locus-tag	class	description
C4E05_RS00590	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C4E05_RS00695	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C4E05_RS00725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4E05_RS00730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E05_RS00790	COG2826	transposase and inactivated derivatives, IS30 family
C4E05_RS00795	COG3039	Transposase
C4E05_RS00815	COG0673	inositol 2-dehydrogenase activity
C4E05_RS00855	COG1192	Involved in chromosome partitioning
C4E05_RS00895	COG0484	heat shock protein binding
C4E05_RS00960	COG2963	transposase activity
C4E05_RS01040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4E05_RS01050	COG1111	helicase
C4E05_RS01050	COG1205	dead DEAH box helicase
C4E05_RS01055	COG0210	DNA helicase
C4E05_RS01135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4E05_RS01180	COG0697	spore germination
C4E05_RS01430	COG2948	multi-organism process
C4E05_RS01435	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
C4E05_RS01460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E05_RS01650	COG0697	spore germination
C4E05_RS01960	COG1475	DNA binding
C4E05_RS02130	COG2271	Major facilitator Superfamily
C4E05_RS02135	COG1063	alcohol dehydrogenase
C4E05_RS02140	COG2186	Transcriptional regulator
C4E05_RS02230	COG0592	DNA-directed DNA polymerase activity
C4E05_RS02240	COG0187	DNA topoisomerase II activity
C4E05_RS02245	COG3753	Protein conserved in bacteria
C4E05_RS02250	COG0561	phosphatase activity
C4E05_RS02260	COG2186	Transcriptional regulator
C4E05_RS02265	COG3734	2-keto-3-deoxy-galactonokinase
C4E05_RS02270	COG0800	Aldolase
C4E05_RS02280	COG2271	Major facilitator Superfamily
C4E05_RS02285	COG0644	oxidoreductase
C4E05_RS02290	COG0823	Involved in the tonB-independent uptake of proteins
C4E05_RS02295	COG5645	(Lipo)protein
C4E05_RS02315	COG2188	Transcriptional regulator
C4E05_RS02330	COG2207	Transcriptional regulator
C4E05_RS02335	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4E05_RS02340	COG3119	arylsulfatase activity
C4E05_RS02350	COG2149	membrane
C4E05_RS02360	COG0641	radical SAM
C4E05_RS02365	COG2814	Major facilitator Superfamily
C4E05_RS02385	COG0028	Belongs to the TPP enzyme family
C4E05_RS02390	COG0440	acetolactate synthase activity
C4E05_RS02395	COG2197	response regulator
C4E05_RS02400	COG3851	Histidine kinase
C4E05_RS02405	COG2271	Major facilitator Superfamily
C4E05_RS02410	COG2271	Major facilitator Superfamily
C4E05_RS02420	COG2252	PERMEase
C4E05_RS02440	COG1464	Belongs to the NlpA lipoprotein family
C4E05_RS02445	COG0697	spore germination
C4E05_RS02450	COG2814	Major facilitator Superfamily
C4E05_RS02465	COG2211	Major facilitator Superfamily
C4E05_RS02470	COG1501	Belongs to the glycosyl hydrolase 31 family
C4E05_RS02475	COG2982	Protein involved in outer membrane biogenesis
C4E05_RS02480	COG2233	PERMEase
C4E05_RS02485	COG0786	glutamate:sodium symporter activity
C4E05_RS02490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4E05_RS02495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4E05_RS02500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4E05_RS02510	COG0194	GDP metabolic process
C4E05_RS02520	COG2860	membrane
C4E05_RS02525	COG3645	SOS response
C4E05_RS02535	COG1561	YicC-like family, N-terminal region
C4E05_RS02560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4E05_RS02590	COG1519	Transferase
C4E05_RS02595	COG0859	PFAM glycosyl transferase family 9
C4E05_RS02600	COG0438	transferase activity, transferring glycosyl groups
C4E05_RS02605	COG0515	serine threonine protein kinase
C4E05_RS02610	COG1442	glycosyl transferase family 8
C4E05_RS02615	COG0438	transferase activity, transferring glycosyl groups
C4E05_RS02620	COG1442	glycosyl transferase family 8
C4E05_RS02625	COG1442	glycosyl transferase family 8
C4E05_RS02630	COG3642	lipopolysaccharide core region biosynthetic process
C4E05_RS02650	COG0859	PFAM glycosyl transferase family 9
C4E05_RS02655	COG0859	PFAM glycosyl transferase family 9
C4E05_RS02665	COG0156	8-amino-7-oxononanoate synthase activity
C4E05_RS02675	COG1216	Glycosyl transferase, family 2
C4E05_RS02680	COG2861	carbohydrate metabolic process
C4E05_RS02685	COG4942	peptidase
C4E05_RS02695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4E05_RS02700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4E05_RS02715	COG1045	serine acetyltransferase
C4E05_RS02720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C4E05_RS02730	COG2186	Transcriptional regulator
C4E05_RS02735	COG1620	l-lactate permease
C4E05_RS02750	COG3722	fumarate hydratase activity
C4E05_RS02760	COG2213	PTS system mannitol-specific
C4E05_RS02760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS02770	COG1566	PFAM secretion protein HlyD family protein
C4E05_RS02790	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4E05_RS02805	COG1413	lyase activity
C4E05_RS02810	COG3209	COG3209 Rhs family protein
C4E05_RS02815	COG0625	glutathione transferase activity
C4E05_RS02825	COG3276	selenocysteine insertion sequence binding
C4E05_RS02830	COG1454	alcohol dehydrogenase
C4E05_RS02835	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS02850	COG1566	PFAM secretion protein HlyD family protein
C4E05_RS02855	COG0583	DNA-binding transcription factor activity
C4E05_RS02860	COG3713	MltA-interacting MipA family protein
C4E05_RS02870	COG0235	Class ii aldolase
C4E05_RS02875	COG3623	hexulose-6-phosphate isomerase
C4E05_RS02880	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C4E05_RS02885	COG1070	Carbohydrate kinase
C4E05_RS02890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C4E05_RS02895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C4E05_RS02900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C4E05_RS02905	COG2731	YhcH YjgK YiaL family protein
C4E05_RS02915	COG1414	Transcriptional regulator
C4E05_RS02920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS02925	COG3977	Valine--pyruvate aminotransferase
C4E05_RS02930	COG0366	Alpha amylase catalytic
C4E05_RS02935	COG2992	FlgJ-related protein
C4E05_RS02940	COG2207	Transcriptional regulator
C4E05_RS02940	COG1609	Transcriptional regulator
C4E05_RS02945	COG4214	carbohydrate transport
C4E05_RS02950	COG1129	ABC transporter
C4E05_RS02955	COG4213	ABC transporter substrate-binding protein
C4E05_RS02965	COG1070	Carbohydrate kinase
C4E05_RS02970	COG4682	membrane
C4E05_RS02975	COG4682	membrane
C4E05_RS02980	COG3274	enterobacterial common antigen metabolic process
C4E05_RS03010	COG1278	Cold shock
C4E05_RS03015	COG2944	sequence-specific DNA binding
C4E05_RS03030	COG2885	chlorophyll binding
C4E05_RS03035	COG0243	molybdopterin cofactor binding
C4E05_RS03040	COG0456	acetyltransferase
C4E05_RS03045	COG2818	Glycosylase
C4E05_RS03050	COG5571	outer membrane autotransporter
C4E05_RS03055	COG2223	nitrite transmembrane transporter activity
C4E05_RS03060	COG2194	sulfuric ester hydrolase activity
C4E05_RS03070	COG0747	negative chemotaxis
C4E05_RS03080	COG0601	transmembrane transport
C4E05_RS03085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E05_RS03090	COG0444	Belongs to the ABC transporter superfamily
C4E05_RS03095	COG4608	Belongs to the ABC transporter superfamily
C4E05_RS03100	COG0814	amino acid
C4E05_RS03115	COG2194	sulfuric ester hydrolase activity
C4E05_RS03140	COG1215	transferase activity, transferring glycosyl groups
C4E05_RS03145	COG1215	transferase activity, transferring glycosyl groups
C4E05_RS03150	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C4E05_RS03155	COG0457	Tetratricopeptide repeat
C4E05_RS03155	COG3118	belongs to the thioredoxin family
C4E05_RS03160	COG2199	diguanylate cyclase activity
C4E05_RS03160	COG2200	EAL domain
C4E05_RS03170	COG0612	Peptidase, M16
C4E05_RS03175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS03180	COG2200	EAL domain
C4E05_RS03185	COG2982	Protein involved in outer membrane biogenesis
C4E05_RS03190	COG0477	Major facilitator Superfamily
C4E05_RS03195	COG1295	ribonuclease BN
C4E05_RS03200	COG0583	DNA-binding transcription factor activity
C4E05_RS03205	COG2197	response regulator
C4E05_RS03215	COG1858	cytochrome C peroxidase
C4E05_RS03220	COG0076	glutamate decarboxylase activity
C4E05_RS03225	COG2207	Transcriptional regulator
C4E05_RS03230	COG2207	Transcriptional regulator
C4E05_RS03235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4E05_RS03240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4E05_RS03250	COG2771	luxR family
C4E05_RS03255	COG3247	response to pH
C4E05_RS03285	COG2197	response regulator
C4E05_RS03290	COG3065	identical protein binding
C4E05_RS03300	COG1393	Belongs to the ArsC family
C4E05_RS03305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4E05_RS03310	COG0640	Transcriptional regulator
C4E05_RS03320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E05_RS03325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4E05_RS03330	COG0339	signal peptide processing
C4E05_RS03340	COG3104	oligopeptide transport
C4E05_RS03345	COG0589	response to stress
C4E05_RS03355	COG0306	phosphate transporter
C4E05_RS03360	COG2081	HI0933 family
C4E05_RS03380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4E05_RS03385	COG0842	Transport permease protein
C4E05_RS03385	COG1129	ABC transporter
C4E05_RS03390	COG0842	Transport permease protein
C4E05_RS03395	COG5433	transposase activity
C4E05_RS03400	COG1413	lyase activity
C4E05_RS03410	COG3209	COG3209 Rhs family protein
C4E05_RS03420	COG1124	(ABC) transporter
C4E05_RS03425	COG0444	Belongs to the ABC transporter superfamily
C4E05_RS03430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E05_RS03435	COG0601	transmembrane transport
C4E05_RS03440	COG0747	negative chemotaxis
C4E05_RS03445	COG2091	lysine biosynthetic process via aminoadipic acid
C4E05_RS03450	COG0628	permease
C4E05_RS03455	COG0477	Major facilitator Superfamily
C4E05_RS03465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C4E05_RS03475	COG2217	Heavy metal translocating P-type atpase
C4E05_RS03480	COG3714	YhhN family
C4E05_RS03490	COG3776	membrane
C4E05_RS03495	COG0742	ribosomal rna small subunit methyltransferase
C4E05_RS03500	COG0552	protein localization to endoplasmic reticulum
C4E05_RS03505	COG2884	Cell division ATP-binding protein ftsE
C4E05_RS03510	COG2177	Part of the ABC transporter FtsEX involved in
C4E05_RS03515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4E05_RS03520	COG0683	leucine binding
C4E05_RS03525	COG0456	acetyltransferase
C4E05_RS03530	COG0683	leucine binding
C4E05_RS03535	COG0559	Belongs to the binding-protein-dependent transport system permease family
C4E05_RS03540	COG4177	L-phenylalanine transmembrane transporter activity
C4E05_RS03545	COG0411	ABC transporter
C4E05_RS03550	COG0410	ABC transporter
C4E05_RS03555	COG1653	transport
C4E05_RS03560	COG1175	transmembrane transport
C4E05_RS03565	COG0395	ABC-type sugar transport system, permease component
C4E05_RS03570	COG3842	ATPase activity
C4E05_RS03575	COG0584	glycerophosphoryl diester phosphodiesterase
C4E05_RS03585	COG0405	Gamma-glutamyltransferase
C4E05_RS03610	COG3157	Type VI secretion system effector, Hcp
C4E05_RS03615	COG1247	-acetyltransferase
C4E05_RS03620	COG0673	inositol 2-dehydrogenase activity
C4E05_RS03625	COG1741	Belongs to the pirin family
C4E05_RS03630	COG1609	Transcriptional regulator
C4E05_RS03635	COG3265	gluconokinase activity
C4E05_RS03640	COG2610	gluconate transmembrane transporter activity
C4E05_RS03645	COG2095	MarC family integral membrane protein
C4E05_RS03650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4E05_RS03675	COG0058	SHG alpha-glucan phosphorylase activity
C4E05_RS03685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4E05_RS03700	COG1349	DNA-binding transcription factor activity
C4E05_RS03705	COG4650	regulator
C4E05_RS03710	COG1690	Belongs to the RtcB family
C4E05_RS03725	COG0058	SHG alpha-glucan phosphorylase activity
C4E05_RS03730	COG1640	4-alpha-glucanotransferase
C4E05_RS03735	COG2610	gluconate transmembrane transporter activity
C4E05_RS03745	COG1040	competence protein
C4E05_RS03755	COG5464	transposase or invertase
C4E05_RS03765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C4E05_RS03770	COG1918	ferrous iron import across plasma membrane
C4E05_RS03775	COG2183	response to ionizing radiation
C4E05_RS03780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4E05_RS03800	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C4E05_RS03810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4E05_RS03815	COG1011	Hydrolase
C4E05_RS03825	COG0494	nUDIX hydrolase
C4E05_RS03830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C4E05_RS03835	COG4972	Pilus assembly protein
C4E05_RS03840	COG3166	PFAM Fimbrial assembly family protein
C4E05_RS03855	COG4796	Type ii and iii secretion system protein
C4E05_RS03870	COG3266	domain, Protein
C4E05_RS03875	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C4E05_RS03880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4E05_RS03885	COG0546	phosphoglycolate phosphatase activity
C4E05_RS03890	COG0180	Tryptophanyl-tRNA synthetase
C4E05_RS03900	COG2188	Transcriptional regulator
C4E05_RS03910	COG3457	Alanine racemase
C4E05_RS03915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C4E05_RS03920	COG1735	metal-dependent hydrolase with the TIM-barrel fold
C4E05_RS03935	COG0626	cystathionine gamma-synthase activity
C4E05_RS03940	COG2188	Transcriptional regulator
C4E05_RS03945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS03950	COG1082	Xylose isomerase domain protein TIM barrel
C4E05_RS03955	COG2222	sugar isomerase
C4E05_RS03960	COG0531	amino acid
C4E05_RS03975	COG2116	formate transmembrane transporter activity
C4E05_RS03980	COG2146	nitrite reductase [NAD(P)H] activity
C4E05_RS03985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4E05_RS03995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4E05_RS04005	COG2184	nucleotidyltransferase activity
C4E05_RS04010	COG0512	Glutamine amidotransferase of anthranilate synthase
C4E05_RS04015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4E05_RS04020	COG1289	transmembrane transporter activity
C4E05_RS04025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4E05_RS04030	COG1765	OsmC-like protein
C4E05_RS04035	COG3954	Phosphoribulokinase
C4E05_RS04045	COG0429	hydrolase of the alpha beta-hydrolase fold
C4E05_RS04050	COG0488	(ABC) transporter
C4E05_RS04065	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4E05_RS04070	COG1047	Peptidyl-prolyl cis-trans
C4E05_RS04080	COG0545	Peptidyl-prolyl cis-trans isomerase
C4E05_RS04085	COG2964	Protein conserved in bacteria
C4E05_RS04125	COG3979	chitinase
C4E05_RS04130	COG2906	2 iron, 2 sulfur cluster binding
C4E05_RS04135	COG2193	ferroxidase activity
C4E05_RS04140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4E05_RS04145	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C4E05_RS04150	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C4E05_RS04155	COG3156	type II secretion system protein K
C4E05_RS04160	COG4795	General secretion pathway protein
C4E05_RS04165	COG2165	general secretion pathway protein
C4E05_RS04170	COG2165	general secretion pathway protein
C4E05_RS04175	COG2165	general secretion pathway protein
C4E05_RS04180	COG1459	type II secretion system
C4E05_RS04185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4E05_RS04190	COG1450	Type ii and iii secretion system protein
C4E05_RS04195	COG3031	protein transport across the cell outer membrane
C4E05_RS04200	COG3267	Type II secretory pathway component ExeA
C4E05_RS04200	COG3409	Peptidoglycan-binding domain 1 protein
C4E05_RS04225	COG0089	rRNA binding
C4E05_RS04315	COG0201	protein transport
C4E05_RS04355	COG0789	Transcriptional regulator
C4E05_RS04360	COG3036	rescue of stalled ribosome
C4E05_RS04370	COG0569	domain protein
C4E05_RS04390	COG0758	DNA mediated transformation
C4E05_RS04400	COG0551	DNA topoisomerase type I activity
C4E05_RS04420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4E05_RS04465	COG1126	abc transporter atp-binding protein
C4E05_RS04470	COG0765	amino acid transport
C4E05_RS04475	COG4597	amino acid ABC transporter
C4E05_RS04480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS04490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4E05_RS04510	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C4E05_RS04520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4E05_RS04530	COG4145	pantothenate transmembrane transporter activity
C4E05_RS04535	COG3924	membrane
C4E05_RS04540	COG0439	Biotin carboxylase
C4E05_RS04545	COG0511	ligase activity, forming carbon-carbon bonds
C4E05_RS04550	COG0604	alcohol dehydrogenase
C4E05_RS04555	COG2200	EAL domain
C4E05_RS04555	COG2199	diguanylate cyclase activity
C4E05_RS04560	COG1077	Cell shape determining protein MreB Mrl
C4E05_RS04565	COG1792	Involved in formation and maintenance of cell shape
C4E05_RS04570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C4E05_RS04575	COG0424	maF-like protein
C4E05_RS04580	COG1530	ribonuclease E activity
C4E05_RS04585	COG3164	Protein of unknown function
C4E05_RS04590	COG0312	modulator of DNA gyrase
C4E05_RS04595	COG0583	DNA-binding transcription factor activity
C4E05_RS04615	COG2732	(Barnase) inhibitor
C4E05_RS04635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4E05_RS04640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4E05_RS04645	COG3105	Protein conserved in bacteria
C4E05_RS04650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4E05_RS04665	COG0625	glutathione transferase activity
C4E05_RS04670	COG2969	positive regulation of protein catabolic process
C4E05_RS04675	COG3069	C4-dicarboxylate transmembrane transporter activity
C4E05_RS04705	COG2731	YhcH YjgK YiaL family protein
C4E05_RS04710	COG4804	nuclease activity
C4E05_RS04725	COG3344	reverse transcriptase
C4E05_RS04740	COG3539	Fimbrial protein
C4E05_RS04750	COG3188	usher protein
C4E05_RS04755	COG3121	Chaperone
C4E05_RS04760	COG3539	Fimbrial protein
C4E05_RS04765	COG0493	'glutamate synthase
C4E05_RS04770	COG0067	glutamate synthase
C4E05_RS04770	COG0070	glutamate synthase
C4E05_RS04770	COG0069	glutamate synthase activity
C4E05_RS04775	COG1242	4 iron, 4 sulfur cluster binding
C4E05_RS04780	COG0784	Response regulator, receiver
C4E05_RS04780	COG2198	Histidine kinase
C4E05_RS04780	COG5002	protein histidine kinase activity
C4E05_RS04785	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C4E05_RS04795	COG0515	serine threonine protein kinase
C4E05_RS04800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS04815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4E05_RS04820	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C4E05_RS04825	COG1137	ATPase activity
C4E05_RS04830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4E05_RS04835	COG3117	lipopolysaccharide transmembrane transporter activity
C4E05_RS04840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4E05_RS04845	COG0517	IMP dehydrogenase activity
C4E05_RS04845	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4E05_RS04850	COG0530	calcium, potassium:sodium antiporter activity
C4E05_RS04855	COG1127	ABC transporter
C4E05_RS04860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4E05_RS04865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4E05_RS04870	COG2854	intermembrane phospholipid transfer
C4E05_RS04875	COG3113	response to antibiotic
C4E05_RS04880	COG5007	Belongs to the BolA IbaG family
C4E05_RS04890	COG3423	Transcriptional regulator
