locus-tag	class	description
UM146_RS00025	COG1126	abc transporter atp-binding protein
UM146_RS00030	COG0765	amino acid transport
UM146_RS00035	COG4597	amino acid ABC transporter
UM146_RS00040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS00060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UM146_RS00065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UM146_RS00070	COG1309	transcriptional regulator
UM146_RS00080	COG2189	Belongs to the N(4) N(6)-methyltransferase family
UM146_RS00090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UM146_RS00100	COG4145	pantothenate transmembrane transporter activity
UM146_RS00105	COG3924	membrane
UM146_RS00110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS00115	COG1349	DNA-binding transcription factor activity
UM146_RS00125	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS00130	COG1129	ABC transporter
UM146_RS00135	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS00150	COG0439	Biotin carboxylase
UM146_RS00155	COG0511	ligase activity, forming carbon-carbon bonds
UM146_RS00175	COG0604	alcohol dehydrogenase
UM146_RS00180	COG2200	EAL domain
UM146_RS00180	COG2199	diguanylate cyclase activity
UM146_RS00190	COG1077	Cell shape determining protein MreB Mrl
UM146_RS00195	COG1792	Involved in formation and maintenance of cell shape
UM146_RS00200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
UM146_RS00210	COG1530	ribonuclease E activity
UM146_RS00215	COG3164	Protein of unknown function
UM146_RS00220	COG0312	modulator of DNA gyrase
UM146_RS00225	COG0583	DNA-binding transcription factor activity
UM146_RS00245	COG2732	(Barnase) inhibitor
UM146_RS00265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UM146_RS00270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UM146_RS00275	COG3105	Protein conserved in bacteria
UM146_RS00280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
UM146_RS00295	COG0625	glutathione transferase activity
UM146_RS00300	COG2969	positive regulation of protein catabolic process
UM146_RS00330	COG2731	YhcH YjgK YiaL family protein
UM146_RS00335	COG0493	'glutamate synthase
UM146_RS00340	COG0070	glutamate synthase
UM146_RS00340	COG0069	glutamate synthase activity
UM146_RS00340	COG0067	glutamate synthase
UM146_RS00345	COG0067	glutamate synthase
UM146_RS00345	COG0069	glutamate synthase activity
UM146_RS00345	COG0070	glutamate synthase
UM146_RS00350	COG1242	4 iron, 4 sulfur cluster binding
UM146_RS00355	COG5002	protein histidine kinase activity
UM146_RS00355	COG2198	Histidine kinase
UM146_RS00355	COG0784	Response regulator, receiver
UM146_RS00360	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
UM146_RS00370	COG0515	serine threonine protein kinase
UM146_RS00375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS00390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UM146_RS00395	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UM146_RS00400	COG1137	ATPase activity
UM146_RS00405	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
UM146_RS00410	COG3117	lipopolysaccharide transmembrane transporter activity
UM146_RS00415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
UM146_RS00420	COG0517	IMP dehydrogenase activity
UM146_RS00420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
UM146_RS00425	COG0530	calcium, potassium:sodium antiporter activity
UM146_RS00430	COG1127	ABC transporter
UM146_RS00435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UM146_RS00440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UM146_RS00445	COG2854	intermembrane phospholipid transfer
UM146_RS00450	COG3113	response to antibiotic
UM146_RS00455	COG5007	Belongs to the BolA IbaG family
UM146_RS00465	COG3423	Transcriptional regulator
UM146_RS00470	COG0142	geranyltranstransferase activity
UM146_RS00485	COG0697	spore germination
UM146_RS00495	COG2027	D-alanyl-D-alanine carboxypeptidase
UM146_RS00500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UM146_RS00505	COG1534	Rna-binding protein
UM146_RS00515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UM146_RS00520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UM146_RS00530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UM146_RS00540	COG2194	sulfuric ester hydrolase activity
UM146_RS00560	COG0195	Participates in both transcription termination and antitermination
UM146_RS00595	COG0513	Belongs to the DEAD box helicase family
UM146_RS00605	COG0814	amino acid
UM146_RS00610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UM146_RS00615	COG0826	peptidase U32
UM146_RS00620	COG0826	peptidase U32
UM146_RS00625	COG3154	lipid carrier protein
UM146_RS00630	COG3153	acetyltransferase
UM146_RS00645	COG0693	protein deglycase activity
UM146_RS00650	COG0702	epimerase
UM146_RS00655	COG0701	Predicted permease
UM146_RS00660	COG2823	Periplasmic or secreted lipoprotein
UM146_RS00675	COG3107	peptidoglycan biosynthetic process
UM146_RS00680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UM146_RS00685	COG0363	glucosamine-6-phosphate deaminase activity
UM146_RS00690	COG3716	PTS system mannose fructose sorbose family IID component
UM146_RS00695	COG3715	PTS system
UM146_RS00700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS00710	COG2222	sugar isomerase
UM146_RS00715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UM146_RS00720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS00725	COG3716	PTS system mannose fructose sorbose family IID component
UM146_RS00735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS00745	COG1349	DNA-binding transcription factor activity
UM146_RS00750	COG2721	sulfolactate sulfo-lyase activity
UM146_RS00755	COG2271	Major facilitator Superfamily
UM146_RS00765	COG2084	Dehydrogenase
UM146_RS00770	COG1929	Belongs to the glycerate kinase type-1 family
UM146_RS00780	COG0583	DNA-binding transcription factor activity
UM146_RS00785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UM146_RS00795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UM146_RS00800	COG1882	Formate acetyltransferase
UM146_RS00805	COG0251	oxidation-reduction process
UM146_RS00810	COG1760	l-serine dehydratase
UM146_RS00815	COG0814	amino acid
UM146_RS00830	COG1741	Belongs to the pirin family
UM146_RS00835	COG0583	DNA-binding transcription factor activity
UM146_RS00840	COG3152	Membrane
UM146_RS00845	COG0435	Glutathione S-transferase
UM146_RS00850	COG2259	Doxx family
UM146_RS00860	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
UM146_RS00865	COG4575	ribosome binding
UM146_RS00870	COG1422	Protein of unknown function (DUF1090)
UM146_RS00880	COG0586	Pfam SNARE associated Golgi protein
UM146_RS00885	COG2186	Transcriptional regulator
UM146_RS00890	COG2271	Major facilitator Superfamily
UM146_RS00900	COG2721	sulfolactate sulfo-lyase activity
UM146_RS00915	COG0861	Integral membrane protein TerC family
UM146_RS00920	COG0673	inositol 2-dehydrogenase activity
UM146_RS00925	COG2949	membrane
UM146_RS00930	COG1451	nucleotide metabolic process
UM146_RS00940	COG0446	pyridine nucleotide-disulphide oxidoreductase
UM146_RS00940	COG1902	pentaerythritol trinitrate reductase activity
UM146_RS00945	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
UM146_RS00945	COG3408	Glycogen debranching enzyme
UM146_RS00955	COG0531	amino acid
UM146_RS00960	COG2731	YhcH YjgK YiaL family protein
UM146_RS00965	COG3250	beta-galactosidase activity
UM146_RS00970	COG1609	Transcriptional regulator
UM146_RS00975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UM146_RS00985	COG0840	transmembrane signaling receptor activity
UM146_RS00990	COG1695	Transcriptional regulator
UM146_RS00995	COG2375	cellular response to nickel ion
UM146_RS01010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UM146_RS01015	COG0358	DNA primase activity
UM146_RS01020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UM146_RS01035	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
UM146_RS01055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UM146_RS01070	COG4991	sh3 domain protein
UM146_RS01080	COG3025	triphosphatase activity
UM146_RS01100	COG2268	Band 7 protein
UM146_RS01105	COG1585	Membrane protein implicated in regulation of membrane protease activity
UM146_RS01125	COG3539	Fimbrial protein
UM146_RS01130	COG3121	Chaperone
UM146_RS01135	COG3188	usher protein
UM146_RS01140	COG3539	Fimbrial protein
UM146_RS01155	COG3384	dioxygenase
UM146_RS01165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UM146_RS01175	COG0754	glutathionylspermidine amidase activity
UM146_RS01190	COG1538	Outer membrane efflux protein
UM146_RS01195	COG0494	nUDIX hydrolase
UM146_RS01200	COG3151	Protein conserved in bacteria
UM146_RS01205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UM146_RS01210	COG3150	esterase
UM146_RS01215	COG0187	DNA topoisomerase II activity
UM146_RS01220	COG4774	siderophore transport
UM146_RS01225	COG1120	ATPase activity
UM146_RS01230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM146_RS01235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM146_RS01245	COG1737	Transcriptional regulator
UM146_RS01250	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
UM146_RS01255	COG2249	NAD(P)H dehydrogenase (quinone) activity
UM146_RS01275	COG0642	Histidine kinase
UM146_RS01280	COG0745	RESPONSE REGULATOR receiver
UM146_RS01290	COG3111	PFAM Bacterial OB fold (BOF) protein
UM146_RS01295	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
UM146_RS01300	COG4166	transmembrane transport
UM146_RS01305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UM146_RS01310	COG0204	Acyl-transferase
UM146_RS01315	COG2132	Multicopper oxidase
UM146_RS01335	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
UM146_RS01340	COG1063	alcohol dehydrogenase
UM146_RS01345	COG0246	Mannitol dehydrogenase
UM146_RS01350	COG2186	Transcriptional regulator
UM146_RS01355	COG1032	radical SAM domain protein
UM146_RS01360	COG4238	major outer membrane lipoprotein
UM146_RS01370	COG0656	L-ascorbic acid biosynthetic process
UM146_RS01375	COG1979	alcohol dehydrogenase
UM146_RS01385	COG2207	Transcriptional regulator
UM146_RS01390	COG0586	Pfam SNARE associated Golgi protein
UM146_RS01395	COG0626	cystathionine gamma-synthase activity
UM146_RS01405	COG0811	peptide transport
UM146_RS01410	COG0848	biopolymer transport protein
UM146_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS01425	COG0667	Aldo Keto reductase
UM146_RS01445	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
UM146_RS01450	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS01455	COG5557	Pfam Polysulphide reductase, NrfD
UM146_RS01460	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
UM146_RS01465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
UM146_RS01470	COG1773	rubredoxin
UM146_RS01475	COG0375	protein maturation
UM146_RS01480	COG0298	carbon dioxide binding
UM146_RS01485	COG0625	glutathione transferase activity
UM146_RS01490	COG0754	glutathionylspermidine amidase activity
UM146_RS01495	COG0306	phosphate transporter
UM146_RS01500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UM146_RS01505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UM146_RS01510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UM146_RS01515	COG2244	polysaccharide biosynthetic process
UM146_RS01525	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
UM146_RS01530	COG0795	lipopolysaccharide-transporting ATPase activity
UM146_RS01545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UM146_RS01555	COG0318	PFAM AMP-dependent synthetase and ligase
UM146_RS01560	COG0456	acetyltransferase
UM146_RS01565	COG2186	Transcriptional regulator
UM146_RS01570	COG0277	FAD linked oxidase domain protein
UM146_RS01575	COG0277	FAD linked oxidase domain protein
UM146_RS01580	COG0247	lactate metabolic process
UM146_RS01585	COG3193	protein, possibly involved in utilization of glycolate and propanediol
UM146_RS01590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
UM146_RS01595	COG1620	l-lactate permease
UM146_RS01605	COG3064	Membrane
UM146_RS01620	COG3031	protein transport across the cell outer membrane
UM146_RS01630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UM146_RS01635	COG1459	type II secretion system
UM146_RS01640	COG2165	general secretion pathway protein
UM146_RS01670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
UM146_RS01755	COG1811	Na channel or pump
UM146_RS01760	COG1982	Orn Lys Arg decarboxylase major
UM146_RS01765	COG2211	Major facilitator Superfamily
UM146_RS01780	COG1194	a g-specific adenine glycosylase
UM146_RS01790	COG3171	Protein conserved in bacteria
UM146_RS01805	COG0252	asparaginase activity
UM146_RS01815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UM146_RS01820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UM146_RS01830	COG0762	integral membrane protein
UM146_RS01835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UM146_RS01840	COG2805	Type II/IV secretion system protein
UM146_RS01855	COG0189	ligase activity
UM146_RS01860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UM146_RS01865	COG2356	endonuclease I
UM146_RS01875	COG2814	Major facilitator Superfamily
UM146_RS01900	COG1166	arginine decarboxylase activity
UM146_RS01915	COG0501	Belongs to the peptidase M48B family
UM146_RS01920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UM146_RS01925	COG0330	HflC and HflK could
UM146_RS01930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS01935	COG2213	PTS system mannitol-specific
UM146_RS01940	COG1063	alcohol dehydrogenase
UM146_RS01945	COG1494	fructose-1,6-bisphosphatase
UM146_RS01955	COG1072	(Pantothenic acid kinase))
UM146_RS01960	COG1122	ATPase activity
UM146_RS01995	COG0191	fructose-bisphosphate aldolase activity
UM146_RS02000	COG0668	transmembrane transport
UM146_RS02005	COG1279	arginine transmembrane transporter activity
UM146_RS02010	COG2968	Membrane
UM146_RS02015	COG0583	DNA-binding transcription factor activity
UM146_RS02020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UM146_RS02020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UM146_RS02040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UM146_RS02045	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UM146_RS02060	COG0006	proline dipeptidase activity
UM146_RS02065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UM146_RS02070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UM146_RS02090	COG2723	6-phospho-beta-galactosidase activity
UM146_RS02100	COG1272	protein, Hemolysin III
UM146_RS02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
UM146_RS02120	COG0716	FMN binding
UM146_RS02130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UM146_RS02135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UM146_RS02145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UM146_RS02160	COG2233	PERMEase
UM146_RS02170	COG0493	'glutamate synthase
UM146_RS02170	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS02175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS02180	COG2252	PERMEase
UM146_RS02185	COG0402	S-adenosylhomocysteine deaminase activity
UM146_RS02190	COG2233	PERMEase
UM146_RS02195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UM146_RS02195	COG2080	2 iron, 2 sulfur cluster binding
UM146_RS02200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
UM146_RS02205	COG0402	S-adenosylhomocysteine deaminase activity
UM146_RS02210	COG0493	'glutamate synthase
UM146_RS02210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS02215	COG2068	MobA-Related Protein
UM146_RS02220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UM146_RS02225	COG3608	succinylglutamate desuccinylase aspartoacylase
UM146_RS02225	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
UM146_RS02230	COG0549	Belongs to the carbamate kinase family
UM146_RS02240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UM146_RS02245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UM146_RS02250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UM146_RS02255	COG3829	transcription factor binding
UM146_RS02260	COG2080	2 iron, 2 sulfur cluster binding
UM146_RS02265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
UM146_RS02270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UM146_RS02275	COG4942	peptidase
UM146_RS02285	COG0814	amino acid
UM146_RS02290	COG0183	Belongs to the thiolase family
UM146_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS02305	COG2814	Major facilitator Superfamily
UM146_RS02310	COG1794	racemase activity, acting on amino acids and derivatives
UM146_RS02315	COG0583	DNA-binding transcription factor activity
UM146_RS02325	COG1609	Transcriptional regulator
UM146_RS02340	COG0667	Aldo Keto reductase
UM146_RS02350	COG0861	Integral membrane protein TerC family
UM146_RS02375	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
UM146_RS02390	COG2165	general secretion pathway protein
UM146_RS02395	COG4795	General secretion pathway protein
UM146_RS02405	COG4967	type IV pilus modification protein PilV
UM146_RS02410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
UM146_RS02415	COG1025	Belongs to the peptidase M16 family
UM146_RS02420	COG1074	ATP-dependent DNA helicase activity
UM146_RS02425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UM146_RS02430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UM146_RS02430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
UM146_RS02435	COG0860	N-Acetylmuramoyl-L-alanine amidase
UM146_RS02445	COG1263	PTS System
UM146_RS02445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS02555	COG2885	chlorophyll binding
UM146_RS02595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
UM146_RS02600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UM146_RS02605	COG2166	iron-sulfur cluster assembly
UM146_RS02610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UM146_RS02620	COG0583	DNA-binding transcription factor activity
UM146_RS02625	COG2363	Small membrane protein
UM146_RS02635	COG1349	DNA-binding transcription factor activity
UM146_RS02645	COG1070	Carbohydrate kinase
UM146_RS02655	COG0738	Major facilitator superfamily
UM146_RS02660	COG0235	Class ii aldolase
UM146_RS02665	COG1454	alcohol dehydrogenase
UM146_RS02675	COG1760	l-serine dehydratase
UM146_RS02680	COG0814	amino acid
UM146_RS02685	COG1611	Belongs to the LOG family
UM146_RS02705	COG3098	single-species biofilm formation
UM146_RS02710	COG0564	pseudouridine synthase activity
UM146_RS02715	COG0716	FMN binding
UM146_RS02720	COG2271	Major facilitator Superfamily
UM146_RS02725	COG4948	Mandelate Racemase Muconate Lactonizing
UM146_RS02730	COG4948	Mandelate Racemase Muconate Lactonizing
UM146_RS02735	COG2205	protein histidine kinase activity
UM146_RS02735	COG3437	response regulator, receiver
UM146_RS02735	COG3850	Histidine kinase
UM146_RS02735	COG4999	Histidine kinase
UM146_RS02745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UM146_RS02750	COG2336	PFAM SpoVT AbrB
UM146_RS02755	COG2337	Toxic component of a toxin-antitoxin (TA) module
UM146_RS02760	COG3956	TIGRFAM MazG family protein
UM146_RS02775	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UM146_RS02785	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UM146_RS02795	COG0602	queuosine metabolic process
