrolase
CF60_RS09605	COG3047	cAMP biosynthetic process
CF60_RS09610	COG3685	Protein conserved in bacteria
CF60_RS09620	COG3729	General stress protein
CF60_RS09625	COG0159	tryptophan synthase activity
CF60_RS09635	COG0135	phosphoribosylanthranilate isomerase activity
CF60_RS09635	COG0134	indole-3-glycerol-phosphate synthase activity
CF60_RS09640	COG0512	Glutamine amidotransferase of anthranilate synthase
CF60_RS09640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CF60_RS09645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CF60_RS09650	COG0613	PHP domain protein
CF60_RS09655	COG0009	L-threonylcarbamoyladenylate synthase
CF60_RS09665	COG1187	pseudouridine synthase activity
CF60_RS09680	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CF60_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS09695	COG0616	signal peptide processing
CF60_RS09710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CF60_RS09715	COG0583	DNA-binding transcription factor activity
CF60_RS09740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CF60_RS09750	COG0671	phosphoesterase, PA-phosphatase related
CF60_RS09755	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CF60_RS09760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CF60_RS09770	COG0023	Translation Initiation Factor
CF60_RS09780	COG1349	DNA-binding transcription factor activity
CF60_RS09790	COG5001	Diguanylate cyclase
CF60_RS09805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF60_RS09805	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF60_RS09810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CF60_RS09820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF60_RS09825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF60_RS09835	COG2814	Major facilitator Superfamily
CF60_RS09840	COG4172	Belongs to the ABC transporter superfamily
CF60_RS09845	COG4172	Belongs to the ABC transporter superfamily
CF60_RS09850	COG4171	peptide transport system, permease
CF60_RS09855	COG4168	peptide transport system, permease
CF60_RS09860	COG4166	transmembrane transport
CF60_RS09865	COG4166	transmembrane transport
CF60_RS09890	COG0531	amino acid
CF60_RS09895	COG0174	glutamine synthetase
CF60_RS09900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CF60_RS09905	COG1396	sequence-specific DNA binding
CF60_RS09905	COG1917	Cupin 2, conserved barrel domain protein
CF60_RS09910	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS09920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CF60_RS09925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CF60_RS09930	COG1842	Phage shock protein A
CF60_RS09940	COG1983	PspC domain protein
CF60_RS09950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF60_RS09955	COG3106	COG3106 Predicted ATPase
CF60_RS09965	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CF60_RS09970	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CF60_RS09975	COG4948	Mandelate Racemase Muconate Lactonizing
CF60_RS09980	COG2866	Carboxypeptidase
CF60_RS09985	COG0702	epimerase
CF60_RS09990	COG1073	alpha beta
CF60_RS09995	COG0583	DNA-binding transcription factor activity
CF60_RS10005	COG4166	transmembrane transport
CF60_RS10010	COG0668	transmembrane transport
CF60_RS10015	COG3182	Iron-regulated membrane protein
CF60_RS10020	COG0589	response to stress
CF60_RS10025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF60_RS10030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CF60_RS10035	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CF60_RS10045	COG1473	amidohydrolase
CF60_RS10050	COG1473	amidohydrolase
CF60_RS10055	COG0583	DNA-binding transcription factor activity
CF60_RS10080	COG2840	Smr protein MutS2
CF60_RS10085	COG3706	GGDEF domain
CF60_RS10100	COG0513	Belongs to the DEAD box helicase family
CF60_RS10110	COG0582	viral genome integration into host DNA
CF60_RS10135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF60_RS10165	COG4197	protein conserved in bacteria, prophage-related
CF60_RS10175	COG3756	Protein conserved in bacteria
CF60_RS10180	COG1484	DNA-dependent DNA replication
CF60_RS10185	COG1846	Transcriptional regulator
CF60_RS10235	COG3064	Membrane
CF60_RS10250	COG3772	lysozyme
CF60_RS10260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CF60_RS10265	COG1475	DNA binding
CF60_RS10440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CF60_RS10510	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CF60_RS10620	COG5301	cellulose 1,4-beta-cellobiosidase activity
CF60_RS10640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF60_RS10650	COG0589	response to stress
CF60_RS10655	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF60_RS10660	COG0674	pyruvate-flavodoxin oxidoreductase activity
CF60_RS10660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CF60_RS10660	COG1013	pyruvate-flavodoxin oxidoreductase activity
CF60_RS10660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF60_RS10665	COG3042	response to heat
CF60_RS10670	COG3187	Heat shock protein
CF60_RS10675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CF60_RS10680	COG2911	Protein conserved in bacteria
CF60_RS10690	COG3784	Protein of unknown function (DUF1318)
CF60_RS10695	COG2207	Transcriptional regulator
CF60_RS10700	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS10705	COG3733	amine oxidase
CF60_RS10710	COG2030	dehydratase
CF60_RS10710	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS10715	COG3396	Phenylacetate-CoA oxygenase
CF60_RS10720	COG3460	Phenylacetate-CoA oxygenase
CF60_RS10725	COG3396	Phenylacetate-CoA oxygenase
CF60_RS10730	COG2151	metal-sulfur cluster biosynthetic enzyme
CF60_RS10735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF60_RS10740	COG1024	Enoyl-CoA hydratase
CF60_RS10745	COG1024	Enoyl-CoA hydratase
CF60_RS10750	COG1250	3-hydroxyacyl-CoA dehydrogenase
CF60_RS10755	COG2050	protein possibly involved in aromatic compounds catabolism
CF60_RS10760	COG0183	Belongs to the thiolase family
CF60_RS10765	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CF60_RS10770	COG3327	negative regulation of DNA-templated transcription, initiation
CF60_RS10775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF60_RS10785	COG0667	Aldo Keto reductase
CF60_RS10795	COG1643	Atp-dependent helicase
CF60_RS10800	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CF60_RS10805	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS10810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CF60_RS10815	COG3038	cytochrome b561
CF60_RS10830	COG2801	Transposase and inactivated derivatives
CF60_RS10835	COG2963	transposase activity
CF60_RS10840	COG0840	transmembrane signaling receptor activity
CF60_RS10845	COG0583	DNA-binding transcription factor activity
CF60_RS10850	COG5383	Protein conserved in bacteria
CF60_RS10865	COG2841	Protein conserved in bacteria
CF60_RS10870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF60_RS10875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF60_RS10880	COG1275	C4-dicarboxylate transporter malic acid transport protein
CF60_RS10885	COG0500	methyltransferase
CF60_RS10895	COG3135	benzoate transporter
CF60_RS10900	COG1396	sequence-specific DNA binding
CF60_RS10905	COG0826	peptidase U32
CF60_RS10915	COG1724	mRNA binding
CF60_RS10920	COG1598	PFAM Uncharacterised protein family UPF0150
CF60_RS10925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF60_RS10930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CF60_RS10935	COG3842	ATPase activity
CF60_RS10940	COG1176	ABC-type spermidine putrescine transport system, permease component I
CF60_RS10945	COG1177	transmembrane transport
CF60_RS10970	COG3238	Protein conserved in bacteria
CF60_RS10975	COG1247	-acetyltransferase
CF60_RS10980	COG2130	NADP-dependent
CF60_RS10985	COG1802	Transcriptional regulator
CF60_RS10990	COG4772	TonB-dependent receptor
CF60_RS10995	COG3391	amine dehydrogenase activity
CF60_RS11000	COG1113	amino acid transport
CF60_RS11035	COG5433	transposase activity
CF60_RS11040	COG5001	Diguanylate cyclase
CF60_RS11040	COG4251	negative regulation of phosphorylation
CF60_RS11040	COG2203	Gaf domain
CF60_RS11040	COG3706	GGDEF domain
CF60_RS11045	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CF60_RS11055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CF60_RS11060	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CF60_RS11065	COG0384	phenazine biosynthesis protein PhzF
CF60_RS11070	COG2181	nitrate reductase activity
CF60_RS11075	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CF60_RS11080	COG1140	nitrate reductase beta subunit
CF60_RS11085	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CF60_RS11090	COG2223	nitrite transmembrane transporter activity
CF60_RS11095	COG4886	Leucine-rich repeat (LRR) protein
CF60_RS11100	COG4886	Leucine-rich repeat (LRR) protein
CF60_RS11110	COG0697	spore germination
CF60_RS11115	COG0243	molybdopterin cofactor binding
CF60_RS11115	COG3383	formate dehydrogenase (NAD+) activity
CF60_RS11120	COG0243	molybdopterin cofactor binding
CF60_RS11120	COG3383	formate dehydrogenase (NAD+) activity
CF60_RS11125	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS11130	COG2864	formate dehydrogenase
CF60_RS11145	COG3093	addiction module antidote protein HigA
CF60_RS11150	COG1064	alcohol dehydrogenase
CF60_RS11170	COG1764	response to oxidative stress
CF60_RS11175	COG4608	Belongs to the ABC transporter superfamily
CF60_RS11180	COG0444	Belongs to the ABC transporter superfamily
CF60_RS11185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF60_RS11190	COG0601	transmembrane transport
CF60_RS11195	COG0747	negative chemotaxis
CF60_RS11200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CF60_RS11205	COG2200	EAL domain
CF60_RS11205	COG2202	Pas domain
CF60_RS11205	COG2199	diguanylate cyclase activity
CF60_RS11215	COG1649	PFAM Uncharacterised BCR, COG1649
CF60_RS11220	COG0531	amino acid
CF60_RS11225	COG0076	glutamate decarboxylase activity
CF60_RS11235	COG0612	Peptidase, M16
CF60_RS11240	COG4771	TonB-dependent receptor
CF60_RS11245	COG4178	(ABC) transporter
CF60_RS11250	COG0641	radical SAM
CF60_RS11255	COG3119	arylsulfatase activity
CF60_RS11270	COG0243	molybdopterin cofactor binding
CF60_RS11275	COG3539	Fimbrial protein
CF60_RS11280	COG3539	Fimbrial protein
CF60_RS11285	COG3539	Fimbrial protein
CF60_RS11290	COG3188	usher protein
CF60_RS11300	COG3539	Fimbrial protein
CF60_RS11305	COG4977	sequence-specific DNA binding
CF60_RS11320	COG0667	Aldo Keto reductase
CF60_RS11340	COG3550	peptidyl-serine autophosphorylation
CF60_RS11345	COG1396	sequence-specific DNA binding
CF60_RS11405	COG3781	membrane
CF60_RS11420	COG2199	diguanylate cyclase activity
CF60_RS11430	COG2066	Belongs to the glutaminase family
CF60_RS11435	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS11440	COG0583	DNA-binding transcription factor activity
CF60_RS11460	COG1846	Transcriptional regulator
CF60_RS11465	COG4977	sequence-specific DNA binding
CF60_RS11475	COG2723	6-phospho-beta-galactosidase activity
CF60_RS11485	COG1447	Phosphotransferase system cellobiose-specific component IIA
CF60_RS11490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF60_RS11500	COG2188	Transcriptional regulator
CF60_RS11505	COG0697	spore germination
CF60_RS11510	COG2814	Major facilitator Superfamily
CF60_RS11520	COG3706	GGDEF domain
CF60_RS11525	COG3111	PFAM Bacterial OB fold (BOF) protein
