locus-tag	class	description
HW43_RS00040	COG0814	amino acid
HW43_RS00055	COG2091	lysine biosynthetic process via aminoadipic acid
HW43_RS00060	COG0431	NADPH-dependent FMN reductase
HW43_RS00065	COG2252	PERMEase
HW43_RS00070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW43_RS00080	COG3196	Protein conserved in bacteria
HW43_RS00085	COG0363	glucosamine-6-phosphate deaminase activity
HW43_RS00090	COG2382	esterase
HW43_RS00100	COG2723	6-phospho-beta-galactosidase activity
HW43_RS00105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS00105	COG1263	PTS System
HW43_RS00105	COG2190	(PTS) system
HW43_RS00110	COG3711	transcriptional antiterminator
HW43_RS00115	COG0704	Plays a role in the regulation of phosphate uptake
HW43_RS00120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HW43_RS00125	COG0581	inorganic phosphate transmembrane transporter activity
HW43_RS00130	COG0573	inorganic phosphate transmembrane transporter activity
HW43_RS00135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW43_RS00145	COG3188	usher protein
HW43_RS00160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW43_RS00210	COG3312	ion transport
HW43_RS00225	COG0716	FMN binding
HW43_RS00230	COG1522	sequence-specific DNA binding
HW43_RS00265	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW43_RS00270	COG1879	ABC-type sugar transport system periplasmic component
HW43_RS00275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW43_RS00280	COG1609	Transcriptional regulator
HW43_RS00285	COG0477	Major facilitator Superfamily
HW43_RS00290	COG2186	Transcriptional regulator
HW43_RS00330	COG3085	chromosome segregation
HW43_RS00335	COG0606	chelatase, subunit chli
HW43_RS00350	COG3978	acetolactate synthase activity
HW43_RS00355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW43_RS00365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW43_RS00370	COG0583	DNA-binding transcription factor activity
HW43_RS00380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW43_RS00385	COG3692	DNA binding
HW43_RS00390	COG0210	DNA helicase
HW43_RS00405	COG3118	belongs to the thioredoxin family
HW43_RS00415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HW43_RS00425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW43_RS00430	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HW43_RS00435	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HW43_RS00440	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HW43_RS00445	COG1088	dTDP-glucose 4,6-dehydratase activity
HW43_RS00450	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HW43_RS00455	COG0456	acetyltransferase
HW43_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW43_RS00465	COG2244	polysaccharide biosynthetic process
HW43_RS00485	COG1113	amino acid transport
HW43_RS00510	COG0641	radical SAM
HW43_RS00515	COG3119	arylsulfatase activity
HW43_RS00520	COG3071	HemY protein
HW43_RS00525	COG2959	enzyme of heme biosynthesis
HW43_RS00530	COG1587	Uroporphyrinogen-III synthase
HW43_RS00540	COG3072	Adenylate cyclase
HW43_RS00565	COG5567	small periplasmic lipoprotein
HW43_RS00575	COG3159	Protein conserved in bacteria
HW43_RS00585	COG1011	Hydrolase
HW43_RS00590	COG0210	DNA helicase
HW43_RS00595	COG3698	Phosphodiester glycosidase
HW43_RS00605	COG0598	Magnesium transport protein CorA
HW43_RS00630	COG2962	Rard protein
HW43_RS00635	COG2050	protein possibly involved in aromatic compounds catabolism
HW43_RS00640	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HW43_RS00645	COG0514	ATP-dependent DNA helicase (RecQ)
HW43_RS00650	COG1280	lysine exporter protein (LysE YggA)
HW43_RS00655	COG1280	lysine exporter protein (LysE YggA)
HW43_RS00660	COG2267	carboxylic ester hydrolase activity
HW43_RS00665	COG0561	phosphatase activity
HW43_RS00670	COG0697	spore germination
HW43_RS00675	COG0583	DNA-binding transcription factor activity
HW43_RS00685	COG0412	Dienelactone hydrolase
HW43_RS00690	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HW43_RS00695	COG1322	Protein conserved in bacteria
HW43_RS00705	COG3165	ubiquinone biosynthetic process from chorismate
HW43_RS00715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW43_RS00720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW43_RS00725	COG0805	protein transport
HW43_RS00735	COG0250	Participates in transcription elongation, termination and antitermination
HW43_RS00740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HW43_RS00745	COG0543	2 iron, 2 sulfur cluster binding
HW43_RS00765	COG1739	Uncharacterized protein family UPF0029
HW43_RS00770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW43_RS00775	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HW43_RS00805	COG1763	Mo-molybdopterin cofactor biosynthetic process
HW43_RS00810	COG0746	molybdenum cofactor guanylyltransferase activity
HW43_RS00815	COG3084	Protein conserved in bacteria
HW43_RS00820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW43_RS00825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW43_RS00830	COG5339	Protein conserved in bacteria
HW43_RS00835	COG0204	Acyl-transferase
HW43_RS00845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW43_RS00845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW43_RS00860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW43_RS00870	COG2204	response regulator
HW43_RS00875	COG3852	Histidine kinase
HW43_RS00880	COG0174	glutamine synthetase
HW43_RS00890	COG1217	gtp-binding protein TYPA
HW43_RS00895	COG2188	Transcriptional regulator
HW43_RS00900	COG1082	Xylose isomerase domain protein TIM barrel
HW43_RS00905	COG2271	Major facilitator Superfamily
HW43_RS00910	COG1349	DNA-binding transcription factor activity
HW43_RS00915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW43_RS00920	COG2084	Dehydrogenase
HW43_RS00925	COG3684	Belongs to the aldolase LacD family
HW43_RS00930	COG1063	alcohol dehydrogenase
HW43_RS00940	COG0477	Major facilitator Superfamily
HW43_RS00950	COG1011	Hydrolase
HW43_RS00965	COG0456	acetyltransferase
HW43_RS00975	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HW43_RS00985	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HW43_RS00990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HW43_RS01005	COG2864	formate dehydrogenase
HW43_RS01010	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS01015	COG3383	formate dehydrogenase (NAD+) activity
HW43_RS01015	COG0243	molybdopterin cofactor binding
HW43_RS01020	COG3383	formate dehydrogenase (NAD+) activity
HW43_RS01020	COG0243	molybdopterin cofactor binding
HW43_RS01035	COG3711	transcriptional antiterminator
HW43_RS01035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS01040	COG1363	Peptidase, m42
HW43_RS01045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS01045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS01050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS01095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HW43_RS01110	COG2258	MOSC domain
HW43_RS01115	COG2205	protein histidine kinase activity
HW43_RS01120	COG0745	RESPONSE REGULATOR receiver
HW43_RS01125	COG3678	ATP-independent chaperone mediated protein folding
HW43_RS01140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HW43_RS01160	COG3152	Membrane
HW43_RS01165	COG3691	Protein conserved in bacteria
HW43_RS01170	COG0589	response to stress
HW43_RS01180	COG1494	fructose-1,6-bisphosphatase
HW43_RS01190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW43_RS01205	COG1575	Belongs to the MenA family. Type 1 subfamily
HW43_RS01220	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW43_RS01225	COG1609	Transcriptional regulator
HW43_RS01230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW43_RS01240	COG3209	COG3209 Rhs family protein
HW43_RS01270	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HW43_RS01280	COG0626	cystathionine gamma-synthase activity
HW43_RS01285	COG0460	homoserine dehydrogenase
HW43_RS01285	COG0527	aspartate kinase activity
HW43_RS01295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW43_RS01305	COG0697	spore germination
HW43_RS01310	COG3738	Protein conserved in bacteria
HW43_RS01320	COG0371	Dehydrogenase
HW43_RS01325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW43_RS01330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW43_RS01330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS01330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS01335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS01340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS01345	COG1882	Formate acetyltransferase
HW43_RS01350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HW43_RS01355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS01360	COG2207	Transcriptional regulator
HW43_RS01365	COG2194	sulfuric ester hydrolase activity
HW43_RS01380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HW43_RS01395	COG4948	Mandelate Racemase Muconate Lactonizing
HW43_RS01400	COG2271	Major facilitator Superfamily
HW43_RS01405	COG0583	DNA-binding transcription factor activity
HW43_RS01465	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HW43_RS01465	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HW43_RS01505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW43_RS01510	COG0250	Participates in transcription elongation, termination and antitermination
HW43_RS01545	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HW43_RS01555	COG2104	thiamine diphosphate biosynthetic process
HW43_RS01560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW43_RS01595	COG3068	Protein conserved in bacteria
HW43_RS01610	COG3678	ATP-independent chaperone mediated protein folding
HW43_RS01615	COG4191	Histidine kinase
HW43_RS01620	COG2204	response regulator
HW43_RS01625	COG0151	Belongs to the GarS family
HW43_RS01665	COG0456	acetyltransferase
HW43_RS01675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HW43_RS01680	COG2224	Isocitrate lyase
HW43_RS01695	COG1414	Transcriptional regulator
HW43_RS01700	COG1410	methionine synthase
HW43_RS01700	COG0646	methionine synthase
HW43_RS01705	COG1283	sodium-dependent phosphate transmembrane transporter activity
HW43_RS01730	COG3541	Predicted nucleotidyltransferase
HW43_RS01735	COG0542	response to heat
HW43_RS01740	COG0527	aspartate kinase activity
HW43_RS01765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW43_RS01785	COG2814	Major facilitator Superfamily
HW43_RS01785	COG0477	Major facilitator Superfamily
HW43_RS01790	COG3833	ABC-type maltose transport systems, permease component
HW43_RS01795	COG1175	transmembrane transport
HW43_RS01800	COG2182	Extracellular solute-binding protein
HW43_RS01810	COG3842	ATPase activity
HW43_RS01830	COG1357	PFAM Pentapeptide repeats (8 copies)
HW43_RS01850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HW43_RS01860	COG0534	Mate efflux family protein
HW43_RS01865	COG3237	CsbD-like
HW43_RS01870	COG0735	belongs to the Fur family
HW43_RS01880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW43_RS01890	COG0604	alcohol dehydrogenase
HW43_RS01895	COG0305	Participates in initiation and elongation during chromosome replication
HW43_RS01905	COG1448	Aminotransferase
HW43_RS01915	COG3700	Belongs to the class B bacterial acid phosphatase family
HW43_RS01920	COG0432	Pfam Uncharacterised protein family UPF0047
HW43_RS01925	COG2315	Protein conserved in bacteria
HW43_RS01930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW43_RS01935	COG0629	single-stranded DNA binding
HW43_RS01945	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HW43_RS01950	COG2207	Transcriptional regulator
HW43_RS01955	COG0789	Transcriptional regulator
HW43_RS01960	COG2252	PERMEase
HW43_RS01965	COG0025	NhaP-type Na H and K H
HW43_RS01970	COG1357	PFAM Pentapeptide repeats (8 copies)
HW43_RS01980	COG3162	membrane
HW43_RS01985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW43_RS01995	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HW43_RS02000	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS02005	COG3301	Polysulphide reductase, NrfD
HW43_RS02010	COG1138	Cytochrome C-type biogenesis protein
HW43_RS02015	COG3088	subunit of a heme lyase
HW43_RS02020	COG4235	cytochrome complex assembly
HW43_RS02025	COG1301	dicarboxylic acid transport
HW43_RS02030	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HW43_RS02035	COG3383	formate dehydrogenase (NAD+) activity
HW43_RS02040	COG3383	formate dehydrogenase (NAD+) activity
HW43_RS02050	COG1289	transmembrane transporter activity
HW43_RS02055	COG1566	PFAM secretion protein HlyD family protein
HW43_RS02065	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HW43_RS02070	COG1940	carbohydrate kinase activity
HW43_RS02075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW43_RS02080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW43_RS02085	COG1129	ABC transporter
HW43_RS02090	COG1879	ABC-type sugar transport system periplasmic component
HW43_RS02095	COG1737	Transcriptional regulator
HW43_RS02100	COG0698	ribose 5-phosphate isomerase
HW43_RS02110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW43_RS02115	COG0456	acetyltransferase
HW43_RS02120	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HW43_RS02125	COG3454	Phosphonate metabolism
HW43_RS02130	COG4778	phosphonate C-P lyase system protein PhnL
HW43_RS02135	COG4107	phosphonate C-P lyase system protein PhnK
HW43_RS02140	COG3627	carbon phosphorus lyase activity
HW43_RS02145	COG3626	phosphonate metabolism
HW43_RS02150	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HW43_RS02155	COG3624	Phosphonate C-P lyase system protein PhnG
HW43_RS02160	COG2188	Transcriptional regulator
HW43_RS02165	COG3639	organic phosphonate transmembrane transporter activity
HW43_RS02170	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HW43_RS02180	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HW43_RS02185	COG2824	Alkylphosphonate utilization operon protein PhnA
HW43_RS02200	COG0477	Major facilitator Superfamily
HW43_RS02210	COG0642	Histidine kinase
HW43_RS02215	COG0745	RESPONSE REGULATOR receiver
HW43_RS02220	COG2194	sulfuric ester hydrolase activity
HW43_RS02225	COG0531	amino acid
HW43_RS02230	COG2207	Transcriptional regulator
HW43_RS02235	COG1982	Orn Lys Arg decarboxylase major
HW43_RS02240	COG2169	Transcriptional regulator
HW43_RS02250	COG1486	melibiose metabolic process
HW43_RS02255	COG2211	Major facilitator Superfamily
HW43_RS02260	COG3647	Membrane
HW43_RS02265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HW43_RS02265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HW43_RS02270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HW43_RS02280	COG4565	transcriptional regulatory protein
HW43_RS02285	COG3290	protein histidine kinase activity
HW43_RS02290	COG3592	Divergent 4Fe-4S mono-cluster
HW43_RS02295	COG2388	GCN5-related N-acetyl-transferase
HW43_RS02315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HW43_RS02320	COG3104	oligopeptide transport
HW43_RS02325	COG1982	Orn Lys Arg decarboxylase major
HW43_RS02330	COG0531	amino acid
HW43_RS02335	COG3710	Transcriptional regulator
HW43_RS02350	COG1309	transcriptional regulator
HW43_RS02365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HW43_RS02370	COG1027	Aspartate ammonia-lyase
HW43_RS02375	COG3030	protein affecting phage T7 exclusion by the F plasmid
HW43_RS02380	COG0531	amino acid
HW43_RS02400	COG3547	Transposase (IS116 IS110 IS902 family)
HW43_RS02410	COG1509	lysine 2,3-aminomutase activity
HW43_RS02420	COG5510	response to toxic substance
HW43_RS02425	COG5510	response to toxic substance
HW43_RS02430	COG2076	Multidrug Resistance protein
HW43_RS02435	COG3040	lipid binding
HW43_RS02440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW43_RS02455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW43_RS02460	COG1053	succinate dehydrogenase
HW43_RS02470	COG0531	amino acid
HW43_RS02475	COG1511	domain protein
HW43_RS02475	COG3264	Mechanosensitive ion channel
HW43_RS02510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HW43_RS02515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HW43_RS02515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HW43_RS02520	COG0802	atpase or kinase
HW43_RS02525	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW43_RS02545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW43_RS02550	COG0330	HflC and HflK could
HW43_RS02555	COG0330	HflC and HflK could
HW43_RS02560	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HW43_RS02575	COG0557	exoribonuclease II activity
HW43_RS02580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW43_RS02585	COG3789	protein conserved in bacteria
HW43_RS02590	COG1842	Phage shock protein A
HW43_RS02600	COG3766	membrane
HW43_RS02605	COG5463	Belongs to the UPF0441 family
HW43_RS02610	COG0754	glutathionylspermidine amidase activity
HW43_RS02615	COG1960	acyl-CoA dehydrogenase activity
HW43_RS02625	COG3650	response to hydrogen peroxide
HW43_RS02630	COG1073	alpha beta
HW43_RS02645	COG3037	sugar-specific permease SgaT UlaA
HW43_RS02695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW43_RS02710	COG2271	Major facilitator Superfamily
HW43_RS02715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HW43_RS02720	COG4670	ketone body catabolic process
HW43_RS02725	COG1024	Enoyl-CoA hydratase
HW43_RS02740	COG1309	transcriptional regulator
HW43_RS02745	COG3061	Opacity-associated protein A
HW43_RS02750	COG0545	Peptidyl-prolyl cis-trans isomerase
HW43_RS02755	COG1113	amino acid transport
HW43_RS02765	COG0697	spore germination
HW43_RS02770	COG0702	epimerase
HW43_RS02775	COG1733	regulation of RNA biosynthetic process
HW43_RS02780	COG0737	Belongs to the 5'-nucleotidase family
HW43_RS02785	COG1218	3'(2'),5'-bisphosphate nucleotidase
HW43_RS02790	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HW43_RS02800	COG1253	flavin adenine dinucleotide binding
HW43_RS02815	COG0729	surface antigen
HW43_RS02820	COG2911	Protein conserved in bacteria
HW43_RS02825	COG2105	PFAM AIG2 family protein
HW43_RS02830	COG2336	PFAM SpoVT AbrB
HW43_RS02835	COG2337	Toxic component of a toxin-antitoxin (TA) module
HW43_RS02840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HW43_RS02845	COG1879	ABC-type sugar transport system periplasmic component
HW43_RS02850	COG1129	ABC transporter
HW43_RS02855	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW43_RS02860	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW43_RS02870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW43_RS02880	COG0312	modulator of DNA gyrase
HW43_RS02885	COG3783	Cytochrome b(562)
HW43_RS02890	COG0602	queuosine metabolic process
HW43_RS02895	COG1328	CTP reductase activity
HW43_RS02900	COG0366	Alpha amylase catalytic
HW43_RS02905	COG1263	PTS System
HW43_RS02905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS02910	COG1609	Transcriptional regulator
HW43_RS02915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HW43_RS02920	COG0251	oxidation-reduction process
HW43_RS02945	COG0251	oxidation-reduction process
HW43_RS02950	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS02955	COG1309	transcriptional regulator
HW43_RS02960	COG2731	YhcH YjgK YiaL family protein