UM146_RS02805	COG1070	Carbohydrate kinase
UM146_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS02820	COG0277	FAD linked oxidase domain protein
UM146_RS02825	COG0477	Major facilitator Superfamily
UM146_RS02835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UM146_RS02840	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
UM146_RS02845	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
UM146_RS02850	COG0644	oxidoreductase
UM146_RS02855	COG0720	synthase
UM146_RS02880	COG2234	aminopeptidase activity
UM146_RS02935	COG1388	LysM domain
UM146_RS02935	COG4942	peptidase
UM146_RS02940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UM146_RS02955	COG2610	gluconate transmembrane transporter activity
UM146_RS02960	COG3622	Belongs to the hyi family
UM146_RS02965	COG0235	Class ii aldolase
UM146_RS02970	COG3395	kinase activity
UM146_RS02975	COG2084	Dehydrogenase
UM146_RS02980	COG1349	DNA-binding transcription factor activity
UM146_RS02985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UM146_RS03015	COG3604	Transcriptional regulator
UM146_RS03020	COG0309	Hydrogenase expression formation protein (HypE)
UM146_RS03025	COG0409	Hydrogenase expression formation protein
UM146_RS03030	COG0298	carbon dioxide binding
UM146_RS03035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
UM146_RS03040	COG0375	protein maturation
UM146_RS03050	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS03055	COG0651	ATP synthesis coupled electron transport
UM146_RS03060	COG0650	Formate hydrogenlyase subunit 4
UM146_RS03065	COG3261	NADH dehydrogenase
UM146_RS03065	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
UM146_RS03070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UM146_RS03075	COG3260	NADH ubiquinone oxidoreductase 20
UM146_RS03085	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
UM146_RS03090	COG5499	transcription regulator containing HTH domain
UM146_RS03095	COG2723	6-phospho-beta-galactosidase activity
UM146_RS03100	COG1263	PTS System
UM146_RS03100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS03105	COG1609	Transcriptional regulator
UM146_RS03110	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS03115	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
UM146_RS03135	COG0517	IMP dehydrogenase activity
UM146_RS03135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
UM146_RS03140	COG1349	DNA-binding transcription factor activity
UM146_RS03145	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS03150	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS03160	COG3732	PTS system glucitol sorbitol-specific
UM146_RS03165	COG3730	PTS system glucitol sorbitol-specific
UM146_RS03170	COG2951	lytic endotransglycosylase activity
UM146_RS03175	COG1546	Belongs to the CinA family
UM146_RS03200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
UM146_RS03225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UM146_RS03230	COG1238	metal cluster binding
UM146_RS03255	COG2814	Major facilitator Superfamily
UM146_RS03260	COG1566	PFAM secretion protein HlyD family protein
UM146_RS03265	COG1846	Transcriptional regulator
UM146_RS03275	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
UM146_RS03280	COG2814	Major facilitator Superfamily
UM146_RS03285	COG2113	Glycine betaine
UM146_RS03290	COG4176	ABC-type proline glycine betaine transport system permease component
UM146_RS03295	COG4175	Glycine betaine
UM146_RS03300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UM146_RS03305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UM146_RS03315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
UM146_RS03320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UM146_RS03330	COG4575	ribosome binding
UM146_RS03345	COG2916	Histone family protein nucleoid-structuring protein H-NS
UM146_RS03355	COG0640	Transcriptional regulator
UM146_RS03360	COG0401	homolog of Blt101
UM146_RS03365	COG1652	LysM domain
UM146_RS03370	COG1802	Transcriptional regulator
UM146_RS03375	COG1113	amino acid transport
UM146_RS03380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UM146_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
UM146_RS03390	COG0579	oxidoreductase
UM146_RS03420	COG0582	viral genome integration into host DNA
UM146_RS03425	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
UM146_RS03430	COG5532	Uncharacterized conserved protein (DUF2303)
UM146_RS03450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UM146_RS03455	COG4197	protein conserved in bacteria, prophage-related
UM146_RS03480	COG4725	Belongs to the MT-A70-like family
UM146_RS03490	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
UM146_RS03500	COG1403	HNH endonuclease
UM146_RS03505	COG0484	heat shock protein binding
UM146_RS03550	COG4626	Terminase
UM146_RS03550	COG1802	Transcriptional regulator
UM146_RS03560	COG4695	Portal protein
UM146_RS03605	COG4386	tail sheath protein
UM146_RS03625	COG4228	DNA circulation
UM146_RS03645	COG3299	homolog of phage Mu protein gp47
UM146_RS03650	COG3778	Protein conserved in bacteria
UM146_RS03665	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
UM146_RS03680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UM146_RS03720	COG2867	negative regulation of translational initiation
UM146_RS03730	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UM146_RS03735	COG0497	DNA recombination
UM146_RS03750	COG4536	flavin adenine dinucleotide binding
UM146_RS03755	COG4137	Cytochrome C assembly protein
UM146_RS03760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UM146_RS03785	COG2885	chlorophyll binding
UM146_RS03790	COG2199	diguanylate cyclase activity
UM146_RS03805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UM146_RS03810	COG0287	Prephenate dehydrogenase
UM146_RS03810	COG1605	Chorismate mutase
UM146_RS03815	COG1605	Chorismate mutase
UM146_RS03815	COG0077	Prephenate dehydratase
UM146_RS03820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UM146_RS03830	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UM146_RS03835	COG0564	pseudouridine synthase activity
UM146_RS03845	COG0542	response to heat
UM146_RS03880	COG2801	Transposase and inactivated derivatives
UM146_RS03900	COG0477	Major facilitator Superfamily
UM146_RS03905	COG5544	Lipoprotein
UM146_RS03910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UM146_RS03915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM146_RS03915	COG0045	succinate-CoA ligase (ADP-forming) activity
UM146_RS03915	COG1042	CoA-binding domain protein
UM146_RS03920	COG3148	PFAM DTW domain containing protein
UM146_RS03925	COG3118	belongs to the thioredoxin family
UM146_RS03935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UM146_RS03955	COG0583	DNA-binding transcription factor activity
UM146_RS03960	COG0513	Belongs to the DEAD box helicase family
UM146_RS03970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
UM146_RS03980	COG1595	DNA-templated transcription, initiation
UM146_RS03985	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
UM146_RS03990	COG3026	antisigma factor binding
UM146_RS03995	COG3086	response to oxidative stress
UM146_RS04005	COG0681	Belongs to the peptidase S26 family
UM146_RS04025	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
UM146_RS04045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS04050	COG1737	Transcriptional regulator
UM146_RS04055	COG0560	Phosphoserine phosphatase
UM146_RS04060	COG0590	tRNA wobble adenosine to inosine editing
UM146_RS04075	COG2205	protein histidine kinase activity
UM146_RS04080	COG3170	Tfp pilus assembly protein FimV
UM146_RS04085	COG2204	response regulator
UM146_RS04090	COG0347	Belongs to the P(II) protein family
UM146_RS04095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UM146_RS04095	COG1017	nitric oxide dioxygenase activity
UM146_RS04105	COG1940	carbohydrate kinase activity
UM146_RS04110	COG0457	Tetratricopeptide repeat
UM146_RS04115	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS04120	COG1129	ABC transporter
UM146_RS04125	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS04130	COG1063	alcohol dehydrogenase
UM146_RS04135	COG2017	converts alpha-aldose to the beta-anomer
UM146_RS04140	COG2259	Doxx family
UM146_RS04145	COG2814	Major facilitator Superfamily
UM146_RS04155	COG1073	alpha beta
UM146_RS04160	COG0483	inositol monophosphate 1-phosphatase activity
UM146_RS04180	COG0822	iron-sulfur transferase activity
UM146_RS04200	COG0633	Ferredoxin
UM146_RS04205	COG2975	iron-sulfur cluster assembly
UM146_RS04220	COG2897	thiosulfate sulfurtransferase activity
UM146_RS04225	COG2373	Large extracellular alpha-helical protein
UM146_RS04260	COG2976	Protein conserved in bacteria
UM146_RS04275	COG1645	bacterial-type flagellum-dependent swarming motility
UM146_RS04300	COG0517	IMP dehydrogenase activity
UM146_RS04300	COG0516	GMP reductase activity
UM146_RS04315	COG3133	Outer membrane lipoprotein
UM146_RS04330	COG2200	EAL domain
UM146_RS04335	COG0248	Ppx GppA phosphatase
UM146_RS04340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
UM146_RS04345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UM146_RS04360	COG2233	PERMEase
UM146_RS04370	COG1393	Belongs to the ArsC family
UM146_RS04375	COG4783	chaperone-mediated protein folding
UM146_RS04380	COG0628	permease
UM146_RS04385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UM146_RS04390	COG2716	regulation of RNA biosynthetic process
UM146_RS04400	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
UM146_RS04415	COG2321	neutral zinc metallopeptidase
UM146_RS04425	COG0400	carboxylic ester hydrolase activity
UM146_RS04440	COG1393	Belongs to the ArsC family
UM146_RS04450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UM146_RS04460	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS04460	COG0493	'glutamate synthase
UM146_RS04470	COG5342	invasion associated locus B
UM146_RS04475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UM146_RS04480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UM146_RS04485	COG0281	malic enzyme
UM146_RS04485	COG0280	phosphate acetyltransferase
UM146_RS04490	COG4810	utilization protein
UM146_RS04495	COG4917	ethanolamine utilization protein
UM146_RS04500	COG4766	ethanolamine catabolic process
UM146_RS04505	COG4812	Cobalamin adenosyltransferase
UM146_RS04510	COG0280	phosphate acetyltransferase
UM146_RS04515	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
UM146_RS04520	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
UM146_RS04525	COG1012	belongs to the aldehyde dehydrogenase family
UM146_RS04530	COG4820	ethanolamine utilization protein (EutJ)
UM146_RS04535	COG1454	alcohol dehydrogenase
UM146_RS04540	COG3192	ethanolamine utilization protein
UM146_RS04545	COG4819	ethanolamine utilization protein
UM146_RS04550	COG4303	Ethanolamine ammonia lyase large subunit
UM146_RS04560	COG4816	utilization protein
UM146_RS04565	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
UM146_RS04570	COG2207	Transcriptional regulator
UM146_RS04580	COG0860	N-Acetylmuramoyl-L-alanine amidase
UM146_RS04600	COG2837	iron assimilation
UM146_RS04615	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS04620	COG4150	thiosulfate binding
UM146_RS04625	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
UM146_RS04630	COG4208	sulfate ABC transporter
UM146_RS04635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
UM146_RS04640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UM146_RS04655	COG2190	(PTS) system
UM146_RS04660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UM146_RS04665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS04670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UM146_RS04690	COG3530	Putative quorum-sensing-regulated virulence factor
UM146_RS04695	COG0385	Bile acid
UM146_RS04700	COG0583	DNA-binding transcription factor activity
UM146_RS04710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
UM146_RS04715	COG2211	Major facilitator Superfamily
UM146_RS04725	COG0583	DNA-binding transcription factor activity
UM146_RS04755	COG3415	Transposase
UM146_RS04760	COG3415	Transposase
UM146_RS04775	COG2199	diguanylate cyclase activity
UM146_RS04775	COG2200	EAL domain
UM146_RS04810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS04815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS04820	COG0006	proline dipeptidase activity
UM146_RS04825	COG1363	Peptidase, m42
UM146_RS04830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UM146_RS04830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS04830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS04835	COG2207	Transcriptional regulator
UM146_RS04840	COG3279	Response regulator of the LytR AlgR family
UM146_RS04845	COG3275	phosphorelay sensor kinase activity
UM146_RS04850	COG0436	Aminotransferase
UM146_RS04855	COG1560	Kdo2-lipid A biosynthetic process
UM146_RS04885	COG0028	Belongs to the TPP enzyme family
UM146_RS04890	COG0679	Auxin Efflux Carrier
UM146_RS04895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UM146_RS04900	COG2205	protein histidine kinase activity
UM146_RS04900	COG2198	Histidine kinase
UM146_RS04900	COG0784	Response regulator, receiver
UM146_RS04900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS04905	COG2197	response regulator
UM146_RS04910	COG1566	PFAM secretion protein HlyD family protein
UM146_RS04915	COG0477	Major facilitator Superfamily
UM146_RS04925	COG2610	gluconate transmembrane transporter activity
UM146_RS04930	COG0583	DNA-binding transcription factor activity
UM146_RS05130	COG3646	Phage regulatory protein
UM146_RS05145	COG1783	phage Terminase large subunit
UM146_RS05250	COG0582	viral genome integration into host DNA
UM146_RS05260	COG2116	formate transmembrane transporter activity
UM146_RS05270	COG2067	long-chain fatty acid transport protein
UM146_RS05275	COG3691	Protein conserved in bacteria
UM146_RS05290	COG2062	phosphohistidine phosphatase, SixA
UM146_RS05295	COG3539	Fimbrial protein
UM146_RS05300	COG3188	usher protein
UM146_RS05305	COG3121	Chaperone
UM146_RS05310	COG3539	Fimbrial protein
UM146_RS05315	COG3539	Fimbrial protein
UM146_RS05320	COG3539	Fimbrial protein
UM146_RS05355	COG0730	response to heat
UM146_RS05360	COG3101	peptidyl-lysine hydroxylation
UM146_RS05375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UM146_RS05380	COG2814	Major facilitator Superfamily
UM146_RS05395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UM146_RS05405	COG0586	Pfam SNARE associated Golgi protein
UM146_RS05415	COG0285	dihydrofolate synthase activity
UM146_RS05420	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
UM146_RS05425	COG1286	toxin biosynthetic process
UM146_RS05430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UM146_RS05435	COG0163	prenyltransferase activity
UM146_RS05440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS05445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS05450	COG4215	(ABC) transporter
UM146_RS05455	COG4160	amino acid transport
UM146_RS05460	COG4598	ABC transporter
UM146_RS05465	COG5464	transposase or invertase
UM146_RS05470	COG1090	epimerase
UM146_RS05475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UM146_RS05480	COG0625	glutathione transferase activity
UM146_RS05485	COG0625	glutathione transferase activity
UM146_RS05490	COG0622	Phosphoesterase
UM146_RS05495	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
UM146_RS05500	COG1288	antiporter activity
UM146_RS05505	COG0857	belongs to the CobB CobQ family
UM146_RS05505	COG0280	phosphate acetyltransferase
UM146_RS05510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UM146_RS05530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UM146_RS05535	COG0490	domain, Protein
UM146_RS05535	COG0471	metal ion transport
UM146_RS05545	COG0436	Aminotransferase
UM146_RS05550	COG0583	DNA-binding transcription factor activity
UM146_RS05570	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
UM146_RS05575	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
UM146_RS05580	COG1034	ATP synthesis coupled electron transport
UM146_RS05595	COG0839	Belongs to the complex I subunit 6 family
UM146_RS05605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UM146_RS05610	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UM146_RS05625	COG2234	aminopeptidase activity
UM146_RS05630	COG2304	oxidoreductase activity
UM146_RS05640	COG2153	protein acetylation
UM146_RS05645	COG4575	ribosome binding
UM146_RS05650	COG1169	isochorismate synthase
UM146_RS05665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
UM146_RS05675	COG0318	PFAM AMP-dependent synthetase and ligase
UM146_RS05740	COG1414	Transcriptional regulator
UM146_RS05750	COG2271	Major facilitator Superfamily
UM146_RS05765	COG5464	transposase or invertase
UM146_RS05770	COG0247	lactate metabolic process
UM146_RS05780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UM146_RS05785	COG2271	Major facilitator Superfamily
UM146_RS05790	COG0584	glycerophosphoryl diester phosphodiesterase
UM146_RS05795	COG3642	lipopolysaccharide core region biosynthetic process
UM146_RS05800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UM146_RS05805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UM146_RS05810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UM146_RS05820	COG3468	outer membrane autotransporter barrel domain protein
UM146_RS05830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UM146_RS05835	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
UM146_RS05840	COG3234	Protein of unknown function (DUF1175)
UM146_RS05845	COG2373	Large extracellular alpha-helical protein
UM146_RS05850	COG5445	Predicted secreted protein (DUF2300)
UM146_RS05855	COG4676	Protein conserved in bacteria
UM146_RS05860	COG0183	Belongs to the thiolase family
UM146_RS05865	COG2031	fatty acid transporter
UM146_RS05870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UM146_RS05875	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UM146_RS05880	COG2204	response regulator
UM146_RS05885	COG3852	Histidine kinase
UM146_RS05890	COG2205	protein histidine kinase activity
UM146_RS05890	COG0784	Response regulator, receiver
UM146_RS05895	COG2197	response regulator
UM146_RS05900	COG2198	Histidine kinase
UM146_RS05900	COG0642	Histidine kinase
UM146_RS05905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UM146_RS05910	COG1477	protein flavinylation
UM146_RS05915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UM146_RS05915	COG2169	Transcriptional regulator
UM146_RS05920	COG3145	DNA-N1-methyladenine dioxygenase activity
UM146_RS05925	COG4615	Cyclic peptide transporter
UM146_RS05945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS05945	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS05950	COG3062	negative regulation of establishment of protein localization
UM146_RS05960	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS05965	COG0348	domain, Protein
UM146_RS05970	COG3043	anaerobic respiration
UM146_RS05975	COG3005	denitrification pathway
UM146_RS05985	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UM146_RS05990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UM146_RS05995	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UM146_RS06005	COG1138	Cytochrome C-type biogenesis protein