CF60_RS11535	COG0339	signal peptide processing
CF60_RS11540	COG4221	oxidoreductase activity
CF60_RS11545	COG1802	Transcriptional regulator
CF60_RS11555	COG0246	Mannitol dehydrogenase
CF60_RS11560	COG0477	Major facilitator Superfamily
CF60_RS11565	COG1063	alcohol dehydrogenase
CF60_RS11570	COG4948	Mandelate Racemase Muconate Lactonizing
CF60_RS11585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF60_RS11600	COG0243	molybdopterin cofactor binding
CF60_RS11605	COG0243	molybdopterin cofactor binding
CF60_RS11610	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS11615	COG3302	dmso reductase anchor subunit
CF60_RS11620	COG3381	protein complex oligomerization
CF60_RS11630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CF60_RS11635	COG1940	carbohydrate kinase activity
CF60_RS11640	COG0583	DNA-binding transcription factor activity
CF60_RS11645	COG2814	Major facilitator Superfamily
CF60_RS11660	COG3591	Belongs to the peptidase S1B family
CF60_RS11675	COG0628	permease
CF60_RS11680	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CF60_RS11685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CF60_RS11695	COG0531	amino acid
CF60_RS11705	COG3136	membrane protein required for alginate biosynthesis
CF60_RS11710	COG0745	RESPONSE REGULATOR receiver
CF60_RS11715	COG2205	protein histidine kinase activity
CF60_RS11725	COG0114	fumarate hydratase activity
CF60_RS11730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF60_RS11730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF60_RS11735	COG1482	cell wall glycoprotein biosynthetic process
CF60_RS11740	COG5339	Protein conserved in bacteria
CF60_RS11755	COG3250	beta-galactosidase activity
CF60_RS11760	COG1309	transcriptional regulator
CF60_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS11770	COG1609	Transcriptional regulator
CF60_RS11775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS11775	COG1263	PTS System
CF60_RS11780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CF60_RS11790	COG0673	inositol 2-dehydrogenase activity
CF60_RS11825	COG4656	Part of a membrane complex involved in electron transport
CF60_RS11840	COG4658	electron transport chain
CF60_RS11845	COG4659	FMN binding
CF60_RS11855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CF60_RS11865	COG3104	oligopeptide transport
CF60_RS11885	COG3104	oligopeptide transport
CF60_RS11890	COG0625	glutathione transferase activity
CF60_RS11895	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CF60_RS11910	COG3895	Periplasmic Protein
CF60_RS11920	COG3133	Outer membrane lipoprotein
CF60_RS11935	COG1566	PFAM secretion protein HlyD family protein
CF60_RS11940	COG1289	transmembrane transporter activity
CF60_RS11945	COG2032	superoxide dismutase activity
CF60_RS11950	COG4989	oxidoreductase activity
CF60_RS11955	COG3313	Fe-S protein
CF60_RS11960	COG1309	transcriptional regulator
CF60_RS11965	COG1902	pentaerythritol trinitrate reductase activity
CF60_RS11970	COG0346	lactoylglutathione lyase activity
CF60_RS11980	COG1201	RNA secondary structure unwinding
CF60_RS11985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CF60_RS11990	COG0791	NLP P60 protein
CF60_RS11995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CF60_RS12000	COG2814	Major facilitator Superfamily
CF60_RS12015	COG0583	DNA-binding transcription factor activity
CF60_RS12020	COG2814	Major facilitator Superfamily
CF60_RS12025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CF60_RS12030	COG0307	riboflavin synthase, alpha
CF60_RS12060	COG4529	Protein conserved in bacteria
CF60_RS12070	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CF60_RS12075	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS12085	COG2414	aldehyde ferredoxin oxidoreductase
CF60_RS12090	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS12100	COG0469	pyruvate kinase activity
CF60_RS12105	COG4238	major outer membrane lipoprotein
CF60_RS12110	COG1376	ErfK ybiS ycfS ynhG family protein
CF60_RS12125	COG0719	Fe-S assembly protein
CF60_RS12130	COG0396	ATPase activity
CF60_RS12135	COG0719	Fe-S assembly protein
CF60_RS12140	COG0316	Belongs to the HesB IscA family
CF60_RS12150	COG2050	protein possibly involved in aromatic compounds catabolism
CF60_RS12155	COG0247	lactate metabolic process
CF60_RS12155	COG0277	FAD linked oxidase domain protein
CF60_RS12160	COG0628	permease
CF60_RS12170	COG0738	Major facilitator superfamily
CF60_RS12175	COG2271	Major facilitator Superfamily
CF60_RS12190	COG4670	ketone body catabolic process
CF60_RS12195	COG1960	acyl-CoA dehydrogenase activity
CF60_RS12200	COG1917	Cupin 2, conserved barrel domain protein
CF60_RS12200	COG2207	Transcriptional regulator
CF60_RS12210	COG2086	electron transfer activity
CF60_RS12215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CF60_RS12220	COG0644	oxidoreductase
CF60_RS12225	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF60_RS12230	COG0318	PFAM AMP-dependent synthetase and ligase
CF60_RS12235	COG0574	Belongs to the PEP-utilizing enzyme family
CF60_RS12235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF60_RS12250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF60_RS12255	COG4256	Hemin uptake protein
CF60_RS12265	COG2200	EAL domain
CF60_RS12270	COG0791	NLP P60 protein
CF60_RS12280	COG0386	Belongs to the glutathione peroxidase family
CF60_RS12335	COG3137	Salt-induced outer membrane protein
CF60_RS12340	COG1105	Belongs to the carbohydrate kinase PfkB family
CF60_RS12350	COG3001	Fructosamine kinase
CF60_RS12360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF60_RS12365	COG1988	membrane-bound metal-dependent
CF60_RS12370	COG1823	symporter activity
CF60_RS12385	COG0753	catalase activity
CF60_RS12395	COG1486	melibiose metabolic process
CF60_RS12400	COG2169	Transcriptional regulator
CF60_RS12400	COG1917	Cupin 2, conserved barrel domain protein
CF60_RS12405	COG1447	Phosphotransferase system cellobiose-specific component IIA
CF60_RS12410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF60_RS12415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CF60_RS12420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF60_RS12435	COG0322	excinuclease ABC activity
CF60_RS12445	COG3678	ATP-independent chaperone mediated protein folding
CF60_RS12475	COG0708	Exodeoxyribonuclease III
CF60_RS12480	COG0398	Pfam SNARE associated Golgi protein
CF60_RS12490	COG0398	Pfam SNARE associated Golgi protein
CF60_RS12495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF60_RS12500	COG4134	Bacterial extracellular solute-binding protein
CF60_RS12505	COG4135	transport system, permease component
CF60_RS12510	COG4136	ATPase activity
CF60_RS12515	COG2897	thiosulfate sulfurtransferase activity
CF60_RS12520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CF60_RS12525	COG0494	nUDIX hydrolase
CF60_RS12535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CF60_RS12545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CF60_RS12550	COG0709	Synthesizes selenophosphate from selenide and ATP
CF60_RS12560	COG0778	Nitroreductase
CF60_RS12570	COG0616	signal peptide processing
CF60_RS12575	COG0252	asparaginase activity
CF60_RS12580	COG1335	isochorismatase
CF60_RS12585	COG2814	Major facilitator Superfamily
CF60_RS12590	COG1349	DNA-binding transcription factor activity
CF60_RS12595	COG0667	Aldo Keto reductase
CF60_RS12600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF60_RS12605	COG0191	fructose-bisphosphate aldolase activity
CF60_RS12610	COG1063	alcohol dehydrogenase
CF60_RS12615	COG2271	Major facilitator Superfamily
CF60_RS12620	COG1063	alcohol dehydrogenase
CF60_RS12625	COG3139	Protein of unknown function (DUF1315)
CF60_RS12635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CF60_RS12640	COG0676	glucose-6-phosphate 1-epimerase activity
CF60_RS12645	COG0656	L-ascorbic acid biosynthetic process
CF60_RS12650	COG3713	MltA-interacting MipA family protein
CF60_RS12655	COG2766	serine protein kinase
CF60_RS12665	COG2199	diguanylate cyclase activity
CF60_RS12670	COG2199	diguanylate cyclase activity
CF60_RS12675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CF60_RS12690	COG2207	Transcriptional regulator
CF60_RS12695	COG2807	transmembrane transport
CF60_RS12700	COG3189	MarR family transcriptional regulator
CF60_RS12705	COG3042	response to heat
CF60_RS12710	COG2199	diguanylate cyclase activity
CF60_RS12710	COG2203	Gaf domain
CF60_RS12720	COG2261	transglycosylase associated protein
CF60_RS12730	COG3615	Tellurite resistance protein tehB
CF60_RS12745	COG0473	3-isopropylmalate dehydrogenase activity
CF60_RS12750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CF60_RS12755	COG4638	Rieske (2fe-2S)
CF60_RS12760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF60_RS12765	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CF60_RS12770	COG0318	PFAM AMP-dependent synthetase and ligase
CF60_RS12775	COG3065	identical protein binding
CF60_RS12780	COG1214	PFAM Peptidase M22, glycoprotease
CF60_RS12785	COG1199	ATP-dependent helicase activity
CF60_RS12790	COG0251	oxidation-reduction process
CF60_RS12810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CF60_RS12815	COG0494	nUDIX hydrolase
CF60_RS12820	COG1760	l-serine dehydratase
CF60_RS12825	COG2200	EAL domain
CF60_RS12830	COG1253	flavin adenine dinucleotide binding
CF60_RS12840	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS12840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS12845	COG3715	PTS system
CF60_RS12850	COG3716	PTS system mannose fructose sorbose family IID component
CF60_RS12870	COG2226	methyltransferase
CF60_RS12905	COG1414	Transcriptional regulator
CF60_RS12910	COG2814	Major facilitator Superfamily
CF60_RS12920	COG0793	Belongs to the peptidase S41A family
CF60_RS12930	COG1956	GAF domain-containing protein
CF60_RS12935	COG2995	paraquat-inducible protein a
CF60_RS12940	COG3008	intermembrane lipid transfer
CF60_RS12960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CF60_RS12975	COG1276	copper resistance
CF60_RS12980	COG2372	response to copper ion
CF60_RS12990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CF60_RS12995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF60_RS13000	COG1770	oligopeptidase
CF60_RS13015	COG2979	Protein of unknown function (DUF533)
CF60_RS13030	COG3141	response to X-ray
CF60_RS13040	COG0800	Aldolase
CF60_RS13045	COG0129	dihydroxy-acid dehydratase activity
CF60_RS13050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CF60_RS13060	COG1737	Transcriptional regulator
CF60_RS13065	COG0469	pyruvate kinase activity
CF60_RS13075	COG1560	Kdo2-lipid A biosynthetic process
CF60_RS13080	COG0739	heme binding
CF60_RS13085	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CF60_RS13095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CF60_RS13120	COG0217	transcriptional regulatory protein
CF60_RS13125	COG0494	nUDIX hydrolase
CF60_RS13135	COG1335	isochorismatase
CF60_RS13140	COG1801	Protein of unknown function DUF72
CF60_RS13145	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CF60_RS13160	COG0243	molybdopterin cofactor binding
CF60_RS13165	COG3005	denitrification pathway
CF60_RS13175	COG3102	Protein conserved in bacteria
CF60_RS13190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CF60_RS13195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CF60_RS13200	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CF60_RS13205	COG0745	RESPONSE REGULATOR receiver
