locus-tag class description HVW38_RS00010 ENOG4105VZ1 Replication Protein HVW38_RS00020 ENOG4105F5W AtP-binding protein HVW38_RS00025 ENOG4105D70 Integrase catalytic subunit HVW38_RS00120 ENOG4108X9F tail fiber protein HVW38_RS00125 ENOG4105UZW Tail fiber assembly protein HVW38_RS00170 ENOG4105ZTC transcriptional activator, Ogr delta HVW38_RS00185 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVW38_RS00200 ENOG4105EBK exported protein HVW38_RS00205 ENOG4108VTS Membrane HVW38_RS00210 ENOG41065TG regulatoR HVW38_RS00220 ENOG4105DP0 ferredoxin-NADP reductase HVW38_RS00225 ENOG4105CBT Fructose-1,6-bisphosphatase HVW38_RS00235 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVW38_RS00250 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVW38_RS00265 ENOG41063M6 Cell Division Protein HVW38_RS00270 ENOG4105ETE Transcriptional regulator (LacI family HVW38_RS00275 ENOG4105C25 Primosomal protein n' HVW38_RS00290 ENOG4107S01 Repressor protein MetJ HVW38_RS00300 ENOG4105C28 cystathionine HVW38_RS00305 ENOG4105CFH Aspartokinase HVW38_RS00315 ENOG4105CGH 5'-nucleotidase HVW38_RS00325 ENOG4105CN8 Transcriptional regulator HVW38_RS00330 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HVW38_RS00335 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVW38_RS00355 ENOG4105SYT Methylenetetrahydrofolate reductase HVW38_RS00365 ENOG4108Q5Y Membrane HVW38_RS00370 ENOG4108XC3 NADH ubiquinone oxidoreductase HVW38_RS00375 ENOG4105DCT glycerol dehydrogenase HVW38_RS00380 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVW38_RS00385 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVW38_RS00390 ENOG4105DM4 PTS System HVW38_RS00395 ENOG4108YRF PTS System HVW38_RS00405 ENOG4108AHH pyruvate formate lyase II activase HVW38_RS00410 ENOG4108XCZ PTS System HVW38_RS00415 ENOG4106R3P AraC family transcriptional regulator HVW38_RS00420 ENOG4105DIJ Phosphoethanolamine transferase HVW38_RS00435 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVW38_RS00450 ENOG4105C5Q Transcriptional regulator HVW38_RS00460 ENOG4105CH2 amidohydrolase HVW38_RS00470 ENOG4105EJ2 Transcriptional regulator HVW38_RS00475 ENOG4108Y73 Membrane HVW38_RS00515 ENOG4105D4A Cell wall formation (By similarity) HVW38_RS00520 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVW38_RS00555 ENOG4105PM1 preprotein translocase subunit SecE HVW38_RS00560 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVW38_RS00595 ENOG4105D41 biosynthesis protein thiH HVW38_RS00605 ENOG4105WHD thiamine biosynthesis protein ThiS HVW38_RS00610 ENOG4105D06 uba thif-type nad fad binding protein HVW38_RS00645 ENOG4105R2J Conserved Protein HVW38_RS00660 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVW38_RS00665 ENOG4105BZU Histidine kinase HVW38_RS00670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVW38_RS00675 ENOG4105C12 Phosphoribosylglycinamide synthetase HVW38_RS00705 ENOG4105K5X acetyltransferase HVW38_RS00715 ENOG4107QP3 malate synthase g HVW38_RS00720 ENOG4108I9X Isocitrate lyase HVW38_RS00735 ENOG41069M3 Transcriptional regulator HVW38_RS00740 ENOG4105C3R Methionine synthase HVW38_RS00755 ENOG4105EAM Na Pi-cotransporter HVW38_RS00760 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVW38_RS00765 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVW38_RS00770 ENOG4105F3R pts system mannose fructose sorbose family iid HVW38_RS00775 ENOG4105ETZ PTS System HVW38_RS00785 ENOG4105KPI PTS system sorbose subfamily IIB component HVW38_RS00790 ENOG4108XCU pts system HVW38_RS00795 ENOG4105CHR reductase HVW38_RS00800 ENOG4105DKT Transcriptional regulator HVW38_RS00805 ENOG4105FE9 pseudouridine synthase HVW38_RS00810 ENOG4108ZR5 Conserved Protein HVW38_RS00850 ENOG410685N tail fiber protein HVW38_RS00930 ENOG4107SC1 transglycosylase HVW38_RS00945 ENOG4108WZA zeta toxin HVW38_RS00950 ENOG4105CFH Aspartokinase HVW38_RS00955 ENOG4107QP8 phosphohexose isomerase HVW38_RS00965 ENOG4108MDC (LipO)protein HVW38_RS00970 ENOG4108Q9C Periplasmic Protein HVW38_RS00975 ENOG4105E3R (LipO)protein HVW38_RS00990 ENOG4107QNK )-transporter HVW38_RS00995 ENOG4105EG2 ABC transporter, permease HVW38_RS01000 ENOG4105D56 permease protein HVW38_RS01005 ENOG4107FKK extracellular solute-binding protein family 1 HVW38_RS01010 ENOG4108IJ9 (ABC) transporter HVW38_RS01020 ENOG4107W52 maltose operon periplasmic protein HVW38_RS01035 ENOG4108RS6 transposase HVW38_RS01045 ENOG41080IJ Diacylglycerol kinase HVW38_RS01055 ENOG4107R73 Mate efflux family protein HVW38_RS01060 ENOG4105VDW Csbd family HVW38_RS01065 ENOG4105MYN Zinc uptake regulation protein HVW38_RS01070 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVW38_RS01075 ENOG4105P4Z Phage shock protein G HVW38_RS01080 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVW38_RS01085 ENOG4105CDU Replicative dna helicase HVW38_RS01095 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVW38_RS01100 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVW38_RS01105 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVW38_RS01110 ENOG4105CGF Aromatic amino acid