HW43_RS02975	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HW43_RS02980	COG0456	acetyltransferase
HW43_RS02985	COG4269	membrane
HW43_RS02995	COG2927	DNA polymerase III (CHI subunit)
HW43_RS03005	COG0795	lipopolysaccharide-transporting ATPase activity
HW43_RS03010	COG0795	lipopolysaccharide-transporting ATPase activity
HW43_RS03015	COG0433	COG0433 Predicted ATPase
HW43_RS03020	COG1064	alcohol dehydrogenase
HW43_RS03030	COG0582	viral genome integration into host DNA
HW43_RS03050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW43_RS03055	COG0514	ATP-dependent DNA helicase (RecQ)
HW43_RS03090	COG0720	synthase
HW43_RS03105	COG3344	reverse transcriptase
HW43_RS03120	COG2801	Transposase and inactivated derivatives
HW43_RS03125	COG2826	transposase and inactivated derivatives, IS30 family
HW43_RS03130	COG2963	transposase activity
HW43_RS03135	COG2085	NADP oxidoreductase coenzyme F420-dependent
HW43_RS03140	COG1120	ATPase activity
HW43_RS03145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW43_RS03150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW43_RS03155	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HW43_RS03160	COG4772	TonB-dependent receptor
HW43_RS03165	COG3712	iron ion homeostasis
HW43_RS03170	COG1595	DNA-templated transcription, initiation
HW43_RS03175	COG3677	Transposase
HW43_RS03200	COG4372	Transposase
HW43_RS03235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HW43_RS03250	COG0582	viral genome integration into host DNA
HW43_RS03255	COG4974	Belongs to the 'phage' integrase family
HW43_RS03270	COG3539	Fimbrial protein
HW43_RS03275	COG3121	Chaperone
HW43_RS03280	COG3188	usher protein
HW43_RS03285	COG3539	Fimbrial protein
HW43_RS03290	COG3539	Fimbrial protein
HW43_RS03295	COG3539	Fimbrial protein
HW43_RS03300	COG2610	gluconate transmembrane transporter activity
HW43_RS03315	COG0246	Mannitol dehydrogenase
HW43_RS03325	COG2186	Transcriptional regulator
HW43_RS03350	COG0583	DNA-binding transcription factor activity
HW43_RS03355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW43_RS03360	COG0700	Nucleoside recognition
HW43_RS03365	COG3366	ferrous iron transmembrane transporter activity
HW43_RS03375	COG0477	Major facilitator Superfamily
HW43_RS03390	COG1924	4 iron, 4 sulfur cluster binding
HW43_RS03395	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HW43_RS03400	COG2733	membrane
HW43_RS03405	COG2814	Major facilitator Superfamily
HW43_RS03435	COG0523	cobalamin synthesis protein
HW43_RS03440	COG2879	small protein
HW43_RS03445	COG1966	Carbon starvation protein
HW43_RS03455	COG0840	transmembrane signaling receptor activity
HW43_RS03460	COG2271	Major facilitator Superfamily
HW43_RS03465	COG1802	Transcriptional regulator
HW43_RS03470	COG1063	alcohol dehydrogenase
HW43_RS03485	COG1484	DNA-dependent DNA replication
HW43_RS03500	COG2966	Psort location CytoplasmicMembrane, score
HW43_RS03505	COG2197	response regulator
HW43_RS03510	COG2197	response regulator
HW43_RS03515	COG4114	ferric iron reductase
HW43_RS03550	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HW43_RS03555	COG0456	acetyltransferase
HW43_RS03560	COG1011	Hydrolase
HW43_RS03570	COG2823	Periplasmic or secreted lipoprotein
HW43_RS03580	COG4667	esterase of the alpha-beta hydrolase superfamily
HW43_RS03585	COG0084	hydrolase, TatD family'
HW43_RS03590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HW43_RS03595	COG1328	CTP reductase activity
HW43_RS03635	COG3726	membrane protein affecting hemolysin expression
HW43_RS03640	COG0560	Phosphoserine phosphatase
HW43_RS03645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HW43_RS03650	COG1056	cytidyltransferase-related domain
HW43_RS03650	COG3172	ATPase kinase involved in NAD metabolism
HW43_RS03660	COG0488	(ABC) transporter
HW43_RS03665	COG0741	lytic transglycosylase activity
HW43_RS03685	COG3708	Transcriptional regulator
HW43_RS03685	COG2207	Transcriptional regulator
HW43_RS03690	COG3045	CreA protein
HW43_RS03695	COG0745	RESPONSE REGULATOR receiver
HW43_RS03700	COG2205	protein histidine kinase activity
HW43_RS03705	COG4452	Inner membrane protein CreD
HW43_RS03710	COG0745	RESPONSE REGULATOR receiver
HW43_RS03720	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HW43_RS03730	COG0460	homoserine dehydrogenase
HW43_RS03730	COG0527	aspartate kinase activity
HW43_RS03740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HW43_RS03755	COG3547	Transposase (IS116 IS110 IS902 family)
HW43_RS03765	COG1115	amino acid carrier protein
HW43_RS03770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW43_RS03775	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW43_RS03780	COG1584	GPR1 FUN34 yaaH family protein
HW43_RS03785	COG4735	regulation of single-species biofilm formation
HW43_RS03815	COG0583	DNA-binding transcription factor activity
HW43_RS03830	COG3188	usher protein
HW43_RS03850	COG0196	riboflavin kinase activity
HW43_RS03865	COG1047	Peptidyl-prolyl cis-trans
HW43_RS03895	COG0505	Belongs to the CarA family
HW43_RS03900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HW43_RS03955	COG4220	transposase activity
HW43_RS04045	COG0644	oxidoreductase
HW43_RS04050	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HW43_RS04055	COG2271	Major facilitator Superfamily
HW43_RS04070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW43_RS04095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW43_RS04100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HW43_RS04105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HW43_RS04110	COG0564	pseudouridine synthase activity
HW43_RS04120	COG0417	DNA replication proofreading
HW43_RS04125	COG0235	Class ii aldolase
HW43_RS04140	COG4977	sequence-specific DNA binding
HW43_RS04145	COG0586	Pfam SNARE associated Golgi protein
HW43_RS04155	COG1178	ABC-type Fe3 transport system permease component
HW43_RS04160	COG4143	(ABC) transporter
HW43_RS04175	COG2814	Major facilitator Superfamily
HW43_RS04190	COG0473	3-isopropylmalate dehydrogenase activity
HW43_RS04205	COG0583	DNA-binding transcription factor activity
HW43_RS04210	COG0028	Belongs to the TPP enzyme family
HW43_RS04215	COG0440	acetolactate synthase activity
HW43_RS04225	COG1609	Transcriptional regulator
HW43_RS04240	COG3116	cell division
HW43_RS04245	COG0768	penicillin binding
HW43_RS04250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW43_RS04255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW43_RS04270	COG0772	Belongs to the SEDS family
HW43_RS04285	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW43_RS04290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HW43_RS04295	COG0849	cell division
HW43_RS04300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW43_RS04320	COG0494	nUDIX hydrolase
HW43_RS04340	COG0237	dephospho-CoA kinase activity
HW43_RS04350	COG1459	type II secretion system
HW43_RS04355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW43_RS04360	COG4969	Belongs to the N-Me-Phe pilin family
HW43_RS04405	COG0157	Belongs to the NadC ModD family
HW43_RS04410	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW43_RS04415	COG3725	Membrane protein required for beta-lactamase induction
HW43_RS04420	COG1113	amino acid transport
HW43_RS04425	COG2186	Transcriptional regulator
HW43_RS04430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HW43_RS04435	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW43_RS04440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW43_RS04445	COG3064	Membrane
HW43_RS04450	COG1049	propionate catabolic process, 2-methylcitrate cycle
HW43_RS04475	COG2132	Multicopper oxidase
HW43_RS04480	COG4993	Dehydrogenase
HW43_RS04485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HW43_RS04490	COG0288	reversible hydration of carbon dioxide
HW43_RS04495	COG1131	(ABC) transporter
HW43_RS04500	COG0842	Transport permease protein
HW43_RS04505	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS04510	COG0726	polysaccharide deacetylase
HW43_RS04520	COG5464	transposase or invertase
HW43_RS04535	COG3539	Fimbrial protein
HW43_RS04540	COG3539	Fimbrial protein
HW43_RS04545	COG3539	Fimbrial protein
HW43_RS04550	COG3539	Fimbrial protein
HW43_RS04555	COG3188	usher protein
HW43_RS04560	COG3121	Chaperone
HW43_RS04565	COG3539	Fimbrial protein
HW43_RS04570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HW43_RS04575	COG0617	tRNA 3'-terminal CCA addition
HW43_RS04585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW43_RS04595	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW43_RS04600	COG1643	Atp-dependent helicase
HW43_RS04610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW43_RS04615	COG4774	siderophore transport
HW43_RS04620	COG1120	ATPase activity
HW43_RS04625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW43_RS04630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW43_RS04650	COG2860	membrane
HW43_RS04655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW43_RS04670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW43_RS04675	COG3835	regulator
HW43_RS04695	COG0024	Methionine aminopeptidase
HW43_RS04720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HW43_RS04725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW43_RS04730	COG0575	Belongs to the CDS family
HW43_RS04735	COG0750	zinc metalloprotease
HW43_RS04745	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HW43_RS04750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HW43_RS04775	COG0587	DNA-directed DNA polymerase activity
HW43_RS04785	COG1982	Orn Lys Arg decarboxylase major
HW43_RS04790	COG0346	lactoylglutathione lyase activity
HW43_RS04800	COG4568	rho-dependent transcription termination
HW43_RS04810	COG4681	YaeQ
HW43_RS04815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW43_RS04820	COG3015	lipoprotein NlpE involved in copper resistance
HW43_RS04825	COG3547	Transposase (IS116 IS110 IS902 family)
HW43_RS04830	COG0791	NLP P60 protein
HW43_RS04840	COG1720	tRNA m6t6A37 methyltransferase activity
HW43_RS04850	COG1464	Belongs to the NlpA lipoprotein family
HW43_RS04855	COG2011	ABC-type metal ion transport system permease component
HW43_RS04860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW43_RS04865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HW43_RS04900	COG0656	L-ascorbic acid biosynthetic process
HW43_RS04905	COG0583	DNA-binding transcription factor activity
HW43_RS04915	COG2226	methyltransferase
HW43_RS04920	COG1388	LysM domain
HW43_RS04920	COG0741	lytic transglycosylase activity
HW43_RS04930	COG2226	methyltransferase
HW43_RS04940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW43_RS04960	COG4104	PAAR repeat-containing protein
HW43_RS04965	COG3157	Type VI secretion system effector, Hcp
HW43_RS04980	COG3209	COG3209 Rhs family protein
HW43_RS04985	COG3209	COG3209 Rhs family protein
HW43_RS05005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW43_RS05015	COG1960	acyl-CoA dehydrogenase activity
HW43_RS05025	COG0121	glutamine amidotransferase
HW43_RS05030	COG3034	peptidoglycan biosynthetic process
HW43_RS05035	COG3041	Addiction module toxin RelE StbE family
HW43_RS05040	COG3077	Addiction module antitoxin, RelB DinJ family
HW43_RS05045	COG0791	NLP P60 protein
HW43_RS05075	COG0454	-acetyltransferase
HW43_RS05080	COG1690	Belongs to the RtcB family
HW43_RS05085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW43_RS05090	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW43_RS05110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HW43_RS05130	COG0583	DNA-binding transcription factor activity
HW43_RS05135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HW43_RS05140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW43_RS05145	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HW43_RS05150	COG2080	2 iron, 2 sulfur cluster binding
HW43_RS05155	COG3477	response to acidic pH
HW43_RS05160	COG0727	PFAM Uncharacterised protein family (UPF0153)
HW43_RS05165	COG3121	Chaperone
HW43_RS05175	COG3188	usher protein
HW43_RS05215	COG1388	LysM domain
HW43_RS05220	COG3708	Transcriptional regulator
HW43_RS05220	COG2207	Transcriptional regulator
HW43_RS05225	COG0656	L-ascorbic acid biosynthetic process
HW43_RS05230	COG3059	membrane
HW43_RS05240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW43_RS05245	COG2207	Transcriptional regulator
HW43_RS05250	COG0247	lactate metabolic process
HW43_RS05255	COG1139	Iron-sulfur cluster binding protein
HW43_RS05260	COG1556	Lactate utilization protein
HW43_RS05275	COG3468	outer membrane autotransporter barrel domain protein
HW43_RS05285	COG2200	EAL domain
HW43_RS05285	COG2771	luxR family
HW43_RS05315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW43_RS05325	COG2200	EAL domain
HW43_RS05325	COG2771	luxR family
HW43_RS05330	COG0583	DNA-binding transcription factor activity
HW43_RS05340	COG0666	response to abiotic stimulus
HW43_RS05350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW43_RS05355	COG1304	FMN binding
HW43_RS05360	COG0549	Belongs to the carbamate kinase family
HW43_RS05365	COG0402	S-adenosylhomocysteine deaminase activity
HW43_RS05375	COG1879	ABC-type sugar transport system periplasmic component
HW43_RS05380	COG1129	ABC transporter
HW43_RS05385	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW43_RS05395	COG1064	alcohol dehydrogenase
HW43_RS05410	COG1280	lysine exporter protein (LysE YggA)
HW43_RS05420	COG3829	transcription factor binding
HW43_RS05425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HW43_RS05430	COG0372	Belongs to the citrate synthase family
HW43_RS05435	COG2079	MmgE PrpD family protein
HW43_RS05440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW43_RS05445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW43_RS05450	COG0402	S-adenosylhomocysteine deaminase activity
HW43_RS05455	COG0583	DNA-binding transcription factor activity
HW43_RS05460	COG0288	reversible hydration of carbon dioxide
HW43_RS05470	COG2807	transmembrane transport
HW43_RS05475	COG2223	nitrite transmembrane transporter activity
HW43_RS05485	COG1609	Transcriptional regulator
HW43_RS05490	COG1414	Transcriptional regulator
HW43_RS05525	COG2814	Major facilitator Superfamily
HW43_RS05530	COG3122	Protein conserved in bacteria
HW43_RS05560	COG1215	transferase activity, transferring glycosyl groups
HW43_RS05565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW43_RS05570	COG4521	taurine ABC transporter
HW43_RS05575	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HW43_RS05580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW43_RS05585	COG2175	clavaminate synthase activity
HW43_RS05590	COG0113	porphobilinogen synthase activity
HW43_RS05595	COG3468	outer membrane autotransporter barrel domain protein
HW43_RS05600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW43_RS05605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW43_RS05615	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HW43_RS05635	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW43_RS05650	COG1785	Belongs to the alkaline phosphatase family
HW43_RS05660	COG3706	GGDEF domain
HW43_RS05665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW43_RS05690	COG4126	flavin adenine dinucleotide binding
HW43_RS05710	COG1940	carbohydrate kinase activity
HW43_RS05715	COG2814	Major facilitator Superfamily
HW43_RS05720	COG0419	ATPase involved in DNA repair
HW43_RS05725	COG0420	3'-5' exonuclease activity
HW43_RS05730	COG0745	RESPONSE REGULATOR receiver
HW43_RS05735	COG5002	protein histidine kinase activity
HW43_RS05740	COG1114	Component of the transport system for branched-chain amino acids
HW43_RS05745	COG1113	amino acid transport
HW43_RS05750	COG0366	Alpha amylase catalytic
HW43_RS05770	COG1862	Preprotein translocase
HW43_RS05775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW43_RS05780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW43_RS05785	COG1403	HNH endonuclease
HW43_RS05795	COG3248	Nucleoside-binding outer membrane protein
HW43_RS05800	COG4238	major outer membrane lipoprotein
HW43_RS05810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW43_RS05810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW43_RS05825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HW43_RS05830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW43_RS05835	COG0667	Aldo Keto reductase
HW43_RS05845	COG0142	geranyltranstransferase activity
HW43_RS05860	COG0693	protein deglycase activity
HW43_RS05865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW43_RS05875	COG2814	Major facilitator Superfamily
HW43_RS05900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HW43_RS05905	COG1845	cytochrome c oxidase, subunit III
HW43_RS05910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW43_RS05915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW43_RS05920	COG2223	nitrite transmembrane transporter activity
HW43_RS05925	COG3056	Lipoprotein
HW43_RS05930	COG0271	Belongs to the BolA IbaG family
HW43_RS05955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW43_RS05960	COG0776	regulation of translation
HW43_RS05965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW43_RS05970	COG1555	photosystem II stabilization
HW43_RS05975	COG0824	Thioesterase
HW43_RS05985	COG4533	DNA binding
HW43_RS05995	COG1522	sequence-specific DNA binding
HW43_RS06000	COG1132	(ABC) transporter
HW43_RS06005	COG1132	(ABC) transporter
HW43_RS06010	COG0347	Belongs to the P(II) protein family
HW43_RS06015	COG0004	ammonium transporteR
HW43_RS06020	COG1946	Acyl-CoA thioesterase
HW43_RS06025	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HW43_RS06030	COG3695	enzyme binding
HW43_RS06035	COG5507	3-demethylubiquinone-9 3-methyltransferase
HW43_RS06040	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HW43_RS06050	COG0110	maltose O-acetyltransferase activity
HW43_RS06065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW43_RS06070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW43_RS06075	COG1309	transcriptional regulator
HW43_RS06080	COG3264	Mechanosensitive ion channel
HW43_RS06080	COG1196	nuclear chromosome segregation
HW43_RS06095	COG3923	Primosomal replication protein n
HW43_RS06100	COG2832	Protein of unknown function (DUF454)
HW43_RS06110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW43_RS06145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW43_RS06150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW43_RS06150	COG4651	solute:proton antiporter activity
HW43_RS06155	COG2223	nitrite transmembrane transporter activity
HW43_RS06160	COG0737	Belongs to the 5'-nucleotidase family
HW43_RS06165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW43_RS06170	COG3735	TraB family
HW43_RS06175	COG3093	addiction module antidote protein HigA
HW43_RS06180	COG2217	Heavy metal translocating P-type atpase
HW43_RS06185	COG2066	Belongs to the glutaminase family
HW43_RS06190	COG0531	amino acid
HW43_RS06195	COG0789	Transcriptional regulator
HW43_RS06200	COG1585	Membrane protein implicated in regulation of membrane protease activity
HW43_RS06205	COG0330	HflC and HflK could
HW43_RS06210	COG4619	ABC transporter