CF60_RS13215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CF60_RS13220	COG0840	transmembrane signaling receptor activity
CF60_RS13225	COG0840	transmembrane signaling receptor activity
CF60_RS13230	COG0835	chemotaxis
CF60_RS13240	COG1360	Flagellar Motor Protein
CF60_RS13245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CF60_RS13260	COG0589	response to stress
CF60_RS13270	COG1877	trehalose-phosphatase activity
CF60_RS13275	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF60_RS13280	COG1129	ABC transporter
CF60_RS13285	COG1879	ABC-type sugar transport system periplasmic component
CF60_RS13290	COG1528	Iron-storage protein
CF60_RS13310	COG1528	Iron-storage protein
CF60_RS13320	COG0814	amino acid
CF60_RS13355	COG2197	response regulator
CF60_RS13370	COG2197	response regulator
CF60_RS13375	COG1126	abc transporter atp-binding protein
CF60_RS13380	COG0765	amino acid transport
CF60_RS13390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF60_RS13400	COG1191	sigma factor activity
CF60_RS13410	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CF60_RS13415	COG1516	flagellar protein fliS
CF60_RS13425	COG0366	Alpha amylase catalytic
CF60_RS13435	COG2391	methyltransferase activity
CF60_RS13440	COG0425	Belongs to the sulfur carrier protein TusA family
CF60_RS13445	COG2135	peptidase activity
CF60_RS13450	COG0454	-acetyltransferase
CF60_RS13475	COG1766	The M ring may be actively involved in energy transduction
CF60_RS13480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF60_RS13485	COG1317	bacterial-type flagellum organization
CF60_RS13490	COG1157	protein secretion by the type III secretion system
CF60_RS13495	COG2882	bacterial-type flagellum organization
CF60_RS13500	COG3144	bacterial-type flagellum assembly
CF60_RS13505	COG1580	Controls the rotational direction of flagella during chemotaxis
CF60_RS13510	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF60_RS13515	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CF60_RS13520	COG3190	flagellar
CF60_RS13525	COG1338	Plays a role in the flagellum-specific transport system
CF60_RS13530	COG1987	bacterial-type flagellum assembly
CF60_RS13535	COG1684	flagellar biosynthetic protein fliR
CF60_RS13540	COG2197	response regulator
CF60_RS13565	COG5475	Uncharacterized small protein (DUF2158)
CF60_RS13570	COG2354	Protein conserved in bacteria
CF60_RS13575	COG0697	spore germination
CF60_RS13580	COG3727	T/G mismatch-specific endonuclease activity
CF60_RS13585	COG0270	DNA (cytosine-5-)-methyltransferase activity
CF60_RS13590	COG1418	mRNA catabolic process
CF60_RS13600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF60_RS13615	COG2205	protein histidine kinase activity
CF60_RS13620	COG0745	RESPONSE REGULATOR receiver
CF60_RS13625	COG2351	hydroxyisourate hydrolase activity
CF60_RS13640	COG3443	Belongs to the bacterial solute-binding protein 9 family
CF60_RS13665	COG4932	domain protein
CF60_RS13665	COG1388	LysM domain
CF60_RS13665	COG2373	Large extracellular alpha-helical protein
CF60_RS13675	COG0477	Major facilitator Superfamily
CF60_RS13680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CF60_RS13685	COG0217	transcriptional regulatory protein
CF60_RS13695	COG3209	COG3209 Rhs family protein
CF60_RS13705	COG3423	Transcriptional regulator
CF60_RS13730	COG0534	Mate efflux family protein
CF60_RS13740	COG0583	DNA-binding transcription factor activity
CF60_RS13745	COG0583	DNA-binding transcription factor activity
CF60_RS13755	COG1376	ErfK ybiS ycfS ynhG family protein
CF60_RS13770	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CF60_RS13790	COG1289	transmembrane transporter activity
CF60_RS13800	COG1686	Belongs to the peptidase S11 family
CF60_RS13805	COG2925	Exonuclease
CF60_RS13810	COG0531	amino acid
CF60_RS13815	COG0583	DNA-binding transcription factor activity
CF60_RS13820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF60_RS13825	COG4115	mRNA cleavage
CF60_RS13830	COG2161	toxin-antitoxin pair type II binding
CF60_RS13840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CF60_RS13850	COG0131	Imidazoleglycerol-phosphate dehydratase
CF60_RS13850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CF60_RS13855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CF60_RS13880	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF60_RS13890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CF60_RS13915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF60_RS13920	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CF60_RS13930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CF60_RS13935	COG1091	dTDP-4-dehydrorhamnose reductase activity
CF60_RS13940	COG1088	dTDP-glucose 4,6-dehydratase activity
CF60_RS13945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CF60_RS13955	COG0438	transferase activity, transferring glycosyl groups
CF60_RS13960	COG2327	Polysaccharide pyruvyl transferase
CF60_RS13965	COG2244	polysaccharide biosynthetic process
CF60_RS13970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CF60_RS13975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CF60_RS13980	COG0662	Cupin 2, conserved barrel domain protein
CF60_RS13980	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CF60_RS13985	COG0297	glycogen (starch) synthase activity
CF60_RS13990	COG1051	belongs to the nudix hydrolase family
CF60_RS13995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CF60_RS14000	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CF60_RS14010	COG1216	Glycosyl transferase, family 2
CF60_RS14020	COG0438	transferase activity, transferring glycosyl groups
CF60_RS14025	COG1045	serine acetyltransferase
CF60_RS14030	COG0463	Glycosyl transferase, family 2
CF60_RS14035	COG3206	protein involved in exopolysaccharide biosynthesis
CF60_RS14035	COG0489	protein tyrosine kinase activity
CF60_RS14040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CF60_RS14045	COG1596	polysaccharide export
CF60_RS14050	COG1253	flavin adenine dinucleotide binding
CF60_RS14055	COG2982	Protein involved in outer membrane biogenesis
CF60_RS14065	COG0572	uridine kinase
CF60_RS14070	COG2982	Protein involved in outer membrane biogenesis
CF60_RS14080	COG0572	uridine kinase
CF60_RS14085	COG3447	MASE1 domain protein
CF60_RS14085	COG5001	Diguanylate cyclase
CF60_RS14085	COG5002	protein histidine kinase activity
CF60_RS14090	COG3447	MASE1 domain protein
CF60_RS14090	COG5001	Diguanylate cyclase
CF60_RS14090	COG5002	protein histidine kinase activity
CF60_RS14095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CF60_RS14100	COG0443	Heat shock 70 kDa protein
CF60_RS14105	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
CF60_RS14110	COG0631	protein serine/threonine phosphatase activity
CF60_RS14115	COG4245	von Willebrand factor, type A
CF60_RS14140	COG2205	protein histidine kinase activity
CF60_RS14145	COG0745	RESPONSE REGULATOR receiver
CF60_RS14155	COG0826	peptidase U32
CF60_RS14200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CF60_RS14220	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CF60_RS14325	COG4695	Portal protein
CF60_RS14380	COG4974	Belongs to the 'phage' integrase family
CF60_RS14405	COG1063	alcohol dehydrogenase
CF60_RS14410	COG3775	system Galactitol-specific IIC component
CF60_RS14415	COG3414	Phosphotransferase system galactitol-specific IIB component
CF60_RS14420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS14425	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
CF60_RS14435	COG1830	Aldolase
CF60_RS14440	COG2211	Major facilitator Superfamily
CF60_RS14445	COG1397	ADP-ribosylglycohydrolase
CF60_RS14450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF60_RS14455	COG2188	Transcriptional regulator
CF60_RS14460	COG3757	hydrolase, family 25
CF60_RS14465	COG0351	phosphomethylpyrimidine kinase
CF60_RS14485	COG5455	response to cobalt ion
CF60_RS14495	COG3188	usher protein
CF60_RS14500	COG3121	Chaperone
CF60_RS14505	COG3539	Fimbrial protein
CF60_RS14520	COG0489	protein tyrosine kinase activity
CF60_RS14530	COG3831	ATPase activity
CF60_RS14535	COG3831	ATPase activity
CF60_RS14550	COG0714	Associated with various cellular activities
CF60_RS14555	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CF60_RS14560	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CF60_RS14565	COG4715	Zinc finger, swim domain protein
CF60_RS14570	COG4808	Protein conserved in bacteria
CF60_RS14575	COG4807	Protein conserved in bacteria
CF60_RS14580	COG3279	Response regulator of the LytR AlgR family
CF60_RS14585	COG3275	phosphorelay sensor kinase activity
CF60_RS14590	COG0789	Transcriptional regulator
CF60_RS14600	COG1174	glycine betaine transport
CF60_RS14605	COG1125	glycine betaine transport
CF60_RS14610	COG1174	glycine betaine transport
CF60_RS14615	COG1732	Glycine betaine
CF60_RS14620	COG1472	Belongs to the glycosyl hydrolase 3 family
CF60_RS14625	COG0277	FAD linked oxidase domain protein
CF60_RS14630	COG1686	Belongs to the peptidase S11 family
CF60_RS14640	COG0586	Pfam SNARE associated Golgi protein
CF60_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS14660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF60_RS14665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF60_RS14670	COG0625	glutathione transferase activity
CF60_RS14685	COG2271	Major facilitator Superfamily
CF60_RS14700	COG1346	cytolysis
CF60_RS14710	COG2949	membrane
CF60_RS14720	COG0493	'glutamate synthase
CF60_RS14725	COG0167	dihydroorotate dehydrogenase activity
CF60_RS14725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CF60_RS14730	COG4211	Belongs to the binding-protein-dependent transport system permease family
CF60_RS14735	COG1129	ABC transporter
CF60_RS14740	COG1879	ABC-type sugar transport system periplasmic component
CF60_RS14745	COG1609	Transcriptional regulator
CF60_RS14755	COG2311	Membrane
CF60_RS14775	COG4771	TonB-dependent receptor
CF60_RS14785	COG0833	amino acid
CF60_RS14790	COG0583	DNA-binding transcription factor activity
CF60_RS14795	COG2855	membrane
CF60_RS14805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF60_RS14805	COG1522	sequence-specific DNA binding
CF60_RS14810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF60_RS14820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF60_RS14825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CF60_RS14830	COG2313	pseudouridylate synthase activity
CF60_RS14835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF60_RS14840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS14840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS14840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CF60_RS14845	COG1105	Belongs to the carbohydrate kinase PfkB family
CF60_RS14850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS14850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS14855	COG2814	Major facilitator Superfamily
CF60_RS14870	COG0246	Mannitol dehydrogenase
CF60_RS14875	COG0523	cobalamin synthesis protein
CF60_RS14880	COG0671	phosphoesterase, PA-phosphatase related
CF60_RS14885	COG0791	NLP P60 protein
CF60_RS14890	COG2200	EAL domain
CF60_RS14895	COG4166	transmembrane transport
CF60_RS14900	COG4174	ABC transporter (Permease)
CF60_RS14905	COG4239	(ABC) transporter, permease
CF60_RS14910	COG4172	Belongs to the ABC transporter superfamily
CF60_RS14920	COG2814	Major facilitator Superfamily
CF60_RS14925	COG1187	pseudouridine synthase activity