aminotransferase HVW38_RS01115 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVW38_RS01120 ENOG4105C7S Dehydrogenase HVW38_RS01125 ENOG4107QN2 dihydrolipoyl dehydrogenase HVW38_RS01130 ENOG4105CMV Succinyl-CoA synthetase subunit beta HVW38_RS01135 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVW38_RS01140 ENOG4107QPK )-transporter HVW38_RS01145 ENOG4105DG4 malate L-lactate dehydrogenase HVW38_RS01150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVW38_RS01155 ENOG4105CQZ Histidine kinase HVW38_RS01160 ENOG4105F0S class B acid phosphatase HVW38_RS01165 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVW38_RS01170 ENOG4105MSB protein, conserved in bacteria HVW38_RS01175 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVW38_RS01180 ENOG4108UUM single-stranded DNA-binding protein HVW38_RS01185 ENOG4105PMV Membrane HVW38_RS01190 ENOG4108W3Q Transcriptional regulator HVW38_RS01195 ENOG4108Z4X TRANSCRIPTIONal HVW38_RS01200 ENOG4105C7N Xanthine uracil vitamin C permease HVW38_RS01205 ENOG4105EEQ Na H antiporter HVW38_RS01210 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVW38_RS01215 ENOG4108F5E vimentin HVW38_RS01220 ENOG4108YIV HVW38_RS01225 ENOG4105CSH Transporter HVW38_RS01230 ENOG4105ECM Sensor protein basS pmrB HVW38_RS01235 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVW38_RS01240 ENOG4105DIJ Phosphoethanolamine transferase HVW38_RS01245 ENOG4106ZGR Transcriptional regulator HVW38_RS01250 ENOG4108R5S membrane HVW38_RS01255 ENOG4107GFK fumarate HVW38_RS01260 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVW38_RS01265 ENOG4108MRH transcriptional regulatory protein HVW38_RS01270 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVW38_RS01275 ENOG4107QY8 reductase HVW38_RS01280 ENOG4105QAX Iron-sulfur HVW38_RS01285 ENOG4107KGK dmso reductase anchor subunit HVW38_RS01290 ENOG4108NEM leader-binding protein dmsD HVW38_RS01310 ENOG4108SIC Transcriptional regulator HVW38_RS01315 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVW38_RS01325 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVW38_RS01330 ENOG4108IJ0 Aspartate ammonia-lyase HVW38_RS01335 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVW38_RS01340 ENOG4105DVH amino acid HVW38_RS01355 ENOG4108ZVF (LipO)protein HVW38_RS01360 ENOG4105MTB Uncharacterized protein YjeJ HVW38_RS01365 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVW38_RS01375 ENOG4107PEH Entericidin EcnA/B family HVW38_RS01380 ENOG4106BSU Entericidin B HVW38_RS01385 ENOG4105KPY Small multidrug resistance protein HVW38_RS01390 ENOG4105QNF Outer membrane lipoprotein HVW38_RS01395 ENOG41066YJ Beta-lactamase HVW38_RS01410 ENOG4105E33 succinate dehydrogenase HVW38_RS01415 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVW38_RS01425 ENOG4107SC7 Inner membrane transporter yjeM HVW38_RS01430 ENOG4106CG8 Inner membrane protein YjeO HVW38_RS01435 ENOG4105EGS Mechanosensitive ion channel HVW38_RS01455 ENOG4106TNF Periplasmic binding protein HVW38_RS01480 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVW38_RS01485 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVW38_RS01490 ENOG4105K8N protein family UPF0079, ATPase HVW38_RS01495 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVW38_RS01515 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVW38_RS01520 ENOG4107QJR hflk protein HVW38_RS01525 ENOG4105EPW hflc protein HVW38_RS01545 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVW38_RS01550 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVW38_RS01555 ENOG4105FUX Conserved Protein HVW38_RS01560 ENOG4108P9J Phage shock protein A HVW38_RS01565 ENOG4107VNS Protein of unknown function (DUF2491) HVW38_RS01570 ENOG4105Z6B inner membrane protein yjfl HVW38_RS01575 ENOG4108KXT Conserved Protein HVW38_RS01580 ENOG4106032 Glutathionylspermidine synthase HVW38_RS01585 ENOG4105CSU acyl-Coa dehydrogenase HVW38_RS01590 ENOG4105S17 UPF0379 protein yjfN HVW38_RS01595 ENOG4105WSB biofilm stress and motility protein A HVW38_RS01600 ENOG4108MXZ Esterase HVW38_RS01605 ENOG4105DW5 Transcriptional regulator HVW38_RS01615 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVW38_RS01620 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVW38_RS01645 ENOG4105KIT UPF0379 protein yjfY HVW38_RS01660 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVW38_RS01670 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVW38_RS01690 ENOG4105CHR reductase HVW38_RS01700 ENOG4105FHY Opacity-associated protein A HVW38_RS01705 ENOG4108V1T peptidylprolyl cis-trans isomerase HVW38_RS01720 ENOG4105DXC membrane HVW38_RS01725 ENOG4105ECR NmrA family HVW38_RS01730 ENOG4105KVH Transcriptional regulator HVW38_RS01735 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVW38_RS01740 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVW38_RS01745 ENOG4108UUE Transcriptional regulator HVW38_RS01750 ENOG41061GZ Protein of unknown function (DUF1107) HVW38_RS01755 ENOG4105C37 (CBS) domain HVW38_RS01760 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVW38_RS01770 ENOG4108YZG isomerase