locus-tag class description HXS64_RS00025 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HXS64_RS00030 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HXS64_RS00040 ENOG4108Y73 Membrane HXS64_RS00045 ENOG4105EJ2 Transcriptional regulator HXS64_RS00055 ENOG4105C5Q Transcriptional regulator HXS64_RS00070 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HXS64_RS00075 ENOG4105CWC Acetylornithine deacetylase HXS64_RS00080 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HXS64_RS00085 ENOG4105DIJ Phosphoethanolamine transferase HXS64_RS00090 ENOG4106R3P AraC family transcriptional regulator HXS64_RS00095 ENOG4108XCZ PTS System HXS64_RS00100 ENOG4108AHH pyruvate formate lyase II activase HXS64_RS00110 ENOG4108YRF PTS System HXS64_RS00115 ENOG4105DM4 PTS System HXS64_RS00120 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HXS64_RS00125 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HXS64_RS00130 ENOG4105DCT glycerol dehydrogenase HXS64_RS00135 ENOG4108XC3 NADH ubiquinone oxidoreductase HXS64_RS00140 ENOG4108Q5Y Membrane HXS64_RS00150 ENOG4105SYT Methylenetetrahydrofolate reductase HXS64_RS00155 ENOG4105CFH Aspartokinase HXS64_RS00160 ENOG4105C28 cystathionine HXS64_RS00170 ENOG4107S01 Repressor protein MetJ HXS64_RS00180 ENOG4105C25 Primosomal protein n' HXS64_RS00185 ENOG4105ETE Transcriptional regulator (LacI family HXS64_RS00190 ENOG41063M6 Cell Division Protein HXS64_RS00205 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HXS64_RS00220 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HXS64_RS00230 ENOG4105CBT Fructose-1,6-bisphosphatase HXS64_RS00235 ENOG4105DP0 ferredoxin-NADP reductase HXS64_RS00245 ENOG41065TG regulatoR HXS64_RS00250 ENOG4108VTS Membrane HXS64_RS00255 ENOG4105EBK exported protein HXS64_RS00265 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HXS64_RS00270 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HXS64_RS00285 ENOG4105FMW periplasmic HXS64_RS00290 ENOG4105E3W Two component transcriptional regulator (Winged helix family HXS64_RS00295 ENOG4105E0F Histidine kinase HXS64_RS00300 ENOG4108RPX mosc domain containing protein HXS64_RS00310 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HXS64_RS00315 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HXS64_RS00330 ENOG4105DET Rhamnulokinase HXS64_RS00335 ENOG4105DKG l-rhamnose isomerase HXS64_RS00350 ENOG41064BA PTS system, fructose-specific, IIA component HXS64_RS00355 ENOG4105DM4 PTS System HXS64_RS00360 ENOG4105CN9 Peptidase m42 family protein HXS64_RS00365 ENOG4106C3V frv operon regulatory protein HXS64_RS00370 ENOG4108V87 frv operon regulatory protein HXS64_RS00375 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HXS64_RS00385 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HXS64_RS00390 ENOG4108MG3 formate dehydrogenase HXS64_RS00400 ENOG41068KX affects formate dehydrogenase-N HXS64_RS00410 ENOG4105SUU thioesterase domain HXS64_RS00425 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HXS64_RS00430 ENOG4105E98 transcriptional regulator DeoR family HXS64_RS00435 ENOG4108MGF sugar kinase HXS64_RS00440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HXS64_RS00450 ENOG4107QKS N-acylglucosamine 2-epimerase HXS64_RS00455 ENOG4107WI4 Aldose-1-epimerase HXS64_RS00465 ENOG4105CJQ hydrolase, family 31 HXS64_RS00470 ENOG4105CT4 transporter HXS64_RS00475 ENOG4105CT4 transporter HXS64_RS00480 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HXS64_RS00485 ENOG4105R9B Major Facilitator HXS64_RS00490 ENOG4108KHF Resistance protein HXS64_RS00495 ENOG4108K85 Transcriptional regulator HXS64_RS00500 ENOG4105CI3 gtp-binding protein typa HXS64_RS00505 ENOG4105C5F glutamine synthetase HXS64_RS00510 ENOG4105CUX Signal transduction histidine kinase HXS64_RS00515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HXS64_RS00520 ENOG4106FIY HXS64_RS00525 ENOG4105D4P Coproporphyrinogen iii oxidase HXS64_RS00530 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HXS64_RS00540 ENOG4105C2M dna polymerase I HXS64_RS00545 ENOG4106HNH Acyl-transferase HXS64_RS00555 ENOG4108Z33 Thiol disulfide Interchange Protein HXS64_RS00560 ENOG4105E27 serine threonine protein kinase HXS64_RS00565 ENOG4105PC1 Conserved Protein HXS64_RS00570 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HXS64_RS00575 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HXS64_RS00605 ENOG4108RR8 protoporphyrinogen oxidase HXS64_RS00610 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HXS64_RS00615 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HXS64_RS00630 ENOG4105CHU acetyl-coa acetyltransferase HXS64_RS00635 ENOG4108EX3 reductase HXS64_RS00640 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HXS64_RS00645 ENOG4105MDZ Transcriptional activator rfaH HXS64_RS00650 ENOG4105F8V Hydrolase, tatD family HXS64_RS00655 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HXS64_RS00660 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HXS64_RS00665 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HXS64_RS00675 ENOG4105JC1 sterol-binding domain protein HXS64_RS00685 ENOG4105CGY Dna recombination protein HXS64_RS00690 ENOG4108I5U Uridine phosphorylase HXS64_RS00695 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HXS64_RS00700 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HXS64_RS00705 ENOG4105DZ2 Transcriptional regulator HXS64_RS00710 ENOG4105EMK carboxylate amino acid amine transporter HXS64_RS00715 ENOG4105DQF Hydrolase HXS64_RS00720 ENOG4108EUD Lysophospholipase HXS64_RS00725 ENOG410829K Lysine exporter protein (Lyse ygga) HXS64_RS00730 ENOG4105CCF Lysine exporter protein (Lyse ygga) HXS64_RS00735 ENOG4105C9U ATP-dependent DNA helicase RecQ HXS64_RS00740 ENOG4105HDD phospholipase HXS64_RS00745 ENOG4108VUY thioesterase Superfamily protein HXS64_RS00750 ENOG4105FR1 rard protein HXS64_RS00755 ENOG4106WR8 Inner membrane protein YigG HXS64_RS00760 ENOG4105NRM Membrane HXS64_RS00765 ENOG4107QUT magnesium and cobalt transport protein CorA HXS64_RS00770 ENOG4108T58 Mg2 transport protein CorA HXS64_RS00775 ENOG4105C4R Atp-dependent dna helicase HXS64_RS00780 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HXS64_RS00790 ENOG4105CT0 Protein of unknown function, DUF484 HXS64_RS00800 ENOG4105S7Z (LipO)protein HXS64_RS00810 ENOG4107T0K Adenylate cyclase HXS64_RS00815 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HXS64_RS00820 ENOG41076E6 Uroporphyrinogen-III Synthase HXS64_RS00825 ENOG4105ECF c-methyltransferase HXS64_RS00830 ENOG410601J HemY protein HXS64_RS00835 ENOG4105ENH Sulfatase HXS64_RS00840 ENOG4105C4X radical SAM domain protein HXS64_RS00865 ENOG4105C85 amino acid HXS64_RS00870 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HXS64_RS00875 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HXS64_RS00880 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HXS64_RS00885 ENOG4105EGZ biosynthesis protein HXS64_RS00890 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HXS64_RS00895 ENOG4108WJ1 acetyltransferase HXS64_RS00900 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HXS64_RS00905 ENOG4105C1B dTDP-glucose 4-6-dehydratase HXS64_RS00910 ENOG4107QQG Dehydrogenase HXS64_RS00915 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HXS64_RS00920 ENOG4105SFE lipopolysaccharide biosynthesis protein HXS64_RS00925 ENOG4105ESV Glycosyl transferase, family 4 HXS64_RS00930 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HXS64_RS00955 ENOG4105C4R Atp-dependent dna helicase HXS64_RS00965 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HXS64_RS00975 ENOG4105EMY transcriptional regulator HXS64_RS00980 ENOG4105C7B Threonine dehydratase HXS64_RS00990 ENOG4105CM2 brancheD-chain amino acid aminotransferase HXS64_RS00995 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HXS64_RS01015 ENOG4105C0P Mg chelatase subunit ChlI HXS64_RS01020 ENOG4108WFC UPF0438 protein yifE HXS64_RS01060 ENOG4107EJG GntR family transcriptional regulator HXS64_RS01065 ENOG4105C0R drug resistance transporter emrb qaca subfamily HXS64_RS01070 ENOG4105ETE Transcriptional regulator (LacI family HXS64_RS01075 ENOG4108RVA ribokinase HXS64_RS01080 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HXS64_RS01085 ENOG4105CNN ABC, transporter HXS64_RS01090 ENOG4105C2J ABC transporter HXS64_RS01095 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HXS64_RS01110 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HXS64_RS01120 ENOG4108VVK transcriptional Regulator, AsnC HXS64_RS01125 ENOG4105QTB Flavodoxin HXS64_RS01140 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HXS64_RS01190 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HXS64_RS01195 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HXS64_RS01200 ENOG4105C8U phosphate abc transporter HXS64_RS01205 ENOG4105E2Z phosphate ABC transporter (Permease HXS64_RS01210 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HXS64_RS01215 ENOG4108UTW Plays a role in the regulation of phosphate uptake HXS64_RS01220 ENOG4105CID antiterminator HXS64_RS01225 ENOG4105C5Y PTS System HXS64_RS01230 ENOG4105CS2 ec 3.2.1.21 HXS64_RS01240 ENOG4105DYC esterase HXS64_RS01245 ENOG4107VKM 6-phosphogluconolactonase HXS64_RS01260 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HXS64_RS01265 ENOG4105C7N Xanthine uracil vitamin C permease HXS64_RS01270 ENOG4108YYH Nadph-dependent fmn reductase HXS64_RS01275 ENOG4105E8Q phosphopantetheinyl transferase HXS64_RS01280 ENOG4105G2Y Transcriptional regulator HXS64_RS01285 ENOG4105CNH Multidrug resistance protein MdtL HXS64_RS01290 ENOG4108P6C Tryptophan transporter of low affinity HXS64_RS01305 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HXS64_RS01310 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HXS64_RS01325 ENOG4105VG0 50S ribosomal protein l34 HXS64_RS01340 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HXS64_RS01350 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HXS64_RS01355 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HXS64_RS01360 ENOG410667J hydrolase HXS64_RS01365 ENOG410657R replicase EC 2.7 HXS64_RS01370 ENOG4105EMF GntR family transcriptional regulator HXS64_RS01375 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HXS64_RS01380 ENOG4108RTU Aldolase HXS64_RS01390 ENOG4105DJB Major Facilitator Superfamily HXS64_RS01395 ENOG4107WAP fad NAD(P)-binding domain HXS64_RS01400 ENOG4105D99 atp gtp-binding protein HXS64_RS01405 ENOG4105R2A (LipO)protein HXS64_RS01425 ENOG4105FDP GntR family transcriptional regulator HXS64_RS01430 ENOG4105CI1 PTS System HXS64_RS01435 ENOG4105F8D glycoside hydrolase family 4 HXS64_RS01445 ENOG4105D7V transposase HXS64_RS01450 ENOG4105VG5 Membrane HXS64_RS01455 ENOG4105JP4 Inner membrane protein yidG HXS64_RS01460 ENOG4105J13 transcriptional regulator HXS64_RS01465 ENOG4105E5M Multidrug resistance protein D HXS64_RS01480 ENOG4105C7K acetolactate synthase HXS64_RS01485 ENOG4105M71 acetolactate synthase 1 regulatory subunit HXS64_RS01490 ENOG4108KX4 response regulator HXS64_RS01495 ENOG4105BZU Histidine kinase HXS64_RS01500 ENOG4105CXY transporter HXS64_RS01505 ENOG4105CXY transporter HXS64_RS01510 ENOG4105CPN adenine deaminase HXS64_RS01515 ENOG4105C7N Xanthine uracil vitamin C permease HXS64_RS01520 ENOG4108SAJ Protein of unknown function (DUF1198) HXS64_RS01530 ENOG4105T8A Uncharacterized protein YicS HXS64_RS01535 ENOG4105D01 (LipO)protein HXS64_RS01540 ENOG4108UZ3 Transporter HXS64_RS01545 ENOG4105S8Q sugar efflux transporter HXS64_RS01560 ENOG4105CT4 transporter HXS64_RS01565 ENOG4105CJQ hydrolase, family 31 HXS64_RS01570 ENOG4105JV1 AsmA family HXS64_RS01575 ENOG4105C2W permease HXS64_RS01580 ENOG4105D6U Sodium Glutamate Symporter HXS64_RS01585 ENOG4105CB5 ATP-dependent DNA helicase recG HXS64_RS01590 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HXS64_RS01595 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HXS64_RS01605 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HXS64_RS01610 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HXS64_RS01615 ENOG4105EN6 Membrane HXS64_RS01620 ENOG4105F5P DNA-damage-inducible protein d HXS64_RS01630 ENOG4105DSJ YicC domain protein HXS64_RS01650 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HXS64_RS01655 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HXS64_RS01665 ENOG4105KDC 50s ribosomal protein l28 HXS64_RS01685 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HXS64_RS01690 ENOG4105DKP glycosyl transferase, family 9 HXS64_RS01695 ENOG4107RJ7 Glycosyl transferase (Group 1 HXS64_RS01700 ENOG4107543 (lipo)polysaccharide HXS64_RS01705 ENOG4106AH0 Glycosyl Transferase HXS64_RS01710 ENOG4105X1N Glycosyl transferase family 8 HXS64_RS01720 ENOG4105X1N Glycosyl transferase family 8 HXS64_RS01725 ENOG4105K64 Glycosyl transferase, family 2 HXS64_RS01730 ENOG41068PG O-Antigen polymerase HXS64_RS01735 ENOG4105D16 lipopolysaccharide heptosyltransferase i HXS64_RS01740 ENOG4105XA0 heptosyltransferase ii HXS64_RS01750 ENOG4108SEH involved in lipopolysaccharide biosynthesis HXS64_RS01755 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HXS64_RS01760 ENOG4105CPQ Dehydrogenase HXS64_RS01765 ENOG4105K64 Glycosyl transferase, family 2 HXS64_RS01770 ENOG4105PXI polysaccharide deacetylase HXS64_RS01775 ENOG41063SB peptidase HXS64_RS01780 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HXS64_RS01785 ENOG4107YZP Rhodanese domain protein HXS64_RS01790 ENOG4105VW4 glutaredoxin 3 HXS64_RS01805 ENOG4105D7W serine acetyltransferase HXS64_RS01810 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HXS64_RS01820 ENOG41073TP transcriptional regulator HXS64_RS01825 ENOG4105DAA L-lactate HXS64_RS01830 ENOG4108YYI Protein of unknown function (DUF2810) HXS64_RS01840 ENOG4105E61 Mannitol repressor protein HXS64_RS01850 ENOG4105CTS PTS system mannitol-specific HXS64_RS01855 ENOG4105FP6 Protein of unknown function (DUF3302) HXS64_RS01860 ENOG4105EFX secretion protein, HlyD family HXS64_RS01880 ENOG4108U78 Glutathione S-transferase HXS64_RS01890 ENOG4105EM7 Selenocysteine-specific translation elongation factor HXS64_RS01895 ENOG4105C0A alcohol dehydrogenase HXS64_RS01900 ENOG4105C26 Dehydrogenase HXS64_RS01910 ENOG4105KK7 inner membrane protein YiaW HXS64_RS01915 ENOG4105EFX secretion protein, HlyD family HXS64_RS01920 ENOG4108Q2M Transcriptional regulator HXS64_RS01925 ENOG4105GNX MltA-interacting MipA family protein HXS64_RS01935 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HXS64_RS01940 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HXS64_RS01945 ENOG4105H6Q decarboxylase HXS64_RS01950 ENOG4105CMG Carbohydrate kinase HXS64_RS01955 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HXS64_RS01960 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HXS64_RS01965 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HXS64_RS01970 ENOG4108R66 Conserved Protein HXS64_RS01980 ENOG4105J4Q Transcriptional regulator HXS64_RS01985 ENOG4108XIB electron transport protein ysaA HXS64_RS01990 ENOG4105JKW Valine--pyruvate aminotransferase HXS64_RS01995 ENOG4107T9C Alpha amylase catalytic region HXS64_RS02000 ENOG4108UR8 BAX protein HXS64_RS02005 ENOG4105T16 Transcriptional regulator (AraC family) HXS64_RS02010 ENOG4108HWW ABC transporter HXS64_RS02015 ENOG4105C2J ABC transporter HXS64_RS02020 ENOG4105DFW ABC transporter HXS64_RS02030 ENOG4105CMG Carbohydrate kinase HXS64_RS02035 ENOG410688U Inner membrane protein yiaB HXS64_RS02050 ENOG4108Z12 YiaAB two helix domain-containing protein HXS64_RS02055 ENOG4105MEV Acyl-transferase HXS64_RS02060 ENOG4105RGS lipoprotein ysaB HXS64_RS02095 ENOG41060TC Hok gef cell toxic protein HXS64_RS02105 ENOG4105MVF Transcriptional regulator HXS64_RS02110 ENOG4106JH6 (LipO)protein HXS64_RS02115 ENOG4105C5I Dehydrogenase HXS64_RS02120 ENOG4108ZG0 Ompa motb domain protein HXS64_RS02125 ENOG4107QY8 reductase HXS64_RS02130 ENOG4105HNP -acetyltransferase HXS64_RS02135 ENOG4108R3E Dna-3-methyladenine glycosylase i HXS64_RS02140 ENOG4105EAX Putative lipase HXS64_RS02145 ENOG4105FCD Major Facilitator HXS64_RS02150 ENOG4105DIJ Phosphoethanolamine transferase HXS64_RS02165 ENOG4105DEF Extracellular solute-binding protein, family 5 HXS64_RS02170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HXS64_RS02175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HXS64_RS02180 ENOG4105C3U ABC transporter HXS64_RS02185 ENOG4108JQ7 (ABC) transporter HXS64_RS02190 ENOG4105C44 Serine transporter HXS64_RS02200 ENOG4105D1V cellulose synthase operon protein YhjU HXS64_RS02205 ENOG4105WQA Cellulose biosynthesis protein BcsF HXS64_RS02210 ENOG4105U74 cellulose biosynthesis protein BcsE HXS64_RS02215 ENOG410661M cytoplasmic protein HXS64_RS02225 ENOG4107QZ7 Cellulose synthase catalytic subunit HXS64_RS02230 ENOG4107EEX Cellulose synthase regulator protein HXS64_RS02235 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HXS64_RS02240 ENOG4105EJG cellulose synthase HXS64_RS02245 ENOG4105BZU Histidine kinase HXS64_RS02255 ENOG4105CS0 peptidase HXS64_RS02260 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HXS64_RS02265 ENOG4105CMB EAL domain-containing protein HXS64_RS02270 ENOG41066T0 asmA family HXS64_RS02275 ENOG4105CSH Transporter HXS64_RS02280 ENOG4107H3J ribonuclease HXS64_RS02285 ENOG4105CBN LysR family transcriptional regulator HXS64_RS02290 ENOG4106S2D Transcriptional regulator HXS64_RS02300 ENOG4105CA0 peroxidase HXS64_RS02305 ENOG4105CVK Glutamate decarboxylase HXS64_RS02310 ENOG4108NKV transcriptional regulator HXS64_RS02320 ENOG4105BZS acriflavin resistance protein HXS64_RS02325 ENOG4105C1P efflux transporter, rnd family, mfp subunit HXS64_RS02335 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HXS64_RS02340 ENOG4108YK4 Acid-resistance membrane protein HXS64_RS02345 ENOG41060V2 Acid-resistance protein HXS64_RS02350 ENOG4105XXV Acid-resistance protein HXS64_RS02355 ENOG4105KT7 mgtC SapB transporter HXS64_RS02365 ENOG4105Y4Z Outer Membrane Lipoprotein HXS64_RS02375 ENOG4105K89 arsenate reductase HXS64_RS02380 ENOG4107R5R arsenical pump membrane protein HXS64_RS02385 ENOG4105KBH arsR family transcriptional regulator HXS64_RS02395 ENOG4105DC8 reductase HXS64_RS02400 ENOG4105D6S protein involved in catabolism of external DNA HXS64_RS02405 ENOG4105DGW oligopeptidase A HXS64_RS02415 ENOG4105DUX Transporter HXS64_RS02430 ENOG4105CJ3 phosphate transporter HXS64_RS02435 ENOG4105CBX hi0933 family HXS64_RS02440 ENOG4107UNS conserved inner membrane protein HXS64_RS02455 ENOG4105D0S secretion protein (HlyD HXS64_RS02460 ENOG4105CJ1 ABC, transporter HXS64_RS02465 ENOG4105CMI transporter HXS64_RS02470 ENOG410600T transposase HXS64_RS02475 ENOG4105NUP lyase containing HEAT-repeat HXS64_RS02485 ENOG4105CNA YD repeat protein HXS64_RS02495 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HXS64_RS02500 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HXS64_RS02505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HXS64_RS02510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HXS64_RS02515 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HXS64_RS02520 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HXS64_RS02525 ENOG4105DSF transport protein HXS64_RS02530 ENOG4105F9N Major Facilitator Superfamily HXS64_RS02535 ENOG4108W1V Lipoprotein HXS64_RS02540 ENOG4105EX9 Membrane HXS64_RS02550 ENOG4105C59 p-type ATPase HXS64_RS02555 ENOG4107FS9 Membrane HXS64_RS02565 ENOG4105MG3 Membrane HXS64_RS02570 ENOG4106H78 methyltransferase HXS64_RS02575 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HXS64_RS02580 ENOG4105CAK Cell division ATP-binding protein ftsE HXS64_RS02585 ENOG4105CRP Part of the ABC transporter FtsEX involved in HXS64_RS02590 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HXS64_RS02595 ENOG4105CP9 extracellular ligand-binding receptor HXS64_RS02600 ENOG4105U59 -acetyltransferase HXS64_RS02605 ENOG4105CP9 extracellular ligand-binding receptor HXS64_RS02610 ENOG4105C32 Amino acid ABC transporter (Permease) HXS64_RS02615 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HXS64_RS02620 ENOG4105C0Z ABC transporter HXS64_RS02625 ENOG4108IV0 ABC, transporter HXS64_RS02630 ENOG4105BZ7 extracellular solute-binding protein family 1 HXS64_RS02635 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HXS64_RS02640 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HXS64_RS02645 ENOG4108IJ9 (ABC) transporter HXS64_RS02650 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HXS64_RS02655 ENOG4105WC8 Conserved Protein HXS64_RS02660 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HXS64_RS02665 ENOG4106FA4 HXS64_RS02680 