UM146_RS06010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UM146_RS06015	COG3088	subunit of a heme lyase
UM146_RS06015	COG4235	cytochrome complex assembly
UM146_RS06020	COG2197	response regulator
UM146_RS06030	COG3468	outer membrane autotransporter barrel domain protein
UM146_RS06035	COG3468	outer membrane autotransporter barrel domain protein
UM146_RS06045	COG3083	sulfuric ester hydrolase activity
UM146_RS06065	COG1061	Type III restriction enzyme res subunit
UM146_RS06070	COG1187	pseudouridine synthase activity
UM146_RS06075	COG2814	Major facilitator Superfamily
UM146_RS06085	COG4172	Belongs to the ABC transporter superfamily
UM146_RS06090	COG4239	(ABC) transporter, permease
UM146_RS06095	COG4174	ABC transporter (Permease)
UM146_RS06100	COG4166	transmembrane transport
UM146_RS06105	COG2200	EAL domain
UM146_RS06110	COG0791	NLP P60 protein
UM146_RS06115	COG0671	phosphoesterase, PA-phosphatase related
UM146_RS06120	COG0523	cobalamin synthesis protein
UM146_RS06125	COG0246	Mannitol dehydrogenase
UM146_RS06140	COG2814	Major facilitator Superfamily
UM146_RS06145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS06145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS06150	COG1105	Belongs to the carbohydrate kinase PfkB family
UM146_RS06155	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
UM146_RS06155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS06155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS06160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS06165	COG2313	pseudouridylate synthase activity
UM146_RS06170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
UM146_RS06175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UM146_RS06185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS06185	COG1522	sequence-specific DNA binding
UM146_RS06195	COG2855	membrane
UM146_RS06200	COG0583	DNA-binding transcription factor activity
UM146_RS06205	COG0833	amino acid
UM146_RS06215	COG4771	TonB-dependent receptor
UM146_RS06235	COG2311	Membrane
UM146_RS06245	COG1609	Transcriptional regulator
UM146_RS06250	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS06260	COG4211	Belongs to the binding-protein-dependent transport system permease family
UM146_RS06265	COG0167	dihydroorotate dehydrogenase activity
UM146_RS06265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
UM146_RS06270	COG0493	'glutamate synthase
UM146_RS06280	COG2949	membrane
UM146_RS06290	COG1346	cytolysis
UM146_RS06300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UM146_RS06310	COG1538	Outer membrane efflux protein
UM146_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS06320	COG0586	Pfam SNARE associated Golgi protein
UM146_RS06330	COG1686	Belongs to the peptidase S11 family
UM146_RS06335	COG0277	FAD linked oxidase domain protein
UM146_RS06340	COG1472	Belongs to the glycosyl hydrolase 3 family
UM146_RS06345	COG1732	Glycine betaine
UM146_RS06350	COG1174	glycine betaine transport
UM146_RS06355	COG1125	glycine betaine transport
UM146_RS06360	COG1174	glycine betaine transport
UM146_RS06370	COG0789	Transcriptional regulator
UM146_RS06375	COG3275	phosphorelay sensor kinase activity
UM146_RS06380	COG3279	Response regulator of the LytR AlgR family
UM146_RS06385	COG4807	Protein conserved in bacteria
UM146_RS06390	COG4808	Protein conserved in bacteria
UM146_RS06400	COG3552	Protein containing von Willebrand factor type A (VWA) domain
UM146_RS06405	COG2425	protein containing a von Willebrand factor type A (vWA) domain
UM146_RS06410	COG0714	Associated with various cellular activities
UM146_RS06430	COG3831	ATPase activity
UM146_RS06440	COG0489	protein tyrosine kinase activity
UM146_RS06455	COG3539	Fimbrial protein
UM146_RS06460	COG3121	Chaperone
UM146_RS06465	COG3188	usher protein
UM146_RS06470	COG3539	Fimbrial protein
UM146_RS06475	COG5455	response to cobalt ion
UM146_RS06495	COG0351	phosphomethylpyrimidine kinase
UM146_RS06500	COG3757	hydrolase, family 25
UM146_RS06505	COG2188	Transcriptional regulator
UM146_RS06510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS06515	COG1397	ADP-ribosylglycohydrolase
UM146_RS06520	COG2211	Major facilitator Superfamily
UM146_RS06525	COG1830	Aldolase
UM146_RS06540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS06545	COG3414	Phosphotransferase system galactitol-specific IIB component
UM146_RS06550	COG3775	system Galactitol-specific IIC component
UM146_RS06555	COG1063	alcohol dehydrogenase
UM146_RS06580	COG0826	peptidase U32
UM146_RS06605	COG3422	double-strand break repair
UM146_RS06610	COG0745	RESPONSE REGULATOR receiver
UM146_RS06615	COG2205	protein histidine kinase activity
UM146_RS06640	COG4245	von Willebrand factor, type A
UM146_RS06645	COG0631	protein serine/threonine phosphatase activity
UM146_RS06650	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
UM146_RS06655	COG0443	Heat shock 70 kDa protein
UM146_RS06660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UM146_RS06665	COG3447	MASE1 domain protein
UM146_RS06665	COG5001	Diguanylate cyclase
UM146_RS06665	COG5002	protein histidine kinase activity
UM146_RS06670	COG0572	uridine kinase
UM146_RS06680	COG2982	Protein involved in outer membrane biogenesis
UM146_RS06695	COG1253	flavin adenine dinucleotide binding
UM146_RS06700	COG1596	polysaccharide export
UM146_RS06705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UM146_RS06710	COG3206	protein involved in exopolysaccharide biosynthesis
UM146_RS06710	COG0489	protein tyrosine kinase activity
UM146_RS06715	COG0463	Glycosyl transferase, family 2
UM146_RS06720	COG1045	serine acetyltransferase
UM146_RS06725	COG0438	transferase activity, transferring glycosyl groups
UM146_RS06735	COG1216	Glycosyl transferase, family 2
UM146_RS06740	COG0110	maltose O-acetyltransferase activity
UM146_RS06745	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
UM146_RS06750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UM146_RS06755	COG1051	belongs to the nudix hydrolase family
UM146_RS06765	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
UM146_RS06765	COG0662	Cupin 2, conserved barrel domain protein
UM146_RS06770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UM146_RS06775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UM146_RS06780	COG2244	polysaccharide biosynthetic process
UM146_RS06785	COG2327	Polysaccharide pyruvyl transferase
UM146_RS06790	COG0438	transferase activity, transferring glycosyl groups
UM146_RS06800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UM146_RS06805	COG1088	dTDP-glucose 4,6-dehydratase activity
UM146_RS06810	COG1091	dTDP-4-dehydrorhamnose reductase activity
UM146_RS06815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
UM146_RS06845	COG0438	transferase activity, transferring glycosyl groups
UM146_RS06850	COG0438	transferase activity, transferring glycosyl groups
UM146_RS06855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UM146_RS06860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UM146_RS06865	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
UM146_RS06870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UM146_RS06870	COG0140	phosphoribosyl-ATP diphosphatase activity
UM146_RS06885	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UM146_RS06890	COG0131	Imidazoleglycerol-phosphate dehydratase
UM146_RS06890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UM146_RS06900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UM146_RS06910	COG2161	toxin-antitoxin pair type II binding
UM146_RS06915	COG4115	mRNA cleavage
UM146_RS06920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UM146_RS06925	COG0583	DNA-binding transcription factor activity
UM146_RS06930	COG0531	amino acid
UM146_RS06935	COG2925	Exonuclease
UM146_RS06950	COG1289	transmembrane transporter activity
UM146_RS06990	COG2003	Belongs to the UPF0758 family
UM146_RS07045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM146_RS07050	COG1120	ATPase activity
UM146_RS07095	COG3547	Transposase (IS116 IS110 IS902 family)
UM146_RS07145	COG0405	Gamma-glutamyltransferase
UM146_RS07150	COG1735	metal-dependent hydrolase with the TIM-barrel fold
UM146_RS07175	COG3547	Transposase (IS116 IS110 IS902 family)
UM146_RS07195	COG1215	transferase activity, transferring glycosyl groups
UM146_RS07200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UM146_RS07205	COG3969	phosphoadenosine phosphosulfate
UM146_RS07210	COG1475	DNA binding
UM146_RS07215	COG4771	TonB-dependent receptor
UM146_RS07230	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
UM146_RS07245	COG1376	ErfK ybiS ycfS ynhG family protein
UM146_RS07255	COG2801	Transposase and inactivated derivatives
UM146_RS07270	COG2197	response regulator
UM146_RS07290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UM146_RS07295	COG1960	acyl-CoA dehydrogenase activity
UM146_RS07325	COG0154	amidase activity
UM146_RS07365	COG0582	viral genome integration into host DNA
UM146_RS07375	COG0534	Mate efflux family protein
UM146_RS07390	COG0583	DNA-binding transcription factor activity
UM146_RS07395	COG0583	DNA-binding transcription factor activity
UM146_RS07405	COG0534	Mate efflux family protein
UM146_RS07415	COG0217	transcriptional regulatory protein
UM146_RS07420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UM146_RS07425	COG0477	Major facilitator Superfamily
UM146_RS07435	COG1388	LysM domain
UM146_RS07435	COG1470	cell adhesion involved in biofilm formation
UM146_RS07440	COG1388	LysM domain
UM146_RS07440	COG1470	cell adhesion involved in biofilm formation
UM146_RS07445	COG1388	LysM domain
UM146_RS07445	COG1470	cell adhesion involved in biofilm formation
UM146_RS07450	COG4932	domain protein
UM146_RS07450	COG2373	Large extracellular alpha-helical protein
UM146_RS07450	COG1388	LysM domain
UM146_RS07455	COG4771	TonB-dependent receptor
UM146_RS07460	COG1021	2,3-dihydroxybenzoate-AMP ligase
UM146_RS07480	COG3433	isochorismatase activity
UM146_RS07480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UM146_RS07480	COG2226	methyltransferase
UM146_RS07485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UM146_RS07485	COG2226	methyltransferase
UM146_RS07485	COG3433	isochorismatase activity
UM146_RS07500	COG1132	(ABC) transporter
UM146_RS07505	COG2814	Major facilitator Superfamily
UM146_RS07510	COG1169	isochorismate synthase
UM146_RS07540	COG3443	Belongs to the bacterial solute-binding protein 9 family
UM146_RS07555	COG2351	hydroxyisourate hydrolase activity
UM146_RS07560	COG0745	RESPONSE REGULATOR receiver
UM146_RS07565	COG2205	protein histidine kinase activity
UM146_RS07580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UM146_RS07595	COG1418	mRNA catabolic process
UM146_RS07600	COG0270	DNA (cytosine-5-)-methyltransferase activity
UM146_RS07605	COG3727	T/G mismatch-specific endonuclease activity
UM146_RS07610	COG0697	spore germination
UM146_RS07615	COG2354	Protein conserved in bacteria
UM146_RS07640	COG2197	response regulator
UM146_RS07645	COG1684	flagellar biosynthetic protein fliR
UM146_RS07650	COG1987	bacterial-type flagellum assembly
UM146_RS07655	COG1338	Plays a role in the flagellum-specific transport system
UM146_RS07660	COG3190	flagellar
UM146_RS07665	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UM146_RS07670	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UM146_RS07675	COG1580	Controls the rotational direction of flagella during chemotaxis
UM146_RS07680	COG3144	bacterial-type flagellum assembly
UM146_RS07685	COG2882	bacterial-type flagellum organization
UM146_RS07690	COG1157	protein secretion by the type III secretion system
UM146_RS07695	COG1317	bacterial-type flagellum organization
UM146_RS07700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UM146_RS07705	COG1766	The M ring may be actively involved in energy transduction
UM146_RS07725	COG2076	Multidrug Resistance protein
UM146_RS07730	COG1881	PFAM PEBP family protein
UM146_RS07735	COG2207	Transcriptional regulator
UM146_RS07745	COG2135	peptidase activity
UM146_RS07750	COG0425	Belongs to the sulfur carrier protein TusA family
UM146_RS07755	COG2391	methyltransferase activity
UM146_RS07765	COG0366	Alpha amylase catalytic
UM146_RS07775	COG1516	flagellar protein fliS
UM146_RS07780	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UM146_RS07790	COG1191	sigma factor activity
UM146_RS07800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS07810	COG0765	amino acid transport
UM146_RS07815	COG1126	abc transporter atp-binding protein
UM146_RS07820	COG2197	response regulator
UM146_RS07835	COG2197	response regulator
UM146_RS07865	COG3012	SEC-C Motif Domain Protein
UM146_RS07865	COG3318	Belongs to the UPF0149 family
UM146_RS07880	COG1528	Iron-storage protein
UM146_RS07900	COG1528	Iron-storage protein
UM146_RS07905	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS07915	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS07920	COG1877	trehalose-phosphatase activity
UM146_RS07930	COG0589	response to stress
UM146_RS07945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UM146_RS07950	COG1360	Flagellar Motor Protein
UM146_RS07955	COG2198	Histidine kinase
UM146_RS07955	COG0643	Histidine kinase
UM146_RS07960	COG0835	chemotaxis
UM146_RS07965	COG0840	transmembrane signaling receptor activity
UM146_RS07975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UM146_RS07985	COG0745	RESPONSE REGULATOR receiver
UM146_RS07990	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
UM146_RS07995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UM146_RS08000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UM146_RS08015	COG3102	Protein conserved in bacteria
UM146_RS08025	COG3005	denitrification pathway
UM146_RS08030	COG0243	molybdopterin cofactor binding
UM146_RS08045	COG3788	relative of glutathione S-transferase, MAPEG superfamily
UM146_RS08050	COG1801	Protein of unknown function DUF72
UM146_RS08055	COG1335	isochorismatase
UM146_RS08065	COG0494	nUDIX hydrolase
UM146_RS08070	COG0217	transcriptional regulatory protein
UM146_RS08095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UM146_RS08105	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
UM146_RS08110	COG0739	heme binding
UM146_RS08115	COG1560	Kdo2-lipid A biosynthetic process
UM146_RS08120	COG0469	pyruvate kinase activity
UM146_RS08125	COG1737	Transcriptional regulator
UM146_RS08135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UM146_RS08140	COG0129	dihydroxy-acid dehydratase activity
UM146_RS08145	COG0800	Aldolase
UM146_RS08155	COG3141	response to X-ray
UM146_RS08170	COG2979	Protein of unknown function (DUF533)
UM146_RS08175	COG1770	oligopeptidase
UM146_RS08180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UM146_RS08185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UM146_RS08195	COG2372	response to copper ion
UM146_RS08200	COG1276	copper resistance
UM146_RS08215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UM146_RS08235	COG3008	intermembrane lipid transfer
UM146_RS08240	COG2995	paraquat-inducible protein a
UM146_RS08245	COG1956	GAF domain-containing protein
UM146_RS08255	COG0793	Belongs to the peptidase S41A family
UM146_RS08265	COG2814	Major facilitator Superfamily
UM146_RS08270	COG1414	Transcriptional regulator
UM146_RS08305	COG2226	methyltransferase
UM146_RS08325	COG3716	PTS system mannose fructose sorbose family IID component
UM146_RS08330	COG3715	PTS system
UM146_RS08335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS08335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS08345	COG1253	flavin adenine dinucleotide binding
UM146_RS08350	COG2200	EAL domain
UM146_RS08355	COG1760	l-serine dehydratase
UM146_RS08365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UM146_RS08385	COG0251	oxidation-reduction process
UM146_RS08390	COG1199	ATP-dependent helicase activity
UM146_RS08395	COG1214	PFAM Peptidase M22, glycoprotease
UM146_RS08400	COG3065	identical protein binding
UM146_RS08405	COG0318	PFAM AMP-dependent synthetase and ligase
UM146_RS08410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
UM146_RS08415	COG0473	3-isopropylmalate dehydrogenase activity
UM146_RS08420	COG0583	DNA-binding transcription factor activity
UM146_RS08430	COG3615	Tellurite resistance protein tehB
UM146_RS08440	COG2261	transglycosylase associated protein
UM146_RS08450	COG2203	Gaf domain
UM146_RS08450	COG2199	diguanylate cyclase activity
UM146_RS08455	COG3042	response to heat
UM146_RS08460	COG3189	MarR family transcriptional regulator
UM146_RS08465	COG2807	transmembrane transport
UM146_RS08470	COG2207	Transcriptional regulator
UM146_RS08485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UM146_RS08490	COG2199	diguanylate cyclase activity
UM146_RS08495	COG2199	diguanylate cyclase activity
UM146_RS08505	COG2766	serine protein kinase
UM146_RS08510	COG3713	MltA-interacting MipA family protein
UM146_RS08515	COG0656	L-ascorbic acid biosynthetic process
UM146_RS08520	COG0676	glucose-6-phosphate 1-epimerase activity
UM146_RS08525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UM146_RS08535	COG3139	Protein of unknown function (DUF1315)
UM146_RS08540	COG1063	alcohol dehydrogenase
UM146_RS08545	COG2271	Major facilitator Superfamily
UM146_RS08550	COG1063	alcohol dehydrogenase
UM146_RS08555	COG0191	fructose-bisphosphate aldolase activity
UM146_RS08560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS08565	COG0667	Aldo Keto reductase
UM146_RS08570	COG1349	DNA-binding transcription factor activity
UM146_RS08575	COG2814	Major facilitator Superfamily
UM146_RS08580	COG1335	isochorismatase
UM146_RS08585	COG0252	asparaginase activity
UM146_RS08590	COG0616	signal peptide processing
UM146_RS08600	COG0778	Nitroreductase
UM146_RS08615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UM146_RS08620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UM146_RS08630	COG0494	nUDIX hydrolase
UM146_RS08635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UM146_RS08640	COG2897	thiosulfate sulfurtransferase activity
UM146_RS08645	COG4136	ATPase activity
UM146_RS08650	COG4135	transport system, permease component
UM146_RS08660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UM146_RS08665	COG0398	Pfam SNARE associated Golgi protein
UM146_RS08675	COG0398	Pfam SNARE associated Golgi protein
UM146_RS08680	COG0708	Exodeoxyribonuclease III
UM146_RS08710	COG3678	ATP-independent chaperone mediated protein folding
UM146_RS08720	COG0322	excinuclease ABC activity
UM146_RS08735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UM146_RS08740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UM146_RS08745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UM146_RS08750	COG1447	Phosphotransferase system cellobiose-specific component IIA
UM146_RS08755	COG2169	Transcriptional regulator
UM146_RS08755	COG1917	Cupin 2, conserved barrel domain protein
UM146_RS08760	COG1486	melibiose metabolic process
UM146_RS08770	COG0753	catalase activity
UM146_RS08780	COG1823	symporter activity
UM146_RS08785	COG1988	membrane-bound metal-dependent