CF60_RS14930	COG1061	Type III restriction enzyme res subunit
CF60_RS14950	COG3083	sulfuric ester hydrolase activity
CF60_RS14960	COG3468	outer membrane autotransporter barrel domain protein
CF60_RS14970	COG2197	response regulator
CF60_RS14975	COG4235	cytochrome complex assembly
CF60_RS14975	COG3088	subunit of a heme lyase
CF60_RS14980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CF60_RS14985	COG1138	Cytochrome C-type biogenesis protein
CF60_RS14995	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF60_RS15000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF60_RS15005	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CF60_RS15010	COG4133	protoheme IX ABC transporter activity
CF60_RS15015	COG3005	denitrification pathway
CF60_RS15020	COG3043	anaerobic respiration
CF60_RS15025	COG0348	domain, Protein
CF60_RS15030	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS15040	COG3062	negative regulation of establishment of protein localization
CF60_RS15045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS15045	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS15065	COG4615	Cyclic peptide transporter
CF60_RS15070	COG3145	DNA-N1-methyladenine dioxygenase activity
CF60_RS15075	COG2169	Transcriptional regulator
CF60_RS15075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CF60_RS15080	COG1477	protein flavinylation
CF60_RS15085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF60_RS15095	COG0642	Histidine kinase
CF60_RS15095	COG2198	Histidine kinase
CF60_RS15100	COG2197	response regulator
CF60_RS15105	COG0784	Response regulator, receiver
CF60_RS15105	COG2205	protein histidine kinase activity
CF60_RS15115	COG2204	response regulator
CF60_RS15120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CF60_RS15125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CF60_RS15130	COG2031	fatty acid transporter
CF60_RS15135	COG0183	Belongs to the thiolase family
CF60_RS15140	COG4676	Protein conserved in bacteria
CF60_RS15145	COG5445	Predicted secreted protein (DUF2300)
CF60_RS15150	COG2373	Large extracellular alpha-helical protein
CF60_RS15155	COG3234	Protein of unknown function (DUF1175)
CF60_RS15160	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
CF60_RS15165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF60_RS15185	COG2801	Transposase and inactivated derivatives
CF60_RS15190	COG3468	outer membrane autotransporter barrel domain protein
CF60_RS15200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF60_RS15205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF60_RS15210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF60_RS15215	COG3642	lipopolysaccharide core region biosynthetic process
CF60_RS15220	COG2814	Major facilitator Superfamily
CF60_RS15225	COG0583	DNA-binding transcription factor activity
CF60_RS15230	COG0584	glycerophosphoryl diester phosphodiesterase
CF60_RS15235	COG2271	Major facilitator Superfamily
CF60_RS15240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CF60_RS15250	COG0247	lactate metabolic process
CF60_RS15255	COG5464	transposase or invertase
CF60_RS15270	COG2271	Major facilitator Superfamily
CF60_RS15280	COG1414	Transcriptional regulator
CF60_RS15345	COG0318	PFAM AMP-dependent synthetase and ligase
CF60_RS15355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CF60_RS15370	COG1169	isochorismate synthase
CF60_RS15375	COG4575	ribosome binding
CF60_RS15380	COG2153	protein acetylation
CF60_RS15395	COG2234	aminopeptidase activity
CF60_RS15410	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF60_RS15415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CF60_RS15425	COG0839	Belongs to the complex I subunit 6 family
CF60_RS15440	COG1034	ATP synthesis coupled electron transport
CF60_RS15445	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CF60_RS15450	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CF60_RS15470	COG0583	DNA-binding transcription factor activity
CF60_RS15475	COG0436	Aminotransferase
CF60_RS15485	COG0471	metal ion transport
CF60_RS15485	COG0490	domain, Protein
CF60_RS15490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF60_RS15510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CF60_RS15515	COG0280	phosphate acetyltransferase
CF60_RS15515	COG0857	belongs to the CobB CobQ family
CF60_RS15520	COG1288	antiporter activity
CF60_RS15525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CF60_RS15530	COG0622	Phosphoesterase
CF60_RS15535	COG0625	glutathione transferase activity
CF60_RS15540	COG0625	glutathione transferase activity
CF60_RS15545	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CF60_RS15550	COG1090	epimerase
CF60_RS15555	COG5464	transposase or invertase
CF60_RS15560	COG4598	ABC transporter
CF60_RS15565	COG4160	amino acid transport
CF60_RS15570	COG4215	(ABC) transporter
CF60_RS15575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF60_RS15580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF60_RS15585	COG0163	prenyltransferase activity
CF60_RS15590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CF60_RS15595	COG1286	toxin biosynthetic process
CF60_RS15600	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CF60_RS15605	COG0285	dihydrofolate synthase activity
CF60_RS15615	COG0586	Pfam SNARE associated Golgi protein
CF60_RS15625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF60_RS15640	COG2814	Major facilitator Superfamily
CF60_RS15645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CF60_RS15660	COG3101	peptidyl-lysine hydroxylation
CF60_RS15665	COG0730	response to heat
CF60_RS15690	COG2801	Transposase and inactivated derivatives
CF60_RS15710	COG3539	Fimbrial protein
CF60_RS15715	COG3539	Fimbrial protein
CF60_RS15720	COG3539	Fimbrial protein
CF60_RS15725	COG3121	Chaperone
CF60_RS15730	COG3188	usher protein
CF60_RS15735	COG3539	Fimbrial protein
CF60_RS15740	COG2062	phosphohistidine phosphatase, SixA
CF60_RS15755	COG3691	Protein conserved in bacteria
CF60_RS15760	COG2067	long-chain fatty acid transport protein
CF60_RS15770	COG2853	Lipoprotein
CF60_RS15775	COG2116	formate transmembrane transporter activity
CF60_RS15810	COG2610	gluconate transmembrane transporter activity
CF60_RS15820	COG0477	Major facilitator Superfamily
CF60_RS15825	COG1566	PFAM secretion protein HlyD family protein
CF60_RS15830	COG2197	response regulator
CF60_RS15835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF60_RS15835	COG2205	protein histidine kinase activity
CF60_RS15835	COG2198	Histidine kinase
CF60_RS15835	COG0784	Response regulator, receiver
CF60_RS15840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CF60_RS15845	COG0679	Auxin Efflux Carrier
CF60_RS15850	COG0028	Belongs to the TPP enzyme family
CF60_RS15880	COG1560	Kdo2-lipid A biosynthetic process
CF60_RS15885	COG0436	Aminotransferase
CF60_RS15890	COG3275	phosphorelay sensor kinase activity
CF60_RS15895	COG3279	Response regulator of the LytR AlgR family
CF60_RS15900	COG2207	Transcriptional regulator
CF60_RS15910	COG1363	Peptidase, m42
CF60_RS15915	COG0006	proline dipeptidase activity
CF60_RS15920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS15925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CF60_RS15955	COG2200	EAL domain
CF60_RS15955	COG2199	diguanylate cyclase activity
CF60_RS15970	COG3415	Transposase
CF60_RS15975	COG3415	Transposase
CF60_RS16005	COG0583	DNA-binding transcription factor activity
CF60_RS16015	COG2211	Major facilitator Superfamily
CF60_RS16020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CF60_RS16030	COG0583	DNA-binding transcription factor activity
CF60_RS16035	COG0385	Bile acid
CF60_RS16040	COG3530	Putative quorum-sensing-regulated virulence factor
CF60_RS16060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CF60_RS16065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS16070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CF60_RS16075	COG2190	(PTS) system
CF60_RS16090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CF60_RS16095	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CF60_RS16100	COG4208	sulfate ABC transporter
CF60_RS16105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CF60_RS16110	COG4150	thiosulfate binding
CF60_RS16115	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS16130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS16130	COG1263	PTS System
CF60_RS16135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CF60_RS16140	COG2837	iron assimilation
CF60_RS16160	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF60_RS16170	COG2207	Transcriptional regulator
CF60_RS16175	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CF60_RS16180	COG4816	utilization protein
CF60_RS16190	COG4303	Ethanolamine ammonia lyase large subunit
CF60_RS16195	COG4819	ethanolamine utilization protein
CF60_RS16200	COG3192	ethanolamine utilization protein
CF60_RS16205	COG1454	alcohol dehydrogenase
CF60_RS16210	COG4820	ethanolamine utilization protein (EutJ)
CF60_RS16215	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS16220	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CF60_RS16225	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CF60_RS16230	COG0280	phosphate acetyltransferase
CF60_RS16235	COG4812	Cobalamin adenosyltransferase
CF60_RS16240	COG4766	ethanolamine catabolic process
CF60_RS16245	COG4917	ethanolamine utilization protein
CF60_RS16250	COG4810	utilization protein
CF60_RS16255	COG0280	phosphate acetyltransferase
CF60_RS16255	COG0281	malic enzyme
CF60_RS16260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CF60_RS16265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CF60_RS16270	COG5342	invasion associated locus B
CF60_RS16280	COG0493	'glutamate synthase
CF60_RS16280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS16285	COG3850	Histidine kinase
CF60_RS16290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF60_RS16300	COG1393	Belongs to the ArsC family
CF60_RS16335	COG2321	neutral zinc metallopeptidase
CF60_RS16350	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CF60_RS16360	COG2716	regulation of RNA biosynthetic process
CF60_RS16365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CF60_RS16370	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS16375	COG0651	ATP synthesis coupled electron transport
CF60_RS16380	COG0650	Formate hydrogenlyase subunit 4
CF60_RS16385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CF60_RS16390	COG4237	Hydrogenase 4 membrane
CF60_RS16395	COG0651	ATP synthesis coupled electron transport
CF60_RS16400	COG3261	NADH dehydrogenase
CF60_RS16400	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CF60_RS16405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CF60_RS16410	COG3260	NADH ubiquinone oxidoreductase 20
CF60_RS16420	COG3604	Transcriptional regulator
CF60_RS16425	COG2116	formate transmembrane transporter activity
CF60_RS16430	COG0628	permease
CF60_RS16435	COG4783	chaperone-mediated protein folding
CF60_RS16440	COG1393	Belongs to the ArsC family
CF60_RS16450	COG2233	PERMEase
CF60_RS16465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CF60_RS16470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CF60_RS16475	COG0248	Ppx GppA phosphatase
CF60_RS16480	COG2200	EAL domain
CF60_RS16495	COG3133	Outer membrane lipoprotein
CF60_RS16510	COG0517	IMP dehydrogenase activity
CF60_RS16510	COG0516	GMP reductase activity