ENOG4105GMB type VI secretion system effector, hcp1 family HXS64_RS02685 ENOG4105WCN acetyltransferase HXS64_RS02690 ENOG4105D9R oxidoreductase HXS64_RS02695 ENOG4105C2I pirin domain protein HXS64_RS02700 ENOG4105DIQ Transcriptional regulator HXS64_RS02705 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HXS64_RS02710 ENOG4105C6Z Gluconate HXS64_RS02715 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HXS64_RS02720 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HXS64_RS02730 ENOG4108IUM Glycogen debranching enzyme HXS64_RS02745 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HXS64_RS02755 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HXS64_RS02770 ENOG4105E98 transcriptional regulator DeoR family HXS64_RS02775 ENOG4105CYB regulatoR HXS64_RS02780 ENOG4105E0Y RtcB Protein HXS64_RS02785 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HXS64_RS02795 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HXS64_RS02800 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HXS64_RS02805 ENOG4105C6Z Gluconate HXS64_RS02815 ENOG4105MJ2 Competence protein HXS64_RS02820 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HXS64_RS02825 ENOG4105DNE Transposase HXS64_RS02835 ENOG4105CE1 Ferrous iron transport protein b HXS64_RS02840 ENOG4105XFK Ferrous iron transport protein A HXS64_RS02845 ENOG4105BZM domain protein HXS64_RS02850 ENOG4108RRZ Transcription elongation factor GreB HXS64_RS02860 ENOG4105E0F Histidine kinase HXS64_RS02870 ENOG4108MAJ Membrane HXS64_RS02880 ENOG4105VEJ Heat shock protein HXS64_RS02885 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HXS64_RS02890 ENOG4105DQY intracellular growth attenuator HXS64_RS02895 ENOG4107RK2 ADP-ribose diphosphatase NudE HXS64_RS02900 ENOG4108JQC penicillin-binding protein 1A HXS64_RS02905 ENOG4108U1Q Pilus assembly protein HXS64_RS02910 ENOG41065NF Fimbrial assembly family protein HXS64_RS02915 ENOG4105XPX DNA utilization protein HofO HXS64_RS02920 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HXS64_RS02925 ENOG4105E4G Type IV pilus HXS64_RS02940 ENOG4105EGB membrane protein DamX HXS64_RS02945 ENOG4105DFE Dna adenine methylase HXS64_RS02950 ENOG4105DJV ribulose-phosphate 3-epimerase HXS64_RS02955 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HXS64_RS02960 ENOG4105C31 Tryptophanyl-tRNA synthetase HXS64_RS02965 ENOG4108M21 HXS64_RS02970 ENOG4105RMW regulation of transcription, DNA-dependent HXS64_RS02975 ENOG4108626 Racemase HXS64_RS02980 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HXS64_RS02985 ENOG41080QX K07048 phosphotriesterase-related protein HXS64_RS02990 ENOG4105MUZ Protein of unknown function DUF2620 HXS64_RS02995 ENOG4106M0N transport system permease protein HXS64_RS03000 ENOG4106PKC pyridoxal phosphate binding HXS64_RS03005 ENOG4105FDP GntR family transcriptional regulator HXS64_RS03010 ENOG4108KPW sugar kinase HXS64_RS03015 ENOG4107Y0V Not clear, may be involved in an isomerization step HXS64_RS03020 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HXS64_RS03025 ENOG4107QHQ amino acid HXS64_RS03030 ENOG4105VYH HXS64_RS03040 ENOG4107V9H nitrite transporter HXS64_RS03045 ENOG4105WZK nitrite reductase NADPH small subunit HXS64_RS03050 ENOG4107QZF nitrite reductase NADPH large subunit HXS64_RS03060 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HXS64_RS03070 ENOG4105MZU cell filamentation protein HXS64_RS03075 ENOG4105DDQ anthranilate synthase HXS64_RS03080 ENOG4105C8Y Acetylornithine aminotransferase HXS64_RS03085 ENOG410613R integral membrane protein, YccS YhfK family HXS64_RS03095 ENOG4108UKZ OsmC family HXS64_RS03100 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HXS64_RS03110 ENOG4105DNZ Alpha Beta Hydrolase HXS64_RS03115 ENOG4105C5H ABC transporter HXS64_RS03125 ENOG4105CKD glutathione-regulated potassium-efflux system protein HXS64_RS03130 ENOG4105VKU nucleicacid-binding protein HXS64_RS03135 ENOG4108YZY peptidylprolyl cis-trans isomerase HXS64_RS03145 ENOG4108V1T peptidylprolyl cis-trans isomerase HXS64_RS03150 ENOG4105WWK YheO domain protein HXS64_RS03155 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HXS64_RS03160 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HXS64_RS03165 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HXS64_RS03190 ENOG4108NNZ chitinase HXS64_RS03195 ENOG4105W53 bacterioferritin-associated ferredoxin HXS64_RS03200 ENOG4108UQY Iron-storage protein HXS64_RS03205 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HXS64_RS03215 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HXS64_RS03220 ENOG4105R04 type II secretion system protein K HXS64_RS03235 ENOG41069X0 general secretion pathway protein h HXS64_RS03240 ENOG4108VAU general secretion pathway protein G HXS64_RS03250 ENOG4107QHF type ii secretion system protein e HXS64_RS03255 ENOG4105GVR general secretion pathway protein D HXS64_RS03260 ENOG4107KSE General secretion pathway protein C HXS64_RS03265 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HXS64_RS03270 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication HXS64_RS03290 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HXS64_RS03335 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HXS64_RS03385 ENOG41067V7 50S ribosomal protein L36 HXS64_RS03415 ENOG4105VTS DnaJ-like, subfamily C HXS64_RS03420 ENOG4105W1Y Transcriptional regulator HXS64_RS03425 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HXS64_RS03435 ENOG4105C1A potassium transporter peripheral membrane HXS64_RS03455 ENOG4105C79 DNA protecting protein DprA HXS64_RS03465 ENOG4108WI1 Dna topoisomerase HXS64_RS03480 ENOG4105SG3 Protein of unknown function (DUF1488) HXS64_RS03485 ENOG4108Z0R Transferase HXS64_RS03525 ENOG4105CDA abc transporter atp-binding protein HXS64_RS03530 ENOG4105DRP amino acid AbC transporter HXS64_RS03535 ENOG4105EZ7 amino acid ABC transporter HXS64_RS03545 ENOG4105XCM membrane LIPOPROTEIN HXS64_RS03555 ENOG4105C1P efflux transporter, rnd family, mfp subunit HXS64_RS03560 ENOG4108XG4 DNA-binding transcriptional regulator HXS64_RS03565 ENOG41061ME transport protein HXS64_RS03580 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HXS64_RS03590 ENOG4108IA2 Sodium pantothenate symporter HXS64_RS03595 ENOG4105RG0 Membrane HXS64_RS03600 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HXS64_RS03605 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HXS64_RS03610 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HXS64_RS03615 ENOG41062P1 Diguanylate cyclase phosphodiesterase HXS64_RS03625 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HXS64_RS03630 ENOG4105VQ7 Rod shape-determining protein MreD HXS64_RS03635 ENOG4108Z03 MAF-like protein HXS64_RS03640 ENOG4105C03 ribonuclease HXS64_RS03645 ENOG4105QD6 exported protein HXS64_RS03650 ENOG4105D1U peptidase U62 modulator of DNA gyrase HXS64_RS03655 ENOG4105CR8 Transcriptional regulator HXS64_RS03660 ENOG4105ZQC membrane protein AaeX HXS64_RS03675 ENOG4105UNR (Barnase) inhibitor HXS64_RS03680 ENOG4105RID UPF0379 protein yhcN HXS64_RS03695 ENOG4105C0H protease HXS64_RS03700 ENOG4105C0H protease HXS64_RS03705 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HXS64_RS03710 ENOG4105D6Z AFG1 family ATPase HXS64_RS03725 ENOG4107MKT Stringent starvation protein a HXS64_RS03730 ENOG4105KB2 stringent starvation protein b HXS64_RS03735 ENOG4105CEE C4-dicarboxylate transporter HXS64_RS03740 ENOG4108QBF Transcriptional regulator HXS64_RS03750 ENOG4105JHE Major Facilitator Superfamily HXS64_RS03760 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HXS64_RS03765 ENOG4108R66 Conserved Protein HXS64_RS03770 ENOG4105DFS Conserved Protein HXS64_RS03780 ENOG4105BZ8 glutamate synthase HXS64_RS03785 ENOG4105CBC glutamate synthase HXS64_RS03790 ENOG4105N5T Radical SAM Protein HXS64_RS03795 ENOG4105BZU Histidine kinase HXS64_RS03800 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HXS64_RS03810 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HXS64_RS03815 ENOG41080Z8 PHOSPHOCARRIER protein HXS64_RS03825 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HXS64_RS03830 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HXS64_RS03835 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HXS64_RS03840 ENOG4108IUZ ABC transporter HXS64_RS03845 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HXS64_RS03850 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HXS64_RS03855 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HXS64_RS03860 ENOG4105C2X Arabinose 5-phosphate isomerase HXS64_RS03865 ENOG4105FEU K -dependent Na -Ca exchanger HXS64_RS03870 ENOG4105DHJ ABC, transporter HXS64_RS03875 ENOG4105CY3 ABC transporter, permease HXS64_RS03880 ENOG4107PE3 Mammalian cell entry related domain protein HXS64_RS03885 ENOG4105E3I toluene tolerance HXS64_RS03890 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HXS64_RS03895 ENOG4105VFK BolA family HXS64_RS03905 ENOG4105HVQ Regulatory factor of maltose metabolism HXS64_RS03910 ENOG4105EAH synthase HXS64_RS03925 ENOG4105QYV Membrane HXS64_RS03935 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HXS64_RS03940 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HXS64_RS03945 ENOG4105HBR Rna-binding protein HXS64_RS03955 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HXS64_RS03960 ENOG4105EEI dihydropteroate synthase HXS64_RS03970 ENOG4105NTZ Preprotein translocase subunit SecG HXS64_RS04010 ENOG4105CHV Transcription elongation factor NusA HXS64_RS04050 ENOG4105C1J atp-dependent rna helicase HXS64_RS04055 ENOG4105CIC tryptophan-specific transport protein HXS64_RS04060 ENOG4105DEN Luciferase family HXS64_RS04080 ENOG4108YYD acetyltransferase HXS64_RS04085 ENOG41082IR Excinuclease ABC C subunit domain protein HXS64_RS04095 ENOG4107R7Y intracellular protease Pfpi family HXS64_RS04100 ENOG4105K4T epimerase HXS64_RS04105 ENOG4107S21 permease HXS64_RS04110 ENOG4105W4M Transport-associated protein HXS64_RS04120 ENOG41082RQ UPF0102 protein HXS64_RS04125 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HXS64_RS04130 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HXS64_RS04135 ENOG4105I74 Fimbrial protein HXS64_RS04155 ENOG4105DJB Major Facilitator Superfamily HXS64_RS04165 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HXS64_RS04170 ENOG4105BZW Glycerate kinase HXS64_RS04195 ENOG410811B TRANSCRIPTIONal HXS64_RS04200 ENOG4105C7B Threonine dehydratase HXS64_RS04210 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HXS64_RS04215 ENOG4105C6N Formate acetyltransferase HXS64_RS04220 ENOG4105KME endoribonuclease L-psp HXS64_RS04225 ENOG4105EJQ L-serine dehydratase HXS64_RS04230 ENOG4105C44 Serine transporter HXS64_RS04235 ENOG4105CEM UPF0597 protein HXS64_RS04240 ENOG4106D80 Uncharacterized protein YhaL HXS64_RS04245 ENOG4108CNN domain protein HXS64_RS04250 ENOG4105CWB LysR family transcriptional Regulator HXS64_RS04255 ENOG4105KAF membrAne HXS64_RS04260 ENOG4105KAF membrAne HXS64_RS04265 ENOG4105CHF Glutathione S-transferase HXS64_RS04270 ENOG4108VBZ doxx family HXS64_RS04275 ENOG4105YJD HXS64_RS04280 ENOG41090KG Inner membrane protein YqjE HXS64_RS04285 ENOG4105NE1 Conserved Protein HXS64_RS04290 ENOG4105WAY exported protein HXS64_RS04295 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HXS64_RS04300 ENOG4106W5V Membrane HXS64_RS04305 ENOG4107YCY Transcriptional regulator HXS64_RS04310 ENOG4105DPW Major facilitator superfamily MFS_1 HXS64_RS04320 ENOG4105CTX dehydratase HXS64_RS04325 ENOG4105P66 Membrane HXS64_RS04330 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HXS64_RS04335 ENOG4105DU1 integral membrane protein, terc HXS64_RS04340 ENOG4105EE0 oxidoreductase HXS64_RS04345 ENOG4108UB4 uncharacterized protein ygjQ HXS64_RS04350 ENOG4108VKG metal-dependent hydrolase HXS64_RS04355 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HXS64_RS04360 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HXS64_RS04365 ENOG4108Z3N Transcriptional regulator HXS64_RS04370 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HXS64_RS04375 ENOG4107WCA isomerase HXS64_RS04380 ENOG4107W6W Conserved Protein HXS64_RS04385 ENOG4105E5D amino acid HXS64_RS04390 ENOG4105FK9 beta-D-galactosidase beta subunit HXS64_RS04395 ENOG4105CNT hydrolase family 2 HXS64_RS04400 ENOG4105CQ4 Transcriptional regulator HXS64_RS04405 ENOG4108Y51 tRNA-binding protein HXS64_RS04410 ENOG4105C8Y Acetylornithine aminotransferase HXS64_RS04415 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HXS64_RS04420 ENOG4105NTW Transcriptional regulator HXS64_RS04425 ENOG4105Q26 Siderophore-interacting protein HXS64_RS04440 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HXS64_RS04445 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HXS64_RS04455 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HXS64_RS04460 ENOG4107QPK )-transporter HXS64_RS04465 ENOG4107GFK fumarate HXS64_RS04470 ENOG4106DSS Tartrate dehydratase subunit alpha HXS64_RS04475 ENOG4105EJC lysr family transcriptional regulator HXS64_RS04485 ENOG4107ZVW dihydroneopterin aldolase HXS64_RS04500 ENOG4106MWK domain protein HXS64_RS04505 ENOG4105I7R Adenylate cyclase HXS64_RS04510 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HXS64_RS04530 ENOG4107S78 Band 7 protein HXS64_RS04535 ENOG4105PV3 Inner membrane protein yqiJ HXS64_RS04545 ENOG4108MY7 Fimbrial HXS64_RS04550 ENOG4108TTM chaperone HXS64_RS04570 ENOG4105H8W Fimbrial protein HXS64_RS04575 ENOG4105W0Z cytoplasmic protein HXS64_RS04595 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HXS64_RS04600 ENOG4106032 Glutathionylspermidine synthase HXS64_RS04610 ENOG4105DFG type I secretion outer membrane protein HXS64_RS04615 ENOG41087AY ADP-Ribose pyrophosphatase HXS64_RS04620 ENOG4108SX3 cytoplasmic protein HXS64_RS04625 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HXS64_RS04630 ENOG4105IPS esterase HXS64_RS04635 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HXS64_RS04640 ENOG4105VRH Antibiotic biosynthesis monooxygenase HXS64_RS04645 ENOG4105NF4 modulator of drug activity HXS64_RS04650 ENOG4107DEU Inner membrane protein YgiZ HXS64_RS04660 ENOG4105DHQ Histidine kinase HXS64_RS04665 ENOG4105XJC Two component transcriptional regulator (Winged helix family HXS64_RS04670 ENOG4105H4F exported protein HXS64_RS04675 ENOG4105F4I Transcriptional regulator HXS64_RS04680 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation HXS64_RS04685 ENOG4105WJ3 XRE family Transcriptional regulator HXS64_RS04690 ENOG4108J59 Extracellular solute-binding protein, family 5 HXS64_RS04695 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HXS64_RS04700 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HXS64_RS04705 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HXS64_RS04710 ENOG4105CCT upf0313 protein HXS64_RS04720 ENOG4105ZKC Conserved Protein HXS64_RS04725 ENOG4105CV8 reductase HXS64_RS04730 ENOG4108I6A alcohol dehydrogenase HXS64_RS04735 ENOG4105CF7 AraC family transcriptional regulator HXS64_RS04740 ENOG4108K81 inner membrane protein YghB HXS64_RS04745 ENOG4105C28 cystathionine HXS64_RS04750 ENOG4105CWK Biopolymer transport protein, ExbB HXS64_RS04755 ENOG4108ZZF transport protein (ExbD) HXS64_RS04760 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HXS64_RS04770 ENOG4105CPC Aldo Keto reductase HXS64_RS04780 ENOG410900S Protein of unknown function (DUF2623) HXS64_RS04785 ENOG4105E3S small subunit HXS64_RS04790 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HXS64_RS04795 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HXS64_RS04800 ENOG4105DPX Hydrogenase, large subunit HXS64_RS04805 ENOG4108USZ hydrogenase HXS64_RS04810 ENOG4108WGS hydrogenase 2-specific chaperone HXS64_RS04820 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HXS64_RS04825 ENOG4105CYM Glutathione S-transferase HXS64_RS04830 ENOG4106032 Glutathionylspermidine synthase HXS64_RS04835 ENOG4105CJ3 phosphate transporter HXS64_RS04840 ENOG4108GH0 ATP-binding protein yghT HXS64_RS04845 ENOG4108NDC ATP-binding protein yghS HXS64_RS04850 ENOG4106FPV ATP-binding protein YghR HXS64_RS04855 ENOG4108S55 polysaccharide biosynthesis protein HXS64_RS04865 ENOG4108UUE Transcriptional regulator HXS64_RS04870 ENOG4108M8S permease YjgP YjgQ family protein HXS64_RS04880 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HXS64_RS04885 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HXS64_RS04905 ENOG4108KWP DNA-binding transcriptional regulator GlcC HXS64_RS04910 ENOG4105CQB FAD linked oxidase domain protein HXS64_RS04915 ENOG4105EU8 FAD linked oxidase domain protein HXS64_RS04920 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HXS64_RS04925 ENOG4108ZJF Glcg protein HXS64_RS04930 ENOG4107QP3 malate synthase g HXS64_RS04935 ENOG4105DAA L-lactate HXS64_RS04940 ENOG4105F88 accessory colonization factor AcfD HXS64_RS04945 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HXS64_RS04950 ENOG410765S (LipO)protein HXS64_RS04965 ENOG4107QHF type ii secretion system protein e HXS64_RS04970 ENOG4105D7Q type ii secretion system HXS64_RS04975 ENOG4108VAU general secretion pathway protein G HXS64_RS04985 ENOG4105X5Z General secretion pathway protein I HXS64_RS05005 ENOG4105U1E general secretion pathway protein M HXS64_RS05015 ENOG4107V1M polysaccharide export protein HXS64_RS05020 ENOG41090SZ ABC-2 type transporter HXS64_RS05055 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HXS64_RS05060 ENOG4105ECY inositol monophosphatase HXS64_RS05090 ENOG4105C1B dTDP-glucose 4-6-dehydratase HXS64_RS05095 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HXS64_RS05105 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HXS64_RS05115 ENOG41084CK capsule polysaccharide HXS64_RS05140 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HXS64_RS05155 ENOG4105MFG Antirestriction protein HXS64_RS05160 ENOG4106H6R UPF0380 protein HXS64_RS05210 ENOG4108UQV Membrane HXS64_RS05215 ENOG4105CXN decarboxylase HXS64_RS05220 ENOG4105EAA nucleoside HXS64_RS05235 ENOG4105CEN a g-specific adenine glycosylase HXS64_RS05245 ENOG41090ED Protein with unknown function (DUF469) HXS64_RS05255 ENOG4105K33 Periplasmic Protein HXS64_RS05260 ENOG4105HDK L-asparaginase HXS64_RS05265 ENOG4106MH3 alpha helix chain HXS64_RS05270 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HXS64_RS05275 ENOG41069H7 transport system small permease component HXS64_RS05280 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HXS64_RS05285 ENOG4105CSA Coproporphyrinogen iii oxidase HXS64_RS05290 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HXS64_RS05300 ENOG4108VIA integral membrane protein HXS64_RS05305 ENOG4105DFA alanine racemase domain protein HXS64_RS05310 ENOG4105CZX twitching motility protein HXS64_RS05325 ENOG4105D7Z glutathione synthase HXS64_RS05330 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HXS64_RS05335 ENOG4105RWS endonuclease I HXS64_RS05345 ENOG4107QNK )-transporter HXS64_RS05350 ENOG4105VNT transposase (IS4 family) protein HXS64_RS05375 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HXS64_RS05385 ENOG4108K0D peptidase, M48 HXS64_RS05390 ENOG4105CV1 Transketolase (EC 2.2.1.1) HXS64_RS05395 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HXS64_RS05400 ENOG4105CTS PTS system mannitol-specific HXS64_RS05405 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HXS64_RS05415 ENOG4108R4K DNA-binding, transcriptional regulator HXS64_RS05420 ENOG4107Z1W Fructose transport system kinase HXS64_RS05435 ENOG4105D2N Aldolase HXS64_RS05440 ENOG4105D64 Mechanosensitive ion channel HXS64_RS05445 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HXS64_RS05450 ENOG4105MPN Membrane HXS64_RS05455 ENOG4105DEQ transcriptional regulator HXS64_RS05460 ENOG4105CYC Transferase HXS64_RS05465 ENOG4108M7F enoyl-CoA hydratase isomerase HXS64_RS05470 ENOG4105DJT lAO AO transport system ATPase HXS64_RS05475 ENOG4105D5P Methylmalonyl-coA mutase HXS64_RS05490 ENOG4108JQ1 Dehydrogenase HXS64_RS05500 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HXS64_RS05520 ENOG4107RAQ aminopeptidase HXS64_RS05525 ENOG4105D0A hydroxylase HXS64_RS05530 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HXS64_RS05555 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HXS64_RS05560 ENOG4105CS2 ec 3.2.1.21 HXS64_RS05565 ENOG4105N5Z UPF0267 protein HXS64_RS05570 ENOG4108UT2 hemolysin iii HXS64_RS05575 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HXS64_RS05580 ENOG4105Y75 tpr repeat protein HXS64_RS05585 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HXS64_RS05590 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HXS64_RS05595 