UM146_RS08790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UM146_RS08800	COG3001	Fructosamine kinase
UM146_RS08810	COG1105	Belongs to the carbohydrate kinase PfkB family
UM146_RS08815	COG3137	Salt-induced outer membrane protein
UM146_RS08875	COG0386	Belongs to the glutathione peroxidase family
UM146_RS08885	COG0791	NLP P60 protein
UM146_RS08890	COG2200	EAL domain
UM146_RS08900	COG4256	Hemin uptake protein
UM146_RS08905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UM146_RS08920	COG0574	Belongs to the PEP-utilizing enzyme family
UM146_RS08920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UM146_RS08925	COG0318	PFAM AMP-dependent synthetase and ligase
UM146_RS08930	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
UM146_RS08935	COG0644	oxidoreductase
UM146_RS08940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UM146_RS08945	COG2086	electron transfer activity
UM146_RS08955	COG2207	Transcriptional regulator
UM146_RS08955	COG1917	Cupin 2, conserved barrel domain protein
UM146_RS08960	COG1960	acyl-CoA dehydrogenase activity
UM146_RS08965	COG4670	ketone body catabolic process
UM146_RS08980	COG2271	Major facilitator Superfamily
UM146_RS08985	COG0738	Major facilitator superfamily
UM146_RS09000	COG0277	FAD linked oxidase domain protein
UM146_RS09000	COG0247	lactate metabolic process
UM146_RS09005	COG2050	protein possibly involved in aromatic compounds catabolism
UM146_RS09015	COG0316	Belongs to the HesB IscA family
UM146_RS09020	COG0719	Fe-S assembly protein
UM146_RS09025	COG0396	ATPase activity
UM146_RS09030	COG0719	Fe-S assembly protein
UM146_RS09045	COG1376	ErfK ybiS ycfS ynhG family protein
UM146_RS09050	COG4238	major outer membrane lipoprotein
UM146_RS09055	COG0469	pyruvate kinase activity
UM146_RS09065	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS09070	COG2414	aldehyde ferredoxin oxidoreductase
UM146_RS09080	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS09085	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
UM146_RS09095	COG4529	Protein conserved in bacteria
UM146_RS09115	COG3468	outer membrane autotransporter barrel domain protein
UM146_RS09125	COG0307	riboflavin synthase, alpha
UM146_RS09130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UM146_RS09135	COG2814	Major facilitator Superfamily
UM146_RS09140	COG0583	DNA-binding transcription factor activity
UM146_RS09155	COG2814	Major facilitator Superfamily
UM146_RS09160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UM146_RS09165	COG0791	NLP P60 protein
UM146_RS09170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
UM146_RS09175	COG1201	RNA secondary structure unwinding
UM146_RS09185	COG0346	lactoylglutathione lyase activity
UM146_RS09190	COG1902	pentaerythritol trinitrate reductase activity
UM146_RS09195	COG1309	transcriptional regulator
UM146_RS09200	COG3313	Fe-S protein
UM146_RS09205	COG4989	oxidoreductase activity
UM146_RS09210	COG2032	superoxide dismutase activity
UM146_RS09215	COG1289	transmembrane transporter activity
UM146_RS09220	COG1566	PFAM secretion protein HlyD family protein
UM146_RS09235	COG3133	Outer membrane lipoprotein
UM146_RS09245	COG3895	Periplasmic Protein
UM146_RS09265	COG0625	glutathione transferase activity
UM146_RS09270	COG3104	oligopeptide transport
UM146_RS09280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UM146_RS09290	COG4659	FMN binding
UM146_RS09330	COG0673	inositol 2-dehydrogenase activity
UM146_RS09340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UM146_RS09345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS09345	COG1263	PTS System
UM146_RS09350	COG1609	Transcriptional regulator
UM146_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS09360	COG1309	transcriptional regulator
UM146_RS09365	COG3250	beta-galactosidase activity
UM146_RS09380	COG5339	Protein conserved in bacteria
UM146_RS09385	COG1482	cell wall glycoprotein biosynthetic process
UM146_RS09390	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
UM146_RS09390	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
UM146_RS09395	COG0114	fumarate hydratase activity
UM146_RS09410	COG0745	RESPONSE REGULATOR receiver
UM146_RS09415	COG3136	membrane protein required for alginate biosynthesis
UM146_RS09425	COG0531	amino acid
UM146_RS09435	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
UM146_RS09440	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
UM146_RS09445	COG0628	permease
UM146_RS09460	COG3591	Belongs to the peptidase S1B family
UM146_RS09475	COG2814	Major facilitator Superfamily
UM146_RS09480	COG0583	DNA-binding transcription factor activity
UM146_RS09485	COG1940	carbohydrate kinase activity
UM146_RS09490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UM146_RS09500	COG3381	protein complex oligomerization
UM146_RS09505	COG3302	dmso reductase anchor subunit
UM146_RS09510	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS09515	COG0243	molybdopterin cofactor binding
UM146_RS09535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM146_RS09550	COG4948	Mandelate Racemase Muconate Lactonizing
UM146_RS09555	COG1063	alcohol dehydrogenase
UM146_RS09560	COG0477	Major facilitator Superfamily
UM146_RS09565	COG0246	Mannitol dehydrogenase
UM146_RS09575	COG1802	Transcriptional regulator
UM146_RS09580	COG4221	oxidoreductase activity
UM146_RS09585	COG0339	signal peptide processing
UM146_RS09590	COG3111	PFAM Bacterial OB fold (BOF) protein
UM146_RS09595	COG3706	GGDEF domain
UM146_RS09605	COG2814	Major facilitator Superfamily
UM146_RS09610	COG0697	spore germination
UM146_RS09615	COG2188	Transcriptional regulator
UM146_RS09625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UM146_RS09630	COG1447	Phosphotransferase system cellobiose-specific component IIA
UM146_RS09640	COG2723	6-phospho-beta-galactosidase activity
UM146_RS09650	COG4977	sequence-specific DNA binding
UM146_RS09655	COG1846	Transcriptional regulator
UM146_RS09670	COG0583	DNA-binding transcription factor activity
UM146_RS09675	COG1012	belongs to the aldehyde dehydrogenase family
UM146_RS09680	COG2066	Belongs to the glutaminase family
UM146_RS09690	COG2199	diguanylate cyclase activity
UM146_RS09705	COG3781	membrane
UM146_RS09715	COG1396	sequence-specific DNA binding
UM146_RS09720	COG3550	peptidyl-serine autophosphorylation
UM146_RS09800	COG0702	epimerase
UM146_RS09810	COG3539	Fimbrial protein
UM146_RS09820	COG3188	usher protein
UM146_RS09825	COG3539	Fimbrial protein
UM146_RS09830	COG3539	Fimbrial protein
UM146_RS09835	COG3539	Fimbrial protein
UM146_RS09840	COG0243	molybdopterin cofactor binding
UM146_RS09850	COG2207	Transcriptional regulator
UM146_RS09855	COG3119	arylsulfatase activity
UM146_RS09860	COG0641	radical SAM
UM146_RS09865	COG4178	(ABC) transporter
UM146_RS09870	COG4771	TonB-dependent receptor
UM146_RS09875	COG0612	Peptidase, M16
UM146_RS09885	COG0076	glutamate decarboxylase activity
UM146_RS09890	COG0531	amino acid
UM146_RS09895	COG1649	PFAM Uncharacterised BCR, COG1649
UM146_RS09900	COG3706	GGDEF domain
UM146_RS09900	COG3706	GGDEF domain
UM146_RS09905	COG2199	diguanylate cyclase activity
UM146_RS09905	COG2200	EAL domain
UM146_RS09905	COG2202	Pas domain
UM146_RS09910	COG1764	response to oxidative stress
UM146_RS09930	COG1064	alcohol dehydrogenase
UM146_RS09940	COG3093	addiction module antidote protein HigA
UM146_RS09945	COG2864	formate dehydrogenase
UM146_RS09950	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS09955	COG0243	molybdopterin cofactor binding
UM146_RS09955	COG3383	formate dehydrogenase (NAD+) activity
UM146_RS09960	COG3383	formate dehydrogenase (NAD+) activity
UM146_RS09960	COG0243	molybdopterin cofactor binding
UM146_RS09965	COG0697	spore germination
UM146_RS09970	COG2223	nitrite transmembrane transporter activity
UM146_RS09975	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
UM146_RS09980	COG1140	nitrate reductase beta subunit
UM146_RS09985	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
UM146_RS09990	COG2181	nitrate reductase activity
UM146_RS09995	COG0384	phenazine biosynthesis protein PhzF
UM146_RS10000	COG2162	N-hydroxyarylamine O-acetyltransferase activity
UM146_RS10005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UM146_RS10020	COG5433	transposase activity
UM146_RS10035	COG3501	Rhs element vgr protein
UM146_RS10045	COG0625	glutathione transferase activity
UM146_RS10050	COG0625	glutathione transferase activity
UM146_RS10055	COG1113	amino acid transport
UM146_RS10065	COG4772	TonB-dependent receptor
UM146_RS10070	COG1802	Transcriptional regulator
UM146_RS10075	COG1247	-acetyltransferase
UM146_RS10080	COG3238	Protein conserved in bacteria
UM146_RS10105	COG1177	transmembrane transport
UM146_RS10110	COG1176	ABC-type spermidine putrescine transport system, permease component I
UM146_RS10115	COG3842	ATPase activity
UM146_RS10120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
UM146_RS10125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UM146_RS10140	COG0826	peptidase U32
UM146_RS10145	COG1396	sequence-specific DNA binding
UM146_RS10160	COG0500	methyltransferase
UM146_RS10165	COG1275	C4-dicarboxylate transporter malic acid transport protein
UM146_RS10170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UM146_RS10175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM146_RS10180	COG2841	Protein conserved in bacteria
UM146_RS10195	COG5383	Protein conserved in bacteria
UM146_RS10200	COG0583	DNA-binding transcription factor activity
UM146_RS10220	COG3038	cytochrome b561
UM146_RS10225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UM146_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
UM146_RS10235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
UM146_RS10240	COG1643	Atp-dependent helicase
UM146_RS10250	COG0671	phosphoesterase, PA-phosphatase related
UM146_RS10250	COG2453	phosphatase
UM146_RS10255	COG2267	carboxylic ester hydrolase activity
UM146_RS10260	COG4589	Belongs to the CDS family
UM146_RS10265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UM146_RS10270	COG0667	Aldo Keto reductase
UM146_RS10300	COG3784	Protein of unknown function (DUF1318)
UM146_RS10310	COG2911	Protein conserved in bacteria
UM146_RS10315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UM146_RS10320	COG3187	Heat shock protein
UM146_RS10325	COG3042	response to heat
UM146_RS10330	COG0674	pyruvate-flavodoxin oxidoreductase activity
UM146_RS10330	COG1013	pyruvate-flavodoxin oxidoreductase activity
UM146_RS10330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UM146_RS10330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UM146_RS10335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UM146_RS10340	COG0589	response to stress
UM146_RS10350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UM146_RS10360	COG0582	viral genome integration into host DNA
UM146_RS10370	COG0513	Belongs to the DEAD box helicase family
UM146_RS10385	COG3706	GGDEF domain
UM146_RS10390	COG2840	Smr protein MutS2
UM146_RS10405	COG2207	Transcriptional regulator
UM146_RS10415	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
UM146_RS10420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UM146_RS10425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UM146_RS10430	COG0589	response to stress
UM146_RS10435	COG3182	Iron-regulated membrane protein
UM146_RS10440	COG0668	transmembrane transport
UM146_RS10445	COG4166	transmembrane transport
UM146_RS10455	COG0583	DNA-binding transcription factor activity
UM146_RS10460	COG1073	alpha beta
UM146_RS10465	COG0702	epimerase
UM146_RS10470	COG2866	Carboxypeptidase
UM146_RS10475	COG4948	Mandelate Racemase Muconate Lactonizing
UM146_RS10480	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UM146_RS10485	COG3283	Transcriptional regulator of aromatic amino acids metabolism
UM146_RS10495	COG3106	COG3106 Predicted ATPase
UM146_RS10500	COG1609	Transcriptional regulator
UM146_RS10515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UM146_RS10520	COG1554	hydrolase, family 65, central catalytic
UM146_RS10525	COG0673	inositol 2-dehydrogenase activity
UM146_RS10530	COG1082	Xylose isomerase domain protein TIM barrel
UM146_RS10535	COG1063	alcohol dehydrogenase
UM146_RS10540	COG0395	ABC-type sugar transport system, permease component
UM146_RS10545	COG1175	transmembrane transport
UM146_RS10550	COG1653	transport
UM146_RS10555	COG0366	Alpha amylase catalytic
UM146_RS10560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UM146_RS10570	COG1983	PspC domain protein
UM146_RS10580	COG1842	Phage shock protein A
UM146_RS10585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
UM146_RS10605	COG4166	transmembrane transport
UM146_RS10610	COG4168	peptide transport system, permease
UM146_RS10615	COG4171	peptide transport system, permease
UM146_RS10620	COG4172	Belongs to the ABC transporter superfamily
UM146_RS10625	COG4172	Belongs to the ABC transporter superfamily
UM146_RS10630	COG2814	Major facilitator Superfamily
UM146_RS10645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UM146_RS10655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UM146_RS10660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UM146_RS10660	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UM146_RS10675	COG5001	Diguanylate cyclase
UM146_RS10695	COG0023	Translation Initiation Factor
UM146_RS10705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
UM146_RS10710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
UM146_RS10715	COG0671	phosphoesterase, PA-phosphatase related
UM146_RS10725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UM146_RS10750	COG0583	DNA-binding transcription factor activity
UM146_RS10755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UM146_RS10770	COG0616	signal peptide processing
UM146_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS10785	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
UM146_RS10790	COG1187	pseudouridine synthase activity
UM146_RS10795	COG4907	membrane protein (DUF2207)
UM146_RS10800	COG0009	L-threonylcarbamoyladenylate synthase
UM146_RS10805	COG0613	PHP domain protein
UM146_RS10810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UM146_RS10815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UM146_RS10815	COG0512	Glutamine amidotransferase of anthranilate synthase
UM146_RS10820	COG0135	phosphoribosylanthranilate isomerase activity
UM146_RS10820	COG0134	indole-3-glycerol-phosphate synthase activity
UM146_RS10835	COG3729	General stress protein
UM146_RS10840	COG3685	Protein conserved in bacteria
UM146_RS10845	COG3685	Protein conserved in bacteria
UM146_RS10860	COG0500	methyltransferase
UM146_RS10865	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
UM146_RS10870	COG5301	cellulose 1,4-beta-cellobiosidase activity
UM146_RS10985	COG4220	transposase activity
UM146_RS11000	COG5562	phage envelope protein
UM146_RS11010	COG3772	lysozyme
UM146_RS11070	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
UM146_RS11075	COG1403	HNH endonuclease
UM146_RS11155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UM146_RS11170	COG3047	cAMP biosynthetic process
UM146_RS11185	COG1607	acyl-coa hydrolase
UM146_RS11195	COG2350	Protein conserved in bacteria
UM146_RS11200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UM146_RS11220	COG4608	Belongs to the ABC transporter superfamily
UM146_RS11225	COG0444	Belongs to the ABC transporter superfamily
UM146_RS11230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UM146_RS11235	COG0601	transmembrane transport
UM146_RS11240	COG4166	transmembrane transport
UM146_RS11245	COG2095	MarC family integral membrane protein
UM146_RS11250	COG1454	alcohol dehydrogenase
UM146_RS11250	COG1012	belongs to the aldehyde dehydrogenase family
UM146_RS11255	COG3385	transposase activity
UM146_RS11260	COG1435	thymidine kinase activity
UM146_RS11270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UM146_RS11275	COG0745	RESPONSE REGULATOR receiver
UM146_RS11280	COG1752	Esterase of the alpha-beta hydrolase superfamily
UM146_RS11290	COG0788	formyltetrahydrofolate deformylase activity
UM146_RS11310	COG2181	nitrate reductase activity
UM146_RS11315	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
UM146_RS11320	COG1140	nitrate reductase beta subunit
UM146_RS11325	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
UM146_RS11330	COG2223	nitrite transmembrane transporter activity
UM146_RS11340	COG3850	Histidine kinase
UM146_RS11345	COG2197	response regulator
UM146_RS11350	COG4932	domain protein
UM146_RS11355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
UM146_RS11360	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
UM146_RS11365	COG4572	Cation transport regulator
UM146_RS11370	COG0387	Pfam Sodium calcium exchanger
UM146_RS11385	COG2912	Transglutaminase-like superfamily
UM146_RS11390	COG3094	Invasion gene expression up-regulator, SirB
UM146_RS11395	COG2890	protein-(glutamine-N5) methyltransferase activity
UM146_RS11420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UM146_RS11425	COG0659	secondary active sulfate transmembrane transporter activity
UM146_RS11440	COG0012	GTP binding
UM146_RS11450	COG3284	Transcriptional regulator
UM146_RS11455	COG2376	Dihydroxyacetone kinase
UM146_RS11460	COG1461	Dihydroxyacetone kinase
UM146_RS11465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UM146_RS11465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS11465	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
UM146_RS11475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UM146_RS11480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM146_RS11485	COG1120	ATPase activity
UM146_RS11490	COG0500	methyltransferase
UM146_RS11495	COG0157	Belongs to the NadC ModD family
UM146_RS11510	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
UM146_RS11520	COG1619	proteins homologs of microcin C7 resistance protein MccF
UM146_RS11530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UM146_RS11540	COG2719	SpoVR family
UM146_RS11560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UM146_RS11565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UM146_RS11580	COG0179	Fumarylacetoacetate (FAA) hydrolase
UM146_RS11605	COG2894	cell division
UM146_RS11675	COG2200	EAL domain
UM146_RS11680	COG0789	Transcriptional regulator
UM146_RS11685	COG5562	phage envelope protein
UM146_RS11715	COG1121	(ABC) transporter
UM146_RS11720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UM146_RS11725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UM146_RS11850	COG4220	transposase activity
UM146_RS11890	COG3772	lysozyme
UM146_RS12080	COG0582	viral genome integration into host DNA
UM146_RS12085	COG0538	isocitrate dehydrogenase activity
UM146_RS12090	COG1187	pseudouridine synthase activity
UM146_RS12110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UM146_RS12120	COG2205	protein histidine kinase activity
UM146_RS12125	COG2850	peptidyl-arginine hydroxylation
UM146_RS12150	COG1177	transmembrane transport
UM146_RS12155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
UM146_RS12165	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UM146_RS12170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