HVW38_RS01775 ENOG4105NYY transcriptional regulator, RpiR HVW38_RS01780 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVW38_RS01785 ENOG4105C2J ABC transporter HVW38_RS01790 ENOG4105CNN ABC, transporter HVW38_RS01795 ENOG4105UP7 3-epimerase HVW38_RS01800 ENOG4107TFG D-allose kinase HVW38_RS01805 ENOG4105EUZ Beta-lactamase domain protein HVW38_RS01815 ENOG4105J12 Multidrug resistance protein mdtN HVW38_RS01820 ENOG4108MI0 Resistance protein HVW38_RS01825 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVW38_RS01835 ENOG41082ND Uncharacterized protein yjcO HVW38_RS01840 ENOG4105CK2 sodium dicarboxylate symporter HVW38_RS01845 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVW38_RS01850 ENOG41062QD Membrane HVW38_RS01865 ENOG4105CFU surface antigen HVW38_RS01870 ENOG4105MA0 exported protein HVW38_RS01875 ENOG4108ZHD aig2 family HVW38_RS01880 ENOG4105F0N pyrophosphate phospho-hydrolase HVW38_RS01885 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVW38_RS01890 ENOG4105C2J ABC transporter HVW38_RS01895 ENOG4107R9N ABC transporter HVW38_RS01900 ENOG41062B0 ABC transporter, permease HVW38_RS01910 ENOG4105DFU Cell wall formation (By similarity) HVW38_RS01920 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVW38_RS01925 ENOG4108XVM Cytochrome b(562) HVW38_RS01940 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVW38_RS01945 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVW38_RS01950 ENOG4105CG3 alpha amylase, catalytic region HVW38_RS01955 ENOG4105C5Y PTS System HVW38_RS01960 ENOG4105D4X repressor HVW38_RS01970 ENOG4105KME endoribonuclease L-psp HVW38_RS01985 ENOG4107C93 pyrBI operon leader peptide HVW38_RS01995 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVW38_RS02000 ENOG4105DBV ornithine carbamoyltransferase HVW38_RS02015 ENOG4105XEP YhcH YjgK YiaL family protein HVW38_RS02020 ENOG4105DBV ornithine carbamoyltransferase HVW38_RS02025 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVW38_RS02030 ENOG4108MJ3 acetyltransferase HVW38_RS02035 ENOG4108M3P Membrane HVW38_RS02040 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVW38_RS02045 ENOG4105MYG DNA polymerase iii, chi subunit HVW38_RS02055 ENOG4108M8S permease YjgP YjgQ family protein HVW38_RS02060 ENOG4108K5H permease YjgP YjgQ family protein HVW38_RS02065 ENOG4105W4M Transport-associated protein HVW38_RS02085 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVW38_RS02095 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HVW38_RS02100 ENOG4105DT3 PTS system, galactitol-specific IIc component HVW38_RS02105 ENOG41090UW PTS System HVW38_RS02110 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HVW38_RS02120 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVW38_RS02125 ENOG4105DM4 PTS System HVW38_RS02130 ENOG4106VEM tagatose-6-phosphate kinase HVW38_RS02135 ENOG4105D2N Aldolase HVW38_RS02140 ENOG4105MVE transcriptional regulator HVW38_RS02145 ENOG4107UEK pfkb domain protein HVW38_RS02150 ENOG4105CTX dehydratase HVW38_RS02160 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVW38_RS02170 ENOG4108CNN domain protein HVW38_RS02175 ENOG4105CWB LysR family transcriptional Regulator HVW38_RS02180 ENOG4105KAF membrAne HVW38_RS02185 ENOG4105CHF Glutathione S-transferase HVW38_RS02190 ENOG4108VBZ doxx family HVW38_RS02195 ENOG4105YJD HVW38_RS02200 ENOG41090KG Inner membrane protein YqjE HVW38_RS02205 ENOG4105NE1 Conserved Protein HVW38_RS02210 ENOG4105WAY exported protein HVW38_RS02220 ENOG4106W5V Membrane HVW38_RS02225 ENOG4107YCY Transcriptional regulator HVW38_RS02230 ENOG4105DPW Major facilitator superfamily MFS_1 HVW38_RS02240 ENOG4105CTX dehydratase HVW38_RS02245 ENOG4105P66 Membrane HVW38_RS02250 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVW38_RS02255 ENOG4105DU1 integral membrane protein, terc HVW38_RS02260 ENOG4105EE0 oxidoreductase HVW38_RS02265 ENOG4108UB4 uncharacterized protein ygjQ HVW38_RS02270 ENOG4108VKG metal-dependent hydrolase HVW38_RS02290 ENOG4105RI1 glycoprotein receptor HVW38_RS02295 ENOG4106CVF DNA replication protein HVW38_RS02300 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HVW38_RS02305 ENOG4107XM3 UPF0442 protein HVW38_RS02310 ENOG4105DWK Membrane HVW38_RS02315 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HVW38_RS02320 ENOG4105EZV Transcriptional regulator HVW38_RS02325 ENOG4108N8T regulatoR HVW38_RS02330 ENOG4108T94 DNA-binding transcriptional activator BglJ HVW38_RS02335 ENOG4108819 ferric iron reductase HVW38_RS02340 ENOG4105YBH Protein of unknown function (DUF1435) HVW38_RS02365 ENOG4108WPU DNA polymerase III subunit psi HVW38_RS02370 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVW38_RS02375 ENOG4105PAD Hydrolase HVW38_RS02395 ENOG4108R7K Metal Dependent Phosphohydrolase HVW38_RS02400 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HVW38_RS02405 ENOG4105H40 HVW38_RS02435 ENOG4108S1U HVW38_RS02455 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVW38_RS02465 ENOG4108MXB Protein of unknown function (DUF968) HVW38_RS02470 ENOG4105HGD Antitermination protein HVW38_RS02485 