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HXS64_RS05600 ENOG4105T95 Thiol disulfide interChange protein HXS64_RS05605 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HXS64_RS05635 ENOG4105C2W permease HXS64_RS05645 ENOG4108K5P (LipO)protein HXS64_RS05660 ENOG4105ISV protein with bipartite regulator domain HXS64_RS05665 ENOG4108MHD transport protein HXS64_RS05670 ENOG4105CHU acetyl-coa acetyltransferase HXS64_RS05680 ENOG4105CHR reductase HXS64_RS05685 ENOG4107QNK )-transporter HXS64_RS05695 ENOG4105RQF LysR family Transcriptional regulator HXS64_RS05705 ENOG41060NJ transcriptional regulator HXS64_RS05720 ENOG4105CPC Aldo Keto reductase HXS64_RS05725 ENOG4105SUV lipoprotein YgdR HXS64_RS05730 ENOG4105EE5 Membrane protein terC HXS64_RS05745 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HXS64_RS05760 ENOG4105IPU prepilin peptidase dependent protein A HXS64_RS05765 ENOG4105JCS prepilin peptidase dependent protein HXS64_RS05770 ENOG4105SEN Protein of unknown function (DUF2509) HXS64_RS05775 ENOG4105RVB Prepilin peptidase dependent protein c HXS64_RS05780 ENOG4105DSY exodeoxyribonuclease V, gamma HXS64_RS05785 ENOG4107QXK peptidase HXS64_RS05790 ENOG4107QKA exodeoxyribonuclease V beta HXS64_RS05795 ENOG4107QYX exodeoxyribonuclease v alpha HXS64_RS05800 ENOG4108EKC n-acetylglutamate synthase HXS64_RS05805 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HXS64_RS05825 ENOG4105CA3 membrane-bound lytic murein transglycosylase HXS64_RS05830 ENOG4105CUZ uba thif-type nad fad binding protein HXS64_RS05835 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HXS64_RS05840 ENOG4105C9B Cysteine desulfurase HXS64_RS05845 ENOG4105M5B (LipO)protein HXS64_RS05850 ENOG4105ETT transcriptional Regulator, LysR family HXS64_RS05855 ENOG4105M08 Membrane HXS64_RS05865 ENOG4107EDW L-fucose operon activator HXS64_RS05875 ENOG4105CMG Carbohydrate kinase HXS64_RS05880 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HXS64_RS05885 ENOG4105EDR glucose galactose transporter HXS64_RS05890 ENOG4107W7X Aldolase HXS64_RS05895 ENOG4105C0A alcohol dehydrogenase HXS64_RS05905 ENOG4105EJQ L-serine dehydratase HXS64_RS05910 ENOG4105C44 Serine transporter HXS64_RS05915 ENOG4105EWT decarboxylase family HXS64_RS05920 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HXS64_RS05930 ENOG4105WP7 tRNA pseudouridine synthase C HXS64_RS05935 ENOG4105DR9 pseudouridine synthase HXS64_RS05940 ENOG4105QDK Flavodoxin HXS64_RS05945 ENOG4105DJB Major Facilitator Superfamily HXS64_RS05950 ENOG4105EQX glucarate dehydratase HXS64_RS05955 ENOG4105EQX glucarate dehydratase HXS64_RS05960 ENOG4105BZU Histidine kinase HXS64_RS05965 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HXS64_RS05970 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HXS64_RS05975 ENOG4106A2Z transcriptional regulator antitoxin, MazE HXS64_RS05980 ENOG4105MZG transcriptional modulator of maze toxin, mazf HXS64_RS05985 ENOG4105DXN mazG family HXS64_RS06010 ENOG4105HA9 of methanol dehydrogenase type HXS64_RS06020 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HXS64_RS06025 ENOG4108CWB sugar kinase ygcE HXS64_RS06030 ENOG4108ITV Inner membrane protein yqcE HXS64_RS06035 ENOG4105CHR reductase HXS64_RS06040 ENOG4107R3A FAD linked oxidase domain protein HXS64_RS06045 ENOG4105C54 Major Facilitator superfamily HXS64_RS06050 ENOG4106IKH Electron transfer flavoprotein HXS64_RS06055 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HXS64_RS06060 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HXS64_RS06065 ENOG4105WQV ferredoxin-like protein HXS64_RS06070 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HXS64_RS06075 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HXS64_RS06085 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HXS64_RS06095 ENOG4105DTT CRISPR-associated helicase, cas3 HXS64_RS06105 ENOG4105CYR Crispr-associated protein, cse1 family HXS64_RS06110 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) HXS64_RS06115 ENOG41060M0 Crispr-associated protein, cse4 family HXS64_RS06120 ENOG4108VWQ crispr-associated protein HXS64_RS06125 ENOG4108Y7V CRISPR-associated protein, Cse3 family HXS64_RS06130 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HXS64_RS06135 ENOG4105PWE CRISPR-associated protein cas2 HXS64_RS06140 ENOG4108MXK alkaline phosphatase isozyme conversion HXS64_RS06145 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HXS64_RS06150 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HXS64_RS06155 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HXS64_RS06160 ENOG4105N0Z inner membrane protein ygbE HXS64_RS06195 ENOG4108K5P (LipO)protein HXS64_RS06200 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HXS64_RS06205 ENOG4105C6Z Gluconate HXS64_RS06210 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HXS64_RS06215 ENOG4105FB2 class II Aldolase HXS64_RS06220 ENOG4105G63 Type III effector Hrp-dependent HXS64_RS06225 ENOG4105ZXK Dehydrogenase HXS64_RS06230 ENOG4105MVE transcriptional regulator HXS64_RS06235 ENOG4105MEW serine threonine protein phosphatase HXS64_RS06250 ENOG4105VXR cytoplasmic protein HXS64_RS06255 ENOG4108JUA Transcriptional regulator HXS64_RS06260 ENOG4105C45 hydrogenase expression formation protein (HypE) HXS64_RS06265 ENOG4105CQS hydrogenase expression formation protein HypD HXS64_RS06270 ENOG41083WG hydrogenase assembly chaperone HXS64_RS06275 ENOG4107RSS Hydrogenase accessory protein HypB HXS64_RS06280 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HXS64_RS06285 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HXS64_RS06290 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HXS64_RS06295 ENOG4107R30 NADH dehydrogenase HXS64_RS06300 ENOG4107TDF Formate hydrogenlyase subunit 4 HXS64_RS06305 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HXS64_RS06310 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HXS64_RS06315 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HXS64_RS06320 ENOG4105I6X formate hydrogenlyase maturation HXS64_RS06325 ENOG4108MG9 hydrogenase 3 maturation protease HXS64_RS06330 ENOG4105CS2 ec 3.2.1.21 HXS64_RS06335 ENOG4105C5Y PTS System HXS64_RS06340 ENOG4105DDV Transcriptional regulator (LacI family HXS64_RS06345 ENOG4108RC0 Electron transport protein HXS64_RS06350 ENOG4105C8H hydrogenase maturation protein Hypf HXS64_RS06355 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HXS64_RS06365 ENOG4108JUA Transcriptional regulator HXS64_RS06370 ENOG4105C2X Arabinose 5-phosphate isomerase HXS64_RS06375 ENOG410804X Transcriptional regulator HXS64_RS06380 ENOG4105J92 DNA-binding transcriptional activator GutM HXS64_RS06385 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HXS64_RS06390 ENOG4105VI0 Pts system, glucitol sorbitol-specific HXS64_RS06395 ENOG4105DZY Pts system, glucitol sorbitol-specific HXS64_RS06400 ENOG410787A Pts system, glucitol sorbitol-specific HXS64_RS06405 ENOG4105CVE Lytic murein transglycosylase HXS64_RS06410 ENOG4107TH8 cina domain protein HXS64_RS06425 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HXS64_RS06430 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HXS64_RS06460 ENOG4107VXZ Hydrolase HXS64_RS06465 ENOG4105W39 Membrane HXS64_RS06480 ENOG4105C0R drug resistance transporter emrb qaca subfamily HXS64_RS06485 ENOG4105CW7 secretion protein, HlyD family HXS64_RS06490 ENOG4105NTK Transcriptional repressor Mpra HXS64_RS06495 ENOG4105ZED uncharacterized protein ygaH HXS64_RS06500 ENOG4108UMN azlc family HXS64_RS06510 ENOG4105GIJ Glycine betaine HXS64_RS06515 ENOG4108HQS Glycine betaine HXS64_RS06520 ENOG4108IJ7 Glycine betaine HXS64_RS06525 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HXS64_RS06530 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HXS64_RS06540 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HXS64_RS06545 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HXS64_RS06550 ENOG4108WMJ Protein of unknown function (DUF2002) HXS64_RS06555 ENOG4108RNS Exports L-alanine (By similarity) HXS64_RS06560 ENOG4108X73 DNA- binding protein HXS64_RS06565 ENOG4108V62 Rhodanese domain protein HXS64_RS06570 ENOG41080HT Transcriptional regulator, arsr family HXS64_RS06575 ENOG4105VPI YqaE family transport protein HXS64_RS06580 ENOG4109066 lysm domain bon superfamily protein HXS64_RS06585 ENOG4108PVQ transcriptional regulator HXS64_RS06590 ENOG4105C85 amino acid HXS64_RS06595 ENOG4108JPW Aminotransferase HXS64_RS06600 ENOG4105C26 Dehydrogenase HXS64_RS06605 ENOG4105D5U fad dependent oxidoreductase HXS64_RS06610 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) HXS64_RS06620 ENOG4105E54 alpha-amylase HXS64_RS06650 ENOG4108MGN ATP-binding component of a transport system HXS64_RS06665 ENOG4108Z1B Cyclase dehydrase HXS64_RS06675 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HXS64_RS06680 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HXS64_RS06695 ENOG4108JU6 CBS domain protein HXS64_RS06700 ENOG4106KVJ cytochrome C assembly protein HXS64_RS06705 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HXS64_RS06735 ENOG4108KHX Diguanylate cyclase HXS64_RS06740 ENOG4108WS1 HXS64_RS06745 ENOG4105QP9 Protein of unknown function (DUF2799) HXS64_RS06750 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HXS64_RS06755 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HXS64_RS06760 ENOG4105CQC Prephenate dehydratase HXS64_RS06770 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HXS64_RS06775 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HXS64_RS06780 ENOG4105C34 Pseudouridine synthase HXS64_RS06785 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HXS64_RS06790 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HXS64_RS06815 ENOG4105CSH Transporter HXS64_RS06820 ENOG4105T42 (LipO)protein HXS64_RS06825 ENOG4105JIM Phosphatidylserine synthase HXS64_RS06830 ENOG4105CD5 CoA-binding domain protein HXS64_RS06835 ENOG4106IUH DTW domain containing protein HXS64_RS06840 ENOG4105K63 Thioredoxin HXS64_RS06845 ENOG4105EIB trna rrna methyltransferase HXS64_RS06865 ENOG41090KR LysR family transcriptional Regulator HXS64_RS06870 ENOG4105C1J atp-dependent rna helicase HXS64_RS06880 ENOG4108IYU L-aspartate oxidase HXS64_RS06890 ENOG4105EMN RNA polymerase sigma factor HXS64_RS06895 ENOG41069PW sigma-e factor negative regulatory protein HXS64_RS06900 ENOG4105VQK sigma E regulatory protein, MucB RseB HXS64_RS06905 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HXS64_RS06915 ENOG4105C3F Signal peptidase i HXS64_RS06935 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HXS64_RS06950 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HXS64_RS06955 ENOG4106G6Q Transcriptional regulator HXS64_RS06960 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HXS64_RS06965 ENOG4108Z6B deaminase HXS64_RS06980 ENOG4107WP9 Histidine kinase HXS64_RS06985 ENOG4108SKK alpha helix protein HXS64_RS06990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HXS64_RS07000 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HXS64_RS07010 ENOG4108NZE NAGC-like transcriptional regulator HXS64_RS07015 ENOG4107HQ7 repeat protein HXS64_RS07020 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HXS64_RS07025 ENOG4108F37 ATP-binding component of a transport system HXS64_RS07030 ENOG4105CNN ABC, transporter HXS64_RS07035 ENOG4105CPQ Dehydrogenase HXS64_RS07040 ENOG4108ZKT aldose 1-epimerase HXS64_RS07045 ENOG4108SB3 DoxX Family HXS64_RS07070 ENOG4105FUY alpha subunit HXS64_RS07075 ENOG4108W5M transcriptional regulator HXS64_RS07080 ENOG4105D8G Major Facilitator superfamily HXS64_RS07085 ENOG4108MN2 Stationary phase inducible protein CsiE HXS64_RS07090 ENOG4107XM9 (LipO)protein HXS64_RS07095 ENOG4105ECY inositol monophosphatase HXS64_RS07115 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HXS64_RS07135 ENOG4108ZIT Ferredoxin, 2FE-2S HXS64_RS07140 ENOG4105WVQ Fe-S assembly protein IscX HXS64_RS07145 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HXS64_RS07150 ENOG4105YYA enhanced serine sensitivity protein SseB HXS64_RS07155 ENOG4105KHC sulfurtransferase HXS64_RS07160 ENOG4105DN3 alpha-2-macroglobulin domain protein HXS64_RS07165 ENOG4108JQB penicillin-binding protein 1C HXS64_RS07195 ENOG4105N21 Membrane HXS64_RS07210 ENOG4105VPD cellular component movement HXS64_RS07215 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HXS64_RS07220 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HXS64_RS07225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HXS64_RS07230 ENOG41066DY Membrane HXS64_RS07235 ENOG4108ZMA Outer membrane lipoprotein HXS64_RS07240 ENOG41062G3 Protein of unknown function (DUF2633) HXS64_RS07250 ENOG4105BZU Histidine kinase HXS64_RS07255 ENOG4105C9X ppx gppa phosphatase HXS64_RS07260 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HXS64_RS07265 ENOG4108V3E phosphoribosylglycinamide formyltransferase HXS64_RS07280 ENOG4105C2W permease HXS64_RS07285 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HXS64_RS07290 ENOG4105K89 arsenate reductase HXS64_RS07295 ENOG4105ERG peptidase m48, ste24p HXS64_RS07300 ENOG4105C02 permease HXS64_RS07310 ENOG4108JUA Transcriptional regulator HXS64_RS07315 ENOG4105I6X formate hydrogenlyase maturation HXS64_RS07320 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HXS64_RS07330 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HXS64_RS07340 ENOG4107WQX hydrogenase 4 membrane subunit HXS64_RS07345 ENOG4105D65 subunit l HXS64_RS07350 ENOG4107TDF Formate hydrogenlyase subunit 4 HXS64_RS07360 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HXS64_RS07365 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HXS64_RS07370 ENOG4105RH4 Glycine cleavage system transcriptional repressor HXS64_RS07375 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HXS64_RS07380 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HXS64_RS07390 ENOG4105CGZ zinc metallopeptidase HXS64_RS07395 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HXS64_RS07400 ENOG4106KED esterase YpfH HXS64_RS07415 ENOG4105KUZ arsenate reductase HXS64_RS07430 ENOG4105BZU Histidine kinase HXS64_RS07435 ENOG4105BZ8 glutamate synthase HXS64_RS07445 ENOG4108PVD exported protein HXS64_RS07450 ENOG4105CV1 Transketolase (EC 2.2.1.1) HXS64_RS07455 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HXS64_RS07460 ENOG4105C6K Malic enzyme HXS64_RS07465 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HXS64_RS07470 ENOG4106S4J ethanolamine utilization protein EutP HXS64_RS07475 ENOG4105NDK ethanolamine utilization protein HXS64_RS07480 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HXS64_RS07485 ENOG4107WUY phosphate acetyltransferase HXS64_RS07490 ENOG4105KNY Microcompartments protein HXS64_RS07495 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HXS64_RS07500 ENOG4108EKI Dehydrogenase HXS64_RS07505 ENOG4107RWI ethanolamine utilization protein eutJ HXS64_RS07510 ENOG4105C0A alcohol dehydrogenase HXS64_RS07515 ENOG4105ENY Ethanolamine utilization protein eutH HXS64_RS07520 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HXS64_RS07530 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HXS64_RS07535 ENOG4105E5D amino acid HXS64_RS07540 ENOG4105CVK Glutamate decarboxylase HXS64_RS07545 ENOG4105CVK Glutamate decarboxylase HXS64_RS07580 ENOG4105DFP Integrase HXS64_RS07585 ENOG4105CPD ethanolamine ammonia-lyase HXS64_RS07595 ENOG4106D67 ethanolamine utilization protein HXS64_RS07600 ENOG4108X49 Ethanolamine utilization protein EutK HXS64_RS07605 ENOG4108K3Z AraC family transcriptional regulator HXS64_RS07615 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HXS64_RS07620 ENOG4108R6G acetyltransferase HXS64_RS07625 ENOG4105QZU Inner membrane protein YfeZ HXS64_RS07630 ENOG4105E7K (LipO)protein HXS64_RS07635 ENOG4105EZR dyp-type peroxidase family protein HXS64_RS07640 ENOG4107S1E Beta-lactamase HXS64_RS07645 ENOG4105C5Y PTS System HXS64_RS07655 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HXS64_RS07660 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HXS64_RS07665 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HXS64_RS07670 ENOG4108I5D sulfate abc transporter HXS64_RS07675 ENOG4105ECW sulfate abc transporter HXS64_RS07680 ENOG4108IJ6 ABC transporter HXS64_RS07685 ENOG4105C6T cysteine synthase HXS64_RS07690 ENOG4105WEC Molybdate metabolism regulator HXS64_RS07695 ENOG4105M0Y HXS64_RS07705 ENOG4105C5Y PTS System HXS64_RS07710 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HXS64_RS07720 ENOG4105C6T cysteine synthase HXS64_RS07735 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HXS64_RS07740 ENOG4105VRT cytoplasmic protein HXS64_RS07745 ENOG4105DHU Bile acid HXS64_RS07750 ENOG4108M0I Transcriptional regulator HXS64_RS07755 ENOG4108NFH Sugar hydrolase HXS64_RS07760 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HXS64_RS07765 ENOG4105EAA nucleoside HXS64_RS07775 ENOG4105CN8 Transcriptional regulator HXS64_RS07805 ENOG4105GXM Putative transcription regulator (DUF1323) HXS64_RS07810 ENOG4105HZG regulatoR HXS64_RS07825 ENOG4108KMM Diguanylate cyclase HXS64_RS07830 ENOG4105D9N nucleoside HXS64_RS07840 ENOG4109076 Conserved Protein HXS64_RS07845 ENOG4105VCT ion-transport protein YfeO HXS64_RS07855 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HXS64_RS07860 ENOG410863U PTS System HXS64_RS07865 ENOG4105DC7 peptidase M24 HXS64_RS07870 ENOG4105CN9 Peptidase m42 family protein HXS64_RS07875 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HXS64_RS07880 ENOG4108CIP transcriptional regulator HXS64_RS07885 ENOG4105DY9 regulatoR HXS64_RS07890 ENOG4108HRK Histidine kinase HXS64_RS07895 ENOG4105CHM Aminotransferase HXS64_RS07905 ENOG4105D1S lipid A biosynthesis HXS64_RS07910 ENOG4105W9M Membrane HXS64_RS07925 ENOG4108V08 YfdX protein HXS64_RS07935 ENOG4105CFN oxalyl-CoA decarboxylase HXS64_RS07940 ENOG4108N2Y auxin Efflux HXS64_RS07945 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HXS64_RS07950 ENOG4105BZU Histidine kinase HXS64_RS07955 ENOG4108WQH regulatoR HXS64_RS07960 ENOG4105CW7 secretion protein, HlyD family HXS64_RS07965 ENOG4105C0R drug resistance transporter emrb qaca subfamily HXS64_RS07975 ENOG4105C6Z Gluconate HXS64_RS07980 ENOG4105W8I Transcriptional regulator HXS64_RS07990 ENOG4105S64 Formate nitrite transporter HXS64_RS07995 ENOG410903C (LipO)protein HXS64_RS08005 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HXS64_RS08010 ENOG4105KZW UPF0381 protein HXS64_RS08015 ENOG4105CHU acetyl-coa acetyltransferase HXS64_RS08020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HXS64_RS08025 ENOG4108BY2 phosphohistidine phosphatase HXS64_RS08035 ENOG4106PG1 outer membrane usher protein HXS64_RS08040 ENOG4108FZ9 Chaperone HXS64_RS08045 ENOG4105NEV Fimbrial HXS64_RS08050 ENOG4105UGQ Fimbrial HXS64_RS08055 ENOG4105US4 fimbrial-like protein yfcP HXS64_RS08070 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HXS64_RS08080 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HXS64_RS08085 ENOG4105EJ9 Membrane HXS64_RS08090 ENOG4108BPE -transporting atpase HXS64_RS08095 ENOG4105MH2 YfcL protein HXS64_RS08100 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HXS64_RS08105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HXS64_RS08110 ENOG4105F9N Major Facilitator Superfamily HXS64_RS08115 ENOG4106WZ1 flagella biosynthesis regulator HXS64_RS08120 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HXS64_RS08125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HXS64_RS08135 ENOG4105DQR SNARE associated Golgi HXS64_RS08145 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HXS64_RS08150 ENOG4108S3P Sporulation domain protein HXS64_RS08155 ENOG4105E96 Colicin v production protein HXS64_RS08160 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HXS64_RS08165 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HXS64_RS08170 ENOG4105E89 ABC transporter HXS64_RS08175 ENOG4105E89 ABC transporter HXS64_RS08180 ENOG4105DSP amino acid AbC transporter HXS64_RS08185 ENOG4106YG3 ABC transporter HXS64_RS08190 ENOG4108JEH abc transporter atp-binding protein HXS64_RS08195 ENOG4105DNE Transposase HXS64_RS08200 ENOG4105ECP epimerase HXS64_RS08205 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HXS64_RS08210 ENOG4105CYM Glutathione S-transferase HXS64_RS08215 ENOG4108SHQ Glutathione S-transferase HXS64_RS08220 ENOG4108RE9 Phosphodiesterase HXS64_RS08225 ENOG4105PTV Nudix Hydrolase HXS64_RS08230 ENOG4105CSX c4-dicarboxylate anaerobic carrier HXS64_RS08235 ENOG4105C6K Malic enzyme HXS64_RS08240 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HXS64_RS08250 ENOG4105XWI UPF0304 protein HXS64_RS08255 