locus-tag class description G4273_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G4273_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4273_RS00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) G4273_RS00030 ENOG410667J hydrolase G4273_RS00035 ENOG410657R replicase EC 2.7 G4273_RS00040 ENOG4105EMF GntR family transcriptional regulator G4273_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 G4273_RS00050 ENOG4108RTU Aldolase G4273_RS00060 ENOG4105DJB Major Facilitator Superfamily G4273_RS00065 ENOG4107WAP fad NAD(P)-binding domain G4273_RS00070 ENOG4105D99 atp gtp-binding protein G4273_RS00075 ENOG4105R2A (LipO)protein G4273_RS00095 ENOG4108AHD Transcriptional regulator G4273_RS00100 ENOG4107RUZ Sss sodium solute transporter superfamily G4273_RS00105 ENOG4105CBG Sulfatase G4273_RS00110 ENOG4105VG5 Membrane G4273_RS00115 ENOG4105JP4 Inner membrane protein yidG G4273_RS00120 ENOG4105J13 transcriptional regulator G4273_RS00125 ENOG4105E5M Multidrug resistance protein D G4273_RS00135 ENOG4105C7K acetolactate synthase G4273_RS00140 ENOG4105M71 acetolactate synthase 1 regulatory subunit G4273_RS00145 ENOG4108KX4 response regulator G4273_RS00150 ENOG4105BZU Histidine kinase G4273_RS00155 ENOG4105CXY transporter G4273_RS00160 ENOG4105CXY transporter G4273_RS00170 ENOG4105C7N Xanthine uracil vitamin C permease G4273_RS00175 ENOG4108SAJ Protein of unknown function (DUF1198) G4273_RS00195 ENOG4105T8A Uncharacterized protein YicS G4273_RS00200 ENOG4105D01 (LipO)protein G4273_RS00205 ENOG4108UZ3 Transporter G4273_RS00225 ENOG4105CT4 transporter G4273_RS00230 ENOG4105CJQ hydrolase, family 31 G4273_RS00235 ENOG4105ETD TRANSCRIPTIONal G4273_RS00240 ENOG4105DM4 PTS System G4273_RS00245 ENOG4108YRF PTS System G4273_RS00250 ENOG4105DM4 PTS System G4273_RS00255 ENOG4105D2N Aldolase G4273_RS00260 ENOG4105D2N Aldolase G4273_RS00265 ENOG4105DKQ ROK family G4273_RS00275 ENOG4105JV1 AsmA family G4273_RS00280 ENOG4105C2W permease G4273_RS00285 ENOG4105D6U Sodium Glutamate Symporter G4273_RS00290 ENOG4105CB5 ATP-dependent DNA helicase recG G4273_RS00295 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase G4273_RS00300 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G4273_RS00310 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G4273_RS00320 ENOG4105EN6 Membrane G4273_RS00325 ENOG4105F5P DNA-damage-inducible protein d G4273_RS00330 ENOG4105DSJ YicC domain protein G4273_RS00355 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G4273_RS00365 ENOG4105KDC 50s ribosomal protein l28 G4273_RS00385 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G4273_RS00390 ENOG4105DKP glycosyl transferase, family 9 G4273_RS00395 ENOG4107RJ7 Glycosyl transferase (Group 1 G4273_RS00400 ENOG4107543 (lipo)polysaccharide G4273_RS00405 ENOG4106AH0 Glycosyl Transferase G4273_RS00410 ENOG4105X1N Glycosyl transferase family 8 G4273_RS00420 ENOG4105X1N Glycosyl transferase family 8 G4273_RS00425 ENOG4105K64 Glycosyl transferase, family 2 G4273_RS00430 ENOG41068PG O-Antigen polymerase G4273_RS00435 ENOG4105D16 lipopolysaccharide heptosyltransferase i G4273_RS00440 ENOG4105XA0 heptosyltransferase ii G4273_RS00450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4273_RS00460 ENOG4105K64 Glycosyl transferase, family 2 G4273_RS00465 ENOG4105PXI polysaccharide deacetylase G4273_RS00470 ENOG41063SB peptidase G4273_RS00480 ENOG4107YZP Rhodanese domain protein G4273_RS00485 ENOG4105VW4 glutaredoxin 3 G4273_RS00500 ENOG4105D7W serine acetyltransferase G4273_RS00505 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G4273_RS00515 ENOG41073TP transcriptional regulator G4273_RS00520 ENOG4105DAA L-lactate G4273_RS00530 ENOG4108WY4 inner membrane lipoprotein G4273_RS00535 ENOG4108YYI Protein of unknown function (DUF2810) G4273_RS00540 ENOG41060ND LF82 chromosome, complete sequence G4273_RS00545 ENOG4105E61 Mannitol repressor protein G4273_RS00555 ENOG4105CTS PTS system mannitol-specific G4273_RS00560 ENOG4105FP6 Protein of unknown function (DUF3302) G4273_RS00565 ENOG4105EFX secretion protein, HlyD family G4273_RS00570 ENOG4108U78 Glutathione S-transferase G4273_RS00580 ENOG4105EM7 Selenocysteine-specific translation elongation factor G4273_RS00585 ENOG4105C0A alcohol dehydrogenase G4273_RS00595 ENOG4105C26 Dehydrogenase G4273_RS00600 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G4273_RS00605 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase G4273_RS00610 ENOG4105H6Q decarboxylase G4273_RS00615 ENOG4105CMG Carbohydrate kinase G4273_RS00620 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G4273_RS00625 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G4273_RS00630 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter G4273_RS00635 ENOG4108M5W G4273_RS00640 ENOG4108R66 Conserved Protein G4273_RS00650 ENOG4105J4Q Transcriptional regulator G4273_RS00655 ENOG4108XIB electron transport protein ysaA G4273_RS00660 ENOG4105JKW Valine--pyruvate aminotransferase G4273_RS00665 ENOG4107T9C Alpha amylase catalytic region G4273_RS00670 ENOG4108UR8 BAX protein G4273_RS00675 ENOG4105T16 Transcriptional regulator (AraC family) G4273_RS00680 ENOG4108HWW ABC transporter G4273_RS00685 ENOG4105C2J ABC transporter G4273_RS00690 ENOG4105DFW ABC transporter G4273_RS00700 ENOG4105CMG Carbohydrate kinase G4273_RS00705 ENOG410688U Inner membrane protein yiaB G4273_RS00710 ENOG4108Z12 YiaAB two helix domain-containing protein G4273_RS00715 ENOG4105MEV Acyl-transferase G4273_RS00735 ENOG41060TC Hok gef cell toxic protein G4273_RS00745 ENOG4105MVF Transcriptional regulator G4273_RS00750 ENOG4106JH6 (LipO)protein G4273_RS00760 ENOG4108ZG0 Ompa motb domain protein G4273_RS00765 ENOG4107QY8 reductase G4273_RS00770 ENOG4105HNP -acetyltransferase G4273_RS00775 ENOG4108R3E Dna-3-methyladenine glycosylase i G4273_RS00780 ENOG4105EAX Putative lipase G4273_RS00785 ENOG4105FCD Major Facilitator G4273_RS00790 ENOG4105DIJ Phosphoethanolamine transferase G4273_RS00800 ENOG4105DEF Extracellular solute-binding protein, family 5 G4273_RS00805 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4273_RS00810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4273_RS00815 ENOG4105C3U ABC transporter G4273_RS00820 ENOG4108JQ7 (ABC) transporter G4273_RS00825 ENOG4105C44 Serine transporter G4273_RS00840 ENOG4105D1V cellulose synthase operon protein YhjU G4273_RS00845 ENOG4105WQA Cellulose biosynthesis protein BcsF G4273_RS00850 ENOG4105U74 cellulose biosynthesis protein BcsE G4273_RS00855 ENOG410661M cytoplasmic protein G4273_RS00865 ENOG4107QZ7 Cellulose synthase catalytic subunit G4273_RS00870 ENOG4107EEX Cellulose synthase regulator protein G4273_RS00875 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) G4273_RS00880 ENOG4105EJG cellulose synthase G4273_RS00885 ENOG4105BZU Histidine kinase G4273_RS00895 ENOG4105CS0 peptidase G4273_RS00900 ENOG4107SS6 2-dehydro-3-deoxygluconokinase G4273_RS00905 ENOG4105CMB EAL domain-containing protein G4273_RS00910 ENOG41066T0 asmA family G4273_RS00915 ENOG4105CSH Transporter G4273_RS00920 ENOG4107H3J ribonuclease G4273_RS00925 ENOG4105CBN LysR family transcriptional regulator G4273_RS00930 ENOG4106S2D Transcriptional regulator G4273_RS00940 ENOG4105CA0 peroxidase G4273_RS00945 ENOG4105CVK Glutamate decarboxylase G4273_RS00955 ENOG4105D3F AraC Family Transcriptional Regulator G4273_RS00960 ENOG4105BZS acriflavin resistance protein G4273_RS00965 ENOG4105C1P efflux transporter, rnd family, mfp subunit G4273_RS00975 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci G4273_RS00980 ENOG4108YK4 Acid-resistance membrane protein G4273_RS00985 ENOG41060V2 Acid-resistance protein G4273_RS00990 ENOG4105XXV Acid-resistance protein G4273_RS00995 ENOG4105KT7 mgtC SapB transporter G4273_RS01000 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G4273_RS01005 ENOG4105EHG Permease protein G4273_RS01015 ENOG41090JE Utilization Protein G4273_RS01020 ENOG4105D4P Coproporphyrinogen iii oxidase G4273_RS01030 ENOG4107ENK receptor G4273_RS01035 ENOG4106QJH hemin transport protein G4273_RS01045 ENOG4105Y4Z Outer Membrane Lipoprotein G4273_RS01055 ENOG4105K89 arsenate reductase G4273_RS01065 ENOG4105DC8 reductase G4273_RS01070 ENOG4105D6S protein involved in catabolism of external DNA G4273_RS01075 ENOG4105DGW oligopeptidase A G4273_RS01085 ENOG4105DUX Transporter G4273_RS01100 ENOG4105CJ3 phosphate transporter G4273_RS01105 ENOG4105CBX hi0933 family G4273_RS01110 ENOG4107UNS conserved inner membrane protein G4273_RS01115 ENOG4105D0S secretion protein (HlyD G4273_RS01120 ENOG4105CJ1 ABC, transporter G4273_RS01125 ENOG4105CMI transporter G4273_RS01130 ENOG4105D2N Aldolase G4273_RS01145 ENOG4105DT3 PTS system, galactitol-specific IIc component G4273_RS01150 ENOG41090UW PTS System G4273_RS01170 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) G4273_RS01175 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) G4273_RS01180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4273_RS01185 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4273_RS01190 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein G4273_RS01195 ENOG4107YAK holo-(acyl carrier protein) synthase 2 G4273_RS01200 ENOG4105DSF transport protein G4273_RS01205 ENOG4105F9N Major Facilitator Superfamily G4273_RS01210 ENOG4108W1V Lipoprotein G4273_RS01215 ENOG4105EX9 Membrane G4273_RS01230 ENOG4107FS9 Membrane G4273_RS01240 ENOG4105MG3 Membrane G4273_RS01245 ENOG4106H78 methyltransferase G4273_RS01250 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G4273_RS01255 ENOG4105CAK Cell division ATP-binding protein ftsE G4273_RS01260 ENOG4105CRP Part of the ABC transporter FtsEX involved in G4273_RS01265 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4273_RS01270 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G4273_RS01275 ENOG4108JQ1 Dehydrogenase G4273_RS01300 ENOG4105CP9 extracellular ligand-binding receptor G4273_RS01305 ENOG4105U59 -acetyltransferase G4273_RS01310 ENOG4105CP9 extracellular ligand-binding receptor G4273_RS01315 ENOG4105C32 Amino acid ABC transporter (Permease) G4273_RS01320 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G4273_RS01325 ENOG4105C0Z ABC transporter G4273_RS01330 ENOG4108IV0 ABC, transporter G4273_RS01335 ENOG4105BZ7 extracellular solute-binding protein family 1 G4273_RS01355 ENOG4107T6V glycerophosphoryl diester phosphodiesterase G4273_RS01360 ENOG4105WC8 Conserved Protein G4273_RS01365 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G4273_RS01370 ENOG4106FA4 G4273_RS01385 ENOG4105GMB type VI secretion system effector, hcp1 family G4273_RS01390 ENOG4105WCN acetyltransferase G4273_RS01395 ENOG4105D9R oxidoreductase G4273_RS01400 ENOG4105C2I pirin domain protein G4273_RS01405 ENOG4105DIQ Transcriptional regulator G4273_RS01410 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G4273_RS01415 ENOG4105C6Z Gluconate G4273_RS01420 ENOG41076UM multiple antibiotic resistance (MarC)-related protein G4273_RS01425 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G4273_RS01450 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G4273_RS01460 ENOG4108NAE Fimbrial chaperone protein G4273_RS01465 ENOG4105CW0 outer membrane usher protein G4273_RS01475 ENOG4108RQP Major type 1 subunit fimbrin G4273_RS01480 ENOG4108AF8 Chaperone G4273_RS01485 ENOG4105MHR Fimbrial protein G4273_RS01505 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G4273_RS01520 ENOG4105E98 transcriptional regulator DeoR family G4273_RS01525 ENOG4105CYB regulatoR G4273_RS01530 ENOG4105E0Y RtcB Protein G4273_RS01540 ENOG41061ZR Transcriptional regulator G4273_RS01545 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G4273_RS01550 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) G4273_RS01555 ENOG4105C6Z Gluconate G4273_RS01565 ENOG4105MJ2 Competence protein G4273_RS01570 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G4273_RS01585 ENOG4105CE1 Ferrous iron transport protein b G4273_RS01590 ENOG4105XFK Ferrous iron transport protein A G4273_RS01595 ENOG4105BZM domain protein G4273_RS01600 ENOG4108RRZ Transcription elongation factor GreB G4273_RS01610 ENOG4105E0F Histidine kinase G4273_RS01620 ENOG4108MAJ Membrane G4273_RS01630 ENOG4105VEJ Heat shock protein G4273_RS01635 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 G4273_RS01640 ENOG4105DQY intracellular growth attenuator G4273_RS01645 ENOG4107RK2 ADP-ribose diphosphatase NudE G4273_RS01650 ENOG4108JQC penicillin-binding protein 1A G4273_RS01655 ENOG4108U1Q Pilus assembly protein G4273_RS01660 ENOG41065NF Fimbrial assembly family protein G4273_RS01665 ENOG4105XPX DNA utilization protein HofO G4273_RS01670 ENOG4105ITY Required for the use of extracellular DNA as a nutrient G4273_RS01675 ENOG4105E4G Type IV pilus G4273_RS01690 ENOG4105EGB membrane protein DamX G4273_RS01695 ENOG4105DFE Dna adenine methylase G4273_RS01700 ENOG4105DJV ribulose-phosphate 3-epimerase G4273_RS01705 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G4273_RS01710 ENOG4105C31 Tryptophanyl-tRNA synthetase G4273_RS01715 ENOG4108M21 G4273_RS01720 ENOG4105RMW regulation of transcription, DNA-dependent G4273_RS01725 ENOG4108626 Racemase G4273_RS01730 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) G4273_RS01735 ENOG41080QX K07048 phosphotriesterase-related protein G4273_RS01740 ENOG4105MUZ Protein of unknown function DUF2620 G4273_RS01745 ENOG4106M0N transport system permease protein G4273_RS01750 ENOG4106PKC pyridoxal phosphate binding G4273_RS01755 ENOG4105VYH G4273_RS01765 ENOG4107V9H nitrite transporter G4273_RS01770 ENOG4105WZK nitrite reductase NADPH small subunit G4273_RS01775 ENOG4107QZF nitrite reductase NADPH large subunit G4273_RS01785 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G4273_RS01795 ENOG4105MZU cell filamentation protein G4273_RS01800 ENOG4105DDQ anthranilate synthase G4273_RS01805 ENOG4105C8Y Acetylornithine aminotransferase G4273_RS01810 ENOG410613R integral membrane protein, YccS YhfK family G4273_RS01820 ENOG4108UKZ OsmC family G4273_RS01825 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) G4273_RS01835 ENOG4105DNZ Alpha Beta Hydrolase G4273_RS01840 ENOG4105C5H ABC transporter G4273_RS01855 ENOG4105VKU nucleicacid-binding protein G4273_RS01860 ENOG4108YZY peptidylprolyl cis-trans isomerase G4273_RS01870 ENOG4108V1T peptidylprolyl cis-trans isomerase G4273_RS01875 ENOG4105WWK YheO domain protein G4273_RS01915 ENOG4108NNZ chitinase G4273_RS01920 ENOG4105W53 bacterioferritin-associated ferredoxin G4273_RS01925 ENOG4108UQY Iron-storage protein G4273_RS01930 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) G4273_RS01940 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) G4273_RS01945 ENOG4105R04 type II secretion system protein K G4273_RS01960 ENOG41069X0 general secretion pathway protein h G4273_RS01965 ENOG4108VAU general secretion pathway protein G G4273_RS01970 ENOG4105D7Q type ii secretion system G4273_RS01975 ENOG4107QHF type ii secretion system protein e G4273_RS01980 ENOG4105GVR general secretion pathway protein D G4273_RS01985 ENOG4107KSE General secretion pathway protein C G4273_RS01990 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression G4273_RS01995 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication G4273_RS02015 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G4273_RS02105 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G4273_RS02110 ENOG41067V7 50S ribosomal protein L36 G4273_RS02140 ENOG4105VTS DnaJ-like, subfamily C G4273_RS02145 ENOG4105W1Y Transcriptional regulator G4273_RS02150 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system G4273_RS02160 ENOG4105C1A potassium transporter peripheral membrane G4273_RS02165 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G4273_RS02170 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G4273_RS02180 ENOG4105C79 DNA protecting protein DprA G4273_RS02190 ENOG4108WI1 Dna topoisomerase G4273_RS02195 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G4273_RS02200 ENOG4105E2X shikimate dehydrogenase G4273_RS02205 ENOG4105SG3 Protein of unknown function (DUF1488) G4273_RS02210 ENOG4108Z0R Transferase G4273_RS02250 ENOG4105CDA abc transporter atp-binding protein G4273_RS02255 ENOG4105DRP amino acid AbC transporter G4273_RS02260 ENOG4105EZ7 amino acid ABC transporter G4273_RS02270 ENOG4105XCM membrane LIPOPROTEIN G4273_RS02275 ENOG4105BZS acriflavin resistance protein G4273_RS02280 ENOG4105C1P efflux transporter, rnd family, mfp subunit G4273_RS02285 ENOG4108XG4 DNA-binding transcriptional regulator G4273_RS02290 ENOG41061ME transport protein G4273_RS02295 ENOG4105CEC DNA methylase N-4 N-6 G4273_RS02305 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G4273_RS02315 ENOG4108IA2 Sodium pantothenate symporter G4273_RS02320 ENOG4105RG0 Membrane G4273_RS02325 ENOG4107UEK pfkb domain protein G4273_RS02330 ENOG4105E98 transcriptional regulator DeoR family G4273_RS02335 ENOG4105D2N Aldolase G4273_RS02340 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G4273_RS02345 ENOG4105C2J ABC transporter G4273_RS02350 ENOG4105CNN ABC, transporter G4273_RS02355 ENOG4107UEK pfkb domain protein G4273_RS02365 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G4273_RS02370 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G4273_RS02380 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G4273_RS02385 ENOG41062P1 Diguanylate cyclase phosphodiesterase G4273_RS02395 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) G4273_RS02400 ENOG4105VQ7 Rod shape-determining protein MreD G4273_RS02405 ENOG4108Z03 MAF-like protein G4273_RS02410 ENOG4105C03 ribonuclease G4273_RS02415 ENOG4105QD6 exported protein G4273_RS02420 ENOG4105D1U peptidase U62 modulator of DNA gyrase G4273_RS02425 ENOG4105CR8 Transcriptional regulator G4273_RS02430 ENOG4105ZQC membrane protein AaeX G4273_RS02440 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) G4273_RS02445 ENOG4105UNR (Barnase) inhibitor G4273_RS02450 ENOG4105RID UPF0379 protein yhcN G4273_RS02465 ENOG4105C0H protease G4273_RS02470 ENOG4105C0H protease G4273_RS02475 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III G4273_RS02480 ENOG4105D6Z AFG1 family ATPase G4273_RS02495 ENOG4107MKT Stringent starvation protein a G4273_RS02500 ENOG4105KB2 stringent starvation protein b G4273_RS02515 ENOG4105JHE Major Facilitator Superfamily G4273_RS02530 ENOG4108R66 Conserved Protein G4273_RS02535 ENOG4105DFS Conserved Protein G4273_RS02540 ENOG4105BZ8 glutamate synthase G4273_RS02545 ENOG4105CBC glutamate synthase G4273_RS02550 ENOG4105N5T Radical SAM Protein G4273_RS02555 ENOG4105BZU Histidine kinase G4273_RS02560 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain G4273_RS02575 ENOG41080Z8 PHOSPHOCARRIER protein G4273_RS02585 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN G4273_RS02590 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA G4273_RS02595 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4273_RS02600 ENOG4108IUZ ABC transporter G4273_RS02605 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G4273_RS02610 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) G4273_RS02620 ENOG4105C2X Arabinose 5-phosphate isomerase G4273_RS02625 ENOG4105FEU K -dependent Na -Ca exchanger G4273_RS02630 ENOG4105DHJ ABC, transporter G4273_RS02635 ENOG4105CY3 ABC transporter, permease G4273_RS02640 ENOG4107PE3 Mammalian cell entry related domain protein G4273_RS02645 ENOG4105E3I toluene tolerance G4273_RS02650 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane G4273_RS02655 ENOG4105VFK BolA family G4273_RS02665 ENOG4105HVQ Regulatory factor of maltose metabolism G4273_RS02670 ENOG4105EAH synthase G4273_RS02685 ENOG4105QYV Membrane G4273_RS02695 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase G4273_RS02700 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G4273_RS02705 ENOG4105HBR Rna-binding protein G4273_RS02715 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G4273_RS02720 ENOG4105EEI dihydropteroate synthase G4273_RS02730 ENOG4105NTZ Preprotein translocase subunit SecG G4273_RS02740 ENOG4105DIJ Phosphoethanolamine transferase G4273_RS02760 ENOG4105CHV Transcription elongation factor NusA G4273_RS02800 ENOG4105C1J atp-dependent rna helicase G4273_RS02805 ENOG4105CIC tryptophan-specific transport protein G4273_RS02810 ENOG4105DEN Luciferase family G4273_RS02830 ENOG4108YYD acetyltransferase G4273_RS02845 ENOG4107R7Y intracellular protease Pfpi family G4273_RS02850 