ENOG4105VEQ Cold shock protein HVW38_RS02490 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVW38_RS02510 ENOG4108YV9 Protein of unknown function (DUF2514) HVW38_RS02515 ENOG4105VEQ Cold shock protein HVW38_RS02525 ENOG4106IAW HVW38_RS02530 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVW38_RS02560 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HVW38_RS02630 ENOG4108X9F tail fiber protein HVW38_RS02640 ENOG4105MN3 Resolvase HVW38_RS02645 ENOG4105W3V DNA-binding, transcriptional regulator HVW38_RS02655 ENOG4106FE3 DNA repair HVW38_RS02665 ENOG4105K3G Periplasmic Protein HVW38_RS02675 ENOG4108NRW Phospholipase, patatin family HVW38_RS02680 ENOG4105EYA deoxyribonuclease HVW38_RS02685 ENOG41076CZ activating enzyme HVW38_RS02690 ENOG4105G0K glycine radical enzyme YjjI family HVW38_RS02725 ENOG41062Z9 Membrane HVW38_RS02730 ENOG4105EAC phosphoserine phosphatase HVW38_RS02735 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVW38_RS02740 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVW38_RS02745 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HVW38_RS02755 ENOG4105C5H ABC transporter HVW38_RS02760 ENOG4107SC1 transglycosylase HVW38_RS02780 ENOG4105UEI Transcriptional Regulator AraC Family HVW38_RS02785 ENOG4108RH0 Crea protein HVW38_RS02790 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVW38_RS02795 ENOG4105EB3 Histidine kinase HVW38_RS02800 ENOG4105CT7 inner membrane cred family protein HVW38_RS02805 ENOG41065U4 response regulator HVW38_RS02810 ENOG410759A HVW38_RS02815 ENOG4106FVC RNA methyltransferase HVW38_RS02825 ENOG4105CFH Aspartokinase HVW38_RS02835 ENOG4105D98 threonine synthase HVW38_RS02840 ENOG41062C6 Protein of unknown function (DUF2502) HVW38_RS02850 ENOG4105BZG amino acid carrier protein HVW38_RS02860 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVW38_RS02865 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVW38_RS02880 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVW38_RS02890 ENOG41063Z6 transcriptional regulator, lysR family HVW38_RS02900 ENOG410647N response to DNA damage stimulus HVW38_RS02905 ENOG4105DTN riboflavin biosynthesis protein ribF HVW38_RS02920 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVW38_RS02940 ENOG4106YYS transcriptional regulatory protein HVW38_RS02945 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVW38_RS02950 ENOG4105D9Q decarboxylase (Beta subunit) HVW38_RS02955 ENOG4107QSA Oxaloacetate decarboxylase HVW38_RS02965 ENOG4105D2K citrate carrier protein HVW38_RS02970 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVW38_RS02980 ENOG4105CI0 Citrate lyase HVW38_RS02985 ENOG4105CHY citrate lyase, alpha HVW38_RS03010 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVW38_RS03015 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVW38_RS03020 ENOG4108XNW Transcriptional activatory protein CaiF HVW38_RS03030 ENOG4106YT9 Enoyl-CoA hydratase HVW38_RS03065 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVW38_RS03070 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVW38_RS03075 ENOG4105C54 Major Facilitator superfamily HVW38_RS03090 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVW38_RS03130 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVW38_RS03140 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVW38_RS03145 ENOG4105D3G Pseudouridine synthase HVW38_RS03155 ENOG4105CQ2 DNA polymerase HVW38_RS03160 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVW38_RS03180 ENOG4108RVA ribokinase HVW38_RS03205 ENOG4108KF1 Membrane HVW38_RS03215 ENOG4106SMU thiamine transporter membrane protein HVW38_RS03220 ENOG4105DP9 ABC transporter HVW38_RS03225 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HVW38_RS03250 ENOG4105DJB Major Facilitator Superfamily HVW38_RS03255 ENOG4105DND Transcriptional regulator HVW38_RS03260 ENOG4105FF2 Type I DHQase HVW38_RS03265 ENOG4105EMV Major Facilitator HVW38_RS03280 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HVW38_RS03305 ENOG41064T2 transcriptional regulator, lysR family HVW38_RS03310 ENOG4105C7K acetolactate synthase HVW38_RS03315 ENOG4108ZP8 Acetolactate synthase small subunit HVW38_RS03325 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVW38_RS03340 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVW38_RS03345 ENOG4105CJN penicillin-binding protein HVW38_RS03350 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVW38_RS03355 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVW38_RS03365 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVW38_RS03370 ENOG4105CNI cell division protein FtsW HVW38_RS03385 ENOG4105CPF Cell wall formation (By similarity) HVW38_RS03390 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVW38_RS03395 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVW38_RS03400 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVW38_RS03420 ENOG4105M6F mutator MutT protein HVW38_RS03435 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVW38_RS03445 ENOG4105D7Q type ii secretion system HVW38_RS03450 ENOG4107QHF type ii secretion system protein