HW43_RS06215	COG0390	transport system, permease component
HW43_RS06220	COG3118	belongs to the thioredoxin family
HW43_RS06225	COG0300	oxidoreductase activity
HW43_RS06230	COG2755	lipolytic protein G-D-S-L family
HW43_RS06235	COG4181	ATPase activity
HW43_RS06240	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HW43_RS06245	COG3209	COG3209 Rhs family protein
HW43_RS06255	COG2801	Transposase and inactivated derivatives
HW43_RS06265	COG0583	DNA-binding transcription factor activity
HW43_RS06275	COG1414	Transcriptional regulator
HW43_RS06280	COG3960	tartronate-semialdehyde synthase activity
HW43_RS06285	COG3622	Belongs to the hyi family
HW43_RS06290	COG2084	Dehydrogenase
HW43_RS06295	COG1953	Uracil, thiamine, allantoin
HW43_RS06310	COG2233	PERMEase
HW43_RS06315	COG1929	Belongs to the glycerate kinase type-1 family
HW43_RS06320	COG3257	ureidoglycine aminohydrolase activity
HW43_RS06325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW43_RS06330	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HW43_RS06335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW43_RS06340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW43_RS06350	COG0549	Belongs to the carbamate kinase family
HW43_RS06355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HW43_RS06360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HW43_RS06370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW43_RS06380	COG1988	membrane-bound metal-dependent
HW43_RS06385	COG2501	S4 domain
HW43_RS06395	COG3539	Fimbrial protein
HW43_RS06400	COG3121	Chaperone
HW43_RS06405	COG3188	usher protein
HW43_RS06410	COG3539	Fimbrial protein
HW43_RS06415	COG3539	Fimbrial protein
HW43_RS06420	COG2197	response regulator
HW43_RS06430	COG0582	viral genome integration into host DNA
HW43_RS06445	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HW43_RS06450	COG5532	Uncharacterized conserved protein (DUF2303)
HW43_RS06470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW43_RS06475	COG4197	protein conserved in bacteria, prophage-related
HW43_RS06490	COG1846	Transcriptional regulator
HW43_RS06500	COG4725	Belongs to the MT-A70-like family
HW43_RS06520	COG3772	lysozyme
HW43_RS06535	COG5562	phage envelope protein
HW43_RS06560	COG4220	transposase activity
HW43_RS06605	COG5301	cellulose 1,4-beta-cellobiosidase activity
HW43_RS06610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HW43_RS06615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW43_RS06625	COG0500	methyltransferase
HW43_RS06640	COG4571	Outer membrane protease
HW43_RS06650	COG2207	Transcriptional regulator
HW43_RS06660	COG4783	chaperone-mediated protein folding
HW43_RS06665	COG1215	transferase activity, transferring glycosyl groups
HW43_RS06670	COG5433	transposase activity
HW43_RS06690	COG4104	PAAR repeat-containing protein
HW43_RS06690	COG3209	COG3209 Rhs family protein
HW43_RS06705	COG5002	protein histidine kinase activity
HW43_RS06710	COG0745	RESPONSE REGULATOR receiver
HW43_RS06715	COG1538	Outer membrane efflux protein
HW43_RS06720	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW43_RS06725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW43_RS06730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW43_RS06735	COG1113	amino acid transport
HW43_RS06740	COG0668	transmembrane transport
HW43_RS06745	COG0778	Nitroreductase
HW43_RS06750	COG2315	Protein conserved in bacteria
HW43_RS06785	COG2977	Belongs to the P-Pant transferase superfamily
HW43_RS06790	COG4771	TonB-dependent receptor
HW43_RS06795	COG2382	esterase
HW43_RS06800	COG3251	PFAM MbtH domain protein
HW43_RS06805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW43_RS06805	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HW43_RS06810	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HW43_RS06815	COG1120	ATPase activity
HW43_RS06820	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW43_RS06825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW43_RS06835	COG4592	Periplasmic binding protein
HW43_RS06840	COG1169	isochorismate synthase
HW43_RS06845	COG1021	2,3-dihydroxybenzoate-AMP ligase
HW43_RS06850	COG1535	isochorismatase
HW43_RS06850	COG3433	isochorismatase activity
HW43_RS06855	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS06860	COG2050	protein possibly involved in aromatic compounds catabolism
HW43_RS06865	COG1966	Carbon starvation protein
HW43_RS06870	COG2879	small protein
HW43_RS06875	COG0371	Dehydrogenase
HW43_RS06880	COG0436	Aminotransferase
HW43_RS06885	COG1475	DNA binding
HW43_RS06890	COG3969	phosphoadenosine phosphosulfate
HW43_RS06895	COG0583	DNA-binding transcription factor activity
HW43_RS06900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW43_RS06905	COG0450	alkyl hydroperoxide reductase
HW43_RS06910	COG3634	alkyl hydroperoxide reductase activity
HW43_RS06915	COG0589	response to stress
HW43_RS06920	COG1063	alcohol dehydrogenase
HW43_RS06930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW43_RS06935	COG3719	Belongs to the RNase T2 family
HW43_RS06940	COG0471	metal ion transport
HW43_RS06955	COG3051	citrate lyase alpha subunit
HW43_RS06960	COG2301	Belongs to the HpcH HpaI aldolase family
HW43_RS06970	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HW43_RS06975	COG3290	protein histidine kinase activity
HW43_RS06980	COG4565	transcriptional regulatory protein
HW43_RS06985	COG3069	C4-dicarboxylate transmembrane transporter activity
HW43_RS07005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW43_RS07010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW43_RS07020	COG0583	DNA-binding transcription factor activity
HW43_RS07040	COG1686	Belongs to the peptidase S11 family
HW43_RS07045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HW43_RS07050	COG0772	Belongs to the SEDS family
HW43_RS07055	COG0768	penicillin binding
HW43_RS07065	COG0799	negative regulation of ribosome biogenesis
HW43_RS07070	COG0406	alpha-ribazole phosphatase activity
HW43_RS07080	COG1466	dna polymerase III delta subunit
HW43_RS07095	COG2888	peptidyl-tyrosine sulfation
HW43_RS07100	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HW43_RS07110	COG2214	Heat shock protein DnaJ domain protein
HW43_RS07115	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HW43_RS07125	COG2214	Heat shock protein DnaJ domain protein
HW43_RS07130	COG0443	Heat shock 70 kDa protein
HW43_RS07140	COG1126	abc transporter atp-binding protein
HW43_RS07145	COG0765	amino acid transport
HW43_RS07150	COG0765	amino acid transport
HW43_RS07155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS07165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HW43_RS07170	COG4535	Mg2 and Co2 transporter CorC
HW43_RS07180	COG1702	phosphate starvation-inducible protein PhoH
HW43_RS07190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW43_RS07230	COG0367	asparagine synthase
HW43_RS07235	COG0647	UMP catabolic process
HW43_RS07240	COG1940	carbohydrate kinase activity
HW43_RS07240	COG1846	Transcriptional regulator
HW43_RS07245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW43_RS07255	COG2190	(PTS) system
HW43_RS07255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS07255	COG1263	PTS System
HW43_RS07275	COG0735	belongs to the Fur family
HW43_RS07290	COG0716	FMN binding
HW43_RS07300	COG0596	Alpha beta hydrolase
HW43_RS07305	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HW43_RS07310	COG0033	Phosphoglucomutase
HW43_RS07315	COG0531	amino acid
HW43_RS07320	COG1982	Orn Lys Arg decarboxylase major
HW43_RS07330	COG0745	RESPONSE REGULATOR receiver
HW43_RS07335	COG2205	protein histidine kinase activity
HW43_RS07365	COG3209	COG3209 Rhs family protein
HW43_RS07375	COG3209	COG3209 Rhs family protein
HW43_RS07385	COG5433	transposase activity
HW43_RS07395	COG3272	Protein of unknown function (DUF1722)
HW43_RS07400	COG0415	Belongs to the DNA photolyase family
HW43_RS07410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW43_RS07415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HW43_RS07420	COG1984	allophanate hydrolase subunit 2
HW43_RS07435	COG3180	Ammonia monooxygenase
HW43_RS07440	COG3539	Fimbrial protein
HW43_RS07445	COG3121	Chaperone
HW43_RS07450	COG3188	usher protein
HW43_RS07455	COG3539	Fimbrial protein
HW43_RS07460	COG0372	Belongs to the citrate synthase family
HW43_RS07470	COG2009	succinate dehydrogenase
HW43_RS07475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HW43_RS07480	COG1053	succinate dehydrogenase
HW43_RS07485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW43_RS07495	COG0567	Dehydrogenase, E1 component
HW43_RS07500	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW43_RS07510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW43_RS07515	COG2188	Transcriptional regulator
HW43_RS07520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS07520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS07520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS07525	COG0383	alpha-mannosidase activity
HW43_RS07535	COG1271	oxidase subunit
HW43_RS07540	COG1294	oxidase, subunit
HW43_RS07545	COG4890	Cyd operon protein YbgT
HW43_RS07550	COG3790	cyd operon protein YbgE
HW43_RS07555	COG0824	Thioesterase
HW43_RS07560	COG0811	peptide transport
HW43_RS07565	COG0848	biopolymer transport protein
HW43_RS07570	COG3064	Membrane
HW43_RS07580	COG2885	chlorophyll binding
HW43_RS07585	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HW43_RS07630	COG3201	nicotinamide mononucleotide transporter
HW43_RS07635	COG1230	cation diffusion facilitator family transporter
HW43_RS07650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HW43_RS07660	COG2017	converts alpha-aldose to the beta-anomer
HW43_RS07670	COG1085	galactose-1-phosphate uridylyltransferase
HW43_RS07675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW43_RS07680	COG1119	ATPase activity
HW43_RS07685	COG3585	molybdate ion transport
HW43_RS07685	COG2005	Transcriptional regulator
HW43_RS07695	COG0725	ABC transporter, periplasmic molybdate-binding protein
HW43_RS07700	COG4149	molybdate abc transporter
HW43_RS07710	COG0561	phosphatase activity
HW43_RS07720	COG0583	DNA-binding transcription factor activity
HW43_RS07725	COG2828	Protein conserved in bacteria
HW43_RS07730	COG0471	metal ion transport
HW43_RS07735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW43_RS07740	COG4677	pectinesterase activity
HW43_RS07745	COG1881	PFAM PEBP family protein
HW43_RS07750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW43_RS07765	COG2226	methyltransferase
HW43_RS07770	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HW43_RS07780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HW43_RS07795	COG0521	Mo-molybdopterin cofactor biosynthetic process
HW43_RS07805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HW43_RS07810	COG0314	molybdopterin synthase activity
HW43_RS07815	COG0670	Belongs to the BI1 family
HW43_RS07825	COG0670	Belongs to the BI1 family
HW43_RS07830	COG0392	lysyltransferase activity
HW43_RS07835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW43_RS07840	COG3568	Endonuclease Exonuclease Phosphatase
HW43_RS07850	COG0842	Transport permease protein
HW43_RS07855	COG0842	Transport permease protein
HW43_RS07860	COG1131	(ABC) transporter
HW43_RS07870	COG1309	transcriptional regulator
HW43_RS07875	COG0513	Belongs to the DEAD box helicase family
HW43_RS07880	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HW43_RS07885	COG1199	ATP-dependent helicase activity
HW43_RS07890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW43_RS07895	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HW43_RS07905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW43_RS07930	COG0668	transmembrane transport
HW43_RS07940	COG1126	abc transporter atp-binding protein
HW43_RS07945	COG0765	amino acid transport
HW43_RS07950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS07965	COG5006	permease, DMT superfamily
HW43_RS07970	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW43_RS07975	COG2194	sulfuric ester hydrolase activity
HW43_RS07985	COG1321	iron dependent repressor
HW43_RS07990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW43_RS07995	COG1376	ErfK ybiS ycfS ynhG family protein
HW43_RS08000	COG0488	(ABC) transporter
HW43_RS08005	COG3547	Transposase (IS116 IS110 IS902 family)
HW43_RS08015	COG0561	phosphatase activity
HW43_RS08020	COG1882	Formate acetyltransferase
HW43_RS08025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HW43_RS08030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW43_RS08035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW43_RS08040	COG0303	'Molybdopterin
HW43_RS08045	COG1446	asparaginase
HW43_RS08070	COG2200	EAL domain
HW43_RS08075	COG2199	diguanylate cyclase activity
HW43_RS08090	COG2133	pyrroloquinoline quinone binding
HW43_RS08095	COG0625	glutathione transferase activity
HW43_RS08100	COG1686	Belongs to the peptidase S11 family
HW43_RS08105	COG1349	DNA-binding transcription factor activity
HW43_RS08110	COG0671	phosphoesterase, PA-phosphatase related
HW43_RS08115	COG2814	Major facilitator Superfamily
HW43_RS08125	COG0561	phosphatase activity
HW43_RS08130	COG0738	Major facilitator superfamily
HW43_RS08135	COG3226	Transcriptional regulator
HW43_RS08150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HW43_RS08160	COG0778	Nitroreductase
HW43_RS08180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW43_RS08185	COG3842	ATPase activity
HW43_RS08190	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW43_RS08195	COG1177	transmembrane transport
HW43_RS08210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS08215	COG4160	amino acid transport
HW43_RS08220	COG4215	(ABC) transporter
HW43_RS08225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS08230	COG1126	abc transporter atp-binding protein
HW43_RS08245	COG3023	N-Acetylmuramoyl-L-alanine amidase
HW43_RS08250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW43_RS08255	COG0702	epimerase
HW43_RS08260	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HW43_RS08265	COG0028	Belongs to the TPP enzyme family
HW43_RS08270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW43_RS08280	COG2431	L-lysine efflux transmembrane transporter activity
HW43_RS08285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW43_RS08295	COG3593	DNA synthesis involved in DNA repair
HW43_RS08300	COG2990	Protein conserved in bacteria
HW43_RS08305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW43_RS08310	COG1136	(ABC) transporter
HW43_RS08310	COG0577	efflux transmembrane transporter activity
HW43_RS08315	COG1278	Cold shock
HW43_RS08325	COG0542	response to heat
HW43_RS08345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HW43_RS08350	COG4988	ABC transporter
HW43_RS08355	COG0492	ferredoxin-NADP+ reductase activity
HW43_RS08360	COG1522	sequence-specific DNA binding
HW43_RS08375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW43_RS08385	COG0243	molybdopterin cofactor binding
HW43_RS08390	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS08395	COG3302	dmso reductase anchor subunit
HW43_RS08400	COG1335	isochorismatase
HW43_RS08410	COG0531	amino acid
HW43_RS08415	COG0583	DNA-binding transcription factor activity
HW43_RS08420	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW43_RS08425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HW43_RS08430	COG1882	Formate acetyltransferase
HW43_RS08435	COG2116	formate transmembrane transporter activity
HW43_RS08440	COG1944	ATP diphosphatase activity
HW43_RS08445	COG2323	membrane
HW43_RS08460	COG0501	Belongs to the peptidase M48B family
HW43_RS08470	COG0539	negative regulation of cytoplasmic translation
HW43_RS08480	COG0658	competence protein
HW43_RS08480	COG2333	competence protein COMEC
HW43_RS08485	COG1132	(ABC) transporter
HW43_RS08495	COG3214	Protein conserved in bacteria
HW43_RS08510	COG3173	Aminoglycoside phosphotransferase
HW43_RS08515	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HW43_RS08520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW43_RS08530	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HW43_RS08540	COG2989	Protein conserved in bacteria
HW43_RS08545	COG3108	Peptidase M15
HW43_RS08550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW43_RS08555	COG1448	Aminotransferase
HW43_RS08580	COG0308	aminopeptidase N
HW43_RS08590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW43_RS08600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW43_RS08605	COG0431	NADPH-dependent FMN reductase
HW43_RS08610	COG3539	Fimbrial protein
HW43_RS08615	COG3121	Chaperone
HW43_RS08620	COG3188	usher protein
HW43_RS08625	COG3539	Fimbrial protein
HW43_RS08630	COG3539	Fimbrial protein
HW43_RS08635	COG3539	Fimbrial protein
HW43_RS08640	COG3121	Chaperone
HW43_RS08655	COG3217	Mosc domain protein beta barrel domain protein
HW43_RS08655	COG0633	Ferredoxin
HW43_RS08665	COG0488	(ABC) transporter
HW43_RS08670	COG2995	paraquat-inducible protein a
HW43_RS08675	COG3008	intermembrane lipid transfer
HW43_RS08675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HW43_RS08680	COG3009	Protein conserved in bacteria
HW43_RS08685	COG3130	regulation of translation
HW43_RS08695	COG1067	ATP-dependent peptidase activity
HW43_RS08705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HW43_RS08705	COG2885	chlorophyll binding
HW43_RS08720	COG3070	regulator of competence-specific genes
HW43_RS08725	COG1289	transmembrane transporter activity
HW43_RS08730	COG3304	Inner membrane component domain
HW43_RS08735	COG0210	DNA helicase
HW43_RS08755	COG1832	CoA-binding protein
HW43_RS08770	COG1254	Belongs to the acylphosphatase family
HW43_RS08775	COG2920	part of a sulfur-relay system
HW43_RS08780	COG0670	Belongs to the BI1 family
HW43_RS08790	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HW43_RS08795	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HW43_RS08800	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HW43_RS08805	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HW43_RS08810	COG1999	signal sequence binding
HW43_RS08815	COG1773	rubredoxin
HW43_RS08820	COG1271	oxidase subunit
HW43_RS08825	COG1294	oxidase, subunit
HW43_RS08840	COG0489	protein tyrosine kinase activity
HW43_RS08840	COG3206	protein involved in exopolysaccharide biosynthesis
HW43_RS08845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW43_RS08850	COG1596	polysaccharide export
HW43_RS08855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW43_RS08875	COG1278	Cold shock
HW43_RS08880	COG1278	Cold shock
HW43_RS08895	COG0348	domain, Protein
HW43_RS08900	COG2198	Histidine kinase
HW43_RS08900	COG2205	protein histidine kinase activity
HW43_RS08900	COG0784	Response regulator, receiver
HW43_RS08905	COG1879	ABC-type sugar transport system periplasmic component
HW43_RS08910	COG0745	RESPONSE REGULATOR receiver
HW43_RS08915	COG3005	denitrification pathway
HW43_RS08920	COG0243	molybdopterin cofactor binding
HW43_RS08965	COG3729	General stress protein
HW43_RS08970	COG2233	PERMEase
HW43_RS08995	COG1335	isochorismatase
HW43_RS09005	COG1309	transcriptional regulator
HW43_RS09010	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HW43_RS09010	COG0506	proline dehydrogenase activity