ENOG4105K4T epimerase G4273_RS02855 ENOG4107S21 permease G4273_RS02860 ENOG4105W4M Transport-associated protein G4273_RS02880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G4273_RS02885 ENOG4106HBN Galactosamine-6-phosphate isomerase G4273_RS02890 ENOG4105F3R pts system mannose fructose sorbose family iid G4273_RS02895 ENOG4105ETZ PTS System G4273_RS02900 ENOG4108UZY PTS System G4273_RS02910 ENOG4105E70 isomerase G4273_RS02915 ENOG4105CE4 GlcNAc 6-P deacetylase G4273_RS02920 ENOG4108YTN IIa component G4273_RS02925 ENOG4105F3R pts system mannose fructose sorbose family iid G4273_RS02935 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB G4273_RS02945 ENOG4105E98 transcriptional regulator DeoR family G4273_RS02950 ENOG4105CTX dehydratase G4273_RS02955 ENOG4105DJB Major Facilitator Superfamily G4273_RS02965 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G4273_RS02970 ENOG4105BZW Glycerate kinase G4273_RS02985 ENOG410811B TRANSCRIPTIONal G4273_RS02990 ENOG4105C7B Threonine dehydratase G4273_RS03005 ENOG4105C6N Formate acetyltransferase G4273_RS03010 ENOG4105KME endoribonuclease L-psp G4273_RS03015 ENOG4105EJQ L-serine dehydratase G4273_RS03020 ENOG4105C44 Serine transporter G4273_RS03030 ENOG4106D80 Uncharacterized protein YhaL G4273_RS03035 ENOG4108CNN domain protein G4273_RS03040 ENOG4105CWB LysR family transcriptional Regulator G4273_RS03045 ENOG4105KAF membrAne G4273_RS03050 ENOG4105CHF Glutathione S-transferase G4273_RS03055 ENOG4108VBZ doxx family G4273_RS03060 ENOG4105YJD G4273_RS03065 ENOG41090KG Inner membrane protein YqjE G4273_RS03070 ENOG4105NE1 Conserved Protein G4273_RS03075 ENOG4105WAY exported protein G4273_RS03080 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) G4273_RS03085 ENOG4106W5V Membrane G4273_RS03090 ENOG4107YCY Transcriptional regulator G4273_RS03095 ENOG4105DPW Major facilitator superfamily MFS_1 G4273_RS03105 ENOG4105CTX dehydratase G4273_RS03110 ENOG4105P66 Membrane G4273_RS03120 ENOG4105DU1 integral membrane protein, terc G4273_RS03125 ENOG4105EE0 oxidoreductase G4273_RS03130 ENOG4108UB4 uncharacterized protein ygjQ G4273_RS03135 ENOG4108VKG metal-dependent hydrolase G4273_RS03150 ENOG4108Z3N Transcriptional regulator G4273_RS03155 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4273_RS03160 ENOG4107WCA isomerase G4273_RS03165 ENOG4107W6W Conserved Protein G4273_RS03170 ENOG4105E5D amino acid G4273_RS03175 ENOG4105FK9 beta-D-galactosidase beta subunit G4273_RS03180 ENOG4105CNT hydrolase family 2 G4273_RS03185 ENOG4105CQ4 Transcriptional regulator G4273_RS03190 ENOG4108Y51 tRNA-binding protein G4273_RS03200 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor G4273_RS03205 ENOG4105NTW Transcriptional regulator G4273_RS03210 ENOG4105Q26 Siderophore-interacting protein G4273_RS03225 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4273_RS03230 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G4273_RS03240 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G4273_RS03245 ENOG4107QPK )-transporter G4273_RS03250 ENOG4107GFK fumarate G4273_RS03270 ENOG4107ZVW dihydroneopterin aldolase G4273_RS03280 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G4273_RS03285 ENOG4106MWK domain protein G4273_RS03290 ENOG4105D7V transposase G4273_RS03300 ENOG4105I7R Adenylate cyclase G4273_RS03305 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G4273_RS03320 ENOG4107S78 Band 7 protein G4273_RS03325 ENOG4105PV3 Inner membrane protein yqiJ G4273_RS03335 ENOG4105W0Z cytoplasmic protein G4273_RS03345 ENOG4108MY7 Fimbrial G4273_RS03350 ENOG4108TTM chaperone G4273_RS03360 ENOG4105H8W Fimbrial protein G4273_RS03375 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G4273_RS03385 ENOG4108N92 Thiol disulfide Interchange Protein G4273_RS03390 ENOG4108MR7 Arylsulfotransferase G4273_RS03395 ENOG4106032 Glutathionylspermidine synthase G4273_RS03405 ENOG4105DFG type I secretion outer membrane protein G4273_RS03410 ENOG41087AY ADP-Ribose pyrophosphatase G4273_RS03415 ENOG4108SX3 cytoplasmic protein G4273_RS03420 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G4273_RS03425 ENOG4105IPS esterase G4273_RS03430 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4273_RS03440 ENOG4105E0A ABC, transporter G4273_RS03445 ENOG4105DQ5 transport system permease protein G4273_RS03450 ENOG4105EHG Permease protein G4273_RS03460 ENOG4106KNT transcriptional regulator G4273_RS03465 ENOG4105VRH Antibiotic biosynthesis monooxygenase G4273_RS03470 ENOG4105NF4 modulator of drug activity G4273_RS03480 ENOG4107DEU Inner membrane protein YgiZ G4273_RS03485 ENOG4105DHQ Histidine kinase G4273_RS03490 ENOG4105XJC Two component transcriptional regulator (Winged helix family G4273_RS03495 ENOG4105H4F exported protein G4273_RS03500 ENOG4105F4I Transcriptional regulator G4273_RS03505 ENOG4108J59 Extracellular solute-binding protein, family 5 G4273_RS03510 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4273_RS03515 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase G4273_RS03520 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) G4273_RS03525 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G4273_RS03535 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G4273_RS03540 ENOG4105DG4 malate L-lactate dehydrogenase G4273_RS03545 ENOG4105CPQ Dehydrogenase G4273_RS03550 ENOG4105DEI Mannitol dehydrogenase G4273_RS03555 ENOG4107YCY Transcriptional regulator G4273_RS03570 ENOG4105ZKC Conserved Protein G4273_RS03575 ENOG4105CV8 reductase G4273_RS03580 ENOG4108I6A alcohol dehydrogenase G4273_RS03585 ENOG4105CF7 AraC family transcriptional regulator G4273_RS03590 ENOG4108K81 inner membrane protein YghB G4273_RS03595 ENOG4105C28 cystathionine G4273_RS03600 ENOG4105CWK Biopolymer transport protein, ExbB G4273_RS03605 ENOG4108ZZF transport protein (ExbD) G4273_RS03610 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G4273_RS03620 ENOG4105CPC Aldo Keto reductase G4273_RS03630 ENOG410900S Protein of unknown function (DUF2623) G4273_RS03635 ENOG4105E3S small subunit G4273_RS03640 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G4273_RS03645 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit G4273_RS03650 ENOG4105DPX Hydrogenase, large subunit G4273_RS03655 ENOG4108USZ hydrogenase G4273_RS03660 ENOG4108WGS hydrogenase 2-specific chaperone G4273_RS03665 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G4273_RS03670 ENOG41082MF Hydrogenase assembly chaperone hypC hupF G4273_RS03675 ENOG4105CYM Glutathione S-transferase G4273_RS03680 ENOG4106032 Glutathionylspermidine synthase G4273_RS03685 ENOG4105CJ3 phosphate transporter G4273_RS03690 ENOG4108GH0 ATP-binding protein yghT G4273_RS03695 ENOG4108NDC ATP-binding protein yghS G4273_RS03700 ENOG4106FPV ATP-binding protein YghR G4273_RS03705 ENOG4108S55 polysaccharide biosynthesis protein G4273_RS03715 ENOG4108UUE Transcriptional regulator G4273_RS03720 ENOG4108M8S permease YjgP YjgQ family protein G4273_RS03730 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4273_RS03735 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G4273_RS03745 ENOG4107RCI amp-dependent synthetase and ligase G4273_RS03755 ENOG4108KWP DNA-binding transcriptional regulator GlcC G4273_RS03760 ENOG4105CQB FAD linked oxidase domain protein G4273_RS03765 ENOG4105EU8 FAD linked oxidase domain protein G4273_RS03770 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4273_RS03775 ENOG4108ZJF Glcg protein G4273_RS03780 ENOG4107QP3 malate synthase g G4273_RS03785 ENOG4105DAA L-lactate G4273_RS03790 ENOG4105F88 accessory colonization factor AcfD G4273_RS03795 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) G4273_RS03800 ENOG410765S (LipO)protein G4273_RS03815 ENOG4107QHF type ii secretion system protein e G4273_RS03820 ENOG4105D7Q type ii secretion system G4273_RS03825 ENOG4108VAU general secretion pathway protein G G4273_RS03835 ENOG4105X5Z General secretion pathway protein I G4273_RS03855 ENOG4105U1E general secretion pathway protein M G4273_RS03860 ENOG41090SZ ABC-2 type transporter G4273_RS03910 ENOG41084CK capsule polysaccharide G4273_RS03915 ENOG4105E12 capsule polysaccharide G4273_RS03920 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) G4273_RS03925 ENOG4107V1M polysaccharide export protein G4273_RS03930 ENOG4105ECX polysaccharide export G4273_RS03935 ENOG4105C2X Arabinose 5-phosphate isomerase G4273_RS03985 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4273_RS04000 ENOG4108YGG dna repair protein G4273_RS04005 ENOG4105MFG Antirestriction protein G4273_RS04010 ENOG4106H6R UPF0380 protein G4273_RS04025 ENOG4108PZQ Inner membrane protein YeeR G4273_RS04045 ENOG4105F4K antigen 43 G4273_RS04055 ENOG4108P8R G4273_RS04090 ENOG4105E5H Transposase G4273_RS04100 ENOG4108YXQ IS66 Orf2 family protein G4273_RS04115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G4273_RS04120 ENOG4108REK sugar kinase G4273_RS04125 ENOG4107RGD Major Facilitator superfamily G4273_RS04135 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria G4273_RS04140 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) G4273_RS04175 ENOG4105DUU IucA IucC family protein G4273_RS04180 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) G4273_RS04205 ENOG4105D05 Receptor G4273_RS04255 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 G4273_RS04280 ENOG4108ZJG MrfB protein G4273_RS04285 ENOG4106PG1 outer membrane usher protein G4273_RS04290 ENOG4106P2F Pfam:Pili_assembly_C G4273_RS04300 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR G4273_RS04320 ENOG41067TZ transcriptional regulator, MarR family G4273_RS04340 ENOG4108YXQ IS66 Orf2 family protein G4273_RS04355 ENOG4105C42 Type I secretion membrane fusion protein (HlyD G4273_RS04360 ENOG4108JJA ABC, transporter G4273_RS04365 ENOG4107V48 Hemolysin-type calcium-binding G4273_RS04370 ENOG4108RC6 RTX toxin G4273_RS04380 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G4273_RS04390 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4273_RS04395 ENOG4105ES5 Histidine kinase G4273_RS04410 ENOG4108YXQ IS66 Orf2 family protein G4273_RS04440 ENOG4108UQV Membrane G4273_RS04445 ENOG4105CXN decarboxylase G4273_RS04450 ENOG4105EAA nucleoside G4273_RS04465 ENOG4105CEN a g-specific adenine glycosylase G4273_RS04475 ENOG41090ED Protein with unknown function (DUF469) G4273_RS04485 ENOG4105K33 Periplasmic Protein G4273_RS04490 ENOG4105HDK L-asparaginase G4273_RS04495 ENOG4106MH3 alpha helix chain G4273_RS04505 ENOG4105CSA Coproporphyrinogen iii oxidase G4273_RS04510 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G4273_RS04520 ENOG4108VIA integral membrane protein G4273_RS04525 ENOG4105DFA alanine racemase domain protein G4273_RS04530 ENOG4105CZX twitching motility protein G4273_RS04545 ENOG4105D7Z glutathione synthase G4273_RS04550 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G4273_RS04555 ENOG4105RWS endonuclease I G4273_RS04565 ENOG4107QNK )-transporter G4273_RS04585 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) G4273_RS04600 ENOG4108K0D peptidase, M48 G4273_RS04605 ENOG4105CV1 Transketolase (EC 2.2.1.1) G4273_RS04610 ENOG4105EPW hflc protein G4273_RS04615 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia G4273_RS04620 ENOG4105CTS PTS system mannitol-specific G4273_RS04625 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein G4273_RS04630 ENOG4108Q8A Fructose-1,6-bisphosphatase G4273_RS04640 ENOG4107Z1W Fructose transport system kinase G4273_RS04645 ENOG4108JJB ABC transporter G4273_RS04680 ENOG4105D2N Aldolase G4273_RS04685 ENOG4105D64 Mechanosensitive ion channel G4273_RS04690 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G4273_RS04695 ENOG4105MPN Membrane G4273_RS04705 ENOG4105D5P Methylmalonyl-coA mutase G4273_RS04725 ENOG4108JQ1 Dehydrogenase G4273_RS04735 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G4273_RS04755 ENOG4107RAQ aminopeptidase G4273_RS04760 ENOG4105D0A hydroxylase G4273_RS04765 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G4273_RS04775 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G4273_RS04790 ENOG4105CS2 ec 3.2.1.21 G4273_RS04800 ENOG4108UT2 hemolysin iii G4273_RS04805 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G4273_RS04810 ENOG4105Y75 tpr repeat protein G4273_RS04815 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB G4273_RS04820 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) G4273_RS04825 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G4273_RS04830 ENOG4105T95 Thiol disulfide interChange protein G4273_RS04835 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G4273_RS04845 ENOG4105CRK lysyL-tRNA synthetase G4273_RS04865 ENOG4105C2W permease G4273_RS04870 ENOG4105BZ8 glutamate synthase G4273_RS04875 ENOG4108R8B oxidoreductase Fe-S subunit G4273_RS04880 ENOG4105C7N Xanthine uracil vitamin C permease G4273_RS04885 ENOG4107QUY Guanine deaminase G4273_RS04890 ENOG4105C2W permease G4273_RS04895 ENOG4105C7W Xanthine dehydrogenase G4273_RS04900 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase G4273_RS04905 ENOG4107UUR Chlorohydrolase aminohydrolase G4273_RS04910 ENOG4105BZ8 glutamate synthase G4273_RS04915 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase G4273_RS04920 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC G4273_RS04925 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family G4273_RS04930 ENOG4105C5B carbamate kinase G4273_RS04940 ENOG4107S4Y M20 DapE family protein YgeY G4273_RS04945 ENOG4107RCH Diaminopropionate ammonia-lyase G4273_RS04950 ENOG4105IW6 Carbamoyltransferase G4273_RS04955 ENOG4108JUB Transcriptional regulator G4273_RS04960 ENOG4108UTP (2Fe-2S)-binding domain protein G4273_RS04965 ENOG4108HR6 Dehydrogenase G4273_RS04970 ENOG4105C7W Xanthine dehydrogenase G4273_RS04975 ENOG4108K5P (LipO)protein G4273_RS04985 ENOG4108MHD transport protein G4273_RS04990 ENOG4105CHU acetyl-coa acetyltransferase G4273_RS05000 ENOG4105CHR reductase G4273_RS05005 ENOG4107QNK )-transporter G4273_RS05015 ENOG4105RQF LysR family Transcriptional regulator G4273_RS05025 ENOG41060NJ transcriptional regulator G4273_RS05040 ENOG4105CPC Aldo Keto reductase G4273_RS05045 ENOG4105SUV lipoprotein YgdR G4273_RS05050 ENOG4105EE5 Membrane protein terC G4273_RS05065 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase G4273_RS05080 ENOG4105IPU prepilin peptidase dependent protein A G4273_RS05085 ENOG4105JCS prepilin peptidase dependent protein G4273_RS05090 ENOG4105SEN Protein of unknown function (DUF2509) G4273_RS05095 ENOG4105RVB Prepilin peptidase dependent protein c G4273_RS05100 ENOG4105DSY exodeoxyribonuclease V, gamma G4273_RS05105 ENOG4107QXK peptidase G4273_RS05110 ENOG4107QKA exodeoxyribonuclease V beta G4273_RS05115 ENOG4107QYX exodeoxyribonuclease v alpha G4273_RS05120 ENOG4108EKC n-acetylglutamate synthase G4273_RS05125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4273_RS05135 ENOG4105CI1 PTS System G4273_RS05140 ENOG4105C87 Aminotransferase class I and II G4273_RS05145 ENOG4105C2X Arabinose 5-phosphate isomerase G4273_RS05255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G4273_RS05265 ENOG4108ZG0 Ompa motb domain protein G4273_RS05305 ENOG4105CA3 membrane-bound lytic murein transglycosylase G4273_RS05310 ENOG4105CUZ uba thif-type nad fad binding protein G4273_RS05315 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) G4273_RS05320 ENOG4105C9B Cysteine desulfurase G4273_RS05325 ENOG4105M5B (LipO)protein G4273_RS05330 ENOG4105ETT transcriptional Regulator, LysR family G4273_RS05335 ENOG4105M08 Membrane G4273_RS05340 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) G4273_RS05345 ENOG4107EDW L-fucose operon activator G4273_RS05355 ENOG4105CMG Carbohydrate kinase G4273_RS05365 ENOG4105EDR glucose galactose transporter G4273_RS05370 ENOG4107W7X Aldolase G4273_RS05375 ENOG4105C0A alcohol dehydrogenase G4273_RS05385 ENOG4105EJQ L-serine dehydratase G4273_RS05390 ENOG4105C44 Serine transporter G4273_RS05395 ENOG4105EWT decarboxylase family G4273_RS05410 ENOG4105WP7 tRNA pseudouridine synthase C G4273_RS05415 ENOG4105DR9 pseudouridine synthase G4273_RS05420 ENOG4105QDK Flavodoxin G4273_RS05425 ENOG4105DJB Major Facilitator Superfamily G4273_RS05430 ENOG4105EQX glucarate dehydratase G4273_RS05435 ENOG4105EQX glucarate dehydratase G4273_RS05440 ENOG4105BZU Histidine kinase G4273_RS05450 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G4273_RS05455 ENOG4105DXN mazG family G4273_RS05470 ENOG4105HA9 of methanol dehydrogenase type G4273_RS05480 ENOG4105HA9 of methanol dehydrogenase type G4273_RS05490 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G4273_RS05495 ENOG4108CWB sugar kinase ygcE G4273_RS05500 ENOG4108ITV Inner membrane protein yqcE G4273_RS05505 ENOG4105CHR reductase G4273_RS05510 ENOG4107R3A FAD linked oxidase domain protein G4273_RS05515 ENOG4105C54 Major Facilitator superfamily G4273_RS05520 ENOG4106IKH Electron transfer flavoprotein G4273_RS05525 ENOG4105YBM electron transfer flavoprotein subunit ygcQ G4273_RS05530 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator G4273_RS05535 ENOG4105WQV ferredoxin-like protein G4273_RS05540 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G4273_RS05545 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase G4273_RS05550 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G4273_RS05565 ENOG4107635 Hok Gef family protein G4273_RS05570 ENOG4108MXK alkaline phosphatase isozyme conversion G4273_RS05590 ENOG4105N0Z inner membrane protein ygbE G4273_RS05610 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) G4273_RS05625 ENOG4108K5P (LipO)protein G4273_RS05630 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4273_RS05645 ENOG4105C6Z Gluconate G4273_RS05650 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G4273_RS05655 ENOG4105FB2 class II Aldolase G4273_RS05660 ENOG4105G63 Type III effector Hrp-dependent G4273_RS05670 ENOG4105MVE transcriptional regulator G4273_RS05675 ENOG4105MEW serine threonine protein phosphatase G4273_RS05685 ENOG41067CV Integrase G4273_RS05725 ENOG4105VXR cytoplasmic protein G4273_RS05735 ENOG4108JUA Transcriptional regulator G4273_RS05740 ENOG4105C45 hydrogenase expression formation protein (HypE) G4273_RS05745 ENOG4105CQS hydrogenase expression formation protein HypD G4273_RS05750 ENOG41083WG hydrogenase assembly chaperone G4273_RS05755 ENOG4107RSS Hydrogenase accessory protein HypB G4273_RS05760 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G4273_RS05765 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA G4273_RS05770 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) G4273_RS05775 ENOG4107R30 NADH dehydrogenase G4273_RS05780 ENOG4107TDF Formate hydrogenlyase subunit 4 G4273_RS05785 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G4273_RS05790 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit G4273_RS05795 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit G4273_RS05800 ENOG4105I6X formate hydrogenlyase maturation G4273_RS05805 ENOG4108MG9 hydrogenase 3 maturation protease G4273_RS05815 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) G4273_RS05820 ENOG4108Z3N Transcriptional regulator G4273_RS05830 ENOG4108RC0 Electron transport protein G4273_RS05835 ENOG4105C8H hydrogenase maturation protein Hypf G4273_RS05850 ENOG4108JUA Transcriptional regulator G4273_RS05855 ENOG4105C2X Arabinose 5-phosphate isomerase G4273_RS05860 ENOG410804X Transcriptional regulator G4273_RS05865 ENOG4105J92 DNA-binding transcriptional activator GutM G4273_RS05870 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase G4273_RS05875 ENOG4105VI0 Pts system, glucitol sorbitol-specific G4273_RS05880 ENOG4105DZY Pts system, glucitol sorbitol-specific G4273_RS05885 ENOG410787A Pts system, glucitol sorbitol-specific G4273_RS05890 ENOG4105CVE Lytic murein transglycosylase G4273_RS05895 ENOG4107TH8 cina domain protein G4273_RS05915 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) G4273_RS05945 ENOG4107VXZ Hydrolase G4273_RS05950 ENOG4105W39 Membrane G4273_RS05975 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4273_RS05980 ENOG4105CW7 secretion protein, HlyD family G4273_RS05985 ENOG4105NTK Transcriptional repressor Mpra G4273_RS05990 ENOG4105ZED uncharacterized protein ygaH G4273_RS05995 ENOG4108UMN azlc family G4273_RS06005 ENOG4105GIJ Glycine betaine G4273_RS06010 ENOG4108HQS Glycine betaine G4273_RS06015 ENOG4108IJ7 Glycine betaine G4273_RS06020 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4273_RS06025 