C4E05_RS04895	COG0142	geranyltranstransferase activity
C4E05_RS04910	COG0697	spore germination
C4E05_RS04920	COG2027	D-alanyl-D-alanine carboxypeptidase
C4E05_RS04925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4E05_RS04930	COG1534	Rna-binding protein
C4E05_RS04940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4E05_RS04945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4E05_RS04955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4E05_RS04965	COG2194	sulfuric ester hydrolase activity
C4E05_RS04985	COG0195	Participates in both transcription termination and antitermination
C4E05_RS05025	COG0513	Belongs to the DEAD box helicase family
C4E05_RS05030	COG0814	amino acid
C4E05_RS05035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4E05_RS05040	COG0826	peptidase U32
C4E05_RS05045	COG0826	peptidase U32
C4E05_RS05050	COG3154	lipid carrier protein
C4E05_RS05055	COG3153	acetyltransferase
C4E05_RS05070	COG0693	protein deglycase activity
C4E05_RS05075	COG0702	epimerase
C4E05_RS05080	COG0701	Predicted permease
C4E05_RS05085	COG2823	Periplasmic or secreted lipoprotein
C4E05_RS05100	COG3107	peptidoglycan biosynthetic process
C4E05_RS05105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C4E05_RS05110	COG3539	Fimbrial protein
C4E05_RS05115	COG3188	usher protein
C4E05_RS05120	COG3121	Chaperone
C4E05_RS05125	COG3539	Fimbrial protein
C4E05_RS05130	COG0363	glucosamine-6-phosphate deaminase activity
C4E05_RS05135	COG3716	PTS system mannose fructose sorbose family IID component
C4E05_RS05140	COG3715	PTS system
C4E05_RS05150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS05160	COG2222	sugar isomerase
C4E05_RS05165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4E05_RS05170	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS05175	COG3716	PTS system mannose fructose sorbose family IID component
C4E05_RS05185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS05195	COG1349	DNA-binding transcription factor activity
C4E05_RS05205	COG2002	toxin-antitoxin pair type II binding
C4E05_RS05210	COG2721	sulfolactate sulfo-lyase activity
C4E05_RS05215	COG2271	Major facilitator Superfamily
C4E05_RS05225	COG2084	Dehydrogenase
C4E05_RS05230	COG1929	Belongs to the glycerate kinase type-1 family
C4E05_RS05255	COG0583	DNA-binding transcription factor activity
C4E05_RS05260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4E05_RS05270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4E05_RS05275	COG1882	Formate acetyltransferase
C4E05_RS05280	COG0251	oxidation-reduction process
C4E05_RS05285	COG1760	l-serine dehydratase
C4E05_RS05290	COG0814	amino acid
C4E05_RS05305	COG1741	Belongs to the pirin family
C4E05_RS05310	COG0583	DNA-binding transcription factor activity
C4E05_RS05315	COG3152	Membrane
C4E05_RS05325	COG3152	Membrane
C4E05_RS05330	COG0435	Glutathione S-transferase
C4E05_RS05335	COG2259	Doxx family
C4E05_RS05345	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C4E05_RS05350	COG4575	ribosome binding
C4E05_RS05355	COG1422	Protein of unknown function (DUF1090)
C4E05_RS05365	COG0586	Pfam SNARE associated Golgi protein
C4E05_RS05370	COG2186	Transcriptional regulator
C4E05_RS05375	COG2271	Major facilitator Superfamily
C4E05_RS05385	COG2721	sulfolactate sulfo-lyase activity
C4E05_RS05395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C4E05_RS05400	COG0861	Integral membrane protein TerC family
C4E05_RS05405	COG0673	inositol 2-dehydrogenase activity
C4E05_RS05410	COG2949	membrane
C4E05_RS05415	COG1451	nucleotide metabolic process
C4E05_RS05425	COG4680	protein conserved in bacteria
C4E05_RS05430	COG5499	transcription regulator containing HTH domain
C4E05_RS05435	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4E05_RS05435	COG1902	pentaerythritol trinitrate reductase activity
C4E05_RS05440	COG3408	Glycogen debranching enzyme
C4E05_RS05440	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C4E05_RS05450	COG0531	amino acid
C4E05_RS05455	COG2731	YhcH YjgK YiaL family protein
C4E05_RS05460	COG3250	beta-galactosidase activity
C4E05_RS05465	COG1609	Transcriptional regulator
C4E05_RS05470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E05_RS05480	COG0840	transmembrane signaling receptor activity
C4E05_RS05485	COG1695	Transcriptional regulator
C4E05_RS05490	COG2375	cellular response to nickel ion
C4E05_RS05505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4E05_RS05510	COG0358	DNA primase activity
C4E05_RS05515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4E05_RS05525	COG0471	metal ion transport
C4E05_RS05530	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C4E05_RS05535	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4E05_RS05540	COG0583	DNA-binding transcription factor activity
C4E05_RS05550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4E05_RS05565	COG4991	sh3 domain protein
C4E05_RS05570	COG3025	triphosphatase activity
C4E05_RS05595	COG2268	Band 7 protein
C4E05_RS05600	COG1585	Membrane protein implicated in regulation of membrane protease activity
C4E05_RS05610	COG3539	Fimbrial protein
C4E05_RS05615	COG3121	Chaperone
C4E05_RS05620	COG3188	usher protein
C4E05_RS05635	COG3539	Fimbrial protein
C4E05_RS05640	COG2960	long-chain fatty acid transporting porin activity
C4E05_RS05655	COG3384	dioxygenase
C4E05_RS05660	COG0754	glutathionylspermidine amidase activity
C4E05_RS05670	COG1538	Outer membrane efflux protein
C4E05_RS05675	COG0494	nUDIX hydrolase
C4E05_RS05680	COG3151	Protein conserved in bacteria
C4E05_RS05685	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4E05_RS05690	COG3150	esterase
C4E05_RS05695	COG0187	DNA topoisomerase II activity
C4E05_RS05700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4E05_RS05705	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4E05_RS05715	COG0642	Histidine kinase
C4E05_RS05720	COG0745	RESPONSE REGULATOR receiver
C4E05_RS05725	COG3111	PFAM Bacterial OB fold (BOF) protein
C4E05_RS05730	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C4E05_RS05740	COG2944	sequence-specific DNA binding
C4E05_RS05745	COG4166	transmembrane transport
C4E05_RS05750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4E05_RS05755	COG0204	Acyl-transferase
C4E05_RS05760	COG2132	Multicopper oxidase
C4E05_RS05765	COG1032	radical SAM domain protein
C4E05_RS05770	COG4238	major outer membrane lipoprotein
C4E05_RS05780	COG0656	L-ascorbic acid biosynthetic process
C4E05_RS05785	COG1979	alcohol dehydrogenase
C4E05_RS05790	COG2207	Transcriptional regulator
C4E05_RS05795	COG0586	Pfam SNARE associated Golgi protein
C4E05_RS05800	COG0626	cystathionine gamma-synthase activity
C4E05_RS05805	COG0811	peptide transport
C4E05_RS05810	COG0848	biopolymer transport protein
C4E05_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS05825	COG0667	Aldo Keto reductase
C4E05_RS05840	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C4E05_RS05845	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS05850	COG5557	Pfam Polysulphide reductase, NrfD
C4E05_RS05855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C4E05_RS05860	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C4E05_RS05865	COG1773	rubredoxin
C4E05_RS05875	COG0298	carbon dioxide binding
C4E05_RS05880	COG0625	glutathione transferase activity
C4E05_RS05885	COG0754	glutathionylspermidine amidase activity
C4E05_RS05890	COG0306	phosphate transporter
C4E05_RS05895	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4E05_RS05900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4E05_RS05905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4E05_RS05910	COG2244	polysaccharide biosynthetic process
C4E05_RS05920	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C4E05_RS05925	COG0795	lipopolysaccharide-transporting ATPase activity
C4E05_RS05935	COG0156	8-amino-7-oxononanoate synthase activity
C4E05_RS05940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4E05_RS05950	COG0318	PFAM AMP-dependent synthetase and ligase
C4E05_RS05955	COG0456	acetyltransferase
C4E05_RS05960	COG2186	Transcriptional regulator
C4E05_RS05965	COG0277	FAD linked oxidase domain protein
C4E05_RS05970	COG0277	FAD linked oxidase domain protein
C4E05_RS05975	COG0247	lactate metabolic process
C4E05_RS05980	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C4E05_RS05985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4E05_RS05990	COG1620	l-lactate permease
C4E05_RS05995	COG3064	Membrane
C4E05_RS06000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4E05_RS06010	COG3031	protein transport across the cell outer membrane
C4E05_RS06025	COG1459	type II secretion system
C4E05_RS06030	COG2165	general secretion pathway protein
C4E05_RS06060	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C4E05_RS06095	COG2003	Belongs to the UPF0758 family
C4E05_RS06120	COG2378	regulation of single-species biofilm formation
C4E05_RS06125	COG3596	GTP binding
C4E05_RS06160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4E05_RS06165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS06170	COG2313	pseudouridylate synthase activity
C4E05_RS06175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C4E05_RS06180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS06180	COG1522	sequence-specific DNA binding
C4E05_RS06230	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4E05_RS06235	COG2207	Transcriptional regulator
C4E05_RS06240	COG2972	Histidine kinase
C4E05_RS06250	COG3344	reverse transcriptase
C4E05_RS06270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E05_RS06275	COG1882	Formate acetyltransferase
C4E05_RS06280	COG0693	protein deglycase activity
C4E05_RS06290	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS06325	COG4820	ethanolamine utilization protein (EutJ)
C4E05_RS06330	COG4869	propanediol catabolic process
C4E05_RS06385	COG3969	phosphoadenosine phosphosulfate
C4E05_RS06390	COG1475	DNA binding
C4E05_RS06410	COG1201	RNA secondary structure unwinding
C4E05_RS06435	COG2194	sulfuric ester hydrolase activity
C4E05_RS06440	COG0582	viral genome integration into host DNA
C4E05_RS06450	COG1811	Na channel or pump
C4E05_RS06455	COG1982	Orn Lys Arg decarboxylase major
C4E05_RS06460	COG2211	Major facilitator Superfamily
C4E05_RS06475	COG1194	a g-specific adenine glycosylase
C4E05_RS06485	COG3171	Protein conserved in bacteria
C4E05_RS06495	COG0252	asparaginase activity
C4E05_RS06505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4E05_RS06510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C4E05_RS06520	COG0762	integral membrane protein
C4E05_RS06525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4E05_RS06530	COG2805	Type II/IV secretion system protein
C4E05_RS06545	COG0189	ligase activity
C4E05_RS06550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4E05_RS06555	COG2356	endonuclease I
C4E05_RS06565	COG2814	Major facilitator Superfamily
C4E05_RS06580	COG1166	arginine decarboxylase activity
C4E05_RS06590	COG0501	Belongs to the peptidase M48B family
C4E05_RS06595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4E05_RS06600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS06605	COG2213	PTS system mannitol-specific
C4E05_RS06610	COG1063	alcohol dehydrogenase
C4E05_RS06615	COG1494	fructose-1,6-bisphosphatase
C4E05_RS06620	COG3722	fumarate hydratase activity
C4E05_RS06625	COG1072	(Pantothenic acid kinase))
C4E05_RS06640	COG0191	fructose-bisphosphate aldolase activity
C4E05_RS06645	COG0668	transmembrane transport
C4E05_RS06650	COG1279	arginine transmembrane transporter activity
C4E05_RS06655	COG2968	Membrane
C4E05_RS06660	COG0583	DNA-binding transcription factor activity
C4E05_RS06665	COG0427	acetyl-CoA hydrolase
C4E05_RS06670	COG1024	Enoyl-CoA hydratase
C4E05_RS06675	COG1703	isobutyryl-CoA mutase activity
C4E05_RS06680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4E05_RS06680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C4E05_RS06700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4E05_RS06710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4E05_RS06730	COG0006	proline dipeptidase activity
C4E05_RS06735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4E05_RS06740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4E05_RS06765	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS06770	COG2723	6-phospho-beta-galactosidase activity
C4E05_RS06780	COG1272	protein, Hemolysin III
C4E05_RS06790	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4E05_RS06800	COG0716	FMN binding
C4E05_RS06805	COG4974	Belongs to the 'phage' integrase family
C4E05_RS06810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4E05_RS06815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4E05_RS06825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4E05_RS06845	COG2233	PERMEase
C4E05_RS06850	COG0493	'glutamate synthase
C4E05_RS06850	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS06855	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS06860	COG2252	PERMEase
C4E05_RS06865	COG0402	S-adenosylhomocysteine deaminase activity
C4E05_RS06870	COG2233	PERMEase
C4E05_RS06875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E05_RS06875	COG2080	2 iron, 2 sulfur cluster binding
C4E05_RS06880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4E05_RS06885	COG0402	S-adenosylhomocysteine deaminase activity
C4E05_RS06890	COG0493	'glutamate synthase
C4E05_RS06890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS06895	COG2068	MobA-Related Protein
C4E05_RS06900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4E05_RS06905	COG3608	succinylglutamate desuccinylase aspartoacylase
C4E05_RS06905	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4E05_RS06910	COG0549	Belongs to the carbamate kinase family
C4E05_RS06920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E05_RS06925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4E05_RS06930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4E05_RS06935	COG3829	transcription factor binding
C4E05_RS06940	COG2080	2 iron, 2 sulfur cluster binding
C4E05_RS06945	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4E05_RS06950	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E05_RS06955	COG4942	peptidase
C4E05_RS06965	COG4974	Belongs to the 'phage' integrase family
C4E05_RS07000	COG3385	transposase activity
C4E05_RS07050	COG3039	Transposase
C4E05_RS07110	COG3710	Transcriptional regulator
C4E05_RS07110	COG0457	Tetratricopeptide repeat
C4E05_RS07115	COG0457	Tetratricopeptide repeat
C4E05_RS07140	COG3710	Transcriptional regulator
C4E05_RS07145	COG2771	luxR family
C4E05_RS07150	COG0814	amino acid
C4E05_RS07155	COG0183	Belongs to the thiolase family
C4E05_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS07170	COG2814	Major facilitator Superfamily
C4E05_RS07175	COG1794	racemase activity, acting on amino acids and derivatives
C4E05_RS07180	COG0583	DNA-binding transcription factor activity
C4E05_RS07190	COG1609	Transcriptional regulator
C4E05_RS07210	COG0667	Aldo Keto reductase
C4E05_RS07220	COG0861	Integral membrane protein TerC family
C4E05_RS07240	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C4E05_RS07255	COG2165	general secretion pathway protein
C4E05_RS07260	COG4795	General secretion pathway protein
C4E05_RS07270	COG4967	type IV pilus modification protein PilV
C4E05_RS07275	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4E05_RS07280	COG1025	Belongs to the peptidase M16 family
C4E05_RS07285	COG1074	ATP-dependent DNA helicase activity
C4E05_RS07290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4E05_RS07295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4E05_RS07295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4E05_RS07300	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E05_RS07320	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C4E05_RS07325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4E05_RS07330	COG2166	iron-sulfur cluster assembly
C4E05_RS07335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4E05_RS07345	COG0583	DNA-binding transcription factor activity
C4E05_RS07350	COG2363	Small membrane protein
C4E05_RS07360	COG1349	DNA-binding transcription factor activity
C4E05_RS07370	COG1070	Carbohydrate kinase
C4E05_RS07380	COG0738	Major facilitator superfamily
C4E05_RS07385	COG0235	Class ii aldolase
C4E05_RS07390	COG1454	alcohol dehydrogenase
C4E05_RS07400	COG1760	l-serine dehydratase
C4E05_RS07405	COG0814	amino acid
C4E05_RS07410	COG1611	Belongs to the LOG family
C4E05_RS07425	COG3098	single-species biofilm formation
C4E05_RS07430	COG0564	pseudouridine synthase activity
C4E05_RS07435	COG0716	FMN binding
C4E05_RS07440	COG2271	Major facilitator Superfamily
C4E05_RS07445	COG4948	Mandelate Racemase Muconate Lactonizing
C4E05_RS07450	COG4948	Mandelate Racemase Muconate Lactonizing
C4E05_RS07455	COG4999	Histidine kinase
C4E05_RS07455	COG3850	Histidine kinase
C4E05_RS07455	COG2205	protein histidine kinase activity
C4E05_RS07455	COG3437	response regulator, receiver
C4E05_RS07460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4E05_RS07465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4E05_RS07470	COG2336	PFAM SpoVT AbrB
C4E05_RS07475	COG2337	Toxic component of a toxin-antitoxin (TA) module
C4E05_RS07480	COG3956	TIGRFAM MazG family protein
C4E05_RS07495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4E05_RS07505	COG0602	queuosine metabolic process
C4E05_RS07510	COG1070	Carbohydrate kinase
C4E05_RS07515	COG2223	nitrite transmembrane transporter activity
C4E05_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS07525	COG0277	FAD linked oxidase domain protein
C4E05_RS07535	COG2086	electron transfer activity
C4E05_RS07540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E05_RS07545	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C4E05_RS07550	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C4E05_RS07555	COG0644	oxidoreductase
C4E05_RS07560	COG0720	synthase
C4E05_RS07585	COG1203	CRISPR-associated helicase, Cas3
C4E05_RS07600	COG1857	crispr-associated protein
C4E05_RS07615	COG1518	maintenance of DNA repeat elements
C4E05_RS07620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4E05_RS07625	COG2234	aminopeptidase activity
C4E05_RS07680	COG1388	LysM domain
C4E05_RS07680	COG4942	peptidase
C4E05_RS07685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4E05_RS07690	COG2610	gluconate transmembrane transporter activity
C4E05_RS07695	COG3622	Belongs to the hyi family
C4E05_RS07700	COG0235	Class ii aldolase
C4E05_RS07705	COG3395	kinase activity
C4E05_RS07710	COG2084	Dehydrogenase
C4E05_RS07715	COG1349	DNA-binding transcription factor activity
C4E05_RS07720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4E05_RS07735	COG3604	Transcriptional regulator
C4E05_RS07740	COG0309	Hydrogenase expression formation protein (HypE)
C4E05_RS07745	COG0409	Hydrogenase expression formation protein
C4E05_RS07750	COG0298	carbon dioxide binding
C4E05_RS07755	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4E05_RS07760	COG0375	protein maturation
C4E05_RS07775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS07780	COG0651	ATP synthesis coupled electron transport
C4E05_RS07785	COG0650	Formate hydrogenlyase subunit 4
C4E05_RS07790	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C4E05_RS07790	COG3261	NADH dehydrogenase
C4E05_RS07795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4E05_RS07800	COG3260	NADH ubiquinone oxidoreductase 20