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HXS64_RS08260 ENOG4107QWE )-transporter HXS64_RS08265 ENOG4105DK2 UPF0207 protein HXS64_RS08270 ENOG4105CHM Aminotransferase HXS64_RS08275 ENOG4107NQ8 LysR family Transcriptional regulator HXS64_RS08290 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HXS64_RS08295 ENOG4105GKE subunit e HXS64_RS08300 ENOG4107QIZ NADH dehydrogenase HXS64_RS08305 ENOG4107R0R NADH dehydrogenase subunit g HXS64_RS08320 ENOG4107UFS subunit j HXS64_RS08330 ENOG4105D65 subunit l HXS64_RS08335 ENOG4105C8S subunit m HXS64_RS08345 ENOG4106HDC HXS64_RS08350 ENOG4106EES HXS64_RS08355 ENOG4105ZD8 HXS64_RS08375 ENOG4107YB6 acetyltransferase, (GNAT) family HXS64_RS08380 ENOG4105TNS Conserved Protein HXS64_RS08385 ENOG4105E4F Isochorismate synthase HXS64_RS08400 ENOG4108IPT Naphthoate synthase HXS64_RS08410 ENOG4105CEY Amp-dependent synthetase and ligase HXS64_RS08415 ENOG4106GZG polymyxin resistance protein B HXS64_RS08420 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HXS64_RS08430 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HXS64_RS08440 ENOG4105C3I Nad-dependent epimerase dehydratase HXS64_RS08455 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) HXS64_RS08460 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HXS64_RS08465 ENOG4108UII YfaZ family HXS64_RS08470 ENOG4108EWA cinA-like protein HXS64_RS08475 ENOG4107258 Transcriptional regulator HXS64_RS08480 ENOG4105CXK mandelate racemase muconate lactonizing HXS64_RS08485 ENOG4105CSP Major Facilitator Superfamily HXS64_RS08500 ENOG4105DNE Transposase HXS64_RS08505 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HXS64_RS08510 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HXS64_RS08515 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HXS64_RS08520 ENOG4105CXY transporter HXS64_RS08525 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HXS64_RS08535 ENOG4105FQR PH-inducible protein involved in stress response HXS64_RS08540 ENOG4105XPH Ferredoxin HXS64_RS08545 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HXS64_RS08550 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HXS64_RS08555 ENOG4107GHC outer membrane autotransporter HXS64_RS08565 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HXS64_RS08570 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HXS64_RS08575 ENOG4108QJJ Protein of unknown function (DUF1175) HXS64_RS08580 ENOG4107S52 alpha-2-macroglobulin domain protein HXS64_RS08585 ENOG41081SK signal peptide protein HXS64_RS08590 ENOG4105EDV vault protein HXS64_RS08595 ENOG4105CHU acetyl-coa acetyltransferase HXS64_RS08600 ENOG4105CRW Short chain fatty acid transporter HXS64_RS08605 ENOG4107QNJ CoA-transferase subunit B HXS64_RS08610 ENOG4107QP7 CoA-transferase subunit A HXS64_RS08615 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HXS64_RS08620 ENOG4105BZU Histidine kinase HXS64_RS08625 ENOG4105BZU Histidine kinase HXS64_RS08630 ENOG41068CG regulatoR HXS64_RS08635 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HXS64_RS08640 ENOG4105FCK Membrane HXS64_RS08645 ENOG4105CJ2 (LipO)protein HXS64_RS08650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HXS64_RS08655 ENOG4105CF1 Alkylated DNA repair protein HXS64_RS08660 ENOG4105IBP Cyclic peptide transporter HXS64_RS08665 ENOG4105DWT malate dehydrogenase (quinone) HXS64_RS08680 ENOG4108ZNS ferredoxin-type protein NapF HXS64_RS08685 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HXS64_RS08690 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HXS64_RS08695 ENOG4108BGM Quinol dehydrogenase periplasmic component HXS64_RS08700 ENOG4105GXZ Ferredoxin-type protein NapH HXS64_RS08705 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HXS64_RS08710 ENOG4105CUW cytochrome C-TYPE protein HXS64_RS08715 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HXS64_RS08720 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HXS64_RS08725 ENOG41060IM Heme exporter protein HXS64_RS08730 ENOG4105X3C heme exporter protein HXS64_RS08740 ENOG4105DA4 cytochrome c-type biogenesis protein HXS64_RS08745 ENOG4107QX9 Thiol disulfide interChange protein HXS64_RS08750 ENOG4105KWW Biogenesis protein HXS64_RS08755 ENOG4105WH1 Two component transcriptional regulator luxr family HXS64_RS08760 ENOG4108MGN ATP-binding component of a transport system HXS64_RS08770 ENOG4105E68 Sulfatase HXS64_RS08790 ENOG4105CFI type iii restriction protein res subunit HXS64_RS08795 ENOG4105I08 Pseudouridine synthase HXS64_RS08800 ENOG4105C2C drug resistance transporter, Bcr CflA HXS64_RS08805 ENOG4105HG6 HXS64_RS08810 ENOG4108JQ5 ABC transporter HXS64_RS08815 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HXS64_RS08820 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HXS64_RS08825 ENOG4105E43 Extracellular solute-binding protein, family 5 HXS64_RS08830 ENOG4105CXC rtn protein HXS64_RS08835 ENOG4107TT5 NLP P60 protein HXS64_RS08840 ENOG41076MN Phosphoesterase, PA-phosphatase related HXS64_RS08845 ENOG4105CKI cobalamin synthesis protein HXS64_RS08850 ENOG4105DEI Mannitol dehydrogenase HXS64_RS08860 ENOG4105KRS Proteinase inhibitor HXS64_RS08865 ENOG4105S8Q sugar efflux transporter HXS64_RS08870 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HXS64_RS08875 ENOG4105DE4 1-phosphofructokinase HXS64_RS08880 ENOG4105DM4 PTS System HXS64_RS08885 ENOG4105DD7 kinase (PfkB family HXS64_RS08890 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HXS64_RS08895 ENOG4105D9N nucleoside HXS64_RS08900 ENOG4108Y4K DNA-binding transcriptional activator HXS64_RS08910 ENOG4105D9N nucleoside HXS64_RS08915 ENOG4105DD7 kinase (PfkB family HXS64_RS08920 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HXS64_RS08925 ENOG4105HMI Membrane HXS64_RS08930 ENOG4105DUM transcriptional regulator, lysR family HXS64_RS08935 ENOG4108IQI permease HXS64_RS08940 ENOG4105D05 Receptor HXS64_RS08955 ENOG4105DHF Membrane HXS64_RS08960 ENOG41060NJ transcriptional regulator HXS64_RS08965 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HXS64_RS08970 ENOG4105C2J ABC transporter HXS64_RS08975 ENOG4108HWV )-transporter HXS64_RS08980 ENOG4107SJI Dehydrogenase HXS64_RS08985 ENOG4105BZ8 glutamate synthase HXS64_RS08990 ENOG4105Y9N Membrane HXS64_RS08995 ENOG4107GZ4 SanA protein HXS64_RS09005 ENOG41067MG lrgb family HXS64_RS09015 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HXS64_RS09030 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HXS64_RS09035 ENOG4105KHU inner membrane protein YohD HXS64_RS09040 ENOG41069YE inner membrane protein yohC HXS64_RS09045 ENOG41061WM D-Alanyl-D-Alanine HXS64_RS09050 ENOG4105CXG d-lactate dehydrogenase HXS64_RS09055 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HXS64_RS09060 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HXS64_RS09065 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HXS64_RS09070 ENOG4108IJ8 ABC transporter HXS64_RS09075 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HXS64_RS09085 ENOG4108XDN Transcriptional regulator HXS64_RS09090 ENOG4108HRK Histidine kinase HXS64_RS09095 ENOG4108NEV two component transcriptional regulator, LytTR family HXS64_RS09100 ENOG4108W15 Protein of unknown function (DUF1456) HXS64_RS09105 ENOG4108YCW (LipO)protein HXS64_RS09110 ENOG410903U zinc ion binding HXS64_RS09115 ENOG4105DEG Vwa containing coxe family protein HXS64_RS09120 ENOG4105RD5 HXS64_RS09125 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HXS64_RS09135 ENOG4108KDT Molybdate metabolism regulator HXS64_RS09145 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HXS64_RS09150 ENOG4105D1F ATP-binding protein HXS64_RS09155 ENOG41067AK Protein of unknown function (DUF2574) HXS64_RS09160 ENOG41063W2 Fimbrial protein HXS64_RS09165 ENOG4108MQF Chaperone HXS64_RS09170 ENOG4105CW0 outer membrane usher protein HXS64_RS09175 ENOG410662B Type-1 fimbrial protein HXS64_RS09180 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HXS64_RS09200 ENOG4105DWF phosphomethylpyrimidine kinase HXS64_RS09205 ENOG4108UQ1 hydrolase, family 25 HXS64_RS09210 ENOG4105FDP GntR family transcriptional regulator HXS64_RS09215 ENOG4108TFM Kinase, PfkB family HXS64_RS09220 ENOG4108KD5 ADP-ribosylation crystallin J1 HXS64_RS09225 ENOG4105EAA nucleoside HXS64_RS09230 ENOG4105EIE fructose-bisphosphate aldolase HXS64_RS09235 ENOG4105IE8 Alpha-ketoglutarate permease HXS64_RS09240 ENOG4105EF1 ribulokinase HXS64_RS09260 ENOG4105DEI Mannitol dehydrogenase HXS64_RS09265 ENOG4105CMG Carbohydrate kinase HXS64_RS09270 ENOG4105IE8 Alpha-ketoglutarate permease HXS64_RS09275 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HXS64_RS09285 ENOG41076Z6 Uncharacterized protein yegR HXS64_RS09290 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HXS64_RS09335 ENOG4105VZ1 Replication Protein HXS64_RS09355 ENOG4105ED4 portal protein HXS64_RS09450 ENOG4105PTU response to oxidative stress HXS64_RS09455 ENOG4108US3 tail fiber assembly HXS64_RS09465 ENOG4108C33 Resolvase HXS64_RS09505 ENOG4105ZTC transcriptional activator, Ogr delta HXS64_RS09510 ENOG4105CFP Peptidase U32 HXS64_RS09515 ENOG4105KWI UPF0339 protein HXS64_RS09520 ENOG4105E3W Two component transcriptional regulator (Winged helix family HXS64_RS09525 ENOG4105EB3 Histidine kinase HXS64_RS09535 ENOG4105BZS acriflavin resistance protein HXS64_RS09540 ENOG4105BZS acriflavin resistance protein HXS64_RS09565 ENOG4108M24 von Willebrand factor, type A HXS64_RS09570 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HXS64_RS09580 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HXS64_RS09585 ENOG4105R8A Heat shock protein HXS64_RS09590 ENOG4105D03 DNA-3-methyladenine glycosylase II HXS64_RS09595 ENOG4105BZU Histidine kinase HXS64_RS09600 ENOG4105DBI uridine monophosphokinase HXS64_RS09610 ENOG4108GAE asmA family HXS64_RS09615 ENOG4105EE5 Membrane protein terC HXS64_RS09625 ENOG4105DAY polysaccharide export protein HXS64_RS09630 ENOG4105KJF protein tyrosine phosphatase HXS64_RS09635 ENOG4105D75 Capsular exopolysaccharide family HXS64_RS09640 ENOG41090RK glycosyl transferase HXS64_RS09645 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HXS64_RS09650 ENOG4107RXY Glycosyl transferase HXS64_RS09655 ENOG4108NYJ Colanic acid HXS64_RS09660 ENOG4105ECJ Glycosyl Transferase HXS64_RS09665 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HXS64_RS09670 ENOG4105C0K Gdp-mannose 4,6-dehydratase HXS64_RS09675 ENOG4105C30 Nad-dependent epimerase dehydratase HXS64_RS09680 ENOG4105FGF GDP-mannose mannosyl hydrolase HXS64_RS09685 ENOG4106CD9 glycosyl transferase group 1 HXS64_RS09690 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HXS64_RS09695 ENOG4107QKV phosphomannomutase HXS64_RS09700 ENOG4105D3Q Sugar transferase HXS64_RS09705 ENOG4105PSV Polysaccharide Biosynthesis Protein HXS64_RS09710 ENOG4105C74 pyruvyl transferase HXS64_RS09715 ENOG4107T8Q Glycosyl transferase (Group 1 HXS64_RS09720 ENOG4105G1A colanic acid biosynthesis protein HXS64_RS09725 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HXS64_RS09740 ENOG4105K64 Glycosyl transferase, family 2 HXS64_RS09755 ENOG4105CMR udp-glucose 4-epimerase HXS64_RS09765 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HXS64_RS09770 ENOG4107QKV phosphomannomutase HXS64_RS09775 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HXS64_RS09785 ENOG4105C6Y Udp-glucose 6-dehydrogenase HXS64_RS09790 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HXS64_RS09795 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HXS64_RS09810 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HXS64_RS09815 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HXS64_RS09825 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HXS64_RS09840 ENOG4107SRH Nad-dependent epimerase dehydratase HXS64_RS09845 ENOG4105EQ1 Transcriptional regulator HXS64_RS09855 ENOG4105CUB amino acid HXS64_RS09860 ENOG4105CUC YeeE YedE family protein HXS64_RS09870 ENOG4105CJB Exodeoxyribonuclease I HXS64_RS09880 ENOG4105DZ1 carboxypeptidase HXS64_RS09890 ENOG4105DR8 Membrane HXS64_RS09925 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HXS64_RS09940 ENOG4105MFG Antirestriction protein HXS64_RS09945 ENOG4106H6R UPF0380 protein HXS64_RS09985 ENOG4108PXI ErfK YbiS YcfS YnhG HXS64_RS09995 ENOG4106P55 Transcriptional regulator HXS64_RS10000 ENOG4107R11 Transcriptional regulator HXS64_RS10010 ENOG4105UQX Mate efflux family protein HXS64_RS10020 ENOG4105CDY transcriptional regulatory protein HXS64_RS10025 ENOG4105FYV Amp nucleosidase HXS64_RS10030 ENOG4105CSH Transporter HXS64_RS10040 ENOG4108VKM cytochrome b561 HXS64_RS10050 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HXS64_RS10070 ENOG4108MEK Metal-binding protein YodA HXS64_RS10085 ENOG4105VT2 5-hydroxyisourate hydrolase HXS64_RS10090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HXS64_RS10095 ENOG4107ZY3 Histidine kinase HXS64_RS10100 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) HXS64_RS10105 ENOG4105ZIT Porin Gram-negative type HXS64_RS10110 ENOG4105Y0K Inner membrane protein YedR HXS64_RS10115 ENOG4105EST Metal Dependent Phosphohydrolase HXS64_RS10120 ENOG4105DVF Cytosine-specific methyltransferase HXS64_RS10125 ENOG41090BB DNA mismatch endonuclease (vsr) HXS64_RS10130 ENOG4105FDR Membrane HXS64_RS10135 ENOG4105CKW Inner membrane protein yedI HXS64_RS10140 ENOG4105VNZ cytoplasmic protein HXS64_RS10155 ENOG4105YX3 cellular response to acidity HXS64_RS10165 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HXS64_RS10170 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HXS64_RS10180 ENOG4105CN7 Flagellar biosynthetic protein FliP HXS64_RS10185 ENOG4105K0P flagellar biosynthesis protein HXS64_RS10190 ENOG4105DD5 Flagellar motor switch protein HXS64_RS10195 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HXS64_RS10200 ENOG4107ZI8 flagellar basal body-associated protein flil HXS64_RS10205 ENOG4105WF4 Flagellar hook-length control protein HXS64_RS10210 ENOG4105GSA Flagellar export protein flij HXS64_RS10215 ENOG4108JIR Flagellum-specific ATP synthase HXS64_RS10220 ENOG41090PJ Flagellar assembly protein HXS64_RS10225 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HXS64_RS10230 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HXS64_RS10235 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HXS64_RS10240 ENOG410814C multidrug resistance protein HXS64_RS10245 ENOG4108V1U phospholipid-binding protein HXS64_RS10250 ENOG4108UQN AraC family transcriptional regulator HXS64_RS10265 ENOG4105D7V transposase HXS64_RS10270 ENOG4108RAV Conserved protein HXS64_RS10280 ENOG41066VF YeeE YedE family protein HXS64_RS10285 ENOG4108W9D (LipO)protein HXS64_RS10290 ENOG4105E5K Alpha-amylase HXS64_RS10300 ENOG4105MQ3 flagellar protein FliS HXS64_RS10305 ENOG4105DTS flagellar hook-associated HXS64_RS10315 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HXS64_RS10320 ENOG4108M9K flagella biosynthesis protein FliZ HXS64_RS10325 ENOG4105EAB amino acid AbC transporter HXS64_RS10335 ENOG4105E5Q amino acid AbC transporter HXS64_RS10340 ENOG4105CDA abc transporter atp-binding protein HXS64_RS10345 ENOG4105VJY transcriptional regulator HXS64_RS10350 ENOG4105XVG cytoplasmic protein HXS64_RS10360 ENOG4105WH1 Two component transcriptional regulator luxr family HXS64_RS10390 ENOG4106RHG Yeca family HXS64_RS10395 ENOG4105E0U tyrosine-specific transport protein HXS64_RS10400 ENOG4105VVZ metal-binding protein HXS64_RS10405 ENOG41090A1 ferritin HXS64_RS10410 ENOG4105P23 (LipO)protein HXS64_RS10420 ENOG4105N4N Protein of unknown function (DUF2766) HXS64_RS10425 ENOG4108UEC Ferritin-like protein HXS64_RS10430 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HXS64_RS10435 ENOG4105C2J ABC transporter HXS64_RS10440 ENOG4105CNN ABC, transporter HXS64_RS10445 ENOG4108K4C ec 3.1.3.12 HXS64_RS10455 ENOG4108VA4 Universal stress protein HXS64_RS10465 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HXS64_RS10470 ENOG4107RD7 Flagellar Motor Protein, MotA HXS64_RS10475 ENOG4105ER2 Ompa motb domain protein HXS64_RS10480 ENOG4105CBS Chea signal transduction histidine kinase HXS64_RS10485 ENOG4108V3W Chemotaxis protein, CheW HXS64_RS10490 ENOG4105C8Q Methyl-accepting chemotaxis HXS64_RS10495 ENOG4105C8Q Methyl-accepting chemotaxis HXS64_RS10500 ENOG4105BZU Histidine kinase HXS64_RS10510 ENOG4108VYJ response regulator receiver protein HXS64_RS10515 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HXS64_RS10520 ENOG4105D00 flagellar biosynthetic protein flhB HXS64_RS10525 ENOG4105D7B Flagellar biosynthesis protein flha HXS64_RS10530 ENOG4105W13 flagellar protein HXS64_RS10540 ENOG4105C75 arginyL-tRNA synthetase HXS64_RS10545 ENOG4106ZCM YecM protein HXS64_RS10555 ENOG4105CUW cytochrome C-TYPE protein HXS64_RS10560 ENOG4107QY8 reductase HXS64_RS10575 ENOG4105WJG Glutathione HXS64_RS10580 ENOG41081XQ Conserved Protein HXS64_RS10585 ENOG4105D3W isochorismatase HXS64_RS10595 ENOG4108TIT dATP pyrophosphohydrolase HXS64_RS10600 ENOG4105CDY transcriptional regulatory protein HXS64_RS10610 ENOG4107S01 Repressor protein MetJ HXS64_RS10630 ENOG4105FAV ABC, transporter HXS64_RS10640 ENOG4105NXV High-affinity zinc uptake system protein HXS64_RS10645 ENOG4105DR5 peptidase HXS64_RS10650 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HXS64_RS10655 ENOG4105CA9 Pyruvate kinase HXS64_RS10660 ENOG4106KNT transcriptional regulator HXS64_RS10665 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HXS64_RS10670 ENOG4105C01 Dihydroxy-acid dehydratase HXS64_RS10675 ENOG4108UHU Aldolase HXS64_RS10680 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HXS64_RS10685 ENOG4105X2V dna damage-inducible protein HXS64_RS10695 ENOG4108Q2J Inner membrane protein YebE HXS64_RS10700 ENOG4105CUG Oligopeptidase b HXS64_RS10705 ENOG4105UMD exodeoxyribonuclease X HXS64_RS10710 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HXS64_RS10715 ENOG4105MPK DNA polymerase III subunit theta HXS64_RS10720 ENOG4105FXM Copper resistance protein HXS64_RS10725 ENOG4108PNC copper resistance HXS64_RS10730 ENOG4105NKT exported protein HXS64_RS10750 ENOG4105UVW uncharacterized protein yebW HXS64_RS10755 ENOG4105WT8 Protein of unknown function (DUF1480) HXS64_RS10765 ENOG4105DY2 Paraquat-inducible protein b HXS64_RS10770 ENOG4105H2K paraquat-inducible protein a HXS64_RS10775 ENOG4108ZGC gaf domain protein HXS64_RS10785 ENOG4105CN1 protease HXS64_RS10795 ENOG4105C0R drug resistance transporter emrb qaca subfamily HXS64_RS10800 ENOG4105J4Q Transcriptional regulator HXS64_RS10805 ENOG4105TIK HXS64_RS10815 ENOG4105Q3Y exported protein HXS64_RS10830 ENOG4105DHI Methyltransferase HXS64_RS10845 ENOG4105F3R pts system mannose fructose sorbose family iid HXS64_RS10850 ENOG4105ETZ PTS System HXS64_RS10855 ENOG4105DAS pts system HXS64_RS10860 ENOG4105EE5 Membrane protein terC HXS64_RS10865 ENOG4107XTP (EAL) domain protein HXS64_RS10870 ENOG4105EJQ L-serine dehydratase HXS64_RS10875 ENOG4105P8F nudix hydrolase HXS64_RS10880 ENOG4105CRQ synthase (Component I) HXS64_RS10890 ENOG4105V2F Uncharacterized protein yoac HXS64_RS10895 ENOG4105M4H endoribonuclease L-psp HXS64_RS10900 ENOG4105DVT helicase HXS64_RS10905 ENOG41072GX Peptidase M22 Glycoprotease HXS64_RS10910 ENOG4105Y4Z Outer Membrane Lipoprotein HXS64_RS10915 ENOG4105CEY Amp-dependent synthetase and ligase HXS64_RS10920 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HXS64_RS10925 ENOG4105E3J oxidoreductase HXS64_RS10930 ENOG4105DVW rieske (2Fe-2S) HXS64_RS10940 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HXS64_RS10945 ENOG4105EJC lysr family transcriptional regulator HXS64_RS10955 ENOG4108YS1 cytoplasmic protein HXS64_RS10960 ENOG4105YP6 Domain of unknown function (DUF1869) HXS64_RS10965 ENOG4105Y3U Transglycosylase-associated protein HXS64_RS10975 ENOG4106G4W HXS64_RS10980 ENOG410620I Diguanylate cyclase HXS64_RS10985 ENOG4105UCG Domain of unknown function (DUF333) HXS64_RS10990 ENOG4105K78 MarR family Transcriptional regulator HXS64_RS10995 ENOG4105DJ2 Major Facilitator Superfamily HXS64_RS11000 ENOG4105R1U AraC Family Transcriptional Regulator HXS64_RS11015 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HXS64_RS11020 ENOG4108KHP Diguanylate cyclase HXS64_RS11025 ENOG4106KTS Inner membrane protein yeaI HXS64_RS11035 ENOG4105CYN Serine protein kinase HXS64_RS11040 ENOG4105GNX MltA-interacting MipA family protein HXS64_RS11045 ENOG4105CV8 reductase HXS64_RS11050 ENOG4105DSB aldose 1-epimerase HXS64_RS11055 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HXS64_RS11065 ENOG4105VUT cytoplasmic protein HXS64_RS11070 ENOG4105CPQ Dehydrogenase HXS64_RS11075 ENOG4107TE1 