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4273_RS06035 ENOG4105WAZ (Glutaredoxin-like protein) NrdH G4273_RS06040 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G4273_RS06050 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) G4273_RS06055 ENOG4108WMJ Protein of unknown function (DUF2002) G4273_RS06060 ENOG4108RNS Exports L-alanine (By similarity) G4273_RS06065 ENOG4108X73 DNA- binding protein G4273_RS06070 ENOG4108V62 Rhodanese domain protein G4273_RS06075 ENOG41080HT Transcriptional regulator, arsr family G4273_RS06080 ENOG4105VPI YqaE family transport protein G4273_RS06085 ENOG4109066 lysm domain bon superfamily protein G4273_RS06090 ENOG4108PVQ transcriptional regulator G4273_RS06095 ENOG4105C85 amino acid G4273_RS06100 ENOG4108JPW Aminotransferase G4273_RS06105 ENOG4105C26 Dehydrogenase G4273_RS06110 ENOG4105D5U fad dependent oxidoreductase G4273_RS06130 ENOG4108Z1B Cyclase dehydrase G4273_RS06140 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G4273_RS06145 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G4273_RS06160 ENOG4108JU6 CBS domain protein G4273_RS06165 ENOG4106KVJ cytochrome C assembly protein G4273_RS06170 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G4273_RS06195 ENOG41090EK ompa motb domain protein G4273_RS06200 ENOG4108KHX Diguanylate cyclase G4273_RS06205 ENOG4108WS1 G4273_RS06210 ENOG4105QP9 Protein of unknown function (DUF2799) G4273_RS06215 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G4273_RS06220 ENOG4105EHE chorismate mutase- prephenate dehydrogenase G4273_RS06225 ENOG4105CQC Prephenate dehydratase G4273_RS06235 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA G4273_RS06240 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G4273_RS06245 ENOG4105C34 Pseudouridine synthase G4273_RS06250 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G4273_RS06255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G4273_RS06290 ENOG4105CSH Transporter G4273_RS06295 ENOG4105T42 (LipO)protein G4273_RS06300 ENOG4105JIM Phosphatidylserine synthase G4273_RS06305 ENOG4105CD5 CoA-binding domain protein G4273_RS06310 ENOG4106IUH DTW domain containing protein G4273_RS06315 ENOG4105K63 Thioredoxin G4273_RS06320 ENOG4105EIB trna rrna methyltransferase G4273_RS06340 ENOG41090KR LysR family transcriptional Regulator G4273_RS06345 ENOG4105C1J atp-dependent rna helicase G4273_RS06355 ENOG4108IYU L-aspartate oxidase G4273_RS06365 ENOG4105EMN RNA polymerase sigma factor G4273_RS06370 ENOG41069PW sigma-e factor negative regulatory protein G4273_RS06375 ENOG4105VQK sigma E regulatory protein, MucB RseB G4273_RS06380 ENOG4105WMJ Positive regulator of sigma E, RseC MucC G4273_RS06390 ENOG4105C3F Signal peptidase i G4273_RS06410 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G4273_RS06425 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G4273_RS06430 ENOG4106G6Q Transcriptional regulator G4273_RS06435 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB G4273_RS06440 ENOG4108Z6B deaminase G4273_RS06450 ENOG4108ETH Formylglycinamide ribotide synthetase G4273_RS06455 ENOG4107WP9 Histidine kinase G4273_RS06460 ENOG4108SKK alpha helix protein G4273_RS06465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4273_RS06475 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G4273_RS06485 ENOG4108NZE NAGC-like transcriptional regulator G4273_RS06490 ENOG4107HQ7 repeat protein G4273_RS06495 ENOG4105FCA ABC transporter periplasmic-binding protein YphF G4273_RS06500 ENOG4108F37 ATP-binding component of a transport system G4273_RS06505 ENOG4105CNN ABC, transporter G4273_RS06510 ENOG4105CPQ Dehydrogenase G4273_RS06515 ENOG4108ZKT aldose 1-epimerase G4273_RS06520 ENOG4108SB3 DoxX Family G4273_RS06525 ENOG4105D8G Major Facilitator superfamily G4273_RS06530 ENOG4108MN2 Stationary phase inducible protein CsiE G4273_RS06535 ENOG4107XM9 (LipO)protein G4273_RS06540 ENOG4105ECY inositol monophosphatase G4273_RS06560 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G4273_RS06580 ENOG4108ZIT Ferredoxin, 2FE-2S G4273_RS06585 ENOG4105WVQ Fe-S assembly protein IscX G4273_RS06595 ENOG4105YYA enhanced serine sensitivity protein SseB G4273_RS06605 ENOG4105KHC sulfurtransferase G4273_RS06610 ENOG4105DN3 alpha-2-macroglobulin domain protein G4273_RS06615 ENOG4108JQB penicillin-binding protein 1C G4273_RS06645 ENOG4105N21 Membrane G4273_RS06660 ENOG4105VPD cellular component movement G4273_RS06685 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G4273_RS06710 ENOG41066DY Membrane G4273_RS06715 ENOG4108ZMA Outer membrane lipoprotein G4273_RS06720 ENOG41062G3 Protein of unknown function (DUF2633) G4273_RS06730 ENOG4105BZU Histidine kinase G4273_RS06735 ENOG4105C9X ppx gppa phosphatase G4273_RS06740 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G4273_RS06745 ENOG4108V3E phosphoribosylglycinamide formyltransferase G4273_RS06750 ENOG4105CXB phosphoribosylaminoimidazole synthetase G4273_RS06760 ENOG4105C2W permease G4273_RS06765 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) G4273_RS06770 ENOG4105K89 arsenate reductase G4273_RS06775 ENOG4105ERG peptidase m48, ste24p G4273_RS06780 ENOG4105C02 permease G4273_RS06785 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G4273_RS06790 ENOG4105RH4 Glycine cleavage system transcriptional repressor G4273_RS06800 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G4273_RS06810 ENOG4105CGZ zinc metallopeptidase G4273_RS06820 ENOG4106KED esterase YpfH G4273_RS06835 ENOG4105KUZ arsenate reductase G4273_RS06845 ENOG4105BZS acriflavin resistance protein G4273_RS06850 ENOG4105BZU Histidine kinase G4273_RS06855 ENOG4105BZ8 glutamate synthase G4273_RS06865 ENOG4108PVD exported protein G4273_RS06870 ENOG4105CV1 Transketolase (EC 2.2.1.1) G4273_RS06875 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G4273_RS06880 ENOG4105C6K Malic enzyme G4273_RS06885 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place G4273_RS06890 ENOG4106S4J ethanolamine utilization protein EutP G4273_RS06895 ENOG4105NDK ethanolamine utilization protein G4273_RS06900 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase G4273_RS06905 ENOG4107WUY phosphate acetyltransferase G4273_RS06910 ENOG4105KNY Microcompartments protein G4273_RS06915 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml G4273_RS06920 ENOG4108EKI Dehydrogenase G4273_RS06925 ENOG4107RWI ethanolamine utilization protein eutJ G4273_RS06930 ENOG4105C0A alcohol dehydrogenase G4273_RS06935 ENOG4105ENY Ethanolamine utilization protein eutH G4273_RS06940 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase G4273_RS06945 ENOG4105CPD ethanolamine ammonia-lyase G4273_RS06955 ENOG4106D67 ethanolamine utilization protein G4273_RS06960 ENOG4108X49 Ethanolamine utilization protein EutK G4273_RS06965 ENOG4108K3Z AraC family transcriptional regulator G4273_RS06975 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase G4273_RS06985 ENOG4105QZU Inner membrane protein YfeZ G4273_RS06990 ENOG4105E7K (LipO)protein G4273_RS06995 ENOG4105EZR dyp-type peroxidase family protein G4273_RS07005 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G4273_RS07010 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G4273_RS07015 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein G4273_RS07020 ENOG4108I5D sulfate abc transporter G4273_RS07025 ENOG4105ECW sulfate abc transporter G4273_RS07030 ENOG4108IJ6 ABC transporter G4273_RS07035 ENOG4105C6T cysteine synthase G4273_RS07040 ENOG4105M0Y G4273_RS07050 ENOG4105C5Y PTS System G4273_RS07055 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G4273_RS07065 ENOG4105C6T cysteine synthase G4273_RS07085 ENOG4105VRT cytoplasmic protein G4273_RS07090 ENOG4105DHU Bile acid G4273_RS07095 ENOG4108M0I Transcriptional regulator G4273_RS07100 ENOG4108NFH Sugar hydrolase G4273_RS07105 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) G4273_RS07110 ENOG4105EAA nucleoside G4273_RS07120 ENOG4105CN8 Transcriptional regulator G4273_RS07150 ENOG4105GXM Putative transcription regulator (DUF1323) G4273_RS07155 ENOG4105HZG regulatoR G4273_RS07170 ENOG4108KMM Diguanylate cyclase G4273_RS07175 ENOG4105D9N nucleoside G4273_RS07185 ENOG4109076 Conserved Protein G4273_RS07200 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) G4273_RS07205 ENOG410863U PTS System G4273_RS07210 ENOG4105DC7 peptidase M24 G4273_RS07215 ENOG4105CN9 Peptidase m42 family protein G4273_RS07220 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G4273_RS07225 ENOG4108CIP transcriptional regulator G4273_RS07230 ENOG4105DY9 regulatoR G4273_RS07235 ENOG4108HRK Histidine kinase G4273_RS07240 ENOG4105CHM Aminotransferase G4273_RS07250 ENOG4105D1S lipid A biosynthesis G4273_RS07255 ENOG4105W9M Membrane G4273_RS07265 ENOG4108V08 YfdX protein G4273_RS07275 ENOG4105CFN oxalyl-CoA decarboxylase G4273_RS07280 ENOG4108N2Y auxin Efflux G4273_RS07285 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G4273_RS07290 ENOG4105BZU Histidine kinase G4273_RS07295 ENOG4108WQH regulatoR G4273_RS07300 ENOG4105CW7 secretion protein, HlyD family G4273_RS07305 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4273_RS07310 ENOG4105BZC d-serine deaminase G4273_RS07320 ENOG4105W8I Transcriptional regulator G4273_RS07330 ENOG4105S64 Formate nitrite transporter G4273_RS07335 ENOG410903C (LipO)protein G4273_RS07340 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation G4273_RS07345 ENOG4105KZW UPF0381 protein G4273_RS07360 ENOG4108BY2 phosphohistidine phosphatase G4273_RS07370 ENOG4106PG1 outer membrane usher protein G4273_RS07375 ENOG4108FZ9 Chaperone G4273_RS07380 ENOG4105NEV Fimbrial G4273_RS07385 ENOG4105UGQ Fimbrial G4273_RS07390 ENOG4105US4 fimbrial-like protein yfcP G4273_RS07410 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G4273_RS07415 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) G4273_RS07420 ENOG4105EJ9 Membrane G4273_RS07425 ENOG4108BPE -transporting atpase G4273_RS07430 ENOG4105MH2 YfcL protein G4273_RS07440 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G4273_RS07445 ENOG4105F9N Major Facilitator Superfamily G4273_RS07450 ENOG4106WZ1 flagella biosynthesis regulator G4273_RS07460 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G4273_RS07470 ENOG4105DQR SNARE associated Golgi G4273_RS07480 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G4273_RS07485 ENOG4108S3P Sporulation domain protein G4273_RS07490 ENOG4105E96 Colicin v production protein G4273_RS07495 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G4273_RS07500 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G4273_RS07505 ENOG4105E89 ABC transporter G4273_RS07510 ENOG4105E89 ABC transporter G4273_RS07515 ENOG4105DSP amino acid AbC transporter G4273_RS07520 ENOG4106YG3 ABC transporter G4273_RS07525 ENOG4108JEH abc transporter atp-binding protein G4273_RS07530 ENOG4105DNE Transposase G4273_RS07535 ENOG4105ECP epimerase G4273_RS07540 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase G4273_RS07545 ENOG4105CYM Glutathione S-transferase G4273_RS07550 ENOG4108SHQ Glutathione S-transferase G4273_RS07555 ENOG4108RE9 Phosphodiesterase G4273_RS07560 ENOG4105PTV Nudix Hydrolase G4273_RS07565 ENOG4105CSX c4-dicarboxylate anaerobic carrier G4273_RS07570 ENOG4105C6K Malic enzyme G4273_RS07575 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G4273_RS07585 ENOG4105XWI UPF0304 protein G4273_RS07590 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 G4273_RS07595 ENOG4107QWE )-transporter G4273_RS07605 ENOG4105CHM Aminotransferase G4273_RS07610 ENOG4107NQ8 LysR family Transcriptional regulator G4273_RS07630 ENOG4105GKE subunit e G4273_RS07635 ENOG4107QIZ NADH dehydrogenase G4273_RS07640 ENOG4108IEH NADH dehydrogenase subunit g G4273_RS07655 ENOG4107UFS subunit j G4273_RS07665 ENOG4105D65 subunit l G4273_RS07670 ENOG4105C8S subunit m G4273_RS07680 ENOG4105GDX Domain of unknown function (DUF1877) G4273_RS07685 ENOG4107VAM peptidase, m28 G4273_RS07690 ENOG4105CP2 von willebrand factor, type a G4273_RS07700 ENOG4107YB6 acetyltransferase, (GNAT) family G4273_RS07705 ENOG4105TNS Conserved Protein G4273_RS07710 ENOG4105E4F Isochorismate synthase G4273_RS07725 ENOG4108IPT Naphthoate synthase G4273_RS07730 ENOG4105DNI Converts SHCHC to OSB (By similarity) G4273_RS07735 ENOG4105CEY Amp-dependent synthetase and ligase G4273_RS07740 ENOG4106GZG polymyxin resistance protein B G4273_RS07755 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) G4273_RS07790 ENOG4108UII YfaZ family G4273_RS07795 ENOG4108EWA cinA-like protein G4273_RS07800 ENOG4107258 Transcriptional regulator G4273_RS07805 ENOG4105CXK mandelate racemase muconate lactonizing G4273_RS07810 ENOG4105CSP Major Facilitator Superfamily G4273_RS07825 ENOG4105DNE Transposase G4273_RS07830 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4273_RS07840 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A G4273_RS07845 ENOG4105CXY transporter G4273_RS07850 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G4273_RS07855 ENOG4105FQR PH-inducible protein involved in stress response G4273_RS07860 ENOG4105XPH Ferredoxin G4273_RS07865 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4273_RS07870 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4273_RS07875 ENOG4107GHC outer membrane autotransporter G4273_RS07885 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4273_RS07890 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) G4273_RS07895 ENOG4108QJJ Protein of unknown function (DUF1175) G4273_RS07900 ENOG4107S52 alpha-2-macroglobulin domain protein G4273_RS07905 ENOG41081SK signal peptide protein G4273_RS07910 ENOG4105EDV vault protein G4273_RS07915 ENOG4105CHU acetyl-coa acetyltransferase G4273_RS07920 ENOG4105CRW Short chain fatty acid transporter G4273_RS07925 ENOG4107QNJ CoA-transferase subunit B G4273_RS07930 ENOG4107QP7 CoA-transferase subunit A G4273_RS07935 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4273_RS07940 ENOG4105BZU Histidine kinase G4273_RS07945 ENOG4105BZU Histidine kinase G4273_RS07950 ENOG41068CG regulatoR G4273_RS07955 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC G4273_RS07960 ENOG4105FCK Membrane G4273_RS07965 ENOG4105CJ2 (LipO)protein G4273_RS07970 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G4273_RS07975 ENOG4105CF1 Alkylated DNA repair protein G4273_RS07980 ENOG4105IBP Cyclic peptide transporter G4273_RS07985 ENOG4105DWT malate dehydrogenase (quinone) G4273_RS08000 ENOG4108ZNS ferredoxin-type protein NapF G4273_RS08005 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase G4273_RS08015 ENOG4108BGM Quinol dehydrogenase periplasmic component G4273_RS08020 ENOG4105GXZ Ferredoxin-type protein NapH G4273_RS08025 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) G4273_RS08030 ENOG4105CUW cytochrome C-TYPE protein G4273_RS08035 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) G4273_RS08040 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) G4273_RS08045 ENOG41060IM Heme exporter protein G4273_RS08050 ENOG4105X3C heme exporter protein G4273_RS08060 ENOG4105DA4 cytochrome c-type biogenesis protein G4273_RS08065 ENOG4107QX9 Thiol disulfide interChange protein G4273_RS08070 ENOG4105KWW Biogenesis protein G4273_RS08075 ENOG4105WH1 Two component transcriptional regulator luxr family G4273_RS08090 ENOG4105E68 Sulfatase G4273_RS08110 ENOG4105CFI type iii restriction protein res subunit G4273_RS08115 ENOG4105I08 Pseudouridine synthase G4273_RS08120 ENOG4105C2C drug resistance transporter, Bcr CflA G4273_RS08125 ENOG4105HG6 G4273_RS08130 ENOG4108JQ5 ABC transporter G4273_RS08135 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G4273_RS08140 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G4273_RS08145 ENOG4105E43 Extracellular solute-binding protein, family 5 G4273_RS08150 ENOG4105CXC rtn protein G4273_RS08155 ENOG4107TT5 NLP P60 protein G4273_RS08160 ENOG41076MN Phosphoesterase, PA-phosphatase related G4273_RS08165 ENOG4105CKI cobalamin synthesis protein G4273_RS08170 ENOG4105DEI Mannitol dehydrogenase G4273_RS08180 ENOG4105KRS Proteinase inhibitor G4273_RS08185 ENOG4105S8Q sugar efflux transporter G4273_RS08190 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein G4273_RS08195 ENOG4105DE4 1-phosphofructokinase G4273_RS08200 ENOG4105DM4 PTS System G4273_RS08205 ENOG4105DD7 kinase (PfkB family G4273_RS08210 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) G4273_RS08215 ENOG4105D9N nucleoside G4273_RS08220 ENOG4108Y4K DNA-binding transcriptional activator G4273_RS08230 ENOG4105DD7 kinase (PfkB family G4273_RS08240 ENOG4105HMI Membrane G4273_RS08245 ENOG4105DUM transcriptional regulator, lysR family G4273_RS08250 ENOG4108IQI permease G4273_RS08255 ENOG4105D05 Receptor G4273_RS08260 ENOG4105C4W S-formylglutathione hydrolase G4273_RS08270 ENOG4105DHF Membrane G4273_RS08275 ENOG41060NJ transcriptional regulator G4273_RS08280 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator G4273_RS08285 ENOG4105C2J ABC transporter G4273_RS08290 ENOG4108HWV )-transporter G4273_RS08295 ENOG4107SJI Dehydrogenase G4273_RS08300 ENOG4105BZ8 glutamate synthase G4273_RS08305 ENOG4105Y9N Membrane G4273_RS08310 ENOG4107GZ4 SanA protein G4273_RS08320 ENOG41067MG lrgb family G4273_RS08330 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) G4273_RS08340 ENOG4105ETP RND efflux system, outer membrane lipoprotein G4273_RS08345 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G4273_RS08350 ENOG4105KHU inner membrane protein YohD G4273_RS08355 ENOG41069YE inner membrane protein yohC G4273_RS08360 ENOG41061WM D-Alanyl-D-Alanine G4273_RS08365 ENOG4105CXG d-lactate dehydrogenase G4273_RS08370 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G4273_RS08375 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system G4273_RS08380 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component G4273_RS08385 ENOG4108IJ8 ABC transporter G4273_RS08390 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component G4273_RS08400 ENOG4108XDN Transcriptional regulator G4273_RS08405 ENOG4108HRK Histidine kinase G4273_RS08410 ENOG4108NEV two component transcriptional regulator, LytTR family G4273_RS08415 ENOG4108W15 Protein of unknown function (DUF1456) G4273_RS08420 ENOG4108YCW (LipO)protein G4273_RS08425 ENOG410903U zinc ion binding G4273_RS08430 ENOG4105DEG Vwa containing coxe family protein G4273_RS08435 ENOG4105RD5 G4273_RS08440 ENOG4105KKX ATPase associated with various cellular activities aaa_5 G4273_RS08450 ENOG4108KDT Molybdate metabolism regulator G4273_RS08455 ENOG4108KDT Molybdate metabolism regulator G4273_RS08465 ENOG4105D1F ATP-binding protein G4273_RS08470 ENOG41067AK Protein of unknown function (DUF2574) G4273_RS08475 ENOG41063W2 Fimbrial protein G4273_RS08480 ENOG4108MQF Chaperone G4273_RS08485 ENOG4105CW0 outer membrane usher protein G4273_RS08490 ENOG410662B Type-1 fimbrial protein G4273_RS08495 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly G4273_RS08515 ENOG4105DWF phosphomethylpyrimidine kinase G4273_RS08520 ENOG4108UQ1 hydrolase, family 25 G4273_RS08525 ENOG4105FDP GntR family transcriptional regulator G4273_RS08530 ENOG4108TFM Kinase, PfkB family G4273_RS08535 ENOG4108KD5 ADP-ribosylation crystallin J1 G4273_RS08540 ENOG4105EAA nucleoside G4273_RS08545 ENOG4105EIE fructose-bisphosphate aldolase G4273_RS08550 ENOG4105D2N Aldolase G4273_RS08555 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of G4273_RS08560 ENOG41082GB PTS system galactitol-specific transporter subunit IIA G4273_RS08565 ENOG41090UW PTS System G4273_RS08570 ENOG4105DT3 PTS system, galactitol-specific IIc component G4273_RS08575 ENOG4107WTH Galactitol-1-phosphate dehydrogenase G4273_RS08590 ENOG41076Z6 Uncharacterized protein yegR G4273_RS08595 ENOG4105CFP Peptidase U32 G4273_RS08620 ENOG4105KWI UPF0339 protein G4273_RS08625 ENOG4105E3W Two component transcriptional regulator (Winged helix family G4273_RS08630 ENOG4105EB3 Histidine kinase G4273_RS08640 ENOG4105BZS acriflavin resistance protein G4273_RS08645 ENOG4105BZS acriflavin resistance protein G4273_RS08650 ENOG4105ENT Efflux transporter rnd family, mfp subunit G4273_RS08665 ENOG4108M24 von Willebrand factor, type A G4273_RS08670 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase G4273_RS08675 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding G4273_RS08680 ENOG4105R8A Heat shock protein G4273_RS08685 ENOG4105D03 DNA-3-methyladenine glycosylase II G4273_RS08695 