e HVW38_RS03470 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVW38_RS03480 ENOG4106A72 regulatory protein AmpE HVW38_RS03485 ENOG4105C85 amino acid HVW38_RS03490 ENOG41073TP transcriptional regulator HVW38_RS03495 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVW38_RS03500 ENOG4107QSN dihydrolipoamide acetyltransferase HVW38_RS03505 ENOG4107QN2 dihydrolipoyl dehydrogenase HVW38_RS03510 ENOG4108NST exported protein HVW38_RS03515 ENOG4107QIJ Aconitate hydratase 2 HVW38_RS03535 ENOG4108ZRK uncharacterized protein yacC HVW38_RS03540 ENOG4105E3B Multicopper oxidase HVW38_RS03550 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVW38_RS03555 ENOG41077A9 carbonic anhydrase HVW38_RS03560 ENOG4105DA5 (ABC) transporter HVW38_RS03565 ENOG4105E3A (ABC) transporter HVW38_RS03570 ENOG4108YTN IIa component HVW38_RS03575 ENOG4107BJW polysaccharide deacetylase HVW38_RS03585 ENOG4108A32 Transposase HVW38_RS03610 ENOG4105SYG Fimbrial protein HVW38_RS03615 ENOG4108XEY fimbrial-like adhesin protein HVW38_RS03620 ENOG4105CW0 outer membrane usher protein HVW38_RS03625 ENOG4108VEV chaperone HVW38_RS03635 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVW38_RS03640 ENOG4105DJ0 Poly(A) Polymerase HVW38_RS03660 ENOG4107XID 2'-5' rna ligase HVW38_RS03665 ENOG4105CQ7 ATP-dependent helicase HVW38_RS03670 ENOG4105BZ4 penicillin-binding protein HVW38_RS03675 ENOG4105E0K tonB-dependent siderophore receptor HVW38_RS03680 ENOG4105E0A ABC, transporter HVW38_RS03685 ENOG4105J76 Periplasmic binding protein HVW38_RS03690 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVW38_RS03715 ENOG4105EN6 Membrane HVW38_RS03720 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVW38_RS03735 ENOG4105C0H protease HVW38_RS03740 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVW38_RS03750 ENOG4105DIN metallophosphoesterase HVW38_RS03765 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVW38_RS03790 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVW38_RS03795 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVW38_RS03800 ENOG4105KNE Phosphatidate cytidylyltransferase HVW38_RS03805 ENOG4105DZP Membrane-associated zinc metalloprotease HVW38_RS03815 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVW38_RS03820 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVW38_RS03840 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HVW38_RS03845 ENOG4105C0B DNA polymerase III (alpha subunit) HVW38_RS03850 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HVW38_RS03855 ENOG4105CXN decarboxylase HVW38_RS03860 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVW38_RS03865 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVW38_RS03870 ENOG4105M1T rho-binding antiterminator HVW38_RS03880 ENOG4108VWS Yaeq family HVW38_RS03885 ENOG4108YZN class I peptide chain release factor HVW38_RS03890 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVW38_RS03895 ENOG4108UY0 (LipO)protein HVW38_RS03905 ENOG4108R96 Methyltransferase, YaeB family HVW38_RS03910 ENOG4108R8X outer membrane lipoprotein HVW38_RS03915 ENOG4105D01 (LipO)protein HVW38_RS03920 ENOG4108UMI ABC transporter, permease HVW38_RS03925 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVW38_RS03930 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVW38_RS03970 ENOG4105HEI LysR family (Transcriptional regulator HVW38_RS03980 ENOG4105F2W methyltransferase HVW38_RS03985 ENOG4105E9H Lytic Murein transglycosylase HVW38_RS03995 ENOG4105D1A Methyltransferase HVW38_RS04005 ENOG4107RZZ dna polymerase iii epsilon subunit HVW38_RS04015 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVW38_RS04020 ENOG4108WN0 inhibitor of vertebrate lysozyme HVW38_RS04025 ENOG4107QPN acyl-Coa dehydrogenase HVW38_RS04035 ENOG4105E7A Glutamine amidotransferase HVW38_RS04040 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVW38_RS04045 ENOG4108YS0 lipoprotein YafL HVW38_RS04055 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVW38_RS04075 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVW38_RS04080 ENOG4105CUZ uba thif-type nad fad binding protein HVW38_RS04085 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVW38_RS04090 ENOG4105C9B Cysteine desulfurase HVW38_RS04095 ENOG4105M5B (LipO)protein HVW38_RS04100 ENOG4105ETT transcriptional Regulator, LysR family HVW38_RS04105 ENOG4105M08 Membrane HVW38_RS04120 ENOG4105EJQ L-serine dehydratase HVW38_RS04125 ENOG4105C44 Serine transporter HVW38_RS04130 ENOG4105EWT decarboxylase family HVW38_RS04145 ENOG4105WP7 tRNA pseudouridine synthase C HVW38_RS04150 ENOG4105DR9 pseudouridine synthase HVW38_RS04155 ENOG4105QDK Flavodoxin HVW38_RS04160 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVW38_RS04175 ENOG4105EQX glucarate dehydratase HVW38_RS04180 ENOG4105EQX glucarate dehydratase HVW38_RS04185 ENOG4105BZW Glycerate kinase HVW38_RS04190 ENOG4105BZU Histidine kinase HVW38_RS04195 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVW38_RS04200 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVW38_RS04205 ENOG4106A2Z transcriptional regulator antitoxin, MazE