HW43_RS09010	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HW43_RS09020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW43_RS09035	COG2822	iron ion transport
HW43_RS09050	COG1702	phosphate starvation-inducible protein PhoH
HW43_RS09055	COG3658	cytochrome
HW43_RS09060	COG1215	transferase activity, transferring glycosyl groups
HW43_RS09065	COG1649	PFAM Uncharacterised BCR, COG1649
HW43_RS09065	COG0726	polysaccharide deacetylase
HW43_RS09070	COG0457	Tetratricopeptide repeat
HW43_RS09075	COG3706	GGDEF domain
HW43_RS09080	COG2801	Transposase and inactivated derivatives
HW43_RS09115	COG3381	protein complex oligomerization
HW43_RS09125	COG1462	curli production assembly transport component CsgG
HW43_RS09140	COG2197	response regulator
HW43_RS09170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HW43_RS09175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW43_RS09200	COG2943	transferase activity, transferring hexosyl groups
HW43_RS09205	COG5645	(Lipo)protein
HW43_RS09225	COG1560	Kdo2-lipid A biosynthetic process
HW43_RS09235	COG2353	YceI-like domain
HW43_RS09240	COG3038	cytochrome b561
HW43_RS09275	COG2999	glutathione oxidoreductase activity
HW43_RS09285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW43_RS09295	COG0673	inositol 2-dehydrogenase activity
HW43_RS09300	COG0728	peptidoglycan biosynthetic process
HW43_RS09305	COG3418	PFAM FlgN family protein
HW43_RS09310	COG2747	anti-sigma28 factor FlgM
HW43_RS09315	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HW43_RS09320	COG1815	bacterial-type flagellum-dependent cell motility
HW43_RS09325	COG1558	bacterial-type flagellum-dependent cell motility
HW43_RS09330	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW43_RS09335	COG1749	Flagellar hook protein flgE
HW43_RS09340	COG4787	bacterial-type flagellum-dependent cell motility
HW43_RS09345	COG4786	Flagellar basal body rod
HW43_RS09360	COG3951	Flagellar rod assembly protein muramidase FlgJ
HW43_RS09360	COG1705	Flagellar rod assembly protein muramidase FlgJ
HW43_RS09365	COG1256	bacterial-type flagellum assembly
HW43_RS09370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW43_RS09375	COG1530	ribonuclease E activity
HW43_RS09385	COG0564	pseudouridine synthase activity
HW43_RS09390	COG0424	maF-like protein
HW43_RS09395	COG1399	metal-binding, possibly nucleic acid-binding protein
HW43_RS09415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW43_RS09420	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS09430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW43_RS09435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW43_RS09440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW43_RS09450	COG0470	DNA polymerase III
HW43_RS09455	COG0084	hydrolase, TatD family'
HW43_RS09460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS09460	COG1263	PTS System
HW43_RS09465	COG4773	Receptor
HW43_RS09470	COG0537	adenosine 5'-monophosphoramidase activity
HW43_RS09475	COG5633	Lipoprotein
HW43_RS09480	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HW43_RS09500	COG1252	NADH dehydrogenase
HW43_RS09505	COG3134	Outer membrane lipoprotein
HW43_RS09510	COG1309	transcriptional regulator
HW43_RS09520	COG1376	ErfK ybiS ycfS ynhG family protein
HW43_RS09520	COG1388	LysM domain
HW43_RS09525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW43_RS09530	COG4763	Acyl-transferase
HW43_RS09535	COG4591	ABC-type transport system involved in lipoprotein release permease component
HW43_RS09540	COG1136	(ABC) transporter
HW43_RS09545	COG4591	ABC-type transport system involved in lipoprotein release permease component
HW43_RS09555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HW43_RS09560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW43_RS09570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW43_RS09575	COG1177	transmembrane transport
HW43_RS09600	COG2850	peptidyl-arginine hydroxylation
HW43_RS09710	COG4626	Terminase
HW43_RS09710	COG1802	Transcriptional regulator
HW43_RS09720	COG2205	protein histidine kinase activity
HW43_RS09730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW43_RS09750	COG1187	pseudouridine synthase activity
HW43_RS09755	COG0538	isocitrate dehydrogenase activity
HW43_RS09770	COG5562	phage envelope protein
HW43_RS09775	COG0789	Transcriptional regulator
HW43_RS09780	COG2200	EAL domain
HW43_RS09805	COG2200	EAL domain
HW43_RS09855	COG2894	cell division
HW43_RS09880	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW43_RS09900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW43_RS09905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW43_RS09910	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HW43_RS09925	COG2719	SpoVR family
HW43_RS09935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HW43_RS09945	COG1619	proteins homologs of microcin C7 resistance protein MccF
HW43_RS09955	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HW43_RS09975	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HW43_RS09975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS09975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW43_RS09980	COG1461	Dihydroxyacetone kinase
HW43_RS09985	COG2376	Dihydroxyacetone kinase
HW43_RS09990	COG3284	Transcriptional regulator
HW43_RS09995	COG3468	outer membrane autotransporter barrel domain protein
HW43_RS10005	COG0012	GTP binding
HW43_RS10020	COG0659	secondary active sulfate transmembrane transporter activity
HW43_RS10025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HW43_RS10050	COG2890	protein-(glutamine-N5) methyltransferase activity
HW43_RS10055	COG3094	Invasion gene expression up-regulator, SirB
HW43_RS10060	COG2912	Transglutaminase-like superfamily
HW43_RS10085	COG0387	Pfam Sodium calcium exchanger
HW43_RS10090	COG4572	Cation transport regulator
HW43_RS10095	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HW43_RS10100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HW43_RS10105	COG4932	domain protein
HW43_RS10110	COG2197	response regulator
HW43_RS10115	COG3850	Histidine kinase
HW43_RS10125	COG2223	nitrite transmembrane transporter activity
HW43_RS10130	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HW43_RS10135	COG1140	nitrate reductase beta subunit
HW43_RS10140	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HW43_RS10145	COG2181	nitrate reductase activity
HW43_RS10160	COG0788	formyltetrahydrofolate deformylase activity
HW43_RS10170	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW43_RS10175	COG0745	RESPONSE REGULATOR receiver
HW43_RS10180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW43_RS10190	COG1435	thymidine kinase activity
HW43_RS10195	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS10195	COG1454	alcohol dehydrogenase
HW43_RS10200	COG2095	MarC family integral membrane protein
HW43_RS10205	COG4166	transmembrane transport
HW43_RS10210	COG0601	transmembrane transport
HW43_RS10215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW43_RS10220	COG0444	Belongs to the ABC transporter superfamily
HW43_RS10225	COG4608	Belongs to the ABC transporter superfamily
HW43_RS10245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HW43_RS10250	COG2350	Protein conserved in bacteria
HW43_RS10255	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HW43_RS10260	COG1607	acyl-coa hydrolase
HW43_RS10275	COG3047	cAMP biosynthetic process
HW43_RS10280	COG0582	viral genome integration into host DNA
HW43_RS10290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW43_RS10325	COG1396	sequence-specific DNA binding
HW43_RS10340	COG1846	Transcriptional regulator
HW43_RS10345	COG1484	DNA-dependent DNA replication
HW43_RS10350	COG1846	Transcriptional regulator
HW43_RS10395	COG1403	HNH endonuclease
HW43_RS10400	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HW43_RS10435	COG3064	Membrane
HW43_RS10440	COG2207	Transcriptional regulator
HW43_RS10475	COG3772	lysozyme
HW43_RS10625	COG5301	cellulose 1,4-beta-cellobiosidase activity
HW43_RS10640	COG3685	Protein conserved in bacteria
HW43_RS10645	COG3685	Protein conserved in bacteria
HW43_RS10650	COG3729	General stress protein
HW43_RS10665	COG0135	phosphoribosylanthranilate isomerase activity
HW43_RS10665	COG0134	indole-3-glycerol-phosphate synthase activity
HW43_RS10670	COG0512	Glutamine amidotransferase of anthranilate synthase
HW43_RS10670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW43_RS10675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW43_RS10680	COG0613	PHP domain protein
HW43_RS10685	COG0009	L-threonylcarbamoyladenylate synthase
HW43_RS10690	COG1187	pseudouridine synthase activity
HW43_RS10695	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HW43_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS10710	COG0616	signal peptide processing
HW43_RS10725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW43_RS10730	COG0583	DNA-binding transcription factor activity
HW43_RS10750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW43_RS10760	COG0671	phosphoesterase, PA-phosphatase related
HW43_RS10765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HW43_RS10770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HW43_RS10780	COG0023	Translation Initiation Factor
HW43_RS10790	COG1349	DNA-binding transcription factor activity
HW43_RS10800	COG5001	Diguanylate cyclase
HW43_RS10815	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW43_RS10815	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW43_RS10820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HW43_RS10830	COG2852	Protein conserved in bacteria
HW43_RS10835	COG4172	Belongs to the ABC transporter superfamily
HW43_RS10840	COG4172	Belongs to the ABC transporter superfamily
HW43_RS10845	COG4171	peptide transport system, permease
HW43_RS10850	COG4168	peptide transport system, permease
HW43_RS10855	COG4166	transmembrane transport
HW43_RS10870	COG0531	amino acid
HW43_RS10875	COG0174	glutamine synthetase
HW43_RS10880	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HW43_RS10885	COG1917	Cupin 2, conserved barrel domain protein
HW43_RS10885	COG1396	sequence-specific DNA binding
HW43_RS10890	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS10895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW43_RS10900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW43_RS10905	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HW43_RS10910	COG1842	Phage shock protein A
HW43_RS10920	COG1983	PspC domain protein
HW43_RS10930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW43_RS10935	COG0366	Alpha amylase catalytic
HW43_RS10940	COG1653	transport
HW43_RS10945	COG1175	transmembrane transport
HW43_RS10950	COG0395	ABC-type sugar transport system, permease component
HW43_RS10960	COG1082	Xylose isomerase domain protein TIM barrel
HW43_RS10965	COG0673	inositol 2-dehydrogenase activity
HW43_RS10970	COG1554	hydrolase, family 65, central catalytic
HW43_RS10975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW43_RS10980	COG3842	ATPase activity
HW43_RS10990	COG1609	Transcriptional regulator
HW43_RS10995	COG3106	COG3106 Predicted ATPase
HW43_RS11005	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HW43_RS11010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HW43_RS11015	COG4948	Mandelate Racemase Muconate Lactonizing
HW43_RS11020	COG2866	Carboxypeptidase
HW43_RS11025	COG0702	epimerase
HW43_RS11030	COG1073	alpha beta
HW43_RS11035	COG1073	alpha beta
HW43_RS11040	COG0583	DNA-binding transcription factor activity
HW43_RS11045	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HW43_RS11050	COG4166	transmembrane transport
HW43_RS11055	COG0668	transmembrane transport
HW43_RS11060	COG3182	Iron-regulated membrane protein
HW43_RS11065	COG0589	response to stress
HW43_RS11070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW43_RS11075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW43_RS11080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HW43_RS11090	COG1473	amidohydrolase
HW43_RS11095	COG1473	amidohydrolase
HW43_RS11100	COG0583	DNA-binding transcription factor activity
HW43_RS11105	COG2840	Smr protein MutS2
HW43_RS11110	COG3706	GGDEF domain
HW43_RS11125	COG0513	Belongs to the DEAD box helicase family
HW43_RS11135	COG0589	response to stress
HW43_RS11140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HW43_RS11145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HW43_RS11145	COG1013	pyruvate-flavodoxin oxidoreductase activity
HW43_RS11145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW43_RS11145	COG0674	pyruvate-flavodoxin oxidoreductase activity
HW43_RS11150	COG3042	response to heat
HW43_RS11155	COG3187	Heat shock protein
HW43_RS11160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW43_RS11165	COG2911	Protein conserved in bacteria
HW43_RS11175	COG3784	Protein of unknown function (DUF1318)
HW43_RS11180	COG2207	Transcriptional regulator
HW43_RS11185	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS11190	COG3733	amine oxidase
HW43_RS11195	COG2030	dehydratase
HW43_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS11200	COG3396	Phenylacetate-CoA oxygenase
HW43_RS11205	COG3460	Phenylacetate-CoA oxygenase
HW43_RS11210	COG3396	Phenylacetate-CoA oxygenase
HW43_RS11215	COG2151	metal-sulfur cluster biosynthetic enzyme
HW43_RS11220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW43_RS11225	COG1024	Enoyl-CoA hydratase
HW43_RS11230	COG1024	Enoyl-CoA hydratase
HW43_RS11235	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW43_RS11240	COG2050	protein possibly involved in aromatic compounds catabolism
HW43_RS11245	COG0183	Belongs to the thiolase family
HW43_RS11250	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HW43_RS11255	COG3327	negative regulation of DNA-templated transcription, initiation
HW43_RS11260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW43_RS11265	COG0667	Aldo Keto reductase
HW43_RS11275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW43_RS11280	COG4589	Belongs to the CDS family
HW43_RS11290	COG2453	phosphatase
HW43_RS11290	COG0671	phosphoesterase, PA-phosphatase related
HW43_RS11300	COG1643	Atp-dependent helicase
HW43_RS11305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HW43_RS11310	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS11315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW43_RS11320	COG3038	cytochrome b561
HW43_RS11335	COG0840	transmembrane signaling receptor activity
HW43_RS11340	COG0583	DNA-binding transcription factor activity
HW43_RS11345	COG5383	Protein conserved in bacteria
HW43_RS11360	COG2841	Protein conserved in bacteria
HW43_RS11365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW43_RS11370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW43_RS11375	COG1275	C4-dicarboxylate transporter malic acid transport protein
HW43_RS11380	COG0500	methyltransferase
HW43_RS11395	COG0675	Transposase, IS605 OrfB family
HW43_RS11400	COG3135	benzoate transporter
HW43_RS11405	COG1396	sequence-specific DNA binding
HW43_RS11410	COG0826	peptidase U32
HW43_RS11420	COG1724	mRNA binding
HW43_RS11425	COG1598	PFAM Uncharacterised protein family UPF0150
HW43_RS11430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HW43_RS11435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HW43_RS11440	COG3842	ATPase activity
HW43_RS11445	COG1176	ABC-type spermidine putrescine transport system, permease component I
HW43_RS11450	COG1177	transmembrane transport
HW43_RS11480	COG3238	Protein conserved in bacteria
HW43_RS11485	COG1247	-acetyltransferase
HW43_RS11490	COG2130	NADP-dependent
HW43_RS11495	COG1802	Transcriptional regulator
HW43_RS11500	COG4772	TonB-dependent receptor
HW43_RS11505	COG3391	amine dehydrogenase activity
HW43_RS11510	COG1113	amino acid transport
HW43_RS11515	COG0625	glutathione transferase activity
HW43_RS11530	COG3209	COG3209 Rhs family protein
HW43_RS11540	COG5433	transposase activity
HW43_RS11545	COG5433	transposase activity
HW43_RS11560	COG3209	COG3209 Rhs family protein
HW43_RS11580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW43_RS11585	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HW43_RS11590	COG0384	phenazine biosynthesis protein PhzF
HW43_RS11595	COG2181	nitrate reductase activity
HW43_RS11600	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HW43_RS11605	COG1140	nitrate reductase beta subunit
HW43_RS11610	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HW43_RS11615	COG2223	nitrite transmembrane transporter activity
HW43_RS11620	COG4886	Leucine-rich repeat (LRR) protein
HW43_RS11625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HW43_RS11630	COG0697	spore germination
HW43_RS11635	COG0243	molybdopterin cofactor binding
HW43_RS11635	COG3383	formate dehydrogenase (NAD+) activity
HW43_RS11640	COG0243	molybdopterin cofactor binding
HW43_RS11640	COG3383	formate dehydrogenase (NAD+) activity
HW43_RS11645	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS11650	COG2864	formate dehydrogenase
HW43_RS11655	COG3093	addiction module antidote protein HigA
HW43_RS11660	COG1064	alcohol dehydrogenase
HW43_RS11680	COG1764	response to oxidative stress
HW43_RS11685	COG4608	Belongs to the ABC transporter superfamily
HW43_RS11690	COG0444	Belongs to the ABC transporter superfamily
HW43_RS11695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW43_RS11700	COG0601	transmembrane transport
HW43_RS11705	COG0747	negative chemotaxis
HW43_RS11710	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HW43_RS11715	COG2200	EAL domain
HW43_RS11715	COG2202	Pas domain
HW43_RS11715	COG2199	diguanylate cyclase activity
HW43_RS11725	COG1649	PFAM Uncharacterised BCR, COG1649
HW43_RS11730	COG0531	amino acid
HW43_RS11735	COG0076	glutamate decarboxylase activity
HW43_RS11745	COG0612	Peptidase, M16
HW43_RS11750	COG4771	TonB-dependent receptor
HW43_RS11755	COG4178	(ABC) transporter
HW43_RS11760	COG0641	radical SAM
HW43_RS11765	COG3119	arylsulfatase activity
HW43_RS11770	COG2207	Transcriptional regulator
HW43_RS11780	COG0243	molybdopterin cofactor binding
HW43_RS11785	COG3539	Fimbrial protein
HW43_RS11790	COG3539	Fimbrial protein
HW43_RS11795	COG3539	Fimbrial protein
HW43_RS11800	COG3188	usher protein
HW43_RS11805	COG3121	Chaperone
HW43_RS11810	COG3539	Fimbrial protein
HW43_RS11815	COG4977	sequence-specific DNA binding
HW43_RS11820	COG3550	peptidyl-serine autophosphorylation
HW43_RS11825	COG1396	sequence-specific DNA binding
HW43_RS11830	COG2911	Protein conserved in bacteria
HW43_RS11830	COG3210	domain, Protein
HW43_RS11880	COG3781	membrane
HW43_RS11890	COG2199	diguanylate cyclase activity
HW43_RS11900	COG2066	Belongs to the glutaminase family
HW43_RS11905	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS11910	COG0583	DNA-binding transcription factor activity
HW43_RS11930	COG1846	Transcriptional regulator
HW43_RS11935	COG4977	sequence-specific DNA binding
HW43_RS11945	COG2723	6-phospho-beta-galactosidase activity
HW43_RS11955	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW43_RS11960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW43_RS11970	COG2188	Transcriptional regulator