ENOG4105DBI uridine monophosphokinase G4273_RS08705 ENOG4108GAE asmA family G4273_RS08710 ENOG4105EE5 Membrane protein terC G4273_RS08720 ENOG4105DAY polysaccharide export protein G4273_RS08725 ENOG4105KJF protein tyrosine phosphatase G4273_RS08730 ENOG4105D75 Capsular exopolysaccharide family G4273_RS08735 ENOG41090RK glycosyl transferase G4273_RS08740 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB G4273_RS08745 ENOG4107RXY Glycosyl transferase G4273_RS08750 ENOG4108NYJ Colanic acid G4273_RS08755 ENOG4105ECJ Glycosyl Transferase G4273_RS08760 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF G4273_RS08765 ENOG4105C0K Gdp-mannose 4,6-dehydratase G4273_RS08770 ENOG4105C30 Nad-dependent epimerase dehydratase G4273_RS08775 ENOG4105FGF GDP-mannose mannosyl hydrolase G4273_RS08780 ENOG4106CD9 glycosyl transferase group 1 G4273_RS08785 ENOG4105CJT Mannose-1-phosphate guanylyltransferase G4273_RS08790 ENOG4107QKV phosphomannomutase G4273_RS08795 ENOG4105D3Q Sugar transferase G4273_RS08800 ENOG4105PSV Polysaccharide Biosynthesis Protein G4273_RS08805 ENOG4105C74 pyruvyl transferase G4273_RS08810 ENOG4107T8Q Glycosyl transferase (Group 1 G4273_RS08815 ENOG4105G1A colanic acid biosynthesis protein G4273_RS08820 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G4273_RS08825 ENOG4105C1B dTDP-glucose 4-6-dehydratase G4273_RS08830 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase G4273_RS08835 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G4273_RS08840 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase G4273_RS08845 ENOG4108MX3 Polysaccharide Biosynthesis Protein G4273_RS08850 ENOG4105K64 Glycosyl transferase, family 2 G4273_RS08860 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G4273_RS08875 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G4273_RS08890 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G4273_RS08895 ENOG4105C6Y Udp-glucose 6-dehydrogenase G4273_RS08920 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G4273_RS08925 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G4273_RS08930 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G4273_RS08935 ENOG4105CIH Imidazole acetol-phosphate transaminase G4273_RS08940 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G4273_RS08955 ENOG4105VTW prevent-host-death family G4273_RS08960 ENOG4105KRQ Addiction module toxin, Txe YoeB family G4273_RS08965 ENOG4107SRH Nad-dependent epimerase dehydratase G4273_RS08970 ENOG4105EQ1 Transcriptional regulator G4273_RS08980 ENOG4105CUB amino acid G4273_RS08985 ENOG4105CUC YeeE YedE family protein G4273_RS08995 ENOG4105CJB Exodeoxyribonuclease I G4273_RS09000 ENOG4105DFP Integrase G4273_RS09020 ENOG4105CKK Glycosyl transferase, family 2 G4273_RS09025 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) G4273_RS09030 ENOG4105DZ1 carboxypeptidase G4273_RS09040 ENOG4105DR8 Membrane G4273_RS09075 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4273_RS09085 ENOG4108YGG dna repair protein G4273_RS09090 ENOG4106549 Antirestriction protein G4273_RS09095 ENOG4106H6R UPF0380 protein G4273_RS09115 ENOG4108YIV G4273_RS09120 ENOG4108F5E vimentin G4273_RS09140 ENOG4105EHG Permease protein G4273_RS09145 ENOG4108F1U ABC transporter G4273_RS09195 ENOG410836F Transposase G4273_RS09230 ENOG41080QX K07048 phosphotriesterase-related protein G4273_RS09245 ENOG4108RVA ribokinase G4273_RS09255 ENOG4105SRB Uncharacterized protein yaiO G4273_RS09260 ENOG4107RMY Bacterial transferase hexapeptide repeat protein G4273_RS09265 ENOG4108PBI Polysaccharide metabolism G4273_RS09270 ENOG4107W19 lmbE family G4273_RS09275 ENOG4105BZV Phosphoadenosine phosphosulfate reductase G4273_RS09280 ENOG4105GTN ParB Domain Protein Nuclease G4273_RS09290 ENOG4108YZT Adenosylcobinamide kinase G4273_RS09305 ENOG4108PXI ErfK YbiS YcfS YnhG G4273_RS09325 ENOG4105WH1 Two component transcriptional regulator luxr family G4273_RS09340 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G4273_RS09345 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) G4273_RS09350 ENOG4105C1G acyl-Coa dehydrogenase G4273_RS09380 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G4273_RS09405 ENOG4108VTW Thioesterase G4273_RS09425 ENOG4105UQX Mate efflux family protein G4273_RS09435 ENOG4107R11 Transcriptional regulator G4273_RS09440 ENOG4106P55 Transcriptional regulator G4273_RS09450 ENOG4105CDY transcriptional regulatory protein G4273_RS09455 ENOG4105FYV Amp nucleosidase G4273_RS09460 ENOG4105CSH Transporter G4273_RS09470 ENOG4105TNG K13735 adhesin invasin G4273_RS09480 ENOG4105TNG K13735 adhesin invasin G4273_RS09485 ENOG4107ZSV Receptor G4273_RS09490 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G4273_RS09510 ENOG4105C0W non-ribosomal peptide synthetase G4273_RS09525 ENOG4105BZ1 (ABC) transporter G4273_RS09530 ENOG4105EYM Major Facilitator superfamily G4273_RS09590 ENOG4108YX2 DNA-binding protein G4273_RS09680 ENOG4105DFP Integrase G4273_RS09685 ENOG4108MEK Metal-binding protein YodA G4273_RS09690 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) G4273_RS09695 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G4273_RS09700 ENOG4105VT2 5-hydroxyisourate hydrolase G4273_RS09705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4273_RS09710 ENOG4107ZY3 Histidine kinase G4273_RS09720 ENOG4105ZIT Porin Gram-negative type G4273_RS09725 ENOG4105Y0K Inner membrane protein YedR G4273_RS09730 ENOG4105EST Metal Dependent Phosphohydrolase G4273_RS09735 ENOG4105DVF Cytosine-specific methyltransferase G4273_RS09740 ENOG41090BB DNA mismatch endonuclease (vsr) G4273_RS09745 ENOG4105FDR Membrane G4273_RS09750 ENOG4105CKW Inner membrane protein yedI G4273_RS09755 ENOG4105VNZ cytoplasmic protein G4273_RS09760 ENOG4105BZU Histidine kinase G4273_RS09765 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase G4273_RS09770 ENOG4105YX3 cellular response to acidity G4273_RS09780 ENOG4107TKS colanic acid capsular biosynthesis activation protein A G4273_RS09785 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G4273_RS09795 ENOG4105CN7 Flagellar biosynthetic protein FliP G4273_RS09800 ENOG4105K0P flagellar biosynthesis protein G4273_RS09805 ENOG4105DD5 Flagellar motor switch protein G4273_RS09810 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G4273_RS09815 ENOG4107ZI8 flagellar basal body-associated protein flil G4273_RS09820 ENOG4105WF4 Flagellar hook-length control protein G4273_RS09825 ENOG4105GSA Flagellar export protein flij G4273_RS09830 ENOG4108JIR Flagellum-specific ATP synthase G4273_RS09835 ENOG41090PJ Flagellar assembly protein G4273_RS09840 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G4273_RS09845 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G4273_RS09855 ENOG410814C multidrug resistance protein G4273_RS09860 ENOG4108V1U phospholipid-binding protein G4273_RS09865 ENOG4108UQN AraC family transcriptional regulator G4273_RS09880 ENOG4108RAV Conserved protein G4273_RS09890 ENOG41066VF YeeE YedE family protein G4273_RS09895 ENOG4108W9D (LipO)protein G4273_RS09900 ENOG4105E5K Alpha-amylase G4273_RS09910 ENOG4105MQ3 flagellar protein FliS G4273_RS09915 ENOG4105DTS flagellar hook-associated G4273_RS09920 ENOG4105I03 Flagellin G4273_RS09925 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4273_RS09930 ENOG4108M9K flagella biosynthesis protein FliZ G4273_RS09935 ENOG4105EAB amino acid AbC transporter G4273_RS09945 ENOG4105E5Q amino acid AbC transporter G4273_RS09950 ENOG4105CDA abc transporter atp-binding protein G4273_RS09955 ENOG4105VJY transcriptional regulator G4273_RS09960 ENOG4105XVG cytoplasmic protein G4273_RS09970 ENOG4105WH1 Two component transcriptional regulator luxr family G4273_RS10000 ENOG4106RHG Yeca family G4273_RS10005 ENOG4105E0U tyrosine-specific transport protein G4273_RS10010 ENOG4105VVZ metal-binding protein G4273_RS10015 ENOG41090A1 ferritin G4273_RS10020 ENOG4105P23 (LipO)protein G4273_RS10030 ENOG4105N4N Protein of unknown function (DUF2766) G4273_RS10035 ENOG4108UEC Ferritin-like protein G4273_RS10040 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator G4273_RS10045 ENOG4105C2J ABC transporter G4273_RS10050 ENOG4105CNN ABC, transporter G4273_RS10055 ENOG4108K4C ec 3.1.3.12 G4273_RS10070 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region G4273_RS10075 ENOG4107RD7 Flagellar Motor Protein, MotA G4273_RS10080 ENOG4105ER2 Ompa motb domain protein G4273_RS10085 ENOG4105CBS Chea signal transduction histidine kinase G4273_RS10090 ENOG4108V3W Chemotaxis protein, CheW G4273_RS10095 ENOG4105C8Q Methyl-accepting chemotaxis G4273_RS10105 ENOG4105BZU Histidine kinase G4273_RS10110 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G4273_RS10115 ENOG4108VYJ response regulator receiver protein G4273_RS10120 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) G4273_RS10125 ENOG4105D00 flagellar biosynthetic protein flhB G4273_RS10130 ENOG4105D7B Flagellar biosynthesis protein flha G4273_RS10135 ENOG4105W13 flagellar protein G4273_RS10145 ENOG4106ZCM YecM protein G4273_RS10155 ENOG4105CUW cytochrome C-TYPE protein G4273_RS10160 ENOG4108J2R molybdopterin oxidoreductase G4273_RS10165 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) G4273_RS10175 ENOG4105WJG Glutathione G4273_RS10180 ENOG41081XQ Conserved Protein G4273_RS10185 ENOG4105D3W isochorismatase G4273_RS10195 ENOG4108TIT dATP pyrophosphohydrolase G4273_RS10200 ENOG4105CDY transcriptional regulatory protein G4273_RS10210 ENOG4107S01 Repressor protein MetJ G4273_RS10230 ENOG4105FAV ABC, transporter G4273_RS10240 ENOG4105NXV High-affinity zinc uptake system protein G4273_RS10245 ENOG4105DR5 peptidase G4273_RS10250 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase G4273_RS10255 ENOG4105CA9 Pyruvate kinase G4273_RS10260 ENOG4106KNT transcriptional regulator G4273_RS10265 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G4273_RS10270 ENOG4105C01 Dihydroxy-acid dehydratase G4273_RS10275 ENOG4108UHU Aldolase G4273_RS10285 ENOG4105X2V dna damage-inducible protein G4273_RS10295 ENOG4108Q2J Inner membrane protein YebE G4273_RS10300 ENOG4105CUG Oligopeptidase b G4273_RS10305 ENOG4105UMD exodeoxyribonuclease X G4273_RS10310 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G4273_RS10315 ENOG4105MPK DNA polymerase III subunit theta G4273_RS10320 ENOG4105FXM Copper resistance protein G4273_RS10325 ENOG4108PNC copper resistance G4273_RS10330 ENOG4105NKT exported protein G4273_RS10335 ENOG4108R1E Serine threonine protein phosphatase 1 G4273_RS10340 ENOG4105UVW uncharacterized protein yebW G4273_RS10345 ENOG4105WT8 Protein of unknown function (DUF1480) G4273_RS10355 ENOG4105DY2 Paraquat-inducible protein b G4273_RS10360 ENOG4105H2K paraquat-inducible protein a G4273_RS10365 ENOG4108ZGC gaf domain protein G4273_RS10375 ENOG4105CN1 protease G4273_RS10385 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4273_RS10390 ENOG4105J4Q Transcriptional regulator G4273_RS10395 ENOG4105TIK G4273_RS10405 ENOG4105Q3Y exported protein G4273_RS10420 ENOG4105DHI Methyltransferase G4273_RS10435 ENOG4105F3R pts system mannose fructose sorbose family iid G4273_RS10440 ENOG4105ETZ PTS System G4273_RS10445 ENOG4105DAS pts system G4273_RS10450 ENOG4105EE5 Membrane protein terC G4273_RS10455 ENOG4107XTP (EAL) domain protein G4273_RS10460 ENOG4105EJQ L-serine dehydratase G4273_RS10470 ENOG4105CRQ synthase (Component I) G4273_RS10480 ENOG4105V2F Uncharacterized protein yoac G4273_RS10485 ENOG4105M4H endoribonuclease L-psp G4273_RS10490 ENOG4105DVT helicase G4273_RS10495 ENOG41072GX Peptidase M22 Glycoprotease G4273_RS10500 ENOG4105Y4Z Outer Membrane Lipoprotein G4273_RS10505 ENOG4105CEY Amp-dependent synthetase and ligase G4273_RS10510 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) G4273_RS10515 ENOG4105EJC lysr family transcriptional regulator G4273_RS10525 ENOG4108YS1 cytoplasmic protein G4273_RS10530 ENOG4105YP6 Domain of unknown function (DUF1869) G4273_RS10535 ENOG4105Y3U Transglycosylase-associated protein G4273_RS10545 ENOG4106G4W G4273_RS10550 ENOG410620I Diguanylate cyclase G4273_RS10555 ENOG4105UCG Domain of unknown function (DUF333) G4273_RS10560 ENOG4105K78 MarR family Transcriptional regulator G4273_RS10565 ENOG4105DJ2 Major Facilitator Superfamily G4273_RS10570 ENOG4105R1U AraC Family Transcriptional Regulator G4273_RS10585 ENOG4108KXH Ybak prolyl-tRNA synthetase associated G4273_RS10590 ENOG4108KHP Diguanylate cyclase G4273_RS10595 ENOG4106KTS Inner membrane protein yeaI G4273_RS10605 ENOG4105CYN Serine protein kinase G4273_RS10610 ENOG4105GNX MltA-interacting MipA family protein G4273_RS10615 ENOG4105CV8 reductase G4273_RS10620 ENOG4105DSB aldose 1-epimerase G4273_RS10625 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G4273_RS10635 ENOG4105VUT cytoplasmic protein G4273_RS10640 ENOG4105CPQ Dehydrogenase G4273_RS10645 ENOG4107TE1 transport protein G4273_RS10650 ENOG4105CPQ Dehydrogenase G4273_RS10655 ENOG4105D2N Aldolase G4273_RS10660 ENOG4107UH8 sugar kinase G4273_RS10665 ENOG4105CPC Aldo Keto reductase G4273_RS10670 ENOG4105E98 transcriptional regulator DeoR family G4273_RS10675 ENOG4108KUU Inner membrane metabolite transport protein ydjE G4273_RS10680 ENOG4108RWI nicotinamidase G4273_RS10685 ENOG4105HDK L-asparaginase G4273_RS10690 ENOG4105D07 Signal peptide peptidase, SppA G4273_RS10695 ENOG41069NU Nitroreductase G4273_RS10705 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G4273_RS10710 ENOG4105D82 Glutamate dehydrogenase G4273_RS10715 ENOG4105MTM Protein of unknown function (DUF1496) G4273_RS10725 ENOG4108T9J Cdp-alcohol phosphatidyltransferase G4273_RS10730 ENOG4107RM6 sulfurtransferase G4273_RS10735 ENOG4108VGW abc transporter atp-binding protein G4273_RS10740 ENOG4105CXZ ABC transporter, permease G4273_RS10745 ENOG4105VNH ABC transporter solute-binding protein G4273_RS10750 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G4273_RS10755 ENOG4108N5C SNARE associated Golgi protein-related protein G4273_RS10760 ENOG4108KCW iron-sulfur cluster binding G4273_RS10765 ENOG4108RSN SNARE associated Golgi G4273_RS10770 ENOG4105CGK Exodeoxyribonuclease III G4273_RS10800 ENOG4108SPG Periplasmic Protein G4273_RS10810 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) G4273_RS10820 ENOG4105KKI DNA-binding transcriptional activator OsmE G4273_RS10825 ENOG4105VZJ PTS System G4273_RS10830 ENOG4105CK1 PTS System G4273_RS10835 ENOG4105VCP PTS System G4273_RS10840 ENOG4105EZV Transcriptional regulator G4273_RS10845 ENOG4105F8D glycoside hydrolase family 4 G4273_RS10855 ENOG4105CH6 catalase G4273_RS10865 ENOG4108ETY sodium dicarboxylate symporter G4273_RS10870 ENOG4107K5X Membrane-bound metal-dependent hydrolase G4273_RS10875 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 G4273_RS10880 ENOG4107PN8 YfeABCD locus regulator G4273_RS10890 ENOG4105P10 Uncharacterized protein ydiZ G4273_RS10895 ENOG4105DE4 1-phosphofructokinase G4273_RS10900 ENOG4108NE3 Salt-induced outer membrane protein G4273_RS10920 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G4273_RS10925 ENOG41082NX 50s ribosomal protein l35 G4273_RS10960 ENOG4108V06 Glutathione peroxidase G4273_RS10970 ENOG4108QBX (LipO)protein G4273_RS10975 ENOG4108TC0 Diguanylate phosphodiesterase G4273_RS10990 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G4273_RS11000 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G4273_RS11005 ENOG4105CEY Amp-dependent synthetase and ligase G4273_RS11010 ENOG41090P5 ferredoxin-like protein G4273_RS11015 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G4273_RS11020 ENOG4105C10 Electron transfer flavoprotein G4273_RS11025 ENOG4105CV7 Electron transfer flavoprotein G4273_RS11030 ENOG4105W4W Transcriptional regulator G4273_RS11035 ENOG4105C1G acyl-Coa dehydrogenase G4273_RS11040 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G4273_RS11055 ENOG4105EMV Major Facilitator G4273_RS11060 ENOG4105EMV Major Facilitator G4273_RS11065 ENOG4105SUA Ydil protein G4273_RS11075 ENOG4105IPI Membrane G4273_RS11080 ENOG4105CQB FAD linked oxidase domain protein G4273_RS11085 ENOG4105KA0 thioesterase Superfamily protein G4273_RS11090 ENOG410671Z uncharacterized protein ydiH G4273_RS11095 ENOG4108Z4V iron-sulfur cluster assembly G4273_RS11100 ENOG4105DIW FeS assembly protein SUFB G4273_RS11105 ENOG4105C3K feS assembly ATPase SufC G4273_RS11110 ENOG4105JRK feS assembly protein SufD G4273_RS11125 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G4273_RS11130 ENOG4105KMX major outer membrane lipoprotein G4273_RS11135 ENOG4105CA9 Pyruvate kinase G4273_RS11140 ENOG4105RFR Protein of unknown function (DUF2767) G4273_RS11145 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein G4273_RS11150 ENOG4105WE2 aldehyde ferredoxin oxidoreductase G4273_RS11155 ENOG4105JVW G4273_RS11160 ENOG4108393 oxidoreductase Fe-S subunit G4273_RS11165 ENOG4108NWD Cytochrome G4273_RS11170 ENOG4108Y7C Conserved Protein G4273_RS11175 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain G4273_RS11180 ENOG4105N0V mono-oxygenase ydhR G4273_RS11205 ENOG4107QI1 Mate efflux family protein G4273_RS11210 ENOG4108R6K riboflavin synthase, subunit alpha G4273_RS11215 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G4273_RS11220 ENOG4105CZQ inner membrane transport protein YdhC G4273_RS11225 ENOG4105F52 Transcriptional regulator G4273_RS11240 ENOG4105F27 Major Facilitator G4273_RS11245 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4273_RS11250 ENOG4105K4H Nlp p60 protein G4273_RS11255 ENOG4105M2J Glutaredoxin G4273_RS11265 ENOG4108UYE Lactoylglutathione lyase G4273_RS11270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4273_RS11275 ENOG4108WUH Transcriptional regulator, TetR family G4273_RS11280 ENOG4105XZD Fe-S protein G4273_RS11285 ENOG4107RGM aldo keto reductase G4273_RS11290 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4273_RS11295 ENOG4105DSW Fusaric acid resistance protein G4273_RS11300 ENOG4105Y49 secretion protein, HlyD family G4273_RS11315 ENOG4108XTF Outer Membrane Lipoprotein G4273_RS11325 ENOG410642K Lysozyme inhibitor G4273_RS11340 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) G4273_RS11345 ENOG4108K3A Glutathione S-transferase G4273_RS11350 ENOG4105DUX Transporter G4273_RS11355 ENOG4105CSM endonuclease III G4273_RS11360 ENOG4105DZB Electron transport complex G4273_RS11365 ENOG4108UQQ Electron transport complex G4273_RS11390 ENOG4105M9B inner membrane protein ydgK G4273_RS11395 ENOG4105QZ5 OriC-binding nucleoid-associated protein G4273_RS11400 ENOG4106C6R beta-lactam resistance protein G4273_RS11405 ENOG4105D9R oxidoreductase G4273_RS11415 ENOG4105C87 Aminotransferase class I and II G4273_RS11420 ENOG4105CI1 PTS System G4273_RS11425 ENOG4107P2S Transcriptional regulator G4273_RS11430 ENOG4107ZQV short-chain dehydrogenase reductase G4273_RS11435 ENOG4105XEA Tetr family transcriptional regulator G4273_RS11440 ENOG4105CNT hydrolase family 2 G4273_RS11445 ENOG4105CT4 transporter G4273_RS11450 ENOG4108QNI outer membrane porin protein G4273_RS11455 ENOG4106J39 exported protein G4273_RS11460 ENOG4105EIP mannose-6-phosphate isomerase G4273_RS11465 ENOG4107GFK fumarate G4273_RS11470 ENOG4105C9Q fumarate hydratase class II G4273_RS11480 ENOG4105JJR Histidine kinase G4273_RS11485 ENOG4107EXC regulatoR G4273_RS11490 ENOG4105RA2 Membrane G4273_RS11495 ENOG410642E Short chain dehydrogenase G4273_RS11500 ENOG4105D5Q Arginine ornithine antiporter G4273_RS11505 ENOG4105C5D exported protein G4273_RS11510 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G4273_RS11515 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G4273_RS11520 ENOG4105DSF transport protein G4273_RS11535 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap G4273_RS11550 ENOG4105D94 Major Facilitator Superfamily G4273_RS11555 ENOG4106NZI LysR family Transcriptional regulator G4273_RS11560 ENOG4105DAG ROK family G4273_RS11565 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G4273_RS11575 ENOG4108NEM leader-binding protein dmsD G4273_RS11580 ENOG4107KGK dmso reductase anchor subunit G4273_RS11585 ENOG4105QAX Iron-sulfur G4273_RS11590 ENOG4105C3J Cysteine desulfurase G4273_RS11595 ENOG4107QY8 reductase G4273_RS11600 ENOG4105KBG Protein of unknown function (DUF1161) G4273_RS11610 ENOG4108MK9 spermidine N(1)-acetyltransferase G4273_RS11625 ENOG4105CXK mandelate racemase muconate lactonizing G4273_RS11630 ENOG4105CPQ Dehydrogenase G4273_RS11640 ENOG4105DEI Mannitol dehydrogenase G4273_RS11645 ENOG41061EV