transport protein HXS64_RS11080 ENOG4105CPQ Dehydrogenase HXS64_RS11095 ENOG4107UH8 sugar kinase HXS64_RS11100 ENOG4105CPC Aldo Keto reductase HXS64_RS11105 ENOG4105E98 transcriptional regulator DeoR family HXS64_RS11110 ENOG4108KUU Inner membrane metabolite transport protein ydjE HXS64_RS11115 ENOG4108RWI nicotinamidase HXS64_RS11120 ENOG4105HDK L-asparaginase HXS64_RS11125 ENOG4105D07 Signal peptide peptidase, SppA HXS64_RS11130 ENOG41069NU Nitroreductase HXS64_RS11140 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HXS64_RS11145 ENOG41065FB inner membrane protein ynji HXS64_RS11155 ENOG4105MTM Protein of unknown function (DUF1496) HXS64_RS11160 ENOG4105M6F mutator MutT protein HXS64_RS11165 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HXS64_RS11170 ENOG4107RM6 sulfurtransferase HXS64_RS11175 ENOG4108VGW abc transporter atp-binding protein HXS64_RS11180 ENOG4105CXZ ABC transporter, permease HXS64_RS11185 ENOG4105VNH ABC transporter solute-binding protein HXS64_RS11190 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HXS64_RS11195 ENOG4108N5C SNARE associated Golgi protein-related protein HXS64_RS11200 ENOG4108KCW iron-sulfur cluster binding HXS64_RS11205 ENOG4108RSN SNARE associated Golgi HXS64_RS11210 ENOG4105CGK Exodeoxyribonuclease III HXS64_RS11230 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HXS64_RS11240 ENOG4108SPG Periplasmic Protein HXS64_RS11250 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HXS64_RS11260 ENOG4105KKI DNA-binding transcriptional activator OsmE HXS64_RS11265 ENOG4105VZJ PTS System HXS64_RS11270 ENOG4105CK1 PTS System HXS64_RS11275 ENOG4105VCP PTS System HXS64_RS11280 ENOG4105EZV Transcriptional regulator HXS64_RS11285 ENOG4105F8D glycoside hydrolase family 4 HXS64_RS11290 ENOG410901P UPF0249 protein HXS64_RS11295 ENOG4105CH6 catalase HXS64_RS11310 ENOG4108ETY sodium dicarboxylate symporter HXS64_RS11315 ENOG4107K5X Membrane-bound metal-dependent hydrolase HXS64_RS11320 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HXS64_RS11325 ENOG4107PN8 YfeABCD locus regulator HXS64_RS11335 ENOG4105P10 Uncharacterized protein ydiZ HXS64_RS11340 ENOG4105DE4 1-phosphofructokinase HXS64_RS11345 ENOG4108NE3 Salt-induced outer membrane protein HXS64_RS11365 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HXS64_RS11370 ENOG41082NX 50s ribosomal protein l35 HXS64_RS11390 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HXS64_RS11405 ENOG4108V06 Glutathione peroxidase HXS64_RS11415 ENOG4108QBX (LipO)protein HXS64_RS11420 ENOG4108TC0 Diguanylate phosphodiesterase HXS64_RS11425 ENOG4105CNG UPF0061 protein HXS64_RS11435 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HXS64_RS11445 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HXS64_RS11450 ENOG4105CEY Amp-dependent synthetase and ligase HXS64_RS11455 ENOG41090P5 ferredoxin-like protein HXS64_RS11460 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HXS64_RS11465 ENOG4105C10 Electron transfer flavoprotein HXS64_RS11470 ENOG4105CV7 Electron transfer flavoprotein HXS64_RS11475 ENOG4105W4W Transcriptional regulator HXS64_RS11480 ENOG4105C1G acyl-Coa dehydrogenase HXS64_RS11485 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HXS64_RS11515 ENOG4105IPI Membrane HXS64_RS11520 ENOG4105CQB FAD linked oxidase domain protein HXS64_RS11525 ENOG4105KA0 thioesterase Superfamily protein HXS64_RS11530 ENOG410671Z uncharacterized protein ydiH HXS64_RS11535 ENOG4108Z4V iron-sulfur cluster assembly HXS64_RS11540 ENOG4105DIW FeS assembly protein SUFB HXS64_RS11545 ENOG4105C3K feS assembly ATPase SufC HXS64_RS11550 ENOG4105JRK feS assembly protein SufD HXS64_RS11555 ENOG4105C9B Cysteine desulfurase HXS64_RS11565 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HXS64_RS11570 ENOG4105KMX major outer membrane lipoprotein HXS64_RS11575 ENOG4105CA9 Pyruvate kinase HXS64_RS11580 ENOG4105RFR Protein of unknown function (DUF2767) HXS64_RS11585 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HXS64_RS11590 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HXS64_RS11595 ENOG4105JVW HXS64_RS11600 ENOG4108393 oxidoreductase Fe-S subunit HXS64_RS11605 ENOG4108NWD Cytochrome HXS64_RS11610 ENOG4108Y7C Conserved Protein HXS64_RS11615 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HXS64_RS11620 ENOG4105N0V mono-oxygenase ydhR HXS64_RS11640 ENOG4107QI1 Mate efflux family protein HXS64_RS11645 ENOG4108R6K riboflavin synthase, subunit alpha HXS64_RS11650 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HXS64_RS11655 ENOG4105CZQ inner membrane transport protein YdhC HXS64_RS11660 ENOG4105F52 Transcriptional regulator HXS64_RS11675 ENOG4105F27 Major Facilitator HXS64_RS11680 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HXS64_RS11685 ENOG4105K4H Nlp p60 protein HXS64_RS11695 ENOG4105M2J Glutaredoxin HXS64_RS11700 ENOG4107QRT dEAD DEAH box helicase HXS64_RS11705 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HXS64_RS11710 ENOG4108UYE Lactoylglutathione lyase HXS64_RS11715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HXS64_RS11720 ENOG4108WUH Transcriptional regulator, TetR family HXS64_RS11725 ENOG4105XZD Fe-S protein HXS64_RS11730 ENOG4107RGM aldo keto reductase HXS64_RS11735 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HXS64_RS11740 ENOG4105DSW Fusaric acid resistance protein HXS64_RS11745 ENOG4105Y49 secretion protein, HlyD family HXS64_RS11760 ENOG4108XTF Outer Membrane Lipoprotein HXS64_RS11770 ENOG410642K Lysozyme inhibitor HXS64_RS11785 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HXS64_RS11790 ENOG4108K3A Glutathione S-transferase HXS64_RS11795 ENOG4105DUX Transporter HXS64_RS11800 ENOG4105CSM endonuclease III HXS64_RS11810 ENOG4108UQQ Electron transport complex HXS64_RS11835 ENOG4105M9B inner membrane protein ydgK HXS64_RS11840 ENOG4105QZ5 OriC-binding nucleoid-associated protein HXS64_RS11845 ENOG4106C6R beta-lactam resistance protein HXS64_RS11850 ENOG4105D9R oxidoreductase HXS64_RS11860 ENOG4105C87 Aminotransferase class I and II HXS64_RS11865 ENOG4105CI1 PTS System HXS64_RS11870 ENOG4107P2S Transcriptional regulator HXS64_RS11875 ENOG4107ZQV short-chain dehydrogenase reductase HXS64_RS11880 ENOG4105XEA Tetr family transcriptional regulator HXS64_RS11890 ENOG4105CT4 transporter HXS64_RS11895 ENOG4108QNI outer membrane porin protein HXS64_RS11900 ENOG4106J39 exported protein HXS64_RS11905 ENOG4105EIP mannose-6-phosphate isomerase HXS64_RS11910 ENOG4107GFK fumarate HXS64_RS11915 ENOG4105C9Q fumarate hydratase class II HXS64_RS11920 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HXS64_RS11925 ENOG4105JJR Histidine kinase HXS64_RS11930 ENOG4107EXC regulatoR HXS64_RS11935 ENOG4105RA2 Membrane HXS64_RS11945 ENOG4105D5Q Arginine ornithine antiporter HXS64_RS11950 ENOG4105C5D exported protein HXS64_RS11955 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HXS64_RS11960 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HXS64_RS11965 ENOG4105DSF transport protein HXS64_RS11980 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HXS64_RS11995 ENOG4105D94 Major Facilitator Superfamily HXS64_RS12000 ENOG4106NZI LysR family Transcriptional regulator HXS64_RS12005 ENOG4105DAG ROK family HXS64_RS12010 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HXS64_RS12020 ENOG4108NEM leader-binding protein dmsD HXS64_RS12025 ENOG4107KGK dmso reductase anchor subunit HXS64_RS12030 ENOG4105QAX Iron-sulfur HXS64_RS12035 ENOG4105C3J Cysteine desulfurase HXS64_RS12040 ENOG4107QY8 reductase HXS64_RS12045 ENOG4105KBG Protein of unknown function (DUF1161) HXS64_RS12050 ENOG4105D69 UPF0257 lipoprotein ynfC HXS64_RS12055 ENOG4108MK9 spermidine N(1)-acetyltransferase HXS64_RS12070 ENOG4105CXK mandelate racemase muconate lactonizing HXS64_RS12075 ENOG4105CPQ Dehydrogenase HXS64_RS12085 ENOG4107R08 Integrase HXS64_RS12100 ENOG4106G8A Qin prophage HXS64_RS12135 ENOG41087BU transcriptional repressor DicA HXS64_RS12165 ENOG4105WPN DNA integration recombination invertion protein HXS64_RS12175 ENOG4105WI6 cell killing protein encoded within cryptic prophage HXS64_RS12190 ENOG4108MXB Protein of unknown function (DUF968) HXS64_RS12195 ENOG4105HRS Antitermination protein HXS64_RS12205 ENOG4107SEY Conserved Protein HXS64_RS12210 ENOG4105F2I Transposase HXS64_RS12220 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HXS64_RS12235 ENOG4108YV9 Protein of unknown function (DUF2514) HXS64_RS12240 ENOG4105VEQ Cold shock protein HXS64_RS12255 ENOG4106IAW HXS64_RS12260 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HXS64_RS12295 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HXS64_RS12395 ENOG4105MN3 Resolvase HXS64_RS12400 ENOG4105W3V DNA-binding, transcriptional regulator HXS64_RS12415 ENOG4105DEI Mannitol dehydrogenase HXS64_RS12420 ENOG41061EV selenium-binding protein YdfZ HXS64_RS12425 ENOG4107XBN GntR Family Transcriptional Regulator HXS64_RS12430 ENOG4105EMU Dehydrogenase HXS64_RS12435 ENOG4105DGW oligopeptidase A HXS64_RS12440 ENOG4108WTK competence damage-inducible protein HXS64_RS12445 ENOG4108YDI single-species biofilm formation on inanimate substrate HXS64_RS12450 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HXS64_RS12460 ENOG4105E5W Transporter HXS64_RS12465 ENOG4108594 Permease of the drug metabolite transporter HXS64_RS12470 ENOG4106DNR multiple antibiotic resistance protein HXS64_RS12475 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HXS64_RS12480 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HXS64_RS12510 ENOG4105EGI Transcriptional regulator HXS64_RS12515 ENOG4105C26 Dehydrogenase HXS64_RS12520 ENOG4105CSV Glutaminase HXS64_RS12525 ENOG4105M0C cytoplasmic protein HXS64_RS12540 ENOG4105FFC UPF0187 protein HXS64_RS12545 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HXS64_RS12550 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HXS64_RS12555 ENOG41061GT Aldolase HXS64_RS12560 ENOG4105D4B ABC, transporter HXS64_RS12570 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HXS64_RS12575 ENOG4105C2J ABC transporter HXS64_RS12595 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HXS64_RS12600 ENOG4105CAF HipA N-terminal domain protein HXS64_RS12615 ENOG4106PIH fimbrial-like protein ydeQ HXS64_RS12620 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HXS64_RS12630 ENOG4105Z68 AraC Family Transcriptional Regulator HXS64_RS12640 ENOG4105C4X radical SAM domain protein HXS64_RS12650 ENOG4105CQ0 ABC transporter HXS64_RS12655 ENOG4105PE1 Receptor HXS64_RS12660 ENOG4107RAN Peptidase, M16 HXS64_RS12665 ENOG4105CVK Glutamate decarboxylase HXS64_RS12670 ENOG4105E5D amino acid HXS64_RS12675 ENOG4105F32 YngK protein HXS64_RS12680 ENOG4105BZU Histidine kinase HXS64_RS12685 ENOG4105BZU Histidine kinase HXS64_RS12690 ENOG4108UQS dipeptidase HXS64_RS12695 ENOG4105DEF Extracellular solute-binding protein, family 5 HXS64_RS12700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HXS64_RS12705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HXS64_RS12710 ENOG4105C3U ABC transporter HXS64_RS12715 ENOG4107H6U ABC transporter HXS64_RS12720 ENOG4108Z9K Osmotically inducible protein HXS64_RS12725 ENOG4105TPS biofilm-dependent modulation protein HXS64_RS12730 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HXS64_RS12735 ENOG4107R1I NAD-dependent malic enzyme HXS64_RS12740 ENOG4105DQ4 alcohol dehydrogenase HXS64_RS12745 ENOG41084S7 Plasmid maintenance system antidote protein HXS64_RS12750 ENOG4108MG3 formate dehydrogenase HXS64_RS12755 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HXS64_RS12765 ENOG4105RPH Inner membrane protein YddG HXS64_RS12780 ENOG4107QND Nitrite extrusion protein HXS64_RS12785 ENOG4105CRU nitrate reductase, alpha subunit HXS64_RS12790 ENOG4108IUE nitrate reductase beta subunit HXS64_RS12795 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HXS64_RS12800 ENOG4105D0D Nitrate reductase 2, gamma subunit HXS64_RS12805 ENOG4105JAB phenazine biosynthesis protein, phzf family HXS64_RS12810 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HXS64_RS12815 ENOG4108MEJ flavin reductase domain protein HXS64_RS12820 ENOG4105KZK Tautomerase pptA HXS64_RS12845 ENOG4105C85 amino acid HXS64_RS12850 ENOG4108NS2 receptor HXS64_RS12855 ENOG4105CHB tonB-dependent Receptor HXS64_RS12860 ENOG4108WYP Transcriptional regulator HXS64_RS12865 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HXS64_RS12870 ENOG4108Z7F N-acetyltransferase HXS64_RS12875 ENOG4108T9Y Inner membrane protein ydcZ HXS64_RS12880 ENOG4105R71 cytoplasmic protein HXS64_RS12885 ENOG410654E Membrane HXS64_RS12900 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HXS64_RS12905 ENOG4105D81 ABC transporter, permease HXS64_RS12910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HXS64_RS12915 ENOG4107TYH extracellular solute-binding protein family 1 HXS64_RS12920 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HXS64_RS12925 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HXS64_RS12935 ENOG4105RR0 Protein of unknown function (DUF2554) HXS64_RS12940 ENOG4105CFP Peptidase U32 HXS64_RS12945 ENOG4108JCI Transcriptional regulator HXS64_RS12950 ENOG4105DKK Benzoate HXS64_RS12965 ENOG4108KKZ (LipO)protein HXS64_RS12970 ENOG41088CC tellurite resistance protein tehB HXS64_RS12975 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HXS64_RS12980 ENOG4107WE3 acetyltransferase YdcK HXS64_RS12985 ENOG4108Z9I -acetyltransferase HXS64_RS12990 ENOG4105Z2P Protein of unknown function (DUF465) HXS64_RS13000 ENOG4105E32 cytoplasmic protein HXS64_RS13005 ENOG4105DDW LysR family Transcriptional regulator HXS64_RS13010 ENOG4105C8Q Methyl-accepting chemotaxis HXS64_RS13015 ENOG4107NK6 Hok/gef family HXS64_RS13020 ENOG4105UPP uncharacterized protein ydcA HXS64_RS13025 ENOG4105CPW cytochrome b561 HXS64_RS13030 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HXS64_RS13035 ENOG4105C26 Dehydrogenase HXS64_RS13040 ENOG4107DB1 DUF218 domain HXS64_RS13045 ENOG4105CQ7 ATP-dependent helicase HXS64_RS13055 ENOG41077RS Phosphatase HXS64_RS13060 ENOG4105E8V Alpha Beta Hydrolase Fold protein HXS64_RS13070 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HXS64_RS13080 ENOG4107S5I aldo keto reductase HXS64_RS13085 ENOG4107EF2 surface-exposed virulence protein HXS64_RS13095 ENOG4108Z0R Transferase HXS64_RS13100 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HXS64_RS13105 ENOG4105DZS Phenylacetate-CoA ligase HXS64_RS13110 ENOG4105CHU acetyl-coa acetyltransferase HXS64_RS13115 ENOG4108ZJI phenylacetic acid degradation protein HXS64_RS13120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HXS64_RS13125 ENOG4108UKI Enoyl-CoA hydratase HXS64_RS13130 ENOG4105E39 Enoyl-CoA hydratase HXS64_RS13135 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HXS64_RS13140 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HXS64_RS13145 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HXS64_RS13150 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HXS64_RS13155 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HXS64_RS13160 ENOG4105DXM phenylacetic acid degradation protein HXS64_RS13165 ENOG4105F11 amine oxidase HXS64_RS13170 ENOG4105C26 Dehydrogenase HXS64_RS13175 ENOG4108WFR AraC Family Transcriptional Regulator HXS64_RS13180 ENOG4105WXT Conserved Protein HXS64_RS13185 ENOG410689M (LipO)protein HXS64_RS13190 ENOG4107H52 Dicarboxylate transport HXS64_RS13195 ENOG4105C5I Dehydrogenase HXS64_RS13200 ENOG41090X5 Heat shock protein hslJ HXS64_RS13205 ENOG4105IKK cytoplasmic protein HXS64_RS13210 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HXS64_RS13215 ENOG4105FCK Membrane HXS64_RS13220 ENOG4108RW8 Universal stress protein F HXS64_RS13230 ENOG4105C1J atp-dependent rna helicase HXS64_RS13240 ENOG4105BZU Histidine kinase HXS64_RS13245 ENOG4108DG9 Smr protein MutS2 HXS64_RS13250 ENOG4106KR7 LysR family Transcriptional regulator HXS64_RS13255 ENOG4105CH2 amidohydrolase HXS64_RS13260 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HXS64_RS13265 ENOG4105CFC Transporter HXS64_RS13270 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HXS64_RS13275 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HXS64_RS13280 ENOG4105Q9Y Universal stress protein HXS64_RS13285 ENOG4105S5I Membrane HXS64_RS13290 ENOG4105D64 Mechanosensitive ion channel HXS64_RS13295 ENOG4107QSI ABC, transporter HXS64_RS13300 ENOG4105EQ2 LysR family Transcriptional regulator HXS64_RS13305 ENOG4105ENX hydrolase HXS64_RS13320 ENOG4105KXI murein peptide amidase A HXS64_RS13325 ENOG4107S8C mandelate racemase muconate lactonizing HXS64_RS13330 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HXS64_RS13335 ENOG4108JU8 Transcriptional regulator HXS64_RS13345 ENOG4105CM6 amino acid regulated cytosolic protein HXS64_RS13350 ENOG4105FKQ transcriptional regulator HXS64_RS13355 ENOG4107EFV Outer membrane protein G HXS64_RS13360 ENOG4108IJ9 (ABC) transporter HXS64_RS13365 ENOG4107URF beta-phospho-glucomutase HXS64_RS13370 ENOG4105C71 hydrolase family 65, central catalytic HXS64_RS13375 ENOG4105CK5 oxidoreductase HXS64_RS13380 ENOG4107TYA transient receptor potential locus HXS64_RS13390 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HXS64_RS13395 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HXS64_RS13400 ENOG4105WEM extracellular solute-binding protein HXS64_RS13405 ENOG4107QW3 Sucrose phosphorylase HXS64_RS13410 ENOG4107QW3 Sucrose phosphorylase HXS64_RS13415 ENOG4105K8Z Phage shock protein HXS64_RS13420 ENOG4105NNG Peripheral inner membrane phage-shock protein HXS64_RS13425 ENOG4105FM1 phage shock protein C HXS64_RS13430 ENOG4105YYT phage shock protein B HXS64_RS13435 ENOG41087YS Phage shock protein A HXS64_RS13440 ENOG4105E51 psp operon transcriptional activator HXS64_RS13445 ENOG4108JPW Aminotransferase HXS64_RS13450 ENOG4105CJP fad dependent oxidoreductase HXS64_RS13455 ENOG4105C26 Dehydrogenase HXS64_RS13460 ENOG4107VRI Transcriptional regulator HXS64_RS13465 ENOG4108Z86 Glutamine amidotransferase HXS64_RS13470 ENOG4105CFQ glutamine synthetase HXS64_RS13480 ENOG4105CUB amino acid HXS64_RS13485 ENOG4105N0E Protein of unknown function (DUF2543) HXS64_RS13490 ENOG4108HIY periplasmic HXS64_RS13495 ENOG4108I5W peptide transport system, permease protein HXS64_RS13500 ENOG4108EU3 peptide transport system, permease HXS64_RS13505 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HXS64_RS13510 ENOG4108JQ2 peptide transport system atp-binding protein HXS64_RS13515 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HXS64_RS13520 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HXS64_RS13525 ENOG4105Q4T oxidoreductase HXS64_RS13540 ENOG4105BZU Histidine kinase HXS64_RS13545 ENOG410643D UPF0509 protein HXS64_RS13550 ENOG4105N2W Transcriptional regulator HXS64_RS13560 ENOG4108ZJT translation initiation factor, Sui1 HXS64_RS13565 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HXS64_RS13570 ENOG4105CFV Tetratricopeptide repeat protein HXS64_RS13575 ENOG4105Q4A inner membrane protein yciS HXS64_RS13580 ENOG4105EYK Phosphatidylglycerophosphatase B HXS64_RS13590 ENOG4107QM5 aconitate hydratase HXS64_RS13615 ENOG4107R11 Transcriptional regulator HXS64_RS13620 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HXS64_RS13625 ENOG4105RKX Protein of unknown function (DUF2498) HXS64_RS13630 ENOG4105ERU peptidase HXS64_RS13635 ENOG4105UBK short-chain dehydrogenase reductase HXS64_RS13640 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HXS64_RS13645 ENOG4105FE9 pseudouridine synthase HXS64_RS13650 ENOG4105EG3 transmembrane signal peptide protein HXS64_RS13655 ENOG4107RTD sua5 ycio yrdc ywlc family protein HXS64_RS13660 ENOG4105DB7 PHP domain protein HXS64_RS13670 ENOG4105CRQ synthase (Component I) HXS64_RS13675 ENOG4108EFP Anthranilate synthase component II HXS64_RS13680 ENOG4105DK0 Indole-3-glycerol phosphate synthase HXS64_RS13700 ENOG4108Z9Z response to DNA damage stimulus HXS64_RS13705 ENOG4108N8X transition metal ion binding HXS64_RS13710 ENOG4105EIF outer membrane protein W HXS64_RS13720 ENOG4108S3I UPF0259 membrane protein HXS64_RS13730 ENOG4105NAU thioesterase Superfamily protein HXS64_RS13735 ENOG410822N TonB family HXS64_RS13740 ENOG4105K9H YciI-like protein HXS64_RS13745 ENOG4107SVH Potassium channel protein HXS64_RS13765 ENOG4108JQ7 (ABC) transporter HXS64_RS13770 ENOG4105C3U ABC transporter HXS64_RS13775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HXS64_RS13780 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HXS64_RS13785 ENOG4108J59 Extracellular solute-binding protein, family 5 HXS64_RS13795 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HXS64_RS13800 