HW43_RS11975	COG0697	spore germination
HW43_RS11980	COG2814	Major facilitator Superfamily
HW43_RS11990	COG3706	GGDEF domain
HW43_RS11995	COG3111	PFAM Bacterial OB fold (BOF) protein
HW43_RS12000	COG1546	Belongs to the CinA family
HW43_RS12005	COG0339	signal peptide processing
HW43_RS12010	COG4221	oxidoreductase activity
HW43_RS12015	COG1802	Transcriptional regulator
HW43_RS12025	COG0246	Mannitol dehydrogenase
HW43_RS12030	COG0477	Major facilitator Superfamily
HW43_RS12035	COG1063	alcohol dehydrogenase
HW43_RS12040	COG4948	Mandelate Racemase Muconate Lactonizing
HW43_RS12055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW43_RS12070	COG0243	molybdopterin cofactor binding
HW43_RS12075	COG0243	molybdopterin cofactor binding
HW43_RS12080	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS12085	COG3302	dmso reductase anchor subunit
HW43_RS12090	COG3381	protein complex oligomerization
HW43_RS12100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HW43_RS12105	COG1940	carbohydrate kinase activity
HW43_RS12110	COG0583	DNA-binding transcription factor activity
HW43_RS12115	COG2814	Major facilitator Superfamily
HW43_RS12130	COG3591	Belongs to the peptidase S1B family
HW43_RS12145	COG0628	permease
HW43_RS12150	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HW43_RS12155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HW43_RS12165	COG0531	amino acid
HW43_RS12175	COG3136	membrane protein required for alginate biosynthesis
HW43_RS12180	COG0745	RESPONSE REGULATOR receiver
HW43_RS12185	COG2205	protein histidine kinase activity
HW43_RS12195	COG0114	fumarate hydratase activity
HW43_RS12200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HW43_RS12200	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HW43_RS12205	COG1482	cell wall glycoprotein biosynthetic process
HW43_RS12210	COG5339	Protein conserved in bacteria
HW43_RS12225	COG3250	beta-galactosidase activity
HW43_RS12230	COG1309	transcriptional regulator
HW43_RS12235	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS12240	COG1609	Transcriptional regulator
HW43_RS12245	COG1263	PTS System
HW43_RS12245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS12250	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HW43_RS12260	COG0673	inositol 2-dehydrogenase activity
HW43_RS12300	COG4659	FMN binding
HW43_RS12310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW43_RS12320	COG3104	oligopeptide transport
HW43_RS12325	COG0625	glutathione transferase activity
HW43_RS12330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HW43_RS12345	COG3895	Periplasmic Protein
HW43_RS12355	COG3133	Outer membrane lipoprotein
HW43_RS12370	COG1566	PFAM secretion protein HlyD family protein
HW43_RS12375	COG1289	transmembrane transporter activity
HW43_RS12380	COG2032	superoxide dismutase activity
HW43_RS12385	COG4989	oxidoreductase activity
HW43_RS12390	COG3313	Fe-S protein
HW43_RS12395	COG1309	transcriptional regulator
HW43_RS12400	COG1902	pentaerythritol trinitrate reductase activity
HW43_RS12405	COG0346	lactoylglutathione lyase activity
HW43_RS12415	COG1201	RNA secondary structure unwinding
HW43_RS12420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HW43_RS12425	COG0791	NLP P60 protein
HW43_RS12430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HW43_RS12435	COG2814	Major facilitator Superfamily
HW43_RS12450	COG0583	DNA-binding transcription factor activity
HW43_RS12455	COG2814	Major facilitator Superfamily
HW43_RS12460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HW43_RS12465	COG0307	riboflavin synthase, alpha
HW43_RS12475	COG3468	outer membrane autotransporter barrel domain protein
HW43_RS12495	COG4529	Protein conserved in bacteria
HW43_RS12505	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HW43_RS12510	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS12520	COG2414	aldehyde ferredoxin oxidoreductase
HW43_RS12525	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS12535	COG0469	pyruvate kinase activity
HW43_RS12540	COG4238	major outer membrane lipoprotein
HW43_RS12545	COG1376	ErfK ybiS ycfS ynhG family protein
HW43_RS12560	COG0719	Fe-S assembly protein
HW43_RS12565	COG0396	ATPase activity
HW43_RS12570	COG0719	Fe-S assembly protein
HW43_RS12575	COG0316	Belongs to the HesB IscA family
HW43_RS12585	COG2050	protein possibly involved in aromatic compounds catabolism
HW43_RS12590	COG0247	lactate metabolic process
HW43_RS12590	COG0277	FAD linked oxidase domain protein
HW43_RS12595	COG0628	permease
HW43_RS12605	COG0738	Major facilitator superfamily
HW43_RS12610	COG2271	Major facilitator Superfamily
HW43_RS12625	COG4670	ketone body catabolic process
HW43_RS12630	COG1960	acyl-CoA dehydrogenase activity
HW43_RS12635	COG1917	Cupin 2, conserved barrel domain protein
HW43_RS12635	COG2207	Transcriptional regulator
HW43_RS12645	COG2086	electron transfer activity
HW43_RS12650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW43_RS12655	COG0644	oxidoreductase
HW43_RS12660	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HW43_RS12665	COG0318	PFAM AMP-dependent synthetase and ligase
HW43_RS12670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW43_RS12670	COG0574	Belongs to the PEP-utilizing enzyme family
HW43_RS12685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HW43_RS12690	COG4256	Hemin uptake protein
HW43_RS12705	COG0791	NLP P60 protein
HW43_RS12715	COG0386	Belongs to the glutathione peroxidase family
HW43_RS12780	COG3137	Salt-induced outer membrane protein
HW43_RS12785	COG1105	Belongs to the carbohydrate kinase PfkB family
HW43_RS12795	COG3001	Fructosamine kinase
HW43_RS12805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW43_RS12810	COG1988	membrane-bound metal-dependent
HW43_RS12815	COG1823	symporter activity
HW43_RS12830	COG0753	catalase activity
HW43_RS12840	COG1486	melibiose metabolic process
HW43_RS12845	COG2169	Transcriptional regulator
HW43_RS12845	COG1917	Cupin 2, conserved barrel domain protein
HW43_RS12850	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW43_RS12855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW43_RS12860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW43_RS12865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW43_RS12880	COG0322	excinuclease ABC activity
HW43_RS12890	COG3678	ATP-independent chaperone mediated protein folding
HW43_RS12920	COG0708	Exodeoxyribonuclease III
HW43_RS12925	COG0398	Pfam SNARE associated Golgi protein
HW43_RS12935	COG0398	Pfam SNARE associated Golgi protein
HW43_RS12940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HW43_RS12945	COG4134	Bacterial extracellular solute-binding protein
HW43_RS12950	COG4135	transport system, permease component
HW43_RS12955	COG4136	ATPase activity
HW43_RS12960	COG2897	thiosulfate sulfurtransferase activity
HW43_RS12965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW43_RS12970	COG0494	nUDIX hydrolase
HW43_RS12980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW43_RS12990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW43_RS13005	COG0778	Nitroreductase
HW43_RS13015	COG0616	signal peptide processing
HW43_RS13020	COG0252	asparaginase activity
HW43_RS13025	COG1335	isochorismatase
HW43_RS13030	COG2814	Major facilitator Superfamily
HW43_RS13035	COG1349	DNA-binding transcription factor activity
HW43_RS13040	COG0667	Aldo Keto reductase
HW43_RS13045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW43_RS13050	COG0191	fructose-bisphosphate aldolase activity
HW43_RS13055	COG1063	alcohol dehydrogenase
HW43_RS13060	COG2271	Major facilitator Superfamily
HW43_RS13065	COG1063	alcohol dehydrogenase
HW43_RS13070	COG3139	Protein of unknown function (DUF1315)
HW43_RS13080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW43_RS13085	COG0676	glucose-6-phosphate 1-epimerase activity
HW43_RS13090	COG0656	L-ascorbic acid biosynthetic process
HW43_RS13095	COG3713	MltA-interacting MipA family protein
HW43_RS13100	COG2766	serine protein kinase
HW43_RS13110	COG2199	diguanylate cyclase activity
HW43_RS13115	COG2199	diguanylate cyclase activity
HW43_RS13120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HW43_RS13135	COG2207	Transcriptional regulator
HW43_RS13140	COG2807	transmembrane transport
HW43_RS13145	COG3189	MarR family transcriptional regulator
HW43_RS13150	COG3042	response to heat
HW43_RS13155	COG2199	diguanylate cyclase activity
HW43_RS13155	COG2203	Gaf domain
HW43_RS13165	COG2261	transglycosylase associated protein
HW43_RS13170	COG0675	Transposase, IS605 OrfB family
HW43_RS13185	COG3615	Tellurite resistance protein tehB
HW43_RS13195	COG0583	DNA-binding transcription factor activity
HW43_RS13200	COG0473	3-isopropylmalate dehydrogenase activity
HW43_RS13205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW43_RS13210	COG4638	Rieske (2fe-2S)
HW43_RS13215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW43_RS13220	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HW43_RS13225	COG0318	PFAM AMP-dependent synthetase and ligase
HW43_RS13230	COG3065	identical protein binding
HW43_RS13235	COG1214	PFAM Peptidase M22, glycoprotease
HW43_RS13240	COG1199	ATP-dependent helicase activity
HW43_RS13245	COG0251	oxidation-reduction process
HW43_RS13260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW43_RS13270	COG1760	l-serine dehydratase
HW43_RS13275	COG2200	EAL domain
HW43_RS13280	COG1253	flavin adenine dinucleotide binding
HW43_RS13290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS13290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS13295	COG3715	PTS system
HW43_RS13300	COG3716	PTS system mannose fructose sorbose family IID component
HW43_RS13320	COG2226	methyltransferase
HW43_RS13355	COG1414	Transcriptional regulator
HW43_RS13360	COG2814	Major facilitator Superfamily
HW43_RS13370	COG0793	Belongs to the peptidase S41A family
HW43_RS13380	COG1956	GAF domain-containing protein
HW43_RS13385	COG2995	paraquat-inducible protein a
HW43_RS13390	COG3008	intermembrane lipid transfer
HW43_RS13410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW43_RS13425	COG1276	copper resistance
HW43_RS13430	COG2372	response to copper ion
HW43_RS13445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW43_RS13450	COG1770	oligopeptidase
HW43_RS13455	COG2979	Protein of unknown function (DUF533)
HW43_RS13470	COG3141	response to X-ray
HW43_RS13480	COG0800	Aldolase
HW43_RS13485	COG0129	dihydroxy-acid dehydratase activity
HW43_RS13490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW43_RS13500	COG1737	Transcriptional regulator
HW43_RS13505	COG0469	pyruvate kinase activity
HW43_RS13530	COG3833	ABC-type maltose transport systems, permease component
HW43_RS13535	COG1175	transmembrane transport
HW43_RS13540	COG2182	Extracellular solute-binding protein
HW43_RS13550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HW43_RS13560	COG3842	ATPase activity
HW43_RS13580	COG1560	Kdo2-lipid A biosynthetic process
HW43_RS13585	COG0739	heme binding
HW43_RS13590	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HW43_RS13600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW43_RS13625	COG0217	transcriptional regulatory protein
HW43_RS13630	COG0494	nUDIX hydrolase
HW43_RS13640	COG1335	isochorismatase
HW43_RS13645	COG1801	Protein of unknown function DUF72
HW43_RS13650	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HW43_RS13665	COG0243	molybdopterin cofactor binding
HW43_RS13670	COG3005	denitrification pathway
HW43_RS13680	COG3102	Protein conserved in bacteria
HW43_RS13690	COG3755	Protein conserved in bacteria
HW43_RS13700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW43_RS13705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW43_RS13710	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HW43_RS13715	COG0745	RESPONSE REGULATOR receiver
HW43_RS13720	COG2201	protein-glutamate methylesterase activity
HW43_RS13725	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW43_RS13730	COG0840	transmembrane signaling receptor activity
HW43_RS13735	COG0840	transmembrane signaling receptor activity
HW43_RS13740	COG0835	chemotaxis
HW43_RS13745	COG2198	Histidine kinase
HW43_RS13745	COG0643	Histidine kinase
HW43_RS13750	COG1360	Flagellar Motor Protein
HW43_RS13755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW43_RS13770	COG0589	response to stress
HW43_RS13780	COG1877	trehalose-phosphatase activity
HW43_RS13785	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW43_RS13790	COG1129	ABC transporter
HW43_RS13795	COG1879	ABC-type sugar transport system periplasmic component
HW43_RS13800	COG1528	Iron-storage protein
HW43_RS13825	COG1528	Iron-storage protein
HW43_RS13835	COG0814	amino acid
HW43_RS13840	COG3318	Belongs to the UPF0149 family
HW43_RS13840	COG3012	SEC-C Motif Domain Protein
HW43_RS13870	COG2197	response regulator
HW43_RS13885	COG2197	response regulator
HW43_RS13890	COG1126	abc transporter atp-binding protein
HW43_RS13895	COG0765	amino acid transport
HW43_RS13905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS13915	COG1191	sigma factor activity
HW43_RS13930	COG1516	flagellar protein fliS
HW43_RS13940	COG0366	Alpha amylase catalytic
HW43_RS13950	COG2391	methyltransferase activity
HW43_RS13955	COG0425	Belongs to the sulfur carrier protein TusA family
HW43_RS13960	COG2135	peptidase activity
HW43_RS13975	COG1766	The M ring may be actively involved in energy transduction
HW43_RS13980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW43_RS13985	COG1317	bacterial-type flagellum organization
HW43_RS13990	COG1157	protein secretion by the type III secretion system
HW43_RS13995	COG2882	bacterial-type flagellum organization
HW43_RS14000	COG3144	bacterial-type flagellum assembly
HW43_RS14005	COG1580	Controls the rotational direction of flagella during chemotaxis
HW43_RS14010	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW43_RS14015	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW43_RS14020	COG3190	flagellar
HW43_RS14025	COG1338	Plays a role in the flagellum-specific transport system
HW43_RS14030	COG1987	bacterial-type flagellum assembly
HW43_RS14035	COG1684	flagellar biosynthetic protein fliR
HW43_RS14040	COG2197	response regulator
HW43_RS14060	COG3706	GGDEF domain
HW43_RS14065	COG5475	Uncharacterized small protein (DUF2158)
HW43_RS14070	COG2354	Protein conserved in bacteria
HW43_RS14075	COG0697	spore germination
HW43_RS14080	COG3727	T/G mismatch-specific endonuclease activity
HW43_RS14085	COG0270	DNA (cytosine-5-)-methyltransferase activity
HW43_RS14090	COG1418	mRNA catabolic process
HW43_RS14105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HW43_RS14120	COG2205	protein histidine kinase activity
HW43_RS14125	COG0745	RESPONSE REGULATOR receiver
HW43_RS14130	COG2351	hydroxyisourate hydrolase activity
HW43_RS14145	COG3443	Belongs to the bacterial solute-binding protein 9 family
HW43_RS14150	COG3038	cytochrome b561
HW43_RS14185	COG1388	LysM domain
HW43_RS14185	COG1470	cell adhesion involved in biofilm formation
HW43_RS14190	COG1388	LysM domain
HW43_RS14190	COG1470	cell adhesion involved in biofilm formation
HW43_RS14200	COG0477	Major facilitator Superfamily
HW43_RS14205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW43_RS14210	COG0217	transcriptional regulatory protein
HW43_RS14220	COG0534	Mate efflux family protein
HW43_RS14230	COG0582	viral genome integration into host DNA
HW43_RS14235	COG0582	viral genome integration into host DNA
HW43_RS14245	COG5290	Psort location Cytoplasmic, score
HW43_RS14260	COG0583	DNA-binding transcription factor activity
HW43_RS14265	COG0583	DNA-binding transcription factor activity
HW43_RS14275	COG1376	ErfK ybiS ycfS ynhG family protein
HW43_RS14290	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HW43_RS14350	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HW43_RS14365	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HW43_RS14380	COG1454	alcohol dehydrogenase
HW43_RS14380	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS14385	COG4656	Part of a membrane complex involved in electron transport
HW43_RS14410	COG1289	transmembrane transporter activity
HW43_RS14420	COG1686	Belongs to the peptidase S11 family
HW43_RS14425	COG2925	Exonuclease
HW43_RS14430	COG0425	Belongs to the sulfur carrier protein TusA family
HW43_RS14435	COG2391	methyltransferase activity
HW43_RS14440	COG0531	amino acid
HW43_RS14445	COG0583	DNA-binding transcription factor activity
HW43_RS14450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW43_RS14455	COG4115	mRNA cleavage
HW43_RS14460	COG2161	toxin-antitoxin pair type II binding
HW43_RS14480	COG0131	Imidazoleglycerol-phosphate dehydratase
HW43_RS14480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HW43_RS14485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HW43_RS14500	COG0140	phosphoribosyl-ATP diphosphatase activity
HW43_RS14500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HW43_RS14505	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HW43_RS14510	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW43_RS14515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HW43_RS14555	COG2089	acid synthase
HW43_RS14565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW43_RS14570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW43_RS14580	COG0438	transferase activity, transferring glycosyl groups
HW43_RS14585	COG2327	Polysaccharide pyruvyl transferase
HW43_RS14590	COG2244	polysaccharide biosynthetic process
HW43_RS14595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HW43_RS14600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW43_RS14605	COG0662	Cupin 2, conserved barrel domain protein
HW43_RS14605	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HW43_RS14610	COG0297	glycogen (starch) synthase activity
HW43_RS14615	COG1051	belongs to the nudix hydrolase family
HW43_RS14620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HW43_RS14625	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HW43_RS14630	COG0110	maltose O-acetyltransferase activity
HW43_RS14635	COG1216	Glycosyl transferase, family 2
HW43_RS14645	COG0438	transferase activity, transferring glycosyl groups
HW43_RS14650	COG1045	serine acetyltransferase
HW43_RS14655	COG0463	Glycosyl transferase, family 2
HW43_RS14660	COG3206	protein involved in exopolysaccharide biosynthesis
HW43_RS14660	COG0489	protein tyrosine kinase activity
HW43_RS14665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW43_RS14670	COG1596	polysaccharide export
HW43_RS14675	COG1253	flavin adenine dinucleotide binding
HW43_RS14680	COG2982	Protein involved in outer membrane biogenesis
HW43_RS14690	COG0572	uridine kinase
HW43_RS14695	COG5001	Diguanylate cyclase
HW43_RS14695	COG3447	MASE1 domain protein
HW43_RS14695	COG5002	protein histidine kinase activity
HW43_RS14700	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HW43_RS14705	COG0443	Heat shock 70 kDa protein
HW43_RS14710	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HW43_RS14715	COG0631	protein serine/threonine phosphatase activity
HW43_RS14720	COG4245	von Willebrand factor, type A
HW43_RS14745	COG2205	protein histidine kinase activity