selenium-binding protein YdfZ G4273_RS11650 ENOG4107XBN GntR Family Transcriptional Regulator G4273_RS11655 ENOG4105EMU Dehydrogenase G4273_RS11660 ENOG4105DGW oligopeptidase A G4273_RS11665 ENOG4108YDI single-species biofilm formation on inanimate substrate G4273_RS11670 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria G4273_RS11680 ENOG4105E5W Transporter G4273_RS11685 ENOG4108594 Permease of the drug metabolite transporter G4273_RS11690 ENOG4105FDP GntR family transcriptional regulator G4273_RS11700 ENOG4105CK1 PTS System G4273_RS11705 ENOG4105VCP PTS System G4273_RS11715 ENOG4105CS2 ec 3.2.1.21 G4273_RS11720 ENOG4106DNR multiple antibiotic resistance protein G4273_RS11725 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF G4273_RS11730 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G4273_RS11750 ENOG4105EGI Transcriptional regulator G4273_RS11755 ENOG4105C26 Dehydrogenase G4273_RS11760 ENOG4105CSV Glutaminase G4273_RS11765 ENOG4105M0C cytoplasmic protein G4273_RS11775 ENOG4105BZU Histidine kinase G4273_RS11785 ENOG4105FFC UPF0187 protein G4273_RS11795 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein G4273_RS11800 ENOG4105CAF HipA N-terminal domain protein G4273_RS11825 ENOG4105EQ2 LysR family Transcriptional regulator G4273_RS11830 ENOG4105CGD Nad-dependent epimerase dehydratase G4273_RS11835 ENOG4108RQP Major type 1 subunit fimbrin G4273_RS11845 ENOG4105CW0 outer membrane usher protein G4273_RS11850 ENOG4108WDE Fimbrial protein G4273_RS11855 ENOG4106318 fimbrial-like protein YdeR G4273_RS11860 ENOG4106PIH fimbrial-like protein ydeQ G4273_RS11865 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit G4273_RS11875 ENOG4108NKV transcriptional regulator G4273_RS11880 ENOG4105ENH Sulfatase G4273_RS11885 ENOG4105C4X radical SAM domain protein G4273_RS11900 ENOG4105CVK Glutamate decarboxylase G4273_RS11905 ENOG4105E5D amino acid G4273_RS11910 ENOG4105F32 YngK protein G4273_RS11925 ENOG4108Z9K Osmotically inducible protein G4273_RS11930 ENOG4105TPS biofilm-dependent modulation protein G4273_RS11935 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein G4273_RS11945 ENOG4105DQ4 alcohol dehydrogenase G4273_RS11955 ENOG41084S7 Plasmid maintenance system antidote protein G4273_RS11960 ENOG4108MG3 formate dehydrogenase G4273_RS11965 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G4273_RS11975 ENOG4105RPH Inner membrane protein YddG G4273_RS11980 ENOG4107QND Nitrite extrusion protein G4273_RS11985 ENOG4105CRU nitrate reductase, alpha subunit G4273_RS11990 ENOG4108IUE nitrate reductase beta subunit G4273_RS11995 ENOG4108NZN Respiratory nitrate reductase 2 delta chain G4273_RS12000 ENOG4105D0D Nitrate reductase 2, gamma subunit G4273_RS12005 ENOG4105JAB phenazine biosynthesis protein, phzf family G4273_RS12010 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G4273_RS12020 ENOG4105CS6 Rhs element vgr protein G4273_RS12030 ENOG4108N27 Glutathione S-transferase G4273_RS12035 ENOG4108N27 Glutathione S-transferase G4273_RS12040 ENOG4105C85 amino acid G4273_RS12045 ENOG4108NS2 receptor G4273_RS12060 ENOG4108Z7F N-acetyltransferase G4273_RS12065 ENOG4108T9Y Inner membrane protein ydcZ G4273_RS12070 ENOG4105R71 cytoplasmic protein G4273_RS12075 ENOG410654E Membrane G4273_RS12090 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component G4273_RS12095 ENOG4105D81 ABC transporter, permease G4273_RS12100 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G4273_RS12105 ENOG4107TYH extracellular solute-binding protein family 1 G4273_RS12110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4273_RS12120 ENOG4105RR0 Protein of unknown function (DUF2554) G4273_RS12125 ENOG4105CFP Peptidase U32 G4273_RS12130 ENOG4108JCI Transcriptional regulator G4273_RS12135 ENOG4105DKK Benzoate G4273_RS12140 ENOG4108KKZ (LipO)protein G4273_RS12145 ENOG41088CC tellurite resistance protein tehB G4273_RS12150 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein G4273_RS12155 ENOG4107WE3 acetyltransferase YdcK G4273_RS12160 ENOG4108Z9I -acetyltransferase G4273_RS12165 ENOG4105Z2P Protein of unknown function (DUF465) G4273_RS12175 ENOG4105E32 cytoplasmic protein G4273_RS12180 ENOG4105DDW LysR family Transcriptional regulator G4273_RS12190 ENOG4107NK6 Hok/gef family G4273_RS12195 ENOG4105UPP uncharacterized protein ydcA G4273_RS12200 ENOG4105CPW cytochrome b561 G4273_RS12205 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G4273_RS12210 ENOG4105C26 Dehydrogenase G4273_RS12215 ENOG4107DB1 DUF218 domain G4273_RS12220 ENOG4105CQ7 ATP-dependent helicase G4273_RS12230 ENOG41077RS Phosphatase G4273_RS12235 ENOG4105E8V Alpha Beta Hydrolase Fold protein G4273_RS12240 ENOG4108HPI phosphatidate Cytidylyltransferase G4273_RS12250 ENOG4107S5I aldo keto reductase G4273_RS12255 ENOG4107EF2 surface-exposed virulence protein G4273_RS12260 ENOG4105WXT Conserved Protein G4273_RS12265 ENOG410689M (LipO)protein G4273_RS12270 ENOG4107H52 Dicarboxylate transport G4273_RS12275 ENOG4105C5I Dehydrogenase G4273_RS12280 ENOG41090X5 Heat shock protein hslJ G4273_RS12285 ENOG4105IKK cytoplasmic protein G4273_RS12290 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) G4273_RS12295 ENOG4105FCK Membrane G4273_RS12300 ENOG4108RW8 Universal stress protein F G4273_RS12325 ENOG4105C1J atp-dependent rna helicase G4273_RS12335 ENOG4105BZU Histidine kinase G4273_RS12340 ENOG4108DG9 Smr protein MutS2 G4273_RS12355 ENOG4105R1U AraC Family Transcriptional Regulator G4273_RS12365 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G4273_RS12370 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G4273_RS12375 ENOG4105Q9Y Universal stress protein G4273_RS12380 ENOG4105S5I Membrane G4273_RS12385 ENOG4105D64 Mechanosensitive ion channel G4273_RS12390 ENOG4107QSI ABC, transporter G4273_RS12395 ENOG4105EQ2 LysR family Transcriptional regulator G4273_RS12400 ENOG4105ENX hydrolase G4273_RS12415 ENOG4105KXI murein peptide amidase A G4273_RS12420 ENOG4107S8C mandelate racemase muconate lactonizing G4273_RS12425 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) G4273_RS12430 ENOG4108JU8 Transcriptional regulator G4273_RS12440 ENOG4105CM6 amino acid regulated cytosolic protein G4273_RS12445 ENOG4105FKQ transcriptional regulator G4273_RS12450 ENOG4107EFV Outer membrane protein G G4273_RS12460 ENOG4107URF beta-phospho-glucomutase G4273_RS12465 ENOG4105C71 hydrolase family 65, central catalytic G4273_RS12470 ENOG4105CK5 oxidoreductase G4273_RS12475 ENOG4107TYA transient receptor potential locus G4273_RS12480 ENOG4107RRD Dehydrogenase G4273_RS12485 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G4273_RS12490 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component G4273_RS12495 ENOG4105WEM extracellular solute-binding protein G4273_RS12500 ENOG4107QW3 Sucrose phosphorylase G4273_RS12505 ENOG4105K8Z Phage shock protein G4273_RS12510 ENOG4105NNG Peripheral inner membrane phage-shock protein G4273_RS12515 ENOG4105FM1 phage shock protein C G4273_RS12520 ENOG4105YYT phage shock protein B G4273_RS12525 ENOG41087YS Phage shock protein A G4273_RS12530 ENOG4105E51 psp operon transcriptional activator G4273_RS12540 ENOG4105N0E Protein of unknown function (DUF2543) G4273_RS12545 ENOG4108HIY periplasmic G4273_RS12550 ENOG4108I5W peptide transport system, permease protein G4273_RS12555 ENOG4108EU3 peptide transport system, permease G4273_RS12560 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein G4273_RS12565 ENOG4108JQ2 peptide transport system atp-binding protein G4273_RS12570 ENOG4105C2C drug resistance transporter, Bcr CflA G4273_RS12575 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G4273_RS12580 ENOG4105BZS acriflavin resistance protein G4273_RS12585 ENOG4105C1P efflux transporter, rnd family, mfp subunit G4273_RS12590 ENOG41067SE Tetr family transcriptional regulator G4273_RS12595 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G4273_RS12600 ENOG4105Q4T oxidoreductase G4273_RS12615 ENOG4105BZU Histidine kinase G4273_RS12620 ENOG410643D UPF0509 protein G4273_RS12625 ENOG4105N2W Transcriptional regulator G4273_RS12635 ENOG4108ZJT translation initiation factor, Sui1 G4273_RS12645 ENOG4105CFV Tetratricopeptide repeat protein G4273_RS12650 ENOG4105Q4A inner membrane protein yciS G4273_RS12655 ENOG4105EYK Phosphatidylglycerophosphatase B G4273_RS12665 ENOG4107QM5 aconitate hydratase G4273_RS12685 ENOG4107R11 Transcriptional regulator G4273_RS12690 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G4273_RS12695 ENOG4105RKX Protein of unknown function (DUF2498) G4273_RS12700 ENOG4105ERU peptidase G4273_RS12705 ENOG4105UBK short-chain dehydrogenase reductase G4273_RS12710 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G4273_RS12715 ENOG4105FE9 pseudouridine synthase G4273_RS12720 ENOG4105EG3 transmembrane signal peptide protein G4273_RS12725 ENOG4107RTD sua5 ycio yrdc ywlc family protein G4273_RS12730 ENOG4105DB7 PHP domain protein G4273_RS12740 ENOG4105CRQ synthase (Component I) G4273_RS12745 ENOG4108EFP Anthranilate synthase component II G4273_RS12750 ENOG4105DK0 Indole-3-glycerol phosphate synthase G4273_RS12765 ENOG4108Z9Z response to DNA damage stimulus G4273_RS12770 ENOG4108N8X transition metal ion binding G4273_RS12775 ENOG4105EIF outer membrane protein W G4273_RS12795 ENOG4105NAU thioesterase Superfamily protein G4273_RS12800 ENOG410822N TonB family G4273_RS12805 ENOG4105K9H YciI-like protein G4273_RS12810 ENOG4107SVH Potassium channel protein G4273_RS12830 ENOG4108JQ7 (ABC) transporter G4273_RS12835 ENOG4105C3U ABC transporter G4273_RS12840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4273_RS12845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4273_RS12850 ENOG4108J59 Extracellular solute-binding protein, family 5 G4273_RS12855 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G4273_RS12860 ENOG4105C0A alcohol dehydrogenase G4273_RS12870 ENOG4107104 thymidine kinase G4273_RS12875 ENOG4108SAU DNA-binding protein H-ns G4273_RS12880 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G4273_RS12885 ENOG4105I93 response regulator G4273_RS12890 ENOG4105D78 K07001 NTE family protein G4273_RS12900 ENOG4105CIY formyltetrahydrofolate deformylase G4273_RS12925 ENOG41076YT nitrate reductase, gamma subunit G4273_RS12930 ENOG4105R3A Nitrate reductase G4273_RS12935 ENOG4108IUE nitrate reductase beta subunit G4273_RS12940 ENOG4105CRU nitrate reductase, alpha subunit G4273_RS12945 ENOG4105DQQ Major facilitator superfamily MFS_1 G4273_RS12950 ENOG4105BZU Histidine kinase G4273_RS12955 ENOG4105WH1 Two component transcriptional regulator luxr family G4273_RS12960 ENOG4105ID0 Putative invasin G4273_RS12965 ENOG41090EX DsrE family G4273_RS12970 ENOG4108NH8 Cation transport protein G4273_RS12975 ENOG4105WS7 Cation transport regulator G4273_RS12980 ENOG4105EWV Sodium calcium exchanger membrane region G4273_RS12995 ENOG41063JG Transcriptional regulator G4273_RS13000 ENOG4108YY7 Invasion gene expression up-regulator SirB G4273_RS13005 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G4273_RS13020 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) G4273_RS13030 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G4273_RS13035 ENOG4105CHH sulfate transporter G4273_RS13040 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria G4273_RS13050 ENOG4105C3G gtp-binding protein G4273_RS13060 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family G4273_RS13065 ENOG4105CMT Dihydroxyacetone kinase G4273_RS13070 ENOG4108UTZ Dihydroxyacetone kinase G4273_RS13075 ENOG4105VDH Dihydroxyacetone kinase G4273_RS13080 ENOG4105E53 ec 3.2.1.28 G4273_RS13085 ENOG4105S10 periplasmic binding protein G4273_RS13090 ENOG4105EHG Permease protein G4273_RS13095 ENOG4105E0A ABC, transporter G4273_RS13100 ENOG4108BSC Methyltransferase G4273_RS13105 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G4273_RS13120 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) G4273_RS13130 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G4273_RS13140 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G4273_RS13150 ENOG4105ED1 spovr family G4273_RS13165 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) G4273_RS13170 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G4273_RS13175 ENOG4105KT5 UmuD protein G4273_RS13185 ENOG4108ZZ3 UPF0260 protein G4273_RS13190 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G4273_RS13200 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium G4273_RS13205 ENOG4105S66 prophage protein G4273_RS13215 ENOG4107QMS site-determining protein G4273_RS13250 ENOG410658X G4273_RS13275 ENOG410738I uncharacterized protein ymgC G4273_RS13285 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB G4273_RS13290 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component G4273_RS13295 ENOG4105BZU Histidine kinase G4273_RS13300 ENOG4108XDN Transcriptional regulator G4273_RS13305 ENOG41064WM Uncharacterized protein YcgX G4273_RS13315 ENOG4108HMX isocitrate dehydrogenase (NADP) G4273_RS13330 ENOG4105DIK (ABC) transporter G4273_RS13335 ENOG4105CC5 ABC transporter G4273_RS13340 ENOG4105CC5 ABC transporter G4273_RS13355 ENOG4108X9F tail fiber protein G4273_RS13425 ENOG4105IM0 capsid protein G4273_RS13450 ENOG4105UZW Tail fiber assembly protein G4273_RS13470 ENOG4105QYK bacteriophage lambda Bor protein homolog G4273_RS13480 ENOG4105KUS lysozyme G4273_RS13485 ENOG4105QFS Lysis protein S homolog from lambdoid prophage G4273_RS13495 ENOG4105HRS Antitermination protein G4273_RS13530 ENOG4105NY2 NinB protein G4273_RS13685 ENOG4108I1J Integrase G4273_RS13690 ENOG4108HMX isocitrate dehydrogenase (NADP) G4273_RS13715 ENOG4107QTF adenylosuccinate lyase G4273_RS13720 ENOG4105XJC Two component transcriptional regulator (Winged helix family G4273_RS13725 ENOG4105IFJ Histidine kinase G4273_RS13730 ENOG4105EZE Cupin 4 family protein G4273_RS13740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G4273_RS13750 ENOG4105D38 putrescine abc transporter G4273_RS13755 ENOG4107RUE extracellular solute-binding protein family 1 G4273_RS13770 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G4273_RS13780 ENOG4105D60 lipoprotein releasing system transmembrane protein G4273_RS13785 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G4273_RS13790 ENOG4105D60 lipoprotein releasing system transmembrane protein G4273_RS13795 ENOG4105IQC Inner membrane protein YcfT G4273_RS13800 ENOG4108JA2 transcriptioN-repair coupling factor G4273_RS13805 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G4273_RS13810 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction G4273_RS13815 ENOG4108IND Tetr family transcriptional regulator G4273_RS13820 ENOG4107MBR 17 kDa surface antigen G4273_RS13825 ENOG4105CEP NADH dehydrogenase G4273_RS13845 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) G4273_RS13850 ENOG41090DQ Lipoprotein G4273_RS13855 ENOG4105K59 histidine triad (HIT) protein G4273_RS13860 ENOG4105CNM Receptor G4273_RS13865 ENOG4105CI1 PTS System G4273_RS13870 ENOG4105F8V Hydrolase, tatD family G4273_RS13875 ENOG4107QRG dna polymerase iii G4273_RS13885 ENOG4105HHA aminodeoxychorismate lyase G4273_RS13890 ENOG4105YAZ 4-amino-4-deoxychorismate lyase G4273_RS13895 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G4273_RS13900 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G4273_RS13905 ENOG4105CHR reductase G4273_RS13910 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G4273_RS13930 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G4273_RS13935 ENOG4108UHJ MAF-like protein G4273_RS13940 ENOG4105EI2 Pseudouridine synthase G4273_RS13945 ENOG4107QQB Ribonuclease E G4273_RS13950 ENOG4105DTJ flagellar hook-associated protein G4273_RS13955 ENOG4105E1Q flagellar hook-associated protein G4273_RS13960 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj G4273_RS13975 ENOG4105CGA flagellar basal-body rod protein FlgG G4273_RS13980 ENOG4108KPB Flagellar basal-body rod protein FlgF G4273_RS13985 ENOG4105BZE flagellar hook protein, FlgE G4273_RS13990 ENOG4105W00 Flagellar hook capping protein G4273_RS13995 ENOG4108ZC9 flagellar basal-body rod protein flgc G4273_RS14000 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) G4273_RS14005 ENOG4105CKS Flagella basal body P-ring formation protein flgA G4273_RS14010 ENOG4105M9M anti-sigma28 factor FlgM G4273_RS14015 ENOG4105QVD Flagella synthesis protein FlgN G4273_RS14020 ENOG4105CJR Integral membrane protein (MviN G4273_RS14025 ENOG4105EP9 oxidoreductase G4273_RS14035 ENOG4105D9U N-acetyltransferase G4273_RS14045 ENOG4105E9S glutaredoxin 2 G4273_RS14050 ENOG4105F3T (LipO)protein G4273_RS14055 ENOG4105EKE dihydroorotase G4273_RS14060 ENOG4105MEA DNA damage-inducible protein i G4273_RS14065 ENOG4105PVA Biofilm formation regulatory protein BssS G4273_RS14070 ENOG4105F76 Sarcosine oxidase G4273_RS14075 ENOG4106974 biofilm formation G4273_RS14080 ENOG4105DS1 cytochrome b561 G4273_RS14085 ENOG4108YYC ycei family G4273_RS14095 ENOG4105D1S lipid A biosynthesis G4273_RS14100 ENOG4105C6X Major Facilitator G4273_RS14105 ENOG4108W47 Acidic protein msyB G4273_RS14110 ENOG4105NAC (LipO)protein G4273_RS14115 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) G4273_RS14130 ENOG4107RZC phospholipase d G4273_RS14135 ENOG4108UVJ appr-1-p processing domain protein G4273_RS14150 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin G4273_RS14155 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers G4273_RS14160 ENOG41086KC Transcriptional regulator G4273_RS14165 ENOG4108XDW curli assembly protein CsgE G4273_RS14170 ENOG4108WYR Curli production assembly transport component, CsgF G4273_RS14175 ENOG4105P8Q Curli production assembly transport component CsgG G4273_RS14180 ENOG4108UQ5 membrane protein YcdZ G4273_RS14185 ENOG4107XHZ cytoplasmic chaperone TorD family protein G4273_RS14205 ENOG4105BZU Histidine kinase G4273_RS14210 ENOG4108TUY outer membrane protein PgaA G4273_RS14215 ENOG4107BJW polysaccharide deacetylase G4273_RS14220 ENOG4105CND Glycosyl transferase, family 2 G4273_RS14230 ENOG4105D5M phosphate starvation-inducible protein G4273_RS14235 ENOG4105DBE peroxidase G4273_RS14245 ENOG4105EKT )-iron permease G4273_RS14250 ENOG4105CK7 Sodium proline symporter G4273_RS14260 ENOG4105C26 Dehydrogenase G4273_RS14265 ENOG4108R86 Transcriptional regulator G4273_RS14275 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G4273_RS14295 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) G4273_RS14300 ENOG4105C2W permease G4273_RS14305 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 G4273_RS14315 ENOG4105XH3 G4273_RS14320 ENOG4105D6F Phosphatase G4273_RS14335 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) G4273_RS14340 ENOG4108EM1 reductase G4273_RS14345 ENOG4105CUW cytochrome C-TYPE protein G4273_RS14350 ENOG4106WF9 DNA-binding transcriptional regulator TorR G4273_RS14355 ENOG4108SV3 Tmao reductase system periplasmic protein tort G4273_RS14360 ENOG4105BZU Histidine kinase G4273_RS14365 ENOG4105HEE Binding Domain protein G4273_RS14370 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation G4273_RS14385 ENOG4105VEQ Cold shock protein G4273_RS14390 ENOG41060EU Cold shock-like protein G4273_RS14395 ENOG4105D6F Phosphatase G4273_RS14405 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G4273_RS14410 ENOG4105C4M (Ubiquinol oxidase) subunit I G4273_RS14415 ENOG4105MVP hydrogenase-1 operon protein HyaF G4273_RS14420 ENOG4108VXY Hydrogenase-1 operon protein HyaE G4273_RS14425 ENOG4108USZ hydrogenase G4273_RS14430 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit G4273_RS14435 ENOG4105DPX Hydrogenase, large subunit G4273_RS14440 ENOG4105E3S small subunit G4273_RS14450 ENOG4108MN8 Membrane G4273_RS14455 ENOG4108Z0T Part of a sulfur-relay system (By similarity) G4273_RS14475 ENOG4105K4P CoA-binding domain protein G4273_RS14490 ENOG41088T4 Helicase IV G4273_RS14495 ENOG410901E Membrane G4273_RS14500 ENOG4105EM2 membrane G4273_RS14505 ENOG4108RZ1 DNA transformation protein G4273_RS14515 ENOG4105UYK outer membrane protein a G4273_RS14525 ENOG4105DAN ATP-dependent protease G4273_RS14535 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) G4273_RS14540 ENOG4108Q2G (LipO)protein G4273_RS14545 ENOG4105DY2 Paraquat-inducible protein b G4273_RS14550 ENOG4105F1S paraquat-inducible protein a G4273_RS14555 ENOG4105C5H ABC transporter G4273_RS14560 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G4273_RS14565 ENOG4105QVC MOSC