CF60_RS16535	COG1645	bacterial-type flagellum-dependent swarming motility
CF60_RS16550	COG2976	Protein conserved in bacteria
CF60_RS16580	COG4953	penicillin-binding protein 1C
CF60_RS16585	COG2373	Large extracellular alpha-helical protein
CF60_RS16590	COG2897	thiosulfate sulfurtransferase activity
CF60_RS16605	COG2975	iron-sulfur cluster assembly
CF60_RS16610	COG0633	Ferredoxin
CF60_RS16630	COG0822	iron-sulfur transferase activity
CF60_RS16650	COG0483	inositol monophosphate 1-phosphatase activity
CF60_RS16655	COG1073	alpha beta
CF60_RS16660	COG3711	transcriptional antiterminator
CF60_RS16665	COG2814	Major facilitator Superfamily
CF60_RS16670	COG0583	DNA-binding transcription factor activity
CF60_RS16675	COG4638	Rieske (2fe-2S)
CF60_RS16700	COG2259	Doxx family
CF60_RS16705	COG2017	converts alpha-aldose to the beta-anomer
CF60_RS16710	COG1063	alcohol dehydrogenase
CF60_RS16715	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF60_RS16720	COG1129	ABC transporter
CF60_RS16725	COG1879	ABC-type sugar transport system periplasmic component
CF60_RS16730	COG0457	Tetratricopeptide repeat
CF60_RS16735	COG1940	carbohydrate kinase activity
CF60_RS16750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CF60_RS16750	COG1017	nitric oxide dioxygenase activity
CF60_RS16755	COG0347	Belongs to the P(II) protein family
CF60_RS16760	COG2204	response regulator
CF60_RS16765	COG3170	Tfp pilus assembly protein FimV
CF60_RS16770	COG2205	protein histidine kinase activity
CF60_RS16775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CF60_RS16775	COG0047	phosphoribosylformylglycinamidine synthase activity
CF60_RS16790	COG0560	Phosphoserine phosphatase
CF60_RS16795	COG1737	Transcriptional regulator
CF60_RS16800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS16825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CF60_RS16845	COG0681	Belongs to the peptidase S26 family
CF60_RS16855	COG3086	response to oxidative stress
CF60_RS16860	COG3026	antisigma factor binding
CF60_RS16865	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CF60_RS16870	COG1595	DNA-templated transcription, initiation
CF60_RS16880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CF60_RS16890	COG0513	Belongs to the DEAD box helicase family
CF60_RS16895	COG0583	DNA-binding transcription factor activity
CF60_RS16915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF60_RS16925	COG3118	belongs to the thioredoxin family
CF60_RS16930	COG3148	PFAM DTW domain containing protein
CF60_RS16935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CF60_RS16935	COG1042	CoA-binding domain protein
CF60_RS16935	COG0045	succinate-CoA ligase (ADP-forming) activity
CF60_RS16940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF60_RS16945	COG5544	Lipoprotein
CF60_RS16950	COG0477	Major facilitator Superfamily
CF60_RS16955	COG2801	Transposase and inactivated derivatives
CF60_RS16990	COG0542	response to heat
CF60_RS17000	COG0564	pseudouridine synthase activity
CF60_RS17005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF60_RS17015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF60_RS17020	COG1605	Chorismate mutase
CF60_RS17020	COG0077	Prephenate dehydratase
CF60_RS17025	COG0287	Prephenate dehydrogenase
CF60_RS17025	COG1605	Chorismate mutase
CF60_RS17030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CF60_RS17045	COG2199	diguanylate cyclase activity
CF60_RS17050	COG2885	chlorophyll binding
CF60_RS17075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CF60_RS17080	COG4137	Cytochrome C assembly protein
CF60_RS17085	COG4536	flavin adenine dinucleotide binding
CF60_RS17105	COG0497	DNA recombination
CF60_RS17110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CF60_RS17120	COG2867	negative regulation of translational initiation
CF60_RS17130	COG0582	viral genome integration into host DNA
CF60_RS17245	COG0366	Alpha amylase catalytic
CF60_RS17255	COG0579	oxidoreductase
CF60_RS17260	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS17265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CF60_RS17270	COG1113	amino acid transport
CF60_RS17275	COG1802	Transcriptional regulator
CF60_RS17280	COG1652	LysM domain
CF60_RS17285	COG0401	homolog of Blt101
CF60_RS17290	COG0640	Transcriptional regulator
CF60_RS17295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF60_RS17300	COG2916	Histone family protein nucleoid-structuring protein H-NS
CF60_RS17315	COG4575	ribosome binding
CF60_RS17320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CF60_RS17325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CF60_RS17330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF60_RS17340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF60_RS17345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CF60_RS17350	COG4175	Glycine betaine
CF60_RS17355	COG4176	ABC-type proline glycine betaine transport system permease component
CF60_RS17360	COG2113	Glycine betaine
CF60_RS17365	COG2814	Major facilitator Superfamily
CF60_RS17370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CF60_RS17380	COG1846	Transcriptional regulator
CF60_RS17385	COG1566	PFAM secretion protein HlyD family protein
CF60_RS17390	COG2814	Major facilitator Superfamily
CF60_RS17405	COG1238	metal cluster binding
CF60_RS17410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF60_RS17445	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CF60_RS17470	COG1546	Belongs to the CinA family
CF60_RS17475	COG2951	lytic endotransglycosylase activity
CF60_RS17480	COG3730	PTS system glucitol sorbitol-specific
CF60_RS17485	COG3732	PTS system glucitol sorbitol-specific
CF60_RS17495	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS17500	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS17505	COG1349	DNA-binding transcription factor activity
CF60_RS17530	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CF60_RS17535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS17540	COG1609	Transcriptional regulator
CF60_RS17545	COG1263	PTS System
CF60_RS17545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS17550	COG2723	6-phospho-beta-galactosidase activity
CF60_RS17555	COG5499	transcription regulator containing HTH domain
CF60_RS17560	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF60_RS17570	COG3260	NADH ubiquinone oxidoreductase 20
CF60_RS17580	COG3261	NADH dehydrogenase
CF60_RS17580	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CF60_RS17585	COG0650	Formate hydrogenlyase subunit 4
CF60_RS17590	COG0651	ATP synthesis coupled electron transport
CF60_RS17595	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS17610	COG0375	protein maturation
CF60_RS17615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CF60_RS17620	COG0298	carbon dioxide binding
CF60_RS17625	COG0409	Hydrogenase expression formation protein
CF60_RS17630	COG0309	Hydrogenase expression formation protein (HypE)
CF60_RS17635	COG3604	Transcriptional regulator
CF60_RS17660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CF60_RS17670	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CF60_RS17675	COG0163	prenyltransferase activity
CF60_RS17685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF60_RS17690	COG1388	LysM domain
CF60_RS17690	COG4942	peptidase
CF60_RS17745	COG2234	aminopeptidase activity
CF60_RS17750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CF60_RS17755	COG1518	maintenance of DNA repeat elements
CF60_RS17770	COG1857	crispr-associated protein
CF60_RS17785	COG1203	CRISPR-associated helicase, Cas3
CF60_RS17810	COG0720	synthase
CF60_RS17815	COG0644	oxidoreductase
CF60_RS17820	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CF60_RS17825	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CF60_RS17830	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CF60_RS17835	COG2086	electron transfer activity
CF60_RS17840	COG0477	Major facilitator Superfamily
CF60_RS17845	COG0277	FAD linked oxidase domain protein
CF60_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS17855	COG2223	nitrite transmembrane transporter activity
CF60_RS17865	COG0602	queuosine metabolic process
CF60_RS17875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CF60_RS17890	COG3956	TIGRFAM MazG family protein
CF60_RS17895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF60_RS17905	COG4999	Histidine kinase
CF60_RS17905	COG3437	response regulator, receiver
CF60_RS17905	COG3850	Histidine kinase
CF60_RS17905	COG2205	protein histidine kinase activity
CF60_RS17910	COG4948	Mandelate Racemase Muconate Lactonizing
CF60_RS17915	COG4948	Mandelate Racemase Muconate Lactonizing
CF60_RS17920	COG2271	Major facilitator Superfamily
CF60_RS17925	COG0716	FMN binding
CF60_RS17930	COG0564	pseudouridine synthase activity
CF60_RS17935	COG3098	single-species biofilm formation
CF60_RS17955	COG1611	Belongs to the LOG family
CF60_RS17960	COG0814	amino acid
CF60_RS17965	COG1760	l-serine dehydratase
CF60_RS17975	COG1454	alcohol dehydrogenase
CF60_RS17980	COG0235	Class ii aldolase
CF60_RS17985	COG0738	Major facilitator superfamily
CF60_RS17995	COG1070	Carbohydrate kinase
CF60_RS18005	COG1349	DNA-binding transcription factor activity
CF60_RS18015	COG2363	Small membrane protein
CF60_RS18020	COG0583	DNA-binding transcription factor activity
CF60_RS18030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CF60_RS18035	COG2166	iron-sulfur cluster assembly
CF60_RS18040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CF60_RS18045	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CF60_RS18065	COG0860	N-Acetylmuramoyl-L-alanine amidase
CF60_RS18070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CF60_RS18070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CF60_RS18075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CF60_RS18080	COG1074	ATP-dependent DNA helicase activity
CF60_RS18090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CF60_RS18095	COG4967	type IV pilus modification protein PilV
CF60_RS18105	COG4795	General secretion pathway protein
CF60_RS18110	COG2165	general secretion pathway protein
CF60_RS18125	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CF60_RS18150	COG0861	Integral membrane protein TerC family
CF60_RS18160	COG0667	Aldo Keto reductase
CF60_RS18190	COG1609	Transcriptional regulator
CF60_RS18200	COG0583	DNA-binding transcription factor activity
CF60_RS18205	COG1794	racemase activity, acting on amino acids and derivatives
CF60_RS18210	COG2814	Major facilitator Superfamily
CF60_RS18215	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS18225	COG0183	Belongs to the thiolase family
CF60_RS18230	COG0814	amino acid
CF60_RS18235	COG2771	luxR family
CF60_RS18240	COG3710	Transcriptional regulator
CF60_RS18285	COG2207	Transcriptional regulator
CF60_RS18295	COG3387	PFAM Glycoside hydrolase 15-related
CF60_RS18305	COG4942	peptidase
CF60_RS18310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF60_RS18315	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF60_RS18320	COG2080	2 iron, 2 sulfur cluster binding
CF60_RS18325	COG3829	transcription factor binding
CF60_RS18330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CF60_RS18335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF60_RS18340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CF60_RS18350	COG0549	Belongs to the carbamate kinase family
CF60_RS18355	COG3608	succinylglutamate desuccinylase aspartoacylase