C4E05_RS07810	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C4E05_RS07815	COG2723	6-phospho-beta-galactosidase activity
C4E05_RS07820	COG1263	PTS System
C4E05_RS07820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS07825	COG1609	Transcriptional regulator
C4E05_RS07830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS07835	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C4E05_RS07855	COG0517	IMP dehydrogenase activity
C4E05_RS07855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4E05_RS07860	COG1349	DNA-binding transcription factor activity
C4E05_RS07865	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS07875	COG3731	PTS system glucitol sorbitol-specific IIA component
C4E05_RS07880	COG3732	PTS system glucitol sorbitol-specific
C4E05_RS07885	COG3730	PTS system glucitol sorbitol-specific
C4E05_RS07890	COG2951	lytic endotransglycosylase activity
C4E05_RS07895	COG1546	Belongs to the CinA family
C4E05_RS07915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4E05_RS07945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E05_RS07950	COG1238	metal cluster binding
C4E05_RS07965	COG2814	Major facilitator Superfamily
C4E05_RS07970	COG1566	PFAM secretion protein HlyD family protein
C4E05_RS07975	COG1846	Transcriptional regulator
C4E05_RS07985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4E05_RS07990	COG2814	Major facilitator Superfamily
C4E05_RS07995	COG2113	Glycine betaine
C4E05_RS08000	COG4176	ABC-type proline glycine betaine transport system permease component
C4E05_RS08005	COG4175	Glycine betaine
C4E05_RS08010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4E05_RS08015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4E05_RS08025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4E05_RS08030	COG4575	ribosome binding
C4E05_RS08045	COG2916	Histone family protein nucleoid-structuring protein H-NS
C4E05_RS08050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4E05_RS08055	COG0640	Transcriptional regulator
C4E05_RS08060	COG0401	homolog of Blt101
C4E05_RS08065	COG1652	LysM domain
C4E05_RS08070	COG1802	Transcriptional regulator
C4E05_RS08075	COG1113	amino acid transport
C4E05_RS08080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4E05_RS08085	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS08090	COG0579	oxidoreductase
C4E05_RS08105	COG0366	Alpha amylase catalytic
C4E05_RS08130	COG3468	outer membrane autotransporter barrel domain protein
C4E05_RS08145	COG2867	negative regulation of translational initiation
C4E05_RS08155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4E05_RS08160	COG0497	DNA recombination
C4E05_RS08175	COG4536	flavin adenine dinucleotide binding
C4E05_RS08180	COG4137	Cytochrome C assembly protein
C4E05_RS08185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4E05_RS08210	COG2885	chlorophyll binding
C4E05_RS08215	COG2199	diguanylate cyclase activity
C4E05_RS08230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4E05_RS08235	COG0287	Prephenate dehydrogenase
C4E05_RS08235	COG1605	Chorismate mutase
C4E05_RS08240	COG1605	Chorismate mutase
C4E05_RS08240	COG0077	Prephenate dehydratase
C4E05_RS08250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C4E05_RS08255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4E05_RS08260	COG0564	pseudouridine synthase activity
C4E05_RS08265	COG1496	oxidoreductase activity
C4E05_RS08270	COG0542	response to heat
C4E05_RS08295	COG0477	Major facilitator Superfamily
C4E05_RS08300	COG5544	Lipoprotein
C4E05_RS08305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4E05_RS08310	COG1042	CoA-binding domain protein
C4E05_RS08310	COG0045	succinate-CoA ligase (ADP-forming) activity
C4E05_RS08310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4E05_RS08315	COG3148	PFAM DTW domain containing protein
C4E05_RS08320	COG3118	belongs to the thioredoxin family
C4E05_RS08325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4E05_RS08345	COG0583	DNA-binding transcription factor activity
C4E05_RS08350	COG0513	Belongs to the DEAD box helicase family
C4E05_RS08360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4E05_RS08370	COG1595	DNA-templated transcription, initiation
C4E05_RS08375	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C4E05_RS08380	COG3026	antisigma factor binding
C4E05_RS08385	COG3086	response to oxidative stress
C4E05_RS08395	COG0681	Belongs to the peptidase S26 family
C4E05_RS08415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4E05_RS08430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS08435	COG1737	Transcriptional regulator
C4E05_RS08440	COG0560	Phosphoserine phosphatase
C4E05_RS08455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4E05_RS08455	COG0047	phosphoribosylformylglycinamidine synthase activity
C4E05_RS08460	COG2205	protein histidine kinase activity
C4E05_RS08465	COG3170	Tfp pilus assembly protein FimV
C4E05_RS08470	COG2204	response regulator
C4E05_RS08475	COG0347	Belongs to the P(II) protein family
C4E05_RS08480	COG1017	nitric oxide dioxygenase activity
C4E05_RS08480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4E05_RS08490	COG1940	carbohydrate kinase activity
C4E05_RS08495	COG0457	Tetratricopeptide repeat
C4E05_RS08500	COG1879	ABC-type sugar transport system periplasmic component
C4E05_RS08505	COG1129	ABC transporter
C4E05_RS08510	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4E05_RS08515	COG1063	alcohol dehydrogenase
C4E05_RS08520	COG2017	converts alpha-aldose to the beta-anomer
C4E05_RS08525	COG2259	Doxx family
C4E05_RS08550	COG4638	Rieske (2fe-2S)
C4E05_RS08555	COG0583	DNA-binding transcription factor activity
C4E05_RS08560	COG2814	Major facilitator Superfamily
C4E05_RS08565	COG3711	transcriptional antiterminator
C4E05_RS08570	COG1073	alpha beta
C4E05_RS08575	COG0483	inositol monophosphate 1-phosphatase activity
C4E05_RS08595	COG0822	iron-sulfur transferase activity
C4E05_RS08615	COG0633	Ferredoxin
C4E05_RS08620	COG2975	iron-sulfur cluster assembly
C4E05_RS08635	COG2897	thiosulfate sulfurtransferase activity
C4E05_RS08640	COG2373	Large extracellular alpha-helical protein
C4E05_RS08645	COG4953	penicillin-binding protein 1C
C4E05_RS08675	COG2976	Protein conserved in bacteria
C4E05_RS08690	COG1645	bacterial-type flagellum-dependent swarming motility
C4E05_RS08700	COG0516	GMP reductase activity
C4E05_RS08700	COG0517	IMP dehydrogenase activity
C4E05_RS08715	COG3133	Outer membrane lipoprotein
C4E05_RS08725	COG2200	EAL domain
C4E05_RS08730	COG0248	Ppx GppA phosphatase
C4E05_RS08735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C4E05_RS08740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4E05_RS08755	COG2233	PERMEase
C4E05_RS08765	COG1393	Belongs to the ArsC family
C4E05_RS08770	COG4783	chaperone-mediated protein folding
C4E05_RS08775	COG0628	permease
C4E05_RS08780	COG2116	formate transmembrane transporter activity
C4E05_RS08785	COG3604	Transcriptional regulator
C4E05_RS08795	COG3260	NADH ubiquinone oxidoreductase 20
C4E05_RS08800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4E05_RS08805	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C4E05_RS08805	COG3261	NADH dehydrogenase
C4E05_RS08810	COG0651	ATP synthesis coupled electron transport
C4E05_RS08815	COG4237	Hydrogenase 4 membrane
C4E05_RS08820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4E05_RS08825	COG0650	Formate hydrogenlyase subunit 4
C4E05_RS08830	COG0651	ATP synthesis coupled electron transport
C4E05_RS08835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS08840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4E05_RS08845	COG2716	regulation of RNA biosynthetic process
C4E05_RS08855	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C4E05_RS08865	COG2321	neutral zinc metallopeptidase
C4E05_RS08870	COG1444	tRNA N-acetyltransferase activity
C4E05_RS08875	COG0400	carboxylic ester hydrolase activity
C4E05_RS08890	COG1393	Belongs to the ArsC family
C4E05_RS08900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4E05_RS08905	COG3850	Histidine kinase
C4E05_RS08910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS08910	COG0493	'glutamate synthase
C4E05_RS08920	COG5342	invasion associated locus B
C4E05_RS08925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4E05_RS08930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E05_RS08935	COG0281	malic enzyme
C4E05_RS08935	COG0280	phosphate acetyltransferase
C4E05_RS08940	COG4810	utilization protein
C4E05_RS08945	COG4917	ethanolamine utilization protein
C4E05_RS08950	COG4766	ethanolamine catabolic process
C4E05_RS08955	COG4812	Cobalamin adenosyltransferase
C4E05_RS08960	COG0280	phosphate acetyltransferase
C4E05_RS08965	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C4E05_RS08970	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C4E05_RS08975	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS08980	COG4820	ethanolamine utilization protein (EutJ)
C4E05_RS08985	COG1454	alcohol dehydrogenase
C4E05_RS08990	COG3192	ethanolamine utilization protein
C4E05_RS08995	COG4819	ethanolamine utilization protein
C4E05_RS09000	COG4303	Ethanolamine ammonia lyase large subunit
C4E05_RS09010	COG4816	utilization protein
C4E05_RS09015	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C4E05_RS09020	COG2207	Transcriptional regulator
C4E05_RS09030	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E05_RS09035	COG0456	acetyltransferase
C4E05_RS09050	COG2837	iron assimilation
C4E05_RS09055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4E05_RS09060	COG1263	PTS System
C4E05_RS09060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS09080	COG4150	thiosulfate binding
C4E05_RS09085	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C4E05_RS09090	COG4208	sulfate ABC transporter
C4E05_RS09095	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4E05_RS09100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4E05_RS09105	COG3831	ATPase activity
C4E05_RS09105	COG4884	unkown
C4E05_RS09120	COG2190	(PTS) system
C4E05_RS09125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4E05_RS09130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS09135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4E05_RS09155	COG3530	Putative quorum-sensing-regulated virulence factor
C4E05_RS09160	COG0385	Bile acid
C4E05_RS09165	COG0583	DNA-binding transcription factor activity
C4E05_RS09175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C4E05_RS09180	COG2211	Major facilitator Superfamily
C4E05_RS09190	COG0583	DNA-binding transcription factor activity
C4E05_RS09220	COG3415	Transposase
C4E05_RS09225	COG3415	Transposase
C4E05_RS09240	COG2200	EAL domain
C4E05_RS09240	COG2199	diguanylate cyclase activity
C4E05_RS09245	COG3385	transposase activity
C4E05_RS09250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C4E05_RS09275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS09280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS09285	COG0006	proline dipeptidase activity
C4E05_RS09290	COG1363	Peptidase, m42
C4E05_RS09295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS09295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4E05_RS09295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS09305	COG3279	Response regulator of the LytR AlgR family
C4E05_RS09310	COG3275	phosphorelay sensor kinase activity
C4E05_RS09315	COG0436	Aminotransferase
C4E05_RS09325	COG1560	Kdo2-lipid A biosynthetic process
C4E05_RS09350	COG0028	Belongs to the TPP enzyme family
C4E05_RS09355	COG0679	Auxin Efflux Carrier
C4E05_RS09360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4E05_RS09365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS09365	COG2198	Histidine kinase
C4E05_RS09365	COG0784	Response regulator, receiver
C4E05_RS09365	COG2205	protein histidine kinase activity
C4E05_RS09370	COG2197	response regulator
C4E05_RS09375	COG1566	PFAM secretion protein HlyD family protein
C4E05_RS09380	COG0477	Major facilitator Superfamily
C4E05_RS09420	COG2116	formate transmembrane transporter activity
C4E05_RS09425	COG2853	Lipoprotein
C4E05_RS09435	COG3547	Transposase (IS116 IS110 IS902 family)
C4E05_RS09440	COG2067	long-chain fatty acid transport protein
C4E05_RS09445	COG3691	Protein conserved in bacteria
C4E05_RS09460	COG2062	phosphohistidine phosphatase, SixA
C4E05_RS09465	COG3539	Fimbrial protein
C4E05_RS09470	COG3188	usher protein
C4E05_RS09475	COG3121	Chaperone
C4E05_RS09480	COG3539	Fimbrial protein
C4E05_RS09485	COG3539	Fimbrial protein
C4E05_RS09490	COG3539	Fimbrial protein
C4E05_RS09505	COG2890	protein-(glutamine-N5) methyltransferase activity
C4E05_RS09520	COG0730	response to heat
C4E05_RS09525	COG3101	peptidyl-lysine hydroxylation
C4E05_RS09540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4E05_RS09545	COG2814	Major facilitator Superfamily
C4E05_RS09560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4E05_RS09570	COG0586	Pfam SNARE associated Golgi protein
C4E05_RS09580	COG0285	dihydrofolate synthase activity
C4E05_RS09585	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C4E05_RS09590	COG1286	toxin biosynthetic process
C4E05_RS09595	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4E05_RS09600	COG0163	prenyltransferase activity
C4E05_RS09605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS09610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS09615	COG4215	(ABC) transporter
C4E05_RS09620	COG4160	amino acid transport
C4E05_RS09625	COG4598	ABC transporter
C4E05_RS09630	COG5464	transposase or invertase
C4E05_RS09635	COG1090	epimerase
C4E05_RS09640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4E05_RS09645	COG0625	glutathione transferase activity
C4E05_RS09650	COG0625	glutathione transferase activity
C4E05_RS09655	COG0622	Phosphoesterase
C4E05_RS09660	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C4E05_RS09665	COG1288	antiporter activity
C4E05_RS09670	COG0857	belongs to the CobB CobQ family
C4E05_RS09670	COG0280	phosphate acetyltransferase
C4E05_RS09675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4E05_RS09690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E05_RS09695	COG0471	metal ion transport
C4E05_RS09695	COG0490	domain, Protein
C4E05_RS09705	COG0436	Aminotransferase
C4E05_RS09710	COG0583	DNA-binding transcription factor activity
C4E05_RS09730	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C4E05_RS09735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C4E05_RS09740	COG1034	ATP synthesis coupled electron transport
C4E05_RS09755	COG0839	Belongs to the complex I subunit 6 family
C4E05_RS09765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4E05_RS09770	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4E05_RS09780	COG0457	Tetratricopeptide repeat
C4E05_RS09800	COG2234	aminopeptidase activity
C4E05_RS09805	COG2304	oxidoreductase activity
C4E05_RS09810	COG5160	protein modification by small protein removal
C4E05_RS09820	COG2153	protein acetylation
C4E05_RS09825	COG4575	ribosome binding
C4E05_RS09830	COG1169	isochorismate synthase
C4E05_RS09845	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C4E05_RS09855	COG0318	PFAM AMP-dependent synthetase and ligase
C4E05_RS09930	COG2271	Major facilitator Superfamily
C4E05_RS09945	COG5464	transposase or invertase
C4E05_RS09950	COG0247	lactate metabolic process
C4E05_RS09960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C4E05_RS09965	COG2271	Major facilitator Superfamily
C4E05_RS09970	COG0584	glycerophosphoryl diester phosphodiesterase
C4E05_RS09980	COG3642	lipopolysaccharide core region biosynthetic process
C4E05_RS09985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4E05_RS09990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4E05_RS09995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4E05_RS10000	COG3468	outer membrane autotransporter barrel domain protein
C4E05_RS10010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C4E05_RS10015	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
C4E05_RS10020	COG3234	Protein of unknown function (DUF1175)
C4E05_RS10025	COG2373	Large extracellular alpha-helical protein
C4E05_RS10030	COG5445	Predicted secreted protein (DUF2300)
C4E05_RS10035	COG4676	Protein conserved in bacteria
C4E05_RS10040	COG0183	Belongs to the thiolase family
C4E05_RS10045	COG2031	fatty acid transporter
C4E05_RS10050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4E05_RS10055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4E05_RS10060	COG2204	response regulator
C4E05_RS10065	COG3852	Histidine kinase
C4E05_RS10070	COG2205	protein histidine kinase activity
C4E05_RS10070	COG0784	Response regulator, receiver
C4E05_RS10075	COG2197	response regulator
C4E05_RS10080	COG2198	Histidine kinase
C4E05_RS10080	COG0642	Histidine kinase
C4E05_RS10085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4E05_RS10090	COG1477	protein flavinylation
C4E05_RS10095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4E05_RS10095	COG2169	Transcriptional regulator
C4E05_RS10100	COG3145	DNA-N1-methyladenine dioxygenase activity
C4E05_RS10105	COG4615	Cyclic peptide transporter
C4E05_RS10120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS10120	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4E05_RS10125	COG3062	negative regulation of establishment of protein localization
C4E05_RS10135	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS10140	COG0348	domain, Protein
C4E05_RS10145	COG3043	anaerobic respiration
C4E05_RS10150	COG3005	denitrification pathway
C4E05_RS10155	COG4133	protoheme IX ABC transporter activity
C4E05_RS10160	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4E05_RS10165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4E05_RS10170	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4E05_RS10180	COG1138	Cytochrome C-type biogenesis protein
C4E05_RS10185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4E05_RS10190	COG4235	cytochrome complex assembly
C4E05_RS10190	COG3088	subunit of a heme lyase
C4E05_RS10195	COG2197	response regulator
C4E05_RS10200	COG3468	outer membrane autotransporter barrel domain protein
C4E05_RS10210	COG3083	sulfuric ester hydrolase activity
C4E05_RS10230	COG1061	Type III restriction enzyme res subunit
C4E05_RS10235	COG1187	pseudouridine synthase activity
C4E05_RS10240	COG2814	Major facilitator Superfamily
C4E05_RS10250	COG4172	Belongs to the ABC transporter superfamily
C4E05_RS10255	COG4239	(ABC) transporter, permease
C4E05_RS10260	COG4174	ABC transporter (Permease)
C4E05_RS10265	COG4166	transmembrane transport
C4E05_RS10270	COG2200	EAL domain
C4E05_RS10275	COG0791	NLP P60 protein
C4E05_RS10280	COG0671	phosphoesterase, PA-phosphatase related
C4E05_RS10285	COG0523	cobalamin synthesis protein
C4E05_RS10290	COG0246	Mannitol dehydrogenase
C4E05_RS10305	COG2814	Major facilitator Superfamily
C4E05_RS10310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS10310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS10315	COG1105	Belongs to the carbohydrate kinase PfkB family
C4E05_RS10320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS10320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS10320	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4E05_RS10325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS10330	COG2313	pseudouridylate synthase activity
C4E05_RS10335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C4E05_RS10340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4E05_RS10350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C4E05_RS10355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS10355	COG1522	sequence-specific DNA binding