domain-containing protein G4273_RS14570 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) G4273_RS14580 ENOG4108UZX fmn reductase G4273_RS14585 ENOG4105GVF (ABC) transporter G4273_RS14595 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G4273_RS14605 ENOG4105CD8 aminopeptidase N G4273_RS14625 ENOG4105CGF Aromatic amino acid aminotransferase G4273_RS14630 ENOG4105C5X domain protein G4273_RS14635 ENOG4105EAQ (twin-arginine translocation) pathway signal G4273_RS14645 ENOG4105DIT ErfK YbiS YcfS YnhG family protein G4273_RS14655 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) G4273_RS14665 ENOG4106371 Methyltransferase G4273_RS14670 ENOG4107S90 membrAne G4273_RS14675 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups G4273_RS14690 ENOG4105T0Z Conserved Protein G4273_RS14700 ENOG4105BZ1 (ABC) transporter G4273_RS14705 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 G4273_RS14715 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G4273_RS14725 ENOG4108K0D peptidase, M48 G4273_RS14740 ENOG4107VMU Membrane G4273_RS14745 ENOG4105DDY UPF0142 protein ycaO G4273_RS14750 ENOG4105TMB Formate nitrite transporter G4273_RS14755 ENOG4105C6N Formate acetyltransferase G4273_RS14760 ENOG4105F1A Pyruvate formate-lyase G4273_RS14770 ENOG4105CHJ isochorismatase hydrolase G4273_RS14775 ENOG4107KGK dmso reductase anchor subunit G4273_RS14780 ENOG4105QAX Iron-sulfur G4273_RS14785 ENOG4107QY8 reductase G4273_RS14795 ENOG4105D1H recombination factor protein RarA G4273_RS14805 ENOG4105CNU cell division protein FtsK G4273_RS14815 ENOG4105C3M thioredoxin reductase G4273_RS14820 ENOG4108JJ9 ABC, transporter G4273_RS14825 ENOG4108JJ8 (ABC) transporter G4273_RS14835 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G4273_RS14845 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G4273_RS14855 ENOG4105VEQ Cold shock protein G4273_RS14865 ENOG4105DJY efflux transporter, rnd family, mfp subunit G4273_RS14870 ENOG4108MJ5 VirK protein G4273_RS14875 ENOG4105CPB ATP-dependent endonuclease of the OLD family G4273_RS14880 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G4273_RS14885 ENOG4105DWU Membrane G4273_RS14890 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) G4273_RS14895 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G4273_RS14900 ENOG4105C7K acetolactate synthase G4273_RS14905 ENOG4105C5W Aldolase G4273_RS14910 ENOG4105CGD Nad-dependent epimerase dehydratase G4273_RS14915 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase G4273_RS14920 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G4273_RS14930 ENOG41064MM (LipO)protein G4273_RS14935 ENOG4105E5Z arginine transporter ATP-binding subunit G4273_RS14940 ENOG4106PMH Extracellular solute-binding protein family 3 G4273_RS14945 ENOG4105GBT ABC transporter G4273_RS14950 ENOG4105DMR ABC, transporter G4273_RS14955 ENOG4106TNF Periplasmic binding protein G4273_RS14965 ENOG4105RBQ inner membrane protein ybjO G4273_RS14970 ENOG4105D38 putrescine abc transporter G4273_RS14975 ENOG4105F38 ABC transporter, permease G4273_RS14980 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G4273_RS14985 ENOG4107RUE extracellular solute-binding protein family 1 G4273_RS14990 ENOG4108RMJ sensory transduction regulator G4273_RS15000 ENOG4108DBC nitroreductase G4273_RS15005 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress G4273_RS15010 ENOG41090BQ Glutaredoxin G4273_RS15015 ENOG4105GWF inner membrane protein YbjM G4273_RS15025 ENOG4108RFG Tetr family transcriptional regulator G4273_RS15030 ENOG4106UW1 Major Facilitator superfamily G4273_RS15035 ENOG4108HCJ Hydrolase G4273_RS15045 ENOG4107QF7 multi-drug G4273_RS15050 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G4273_RS15055 ENOG4107FB0 transcriptional regulator DeoR family G4273_RS15060 ENOG4105DZ1 carboxypeptidase G4273_RS15065 ENOG4108TGY Glutathione S-transferase G4273_RS15070 ENOG4105D8V Glucose sorbosone dehydrogenase G4273_RS15075 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway G4273_RS15090 ENOG4105BZU Histidine kinase G4273_RS15115 ENOG4105D44 asparaginase G4273_RS15120 ENOG4105CVM Molybdenum cofactor synthesis domain protein G4273_RS15125 ENOG4105D06 uba thif-type nad fad binding protein G4273_RS15130 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G4273_RS15135 ENOG4105F1A Pyruvate formate-lyase G4273_RS15145 ENOG4108HCJ Hydrolase G4273_RS15150 ENOG4105C5H ABC transporter G4273_RS15155 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G4273_RS15160 ENOG4105F4P )-transporter G4273_RS15165 ENOG4105KST dependent repressor G4273_RS15175 ENOG4108I6E Sulfatase G4273_RS15180 ENOG4108T1M outer membrane protein x G4273_RS15190 ENOG4107AQZ Membrane G4273_RS15200 ENOG4107R0W ABC transporter G4273_RS15205 ENOG4105E5Q amino acid AbC transporter G4273_RS15210 ENOG4105CDA abc transporter atp-binding protein G4273_RS15215 ENOG4105D8X mechanosensitive ion channel G4273_RS15225 ENOG4105ZY9 UPF0379 protein ybiM G4273_RS15240 ENOG4105KSC Transcriptional regulator, TraR DksA family G4273_RS15245 ENOG4105VR4 UPF0379 protein ybiJ G4273_RS15250 ENOG4105DG4 malate L-lactate dehydrogenase G4273_RS15255 ENOG4108MTB glycosyl transferase family G4273_RS15260 ENOG4105DVT helicase G4273_RS15270 ENOG4105C1J atp-dependent rna helicase G4273_RS15275 ENOG4107MVR Transcriptional regulator G4273_RS15280 ENOG4105D0S secretion protein (HlyD G4273_RS15285 ENOG4105CJ1 ABC, transporter G4273_RS15290 ENOG4107QWP ABC-2 type transporter G4273_RS15295 ENOG4107QWP ABC-2 type transporter G4273_RS15300 ENOG4105I9U inner membrane protein ybhQ G4273_RS15305 ENOG4105X23 Endonuclease Exonuclease phosphatase G4273_RS15310 ENOG4105DZQ phospholipase D Transphosphatidylase G4273_RS15315 ENOG4107UXM Membrane G4273_RS15320 ENOG410733J conserved inner membrane protein G4273_RS15325 ENOG4105HFZ Membrane G4273_RS15330 ENOG4108ZAF Molybdopterin G4273_RS15335 ENOG4105M00 molybdopterin converting factor, subunit 1 G4273_RS15345 ENOG4108RIR Molybdenum cofactor biosynthesis protein G4273_RS15355 ENOG4105CHW UPF0052 protein G4273_RS15365 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G4273_RS15370 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G4273_RS15375 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4273_RS15385 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G4273_RS15390 ENOG4105D7V transposase G4273_RS15395 ENOG4108V1U phospholipid-binding protein G4273_RS15400 ENOG4105NBR Pectinesterase G4273_RS15405 ENOG4107QM5 aconitate hydratase G4273_RS15410 ENOG4107QPK )-transporter G4273_RS15415 ENOG4105C7F AcnD-accessory protein PrpF G4273_RS15420 ENOG4105F04 LysR family Transcriptional regulator G4273_RS15430 ENOG4108K4B hydrolase G4273_RS15435 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G4273_RS15440 ENOG4105E0C molybdate abc transporter G4273_RS15445 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G4273_RS15455 ENOG4105F4R Transcriptional regulator mode G4273_RS15460 ENOG4105DKW ABC transporter G4273_RS15465 ENOG4105CMR udp-glucose 4-epimerase G4273_RS15470 ENOG4105F0Z galactose-1-phosphate uridylyltransferase G4273_RS15480 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G4273_RS15490 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G4273_RS15495 ENOG4105JND homeobox protein G4273_RS15500 ENOG4105PGM cation diffusion facilitator family transporter G4273_RS15505 ENOG4106Z1T Nicotinamide Mononucleotide Transporter G4273_RS15510 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G4273_RS15550 ENOG4105UFD tol-pal system protein YbgF G4273_RS15555 ENOG4105KCK Peptidoglycan-associated lipoprotein G4273_RS15565 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA G4273_RS15575 ENOG4105E02 MotA TolQ exbB proton channel G4273_RS15580 ENOG4107YD3 Thioesterase G4273_RS15585 ENOG4105KJB cyd operon protein YbgE G4273_RS15595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G4273_RS15600 ENOG4105C4M (Ubiquinol oxidase) subunit I G4273_RS15610 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G4273_RS15620 ENOG4105C7S Dehydrogenase G4273_RS15625 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G4273_RS15630 ENOG4105E33 succinate dehydrogenase G4273_RS15635 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G4273_RS15640 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein G4273_RS15645 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit G4273_RS15655 ENOG4105BZN citrate synthase G4273_RS15665 ENOG4108KK1 membrane protein AbrB duplication G4273_RS15670 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) G4273_RS15675 ENOG4105E7W lamb ycsf family protein G4273_RS15680 ENOG4107R7A Allophanate hydrolase subunit 2 G4273_RS15685 ENOG4105P4J Allophanate hydrolase, subunit 1 G4273_RS15690 ENOG4107QNR UPF0135 protein G4273_RS15695 ENOG4105DUX Transporter G4273_RS15700 ENOG4105CVP deoxyribo-dipyrimidine photolyase G4273_RS15705 ENOG4107SEY Conserved Protein G4273_RS15710 ENOG4105XIQ Protein of unknown function (DUF2517) G4273_RS15730 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G4273_RS15735 ENOG4105C08 Histidine kinase G4273_RS15740 ENOG4105EEX Two component transcriptional regulator (Winged helix family G4273_RS15750 ENOG4105CXN decarboxylase G4273_RS15755 ENOG4105D5Q Arginine ornithine antiporter G4273_RS15760 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 G4273_RS15765 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) G4273_RS15770 ENOG4105EV9 Alpha Beta Hydrolase G4273_RS15775 ENOG4105NNH LexA regulated protein G4273_RS15780 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) G4273_RS15790 ENOG41090R7 Ferric uptake G4273_RS15795 ENOG4105GX6 (LipO)protein G4273_RS15810 ENOG4105MVE transcriptional regulator G4273_RS15815 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G4273_RS15820 ENOG4107S2N Type III effector Hrp-dependent G4273_RS15825 ENOG4108JB8 alcohol dehydrogenase G4273_RS15830 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G4273_RS15835 ENOG4105EE5 Membrane protein terC G4273_RS15855 ENOG4108C33 Resolvase G4273_RS15975 ENOG4108QUU Morphogenesis Protein G4273_RS15985 ENOG4105CF2 Mu-like prophage FluMu protein GP28 G4273_RS16110 ENOG4105ZIA Phage protein gp16 G4273_RS16120 ENOG4105CI1 PTS System G4273_RS16130 ENOG4105CE4 GlcNAc 6-P deacetylase G4273_RS16135 ENOG4105E2R ROK family G4273_RS16140 ENOG4105D4U had-superfamily hydrolase, subfamily iia G4273_RS16145 ENOG4105CAQ asparagine synthetase G4273_RS16185 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G4273_RS16195 ENOG4105C9A Phoh family G4273_RS16205 ENOG4108JU5 Magnesium and cobalt efflux protein G4273_RS16210 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G4273_RS16215 ENOG4107U91 Rhomboid family G4273_RS16220 ENOG4107RP9 extracellular solute-binding protein, family 3 G4273_RS16225 ENOG4105EAD ABC transporter G4273_RS16230 ENOG4105DRP amino acid AbC transporter G4273_RS16235 ENOG4105CDA abc transporter atp-binding protein G4273_RS16245 ENOG4107PAI alpha helical protein G4273_RS16260 ENOG4105DJF DNA polymerase III, delta' subunit G4273_RS16270 ENOG4108TGR phosphatase G4273_RS16275 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G4273_RS16285 ENOG4105CJN penicillin-binding protein G4273_RS16290 ENOG4105CNI cell division protein FtsW G4273_RS16295 ENOG4105K6T rare lipoprotein A G4273_RS16325 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) G4273_RS16345 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) G4273_RS16350 ENOG4105CEE C4-dicarboxylate transporter G4273_RS16355 ENOG4106YYS transcriptional regulatory protein G4273_RS16360 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G4273_RS16365 ENOG4105DUA (citrate (pro-3S)-lyase ligase G4273_RS16375 ENOG4105CI0 Citrate lyase G4273_RS16380 ENOG4105CHY citrate lyase, alpha G4273_RS16395 ENOG4107QPK )-transporter G4273_RS16400 ENOG4105KTS ribonuclease G4273_RS16405 ENOG4105NXH GreA GreB family elongation factor G4273_RS16410 ENOG4108U51 Universal stress protein G4273_RS16415 ENOG4108JU3 Alkyl hydroperoxide reductase G4273_RS16420 ENOG4105D3R alkyl hydroperoxide reductase G4273_RS16425 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase G4273_RS16430 ENOG4105DQS Transcriptional regulator G4273_RS16435 ENOG4105BZV Phosphoadenosine phosphosulfate reductase G4273_RS16440 ENOG4105GTN ParB Domain Protein Nuclease G4273_RS16450 ENOG4107SCQ Iron-containing alcohol dehydrogenase G4273_RS16455 ENOG4105VCD cytoplasmic protein G4273_RS16460 ENOG4105D22 carbon starvation protein G4273_RS16465 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) G4273_RS16470 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G4273_RS16475 ENOG4105WQI isochorismatase G4273_RS16480 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G4273_RS16485 ENOG4105E4F Isochorismate synthase G4273_RS16490 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein G4273_RS16500 ENOG4105DQ5 transport system permease protein G4273_RS16505 ENOG4105TVJ transport system, permease G4273_RS16510 ENOG4105E0A ABC, transporter G4273_RS16515 ENOG4108QY5 Ferric enterobactin transport protein G4273_RS16520 ENOG4105C0W non-ribosomal peptide synthetase G4273_RS16525 ENOG41085A6 mbth domain-containing protein G4273_RS16530 ENOG4105E93 esterase G4273_RS16535 ENOG4107RNH Outer membrane receptor FepA G4273_RS16540 ENOG4108TSE Transferase G4273_RS16555 ENOG4105WQ6 Membrane G4273_RS16560 ENOG4105MSB protein, conserved in bacteria G4273_RS16565 ENOG4108RCM Nitroreductase G4273_RS16570 ENOG4105CUY Mechanosensitive ion channel G4273_RS16575 ENOG4105C85 amino acid G4273_RS16580 ENOG4108IJF Heavy metal efflux pump, CzcA G4273_RS16585 ENOG4105EP1 Efflux transporter rnd family, mfp subunit G4273_RS16590 ENOG410624V efflux system protein G4273_RS16595 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G4273_RS16600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4273_RS16605 ENOG4105GR3 Histidine kinase G4273_RS16610 ENOG410802X bacteriophage n4 adsorption protein b G4273_RS16615 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit G4273_RS16620 ENOG4105QUW G4273_RS16625 ENOG4108NC2 Outer membrane protease G4273_RS16630 ENOG4108WF3 methyltransferase G4273_RS16660 ENOG4105WQ3 Rna-binding protein G4273_RS16665 ENOG4105S2T inner membrane protein YbcI G4273_RS16675 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G4273_RS16690 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G4273_RS16695 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G4273_RS16700 ENOG4105C5B carbamate kinase G4273_RS16705 ENOG4105G5A Protein of unknown function (DUF2877) G4273_RS16710 ENOG4107REC cytoplasmic protein G4273_RS16715 ENOG4107R1Q Membrane protein FdrA G4273_RS16720 ENOG4105DG4 malate L-lactate dehydrogenase G4273_RS16725 ENOG4105CE7 Amidase, hydantoinase carbamoylase family G4273_RS16730 ENOG4105S0E allantoin catabolism protein G4273_RS16735 ENOG4105BZW Glycerate kinase G4273_RS16740 ENOG4105DTE Xanthine uracil vitamin C permease G4273_RS16750 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G4273_RS16755 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G4273_RS16760 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G4273_RS16765 ENOG41060W2 glyoxylate carboligase G4273_RS16770 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region G4273_RS16780 ENOG4107653 Transcriptional regulator G4273_RS16785 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) G4273_RS16790 ENOG4105CV6 ABC transporter, permease G4273_RS16795 ENOG4108I0Y (ABC) transporter G4273_RS16800 ENOG4108UJV acyl-CoA thioesterase i G4273_RS16805 ENOG4105E1F short-chain dehydrogenase reductase G4273_RS16810 ENOG4107QR8 Thioredoxin G4273_RS16815 ENOG4105C4B ABC transporter, permease G4273_RS16820 ENOG41083J0 (ABC) transporter G4273_RS16825 ENOG4107QX8 SPFH domain, Band 7 family protein G4273_RS16830 ENOG4105G5H Membrane G4273_RS16855 ENOG4108Z6Z Transcriptional regulator G4273_RS16860 ENOG4107RY6 amino acid G4273_RS16865 ENOG4105CSV Glutaminase G4273_RS16870 ENOG4105C59 p-type ATPase G4273_RS16875 ENOG4105MBR gumn family G4273_RS16880 ENOG4108Z66 YbaK ebsC protein G4273_RS16885 ENOG4105CGH 5'-nucleotidase G4273_RS16890 ENOG4105EU0 Major facilitator Superfamily G4273_RS16895 ENOG4105CKD glutathione-regulated potassium-efflux system protein G4273_RS16900 ENOG4107RE1 Inosine-guanosine kinase G4273_RS16905 ENOG4105F2M alpha beta hydrolase fold-3 domain protein G4273_RS16935 ENOG4107QMP dna polymerase iii subunits gamma and tau G4273_RS16945 ENOG4105WD1 Membrane G4273_RS16950 ENOG4108URS primosomal replication protein n'' G4273_RS16955 ENOG4106428 Protein of unknown function (DUF2496) G4273_RS16960 ENOG4105EGS Mechanosensitive ion channel G4273_RS16965 ENOG4107XI7 Tetr family transcriptional regulator G4273_RS16970 ENOG4105C1P efflux transporter, rnd family, mfp subunit G4273_RS16975 ENOG4105BZS acriflavin resistance protein G4273_RS16980 ENOG4108UKR Biofilm formation regulator YbaJ G4273_RS16985 ENOG4105KF5 hemolysin expression-modulating protein G4273_RS16990 ENOG4108UW5 maltose o-acetyltransferase G4273_RS16995 ENOG4105GSJ Inner membrane protein ylaC G4273_RS17000 ENOG41066DG (EAL) domain protein G4273_RS17005 ENOG4105KCV RNA signal recognition particle 4.5S RNA G4273_RS17015 ENOG41080UX Methyltransferase G4273_RS17020 ENOG4108MNP Glycoprotein polysaccharide metabolism G4273_RS17025 ENOG4105C29 acyl-CoA thioesterase G4273_RS17030 ENOG4105BZU Histidine kinase G4273_RS17035 ENOG4108YZA Nitrogen regulatory protein pii G4273_RS17040 ENOG4105BZ1 (ABC) transporter G4273_RS17045 ENOG4105BZ1 (ABC) transporter G4273_RS17050 ENOG4108XM1 transcriptional regulator AsnC family G4273_RS17060 ENOG4108NFA extracellular solute-binding protein G4273_RS17070 ENOG4108TGP Thioesterase superfamily protein G4273_RS17075 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein G4273_RS17080 ENOG4105EIN peptidylprolyl cis-trans isomerase G4273_RS17085 ENOG4105K70 DNA-binding protein G4273_RS17090 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G4273_RS17105 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G4273_RS17110 ENOG4105M85 Bola protein G4273_RS17115 ENOG4105IEY (LipO)protein G4273_RS17120 ENOG4105EYM Major Facilitator superfamily G4273_RS17125 ENOG4105E2S oxidase) subunit II G4273_RS17130 ENOG4105BZ9 Cytochrome C oxidase, subunit I G4273_RS17135 ENOG4105CCU oxidase (Subunit III) G4273_RS17140 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G4273_RS17150 ENOG4107RDB Major Facilitator G4273_RS17160 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G4273_RS17165 ENOG4107S0N DJ-1 family G4273_RS17180 ENOG4105CTB Polyprenyl synthetase G4273_RS17190 ENOG4105CPC Aldo Keto reductase G4273_RS17195 ENOG4108ZAI phosphatidylglycerophosphatase a G4273_RS17200 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G4273_RS17210 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G4273_RS17215 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G4273_RS17225 ENOG4108KIC (LipO)protein G4273_RS17230 ENOG4105DRB nucleoside-specific channel-forming protein G4273_RS17235 ENOG4105N1F Hnh endonuclease G4273_RS17240 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G4273_RS17245 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G4273_RS17250 ENOG4105VIE preprotein translocase, subunit YajC G4273_RS17260 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G4273_RS17265 ENOG4108ZYK Acyl carrier protein phosphodiesterase G4273_RS17270 ENOG4107R28 alpha amylase, catalytic region G4273_RS17275 ENOG4105C85 amino acid G4273_RS17280 ENOG4105CWM branched-chain amino acid transport system II carrier protein G4273_RS17285 ENOG4105BZU Histidine kinase G4273_RS17290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4273_RS17295 ENOG4107RH8 nuclease SbcCD subunit D G4273_RS17300 ENOG4105EYH Exonuclease G4273_RS17305 ENOG4105F27 Major Facilitator G4273_RS17310 ENOG4105DKQ ROK family G4273_RS17335 ENOG4105HBA AroM protein G4273_RS17340 ENOG4105SS3 G4273_RS17355 ENOG4105II7 pyrroline-5-carboxylate reductase G4273_RS17360 ENOG4105BZU Histidine kinase G4273_RS17365 ENOG4105VIF phosphate starvation-inducible protein G4273_RS17370 ENOG4105G6Z alkaline phosphatase G4273_RS17385 ENOG4105CPF Cell wall formation (By similarity) G4273_RS17390 ENOG4105UNH Membrane G4273_RS17395 ENOG4105FR5 inner membrane protein YaiY G4273_RS17400 ENOG4107QS8 (LipO)protein G4273_RS17405 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 G4273_RS17410 ENOG4107R6D beta-lactam binding protein AmpH G4273_RS17415 