CF60_RS18355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CF60_RS18360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CF60_RS18365	COG2068	MobA-Related Protein
CF60_RS18370	COG0493	'glutamate synthase
CF60_RS18370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS18375	COG0402	S-adenosylhomocysteine deaminase activity
CF60_RS18380	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CF60_RS18385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CF60_RS18385	COG2080	2 iron, 2 sulfur cluster binding
CF60_RS18390	COG2233	PERMEase
CF60_RS18395	COG0402	S-adenosylhomocysteine deaminase activity
CF60_RS18400	COG2252	PERMEase
CF60_RS18405	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS18410	COG0493	'glutamate synthase
CF60_RS18410	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS18420	COG2233	PERMEase
CF60_RS18435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CF60_RS18445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CF60_RS18450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CF60_RS18455	COG4974	Belongs to the 'phage' integrase family
CF60_RS18460	COG0716	FMN binding
CF60_RS18470	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CF60_RS18480	COG1272	protein, Hemolysin III
CF60_RS18490	COG2723	6-phospho-beta-galactosidase activity
CF60_RS18510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF60_RS18515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CF60_RS18520	COG0006	proline dipeptidase activity
CF60_RS18535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CF60_RS18545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CF60_RS18560	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF60_RS18560	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CF60_RS18565	COG1703	isobutyryl-CoA mutase activity
CF60_RS18575	COG0427	acetyl-CoA hydrolase
CF60_RS18580	COG0583	DNA-binding transcription factor activity
CF60_RS18585	COG2968	Membrane
CF60_RS18590	COG1279	arginine transmembrane transporter activity
CF60_RS18595	COG0668	transmembrane transport
CF60_RS18600	COG0191	fructose-bisphosphate aldolase activity
CF60_RS18615	COG1072	(Pantothenic acid kinase))
CF60_RS18625	COG1494	fructose-1,6-bisphosphatase
CF60_RS18630	COG1063	alcohol dehydrogenase
CF60_RS18635	COG2213	PTS system mannitol-specific
CF60_RS18640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS18645	COG0330	HflC and HflK could
CF60_RS18650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CF60_RS18655	COG0501	Belongs to the peptidase M48B family
CF60_RS18670	COG2801	Transposase and inactivated derivatives
CF60_RS18685	COG1166	arginine decarboxylase activity
CF60_RS18710	COG2814	Major facilitator Superfamily
CF60_RS18720	COG2356	endonuclease I
CF60_RS18725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CF60_RS18730	COG0189	ligase activity
CF60_RS18745	COG2805	Type II/IV secretion system protein
CF60_RS18750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CF60_RS18755	COG0762	integral membrane protein
CF60_RS18770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CF60_RS18775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CF60_RS18780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CF60_RS18795	COG0252	asparaginase activity
CF60_RS18810	COG3171	Protein conserved in bacteria
CF60_RS18820	COG1194	a g-specific adenine glycosylase
CF60_RS18835	COG2211	Major facilitator Superfamily
CF60_RS18840	COG1982	Orn Lys Arg decarboxylase major
CF60_RS18845	COG1811	Na channel or pump
CF60_RS18895	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CF60_RS18925	COG2165	general secretion pathway protein
CF60_RS18930	COG1459	type II secretion system
CF60_RS18935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF60_RS18955	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CF60_RS18960	COG3064	Membrane
CF60_RS18970	COG1620	l-lactate permease
CF60_RS18975	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CF60_RS18980	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CF60_RS18985	COG0247	lactate metabolic process
CF60_RS18990	COG0277	FAD linked oxidase domain protein
CF60_RS18995	COG0277	FAD linked oxidase domain protein
CF60_RS19000	COG2186	Transcriptional regulator
CF60_RS19005	COG0456	acetyltransferase
CF60_RS19010	COG0318	PFAM AMP-dependent synthetase and ligase
CF60_RS19020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CF60_RS19025	COG0156	8-amino-7-oxononanoate synthase activity
CF60_RS19035	COG0795	lipopolysaccharide-transporting ATPase activity
CF60_RS19040	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CF60_RS19050	COG2244	polysaccharide biosynthetic process
CF60_RS19055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF60_RS19060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF60_RS19065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CF60_RS19070	COG0306	phosphate transporter
CF60_RS19075	COG0754	glutathionylspermidine amidase activity
CF60_RS19080	COG0625	glutathione transferase activity
CF60_RS19085	COG0298	carbon dioxide binding
CF60_RS19095	COG1773	rubredoxin
CF60_RS19100	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CF60_RS19105	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CF60_RS19110	COG5557	Pfam Polysulphide reductase, NrfD
CF60_RS19115	COG0437	4 iron, 4 sulfur cluster binding
CF60_RS19120	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CF60_RS19140	COG0667	Aldo Keto reductase
CF60_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
CF60_RS19155	COG0848	biopolymer transport protein
CF60_RS19160	COG0811	peptide transport
CF60_RS19170	COG0626	cystathionine gamma-synthase activity
CF60_RS19175	COG0586	Pfam SNARE associated Golgi protein
CF60_RS19180	COG2207	Transcriptional regulator
CF60_RS19190	COG1979	alcohol dehydrogenase
CF60_RS19195	COG0656	L-ascorbic acid biosynthetic process
CF60_RS19205	COG4238	major outer membrane lipoprotein
CF60_RS19210	COG1032	radical SAM domain protein
CF60_RS19215	COG2132	Multicopper oxidase
CF60_RS19220	COG0204	Acyl-transferase
CF60_RS19225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CF60_RS19230	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CF60_RS19235	COG3111	PFAM Bacterial OB fold (BOF) protein
CF60_RS19240	COG0745	RESPONSE REGULATOR receiver
CF60_RS19245	COG0642	Histidine kinase
CF60_RS19265	COG2249	NAD(P)H dehydrogenase (quinone) activity
CF60_RS19270	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CF60_RS19275	COG1737	Transcriptional regulator
CF60_RS19285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF60_RS19290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF60_RS19295	COG1120	ATPase activity
CF60_RS19300	COG4774	siderophore transport
CF60_RS19305	COG0187	DNA topoisomerase II activity
CF60_RS19310	COG3150	esterase
CF60_RS19315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CF60_RS19320	COG3151	Protein conserved in bacteria
CF60_RS19325	COG0494	nUDIX hydrolase
CF60_RS19330	COG1538	Outer membrane efflux protein
CF60_RS19345	COG0754	glutathionylspermidine amidase activity
CF60_RS19355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CF60_RS19360	COG2963	transposase activity
CF60_RS19365	COG2801	Transposase and inactivated derivatives
CF60_RS19375	COG3384	dioxygenase
CF60_RS19390	COG3539	Fimbrial protein
CF60_RS19395	COG3188	usher protein
CF60_RS19400	COG3121	Chaperone
CF60_RS19405	COG3539	Fimbrial protein
CF60_RS19425	COG1585	Membrane protein implicated in regulation of membrane protease activity
CF60_RS19430	COG2268	Band 7 protein
CF60_RS19450	COG3025	triphosphatase activity
CF60_RS19460	COG4991	sh3 domain protein
CF60_RS19475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CF60_RS19490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CF60_RS19495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CF60_RS19510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CF60_RS19515	COG0358	DNA primase activity
CF60_RS19520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF60_RS19535	COG2375	cellular response to nickel ion
CF60_RS19540	COG1695	Transcriptional regulator
CF60_RS19545	COG0840	transmembrane signaling receptor activity
CF60_RS19555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CF60_RS19560	COG1609	Transcriptional regulator
CF60_RS19565	COG3250	beta-galactosidase activity
CF60_RS19570	COG2731	YhcH YjgK YiaL family protein
CF60_RS19575	COG0531	amino acid
CF60_RS19585	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CF60_RS19585	COG3408	Glycogen debranching enzyme
CF60_RS19590	COG0446	pyridine nucleotide-disulphide oxidoreductase
CF60_RS19590	COG1902	pentaerythritol trinitrate reductase activity
CF60_RS19595	COG5499	transcription regulator containing HTH domain
CF60_RS19600	COG4680	protein conserved in bacteria
CF60_RS19615	COG1451	nucleotide metabolic process
CF60_RS19620	COG2949	membrane
CF60_RS19625	COG0673	inositol 2-dehydrogenase activity
CF60_RS19630	COG0861	Integral membrane protein TerC family
CF60_RS19635	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CF60_RS19645	COG2721	sulfolactate sulfo-lyase activity
CF60_RS19655	COG2271	Major facilitator Superfamily
CF60_RS19660	COG2186	Transcriptional regulator
CF60_RS19665	COG0586	Pfam SNARE associated Golgi protein
CF60_RS19675	COG1422	Protein of unknown function (DUF1090)
CF60_RS19680	COG4575	ribosome binding
CF60_RS19685	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CF60_RS19695	COG2259	Doxx family
CF60_RS19700	COG0435	Glutathione S-transferase
CF60_RS19710	COG3152	Membrane
CF60_RS19715	COG3152	Membrane
CF60_RS19720	COG0583	DNA-binding transcription factor activity
CF60_RS19725	COG1741	Belongs to the pirin family
CF60_RS19740	COG0814	amino acid
CF60_RS19745	COG1760	l-serine dehydratase
CF60_RS19750	COG0251	oxidation-reduction process
CF60_RS19755	COG1882	Formate acetyltransferase
CF60_RS19760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CF60_RS19770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF60_RS19775	COG0583	DNA-binding transcription factor activity
CF60_RS19800	COG1929	Belongs to the glycerate kinase type-1 family
CF60_RS19805	COG2084	Dehydrogenase
CF60_RS19815	COG2271	Major facilitator Superfamily
CF60_RS19820	COG2721	sulfolactate sulfo-lyase activity
CF60_RS19825	COG2002	toxin-antitoxin pair type II binding
CF60_RS19835	COG1349	DNA-binding transcription factor activity
CF60_RS19845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS19855	COG3716	PTS system mannose fructose sorbose family IID component
CF60_RS19860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS19865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CF60_RS19870	COG2222	sugar isomerase
CF60_RS19880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CF60_RS19885	COG3715	PTS system
CF60_RS19890	COG3716	PTS system mannose fructose sorbose family IID component
CF60_RS19895	COG0363	glucosamine-6-phosphate deaminase activity
CF60_RS19900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CF60_RS19920	COG2823	Periplasmic or secreted lipoprotein
CF60_RS19925	COG0701	Predicted permease
CF60_RS19930	COG0702	epimerase
CF60_RS19935	COG0693	protein deglycase activity
CF60_RS19950	COG3153	acetyltransferase
CF60_RS19955	COG3154	lipid carrier protein
CF60_RS19960	COG0826	peptidase U32
CF60_RS19965	COG0826	peptidase U32
CF60_RS19970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CF60_RS19975	COG0814	amino acid