HW43_RS14750	COG0745	RESPONSE REGULATOR receiver
HW43_RS14760	COG3609	addiction module antidote protein, CC2985 family
HW43_RS14770	COG0826	peptidase U32
HW43_RS14795	COG1063	alcohol dehydrogenase
HW43_RS14800	COG3775	system Galactitol-specific IIC component
HW43_RS14805	COG3414	Phosphotransferase system galactitol-specific IIB component
HW43_RS14810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS14825	COG1830	Aldolase
HW43_RS14830	COG2211	Major facilitator Superfamily
HW43_RS14835	COG1397	ADP-ribosylglycohydrolase
HW43_RS14840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW43_RS14845	COG2188	Transcriptional regulator
HW43_RS14850	COG3757	hydrolase, family 25
HW43_RS14855	COG0351	phosphomethylpyrimidine kinase
HW43_RS14915	COG5455	response to cobalt ion
HW43_RS14920	COG3539	Fimbrial protein
HW43_RS14925	COG3188	usher protein
HW43_RS14930	COG3121	Chaperone
HW43_RS14935	COG3539	Fimbrial protein
HW43_RS14950	COG0489	protein tyrosine kinase activity
HW43_RS14960	COG3831	ATPase activity
HW43_RS14965	COG3831	ATPase activity
HW43_RS14985	COG0714	Associated with various cellular activities
HW43_RS14990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HW43_RS14995	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HW43_RS15005	COG4808	Protein conserved in bacteria
HW43_RS15010	COG4807	Protein conserved in bacteria
HW43_RS15015	COG3279	Response regulator of the LytR AlgR family
HW43_RS15020	COG3275	phosphorelay sensor kinase activity
HW43_RS15145	COG4220	transposase activity
HW43_RS15155	COG3646	Phage regulatory protein
HW43_RS15175	COG3772	lysozyme
HW43_RS15250	COG1403	HNH endonuclease
HW43_RS15260	COG0305	Participates in initiation and elongation during chromosome replication
HW43_RS15265	COG1484	DNA-dependent DNA replication
HW43_RS15285	COG3646	Phage regulatory protein
HW43_RS15305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW43_RS15350	COG0582	viral genome integration into host DNA
HW43_RS15355	COG0789	Transcriptional regulator
HW43_RS15365	COG1174	glycine betaine transport
HW43_RS15370	COG1125	glycine betaine transport
HW43_RS15375	COG1174	glycine betaine transport
HW43_RS15380	COG1732	Glycine betaine
HW43_RS15385	COG1472	Belongs to the glycosyl hydrolase 3 family
HW43_RS15390	COG0277	FAD linked oxidase domain protein
HW43_RS15395	COG1686	Belongs to the peptidase S11 family
HW43_RS15405	COG0586	Pfam SNARE associated Golgi protein
HW43_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS15425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW43_RS15435	COG1346	cytolysis
HW43_RS15445	COG2949	membrane
HW43_RS15455	COG0493	'glutamate synthase
HW43_RS15460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HW43_RS15460	COG0167	dihydroorotate dehydrogenase activity
HW43_RS15465	COG4211	Belongs to the binding-protein-dependent transport system permease family
HW43_RS15470	COG1129	ABC transporter
HW43_RS15475	COG1879	ABC-type sugar transport system periplasmic component
HW43_RS15480	COG1609	Transcriptional regulator
HW43_RS15490	COG2311	Membrane
HW43_RS15520	COG0833	amino acid
HW43_RS15525	COG0583	DNA-binding transcription factor activity
HW43_RS15530	COG2855	membrane
HW43_RS15540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW43_RS15540	COG1522	sequence-specific DNA binding
HW43_RS15545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW43_RS15555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW43_RS15560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW43_RS15565	COG2313	pseudouridylate synthase activity
HW43_RS15570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW43_RS15575	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HW43_RS15575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS15575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS15580	COG1105	Belongs to the carbohydrate kinase PfkB family
HW43_RS15585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS15585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS15590	COG2814	Major facilitator Superfamily
HW43_RS15605	COG0246	Mannitol dehydrogenase
HW43_RS15610	COG0523	cobalamin synthesis protein
HW43_RS15615	COG0671	phosphoesterase, PA-phosphatase related
HW43_RS15620	COG0791	NLP P60 protein
HW43_RS15625	COG2200	EAL domain
HW43_RS15630	COG4166	transmembrane transport
HW43_RS15635	COG4174	ABC transporter (Permease)
HW43_RS15640	COG4239	(ABC) transporter, permease
HW43_RS15645	COG4172	Belongs to the ABC transporter superfamily
HW43_RS15655	COG2814	Major facilitator Superfamily
HW43_RS15660	COG1187	pseudouridine synthase activity
HW43_RS15665	COG1061	Type III restriction enzyme res subunit
HW43_RS15685	COG3083	sulfuric ester hydrolase activity
HW43_RS15695	COG3468	outer membrane autotransporter barrel domain protein
HW43_RS15700	COG3468	outer membrane autotransporter barrel domain protein
HW43_RS15710	COG2197	response regulator
HW43_RS15715	COG4235	cytochrome complex assembly
HW43_RS15715	COG3088	subunit of a heme lyase
HW43_RS15720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW43_RS15725	COG1138	Cytochrome C-type biogenesis protein
HW43_RS15735	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW43_RS15740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW43_RS15745	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW43_RS15750	COG4133	protoheme IX ABC transporter activity
HW43_RS15755	COG3005	denitrification pathway
HW43_RS15760	COG3043	anaerobic respiration
HW43_RS15765	COG0348	domain, Protein
HW43_RS15770	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS15780	COG3062	negative regulation of establishment of protein localization
HW43_RS15785	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS15785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS15805	COG4615	Cyclic peptide transporter
HW43_RS15810	COG3145	DNA-N1-methyladenine dioxygenase activity
HW43_RS15815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW43_RS15815	COG2169	Transcriptional regulator
HW43_RS15820	COG1477	protein flavinylation
HW43_RS15825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HW43_RS15840	COG2198	Histidine kinase
HW43_RS15840	COG0642	Histidine kinase
HW43_RS15845	COG2197	response regulator
HW43_RS15850	COG0784	Response regulator, receiver
HW43_RS15850	COG2205	protein histidine kinase activity
HW43_RS15855	COG4676	Protein conserved in bacteria
HW43_RS15860	COG5445	Predicted secreted protein (DUF2300)
HW43_RS15865	COG2373	Large extracellular alpha-helical protein
HW43_RS15870	COG3234	Protein of unknown function (DUF1175)
HW43_RS15875	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HW43_RS15880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW43_RS15890	COG3468	outer membrane autotransporter barrel domain protein
HW43_RS15900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW43_RS15905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW43_RS15910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW43_RS15915	COG3642	lipopolysaccharide core region biosynthetic process
HW43_RS15920	COG0583	DNA-binding transcription factor activity
HW43_RS15925	COG0584	glycerophosphoryl diester phosphodiesterase
HW43_RS15930	COG2271	Major facilitator Superfamily
HW43_RS15935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW43_RS15945	COG0247	lactate metabolic process
HW43_RS15950	COG5464	transposase or invertase
HW43_RS16020	COG0318	PFAM AMP-dependent synthetase and ligase
HW43_RS16030	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW43_RS16045	COG1169	isochorismate synthase
HW43_RS16050	COG4575	ribosome binding
HW43_RS16055	COG2153	protein acetylation
HW43_RS16070	COG2234	aminopeptidase activity
HW43_RS16085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW43_RS16090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW43_RS16100	COG0839	Belongs to the complex I subunit 6 family
HW43_RS16115	COG1034	ATP synthesis coupled electron transport
HW43_RS16120	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HW43_RS16125	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HW43_RS16145	COG0583	DNA-binding transcription factor activity
HW43_RS16150	COG0436	Aminotransferase
HW43_RS16160	COG0490	domain, Protein
HW43_RS16160	COG0471	metal ion transport
HW43_RS16165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW43_RS16185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW43_RS16190	COG0280	phosphate acetyltransferase
HW43_RS16190	COG0857	belongs to the CobB CobQ family
HW43_RS16195	COG1288	antiporter activity
HW43_RS16200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HW43_RS16205	COG0622	Phosphoesterase
HW43_RS16210	COG0625	glutathione transferase activity
HW43_RS16215	COG0625	glutathione transferase activity
HW43_RS16220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW43_RS16225	COG1090	epimerase
HW43_RS16230	COG5464	transposase or invertase
HW43_RS16235	COG4598	ABC transporter
HW43_RS16240	COG4160	amino acid transport
HW43_RS16245	COG4215	(ABC) transporter
HW43_RS16250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS16255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS16260	COG0163	prenyltransferase activity
HW43_RS16265	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW43_RS16270	COG1286	toxin biosynthetic process
HW43_RS16275	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HW43_RS16280	COG0285	dihydrofolate synthase activity
HW43_RS16290	COG0586	Pfam SNARE associated Golgi protein
HW43_RS16300	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW43_RS16310	COG4974	Belongs to the 'phage' integrase family
HW43_RS16395	COG4695	Portal protein
HW43_RS16475	COG5301	cellulose 1,4-beta-cellobiosidase activity
HW43_RS16475	COG5301	cellulose 1,4-beta-cellobiosidase activity
HW43_RS16480	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HW43_RS16485	COG0859	PFAM glycosyl transferase family 9
HW43_RS16555	COG2814	Major facilitator Superfamily
HW43_RS16560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW43_RS16575	COG3101	peptidyl-lysine hydroxylation
HW43_RS16580	COG0730	response to heat
HW43_RS16595	COG2890	protein-(glutamine-N5) methyltransferase activity
HW43_RS16610	COG3539	Fimbrial protein
HW43_RS16615	COG3539	Fimbrial protein
HW43_RS16620	COG3539	Fimbrial protein
HW43_RS16625	COG3121	Chaperone
HW43_RS16630	COG3188	usher protein
HW43_RS16635	COG3539	Fimbrial protein
HW43_RS16640	COG2062	phosphohistidine phosphatase, SixA
HW43_RS16655	COG3691	Protein conserved in bacteria
HW43_RS16660	COG2067	long-chain fatty acid transport protein
HW43_RS16670	COG2853	Lipoprotein
HW43_RS16675	COG2116	formate transmembrane transporter activity
HW43_RS16705	COG2610	gluconate transmembrane transporter activity
HW43_RS16715	COG0477	Major facilitator Superfamily
HW43_RS16720	COG1566	PFAM secretion protein HlyD family protein
HW43_RS16725	COG2197	response regulator
HW43_RS16730	COG0784	Response regulator, receiver
HW43_RS16730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS16730	COG2198	Histidine kinase
HW43_RS16730	COG2205	protein histidine kinase activity
HW43_RS16735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HW43_RS16740	COG0679	Auxin Efflux Carrier
HW43_RS16745	COG0028	Belongs to the TPP enzyme family
HW43_RS16775	COG1560	Kdo2-lipid A biosynthetic process
HW43_RS16780	COG0436	Aminotransferase
HW43_RS16785	COG3275	phosphorelay sensor kinase activity
HW43_RS16790	COG3279	Response regulator of the LytR AlgR family
HW43_RS16795	COG2207	Transcriptional regulator
HW43_RS16805	COG1363	Peptidase, m42
HW43_RS16810	COG0006	proline dipeptidase activity
HW43_RS16815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS16820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW43_RS16850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW43_RS16855	COG2199	diguanylate cyclase activity
HW43_RS16855	COG2200	EAL domain
HW43_RS16870	COG3415	Transposase
HW43_RS16875	COG3415	Transposase
HW43_RS16905	COG0583	DNA-binding transcription factor activity
HW43_RS16915	COG2211	Major facilitator Superfamily
HW43_RS16920	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HW43_RS16930	COG0583	DNA-binding transcription factor activity
HW43_RS16935	COG0385	Bile acid
HW43_RS16940	COG3530	Putative quorum-sensing-regulated virulence factor
HW43_RS16960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW43_RS16965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS16970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW43_RS16975	COG2190	(PTS) system
HW43_RS16990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW43_RS16995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HW43_RS17000	COG4208	sulfate ABC transporter
HW43_RS17005	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HW43_RS17010	COG4150	thiosulfate binding
HW43_RS17015	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS17030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS17030	COG1263	PTS System
HW43_RS17035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW43_RS17040	COG2837	iron assimilation
HW43_RS17060	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW43_RS17070	COG2207	Transcriptional regulator
HW43_RS17075	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HW43_RS17080	COG4816	utilization protein
HW43_RS17090	COG4303	Ethanolamine ammonia lyase large subunit
HW43_RS17095	COG4819	ethanolamine utilization protein
HW43_RS17100	COG3192	ethanolamine utilization protein
HW43_RS17105	COG1454	alcohol dehydrogenase
HW43_RS17110	COG4820	ethanolamine utilization protein (EutJ)
HW43_RS17115	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS17120	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HW43_RS17125	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HW43_RS17130	COG0280	phosphate acetyltransferase
HW43_RS17135	COG4812	Cobalamin adenosyltransferase
HW43_RS17140	COG4766	ethanolamine catabolic process
HW43_RS17145	COG4917	ethanolamine utilization protein
HW43_RS17150	COG4810	utilization protein
HW43_RS17155	COG0281	malic enzyme
HW43_RS17155	COG0280	phosphate acetyltransferase
HW43_RS17160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW43_RS17165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HW43_RS17170	COG5342	invasion associated locus B
HW43_RS17180	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS17180	COG0493	'glutamate synthase
HW43_RS17185	COG3850	Histidine kinase
HW43_RS17190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW43_RS17200	COG1393	Belongs to the ArsC family
HW43_RS17215	COG0400	carboxylic ester hydrolase activity
HW43_RS17225	COG2321	neutral zinc metallopeptidase
HW43_RS17250	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HW43_RS17260	COG2716	regulation of RNA biosynthetic process
HW43_RS17265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW43_RS17270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS17275	COG0651	ATP synthesis coupled electron transport
HW43_RS17280	COG0651	ATP synthesis coupled electron transport
HW43_RS17285	COG0650	Formate hydrogenlyase subunit 4
HW43_RS17290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW43_RS17295	COG4237	Hydrogenase 4 membrane
HW43_RS17300	COG0651	ATP synthesis coupled electron transport
HW43_RS17310	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HW43_RS17310	COG3261	NADH dehydrogenase
HW43_RS17315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW43_RS17320	COG3260	NADH ubiquinone oxidoreductase 20
HW43_RS17330	COG3604	Transcriptional regulator
HW43_RS17335	COG2116	formate transmembrane transporter activity
HW43_RS17340	COG0628	permease
HW43_RS17345	COG4783	chaperone-mediated protein folding
HW43_RS17350	COG1393	Belongs to the ArsC family
HW43_RS17360	COG2233	PERMEase
HW43_RS17375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW43_RS17380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HW43_RS17385	COG0248	Ppx GppA phosphatase
HW43_RS17390	COG2200	EAL domain
HW43_RS17405	COG3133	Outer membrane lipoprotein
HW43_RS17420	COG0517	IMP dehydrogenase activity
HW43_RS17420	COG0516	GMP reductase activity
HW43_RS17430	COG1645	bacterial-type flagellum-dependent swarming motility
HW43_RS17445	COG2976	Protein conserved in bacteria
HW43_RS17475	COG4953	penicillin-binding protein 1C
HW43_RS17480	COG2373	Large extracellular alpha-helical protein
HW43_RS17485	COG2897	thiosulfate sulfurtransferase activity
HW43_RS17500	COG2975	iron-sulfur cluster assembly
HW43_RS17505	COG0633	Ferredoxin
HW43_RS17525	COG0822	iron-sulfur transferase activity
HW43_RS17545	COG0483	inositol monophosphate 1-phosphatase activity
HW43_RS17550	COG1073	alpha beta
HW43_RS17555	COG3711	transcriptional antiterminator
HW43_RS17560	COG2814	Major facilitator Superfamily
HW43_RS17565	COG0583	DNA-binding transcription factor activity
HW43_RS17570	COG4638	Rieske (2fe-2S)
HW43_RS17595	COG2259	Doxx family
HW43_RS17600	COG2017	converts alpha-aldose to the beta-anomer
HW43_RS17605	COG1063	alcohol dehydrogenase
HW43_RS17610	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW43_RS17615	COG1129	ABC transporter
HW43_RS17620	COG1879	ABC-type sugar transport system periplasmic component
HW43_RS17625	COG0457	Tetratricopeptide repeat
HW43_RS17630	COG1940	carbohydrate kinase activity
HW43_RS17640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HW43_RS17640	COG1017	nitric oxide dioxygenase activity
HW43_RS17645	COG0347	Belongs to the P(II) protein family
HW43_RS17650	COG2204	response regulator
HW43_RS17655	COG3170	Tfp pilus assembly protein FimV
HW43_RS17660	COG2205	protein histidine kinase activity
HW43_RS17680	COG0560	Phosphoserine phosphatase
HW43_RS17685	COG1737	Transcriptional regulator
HW43_RS17690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS17715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HW43_RS17735	COG0681	Belongs to the peptidase S26 family
HW43_RS17745	COG3086	response to oxidative stress
HW43_RS17750	COG3026	antisigma factor binding
HW43_RS17755	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HW43_RS17760	COG1595	DNA-templated transcription, initiation
HW43_RS17770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HW43_RS17780	COG0513	Belongs to the DEAD box helicase family
HW43_RS17790	COG0583	DNA-binding transcription factor activity
HW43_RS17810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW43_RS17820	COG3118	belongs to the thioredoxin family
HW43_RS17825	COG3148	PFAM DTW domain containing protein
HW43_RS17830	COG1042	CoA-binding domain protein
HW43_RS17830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW43_RS17830	COG0045	succinate-CoA ligase (ADP-forming) activity
HW43_RS17835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW43_RS17840	COG5544	Lipoprotein
HW43_RS17845	COG0477	Major facilitator Superfamily
HW43_RS17875	COG0542	response to heat
HW43_RS17880	COG1496	oxidoreductase activity
HW43_RS17885	COG0564	pseudouridine synthase activity
HW43_RS17890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW43_RS17900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HW43_RS17905	COG0077	Prephenate dehydratase
HW43_RS17905	COG1605	Chorismate mutase