C4E05_RS10365	COG2855	membrane
C4E05_RS10370	COG0583	DNA-binding transcription factor activity
C4E05_RS10375	COG0833	amino acid
C4E05_RS10395	COG2311	Membrane
C4E05_RS10400	COG1609	Transcriptional regulator
C4E05_RS10405	COG1879	ABC-type sugar transport system periplasmic component
C4E05_RS10410	COG1129	ABC transporter
C4E05_RS10415	COG4211	Belongs to the binding-protein-dependent transport system permease family
C4E05_RS10420	COG0167	dihydroorotate dehydrogenase activity
C4E05_RS10420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4E05_RS10425	COG0493	'glutamate synthase
C4E05_RS10435	COG2949	membrane
C4E05_RS10445	COG1346	cytolysis
C4E05_RS10455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4E05_RS10470	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS10475	COG0586	Pfam SNARE associated Golgi protein
C4E05_RS10485	COG1686	Belongs to the peptidase S11 family
C4E05_RS10490	COG0277	FAD linked oxidase domain protein
C4E05_RS10495	COG1472	Belongs to the glycosyl hydrolase 3 family
C4E05_RS10500	COG1732	Glycine betaine
C4E05_RS10505	COG1174	glycine betaine transport
C4E05_RS10510	COG1125	glycine betaine transport
C4E05_RS10515	COG1174	glycine betaine transport
C4E05_RS10525	COG0789	Transcriptional regulator
C4E05_RS10530	COG3275	phosphorelay sensor kinase activity
C4E05_RS10535	COG3279	Response regulator of the LytR AlgR family
C4E05_RS10540	COG4807	Protein conserved in bacteria
C4E05_RS10545	COG4808	Protein conserved in bacteria
C4E05_RS10550	COG4715	Zinc finger, swim domain protein
C4E05_RS10555	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C4E05_RS10575	COG3831	ATPase activity
C4E05_RS10580	COG3831	ATPase activity
C4E05_RS10585	COG3831	ATPase activity
C4E05_RS10595	COG0489	protein tyrosine kinase activity
C4E05_RS10605	COG3539	Fimbrial protein
C4E05_RS10610	COG3121	Chaperone
C4E05_RS10615	COG3188	usher protein
C4E05_RS10620	COG3539	Fimbrial protein
C4E05_RS10625	COG5455	response to cobalt ion
C4E05_RS10645	COG0351	phosphomethylpyrimidine kinase
C4E05_RS10650	COG3757	hydrolase, family 25
C4E05_RS10655	COG2188	Transcriptional regulator
C4E05_RS10660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS10665	COG1397	ADP-ribosylglycohydrolase
C4E05_RS10670	COG2211	Major facilitator Superfamily
C4E05_RS10675	COG1830	Aldolase
C4E05_RS10690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS10695	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E05_RS10700	COG3775	system Galactitol-specific IIC component
C4E05_RS10705	COG1063	alcohol dehydrogenase
C4E05_RS10725	COG0826	peptidase U32
C4E05_RS10735	COG0745	RESPONSE REGULATOR receiver
C4E05_RS10740	COG2205	protein histidine kinase activity
C4E05_RS10780	COG4245	von Willebrand factor, type A
C4E05_RS10790	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C4E05_RS10795	COG0443	Heat shock 70 kDa protein
C4E05_RS10800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C4E05_RS10810	COG3547	Transposase (IS116 IS110 IS902 family)
C4E05_RS10820	COG0572	uridine kinase
C4E05_RS10830	COG2982	Protein involved in outer membrane biogenesis
C4E05_RS10835	COG1253	flavin adenine dinucleotide binding
C4E05_RS10855	COG2826	transposase and inactivated derivatives, IS30 family
C4E05_RS10895	COG5039	Polysaccharide pyruvyl transferase
C4E05_RS10975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4E05_RS10975	COG0140	phosphoribosyl-ATP diphosphatase activity
C4E05_RS10990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4E05_RS10995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4E05_RS10995	COG0131	Imidazoleglycerol-phosphate dehydratase
C4E05_RS11020	COG2161	toxin-antitoxin pair type II binding
C4E05_RS11025	COG4115	mRNA cleavage
C4E05_RS11030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4E05_RS11035	COG0583	DNA-binding transcription factor activity
C4E05_RS11045	COG0531	amino acid
C4E05_RS11050	COG2391	methyltransferase activity
C4E05_RS11055	COG0425	Belongs to the sulfur carrier protein TusA family
C4E05_RS11060	COG2925	Exonuclease
C4E05_RS11065	COG1686	Belongs to the peptidase S11 family
C4E05_RS11080	COG1289	transmembrane transporter activity
C4E05_RS11110	COG3436	PFAM IS66 Orf2 family protein
C4E05_RS11115	COG4372	Transposase
C4E05_RS11145	COG2003	Belongs to the UPF0758 family
C4E05_RS11175	COG3468	outer membrane autotransporter barrel domain protein
C4E05_RS11180	COG4584	PFAM Integrase catalytic
C4E05_RS11185	COG1484	DNA-dependent DNA replication
C4E05_RS11280	COG2826	transposase and inactivated derivatives, IS30 family
C4E05_RS11300	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C4E05_RS11315	COG1376	ErfK ybiS ycfS ynhG family protein
C4E05_RS11325	COG0583	DNA-binding transcription factor activity
C4E05_RS11330	COG0583	DNA-binding transcription factor activity
C4E05_RS11355	COG0217	transcriptional regulatory protein
C4E05_RS11360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4E05_RS11365	COG0477	Major facilitator Superfamily
C4E05_RS11375	COG1388	LysM domain
C4E05_RS11375	COG1470	cell adhesion involved in biofilm formation
C4E05_RS11395	COG3038	cytochrome b561
C4E05_RS11400	COG3443	Belongs to the bacterial solute-binding protein 9 family
C4E05_RS11415	COG2351	hydroxyisourate hydrolase activity
C4E05_RS11420	COG0745	RESPONSE REGULATOR receiver
C4E05_RS11425	COG2205	protein histidine kinase activity
C4E05_RS11440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4E05_RS11450	COG1418	mRNA catabolic process
C4E05_RS11455	COG0270	DNA (cytosine-5-)-methyltransferase activity
C4E05_RS11460	COG3727	T/G mismatch-specific endonuclease activity
C4E05_RS11465	COG0697	spore germination
C4E05_RS11470	COG2354	Protein conserved in bacteria
C4E05_RS11475	COG5475	Uncharacterized small protein (DUF2158)
C4E05_RS11500	COG2197	response regulator
C4E05_RS11505	COG1684	flagellar biosynthetic protein fliR
C4E05_RS11510	COG1987	bacterial-type flagellum assembly
C4E05_RS11515	COG1338	Plays a role in the flagellum-specific transport system
C4E05_RS11520	COG3190	flagellar
C4E05_RS11525	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4E05_RS11530	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4E05_RS11535	COG1580	Controls the rotational direction of flagella during chemotaxis
C4E05_RS11540	COG3144	bacterial-type flagellum assembly
C4E05_RS11545	COG2882	bacterial-type flagellum organization
C4E05_RS11555	COG1317	bacterial-type flagellum organization
C4E05_RS11560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C4E05_RS11565	COG1766	The M ring may be actively involved in energy transduction
C4E05_RS11590	COG2135	peptidase activity
C4E05_RS11595	COG0425	Belongs to the sulfur carrier protein TusA family
C4E05_RS11600	COG2391	methyltransferase activity
C4E05_RS11610	COG0366	Alpha amylase catalytic
C4E05_RS11620	COG1516	flagellar protein fliS
C4E05_RS11625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C4E05_RS11635	COG1191	sigma factor activity
C4E05_RS11645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS11655	COG0765	amino acid transport
C4E05_RS11660	COG1126	abc transporter atp-binding protein
C4E05_RS11665	COG2197	response regulator
C4E05_RS11685	COG2197	response regulator
C4E05_RS11715	COG3012	SEC-C Motif Domain Protein
C4E05_RS11715	COG3318	Belongs to the UPF0149 family
C4E05_RS11720	COG0814	amino acid
C4E05_RS11730	COG1528	Iron-storage protein
C4E05_RS11750	COG1528	Iron-storage protein
C4E05_RS11755	COG1879	ABC-type sugar transport system periplasmic component
C4E05_RS11760	COG1129	ABC transporter
C4E05_RS11765	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4E05_RS11770	COG1877	trehalose-phosphatase activity
C4E05_RS11780	COG0589	response to stress
C4E05_RS11795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C4E05_RS11800	COG1360	Flagellar Motor Protein
C4E05_RS11805	COG0643	Histidine kinase
C4E05_RS11805	COG2198	Histidine kinase
C4E05_RS11810	COG0835	chemotaxis
C4E05_RS11815	COG0840	transmembrane signaling receptor activity
C4E05_RS11820	COG0840	transmembrane signaling receptor activity
C4E05_RS11825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C4E05_RS11830	COG2201	protein-glutamate methylesterase activity
C4E05_RS11835	COG0745	RESPONSE REGULATOR receiver
C4E05_RS11840	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C4E05_RS11845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4E05_RS11850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C4E05_RS11860	COG3755	Protein conserved in bacteria
C4E05_RS11870	COG3102	Protein conserved in bacteria
C4E05_RS11880	COG3005	denitrification pathway
C4E05_RS11885	COG0243	molybdopterin cofactor binding
C4E05_RS11900	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C4E05_RS11905	COG1801	Protein of unknown function DUF72
C4E05_RS11910	COG1335	isochorismatase
C4E05_RS11920	COG0494	nUDIX hydrolase
C4E05_RS11925	COG0217	transcriptional regulatory protein
C4E05_RS11955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4E05_RS11965	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C4E05_RS11970	COG0739	heme binding
C4E05_RS11975	COG1560	Kdo2-lipid A biosynthetic process
C4E05_RS11980	COG0469	pyruvate kinase activity
C4E05_RS11985	COG1737	Transcriptional regulator
C4E05_RS11990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4E05_RS11995	COG0129	dihydroxy-acid dehydratase activity
C4E05_RS12000	COG0800	Aldolase
C4E05_RS12010	COG3141	response to X-ray
C4E05_RS12020	COG2979	Protein of unknown function (DUF533)
C4E05_RS12025	COG1770	oligopeptidase
C4E05_RS12030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4E05_RS12035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4E05_RS12045	COG2372	response to copper ion
C4E05_RS12050	COG1276	copper resistance
C4E05_RS12060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4E05_RS12080	COG3008	intermembrane lipid transfer
C4E05_RS12085	COG2995	paraquat-inducible protein a
C4E05_RS12090	COG1956	GAF domain-containing protein
C4E05_RS12100	COG0793	Belongs to the peptidase S41A family
C4E05_RS12110	COG2814	Major facilitator Superfamily
C4E05_RS12115	COG1414	Transcriptional regulator
C4E05_RS12145	COG2226	methyltransferase
C4E05_RS12160	COG3716	PTS system mannose fructose sorbose family IID component
C4E05_RS12165	COG3715	PTS system
C4E05_RS12170	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS12170	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS12175	COG1253	flavin adenine dinucleotide binding
C4E05_RS12180	COG2200	EAL domain
C4E05_RS12185	COG1760	l-serine dehydratase
C4E05_RS12195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4E05_RS12210	COG0251	oxidation-reduction process
C4E05_RS12215	COG1199	ATP-dependent helicase activity
C4E05_RS12220	COG1214	PFAM Peptidase M22, glycoprotease
C4E05_RS12225	COG3065	identical protein binding
C4E05_RS12230	COG0318	PFAM AMP-dependent synthetase and ligase
C4E05_RS12235	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C4E05_RS12240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4E05_RS12245	COG4638	Rieske (2fe-2S)
C4E05_RS12250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4E05_RS12255	COG0473	3-isopropylmalate dehydrogenase activity
C4E05_RS12260	COG0583	DNA-binding transcription factor activity
C4E05_RS12270	COG3615	Tellurite resistance protein tehB
C4E05_RS12280	COG2261	transglycosylase associated protein
C4E05_RS12295	COG2199	diguanylate cyclase activity
C4E05_RS12295	COG2203	Gaf domain
C4E05_RS12300	COG3042	response to heat
C4E05_RS12305	COG3189	MarR family transcriptional regulator
C4E05_RS12310	COG2807	transmembrane transport
C4E05_RS12315	COG2207	Transcriptional regulator
C4E05_RS12330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4E05_RS12335	COG2199	diguanylate cyclase activity
C4E05_RS12340	COG2199	diguanylate cyclase activity
C4E05_RS12350	COG2766	serine protein kinase
C4E05_RS12355	COG3713	MltA-interacting MipA family protein
C4E05_RS12360	COG0656	L-ascorbic acid biosynthetic process
C4E05_RS12365	COG0676	glucose-6-phosphate 1-epimerase activity
C4E05_RS12370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4E05_RS12380	COG3139	Protein of unknown function (DUF1315)
C4E05_RS12385	COG1063	alcohol dehydrogenase
C4E05_RS12390	COG2271	Major facilitator Superfamily
C4E05_RS12395	COG1063	alcohol dehydrogenase
C4E05_RS12400	COG0191	fructose-bisphosphate aldolase activity
C4E05_RS12405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS12410	COG0667	Aldo Keto reductase
C4E05_RS12415	COG1349	DNA-binding transcription factor activity
C4E05_RS12420	COG2814	Major facilitator Superfamily
C4E05_RS12425	COG1335	isochorismatase
C4E05_RS12430	COG0252	asparaginase activity
C4E05_RS12435	COG0616	signal peptide processing
C4E05_RS12440	COG0778	Nitroreductase
C4E05_RS12450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E05_RS12460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4E05_RS12470	COG0494	nUDIX hydrolase
C4E05_RS12475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4E05_RS12480	COG2897	thiosulfate sulfurtransferase activity
C4E05_RS12485	COG4136	ATPase activity
C4E05_RS12490	COG4135	transport system, permease component
C4E05_RS12495	COG4134	Bacterial extracellular solute-binding protein
C4E05_RS12500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4E05_RS12505	COG0398	Pfam SNARE associated Golgi protein
C4E05_RS12515	COG0398	Pfam SNARE associated Golgi protein
C4E05_RS12520	COG0708	Exodeoxyribonuclease III
C4E05_RS12550	COG3678	ATP-independent chaperone mediated protein folding
C4E05_RS12560	COG0322	excinuclease ABC activity
C4E05_RS12570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4E05_RS12575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E05_RS12580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C4E05_RS12585	COG1447	Phosphotransferase system cellobiose-specific component IIA
C4E05_RS12590	COG2169	Transcriptional regulator
C4E05_RS12590	COG1917	Cupin 2, conserved barrel domain protein
C4E05_RS12595	COG1486	melibiose metabolic process
C4E05_RS12605	COG0753	catalase activity
C4E05_RS12620	COG1823	symporter activity
C4E05_RS12625	COG1988	membrane-bound metal-dependent
C4E05_RS12630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E05_RS12640	COG3001	Fructosamine kinase
C4E05_RS12650	COG1105	Belongs to the carbohydrate kinase PfkB family
C4E05_RS12655	COG3137	Salt-induced outer membrane protein
C4E05_RS12700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4E05_RS12700	COG0072	phenylalanine-tRNA ligase activity
C4E05_RS12715	COG0386	Belongs to the glutathione peroxidase family
C4E05_RS12725	COG0791	NLP P60 protein
C4E05_RS12730	COG2200	EAL domain
C4E05_RS12740	COG4256	Hemin uptake protein
C4E05_RS12745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4E05_RS12755	COG0574	Belongs to the PEP-utilizing enzyme family
C4E05_RS12755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4E05_RS12760	COG0318	PFAM AMP-dependent synthetase and ligase
C4E05_RS12765	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C4E05_RS12770	COG0644	oxidoreductase
C4E05_RS12775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C4E05_RS12780	COG2086	electron transfer activity
C4E05_RS12785	COG1917	Cupin 2, conserved barrel domain protein
C4E05_RS12785	COG2207	Transcriptional regulator
C4E05_RS12790	COG1960	acyl-CoA dehydrogenase activity
C4E05_RS12795	COG4670	ketone body catabolic process
C4E05_RS12810	COG2271	Major facilitator Superfamily
C4E05_RS12815	COG0738	Major facilitator superfamily
C4E05_RS12830	COG0628	permease
C4E05_RS12835	COG0247	lactate metabolic process
C4E05_RS12835	COG0277	FAD linked oxidase domain protein
C4E05_RS12840	COG2050	protein possibly involved in aromatic compounds catabolism
C4E05_RS12850	COG0316	Belongs to the HesB IscA family
C4E05_RS12855	COG0719	Fe-S assembly protein
C4E05_RS12860	COG0396	ATPase activity
C4E05_RS12865	COG0719	Fe-S assembly protein
C4E05_RS12880	COG1376	ErfK ybiS ycfS ynhG family protein
C4E05_RS12885	COG4238	major outer membrane lipoprotein
C4E05_RS12890	COG0469	pyruvate kinase activity
C4E05_RS12900	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS12905	COG2414	aldehyde ferredoxin oxidoreductase
C4E05_RS12915	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS12920	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C4E05_RS12930	COG4529	Protein conserved in bacteria
C4E05_RS12950	COG3468	outer membrane autotransporter barrel domain protein
C4E05_RS12960	COG0307	riboflavin synthase, alpha
C4E05_RS12965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4E05_RS12970	COG2814	Major facilitator Superfamily
C4E05_RS12975	COG0583	DNA-binding transcription factor activity
C4E05_RS12990	COG2814	Major facilitator Superfamily
C4E05_RS12995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4E05_RS13000	COG0791	NLP P60 protein
C4E05_RS13005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4E05_RS13010	COG1201	RNA secondary structure unwinding
C4E05_RS13015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4E05_RS13020	COG0346	lactoylglutathione lyase activity
C4E05_RS13025	COG1902	pentaerythritol trinitrate reductase activity
C4E05_RS13030	COG1309	transcriptional regulator
C4E05_RS13035	COG3313	Fe-S protein
C4E05_RS13040	COG4989	oxidoreductase activity
C4E05_RS13045	COG2032	superoxide dismutase activity
C4E05_RS13050	COG1289	transmembrane transporter activity
C4E05_RS13055	COG1566	PFAM secretion protein HlyD family protein
C4E05_RS13070	COG3133	Outer membrane lipoprotein
C4E05_RS13080	COG3895	Periplasmic Protein
C4E05_RS13095	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C4E05_RS13100	COG0625	glutathione transferase activity
C4E05_RS13105	COG3104	oligopeptide transport
C4E05_RS13110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4E05_RS13120	COG4659	FMN binding
C4E05_RS13160	COG0673	inositol 2-dehydrogenase activity
C4E05_RS13170	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4E05_RS13175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS13175	COG1263	PTS System
C4E05_RS13180	COG1609	Transcriptional regulator
C4E05_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS13190	COG1309	transcriptional regulator
C4E05_RS13195	COG3250	beta-galactosidase activity
C4E05_RS13210	COG5339	Protein conserved in bacteria
C4E05_RS13215	COG1482	cell wall glycoprotein biosynthetic process
C4E05_RS13220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4E05_RS13220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C4E05_RS13225	COG0114	fumarate hydratase activity
C4E05_RS13235	COG2205	protein histidine kinase activity
C4E05_RS13240	COG0745	RESPONSE REGULATOR receiver
C4E05_RS13245	COG3136	membrane protein required for alginate biosynthesis
C4E05_RS13255	COG0531	amino acid
C4E05_RS13265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4E05_RS13270	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C4E05_RS13275	COG0628	permease
C4E05_RS13295	COG3591	Belongs to the peptidase S1B family
C4E05_RS13310	COG2814	Major facilitator Superfamily
C4E05_RS13315	COG0583	DNA-binding transcription factor activity
C4E05_RS13320	COG1940	carbohydrate kinase activity
C4E05_RS13325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4E05_RS13335	COG3381	protein complex oligomerization
C4E05_RS13340	COG3302	dmso reductase anchor subunit