ENOG4105C0A alcohol dehydrogenase HXS64_RS13805 ENOG4107104 thymidine kinase HXS64_RS13810 ENOG4108SAU DNA-binding protein H-ns HXS64_RS13815 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HXS64_RS13820 ENOG4105I93 response regulator HXS64_RS13825 ENOG4105D78 K07001 NTE family protein HXS64_RS13835 ENOG4105CIY formyltetrahydrofolate deformylase HXS64_RS13865 ENOG41076YT nitrate reductase, gamma subunit HXS64_RS13870 ENOG4105R3A Nitrate reductase HXS64_RS13875 ENOG4108IUE nitrate reductase beta subunit HXS64_RS13880 ENOG4105CRU nitrate reductase, alpha subunit HXS64_RS13885 ENOG4105DQQ Major facilitator superfamily MFS_1 HXS64_RS13890 ENOG4105BZU Histidine kinase HXS64_RS13895 ENOG4105WH1 Two component transcriptional regulator luxr family HXS64_RS13900 ENOG4105ID0 Putative invasin HXS64_RS13905 ENOG41090EX DsrE family HXS64_RS13910 ENOG4108NH8 Cation transport protein HXS64_RS13915 ENOG4105WS7 Cation transport regulator HXS64_RS13920 ENOG4105EWV Sodium calcium exchanger membrane region HXS64_RS13945 ENOG41063JG Transcriptional regulator HXS64_RS13950 ENOG4108YY7 Invasion gene expression up-regulator SirB HXS64_RS13955 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HXS64_RS13965 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HXS64_RS13975 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HXS64_RS13980 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HXS64_RS13985 ENOG4105CHH sulfate transporter HXS64_RS13990 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HXS64_RS14000 ENOG4105C3G gtp-binding protein HXS64_RS14005 ENOG4105I1J Autotransporter HXS64_RS14010 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HXS64_RS14015 ENOG4105CMT Dihydroxyacetone kinase HXS64_RS14020 ENOG4108UTZ Dihydroxyacetone kinase HXS64_RS14025 ENOG4105VDH Dihydroxyacetone kinase HXS64_RS14040 ENOG4105Y3U Transglycosylase-associated protein HXS64_RS14045 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HXS64_RS14050 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HXS64_RS14055 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HXS64_RS14065 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HXS64_RS14075 ENOG4105ED1 spovr family HXS64_RS14090 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HXS64_RS14095 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HXS64_RS14100 ENOG4105KT5 UmuD protein HXS64_RS14105 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HXS64_RS14115 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HXS64_RS14125 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HXS64_RS14130 ENOG4105S66 prophage protein HXS64_RS14140 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HXS64_RS14145 ENOG4107QMS site-determining protein HXS64_RS14180 ENOG410658X HXS64_RS14210 ENOG4108XDN Transcriptional regulator HXS64_RS14215 ENOG41064WM Uncharacterized protein YcgX HXS64_RS14230 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) HXS64_RS14235 ENOG4108HMX isocitrate dehydrogenase (NADP) HXS64_RS14240 ENOG4108R99 pseudouridine synthase HXS64_RS14260 ENOG4107QTF adenylosuccinate lyase HXS64_RS14265 ENOG4105XJC Two component transcriptional regulator (Winged helix family HXS64_RS14270 ENOG4105IFJ Histidine kinase HXS64_RS14275 ENOG4105EZE Cupin 4 family protein HXS64_RS14280 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HXS64_RS14285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HXS64_RS14295 ENOG4105D38 putrescine abc transporter HXS64_RS14300 ENOG4107RUE extracellular solute-binding protein family 1 HXS64_RS14315 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HXS64_RS14325 ENOG4105D60 lipoprotein releasing system transmembrane protein HXS64_RS14330 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HXS64_RS14335 ENOG4105D60 lipoprotein releasing system transmembrane protein HXS64_RS14340 ENOG4105IQC Inner membrane protein YcfT HXS64_RS14345 ENOG4108JA2 transcriptioN-repair coupling factor HXS64_RS14350 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HXS64_RS14355 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HXS64_RS14360 ENOG4108IND Tetr family transcriptional regulator HXS64_RS14365 ENOG4107MBR 17 kDa surface antigen HXS64_RS14370 ENOG4105CEP NADH dehydrogenase HXS64_RS14380 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HXS64_RS14385 ENOG4108RUM thiamine kinase HXS64_RS14390 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HXS64_RS14395 ENOG41090DQ Lipoprotein HXS64_RS14400 ENOG4105K59 histidine triad (HIT) protein HXS64_RS14405 ENOG4105CNM Receptor HXS64_RS14410 ENOG4105CI1 PTS System HXS64_RS14415 ENOG4105F8V Hydrolase, tatD family HXS64_RS14420 ENOG4107QRG dna polymerase iii HXS64_RS14430 ENOG4105HHA aminodeoxychorismate lyase HXS64_RS14435 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HXS64_RS14440 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HXS64_RS14445 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HXS64_RS14450 ENOG4105CHR reductase HXS64_RS14455 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HXS64_RS14475 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HXS64_RS14480 ENOG4108UHJ MAF-like protein HXS64_RS14485 ENOG4105EI2 Pseudouridine synthase HXS64_RS14490 ENOG4107QQB Ribonuclease E HXS64_RS14495 ENOG4105DTJ flagellar hook-associated protein HXS64_RS14500 ENOG4105E1Q flagellar hook-associated protein HXS64_RS14505 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HXS64_RS14520 ENOG4105CGA flagellar basal-body rod protein FlgG HXS64_RS14525 ENOG4108KPB Flagellar basal-body rod protein FlgF HXS64_RS14530 ENOG4105BZE flagellar hook protein, FlgE HXS64_RS14535 ENOG4105W00 Flagellar hook capping protein HXS64_RS14540 ENOG4108ZC9 flagellar basal-body rod protein flgc HXS64_RS14545 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HXS64_RS14550 ENOG4105CKS Flagella basal body P-ring formation protein flgA HXS64_RS14555 ENOG4105M9M anti-sigma28 factor FlgM HXS64_RS14560 ENOG4105QVD Flagella synthesis protein FlgN HXS64_RS14565 ENOG4105CJR Integral membrane protein (MviN HXS64_RS14570 ENOG4105EP9 oxidoreductase HXS64_RS14575 ENOG4108YXG UPF0502 protein HXS64_RS14580 ENOG4105D9U N-acetyltransferase HXS64_RS14590 ENOG4105E9S glutaredoxin 2 HXS64_RS14595 ENOG4105F3T (LipO)protein HXS64_RS14600 ENOG4105EKE dihydroorotase HXS64_RS14605 ENOG4105MEA DNA damage-inducible protein i HXS64_RS14610 ENOG4105PVA Biofilm formation regulatory protein BssS HXS64_RS14615 ENOG4105F76 Sarcosine oxidase HXS64_RS14620 ENOG4106974 biofilm formation HXS64_RS14625 ENOG4105DS1 cytochrome b561 HXS64_RS14630 ENOG4108YYC ycei family HXS64_RS14635 ENOG4105C72 UPF0176 protein HXS64_RS14640 ENOG4105D1S lipid A biosynthesis HXS64_RS14650 ENOG4108W47 Acidic protein msyB HXS64_RS14655 ENOG4105NAC (LipO)protein HXS64_RS14660 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HXS64_RS14665 ENOG4105DJ9 glucan biosynthesis protein HXS64_RS14670 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HXS64_RS14675 ENOG4107RZC phospholipase d HXS64_RS14680 ENOG4108UVJ appr-1-p processing domain protein HXS64_RS14690 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HXS64_RS14695 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HXS64_RS14700 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HXS64_RS14705 ENOG41086KC Transcriptional regulator HXS64_RS14710 ENOG4108XDW curli assembly protein CsgE HXS64_RS14715 ENOG4108WYR Curli production assembly transport component, CsgF HXS64_RS14720 ENOG4105P8Q Curli production assembly transport component CsgG HXS64_RS14725 ENOG4108UQ5 membrane protein YcdZ HXS64_RS14730 ENOG4107XHZ cytoplasmic chaperone TorD family protein HXS64_RS14735 ENOG4107SSZ Phosphatase HXS64_RS14740 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HXS64_RS14755 ENOG4108T85 Membrane HXS64_RS14770 ENOG4105BZU Histidine kinase HXS64_RS14780 ENOG4107BJW polysaccharide deacetylase HXS64_RS14790 ENOG4105CND Glycosyl transferase, family 2 HXS64_RS14800 ENOG4105D5M phosphate starvation-inducible protein HXS64_RS14805 ENOG4105DBE peroxidase HXS64_RS14810 ENOG410650H (LipO)protein HXS64_RS14820 ENOG4105CK7 Sodium proline symporter HXS64_RS14830 ENOG4105C26 Dehydrogenase HXS64_RS14835 ENOG4108R86 Transcriptional regulator HXS64_RS14840 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HXS64_RS14845 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HXS64_RS14855 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HXS64_RS14860 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HXS64_RS14865 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HXS64_RS14870 ENOG4105C2W permease HXS64_RS14875 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HXS64_RS14885 ENOG4105XH3 HXS64_RS14910 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HXS64_RS14915 ENOG4107QY8 reductase HXS64_RS14920 ENOG4105CUW cytochrome C-TYPE protein HXS64_RS14925 ENOG4106WF9 DNA-binding transcriptional regulator TorR HXS64_RS14930 ENOG4108SV3 Tmao reductase system periplasmic protein tort HXS64_RS14935 ENOG4105BZU Histidine kinase HXS64_RS14940 ENOG4105HEE Binding Domain protein HXS64_RS14945 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HXS64_RS14960 ENOG4105VEQ Cold shock protein HXS64_RS14965 ENOG41060EU Cold shock-like protein HXS64_RS14980 ENOG4108Y9B (LipO)protein HXS64_RS14985 ENOG4108W78 Pfam:DUF1017 HXS64_RS14990 ENOG4105E3R (LipO)protein HXS64_RS14995 ENOG4105DAY polysaccharide export protein HXS64_RS15000 ENOG4107ZF2 Phosphatase HXS64_RS15005 ENOG4105D75 Capsular exopolysaccharide family HXS64_RS15010 ENOG4105D6F Phosphatase HXS64_RS15020 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HXS64_RS15025 ENOG4105C4M (Ubiquinol oxidase) subunit I HXS64_RS15030 ENOG4105MVP hydrogenase-1 operon protein HyaF HXS64_RS15035 ENOG4108VXY Hydrogenase-1 operon protein HyaE HXS64_RS15040 ENOG4108USZ hydrogenase HXS64_RS15045 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HXS64_RS15050 ENOG4105DPX Hydrogenase, large subunit HXS64_RS15055 ENOG4105E3S small subunit HXS64_RS15065 ENOG4108MN8 Membrane HXS64_RS15070 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HXS64_RS15075 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HXS64_RS15090 ENOG4105K4P CoA-binding domain protein HXS64_RS15105 ENOG41088T4 Helicase IV HXS64_RS15110 ENOG410901E Membrane HXS64_RS15115 ENOG4105EM2 membrane HXS64_RS15120 ENOG4108RZ1 DNA transformation protein HXS64_RS15130 ENOG4105UYK outer membrane protein a HXS64_RS15140 ENOG4105DAN ATP-dependent protease HXS64_RS15150 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HXS64_RS15155 ENOG4108Q2G (LipO)protein HXS64_RS15160 ENOG4105DY2 Paraquat-inducible protein b HXS64_RS15165 ENOG4105F1S paraquat-inducible protein a HXS64_RS15170 ENOG4105C5H ABC transporter HXS64_RS15180 ENOG4105QVC MOSC domain-containing protein HXS64_RS15185 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HXS64_RS15195 ENOG4106PH7 chaperone HXS64_RS15200 ENOG4105MX3 Fimbrial HXS64_RS15205 ENOG4105Q7J Fimbrial HXS64_RS15210 ENOG4108MDY Fimbrial HXS64_RS15215 ENOG4105CW0 outer membrane usher protein HXS64_RS15220 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HXS64_RS15225 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HXS64_RS15230 ENOG4108UZX fmn reductase HXS64_RS15235 ENOG4105GVF (ABC) transporter HXS64_RS15245 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HXS64_RS15250 ENOG4105E2Y ABC, transporter HXS64_RS15255 ENOG4105CD8 aminopeptidase N HXS64_RS15260 ENOG4107RH7 Nicotinate phosphoribosyltransferase HXS64_RS15270 ENOG4105FCK Membrane HXS64_RS15275 ENOG4105CGF Aromatic amino acid aminotransferase HXS64_RS15280 ENOG4105C5X domain protein HXS64_RS15285 ENOG4105EAQ (twin-arginine translocation) pathway signal HXS64_RS15290 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HXS64_RS15295 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HXS64_RS15300 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HXS64_RS15310 ENOG4106371 Methyltransferase HXS64_RS15315 ENOG4107S90 membrAne HXS64_RS15320 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HXS64_RS15335 ENOG4105T0Z Conserved Protein HXS64_RS15340 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HXS64_RS15345 ENOG4105BZ1 (ABC) transporter HXS64_RS15350 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HXS64_RS15360 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HXS64_RS15370 ENOG4108K0D peptidase, M48 HXS64_RS15380 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HXS64_RS15385 ENOG4107VMU Membrane HXS64_RS15390 ENOG4105DDY UPF0142 protein ycaO HXS64_RS15395 ENOG4105TMB Formate nitrite transporter HXS64_RS15400 ENOG4105C6N Formate acetyltransferase HXS64_RS15405 ENOG4105F1A Pyruvate formate-lyase HXS64_RS15410 ENOG4108X0B nad(p)h dehydrogenase (quinone) HXS64_RS15415 ENOG410642W LysR family Transcriptional regulator HXS64_RS15420 ENOG4105E5D amino acid HXS64_RS15430 ENOG4105CHJ isochorismatase hydrolase HXS64_RS15435 ENOG4107KGK dmso reductase anchor subunit HXS64_RS15440 ENOG4105QAX Iron-sulfur HXS64_RS15445 ENOG4107QY8 reductase HXS64_RS15455 ENOG4105D1H recombination factor protein RarA HXS64_RS15465 ENOG4105CNU cell division protein FtsK HXS64_RS15475 ENOG4105C3M thioredoxin reductase HXS64_RS15480 ENOG4108JJ9 ABC, transporter HXS64_RS15485 ENOG4108JJ8 (ABC) transporter HXS64_RS15495 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HXS64_RS15510 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HXS64_RS15520 ENOG4105VEQ Cold shock protein HXS64_RS15525 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HXS64_RS15530 ENOG4105DJY efflux transporter, rnd family, mfp subunit HXS64_RS15535 ENOG4108MJ5 VirK protein HXS64_RS15540 ENOG4105CPB ATP-dependent endonuclease of the OLD family HXS64_RS15545 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HXS64_RS15550 ENOG4105DWU Membrane HXS64_RS15560 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HXS64_RS15565 ENOG4105C7K acetolactate synthase HXS64_RS15570 ENOG4105C5W Aldolase HXS64_RS15575 ENOG4105CGD Nad-dependent epimerase dehydratase HXS64_RS15580 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HXS64_RS15585 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HXS64_RS15595 ENOG41064MM (LipO)protein HXS64_RS15600 ENOG4105E5Z arginine transporter ATP-binding subunit HXS64_RS15605 ENOG4106PMH Extracellular solute-binding protein family 3 HXS64_RS15610 ENOG4105GBT ABC transporter HXS64_RS15615 ENOG4105DMR ABC, transporter HXS64_RS15620 ENOG4106TNF Periplasmic binding protein HXS64_RS15625 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HXS64_RS15630 ENOG4105RBQ inner membrane protein ybjO HXS64_RS15635 ENOG4105D38 putrescine abc transporter HXS64_RS15640 ENOG4105F38 ABC transporter, permease HXS64_RS15645 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HXS64_RS15650 ENOG4107RUE extracellular solute-binding protein family 1 HXS64_RS15655 ENOG4108RMJ sensory transduction regulator HXS64_RS15665 ENOG4108DBC nitroreductase HXS64_RS15670 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HXS64_RS15675 ENOG41090BQ Glutaredoxin HXS64_RS15680 ENOG4105GWF inner membrane protein YbjM HXS64_RS15690 ENOG4108RFG Tetr family transcriptional regulator HXS64_RS15695 ENOG4106UW1 Major Facilitator superfamily HXS64_RS15720 ENOG4107QF7 multi-drug HXS64_RS15725 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HXS64_RS15730 ENOG4107FB0 transcriptional regulator DeoR family HXS64_RS15735 ENOG4105DZ1 carboxypeptidase HXS64_RS15740 ENOG4108TGY Glutathione S-transferase HXS64_RS15745 ENOG4105D8V Glucose sorbosone dehydrogenase HXS64_RS15750 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HXS64_RS15760 ENOG41064RH membrane protein YliF HXS64_RS15765 ENOG4105BZU Histidine kinase HXS64_RS15770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HXS64_RS15780 ENOG4105DEF Extracellular solute-binding protein, family 5 HXS64_RS15785 ENOG4108JQ6 ABC transporter HXS64_RS15790 ENOG4105D44 asparaginase HXS64_RS15795 ENOG4105CVM Molybdenum cofactor synthesis domain protein HXS64_RS15800 ENOG4105D06 uba thif-type nad fad binding protein HXS64_RS15805 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HXS64_RS15810 ENOG4105F1A Pyruvate formate-lyase HXS64_RS15820 ENOG4108HCJ Hydrolase HXS64_RS15825 ENOG41072TH Protein of unknown function (DUF1479) HXS64_RS15830 ENOG4105C5H ABC transporter HXS64_RS15835 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HXS64_RS15840 ENOG4105F4P )-transporter HXS64_RS15845 ENOG4105KST dependent repressor HXS64_RS15855 ENOG4108I6E Sulfatase HXS64_RS15860 ENOG4108T1M outer membrane protein x HXS64_RS15870 ENOG4107AQZ Membrane HXS64_RS15880 ENOG4107R0W ABC transporter HXS64_RS15885 ENOG4105E5Q amino acid AbC transporter HXS64_RS15890 ENOG4105CDA abc transporter atp-binding protein HXS64_RS15895 ENOG4105D8X mechanosensitive ion channel HXS64_RS15905 ENOG4105ZY9 UPF0379 protein ybiM HXS64_RS15910 ENOG4108IU3 tonb-dependent siderophore receptor HXS64_RS15920 ENOG4105KSC Transcriptional regulator, TraR DksA family HXS64_RS15925 ENOG4105VR4 UPF0379 protein ybiJ HXS64_RS15930 ENOG4105DG4 malate L-lactate dehydrogenase HXS64_RS15935 ENOG4108MTB glycosyl transferase family HXS64_RS15940 ENOG4105DVT helicase HXS64_RS15945 ENOG4108UV1 cellular component movement HXS64_RS15950 ENOG4105C1J atp-dependent rna helicase HXS64_RS15955 ENOG4107MVR Transcriptional regulator HXS64_RS15965 ENOG4105CJ1 ABC, transporter HXS64_RS15970 ENOG4107QWP ABC-2 type transporter HXS64_RS15975 ENOG4107QWP ABC-2 type transporter HXS64_RS15980 ENOG4105I9U inner membrane protein ybhQ HXS64_RS15985 ENOG4105X23 Endonuclease Exonuclease phosphatase HXS64_RS15990 ENOG4105DZQ phospholipase D Transphosphatidylase HXS64_RS15995 ENOG4107UXM Membrane HXS64_RS16000 ENOG410733J conserved inner membrane protein HXS64_RS16005 ENOG4105HFZ Membrane HXS64_RS16010 ENOG4108ZAF Molybdopterin HXS64_RS16015 ENOG4105M00 molybdopterin converting factor, subunit 1 HXS64_RS16025 ENOG4108RIR Molybdenum cofactor biosynthesis protein HXS64_RS16035 ENOG4105CHW UPF0052 protein HXS64_RS16045 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HXS64_RS16050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HXS64_RS16055 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HXS64_RS16065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HXS64_RS16070 ENOG4108V1U phospholipid-binding protein HXS64_RS16075 ENOG4106KTS Inner membrane protein yeaI HXS64_RS16090 ENOG4108C33 Resolvase HXS64_RS16100 ENOG4105UZW Tail fiber assembly protein HXS64_RS16110 ENOG4108X9F tail fiber protein HXS64_RS16235 ENOG4108ES9 ParB domain protein nuclease HXS64_RS16240 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HXS64_RS16250 ENOG4105KUS lysozyme HXS64_RS16280 ENOG4108I1J Integrase HXS64_RS16285 ENOG4105NBR Pectinesterase HXS64_RS16290 ENOG4107QM5 aconitate hydratase HXS64_RS16305 ENOG4108K4B hydrolase HXS64_RS16310 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HXS64_RS16315 ENOG4105E0C molybdate abc transporter HXS64_RS16320 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HXS64_RS16330 ENOG4105F4R Transcriptional regulator mode HXS64_RS16335 ENOG4105DKW ABC transporter HXS64_RS16340 ENOG4105CMR udp-glucose 4-epimerase HXS64_RS16345 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HXS64_RS16355 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HXS64_RS16365 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HXS64_RS16370 ENOG4105JND homeobox protein HXS64_RS16375 ENOG4105PGM cation diffusion facilitator family transporter HXS64_RS16380 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HXS64_RS16385 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HXS64_RS16425 ENOG4105UFD tol-pal system protein YbgF HXS64_RS16430 ENOG4105KCK Peptidoglycan-associated lipoprotein HXS64_RS16440 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HXS64_RS16450 ENOG4105E02 MotA TolQ exbB proton channel HXS64_RS16455 ENOG4107YD3 Thioesterase HXS64_RS16460 ENOG4105KJB cyd operon protein YbgE HXS64_RS16470 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HXS64_RS16475 ENOG4105C4M (Ubiquinol oxidase) subunit I HXS64_RS16480 ENOG4105C8I hydrolase, family 38 HXS64_RS16485 ENOG4105DM4 PTS System HXS64_RS16490 ENOG4105FDP GntR family transcriptional regulator HXS64_RS16495 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HXS64_RS16505 ENOG4105C7S Dehydrogenase HXS64_RS16510 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HXS64_RS16515 ENOG4105E33 succinate dehydrogenase HXS64_RS16520 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HXS64_RS16525 