HVW38_RS04210 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVW38_RS04215 ENOG4105DXN mazG family HVW38_RS04230 ENOG4105HA9 of methanol dehydrogenase type HVW38_RS04240 ENOG4105HA9 of methanol dehydrogenase type HVW38_RS04250 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVW38_RS04255 ENOG4108CWB sugar kinase ygcE HVW38_RS04260 ENOG4108ITV Inner membrane protein yqcE HVW38_RS04265 ENOG4105CHR reductase HVW38_RS04270 ENOG4107R3A FAD linked oxidase domain protein HVW38_RS04275 ENOG4105C54 Major Facilitator superfamily HVW38_RS04280 ENOG4106IKH Electron transfer flavoprotein HVW38_RS04285 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVW38_RS04290 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVW38_RS04295 ENOG4105WQV ferredoxin-like protein HVW38_RS04300 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVW38_RS04305 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVW38_RS04325 ENOG4105DTT CRISPR-associated helicase, cas3 HVW38_RS04330 ENOG4105CYR Crispr-associated protein, cse1 family HVW38_RS04335 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) HVW38_RS04340 ENOG41060M0 Crispr-associated protein, cse4 family HVW38_RS04345 ENOG4108VWQ crispr-associated protein HVW38_RS04350 ENOG4108Y7V CRISPR-associated protein, Cse3 family HVW38_RS04355 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVW38_RS04360 ENOG4105PWE CRISPR-associated protein cas2 HVW38_RS04365 ENOG4108MXK alkaline phosphatase isozyme conversion HVW38_RS04385 ENOG4105N0Z inner membrane protein ygbE HVW38_RS04420 ENOG4108K5P (LipO)protein HVW38_RS04425 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVW38_RS04435 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVW38_RS04440 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVW38_RS04445 ENOG4105KZM cytoplasmic protein HVW38_RS04450 ENOG4105MEW serine threonine protein phosphatase HVW38_RS04470 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVW38_RS04485 ENOG4105C2J ABC transporter HVW38_RS04490 ENOG4105CNN ABC, transporter HVW38_RS04495 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVW38_RS04500 ENOG4107EDW L-fucose operon activator HVW38_RS04505 ENOG4105VXR cytoplasmic protein HVW38_RS04510 ENOG4105F4R Transcriptional regulator mode HVW38_RS04515 ENOG4108JUA Transcriptional regulator HVW38_RS04520 ENOG4105C45 hydrogenase expression formation protein (HypE) HVW38_RS04525 ENOG4105CQS hydrogenase expression formation protein HypD HVW38_RS04530 ENOG41083WG hydrogenase assembly chaperone HVW38_RS04535 ENOG4107RSS Hydrogenase accessory protein HypB HVW38_RS04540 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVW38_RS04545 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVW38_RS04550 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVW38_RS04555 ENOG4107R30 NADH dehydrogenase HVW38_RS04560 ENOG4107TDF Formate hydrogenlyase subunit 4 HVW38_RS04565 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVW38_RS04570 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVW38_RS04575 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVW38_RS04580 ENOG4105I6X formate hydrogenlyase maturation HVW38_RS04585 ENOG4108MG9 hydrogenase 3 maturation protease HVW38_RS04590 ENOG4105CS2 ec 3.2.1.21 HVW38_RS04595 ENOG4105C5Y PTS System HVW38_RS04600 ENOG4105DDV Transcriptional regulator (LacI family HVW38_RS04605 ENOG4108RC0 Electron transport protein HVW38_RS04610 ENOG4105C8H hydrogenase maturation protein Hypf HVW38_RS04630 ENOG4105C2X Arabinose 5-phosphate isomerase HVW38_RS04640 ENOG4105CVE Lytic murein transglycosylase HVW38_RS04650 ENOG4107TH8 cina domain protein HVW38_RS04670 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVW38_RS04700 ENOG4107VXZ Hydrolase HVW38_RS04705 ENOG4105W39 Membrane HVW38_RS04730 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVW38_RS04735 ENOG4105CW7 secretion protein, HlyD family HVW38_RS04740 ENOG4105NTK Transcriptional repressor Mpra HVW38_RS04745 ENOG4105ZED uncharacterized protein ygaH HVW38_RS04750 ENOG4108UMN azlc family HVW38_RS04760 ENOG4105GIJ Glycine betaine HVW38_RS04765 ENOG4108HQS Glycine betaine HVW38_RS04770 ENOG4108IJ7 Glycine betaine HVW38_RS04775 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVW38_RS04780 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVW38_RS04790 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVW38_RS04795 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVW38_RS04805 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVW38_RS04810 ENOG4108WMJ Protein of unknown function (DUF2002) HVW38_RS04820 ENOG4108X73 DNA- binding protein HVW38_RS04825 ENOG4108V62 Rhodanese domain protein HVW38_RS04830 ENOG41080HT Transcriptional regulator, arsr family HVW38_RS04835 ENOG4105VPI YqaE family transport protein HVW38_RS04840 ENOG4109066 lysm domain bon superfamily protein HVW38_RS04845 ENOG4108PVQ transcriptional regulator HVW38_RS04850 ENOG4105C85 amino acid HVW38_RS04855 ENOG4108JPW Aminotransferase HVW38_RS04860 ENOG4105C26 Dehydrogenase HVW38_RS04865 ENOG4105D5U fad dependent oxidoreductase