C4E05_RS13345	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS13350	COG0243	molybdopterin cofactor binding
C4E05_RS13355	COG0243	molybdopterin cofactor binding
C4E05_RS13370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4E05_RS13385	COG4948	Mandelate Racemase Muconate Lactonizing
C4E05_RS13390	COG1063	alcohol dehydrogenase
C4E05_RS13395	COG0477	Major facilitator Superfamily
C4E05_RS13400	COG0246	Mannitol dehydrogenase
C4E05_RS13410	COG1802	Transcriptional regulator
C4E05_RS13415	COG4221	oxidoreductase activity
C4E05_RS13420	COG0339	signal peptide processing
C4E05_RS13425	COG1546	Belongs to the CinA family
C4E05_RS13430	COG3111	PFAM Bacterial OB fold (BOF) protein
C4E05_RS13435	COG3706	GGDEF domain
C4E05_RS13445	COG2814	Major facilitator Superfamily
C4E05_RS13450	COG0697	spore germination
C4E05_RS13460	COG4977	sequence-specific DNA binding
C4E05_RS13465	COG1846	Transcriptional regulator
C4E05_RS13485	COG0583	DNA-binding transcription factor activity
C4E05_RS13490	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS13495	COG2066	Belongs to the glutaminase family
C4E05_RS13505	COG2199	diguanylate cyclase activity
C4E05_RS13515	COG3781	membrane
C4E05_RS13565	COG3210	domain, Protein
C4E05_RS13565	COG2911	Protein conserved in bacteria
C4E05_RS13570	COG1396	sequence-specific DNA binding
C4E05_RS13575	COG3550	peptidyl-serine autophosphorylation
C4E05_RS13590	COG3539	Fimbrial protein
C4E05_RS13595	COG3539	Fimbrial protein
C4E05_RS13600	COG3539	Fimbrial protein
C4E05_RS13605	COG0243	molybdopterin cofactor binding
C4E05_RS13615	COG2207	Transcriptional regulator
C4E05_RS13620	COG3119	arylsulfatase activity
C4E05_RS13625	COG0641	radical SAM
C4E05_RS13635	COG4178	(ABC) transporter
C4E05_RS13640	COG4771	TonB-dependent receptor
C4E05_RS13645	COG0612	Peptidase, M16
C4E05_RS13650	COG0076	glutamate decarboxylase activity
C4E05_RS13655	COG0531	amino acid
C4E05_RS13660	COG1649	PFAM Uncharacterised BCR, COG1649
C4E05_RS13665	COG3706	GGDEF domain
C4E05_RS13670	COG2199	diguanylate cyclase activity
C4E05_RS13670	COG2202	Pas domain
C4E05_RS13670	COG2200	EAL domain
C4E05_RS13675	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C4E05_RS13680	COG0747	negative chemotaxis
C4E05_RS13685	COG0601	transmembrane transport
C4E05_RS13690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E05_RS13695	COG0444	Belongs to the ABC transporter superfamily
C4E05_RS13700	COG4608	Belongs to the ABC transporter superfamily
C4E05_RS13705	COG1764	response to oxidative stress
C4E05_RS13725	COG1064	alcohol dehydrogenase
C4E05_RS13730	COG3093	addiction module antidote protein HigA
C4E05_RS13735	COG2864	formate dehydrogenase
C4E05_RS13740	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS13750	COG0697	spore germination
C4E05_RS13755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4E05_RS13765	COG4886	Leucine-rich repeat (LRR) protein
C4E05_RS13770	COG2223	nitrite transmembrane transporter activity
C4E05_RS13780	COG1140	nitrate reductase beta subunit
C4E05_RS13785	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C4E05_RS13790	COG2181	nitrate reductase activity
C4E05_RS13795	COG0384	phenazine biosynthesis protein PhzF
C4E05_RS13800	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C4E05_RS13805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4E05_RS13815	COG5433	transposase activity
C4E05_RS13850	COG0625	glutathione transferase activity
C4E05_RS13855	COG1113	amino acid transport
C4E05_RS13860	COG3391	amine dehydrogenase activity
C4E05_RS13865	COG4772	TonB-dependent receptor
C4E05_RS13870	COG1802	Transcriptional regulator
C4E05_RS13875	COG2130	NADP-dependent
C4E05_RS13880	COG1247	-acetyltransferase
C4E05_RS13885	COG3238	Protein conserved in bacteria
C4E05_RS13910	COG1177	transmembrane transport
C4E05_RS13915	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4E05_RS13920	COG3842	ATPase activity
C4E05_RS13925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4E05_RS13930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4E05_RS13935	COG1598	PFAM Uncharacterised protein family UPF0150
C4E05_RS13940	COG1724	mRNA binding
C4E05_RS13950	COG0826	peptidase U32
C4E05_RS13955	COG1396	sequence-specific DNA binding
C4E05_RS13960	COG3135	benzoate transporter
C4E05_RS13965	COG0675	Transposase, IS605 OrfB family
C4E05_RS13980	COG0500	methyltransferase
C4E05_RS13985	COG1275	C4-dicarboxylate transporter malic acid transport protein
C4E05_RS13990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4E05_RS13995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4E05_RS14000	COG2841	Protein conserved in bacteria
C4E05_RS14010	COG5383	Protein conserved in bacteria
C4E05_RS14015	COG0583	DNA-binding transcription factor activity
C4E05_RS14020	COG0840	transmembrane signaling receptor activity
C4E05_RS14035	COG3038	cytochrome b561
C4E05_RS14045	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS14050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C4E05_RS14055	COG1643	Atp-dependent helicase
C4E05_RS14065	COG2453	phosphatase
C4E05_RS14065	COG0671	phosphoesterase, PA-phosphatase related
C4E05_RS14070	COG2267	carboxylic ester hydrolase activity
C4E05_RS14075	COG4589	Belongs to the CDS family
C4E05_RS14080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4E05_RS14090	COG0667	Aldo Keto reductase
C4E05_RS14115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4E05_RS14120	COG3327	negative regulation of DNA-templated transcription, initiation
C4E05_RS14125	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C4E05_RS14130	COG0183	Belongs to the thiolase family
C4E05_RS14135	COG2050	protein possibly involved in aromatic compounds catabolism
C4E05_RS14140	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4E05_RS14145	COG1024	Enoyl-CoA hydratase
C4E05_RS14150	COG1024	Enoyl-CoA hydratase
C4E05_RS14155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4E05_RS14160	COG2151	metal-sulfur cluster biosynthetic enzyme
C4E05_RS14165	COG3396	Phenylacetate-CoA oxygenase
C4E05_RS14170	COG3460	Phenylacetate-CoA oxygenase
C4E05_RS14175	COG3396	Phenylacetate-CoA oxygenase
C4E05_RS14180	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS14180	COG2030	dehydratase
C4E05_RS14185	COG3733	amine oxidase
C4E05_RS14190	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS14195	COG2207	Transcriptional regulator
C4E05_RS14200	COG3784	Protein of unknown function (DUF1318)
C4E05_RS14210	COG2911	Protein conserved in bacteria
C4E05_RS14215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C4E05_RS14220	COG3187	Heat shock protein
C4E05_RS14225	COG3042	response to heat
C4E05_RS14230	COG0674	pyruvate-flavodoxin oxidoreductase activity
C4E05_RS14230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C4E05_RS14230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4E05_RS14230	COG1013	pyruvate-flavodoxin oxidoreductase activity
C4E05_RS14235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4E05_RS14240	COG0589	response to stress
C4E05_RS14250	COG0513	Belongs to the DEAD box helicase family
C4E05_RS14260	COG3706	GGDEF domain
C4E05_RS14265	COG2840	Smr protein MutS2
C4E05_RS14270	COG0583	DNA-binding transcription factor activity
C4E05_RS14275	COG1473	amidohydrolase
C4E05_RS14280	COG1473	amidohydrolase
C4E05_RS14285	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C4E05_RS14290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4E05_RS14295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4E05_RS14300	COG0589	response to stress
C4E05_RS14305	COG3182	Iron-regulated membrane protein
C4E05_RS14310	COG0668	transmembrane transport
C4E05_RS14315	COG4166	transmembrane transport
C4E05_RS14320	COG0583	DNA-binding transcription factor activity
C4E05_RS14325	COG1073	alpha beta
C4E05_RS14340	COG2866	Carboxypeptidase
C4E05_RS14345	COG4948	Mandelate Racemase Muconate Lactonizing
C4E05_RS14350	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C4E05_RS14355	COG3283	Transcriptional regulator of aromatic amino acids metabolism
C4E05_RS14365	COG3106	COG3106 Predicted ATPase
C4E05_RS14370	COG1609	Transcriptional regulator
C4E05_RS14380	COG3842	ATPase activity
C4E05_RS14385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E05_RS14390	COG1554	hydrolase, family 65, central catalytic
C4E05_RS14395	COG0673	inositol 2-dehydrogenase activity
C4E05_RS14400	COG1082	Xylose isomerase domain protein TIM barrel
C4E05_RS14405	COG1063	alcohol dehydrogenase
C4E05_RS14410	COG0395	ABC-type sugar transport system, permease component
C4E05_RS14415	COG1175	transmembrane transport
C4E05_RS14425	COG0366	Alpha amylase catalytic
C4E05_RS14430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4E05_RS14440	COG1983	PspC domain protein
C4E05_RS14450	COG1842	Phage shock protein A
C4E05_RS14455	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C4E05_RS14460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4E05_RS14465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4E05_RS14470	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS14475	COG1917	Cupin 2, conserved barrel domain protein
C4E05_RS14475	COG1396	sequence-specific DNA binding
C4E05_RS14480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C4E05_RS14485	COG0174	glutamine synthetase
C4E05_RS14495	COG0531	amino acid
C4E05_RS14505	COG4166	transmembrane transport
C4E05_RS14510	COG4168	peptide transport system, permease
C4E05_RS14515	COG4171	peptide transport system, permease
C4E05_RS14520	COG4172	Belongs to the ABC transporter superfamily
C4E05_RS14525	COG4172	Belongs to the ABC transporter superfamily
C4E05_RS14530	COG2852	Protein conserved in bacteria
C4E05_RS14535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C4E05_RS14540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4E05_RS14540	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4E05_RS14555	COG5001	Diguanylate cyclase
C4E05_RS14565	COG1349	DNA-binding transcription factor activity
C4E05_RS14575	COG0023	Translation Initiation Factor
C4E05_RS14585	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C4E05_RS14590	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C4E05_RS14595	COG0671	phosphoesterase, PA-phosphatase related
C4E05_RS14605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4E05_RS14630	COG0583	DNA-binding transcription factor activity
C4E05_RS14635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4E05_RS14645	COG0616	signal peptide processing
C4E05_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS14655	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C4E05_RS14660	COG1187	pseudouridine synthase activity
C4E05_RS14665	COG4907	membrane protein (DUF2207)
C4E05_RS14670	COG0009	L-threonylcarbamoyladenylate synthase
C4E05_RS14675	COG0613	PHP domain protein
C4E05_RS14685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4E05_RS14690	COG0512	Glutamine amidotransferase of anthranilate synthase
C4E05_RS14690	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4E05_RS14695	COG0135	phosphoribosylanthranilate isomerase activity
C4E05_RS14695	COG0134	indole-3-glycerol-phosphate synthase activity
C4E05_RS14710	COG3039	Transposase
C4E05_RS14715	COG3729	General stress protein
C4E05_RS14720	COG3685	Protein conserved in bacteria
C4E05_RS14725	COG3685	Protein conserved in bacteria
C4E05_RS14730	COG3047	cAMP biosynthetic process
C4E05_RS14750	COG1607	acyl-coa hydrolase
C4E05_RS14755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C4E05_RS14760	COG2350	Protein conserved in bacteria
C4E05_RS14765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4E05_RS14785	COG4608	Belongs to the ABC transporter superfamily
C4E05_RS14790	COG0444	Belongs to the ABC transporter superfamily
C4E05_RS14795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E05_RS14800	COG0601	transmembrane transport
C4E05_RS14805	COG4166	transmembrane transport
C4E05_RS14810	COG2095	MarC family integral membrane protein
C4E05_RS14815	COG1012	belongs to the aldehyde dehydrogenase family
C4E05_RS14815	COG1454	alcohol dehydrogenase
C4E05_RS14825	COG1435	thymidine kinase activity
C4E05_RS14835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4E05_RS14840	COG0745	RESPONSE REGULATOR receiver
C4E05_RS14845	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4E05_RS14855	COG0788	formyltetrahydrofolate deformylase activity
C4E05_RS14885	COG2181	nitrate reductase activity
C4E05_RS14890	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C4E05_RS14895	COG1140	nitrate reductase beta subunit
C4E05_RS14900	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C4E05_RS14905	COG2223	nitrite transmembrane transporter activity
C4E05_RS14910	COG3850	Histidine kinase
C4E05_RS14915	COG2197	response regulator
C4E05_RS14920	COG4932	domain protein
C4E05_RS14925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C4E05_RS14930	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C4E05_RS14935	COG4572	Cation transport regulator
C4E05_RS14940	COG0387	Pfam Sodium calcium exchanger
C4E05_RS14980	COG2912	Transglutaminase-like superfamily
C4E05_RS14985	COG3094	Invasion gene expression up-regulator, SirB
C4E05_RS14990	COG2890	protein-(glutamine-N5) methyltransferase activity
C4E05_RS15015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4E05_RS15020	COG0659	secondary active sulfate transmembrane transporter activity
C4E05_RS15035	COG0012	GTP binding
C4E05_RS15040	COG3468	outer membrane autotransporter barrel domain protein
C4E05_RS15045	COG3284	Transcriptional regulator
C4E05_RS15050	COG2376	Dihydroxyacetone kinase
C4E05_RS15055	COG1461	Dihydroxyacetone kinase
C4E05_RS15060	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C4E05_RS15060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4E05_RS15060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS15075	COG2261	transglycosylase associated protein
C4E05_RS15080	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C4E05_RS15090	COG1619	proteins homologs of microcin C7 resistance protein MccF
C4E05_RS15100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4E05_RS15110	COG2719	SpoVR family
C4E05_RS15125	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C4E05_RS15130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4E05_RS15135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4E05_RS15150	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4E05_RS15175	COG2894	cell division
C4E05_RS15225	COG2200	EAL domain
C4E05_RS15250	COG2200	EAL domain
C4E05_RS15255	COG0789	Transcriptional regulator
C4E05_RS15260	COG5562	phage envelope protein
C4E05_RS15275	COG0538	isocitrate dehydrogenase activity
C4E05_RS15280	COG1187	pseudouridine synthase activity
C4E05_RS15300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4E05_RS15305	COG0745	RESPONSE REGULATOR receiver
C4E05_RS15310	COG2205	protein histidine kinase activity
C4E05_RS15315	COG2850	peptidyl-arginine hydroxylation
C4E05_RS15325	COG3842	ATPase activity
C4E05_RS15340	COG0500	methyltransferase
C4E05_RS15370	COG3344	reverse transcriptase
C4E05_RS15505	COG3772	lysozyme
C4E05_RS15545	COG0484	heat shock protein binding
C4E05_RS15550	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C4E05_RS15555	COG1403	HNH endonuclease
C4E05_RS15645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4E05_RS15655	COG0582	viral genome integration into host DNA
C4E05_RS15660	COG1177	transmembrane transport
C4E05_RS15665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4E05_RS15675	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4E05_RS15680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4E05_RS15690	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4E05_RS15695	COG1136	(ABC) transporter
C4E05_RS15700	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4E05_RS15705	COG4763	Acyl-transferase
C4E05_RS15710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4E05_RS15715	COG1376	ErfK ybiS ycfS ynhG family protein
C4E05_RS15715	COG1388	LysM domain
C4E05_RS15725	COG1309	transcriptional regulator
C4E05_RS15730	COG3134	Outer membrane lipoprotein
C4E05_RS15735	COG1252	NADH dehydrogenase
C4E05_RS15755	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C4E05_RS15760	COG5633	Lipoprotein
C4E05_RS15765	COG0537	adenosine 5'-monophosphoramidase activity
C4E05_RS15770	COG4773	Receptor
C4E05_RS15775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS15775	COG1263	PTS System
C4E05_RS15780	COG0084	hydrolase, TatD family'
C4E05_RS15785	COG0470	DNA polymerase III
C4E05_RS15795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4E05_RS15800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4E05_RS15805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4E05_RS15815	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS15820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4E05_RS15840	COG1399	metal-binding, possibly nucleic acid-binding protein
C4E05_RS15845	COG0424	maF-like protein
C4E05_RS15850	COG0564	pseudouridine synthase activity
C4E05_RS15860	COG1530	ribonuclease E activity
C4E05_RS15865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C4E05_RS15870	COG1256	bacterial-type flagellum assembly
C4E05_RS15875	COG1705	Flagellar rod assembly protein muramidase FlgJ
C4E05_RS15875	COG3951	Flagellar rod assembly protein muramidase FlgJ
C4E05_RS15890	COG4786	Flagellar basal body rod
C4E05_RS15895	COG4787	bacterial-type flagellum-dependent cell motility
C4E05_RS15900	COG1749	Flagellar hook protein flgE
C4E05_RS15905	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C4E05_RS15910	COG1558	bacterial-type flagellum-dependent cell motility
C4E05_RS15915	COG1815	bacterial-type flagellum-dependent cell motility
C4E05_RS15920	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C4E05_RS15925	COG2747	anti-sigma28 factor FlgM
C4E05_RS15930	COG3418	PFAM FlgN family protein
C4E05_RS15935	COG0728	peptidoglycan biosynthetic process
C4E05_RS15940	COG0673	inositol 2-dehydrogenase activity
C4E05_RS15950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4E05_RS15960	COG2999	glutathione oxidoreductase activity
C4E05_RS15995	COG3038	cytochrome b561
C4E05_RS16000	COG2353	YceI-like domain
C4E05_RS16010	COG1560	Kdo2-lipid A biosynthetic process
C4E05_RS16025	COG5645	(Lipo)protein
C4E05_RS16030	COG2943	transferase activity, transferring hexosyl groups
C4E05_RS16045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4E05_RS16050	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C4E05_RS16075	COG2197	response regulator
C4E05_RS16090	COG1462	curli production assembly transport component CsgG
C4E05_RS16100	COG3381	protein complex oligomerization
C4E05_RS16140	COG3706	GGDEF domain
C4E05_RS16155	COG0457	Tetratricopeptide repeat
C4E05_RS16160	COG1649	PFAM Uncharacterised BCR, COG1649
C4E05_RS16160	COG0726	polysaccharide deacetylase
C4E05_RS16165	COG1215	transferase activity, transferring glycosyl groups
C4E05_RS16170	COG3658	cytochrome
C4E05_RS16175	COG1702	phosphate starvation-inducible protein PhoH
C4E05_RS16180	COG2837	iron assimilation
C4E05_RS16185	COG2822	iron ion transport
C4E05_RS16195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4E05_RS16205	COG0506	proline dehydrogenase activity
C4E05_RS16205	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4E05_RS16205	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4E05_RS16210	COG1309	transcriptional regulator
C4E05_RS16250	COG2233	PERMEase
C4E05_RS16255	COG3729	General stress protein
C4E05_RS16290	COG3381	protein complex oligomerization
C4E05_RS16295	COG0243	molybdopterin cofactor binding
C4E05_RS16300	COG3005	denitrification pathway
C4E05_RS16305	COG0745	RESPONSE REGULATOR receiver
C4E05_RS16310	COG1879	ABC-type sugar transport system periplasmic component
C4E05_RS16315	COG2205	protein histidine kinase activity
C4E05_RS16315	COG2198	Histidine kinase
C4E05_RS16315	COG0784	Response regulator, receiver
C4E05_RS16320	COG0348	domain, Protein
C4E05_RS16340	COG1278	Cold shock
C4E05_RS16345	COG1278	Cold shock
C4E05_RS16365	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4E05_RS16370	COG1596	polysaccharide export
C4E05_RS16375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4E05_RS16380	COG0489	protein tyrosine kinase activity
C4E05_RS16380	COG3206	protein involved in exopolysaccharide biosynthesis
C4E05_RS16395	COG1294	oxidase, subunit
C4E05_RS16400	COG1271	oxidase subunit
C4E05_RS16405	COG1773	rubredoxin
C4E05_RS16410	COG1999	signal sequence binding
C4E05_RS16415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C4E05_RS16420	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C4E05_RS16425	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C4E05_RS16430	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C4E05_RS16440	COG0670	Belongs to the BI1 family
C4E05_RS16445	COG2920	part of a sulfur-relay system
C4E05_RS16450	COG1254	Belongs to the acylphosphatase family
C4E05_RS16465	COG1832	CoA-binding protein
C4E05_RS16480	COG0210	DNA helicase
C4E05_RS16485	COG3304	Inner membrane component domain
C4E05_RS16490	COG1289	transmembrane transporter activity
C4E05_RS16495	COG3070	regulator of competence-specific genes
C4E05_RS16505	COG2885	chlorophyll binding
C4E05_RS16505	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4E05_RS16515	COG1067	ATP-dependent peptidase activity
C4E05_RS16525	COG3130	regulation of translation
C4E05_RS16530	COG3009	Protein conserved in bacteria
C4E05_RS16535	COG3008	intermembrane lipid transfer
C4E05_RS16535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4E05_RS16540	COG2995	paraquat-inducible protein a
C4E05_RS16545	COG0488	(ABC) transporter
C4E05_RS16555	COG0633	Ferredoxin
C4E05_RS16555	COG3217	Mosc domain protein beta barrel domain protein
C4E05_RS16570	COG3121	Chaperone
C4E05_RS16575	COG3539	Fimbrial protein
C4E05_RS16580	COG3539	Fimbrial protein
C4E05_RS16585	COG3539	Fimbrial protein
C4E05_RS16590	COG3188	usher protein
C4E05_RS16595	COG3121	Chaperone
C4E05_RS16600	COG3539	Fimbrial protein
C4E05_RS16605	COG0431	NADPH-dependent FMN reductase
C4E05_RS16610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4E05_RS16620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E05_RS16625	COG1116	anion transmembrane transporter activity
C4E05_RS16630	COG0308	aminopeptidase N
C4E05_RS16650	COG1448	Aminotransferase
C4E05_RS16655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4E05_RS16660	COG3108	Peptidase M15
C4E05_RS16665	COG2989	Protein conserved in bacteria
C4E05_RS16675	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C4E05_RS16685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4E05_RS16690	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C4E05_RS16695	COG3173	Aminoglycoside phosphotransferase
C4E05_RS16710	COG3214	Protein conserved in bacteria
C4E05_RS16715	COG1663	tetraacyldisaccharide 4'-kinase activity
C4E05_RS16720	COG1132	(ABC) transporter
C4E05_RS16725	COG0658	competence protein
C4E05_RS16725	COG2333	competence protein COMEC
C4E05_RS16735	COG0539	negative regulation of cytoplasmic translation
C4E05_RS16745	COG0501	Belongs to the peptidase M48B family
C4E05_RS16760	COG2323	membrane
C4E05_RS16765	COG1944	ATP diphosphatase activity
C4E05_RS16770	COG2116	formate transmembrane transporter activity
C4E05_RS16775	COG1882	Formate acetyltransferase
C4E05_RS16780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E05_RS16785	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4E05_RS16790	COG0583	DNA-binding transcription factor activity
C4E05_RS16795	COG0531	amino acid
C4E05_RS16805	COG1335	isochorismatase
C4E05_RS16810	COG3302	dmso reductase anchor subunit
C4E05_RS16815	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS16820	COG0243	molybdopterin cofactor binding
C4E05_RS16830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4E05_RS16840	COG1674	ftsk spoiiie
C4E05_RS16840	COG1178	ABC-type Fe3 transport system permease component
C4E05_RS16845	COG1522	sequence-specific DNA binding
C4E05_RS16850	COG0492	ferredoxin-NADP+ reductase activity
C4E05_RS16855	COG4988	ABC transporter
C4E05_RS16860	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C4E05_RS16885	COG0542	response to heat
C4E05_RS16895	COG1278	Cold shock
C4E05_RS16900	COG1136	(ABC) transporter
C4E05_RS16900	COG0577	efflux transmembrane transporter activity
C4E05_RS16905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4E05_RS16910	COG2990	Protein conserved in bacteria
C4E05_RS16915	COG3593	DNA synthesis involved in DNA repair
C4E05_RS16925	COG2431	L-lysine efflux transmembrane transporter activity
C4E05_RS16935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4E05_RS16940	COG0028	Belongs to the TPP enzyme family
C4E05_RS16945	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C4E05_RS16950	COG0702	epimerase
C4E05_RS16955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4E05_RS16960	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4E05_RS16975	COG1126	abc transporter atp-binding protein
C4E05_RS16980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS16985	COG4215	(ABC) transporter
C4E05_RS16990	COG4160	amino acid transport
C4E05_RS16995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS17010	COG1177	transmembrane transport
C4E05_RS17015	COG1176	ABC-type spermidine putrescine transport system, permease component I
C4E05_RS17020	COG3842	ATPase activity
C4E05_RS17025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C4E05_RS17040	COG0778	Nitroreductase
C4E05_RS17050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4E05_RS17065	COG3226	Transcriptional regulator
C4E05_RS17070	COG0738	Major facilitator superfamily
C4E05_RS17075	COG0561	phosphatase activity
C4E05_RS17085	COG2814	Major facilitator Superfamily
C4E05_RS17090	COG0671	phosphoesterase, PA-phosphatase related
C4E05_RS17095	COG1349	DNA-binding transcription factor activity
C4E05_RS17100	COG1686	Belongs to the peptidase S11 family
C4E05_RS17105	COG0625	glutathione transferase activity
C4E05_RS17110	COG2133	pyrroloquinoline quinone binding
C4E05_RS17125	COG2199	diguanylate cyclase activity
C4E05_RS17135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4E05_RS17145	COG0747	negative chemotaxis
C4E05_RS17150	COG4172	Belongs to the ABC transporter superfamily
C4E05_RS17155	COG1446	asparaginase
C4E05_RS17160	COG0303	'Molybdopterin
C4E05_RS17165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4E05_RS17170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E05_RS17175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E05_RS17180	COG1882	Formate acetyltransferase
C4E05_RS17185	COG0561	phosphatase activity
C4E05_RS17195	COG0488	(ABC) transporter
C4E05_RS17200	COG1376	ErfK ybiS ycfS ynhG family protein
C4E05_RS17205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4E05_RS17210	COG1321	iron dependent repressor
C4E05_RS17220	COG2194	sulfuric ester hydrolase activity
C4E05_RS17225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4E05_RS17235	COG5006	permease, DMT superfamily
C4E05_RS17245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS17250	COG0765	amino acid transport
C4E05_RS17255	COG1126	abc transporter atp-binding protein
C4E05_RS17260	COG0668	transmembrane transport
C4E05_RS17275	COG4774	siderophore transport
C4E05_RS17285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4E05_RS17295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4E05_RS17300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4E05_RS17305	COG1199	ATP-dependent helicase activity
C4E05_RS17310	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
C4E05_RS17315	COG0513	Belongs to the DEAD box helicase family
C4E05_RS17320	COG1309	transcriptional regulator
C4E05_RS17330	COG1131	(ABC) transporter
C4E05_RS17335	COG0842	Transport permease protein
C4E05_RS17340	COG0842	Transport permease protein
C4E05_RS17350	COG3568	Endonuclease Exonuclease Phosphatase
C4E05_RS17355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4E05_RS17360	COG0392	lysyltransferase activity
C4E05_RS17365	COG0670	Belongs to the BI1 family
C4E05_RS17370	COG0670	Belongs to the BI1 family
C4E05_RS17375	COG0314	molybdopterin synthase activity
C4E05_RS17380	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4E05_RS17390	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4E05_RS17400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C4E05_RS17410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4E05_RS17415	COG2226	methyltransferase
C4E05_RS17430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4E05_RS17435	COG1881	PFAM PEBP family protein
C4E05_RS17440	COG4677	pectinesterase activity
C4E05_RS17445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4E05_RS17450	COG0471	metal ion transport
C4E05_RS17455	COG2828	Protein conserved in bacteria
C4E05_RS17460	COG0583	DNA-binding transcription factor activity
C4E05_RS17470	COG0561	phosphatase activity
C4E05_RS17475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4E05_RS17480	COG4149	molybdate abc transporter
C4E05_RS17485	COG0725	ABC transporter, periplasmic molybdate-binding protein
C4E05_RS17495	COG3585	molybdate ion transport
C4E05_RS17495	COG2005	Transcriptional regulator
C4E05_RS17500	COG1119	ATPase activity
C4E05_RS17505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4E05_RS17510	COG1085	galactose-1-phosphate uridylyltransferase
C4E05_RS17520	COG2017	converts alpha-aldose to the beta-anomer
C4E05_RS17530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4E05_RS17540	COG1230	cation diffusion facilitator family transporter
C4E05_RS17545	COG3201	nicotinamide mononucleotide transporter
C4E05_RS17595	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C4E05_RS17600	COG2885	chlorophyll binding
C4E05_RS17610	COG3064	Membrane
C4E05_RS17615	COG0848	biopolymer transport protein
C4E05_RS17620	COG0811	peptide transport
C4E05_RS17625	COG0824	Thioesterase
C4E05_RS17630	COG3790	cyd operon protein YbgE
C4E05_RS17635	COG4890	Cyd operon protein YbgT
C4E05_RS17640	COG1294	oxidase, subunit
C4E05_RS17645	COG1271	oxidase subunit
C4E05_RS17650	COG0383	alpha-mannosidase activity
C4E05_RS17655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS17655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS17655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS17660	COG2188	Transcriptional regulator
C4E05_RS17665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4E05_RS17675	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4E05_RS17680	COG0567	Dehydrogenase, E1 component
C4E05_RS17685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4E05_RS17690	COG1053	succinate dehydrogenase
C4E05_RS17695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4E05_RS17700	COG2009	succinate dehydrogenase
C4E05_RS17710	COG0372	Belongs to the citrate synthase family
C4E05_RS17715	COG3539	Fimbrial protein
C4E05_RS17720	COG3188	usher protein
C4E05_RS17725	COG3121	Chaperone
C4E05_RS17730	COG3539	Fimbrial protein
C4E05_RS17735	COG3180	Ammonia monooxygenase
C4E05_RS17750	COG1984	allophanate hydrolase subunit 2
C4E05_RS17755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C4E05_RS17760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4E05_RS17765	COG3104	oligopeptide transport
C4E05_RS17770	COG0415	Belongs to the DNA photolyase family
C4E05_RS17775	COG3272	Protein of unknown function (DUF1722)
C4E05_RS17810	COG3209	COG3209 Rhs family protein
C4E05_RS17840	COG2205	protein histidine kinase activity
C4E05_RS17845	COG0745	RESPONSE REGULATOR receiver
C4E05_RS17860	COG0531	amino acid
C4E05_RS17880	COG0033	Phosphoglucomutase
C4E05_RS17885	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C4E05_RS17890	COG0596	Alpha beta hydrolase
C4E05_RS17900	COG0716	FMN binding
C4E05_RS17910	COG0735	belongs to the Fur family
C4E05_RS17930	COG1263	PTS System
C4E05_RS17930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS17930	COG2190	(PTS) system
C4E05_RS17940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4E05_RS17945	COG1846	Transcriptional regulator
C4E05_RS17945	COG1940	carbohydrate kinase activity
C4E05_RS17950	COG0647	UMP catabolic process
C4E05_RS17955	COG0367	asparagine synthase
C4E05_RS17995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4E05_RS18005	COG1702	phosphate starvation-inducible protein PhoH
C4E05_RS18015	COG4535	Mg2 and Co2 transporter CorC
C4E05_RS18020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4E05_RS18025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4E05_RS18030	COG0765	amino acid transport
C4E05_RS18035	COG0765	amino acid transport
C4E05_RS18040	COG1126	abc transporter atp-binding protein
C4E05_RS18050	COG0443	Heat shock 70 kDa protein
C4E05_RS18055	COG2214	Heat shock protein DnaJ domain protein
C4E05_RS18065	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4E05_RS18070	COG2214	Heat shock protein DnaJ domain protein
C4E05_RS18080	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4E05_RS18085	COG2888	peptidyl-tyrosine sulfation
C4E05_RS18100	COG1466	dna polymerase III delta subunit
C4E05_RS18110	COG0406	alpha-ribazole phosphatase activity
C4E05_RS18115	COG0799	negative regulation of ribosome biogenesis
C4E05_RS18125	COG0768	penicillin binding
C4E05_RS18130	COG0772	Belongs to the SEDS family
C4E05_RS18135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4E05_RS18140	COG1686	Belongs to the peptidase S11 family
C4E05_RS18155	COG0583	DNA-binding transcription factor activity
C4E05_RS18165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4E05_RS18190	COG3069	C4-dicarboxylate transmembrane transporter activity
C4E05_RS18195	COG4565	transcriptional regulatory protein
C4E05_RS18200	COG3290	protein histidine kinase activity
C4E05_RS18205	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C4E05_RS18215	COG2301	Belongs to the HpcH HpaI aldolase family
C4E05_RS18220	COG3051	citrate lyase alpha subunit
C4E05_RS18235	COG0471	metal ion transport
C4E05_RS18240	COG3719	Belongs to the RNase T2 family
C4E05_RS18245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4E05_RS18250	COG1063	alcohol dehydrogenase
C4E05_RS18255	COG0589	response to stress
C4E05_RS18260	COG3634	alkyl hydroperoxide reductase activity
C4E05_RS18265	COG0450	alkyl hydroperoxide reductase
C4E05_RS18270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4E05_RS18275	COG0583	DNA-binding transcription factor activity
C4E05_RS18280	COG3969	phosphoadenosine phosphosulfate
C4E05_RS18285	COG1475	DNA binding
C4E05_RS18290	COG0436	Aminotransferase
C4E05_RS18295	COG0371	Dehydrogenase
C4E05_RS18300	COG2879	small protein
C4E05_RS18305	COG1966	Carbon starvation protein
C4E05_RS18310	COG2050	protein possibly involved in aromatic compounds catabolism
C4E05_RS18315	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS18320	COG1535	isochorismatase
C4E05_RS18320	COG3433	isochorismatase activity
C4E05_RS18325	COG1021	2,3-dihydroxybenzoate-AMP ligase
C4E05_RS18330	COG1169	isochorismate synthase
C4E05_RS18335	COG4592	Periplasmic binding protein
C4E05_RS18345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E05_RS18350	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E05_RS18355	COG1120	ATPase activity
C4E05_RS18360	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C4E05_RS18365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4E05_RS18365	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C4E05_RS18370	COG3251	PFAM MbtH domain protein
C4E05_RS18375	COG2382	esterase
C4E05_RS18385	COG4771	TonB-dependent receptor
C4E05_RS18390	COG2977	Belongs to the P-Pant transferase superfamily
C4E05_RS18395	COG3385	transposase activity
C4E05_RS18440	COG3423	Transcriptional regulator
C4E05_RS18460	COG0500	methyltransferase
C4E05_RS18465	COG0438	transferase activity, transferring glycosyl groups
C4E05_RS18470	COG0438	transferase activity, transferring glycosyl groups
C4E05_RS18515	COG0778	Nitroreductase
C4E05_RS18520	COG0668	transmembrane transport
C4E05_RS18525	COG1113	amino acid transport
C4E05_RS18530	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4E05_RS18535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4E05_RS18540	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4E05_RS18545	COG1538	Outer membrane efflux protein
C4E05_RS18550	COG0745	RESPONSE REGULATOR receiver
C4E05_RS18555	COG5002	protein histidine kinase activity
C4E05_RS18560	COG1215	transferase activity, transferring glycosyl groups
C4E05_RS18565	COG4783	chaperone-mediated protein folding
C4E05_RS18575	COG2207	Transcriptional regulator
C4E05_RS18585	COG2197	response regulator
C4E05_RS18590	COG3539	Fimbrial protein
C4E05_RS18595	COG3539	Fimbrial protein
C4E05_RS18600	COG3188	usher protein
C4E05_RS18605	COG3121	Chaperone
C4E05_RS18610	COG3539	Fimbrial protein
C4E05_RS18620	COG2501	S4 domain
C4E05_RS18625	COG1988	membrane-bound metal-dependent
C4E05_RS18635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4E05_RS18645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C4E05_RS18650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C4E05_RS18655	COG0549	Belongs to the carbamate kinase family
C4E05_RS18665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4E05_RS18670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4E05_RS18675	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C4E05_RS18680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4E05_RS18685	COG3257	ureidoglycine aminohydrolase activity
C4E05_RS18690	COG1929	Belongs to the glycerate kinase type-1 family
C4E05_RS18695	COG2233	PERMEase
C4E05_RS18705	COG1953	Uracil, thiamine, allantoin
C4E05_RS18710	COG2084	Dehydrogenase
C4E05_RS18720	COG3960	tartronate-semialdehyde synthase activity
C4E05_RS18725	COG1414	Transcriptional regulator
C4E05_RS18735	COG0583	DNA-binding transcription factor activity
C4E05_RS18765	COG3209	COG3209 Rhs family protein
C4E05_RS18770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4E05_RS18775	COG4181	ATPase activity
C4E05_RS18780	COG2755	lipolytic protein G-D-S-L family
C4E05_RS18785	COG0300	oxidoreductase activity
C4E05_RS18790	COG3118	belongs to the thioredoxin family
C4E05_RS18795	COG0390	transport system, permease component
C4E05_RS18800	COG4619	ABC transporter
C4E05_RS18805	COG0330	HflC and HflK could
C4E05_RS18810	COG1585	Membrane protein implicated in regulation of membrane protease activity
C4E05_RS18815	COG0789	Transcriptional regulator
C4E05_RS18820	COG0531	amino acid
C4E05_RS18825	COG2066	Belongs to the glutaminase family
C4E05_RS18830	COG2217	Heavy metal translocating P-type atpase
C4E05_RS18835	COG3093	addiction module antidote protein HigA
C4E05_RS18845	COG3735	TraB family
C4E05_RS18850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4E05_RS18855	COG0737	Belongs to the 5'-nucleotidase family
C4E05_RS18860	COG2223	nitrite transmembrane transporter activity
C4E05_RS18865	COG4651	solute:proton antiporter activity
C4E05_RS18865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4E05_RS18870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS18910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4E05_RS18920	COG2832	Protein of unknown function (DUF454)