CF60_RS19985	COG0513	Belongs to the DEAD box helicase family
CF60_RS20020	COG0195	Participates in both transcription termination and antitermination
CF60_RS20040	COG2194	sulfuric ester hydrolase activity
CF60_RS20050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CF60_RS20060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CF60_RS20065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CF60_RS20075	COG1534	Rna-binding protein
CF60_RS20080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF60_RS20085	COG2027	D-alanyl-D-alanine carboxypeptidase
CF60_RS20095	COG0697	spore germination
CF60_RS20110	COG0142	geranyltranstransferase activity
CF60_RS20115	COG3423	Transcriptional regulator
CF60_RS20125	COG5007	Belongs to the BolA IbaG family
CF60_RS20130	COG3113	response to antibiotic
CF60_RS20135	COG2854	intermembrane phospholipid transfer
CF60_RS20140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CF60_RS20145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CF60_RS20150	COG1127	ABC transporter
CF60_RS20155	COG0530	calcium, potassium:sodium antiporter activity
CF60_RS20160	COG0517	IMP dehydrogenase activity
CF60_RS20160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CF60_RS20165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CF60_RS20170	COG3117	lipopolysaccharide transmembrane transporter activity
CF60_RS20175	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CF60_RS20180	COG1137	ATPase activity
CF60_RS20185	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CF60_RS20190	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CF60_RS20205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS20210	COG0515	serine threonine protein kinase
CF60_RS20220	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CF60_RS20225	COG5002	protein histidine kinase activity
CF60_RS20225	COG2198	Histidine kinase
CF60_RS20225	COG0784	Response regulator, receiver
CF60_RS20230	COG1242	4 iron, 4 sulfur cluster binding
CF60_RS20235	COG0069	glutamate synthase activity
CF60_RS20235	COG0070	glutamate synthase
CF60_RS20235	COG0067	glutamate synthase
CF60_RS20240	COG0493	'glutamate synthase
CF60_RS20245	COG4804	nuclease activity
CF60_RS20250	COG2731	YhcH YjgK YiaL family protein
CF60_RS20280	COG3069	C4-dicarboxylate transmembrane transporter activity
CF60_RS20285	COG2969	positive regulation of protein catabolic process
CF60_RS20290	COG0625	glutathione transferase activity
CF60_RS20305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CF60_RS20310	COG3105	Protein conserved in bacteria
CF60_RS20315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF60_RS20320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CF60_RS20340	COG2732	(Barnase) inhibitor
CF60_RS20360	COG0583	DNA-binding transcription factor activity
CF60_RS20365	COG0312	modulator of DNA gyrase
CF60_RS20370	COG3164	Protein of unknown function
CF60_RS20375	COG1530	ribonuclease E activity
CF60_RS20385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CF60_RS20390	COG1792	Involved in formation and maintenance of cell shape
CF60_RS20395	COG1077	Cell shape determining protein MreB Mrl
CF60_RS20405	COG2199	diguanylate cyclase activity
CF60_RS20405	COG2200	EAL domain
CF60_RS20410	COG0604	alcohol dehydrogenase
CF60_RS20430	COG0511	ligase activity, forming carbon-carbon bonds
CF60_RS20435	COG0439	Biotin carboxylase
CF60_RS20440	COG3924	membrane
CF60_RS20445	COG4145	pantothenate transmembrane transporter activity
CF60_RS20455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CF60_RS20465	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CF60_RS20475	COG1309	transcriptional regulator
CF60_RS20480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF60_RS20505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CF60_RS20510	COG4597	amino acid ABC transporter
CF60_RS20515	COG0765	amino acid transport
CF60_RS20520	COG1126	abc transporter atp-binding protein
CF60_RS20565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CF60_RS20630	COG0789	Transcriptional regulator
CF60_RS20655	COG0551	DNA topoisomerase type I activity
CF60_RS20665	COG0758	DNA mediated transformation
CF60_RS20685	COG0569	domain protein
CF60_RS20695	COG3036	rescue of stalled ribosome
CF60_RS20700	COG0789	Transcriptional regulator
CF60_RS20740	COG0201	protein transport
CF60_RS20830	COG0089	rRNA binding
CF60_RS20905	COG2964	Protein conserved in bacteria
CF60_RS20910	COG0545	Peptidyl-prolyl cis-trans isomerase
CF60_RS20920	COG1047	Peptidyl-prolyl cis-trans
CF60_RS20925	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CF60_RS20940	COG0488	(ABC) transporter
CF60_RS20945	COG0429	hydrolase of the alpha beta-hydrolase fold
CF60_RS20955	COG3954	Phosphoribulokinase
CF60_RS20960	COG1765	OsmC-like protein
CF60_RS20970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CF60_RS20975	COG1289	transmembrane transporter activity
CF60_RS20980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CF60_RS20985	COG0512	Glutamine amidotransferase of anthranilate synthase
CF60_RS20990	COG2184	nucleotidyltransferase activity
CF60_RS21000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CF60_RS21010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CF60_RS21015	COG2146	nitrite reductase [NAD(P)H] activity
CF60_RS21020	COG2116	formate transmembrane transporter activity
CF60_RS21035	COG0626	cystathionine gamma-synthase activity
CF60_RS21050	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CF60_RS21055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CF60_RS21060	COG3457	Alanine racemase
CF60_RS21070	COG2188	Transcriptional regulator
CF60_RS21075	COG0180	Tryptophanyl-tRNA synthetase
CF60_RS21085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CF60_RS21090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CF60_RS21095	COG3266	domain, Protein
CF60_RS21110	COG4796	Type ii and iii secretion system protein
CF60_RS21125	COG3166	PFAM Fimbrial assembly family protein
CF60_RS21130	COG4972	Pilus assembly protein
CF60_RS21135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CF60_RS21140	COG0494	nUDIX hydrolase
CF60_RS21150	COG1011	Hydrolase
CF60_RS21155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CF60_RS21165	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CF60_RS21190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CF60_RS21195	COG2183	response to ionizing radiation
CF60_RS21200	COG1918	ferrous iron import across plasma membrane
CF60_RS21205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CF60_RS21215	COG5464	transposase or invertase
CF60_RS21240	COG1640	4-alpha-glucanotransferase
CF60_RS21245	COG0058	SHG alpha-glucan phosphorylase activity
CF60_RS21260	COG1690	Belongs to the RtcB family
CF60_RS21265	COG4650	regulator
CF60_RS21270	COG1349	DNA-binding transcription factor activity
CF60_RS21285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CF60_RS21310	COG3539	Fimbrial protein
CF60_RS21315	COG3188	usher protein
CF60_RS21320	COG3121	Chaperone
CF60_RS21330	COG0058	SHG alpha-glucan phosphorylase activity
CF60_RS21350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CF60_RS21355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CF60_RS21360	COG2095	MarC family integral membrane protein
CF60_RS21365	COG2610	gluconate transmembrane transporter activity
CF60_RS21370	COG3265	gluconokinase activity
CF60_RS21375	COG1609	Transcriptional regulator
CF60_RS21380	COG1741	Belongs to the pirin family
CF60_RS21385	COG0673	inositol 2-dehydrogenase activity
CF60_RS21395	COG1247	-acetyltransferase
CF60_RS21400	COG3157	Type VI secretion system effector, Hcp
CF60_RS21415	COG0405	Gamma-glutamyltransferase
CF60_RS21425	COG0584	glycerophosphoryl diester phosphodiesterase
CF60_RS21440	COG1175	transmembrane transport
CF60_RS21445	COG1653	transport
CF60_RS21455	COG0410	ABC transporter
CF60_RS21460	COG0411	ABC transporter
CF60_RS21465	COG4177	L-phenylalanine transmembrane transporter activity
CF60_RS21470	COG0559	Belongs to the binding-protein-dependent transport system permease family
CF60_RS21475	COG0683	leucine binding
CF60_RS21480	COG0456	acetyltransferase
CF60_RS21490	COG0683	leucine binding
CF60_RS21495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CF60_RS21500	COG2177	Part of the ABC transporter FtsEX involved in
CF60_RS21505	COG2884	Cell division ATP-binding protein ftsE
CF60_RS21510	COG0552	protein localization to endoplasmic reticulum
CF60_RS21515	COG0742	ribosomal rna small subunit methyltransferase
CF60_RS21520	COG3776	membrane
CF60_RS21530	COG3714	YhhN family
CF60_RS21545	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CF60_RS21560	COG0628	permease
CF60_RS21565	COG2091	lysine biosynthetic process via aminoadipic acid
CF60_RS21570	COG0747	negative chemotaxis
CF60_RS21575	COG0601	transmembrane transport
CF60_RS21580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF60_RS21600	COG3209	COG3209 Rhs family protein
CF60_RS21620	COG3209	COG3209 Rhs family protein
CF60_RS21630	COG1413	lyase activity
CF60_RS21635	COG3209	COG3209 Rhs family protein
CF60_RS21640	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CF60_RS21645	COG5433	transposase activity
CF60_RS21650	COG0842	Transport permease protein
CF60_RS21655	COG1129	ABC transporter
CF60_RS21655	COG0842	Transport permease protein
CF60_RS21660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF60_RS21690	COG2081	HI0933 family
CF60_RS21695	COG0306	phosphate transporter
CF60_RS21705	COG0589	response to stress
CF60_RS21710	COG3104	oligopeptide transport
CF60_RS21720	COG0339	signal peptide processing
CF60_RS21725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CF60_RS21730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CF60_RS21745	COG0640	Transcriptional regulator
CF60_RS21750	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CF60_RS21755	COG1393	Belongs to the ArsC family
CF60_RS21775	COG3065	identical protein binding
CF60_RS21780	COG2197	response regulator
CF60_RS21785	COG3720	iron ion transport
CF60_RS21790	COG4771	TonB-dependent receptor
CF60_RS21795	COG4558	Periplasmic binding protein
CF60_RS21805	COG3721	Heme iron utilization protein
CF60_RS21815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CF60_RS21825	COG1285	pathogenesis
CF60_RS21840	COG3247	response to pH
CF60_RS21845	COG2771	luxR family
CF60_RS21855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CF60_RS21860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CF60_RS21865	COG2207	Transcriptional regulator
CF60_RS21870	COG2207	Transcriptional regulator
CF60_RS21875	COG0076	glutamate decarboxylase activity
CF60_RS21880	COG1858	cytochrome C peroxidase
CF60_RS21890	COG2197	response regulator
CF60_RS21895	COG0583	DNA-binding transcription factor activity
CF60_RS21900	COG1295	ribonuclease BN
CF60_RS21905	COG0477	Major facilitator Superfamily
CF60_RS21910	COG2982	Protein involved in outer membrane biogenesis
CF60_RS21915	COG2200	EAL domain
CF60_RS21925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF60_RS21930	COG0612	Peptidase, M16
CF60_RS21940	COG2199	diguanylate cyclase activity
CF60_RS21940	COG2200	EAL domain
CF60_RS21945	COG3118	belongs to the thioredoxin family
CF60_RS21945	COG0457	Tetratricopeptide repeat
CF60_RS21950	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CF60_RS21955	COG1215	transferase activity, transferring glycosyl groups
CF60_RS21960	COG1215	transferase activity, transferring glycosyl groups