UM146_RS12180	COG4591	ABC-type transport system involved in lipoprotein release permease component
UM146_RS12190	COG4591	ABC-type transport system involved in lipoprotein release permease component
UM146_RS12200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UM146_RS12205	COG1388	LysM domain
UM146_RS12205	COG1376	ErfK ybiS ycfS ynhG family protein
UM146_RS12215	COG1309	transcriptional regulator
UM146_RS12220	COG3134	Outer membrane lipoprotein
UM146_RS12225	COG1252	NADH dehydrogenase
UM146_RS12245	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
UM146_RS12250	COG5633	Lipoprotein
UM146_RS12255	COG0537	adenosine 5'-monophosphoramidase activity
UM146_RS12260	COG4773	Receptor
UM146_RS12265	COG1263	PTS System
UM146_RS12265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS12270	COG0084	hydrolase, TatD family'
UM146_RS12275	COG0470	DNA polymerase III
UM146_RS12285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UM146_RS12290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UM146_RS12295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UM146_RS12305	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS12310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UM146_RS12330	COG1399	metal-binding, possibly nucleic acid-binding protein
UM146_RS12335	COG0424	maF-like protein
UM146_RS12340	COG0564	pseudouridine synthase activity
UM146_RS12350	COG1530	ribonuclease E activity
UM146_RS12355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UM146_RS12360	COG1256	bacterial-type flagellum assembly
UM146_RS12365	COG3951	Flagellar rod assembly protein muramidase FlgJ
UM146_RS12365	COG1705	Flagellar rod assembly protein muramidase FlgJ
UM146_RS12380	COG4786	Flagellar basal body rod
UM146_RS12385	COG4787	bacterial-type flagellum-dependent cell motility
UM146_RS12390	COG1749	Flagellar hook protein flgE
UM146_RS12395	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UM146_RS12400	COG1558	bacterial-type flagellum-dependent cell motility
UM146_RS12405	COG1815	bacterial-type flagellum-dependent cell motility
UM146_RS12410	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
UM146_RS12415	COG2747	anti-sigma28 factor FlgM
UM146_RS12420	COG3418	PFAM FlgN family protein
UM146_RS12425	COG0728	peptidoglycan biosynthetic process
UM146_RS12430	COG0673	inositol 2-dehydrogenase activity
UM146_RS12440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UM146_RS12450	COG2999	glutathione oxidoreductase activity
UM146_RS12485	COG3038	cytochrome b561
UM146_RS12490	COG2353	YceI-like domain
UM146_RS12500	COG1560	Kdo2-lipid A biosynthetic process
UM146_RS12520	COG5645	(Lipo)protein
UM146_RS12525	COG2943	transferase activity, transferring hexosyl groups
UM146_RS12550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UM146_RS12555	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
UM146_RS12585	COG2197	response regulator
UM146_RS12600	COG1462	curli production assembly transport component CsgG
UM146_RS12610	COG3381	protein complex oligomerization
UM146_RS12665	COG2003	Belongs to the UPF0758 family
UM146_RS12685	COG3468	outer membrane autotransporter barrel domain protein
UM146_RS12720	COG4372	Transposase
UM146_RS12725	COG0523	cobalamin synthesis protein
UM146_RS12735	COG4771	TonB-dependent receptor
UM146_RS12760	COG3385	transposase activity
UM146_RS12780	COG2382	esterase
UM146_RS12785	COG2819	hydrolase of the alpha beta superfamily
UM146_RS12830	COG3539	Fimbrial protein
UM146_RS12860	COG2721	sulfolactate sulfo-lyase activity
UM146_RS12865	COG2721	sulfolactate sulfo-lyase activity
UM146_RS12870	COG2721	sulfolactate sulfo-lyase activity
UM146_RS12875	COG1349	DNA-binding transcription factor activity
UM146_RS12880	COG1349	DNA-binding transcription factor activity
UM146_RS12885	COG2222	sugar isomerase
UM146_RS12890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UM146_RS12900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UM146_RS12910	COG4983	Phage plasmid primase, P4 family domain protein
UM146_RS12935	COG0582	viral genome integration into host DNA
UM146_RS12945	COG3706	GGDEF domain
UM146_RS12950	COG0457	Tetratricopeptide repeat
UM146_RS12955	COG0726	polysaccharide deacetylase
UM146_RS12955	COG1649	PFAM Uncharacterised BCR, COG1649
UM146_RS12960	COG1215	transferase activity, transferring glycosyl groups
UM146_RS12965	COG3658	cytochrome
UM146_RS12970	COG1702	phosphate starvation-inducible protein PhoH
UM146_RS12990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UM146_RS13000	COG0506	proline dehydrogenase activity
UM146_RS13000	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
UM146_RS13000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
UM146_RS13005	COG1309	transcriptional regulator
UM146_RS13045	COG3729	General stress protein
UM146_RS13085	COG0243	molybdopterin cofactor binding
UM146_RS13090	COG3005	denitrification pathway
UM146_RS13095	COG0745	RESPONSE REGULATOR receiver
UM146_RS13100	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS13105	COG2205	protein histidine kinase activity
UM146_RS13105	COG2198	Histidine kinase
UM146_RS13105	COG0784	Response regulator, receiver
UM146_RS13110	COG0348	domain, Protein
UM146_RS13125	COG1278	Cold shock
UM146_RS13130	COG1278	Cold shock
UM146_RS13145	COG1294	oxidase, subunit
UM146_RS13150	COG1271	oxidase subunit
UM146_RS13155	COG1773	rubredoxin
UM146_RS13160	COG1999	signal sequence binding
UM146_RS13165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
UM146_RS13170	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
UM146_RS13175	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
UM146_RS13180	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
UM146_RS13190	COG0670	Belongs to the BI1 family
UM146_RS13195	COG2920	part of a sulfur-relay system
UM146_RS13215	COG1832	CoA-binding protein
UM146_RS13235	COG0210	DNA helicase
UM146_RS13240	COG3304	Inner membrane component domain
UM146_RS13245	COG1289	transmembrane transporter activity
UM146_RS13250	COG3070	regulator of competence-specific genes
UM146_RS13265	COG2885	chlorophyll binding
UM146_RS13265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
UM146_RS13275	COG1067	ATP-dependent peptidase activity
UM146_RS13285	COG3130	regulation of translation
UM146_RS13290	COG3009	Protein conserved in bacteria
UM146_RS13295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UM146_RS13295	COG3008	intermembrane lipid transfer
UM146_RS13300	COG2995	paraquat-inducible protein a
UM146_RS13305	COG0488	(ABC) transporter
UM146_RS13315	COG0633	Ferredoxin
UM146_RS13315	COG3217	Mosc domain protein beta barrel domain protein
UM146_RS13330	COG0431	NADPH-dependent FMN reductase
UM146_RS13345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UM146_RS13355	COG0308	aminopeptidase N
UM146_RS13380	COG1448	Aminotransferase
UM146_RS13385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UM146_RS13390	COG3108	Peptidase M15
UM146_RS13395	COG2989	Protein conserved in bacteria
UM146_RS13405	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
UM146_RS13415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UM146_RS13420	COG1434	Gram-negative-bacterium-type cell wall biogenesis
UM146_RS13425	COG3173	Aminoglycoside phosphotransferase
UM146_RS13440	COG3214	Protein conserved in bacteria
UM146_RS13455	COG2333	competence protein COMEC
UM146_RS13455	COG0658	competence protein
UM146_RS13465	COG0539	negative regulation of cytoplasmic translation
UM146_RS13475	COG0501	Belongs to the peptidase M48B family
UM146_RS13490	COG2323	membrane
UM146_RS13495	COG1944	ATP diphosphatase activity
UM146_RS13500	COG2116	formate transmembrane transporter activity
UM146_RS13505	COG1882	Formate acetyltransferase
UM146_RS13510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
UM146_RS13520	COG1335	isochorismatase
UM146_RS13525	COG3302	dmso reductase anchor subunit
UM146_RS13530	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS13535	COG0243	molybdopterin cofactor binding
UM146_RS13545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UM146_RS13555	COG1674	ftsk spoiiie
UM146_RS13555	COG1178	ABC-type Fe3 transport system permease component
UM146_RS13560	COG1522	sequence-specific DNA binding
UM146_RS13565	COG0492	ferredoxin-NADP+ reductase activity
UM146_RS13570	COG4988	ABC transporter
UM146_RS13575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UM146_RS13615	COG1203	CRISPR-associated helicase, Cas3
UM146_RS13620	COG1518	maintenance of DNA repeat elements
UM146_RS13625	COG0542	response to heat
UM146_RS13645	COG4220	transposase activity
UM146_RS13710	COG3311	Transcriptional regulator
UM146_RS13720	COG1278	Cold shock
UM146_RS13730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UM146_RS13735	COG2990	Protein conserved in bacteria
UM146_RS13740	COG3593	DNA synthesis involved in DNA repair
UM146_RS13755	COG2431	L-lysine efflux transmembrane transporter activity
UM146_RS13765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UM146_RS13770	COG0028	Belongs to the TPP enzyme family
UM146_RS13775	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
UM146_RS13780	COG0702	epimerase
UM146_RS13785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UM146_RS13790	COG3023	N-Acetylmuramoyl-L-alanine amidase
UM146_RS13805	COG1126	abc transporter atp-binding protein
UM146_RS13810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS13815	COG4215	(ABC) transporter
UM146_RS13820	COG4160	amino acid transport
UM146_RS13825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS13840	COG1177	transmembrane transport
UM146_RS13845	COG1176	ABC-type spermidine putrescine transport system, permease component I
UM146_RS13850	COG3842	ATPase activity
UM146_RS13855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
UM146_RS13875	COG0778	Nitroreductase
UM146_RS13885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
UM146_RS13900	COG3226	Transcriptional regulator
UM146_RS13905	COG0738	Major facilitator superfamily
UM146_RS13910	COG0561	phosphatase activity
UM146_RS13920	COG2814	Major facilitator Superfamily
UM146_RS13925	COG0671	phosphoesterase, PA-phosphatase related
UM146_RS13930	COG1349	DNA-binding transcription factor activity
UM146_RS13935	COG1686	Belongs to the peptidase S11 family
UM146_RS13940	COG0625	glutathione transferase activity
UM146_RS13945	COG2133	pyrroloquinoline quinone binding
UM146_RS13960	COG2199	diguanylate cyclase activity
UM146_RS13965	COG2200	EAL domain
UM146_RS13990	COG1446	asparaginase
UM146_RS13995	COG0303	'Molybdopterin
UM146_RS14000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UM146_RS14005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UM146_RS14010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
UM146_RS14015	COG1882	Formate acetyltransferase
UM146_RS14020	COG0561	phosphatase activity
UM146_RS14025	COG0488	(ABC) transporter
UM146_RS14030	COG1376	ErfK ybiS ycfS ynhG family protein
UM146_RS14035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UM146_RS14040	COG1321	iron dependent repressor
UM146_RS14050	COG2194	sulfuric ester hydrolase activity
UM146_RS14055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
UM146_RS14060	COG5006	permease, DMT superfamily
UM146_RS14075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS14080	COG0765	amino acid transport
UM146_RS14085	COG1126	abc transporter atp-binding protein
UM146_RS14090	COG0668	transmembrane transport
UM146_RS14115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UM146_RS14125	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
UM146_RS14130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UM146_RS14135	COG1199	ATP-dependent helicase activity
UM146_RS14145	COG0513	Belongs to the DEAD box helicase family
UM146_RS14150	COG1309	transcriptional regulator
UM146_RS14160	COG1131	(ABC) transporter
UM146_RS14165	COG0842	Transport permease protein
UM146_RS14170	COG0842	Transport permease protein
UM146_RS14180	COG3568	Endonuclease Exonuclease Phosphatase
UM146_RS14185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UM146_RS14190	COG0392	lysyltransferase activity
UM146_RS14195	COG0670	Belongs to the BI1 family
UM146_RS14200	COG0670	Belongs to the BI1 family
UM146_RS14205	COG0314	molybdopterin synthase activity
UM146_RS14210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
UM146_RS14220	COG0521	Mo-molybdopterin cofactor biosynthetic process
UM146_RS14235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UM146_RS14245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UM146_RS14250	COG2226	methyltransferase
UM146_RS14265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UM146_RS14270	COG1881	PFAM PEBP family protein
UM146_RS14275	COG4677	pectinesterase activity
UM146_RS14280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UM146_RS14285	COG0471	metal ion transport
UM146_RS14290	COG2828	Protein conserved in bacteria
UM146_RS14295	COG0583	DNA-binding transcription factor activity
UM146_RS14305	COG0561	phosphatase activity
UM146_RS14315	COG4149	molybdate abc transporter
UM146_RS14320	COG0725	ABC transporter, periplasmic molybdate-binding protein
UM146_RS14330	COG2005	Transcriptional regulator
UM146_RS14330	COG3585	molybdate ion transport
UM146_RS14340	COG1119	ATPase activity
UM146_RS14345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UM146_RS14350	COG1085	galactose-1-phosphate uridylyltransferase
UM146_RS14360	COG2017	converts alpha-aldose to the beta-anomer
UM146_RS14370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
UM146_RS14385	COG1230	cation diffusion facilitator family transporter
UM146_RS14390	COG3201	nicotinamide mononucleotide transporter
UM146_RS14415	COG2885	chlorophyll binding
UM146_RS14425	COG3064	Membrane
UM146_RS14430	COG0848	biopolymer transport protein
UM146_RS14435	COG0811	peptide transport
UM146_RS14440	COG0824	Thioesterase
UM146_RS14445	COG3790	cyd operon protein YbgE
UM146_RS14450	COG4890	Cyd operon protein YbgT
UM146_RS14455	COG1294	oxidase, subunit
UM146_RS14460	COG1271	oxidase subunit
UM146_RS14475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UM146_RS14485	COG0508	dehydrogenase complex catalyzes the overall conversion of
UM146_RS14490	COG0567	Dehydrogenase, E1 component
UM146_RS14500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UM146_RS14505	COG1053	succinate dehydrogenase
UM146_RS14510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
UM146_RS14515	COG2009	succinate dehydrogenase
UM146_RS14525	COG0372	Belongs to the citrate synthase family
UM146_RS14530	COG3539	Fimbrial protein
UM146_RS14535	COG3180	Ammonia monooxygenase
UM146_RS14550	COG1984	allophanate hydrolase subunit 2
UM146_RS14555	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UM146_RS14560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UM146_RS14570	COG0415	Belongs to the DNA photolyase family
UM146_RS14575	COG3272	Protein of unknown function (DUF1722)
UM146_RS14605	COG2205	protein histidine kinase activity
UM146_RS14610	COG0745	RESPONSE REGULATOR receiver
UM146_RS14620	COG1982	Orn Lys Arg decarboxylase major
UM146_RS14625	COG0531	amino acid
UM146_RS14630	COG0033	Phosphoglucomutase
UM146_RS14635	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
UM146_RS14640	COG0596	Alpha beta hydrolase
UM146_RS14650	COG0716	FMN binding
UM146_RS14665	COG0735	belongs to the Fur family
UM146_RS14690	COG1349	DNA-binding transcription factor activity
UM146_RS14695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UM146_RS14700	COG3395	kinase activity
UM146_RS14705	COG1454	alcohol dehydrogenase
UM146_RS14710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UM146_RS14735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS14735	COG1263	PTS System
UM146_RS14735	COG2190	(PTS) system
UM146_RS14745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UM146_RS14750	COG1846	Transcriptional regulator
UM146_RS14750	COG1940	carbohydrate kinase activity
UM146_RS14755	COG0647	UMP catabolic process
UM146_RS14760	COG0367	asparagine synthase
UM146_RS14800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UM146_RS14810	COG1702	phosphate starvation-inducible protein PhoH
UM146_RS14820	COG4535	Mg2 and Co2 transporter CorC
UM146_RS14825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
UM146_RS14835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UM146_RS14840	COG0765	amino acid transport
UM146_RS14845	COG0765	amino acid transport
UM146_RS14850	COG1126	abc transporter atp-binding protein
UM146_RS14860	COG2888	peptidyl-tyrosine sulfation
UM146_RS14875	COG1466	dna polymerase III delta subunit
UM146_RS14885	COG0406	alpha-ribazole phosphatase activity
UM146_RS14890	COG0799	negative regulation of ribosome biogenesis
UM146_RS14900	COG0768	penicillin binding
UM146_RS14905	COG0772	Belongs to the SEDS family
UM146_RS14910	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UM146_RS14915	COG1686	Belongs to the peptidase S11 family
UM146_RS14940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UM146_RS14945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UM146_RS14965	COG3069	C4-dicarboxylate transmembrane transporter activity
UM146_RS14970	COG4565	transcriptional regulatory protein
UM146_RS14975	COG3290	protein histidine kinase activity
UM146_RS14980	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
UM146_RS14990	COG2301	Belongs to the HpcH HpaI aldolase family
UM146_RS14995	COG3051	citrate lyase alpha subunit
UM146_RS15010	COG0471	metal ion transport
UM146_RS15015	COG3719	Belongs to the RNase T2 family
UM146_RS15020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UM146_RS15025	COG0589	response to stress
UM146_RS15030	COG3634	alkyl hydroperoxide reductase activity
UM146_RS15035	COG0450	alkyl hydroperoxide reductase
UM146_RS15040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UM146_RS15045	COG0583	DNA-binding transcription factor activity
UM146_RS15050	COG3969	phosphoadenosine phosphosulfate
UM146_RS15055	COG1475	DNA binding
UM146_RS15060	COG0436	Aminotransferase
UM146_RS15065	COG0371	Dehydrogenase
UM146_RS15070	COG2879	small protein
UM146_RS15075	COG1966	Carbon starvation protein
UM146_RS15080	COG2050	protein possibly involved in aromatic compounds catabolism
UM146_RS15085	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS15090	COG3433	isochorismatase activity
UM146_RS15090	COG1535	isochorismatase
UM146_RS15095	COG1021	2,3-dihydroxybenzoate-AMP ligase
UM146_RS15100	COG1169	isochorismate synthase
UM146_RS15105	COG4592	Periplasmic binding protein
UM146_RS15115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM146_RS15120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM146_RS15125	COG1120	ATPase activity
UM146_RS15130	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
UM146_RS15135	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
UM146_RS15135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UM146_RS15140	COG3251	PFAM MbtH domain protein
UM146_RS15145	COG2382	esterase
UM146_RS15150	COG4771	TonB-dependent receptor
UM146_RS15160	COG2977	Belongs to the P-Pant transferase superfamily
UM146_RS15190	COG2315	Protein conserved in bacteria
UM146_RS15200	COG0668	transmembrane transport
UM146_RS15205	COG1113	amino acid transport