HVW38_RS04875 ENOG4108NUU Transcriptional regulator HVW38_RS04880 ENOG4105SZ2 membrAne HVW38_RS04885 ENOG4107SNB ankyrin repeat protein YahD HVW38_RS04890 ENOG4105N16 Protein of unknown function (DUF2877) HVW38_RS04895 ENOG4107R1Q Membrane protein FdrA HVW38_RS04900 ENOG4107REC cytoplasmic protein HVW38_RS04905 ENOG4105C5B carbamate kinase HVW38_RS04910 ENOG4105DZC cytosine deaminase HVW38_RS04915 ENOG4105DTA methyltransferase HVW38_RS04925 ENOG4105DQ4 alcohol dehydrogenase HVW38_RS04930 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVW38_RS04935 ENOG4108YZG isomerase HVW38_RS04945 ENOG4105CMT Dihydroxyacetone kinase HVW38_RS04950 ENOG4105CP7 Triose-phosphate isomerase HVW38_RS04955 ENOG4108KFM Xylose Isomerase Domain-Containing protein HVW38_RS04960 ENOG4106J7G oxidoreductase HVW38_RS04965 ENOG4105DKT Transcriptional regulator HVW38_RS04970 ENOG41083A2 UPF0145 protein HVW38_RS04975 ENOG4105Y50 Virulence Protein HVW38_RS04995 ENOG4105F5W AtP-binding protein HVW38_RS05000 ENOG4105D70 Integrase catalytic subunit HVW38_RS05045 ENOG4105DFP Integrase HVW38_RS05060 ENOG4108Z1B Cyclase dehydrase HVW38_RS05070 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVW38_RS05075 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVW38_RS05090 ENOG4108JU6 CBS domain protein HVW38_RS05095 ENOG4106KVJ cytochrome C assembly protein HVW38_RS05100 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVW38_RS05125 ENOG4105QP9 Protein of unknown function (DUF2799) HVW38_RS05130 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVW38_RS05135 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVW38_RS05140 ENOG4105CQC Prephenate dehydratase HVW38_RS05150 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVW38_RS05155 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVW38_RS05160 ENOG4105C34 Pseudouridine synthase HVW38_RS05165 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVW38_RS05170 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVW38_RS05195 ENOG4105CSH Transporter HVW38_RS05200 ENOG4105T42 (LipO)protein HVW38_RS05205 ENOG4105JIM Phosphatidylserine synthase HVW38_RS05210 ENOG4105CD5 CoA-binding domain protein HVW38_RS05215 ENOG4106IUH DTW domain containing protein HVW38_RS05220 ENOG4105K63 Thioredoxin HVW38_RS05225 ENOG4105EIB trna rrna methyltransferase HVW38_RS05250 ENOG4105C1J atp-dependent rna helicase HVW38_RS05260 ENOG4108IYU L-aspartate oxidase HVW38_RS05270 ENOG4105EMN RNA polymerase sigma factor HVW38_RS05275 ENOG41069PW sigma-e factor negative regulatory protein HVW38_RS05280 ENOG4105VQK sigma E regulatory protein, MucB RseB HVW38_RS05285 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVW38_RS05295 ENOG4105C3F Signal peptidase i HVW38_RS05315 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVW38_RS05330 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVW38_RS05335 ENOG4106G6Q Transcriptional regulator HVW38_RS05340 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVW38_RS05345 ENOG4108Z6B deaminase HVW38_RS05355 ENOG4108ETH Formylglycinamide ribotide synthetase HVW38_RS05360 ENOG4107WP9 Histidine kinase HVW38_RS05365 ENOG4108SKK alpha helix protein HVW38_RS05370 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVW38_RS05395 ENOG4107RE1 Inosine-guanosine kinase HVW38_RS05410 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVW38_RS05415 ENOG4105EU0 Major facilitator Superfamily HVW38_RS05420 ENOG4105CGH 5'-nucleotidase HVW38_RS05435 ENOG4108Z66 YbaK ebsC protein HVW38_RS05440 ENOG4105MBR gumn family HVW38_RS05445 ENOG4105C59 p-type ATPase HVW38_RS05450 ENOG4107RY6 amino acid HVW38_RS05480 ENOG4107QZV Type I secretion membrane fusion protein HVW38_RS05485 ENOG4108Z6Z Transcriptional regulator HVW38_RS05490 ENOG4105G5H Membrane HVW38_RS05495 ENOG4107QX8 SPFH domain, Band 7 family protein HVW38_RS05500 ENOG41083J0 (ABC) transporter HVW38_RS05505 ENOG4105C4B ABC transporter, permease HVW38_RS05510 ENOG4107QR8 Thioredoxin HVW38_RS05515 ENOG4105E1F short-chain dehydrogenase reductase HVW38_RS05520 ENOG4108UJV acyl-CoA thioesterase i HVW38_RS05525 ENOG4108I0Y (ABC) transporter HVW38_RS05530 ENOG4105CV6 ABC transporter, permease HVW38_RS05545 ENOG4105G5A Protein of unknown function (DUF2877) HVW38_RS05550 ENOG4105C5B carbamate kinase HVW38_RS05555 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVW38_RS05560 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVW38_RS05570 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVW38_RS05580 ENOG4105S2T inner membrane protein YbcI HVW38_RS05585 ENOG4105WQ3 Rna-binding protein HVW38_RS05600 ENOG4108KU3 Integrase HVW38_RS05655 ENOG4105CKK Glycosyl transferase, family 2 HVW38_RS05660 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVW38_RS05670 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVW38_RS05680 ENOG4108RS6 transposase HVW38_RS05685 ENOG4108SB3 DoxX Family HVW38_RS05690 ENOG4105D8G Major Facilitator superfamily HVW38_RS05695 ENOG4108MN2 Stationary phase inducible protein CsiE HVW38_RS05705 ENOG4105ECY inositol monophosphatase HVW38_RS05725 