ENOG4108PNB DNA-binding transcriptional regulator G4273_RS17425 ENOG4105D52 delta-aminolevulinic acid dehydratase G4273_RS17430 ENOG4105E2B Taurine dioxygenase G4273_RS17435 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G4273_RS17440 ENOG4108IY8 ABC, transporter G4273_RS17445 ENOG4106FTQ Taurine ABC transporter, periplasmic G4273_RS17450 ENOG4107W19 lmbE family G4273_RS17455 ENOG4108PBI Polysaccharide metabolism G4273_RS17465 ENOG4105SRB Uncharacterized protein yaiO G4273_RS17485 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme G4273_RS17495 ENOG4105ETE Transcriptional regulator (LacI family G4273_RS17500 ENOG4105CNT hydrolase family 2 G4273_RS17505 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) G4273_RS17510 ENOG4108UW5 maltose o-acetyltransferase G4273_RS17515 ENOG4105DZC cytosine deaminase G4273_RS17520 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin G4273_RS17525 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G4273_RS17530 ENOG4105DXD 2-methylcitrate dehydratase G4273_RS17535 ENOG4105BZN citrate synthase G4273_RS17540 ENOG4105CR4 methylisocitrate lyase G4273_RS17545 ENOG4108JU7 Transcriptional regulator G4273_RS17550 ENOG4105TDT uncharacterized protein yahO G4273_RS17555 ENOG4105E82 cytochrome subunit of dehydrogenase G4273_RS17565 ENOG4105DQ4 alcohol dehydrogenase G4273_RS17570 ENOG4105DZC cytosine deaminase G4273_RS17575 ENOG4105C5B carbamate kinase G4273_RS17580 ENOG4107REC cytoplasmic protein G4273_RS17585 ENOG4107R1Q Membrane protein FdrA G4273_RS17590 ENOG4105N16 Protein of unknown function (DUF2877) G4273_RS17595 ENOG4107SNB ankyrin repeat protein YahD G4273_RS17600 ENOG4105SZ2 membrAne G4273_RS17605 ENOG4108NUU Transcriptional regulator G4273_RS17610 ENOG4105BZU Histidine kinase G4273_RS17615 ENOG4105C94 Transporter G4273_RS17630 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G4273_RS17635 ENOG4108W9T type 1 fimbriae regulatory protein G4273_RS17640 ENOG4105BZU Histidine kinase G4273_RS17665 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) G4273_RS17670 ENOG4107QR9 Iron-sulfur cluster binding protein G4273_RS17675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4273_RS17680 ENOG4108K01 transcriptional regulator G4273_RS17685 ENOG4107QN2 dihydrolipoyl dehydrogenase G4273_RS17690 ENOG41066GK UPF0379 protein ykgI G4273_RS17695 ENOG4108KBJ Inner membrane protein YkgB G4273_RS17700 ENOG4105CV8 reductase G4273_RS17720 ENOG4107SET aldo keto reductase G4273_RS17725 ENOG4105EQ2 LysR family Transcriptional regulator G4273_RS17730 ENOG410642W LysR family Transcriptional regulator G4273_RS17735 ENOG4105ENX hydrolase G4273_RS17740 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4273_RS17785 ENOG4106PYX Receptor G4273_RS17795 ENOG4105PI0 Ferredoxin G4273_RS17805 ENOG4105R3P Inner membrane protein yagU G4273_RS17910 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G4273_RS17920 ENOG4105FCK Membrane G4273_RS17940 ENOG4105CIN aminoacyl-histidine dipeptidase G4273_RS17945 ENOG4108S2Y peptide Chain Release factor G4273_RS17955 ENOG4108HYG acetyltransferase G4273_RS17985 ENOG4108YS0 lipoprotein YafL G4273_RS17990 ENOG4105F7V ErfK ybiS ycfS ynhG family protein G4273_RS17995 ENOG4105E7A Glutamine amidotransferase G4273_RS18005 ENOG4107QPN acyl-Coa dehydrogenase G4273_RS18010 ENOG4108WN0 inhibitor of vertebrate lysozyme G4273_RS18015 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G4273_RS18055 ENOG4105CS6 Rhs element vgr protein G4273_RS18060 ENOG4108WC9 type VI secretion system effector, hcp1 family G4273_RS18110 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G4273_RS18140 ENOG410600K aminopeptidase G4273_RS18150 ENOG4107RZZ dna polymerase iii epsilon subunit G4273_RS18160 ENOG4105D1A Methyltransferase G4273_RS18170 ENOG4105E9H Lytic Murein transglycosylase G4273_RS18175 ENOG4105F2W methyltransferase G4273_RS18185 ENOG4105HEI LysR family (Transcriptional regulator G4273_RS18190 ENOG4105CV8 reductase G4273_RS18225 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G4273_RS18230 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G4273_RS18235 ENOG4108UMI ABC transporter, permease G4273_RS18240 ENOG4105D01 (LipO)protein G4273_RS18245 ENOG4108R8X outer membrane lipoprotein G4273_RS18250 ENOG4108R96 Methyltransferase, YaeB family G4273_RS18260 ENOG4108UY0 (LipO)protein G4273_RS18265 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion G4273_RS18270 ENOG4108YZN class I peptide chain release factor G4273_RS18275 ENOG4108VWS Yaeq family G4273_RS18285 ENOG4105M1T rho-binding antiterminator G4273_RS18290 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G4273_RS18295 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase G4273_RS18300 ENOG4105CXN decarboxylase G4273_RS18310 ENOG4105C0B DNA polymerase III (alpha subunit) G4273_RS18335 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G4273_RS18340 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) G4273_RS18350 ENOG4105DZP Membrane-associated zinc metalloprotease G4273_RS18355 ENOG4105KNE Phosphatidate cytidylyltransferase G4273_RS18360 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G4273_RS18365 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G4273_RS18390 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G4273_RS18415 ENOG4105C0H protease G4273_RS18430 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G4273_RS18435 ENOG4105EN6 Membrane G4273_RS18460 ENOG4105S6R Iron-hydroxamate transporter permease subunit G4273_RS18465 ENOG4105J76 Periplasmic binding protein G4273_RS18470 ENOG4105E0A ABC, transporter G4273_RS18475 ENOG4105E0K tonB-dependent siderophore receptor G4273_RS18480 ENOG4105BZ4 penicillin-binding protein G4273_RS18485 ENOG4105CQ7 ATP-dependent helicase G4273_RS18490 ENOG4107XID 2'-5' rna ligase G4273_RS18505 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G4273_RS18510 ENOG4105DJ0 Poly(A) Polymerase G4273_RS18515 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G4273_RS18525 ENOG4108VEV chaperone G4273_RS18530 ENOG4105CW0 outer membrane usher protein G4273_RS18535 ENOG4108XEY fimbrial-like adhesin protein G4273_RS18540 ENOG4105SYG Fimbrial protein G4273_RS18545 ENOG4105SN2 fimbrial-like adhesin protein G4273_RS18550 ENOG4105P0Q fimbrial-like protein YadC G4273_RS18560 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G4273_RS18565 ENOG4108A32 Transposase G4273_RS18575 ENOG4107BJW polysaccharide deacetylase G4273_RS18580 ENOG4108YTN IIa component G4273_RS18585 ENOG4105E3A (ABC) transporter G4273_RS18590 ENOG4105DA5 (ABC) transporter G4273_RS18595 ENOG41077A9 carbonic anhydrase G4273_RS18600 ENOG4108UGV hypoxanthine phosphoribosyltransferase G4273_RS18605 ENOG4105DZG Dehydrogenase G4273_RS18610 ENOG4105E3B Multicopper oxidase G4273_RS18615 ENOG4108ZRK uncharacterized protein yacC G4273_RS18635 ENOG4107QIJ Aconitate hydratase 2 G4273_RS18640 ENOG4108NST exported protein G4273_RS18645 ENOG4107QN2 dihydrolipoyl dehydrogenase G4273_RS18650 ENOG4107QSN dihydrolipoamide acetyltransferase G4273_RS18655 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G4273_RS18660 ENOG41073TP transcriptional regulator G4273_RS18665 ENOG41060S4 immunity protein G4273_RS18675 ENOG41060S4 immunity protein G4273_RS18685 ENOG4105GMB type VI secretion system effector, hcp1 family G4273_RS18690 ENOG4105C85 amino acid G4273_RS18695 ENOG4106A72 regulatory protein AmpE G4273_RS18700 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G4273_RS18705 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G4273_RS18710 ENOG4108ZUW Major pilin subunit G4273_RS18715 ENOG4107QHF type ii secretion system protein e G4273_RS18720 ENOG4105D7Q type ii secretion system G4273_RS18735 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G4273_RS18750 ENOG4105M6F mutator MutT protein G4273_RS18770 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G4273_RS18775 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G4273_RS18780 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G4273_RS18785 ENOG4105CPF Cell wall formation (By similarity) G4273_RS18800 ENOG4105CNI cell division protein FtsW G4273_RS18805 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G4273_RS18815 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G4273_RS18820 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G4273_RS18825 ENOG4105CJN penicillin-binding protein G4273_RS18830 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G4273_RS18845 ENOG4107B7Y DNA-binding transcriptional regulator FruR G4273_RS18855 ENOG4108ZP8 Acetolactate synthase small subunit G4273_RS18860 ENOG4105C7K acetolactate synthase G4273_RS18870 ENOG41064T2 transcriptional regulator, lysR family G4273_RS18910 ENOG4105DP9 ABC transporter G4273_RS18915 ENOG4106SMU thiamine transporter membrane protein G4273_RS18920 ENOG4107T0D ABC, transporter G4273_RS18925 ENOG4108KF1 Membrane G4273_RS18930 ENOG41063TF transcriptional regulator (AraC G4273_RS18945 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G4273_RS18950 ENOG4105CQ2 DNA polymerase G4273_RS18960 ENOG4105D3G Pseudouridine synthase G4273_RS18965 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) G4273_RS18970 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G4273_RS18975 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G4273_RS18980 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G4273_RS19010 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) G4273_RS19025 ENOG4105C54 Major Facilitator superfamily G4273_RS19030 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein G4273_RS19035 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G4273_RS19065 ENOG4105CEY Amp-dependent synthetase and ligase G4273_RS19070 ENOG4106YT9 Enoyl-CoA hydratase G4273_RS19080 ENOG4108XNW Transcriptional activatory protein CaiF G4273_RS19085 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G4273_RS19090 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G4273_RS19115 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase G4273_RS19130 ENOG4105DTN riboflavin biosynthesis protein ribF G4273_RS19135 ENOG410647N response to DNA damage stimulus G4273_RS19145 ENOG41063Z6 transcriptional regulator, lysR family G4273_RS19160 ENOG41061MV Arylsulfatase G4273_RS19170 ENOG4105WI6 cell killing protein encoded within cryptic prophage G4273_RS19190 ENOG4108QUJ UPF0174 protein YaaW G4273_RS19195 ENOG4106HK8 GPR1 FUN34 yaaH family protein G4273_RS19200 ENOG4108RIR Molybdenum cofactor biosynthesis protein G4273_RS19210 ENOG4105BZG amino acid carrier protein G4273_RS19220 ENOG41062C6 Protein of unknown function (DUF2502) G4273_RS19225 ENOG4105D98 threonine synthase G4273_RS19235 ENOG4105CFH Aspartokinase G4273_RS19245 ENOG4106FVC RNA methyltransferase G4273_RS19250 ENOG410759A G4273_RS19255 ENOG41065U4 response regulator G4273_RS19260 ENOG4105CT7 inner membrane cred family protein G4273_RS19265 ENOG4105EB3 Histidine kinase G4273_RS19270 ENOG4105E3W Two component transcriptional regulator (Winged helix family G4273_RS19275 ENOG4108RH0 Crea protein G4273_RS19280 ENOG4105UEI Transcriptional Regulator AraC Family G4273_RS19300 ENOG4107SC1 transglycosylase G4273_RS19305 ENOG4105C5H ABC transporter G4273_RS19315 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system G4273_RS19320 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase G4273_RS19325 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G4273_RS19330 ENOG4105EAC phosphoserine phosphatase G4273_RS19335 ENOG41062Z9 Membrane G4273_RS19345 ENOG4105EUP HipA domain protein G4273_RS19350 ENOG4105D3A purine nucleoside phosphorylase DeoD-type G4273_RS19370 ENOG4105G0K glycine radical enzyme YjjI family G4273_RS19375 ENOG41076CZ activating enzyme G4273_RS19380 ENOG4105EYA deoxyribonuclease G4273_RS19385 ENOG4108NRW Phospholipase, patatin family G4273_RS19395 ENOG4105K3G Periplasmic Protein G4273_RS19405 ENOG4105PAD Hydrolase G4273_RS19410 ENOG4105KEG ribosomal-protein-alanine acetyltransferase G4273_RS19415 ENOG4108WPU DNA polymerase III subunit psi G4273_RS19420 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G4273_RS19440 ENOG4105YBH Protein of unknown function (DUF1435) G4273_RS19445 ENOG4108819 ferric iron reductase G4273_RS19450 ENOG4108T94 DNA-binding transcriptional activator BglJ G4273_RS19455 ENOG4108N8T regulatoR G4273_RS19460 ENOG4105DWK Membrane G4273_RS19475 ENOG4106CVF DNA replication protein G4273_RS19480 ENOG4105RI1 glycoprotein receptor G4273_RS19490 ENOG4105CPQ Dehydrogenase G4273_RS19495 ENOG410617M Transcriptional regulator G4273_RS19500 ENOG4108I5G Major Facilitator superfamily G4273_RS19505 ENOG4105C8Q Methyl-accepting chemotaxis G4273_RS19510 ENOG4105D22 carbon starvation protein G4273_RS19515 ENOG4105VCD cytoplasmic protein G4273_RS19520 ENOG4105CKI cobalamin synthesis protein G4273_RS19535 ENOG4106H3A restriction G4273_RS19540 ENOG4105CVR type I restriction-modification system G4273_RS19545 ENOG4105EKX Restriction modification system DNA (Specificity G4273_RS19550 ENOG4105DZR Type I site-specific deoxyribonuclease G4273_RS19565 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4273_RS19575 ENOG4106BRA Membrane G4273_RS19580 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase G4273_RS19585 ENOG4105CIZ coA-substrate-specific enzyme activase G4273_RS19600 ENOG4105CBP Major Facilitator G4273_RS19605 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) G4273_RS19610 ENOG41074DU domain protein G4273_RS19615 ENOG4108P2H Inner membrane protein YjiG G4273_RS19620 ENOG4105DYB Isoaspartyl dipeptidase G4273_RS19625 ENOG4107YNJ LysR family Transcriptional regulator G4273_RS19635 ENOG4106PZD Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway G4273_RS19640 ENOG4105C6F GntR Family Transcriptional Regulator G4273_RS19645 ENOG4105DEI Mannitol dehydrogenase G4273_RS19655 ENOG4107EFN gluconate transport system permease 3 G4273_RS19660 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin G4273_RS19665 ENOG4108T65 Fimbrial G4273_RS19670 ENOG4108SQA Fimbrial G4273_RS19675 ENOG4105CW0 outer membrane usher protein G4273_RS19680 ENOG4108NAE Fimbrial chaperone protein G4273_RS19685 ENOG4108S54 Fimbrial protein G4273_RS19695 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off G4273_RS19700 ENOG4108W9T type 1 fimbriae regulatory protein G4273_RS19705 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria G4273_RS19710 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) G4273_RS19730 ENOG4105YCT UPF0386 protein G4273_RS19735 ENOG41080VW acetyltransferase G4273_RS19740 ENOG4105DTA methyltransferase G4273_RS19745 ENOG4105DTA methyltransferase G4273_RS19755 ENOG4105CN9 Peptidase m42 family protein G4273_RS19760 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) G4273_RS19765 ENOG4105DT3 PTS system, galactitol-specific IIc component G4273_RS19770 ENOG4106P19 photosystem i assembly btpa G4273_RS19775 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) G4273_RS19780 ENOG4108RK0 3-epimerase G4273_RS19785 ENOG4108PQ7 sgc region transcriptional regulator G4273_RS19790 ENOG4106P37 HTH-type transcriptional regulator YjhI G4273_RS19795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G4273_RS19800 ENOG4105C01 Dihydroxy-acid dehydratase G4273_RS19805 ENOG4105C6Z Gluconate G4273_RS19810 ENOG4105DKT Transcriptional regulator G4273_RS19830 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4273_RS19840 ENOG4108YGG dna repair protein G4273_RS19845 ENOG4106549 Antirestriction protein G4273_RS19850 ENOG4106H6R UPF0380 protein G4273_RS19865 ENOG4108KZE transcriptional regulator G4273_RS19870 ENOG4105TS0 gtp-binding protein G4273_RS19905 ENOG4105DFD Na H antiporter G4273_RS19910 ENOG4105C87 Aminotransferase class I and II G4273_RS19935 ENOG4105KNY Microcompartments protein G4273_RS19940 ENOG4105KNY Microcompartments protein G4273_RS19945 ENOG4105KNY Microcompartments protein G4273_RS19950 ENOG4105C0A alcohol dehydrogenase G4273_RS19960 ENOG4105C0A alcohol dehydrogenase G4273_RS19965 ENOG4105C6N Formate acetyltransferase G4273_RS19970 ENOG4105F1A Pyruvate formate-lyase G4273_RS19975 ENOG4105KNY Microcompartments protein G4273_RS19980 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) G4273_RS19995 ENOG410814C multidrug resistance protein G4273_RS20005 ENOG4105W8I Transcriptional regulator G4273_RS20015 ENOG4105BZC d-serine deaminase G4273_RS20050 ENOG4105D5K Hemolysin activator protein G4273_RS20060 ENOG4106QAN G4273_RS20080 ENOG4105NI8 Cytosine-specific methyltransferase G4273_RS20085 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G4273_RS20105 ENOG4105ES5 Histidine kinase G4273_RS20110 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4273_RS20120 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G4273_RS20130 ENOG4108RC6 RTX toxin G4273_RS20135 ENOG4107V48 Hemolysin-type calcium-binding G4273_RS20140 ENOG4108JJA ABC, transporter G4273_RS20145 ENOG4105C42 Type I secretion membrane fusion protein (HlyD G4273_RS20175 ENOG4108YXQ IS66 Orf2 family protein G4273_RS20180 ENOG4105E5H Transposase G4273_RS20185 ENOG4108R86 Transcriptional regulator G4273_RS20200 ENOG4108SB3 DoxX Family G4273_RS20265 ENOG4108ZJG MrfB protein G4273_RS20270 ENOG4106PG1 outer membrane usher protein G4273_RS20275 ENOG4106P2F Pfam:Pili_assembly_C G4273_RS20285 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR G4273_RS20305 ENOG4105D70 Integrase catalytic subunit G4273_RS20310 ENOG4105F5W AtP-binding protein G4273_RS20335 ENOG4105DQ4 alcohol dehydrogenase G4273_RS20340 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G4273_RS20345 ENOG4105CPQ Dehydrogenase G4273_RS20350 ENOG4105CHR reductase G4273_RS20355 ENOG4105C6Z Gluconate G4273_RS20360 ENOG4105K2J Transcriptional regulator G4273_RS20365 ENOG4105D7A ATP-binding protein G4273_RS20370 ENOG4108K5H permease YjgP YjgQ family protein G4273_RS20375 ENOG4108M8S permease YjgP YjgQ family protein G4273_RS20385 ENOG4105MYG DNA polymerase iii, chi subunit G4273_RS20390 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G4273_RS20395 ENOG4108M3P Membrane G4273_RS20400 ENOG4108MJ3 acetyltransferase G4273_RS20405 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) G4273_RS20410 ENOG4105DBV ornithine carbamoyltransferase G4273_RS20415 ENOG4105XEP YhcH YjgK YiaL family protein G4273_RS20430 ENOG4105DBV ornithine carbamoyltransferase G4273_RS20435 ENOG4105CSX c4-dicarboxylate anaerobic carrier G4273_RS20445 ENOG4107C93 pyrBI operon leader peptide G4273_RS20460 ENOG4105KME endoribonuclease L-psp G4273_RS20465 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G4273_RS20475 ENOG4105D4X repressor G4273_RS20480 ENOG4105C5Y PTS System G4273_RS20485 ENOG4105CG3 alpha amylase, catalytic region G4273_RS20490 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase G4273_RS20495 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) G4273_RS20500 ENOG4108XVM Cytochrome b(562) G4273_RS20505 ENOG4105CMS peptidase U62, modulator of DNA gyrase G4273_RS20510 ENOG4105N42 UPF0307 protein G4273_RS20515 ENOG4105DFU Cell wall formation (By similarity) G4273_RS20525 ENOG41062B0 ABC transporter, permease G4273_RS20530 ENOG4107R9N ABC transporter G4273_RS20535 ENOG4105C2J ABC transporter G4273_RS20540 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator G4273_RS20545 ENOG4105F0N pyrophosphate phospho-hydrolase G4273_RS20550 ENOG4108ZHD aig2 family G4273_RS20555 ENOG4105MA0 exported protein G4273_RS20560 ENOG4105CFU surface antigen G4273_RS20570 ENOG4105C37 (CBS) domain G4273_RS20575 ENOG41061GZ Protein of unknown function (DUF1107) G4273_RS20580 ENOG4108UUE Transcriptional regulator G4273_RS20585 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase G4273_RS20590 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic G4273_RS20595 ENOG4105KVH Transcriptional regulator G4273_RS20600 ENOG4105ECR NmrA family G4273_RS20605 ENOG4105DXC membrane G4273_RS20620 ENOG4108V1T peptidylprolyl cis-trans isomerase G4273_RS20625 ENOG4105FHY Opacity-associated protein A G4273_RS20635 ENOG4105CHR reductase G4273_RS20645 ENOG4105E39 Enoyl-CoA hydratase G4273_RS20650 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G4273_RS20660 ENOG4105DPW Major facilitator superfamily MFS_1 G4273_RS20680 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G4273_RS20695 ENOG4105KIT UPF0379 protein yjfY G4273_RS20700 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G4273_RS20710 ENOG4105H6Q decarboxylase G4273_RS20720 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport G4273_RS20725 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC G4273_RS20740 ENOG4108MXZ Esterase G4273_RS20745 ENOG4105WSB biofilm stress and motility protein A G4273_RS20750 ENOG4105S17 UPF0379 protein yjfN G4273_RS20755 ENOG4105CSU acyl-Coa dehydrogenase G4273_RS20760 ENOG4106032 Glutathionylspermidine synthase G4273_RS20765 ENOG4108KXT Conserved Protein G4273_RS20770 ENOG4105Z6B inner membrane protein yjfl G4273_RS20775 ENOG4107VNS Protein of unknown function (DUF2491) G4273_RS20780 ENOG4108P9J Phage shock protein A G4273_RS20785 ENOG4105FUX Conserved Protein G4273_RS20790 ENOG4105C2N RNA methyltransferase TrmH family group 3 G4273_RS20795 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G4273_RS20815 ENOG4105EPW hflc protein G4273_RS20820 ENOG4107QJR hflk protein G4273_RS20825 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G4273_RS20845 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4273_RS20850 ENOG4105K8N protein family UPF0079, ATPase G4273_RS20855 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G4273_RS20860 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G4273_RS20900 ENOG4105EGS Mechanosensitive ion channel G4273_RS20905 ENOG4107SC7 Inner membrane transporter yjeM G4273_RS20915 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G4273_RS20920 ENOG4105E33 succinate dehydrogenase G4273_RS20935 ENOG41066YJ Beta-lactamase G4273_RS20940 ENOG4105QNF Outer membrane lipoprotein G4273_RS20945 ENOG4105KPY Small multidrug resistance protein G4273_RS20950 ENOG4106BSU Entericidin B G4273_RS20955 ENOG4107PEH Entericidin EcnA/B family G4273_RS20965 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G4273_RS20970 ENOG4105MTB Uncharacterized protein YjeJ G4273_RS20975 ENOG4108ZVF (LipO)protein G4273_RS20990 ENOG4105DVH amino acid G4273_RS20995 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 G4273_RS21000 ENOG4108IJ0 Aspartate ammonia-lyase G4273_RS21005 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter G4273_RS21015 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G4273_RS21020 ENOG4108SIC Transcriptional regulator G4273_RS21040 ENOG4108I6E Sulfatase G4273_RS21045 ENOG4105T40 surface antigen msp4 family protein G4273_RS21060 ENOG41067TZ transcriptional regulator, MarR family G4273_RS21080 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR G4273_RS21090 ENOG4106P2F Pfam:Pili_assembly_C G4273_RS21095 ENOG4106PG1 outer membrane usher protein G4273_RS21100 ENOG4108ZJG MrfB protein G4273_RS21145 ENOG4105CXY transporter G4273_RS21150 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC G4273_RS21160 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta G4273_RS21190 ENOG4105BZV Phosphoadenosine phosphosulfate reductase G4273_RS21215 ENOG4105D05 Receptor G4273_RS21240 ENOG4105TS0 gtp-binding protein G4273_RS21245 ENOG4108KZE transcriptional regulator G4273_RS21260 ENOG4106H6R UPF0380 protein G4273_RS21265 ENOG4105MFG Antirestriction protein G4273_RS21270 ENOG4108YGG dna repair protein G4273_RS21280 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4273_RS21320 ENOG4105BZU Histidine kinase G4273_RS21325 ENOG4108M3R transcriptional activator CadC G4273_RS21330 ENOG4105D5Q Arginine ornithine antiporter G4273_RS21335 ENOG4105CXN decarboxylase G4273_RS21340 ENOG4105DUX Transporter G4273_RS21345 ENOG4105CRK lysyL-tRNA synthetase G4273_RS21360 ENOG410830R acetyltransferase G4273_RS21365 ENOG4105VR1 Pfam:DUF1271 G4273_RS21370 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G4273_RS21375 ENOG4108MRH transcriptional regulatory protein G4273_RS21380 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter G4273_RS21385 ENOG4107GFK fumarate G4273_RS21390 ENOG4108R5S membrane G4273_RS21395 ENOG4105F8D glycoside hydrolase family 4 G4273_RS21400 ENOG4108K2B transcriptional regulator G4273_RS21405 ENOG4105CXN decarboxylase G4273_RS21410 ENOG4106ZGR Transcriptional regulator G4273_RS21415 ENOG4105D5Q Arginine ornithine antiporter G4273_RS21420 ENOG4105DIJ Phosphoethanolamine transferase G4273_RS21425 ENOG4105XJC Two component transcriptional regulator (Winged helix family G4273_RS21430 ENOG4105ECM Sensor protein basS pmrB G4273_RS21440 ENOG4105CSH Transporter G4273_RS21445 ENOG4108YIV G4273_RS21450 ENOG4108F5E vimentin G4273_RS21455 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G4273_RS21460 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase G4273_RS21470 ENOG4105EHI Phosphonate ABC transporter, periplasmic G4273_RS21480 ENOG4107RJJ Transcriptional regulator G4273_RS21485 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG G4273_RS21490 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH G4273_RS21495 ENOG4105EKV Phosphonate metabolism protein G4273_RS21500 ENOG4105FT8 Phosphonate metabolism G4273_RS21505 ENOG4105ENV phosphonate C-P lyase system protein PhnK G4273_RS21510 ENOG4105HRV phosphonate c-p lyase system protein phnl G4273_RS21515 ENOG4105FD8 phosphonate metabolism protein PhnM G4273_RS21520 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) G4273_RS21525 ENOG410849A acetyltransferase, (GNAT) family G4273_RS21530 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein G4273_RS21540 ENOG4108YZG isomerase G4273_RS21545 ENOG4105NYY transcriptional regulator, RpiR G4273_RS21550 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G4273_RS21555 ENOG4105C2J ABC transporter G4273_RS21560 ENOG4105CNN ABC, transporter G4273_RS21565 ENOG4105UP7 3-epimerase G4273_RS21570 ENOG4107TFG D-allose kinase G4273_RS21575 ENOG4105EUZ Beta-lactamase domain protein G4273_RS21585 ENOG4105J12 Multidrug resistance protein mdtN G4273_RS21590 ENOG4108MI0 Resistance protein G4273_RS21595 ENOG4105ETP RND efflux system, outer membrane lipoprotein G4273_RS21610 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4273_RS21615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4273_RS21620 ENOG4105C3U ABC transporter G4273_RS21625 ENOG4108JQ7 (ABC) transporter G4273_RS21630 ENOG41082ND Uncharacterized protein yjcO G4273_RS21635 ENOG4105CK2 sodium dicarboxylate symporter G4273_RS21640 ENOG4108W0S formate-dependent nitrite reductase complex G4273_RS21650 ENOG4108QKW cytochrome c-type biogenesis protein G4273_RS21655 ENOG4105DVI reductase, NrfD G4273_RS21660 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G4273_RS21665 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit G4273_RS21675 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G4273_RS21680 ENOG41062QD Membrane G4273_RS21690 ENOG41067MG lrgb family G4273_RS21700 ENOG4105CMU LysR family (Transcriptional regulator G4273_RS21705 ENOG4105EEQ Na H antiporter G4273_RS21710 ENOG4105C7N Xanthine uracil vitamin C permease G4273_RS21715 ENOG4108Z4X TRANSCRIPTIONal G4273_RS21720 ENOG4108W3Q Transcriptional regulator G4273_RS21725 ENOG4108M8H domain protein G4273_RS21730 ENOG4105PMV Membrane G4273_RS21735 ENOG4108UUM single-stranded DNA-binding protein G4273_RS21740 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G4273_RS21745 ENOG4105MSB protein, conserved in bacteria G4273_RS21750 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme G4273_RS21755 ENOG4105F0S class B acid phosphatase G4273_RS21760 ENOG4105CQZ Histidine kinase G4273_RS21765 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4273_RS21770 ENOG4105DG4 malate L-lactate dehydrogenase G4273_RS21775 ENOG4107QPK )-transporter G4273_RS21780 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G4273_RS21785 ENOG4105CMV Succinyl-CoA synthetase subunit beta G4273_RS21790 ENOG4107QN2 dihydrolipoyl dehydrogenase G4273_RS21795 ENOG4105C7S Dehydrogenase G4273_RS21800 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G4273_RS21805 ENOG4105CGF Aromatic amino acid aminotransferase G4273_RS21810 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G4273_RS21815 ENOG4105CDU Replicative dna helicase G4273_RS21820 ENOG4105ETE Transcriptional regulator (LacI family G4273_RS21825 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G4273_RS21830 ENOG4106YT9 Enoyl-CoA hydratase G4273_RS21840 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G4273_RS21845 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G4273_RS21850 ENOG4105P4Z Phage shock protein G G4273_RS21855 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G4273_RS21860 ENOG4105MYN Zinc uptake regulation protein G4273_RS21865 ENOG4105VDW Csbd family G4273_RS21870 ENOG4107R73 Mate efflux family protein G4273_RS21880 ENOG41080IJ Diacylglycerol kinase G4273_RS21900 ENOG4107W52 maltose operon periplasmic protein G4273_RS21910 ENOG4108IJ9 (ABC) transporter G4273_RS21915 ENOG4107FKK extracellular solute-binding protein family 1 G4273_RS21920 ENOG4105D56 permease protein G4273_RS21925 ENOG4105EG2 ABC transporter, permease G4273_RS21940 ENOG4105E3R (LipO)protein G4273_RS21945 ENOG4108Q9C Periplasmic Protein G4273_RS21950 ENOG4108MDC (LipO)protein G4273_RS21965 ENOG4105CFH Aspartokinase G4273_RS21970 ENOG4108ZR5 Conserved Protein G4273_RS21975 ENOG4105FE9 pseudouridine synthase G4273_RS21980 ENOG4105DKT Transcriptional regulator G4273_RS21985 ENOG4105CHR reductase G4273_RS21990 ENOG4108XCU pts system G4273_RS21995 ENOG4105KPI PTS system sorbose subfamily IIB component G4273_RS22000 ENOG4105ETZ PTS System G4273_RS22005 ENOG4105F3R pts system mannose fructose sorbose family iid G4273_RS22010 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein G4273_RS22015 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) G4273_RS22020 ENOG4105EAM Na Pi-cotransporter G4273_RS22035 ENOG4105C3R Methionine synthase G4273_RS22040 ENOG41069M3 Transcriptional regulator G4273_RS22050 ENOG4108I9X Isocitrate lyase G4273_RS22055 ENOG4107QP3 malate synthase g G4273_RS22065 ENOG4105K5X acetyltransferase G4273_RS22070 ENOG41062WK cellular response to acidity G4273_RS22100 ENOG4105C12 Phosphoribosylglycinamide synthetase G4273_RS22105 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4273_RS22110 ENOG4105BZU Histidine kinase G4273_RS22115 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism G4273_RS22120 ENOG4108T8B Protein of unknown function (DUF1481) G4273_RS22130 ENOG4105R2J Conserved Protein G4273_RS22155 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G4273_RS22165 ENOG4105D06 uba thif-type nad fad binding protein G4273_RS22170 ENOG4105WHD thiamine biosynthesis protein ThiS G4273_RS22180 ENOG4105D41 biosynthesis protein thiH G4273_RS22215 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G4273_RS22220 ENOG4105PM1 preprotein translocase subunit SecE G4273_RS22255 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G4273_RS22260 ENOG4105D4A Cell wall formation (By similarity) G4273_RS22290 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G4273_RS22300 ENOG4108Y73 Membrane G4273_RS22315 ENOG4105CH2 amidohydrolase G4273_RS22325 ENOG4105C5Q Transcriptional regulator G4273_RS22330 ENOG4108I5G Major Facilitator superfamily G4273_RS22335 ENOG4105CXK mandelate racemase muconate lactonizing G4273_RS22345 ENOG4105CAS nag kinase G4273_RS22350 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G4273_RS22365 ENOG4105DIJ Phosphoethanolamine transferase G4273_RS22370 ENOG4106R3P AraC family transcriptional regulator G4273_RS22375 ENOG4108XCZ PTS System G4273_RS22380 ENOG4108AHH pyruvate formate lyase II activase G4273_RS22390 ENOG4108YRF PTS System G4273_RS22395 ENOG4105DM4 PTS System G4273_RS22400 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G4273_RS22405 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G4273_RS22410 ENOG4105DCT glycerol dehydrogenase G4273_RS22415 ENOG4108XC3 NADH ubiquinone oxidoreductase G4273_RS22420 ENOG4108Q5Y Membrane G4273_RS22430 ENOG4105SYT Methylenetetrahydrofolate reductase G4273_RS22435 ENOG4105CGH 5'-nucleotidase G4273_RS22445 ENOG4105CGH 5'-nucleotidase G4273_RS22450 ENOG4105CGH 5'-nucleotidase G4273_RS22455 ENOG4105DRB nucleoside-specific channel-forming protein G4273_RS22460 ENOG4105CFH Aspartokinase G4273_RS22465 ENOG4105C28 cystathionine G4273_RS22475 ENOG4107S01 Repressor protein MetJ G4273_RS22485 ENOG4105C25 Primosomal protein n' G4273_RS22490 ENOG4105ETE Transcriptional regulator (LacI family G4273_RS22495 ENOG41063M6 Cell Division Protein G4273_RS22510 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase G4273_RS22525 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G4273_RS22535 ENOG4105CBT Fructose-1,6-bisphosphatase G4273_RS22540 ENOG4105DP0 ferredoxin-NADP reductase G4273_RS22550 ENOG41065TG regulatoR G4273_RS22555 ENOG4108VTS Membrane G4273_RS22560 ENOG4105EBK exported protein G4273_RS22575 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G4273_RS22590 ENOG4105FMW periplasmic G4273_RS22595 ENOG4105E3W Two component transcriptional regulator (Winged helix family G4273_RS22600 ENOG4105E0F Histidine kinase G4273_RS22605 ENOG4108RPX mosc domain containing protein G4273_RS22615 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4273_RS22635 ENOG4105DET Rhamnulokinase G4273_RS22675 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G4273_RS22680 ENOG4108MG3 formate dehydrogenase G4273_RS22695 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) G4273_RS22705 ENOG4105SUU thioesterase domain G4273_RS22720 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 G4273_RS22730 ENOG4105CSH Transporter G4273_RS22740 ENOG4105CPQ Dehydrogenase G4273_RS22745 ENOG4105D2M Aldolase G4273_RS22750 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G4273_RS22755 ENOG4108MGF sugar kinase G4273_RS22760 ENOG4105E98 transcriptional regulator DeoR family G4273_RS22765 ENOG4105R9B Major Facilitator G4273_RS22770 ENOG4108KHF Resistance protein G4273_RS22775 ENOG4108K85 Transcriptional regulator G4273_RS22780 ENOG4105CI3 gtp-binding protein typa G4273_RS22785 ENOG4105C5F glutamine synthetase G4273_RS22790 ENOG4105CUX Signal transduction histidine kinase G4273_RS22795 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4273_RS22800 ENOG4106FIY G4273_RS22805 ENOG4105D4P Coproporphyrinogen iii oxidase G4273_RS22820 ENOG4105C2M dna polymerase I G4273_RS22825 ENOG4106HNH Acyl-transferase G4273_RS22835 ENOG4108Z33 Thiol disulfide Interchange Protein G4273_RS22840 ENOG4105E27 serine threonine protein kinase G4273_RS22845 ENOG4105PC1 Conserved Protein G4273_RS22850 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G4273_RS22855 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b G4273_RS22885 ENOG4108RR8 protoporphyrinogen oxidase G4273_RS22890 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) G4273_RS22895 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G4273_RS22905 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) G4273_RS22915 ENOG4108EX3 reductase G4273_RS22920 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G4273_RS22925 ENOG4105MDZ Transcriptional activator rfaH G4273_RS22935 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G4273_RS22940 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G4273_RS22945 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G4273_RS22955 ENOG4105JC1 sterol-binding domain protein G4273_RS22965 ENOG4105CGY Dna recombination protein G4273_RS22970 ENOG4107HP6 Transcriptional regulator G4273_RS22975 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 G4273_RS22980 ENOG4108RTU Aldolase G4273_RS22985 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G4273_RS23000 ENOG4108I5U Uridine phosphorylase G4273_RS23005 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) G4273_RS23010 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G4273_RS23020 ENOG4107R1Q Membrane protein FdrA G4273_RS23025 ENOG4107REC cytoplasmic protein G4273_RS23030 ENOG4105C5B carbamate kinase G4273_RS23040 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin G4273_RS23045 ENOG4105F52 Transcriptional regulator G4273_RS23050 ENOG4106KNT transcriptional regulator G4273_RS23055 ENOG4105CV1 Transketolase (EC 2.2.1.1) G4273_RS23070 ENOG4105GMB type VI secretion system effector, hcp1 family G4273_RS23075 ENOG4105GMB type VI secretion system effector, hcp1 family G4273_RS23090 ENOG4105DZ2 Transcriptional regulator G4273_RS23095 ENOG4105EMK carboxylate amino acid amine transporter G4273_RS23100 ENOG4105DQF Hydrolase G4273_RS23105 ENOG4108EUD Lysophospholipase G4273_RS23110 ENOG410829K Lysine exporter protein (Lyse ygga) G4273_RS23115 ENOG4105CCF Lysine exporter protein (Lyse ygga) G4273_RS23120 ENOG4105C9U ATP-dependent DNA helicase RecQ G4273_RS23125 ENOG4105HDD phospholipase G4273_RS23130 ENOG4108VUY thioesterase Superfamily protein G4273_RS23135 ENOG4105FR1 rard protein G4273_RS23150 ENOG4107QUT magnesium and cobalt transport protein CorA G4273_RS23155 ENOG4108T58 Mg2 transport protein CorA G4273_RS23160 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase G4273_RS23165 ENOG4105C4R Atp-dependent dna helicase G4273_RS23170 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant G4273_RS23180 ENOG4105CT0 Protein of unknown function, DUF484 G4273_RS23190 ENOG4105S7Z (LipO)protein G4273_RS23205 ENOG4107T0K Adenylate cyclase G4273_RS23215 ENOG41076E6 Uroporphyrinogen-III Synthase G4273_RS23220 ENOG4105ECF c-methyltransferase G4273_RS23225 ENOG410601J HemY protein G4273_RS23230 ENOG4105ENH Sulfatase G4273_RS23235 ENOG4105C4X radical SAM domain protein G4273_RS23260 ENOG4105C85 amino acid G4273_RS23280 ENOG4105EGZ biosynthesis protein G4273_RS23285 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G4273_RS23290 ENOG4108WJ1 acetyltransferase G4273_RS23295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G4273_RS23300 ENOG4105C1B dTDP-glucose 4-6-dehydratase G4273_RS23305 ENOG4107QQG Dehydrogenase G4273_RS23310 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G4273_RS23315 ENOG4105SFE lipopolysaccharide biosynthesis protein G4273_RS23320 ENOG4105ESV Glycosyl transferase, family 4 G4273_RS23325 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G4273_RS23350 ENOG4105C4R Atp-dependent dna helicase G4273_RS23355 ENOG4105KQ5 peptidylprolyl cis-trans isomerase G4273_RS23365 ENOG4105EMY transcriptional regulator G4273_RS23370 ENOG4105C7B Threonine dehydratase G4273_RS23375 ENOG4105C01 Dihydroxy-acid dehydratase G4273_RS23380 ENOG4105CM2 brancheD-chain amino acid aminotransferase G4273_RS23385 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit G4273_RS23405 ENOG4105C0P Mg chelatase subunit ChlI G4273_RS23410 ENOG4108WFC UPF0438 protein yifE G4273_RS23450 ENOG4107EJG GntR family transcriptional regulator G4273_RS23455 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4273_RS23460 ENOG4105ETE Transcriptional regulator (LacI family G4273_RS23465 ENOG4108RVA ribokinase G4273_RS23470 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G4273_RS23475 ENOG4105CNN ABC, transporter G4273_RS23480 ENOG4105C2J ABC transporter G4273_RS23510 ENOG4108VVK transcriptional Regulator, AsnC G4273_RS23515 ENOG4105QTB Flavodoxin G4273_RS23530 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation G4273_RS23575 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G4273_RS23580 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G4273_RS23585 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G4273_RS23590 ENOG4105C8U phosphate abc transporter G4273_RS23595 ENOG4105E2Z phosphate ABC transporter (Permease G4273_RS23600 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G4273_RS23605 ENOG4108UTW Plays a role in the regulation of phosphate uptake G4273_RS23610 ENOG4105CID antiterminator G4273_RS23615 ENOG4105C5Y PTS System G4273_RS23620 ENOG4105CS2 ec 3.2.1.21 G4273_RS23625 ENOG4108P68 Outer membrane porin G4273_RS23630 ENOG4105DYC esterase G4273_RS23635 ENOG4107VKM 6-phosphogluconolactonase G4273_RS23645 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 G4273_RS23650 ENOG4105C7N Xanthine uracil vitamin C permease G4273_RS23655 ENOG4108YYH Nadph-dependent fmn reductase G4273_RS23660 ENOG4105E8Q phosphopantetheinyl transferase G4273_RS23670 ENOG4105CNH Multidrug resistance protein MdtL G4273_RS23675 ENOG4108P6C Tryptophan transporter of low affinity G4273_RS23710 ENOG4105VG0 50S ribosomal protein l34 G4273_RS23725 ENOG4106CQM replication G4273_RS23820 ENOG41073YN Protein of unknown function (DUF1380) G4273_RS23825 ENOG4106JQ7 G4273_RS23875 ENOG4105FEQ ParB domain protein nuclease G4273_RS24140 ENOG4107U2T alpha beta G4273_RS24145 ENOG4107CBI conjugal transfer fertility inhibition protein G4273_RS24155 ENOG4105KK6 nuclease G4273_RS24170 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity)