locus-tag	class	description
G4273_RS00010	COG0592	DNA-directed DNA polymerase activity
G4273_RS00020	COG0187	DNA topoisomerase II activity
G4273_RS00025	COG3753	Protein conserved in bacteria
G4273_RS00030	COG0561	phosphatase activity
G4273_RS00040	COG2186	Transcriptional regulator
G4273_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
G4273_RS00050	COG0800	Aldolase
G4273_RS00060	COG2271	Major facilitator Superfamily
G4273_RS00065	COG0644	oxidoreductase
G4273_RS00070	COG0823	Involved in the tonB-independent uptake of proteins
G4273_RS00075	COG5645	(Lipo)protein
G4273_RS00095	COG2207	Transcriptional regulator
G4273_RS00100	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4273_RS00105	COG3119	arylsulfatase activity
G4273_RS00110	COG2149	membrane
G4273_RS00120	COG0641	radical SAM
G4273_RS00125	COG2814	Major facilitator Superfamily
G4273_RS00135	COG0028	Belongs to the TPP enzyme family
G4273_RS00140	COG0440	acetolactate synthase activity
G4273_RS00145	COG2197	response regulator
G4273_RS00150	COG3851	Histidine kinase
G4273_RS00155	COG2271	Major facilitator Superfamily
G4273_RS00160	COG2271	Major facilitator Superfamily
G4273_RS00170	COG2252	PERMEase
G4273_RS00200	COG1464	Belongs to the NlpA lipoprotein family
G4273_RS00205	COG0697	spore germination
G4273_RS00225	COG2211	Major facilitator Superfamily
G4273_RS00230	COG1501	Belongs to the glycosyl hydrolase 31 family
G4273_RS00235	COG3711	transcriptional antiterminator
G4273_RS00240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS00240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS00240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS00245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS00250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS00250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS00260	COG0191	fructose-bisphosphate aldolase activity
G4273_RS00265	COG1940	carbohydrate kinase activity
G4273_RS00275	COG2982	Protein involved in outer membrane biogenesis
G4273_RS00280	COG2233	PERMEase
G4273_RS00285	COG0786	glutamate:sodium symporter activity
G4273_RS00290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4273_RS00295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4273_RS00300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4273_RS00310	COG0194	GDP metabolic process
G4273_RS00320	COG2860	membrane
G4273_RS00325	COG3645	SOS response
G4273_RS00330	COG1561	YicC-like family, N-terminal region
G4273_RS00355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4273_RS00385	COG1519	Transferase
G4273_RS00390	COG0859	PFAM glycosyl transferase family 9
G4273_RS00395	COG0438	transferase activity, transferring glycosyl groups
G4273_RS00400	COG0515	serine threonine protein kinase
G4273_RS00415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G4273_RS00420	COG1442	glycosyl transferase family 8
G4273_RS00425	COG1216	Glycosyl transferase, family 2
G4273_RS00430	COG3307	-O-antigen
G4273_RS00435	COG0859	PFAM glycosyl transferase family 9
G4273_RS00440	COG0859	PFAM glycosyl transferase family 9
G4273_RS00450	COG0156	8-amino-7-oxononanoate synthase activity
G4273_RS00460	COG1216	Glycosyl transferase, family 2
G4273_RS00465	COG2861	carbohydrate metabolic process
G4273_RS00470	COG4942	peptidase
G4273_RS00480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4273_RS00485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4273_RS00500	COG1045	serine acetyltransferase
G4273_RS00505	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4273_RS00515	COG2186	Transcriptional regulator
G4273_RS00520	COG1620	l-lactate permease
G4273_RS00525	COG5295	Hep Hag repeat protein
G4273_RS00545	COG3722	fumarate hydratase activity
G4273_RS00555	COG2213	PTS system mannitol-specific
G4273_RS00555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS00565	COG1566	PFAM secretion protein HlyD family protein
G4273_RS00570	COG0625	glutathione transferase activity
G4273_RS00580	COG3276	selenocysteine insertion sequence binding
G4273_RS00585	COG1454	alcohol dehydrogenase
G4273_RS00595	COG1012	belongs to the aldehyde dehydrogenase family
G4273_RS00600	COG0235	Class ii aldolase
G4273_RS00605	COG3623	hexulose-6-phosphate isomerase
G4273_RS00610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
G4273_RS00615	COG1070	Carbohydrate kinase
G4273_RS00620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G4273_RS00625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G4273_RS00630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G4273_RS00640	COG2731	YhcH YjgK YiaL family protein
G4273_RS00650	COG1414	Transcriptional regulator
G4273_RS00655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS00660	COG3977	Valine--pyruvate aminotransferase
G4273_RS00665	COG0366	Alpha amylase catalytic
G4273_RS00670	COG2992	FlgJ-related protein
G4273_RS00675	COG1609	Transcriptional regulator
G4273_RS00675	COG2207	Transcriptional regulator
G4273_RS00680	COG4214	carbohydrate transport
G4273_RS00690	COG4213	ABC transporter substrate-binding protein
G4273_RS00700	COG1070	Carbohydrate kinase
G4273_RS00705	COG4682	membrane
G4273_RS00710	COG4682	membrane
G4273_RS00715	COG3274	enterobacterial common antigen metabolic process
G4273_RS00740	COG1278	Cold shock
G4273_RS00745	COG2944	sequence-specific DNA binding
G4273_RS00760	COG2885	chlorophyll binding
G4273_RS00765	COG0243	molybdopterin cofactor binding
G4273_RS00770	COG0456	acetyltransferase
G4273_RS00775	COG2818	Glycosylase
G4273_RS00780	COG5571	outer membrane autotransporter
G4273_RS00785	COG2223	nitrite transmembrane transporter activity
G4273_RS00790	COG2194	sulfuric ester hydrolase activity
G4273_RS00800	COG0747	negative chemotaxis
G4273_RS00805	COG0601	transmembrane transport
G4273_RS00810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4273_RS00815	COG0444	Belongs to the ABC transporter superfamily
G4273_RS00820	COG4608	Belongs to the ABC transporter superfamily
G4273_RS00825	COG0814	amino acid
G4273_RS00840	COG2194	sulfuric ester hydrolase activity
G4273_RS00865	COG1215	transferase activity, transferring glycosyl groups
G4273_RS00870	COG1215	transferase activity, transferring glycosyl groups
G4273_RS00875	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
G4273_RS00880	COG0457	Tetratricopeptide repeat
G4273_RS00880	COG3118	belongs to the thioredoxin family
G4273_RS00885	COG2199	diguanylate cyclase activity
G4273_RS00885	COG2200	EAL domain
G4273_RS00895	COG0612	Peptidase, M16
G4273_RS00900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS00905	COG2200	EAL domain
G4273_RS00910	COG2982	Protein involved in outer membrane biogenesis
G4273_RS00915	COG0477	Major facilitator Superfamily
G4273_RS00920	COG1295	ribonuclease BN
G4273_RS00925	COG0583	DNA-binding transcription factor activity
G4273_RS00930	COG2197	response regulator
G4273_RS00940	COG1858	cytochrome C peroxidase
G4273_RS00945	COG0076	glutamate decarboxylase activity
G4273_RS00955	COG2207	Transcriptional regulator
G4273_RS00960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4273_RS00965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4273_RS00975	COG2771	luxR family
G4273_RS00980	COG3247	response to pH
G4273_RS00995	COG1285	pathogenesis
G4273_RS01005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4273_RS01015	COG3721	Heme iron utilization protein
G4273_RS01030	COG4771	TonB-dependent receptor
G4273_RS01035	COG3720	iron ion transport
G4273_RS01040	COG2197	response regulator
G4273_RS01045	COG3065	identical protein binding
G4273_RS01055	COG1393	Belongs to the ArsC family
G4273_RS01065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4273_RS01070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G4273_RS01075	COG0339	signal peptide processing
G4273_RS01085	COG3104	oligopeptide transport
G4273_RS01090	COG0589	response to stress
G4273_RS01100	COG0306	phosphate transporter
G4273_RS01105	COG2081	HI0933 family
G4273_RS01115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4273_RS01120	COG1129	ABC transporter
G4273_RS01120	COG0842	Transport permease protein
G4273_RS01125	COG0842	Transport permease protein
G4273_RS01130	COG0191	fructose-bisphosphate aldolase activity
G4273_RS01145	COG3775	system Galactitol-specific IIC component
G4273_RS01150	COG3414	Phosphotransferase system galactitol-specific IIB component
G4273_RS01160	COG2188	Transcriptional regulator
G4273_RS01175	COG0444	Belongs to the ABC transporter superfamily
G4273_RS01180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4273_RS01185	COG0601	transmembrane transport
G4273_RS01190	COG0747	negative chemotaxis
G4273_RS01195	COG2091	lysine biosynthetic process via aminoadipic acid
G4273_RS01200	COG0628	permease
G4273_RS01205	COG0477	Major facilitator Superfamily
G4273_RS01215	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G4273_RS01230	COG3714	YhhN family
G4273_RS01240	COG3776	membrane
G4273_RS01245	COG0742	ribosomal rna small subunit methyltransferase
G4273_RS01250	COG0552	protein localization to endoplasmic reticulum
G4273_RS01255	COG2884	Cell division ATP-binding protein ftsE
G4273_RS01260	COG2177	Part of the ABC transporter FtsEX involved in
G4273_RS01265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4273_RS01270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4273_RS01275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4273_RS01300	COG0683	leucine binding
G4273_RS01305	COG0456	acetyltransferase
G4273_RS01310	COG0683	leucine binding
G4273_RS01315	COG0559	Belongs to the binding-protein-dependent transport system permease family
G4273_RS01320	COG4177	L-phenylalanine transmembrane transporter activity
G4273_RS01325	COG0411	ABC transporter
G4273_RS01330	COG0410	ABC transporter
G4273_RS01355	COG0584	glycerophosphoryl diester phosphodiesterase
G4273_RS01365	COG0405	Gamma-glutamyltransferase
G4273_RS01385	COG3157	Type VI secretion system effector, Hcp
G4273_RS01390	COG1247	-acetyltransferase
G4273_RS01395	COG0673	inositol 2-dehydrogenase activity
G4273_RS01400	COG1741	Belongs to the pirin family
G4273_RS01405	COG1609	Transcriptional regulator
G4273_RS01410	COG3265	gluconokinase activity
G4273_RS01415	COG2610	gluconate transmembrane transporter activity
G4273_RS01420	COG2095	MarC family integral membrane protein
G4273_RS01425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4273_RS01450	COG0058	SHG alpha-glucan phosphorylase activity
G4273_RS01460	COG3121	Chaperone
G4273_RS01465	COG3188	usher protein
G4273_RS01505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4273_RS01520	COG1349	DNA-binding transcription factor activity
G4273_RS01525	COG4650	regulator
G4273_RS01530	COG1690	Belongs to the RtcB family
G4273_RS01545	COG0058	SHG alpha-glucan phosphorylase activity
G4273_RS01550	COG1640	4-alpha-glucanotransferase
G4273_RS01555	COG2610	gluconate transmembrane transporter activity
G4273_RS01570	COG0596	Alpha beta hydrolase
G4273_RS01585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G4273_RS01590	COG1918	ferrous iron import across plasma membrane
G4273_RS01595	COG2183	response to ionizing radiation
G4273_RS01600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4273_RS01605	COG0745	RESPONSE REGULATOR receiver
G4273_RS01610	COG2205	protein histidine kinase activity
G4273_RS01620	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
G4273_RS01630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4273_RS01635	COG1011	Hydrolase
G4273_RS01645	COG0494	nUDIX hydrolase
G4273_RS01650	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G4273_RS01655	COG4972	Pilus assembly protein
G4273_RS01660	COG3166	PFAM Fimbrial assembly family protein
G4273_RS01675	COG4796	Type ii and iii secretion system protein
G4273_RS01690	COG3266	domain, Protein
G4273_RS01695	COG0338	D12 class N6 adenine-specific DNA methyltransferase
G4273_RS01700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4273_RS01710	COG0180	Tryptophanyl-tRNA synthetase
G4273_RS01715	COG2188	Transcriptional regulator
G4273_RS01725	COG3457	Alanine racemase
G4273_RS01730	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G4273_RS01735	COG1735	metal-dependent hydrolase with the TIM-barrel fold
G4273_RS01750	COG0626	cystathionine gamma-synthase activity
G4273_RS01765	COG2116	formate transmembrane transporter activity
G4273_RS01770	COG2146	nitrite reductase [NAD(P)H] activity
G4273_RS01775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4273_RS01785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4273_RS01795	COG2184	nucleotidyltransferase activity
G4273_RS01800	COG0512	Glutamine amidotransferase of anthranilate synthase
G4273_RS01805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4273_RS01810	COG1289	transmembrane transporter activity
G4273_RS01815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4273_RS01820	COG1765	OsmC-like protein
G4273_RS01825	COG3954	Phosphoribulokinase
G4273_RS01835	COG0429	hydrolase of the alpha beta-hydrolase fold
G4273_RS01840	COG0488	(ABC) transporter
G4273_RS01855	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
G4273_RS01860	COG1047	Peptidyl-prolyl cis-trans
G4273_RS01870	COG0545	Peptidyl-prolyl cis-trans isomerase
G4273_RS01875	COG2964	Protein conserved in bacteria
G4273_RS01915	COG3979	chitinase
G4273_RS01920	COG2906	2 iron, 2 sulfur cluster binding
G4273_RS01925	COG2193	ferroxidase activity
G4273_RS01930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G4273_RS01935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
G4273_RS01940	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
G4273_RS01945	COG3156	type II secretion system protein K
G4273_RS01950	COG4795	General secretion pathway protein
G4273_RS01955	COG2165	general secretion pathway protein
G4273_RS01960	COG2165	general secretion pathway protein
G4273_RS01965	COG2165	general secretion pathway protein
G4273_RS01970	COG1459	type II secretion system
G4273_RS01975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4273_RS01980	COG1450	Type ii and iii secretion system protein
G4273_RS01985	COG3031	protein transport across the cell outer membrane
G4273_RS01990	COG3267	Type II secretory pathway component ExeA
G4273_RS01990	COG3409	Peptidoglycan-binding domain 1 protein
G4273_RS02015	COG0089	rRNA binding
G4273_RS02105	COG0201	protein transport
G4273_RS02145	COG0789	Transcriptional regulator
G4273_RS02150	COG3036	rescue of stalled ribosome
G4273_RS02160	COG0569	domain protein
G4273_RS02165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4273_RS02165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4273_RS02170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4273_RS02180	COG0758	DNA mediated transformation
G4273_RS02190	COG0551	DNA topoisomerase type I activity
G4273_RS02195	COG0009	L-threonylcarbamoyladenylate synthase
G4273_RS02210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4273_RS02250	COG1126	abc transporter atp-binding protein
G4273_RS02255	COG0765	amino acid transport
G4273_RS02260	COG4597	amino acid ABC transporter
G4273_RS02265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4273_RS02275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4273_RS02280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4273_RS02285	COG1309	transcriptional regulator
G4273_RS02295	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G4273_RS02305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4273_RS02315	COG4145	pantothenate transmembrane transporter activity
G4273_RS02320	COG3924	membrane
G4273_RS02325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS02330	COG1349	DNA-binding transcription factor activity
G4273_RS02340	COG1879	ABC-type sugar transport system periplasmic component
G4273_RS02345	COG1129	ABC transporter
G4273_RS02350	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4273_RS02355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS02365	COG0439	Biotin carboxylase
G4273_RS02370	COG0511	ligase activity, forming carbon-carbon bonds
G4273_RS02380	COG0604	alcohol dehydrogenase
G4273_RS02385	COG2200	EAL domain
G4273_RS02385	COG2199	diguanylate cyclase activity
G4273_RS02390	COG1077	Cell shape determining protein MreB Mrl
G4273_RS02395	COG1792	Involved in formation and maintenance of cell shape
G4273_RS02400	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G4273_RS02410	COG1530	ribonuclease E activity
G4273_RS02415	COG3164	Protein of unknown function
G4273_RS02420	COG0312	modulator of DNA gyrase
G4273_RS02425	COG0583	DNA-binding transcription factor activity
G4273_RS02445	COG2732	(Barnase) inhibitor
G4273_RS02465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4273_RS02470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4273_RS02475	COG3105	Protein conserved in bacteria
G4273_RS02480	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G4273_RS02495	COG0625	glutathione transferase activity
G4273_RS02500	COG2969	positive regulation of protein catabolic process
G4273_RS02515	COG2814	Major facilitator Superfamily
G4273_RS02530	COG2731	YhcH YjgK YiaL family protein
G4273_RS02535	COG4804	nuclease activity
G4273_RS02540	COG0493	'glutamate synthase
G4273_RS02545	COG0070	glutamate synthase
G4273_RS02545	COG0067	glutamate synthase
G4273_RS02545	COG0069	glutamate synthase activity
G4273_RS02550	COG1242	4 iron, 4 sulfur cluster binding
G4273_RS02555	COG2198	Histidine kinase
G4273_RS02555	COG5002	protein histidine kinase activity
G4273_RS02555	COG0784	Response regulator, receiver
G4273_RS02560	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
G4273_RS02575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS02590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4273_RS02595	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G4273_RS02600	COG1137	ATPase activity
G4273_RS02605	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G4273_RS02610	COG3117	lipopolysaccharide transmembrane transporter activity
G4273_RS02615	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G4273_RS02620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G4273_RS02620	COG0517	IMP dehydrogenase activity
G4273_RS02625	COG0530	calcium, potassium:sodium antiporter activity
G4273_RS02630	COG1127	ABC transporter
G4273_RS02635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4273_RS02640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4273_RS02645	COG2854	intermembrane phospholipid transfer
G4273_RS02650	COG3113	response to antibiotic
G4273_RS02655	COG5007	Belongs to the BolA IbaG family
G4273_RS02665	COG3423	Transcriptional regulator
G4273_RS02670	COG0142	geranyltranstransferase activity
G4273_RS02685	COG0697	spore germination
G4273_RS02695	COG2027	D-alanyl-D-alanine carboxypeptidase
G4273_RS02700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4273_RS02705	COG1534	Rna-binding protein
G4273_RS02715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4273_RS02720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4273_RS02730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4273_RS02740	COG2194	sulfuric ester hydrolase activity
G4273_RS02760	COG0195	Participates in both transcription termination and antitermination
G4273_RS02800	COG0513	Belongs to the DEAD box helicase family
G4273_RS02805	COG0814	amino acid
G4273_RS02810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4273_RS02815	COG0826	peptidase U32
G4273_RS02820	COG0826	peptidase U32
G4273_RS02825	COG3154	lipid carrier protein
G4273_RS02830	COG3153	acetyltransferase
G4273_RS02845	COG0693	protein deglycase activity
G4273_RS02850	COG0702	epimerase
G4273_RS02855	COG0701	Predicted permease
G4273_RS02860	COG2823	Periplasmic or secreted lipoprotein
G4273_RS02880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G4273_RS02885	COG0363	glucosamine-6-phosphate deaminase activity
G4273_RS02890	COG3716	PTS system mannose fructose sorbose family IID component
G4273_RS02895	COG3715	PTS system
G4273_RS02900	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS02910	COG2222	sugar isomerase
G4273_RS02915	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4273_RS02920	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS02925	COG3716	PTS system mannose fructose sorbose family IID component
G4273_RS02935	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS02945	COG1349	DNA-binding transcription factor activity
G4273_RS02950	COG2721	sulfolactate sulfo-lyase activity
G4273_RS02955	COG2271	Major facilitator Superfamily
G4273_RS02965	COG2084	Dehydrogenase
G4273_RS02970	COG1929	Belongs to the glycerate kinase type-1 family
G4273_RS02985	COG0583	DNA-binding transcription factor activity
G4273_RS02990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4273_RS03000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4273_RS03005	COG1882	Formate acetyltransferase
G4273_RS03010	COG0251	oxidation-reduction process
G4273_RS03015	COG1760	l-serine dehydratase
G4273_RS03020	COG0814	amino acid
G4273_RS03035	COG1741	Belongs to the pirin family
G4273_RS03040	COG0583	DNA-binding transcription factor activity
G4273_RS03045	COG3152	Membrane
G4273_RS03050	COG0435	Glutathione S-transferase
G4273_RS03055	COG2259	Doxx family
G4273_RS03065	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
G4273_RS03070	COG4575	ribosome binding
G4273_RS03075	COG1422	Protein of unknown function (DUF1090)
G4273_RS03085	COG0586	Pfam SNARE associated Golgi protein
G4273_RS03090	COG2186	Transcriptional regulator
G4273_RS03095	COG2271	Major facilitator Superfamily
G4273_RS03105	COG2721	sulfolactate sulfo-lyase activity
G4273_RS03120	COG0861	Integral membrane protein TerC family
G4273_RS03125	COG0673	inositol 2-dehydrogenase activity
G4273_RS03130	COG2949	membrane
G4273_RS03135	COG1451	nucleotide metabolic process
G4273_RS03150	COG5499	transcription regulator containing HTH domain
G4273_RS03155	COG1902	pentaerythritol trinitrate reductase activity
G4273_RS03155	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4273_RS03160	COG3408	Glycogen debranching enzyme
G4273_RS03160	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
G4273_RS03170	COG0531	amino acid
G4273_RS03175	COG2731	YhcH YjgK YiaL family protein
G4273_RS03180	COG3250	beta-galactosidase activity
G4273_RS03185	COG1609	Transcriptional regulator
G4273_RS03190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4273_RS03200	COG0840	transmembrane signaling receptor activity
G4273_RS03205	COG1695	Transcriptional regulator
G4273_RS03210	COG2375	cellular response to nickel ion
G4273_RS03225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4273_RS03230	COG0358	DNA primase activity
G4273_RS03235	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G4273_RS03245	COG0471	metal ion transport
G4273_RS03250	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4273_RS03270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4273_RS03280	COG0617	tRNA 3'-terminal CCA addition
G4273_RS03285	COG4991	sh3 domain protein
G4273_RS03290	COG0675	Transposase, IS605 OrfB family
G4273_RS03300	COG3025	triphosphatase activity
G4273_RS03305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G4273_RS03320	COG2268	Band 7 protein
G4273_RS03325	COG1585	Membrane protein implicated in regulation of membrane protease activity
G4273_RS03345	COG3539	Fimbrial protein
G4273_RS03350	COG3121	Chaperone
G4273_RS03355	COG3188	usher protein
G4273_RS03360	COG3539	Fimbrial protein
G4273_RS03375	COG3384	dioxygenase
G4273_RS03385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G4273_RS03395	COG0754	glutathionylspermidine amidase activity
G4273_RS03405	COG1538	Outer membrane efflux protein
G4273_RS03410	COG0494	nUDIX hydrolase
G4273_RS03415	COG3151	Protein conserved in bacteria
G4273_RS03420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4273_RS03425	COG3150	esterase
G4273_RS03430	COG0187	DNA topoisomerase II activity
G4273_RS03435	COG4774	siderophore transport
G4273_RS03440	COG1120	ATPase activity
G4273_RS03445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4273_RS03450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4273_RS03460	COG1737	Transcriptional regulator
G4273_RS03465	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
G4273_RS03470	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4273_RS03485	COG0642	Histidine kinase
G4273_RS03490	COG0745	RESPONSE REGULATOR receiver
G4273_RS03495	COG3111	PFAM Bacterial OB fold (BOF) protein
G4273_RS03500	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
G4273_RS03505	COG4166	transmembrane transport
G4273_RS03510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4273_RS03515	COG0204	Acyl-transferase
G4273_RS03520	COG2132	Multicopper oxidase
G4273_RS03540	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4273_RS03545	COG1063	alcohol dehydrogenase
G4273_RS03550	COG0246	Mannitol dehydrogenase
G4273_RS03555	COG2186	Transcriptional regulator
G4273_RS03565	COG4238	major outer membrane lipoprotein
G4273_RS03575	COG0656	L-ascorbic acid biosynthetic process
G4273_RS03580	COG1979	alcohol dehydrogenase
G4273_RS03585	COG2207	Transcriptional regulator
G4273_RS03590	COG0586	Pfam SNARE associated Golgi protein
G4273_RS03595	COG0626	cystathionine gamma-synthase activity
G4273_RS03600	COG0811	peptide transport
G4273_RS03605	COG0848	biopolymer transport protein
G4273_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS03620	COG0667	Aldo Keto reductase
G4273_RS03635	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G4273_RS03640	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS03645	COG5557	Pfam Polysulphide reductase, NrfD
G4273_RS03650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G4273_RS03655	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4273_RS03660	COG1773	rubredoxin
G4273_RS03665	COG0375	protein maturation
G4273_RS03670	COG0298	carbon dioxide binding
G4273_RS03675	COG0625	glutathione transferase activity
G4273_RS03680	COG0754	glutathionylspermidine amidase activity
G4273_RS03685	COG0306	phosphate transporter
G4273_RS03690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4273_RS03695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4273_RS03700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4273_RS03705	COG2244	polysaccharide biosynthetic process
G4273_RS03715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
G4273_RS03720	COG0795	lipopolysaccharide-transporting ATPase activity
G4273_RS03730	COG0156	8-amino-7-oxononanoate synthase activity
G4273_RS03735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4273_RS03745	COG0318	PFAM AMP-dependent synthetase and ligase
G4273_RS03750	COG0456	acetyltransferase
G4273_RS03755	COG2186	Transcriptional regulator
G4273_RS03760	COG0277	FAD linked oxidase domain protein
G4273_RS03765	COG0277	FAD linked oxidase domain protein
G4273_RS03770	COG0247	lactate metabolic process
G4273_RS03775	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G4273_RS03785	COG1620	l-lactate permease
G4273_RS03790	COG3064	Membrane
G4273_RS03795	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G4273_RS03815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4273_RS03820	COG1459	type II secretion system
G4273_RS03825	COG2165	general secretion pathway protein
G4273_RS03840	COG4795	General secretion pathway protein
G4273_RS03855	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
G4273_RS03945	COG1484	DNA-dependent DNA replication
G4273_RS03950	COG4584	PFAM Integrase catalytic
G4273_RS04000	COG2003	Belongs to the UPF0758 family
G4273_RS04025	COG2020	methyltransferase activity
G4273_RS04030	COG2433	Pfam Transposase IS66
G4273_RS04045	COG3468	outer membrane autotransporter barrel domain protein
G4273_RS04055	COG4983	Phage plasmid primase, P4 family domain protein
G4273_RS04090	COG4372	Transposase
G4273_RS04100	COG3436	PFAM IS66 Orf2 family protein
G4273_RS04115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4273_RS04120	COG1940	carbohydrate kinase activity
G4273_RS04125	COG2814	Major facilitator Superfamily
G4273_RS04135	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G4273_RS04140	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
G4273_RS04145	COG2755	lipolytic protein G-D-S-L family
G4273_RS04145	COG0657	acetylesterase activity
G4273_RS04205	COG4771	TonB-dependent receptor
G4273_RS04340	COG3436	PFAM IS66 Orf2 family protein
G4273_RS04360	COG2274	protein secretion by the type I secretion system
G4273_RS04380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4273_RS04390	COG0745	RESPONSE REGULATOR receiver
G4273_RS04395	COG5002	protein histidine kinase activity
G4273_RS04410	COG3436	PFAM IS66 Orf2 family protein
G4273_RS04430	COG0582	viral genome integration into host DNA
G4273_RS04440	COG1811	Na channel or pump
G4273_RS04445	COG1982	Orn Lys Arg decarboxylase major
G4273_RS04450	COG2211	Major facilitator Superfamily
G4273_RS04465	COG1194	a g-specific adenine glycosylase
G4273_RS04475	COG3171	Protein conserved in bacteria
G4273_RS04490	COG0252	asparaginase activity
G4273_RS04505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4273_RS04510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4273_RS04520	COG0762	integral membrane protein
G4273_RS04525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G4273_RS04530	COG2805	Type II/IV secretion system protein
G4273_RS04545	COG0189	ligase activity
G4273_RS04550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4273_RS04555	COG2356	endonuclease I
G4273_RS04565	COG2814	Major facilitator Superfamily
G4273_RS04585	COG1166	arginine decarboxylase activity
G4273_RS04600	COG0501	Belongs to the peptidase M48B family
G4273_RS04605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4273_RS04610	COG0330	HflC and HflK could
G4273_RS04615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS04620	COG2213	PTS system mannitol-specific
G4273_RS04625	COG1063	alcohol dehydrogenase
G4273_RS04630	COG1494	fructose-1,6-bisphosphatase
G4273_RS04640	COG1072	(Pantothenic acid kinase))
G4273_RS04645	COG1122	ATPase activity
G4273_RS04680	COG0191	fructose-bisphosphate aldolase activity
G4273_RS04685	COG0668	transmembrane transport
G4273_RS04690	COG1279	arginine transmembrane transporter activity
G4273_RS04695	COG2968	Membrane
G4273_RS04705	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4273_RS04705	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4273_RS04725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4273_RS04735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4273_RS04755	COG0006	proline dipeptidase activity
G4273_RS04760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4273_RS04765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4273_RS04775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G4273_RS04790	COG2723	6-phospho-beta-galactosidase activity
G4273_RS04800	COG1272	protein, Hemolysin III
G4273_RS04810	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G4273_RS04820	COG0716	FMN binding
G4273_RS04825	COG4974	Belongs to the 'phage' integrase family
G4273_RS04830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4273_RS04835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4273_RS04845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4273_RS04865	COG2233	PERMEase
G4273_RS04875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS04880	COG2252	PERMEase
G4273_RS04885	COG0402	S-adenosylhomocysteine deaminase activity
G4273_RS04890	COG2233	PERMEase
G4273_RS04895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4273_RS04895	COG2080	2 iron, 2 sulfur cluster binding
G4273_RS04900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4273_RS04905	COG0402	S-adenosylhomocysteine deaminase activity
G4273_RS04910	COG0493	'glutamate synthase
G4273_RS04910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS04915	COG2068	MobA-Related Protein
G4273_RS04920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4273_RS04925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G4273_RS04925	COG3608	succinylglutamate desuccinylase aspartoacylase
G4273_RS04930	COG0549	Belongs to the carbamate kinase family
G4273_RS04940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4273_RS04945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4273_RS04950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4273_RS04960	COG2080	2 iron, 2 sulfur cluster binding
G4273_RS04965	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G4273_RS04970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4273_RS04975	COG4942	peptidase
G4273_RS04985	COG0814	amino acid
G4273_RS04990	COG0183	Belongs to the thiolase family
G4273_RS05000	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS05005	COG2814	Major facilitator Superfamily
G4273_RS05010	COG1794	racemase activity, acting on amino acids and derivatives
G4273_RS05015	COG0583	DNA-binding transcription factor activity
G4273_RS05025	COG1609	Transcriptional regulator
G4273_RS05040	COG0667	Aldo Keto reductase
G4273_RS05050	COG0861	Integral membrane protein TerC family
G4273_RS05065	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
G4273_RS05080	COG2165	general secretion pathway protein
G4273_RS05085	COG4795	General secretion pathway protein
G4273_RS05095	COG4967	type IV pilus modification protein PilV
G4273_RS05100	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G4273_RS05105	COG1025	Belongs to the peptidase M16 family
G4273_RS05110	COG1074	ATP-dependent DNA helicase activity
G4273_RS05115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4273_RS05120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4273_RS05120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G4273_RS05125	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4273_RS05130	COG3711	transcriptional antiterminator
G4273_RS05135	COG1263	PTS System
G4273_RS05135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS05140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4273_RS05265	COG2885	chlorophyll binding
G4273_RS05305	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G4273_RS05310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4273_RS05315	COG2166	iron-sulfur cluster assembly
G4273_RS05320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4273_RS05330	COG0583	DNA-binding transcription factor activity
G4273_RS05335	COG2363	Small membrane protein
G4273_RS05345	COG1349	DNA-binding transcription factor activity
G4273_RS05355	COG1070	Carbohydrate kinase
G4273_RS05365	COG0738	Major facilitator superfamily
G4273_RS05370	COG0235	Class ii aldolase
G4273_RS05375	COG1454	alcohol dehydrogenase
G4273_RS05385	COG1760	l-serine dehydratase
G4273_RS05390	COG0814	amino acid
G4273_RS05395	COG1611	Belongs to the LOG family
G4273_RS05410	COG3098	single-species biofilm formation
G4273_RS05415	COG0564	pseudouridine synthase activity
G4273_RS05420	COG0716	FMN binding
G4273_RS05425	COG2271	Major facilitator Superfamily
G4273_RS05430	COG4948	Mandelate Racemase Muconate Lactonizing
G4273_RS05435	COG4948	Mandelate Racemase Muconate Lactonizing
G4273_RS05440	COG4999	Histidine kinase
G4273_RS05440	COG2205	protein histidine kinase activity
G4273_RS05440	COG3437	response regulator, receiver
G4273_RS05440	COG3850	Histidine kinase
G4273_RS05450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4273_RS05455	COG3956	TIGRFAM MazG family protein
G4273_RS05470	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G4273_RS05480	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G4273_RS05490	COG0602	queuosine metabolic process
G4273_RS05495	COG1070	Carbohydrate kinase
G4273_RS05500	COG2223	nitrite transmembrane transporter activity
G4273_RS05505	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS05510	COG0277	FAD linked oxidase domain protein
G4273_RS05515	COG0477	Major facilitator Superfamily
G4273_RS05520	COG2086	electron transfer activity
G4273_RS05525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4273_RS05530	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
G4273_RS05535	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G4273_RS05540	COG0644	oxidoreductase
G4273_RS05545	COG0720	synthase
G4273_RS05550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4273_RS05570	COG2234	aminopeptidase activity
G4273_RS05610	COG0585	pseudouridine synthase activity
G4273_RS05625	COG4942	peptidase
G4273_RS05625	COG1388	LysM domain
G4273_RS05630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4273_RS05645	COG2610	gluconate transmembrane transporter activity
G4273_RS05650	COG3622	Belongs to the hyi family
G4273_RS05655	COG0235	Class ii aldolase
G4273_RS05660	COG3395	kinase activity
G4273_RS05665	COG2084	Dehydrogenase
G4273_RS05670	COG1349	DNA-binding transcription factor activity
G4273_RS05675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4273_RS05685	COG0582	viral genome integration into host DNA
G4273_RS05735	COG3604	Transcriptional regulator
G4273_RS05740	COG0309	Hydrogenase expression formation protein (HypE)
G4273_RS05745	COG0409	Hydrogenase expression formation protein
G4273_RS05750	COG0298	carbon dioxide binding
G4273_RS05755	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G4273_RS05760	COG0375	protein maturation
G4273_RS05770	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS05775	COG0651	ATP synthesis coupled electron transport
G4273_RS05780	COG0650	Formate hydrogenlyase subunit 4
G4273_RS05785	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
G4273_RS05785	COG3261	NADH dehydrogenase
G4273_RS05790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4273_RS05795	COG3260	NADH ubiquinone oxidoreductase 20
G4273_RS05805	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4273_RS05815	COG4680	protein conserved in bacteria
G4273_RS05820	COG5499	transcription regulator containing HTH domain
G4273_RS05830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS05835	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
G4273_RS05855	COG0517	IMP dehydrogenase activity
G4273_RS05855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G4273_RS05860	COG1349	DNA-binding transcription factor activity
G4273_RS05865	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS05870	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS05880	COG3732	PTS system glucitol sorbitol-specific
G4273_RS05885	COG3730	PTS system glucitol sorbitol-specific
G4273_RS05890	COG2951	lytic endotransglycosylase activity
G4273_RS05895	COG1546	Belongs to the CinA family
G4273_RS05915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G4273_RS05945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4273_RS05950	COG1238	metal cluster binding
G4273_RS05975	COG2814	Major facilitator Superfamily
G4273_RS05980	COG1566	PFAM secretion protein HlyD family protein
G4273_RS05985	COG1846	Transcriptional regulator
G4273_RS05995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G4273_RS06000	COG2814	Major facilitator Superfamily
G4273_RS06005	COG2113	Glycine betaine
G4273_RS06010	COG4176	ABC-type proline glycine betaine transport system permease component
G4273_RS06015	COG4175	Glycine betaine
G4273_RS06020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4273_RS06025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4273_RS06035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4273_RS06040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4273_RS06050	COG4575	ribosome binding
G4273_RS06065	COG2916	Histone family protein nucleoid-structuring protein H-NS
G4273_RS06070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4273_RS06075	COG0640	Transcriptional regulator
G4273_RS06080	COG0401	homolog of Blt101
G4273_RS06085	COG1652	LysM domain
G4273_RS06090	COG1802	Transcriptional regulator
G4273_RS06095	COG1113	amino acid transport
G4273_RS06100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4273_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
G4273_RS06110	COG0579	oxidoreductase
G4273_RS06130	COG2867	negative regulation of translational initiation
G4273_RS06140	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4273_RS06145	COG0497	DNA recombination
G4273_RS06160	COG4536	flavin adenine dinucleotide binding
G4273_RS06165	COG4137	Cytochrome C assembly protein
G4273_RS06170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4273_RS06195	COG2885	chlorophyll binding
G4273_RS06200	COG2199	diguanylate cyclase activity
G4273_RS06215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4273_RS06220	COG0287	Prephenate dehydrogenase
G4273_RS06220	COG1605	Chorismate mutase
G4273_RS06225	COG1605	Chorismate mutase
G4273_RS06225	COG0077	Prephenate dehydratase
G4273_RS06235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4273_RS06240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4273_RS06245	COG0564	pseudouridine synthase activity
G4273_RS06255	COG0542	response to heat
G4273_RS06290	COG0477	Major facilitator Superfamily
G4273_RS06295	COG5544	Lipoprotein
G4273_RS06300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4273_RS06305	COG0045	succinate-CoA ligase (ADP-forming) activity
G4273_RS06305	COG1042	CoA-binding domain protein
G4273_RS06305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4273_RS06315	COG3118	belongs to the thioredoxin family
G4273_RS06320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4273_RS06340	COG0583	DNA-binding transcription factor activity
G4273_RS06345	COG0513	Belongs to the DEAD box helicase family
G4273_RS06355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G4273_RS06365	COG1595	DNA-templated transcription, initiation
G4273_RS06370	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
G4273_RS06375	COG3026	antisigma factor binding
G4273_RS06380	COG3086	response to oxidative stress
G4273_RS06390	COG0681	Belongs to the peptidase S26 family
G4273_RS06410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G4273_RS06425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS06430	COG1737	Transcriptional regulator
G4273_RS06435	COG0560	Phosphoserine phosphatase
G4273_RS06440	COG0590	tRNA wobble adenosine to inosine editing
G4273_RS06450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4273_RS06450	COG0047	phosphoribosylformylglycinamidine synthase activity
G4273_RS06455	COG2205	protein histidine kinase activity
G4273_RS06460	COG3170	Tfp pilus assembly protein FimV
G4273_RS06465	COG2204	response regulator
G4273_RS06470	COG0347	Belongs to the P(II) protein family
G4273_RS06475	COG1017	nitric oxide dioxygenase activity
G4273_RS06475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4273_RS06485	COG1940	carbohydrate kinase activity
G4273_RS06490	COG0457	Tetratricopeptide repeat
G4273_RS06495	COG1879	ABC-type sugar transport system periplasmic component
G4273_RS06500	COG1129	ABC transporter
G4273_RS06505	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4273_RS06510	COG1063	alcohol dehydrogenase
G4273_RS06515	COG2017	converts alpha-aldose to the beta-anomer
G4273_RS06520	COG2259	Doxx family
G4273_RS06525	COG2814	Major facilitator Superfamily
G4273_RS06530	COG3711	transcriptional antiterminator
G4273_RS06535	COG1073	alpha beta
G4273_RS06540	COG0483	inositol monophosphate 1-phosphatase activity
G4273_RS06560	COG0822	iron-sulfur transferase activity
G4273_RS06580	COG0633	Ferredoxin
G4273_RS06585	COG2975	iron-sulfur cluster assembly
G4273_RS06605	COG2897	thiosulfate sulfurtransferase activity
G4273_RS06610	COG2373	Large extracellular alpha-helical protein
G4273_RS06615	COG4953	penicillin-binding protein 1C
G4273_RS06645	COG2976	Protein conserved in bacteria
G4273_RS06660	COG1645	bacterial-type flagellum-dependent swarming motility
G4273_RS06685	COG0517	IMP dehydrogenase activity
G4273_RS06685	COG0516	GMP reductase activity
G4273_RS06715	COG3133	Outer membrane lipoprotein
G4273_RS06730	COG2200	EAL domain
G4273_RS06735	COG0248	Ppx GppA phosphatase
G4273_RS06740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G4273_RS06745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4273_RS06760	COG2233	PERMEase
G4273_RS06770	COG1393	Belongs to the ArsC family
G4273_RS06775	COG4783	chaperone-mediated protein folding
G4273_RS06780	COG0628	permease
G4273_RS06785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4273_RS06790	COG2716	regulation of RNA biosynthetic process
G4273_RS06800	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G4273_RS06810	COG2321	neutral zinc metallopeptidase
G4273_RS06820	COG0400	carboxylic ester hydrolase activity
G4273_RS06835	COG1393	Belongs to the ArsC family
G4273_RS06845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4273_RS06850	COG3850	Histidine kinase
G4273_RS06855	COG0493	'glutamate synthase
G4273_RS06855	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS06865	COG5342	invasion associated locus B
G4273_RS06870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4273_RS06875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4273_RS06880	COG0280	phosphate acetyltransferase
G4273_RS06880	COG0281	malic enzyme
G4273_RS06885	COG4810	utilization protein
G4273_RS06890	COG4917	ethanolamine utilization protein
G4273_RS06895	COG4766	ethanolamine catabolic process
G4273_RS06900	COG4812	Cobalamin adenosyltransferase
G4273_RS06905	COG0280	phosphate acetyltransferase
G4273_RS06910	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
G4273_RS06915	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
G4273_RS06920	COG1012	belongs to the aldehyde dehydrogenase family
G4273_RS06925	COG4820	ethanolamine utilization protein (EutJ)
G4273_RS06930	COG1454	alcohol dehydrogenase
G4273_RS06935	COG3192	ethanolamine utilization protein
G4273_RS06940	COG4819	ethanolamine utilization protein
G4273_RS06945	COG4303	Ethanolamine ammonia lyase large subunit
G4273_RS06955	COG4816	utilization protein
G4273_RS06960	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
G4273_RS06965	COG2207	Transcriptional regulator
G4273_RS06975	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4273_RS06995	COG2837	iron assimilation
G4273_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS07015	COG4150	thiosulfate binding
G4273_RS07020	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G4273_RS07025	COG4208	sulfate ABC transporter
G4273_RS07030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G4273_RS07035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4273_RS07050	COG2190	(PTS) system
G4273_RS07055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4273_RS07060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS07065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4273_RS07085	COG3530	Putative quorum-sensing-regulated virulence factor
G4273_RS07090	COG0385	Bile acid
G4273_RS07095	COG0583	DNA-binding transcription factor activity
G4273_RS07105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4273_RS07110	COG2211	Major facilitator Superfamily
G4273_RS07120	COG0583	DNA-binding transcription factor activity
G4273_RS07150	COG3415	Transposase
G4273_RS07155	COG3415	Transposase
G4273_RS07170	COG2199	diguanylate cyclase activity
G4273_RS07170	COG2200	EAL domain
G4273_RS07175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4273_RS07200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS07205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS07210	COG0006	proline dipeptidase activity
G4273_RS07215	COG1363	Peptidase, m42
G4273_RS07220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4273_RS07220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS07220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS07225	COG2207	Transcriptional regulator
G4273_RS07230	COG3279	Response regulator of the LytR AlgR family
G4273_RS07235	COG3275	phosphorelay sensor kinase activity
G4273_RS07240	COG0436	Aminotransferase
G4273_RS07250	COG1560	Kdo2-lipid A biosynthetic process
G4273_RS07275	COG0028	Belongs to the TPP enzyme family
G4273_RS07280	COG0679	Auxin Efflux Carrier
G4273_RS07285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4273_RS07290	COG0784	Response regulator, receiver
G4273_RS07290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4273_RS07290	COG2198	Histidine kinase
G4273_RS07290	COG2205	protein histidine kinase activity
G4273_RS07295	COG2197	response regulator
G4273_RS07300	COG1566	PFAM secretion protein HlyD family protein
G4273_RS07305	COG0477	Major facilitator Superfamily
G4273_RS07310	COG3048	D-serine ammonia-lyase activity
G4273_RS07315	COG2610	gluconate transmembrane transporter activity
G4273_RS07320	COG0583	DNA-binding transcription factor activity
G4273_RS07330	COG2116	formate transmembrane transporter activity
G4273_RS07340	COG2067	long-chain fatty acid transport protein
G4273_RS07345	COG3691	Protein conserved in bacteria
G4273_RS07360	COG2062	phosphohistidine phosphatase, SixA
G4273_RS07365	COG3539	Fimbrial protein
G4273_RS07370	COG3188	usher protein
G4273_RS07375	COG3121	Chaperone
G4273_RS07380	COG3539	Fimbrial protein
G4273_RS07385	COG3539	Fimbrial protein
G4273_RS07390	COG3539	Fimbrial protein
G4273_RS07420	COG0730	response to heat
G4273_RS07425	COG3101	peptidyl-lysine hydroxylation
G4273_RS07440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4273_RS07445	COG2814	Major facilitator Superfamily
G4273_RS07460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4273_RS07470	COG0586	Pfam SNARE associated Golgi protein
G4273_RS07480	COG0285	dihydrofolate synthase activity
G4273_RS07485	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
G4273_RS07490	COG1286	toxin biosynthetic process
G4273_RS07495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G4273_RS07500	COG0163	prenyltransferase activity
G4273_RS07505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4273_RS07510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4273_RS07515	COG4215	(ABC) transporter
G4273_RS07520	COG4160	amino acid transport
G4273_RS07525	COG4598	ABC transporter
G4273_RS07530	COG5464	transposase or invertase
G4273_RS07535	COG1090	epimerase
G4273_RS07540	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4273_RS07545	COG0625	glutathione transferase activity
G4273_RS07550	COG0625	glutathione transferase activity
G4273_RS07555	COG0622	Phosphoesterase
G4273_RS07560	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G4273_RS07565	COG1288	antiporter activity
G4273_RS07570	COG0857	belongs to the CobB CobQ family
G4273_RS07570	COG0280	phosphate acetyltransferase
G4273_RS07575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4273_RS07590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4273_RS07595	COG0471	metal ion transport
G4273_RS07595	COG0490	domain, Protein
G4273_RS07605	COG0436	Aminotransferase
G4273_RS07610	COG0583	DNA-binding transcription factor activity
G4273_RS07630	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G4273_RS07635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G4273_RS07640	COG1034	ATP synthesis coupled electron transport
G4273_RS07655	COG0839	Belongs to the complex I subunit 6 family
G4273_RS07665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4273_RS07670	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4273_RS07685	COG2234	aminopeptidase activity
G4273_RS07690	COG2304	oxidoreductase activity
G4273_RS07700	COG2153	protein acetylation
G4273_RS07705	COG4575	ribosome binding
G4273_RS07710	COG1169	isochorismate synthase
G4273_RS07725	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G4273_RS07730	COG1441	menaquinone biosynthetic process
G4273_RS07735	COG0318	PFAM AMP-dependent synthetase and ligase
G4273_RS07755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4273_RS07800	COG1414	Transcriptional regulator
G4273_RS07805	COG4948	Mandelate Racemase Muconate Lactonizing
G4273_RS07810	COG2271	Major facilitator Superfamily
G4273_RS07825	COG5464	transposase or invertase
G4273_RS07830	COG0247	lactate metabolic process
G4273_RS07840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4273_RS07845	COG2271	Major facilitator Superfamily
G4273_RS07850	COG0584	glycerophosphoryl diester phosphodiesterase
G4273_RS07855	COG3642	lipopolysaccharide core region biosynthetic process
G4273_RS07860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4273_RS07865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4273_RS07870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4273_RS07875	COG3468	outer membrane autotransporter barrel domain protein
G4273_RS07885	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4273_RS07890	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
G4273_RS07895	COG3234	Protein of unknown function (DUF1175)
G4273_RS07900	COG2373	Large extracellular alpha-helical protein
G4273_RS07905	COG5445	Predicted secreted protein (DUF2300)
G4273_RS07910	COG4676	Protein conserved in bacteria
G4273_RS07915	COG0183	Belongs to the thiolase family
G4273_RS07920	COG2031	fatty acid transporter
G4273_RS07925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4273_RS07930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G4273_RS07935	COG2204	response regulator
G4273_RS07940	COG3852	Histidine kinase
G4273_RS07945	COG2205	protein histidine kinase activity
G4273_RS07945	COG0784	Response regulator, receiver
G4273_RS07950	COG2197	response regulator
G4273_RS07955	COG2198	Histidine kinase
G4273_RS07955	COG0642	Histidine kinase
G4273_RS07960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G4273_RS07965	COG1477	protein flavinylation
G4273_RS07970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4273_RS07970	COG2169	Transcriptional regulator
G4273_RS07975	COG3145	DNA-N1-methyladenine dioxygenase activity
G4273_RS07980	COG4615	Cyclic peptide transporter
G4273_RS07985	COG0579	oxidoreductase
G4273_RS08000	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS08000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4273_RS08005	COG3062	negative regulation of establishment of protein localization
G4273_RS08015	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS08020	COG0348	domain, Protein
G4273_RS08025	COG3043	anaerobic respiration
G4273_RS08030	COG3005	denitrification pathway
G4273_RS08035	COG4133	protoheme IX ABC transporter activity
G4273_RS08040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4273_RS08045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4273_RS08050	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4273_RS08060	COG1138	Cytochrome C-type biogenesis protein
G4273_RS08065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4273_RS08070	COG4235	cytochrome complex assembly
G4273_RS08070	COG3088	subunit of a heme lyase
G4273_RS08075	COG2197	response regulator
G4273_RS08090	COG3083	sulfuric ester hydrolase activity
G4273_RS08110	COG1061	Type III restriction enzyme res subunit
G4273_RS08115	COG1187	pseudouridine synthase activity
G4273_RS08120	COG2814	Major facilitator Superfamily
G4273_RS08130	COG4172	Belongs to the ABC transporter superfamily
G4273_RS08135	COG4239	(ABC) transporter, permease
G4273_RS08140	COG4174	ABC transporter (Permease)
G4273_RS08145	COG4166	transmembrane transport
G4273_RS08150	COG2200	EAL domain
G4273_RS08155	COG0791	NLP P60 protein
G4273_RS08160	COG0671	phosphoesterase, PA-phosphatase related
G4273_RS08165	COG0523	cobalamin synthesis protein
G4273_RS08170	COG0246	Mannitol dehydrogenase
G4273_RS08185	COG2814	Major facilitator Superfamily
G4273_RS08190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS08190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS08195	COG1105	Belongs to the carbohydrate kinase PfkB family
G4273_RS08200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS08200	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
G4273_RS08200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS08205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS08210	COG2313	pseudouridylate synthase activity
G4273_RS08215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4273_RS08220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4273_RS08230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS08230	COG1522	sequence-specific DNA binding
G4273_RS08240	COG2855	membrane
G4273_RS08245	COG0583	DNA-binding transcription factor activity
G4273_RS08250	COG0833	amino acid
G4273_RS08255	COG4771	TonB-dependent receptor
G4273_RS08270	COG2311	Membrane
G4273_RS08275	COG1609	Transcriptional regulator
G4273_RS08280	COG1879	ABC-type sugar transport system periplasmic component
G4273_RS08290	COG4211	Belongs to the binding-protein-dependent transport system permease family
G4273_RS08295	COG0167	dihydroorotate dehydrogenase activity
G4273_RS08295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G4273_RS08300	COG0493	'glutamate synthase
G4273_RS08310	COG2949	membrane
G4273_RS08320	COG1346	cytolysis
G4273_RS08330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4273_RS08340	COG1538	Outer membrane efflux protein
G4273_RS08345	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS08350	COG0586	Pfam SNARE associated Golgi protein
G4273_RS08360	COG1686	Belongs to the peptidase S11 family
G4273_RS08365	COG0277	FAD linked oxidase domain protein
G4273_RS08370	COG1472	Belongs to the glycosyl hydrolase 3 family
G4273_RS08375	COG1732	Glycine betaine
G4273_RS08380	COG1174	glycine betaine transport
G4273_RS08385	COG1125	glycine betaine transport
G4273_RS08390	COG1174	glycine betaine transport
G4273_RS08400	COG0789	Transcriptional regulator
G4273_RS08405	COG3275	phosphorelay sensor kinase activity
G4273_RS08410	COG3279	Response regulator of the LytR AlgR family
G4273_RS08415	COG4807	Protein conserved in bacteria
G4273_RS08420	COG4808	Protein conserved in bacteria
G4273_RS08425	COG4715	Zinc finger, swim domain protein
G4273_RS08430	COG3552	Protein containing von Willebrand factor type A (VWA) domain
G4273_RS08435	COG2425	protein containing a von Willebrand factor type A (vWA) domain
G4273_RS08440	COG0714	Associated with various cellular activities
G4273_RS08450	COG3831	ATPase activity
G4273_RS08455	COG3831	ATPase activity
G4273_RS08465	COG0489	protein tyrosine kinase activity
G4273_RS08475	COG3539	Fimbrial protein
G4273_RS08480	COG3121	Chaperone
G4273_RS08485	COG3188	usher protein
G4273_RS08490	COG3539	Fimbrial protein
G4273_RS08495	COG5455	response to cobalt ion
G4273_RS08515	COG0351	phosphomethylpyrimidine kinase
G4273_RS08520	COG3757	hydrolase, family 25
G4273_RS08525	COG2188	Transcriptional regulator
G4273_RS08530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS08535	COG1397	ADP-ribosylglycohydrolase
G4273_RS08540	COG2211	Major facilitator Superfamily
G4273_RS08545	COG1830	Aldolase
G4273_RS08560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS08565	COG3414	Phosphotransferase system galactitol-specific IIB component
G4273_RS08570	COG3775	system Galactitol-specific IIC component
G4273_RS08575	COG1063	alcohol dehydrogenase
G4273_RS08625	COG0745	RESPONSE REGULATOR receiver
G4273_RS08630	COG2205	protein histidine kinase activity
G4273_RS08665	COG4245	von Willebrand factor, type A
G4273_RS08670	COG0631	protein serine/threonine phosphatase activity
G4273_RS08675	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
G4273_RS08680	COG0443	Heat shock 70 kDa protein
G4273_RS08685	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G4273_RS08695	COG0572	uridine kinase
G4273_RS08705	COG2982	Protein involved in outer membrane biogenesis
G4273_RS08710	COG1253	flavin adenine dinucleotide binding
G4273_RS08720	COG1596	polysaccharide export
G4273_RS08725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4273_RS08730	COG0489	protein tyrosine kinase activity
G4273_RS08730	COG3206	protein involved in exopolysaccharide biosynthesis
G4273_RS08735	COG0463	Glycosyl transferase, family 2
G4273_RS08740	COG1045	serine acetyltransferase
G4273_RS08745	COG0438	transferase activity, transferring glycosyl groups
G4273_RS08755	COG1216	Glycosyl transferase, family 2
G4273_RS08760	COG0110	maltose O-acetyltransferase activity
G4273_RS08765	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G4273_RS08770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4273_RS08775	COG1051	belongs to the nudix hydrolase family
G4273_RS08780	COG0297	glycogen (starch) synthase activity
G4273_RS08785	COG0662	Cupin 2, conserved barrel domain protein
G4273_RS08785	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G4273_RS08790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4273_RS08795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4273_RS08800	COG2244	polysaccharide biosynthetic process
G4273_RS08805	COG2327	Polysaccharide pyruvyl transferase
G4273_RS08810	COG0438	transferase activity, transferring glycosyl groups
G4273_RS08820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4273_RS08825	COG1088	dTDP-glucose 4,6-dehydratase activity
G4273_RS08835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G4273_RS08850	COG1216	Glycosyl transferase, family 2
G4273_RS08860	COG0438	transferase activity, transferring glycosyl groups
G4273_RS08875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G4273_RS08890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4273_RS08895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4273_RS08925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4273_RS08940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4273_RS08955	COG2161	toxin-antitoxin pair type II binding
G4273_RS08960	COG4115	mRNA cleavage
G4273_RS08965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4273_RS08970	COG0583	DNA-binding transcription factor activity
G4273_RS08980	COG0531	amino acid
G4273_RS08985	COG2391	methyltransferase activity
G4273_RS08990	COG0425	Belongs to the sulfur carrier protein TusA family
G4273_RS08995	COG2925	Exonuclease
G4273_RS09000	COG0582	viral genome integration into host DNA
G4273_RS09025	COG2246	polysaccharide biosynthetic process
G4273_RS09030	COG1686	Belongs to the peptidase S11 family
G4273_RS09040	COG1289	transmembrane transporter activity
G4273_RS09085	COG2003	Belongs to the UPF0758 family
G4273_RS09140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4273_RS09145	COG1120	ATPase activity
G4273_RS09195	COG3547	Transposase (IS116 IS110 IS902 family)
G4273_RS09230	COG1735	metal-dependent hydrolase with the TIM-barrel fold
G4273_RS09245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS09265	COG1215	transferase activity, transferring glycosyl groups
G4273_RS09270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4273_RS09275	COG3969	phosphoadenosine phosphosulfate
G4273_RS09280	COG1475	DNA binding
G4273_RS09285	COG4771	TonB-dependent receptor
G4273_RS09290	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
G4273_RS09305	COG1376	ErfK ybiS ycfS ynhG family protein
G4273_RS09325	COG2197	response regulator
G4273_RS09340	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4273_RS09345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4273_RS09350	COG1960	acyl-CoA dehydrogenase activity
G4273_RS09380	COG0154	amidase activity
G4273_RS09405	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
G4273_RS09425	COG0534	Mate efflux family protein
G4273_RS09435	COG0583	DNA-binding transcription factor activity
G4273_RS09440	COG0583	DNA-binding transcription factor activity
G4273_RS09450	COG0217	transcriptional regulatory protein
G4273_RS09455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4273_RS09460	COG0477	Major facilitator Superfamily
G4273_RS09470	COG1470	cell adhesion involved in biofilm formation
G4273_RS09470	COG1388	LysM domain
G4273_RS09480	COG1388	LysM domain
G4273_RS09480	COG2373	Large extracellular alpha-helical protein
G4273_RS09480	COG4932	domain protein
G4273_RS09485	COG4771	TonB-dependent receptor
G4273_RS09490	COG1021	2,3-dihydroxybenzoate-AMP ligase
G4273_RS09510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4273_RS09510	COG2226	methyltransferase
G4273_RS09510	COG3433	isochorismatase activity
G4273_RS09525	COG1132	(ABC) transporter
G4273_RS09530	COG2814	Major facilitator Superfamily
G4273_RS09540	COG0582	viral genome integration into host DNA
G4273_RS09680	COG0582	viral genome integration into host DNA
G4273_RS09685	COG3443	Belongs to the bacterial solute-binding protein 9 family
G4273_RS09690	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G4273_RS09695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4273_RS09700	COG2351	hydroxyisourate hydrolase activity
G4273_RS09705	COG0745	RESPONSE REGULATOR receiver
G4273_RS09710	COG2205	protein histidine kinase activity
G4273_RS09720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G4273_RS09730	COG1418	mRNA catabolic process
G4273_RS09735	COG0270	DNA (cytosine-5-)-methyltransferase activity
G4273_RS09740	COG3727	T/G mismatch-specific endonuclease activity
G4273_RS09745	COG0697	spore germination
G4273_RS09750	COG2354	Protein conserved in bacteria
G4273_RS09755	COG5475	Uncharacterized small protein (DUF2158)
G4273_RS09760	COG3706	GGDEF domain
G4273_RS09765	COG3769	mannosylglycerate metabolic process
G4273_RS09780	COG2197	response regulator
G4273_RS09785	COG1684	flagellar biosynthetic protein fliR
G4273_RS09790	COG1987	bacterial-type flagellum assembly
G4273_RS09795	COG1338	Plays a role in the flagellum-specific transport system
G4273_RS09800	COG3190	flagellar
G4273_RS09805	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4273_RS09810	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4273_RS09815	COG1580	Controls the rotational direction of flagella during chemotaxis
G4273_RS09820	COG3144	bacterial-type flagellum assembly
G4273_RS09825	COG2882	bacterial-type flagellum organization
G4273_RS09830	COG1157	protein secretion by the type III secretion system
G4273_RS09835	COG1317	bacterial-type flagellum organization
G4273_RS09840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4273_RS09845	COG1766	The M ring may be actively involved in energy transduction
G4273_RS09855	COG2076	Multidrug Resistance protein
G4273_RS09860	COG1881	PFAM PEBP family protein
G4273_RS09865	COG2207	Transcriptional regulator
G4273_RS09880	COG2135	peptidase activity
G4273_RS09885	COG0425	Belongs to the sulfur carrier protein TusA family
G4273_RS09890	COG2391	methyltransferase activity
G4273_RS09900	COG0366	Alpha amylase catalytic
G4273_RS09910	COG1516	flagellar protein fliS
G4273_RS09915	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G4273_RS09925	COG1191	sigma factor activity
G4273_RS09955	COG2197	response regulator
G4273_RS09970	COG2197	response regulator
G4273_RS10000	COG3012	SEC-C Motif Domain Protein
G4273_RS10000	COG3318	Belongs to the UPF0149 family
G4273_RS10005	COG0814	amino acid
G4273_RS10015	COG1528	Iron-storage protein
G4273_RS10035	COG1528	Iron-storage protein
G4273_RS10040	COG1879	ABC-type sugar transport system periplasmic component
G4273_RS10050	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4273_RS10055	COG1877	trehalose-phosphatase activity
G4273_RS10075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4273_RS10080	COG1360	Flagellar Motor Protein
G4273_RS10085	COG0643	Histidine kinase
G4273_RS10085	COG2198	Histidine kinase
G4273_RS10090	COG0835	chemotaxis
G4273_RS10095	COG0840	transmembrane signaling receptor activity
G4273_RS10105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G4273_RS10115	COG0745	RESPONSE REGULATOR receiver
G4273_RS10120	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G4273_RS10125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4273_RS10130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4273_RS10145	COG3102	Protein conserved in bacteria
G4273_RS10155	COG3005	denitrification pathway
G4273_RS10160	COG0243	molybdopterin cofactor binding
G4273_RS10175	COG3788	relative of glutathione S-transferase, MAPEG superfamily
G4273_RS10180	COG1801	Protein of unknown function DUF72
G4273_RS10185	COG1335	isochorismatase
G4273_RS10195	COG0494	nUDIX hydrolase
G4273_RS10200	COG0217	transcriptional regulatory protein
G4273_RS10230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4273_RS10240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
G4273_RS10245	COG0739	heme binding
G4273_RS10250	COG1560	Kdo2-lipid A biosynthetic process
G4273_RS10255	COG0469	pyruvate kinase activity
G4273_RS10260	COG1737	Transcriptional regulator
G4273_RS10265	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4273_RS10270	COG0129	dihydroxy-acid dehydratase activity
G4273_RS10275	COG0800	Aldolase
G4273_RS10285	COG3141	response to X-ray
G4273_RS10295	COG2979	Protein of unknown function (DUF533)
G4273_RS10300	COG1770	oligopeptidase
G4273_RS10305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4273_RS10310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4273_RS10320	COG2372	response to copper ion
G4273_RS10325	COG1276	copper resistance
G4273_RS10335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4273_RS10355	COG3008	intermembrane lipid transfer
G4273_RS10360	COG2995	paraquat-inducible protein a
G4273_RS10365	COG1956	GAF domain-containing protein
G4273_RS10375	COG0793	Belongs to the peptidase S41A family
G4273_RS10385	COG2814	Major facilitator Superfamily
G4273_RS10390	COG1414	Transcriptional regulator
G4273_RS10420	COG2226	methyltransferase
G4273_RS10435	COG3716	PTS system mannose fructose sorbose family IID component
G4273_RS10440	COG3715	PTS system
G4273_RS10445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS10445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS10450	COG1253	flavin adenine dinucleotide binding
G4273_RS10455	COG2200	EAL domain
G4273_RS10460	COG1760	l-serine dehydratase
G4273_RS10470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4273_RS10485	COG0251	oxidation-reduction process
G4273_RS10490	COG1199	ATP-dependent helicase activity
G4273_RS10495	COG1214	PFAM Peptidase M22, glycoprotease
G4273_RS10500	COG3065	identical protein binding
G4273_RS10505	COG0318	PFAM AMP-dependent synthetase and ligase
G4273_RS10510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G4273_RS10515	COG0583	DNA-binding transcription factor activity
G4273_RS10525	COG3615	Tellurite resistance protein tehB
G4273_RS10535	COG2261	transglycosylase associated protein
G4273_RS10550	COG2199	diguanylate cyclase activity
G4273_RS10550	COG2203	Gaf domain
G4273_RS10555	COG3042	response to heat
G4273_RS10560	COG3189	MarR family transcriptional regulator
G4273_RS10565	COG2807	transmembrane transport
G4273_RS10570	COG2207	Transcriptional regulator
G4273_RS10585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4273_RS10590	COG2199	diguanylate cyclase activity
G4273_RS10595	COG2199	diguanylate cyclase activity
G4273_RS10605	COG2766	serine protein kinase
G4273_RS10610	COG3713	MltA-interacting MipA family protein
G4273_RS10615	COG0656	L-ascorbic acid biosynthetic process
G4273_RS10620	COG0676	glucose-6-phosphate 1-epimerase activity
G4273_RS10625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4273_RS10635	COG3139	Protein of unknown function (DUF1315)
G4273_RS10640	COG1063	alcohol dehydrogenase
G4273_RS10645	COG2271	Major facilitator Superfamily
G4273_RS10650	COG1063	alcohol dehydrogenase
G4273_RS10655	COG0191	fructose-bisphosphate aldolase activity
G4273_RS10660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS10665	COG0667	Aldo Keto reductase
G4273_RS10670	COG1349	DNA-binding transcription factor activity
G4273_RS10675	COG2814	Major facilitator Superfamily
G4273_RS10680	COG1335	isochorismatase
G4273_RS10685	COG0252	asparaginase activity
G4273_RS10690	COG0616	signal peptide processing
G4273_RS10695	COG0778	Nitroreductase
G4273_RS10705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4273_RS10710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4273_RS10725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4273_RS10730	COG2897	thiosulfate sulfurtransferase activity
G4273_RS10735	COG4136	ATPase activity
G4273_RS10740	COG4135	transport system, permease component
G4273_RS10745	COG4134	Bacterial extracellular solute-binding protein
G4273_RS10750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4273_RS10755	COG0398	Pfam SNARE associated Golgi protein
G4273_RS10765	COG0398	Pfam SNARE associated Golgi protein
G4273_RS10770	COG0708	Exodeoxyribonuclease III
G4273_RS10800	COG3678	ATP-independent chaperone mediated protein folding
G4273_RS10810	COG0322	excinuclease ABC activity
G4273_RS10820	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4273_RS10825	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4273_RS10830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4273_RS10835	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4273_RS10840	COG2169	Transcriptional regulator
G4273_RS10840	COG1917	Cupin 2, conserved barrel domain protein
G4273_RS10845	COG1486	melibiose metabolic process
G4273_RS10855	COG0753	catalase activity
G4273_RS10870	COG1988	membrane-bound metal-dependent
G4273_RS10875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4273_RS10885	COG3001	Fructosamine kinase
G4273_RS10895	COG1105	Belongs to the carbohydrate kinase PfkB family
G4273_RS10900	COG3137	Salt-induced outer membrane protein
G4273_RS10960	COG0386	Belongs to the glutathione peroxidase family
G4273_RS10970	COG0791	NLP P60 protein
G4273_RS10975	COG2200	EAL domain
G4273_RS10985	COG4256	Hemin uptake protein
G4273_RS10990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4273_RS11000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4273_RS11000	COG0574	Belongs to the PEP-utilizing enzyme family
G4273_RS11005	COG0318	PFAM AMP-dependent synthetase and ligase
G4273_RS11010	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G4273_RS11015	COG0644	oxidoreductase
G4273_RS11020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4273_RS11025	COG2086	electron transfer activity
G4273_RS11030	COG2207	Transcriptional regulator
G4273_RS11030	COG1917	Cupin 2, conserved barrel domain protein
G4273_RS11035	COG1960	acyl-CoA dehydrogenase activity
G4273_RS11040	COG4670	ketone body catabolic process
G4273_RS11055	COG2271	Major facilitator Superfamily
G4273_RS11060	COG0738	Major facilitator superfamily
G4273_RS11075	COG0628	permease
G4273_RS11080	COG0247	lactate metabolic process
G4273_RS11080	COG0277	FAD linked oxidase domain protein
G4273_RS11085	COG2050	protein possibly involved in aromatic compounds catabolism
G4273_RS11095	COG0316	Belongs to the HesB IscA family
G4273_RS11100	COG0719	Fe-S assembly protein
G4273_RS11105	COG0396	ATPase activity
G4273_RS11110	COG0719	Fe-S assembly protein
G4273_RS11125	COG1376	ErfK ybiS ycfS ynhG family protein
G4273_RS11130	COG4238	major outer membrane lipoprotein
G4273_RS11135	COG0469	pyruvate kinase activity
G4273_RS11145	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS11150	COG2414	aldehyde ferredoxin oxidoreductase
G4273_RS11160	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS11165	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
G4273_RS11175	COG4529	Protein conserved in bacteria
G4273_RS11200	COG3468	outer membrane autotransporter barrel domain protein
G4273_RS11210	COG0307	riboflavin synthase, alpha
G4273_RS11215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4273_RS11220	COG2814	Major facilitator Superfamily
G4273_RS11225	COG0583	DNA-binding transcription factor activity
G4273_RS11240	COG2814	Major facilitator Superfamily
G4273_RS11245	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4273_RS11250	COG0791	NLP P60 protein
G4273_RS11255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G4273_RS11265	COG0346	lactoylglutathione lyase activity
G4273_RS11270	COG1902	pentaerythritol trinitrate reductase activity
G4273_RS11275	COG1309	transcriptional regulator
G4273_RS11280	COG3313	Fe-S protein
G4273_RS11285	COG4989	oxidoreductase activity
G4273_RS11290	COG2032	superoxide dismutase activity
G4273_RS11295	COG1289	transmembrane transporter activity
G4273_RS11300	COG1566	PFAM secretion protein HlyD family protein
G4273_RS11315	COG3133	Outer membrane lipoprotein
G4273_RS11325	COG3895	Periplasmic Protein
G4273_RS11345	COG0625	glutathione transferase activity
G4273_RS11350	COG3104	oligopeptide transport
G4273_RS11355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4273_RS11360	COG4660	Part of a membrane complex involved in electron transport
G4273_RS11365	COG4659	FMN binding
G4273_RS11405	COG0673	inositol 2-dehydrogenase activity
G4273_RS11415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4273_RS11420	COG1263	PTS System
G4273_RS11420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS11425	COG1609	Transcriptional regulator
G4273_RS11430	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS11435	COG1309	transcriptional regulator
G4273_RS11440	COG3250	beta-galactosidase activity
G4273_RS11455	COG5339	Protein conserved in bacteria
G4273_RS11460	COG1482	cell wall glycoprotein biosynthetic process
G4273_RS11465	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G4273_RS11465	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4273_RS11470	COG0114	fumarate hydratase activity
G4273_RS11480	COG2205	protein histidine kinase activity
G4273_RS11485	COG0745	RESPONSE REGULATOR receiver
G4273_RS11490	COG3136	membrane protein required for alginate biosynthesis
G4273_RS11500	COG0531	amino acid
G4273_RS11510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G4273_RS11515	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
G4273_RS11520	COG0628	permease
G4273_RS11535	COG3591	Belongs to the peptidase S1B family
G4273_RS11550	COG2814	Major facilitator Superfamily
G4273_RS11555	COG0583	DNA-binding transcription factor activity
G4273_RS11560	COG1940	carbohydrate kinase activity
G4273_RS11565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G4273_RS11575	COG3381	protein complex oligomerization
G4273_RS11580	COG3302	dmso reductase anchor subunit
G4273_RS11585	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS11590	COG0243	molybdopterin cofactor binding
G4273_RS11595	COG0243	molybdopterin cofactor binding
G4273_RS11610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4273_RS11625	COG4948	Mandelate Racemase Muconate Lactonizing
G4273_RS11630	COG1063	alcohol dehydrogenase
G4273_RS11635	COG0477	Major facilitator Superfamily
G4273_RS11640	COG0246	Mannitol dehydrogenase
G4273_RS11650	COG1802	Transcriptional regulator
G4273_RS11655	COG4221	oxidoreductase activity
G4273_RS11660	COG0339	signal peptide processing
G4273_RS11665	COG3111	PFAM Bacterial OB fold (BOF) protein
G4273_RS11670	COG3706	GGDEF domain
G4273_RS11680	COG2814	Major facilitator Superfamily
G4273_RS11685	COG0697	spore germination
G4273_RS11690	COG2188	Transcriptional regulator
G4273_RS11700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
G4273_RS11705	COG1447	Phosphotransferase system cellobiose-specific component IIA
G4273_RS11715	COG2723	6-phospho-beta-galactosidase activity
G4273_RS11725	COG4977	sequence-specific DNA binding
G4273_RS11730	COG1846	Transcriptional regulator
G4273_RS11750	COG0583	DNA-binding transcription factor activity
G4273_RS11755	COG1012	belongs to the aldehyde dehydrogenase family
G4273_RS11760	COG2066	Belongs to the glutaminase family
G4273_RS11775	COG2199	diguanylate cyclase activity
G4273_RS11785	COG3781	membrane
G4273_RS11795	COG1396	sequence-specific DNA binding
G4273_RS11800	COG3550	peptidyl-serine autophosphorylation
G4273_RS11830	COG0702	epimerase
G4273_RS11835	COG3539	Fimbrial protein
G4273_RS11845	COG3188	usher protein
G4273_RS11850	COG3539	Fimbrial protein
G4273_RS11855	COG3539	Fimbrial protein
G4273_RS11860	COG3539	Fimbrial protein
G4273_RS11865	COG0243	molybdopterin cofactor binding
G4273_RS11875	COG2207	Transcriptional regulator
G4273_RS11880	COG3119	arylsulfatase activity
G4273_RS11885	COG0641	radical SAM
G4273_RS11900	COG0076	glutamate decarboxylase activity
G4273_RS11905	COG0531	amino acid
G4273_RS11925	COG1764	response to oxidative stress
G4273_RS11945	COG1064	alcohol dehydrogenase
G4273_RS11955	COG3093	addiction module antidote protein HigA
G4273_RS11960	COG2864	formate dehydrogenase
G4273_RS11965	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS11975	COG0697	spore germination
G4273_RS11980	COG2223	nitrite transmembrane transporter activity
G4273_RS11985	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G4273_RS11990	COG1140	nitrate reductase beta subunit
G4273_RS11995	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G4273_RS12000	COG2181	nitrate reductase activity
G4273_RS12005	COG0384	phenazine biosynthesis protein PhzF
G4273_RS12010	COG2162	N-hydroxyarylamine O-acetyltransferase activity
G4273_RS12020	COG3501	Rhs element vgr protein
G4273_RS12030	COG0625	glutathione transferase activity
G4273_RS12035	COG0625	glutathione transferase activity
G4273_RS12040	COG1113	amino acid transport
G4273_RS12060	COG1247	-acetyltransferase
G4273_RS12065	COG3238	Protein conserved in bacteria
G4273_RS12090	COG1177	transmembrane transport
G4273_RS12095	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4273_RS12100	COG3842	ATPase activity
G4273_RS12105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4273_RS12110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4273_RS12125	COG0826	peptidase U32
G4273_RS12130	COG1396	sequence-specific DNA binding
G4273_RS12135	COG3135	benzoate transporter
G4273_RS12145	COG0500	methyltransferase
G4273_RS12150	COG1275	C4-dicarboxylate transporter malic acid transport protein
G4273_RS12155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4273_RS12160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4273_RS12165	COG2841	Protein conserved in bacteria
G4273_RS12175	COG5383	Protein conserved in bacteria
G4273_RS12180	COG0583	DNA-binding transcription factor activity
G4273_RS12200	COG3038	cytochrome b561
G4273_RS12205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4273_RS12210	COG1012	belongs to the aldehyde dehydrogenase family
G4273_RS12215	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G4273_RS12220	COG1643	Atp-dependent helicase
G4273_RS12230	COG0671	phosphoesterase, PA-phosphatase related
G4273_RS12230	COG2453	phosphatase
G4273_RS12235	COG2267	carboxylic ester hydrolase activity
G4273_RS12240	COG4589	Belongs to the CDS family
G4273_RS12250	COG0667	Aldo Keto reductase
G4273_RS12260	COG3784	Protein of unknown function (DUF1318)
G4273_RS12270	COG2911	Protein conserved in bacteria
G4273_RS12275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4273_RS12280	COG3187	Heat shock protein
G4273_RS12285	COG3042	response to heat
G4273_RS12290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G4273_RS12290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4273_RS12290	COG0674	pyruvate-flavodoxin oxidoreductase activity
G4273_RS12290	COG1013	pyruvate-flavodoxin oxidoreductase activity
G4273_RS12295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G4273_RS12300	COG0589	response to stress
G4273_RS12325	COG0513	Belongs to the DEAD box helicase family
G4273_RS12335	COG3706	GGDEF domain
G4273_RS12340	COG2840	Smr protein MutS2
G4273_RS12355	COG2207	Transcriptional regulator
G4273_RS12365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4273_RS12370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4273_RS12375	COG0589	response to stress
G4273_RS12380	COG3182	Iron-regulated membrane protein
G4273_RS12385	COG0668	transmembrane transport
G4273_RS12390	COG4166	transmembrane transport
G4273_RS12395	COG0583	DNA-binding transcription factor activity
G4273_RS12400	COG1073	alpha beta
G4273_RS12410	COG0702	epimerase
G4273_RS12415	COG2866	Carboxypeptidase
G4273_RS12420	COG4948	Mandelate Racemase Muconate Lactonizing
G4273_RS12425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G4273_RS12430	COG3283	Transcriptional regulator of aromatic amino acids metabolism
G4273_RS12440	COG3106	COG3106 Predicted ATPase
G4273_RS12445	COG1609	Transcriptional regulator
G4273_RS12460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4273_RS12465	COG1554	hydrolase, family 65, central catalytic
G4273_RS12470	COG0673	inositol 2-dehydrogenase activity
G4273_RS12475	COG1082	Xylose isomerase domain protein TIM barrel
G4273_RS12480	COG1063	alcohol dehydrogenase
G4273_RS12485	COG0395	ABC-type sugar transport system, permease component
G4273_RS12490	COG1175	transmembrane transport
G4273_RS12495	COG1653	transport
G4273_RS12500	COG0366	Alpha amylase catalytic
G4273_RS12505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4273_RS12515	COG1983	PspC domain protein
G4273_RS12525	COG1842	Phage shock protein A
G4273_RS12530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
G4273_RS12545	COG4166	transmembrane transport
G4273_RS12550	COG4168	peptide transport system, permease
G4273_RS12555	COG4171	peptide transport system, permease
G4273_RS12560	COG4172	Belongs to the ABC transporter superfamily
G4273_RS12565	COG4172	Belongs to the ABC transporter superfamily
G4273_RS12570	COG2814	Major facilitator Superfamily
G4273_RS12580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4273_RS12585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4273_RS12595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G4273_RS12600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4273_RS12600	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4273_RS12615	COG5001	Diguanylate cyclase
G4273_RS12625	COG1349	DNA-binding transcription factor activity
G4273_RS12635	COG0023	Translation Initiation Factor
G4273_RS12645	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G4273_RS12650	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
G4273_RS12655	COG0671	phosphoesterase, PA-phosphatase related
G4273_RS12665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4273_RS12685	COG0583	DNA-binding transcription factor activity
G4273_RS12690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4273_RS12700	COG0616	signal peptide processing
G4273_RS12705	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS12710	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
G4273_RS12715	COG1187	pseudouridine synthase activity
G4273_RS12720	COG4907	membrane protein (DUF2207)
G4273_RS12725	COG0009	L-threonylcarbamoyladenylate synthase
G4273_RS12730	COG0613	PHP domain protein
G4273_RS12740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4273_RS12745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4273_RS12745	COG0512	Glutamine amidotransferase of anthranilate synthase
G4273_RS12750	COG0135	phosphoribosylanthranilate isomerase activity
G4273_RS12750	COG0134	indole-3-glycerol-phosphate synthase activity
G4273_RS12765	COG3685	Protein conserved in bacteria
G4273_RS12770	COG3685	Protein conserved in bacteria
G4273_RS12775	COG3047	cAMP biosynthetic process
G4273_RS12795	COG1607	acyl-coa hydrolase
G4273_RS12805	COG2350	Protein conserved in bacteria
G4273_RS12810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4273_RS12830	COG4608	Belongs to the ABC transporter superfamily
G4273_RS12835	COG0444	Belongs to the ABC transporter superfamily
G4273_RS12840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4273_RS12845	COG0601	transmembrane transport
G4273_RS12850	COG4166	transmembrane transport
G4273_RS12855	COG2095	MarC family integral membrane protein
G4273_RS12860	COG1454	alcohol dehydrogenase
G4273_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
G4273_RS12870	COG1435	thymidine kinase activity
G4273_RS12880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4273_RS12885	COG0745	RESPONSE REGULATOR receiver
G4273_RS12890	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4273_RS12900	COG0788	formyltetrahydrofolate deformylase activity
G4273_RS12925	COG2181	nitrate reductase activity
G4273_RS12930	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G4273_RS12935	COG1140	nitrate reductase beta subunit
G4273_RS12940	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G4273_RS12945	COG2223	nitrite transmembrane transporter activity
G4273_RS12950	COG3850	Histidine kinase
G4273_RS12955	COG2197	response regulator
G4273_RS12960	COG4932	domain protein
G4273_RS12965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
G4273_RS12970	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G4273_RS12975	COG4572	Cation transport regulator
G4273_RS12980	COG0387	Pfam Sodium calcium exchanger
G4273_RS12995	COG2912	Transglutaminase-like superfamily
G4273_RS13000	COG3094	Invasion gene expression up-regulator, SirB
G4273_RS13005	COG2890	protein-(glutamine-N5) methyltransferase activity
G4273_RS13030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4273_RS13035	COG0659	secondary active sulfate transmembrane transporter activity
G4273_RS13050	COG0012	GTP binding
G4273_RS13060	COG3284	Transcriptional regulator
G4273_RS13065	COG2376	Dihydroxyacetone kinase
G4273_RS13070	COG1461	Dihydroxyacetone kinase
G4273_RS13075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4273_RS13075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS13075	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
G4273_RS13095	COG1120	ATPase activity
G4273_RS13100	COG0500	methyltransferase
G4273_RS13105	COG0157	Belongs to the NadC ModD family
G4273_RS13120	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G4273_RS13130	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4273_RS13140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4273_RS13150	COG2719	SpoVR family
G4273_RS13170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4273_RS13175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4273_RS13190	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4273_RS13215	COG2894	cell division
G4273_RS13295	COG2200	EAL domain
G4273_RS13300	COG0789	Transcriptional regulator
G4273_RS13305	COG5562	phage envelope protein
G4273_RS13315	COG0538	isocitrate dehydrogenase activity
G4273_RS13330	COG1121	(ABC) transporter
G4273_RS13335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4273_RS13340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4273_RS13355	COG5301	cellulose 1,4-beta-cellobiosidase activity
G4273_RS13385	COG1196	nuclear chromosome segregation
G4273_RS13455	COG4220	transposase activity
G4273_RS13480	COG3772	lysozyme
G4273_RS13685	COG0582	viral genome integration into host DNA
G4273_RS13690	COG0538	isocitrate dehydrogenase activity
G4273_RS13695	COG1187	pseudouridine synthase activity
G4273_RS13715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4273_RS13725	COG2205	protein histidine kinase activity
G4273_RS13730	COG2850	peptidyl-arginine hydroxylation
G4273_RS13740	COG3842	ATPase activity
G4273_RS13750	COG1177	transmembrane transport
G4273_RS13755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4273_RS13765	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G4273_RS13770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4273_RS13780	COG4591	ABC-type transport system involved in lipoprotein release permease component
G4273_RS13790	COG4591	ABC-type transport system involved in lipoprotein release permease component
G4273_RS13795	COG4763	Acyl-transferase
G4273_RS13800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4273_RS13805	COG1376	ErfK ybiS ycfS ynhG family protein
G4273_RS13805	COG1388	LysM domain
G4273_RS13815	COG1309	transcriptional regulator
G4273_RS13820	COG3134	Outer membrane lipoprotein
G4273_RS13825	COG1252	NADH dehydrogenase
G4273_RS13845	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
G4273_RS13850	COG5633	Lipoprotein
G4273_RS13855	COG0537	adenosine 5'-monophosphoramidase activity
G4273_RS13860	COG4773	Receptor
G4273_RS13865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS13865	COG1263	PTS System
G4273_RS13870	COG0084	hydrolase, TatD family'
G4273_RS13875	COG0470	DNA polymerase III
G4273_RS13885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4273_RS13890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4273_RS13895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4273_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS13910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4273_RS13930	COG1399	metal-binding, possibly nucleic acid-binding protein
G4273_RS13935	COG0424	maF-like protein
G4273_RS13940	COG0564	pseudouridine synthase activity
G4273_RS13945	COG1530	ribonuclease E activity
G4273_RS13950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4273_RS13955	COG1256	bacterial-type flagellum assembly
G4273_RS13960	COG1705	Flagellar rod assembly protein muramidase FlgJ
G4273_RS13960	COG3951	Flagellar rod assembly protein muramidase FlgJ
G4273_RS13975	COG4786	Flagellar basal body rod
G4273_RS13980	COG4787	bacterial-type flagellum-dependent cell motility
G4273_RS13985	COG1749	Flagellar hook protein flgE
G4273_RS13990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G4273_RS13995	COG1558	bacterial-type flagellum-dependent cell motility
G4273_RS14000	COG1815	bacterial-type flagellum-dependent cell motility
G4273_RS14005	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
G4273_RS14010	COG2747	anti-sigma28 factor FlgM
G4273_RS14015	COG3418	PFAM FlgN family protein
G4273_RS14020	COG0728	peptidoglycan biosynthetic process
G4273_RS14025	COG0673	inositol 2-dehydrogenase activity
G4273_RS14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4273_RS14045	COG2999	glutathione oxidoreductase activity
G4273_RS14070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4273_RS14080	COG3038	cytochrome b561
G4273_RS14085	COG2353	YceI-like domain
G4273_RS14095	COG1560	Kdo2-lipid A biosynthetic process
G4273_RS14110	COG5645	(Lipo)protein
G4273_RS14115	COG2943	transferase activity, transferring hexosyl groups
G4273_RS14130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4273_RS14135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G4273_RS14160	COG2197	response regulator
G4273_RS14175	COG1462	curli production assembly transport component CsgG
G4273_RS14185	COG3381	protein complex oligomerization
G4273_RS14205	COG3706	GGDEF domain
G4273_RS14210	COG0457	Tetratricopeptide repeat
G4273_RS14215	COG0726	polysaccharide deacetylase
G4273_RS14215	COG1649	PFAM Uncharacterised BCR, COG1649
G4273_RS14220	COG1215	transferase activity, transferring glycosyl groups
G4273_RS14225	COG3658	cytochrome
G4273_RS14230	COG1702	phosphate starvation-inducible protein PhoH
G4273_RS14250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4273_RS14260	COG0506	proline dehydrogenase activity
G4273_RS14260	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G4273_RS14260	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G4273_RS14265	COG1309	transcriptional regulator
G4273_RS14295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4273_RS14300	COG2233	PERMEase
G4273_RS14305	COG3729	General stress protein
G4273_RS14335	COG3381	protein complex oligomerization
G4273_RS14340	COG0243	molybdopterin cofactor binding
G4273_RS14345	COG3005	denitrification pathway
G4273_RS14350	COG0745	RESPONSE REGULATOR receiver
G4273_RS14355	COG1879	ABC-type sugar transport system periplasmic component
G4273_RS14360	COG0784	Response regulator, receiver
G4273_RS14360	COG2198	Histidine kinase
G4273_RS14360	COG2205	protein histidine kinase activity
G4273_RS14365	COG0348	domain, Protein
G4273_RS14385	COG1278	Cold shock
G4273_RS14390	COG1278	Cold shock
G4273_RS14405	COG1294	oxidase, subunit
G4273_RS14410	COG1271	oxidase subunit
G4273_RS14415	COG1773	rubredoxin
G4273_RS14420	COG1999	signal sequence binding
G4273_RS14425	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G4273_RS14430	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
G4273_RS14435	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G4273_RS14440	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G4273_RS14450	COG0670	Belongs to the BI1 family
G4273_RS14455	COG2920	part of a sulfur-relay system
G4273_RS14475	COG1832	CoA-binding protein
G4273_RS14490	COG0210	DNA helicase
G4273_RS14495	COG3304	Inner membrane component domain
G4273_RS14500	COG1289	transmembrane transporter activity
G4273_RS14505	COG3070	regulator of competence-specific genes
G4273_RS14515	COG2885	chlorophyll binding
G4273_RS14515	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G4273_RS14525	COG1067	ATP-dependent peptidase activity
G4273_RS14535	COG3130	regulation of translation
G4273_RS14540	COG3009	Protein conserved in bacteria
G4273_RS14545	COG3008	intermembrane lipid transfer
G4273_RS14545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4273_RS14550	COG2995	paraquat-inducible protein a
G4273_RS14555	COG0488	(ABC) transporter
G4273_RS14560	COG0116	Belongs to the methyltransferase superfamily
G4273_RS14560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4273_RS14565	COG3217	Mosc domain protein beta barrel domain protein
G4273_RS14565	COG0633	Ferredoxin
G4273_RS14580	COG0431	NADPH-dependent FMN reductase
G4273_RS14585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4273_RS14595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4273_RS14605	COG0308	aminopeptidase N
G4273_RS14625	COG1448	Aminotransferase
G4273_RS14630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4273_RS14635	COG3108	Peptidase M15
G4273_RS14645	COG2989	Protein conserved in bacteria
G4273_RS14655	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
G4273_RS14665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4273_RS14670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G4273_RS14675	COG3173	Aminoglycoside phosphotransferase
G4273_RS14690	COG3214	Protein conserved in bacteria
G4273_RS14705	COG2333	competence protein COMEC
G4273_RS14705	COG0658	competence protein
G4273_RS14715	COG0539	negative regulation of cytoplasmic translation
G4273_RS14725	COG0501	Belongs to the peptidase M48B family
G4273_RS14740	COG2323	membrane
G4273_RS14745	COG1944	ATP diphosphatase activity
G4273_RS14750	COG2116	formate transmembrane transporter activity
G4273_RS14755	COG1882	Formate acetyltransferase
G4273_RS14760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4273_RS14770	COG1335	isochorismatase
G4273_RS14775	COG3302	dmso reductase anchor subunit
G4273_RS14780	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS14785	COG0243	molybdopterin cofactor binding
G4273_RS14795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4273_RS14805	COG1674	ftsk spoiiie
G4273_RS14805	COG1178	ABC-type Fe3 transport system permease component
G4273_RS14810	COG1522	sequence-specific DNA binding
G4273_RS14815	COG0492	ferredoxin-NADP+ reductase activity
G4273_RS14820	COG4988	ABC transporter
G4273_RS14825	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4273_RS14845	COG0542	response to heat
G4273_RS14855	COG1278	Cold shock
G4273_RS14865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4273_RS14870	COG2990	Protein conserved in bacteria
G4273_RS14875	COG3593	DNA synthesis involved in DNA repair
G4273_RS14885	COG2431	L-lysine efflux transmembrane transporter activity
G4273_RS14890	COG1151	hydroxylamine reductase activity
G4273_RS14895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4273_RS14900	COG0028	Belongs to the TPP enzyme family
G4273_RS14905	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
G4273_RS14910	COG0702	epimerase
G4273_RS14915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4273_RS14920	COG3023	N-Acetylmuramoyl-L-alanine amidase
G4273_RS14935	COG1126	abc transporter atp-binding protein
G4273_RS14940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4273_RS14945	COG4215	(ABC) transporter
G4273_RS14950	COG4160	amino acid transport
G4273_RS14955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4273_RS14970	COG1177	transmembrane transport
G4273_RS14975	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4273_RS14980	COG3842	ATPase activity
G4273_RS14985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G4273_RS15000	COG0778	Nitroreductase
G4273_RS15010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4273_RS15025	COG3226	Transcriptional regulator
G4273_RS15030	COG0738	Major facilitator superfamily
G4273_RS15035	COG0561	phosphatase activity
G4273_RS15045	COG2814	Major facilitator Superfamily
G4273_RS15050	COG0671	phosphoesterase, PA-phosphatase related
G4273_RS15055	COG1349	DNA-binding transcription factor activity
G4273_RS15060	COG1686	Belongs to the peptidase S11 family
G4273_RS15065	COG0625	glutathione transferase activity
G4273_RS15070	COG2133	pyrroloquinoline quinone binding
G4273_RS15090	COG2200	EAL domain
G4273_RS15115	COG1446	asparaginase
G4273_RS15120	COG0303	'Molybdopterin
G4273_RS15125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4273_RS15130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4273_RS15135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4273_RS15140	COG1882	Formate acetyltransferase
G4273_RS15145	COG0561	phosphatase activity
G4273_RS15150	COG0488	(ABC) transporter
G4273_RS15155	COG1376	ErfK ybiS ycfS ynhG family protein
G4273_RS15160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G4273_RS15165	COG1321	iron dependent repressor
G4273_RS15175	COG2194	sulfuric ester hydrolase activity
G4273_RS15180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G4273_RS15190	COG5006	permease, DMT superfamily
G4273_RS15200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4273_RS15205	COG0765	amino acid transport
G4273_RS15210	COG1126	abc transporter atp-binding protein
G4273_RS15215	COG0668	transmembrane transport
G4273_RS15240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4273_RS15250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4273_RS15255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4273_RS15260	COG1199	ATP-dependent helicase activity
G4273_RS15270	COG0513	Belongs to the DEAD box helicase family
G4273_RS15275	COG1309	transcriptional regulator
G4273_RS15285	COG1131	(ABC) transporter
G4273_RS15290	COG0842	Transport permease protein
G4273_RS15295	COG0842	Transport permease protein
G4273_RS15305	COG3568	Endonuclease Exonuclease Phosphatase
G4273_RS15310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4273_RS15315	COG0392	lysyltransferase activity
G4273_RS15320	COG0670	Belongs to the BI1 family
G4273_RS15325	COG0670	Belongs to the BI1 family
G4273_RS15330	COG0314	molybdopterin synthase activity
G4273_RS15335	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G4273_RS15345	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4273_RS15355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4273_RS15365	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G4273_RS15370	COG2226	methyltransferase
G4273_RS15375	COG0156	8-amino-7-oxononanoate synthase activity
G4273_RS15385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4273_RS15395	COG1881	PFAM PEBP family protein
G4273_RS15400	COG4677	pectinesterase activity
G4273_RS15405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4273_RS15410	COG0471	metal ion transport
G4273_RS15415	COG2828	Protein conserved in bacteria
G4273_RS15420	COG0583	DNA-binding transcription factor activity
G4273_RS15430	COG0561	phosphatase activity
G4273_RS15435	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G4273_RS15440	COG4149	molybdate abc transporter
G4273_RS15445	COG0725	ABC transporter, periplasmic molybdate-binding protein
G4273_RS15455	COG3585	molybdate ion transport
G4273_RS15455	COG2005	Transcriptional regulator
G4273_RS15460	COG1119	ATPase activity
G4273_RS15465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4273_RS15470	COG1085	galactose-1-phosphate uridylyltransferase
G4273_RS15480	COG2017	converts alpha-aldose to the beta-anomer
G4273_RS15490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4273_RS15500	COG1230	cation diffusion facilitator family transporter
G4273_RS15505	COG3201	nicotinamide mononucleotide transporter
G4273_RS15510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G4273_RS15550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
G4273_RS15555	COG2885	chlorophyll binding
G4273_RS15565	COG3064	Membrane
G4273_RS15570	COG0848	biopolymer transport protein
G4273_RS15575	COG0811	peptide transport
G4273_RS15580	COG0824	Thioesterase
G4273_RS15585	COG3790	cyd operon protein YbgE
G4273_RS15590	COG4890	Cyd operon protein YbgT
G4273_RS15595	COG1294	oxidase, subunit
G4273_RS15600	COG1271	oxidase subunit
G4273_RS15610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4273_RS15620	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4273_RS15625	COG0567	Dehydrogenase, E1 component
G4273_RS15630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4273_RS15635	COG1053	succinate dehydrogenase
G4273_RS15640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G4273_RS15645	COG2009	succinate dehydrogenase
G4273_RS15655	COG0372	Belongs to the citrate synthase family
G4273_RS15665	COG3180	Ammonia monooxygenase
G4273_RS15675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G4273_RS15680	COG1984	allophanate hydrolase subunit 2
G4273_RS15685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G4273_RS15690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G4273_RS15700	COG0415	Belongs to the DNA photolyase family
G4273_RS15705	COG3272	Protein of unknown function (DUF1722)
G4273_RS15735	COG2205	protein histidine kinase activity
G4273_RS15740	COG0745	RESPONSE REGULATOR receiver
G4273_RS15750	COG1982	Orn Lys Arg decarboxylase major
G4273_RS15755	COG0531	amino acid
G4273_RS15760	COG0033	Phosphoglucomutase
G4273_RS15765	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
G4273_RS15770	COG0596	Alpha beta hydrolase
G4273_RS15780	COG0716	FMN binding
G4273_RS15790	COG0735	belongs to the Fur family
G4273_RS15810	COG1349	DNA-binding transcription factor activity
G4273_RS15815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4273_RS15820	COG3395	kinase activity
G4273_RS15825	COG1454	alcohol dehydrogenase
G4273_RS15830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4273_RS15835	COG0861	Integral membrane protein TerC family
G4273_RS15855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G4273_RS15975	COG2369	cell adhesion
G4273_RS15985	COG4373	Mu-like prophage FluMu protein gp28
G4273_RS16070	COG3267	Type II secretory pathway component ExeA
G4273_RS16070	COG3409	Peptidoglycan-binding domain 1 protein
G4273_RS16110	COG4382	Mu-like prophage protein Gp16
G4273_RS16120	COG1263	PTS System
G4273_RS16120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS16120	COG2190	(PTS) system
G4273_RS16130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4273_RS16135	COG1940	carbohydrate kinase activity
G4273_RS16135	COG1846	Transcriptional regulator
G4273_RS16140	COG0647	UMP catabolic process
G4273_RS16145	COG0367	asparagine synthase
G4273_RS16185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4273_RS16195	COG1702	phosphate starvation-inducible protein PhoH
G4273_RS16205	COG4535	Mg2 and Co2 transporter CorC
G4273_RS16210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G4273_RS16220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4273_RS16225	COG0765	amino acid transport
G4273_RS16230	COG0765	amino acid transport
G4273_RS16235	COG1126	abc transporter atp-binding protein
G4273_RS16245	COG2888	peptidyl-tyrosine sulfation
G4273_RS16260	COG1466	dna polymerase III delta subunit
G4273_RS16270	COG0406	alpha-ribazole phosphatase activity
G4273_RS16275	COG0799	negative regulation of ribosome biogenesis
G4273_RS16285	COG0768	penicillin binding
G4273_RS16290	COG0772	Belongs to the SEDS family
G4273_RS16295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4273_RS16325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4273_RS16330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4273_RS16350	COG3069	C4-dicarboxylate transmembrane transporter activity
G4273_RS16355	COG4565	transcriptional regulatory protein
G4273_RS16360	COG3290	protein histidine kinase activity
G4273_RS16365	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
G4273_RS16375	COG2301	Belongs to the HpcH HpaI aldolase family
G4273_RS16380	COG3051	citrate lyase alpha subunit
G4273_RS16395	COG0471	metal ion transport
G4273_RS16400	COG3719	Belongs to the RNase T2 family
G4273_RS16405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4273_RS16410	COG0589	response to stress
G4273_RS16415	COG3634	alkyl hydroperoxide reductase activity
G4273_RS16420	COG0450	alkyl hydroperoxide reductase
G4273_RS16425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4273_RS16430	COG0583	DNA-binding transcription factor activity
G4273_RS16435	COG3969	phosphoadenosine phosphosulfate
G4273_RS16440	COG1475	DNA binding
G4273_RS16450	COG0371	Dehydrogenase
G4273_RS16455	COG2879	small protein
G4273_RS16460	COG1966	Carbon starvation protein
G4273_RS16465	COG2050	protein possibly involved in aromatic compounds catabolism
G4273_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS16475	COG1535	isochorismatase
G4273_RS16475	COG3433	isochorismatase activity
G4273_RS16480	COG1021	2,3-dihydroxybenzoate-AMP ligase
G4273_RS16485	COG1169	isochorismate synthase
G4273_RS16490	COG4592	Periplasmic binding protein
G4273_RS16500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4273_RS16505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4273_RS16510	COG1120	ATPase activity
G4273_RS16515	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
G4273_RS16520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4273_RS16520	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G4273_RS16525	COG3251	PFAM MbtH domain protein
G4273_RS16530	COG2382	esterase
G4273_RS16535	COG4771	TonB-dependent receptor
G4273_RS16540	COG2977	Belongs to the P-Pant transferase superfamily
G4273_RS16560	COG2315	Protein conserved in bacteria
G4273_RS16565	COG0778	Nitroreductase
G4273_RS16570	COG0668	transmembrane transport
G4273_RS16575	COG1113	amino acid transport
G4273_RS16580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4273_RS16585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4273_RS16590	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4273_RS16595	COG1538	Outer membrane efflux protein
G4273_RS16600	COG0745	RESPONSE REGULATOR receiver
G4273_RS16605	COG5002	protein histidine kinase activity
G4273_RS16610	COG1215	transferase activity, transferring glycosyl groups
G4273_RS16615	COG4783	chaperone-mediated protein folding
G4273_RS16625	COG4571	Outer membrane protease
G4273_RS16630	COG0500	methyltransferase
G4273_RS16660	COG2501	S4 domain
G4273_RS16665	COG1988	membrane-bound metal-dependent
G4273_RS16675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4273_RS16690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G4273_RS16695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G4273_RS16700	COG0549	Belongs to the carbamate kinase family
G4273_RS16710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4273_RS16715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4273_RS16720	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4273_RS16725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4273_RS16730	COG3257	ureidoglycine aminohydrolase activity
G4273_RS16735	COG1929	Belongs to the glycerate kinase type-1 family
G4273_RS16740	COG2233	PERMEase
G4273_RS16750	COG1953	Uracil, thiamine, allantoin
G4273_RS16755	COG2084	Dehydrogenase
G4273_RS16760	COG3622	Belongs to the hyi family
G4273_RS16765	COG3960	tartronate-semialdehyde synthase activity
G4273_RS16770	COG1414	Transcriptional regulator
G4273_RS16790	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G4273_RS16795	COG4181	ATPase activity
G4273_RS16800	COG2755	lipolytic protein G-D-S-L family
G4273_RS16805	COG0300	oxidoreductase activity
G4273_RS16810	COG3118	belongs to the thioredoxin family
G4273_RS16815	COG0390	transport system, permease component
G4273_RS16820	COG4619	ABC transporter
G4273_RS16825	COG0330	HflC and HflK could
G4273_RS16830	COG1585	Membrane protein implicated in regulation of membrane protease activity
G4273_RS16855	COG0789	Transcriptional regulator
G4273_RS16860	COG0531	amino acid
G4273_RS16865	COG2066	Belongs to the glutaminase family
G4273_RS16870	COG2217	Heavy metal translocating P-type atpase
G4273_RS16875	COG3735	TraB family
G4273_RS16880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4273_RS16885	COG0737	Belongs to the 5'-nucleotidase family
G4273_RS16890	COG2223	nitrite transmembrane transporter activity
G4273_RS16895	COG4651	solute:proton antiporter activity
G4273_RS16895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4273_RS16900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS16935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4273_RS16945	COG2832	Protein of unknown function (DUF454)
G4273_RS16950	COG3923	Primosomal replication protein n
G4273_RS16960	COG3264	Mechanosensitive ion channel
G4273_RS16960	COG1196	nuclear chromosome segregation
G4273_RS16965	COG1309	transcriptional regulator
G4273_RS16970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4273_RS16975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4273_RS16990	COG0110	maltose O-acetyltransferase activity
G4273_RS17000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4273_RS17005	COG5507	3-demethylubiquinone-9 3-methyltransferase
G4273_RS17015	COG3695	enzyme binding
G4273_RS17020	COG3126	Type III secretion system lipoprotein chaperone (YscW)
G4273_RS17025	COG1946	Acyl-CoA thioesterase
G4273_RS17030	COG0004	ammonium transporteR
G4273_RS17035	COG0347	Belongs to the P(II) protein family
G4273_RS17040	COG1132	(ABC) transporter
G4273_RS17045	COG1132	(ABC) transporter
G4273_RS17050	COG1522	sequence-specific DNA binding
G4273_RS17060	COG4533	DNA binding
G4273_RS17070	COG0824	Thioesterase
G4273_RS17075	COG1555	photosystem II stabilization
G4273_RS17080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4273_RS17085	COG0776	regulation of translation
G4273_RS17090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4273_RS17110	COG0271	Belongs to the BolA IbaG family
G4273_RS17115	COG3056	Lipoprotein
G4273_RS17120	COG2223	nitrite transmembrane transporter activity
G4273_RS17125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4273_RS17130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4273_RS17135	COG1845	cytochrome c oxidase, subunit III
G4273_RS17140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G4273_RS17150	COG2814	Major facilitator Superfamily
G4273_RS17160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G4273_RS17165	COG0693	protein deglycase activity
G4273_RS17180	COG0142	geranyltranstransferase activity
G4273_RS17190	COG0667	Aldo Keto reductase
G4273_RS17195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4273_RS17200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G4273_RS17215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4273_RS17215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4273_RS17225	COG4238	major outer membrane lipoprotein
G4273_RS17230	COG3248	Nucleoside-binding outer membrane protein
G4273_RS17235	COG1403	HNH endonuclease
G4273_RS17240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4273_RS17245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4273_RS17250	COG1862	Preprotein translocase
G4273_RS17270	COG0366	Alpha amylase catalytic
G4273_RS17275	COG1113	amino acid transport
G4273_RS17280	COG1114	Component of the transport system for branched-chain amino acids
G4273_RS17285	COG5002	protein histidine kinase activity
G4273_RS17290	COG0745	RESPONSE REGULATOR receiver
G4273_RS17295	COG0420	3'-5' exonuclease activity
G4273_RS17300	COG0419	ATPase involved in DNA repair
G4273_RS17305	COG2814	Major facilitator Superfamily
G4273_RS17310	COG1940	carbohydrate kinase activity
G4273_RS17335	COG4126	flavin adenine dinucleotide binding
G4273_RS17355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4273_RS17360	COG3706	GGDEF domain
G4273_RS17370	COG1785	Belongs to the alkaline phosphatase family
G4273_RS17385	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4273_RS17405	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
G4273_RS17410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4273_RS17415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4273_RS17420	COG3468	outer membrane autotransporter barrel domain protein
G4273_RS17425	COG0113	porphobilinogen synthase activity
G4273_RS17430	COG2175	clavaminate synthase activity
G4273_RS17435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4273_RS17445	COG4521	taurine ABC transporter
G4273_RS17450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4273_RS17455	COG1215	transferase activity, transferring glycosyl groups
G4273_RS17485	COG3122	Protein conserved in bacteria
G4273_RS17495	COG1609	Transcriptional regulator
G4273_RS17500	COG3250	beta-galactosidase activity
G4273_RS17505	COG2223	nitrite transmembrane transporter activity
G4273_RS17510	COG0110	maltose O-acetyltransferase activity
G4273_RS17515	COG0402	S-adenosylhomocysteine deaminase activity
G4273_RS17520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G4273_RS17525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4273_RS17530	COG2079	MmgE PrpD family protein
G4273_RS17535	COG0372	Belongs to the citrate synthase family
G4273_RS17540	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G4273_RS17545	COG3829	transcription factor binding
G4273_RS17555	COG1280	lysine exporter protein (LysE YggA)
G4273_RS17565	COG1064	alcohol dehydrogenase
G4273_RS17570	COG0402	S-adenosylhomocysteine deaminase activity
G4273_RS17575	COG0549	Belongs to the carbamate kinase family
G4273_RS17580	COG1304	FMN binding
G4273_RS17585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4273_RS17595	COG0666	response to abiotic stimulus
G4273_RS17605	COG0583	DNA-binding transcription factor activity
G4273_RS17610	COG2771	luxR family
G4273_RS17610	COG2200	EAL domain
G4273_RS17615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G4273_RS17630	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G4273_RS17635	COG0582	viral genome integration into host DNA
G4273_RS17640	COG2771	luxR family
G4273_RS17640	COG2200	EAL domain
G4273_RS17655	COG3468	outer membrane autotransporter barrel domain protein
G4273_RS17665	COG1556	Lactate utilization protein
G4273_RS17670	COG1139	Iron-sulfur cluster binding protein
G4273_RS17675	COG0247	lactate metabolic process
G4273_RS17680	COG2207	Transcriptional regulator
G4273_RS17685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4273_RS17695	COG3059	membrane
G4273_RS17700	COG0656	L-ascorbic acid biosynthetic process
G4273_RS17705	COG3708	Transcriptional regulator
G4273_RS17705	COG2207	Transcriptional regulator
G4273_RS17710	COG1388	LysM domain
G4273_RS17715	COG0656	L-ascorbic acid biosynthetic process
G4273_RS17720	COG0667	Aldo Keto reductase
G4273_RS17730	COG0583	DNA-binding transcription factor activity
G4273_RS17735	COG1073	alpha beta
G4273_RS17740	COG1902	pentaerythritol trinitrate reductase activity
G4273_RS17795	COG0727	PFAM Uncharacterised protein family (UPF0153)
G4273_RS17805	COG3477	response to acidic pH
G4273_RS17830	COG0582	viral genome integration into host DNA
G4273_RS17920	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G4273_RS17940	COG2195	Cleaves the N-terminal amino acid of tripeptides
G4273_RS17945	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G4273_RS17950	COG1690	Belongs to the RtcB family
G4273_RS17955	COG0454	-acetyltransferase
G4273_RS17985	COG0791	NLP P60 protein
G4273_RS17990	COG3034	peptidoglycan biosynthetic process
G4273_RS17995	COG0121	glutamine amidotransferase
G4273_RS18005	COG1960	acyl-CoA dehydrogenase activity
G4273_RS18015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4273_RS18055	COG3501	Rhs element vgr protein
G4273_RS18150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4273_RS18160	COG2226	methyltransferase
G4273_RS18170	COG0741	lytic transglycosylase activity
G4273_RS18170	COG1388	LysM domain
G4273_RS18175	COG2226	methyltransferase
G4273_RS18185	COG0583	DNA-binding transcription factor activity
G4273_RS18190	COG0656	L-ascorbic acid biosynthetic process
G4273_RS18225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G4273_RS18235	COG2011	ABC-type metal ion transport system permease component
G4273_RS18240	COG1464	Belongs to the NlpA lipoprotein family
G4273_RS18250	COG1720	tRNA m6t6A37 methyltransferase activity
G4273_RS18260	COG0791	NLP P60 protein
G4273_RS18265	COG3015	lipoprotein NlpE involved in copper resistance
G4273_RS18270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G4273_RS18275	COG4681	YaeQ
G4273_RS18285	COG4568	rho-dependent transcription termination
G4273_RS18290	COG0037	tRNA processing
G4273_RS18295	COG0346	lactoylglutathione lyase activity
G4273_RS18310	COG0587	DNA-directed DNA polymerase activity
G4273_RS18335	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4273_RS18340	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
G4273_RS18350	COG0750	zinc metalloprotease
G4273_RS18355	COG0575	Belongs to the CDS family
G4273_RS18360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4273_RS18365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4273_RS18390	COG0024	Methionine aminopeptidase
G4273_RS18415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4273_RS18430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4273_RS18435	COG2860	membrane
G4273_RS18460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4273_RS18465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4273_RS18470	COG1120	ATPase activity
G4273_RS18475	COG4774	siderophore transport
G4273_RS18480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4273_RS18485	COG1643	Atp-dependent helicase
G4273_RS18490	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G4273_RS18500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4273_RS18505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4273_RS18510	COG0617	tRNA 3'-terminal CCA addition
G4273_RS18515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4273_RS18520	COG3539	Fimbrial protein
G4273_RS18525	COG3121	Chaperone
G4273_RS18530	COG3188	usher protein
G4273_RS18535	COG3539	Fimbrial protein
G4273_RS18540	COG3539	Fimbrial protein
G4273_RS18545	COG3539	Fimbrial protein
G4273_RS18550	COG3539	Fimbrial protein
G4273_RS18560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G4273_RS18565	COG5464	transposase or invertase
G4273_RS18575	COG0726	polysaccharide deacetylase
G4273_RS18580	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS18585	COG0842	Transport permease protein
G4273_RS18590	COG1131	(ABC) transporter
G4273_RS18595	COG0288	reversible hydration of carbon dioxide
G4273_RS18600	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G4273_RS18605	COG4993	Dehydrogenase
G4273_RS18610	COG2132	Multicopper oxidase
G4273_RS18635	COG1049	propionate catabolic process, 2-methylcitrate cycle
G4273_RS18640	COG3064	Membrane
G4273_RS18645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4273_RS18650	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4273_RS18655	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G4273_RS18660	COG2186	Transcriptional regulator
G4273_RS18685	COG3157	Type VI secretion system effector, Hcp
G4273_RS18690	COG1113	amino acid transport
G4273_RS18695	COG3725	Membrane protein required for beta-lactamase induction
G4273_RS18700	COG3023	N-Acetylmuramoyl-L-alanine amidase
G4273_RS18705	COG0157	Belongs to the NadC ModD family
G4273_RS18710	COG4969	Belongs to the N-Me-Phe pilin family
G4273_RS18715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4273_RS18720	COG1459	type II secretion system
G4273_RS18735	COG0237	dephospho-CoA kinase activity
G4273_RS18750	COG0494	nUDIX hydrolase
G4273_RS18770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4273_RS18775	COG0849	cell division
G4273_RS18780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4273_RS18785	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4273_RS18800	COG0772	Belongs to the SEDS family
G4273_RS18815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4273_RS18820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4273_RS18825	COG0768	penicillin binding
G4273_RS18830	COG3116	cell division
G4273_RS18845	COG1609	Transcriptional regulator
G4273_RS18855	COG0440	acetolactate synthase activity
G4273_RS18860	COG0028	Belongs to the TPP enzyme family
G4273_RS18870	COG0583	DNA-binding transcription factor activity
G4273_RS18910	COG4143	(ABC) transporter
G4273_RS18915	COG1178	ABC-type Fe3 transport system permease component
G4273_RS18925	COG0586	Pfam SNARE associated Golgi protein
G4273_RS18930	COG4977	sequence-specific DNA binding
G4273_RS18945	COG0235	Class ii aldolase
G4273_RS18950	COG0417	DNA replication proofreading
G4273_RS18960	COG0564	pseudouridine synthase activity
G4273_RS18965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G4273_RS18975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4273_RS18980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4273_RS19010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G4273_RS19025	COG2271	Major facilitator Superfamily
G4273_RS19030	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G4273_RS19035	COG0644	oxidoreductase
G4273_RS19085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4273_RS19090	COG0505	Belongs to the CarA family
G4273_RS19115	COG1047	Peptidyl-prolyl cis-trans
G4273_RS19130	COG0196	riboflavin kinase activity
G4273_RS19145	COG0583	DNA-binding transcription factor activity
G4273_RS19160	COG3119	arylsulfatase activity
G4273_RS19190	COG4735	regulation of single-species biofilm formation
G4273_RS19195	COG1584	GPR1 FUN34 yaaH family protein
G4273_RS19200	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4273_RS19210	COG1115	amino acid carrier protein
G4273_RS19225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4273_RS19235	COG0460	homoserine dehydrogenase
G4273_RS19235	COG0527	aspartate kinase activity
G4273_RS19245	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
G4273_RS19255	COG0745	RESPONSE REGULATOR receiver
G4273_RS19260	COG4452	Inner membrane protein CreD
G4273_RS19265	COG2205	protein histidine kinase activity
G4273_RS19270	COG0745	RESPONSE REGULATOR receiver
G4273_RS19275	COG3045	CreA protein
G4273_RS19280	COG3708	Transcriptional regulator
G4273_RS19280	COG2207	Transcriptional regulator
G4273_RS19300	COG0741	lytic transglycosylase activity
G4273_RS19305	COG0488	(ABC) transporter
G4273_RS19315	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G4273_RS19320	COG3172	ATPase kinase involved in NAD metabolism
G4273_RS19320	COG1056	cytidyltransferase-related domain
G4273_RS19325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G4273_RS19330	COG0560	Phosphoserine phosphatase
G4273_RS19335	COG3726	membrane protein affecting hemolysin expression
G4273_RS19345	COG3550	peptidyl-serine autophosphorylation
G4273_RS19370	COG1328	CTP reductase activity
G4273_RS19375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4273_RS19380	COG0084	hydrolase, TatD family'
G4273_RS19385	COG4667	esterase of the alpha-beta hydrolase superfamily
G4273_RS19395	COG2823	Periplasmic or secreted lipoprotein
G4273_RS19405	COG1011	Hydrolase
G4273_RS19410	COG0456	acetyltransferase
G4273_RS19415	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
G4273_RS19445	COG4114	ferric iron reductase
G4273_RS19450	COG2197	response regulator
G4273_RS19455	COG2197	response regulator
G4273_RS19460	COG2966	Psort location CytoplasmicMembrane, score
G4273_RS19475	COG1484	DNA-dependent DNA replication
G4273_RS19490	COG1063	alcohol dehydrogenase
G4273_RS19495	COG1802	Transcriptional regulator
G4273_RS19500	COG2271	Major facilitator Superfamily
G4273_RS19505	COG0840	transmembrane signaling receptor activity
G4273_RS19510	COG1966	Carbon starvation protein
G4273_RS19515	COG2879	small protein
G4273_RS19520	COG0523	cobalamin synthesis protein
G4273_RS19535	COG1715	Restriction endonuclease
G4273_RS19540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4273_RS19545	COG0732	type I restriction modification DNA specificity domain
G4273_RS19550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4273_RS19565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4273_RS19575	COG2733	membrane
G4273_RS19580	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
G4273_RS19585	COG1924	4 iron, 4 sulfur cluster binding
G4273_RS19600	COG0477	Major facilitator Superfamily
G4273_RS19610	COG3366	ferrous iron transmembrane transporter activity
G4273_RS19615	COG0700	Nucleoside recognition
G4273_RS19620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4273_RS19625	COG0583	DNA-binding transcription factor activity
G4273_RS19640	COG2186	Transcriptional regulator
G4273_RS19645	COG0246	Mannitol dehydrogenase
G4273_RS19655	COG2610	gluconate transmembrane transporter activity
G4273_RS19660	COG3539	Fimbrial protein
G4273_RS19665	COG3539	Fimbrial protein
G4273_RS19670	COG3539	Fimbrial protein
G4273_RS19675	COG3188	usher protein
G4273_RS19680	COG3121	Chaperone
G4273_RS19685	COG3539	Fimbrial protein
G4273_RS19695	COG4974	Belongs to the 'phage' integrase family
G4273_RS19700	COG0582	viral genome integration into host DNA
G4273_RS19705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G4273_RS19710	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
G4273_RS19735	COG3153	acetyltransferase
G4273_RS19740	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G4273_RS19745	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G4273_RS19755	COG1363	Peptidase, m42
G4273_RS19760	COG3414	Phosphotransferase system galactitol-specific IIB component
G4273_RS19765	COG3775	system Galactitol-specific IIC component
G4273_RS19770	COG0434	BtpA family
G4273_RS19775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS19780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4273_RS19785	COG1349	DNA-binding transcription factor activity
G4273_RS19790	COG1414	Transcriptional regulator
G4273_RS19795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4273_RS19800	COG0129	dihydroxy-acid dehydratase activity
G4273_RS19805	COG2610	gluconate transmembrane transporter activity
G4273_RS19810	COG2390	Transcriptional regulator
G4273_RS19840	COG2003	Belongs to the UPF0758 family
G4273_RS19865	COG2378	regulation of single-species biofilm formation
G4273_RS19870	COG3596	GTP binding
G4273_RS19905	COG1757	Na H antiporter
G4273_RS19910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4273_RS19950	COG1454	alcohol dehydrogenase
G4273_RS19950	COG1012	belongs to the aldehyde dehydrogenase family
G4273_RS19960	COG1012	belongs to the aldehyde dehydrogenase family
G4273_RS19960	COG1454	alcohol dehydrogenase
G4273_RS19965	COG1882	Formate acetyltransferase
G4273_RS19970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4273_RS19980	COG4869	propanediol catabolic process
G4273_RS19995	COG2076	Multidrug Resistance protein
G4273_RS20005	COG0583	DNA-binding transcription factor activity
G4273_RS20010	COG2610	gluconate transmembrane transporter activity
G4273_RS20105	COG5002	protein histidine kinase activity
G4273_RS20110	COG0745	RESPONSE REGULATOR receiver
G4273_RS20120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4273_RS20140	COG2274	protein secretion by the type I secretion system
G4273_RS20175	COG3436	PFAM IS66 Orf2 family protein
G4273_RS20180	COG4372	Transposase
G4273_RS20185	COG1309	transcriptional regulator
G4273_RS20195	COG1304	FMN binding
G4273_RS20200	COG2259	Doxx family
G4273_RS20305	COG4584	PFAM Integrase catalytic
G4273_RS20310	COG1484	DNA-dependent DNA replication
G4273_RS20320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4273_RS20320	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
G4273_RS20325	COG0582	viral genome integration into host DNA
G4273_RS20335	COG1064	alcohol dehydrogenase
G4273_RS20340	COG3265	gluconokinase activity
G4273_RS20345	COG1063	alcohol dehydrogenase
G4273_RS20350	COG1028	Short-chain dehydrogenase reductase Sdr
G4273_RS20355	COG2610	gluconate transmembrane transporter activity
G4273_RS20360	COG1609	Transcriptional regulator
G4273_RS20365	COG0433	COG0433 Predicted ATPase
G4273_RS20370	COG0795	lipopolysaccharide-transporting ATPase activity
G4273_RS20375	COG0795	lipopolysaccharide-transporting ATPase activity
G4273_RS20385	COG2927	DNA polymerase III (CHI subunit)
G4273_RS20390	COG0525	valine-tRNA ligase activity
G4273_RS20400	COG0456	acetyltransferase
G4273_RS20405	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
G4273_RS20410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4273_RS20415	COG2731	YhcH YjgK YiaL family protein
G4273_RS20425	COG0549	Belongs to the carbamate kinase family
G4273_RS20430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4273_RS20435	COG1288	antiporter activity
G4273_RS20440	COG1438	arginine binding
G4273_RS20460	COG0251	oxidation-reduction process
G4273_RS20465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4273_RS20475	COG1609	Transcriptional regulator
G4273_RS20480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS20480	COG1263	PTS System
G4273_RS20485	COG0366	Alpha amylase catalytic
G4273_RS20490	COG1328	CTP reductase activity
G4273_RS20495	COG0602	queuosine metabolic process
G4273_RS20500	COG3783	Cytochrome b(562)
G4273_RS20505	COG0312	modulator of DNA gyrase
G4273_RS20510	COG3028	Belongs to the UPF0307 family
G4273_RS20515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4273_RS20525	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4273_RS20530	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4273_RS20535	COG1129	ABC transporter
G4273_RS20540	COG1879	ABC-type sugar transport system periplasmic component
G4273_RS20545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G4273_RS20550	COG2105	PFAM AIG2 family protein
G4273_RS20555	COG2911	Protein conserved in bacteria
G4273_RS20560	COG0729	surface antigen
G4273_RS20570	COG1253	flavin adenine dinucleotide binding
G4273_RS20580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
G4273_RS20585	COG1218	3'(2'),5'-bisphosphate nucleotidase
G4273_RS20590	COG0737	Belongs to the 5'-nucleotidase family
G4273_RS20595	COG1733	regulation of RNA biosynthetic process
G4273_RS20600	COG0702	epimerase
G4273_RS20605	COG0697	spore germination
G4273_RS20615	COG1113	amino acid transport
G4273_RS20620	COG0545	Peptidyl-prolyl cis-trans isomerase
G4273_RS20625	COG3061	Opacity-associated protein A
G4273_RS20630	COG1309	transcriptional regulator
G4273_RS20645	COG1024	Enoyl-CoA hydratase
G4273_RS20650	COG4670	ketone body catabolic process
G4273_RS20660	COG2271	Major facilitator Superfamily
G4273_RS20680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4273_RS20720	COG3414	Phosphotransferase system galactitol-specific IIB component
G4273_RS20725	COG3037	sugar-specific permease SgaT UlaA
G4273_RS20740	COG1073	alpha beta
G4273_RS20745	COG3650	response to hydrogen peroxide
G4273_RS20755	COG1960	acyl-CoA dehydrogenase activity
G4273_RS20760	COG0754	glutathionylspermidine amidase activity
G4273_RS20765	COG5463	Belongs to the UPF0441 family
G4273_RS20770	COG3766	membrane
G4273_RS20780	COG1842	Phage shock protein A
G4273_RS20785	COG3789	protein conserved in bacteria
G4273_RS20790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4273_RS20795	COG0557	exoribonuclease II activity
G4273_RS20810	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
G4273_RS20815	COG0330	HflC and HflK could
G4273_RS20820	COG0330	HflC and HflK could
G4273_RS20825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4273_RS20845	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4273_RS20850	COG0802	atpase or kinase
G4273_RS20855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G4273_RS20855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4273_RS20860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4273_RS20900	COG3264	Mechanosensitive ion channel
G4273_RS20900	COG1511	domain protein
G4273_RS20905	COG0531	amino acid
G4273_RS20915	COG1053	succinate dehydrogenase
G4273_RS20920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4273_RS20935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4273_RS20940	COG3040	lipid binding
G4273_RS20945	COG2076	Multidrug Resistance protein
G4273_RS20950	COG5510	response to toxic substance
G4273_RS20955	COG5510	response to toxic substance
G4273_RS20965	COG1509	lysine 2,3-aminomutase activity
G4273_RS20990	COG0531	amino acid
G4273_RS20995	COG3030	protein affecting phage T7 exclusion by the F plasmid
G4273_RS21000	COG1027	Aspartate ammonia-lyase
G4273_RS21005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G4273_RS21015	COG4232	protein-disulfide reductase activity
G4273_RS21020	COG1309	transcriptional regulator
G4273_RS21030	COG0582	viral genome integration into host DNA
G4273_RS21035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4273_RS21035	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
G4273_RS21040	COG2194	sulfuric ester hydrolase activity
G4273_RS21190	COG3969	phosphoadenosine phosphosulfate
G4273_RS21215	COG4771	TonB-dependent receptor
G4273_RS21240	COG3596	GTP binding
G4273_RS21245	COG2378	regulation of single-species biofilm formation
G4273_RS21270	COG2003	Belongs to the UPF0758 family
G4273_RS21305	COG1484	DNA-dependent DNA replication
G4273_RS21310	COG4584	PFAM Integrase catalytic
G4273_RS21320	COG2771	luxR family
G4273_RS21320	COG2200	EAL domain
G4273_RS21325	COG3710	Transcriptional regulator
G4273_RS21330	COG0531	amino acid
G4273_RS21335	COG1982	Orn Lys Arg decarboxylase major
G4273_RS21340	COG3104	oligopeptide transport
G4273_RS21345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4273_RS21360	COG2388	GCN5-related N-acetyl-transferase
G4273_RS21365	COG3592	Divergent 4Fe-4S mono-cluster
G4273_RS21370	COG3290	protein histidine kinase activity
G4273_RS21375	COG4565	transcriptional regulatory protein
G4273_RS21380	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G4273_RS21385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G4273_RS21385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4273_RS21390	COG3647	Membrane
G4273_RS21395	COG1486	melibiose metabolic process
G4273_RS21400	COG2169	Transcriptional regulator
G4273_RS21405	COG1982	Orn Lys Arg decarboxylase major
G4273_RS21410	COG2207	Transcriptional regulator
G4273_RS21415	COG0531	amino acid
G4273_RS21420	COG2194	sulfuric ester hydrolase activity
G4273_RS21425	COG0745	RESPONSE REGULATOR receiver
G4273_RS21430	COG0642	Histidine kinase
G4273_RS21440	COG0477	Major facilitator Superfamily
G4273_RS21455	COG2824	Alkylphosphonate utilization operon protein PhnA
G4273_RS21460	COG2764	glyoxalase bleomycin resistance protein dioxygenase
G4273_RS21470	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G4273_RS21475	COG3639	organic phosphonate transmembrane transporter activity
G4273_RS21480	COG2188	Transcriptional regulator
G4273_RS21485	COG3624	Phosphonate C-P lyase system protein PhnG
G4273_RS21490	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
G4273_RS21495	COG3626	phosphonate metabolism
G4273_RS21500	COG3627	carbon phosphorus lyase activity
G4273_RS21505	COG4107	phosphonate C-P lyase system protein PhnK
G4273_RS21510	COG4778	phosphonate C-P lyase system protein PhnL
G4273_RS21515	COG3454	Phosphonate metabolism
G4273_RS21520	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G4273_RS21525	COG0456	acetyltransferase
G4273_RS21530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G4273_RS21540	COG0698	ribose 5-phosphate isomerase
G4273_RS21545	COG1737	Transcriptional regulator
G4273_RS21550	COG1879	ABC-type sugar transport system periplasmic component
G4273_RS21555	COG1129	ABC transporter
G4273_RS21560	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4273_RS21565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4273_RS21570	COG1940	carbohydrate kinase activity
G4273_RS21575	COG2015	COG2015, Alkyl sulfatase and related hydrolases
G4273_RS21585	COG1566	PFAM secretion protein HlyD family protein
G4273_RS21590	COG1289	transmembrane transporter activity
G4273_RS21595	COG1538	Outer membrane efflux protein
G4273_RS21610	COG0601	transmembrane transport
G4273_RS21620	COG0444	Belongs to the ABC transporter superfamily
G4273_RS21625	COG4608	Belongs to the ABC transporter superfamily
G4273_RS21630	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
G4273_RS21635	COG1301	dicarboxylic acid transport
G4273_RS21640	COG4235	cytochrome complex assembly
G4273_RS21645	COG3088	subunit of a heme lyase
G4273_RS21650	COG1138	Cytochrome C-type biogenesis protein
G4273_RS21655	COG3301	Polysulphide reductase, NrfD
G4273_RS21660	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS21665	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
G4273_RS21675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4273_RS21680	COG3162	membrane
G4273_RS21690	COG1346	cytolysis
G4273_RS21695	COG1380	Effector of murein hydrolase LrgA
G4273_RS21700	COG0583	DNA-binding transcription factor activity
G4273_RS21705	COG0025	NhaP-type Na H and K H
G4273_RS21710	COG2252	PERMEase
G4273_RS21715	COG0789	Transcriptional regulator
G4273_RS21720	COG2207	Transcriptional regulator
G4273_RS21725	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G4273_RS21735	COG0629	single-stranded DNA binding
G4273_RS21740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4273_RS21745	COG2315	Protein conserved in bacteria
G4273_RS21750	COG0432	Pfam Uncharacterised protein family UPF0047
G4273_RS21755	COG3700	Belongs to the class B bacterial acid phosphatase family
G4273_RS21765	COG2204	response regulator
G4273_RS21770	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G4273_RS21775	COG0471	metal ion transport
G4273_RS21780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4273_RS21785	COG0045	succinate-CoA ligase (ADP-forming) activity
G4273_RS21790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4273_RS21800	COG0567	Dehydrogenase, E1 component
G4273_RS21805	COG1448	Aminotransferase
G4273_RS21810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4273_RS21815	COG0305	Participates in initiation and elongation during chromosome replication
G4273_RS21820	COG1609	Transcriptional regulator
G4273_RS21830	COG1024	Enoyl-CoA hydratase
G4273_RS21835	COG0477	Major facilitator Superfamily
G4273_RS21840	COG1053	succinate dehydrogenase
G4273_RS21845	COG0604	alcohol dehydrogenase
G4273_RS21855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4273_RS21860	COG0735	belongs to the Fur family
G4273_RS21865	COG3237	CsbD-like
G4273_RS21870	COG0534	Mate efflux family protein
G4273_RS21880	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G4273_RS21910	COG3842	ATPase activity
G4273_RS21915	COG2182	Extracellular solute-binding protein
G4273_RS21920	COG1175	transmembrane transport
G4273_RS21925	COG3833	ABC-type maltose transport systems, permease component
G4273_RS21940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4273_RS21965	COG0527	aspartate kinase activity
G4273_RS21975	COG1187	pseudouridine synthase activity
G4273_RS22020	COG1283	sodium-dependent phosphate transmembrane transporter activity
G4273_RS22035	COG0646	methionine synthase
G4273_RS22035	COG1410	methionine synthase
G4273_RS22040	COG1414	Transcriptional regulator
G4273_RS22050	COG2224	Isocitrate lyase
G4273_RS22055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G4273_RS22065	COG0456	acetyltransferase
G4273_RS22100	COG0151	Belongs to the GarS family
G4273_RS22105	COG2204	response regulator
G4273_RS22110	COG4191	Histidine kinase
G4273_RS22115	COG3678	ATP-independent chaperone mediated protein folding
G4273_RS22130	COG3068	Protein conserved in bacteria
G4273_RS22155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G4273_RS22165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4273_RS22170	COG2104	thiamine diphosphate biosynthetic process
G4273_RS22180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4273_RS22215	COG0250	Participates in transcription elongation, termination and antitermination
G4273_RS22220	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4273_RS22255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G4273_RS22255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G4273_RS22260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4273_RS22290	COG4206	TonB-dependent receptor
G4273_RS22310	COG0477	Major facilitator Superfamily
G4273_RS22315	COG1473	amidohydrolase
G4273_RS22325	COG0583	DNA-binding transcription factor activity
G4273_RS22330	COG2271	Major facilitator Superfamily
G4273_RS22335	COG4948	Mandelate Racemase Muconate Lactonizing
G4273_RS22345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4273_RS22350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G4273_RS22365	COG2194	sulfuric ester hydrolase activity
G4273_RS22370	COG2207	Transcriptional regulator
G4273_RS22375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS22380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
G4273_RS22385	COG1882	Formate acetyltransferase
G4273_RS22390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS22395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4273_RS22400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4273_RS22400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS22400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4273_RS22405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4273_RS22410	COG0371	Dehydrogenase
G4273_RS22415	COG3738	Protein conserved in bacteria
G4273_RS22420	COG0697	spore germination
G4273_RS22430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G4273_RS22435	COG0737	Belongs to the 5'-nucleotidase family
G4273_RS22445	COG0737	Belongs to the 5'-nucleotidase family
G4273_RS22450	COG0737	Belongs to the 5'-nucleotidase family
G4273_RS22460	COG0527	aspartate kinase activity
G4273_RS22460	COG0460	homoserine dehydrogenase
G4273_RS22465	COG0626	cystathionine gamma-synthase activity
G4273_RS22475	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
G4273_RS22485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4273_RS22490	COG1609	Transcriptional regulator
G4273_RS22495	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4273_RS22510	COG1575	Belongs to the MenA family. Type 1 subfamily
G4273_RS22525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4273_RS22535	COG1494	fructose-1,6-bisphosphatase
G4273_RS22545	COG0589	response to stress
G4273_RS22550	COG3691	Protein conserved in bacteria
G4273_RS22555	COG3152	Membrane
G4273_RS22575	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G4273_RS22590	COG3678	ATP-independent chaperone mediated protein folding
G4273_RS22595	COG0745	RESPONSE REGULATOR receiver
G4273_RS22600	COG2205	protein histidine kinase activity
G4273_RS22605	COG2258	MOSC domain
G4273_RS22615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4273_RS22675	COG0437	4 iron, 4 sulfur cluster binding
G4273_RS22680	COG2864	formate dehydrogenase
G4273_RS22695	COG4680	protein conserved in bacteria
G4273_RS22705	COG0456	acetyltransferase
G4273_RS22720	COG1011	Hydrolase
G4273_RS22730	COG0477	Major facilitator Superfamily
G4273_RS22740	COG1063	alcohol dehydrogenase
G4273_RS22745	COG3684	Belongs to the aldolase LacD family
G4273_RS22750	COG2084	Dehydrogenase
G4273_RS22755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS22760	COG1349	DNA-binding transcription factor activity
G4273_RS22765	COG2271	Major facilitator Superfamily
G4273_RS22770	COG1082	Xylose isomerase domain protein TIM barrel
G4273_RS22775	COG2188	Transcriptional regulator
G4273_RS22785	COG0174	glutamine synthetase
G4273_RS22790	COG3852	Histidine kinase
G4273_RS22795	COG2204	response regulator
G4273_RS22805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4273_RS22820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4273_RS22820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4273_RS22825	COG0204	Acyl-transferase
G4273_RS22830	COG5339	Protein conserved in bacteria
G4273_RS22835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4273_RS22840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G4273_RS22845	COG3084	Protein conserved in bacteria
G4273_RS22850	COG0746	molybdenum cofactor guanylyltransferase activity
G4273_RS22855	COG1763	Mo-molybdopterin cofactor biosynthetic process
G4273_RS22885	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
G4273_RS22890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G4273_RS22895	COG1739	Uncharacterized protein family UPF0029
G4273_RS22905	COG1024	Enoyl-CoA hydratase
G4273_RS22905	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4273_RS22915	COG0543	2 iron, 2 sulfur cluster binding
G4273_RS22920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G4273_RS22935	COG0805	protein transport
G4273_RS22945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4273_RS22955	COG3165	ubiquinone biosynthetic process from chorismate
G4273_RS22965	COG1322	Protein conserved in bacteria
G4273_RS22970	COG1414	Transcriptional regulator
G4273_RS22975	COG3734	2-keto-3-deoxy-galactonokinase
G4273_RS22980	COG0800	Aldolase
G4273_RS23000	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
G4273_RS23005	COG0412	Dienelactone hydrolase
G4273_RS23010	COG1335	isochorismatase
G4273_RS23020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4273_RS23025	COG1304	FMN binding
G4273_RS23030	COG0549	Belongs to the carbamate kinase family
G4273_RS23040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G4273_RS23045	COG0583	DNA-binding transcription factor activity
G4273_RS23050	COG1737	Transcriptional regulator
G4273_RS23055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4273_RS23060	COG1263	PTS System
G4273_RS23060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS23060	COG2190	(PTS) system
G4273_RS23070	COG3157	Type VI secretion system effector, Hcp
G4273_RS23075	COG3157	Type VI secretion system effector, Hcp
G4273_RS23090	COG0583	DNA-binding transcription factor activity
G4273_RS23095	COG0697	spore germination
G4273_RS23100	COG0561	phosphatase activity
G4273_RS23105	COG2267	carboxylic ester hydrolase activity
G4273_RS23110	COG1280	lysine exporter protein (LysE YggA)
G4273_RS23115	COG1280	lysine exporter protein (LysE YggA)
G4273_RS23120	COG0514	ATP-dependent DNA helicase (RecQ)
G4273_RS23125	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
G4273_RS23130	COG2050	protein possibly involved in aromatic compounds catabolism
G4273_RS23135	COG2962	Rard protein
G4273_RS23150	COG0598	Magnesium transport protein CorA
G4273_RS23155	COG3698	Phosphodiester glycosidase
G4273_RS23160	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
G4273_RS23165	COG0210	DNA helicase
G4273_RS23170	COG1011	Hydrolase
G4273_RS23180	COG3159	Protein conserved in bacteria
G4273_RS23190	COG5567	small periplasmic lipoprotein
G4273_RS23205	COG3072	Adenylate cyclase
G4273_RS23215	COG1587	Uroporphyrinogen-III synthase
G4273_RS23220	COG2959	enzyme of heme biosynthesis
G4273_RS23225	COG3071	HemY protein
G4273_RS23230	COG3119	arylsulfatase activity
G4273_RS23235	COG0641	radical SAM
G4273_RS23260	COG1113	amino acid transport
G4273_RS23280	COG2244	polysaccharide biosynthetic process
G4273_RS23285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4273_RS23290	COG0456	acetyltransferase
G4273_RS23295	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G4273_RS23300	COG1088	dTDP-glucose 4,6-dehydratase activity
G4273_RS23305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G4273_RS23310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G4273_RS23315	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
G4273_RS23320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4273_RS23325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G4273_RS23335	COG3118	belongs to the thioredoxin family
G4273_RS23350	COG0210	DNA helicase
G4273_RS23355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4273_RS23365	COG0583	DNA-binding transcription factor activity
G4273_RS23370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4273_RS23375	COG0129	dihydroxy-acid dehydratase activity
G4273_RS23380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4273_RS23385	COG3978	acetolactate synthase activity
G4273_RS23405	COG0606	chelatase, subunit chli
G4273_RS23410	COG3085	chromosome segregation
G4273_RS23450	COG2186	Transcriptional regulator
G4273_RS23455	COG0477	Major facilitator Superfamily
G4273_RS23460	COG1609	Transcriptional regulator
G4273_RS23465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4273_RS23470	COG1879	ABC-type sugar transport system periplasmic component
G4273_RS23475	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4273_RS23480	COG1129	ABC transporter
G4273_RS23510	COG1522	sequence-specific DNA binding
G4273_RS23515	COG0716	FMN binding
G4273_RS23530	COG3312	ion transport
G4273_RS23585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4273_RS23590	COG0573	inorganic phosphate transmembrane transporter activity
G4273_RS23595	COG0581	inorganic phosphate transmembrane transporter activity
G4273_RS23600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4273_RS23605	COG0704	Plays a role in the regulation of phosphate uptake
G4273_RS23610	COG3711	transcriptional antiterminator
G4273_RS23615	COG2190	(PTS) system
G4273_RS23615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4273_RS23615	COG1263	PTS System
G4273_RS23620	COG2723	6-phospho-beta-galactosidase activity
G4273_RS23625	COG4580	involved in the transport of maltose and maltodextrins
G4273_RS23630	COG2382	esterase
G4273_RS23635	COG0363	glucosamine-6-phosphate deaminase activity
G4273_RS23645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4273_RS23650	COG2252	PERMEase
G4273_RS23655	COG0431	NADPH-dependent FMN reductase
G4273_RS23660	COG2091	lysine biosynthetic process via aminoadipic acid
G4273_RS23675	COG0814	amino acid
G4273_RS23875	COG1475	DNA binding