CF60_RS21985	COG2194	sulfuric ester hydrolase activity
CF60_RS22005	COG0814	amino acid
CF60_RS22010	COG4608	Belongs to the ABC transporter superfamily
CF60_RS22015	COG0444	Belongs to the ABC transporter superfamily
CF60_RS22020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CF60_RS22025	COG0601	transmembrane transport
CF60_RS22035	COG0747	negative chemotaxis
CF60_RS22050	COG2194	sulfuric ester hydrolase activity
CF60_RS22055	COG2223	nitrite transmembrane transporter activity
CF60_RS22060	COG5571	outer membrane autotransporter
CF60_RS22065	COG2818	Glycosylase
CF60_RS22070	COG0456	acetyltransferase
CF60_RS22075	COG0243	molybdopterin cofactor binding
CF60_RS22080	COG2885	chlorophyll binding
CF60_RS22095	COG2944	sequence-specific DNA binding
CF60_RS22100	COG1278	Cold shock
CF60_RS22110	COG2801	Transposase and inactivated derivatives
CF60_RS22115	COG2963	transposase activity
CF60_RS22135	COG3274	enterobacterial common antigen metabolic process
CF60_RS22140	COG4682	membrane
CF60_RS22145	COG4682	membrane
CF60_RS22150	COG1070	Carbohydrate kinase
CF60_RS22160	COG4213	ABC transporter substrate-binding protein
CF60_RS22170	COG4214	carbohydrate transport
CF60_RS22175	COG2207	Transcriptional regulator
CF60_RS22175	COG1609	Transcriptional regulator
CF60_RS22180	COG2992	FlgJ-related protein
CF60_RS22185	COG0366	Alpha amylase catalytic
CF60_RS22190	COG3977	Valine--pyruvate aminotransferase
CF60_RS22200	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CF60_RS22205	COG1414	Transcriptional regulator
CF60_RS22215	COG2731	YhcH YjgK YiaL family protein
CF60_RS22220	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CF60_RS22225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CF60_RS22230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CF60_RS22235	COG1070	Carbohydrate kinase
CF60_RS22240	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CF60_RS22245	COG3623	hexulose-6-phosphate isomerase
CF60_RS22250	COG0235	Class ii aldolase
CF60_RS22260	COG2211	Major facilitator Superfamily
CF60_RS22290	COG1012	belongs to the aldehyde dehydrogenase family
CF60_RS22300	COG1454	alcohol dehydrogenase
CF60_RS22305	COG3276	selenocysteine insertion sequence binding
CF60_RS22315	COG0625	glutathione transferase activity
CF60_RS22325	COG0625	glutathione transferase activity
CF60_RS22350	COG1566	PFAM secretion protein HlyD family protein
CF60_RS22360	COG2213	PTS system mannitol-specific
CF60_RS22360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CF60_RS22370	COG3722	fumarate hydratase activity
CF60_RS22390	COG5295	Hep Hag repeat protein
CF60_RS22395	COG1620	l-lactate permease
CF60_RS22400	COG2186	Transcriptional regulator
CF60_RS22410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CF60_RS22415	COG1045	serine acetyltransferase
CF60_RS22430	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CF60_RS22435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CF60_RS22450	COG4942	peptidase
CF60_RS22455	COG2861	carbohydrate metabolic process
CF60_RS22460	COG1216	Glycosyl transferase, family 2
CF60_RS22470	COG0156	8-amino-7-oxononanoate synthase activity
CF60_RS22480	COG0859	PFAM glycosyl transferase family 9
CF60_RS22485	COG0859	PFAM glycosyl transferase family 9
CF60_RS22520	COG0515	serine threonine protein kinase
CF60_RS22525	COG0438	transferase activity, transferring glycosyl groups
CF60_RS22530	COG0859	PFAM glycosyl transferase family 9
CF60_RS22535	COG1519	Transferase
CF60_RS22545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CF60_RS22565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CF60_RS22590	COG1561	YicC-like family, N-terminal region
CF60_RS22595	COG3645	SOS response
CF60_RS22610	COG0194	GDP metabolic process
CF60_RS22620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CF60_RS22625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CF60_RS22630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CF60_RS22640	COG0786	glutamate:sodium symporter activity
CF60_RS22645	COG2233	PERMEase
CF60_RS22650	COG2982	Protein involved in outer membrane biogenesis
CF60_RS22655	COG1501	Belongs to the glycosyl hydrolase 31 family
CF60_RS22660	COG2211	Major facilitator Superfamily
CF60_RS22670	COG0582	viral genome integration into host DNA
CF60_RS22740	COG2814	Major facilitator Superfamily
CF60_RS22745	COG0697	spore germination
CF60_RS22750	COG1464	Belongs to the NlpA lipoprotein family
CF60_RS22775	COG2252	PERMEase
CF60_RS22785	COG2271	Major facilitator Superfamily
CF60_RS22790	COG2271	Major facilitator Superfamily
CF60_RS22795	COG3851	Histidine kinase
CF60_RS22800	COG2197	response regulator
CF60_RS22820	COG0440	acetolactate synthase activity
CF60_RS22825	COG0028	Belongs to the TPP enzyme family
CF60_RS22850	COG2814	Major facilitator Superfamily
CF60_RS22855	COG0641	radical SAM
CF60_RS22865	COG2149	membrane
CF60_RS22870	COG3119	arylsulfatase activity
CF60_RS22875	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CF60_RS22880	COG2207	Transcriptional regulator
CF60_RS22895	COG2188	Transcriptional regulator
CF60_RS22920	COG5645	(Lipo)protein
CF60_RS22925	COG0823	Involved in the tonB-independent uptake of proteins
CF60_RS22935	COG2271	Major facilitator Superfamily
CF60_RS22945	COG0800	Aldolase
CF60_RS22950	COG3734	2-keto-3-deoxy-galactonokinase
CF60_RS22955	COG2186	Transcriptional regulator
CF60_RS22965	COG0561	phosphatase activity
CF60_RS22970	COG3753	Protein conserved in bacteria
CF60_RS22975	COG0187	DNA topoisomerase II activity
CF60_RS22985	COG0592	DNA-directed DNA polymerase activity
CF60_RS23035	COG0814	amino acid
CF60_RS23050	COG2091	lysine biosynthetic process via aminoadipic acid
CF60_RS23055	COG0431	NADPH-dependent FMN reductase
CF60_RS23060	COG2252	PERMEase
CF60_RS23065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CF60_RS23085	COG0704	Plays a role in the regulation of phosphate uptake
CF60_RS23090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CF60_RS23095	COG0581	inorganic phosphate transmembrane transporter activity
CF60_RS23100	COG0573	inorganic phosphate transmembrane transporter activity
CF60_RS23105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CF60_RS23130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CF60_RS23180	COG3312	ion transport
CF60_RS23195	COG0716	FMN binding
CF60_RS23200	COG1522	sequence-specific DNA binding
CF60_RS23230	COG1129	ABC transporter
CF60_RS23235	COG1172	Belongs to the binding-protein-dependent transport system permease family
CF60_RS23240	COG1879	ABC-type sugar transport system periplasmic component
CF60_RS23245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CF60_RS23255	COG0477	Major facilitator Superfamily
CF60_RS23260	COG2186	Transcriptional regulator
CF60_RS23310	COG3085	chromosome segregation
CF60_RS23315	COG0606	chelatase, subunit chli
CF60_RS23330	COG3978	acetolactate synthase activity
CF60_RS23335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CF60_RS23345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CF60_RS23350	COG0583	DNA-binding transcription factor activity
CF60_RS23360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CF60_RS23365	COG3692	DNA binding
CF60_RS23370	COG0210	DNA helicase
CF60_RS23385	COG3118	belongs to the thioredoxin family
CF60_RS23395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CF60_RS23410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CF60_RS23415	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CF60_RS23420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CF60_RS23425	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CF60_RS23430	COG0456	acetyltransferase
CF60_RS23435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CF60_RS23440	COG2244	polysaccharide biosynthetic process
CF60_RS23460	COG1113	amino acid transport
CF60_RS23485	COG0641	radical SAM
CF60_RS23490	COG3119	arylsulfatase activity
CF60_RS23495	COG3071	HemY protein
CF60_RS23500	COG2959	enzyme of heme biosynthesis
CF60_RS23520	COG1587	Uroporphyrinogen-III synthase
CF60_RS23530	COG3072	Adenylate cyclase
CF60_RS23540	COG5567	small periplasmic lipoprotein
CF60_RS23550	COG3159	Protein conserved in bacteria
CF60_RS23560	COG1011	Hydrolase
CF60_RS23565	COG0210	DNA helicase
CF60_RS23570	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CF60_RS23575	COG3698	Phosphodiester glycosidase
CF60_RS23585	COG0598	Magnesium transport protein CorA
CF60_RS23600	COG2962	Rard protein
CF60_RS23605	COG2050	protein possibly involved in aromatic compounds catabolism
CF60_RS23610	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CF60_RS23615	COG0514	ATP-dependent DNA helicase (RecQ)
CF60_RS23620	COG1280	lysine exporter protein (LysE YggA)
CF60_RS23625	COG1280	lysine exporter protein (LysE YggA)
CF60_RS23630	COG2267	carboxylic ester hydrolase activity
CF60_RS23635	COG0561	phosphatase activity
CF60_RS23640	COG0697	spore germination
CF60_RS23645	COG0583	DNA-binding transcription factor activity
CF60_RS23650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CF60_RS23665	COG3157	Type VI secretion system effector, Hcp
CF60_RS23670	COG0412	Dienelactone hydrolase
CF60_RS23675	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CF60_RS23680	COG1322	Protein conserved in bacteria
CF60_RS23690	COG3165	ubiquinone biosynthetic process from chorismate
CF60_RS23700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF60_RS23705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CF60_RS23710	COG0805	protein transport
CF60_RS23720	COG0250	Participates in transcription elongation, termination and antitermination
CF60_RS23725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CF60_RS23730	COG0543	2 iron, 2 sulfur cluster binding
CF60_RS23750	COG1739	Uncharacterized protein family UPF0029
CF60_RS23755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CF60_RS23760	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CF60_RS23935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CF60_RS23945	COG1454	alcohol dehydrogenase
CF60_RS23995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CF60_RS24000	COG2207	Transcriptional regulator
CF60_RS24030	COG2801	Transposase and inactivated derivatives
CF60_RS24090	COG3708	Transcriptional regulator
CF60_RS24090	COG2207	Transcriptional regulator
CF60_RS24155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CF60_RS24170	COG0741	lytic transglycosylase activity
CF60_RS24210	COG0527	aspartate kinase activity
CF60_RS24220	COG1187	pseudouridine synthase activity
CF60_RS24310	COG2271	Major facilitator Superfamily
CF60_RS24315	COG1609	Transcriptional regulator
CF60_RS24390	COG1487	ribonuclease activity
CF60_RS24410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CF60_RS24460	COG2805	Type II/IV secretion system protein
CF60_RS24505	COG2801	Transposase and inactivated derivatives
CF60_RS24555	COG4571	Outer membrane protease
CF60_RS24560	COG2207	Transcriptional regulator
CF60_RS24590	COG0567	Dehydrogenase, E1 component
CF60_RS24600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CF60_RS24675	COG2814	Major facilitator Superfamily
CF60_RS24685	COG1464	Belongs to the NlpA lipoprotein family
CF60_RS24810	COG3209	COG3209 Rhs family protein
CF60_RS24815	COG5433	transposase activity
CF60_RS24870	COG1196	nuclear chromosome segregation
CF60_RS24915	COG4917	ethanolamine utilization protein
CF60_RS24925	COG3071	HemY protein
CF60_RS24955	COG0527	aspartate kinase activity