C4E05_RS18925	COG3923	Primosomal replication protein n
C4E05_RS18935	COG1196	nuclear chromosome segregation
C4E05_RS18935	COG3264	Mechanosensitive ion channel
C4E05_RS18945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4E05_RS18950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4E05_RS18965	COG0110	maltose O-acetyltransferase activity
C4E05_RS18975	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4E05_RS18980	COG5507	3-demethylubiquinone-9 3-methyltransferase
C4E05_RS18990	COG3695	enzyme binding
C4E05_RS18995	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C4E05_RS19000	COG1946	Acyl-CoA thioesterase
C4E05_RS19005	COG0004	ammonium transporteR
C4E05_RS19010	COG0347	Belongs to the P(II) protein family
C4E05_RS19015	COG1132	(ABC) transporter
C4E05_RS19020	COG1132	(ABC) transporter
C4E05_RS19025	COG1522	sequence-specific DNA binding
C4E05_RS19035	COG4533	DNA binding
C4E05_RS19045	COG0824	Thioesterase
C4E05_RS19050	COG1555	photosystem II stabilization
C4E05_RS19055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E05_RS19060	COG0776	regulation of translation
C4E05_RS19065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4E05_RS19085	COG0271	Belongs to the BolA IbaG family
C4E05_RS19090	COG3056	Lipoprotein
C4E05_RS19095	COG2223	nitrite transmembrane transporter activity
C4E05_RS19100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4E05_RS19105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4E05_RS19110	COG1845	cytochrome c oxidase, subunit III
C4E05_RS19115	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C4E05_RS19125	COG2814	Major facilitator Superfamily
C4E05_RS19135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C4E05_RS19140	COG0693	protein deglycase activity
C4E05_RS19155	COG0142	geranyltranstransferase activity
C4E05_RS19165	COG0667	Aldo Keto reductase
C4E05_RS19170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4E05_RS19175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4E05_RS19190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4E05_RS19190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4E05_RS19200	COG4238	major outer membrane lipoprotein
C4E05_RS19205	COG3248	Nucleoside-binding outer membrane protein
C4E05_RS19210	COG1403	HNH endonuclease
C4E05_RS19215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4E05_RS19220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4E05_RS19225	COG1862	Preprotein translocase
C4E05_RS19245	COG0366	Alpha amylase catalytic
C4E05_RS19250	COG1113	amino acid transport
C4E05_RS19255	COG1114	Component of the transport system for branched-chain amino acids
C4E05_RS19260	COG5002	protein histidine kinase activity
C4E05_RS19265	COG0745	RESPONSE REGULATOR receiver
C4E05_RS19270	COG0420	3'-5' exonuclease activity
C4E05_RS19275	COG0419	ATPase involved in DNA repair
C4E05_RS19280	COG2814	Major facilitator Superfamily
C4E05_RS19285	COG1940	carbohydrate kinase activity
C4E05_RS19310	COG4126	flavin adenine dinucleotide binding
C4E05_RS19330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C4E05_RS19335	COG3706	GGDEF domain
C4E05_RS19345	COG1785	Belongs to the alkaline phosphatase family
C4E05_RS19355	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4E05_RS19375	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C4E05_RS19380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4E05_RS19385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4E05_RS19390	COG3468	outer membrane autotransporter barrel domain protein
C4E05_RS19395	COG0113	porphobilinogen synthase activity
C4E05_RS19400	COG2175	clavaminate synthase activity
C4E05_RS19405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4E05_RS19415	COG4521	taurine ABC transporter
C4E05_RS19425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C4E05_RS19430	COG1215	transferase activity, transferring glycosyl groups
C4E05_RS19455	COG3547	Transposase (IS116 IS110 IS902 family)
C4E05_RS19475	COG3122	Protein conserved in bacteria
C4E05_RS19480	COG2814	Major facilitator Superfamily
C4E05_RS19495	COG3971	2-oxopent-4-enoate hydratase activity
C4E05_RS19515	COG1414	Transcriptional regulator
C4E05_RS19520	COG1609	Transcriptional regulator
C4E05_RS19525	COG3250	beta-galactosidase activity
C4E05_RS19530	COG2223	nitrite transmembrane transporter activity
C4E05_RS19535	COG0110	maltose O-acetyltransferase activity
C4E05_RS19540	COG2807	transmembrane transport
C4E05_RS19550	COG0288	reversible hydration of carbon dioxide
C4E05_RS19555	COG0583	DNA-binding transcription factor activity
C4E05_RS19560	COG0402	S-adenosylhomocysteine deaminase activity
C4E05_RS19565	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4E05_RS19570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4E05_RS19575	COG2079	MmgE PrpD family protein
C4E05_RS19580	COG0372	Belongs to the citrate synthase family
C4E05_RS19585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C4E05_RS19590	COG3829	transcription factor binding
C4E05_RS19600	COG1280	lysine exporter protein (LysE YggA)
C4E05_RS19615	COG1064	alcohol dehydrogenase
C4E05_RS19620	COG0402	S-adenosylhomocysteine deaminase activity
C4E05_RS19625	COG0549	Belongs to the carbamate kinase family
C4E05_RS19635	COG1304	FMN binding
C4E05_RS19640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4E05_RS19650	COG0666	response to abiotic stimulus
C4E05_RS19660	COG0583	DNA-binding transcription factor activity
C4E05_RS19665	COG2771	luxR family
C4E05_RS19665	COG2200	EAL domain
C4E05_RS19675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4E05_RS19700	COG1556	Lactate utilization protein
C4E05_RS19705	COG1139	Iron-sulfur cluster binding protein
C4E05_RS19710	COG0247	lactate metabolic process
C4E05_RS19715	COG2207	Transcriptional regulator
C4E05_RS19720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E05_RS19730	COG3059	membrane
C4E05_RS19740	COG3708	Transcriptional regulator
C4E05_RS19740	COG2207	Transcriptional regulator
C4E05_RS19745	COG1388	LysM domain
C4E05_RS19790	COG3188	usher protein
C4E05_RS19800	COG3121	Chaperone
C4E05_RS19805	COG0727	PFAM Uncharacterised protein family (UPF0153)
C4E05_RS19810	COG3477	response to acidic pH
C4E05_RS19815	COG2080	2 iron, 2 sulfur cluster binding
C4E05_RS19820	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C4E05_RS19825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4E05_RS19830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4E05_RS19835	COG0583	DNA-binding transcription factor activity
C4E05_RS19860	COG2003	Belongs to the UPF0758 family
C4E05_RS19895	COG2020	methyltransferase activity
C4E05_RS20015	COG3344	reverse transcriptase
C4E05_RS20100	COG3811	Belongs to the UPF0386 family
C4E05_RS20140	COG0582	viral genome integration into host DNA
C4E05_RS20180	COG5301	cellulose 1,4-beta-cellobiosidase activity
C4E05_RS20255	COG0740	serine-type endopeptidase activity
C4E05_RS20295	COG3772	lysozyme
C4E05_RS20330	COG1403	HNH endonuclease
C4E05_RS20340	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C4E05_RS20350	COG4725	Belongs to the MT-A70-like family
C4E05_RS20360	COG1846	Transcriptional regulator
C4E05_RS20405	COG5532	Uncharacterized conserved protein (DUF2303)
C4E05_RS20410	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C4E05_RS20430	COG0582	viral genome integration into host DNA
C4E05_RS20450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C4E05_RS20470	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4E05_RS20475	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4E05_RS20480	COG1690	Belongs to the RtcB family
C4E05_RS20485	COG0454	-acetyltransferase
C4E05_RS20495	COG2161	toxin-antitoxin pair type II binding
C4E05_RS20515	COG1943	Transposase
C4E05_RS20520	COG0791	NLP P60 protein
C4E05_RS20525	COG3077	Addiction module antitoxin, RelB DinJ family
C4E05_RS20530	COG3041	Addiction module toxin RelE StbE family
C4E05_RS20535	COG3034	peptidoglycan biosynthetic process
C4E05_RS20540	COG0121	glutamine amidotransferase
C4E05_RS20550	COG1960	acyl-CoA dehydrogenase activity
C4E05_RS20560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4E05_RS20565	COG5433	transposase activity
C4E05_RS20575	COG3209	COG3209 Rhs family protein
C4E05_RS20665	COG3157	Type VI secretion system effector, Hcp
C4E05_RS20670	COG4104	PAAR repeat-containing protein
C4E05_RS20690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4E05_RS20700	COG2226	methyltransferase
C4E05_RS20710	COG1388	LysM domain
C4E05_RS20710	COG0741	lytic transglycosylase activity
C4E05_RS20715	COG2226	methyltransferase
C4E05_RS20725	COG0583	DNA-binding transcription factor activity
C4E05_RS20730	COG0656	L-ascorbic acid biosynthetic process
C4E05_RS20765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4E05_RS20770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4E05_RS20775	COG2011	ABC-type metal ion transport system permease component
C4E05_RS20780	COG1464	Belongs to the NlpA lipoprotein family
C4E05_RS20790	COG1720	tRNA m6t6A37 methyltransferase activity
C4E05_RS20800	COG0791	NLP P60 protein
C4E05_RS20805	COG3015	lipoprotein NlpE involved in copper resistance
C4E05_RS20810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C4E05_RS20815	COG4681	YaeQ
C4E05_RS20825	COG4568	rho-dependent transcription termination
C4E05_RS20830	COG0037	tRNA processing
C4E05_RS20835	COG0346	lactoylglutathione lyase activity
C4E05_RS20840	COG1982	Orn Lys Arg decarboxylase major
C4E05_RS20850	COG0587	DNA-directed DNA polymerase activity
C4E05_RS20875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4E05_RS20880	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C4E05_RS20890	COG0750	zinc metalloprotease
C4E05_RS20895	COG0575	Belongs to the CDS family
C4E05_RS20900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4E05_RS20905	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4E05_RS20930	COG0024	Methionine aminopeptidase
C4E05_RS20945	COG1408	metallophosphoesterase
C4E05_RS20960	COG3835	regulator
C4E05_RS20965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4E05_RS20980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4E05_RS20985	COG2860	membrane
C4E05_RS21010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E05_RS21015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C4E05_RS21020	COG1120	ATPase activity
C4E05_RS21025	COG4774	siderophore transport
C4E05_RS21030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4E05_RS21035	COG1643	Atp-dependent helicase
C4E05_RS21040	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4E05_RS21050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4E05_RS21060	COG0617	tRNA 3'-terminal CCA addition
C4E05_RS21065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4E05_RS21070	COG3539	Fimbrial protein
C4E05_RS21075	COG3121	Chaperone
C4E05_RS21080	COG3188	usher protein
C4E05_RS21085	COG3539	Fimbrial protein
C4E05_RS21090	COG3539	Fimbrial protein
C4E05_RS21095	COG3539	Fimbrial protein
C4E05_RS21100	COG3539	Fimbrial protein
C4E05_RS21115	COG5464	transposase or invertase
C4E05_RS21125	COG0726	polysaccharide deacetylase
C4E05_RS21130	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS21135	COG0842	Transport permease protein
C4E05_RS21140	COG1131	(ABC) transporter
C4E05_RS21145	COG0288	reversible hydration of carbon dioxide
C4E05_RS21150	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4E05_RS21155	COG4993	Dehydrogenase
C4E05_RS21160	COG2132	Multicopper oxidase
C4E05_RS21185	COG1049	propionate catabolic process, 2-methylcitrate cycle
C4E05_RS21190	COG3064	Membrane
C4E05_RS21195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4E05_RS21200	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4E05_RS21205	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C4E05_RS21210	COG2186	Transcriptional regulator
C4E05_RS21215	COG1113	amino acid transport
C4E05_RS21220	COG3725	Membrane protein required for beta-lactamase induction
C4E05_RS21225	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4E05_RS21230	COG0157	Belongs to the NadC ModD family
C4E05_RS21235	COG4969	Belongs to the N-Me-Phe pilin family
C4E05_RS21240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4E05_RS21245	COG1459	type II secretion system
C4E05_RS21255	COG0237	dephospho-CoA kinase activity
C4E05_RS21270	COG0494	nUDIX hydrolase
C4E05_RS21290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4E05_RS21295	COG0849	cell division
C4E05_RS21300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4E05_RS21305	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4E05_RS21320	COG0772	Belongs to the SEDS family
C4E05_RS21335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4E05_RS21340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4E05_RS21345	COG0768	penicillin binding
C4E05_RS21350	COG3116	cell division
C4E05_RS21360	COG2001	Belongs to the MraZ family
C4E05_RS21365	COG1609	Transcriptional regulator
C4E05_RS21375	COG0440	acetolactate synthase activity
C4E05_RS21380	COG0028	Belongs to the TPP enzyme family
C4E05_RS21390	COG0583	DNA-binding transcription factor activity
C4E05_RS21405	COG0473	3-isopropylmalate dehydrogenase activity
C4E05_RS21420	COG2814	Major facilitator Superfamily
C4E05_RS21430	COG4533	DNA binding
C4E05_RS21435	COG4143	(ABC) transporter
C4E05_RS21440	COG1178	ABC-type Fe3 transport system permease component
C4E05_RS21445	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C4E05_RS21450	COG0586	Pfam SNARE associated Golgi protein
C4E05_RS21455	COG4977	sequence-specific DNA binding
C4E05_RS21460	COG1069	ribulokinase activity
C4E05_RS21465	COG2160	L-arabinose isomerase activity
C4E05_RS21470	COG0235	Class ii aldolase
C4E05_RS21475	COG0417	DNA replication proofreading
C4E05_RS21485	COG0564	pseudouridine synthase activity
C4E05_RS21500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4E05_RS21505	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4E05_RS21510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E05_RS21535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C4E05_RS21550	COG2271	Major facilitator Superfamily
C4E05_RS21555	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C4E05_RS21560	COG0644	oxidoreductase
C4E05_RS21610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4E05_RS21615	COG0505	Belongs to the CarA family
C4E05_RS21635	COG1047	Peptidyl-prolyl cis-trans
C4E05_RS21650	COG0196	riboflavin kinase activity
C4E05_RS21680	COG0583	DNA-binding transcription factor activity
C4E05_RS21700	COG3385	transposase activity
C4E05_RS21720	COG4735	regulation of single-species biofilm formation
C4E05_RS21725	COG1584	GPR1 FUN34 yaaH family protein
C4E05_RS21730	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4E05_RS21735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E05_RS21740	COG1115	amino acid carrier protein
C4E05_RS21755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4E05_RS21765	COG0460	homoserine dehydrogenase
C4E05_RS21765	COG0527	aspartate kinase activity
C4E05_RS21775	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C4E05_RS21785	COG0745	RESPONSE REGULATOR receiver
C4E05_RS21790	COG4452	Inner membrane protein CreD
C4E05_RS21795	COG2205	protein histidine kinase activity
C4E05_RS21800	COG0745	RESPONSE REGULATOR receiver
C4E05_RS21805	COG3045	CreA protein
C4E05_RS21810	COG3708	Transcriptional regulator
C4E05_RS21810	COG2207	Transcriptional regulator
C4E05_RS21830	COG0741	lytic transglycosylase activity
C4E05_RS21835	COG0488	(ABC) transporter
C4E05_RS21840	COG3172	ATPase kinase involved in NAD metabolism
C4E05_RS21840	COG1056	cytidyltransferase-related domain
C4E05_RS21845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C4E05_RS21850	COG0560	Phosphoserine phosphatase
C4E05_RS21855	COG3726	membrane protein affecting hemolysin expression
C4E05_RS21885	COG1328	CTP reductase activity
C4E05_RS21890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E05_RS21895	COG0084	hydrolase, TatD family'
C4E05_RS21900	COG4667	esterase of the alpha-beta hydrolase superfamily
C4E05_RS21910	COG2823	Periplasmic or secreted lipoprotein
C4E05_RS21920	COG1011	Hydrolase
C4E05_RS21925	COG0456	acetyltransferase
C4E05_RS21930	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C4E05_RS21960	COG4114	ferric iron reductase
C4E05_RS21965	COG2197	response regulator
C4E05_RS21970	COG2197	response regulator
C4E05_RS21975	COG2966	Psort location CytoplasmicMembrane, score
C4E05_RS21990	COG1484	DNA-dependent DNA replication
C4E05_RS22005	COG1063	alcohol dehydrogenase
C4E05_RS22010	COG1802	Transcriptional regulator
C4E05_RS22015	COG2271	Major facilitator Superfamily
C4E05_RS22020	COG0840	transmembrane signaling receptor activity
C4E05_RS22025	COG1966	Carbon starvation protein
C4E05_RS22030	COG2879	small protein
C4E05_RS22035	COG0523	cobalamin synthesis protein
C4E05_RS22055	COG2814	Major facilitator Superfamily
C4E05_RS22060	COG2733	membrane
C4E05_RS22065	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C4E05_RS22070	COG1924	4 iron, 4 sulfur cluster binding
C4E05_RS22095	COG3366	ferrous iron transmembrane transporter activity
C4E05_RS22100	COG0700	Nucleoside recognition
C4E05_RS22105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C4E05_RS22110	COG0583	DNA-binding transcription factor activity
C4E05_RS22130	COG2186	Transcriptional regulator
C4E05_RS22135	COG0246	Mannitol dehydrogenase
C4E05_RS22145	COG2610	gluconate transmembrane transporter activity
C4E05_RS22165	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4E05_RS22195	COG3436	PFAM IS66 Orf2 family protein
C4E05_RS22200	COG4372	Transposase
C4E05_RS22240	COG1595	DNA-templated transcription, initiation
C4E05_RS22245	COG3712	iron ion homeostasis
C4E05_RS22250	COG4772	TonB-dependent receptor
C4E05_RS22255	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C4E05_RS22260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E05_RS22265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4E05_RS22270	COG1120	ATPase activity
C4E05_RS22275	COG2085	NADP oxidoreductase coenzyme F420-dependent
C4E05_RS22285	COG3344	reverse transcriptase
C4E05_RS22305	COG1309	transcriptional regulator
C4E05_RS22325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4E05_RS22340	COG2990	Protein conserved in bacteria
C4E05_RS22345	COG0297	glycogen (starch) synthase activity
C4E05_RS22350	COG0726	polysaccharide deacetylase
C4E05_RS22365	COG3344	reverse transcriptase
C4E05_RS22445	COG0582	viral genome integration into host DNA
C4E05_RS22455	COG1064	alcohol dehydrogenase
C4E05_RS22460	COG0433	COG0433 Predicted ATPase
C4E05_RS22465	COG0795	lipopolysaccharide-transporting ATPase activity
C4E05_RS22470	COG0795	lipopolysaccharide-transporting ATPase activity
C4E05_RS22480	COG2927	DNA polymerase III (CHI subunit)
C4E05_RS22495	COG0456	acetyltransferase
C4E05_RS22500	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C4E05_RS22515	COG2731	YhcH YjgK YiaL family protein
C4E05_RS22520	COG1309	transcriptional regulator
C4E05_RS22525	COG1028	Short-chain dehydrogenase reductase Sdr
C4E05_RS22530	COG0251	oxidation-reduction process
C4E05_RS22550	COG0251	oxidation-reduction process
C4E05_RS22555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4E05_RS22565	COG1609	Transcriptional regulator
C4E05_RS22570	COG1263	PTS System
C4E05_RS22570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS22575	COG0366	Alpha amylase catalytic
C4E05_RS22580	COG1328	CTP reductase activity