UM146_RS15210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UM146_RS15215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UM146_RS15220	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UM146_RS15225	COG1538	Outer membrane efflux protein
UM146_RS15230	COG0745	RESPONSE REGULATOR receiver
UM146_RS15235	COG5002	protein histidine kinase activity
UM146_RS15240	COG1215	transferase activity, transferring glycosyl groups
UM146_RS15245	COG4783	chaperone-mediated protein folding
UM146_RS15255	COG4571	Outer membrane protease
UM146_RS15260	COG0500	methyltransferase
UM146_RS15265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
UM146_RS15270	COG0582	viral genome integration into host DNA
UM146_RS15275	COG0582	viral genome integration into host DNA
UM146_RS15290	COG2501	S4 domain
UM146_RS15295	COG1988	membrane-bound metal-dependent
UM146_RS15305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UM146_RS15320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UM146_RS15325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
UM146_RS15330	COG0549	Belongs to the carbamate kinase family
UM146_RS15340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UM146_RS15345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UM146_RS15350	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
UM146_RS15355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UM146_RS15360	COG3257	ureidoglycine aminohydrolase activity
UM146_RS15365	COG1929	Belongs to the glycerate kinase type-1 family
UM146_RS15370	COG2233	PERMEase
UM146_RS15380	COG1953	Uracil, thiamine, allantoin
UM146_RS15385	COG2084	Dehydrogenase
UM146_RS15390	COG3622	Belongs to the hyi family
UM146_RS15395	COG3960	tartronate-semialdehyde synthase activity
UM146_RS15420	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
UM146_RS15425	COG4181	ATPase activity
UM146_RS15430	COG2755	lipolytic protein G-D-S-L family
UM146_RS15435	COG0300	oxidoreductase activity
UM146_RS15440	COG3118	belongs to the thioredoxin family
UM146_RS15445	COG0390	transport system, permease component
UM146_RS15450	COG4619	ABC transporter
UM146_RS15455	COG0330	HflC and HflK could
UM146_RS15460	COG1585	Membrane protein implicated in regulation of membrane protease activity
UM146_RS15485	COG0789	Transcriptional regulator
UM146_RS15490	COG0531	amino acid
UM146_RS15495	COG2066	Belongs to the glutaminase family
UM146_RS15500	COG2217	Heavy metal translocating P-type atpase
UM146_RS15505	COG3093	addiction module antidote protein HigA
UM146_RS15510	COG3549	Plasmid maintenance system killer
UM146_RS15515	COG3735	TraB family
UM146_RS15535	COG0737	Belongs to the 5'-nucleotidase family
UM146_RS15540	COG2223	nitrite transmembrane transporter activity
UM146_RS15545	COG4651	solute:proton antiporter activity
UM146_RS15545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UM146_RS15550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS15585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UM146_RS15595	COG2832	Protein of unknown function (DUF454)
UM146_RS15600	COG3923	Primosomal replication protein n
UM146_RS15615	COG3264	Mechanosensitive ion channel
UM146_RS15615	COG1196	nuclear chromosome segregation
UM146_RS15620	COG1309	transcriptional regulator
UM146_RS15625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UM146_RS15630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UM146_RS15645	COG0110	maltose O-acetyltransferase activity
UM146_RS15655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
UM146_RS15660	COG5507	3-demethylubiquinone-9 3-methyltransferase
UM146_RS15665	COG3695	enzyme binding
UM146_RS15670	COG3126	Type III secretion system lipoprotein chaperone (YscW)
UM146_RS15675	COG1946	Acyl-CoA thioesterase
UM146_RS15680	COG0004	ammonium transporteR
UM146_RS15685	COG0347	Belongs to the P(II) protein family
UM146_RS15690	COG1132	(ABC) transporter
UM146_RS15695	COG1132	(ABC) transporter
UM146_RS15700	COG1522	sequence-specific DNA binding
UM146_RS15710	COG4533	DNA binding
UM146_RS15720	COG0824	Thioesterase
UM146_RS15725	COG1555	photosystem II stabilization
UM146_RS15730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UM146_RS15735	COG0776	regulation of translation
UM146_RS15740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UM146_RS15765	COG0271	Belongs to the BolA IbaG family
UM146_RS15770	COG3056	Lipoprotein
UM146_RS15775	COG2223	nitrite transmembrane transporter activity
UM146_RS15780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UM146_RS15785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UM146_RS15790	COG1845	cytochrome c oxidase, subunit III
UM146_RS15795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
UM146_RS15805	COG2814	Major facilitator Superfamily
UM146_RS15815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UM146_RS15820	COG0693	protein deglycase activity
UM146_RS15835	COG0142	geranyltranstransferase activity
UM146_RS15845	COG0667	Aldo Keto reductase
UM146_RS15850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UM146_RS15855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
UM146_RS15870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UM146_RS15870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UM146_RS15880	COG4238	major outer membrane lipoprotein
UM146_RS15885	COG3248	Nucleoside-binding outer membrane protein
UM146_RS15890	COG1403	HNH endonuclease
UM146_RS15895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UM146_RS15900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UM146_RS15905	COG1862	Preprotein translocase
UM146_RS15925	COG0366	Alpha amylase catalytic
UM146_RS15930	COG1113	amino acid transport
UM146_RS15935	COG1114	Component of the transport system for branched-chain amino acids
UM146_RS15940	COG5002	protein histidine kinase activity
UM146_RS15945	COG0745	RESPONSE REGULATOR receiver
UM146_RS15950	COG0420	3'-5' exonuclease activity
UM146_RS15955	COG0419	ATPase involved in DNA repair
UM146_RS15960	COG2814	Major facilitator Superfamily
UM146_RS15965	COG1940	carbohydrate kinase activity
UM146_RS15985	COG4126	flavin adenine dinucleotide binding
UM146_RS16010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UM146_RS16015	COG3706	GGDEF domain
UM146_RS16025	COG1785	Belongs to the alkaline phosphatase family
UM146_RS16035	COG1181	Belongs to the D-alanine--D-alanine ligase family
UM146_RS16055	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
UM146_RS16065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UM146_RS16070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UM146_RS16080	COG0113	porphobilinogen synthase activity
UM146_RS16085	COG2175	clavaminate synthase activity
UM146_RS16090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UM146_RS16100	COG4521	taurine ABC transporter
UM146_RS16105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UM146_RS16110	COG1215	transferase activity, transferring glycosyl groups
UM146_RS16140	COG3122	Protein conserved in bacteria
UM146_RS16145	COG1609	Transcriptional regulator
UM146_RS16155	COG2223	nitrite transmembrane transporter activity
UM146_RS16160	COG0110	maltose O-acetyltransferase activity
UM146_RS16165	COG0402	S-adenosylhomocysteine deaminase activity
UM146_RS16170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
UM146_RS16175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UM146_RS16180	COG2079	MmgE PrpD family protein
UM146_RS16190	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
UM146_RS16195	COG3829	transcription factor binding
UM146_RS16200	COG3829	transcription factor binding
UM146_RS16210	COG1280	lysine exporter protein (LysE YggA)
UM146_RS16220	COG1064	alcohol dehydrogenase
UM146_RS16230	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS16235	COG1129	ABC transporter
UM146_RS16240	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS16250	COG0402	S-adenosylhomocysteine deaminase activity
UM146_RS16255	COG0549	Belongs to the carbamate kinase family
UM146_RS16260	COG1304	FMN binding
UM146_RS16265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UM146_RS16275	COG0666	response to abiotic stimulus
UM146_RS16285	COG0583	DNA-binding transcription factor activity
UM146_RS16290	COG2200	EAL domain
UM146_RS16290	COG2771	luxR family
UM146_RS16300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
UM146_RS16325	COG0582	viral genome integration into host DNA
UM146_RS16330	COG2200	EAL domain
UM146_RS16330	COG2771	luxR family
UM146_RS16340	COG3468	outer membrane autotransporter barrel domain protein
UM146_RS16355	COG1556	Lactate utilization protein
UM146_RS16360	COG1139	Iron-sulfur cluster binding protein
UM146_RS16365	COG0247	lactate metabolic process
UM146_RS16370	COG2207	Transcriptional regulator
UM146_RS16375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UM146_RS16385	COG3059	membrane
UM146_RS16390	COG0656	L-ascorbic acid biosynthetic process
UM146_RS16395	COG3708	Transcriptional regulator
UM146_RS16395	COG2207	Transcriptional regulator
UM146_RS16400	COG1388	LysM domain
UM146_RS16405	COG0656	L-ascorbic acid biosynthetic process
UM146_RS16410	COG0667	Aldo Keto reductase
UM146_RS16420	COG0583	DNA-binding transcription factor activity
UM146_RS16425	COG1073	alpha beta
UM146_RS16430	COG1902	pentaerythritol trinitrate reductase activity
UM146_RS16480	COG0727	PFAM Uncharacterised protein family (UPF0153)
UM146_RS16485	COG3477	response to acidic pH
UM146_RS16525	COG0582	viral genome integration into host DNA
UM146_RS16560	COG0210	DNA helicase
UM146_RS16595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
UM146_RS16615	COG2195	Cleaves the N-terminal amino acid of tripeptides
UM146_RS16620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UM146_RS16625	COG1690	Belongs to the RtcB family
UM146_RS16630	COG0454	-acetyltransferase
UM146_RS16640	COG2161	toxin-antitoxin pair type II binding
UM146_RS16660	COG1943	Transposase
UM146_RS16665	COG0791	NLP P60 protein
UM146_RS16670	COG3034	peptidoglycan biosynthetic process
UM146_RS16675	COG0121	glutamine amidotransferase
UM146_RS16685	COG1960	acyl-CoA dehydrogenase activity
UM146_RS16695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UM146_RS16710	COG5433	transposase activity
UM146_RS16715	COG5433	transposase activity
UM146_RS16735	COG3501	Rhs element vgr protein
UM146_RS16835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UM146_RS16845	COG2226	methyltransferase
UM146_RS16860	COG2226	methyltransferase
UM146_RS16870	COG0583	DNA-binding transcription factor activity
UM146_RS16875	COG0656	L-ascorbic acid biosynthetic process
UM146_RS16910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UM146_RS16930	COG0551	DNA topoisomerase type I activity
UM146_RS16940	COG0758	DNA mediated transformation
UM146_RS16960	COG0569	domain protein
UM146_RS16970	COG3036	rescue of stalled ribosome
UM146_RS16975	COG0789	Transcriptional regulator
UM146_RS17015	COG0201	protein transport
UM146_RS17090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UM146_RS17105	COG0089	rRNA binding
UM146_RS17130	COG3267	Type II secretory pathway component ExeA
UM146_RS17130	COG3409	Peptidoglycan-binding domain 1 protein
UM146_RS17135	COG3031	protein transport across the cell outer membrane
UM146_RS17140	COG1450	Type ii and iii secretion system protein
UM146_RS17145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UM146_RS17150	COG1459	type II secretion system
UM146_RS17155	COG2165	general secretion pathway protein
UM146_RS17160	COG2165	general secretion pathway protein
UM146_RS17165	COG2165	general secretion pathway protein
UM146_RS17170	COG4795	General secretion pathway protein
UM146_RS17175	COG3156	type II secretion system protein K
UM146_RS17180	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
UM146_RS17185	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
UM146_RS17190	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
UM146_RS17195	COG2193	ferroxidase activity
UM146_RS17200	COG2906	2 iron, 2 sulfur cluster binding
UM146_RS17205	COG3979	chitinase
UM146_RS17245	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
UM146_RS17245	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
UM146_RS17250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UM146_RS17280	COG0151	Belongs to the GarS family
UM146_RS17290	COG4191	Histidine kinase
UM146_RS17295	COG3678	ATP-independent chaperone mediated protein folding
UM146_RS17310	COG3068	Protein conserved in bacteria
UM146_RS17345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UM146_RS17350	COG2104	thiamine diphosphate biosynthetic process
UM146_RS17360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UM146_RS17395	COG0250	Participates in transcription elongation, termination and antitermination
UM146_RS17400	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UM146_RS17440	COG2964	Protein conserved in bacteria
UM146_RS17445	COG0545	Peptidyl-prolyl cis-trans isomerase
UM146_RS17455	COG1047	Peptidyl-prolyl cis-trans
UM146_RS17460	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
UM146_RS17475	COG0488	(ABC) transporter
UM146_RS17480	COG0429	hydrolase of the alpha beta-hydrolase fold
UM146_RS17490	COG3954	Phosphoribulokinase
UM146_RS17495	COG1765	OsmC-like protein
UM146_RS17505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UM146_RS17510	COG1289	transmembrane transporter activity
UM146_RS17515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UM146_RS17520	COG0512	Glutamine amidotransferase of anthranilate synthase
UM146_RS17525	COG2184	nucleotidyltransferase activity
UM146_RS17545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UM146_RS17550	COG2146	nitrite reductase [NAD(P)H] activity
UM146_RS17555	COG2116	formate transmembrane transporter activity
UM146_RS17570	COG0626	cystathionine gamma-synthase activity
UM146_RS17585	COG1735	metal-dependent hydrolase with the TIM-barrel fold
UM146_RS17590	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
UM146_RS17595	COG3457	Alanine racemase
UM146_RS17605	COG2188	Transcriptional regulator
UM146_RS17610	COG0180	Tryptophanyl-tRNA synthetase
UM146_RS17615	COG0546	phosphoglycolate phosphatase activity
UM146_RS17620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UM146_RS17625	COG0338	D12 class N6 adenine-specific DNA methyltransferase
UM146_RS17630	COG3266	domain, Protein
UM146_RS17645	COG4796	Type ii and iii secretion system protein
UM146_RS17660	COG3166	PFAM Fimbrial assembly family protein
UM146_RS17665	COG4972	Pilus assembly protein
UM146_RS17670	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
UM146_RS17675	COG0494	nUDIX hydrolase
UM146_RS17685	COG1011	Hydrolase
UM146_RS17690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UM146_RS17700	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
UM146_RS17725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UM146_RS17730	COG2183	response to ionizing radiation
UM146_RS17735	COG1918	ferrous iron import across plasma membrane
UM146_RS17740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UM146_RS17750	COG5464	transposase or invertase
UM146_RS17760	COG1040	competence protein
UM146_RS17770	COG2610	gluconate transmembrane transporter activity
UM146_RS17775	COG1640	4-alpha-glucanotransferase
UM146_RS17780	COG0058	SHG alpha-glucan phosphorylase activity
UM146_RS17795	COG1690	Belongs to the RtcB family
UM146_RS17800	COG4650	regulator
UM146_RS17805	COG1349	DNA-binding transcription factor activity
UM146_RS17820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UM146_RS17860	COG3188	usher protein
UM146_RS17875	COG0058	SHG alpha-glucan phosphorylase activity
UM146_RS17900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UM146_RS17905	COG2095	MarC family integral membrane protein
UM146_RS17910	COG2610	gluconate transmembrane transporter activity
UM146_RS17915	COG3265	gluconokinase activity
UM146_RS17920	COG1609	Transcriptional regulator
UM146_RS17925	COG1741	Belongs to the pirin family
UM146_RS17930	COG0673	inositol 2-dehydrogenase activity
UM146_RS17935	COG1247	-acetyltransferase
UM146_RS17955	COG0405	Gamma-glutamyltransferase
UM146_RS17965	COG0584	glycerophosphoryl diester phosphodiesterase
UM146_RS17995	COG0410	ABC transporter
UM146_RS18000	COG0411	ABC transporter
UM146_RS18005	COG4177	L-phenylalanine transmembrane transporter activity
UM146_RS18010	COG0559	Belongs to the binding-protein-dependent transport system permease family
UM146_RS18015	COG0683	leucine binding
UM146_RS18020	COG0456	acetyltransferase
UM146_RS18030	COG0683	leucine binding
UM146_RS18055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UM146_RS18060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UM146_RS18065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UM146_RS18070	COG2177	Part of the ABC transporter FtsEX involved in
UM146_RS18075	COG2884	Cell division ATP-binding protein ftsE
UM146_RS18080	COG0552	protein localization to endoplasmic reticulum
UM146_RS18085	COG0742	ribosomal rna small subunit methyltransferase
UM146_RS18090	COG3776	membrane
UM146_RS18100	COG3714	YhhN family
UM146_RS18115	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
UM146_RS18125	COG0477	Major facilitator Superfamily
UM146_RS18130	COG0628	permease
UM146_RS18135	COG2091	lysine biosynthetic process via aminoadipic acid
UM146_RS18140	COG0747	negative chemotaxis
UM146_RS18145	COG0601	transmembrane transport
UM146_RS18150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UM146_RS18170	COG2188	Transcriptional regulator
UM146_RS18180	COG3414	Phosphotransferase system galactitol-specific IIB component
UM146_RS18185	COG3775	system Galactitol-specific IIC component
UM146_RS18200	COG0191	fructose-bisphosphate aldolase activity
UM146_RS18205	COG0842	Transport permease protein
UM146_RS18210	COG0842	Transport permease protein
UM146_RS18210	COG1129	ABC transporter
UM146_RS18215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UM146_RS18225	COG2081	HI0933 family
UM146_RS18230	COG0306	phosphate transporter
UM146_RS18240	COG0589	response to stress
UM146_RS18245	COG3104	oligopeptide transport
UM146_RS18255	COG0339	signal peptide processing
UM146_RS18260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
UM146_RS18265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UM146_RS18280	COG1393	Belongs to the ArsC family
UM146_RS18285	COG3065	identical protein binding
UM146_RS18290	COG2197	response regulator
UM146_RS18295	COG3720	iron ion transport
UM146_RS18300	COG4771	TonB-dependent receptor
UM146_RS18320	COG3721	Heme iron utilization protein
UM146_RS18330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM146_RS18340	COG1285	pathogenesis
UM146_RS18355	COG3247	response to pH
UM146_RS18360	COG2771	luxR family
UM146_RS18370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UM146_RS18375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UM146_RS18380	COG2207	Transcriptional regulator
UM146_RS18385	COG2207	Transcriptional regulator
UM146_RS18390	COG0076	glutamate decarboxylase activity
UM146_RS18395	COG1858	cytochrome C peroxidase
UM146_RS18405	COG2197	response regulator
UM146_RS18410	COG0583	DNA-binding transcription factor activity
UM146_RS18415	COG1295	ribonuclease BN
UM146_RS18420	COG0477	Major facilitator Superfamily
UM146_RS18425	COG2982	Protein involved in outer membrane biogenesis
UM146_RS18430	COG2200	EAL domain
UM146_RS18440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS18445	COG0612	Peptidase, M16
UM146_RS18455	COG2200	EAL domain
UM146_RS18455	COG2199	diguanylate cyclase activity
UM146_RS18460	COG3118	belongs to the thioredoxin family
UM146_RS18460	COG0457	Tetratricopeptide repeat
UM146_RS18465	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
UM146_RS18470	COG1215	transferase activity, transferring glycosyl groups
UM146_RS18475	COG1215	transferase activity, transferring glycosyl groups
UM146_RS18500	COG2194	sulfuric ester hydrolase activity
UM146_RS18525	COG0814	amino acid
UM146_RS18530	COG4608	Belongs to the ABC transporter superfamily
UM146_RS18535	COG0444	Belongs to the ABC transporter superfamily
UM146_RS18540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UM146_RS18545	COG0601	transmembrane transport
UM146_RS18555	COG0747	negative chemotaxis
UM146_RS18570	COG2194	sulfuric ester hydrolase activity
UM146_RS18575	COG2223	nitrite transmembrane transporter activity
UM146_RS18580	COG5571	outer membrane autotransporter
UM146_RS18585	COG2818	Glycosylase
UM146_RS18590	COG0456	acetyltransferase
UM146_RS18595	COG0243	molybdopterin cofactor binding
UM146_RS18600	COG2885	chlorophyll binding
UM146_RS18615	COG2944	sequence-specific DNA binding
UM146_RS18620	COG1278	Cold shock
UM146_RS18645	COG3274	enterobacterial common antigen metabolic process
UM146_RS18650	COG4682	membrane
UM146_RS18655	COG4682	membrane
UM146_RS18660	COG1070	Carbohydrate kinase
UM146_RS18670	COG4213	ABC transporter substrate-binding protein
UM146_RS18680	COG4214	carbohydrate transport
UM146_RS18685	COG1609	Transcriptional regulator
UM146_RS18685	COG2207	Transcriptional regulator
UM146_RS18690	COG2992	FlgJ-related protein
UM146_RS18695	COG0366	Alpha amylase catalytic
UM146_RS18700	COG3977	Valine--pyruvate aminotransferase
UM146_RS18710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
UM146_RS18715	COG1414	Transcriptional regulator
UM146_RS18725	COG2731	YhcH YjgK YiaL family protein
UM146_RS18735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
UM146_RS18740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UM146_RS18750	COG1070	Carbohydrate kinase
UM146_RS18755	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
UM146_RS18760	COG3623	hexulose-6-phosphate isomerase
UM146_RS18765	COG0235	Class ii aldolase
UM146_RS18770	COG1012	belongs to the aldehyde dehydrogenase family
UM146_RS18780	COG1454	alcohol dehydrogenase
UM146_RS18785	COG3276	selenocysteine insertion sequence binding
UM146_RS18795	COG0625	glutathione transferase activity
UM146_RS18800	COG1566	PFAM secretion protein HlyD family protein
UM146_RS18810	COG2213	PTS system mannitol-specific
UM146_RS18810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS18825	COG3722	fumarate hydratase activity
UM146_RS18845	COG5295	Hep Hag repeat protein
UM146_RS18850	COG1620	l-lactate permease
UM146_RS18855	COG2186	Transcriptional regulator
UM146_RS18865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UM146_RS18870	COG1045	serine acetyltransferase
UM146_RS18885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
UM146_RS18890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UM146_RS18900	COG4942	peptidase
UM146_RS18905	COG2861	carbohydrate metabolic process
UM146_RS18910	COG1216	Glycosyl transferase, family 2
UM146_RS18920	COG0156	8-amino-7-oxononanoate synthase activity
UM146_RS18930	COG0859	PFAM glycosyl transferase family 9
UM146_RS18935	COG0859	PFAM glycosyl transferase family 9
UM146_RS18940	COG3307	-O-antigen
UM146_RS18950	COG1442	glycosyl transferase family 8
UM146_RS18955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UM146_RS18970	COG0515	serine threonine protein kinase
UM146_RS18975	COG0438	transferase activity, transferring glycosyl groups
UM146_RS18980	COG0859	PFAM glycosyl transferase family 9
UM146_RS18985	COG1519	Transferase
UM146_RS19015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UM146_RS19040	COG1561	YicC-like family, N-terminal region
UM146_RS19045	COG3645	SOS response
UM146_RS19050	COG2860	membrane
UM146_RS19070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UM146_RS19075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UM146_RS19080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UM146_RS19085	COG0786	glutamate:sodium symporter activity
UM146_RS19090	COG2233	PERMEase
UM146_RS19095	COG2982	Protein involved in outer membrane biogenesis
UM146_RS19105	COG1940	carbohydrate kinase activity
UM146_RS19120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS19120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS19125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS19130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS19130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS19130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS19135	COG3711	transcriptional antiterminator
UM146_RS19140	COG1501	Belongs to the glycosyl hydrolase 31 family
UM146_RS19145	COG2211	Major facilitator Superfamily
UM146_RS19175	COG1464	Belongs to the NlpA lipoprotein family
UM146_RS19200	COG2252	PERMEase
UM146_RS19210	COG2271	Major facilitator Superfamily
UM146_RS19215	COG2271	Major facilitator Superfamily
UM146_RS19220	COG3851	Histidine kinase
UM146_RS19225	COG2197	response regulator
UM146_RS19230	COG0440	acetolactate synthase activity
UM146_RS19235	COG0028	Belongs to the TPP enzyme family
UM146_RS19245	COG2814	Major facilitator Superfamily
UM146_RS19250	COG0641	radical SAM
UM146_RS19260	COG2149	membrane
UM146_RS19270	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UM146_RS19275	COG2207	Transcriptional regulator
UM146_RS19300	COG5645	(Lipo)protein
UM146_RS19305	COG0823	Involved in the tonB-independent uptake of proteins
UM146_RS19315	COG2271	Major facilitator Superfamily
UM146_RS19325	COG0800	Aldolase
UM146_RS19330	COG3734	2-keto-3-deoxy-galactonokinase
UM146_RS19335	COG2186	Transcriptional regulator
UM146_RS19345	COG0561	phosphatase activity
UM146_RS19350	COG3753	Protein conserved in bacteria
UM146_RS19360	COG0187	DNA topoisomerase II activity
UM146_RS19370	COG0592	DNA-directed DNA polymerase activity
UM146_RS19415	COG0814	amino acid
UM146_RS19425	COG0583	DNA-binding transcription factor activity
UM146_RS19430	COG2091	lysine biosynthetic process via aminoadipic acid
UM146_RS19435	COG0431	NADPH-dependent FMN reductase
UM146_RS19440	COG2252	PERMEase
UM146_RS19455	COG0363	glucosamine-6-phosphate deaminase activity
UM146_RS19460	COG2382	esterase
UM146_RS19470	COG2723	6-phospho-beta-galactosidase activity
UM146_RS19475	COG2190	(PTS) system
UM146_RS19475	COG1263	PTS System
UM146_RS19475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS19480	COG3711	transcriptional antiterminator
UM146_RS19485	COG0704	Plays a role in the regulation of phosphate uptake
UM146_RS19490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UM146_RS19495	COG0581	inorganic phosphate transmembrane transporter activity
UM146_RS19500	COG0573	inorganic phosphate transmembrane transporter activity
UM146_RS19505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UM146_RS19560	COG3312	ion transport
UM146_RS19575	COG0716	FMN binding
UM146_RS19580	COG1522	sequence-specific DNA binding
UM146_RS19615	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS19620	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS19625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS19630	COG1609	Transcriptional regulator
UM146_RS19635	COG0477	Major facilitator Superfamily
UM146_RS19640	COG2186	Transcriptional regulator
UM146_RS19680	COG3085	chromosome segregation
UM146_RS19685	COG0606	chelatase, subunit chli
UM146_RS19700	COG3978	acetolactate synthase activity
UM146_RS19705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UM146_RS19715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UM146_RS19720	COG0583	DNA-binding transcription factor activity
UM146_RS19730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UM146_RS19735	COG0210	DNA helicase
UM146_RS19750	COG3118	belongs to the thioredoxin family
UM146_RS19760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UM146_RS19770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UM146_RS19775	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
UM146_RS19780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UM146_RS19785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UM146_RS19790	COG1088	dTDP-glucose 4,6-dehydratase activity
UM146_RS19795	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
UM146_RS19800	COG0456	acetyltransferase
UM146_RS19805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UM146_RS19810	COG2244	polysaccharide biosynthetic process
UM146_RS19830	COG1113	amino acid transport
UM146_RS19855	COG0641	radical SAM
UM146_RS19860	COG3119	arylsulfatase activity
UM146_RS19865	COG3071	HemY protein
UM146_RS19870	COG2959	enzyme of heme biosynthesis
UM146_RS19875	COG1587	Uroporphyrinogen-III synthase
UM146_RS19885	COG3072	Adenylate cyclase
UM146_RS19905	COG5567	small periplasmic lipoprotein
UM146_RS19915	COG3159	Protein conserved in bacteria
UM146_RS19925	COG1011	Hydrolase
UM146_RS19930	COG0210	DNA helicase
UM146_RS19935	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
UM146_RS19940	COG3698	Phosphodiester glycosidase
UM146_RS19950	COG0598	Magnesium transport protein CorA
UM146_RS19965	COG2962	Rard protein
UM146_RS19970	COG2050	protein possibly involved in aromatic compounds catabolism
UM146_RS19975	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
UM146_RS19980	COG0514	ATP-dependent DNA helicase (RecQ)
UM146_RS19985	COG1280	lysine exporter protein (LysE YggA)
UM146_RS19990	COG1280	lysine exporter protein (LysE YggA)
UM146_RS19995	COG2267	carboxylic ester hydrolase activity
UM146_RS20000	COG0561	phosphatase activity
UM146_RS20005	COG0697	spore germination
UM146_RS20010	COG0583	DNA-binding transcription factor activity
UM146_RS20030	COG3157	Type VI secretion system effector, Hcp
UM146_RS20045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS20045	COG1263	PTS System
UM146_RS20045	COG2190	(PTS) system
UM146_RS20050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UM146_RS20060	COG0583	DNA-binding transcription factor activity
UM146_RS20065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
UM146_RS20075	COG0549	Belongs to the carbamate kinase family
UM146_RS20080	COG1304	FMN binding
UM146_RS20085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UM146_RS20095	COG1335	isochorismatase
UM146_RS20105	COG0412	Dienelactone hydrolase
UM146_RS20110	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
UM146_RS20130	COG0800	Aldolase
UM146_RS20135	COG3734	2-keto-3-deoxy-galactonokinase
UM146_RS20140	COG1414	Transcriptional regulator
UM146_RS20145	COG1322	Protein conserved in bacteria
UM146_RS20155	COG3165	ubiquinone biosynthetic process from chorismate
UM146_RS20165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UM146_RS20175	COG0805	protein transport
UM146_RS20190	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
UM146_RS20195	COG0543	2 iron, 2 sulfur cluster binding
UM146_RS20220	COG1739	Uncharacterized protein family UPF0029
UM146_RS20225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UM146_RS20230	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
UM146_RS20260	COG1763	Mo-molybdopterin cofactor biosynthetic process
UM146_RS20265	COG0746	molybdenum cofactor guanylyltransferase activity
UM146_RS20270	COG3084	Protein conserved in bacteria
UM146_RS20275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UM146_RS20280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UM146_RS20285	COG5339	Protein conserved in bacteria
UM146_RS20290	COG0204	Acyl-transferase
UM146_RS20300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UM146_RS20300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UM146_RS20315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UM146_RS20325	COG2204	response regulator
UM146_RS20330	COG3852	Histidine kinase
UM146_RS20335	COG0174	glutamine synthetase
UM146_RS20345	COG1217	gtp-binding protein TYPA
UM146_RS20350	COG1349	DNA-binding transcription factor activity
UM146_RS20355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UM146_RS20360	COG2084	Dehydrogenase
UM146_RS20365	COG3684	Belongs to the aldolase LacD family
UM146_RS20370	COG1063	alcohol dehydrogenase
UM146_RS20380	COG0477	Major facilitator Superfamily
UM146_RS20390	COG1011	Hydrolase
UM146_RS20405	COG0456	acetyltransferase
UM146_RS20415	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
UM146_RS20445	COG2864	formate dehydrogenase
UM146_RS20450	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS20455	COG3383	formate dehydrogenase (NAD+) activity
UM146_RS20455	COG0243	molybdopterin cofactor binding
UM146_RS20460	COG3383	formate dehydrogenase (NAD+) activity
UM146_RS20460	COG0243	molybdopterin cofactor binding
UM146_RS20525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UM146_RS20540	COG2258	MOSC domain
UM146_RS20545	COG2205	protein histidine kinase activity
UM146_RS20550	COG0745	RESPONSE REGULATOR receiver
UM146_RS20555	COG3678	ATP-independent chaperone mediated protein folding
UM146_RS20575	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
UM146_RS20595	COG3152	Membrane
UM146_RS20600	COG3691	Protein conserved in bacteria
UM146_RS20605	COG0589	response to stress
UM146_RS20615	COG1494	fructose-1,6-bisphosphatase
UM146_RS20640	COG1575	Belongs to the MenA family. Type 1 subfamily
UM146_RS20655	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UM146_RS20665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UM146_RS20675	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
UM146_RS20685	COG0626	cystathionine gamma-synthase activity
UM146_RS20690	COG0460	homoserine dehydrogenase
UM146_RS20690	COG0527	aspartate kinase activity
UM146_RS20700	COG0737	Belongs to the 5'-nucleotidase family
UM146_RS20705	COG0737	Belongs to the 5'-nucleotidase family
UM146_RS20715	COG0737	Belongs to the 5'-nucleotidase family
UM146_RS20720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UM146_RS20730	COG0697	spore germination
UM146_RS20735	COG3738	Protein conserved in bacteria
UM146_RS20745	COG0371	Dehydrogenase
UM146_RS20750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UM146_RS20755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS20755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UM146_RS20755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS20760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS20765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS20770	COG1882	Formate acetyltransferase
UM146_RS20775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
UM146_RS20780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UM146_RS20785	COG2207	Transcriptional regulator
UM146_RS20790	COG2194	sulfuric ester hydrolase activity
UM146_RS20805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UM146_RS20820	COG4948	Mandelate Racemase Muconate Lactonizing
UM146_RS20825	COG2271	Major facilitator Superfamily
UM146_RS20830	COG0583	DNA-binding transcription factor activity
UM146_RS20840	COG1473	amidohydrolase
UM146_RS20845	COG0477	Major facilitator Superfamily
UM146_RS20900	COG0456	acetyltransferase
UM146_RS20910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
UM146_RS20915	COG2224	Isocitrate lyase
UM146_RS20925	COG1414	Transcriptional regulator
UM146_RS20930	COG0646	methionine synthase
UM146_RS20930	COG1410	methionine synthase
UM146_RS20940	COG1283	sodium-dependent phosphate transmembrane transporter activity
UM146_RS20990	COG1187	pseudouridine synthase activity
UM146_RS21000	COG0527	aspartate kinase activity
UM146_RS21025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UM146_RS21045	COG3833	ABC-type maltose transport systems, permease component
UM146_RS21050	COG1175	transmembrane transport
UM146_RS21055	COG2182	Extracellular solute-binding protein
UM146_RS21065	COG3842	ATPase activity
UM146_RS21095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UM146_RS21105	COG0534	Mate efflux family protein
UM146_RS21110	COG3237	CsbD-like
UM146_RS21115	COG0735	belongs to the Fur family
UM146_RS21120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UM146_RS21130	COG0604	alcohol dehydrogenase
UM146_RS21135	COG1053	succinate dehydrogenase
UM146_RS21140	COG0477	Major facilitator Superfamily
UM146_RS21145	COG1024	Enoyl-CoA hydratase
UM146_RS21155	COG1609	Transcriptional regulator
UM146_RS21160	COG0305	Participates in initiation and elongation during chromosome replication
UM146_RS21165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UM146_RS21170	COG3201	nicotinamide mononucleotide transporter
UM146_RS21180	COG1448	Aminotransferase
UM146_RS21185	COG0567	Dehydrogenase, E1 component
UM146_RS21195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UM146_RS21200	COG0045	succinate-CoA ligase (ADP-forming) activity
UM146_RS21205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UM146_RS21210	COG0471	metal ion transport
UM146_RS21215	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
UM146_RS21220	COG2204	response regulator
UM146_RS21230	COG3700	Belongs to the class B bacterial acid phosphatase family
UM146_RS21235	COG0432	Pfam Uncharacterised protein family UPF0047
UM146_RS21240	COG2315	Protein conserved in bacteria
UM146_RS21245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UM146_RS21250	COG0629	single-stranded DNA binding
UM146_RS21260	COG4943	cyclic-guanylate-specific phosphodiesterase activity
UM146_RS21265	COG2207	Transcriptional regulator
UM146_RS21270	COG0789	Transcriptional regulator
UM146_RS21275	COG2252	PERMEase
UM146_RS21280	COG0025	NhaP-type Na H and K H
UM146_RS21285	COG0583	DNA-binding transcription factor activity
UM146_RS21290	COG1380	Effector of murein hydrolase LrgA
UM146_RS21295	COG1346	cytolysis
UM146_RS21305	COG3162	membrane
UM146_RS21310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UM146_RS21320	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
UM146_RS21325	COG0437	4 iron, 4 sulfur cluster binding
UM146_RS21330	COG3301	Polysulphide reductase, NrfD
UM146_RS21335	COG1138	Cytochrome C-type biogenesis protein
UM146_RS21340	COG3088	subunit of a heme lyase
UM146_RS21345	COG4235	cytochrome complex assembly
UM146_RS21350	COG1301	dicarboxylic acid transport
UM146_RS21355	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
UM146_RS21360	COG4608	Belongs to the ABC transporter superfamily
UM146_RS21365	COG0444	Belongs to the ABC transporter superfamily
UM146_RS21370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UM146_RS21375	COG0601	transmembrane transport
UM146_RS21385	COG3383	formate dehydrogenase (NAD+) activity
UM146_RS21390	COG3383	formate dehydrogenase (NAD+) activity
UM146_RS21400	COG1289	transmembrane transporter activity
UM146_RS21405	COG1566	PFAM secretion protein HlyD family protein
UM146_RS21415	COG2015	COG2015, Alkyl sulfatase and related hydrolases
UM146_RS21420	COG1940	carbohydrate kinase activity
UM146_RS21425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UM146_RS21430	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS21435	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS21440	COG1129	ABC transporter
UM146_RS21445	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS21450	COG1737	Transcriptional regulator
UM146_RS21455	COG0698	ribose 5-phosphate isomerase
UM146_RS21465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UM146_RS21470	COG0456	acetyltransferase
UM146_RS21480	COG3454	Phosphonate metabolism
UM146_RS21485	COG4778	phosphonate C-P lyase system protein PhnL
UM146_RS21490	COG4107	phosphonate C-P lyase system protein PhnK
UM146_RS21495	COG3627	carbon phosphorus lyase activity
UM146_RS21500	COG3626	phosphonate metabolism
UM146_RS21505	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
UM146_RS21510	COG3624	Phosphonate C-P lyase system protein PhnG
UM146_RS21515	COG2188	Transcriptional regulator
UM146_RS21520	COG3639	organic phosphonate transmembrane transporter activity
UM146_RS21525	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
UM146_RS21535	COG2764	glyoxalase bleomycin resistance protein dioxygenase
UM146_RS21540	COG2824	Alkylphosphonate utilization operon protein PhnA
UM146_RS21555	COG0477	Major facilitator Superfamily
UM146_RS21565	COG0642	Histidine kinase
UM146_RS21570	COG0745	RESPONSE REGULATOR receiver
UM146_RS21575	COG2194	sulfuric ester hydrolase activity
UM146_RS21580	COG0531	amino acid
UM146_RS21585	COG2207	Transcriptional regulator
UM146_RS21590	COG1982	Orn Lys Arg decarboxylase major
UM146_RS21595	COG2169	Transcriptional regulator
UM146_RS21605	COG1486	melibiose metabolic process
UM146_RS21610	COG3647	Membrane
UM146_RS21615	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
UM146_RS21615	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
UM146_RS21620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
UM146_RS21630	COG4565	transcriptional regulatory protein
UM146_RS21635	COG3290	protein histidine kinase activity
UM146_RS21640	COG3592	Divergent 4Fe-4S mono-cluster
UM146_RS21645	COG2388	GCN5-related N-acetyl-transferase
UM146_RS21660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UM146_RS21665	COG3104	oligopeptide transport
UM146_RS21670	COG1982	Orn Lys Arg decarboxylase major
UM146_RS21675	COG0531	amino acid
UM146_RS21680	COG3710	Transcriptional regulator
UM146_RS21695	COG1309	transcriptional regulator
UM146_RS21710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
UM146_RS21715	COG1027	Aspartate ammonia-lyase
UM146_RS21720	COG3030	protein affecting phage T7 exclusion by the F plasmid
UM146_RS21725	COG0531	amino acid
UM146_RS21750	COG1509	lysine 2,3-aminomutase activity
UM146_RS21760	COG5510	response to toxic substance
UM146_RS21765	COG5510	response to toxic substance
UM146_RS21770	COG2076	Multidrug Resistance protein
UM146_RS21775	COG3040	lipid binding
UM146_RS21780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UM146_RS21795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UM146_RS21800	COG1053	succinate dehydrogenase
UM146_RS21810	COG0531	amino acid
UM146_RS21825	COG1511	domain protein
UM146_RS21825	COG3264	Mechanosensitive ion channel
UM146_RS21860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UM146_RS21865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UM146_RS21865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
UM146_RS21870	COG0802	atpase or kinase
UM146_RS21875	COG0860	N-Acetylmuramoyl-L-alanine amidase
UM146_RS21895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UM146_RS21900	COG0330	HflC and HflK could
UM146_RS21905	COG0330	HflC and HflK could
UM146_RS21910	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
UM146_RS21925	COG0557	exoribonuclease II activity
UM146_RS21930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UM146_RS21935	COG3789	protein conserved in bacteria
UM146_RS21940	COG1842	Phage shock protein A
UM146_RS21950	COG3766	membrane
UM146_RS21955	COG5463	Belongs to the UPF0441 family
UM146_RS21960	COG0754	glutathionylspermidine amidase activity
UM146_RS21965	COG1960	acyl-CoA dehydrogenase activity
UM146_RS21975	COG3650	response to hydrogen peroxide
UM146_RS21980	COG1073	alpha beta
UM146_RS21995	COG3037	sugar-specific permease SgaT UlaA
UM146_RS22000	COG3414	Phosphotransferase system galactitol-specific IIB component
UM146_RS22045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UM146_RS22065	COG2271	Major facilitator Superfamily
UM146_RS22075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
UM146_RS22080	COG4670	ketone body catabolic process
UM146_RS22085	COG1024	Enoyl-CoA hydratase
UM146_RS22100	COG1309	transcriptional regulator
UM146_RS22105	COG3061	Opacity-associated protein A
UM146_RS22110	COG0545	Peptidyl-prolyl cis-trans isomerase
UM146_RS22115	COG1113	amino acid transport
UM146_RS22125	COG0697	spore germination
UM146_RS22130	COG0702	epimerase
UM146_RS22135	COG1733	regulation of RNA biosynthetic process
UM146_RS22140	COG0737	Belongs to the 5'-nucleotidase family
UM146_RS22145	COG1218	3'(2'),5'-bisphosphate nucleotidase
UM146_RS22150	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
UM146_RS22160	COG1253	flavin adenine dinucleotide binding
UM146_RS22175	COG0729	surface antigen
UM146_RS22180	COG2911	Protein conserved in bacteria
UM146_RS22185	COG2105	PFAM AIG2 family protein
UM146_RS22190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
UM146_RS22195	COG1879	ABC-type sugar transport system periplasmic component
UM146_RS22200	COG1129	ABC transporter
UM146_RS22205	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS22210	COG1172	Belongs to the binding-protein-dependent transport system permease family
UM146_RS22220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UM146_RS22230	COG0312	modulator of DNA gyrase
UM146_RS22235	COG3783	Cytochrome b(562)
UM146_RS22240	COG0602	queuosine metabolic process
UM146_RS22245	COG1328	CTP reductase activity
UM146_RS22255	COG0366	Alpha amylase catalytic
UM146_RS22260	COG1263	PTS System
UM146_RS22260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UM146_RS22265	COG1609	Transcriptional regulator
UM146_RS22270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UM146_RS22275	COG0251	oxidation-reduction process
UM146_RS22295	COG1438	arginine binding
UM146_RS22300	COG1288	antiporter activity
UM146_RS22305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UM146_RS22310	COG0549	Belongs to the carbamate kinase family
UM146_RS22320	COG2731	YhcH YjgK YiaL family protein
UM146_RS22325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UM146_RS22330	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
UM146_RS22335	COG0456	acetyltransferase
UM146_RS22345	COG0525	valine-tRNA ligase activity
UM146_RS22350	COG2927	DNA polymerase III (CHI subunit)
UM146_RS22360	COG0795	lipopolysaccharide-transporting ATPase activity
UM146_RS22365	COG0795	lipopolysaccharide-transporting ATPase activity
UM146_RS22370	COG0433	COG0433 Predicted ATPase
UM146_RS22375	COG1609	Transcriptional regulator
UM146_RS22380	COG2610	gluconate transmembrane transporter activity
UM146_RS22385	COG1028	Short-chain dehydrogenase reductase Sdr
UM146_RS22390	COG1063	alcohol dehydrogenase
UM146_RS22395	COG3265	gluconokinase activity
UM146_RS22400	COG1064	alcohol dehydrogenase
UM146_RS22410	COG0582	viral genome integration into host DNA
UM146_RS22415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UM146_RS22415	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
UM146_RS22420	COG2194	sulfuric ester hydrolase activity
UM146_RS22560	COG2259	Doxx family
UM146_RS22565	COG1304	FMN binding
UM146_RS22575	COG1309	transcriptional regulator
UM146_RS22585	COG4372	Transposase
UM146_RS22590	COG3547	Transposase (IS116 IS110 IS902 family)
UM146_RS22595	COG4372	Transposase
UM146_RS22600	COG3436	PFAM IS66 Orf2 family protein
UM146_RS22610	COG2801	Transposase and inactivated derivatives
UM146_RS22620	COG2801	Transposase and inactivated derivatives
UM146_RS22665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UM146_RS22670	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
UM146_RS22675	COG0745	RESPONSE REGULATOR receiver
UM146_RS22680	COG5002	protein histidine kinase activity
UM146_RS22735	COG4372	Transposase
UM146_RS22785	COG2610	gluconate transmembrane transporter activity
UM146_RS22790	COG0583	DNA-binding transcription factor activity
UM146_RS22805	COG2076	Multidrug Resistance protein
UM146_RS22820	COG4869	propanediol catabolic process
UM146_RS22830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
UM146_RS22835	COG1882	Formate acetyltransferase
UM146_RS22840	COG1012	belongs to the aldehyde dehydrogenase family
UM146_RS22840	COG1454	alcohol dehydrogenase
UM146_RS22850	COG1012	belongs to the aldehyde dehydrogenase family
UM146_RS22850	COG1454	alcohol dehydrogenase
UM146_RS22905	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UM146_RS22910	COG1757	Na H antiporter
UM146_RS22940	COG3596	GTP binding
UM146_RS22950	COG2378	regulation of single-species biofilm formation
UM146_RS22975	COG2003	Belongs to the UPF0758 family
UM146_RS23030	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
UM146_RS23045	COG0582	viral genome integration into host DNA
UM146_RS23050	COG4974	Belongs to the 'phage' integrase family
UM146_RS23065	COG3539	Fimbrial protein
UM146_RS23070	COG3121	Chaperone
UM146_RS23075	COG3188	usher protein
UM146_RS23080	COG3539	Fimbrial protein
UM146_RS23085	COG3539	Fimbrial protein
UM146_RS23090	COG3539	Fimbrial protein
UM146_RS23105	COG0246	Mannitol dehydrogenase
UM146_RS23115	COG2186	Transcriptional regulator
UM146_RS23130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UM146_RS23130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS23135	COG1461	Dihydroxyacetone kinase
UM146_RS23140	COG2376	Dihydroxyacetone kinase
UM146_RS23155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UM146_RS23170	COG1929	Belongs to the glycerate kinase type-1 family
UM146_RS23175	COG2084	Dehydrogenase
UM146_RS23180	COG3622	Belongs to the hyi family
UM146_RS23185	COG3960	tartronate-semialdehyde synthase activity
UM146_RS23190	COG3284	Transcriptional regulator
UM146_RS23200	COG1757	Na H antiporter
UM146_RS23205	COG0583	DNA-binding transcription factor activity
UM146_RS23210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UM146_RS23215	COG0700	Nucleoside recognition
UM146_RS23220	COG3366	ferrous iron transmembrane transporter activity
UM146_RS23250	COG1924	4 iron, 4 sulfur cluster binding
UM146_RS23255	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
UM146_RS23260	COG2733	membrane
UM146_RS23280	COG0732	type I restriction modification DNA specificity domain
UM146_RS23285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
UM146_RS23290	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
UM146_RS23295	COG1715	Restriction endonuclease
UM146_RS23300	COG0523	cobalamin synthesis protein
UM146_RS23305	COG2879	small protein
UM146_RS23310	COG1966	Carbon starvation protein
UM146_RS23320	COG0840	transmembrane signaling receptor activity
UM146_RS23325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
UM146_RS23340	COG0025	NhaP-type Na H and K H
UM146_RS23345	COG1802	Transcriptional regulator
UM146_RS23350	COG1063	alcohol dehydrogenase
UM146_RS23365	COG1484	DNA-dependent DNA replication
UM146_RS23380	COG2966	Psort location CytoplasmicMembrane, score
UM146_RS23385	COG2197	response regulator
UM146_RS23390	COG2197	response regulator
UM146_RS23395	COG4114	ferric iron reductase
UM146_RS23430	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
UM146_RS23435	COG0456	acetyltransferase
UM146_RS23440	COG1011	Hydrolase
UM146_RS23450	COG2823	Periplasmic or secreted lipoprotein
UM146_RS23460	COG4667	esterase of the alpha-beta hydrolase superfamily
UM146_RS23465	COG0084	hydrolase, TatD family'
UM146_RS23470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
UM146_RS23475	COG1328	CTP reductase activity
UM146_RS23505	COG3550	peptidyl-serine autophosphorylation
UM146_RS23515	COG3726	membrane protein affecting hemolysin expression
UM146_RS23520	COG0560	Phosphoserine phosphatase
UM146_RS23525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
UM146_RS23530	COG1056	cytidyltransferase-related domain
UM146_RS23530	COG3172	ATPase kinase involved in NAD metabolism
UM146_RS23535	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
UM146_RS23545	COG0488	(ABC) transporter
UM146_RS23550	COG0741	lytic transglycosylase activity
UM146_RS23570	COG3708	Transcriptional regulator
UM146_RS23570	COG2207	Transcriptional regulator
UM146_RS23575	COG3045	CreA protein
UM146_RS23580	COG0745	RESPONSE REGULATOR receiver
UM146_RS23585	COG2205	protein histidine kinase activity
UM146_RS23590	COG4452	Inner membrane protein CreD
UM146_RS23595	COG0745	RESPONSE REGULATOR receiver
UM146_RS23605	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
UM146_RS23615	COG0460	homoserine dehydrogenase
UM146_RS23615	COG0527	aspartate kinase activity
UM146_RS23625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UM146_RS23645	COG1115	amino acid carrier protein
UM146_RS23655	COG0521	Mo-molybdopterin cofactor biosynthetic process
UM146_RS23665	COG1584	GPR1 FUN34 yaaH family protein
UM146_RS23670	COG4735	regulation of single-species biofilm formation
UM146_RS23700	COG3119	arylsulfatase activity
UM146_RS23715	COG0583	DNA-binding transcription factor activity
UM146_RS23730	COG0196	riboflavin kinase activity
UM146_RS23745	COG1047	Peptidyl-prolyl cis-trans
UM146_RS23780	COG0505	Belongs to the CarA family
UM146_RS23785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UM146_RS23850	COG0644	oxidoreductase
UM146_RS23855	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
UM146_RS23860	COG2271	Major facilitator Superfamily
UM146_RS23875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UM146_RS23905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
UM146_RS23910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UM146_RS23920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
UM146_RS23925	COG0564	pseudouridine synthase activity
UM146_RS23935	COG0417	DNA replication proofreading
UM146_RS23940	COG0235	Class ii aldolase
UM146_RS23955	COG4977	sequence-specific DNA binding
UM146_RS23970	COG0586	Pfam SNARE associated Golgi protein
UM146_RS23980	COG1178	ABC-type Fe3 transport system permease component
UM146_RS23985	COG4143	(ABC) transporter
UM146_RS24025	COG0583	DNA-binding transcription factor activity
UM146_RS24030	COG0028	Belongs to the TPP enzyme family
UM146_RS24035	COG0440	acetolactate synthase activity
UM146_RS24045	COG1609	Transcriptional regulator
UM146_RS24060	COG3116	cell division
UM146_RS24065	COG0768	penicillin binding
UM146_RS24070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UM146_RS24075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UM146_RS24090	COG0772	Belongs to the SEDS family
UM146_RS24105	COG1181	Belongs to the D-alanine--D-alanine ligase family
UM146_RS24110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
UM146_RS24115	COG0849	cell division
UM146_RS24120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UM146_RS24140	COG0494	nUDIX hydrolase
UM146_RS24155	COG0237	dephospho-CoA kinase activity
UM146_RS24165	COG1459	type II secretion system
UM146_RS24170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UM146_RS24175	COG4969	Belongs to the N-Me-Phe pilin family
UM146_RS24185	COG0157	Belongs to the NadC ModD family
UM146_RS24190	COG3023	N-Acetylmuramoyl-L-alanine amidase
UM146_RS24195	COG3725	Membrane protein required for beta-lactamase induction
UM146_RS24200	COG1113	amino acid transport
UM146_RS24205	COG3157	Type VI secretion system effector, Hcp
UM146_RS24235	COG2186	Transcriptional regulator
UM146_RS24240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
UM146_RS24245	COG0508	dehydrogenase complex catalyzes the overall conversion of
UM146_RS24250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UM146_RS24255	COG3064	Membrane
UM146_RS24260	COG1049	propionate catabolic process, 2-methylcitrate cycle
UM146_RS24285	COG2132	Multicopper oxidase
UM146_RS24290	COG4993	Dehydrogenase
UM146_RS24295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
UM146_RS24300	COG0288	reversible hydration of carbon dioxide
UM146_RS24305	COG1131	(ABC) transporter
UM146_RS24310	COG0842	Transport permease protein
UM146_RS24315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
UM146_RS24320	COG0726	polysaccharide deacetylase
UM146_RS24330	COG5464	transposase or invertase
UM146_RS24350	COG3539	Fimbrial protein
UM146_RS24355	COG3539	Fimbrial protein
UM146_RS24360	COG3539	Fimbrial protein
UM146_RS24365	COG3188	usher protein
UM146_RS24370	COG3121	Chaperone
UM146_RS24375	COG3539	Fimbrial protein
UM146_RS24380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UM146_RS24385	COG0617	tRNA 3'-terminal CCA addition
UM146_RS24390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UM146_RS24395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UM146_RS24405	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
UM146_RS24410	COG1643	Atp-dependent helicase
UM146_RS24415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UM146_RS24420	COG4774	siderophore transport
UM146_RS24425	COG1120	ATPase activity
UM146_RS24430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UM146_RS24435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UM146_RS24455	COG2860	membrane
UM146_RS24460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UM146_RS24475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UM146_RS24480	COG3835	regulator
UM146_RS24500	COG0024	Methionine aminopeptidase
UM146_RS24525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UM146_RS24530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UM146_RS24535	COG0575	Belongs to the CDS family
UM146_RS24540	COG0750	zinc metalloprotease
UM146_RS24550	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
UM146_RS24580	COG0587	DNA-directed DNA polymerase activity
UM146_RS24590	COG1982	Orn Lys Arg decarboxylase major
UM146_RS24595	COG0346	lactoylglutathione lyase activity
UM146_RS24600	COG0037	tRNA processing
UM146_RS24605	COG4568	rho-dependent transcription termination
UM146_RS24615	COG4681	YaeQ
UM146_RS24620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UM146_RS24625	COG3015	lipoprotein NlpE involved in copper resistance
UM146_RS24630	COG0791	NLP P60 protein
UM146_RS24640	COG1720	tRNA m6t6A37 methyltransferase activity
UM146_RS24650	COG1464	Belongs to the NlpA lipoprotein family
UM146_RS24655	COG2011	ABC-type metal ion transport system permease component
UM146_RS24660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UM146_RS24665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UM146_RS24735	COG0765	amino acid transport
UM146_RS25155	COG2198	Histidine kinase
UM146_RS25155	COG0784	Response regulator, receiver
UM146_RS25155	COG5002	protein histidine kinase activity
UM146_RS25430	COG2963	transposase activity
UM146_RS25435	COG0840	transmembrane signaling receptor activity