HW43_RS17910	COG1605	Chorismate mutase
HW43_RS17910	COG0287	Prephenate dehydrogenase
HW43_RS17915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HW43_RS17930	COG2199	diguanylate cyclase activity
HW43_RS17935	COG2885	chlorophyll binding
HW43_RS17960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW43_RS17965	COG4137	Cytochrome C assembly protein
HW43_RS17970	COG4536	flavin adenine dinucleotide binding
HW43_RS17990	COG0497	DNA recombination
HW43_RS17995	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HW43_RS18005	COG2867	negative regulation of translational initiation
HW43_RS18015	COG0582	viral genome integration into host DNA
HW43_RS18035	COG2801	Transposase and inactivated derivatives
HW43_RS18045	COG0366	Alpha amylase catalytic
HW43_RS18050	COG0366	Alpha amylase catalytic
HW43_RS18060	COG0579	oxidoreductase
HW43_RS18065	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS18070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HW43_RS18075	COG1113	amino acid transport
HW43_RS18080	COG1802	Transcriptional regulator
HW43_RS18085	COG1652	LysM domain
HW43_RS18090	COG0401	homolog of Blt101
HW43_RS18095	COG0640	Transcriptional regulator
HW43_RS18100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW43_RS18105	COG2916	Histone family protein nucleoid-structuring protein H-NS
HW43_RS18120	COG4575	ribosome binding
HW43_RS18125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HW43_RS18135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW43_RS18140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW43_RS18145	COG4175	Glycine betaine
HW43_RS18150	COG4176	ABC-type proline glycine betaine transport system permease component
HW43_RS18155	COG2113	Glycine betaine
HW43_RS18160	COG2814	Major facilitator Superfamily
HW43_RS18165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HW43_RS18175	COG1846	Transcriptional regulator
HW43_RS18180	COG1566	PFAM secretion protein HlyD family protein
HW43_RS18185	COG2814	Major facilitator Superfamily
HW43_RS18200	COG1238	metal cluster binding
HW43_RS18205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HW43_RS18235	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HW43_RS18260	COG1546	Belongs to the CinA family
HW43_RS18265	COG2951	lytic endotransglycosylase activity
HW43_RS18270	COG3730	PTS system glucitol sorbitol-specific
HW43_RS18275	COG3732	PTS system glucitol sorbitol-specific
HW43_RS18285	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS18290	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS18295	COG1349	DNA-binding transcription factor activity
HW43_RS18320	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HW43_RS18325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS18330	COG1609	Transcriptional regulator
HW43_RS18335	COG1263	PTS System
HW43_RS18335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS18340	COG2723	6-phospho-beta-galactosidase activity
HW43_RS18345	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HW43_RS18355	COG3260	NADH ubiquinone oxidoreductase 20
HW43_RS18360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW43_RS18365	COG3261	NADH dehydrogenase
HW43_RS18365	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HW43_RS18370	COG0650	Formate hydrogenlyase subunit 4
HW43_RS18375	COG0651	ATP synthesis coupled electron transport
HW43_RS18380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS18395	COG0375	protein maturation
HW43_RS18400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HW43_RS18405	COG0298	carbon dioxide binding
HW43_RS18410	COG0409	Hydrogenase expression formation protein
HW43_RS18415	COG0309	Hydrogenase expression formation protein (HypE)
HW43_RS18420	COG3604	Transcriptional regulator
HW43_RS18440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW43_RS18445	COG1349	DNA-binding transcription factor activity
HW43_RS18450	COG2084	Dehydrogenase
HW43_RS18455	COG3395	kinase activity
HW43_RS18460	COG0235	Class ii aldolase
HW43_RS18465	COG3622	Belongs to the hyi family
HW43_RS18470	COG2610	gluconate transmembrane transporter activity
HW43_RS18480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HW43_RS18495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW43_RS18500	COG4942	peptidase
HW43_RS18500	COG1388	LysM domain
HW43_RS18555	COG2234	aminopeptidase activity
HW43_RS18560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW43_RS18565	COG1518	maintenance of DNA repeat elements
HW43_RS18580	COG1857	crispr-associated protein
HW43_RS18595	COG1203	CRISPR-associated helicase, Cas3
HW43_RS18620	COG0720	synthase
HW43_RS18625	COG0644	oxidoreductase
HW43_RS18630	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HW43_RS18635	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HW43_RS18640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW43_RS18645	COG2086	electron transfer activity
HW43_RS18650	COG0477	Major facilitator Superfamily
HW43_RS18655	COG0277	FAD linked oxidase domain protein
HW43_RS18660	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS18665	COG2223	nitrite transmembrane transporter activity
HW43_RS18670	COG1070	Carbohydrate kinase
HW43_RS18675	COG0602	queuosine metabolic process
HW43_RS18685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HW43_RS18700	COG3956	TIGRFAM MazG family protein
HW43_RS18705	COG2337	Toxic component of a toxin-antitoxin (TA) module
HW43_RS18710	COG2336	PFAM SpoVT AbrB
HW43_RS18715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW43_RS18725	COG2205	protein histidine kinase activity
HW43_RS18725	COG3437	response regulator, receiver
HW43_RS18725	COG4999	Histidine kinase
HW43_RS18725	COG3850	Histidine kinase
HW43_RS18730	COG4948	Mandelate Racemase Muconate Lactonizing
HW43_RS18735	COG4948	Mandelate Racemase Muconate Lactonizing
HW43_RS18740	COG2271	Major facilitator Superfamily
HW43_RS18745	COG0716	FMN binding
HW43_RS18750	COG0564	pseudouridine synthase activity
HW43_RS18755	COG3098	single-species biofilm formation
HW43_RS18775	COG1611	Belongs to the LOG family
HW43_RS18780	COG0814	amino acid
HW43_RS18785	COG1760	l-serine dehydratase
HW43_RS18795	COG1454	alcohol dehydrogenase
HW43_RS18800	COG0235	Class ii aldolase
HW43_RS18805	COG0738	Major facilitator superfamily
HW43_RS18815	COG1070	Carbohydrate kinase
HW43_RS18825	COG1349	DNA-binding transcription factor activity
HW43_RS18835	COG2363	Small membrane protein
HW43_RS18840	COG0583	DNA-binding transcription factor activity
HW43_RS18850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW43_RS18855	COG2166	iron-sulfur cluster assembly
HW43_RS18860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW43_RS18865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HW43_RS18905	COG2885	chlorophyll binding
HW43_RS19005	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW43_RS19010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HW43_RS19010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HW43_RS19015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW43_RS19020	COG1074	ATP-dependent DNA helicase activity
HW43_RS19025	COG1025	Belongs to the peptidase M16 family
HW43_RS19030	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HW43_RS19035	COG4967	type IV pilus modification protein PilV
HW43_RS19045	COG4795	General secretion pathway protein
HW43_RS19050	COG2165	general secretion pathway protein
HW43_RS19065	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HW43_RS19090	COG0861	Integral membrane protein TerC family
HW43_RS19100	COG0667	Aldo Keto reductase
HW43_RS19115	COG1609	Transcriptional regulator
HW43_RS19125	COG0583	DNA-binding transcription factor activity
HW43_RS19130	COG1794	racemase activity, acting on amino acids and derivatives
HW43_RS19135	COG2814	Major facilitator Superfamily
HW43_RS19140	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS19150	COG0183	Belongs to the thiolase family
HW43_RS19155	COG0814	amino acid
HW43_RS19160	COG2771	luxR family
HW43_RS19165	COG3710	Transcriptional regulator
HW43_RS19180	COG0457	Tetratricopeptide repeat
HW43_RS19185	COG0457	Tetratricopeptide repeat
HW43_RS19185	COG3710	Transcriptional regulator
HW43_RS19200	COG2197	response regulator
HW43_RS19205	COG2197	response regulator
HW43_RS19290	COG3387	PFAM Glycoside hydrolase 15-related
HW43_RS19300	COG4942	peptidase
HW43_RS19305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW43_RS19310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HW43_RS19315	COG2080	2 iron, 2 sulfur cluster binding
HW43_RS19320	COG3829	transcription factor binding
HW43_RS19325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW43_RS19330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW43_RS19335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW43_RS19345	COG0549	Belongs to the carbamate kinase family
HW43_RS19350	COG3608	succinylglutamate desuccinylase aspartoacylase
HW43_RS19350	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HW43_RS19355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW43_RS19360	COG2068	MobA-Related Protein
HW43_RS19365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS19365	COG0493	'glutamate synthase
HW43_RS19370	COG0402	S-adenosylhomocysteine deaminase activity
HW43_RS19375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HW43_RS19380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HW43_RS19380	COG2080	2 iron, 2 sulfur cluster binding
HW43_RS19385	COG2233	PERMEase
HW43_RS19390	COG0402	S-adenosylhomocysteine deaminase activity
HW43_RS19395	COG2252	PERMEase
HW43_RS19400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS19405	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS19405	COG0493	'glutamate synthase
HW43_RS19415	COG2233	PERMEase
HW43_RS19440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW43_RS19445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW43_RS19450	COG4974	Belongs to the 'phage' integrase family
HW43_RS19455	COG0716	FMN binding
HW43_RS19465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HW43_RS19475	COG1272	protein, Hemolysin III
HW43_RS19485	COG2723	6-phospho-beta-galactosidase activity
HW43_RS19490	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS19510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW43_RS19515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HW43_RS19520	COG0006	proline dipeptidase activity
HW43_RS19535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW43_RS19545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW43_RS19565	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW43_RS19565	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW43_RS19570	COG1703	isobutyryl-CoA mutase activity
HW43_RS19575	COG1024	Enoyl-CoA hydratase
HW43_RS19580	COG0427	acetyl-CoA hydrolase
HW43_RS19585	COG0583	DNA-binding transcription factor activity
HW43_RS19590	COG2968	Membrane
HW43_RS19595	COG1279	arginine transmembrane transporter activity
HW43_RS19600	COG0668	transmembrane transport
HW43_RS19610	COG0191	fructose-bisphosphate aldolase activity
HW43_RS19640	COG1122	ATPase activity
HW43_RS19645	COG1122	ATPase activity
HW43_RS19650	COG1072	(Pantothenic acid kinase))
HW43_RS19660	COG1494	fructose-1,6-bisphosphatase
HW43_RS19665	COG1063	alcohol dehydrogenase
HW43_RS19670	COG2213	PTS system mannitol-specific
HW43_RS19675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS19680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HW43_RS19685	COG0501	Belongs to the peptidase M48B family
HW43_RS19700	COG3716	PTS system mannose fructose sorbose family IID component
HW43_RS19705	COG3715	PTS system
HW43_RS19710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS19710	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS19735	COG1166	arginine decarboxylase activity
HW43_RS19760	COG2814	Major facilitator Superfamily
HW43_RS19770	COG2356	endonuclease I
HW43_RS19775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW43_RS19780	COG0189	ligase activity
HW43_RS19795	COG2805	Type II/IV secretion system protein
HW43_RS19800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW43_RS19805	COG0762	integral membrane protein
HW43_RS19820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW43_RS19830	COG0252	asparaginase activity
HW43_RS19845	COG3171	Protein conserved in bacteria
HW43_RS19855	COG1194	a g-specific adenine glycosylase
HW43_RS19870	COG2211	Major facilitator Superfamily
HW43_RS19875	COG1982	Orn Lys Arg decarboxylase major
HW43_RS19880	COG1811	Na channel or pump
HW43_RS19890	COG0582	viral genome integration into host DNA
HW43_RS19905	COG2194	sulfuric ester hydrolase activity
HW43_RS19915	COG3852	Histidine kinase
HW43_RS19920	COG2204	response regulator
HW43_RS19925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW43_RS19930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW43_RS19935	COG2031	fatty acid transporter
HW43_RS19940	COG0183	Belongs to the thiolase family
HW43_RS19945	COG4372	Transposase
HW43_RS19990	COG4771	TonB-dependent receptor
HW43_RS20020	COG3119	arylsulfatase activity
HW43_RS20045	COG2207	Transcriptional regulator
HW43_RS20070	COG4372	Transposase
HW43_RS20085	COG1475	DNA binding
HW43_RS20090	COG3969	phosphoadenosine phosphosulfate
HW43_RS20125	COG3210	domain, Protein
HW43_RS20235	COG4983	Phage plasmid primase, P4 family domain protein
HW43_RS20245	COG3468	outer membrane autotransporter barrel domain protein
HW43_RS20250	COG2020	methyltransferase activity
HW43_RS20275	COG2003	Belongs to the UPF0758 family
HW43_RS20315	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HW43_RS20345	COG2165	general secretion pathway protein
HW43_RS20350	COG1459	type II secretion system
HW43_RS20355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW43_RS20380	COG3064	Membrane
HW43_RS20395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HW43_RS20400	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HW43_RS20405	COG0247	lactate metabolic process
HW43_RS20410	COG0277	FAD linked oxidase domain protein
HW43_RS20415	COG0277	FAD linked oxidase domain protein
HW43_RS20420	COG2186	Transcriptional regulator
HW43_RS20425	COG0456	acetyltransferase
HW43_RS20430	COG0318	PFAM AMP-dependent synthetase and ligase
HW43_RS20440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW43_RS20445	COG0156	8-amino-7-oxononanoate synthase activity
HW43_RS20455	COG0795	lipopolysaccharide-transporting ATPase activity
HW43_RS20460	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HW43_RS20470	COG2244	polysaccharide biosynthetic process
HW43_RS20475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW43_RS20480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW43_RS20485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW43_RS20490	COG0306	phosphate transporter
HW43_RS20495	COG0754	glutathionylspermidine amidase activity
HW43_RS20500	COG0625	glutathione transferase activity
HW43_RS20505	COG0298	carbon dioxide binding
HW43_RS20515	COG1773	rubredoxin
HW43_RS20520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HW43_RS20525	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HW43_RS20530	COG5557	Pfam Polysulphide reductase, NrfD
HW43_RS20535	COG0437	4 iron, 4 sulfur cluster binding
HW43_RS20540	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HW43_RS20560	COG0667	Aldo Keto reductase
HW43_RS20570	COG1028	Short-chain dehydrogenase reductase Sdr
HW43_RS20575	COG0848	biopolymer transport protein
HW43_RS20580	COG0811	peptide transport
HW43_RS20590	COG0626	cystathionine gamma-synthase activity
HW43_RS20595	COG0586	Pfam SNARE associated Golgi protein
HW43_RS20600	COG2207	Transcriptional regulator
HW43_RS20610	COG1979	alcohol dehydrogenase
HW43_RS20615	COG0656	L-ascorbic acid biosynthetic process
HW43_RS20625	COG4238	major outer membrane lipoprotein
HW43_RS20630	COG1032	radical SAM domain protein
HW43_RS20635	COG2132	Multicopper oxidase
HW43_RS20640	COG0204	Acyl-transferase
HW43_RS20645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW43_RS20650	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HW43_RS20655	COG3111	PFAM Bacterial OB fold (BOF) protein
HW43_RS20660	COG0745	RESPONSE REGULATOR receiver
HW43_RS20665	COG0642	Histidine kinase
HW43_RS20675	COG2249	NAD(P)H dehydrogenase (quinone) activity
HW43_RS20680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HW43_RS20685	COG0187	DNA topoisomerase II activity
HW43_RS20690	COG3150	esterase
HW43_RS20695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HW43_RS20700	COG3151	Protein conserved in bacteria
HW43_RS20705	COG0494	nUDIX hydrolase
HW43_RS20710	COG1538	Outer membrane efflux protein
HW43_RS20725	COG0754	glutathionylspermidine amidase activity
HW43_RS20730	COG3384	dioxygenase
HW43_RS20750	COG2960	long-chain fatty acid transporting porin activity
HW43_RS20755	COG3539	Fimbrial protein
HW43_RS20760	COG3188	usher protein
HW43_RS20765	COG3121	Chaperone
HW43_RS20780	COG1585	Membrane protein implicated in regulation of membrane protease activity
HW43_RS20785	COG2268	Band 7 protein
HW43_RS20810	COG3025	triphosphatase activity
HW43_RS20820	COG4991	sh3 domain protein
HW43_RS20835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW43_RS20845	COG0583	DNA-binding transcription factor activity
HW43_RS20850	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HW43_RS20855	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HW43_RS20860	COG0471	metal ion transport
HW43_RS20870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HW43_RS20875	COG0358	DNA primase activity
HW43_RS20880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW43_RS20895	COG2375	cellular response to nickel ion
HW43_RS20900	COG1695	Transcriptional regulator
HW43_RS20905	COG0840	transmembrane signaling receptor activity
HW43_RS20915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW43_RS20920	COG1609	Transcriptional regulator
HW43_RS20925	COG3250	beta-galactosidase activity
HW43_RS20930	COG2731	YhcH YjgK YiaL family protein
HW43_RS20935	COG0531	amino acid
HW43_RS20945	COG3408	Glycogen debranching enzyme
HW43_RS20945	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HW43_RS20950	COG1902	pentaerythritol trinitrate reductase activity
HW43_RS20950	COG0446	pyridine nucleotide-disulphide oxidoreductase
HW43_RS20955	COG5499	transcription regulator containing HTH domain
HW43_RS20960	COG4680	protein conserved in bacteria
HW43_RS20970	COG1451	nucleotide metabolic process
HW43_RS20975	COG2949	membrane
HW43_RS20980	COG0673	inositol 2-dehydrogenase activity
HW43_RS20985	COG0861	Integral membrane protein TerC family
HW43_RS20990	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HW43_RS21000	COG2721	sulfolactate sulfo-lyase activity
HW43_RS21010	COG2271	Major facilitator Superfamily
HW43_RS21035	COG2186	Transcriptional regulator
HW43_RS21040	COG0586	Pfam SNARE associated Golgi protein
HW43_RS21050	COG1422	Protein of unknown function (DUF1090)
HW43_RS21055	COG4575	ribosome binding
HW43_RS21060	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HW43_RS21070	COG2259	Doxx family
HW43_RS21075	COG0435	Glutathione S-transferase
HW43_RS21080	COG3152	Membrane
HW43_RS21085	COG3152	Membrane
HW43_RS21090	COG0583	DNA-binding transcription factor activity