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HXS64_RS16530 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HXS64_RS16540 ENOG4105BZN citrate synthase HXS64_RS16545 ENOG4106UBK fimbrial-like adhesin protein HXS64_RS16550 ENOG4106PG1 outer membrane usher protein HXS64_RS16555 ENOG4108TTM chaperone HXS64_RS16560 ENOG4108MY7 Fimbrial HXS64_RS16565 ENOG4108KK1 membrane protein AbrB duplication HXS64_RS16575 ENOG4105E7W lamb ycsf family protein HXS64_RS16580 ENOG4107R7A Allophanate hydrolase subunit 2 HXS64_RS16585 ENOG4105P4J Allophanate hydrolase, subunit 1 HXS64_RS16590 ENOG4107QNR UPF0135 protein HXS64_RS16595 ENOG4105DUX Transporter HXS64_RS16600 ENOG4105CVP deoxyribo-dipyrimidine photolyase HXS64_RS16605 ENOG4107SEY Conserved Protein HXS64_RS16625 ENOG4105XIQ Protein of unknown function (DUF2517) HXS64_RS16640 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HXS64_RS16645 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HXS64_RS16650 ENOG4105C08 Histidine kinase HXS64_RS16655 ENOG4105EEX Two component transcriptional regulator (Winged helix family HXS64_RS16680 ENOG4105D5Q Arginine ornithine antiporter HXS64_RS16705 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HXS64_RS16710 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HXS64_RS16715 ENOG4105EV9 Alpha Beta Hydrolase HXS64_RS16720 ENOG4105NNH LexA regulated protein HXS64_RS16725 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HXS64_RS16735 ENOG41090R7 Ferric uptake HXS64_RS16740 ENOG4105GX6 (LipO)protein HXS64_RS16755 ENOG4105CI1 PTS System HXS64_RS16765 ENOG4105CE4 GlcNAc 6-P deacetylase HXS64_RS16770 ENOG4105E2R ROK family HXS64_RS16775 ENOG4105D4U had-superfamily hydrolase, subfamily iia HXS64_RS16780 ENOG4105CAQ asparagine synthetase HXS64_RS16820 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HXS64_RS16830 ENOG4105C9A Phoh family HXS64_RS16840 ENOG4108JU5 Magnesium and cobalt efflux protein HXS64_RS16845 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HXS64_RS16850 ENOG4107RP9 extracellular solute-binding protein, family 3 HXS64_RS16855 ENOG4105EAD ABC transporter HXS64_RS16860 ENOG4105DRP amino acid AbC transporter HXS64_RS16865 ENOG4105CDA abc transporter atp-binding protein HXS64_RS16890 ENOG4105QFC Hsc56 co-chaperone of HscC HXS64_RS16895 ENOG41069CF Protein of unknown function (DUF1266) HXS64_RS16900 ENOG4105EUU Sel1 domain protein repeat-containing protein HXS64_RS16905 ENOG4107PAI alpha helical protein HXS64_RS16920 ENOG4105DJF DNA polymerase III, delta' subunit HXS64_RS16930 ENOG4108TGR phosphatase HXS64_RS16935 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HXS64_RS16945 ENOG4105CJN penicillin-binding protein HXS64_RS16950 ENOG4105CNI cell division protein FtsW HXS64_RS16955 ENOG4105K6T rare lipoprotein A HXS64_RS16960 ENOG4105DZ1 carboxypeptidase HXS64_RS16975 ENOG41064T2 transcriptional regulator, lysR family HXS64_RS16985 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HXS64_RS17020 ENOG4105CEE C4-dicarboxylate transporter HXS64_RS17025 ENOG4106YYS transcriptional regulatory protein HXS64_RS17030 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HXS64_RS17035 ENOG4105DUA (citrate (pro-3S)-lyase ligase HXS64_RS17045 ENOG4105CI0 Citrate lyase HXS64_RS17050 ENOG4105CHY citrate lyase, alpha HXS64_RS17065 ENOG4107QPK )-transporter HXS64_RS17070 ENOG4105KTS ribonuclease HXS64_RS17075 ENOG4105NXH GreA GreB family elongation factor HXS64_RS17080 ENOG4105E2A Dehydrogenase HXS64_RS17085 ENOG4108U51 Universal stress protein HXS64_RS17090 ENOG4108JU3 Alkyl hydroperoxide reductase HXS64_RS17095 ENOG4105D3R alkyl hydroperoxide reductase HXS64_RS17100 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HXS64_RS17105 ENOG4105DQS Transcriptional regulator HXS64_RS17110 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HXS64_RS17115 ENOG4105GTN ParB Domain Protein Nuclease HXS64_RS17120 ENOG4105CHM Aminotransferase HXS64_RS17125 ENOG4107SCQ Iron-containing alcohol dehydrogenase HXS64_RS17130 ENOG4105VCD cytoplasmic protein HXS64_RS17135 ENOG4105D22 carbon starvation protein HXS64_RS17140 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HXS64_RS17145 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HXS64_RS17150 ENOG4105WQI isochorismatase HXS64_RS17155 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HXS64_RS17160 ENOG4105E4F Isochorismate synthase HXS64_RS17165 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HXS64_RS17175 ENOG4105DQ5 transport system permease protein HXS64_RS17180 ENOG4105TVJ transport system, permease HXS64_RS17185 ENOG4105E0A ABC, transporter HXS64_RS17190 ENOG4108QY5 Ferric enterobactin transport protein HXS64_RS17195 ENOG4105C0W non-ribosomal peptide synthetase HXS64_RS17200 ENOG41085A6 mbth domain-containing protein HXS64_RS17205 ENOG4105E93 esterase HXS64_RS17210 ENOG4107RNH Outer membrane receptor FepA HXS64_RS17215 ENOG4108TSE Transferase HXS64_RS17225 ENOG4107635 Hok Gef family protein HXS64_RS17230 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HXS64_RS17235 ENOG4105WQ6 Membrane HXS64_RS17240 ENOG4105MSB protein, conserved in bacteria HXS64_RS17245 ENOG4108RCM Nitroreductase HXS64_RS17250 ENOG4105CUY Mechanosensitive ion channel HXS64_RS17255 ENOG4105C85 amino acid HXS64_RS17260 ENOG4108IJF Heavy metal efflux pump, CzcA HXS64_RS17265 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HXS64_RS17270 ENOG410624V efflux system protein HXS64_RS17275 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HXS64_RS17280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HXS64_RS17285 ENOG4105GR3 Histidine kinase HXS64_RS17290 ENOG4105CS6 Rhs element vgr protein HXS64_RS17300 ENOG4105CNA YD repeat protein HXS64_RS17305 ENOG4105CNA YD repeat protein HXS64_RS17320 ENOG410600T transposase HXS64_RS17335 ENOG4105QUW HXS64_RS17345 ENOG4108NC2 Outer membrane protease HXS64_RS17350 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HXS64_RS17390 ENOG4105F7J membrane-bound serine protease HXS64_RS17400 ENOG4107DE1 head-to-tail joining protein HXS64_RS17405 ENOG4105UZW Tail fiber assembly protein HXS64_RS17410 ENOG4105FKG DNA packaging protein HXS64_RS17415 ENOG4106YSC HXS64_RS17420 ENOG41064WM Uncharacterized protein YcgX HXS64_RS17430 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HXS64_RS17435 ENOG4105KUS lysozyme HXS64_RS17440 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HXS64_RS17450 ENOG4105HRS Antitermination protein HXS64_RS17455 ENOG4108MXB Protein of unknown function (DUF968) HXS64_RS17465 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HXS64_RS17495 ENOG4108S1U HXS64_RS17510 ENOG4105H40 HXS64_RS17515 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HXS64_RS17520 ENOG4108R7K Metal Dependent Phosphohydrolase HXS64_RS17525 ENOG41077V0 CPS-53 (KpLE1) prophage HXS64_RS17535 ENOG4108KU3 Integrase HXS64_RS17545 ENOG4108Q9V regulatoR HXS64_RS17550 ENOG4108ZI2 Fimbrial protein HXS64_RS17560 ENOG4105CW0 outer membrane usher protein HXS64_RS17565 ENOG4108AF8 Chaperone HXS64_RS17570 ENOG4108WDE Fimbrial protein HXS64_RS17575 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HXS64_RS17580 ENOG4105WQ3 Rna-binding protein HXS64_RS17585 ENOG4105S2T inner membrane protein YbcI HXS64_RS17595 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HXS64_RS17605 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HXS64_RS17610 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HXS64_RS17615 ENOG4105C5B carbamate kinase HXS64_RS17625 ENOG4107REC cytoplasmic protein HXS64_RS17630 ENOG4107R1Q Membrane protein FdrA HXS64_RS17635 ENOG4105DG4 malate L-lactate dehydrogenase HXS64_RS17640 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HXS64_RS17645 ENOG4105S0E allantoin catabolism protein HXS64_RS17650 ENOG4105BZW Glycerate kinase HXS64_RS17655 ENOG4105DTE Xanthine uracil vitamin C permease HXS64_RS17660 ENOG4105CD3 dihydroorotase HXS64_RS17665 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HXS64_RS17670 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HXS64_RS17675 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HXS64_RS17680 ENOG41060W2 glyoxylate carboligase HXS64_RS17685 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HXS64_RS17695 ENOG4107653 Transcriptional regulator HXS64_RS17700 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HXS64_RS17730 ENOG4105CNA YD repeat protein HXS64_RS17735 ENOG4105CV6 ABC transporter, permease HXS64_RS17740 ENOG4108I0Y (ABC) transporter HXS64_RS17745 ENOG4108UJV acyl-CoA thioesterase i HXS64_RS17750 ENOG4105E1F short-chain dehydrogenase reductase HXS64_RS17755 ENOG4107QR8 Thioredoxin HXS64_RS17760 ENOG4105C4B ABC transporter, permease HXS64_RS17765 ENOG41083J0 (ABC) transporter HXS64_RS17770 ENOG4107QX8 SPFH domain, Band 7 family protein HXS64_RS17775 ENOG4105G5H Membrane HXS64_RS17780 ENOG4108Z6Z Transcriptional regulator HXS64_RS17785 ENOG4107RY6 amino acid HXS64_RS17790 ENOG4105CSV Glutaminase HXS64_RS17795 ENOG4105C59 p-type ATPase HXS64_RS17800 ENOG41081XE plasmid maintenance system antidote protein, xre family HXS64_RS17805 ENOG4105MBR gumn family HXS64_RS17810 ENOG4108Z66 YbaK ebsC protein HXS64_RS17815 ENOG4105CGH 5'-nucleotidase HXS64_RS17820 ENOG4105EU0 Major facilitator Superfamily HXS64_RS17825 ENOG4105CKD glutathione-regulated potassium-efflux system protein HXS64_RS17830 ENOG4107RE1 Inosine-guanosine kinase HXS64_RS17865 ENOG4107QMP dna polymerase iii subunits gamma and tau HXS64_RS17875 ENOG4105WD1 Membrane HXS64_RS17880 ENOG4108URS primosomal replication protein n'' HXS64_RS17885 ENOG4106428 Protein of unknown function (DUF2496) HXS64_RS17890 ENOG4105EGS Mechanosensitive ion channel HXS64_RS17895 ENOG4107XI7 Tetr family transcriptional regulator HXS64_RS17900 ENOG4105C1P efflux transporter, rnd family, mfp subunit HXS64_RS17905 ENOG4105BZS acriflavin resistance protein HXS64_RS17910 ENOG4108UKR Biofilm formation regulator YbaJ HXS64_RS17915 ENOG4105KF5 hemolysin expression-modulating protein HXS64_RS17920 ENOG4108UW5 maltose o-acetyltransferase HXS64_RS17925 ENOG4105GSJ Inner membrane protein ylaC HXS64_RS17930 ENOG41066DG (EAL) domain protein HXS64_RS17935 ENOG4105KCV RNA signal recognition particle 4.5S RNA HXS64_RS17945 ENOG41080UX Methyltransferase HXS64_RS17950 ENOG4108MNP Glycoprotein polysaccharide metabolism HXS64_RS17955 ENOG4105C29 acyl-CoA thioesterase HXS64_RS17960 ENOG4105BZU Histidine kinase HXS64_RS17965 ENOG4108YZA Nitrogen regulatory protein pii HXS64_RS17970 ENOG4105BZ1 (ABC) transporter HXS64_RS17975 ENOG4105BZ1 (ABC) transporter HXS64_RS17980 ENOG4108XM1 transcriptional regulator AsnC family HXS64_RS17990 ENOG4108NFA extracellular solute-binding protein HXS64_RS18000 ENOG4108TGP Thioesterase superfamily protein HXS64_RS18005 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HXS64_RS18010 ENOG4105EIN peptidylprolyl cis-trans isomerase HXS64_RS18015 ENOG4105K70 DNA-binding protein HXS64_RS18020 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HXS64_RS18040 ENOG4105M85 Bola protein HXS64_RS18045 ENOG4105IEY (LipO)protein HXS64_RS18050 ENOG4105EYM Major Facilitator superfamily HXS64_RS18055 ENOG4105E2S oxidase) subunit II HXS64_RS18060 ENOG4105BZ9 Cytochrome C oxidase, subunit I HXS64_RS18065 ENOG4105CCU oxidase (Subunit III) HXS64_RS18070 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HXS64_RS18080 ENOG4107RDB Major Facilitator HXS64_RS18090 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HXS64_RS18095 ENOG4107S0N DJ-1 family HXS64_RS18100 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HXS64_RS18110 ENOG4105CTB Polyprenyl synthetase HXS64_RS18115 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HXS64_RS18120 ENOG4105CPC Aldo Keto reductase HXS64_RS18125 ENOG4108ZAI phosphatidylglycerophosphatase a HXS64_RS18130 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HXS64_RS18140 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HXS64_RS18145 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HXS64_RS18155 ENOG4108KIC (LipO)protein HXS64_RS18160 ENOG4105DRB nucleoside-specific channel-forming protein HXS64_RS18165 ENOG4105N1F Hnh endonuclease HXS64_RS18170 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HXS64_RS18175 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HXS64_RS18180 ENOG4105VIE preprotein translocase, subunit YajC HXS64_RS18195 ENOG4108ZYK Acyl carrier protein phosphodiesterase HXS64_RS18200 ENOG4107R28 alpha amylase, catalytic region HXS64_RS18205 ENOG4105C85 amino acid HXS64_RS18210 ENOG4105CWM branched-chain amino acid transport system II carrier protein HXS64_RS18215 ENOG4105BZU Histidine kinase HXS64_RS18220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HXS64_RS18225 ENOG4107RH8 nuclease SbcCD subunit D HXS64_RS18230 ENOG4105EYH Exonuclease HXS64_RS18235 ENOG4105F27 Major Facilitator HXS64_RS18240 ENOG4105DKQ ROK family HXS64_RS18265 ENOG4105HBA AroM protein HXS64_RS18270 ENOG4105SS3 HXS64_RS18280 ENOG4108UPT UPF0178 protein HXS64_RS18285 ENOG4105II7 pyrroline-5-carboxylate reductase HXS64_RS18290 ENOG4105BZU Histidine kinase HXS64_RS18295 ENOG4105VIF phosphate starvation-inducible protein HXS64_RS18300 ENOG4105G6Z alkaline phosphatase HXS64_RS18315 ENOG4105CPF Cell wall formation (By similarity) HXS64_RS18320 ENOG4105UNH Membrane HXS64_RS18325 ENOG4105FR5 inner membrane protein YaiY HXS64_RS18330 ENOG4107QS8 (LipO)protein HXS64_RS18335 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HXS64_RS18340 ENOG4107R6D beta-lactam binding protein AmpH HXS64_RS18365 ENOG4108NSE outer membrane autotransporter barrel HXS64_RS18370 ENOG4105D52 delta-aminolevulinic acid dehydratase HXS64_RS18375 ENOG4105E2B Taurine dioxygenase HXS64_RS18380 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HXS64_RS18385 ENOG4108ETV ABC transporter HXS64_RS18390 ENOG4106FTQ Taurine ABC transporter, periplasmic HXS64_RS18395 ENOG4107W19 lmbE family HXS64_RS18400 ENOG4108PBI Polysaccharide metabolism HXS64_RS18410 ENOG4105SRB Uncharacterized protein yaiO HXS64_RS18425 ENOG4105C4W S-formylglutathione hydrolase HXS64_RS18430 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HXS64_RS18435 ENOG4108SC4 )-transporter HXS64_RS18450 ENOG4105IKQ hydratase HXS64_RS18470 ENOG4108K2P TRANSCRIPTIONal HXS64_RS18475 ENOG4105ETE Transcriptional regulator (LacI family HXS64_RS18480 ENOG4105CNT hydrolase family 2 HXS64_RS18485 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HXS64_RS18490 ENOG4108UW5 maltose o-acetyltransferase HXS64_RS18500 ENOG4105DJ2 Major Facilitator Superfamily HXS64_RS18505 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HXS64_RS18510 ENOG4107B2H carbonic anhydrase HXS64_RS18520 ENOG4105DZC cytosine deaminase HXS64_RS18525 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HXS64_RS18530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HXS64_RS18535 ENOG4105DXD 2-methylcitrate dehydratase HXS64_RS18540 ENOG4105BZN citrate synthase HXS64_RS18545 ENOG4105CR4 methylisocitrate lyase HXS64_RS18550 ENOG4108JU7 Transcriptional regulator HXS64_RS18555 ENOG4105TDT uncharacterized protein yahO HXS64_RS18560 ENOG4105E82 cytochrome subunit of dehydrogenase HXS64_RS18575 ENOG4105DQ4 alcohol dehydrogenase HXS64_RS18580 ENOG4105DZC cytosine deaminase HXS64_RS18585 ENOG4105C5B carbamate kinase HXS64_RS18600 ENOG4107R1Q Membrane protein FdrA HXS64_RS18605 ENOG4105N16 Protein of unknown function (DUF2877) HXS64_RS18610 ENOG4107SNB ankyrin repeat protein YahD HXS64_RS18615 ENOG4105SZ2 membrAne HXS64_RS18620 ENOG4108NUU Transcriptional regulator HXS64_RS18640 ENOG4105C94 Transporter HXS64_RS18645 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HXS64_RS18650 ENOG4105C26 Dehydrogenase HXS64_RS18655 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HXS64_RS18675 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HXS64_RS18680 ENOG4107QR9 Iron-sulfur cluster binding protein HXS64_RS18685 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HXS64_RS18690 ENOG4108K01 transcriptional regulator HXS64_RS18695 ENOG4107QN2 dihydrolipoyl dehydrogenase HXS64_RS18700 ENOG41066GK UPF0379 protein ykgI HXS64_RS18705 ENOG4108KBJ Inner membrane protein YkgB HXS64_RS18745 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HXS64_RS18750 ENOG4108GWT fimbrillin MatB HXS64_RS18760 ENOG4108N3D putative enzyme HXS64_RS18765 ENOG4106PYX Receptor HXS64_RS18770 ENOG4108UD7 cell wall organization HXS64_RS18775 ENOG4105PI0 Ferredoxin HXS64_RS18790 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HXS64_RS18795 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HXS64_RS18800 ENOG4105C7W Xanthine dehydrogenase HXS64_RS18805 ENOG4107XAN XdhC and CoxI family HXS64_RS18935 ENOG4105DFP Integrase HXS64_RS18960 ENOG4107QUT magnesium and cobalt transport protein CorA HXS64_RS18965 ENOG4108T58 Mg2 transport protein CorA HXS64_RS19000 ENOG4105VDM plasmid maintenance system antidote protein, xre family HXS64_RS19025 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HXS64_RS19035 ENOG4105FCK Membrane HXS64_RS19045 ENOG4105V1F Fermentation respiration switch protein HXS64_RS19055 ENOG4105CIN aminoacyl-histidine dipeptidase HXS64_RS19070 ENOG4108HYG acetyltransferase HXS64_RS19075 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome HXS64_RS19080 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HXS64_RS19085 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HXS64_RS19100 ENOG4108UK5 Transposase HXS64_RS19105 ENOG4108YS0 lipoprotein YafL HXS64_RS19115 ENOG4105VXN addiction module toxin, RelE StbE family HXS64_RS19120 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HXS64_RS19125 ENOG4105E7A Glutamine amidotransferase HXS64_RS19135 ENOG4107QPN acyl-Coa dehydrogenase HXS64_RS19140 ENOG4108WN0 inhibitor of vertebrate lysozyme HXS64_RS19145 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HXS64_RS19165 ENOG4107RZZ dna polymerase iii epsilon subunit HXS64_RS19175 ENOG4105D1A Methyltransferase HXS64_RS19180 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HXS64_RS19185 ENOG4105E9H Lytic Murein transglycosylase HXS64_RS19200 ENOG4105HEI LysR family (Transcriptional regulator HXS64_RS19205 ENOG4105CV8 reductase HXS64_RS19240 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HXS64_RS19245 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HXS64_RS19250 ENOG4108UMI ABC transporter, permease HXS64_RS19255 ENOG4105D01 (LipO)protein HXS64_RS19260 ENOG4108R8X outer membrane lipoprotein HXS64_RS19265 ENOG4108R96 Methyltransferase, YaeB family HXS64_RS19280 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HXS64_RS19285 ENOG4108YZN class I peptide chain release factor HXS64_RS19290 ENOG4108VWS Yaeq family HXS64_RS19300 ENOG4105M1T rho-binding antiterminator HXS64_RS19305 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HXS64_RS19310 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HXS64_RS19315 ENOG4105CXN decarboxylase HXS64_RS19320 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HXS64_RS19325 ENOG4105C0B DNA polymerase III (alpha subunit) HXS64_RS19330 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HXS64_RS19335 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HXS64_RS19350 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HXS64_RS19355 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HXS64_RS19365 ENOG4105DZP Membrane-associated zinc metalloprotease HXS64_RS19370 ENOG4105KNE Phosphatidate cytidylyltransferase HXS64_RS19375 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HXS64_RS19380 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HXS64_RS19405 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HXS64_RS19410 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HXS64_RS19420 ENOG4105DIN metallophosphoesterase HXS64_RS19430 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HXS64_RS19435 ENOG4105C0H protease HXS64_RS19450 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HXS64_RS19455 ENOG4105EN6 Membrane HXS64_RS19480 ENOG4105S6R Iron-hydroxamate transporter permease subunit HXS64_RS19485 ENOG4105J76 Periplasmic binding protein HXS64_RS19490 ENOG4105E0A ABC, transporter HXS64_RS19495 ENOG4105E0K tonB-dependent siderophore receptor HXS64_RS19500 ENOG4105BZ4 penicillin-binding protein HXS64_RS19505 ENOG4105CQ7 ATP-dependent helicase HXS64_RS19510 ENOG4107XID 2'-5' rna ligase HXS64_RS19530 ENOG4105DJ0 Poly(A) Polymerase HXS64_RS19535 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HXS64_RS19545 ENOG4108VEV chaperone HXS64_RS19565 ENOG4108XEY fimbrial-like adhesin protein HXS64_RS19570 ENOG4105SYG