C4E05_RS22585	COG0602	queuosine metabolic process
C4E05_RS22590	COG3783	Cytochrome b(562)
C4E05_RS22595	COG0312	modulator of DNA gyrase
C4E05_RS22605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4E05_RS22615	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4E05_RS22620	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4E05_RS22625	COG1129	ABC transporter
C4E05_RS22630	COG1879	ABC-type sugar transport system periplasmic component
C4E05_RS22635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4E05_RS22640	COG2337	Toxic component of a toxin-antitoxin (TA) module
C4E05_RS22645	COG2336	PFAM SpoVT AbrB
C4E05_RS22650	COG2105	PFAM AIG2 family protein
C4E05_RS22655	COG2911	Protein conserved in bacteria
C4E05_RS22660	COG0729	surface antigen
C4E05_RS22670	COG1253	flavin adenine dinucleotide binding
C4E05_RS22680	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C4E05_RS22690	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4E05_RS22695	COG0737	Belongs to the 5'-nucleotidase family
C4E05_RS22700	COG1733	regulation of RNA biosynthetic process
C4E05_RS22705	COG0702	epimerase
C4E05_RS22710	COG0697	spore germination
C4E05_RS22720	COG1113	amino acid transport
C4E05_RS22725	COG0545	Peptidyl-prolyl cis-trans isomerase
C4E05_RS22735	COG3061	Opacity-associated protein A
C4E05_RS22745	COG0675	Transposase, IS605 OrfB family
C4E05_RS22770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4E05_RS22790	COG3477	response to acidic pH
C4E05_RS22795	COG0235	Class ii aldolase
C4E05_RS22810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS22815	COG3414	Phosphotransferase system galactitol-specific IIB component
C4E05_RS22835	COG1073	alpha beta
C4E05_RS22840	COG3650	response to hydrogen peroxide
C4E05_RS22850	COG1960	acyl-CoA dehydrogenase activity
C4E05_RS22855	COG0754	glutathionylspermidine amidase activity
C4E05_RS22860	COG5463	Belongs to the UPF0441 family
C4E05_RS22865	COG3766	membrane
C4E05_RS22885	COG2721	sulfolactate sulfo-lyase activity
C4E05_RS22890	COG2271	Major facilitator Superfamily
C4E05_RS22895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4E05_RS22900	COG1414	Transcriptional regulator
C4E05_RS22905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4E05_RS22915	COG0557	exoribonuclease II activity
C4E05_RS22930	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C4E05_RS22935	COG0330	HflC and HflK could
C4E05_RS22940	COG0330	HflC and HflK could
C4E05_RS22945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4E05_RS22965	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4E05_RS22970	COG0802	atpase or kinase
C4E05_RS22975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4E05_RS22975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4E05_RS22980	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4E05_RS23020	COG3264	Mechanosensitive ion channel
C4E05_RS23020	COG1511	domain protein
C4E05_RS23035	COG0531	amino acid
C4E05_RS23045	COG1053	succinate dehydrogenase
C4E05_RS23050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4E05_RS23065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C4E05_RS23070	COG3040	lipid binding
C4E05_RS23075	COG2076	Multidrug Resistance protein
C4E05_RS23080	COG5510	response to toxic substance
C4E05_RS23085	COG5510	response to toxic substance
C4E05_RS23095	COG1509	lysine 2,3-aminomutase activity
C4E05_RS23120	COG0531	amino acid
C4E05_RS23125	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4E05_RS23130	COG1027	Aspartate ammonia-lyase
C4E05_RS23135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C4E05_RS23145	COG4232	protein-disulfide reductase activity
C4E05_RS23150	COG1309	transcriptional regulator
C4E05_RS23160	COG3710	Transcriptional regulator
C4E05_RS23165	COG0531	amino acid
C4E05_RS23170	COG1982	Orn Lys Arg decarboxylase major
C4E05_RS23175	COG3104	oligopeptide transport
C4E05_RS23180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4E05_RS23195	COG2388	GCN5-related N-acetyl-transferase
C4E05_RS23200	COG3592	Divergent 4Fe-4S mono-cluster
C4E05_RS23205	COG3290	protein histidine kinase activity
C4E05_RS23210	COG4565	transcriptional regulatory protein
C4E05_RS23215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C4E05_RS23220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4E05_RS23220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C4E05_RS23225	COG3647	Membrane
C4E05_RS23230	COG2211	Major facilitator Superfamily
C4E05_RS23235	COG1486	melibiose metabolic process
C4E05_RS23240	COG2169	Transcriptional regulator
C4E05_RS23245	COG1982	Orn Lys Arg decarboxylase major
C4E05_RS23250	COG2207	Transcriptional regulator
C4E05_RS23255	COG0531	amino acid
C4E05_RS23260	COG2194	sulfuric ester hydrolase activity
C4E05_RS23265	COG0745	RESPONSE REGULATOR receiver
C4E05_RS23270	COG0642	Histidine kinase
C4E05_RS23280	COG0477	Major facilitator Superfamily
C4E05_RS23295	COG2824	Alkylphosphonate utilization operon protein PhnA
C4E05_RS23300	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C4E05_RS23305	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C4E05_RS23310	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C4E05_RS23320	COG2188	Transcriptional regulator
C4E05_RS23325	COG3624	Phosphonate C-P lyase system protein PhnG
C4E05_RS23330	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C4E05_RS23335	COG3626	phosphonate metabolism
C4E05_RS23340	COG3627	carbon phosphorus lyase activity
C4E05_RS23345	COG4107	phosphonate C-P lyase system protein PhnK
C4E05_RS23350	COG4778	phosphonate C-P lyase system protein PhnL
C4E05_RS23355	COG3454	Phosphonate metabolism
C4E05_RS23360	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C4E05_RS23365	COG0456	acetyltransferase
C4E05_RS23370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C4E05_RS23380	COG0698	ribose 5-phosphate isomerase
C4E05_RS23385	COG1737	Transcriptional regulator
C4E05_RS23390	COG1879	ABC-type sugar transport system periplasmic component
C4E05_RS23395	COG1129	ABC transporter
C4E05_RS23400	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4E05_RS23405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4E05_RS23410	COG1940	carbohydrate kinase activity
C4E05_RS23415	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C4E05_RS23425	COG1566	PFAM secretion protein HlyD family protein
C4E05_RS23430	COG1289	transmembrane transporter activity
C4E05_RS23435	COG1538	Outer membrane efflux protein
C4E05_RS23445	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C4E05_RS23450	COG1301	dicarboxylic acid transport
C4E05_RS23455	COG4235	cytochrome complex assembly
C4E05_RS23460	COG3088	subunit of a heme lyase
C4E05_RS23465	COG1138	Cytochrome C-type biogenesis protein
C4E05_RS23470	COG3301	Polysulphide reductase, NrfD
C4E05_RS23475	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS23480	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C4E05_RS23490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4E05_RS23495	COG3162	membrane
C4E05_RS23505	COG1357	PFAM Pentapeptide repeats (8 copies)
C4E05_RS23510	COG0025	NhaP-type Na H and K H
C4E05_RS23515	COG2252	PERMEase
C4E05_RS23520	COG0789	Transcriptional regulator
C4E05_RS23525	COG2207	Transcriptional regulator
C4E05_RS23530	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4E05_RS23575	COG0629	single-stranded DNA binding
C4E05_RS23580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4E05_RS23585	COG2315	Protein conserved in bacteria
C4E05_RS23590	COG0432	Pfam Uncharacterised protein family UPF0047
C4E05_RS23595	COG3700	Belongs to the class B bacterial acid phosphatase family
C4E05_RS23605	COG1448	Aminotransferase
C4E05_RS23610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4E05_RS23615	COG0305	Participates in initiation and elongation during chromosome replication
C4E05_RS23620	COG0604	alcohol dehydrogenase
C4E05_RS23630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4E05_RS23645	COG0735	belongs to the Fur family
C4E05_RS23650	COG3237	CsbD-like
C4E05_RS23655	COG0534	Mate efflux family protein
C4E05_RS23665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C4E05_RS23700	COG3842	ATPase activity
C4E05_RS23705	COG2182	Extracellular solute-binding protein
C4E05_RS23710	COG1175	transmembrane transport
C4E05_RS23715	COG3833	ABC-type maltose transport systems, permease component
C4E05_RS23720	COG0477	Major facilitator Superfamily
C4E05_RS23720	COG2814	Major facilitator Superfamily
C4E05_RS23735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4E05_RS23760	COG0527	aspartate kinase activity
C4E05_RS23770	COG1187	pseudouridine synthase activity
C4E05_RS23780	COG1283	sodium-dependent phosphate transmembrane transporter activity
C4E05_RS23785	COG1410	methionine synthase
C4E05_RS23785	COG0646	methionine synthase
C4E05_RS23790	COG1414	Transcriptional regulator
C4E05_RS23805	COG2224	Isocitrate lyase
C4E05_RS23810	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C4E05_RS23820	COG0456	acetyltransferase
C4E05_RS23855	COG0151	Belongs to the GarS family
C4E05_RS23860	COG2204	response regulator
C4E05_RS23865	COG4191	Histidine kinase
C4E05_RS23870	COG3678	ATP-independent chaperone mediated protein folding
C4E05_RS23885	COG3068	Protein conserved in bacteria
C4E05_RS23920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C4E05_RS23925	COG2104	thiamine diphosphate biosynthetic process
C4E05_RS23935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4E05_RS23975	COG0250	Participates in transcription elongation, termination and antitermination
C4E05_RS23980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4E05_RS24015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C4E05_RS24015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C4E05_RS24020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4E05_RS24055	COG4206	TonB-dependent receptor
C4E05_RS24070	COG1309	transcriptional regulator
C4E05_RS24080	COG0583	DNA-binding transcription factor activity
C4E05_RS24095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4E05_RS24110	COG2194	sulfuric ester hydrolase activity
C4E05_RS24115	COG2207	Transcriptional regulator
C4E05_RS24120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS24125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C4E05_RS24130	COG1882	Formate acetyltransferase
C4E05_RS24135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS24140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS24145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS24145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4E05_RS24145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS24150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4E05_RS24155	COG0371	Dehydrogenase
C4E05_RS24160	COG3738	Protein conserved in bacteria
C4E05_RS24165	COG0697	spore germination
C4E05_RS24175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4E05_RS24180	COG0527	aspartate kinase activity
C4E05_RS24180	COG0460	homoserine dehydrogenase
C4E05_RS24185	COG0626	cystathionine gamma-synthase activity
C4E05_RS24195	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C4E05_RS24205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4E05_RS24210	COG1609	Transcriptional regulator
C4E05_RS24215	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4E05_RS24230	COG1575	Belongs to the MenA family. Type 1 subfamily
C4E05_RS24245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C4E05_RS24255	COG1494	fructose-1,6-bisphosphatase
C4E05_RS24260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4E05_RS24265	COG0589	response to stress
C4E05_RS24270	COG3691	Protein conserved in bacteria
C4E05_RS24275	COG3152	Membrane
C4E05_RS24295	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4E05_RS24360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C4E05_RS24365	COG4372	Transposase
C4E05_RS24370	COG3436	PFAM IS66 Orf2 family protein
C4E05_RS24390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C4E05_RS24490	COG4695	Portal protein
C4E05_RS24510	COG1484	DNA-dependent DNA replication
C4E05_RS24515	COG4584	PFAM Integrase catalytic
C4E05_RS24560	COG4974	Belongs to the 'phage' integrase family
C4E05_RS24565	COG3678	ATP-independent chaperone mediated protein folding
C4E05_RS24570	COG0745	RESPONSE REGULATOR receiver
C4E05_RS24575	COG2205	protein histidine kinase activity
C4E05_RS24580	COG2258	MOSC domain
C4E05_RS24590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4E05_RS24630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS24635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS24635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4E05_RS24640	COG1363	Peptidase, m42
C4E05_RS24645	COG3711	transcriptional antiterminator
C4E05_RS24645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4E05_RS24665	COG0437	4 iron, 4 sulfur cluster binding
C4E05_RS24670	COG2864	formate dehydrogenase
C4E05_RS24680	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4E05_RS24685	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4E05_RS24690	COG0456	acetyltransferase
C4E05_RS24705	COG1011	Hydrolase
C4E05_RS24710	COG1349	DNA-binding transcription factor activity
C4E05_RS24715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS24720	COG2084	Dehydrogenase
C4E05_RS24725	COG3684	Belongs to the aldolase LacD family
C4E05_RS24730	COG2942	2-epimerase
C4E05_RS24735	COG2017	converts alpha-aldose to the beta-anomer
C4E05_RS24740	COG1501	Belongs to the glycosyl hydrolase 31 family
C4E05_RS24745	COG2211	Major facilitator Superfamily
C4E05_RS24750	COG2211	Major facilitator Superfamily
C4E05_RS24755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4E05_RS24760	COG2271	Major facilitator Superfamily
C4E05_RS24765	COG1082	Xylose isomerase domain protein TIM barrel
C4E05_RS24770	COG2188	Transcriptional regulator
C4E05_RS24775	COG1217	gtp-binding protein TYPA
C4E05_RS24780	COG0174	glutamine synthetase
C4E05_RS24785	COG3852	Histidine kinase
C4E05_RS24790	COG2204	response regulator
C4E05_RS24800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4E05_RS24815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4E05_RS24815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4E05_RS24825	COG0204	Acyl-transferase
C4E05_RS24830	COG5339	Protein conserved in bacteria
C4E05_RS24835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4E05_RS24840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4E05_RS24845	COG3084	Protein conserved in bacteria
C4E05_RS24850	COG0746	molybdenum cofactor guanylyltransferase activity
C4E05_RS24855	COG1763	Mo-molybdopterin cofactor biosynthetic process
C4E05_RS24890	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C4E05_RS24895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4E05_RS24900	COG1739	Uncharacterized protein family UPF0029
C4E05_RS24915	COG0183	Belongs to the thiolase family
C4E05_RS24920	COG0543	2 iron, 2 sulfur cluster binding
C4E05_RS24925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C4E05_RS24930	COG0250	Participates in transcription elongation, termination and antitermination
C4E05_RS24935	COG0084	hydrolase, TatD family'
C4E05_RS24940	COG0805	protein transport
C4E05_RS24945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4E05_RS24950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4E05_RS24960	COG3165	ubiquinone biosynthetic process from chorismate
C4E05_RS24970	COG1322	Protein conserved in bacteria
C4E05_RS24975	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C4E05_RS24980	COG0412	Dienelactone hydrolase
C4E05_RS24990	COG0583	DNA-binding transcription factor activity
C4E05_RS24995	COG0697	spore germination
C4E05_RS25000	COG0561	phosphatase activity
C4E05_RS25005	COG2267	carboxylic ester hydrolase activity
C4E05_RS25010	COG1280	lysine exporter protein (LysE YggA)
C4E05_RS25015	COG1280	lysine exporter protein (LysE YggA)
C4E05_RS25020	COG0514	ATP-dependent DNA helicase (RecQ)
C4E05_RS25025	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C4E05_RS25030	COG2050	protein possibly involved in aromatic compounds catabolism
C4E05_RS25035	COG2962	Rard protein
C4E05_RS25050	COG0598	Magnesium transport protein CorA
C4E05_RS25055	COG3698	Phosphodiester glycosidase
C4E05_RS25060	COG0210	DNA helicase
C4E05_RS25065	COG1011	Hydrolase
C4E05_RS25075	COG3159	Protein conserved in bacteria
C4E05_RS25085	COG5567	small periplasmic lipoprotein
C4E05_RS25100	COG3072	Adenylate cyclase
C4E05_RS25110	COG1587	Uroporphyrinogen-III synthase
C4E05_RS25115	COG2959	enzyme of heme biosynthesis
C4E05_RS25120	COG3071	HemY protein
C4E05_RS25125	COG3119	arylsulfatase activity
C4E05_RS25130	COG0641	radical SAM
C4E05_RS25155	COG1113	amino acid transport
C4E05_RS25175	COG2244	polysaccharide biosynthetic process
C4E05_RS25180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4E05_RS25185	COG0456	acetyltransferase
C4E05_RS25190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C4E05_RS25195	COG1088	dTDP-glucose 4,6-dehydratase activity
C4E05_RS25200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4E05_RS25205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4E05_RS25210	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C4E05_RS25215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4E05_RS25220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4E05_RS25230	COG3118	belongs to the thioredoxin family
C4E05_RS25245	COG0210	DNA helicase
C4E05_RS25255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4E05_RS25265	COG0583	DNA-binding transcription factor activity
C4E05_RS25270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4E05_RS25280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4E05_RS25285	COG3978	acetolactate synthase activity
C4E05_RS25305	COG0606	chelatase, subunit chli
C4E05_RS25310	COG3085	chromosome segregation
C4E05_RS25350	COG2186	Transcriptional regulator
C4E05_RS25355	COG0477	Major facilitator Superfamily
C4E05_RS25360	COG1609	Transcriptional regulator
C4E05_RS25365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4E05_RS25370	COG1879	ABC-type sugar transport system periplasmic component
C4E05_RS25375	COG1172	Belongs to the binding-protein-dependent transport system permease family
C4E05_RS25380	COG1129	ABC transporter
C4E05_RS25410	COG1522	sequence-specific DNA binding
C4E05_RS25415	COG0716	FMN binding
C4E05_RS25430	COG3312	ion transport
C4E05_RS25480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4E05_RS25485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4E05_RS25490	COG0573	inorganic phosphate transmembrane transporter activity
C4E05_RS25495	COG0581	inorganic phosphate transmembrane transporter activity
C4E05_RS25500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4E05_RS25505	COG0704	Plays a role in the regulation of phosphate uptake
C4E05_RS25510	COG3711	transcriptional antiterminator
C4E05_RS25515	COG1263	PTS System
C4E05_RS25515	COG2190	(PTS) system
C4E05_RS25515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C4E05_RS25520	COG2723	6-phospho-beta-galactosidase activity
C4E05_RS25530	COG2382	esterase
C4E05_RS25535	COG0363	glucosamine-6-phosphate deaminase activity
C4E05_RS25540	COG3196	Protein conserved in bacteria
C4E05_RS25550	COG3436	PFAM IS66 Orf2 family protein
C4E05_RS25555	COG4372	Transposase
C4E05_RS25570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4E05_RS25575	COG2252	PERMEase
C4E05_RS25580	COG0431	NADPH-dependent FMN reductase
C4E05_RS25585	COG2091	lysine biosynthetic process via aminoadipic acid
C4E05_RS25600	COG0814	amino acid