HW43_RS21095	COG1741	Belongs to the pirin family
HW43_RS21110	COG0814	amino acid
HW43_RS21115	COG1760	l-serine dehydratase
HW43_RS21120	COG0251	oxidation-reduction process
HW43_RS21125	COG1882	Formate acetyltransferase
HW43_RS21130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW43_RS21140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW43_RS21145	COG0583	DNA-binding transcription factor activity
HW43_RS21165	COG3547	Transposase (IS116 IS110 IS902 family)
HW43_RS21170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW43_RS21175	COG0826	peptidase U32
HW43_RS21180	COG0826	peptidase U32
HW43_RS21185	COG3154	lipid carrier protein
HW43_RS21190	COG3153	acetyltransferase
HW43_RS21210	COG0702	epimerase
HW43_RS21215	COG0701	Predicted permease
HW43_RS21220	COG2823	Periplasmic or secreted lipoprotein
HW43_RS21240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HW43_RS21245	COG3539	Fimbrial protein
HW43_RS21250	COG3188	usher protein
HW43_RS21255	COG3121	Chaperone
HW43_RS21260	COG3539	Fimbrial protein
HW43_RS21265	COG0363	glucosamine-6-phosphate deaminase activity
HW43_RS21270	COG3716	PTS system mannose fructose sorbose family IID component
HW43_RS21275	COG3715	PTS system
HW43_RS21280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS21290	COG2222	sugar isomerase
HW43_RS21295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW43_RS21300	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS21305	COG3716	PTS system mannose fructose sorbose family IID component
HW43_RS21315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW43_RS21325	COG1349	DNA-binding transcription factor activity
HW43_RS21335	COG2002	toxin-antitoxin pair type II binding
HW43_RS21340	COG2721	sulfolactate sulfo-lyase activity
HW43_RS21350	COG2271	Major facilitator Superfamily
HW43_RS21360	COG2084	Dehydrogenase
HW43_RS21365	COG1929	Belongs to the glycerate kinase type-1 family
HW43_RS21370	COG3547	Transposase (IS116 IS110 IS902 family)
HW43_RS21375	COG0814	amino acid
HW43_RS21385	COG0513	Belongs to the DEAD box helicase family
HW43_RS21420	COG0195	Participates in both transcription termination and antitermination
HW43_RS21440	COG2194	sulfuric ester hydrolase activity
HW43_RS21450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW43_RS21460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW43_RS21465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW43_RS21475	COG1534	Rna-binding protein
HW43_RS21480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW43_RS21485	COG2027	D-alanyl-D-alanine carboxypeptidase
HW43_RS21495	COG0697	spore germination
HW43_RS21510	COG0142	geranyltranstransferase activity
HW43_RS21515	COG3423	Transcriptional regulator
HW43_RS21525	COG5007	Belongs to the BolA IbaG family
HW43_RS21530	COG3113	response to antibiotic
HW43_RS21535	COG2854	intermembrane phospholipid transfer
HW43_RS21540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HW43_RS21545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HW43_RS21550	COG1127	ABC transporter
HW43_RS21555	COG0530	calcium, potassium:sodium antiporter activity
HW43_RS21560	COG0517	IMP dehydrogenase activity
HW43_RS21560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW43_RS21565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HW43_RS21570	COG3117	lipopolysaccharide transmembrane transporter activity
HW43_RS21575	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HW43_RS21580	COG1137	ATPase activity
HW43_RS21585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HW43_RS21590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HW43_RS21605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS21610	COG0515	serine threonine protein kinase
HW43_RS21620	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HW43_RS21625	COG5002	protein histidine kinase activity
HW43_RS21625	COG2198	Histidine kinase
HW43_RS21625	COG0784	Response regulator, receiver
HW43_RS21630	COG1242	4 iron, 4 sulfur cluster binding
HW43_RS21635	COG0069	glutamate synthase activity
HW43_RS21635	COG0067	glutamate synthase
HW43_RS21635	COG0070	glutamate synthase
HW43_RS21640	COG0493	'glutamate synthase
HW43_RS21645	COG4804	nuclease activity
HW43_RS21650	COG2731	YhcH YjgK YiaL family protein
HW43_RS21680	COG3069	C4-dicarboxylate transmembrane transporter activity
HW43_RS21685	COG2969	positive regulation of protein catabolic process
HW43_RS21690	COG0625	glutathione transferase activity
HW43_RS21705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HW43_RS21710	COG3105	Protein conserved in bacteria
HW43_RS21715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW43_RS21720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW43_RS21740	COG2732	(Barnase) inhibitor
HW43_RS21760	COG0583	DNA-binding transcription factor activity
HW43_RS21765	COG0312	modulator of DNA gyrase
HW43_RS21770	COG3164	Protein of unknown function
HW43_RS21775	COG1530	ribonuclease E activity
HW43_RS21785	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HW43_RS21790	COG1792	Involved in formation and maintenance of cell shape
HW43_RS21795	COG1077	Cell shape determining protein MreB Mrl
HW43_RS21805	COG2200	EAL domain
HW43_RS21805	COG2199	diguanylate cyclase activity
HW43_RS21810	COG0604	alcohol dehydrogenase
HW43_RS21830	COG0511	ligase activity, forming carbon-carbon bonds
HW43_RS21835	COG0439	Biotin carboxylase
HW43_RS21840	COG3924	membrane
HW43_RS21845	COG4145	pantothenate transmembrane transporter activity
HW43_RS21855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW43_RS21865	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HW43_RS21875	COG1309	transcriptional regulator
HW43_RS21880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW43_RS21885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW43_RS21905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW43_RS21910	COG4597	amino acid ABC transporter
HW43_RS21915	COG0765	amino acid transport
HW43_RS21920	COG1126	abc transporter atp-binding protein
HW43_RS21960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW43_RS21980	COG0551	DNA topoisomerase type I activity
HW43_RS21990	COG0758	DNA mediated transformation
HW43_RS22010	COG0569	domain protein
HW43_RS22020	COG3036	rescue of stalled ribosome
HW43_RS22025	COG0789	Transcriptional regulator
HW43_RS22065	COG0201	protein transport
HW43_RS22155	COG0089	rRNA binding
HW43_RS22230	COG2964	Protein conserved in bacteria
HW43_RS22235	COG0545	Peptidyl-prolyl cis-trans isomerase
HW43_RS22245	COG1047	Peptidyl-prolyl cis-trans
HW43_RS22250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HW43_RS22265	COG0488	(ABC) transporter
HW43_RS22270	COG0429	hydrolase of the alpha beta-hydrolase fold
HW43_RS22280	COG3954	Phosphoribulokinase
HW43_RS22285	COG1765	OsmC-like protein
HW43_RS22295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW43_RS22300	COG1289	transmembrane transporter activity
HW43_RS22305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW43_RS22310	COG0512	Glutamine amidotransferase of anthranilate synthase
HW43_RS22315	COG2184	nucleotidyltransferase activity
HW43_RS22325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW43_RS22335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW43_RS22340	COG2146	nitrite reductase [NAD(P)H] activity
HW43_RS22345	COG2116	formate transmembrane transporter activity
HW43_RS22360	COG0626	cystathionine gamma-synthase activity
HW43_RS22375	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HW43_RS22380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HW43_RS22385	COG3457	Alanine racemase
HW43_RS22395	COG2188	Transcriptional regulator
HW43_RS22400	COG0180	Tryptophanyl-tRNA synthetase
HW43_RS22410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW43_RS22415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HW43_RS22420	COG3266	domain, Protein
HW43_RS22435	COG4796	Type ii and iii secretion system protein
HW43_RS22450	COG3166	PFAM Fimbrial assembly family protein
HW43_RS22455	COG4972	Pilus assembly protein
HW43_RS22460	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HW43_RS22465	COG0494	nUDIX hydrolase
HW43_RS22475	COG1011	Hydrolase
HW43_RS22480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW43_RS22490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HW43_RS22515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW43_RS22520	COG2183	response to ionizing radiation
HW43_RS22525	COG1918	ferrous iron import across plasma membrane
HW43_RS22530	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW43_RS22540	COG5464	transposase or invertase
HW43_RS22560	COG2610	gluconate transmembrane transporter activity
HW43_RS22565	COG1640	4-alpha-glucanotransferase
HW43_RS22570	COG0058	SHG alpha-glucan phosphorylase activity
HW43_RS22585	COG1690	Belongs to the RtcB family
HW43_RS22590	COG4650	regulator
HW43_RS22595	COG1349	DNA-binding transcription factor activity
HW43_RS22610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW43_RS22630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW43_RS22635	COG0058	SHG alpha-glucan phosphorylase activity
HW43_RS22660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW43_RS22665	COG2095	MarC family integral membrane protein
HW43_RS22675	COG0514	ATP-dependent DNA helicase (RecQ)
HW43_RS22680	COG2610	gluconate transmembrane transporter activity
HW43_RS22685	COG3265	gluconokinase activity
HW43_RS22690	COG1609	Transcriptional regulator
HW43_RS22695	COG1741	Belongs to the pirin family
HW43_RS22700	COG0673	inositol 2-dehydrogenase activity
HW43_RS22705	COG1247	-acetyltransferase
HW43_RS22710	COG3157	Type VI secretion system effector, Hcp
HW43_RS22725	COG0405	Gamma-glutamyltransferase
HW43_RS22735	COG0584	glycerophosphoryl diester phosphodiesterase
HW43_RS22740	COG3842	ATPase activity
HW43_RS22745	COG0395	ABC-type sugar transport system, permease component
HW43_RS22750	COG1175	transmembrane transport
HW43_RS22755	COG1653	transport
HW43_RS22765	COG0410	ABC transporter
HW43_RS22770	COG0411	ABC transporter
HW43_RS22775	COG4177	L-phenylalanine transmembrane transporter activity
HW43_RS22780	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW43_RS22785	COG0683	leucine binding
HW43_RS22790	COG0456	acetyltransferase
HW43_RS22800	COG0683	leucine binding
HW43_RS22805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW43_RS22810	COG2177	Part of the ABC transporter FtsEX involved in
HW43_RS22815	COG2884	Cell division ATP-binding protein ftsE
HW43_RS22820	COG0552	protein localization to endoplasmic reticulum
HW43_RS22825	COG0742	ribosomal rna small subunit methyltransferase
HW43_RS22830	COG3776	membrane
HW43_RS22840	COG3714	YhhN family
HW43_RS22855	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HW43_RS22870	COG0628	permease
HW43_RS22875	COG2091	lysine biosynthetic process via aminoadipic acid
HW43_RS22880	COG0747	negative chemotaxis
HW43_RS22885	COG0601	transmembrane transport
HW43_RS22890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW43_RS22895	COG0444	Belongs to the ABC transporter superfamily
HW43_RS22920	COG0842	Transport permease protein
HW43_RS22925	COG0842	Transport permease protein
HW43_RS22925	COG1129	ABC transporter
HW43_RS22930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW43_RS22960	COG2081	HI0933 family
HW43_RS22965	COG0306	phosphate transporter
HW43_RS22975	COG0589	response to stress
HW43_RS22980	COG3104	oligopeptide transport
HW43_RS22990	COG0339	signal peptide processing
HW43_RS22995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HW43_RS23000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW43_RS23015	COG0640	Transcriptional regulator
HW43_RS23020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW43_RS23025	COG1393	Belongs to the ArsC family
HW43_RS23045	COG3065	identical protein binding
HW43_RS23050	COG2197	response regulator
HW43_RS23055	COG1285	pathogenesis
HW43_RS23070	COG3247	response to pH
HW43_RS23075	COG2771	luxR family
HW43_RS23085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW43_RS23090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW43_RS23095	COG2207	Transcriptional regulator
HW43_RS23105	COG0076	glutamate decarboxylase activity
HW43_RS23110	COG1858	cytochrome C peroxidase
HW43_RS23120	COG2197	response regulator
HW43_RS23125	COG0583	DNA-binding transcription factor activity
HW43_RS23130	COG1295	ribonuclease BN
HW43_RS23135	COG0477	Major facilitator Superfamily
HW43_RS23140	COG2982	Protein involved in outer membrane biogenesis
HW43_RS23145	COG2200	EAL domain
HW43_RS23160	COG0612	Peptidase, M16
HW43_RS23170	COG2199	diguanylate cyclase activity
HW43_RS23170	COG2200	EAL domain
HW43_RS23175	COG0457	Tetratricopeptide repeat
HW43_RS23175	COG3118	belongs to the thioredoxin family
HW43_RS23180	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HW43_RS23185	COG1215	transferase activity, transferring glycosyl groups
HW43_RS23190	COG1215	transferase activity, transferring glycosyl groups
HW43_RS23215	COG2194	sulfuric ester hydrolase activity
HW43_RS23240	COG0814	amino acid
HW43_RS23245	COG4608	Belongs to the ABC transporter superfamily
HW43_RS23250	COG0444	Belongs to the ABC transporter superfamily
HW43_RS23255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW43_RS23260	COG0601	transmembrane transport
HW43_RS23270	COG0747	negative chemotaxis
HW43_RS23280	COG2194	sulfuric ester hydrolase activity
HW43_RS23310	COG2223	nitrite transmembrane transporter activity
HW43_RS23315	COG5571	outer membrane autotransporter
HW43_RS23320	COG2818	Glycosylase
HW43_RS23325	COG0456	acetyltransferase
HW43_RS23330	COG0243	molybdopterin cofactor binding
HW43_RS23335	COG2885	chlorophyll binding
HW43_RS23350	COG2944	sequence-specific DNA binding
HW43_RS23355	COG1278	Cold shock
HW43_RS23380	COG3274	enterobacterial common antigen metabolic process
HW43_RS23385	COG4682	membrane
HW43_RS23390	COG4682	membrane
HW43_RS23395	COG1070	Carbohydrate kinase
HW43_RS23405	COG4213	ABC transporter substrate-binding protein
HW43_RS23410	COG1129	ABC transporter
HW43_RS23415	COG4214	carbohydrate transport
HW43_RS23420	COG2207	Transcriptional regulator
HW43_RS23420	COG1609	Transcriptional regulator
HW43_RS23425	COG2992	FlgJ-related protein
HW43_RS23430	COG0366	Alpha amylase catalytic
HW43_RS23435	COG3977	Valine--pyruvate aminotransferase
HW43_RS23445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HW43_RS23450	COG1414	Transcriptional regulator
HW43_RS23460	COG2731	YhcH YjgK YiaL family protein
HW43_RS23465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HW43_RS23470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HW43_RS23475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HW43_RS23480	COG1070	Carbohydrate kinase
HW43_RS23485	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HW43_RS23490	COG3623	hexulose-6-phosphate isomerase
HW43_RS23495	COG0235	Class ii aldolase
HW43_RS23500	COG3713	MltA-interacting MipA family protein
HW43_RS23505	COG0583	DNA-binding transcription factor activity
HW43_RS23510	COG1566	PFAM secretion protein HlyD family protein
HW43_RS23525	COG1012	belongs to the aldehyde dehydrogenase family
HW43_RS23530	COG1454	alcohol dehydrogenase
HW43_RS23535	COG3276	selenocysteine insertion sequence binding
HW43_RS23545	COG0625	glutathione transferase activity
HW43_RS23550	COG3209	COG3209 Rhs family protein
HW43_RS23560	COG1413	lyase activity
HW43_RS23565	COG3209	COG3209 Rhs family protein
HW43_RS23570	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HW43_RS23580	COG1566	PFAM secretion protein HlyD family protein
HW43_RS23590	COG2213	PTS system mannitol-specific
HW43_RS23590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW43_RS23600	COG3722	fumarate hydratase activity
HW43_RS23620	COG5295	Hep Hag repeat protein
HW43_RS23625	COG1620	l-lactate permease
HW43_RS23630	COG2186	Transcriptional regulator
HW43_RS23640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW43_RS23645	COG1045	serine acetyltransferase
HW43_RS23660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HW43_RS23665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW43_RS23675	COG4942	peptidase
HW43_RS23680	COG2861	carbohydrate metabolic process
HW43_RS23685	COG1216	Glycosyl transferase, family 2
HW43_RS23695	COG0156	8-amino-7-oxononanoate synthase activity
HW43_RS23710	COG0859	PFAM glycosyl transferase family 9
HW43_RS23715	COG0859	PFAM glycosyl transferase family 9
HW43_RS23735	COG3642	lipopolysaccharide core region biosynthetic process
HW43_RS23745	COG0515	serine threonine protein kinase
HW43_RS23750	COG0438	transferase activity, transferring glycosyl groups
HW43_RS23755	COG0859	PFAM glycosyl transferase family 9
HW43_RS23760	COG1519	Transferase
HW43_RS23790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW43_RS23815	COG1561	YicC-like family, N-terminal region
HW43_RS23820	COG3645	SOS response
HW43_RS23825	COG2860	membrane
HW43_RS23835	COG0194	GDP metabolic process
HW43_RS23845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW43_RS23850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW43_RS23855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW43_RS23860	COG0786	glutamate:sodium symporter activity
HW43_RS23865	COG2233	PERMEase
HW43_RS23870	COG2982	Protein involved in outer membrane biogenesis
HW43_RS23875	COG1501	Belongs to the glycosyl hydrolase 31 family
HW43_RS23880	COG2211	Major facilitator Superfamily
HW43_RS23895	COG2814	Major facilitator Superfamily
HW43_RS23900	COG0697	spore germination
HW43_RS23905	COG1464	Belongs to the NlpA lipoprotein family
HW43_RS23930	COG2252	PERMEase
HW43_RS23940	COG2271	Major facilitator Superfamily
HW43_RS23945	COG2271	Major facilitator Superfamily
HW43_RS23950	COG3851	Histidine kinase
HW43_RS23955	COG2197	response regulator
HW43_RS23960	COG0440	acetolactate synthase activity
HW43_RS23965	COG0028	Belongs to the TPP enzyme family
HW43_RS23985	COG2814	Major facilitator Superfamily
HW43_RS23990	COG0641	radical SAM
HW43_RS24000	COG2149	membrane
HW43_RS24010	COG3119	arylsulfatase activity
HW43_RS24015	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW43_RS24020	COG2207	Transcriptional regulator
HW43_RS24035	COG2188	Transcriptional regulator
HW43_RS24040	COG2188	Transcriptional regulator
HW43_RS24060	COG5645	(Lipo)protein
HW43_RS24065	COG0823	Involved in the tonB-independent uptake of proteins
HW43_RS24075	COG2271	Major facilitator Superfamily
HW43_RS24085	COG0800	Aldolase
HW43_RS24090	COG3734	2-keto-3-deoxy-galactonokinase
HW43_RS24095	COG2186	Transcriptional regulator
HW43_RS24105	COG0561	phosphatase activity
HW43_RS24110	COG3753	Protein conserved in bacteria
HW43_RS24120	COG0187	DNA topoisomerase II activity
HW43_RS24130	COG0592	DNA-directed DNA polymerase activity
HW43_RS24315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW43_RS24985	COG4932	domain protein
HW43_RS24985	COG2373	Large extracellular alpha-helical protein
HW43_RS24985	COG1388	LysM domain
HW43_RS24990	COG1388	LysM domain
HW43_RS24990	COG4932	domain protein
HW43_RS24990	COG2373	Large extracellular alpha-helical protein
HW43_RS24995	COG5301	cellulose 1,4-beta-cellobiosidase activity