Fimbrial protein HXS64_RS19585 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HXS64_RS19590 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HXS64_RS19595 ENOG4108A32 Transposase HXS64_RS19605 ENOG4107BJW polysaccharide deacetylase HXS64_RS19610 ENOG4108YTN IIa component HXS64_RS19615 ENOG4105E3A (ABC) transporter HXS64_RS19620 ENOG4105DA5 (ABC) transporter HXS64_RS19625 ENOG41077A9 carbonic anhydrase HXS64_RS19630 ENOG4108UGV hypoxanthine phosphoribosyltransferase HXS64_RS19635 ENOG4105DZG Dehydrogenase HXS64_RS19640 ENOG4105E3B Multicopper oxidase HXS64_RS19645 ENOG4108ZRK uncharacterized protein yacC HXS64_RS19665 ENOG4107QIJ Aconitate hydratase 2 HXS64_RS19670 ENOG4108NST exported protein HXS64_RS19675 ENOG4107QN2 dihydrolipoyl dehydrogenase HXS64_RS19680 ENOG4107QSN dihydrolipoamide acetyltransferase HXS64_RS19685 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HXS64_RS19690 ENOG41073TP transcriptional regulator HXS64_RS19695 ENOG4105C85 amino acid HXS64_RS19700 ENOG4106A72 regulatory protein AmpE HXS64_RS19705 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HXS64_RS19710 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HXS64_RS19715 ENOG4108ZUW Major pilin subunit HXS64_RS19720 ENOG4107QHF type ii secretion system protein e HXS64_RS19725 ENOG4105D7Q type ii secretion system HXS64_RS19740 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HXS64_RS19755 ENOG4105M6F mutator MutT protein HXS64_RS19765 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HXS64_RS19775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HXS64_RS19780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HXS64_RS19785 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HXS64_RS19790 ENOG4105CPF Cell wall formation (By similarity) HXS64_RS19795 ENOG4105DFU Cell wall formation (By similarity) HXS64_RS19800 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HXS64_RS19805 ENOG4105CNI cell division protein FtsW HXS64_RS19810 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HXS64_RS19820 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HXS64_RS19825 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HXS64_RS19830 ENOG4105CJN penicillin-binding protein HXS64_RS19835 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HXS64_RS19845 ENOG4108V6E Cell division protein mraZ HXS64_RS19850 ENOG4107B7Y DNA-binding transcriptional regulator FruR HXS64_RS19860 ENOG4108ZP8 Acetolactate synthase small subunit HXS64_RS19865 ENOG4105C7K acetolactate synthase HXS64_RS19875 ENOG41064T2 transcriptional regulator, lysR family HXS64_RS19890 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HXS64_RS19905 ENOG4105S8Q sugar efflux transporter HXS64_RS19920 ENOG4105DP9 ABC transporter HXS64_RS19925 ENOG4106SMU thiamine transporter membrane protein HXS64_RS19935 ENOG4108KF1 Membrane HXS64_RS19940 ENOG41063TF transcriptional regulator (AraC HXS64_RS19955 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HXS64_RS19960 ENOG4105CQ2 DNA polymerase HXS64_RS19965 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HXS64_RS19970 ENOG4105D3G Pseudouridine synthase HXS64_RS19975 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HXS64_RS19980 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HXS64_RS19985 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HXS64_RS20005 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HXS64_RS20010 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HXS64_RS20020 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HXS64_RS20025 ENOG4105C54 Major Facilitator superfamily HXS64_RS20030 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HXS64_RS20035 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HXS64_RS20060 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HXS64_RS20065 ENOG4105CEY Amp-dependent synthetase and ligase HXS64_RS20070 ENOG4106YT9 Enoyl-CoA hydratase HXS64_RS20075 ENOG4108Z0R Transferase HXS64_RS20080 ENOG4108XNW Transcriptional activatory protein CaiF HXS64_RS20085 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HXS64_RS20090 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HXS64_RS20095 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HXS64_RS20100 ENOG4105DU0 nucleoside hydrolase HXS64_RS20110 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HXS64_RS20115 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HXS64_RS20120 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HXS64_RS20125 ENOG4105DTN riboflavin biosynthesis protein ribF HXS64_RS20130 ENOG410647N response to DNA damage stimulus HXS64_RS20155 ENOG41063Z6 transcriptional regulator, lysR family HXS64_RS20195 ENOG4108QUJ UPF0174 protein YaaW HXS64_RS20200 ENOG4106HK8 GPR1 FUN34 yaaH family protein HXS64_RS20205 ENOG4108RIR Molybdenum cofactor biosynthesis protein HXS64_RS20210 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HXS64_RS20215 ENOG4105BZG amino acid carrier protein HXS64_RS20225 ENOG41062C6 Protein of unknown function (DUF2502) HXS64_RS20230 ENOG4105D98 threonine synthase HXS64_RS20240 ENOG4105CFH Aspartokinase HXS64_RS20250 ENOG4106FVC RNA methyltransferase HXS64_RS20255 ENOG410759A HXS64_RS20260 ENOG41065U4 response regulator HXS64_RS20265 ENOG4105CT7 inner membrane cred family protein HXS64_RS20270 ENOG4105EB3 Histidine kinase HXS64_RS20275 ENOG4105E3W Two component transcriptional regulator (Winged helix family HXS64_RS20280 ENOG4108RH0 Crea protein HXS64_RS20285 ENOG4105UEI Transcriptional Regulator AraC Family HXS64_RS20305 ENOG4107SC1 transglycosylase HXS64_RS20310 ENOG4105C5H ABC transporter HXS64_RS20320 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HXS64_RS20325 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HXS64_RS20330 ENOG4105EAC phosphoserine phosphatase HXS64_RS20335 ENOG41062Z9 Membrane HXS64_RS20370 ENOG4105G0K glycine radical enzyme YjjI family HXS64_RS20375 ENOG41076CZ activating enzyme HXS64_RS20380 ENOG4105EYA deoxyribonuclease HXS64_RS20385 ENOG4108NRW Phospholipase, patatin family HXS64_RS20395 ENOG4105K3G Periplasmic Protein HXS64_RS20405 ENOG4105PAD Hydrolase HXS64_RS20410 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HXS64_RS20415 ENOG4108WPU DNA polymerase III subunit psi HXS64_RS20420 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HXS64_RS20440 ENOG4105YBH Protein of unknown function (DUF1435) HXS64_RS20445 ENOG4108819 ferric iron reductase HXS64_RS20455 ENOG4108N8T regulatoR HXS64_RS20460 ENOG4105DWK Membrane HXS64_RS20475 ENOG4106CVF DNA replication protein HXS64_RS20480 ENOG4105RI1 glycoprotein receptor HXS64_RS20490 ENOG4105CPQ Dehydrogenase HXS64_RS20495 ENOG410617M Transcriptional regulator HXS64_RS20500 ENOG4108I5G Major Facilitator superfamily HXS64_RS20505 ENOG4105C8Q Methyl-accepting chemotaxis HXS64_RS20510 ENOG4105D22 carbon starvation protein HXS64_RS20515 ENOG4105VCD cytoplasmic protein HXS64_RS20520 ENOG4105CKI cobalamin synthesis protein HXS64_RS20540 ENOG41083G8 Multidrug resistance protein MdtM HXS64_RS20545 ENOG4106BRA Membrane HXS64_RS20550 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HXS64_RS20555 ENOG4105CIZ coA-substrate-specific enzyme activase HXS64_RS20570 ENOG4105CBP Major Facilitator HXS64_RS20580 ENOG41074DU domain protein HXS64_RS20585 ENOG4108P2H Inner membrane protein YjiG HXS64_RS20590 ENOG4105DYB Isoaspartyl dipeptidase HXS64_RS20595 ENOG4107YNJ LysR family Transcriptional regulator HXS64_RS20615 ENOG4105C6F GntR Family Transcriptional Regulator HXS64_RS20620 ENOG4105DEI Mannitol dehydrogenase HXS64_RS20630 ENOG4107EFN gluconate transport system permease 3 HXS64_RS20635 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HXS64_RS20640 ENOG4108T65 Fimbrial HXS64_RS20645 ENOG4108SQA Fimbrial HXS64_RS20665 ENOG4108NAE Fimbrial chaperone protein HXS64_RS20670 ENOG4108S54 Fimbrial protein HXS64_RS20680 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HXS64_RS20685 ENOG4108W9T type 1 fimbriae regulatory protein HXS64_RS20695 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HXS64_RS20700 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HXS64_RS20725 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HXS64_RS20745 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HXS64_RS20770 ENOG4105C94 Transporter HXS64_RS20785 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HXS64_RS20795 ENOG4107FB0 transcriptional regulator DeoR family HXS64_RS20805 ENOG4105EDR glucose galactose transporter HXS64_RS20820 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HXS64_RS20830 ENOG4106ETB IIa component HXS64_RS20865 ENOG4108YXQ IS66 Orf2 family protein HXS64_RS20895 ENOG4105DQ4 alcohol dehydrogenase HXS64_RS20900 ENOG4105D7A ATP-binding protein HXS64_RS20905 ENOG4108K5H permease YjgP YjgQ family protein HXS64_RS20910 ENOG4108M8S permease YjgP YjgQ family protein HXS64_RS20920 ENOG4105MYG DNA polymerase iii, chi subunit HXS64_RS20925 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HXS64_RS20930 ENOG4108M3P Membrane HXS64_RS20935 ENOG4108MJ3 acetyltransferase HXS64_RS20940 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HXS64_RS20955 ENOG4105XEP YhcH YjgK YiaL family protein HXS64_RS20960 ENOG4108XFH Transcriptional regulator HXS64_RS20965 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HXS64_RS20970 ENOG4108UQ8 endoribonuclease L-psp HXS64_RS20975 ENOG4107C93 pyrBI operon leader peptide HXS64_RS20990 ENOG4105KME endoribonuclease L-psp HXS64_RS20995 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HXS64_RS21005 ENOG4105D4X repressor HXS64_RS21010 ENOG4105C5Y PTS System HXS64_RS21015 ENOG4105CG3 alpha amylase, catalytic region HXS64_RS21020 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HXS64_RS21025 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HXS64_RS21030 ENOG4108XVM Cytochrome b(562) HXS64_RS21035 ENOG4105CMS peptidase U62, modulator of DNA gyrase HXS64_RS21045 ENOG4105DFU Cell wall formation (By similarity) HXS64_RS21055 ENOG41062B0 ABC transporter, permease HXS64_RS21060 ENOG4107R9N ABC transporter HXS64_RS21065 ENOG4105C2J ABC transporter HXS64_RS21070 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HXS64_RS21075 ENOG4105F0N pyrophosphate phospho-hydrolase HXS64_RS21080 ENOG4105MZG transcriptional modulator of maze toxin, mazf HXS64_RS21085 ENOG41087RY SpoVT_AbrB HXS64_RS21090 ENOG4108ZHD aig2 family HXS64_RS21095 ENOG4105MA0 exported protein HXS64_RS21100 ENOG4105CFU surface antigen HXS64_RS21110 ENOG4105C37 (CBS) domain HXS64_RS21115 ENOG41061GZ Protein of unknown function (DUF1107) HXS64_RS21120 ENOG4108UUE Transcriptional regulator HXS64_RS21125 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HXS64_RS21135 ENOG4105KVH Transcriptional regulator HXS64_RS21140 ENOG4105ECR NmrA family HXS64_RS21145 ENOG4105DXC membrane HXS64_RS21155 ENOG4105C85 amino acid HXS64_RS21160 ENOG4108V1T peptidylprolyl cis-trans isomerase HXS64_RS21165 ENOG4105FHY Opacity-associated protein A HXS64_RS21175 ENOG4105CHR reductase HXS64_RS21185 ENOG4105E39 Enoyl-CoA hydratase HXS64_RS21190 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HXS64_RS21195 ENOG4107S3R L-aspartate oxidase HXS64_RS21200 ENOG41069H7 transport system small permease component HXS64_RS21205 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HXS64_RS21210 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HXS64_RS21220 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HXS64_RS21235 ENOG4105KIT UPF0379 protein yjfY HXS64_RS21240 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HXS64_RS21260 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HXS64_RS21265 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HXS64_RS21280 ENOG4108MXZ Esterase HXS64_RS21285 ENOG4105WSB biofilm stress and motility protein A HXS64_RS21290 ENOG4105S17 UPF0379 protein yjfN HXS64_RS21295 ENOG4105CSU acyl-Coa dehydrogenase HXS64_RS21300 ENOG4106032 Glutathionylspermidine synthase HXS64_RS21305 ENOG4108KXT Conserved Protein HXS64_RS21310 ENOG4105Z6B inner membrane protein yjfl HXS64_RS21315 ENOG4107VNS Protein of unknown function (DUF2491) HXS64_RS21320 ENOG4108P9J Phage shock protein A HXS64_RS21325 ENOG4105FUX Conserved Protein HXS64_RS21330 ENOG4105C2N RNA methyltransferase TrmH family group 3 HXS64_RS21335 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HXS64_RS21355 ENOG4105EPW hflc protein HXS64_RS21360 ENOG4107QJR hflk protein HXS64_RS21365 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HXS64_RS21380 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HXS64_RS21385 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HXS64_RS21390 ENOG4105K8N protein family UPF0079, ATPase HXS64_RS21395 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HXS64_RS21400 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HXS64_RS21430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HXS64_RS21440 ENOG4105EGS Mechanosensitive ion channel HXS64_RS21445 ENOG4106CG8 Inner membrane protein YjeO HXS64_RS21450 ENOG4106V5W HXS64_RS21455 ENOG4107SC7 Inner membrane transporter yjeM HXS64_RS21460 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HXS64_RS21465 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HXS64_RS21470 ENOG4105E33 succinate dehydrogenase HXS64_RS21485 ENOG41066YJ Beta-lactamase HXS64_RS21490 ENOG4105QNF Outer membrane lipoprotein HXS64_RS21495 ENOG4105KPY Small multidrug resistance protein HXS64_RS21500 ENOG4106BSU Entericidin B HXS64_RS21505 ENOG4107PEH Entericidin EcnA/B family HXS64_RS21515 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HXS64_RS21525 ENOG4105MTB Uncharacterized protein YjeJ HXS64_RS21530 ENOG4108ZVF (LipO)protein HXS64_RS21545 ENOG4105DVH amino acid HXS64_RS21550 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HXS64_RS21555 ENOG4108IJ0 Aspartate ammonia-lyase HXS64_RS21560 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HXS64_RS21570 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HXS64_RS21575 ENOG4108SIC Transcriptional regulator HXS64_RS21590 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HXS64_RS21595 ENOG4108MRH transcriptional regulatory protein HXS64_RS21600 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HXS64_RS21605 ENOG4107GFK fumarate HXS64_RS21610 ENOG4108R5S membrane HXS64_RS21615 ENOG4105CT4 transporter HXS64_RS21620 ENOG4105F8D glycoside hydrolase family 4 HXS64_RS21625 ENOG4108K2B transcriptional regulator HXS64_RS21630 ENOG4105CXN decarboxylase HXS64_RS21635 ENOG4106ZGR Transcriptional regulator HXS64_RS21640 ENOG4105D5Q Arginine ornithine antiporter HXS64_RS21645 ENOG4105DIJ Phosphoethanolamine transferase HXS64_RS21650 ENOG4105XJC Two component transcriptional regulator (Winged helix family HXS64_RS21655 ENOG4105ECM Sensor protein basS pmrB HXS64_RS21665 ENOG4105CSH Transporter HXS64_RS21670 ENOG4108YIV HXS64_RS21675 ENOG4108F5E vimentin HXS64_RS21680 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HXS64_RS21685 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HXS64_RS21690 ENOG4105D5T phosphonate abc transporter HXS64_RS21695 ENOG4105EHI Phosphonate ABC transporter, periplasmic HXS64_RS21705 ENOG4107RJJ Transcriptional regulator HXS64_RS21710 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HXS64_RS21715 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HXS64_RS21720 ENOG4105EKV Phosphonate metabolism protein HXS64_RS21725 ENOG4105FT8 Phosphonate metabolism HXS64_RS21730 ENOG4105ENV phosphonate C-P lyase system protein PhnK HXS64_RS21735 ENOG4105HRV phosphonate c-p lyase system protein phnl HXS64_RS21740 ENOG4105FD8 phosphonate metabolism protein PhnM HXS64_RS21745 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HXS64_RS21750 ENOG410849A acetyltransferase, (GNAT) family HXS64_RS21755 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HXS64_RS21765 ENOG4108YZG isomerase HXS64_RS21770 ENOG4105NYY transcriptional regulator, RpiR HXS64_RS21785 ENOG4105EUZ Beta-lactamase domain protein HXS64_RS21790 ENOG4106833 HXS64_RS21795 ENOG4105J12 Multidrug resistance protein mdtN HXS64_RS21800 ENOG4108MI0 Resistance protein HXS64_RS21805 ENOG4105ETP RND efflux system, outer membrane lipoprotein HXS64_RS21815 ENOG41082ND Uncharacterized protein yjcO HXS64_RS21820 ENOG4105CK2 sodium dicarboxylate symporter HXS64_RS21825 ENOG4108W0S formate-dependent nitrite reductase complex HXS64_RS21835 ENOG4108QKW cytochrome c-type biogenesis protein HXS64_RS21840 ENOG4105DVI reductase, NrfD HXS64_RS21845 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HXS64_RS21850 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HXS64_RS21860 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HXS64_RS21865 ENOG41062QD Membrane HXS64_RS21880 ENOG4105EEQ Na H antiporter HXS64_RS21885 ENOG4105C7N Xanthine uracil vitamin C permease HXS64_RS21890 ENOG4108Z4X TRANSCRIPTIONal HXS64_RS21895 ENOG4108W3Q Transcriptional regulator HXS64_RS21905 ENOG4105PMV Membrane HXS64_RS21910 ENOG4108UUM single-stranded DNA-binding protein HXS64_RS21915 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HXS64_RS21920 ENOG4105MSB protein, conserved in bacteria HXS64_RS21925 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HXS64_RS21930 ENOG4105F0S class B acid phosphatase HXS64_RS21940 ENOG4105CGF Aromatic amino acid aminotransferase HXS64_RS21945 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HXS64_RS21950 ENOG4105CDU Replicative dna helicase HXS64_RS21955 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HXS64_RS21960 ENOG4105P4Z Phage shock protein G HXS64_RS21965 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HXS64_RS21975 ENOG4105MYN Zinc uptake regulation protein HXS64_RS21980 ENOG4105VDW Csbd family HXS64_RS21985 ENOG4107R73 Mate efflux family protein HXS64_RS21995 ENOG41080IJ Diacylglycerol kinase HXS64_RS22010 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HXS64_RS22020 ENOG4107W52 maltose operon periplasmic protein HXS64_RS22030 ENOG4108IJ9 (ABC) transporter HXS64_RS22035 ENOG4107FKK extracellular solute-binding protein family 1 HXS64_RS22040 ENOG4105D56 permease protein HXS64_RS22045 ENOG4105EG2 ABC transporter, permease HXS64_RS22050 ENOG4107QNK )-transporter HXS64_RS22065 ENOG4105E3R (LipO)protein HXS64_RS22070 ENOG4108Q9C Periplasmic Protein HXS64_RS22075 ENOG4108MDC (LipO)protein HXS64_RS22085 ENOG4107QP8 phosphohexose isomerase HXS64_RS22090 ENOG4105CFH Aspartokinase HXS64_RS22095 ENOG4108ZR5 Conserved Protein HXS64_RS22100 ENOG4105FE9 pseudouridine synthase HXS64_RS22110 ENOG4105EAM Na Pi-cotransporter HXS64_RS22115 ENOG4105C3R Methionine synthase HXS64_RS22120 ENOG41069M3 Transcriptional regulator HXS64_RS22130 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HXS64_RS22135 ENOG4108I9X Isocitrate lyase HXS64_RS22140 ENOG4107QP3 malate synthase g HXS64_RS22145 ENOG4105CVG Homoserine O-transsuccinylase HXS64_RS22150 ENOG4105K5X acetyltransferase HXS64_RS22155 ENOG41062WK cellular response to acidity HXS64_RS22180 ENOG4105DC1 bifunctional purine biosynthesis protein purh HXS64_RS22185 ENOG4105C12 Phosphoribosylglycinamide synthetase HXS64_RS22190 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HXS64_RS22195 ENOG4105BZU Histidine kinase HXS64_RS22200 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HXS64_RS22205 ENOG4108T8B Protein of unknown function (DUF1481) HXS64_RS22215 ENOG4105R2J Conserved Protein HXS64_RS22250 ENOG4105D06 uba thif-type nad fad binding protein HXS64_RS22255 ENOG4105WHD thiamine biosynthesis protein ThiS HXS64_RS22265 ENOG4105D41 biosynthesis protein thiH HXS64_RS22270 ENOG410645W Thiamin biosynthesis protein ThiH HXS64_RS22305 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HXS64_RS22310 ENOG4105PM1 preprotein translocase subunit SecE HXS64_RS22345 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HXS64_RS22350 ENOG4105D4A Cell wall formation (By similarity) HXS64_RS22355 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HXS64_RS22365 ENOG4106CQM replication HXS64_RS22395 ENOG4108BUD transposase HXS64_RS22430 ENOG4108BUD transposase HXS64_RS22450 ENOG4108BUD transposase HXS64_RS22485 ENOG4108BUD transposase HXS64_RS22505 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HXS64_RS22510 ENOG4105EPC oxidoreductase HXS64_RS22550 ENOG4108BUD transposase HXS64_RS22575 ENOG4105ESI atpase involved in dna repair HXS64_RS22615 ENOG41073YN Protein of unknown function (DUF1380) HXS64_RS22620 ENOG4106JQ7 HXS64_RS22640 ENOG4105EKQ RNA-directed DNA polymerase HXS64_RS22695 ENOG41074AV Hok/gef family HXS64_RS22905 ENOG4107U2T alpha beta HXS64_RS22910 ENOG4107CBI conjugal transfer fertility inhibition protein