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVW38_RS05745 ENOG4108ZIT Ferredoxin, 2FE-2S HVW38_RS05750 ENOG4105WVQ Fe-S assembly protein IscX HVW38_RS05760 ENOG4105YYA enhanced serine sensitivity protein SseB HVW38_RS05765 ENOG4105KHC sulfurtransferase HVW38_RS05770 ENOG4105DN3 alpha-2-macroglobulin domain protein HVW38_RS05775 ENOG4108JQB penicillin-binding protein 1C HVW38_RS05805 ENOG4105N21 Membrane HVW38_RS05820 ENOG4105VPD cellular component movement HVW38_RS05845 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVW38_RS05850 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HVW38_RS05860 ENOG41066DY Membrane HVW38_RS05865 ENOG4108ZMA Outer membrane lipoprotein HVW38_RS05870 ENOG41062G3 Protein of unknown function (DUF2633) HVW38_RS05875 ENOG4105BZU Histidine kinase HVW38_RS05880 ENOG4105C9X ppx gppa phosphatase HVW38_RS05885 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVW38_RS05890 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVW38_RS05905 ENOG4105C2W permease HVW38_RS05910 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVW38_RS05915 ENOG4105K89 arsenate reductase HVW38_RS05920 ENOG4105ERG peptidase m48, ste24p HVW38_RS05925 ENOG4105C02 permease HVW38_RS05930 ENOG4108JUA Transcriptional regulator HVW38_RS05935 ENOG4105I6X formate hydrogenlyase maturation HVW38_RS05940 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVW38_RS05950 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVW38_RS05955 ENOG4108JPZ Monovalent cation H antiporter subunit D HVW38_RS05960 ENOG4107WQX hydrogenase 4 membrane subunit HVW38_RS05965 ENOG4105D65 subunit l HVW38_RS05970 ENOG4107TDF Formate hydrogenlyase subunit 4 HVW38_RS05975 ENOG4108JPZ Monovalent cation H antiporter subunit D HVW38_RS05980 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVW38_RS05985 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVW38_RS05990 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVW38_RS06000 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVW38_RS06010 ENOG4105CGZ zinc metallopeptidase HVW38_RS06015 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HVW38_RS06020 ENOG4106KED esterase YpfH HVW38_RS06035 ENOG4105KUZ arsenate reductase HVW38_RS06045 ENOG4105BZS acriflavin resistance protein HVW38_RS06050 ENOG4105BZU Histidine kinase HVW38_RS06055 ENOG4105BZ8 glutamate synthase HVW38_RS06065 ENOG4108PVD exported protein HVW38_RS06070 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVW38_RS06075 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVW38_RS06080 ENOG4105C6K Malic enzyme HVW38_RS06090 ENOG4107H8F HVW38_RS06100 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVW38_RS06110 ENOG4105QZU Inner membrane protein YfeZ HVW38_RS06115 ENOG4105E7K (LipO)protein HVW38_RS06120 ENOG4105EZR dyp-type peroxidase family protein HVW38_RS06125 ENOG4107S1E Beta-lactamase HVW38_RS06130 ENOG4105C5Y PTS System HVW38_RS06145 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVW38_RS06150 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVW38_RS06155 ENOG4108I5D sulfate abc transporter HVW38_RS06160 ENOG4105ECW sulfate abc transporter HVW38_RS06165 ENOG4108IJ6 ABC transporter HVW38_RS06170 ENOG4105C6T cysteine synthase HVW38_RS06175 ENOG4105WEC Molybdate metabolism regulator HVW38_RS06180 ENOG4105M0Y HVW38_RS06190 ENOG4105C5Y PTS System HVW38_RS06195 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVW38_RS06205 ENOG4105C6T cysteine synthase HVW38_RS06215 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HVW38_RS06225 ENOG4105VRT cytoplasmic protein HVW38_RS06230 ENOG4105DHU Bile acid HVW38_RS06235 ENOG4108NFH Sugar hydrolase HVW38_RS06240 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVW38_RS06245 ENOG4105EAA nucleoside HVW38_RS06255 ENOG4105CN8 Transcriptional regulator HVW38_RS06275 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HVW38_RS06280 ENOG4105GXM Putative transcription regulator (DUF1323) HVW38_RS06285 ENOG4105HZG regulatoR HVW38_RS06300 ENOG4108KMM Diguanylate cyclase HVW38_RS06305 ENOG4105D9N nucleoside HVW38_RS06315 ENOG4109076 Conserved Protein HVW38_RS06330 ENOG4105DY9 regulatoR HVW38_RS06335 ENOG4108HRK Histidine kinase HVW38_RS06340 ENOG4105CHM Aminotransferase HVW38_RS06350 ENOG4105D1S lipid A biosynthesis HVW38_RS06355 ENOG4105W9M Membrane HVW38_RS06370 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HVW38_RS06390 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HVW38_RS06400 ENOG4105CHR reductase HVW38_RS06410 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HVW38_RS06425 ENOG4105S64 Formate nitrite transporter HVW38_RS06430 ENOG410903C (LipO)protein HVW38_RS06435 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVW38_RS06440 ENOG4105KZW UPF0381 protein HVW38_RS06455 ENOG4108BY2 phosphohistidine phosphatase HVW38_RS06465 ENOG4106PG1 outer membrane usher protein HVW38_RS06470 ENOG4108FZ9 Chaperone HVW38_RS06475 ENOG4105NEV Fimbrial HVW38_RS06480 ENOG4105UGQ Fimbrial HVW38_RS06485 ENOG4105US4 fimbrial-like protein yfcP HVW38_RS06515 ENOG4105EJ9 Membrane HVW38_RS06520 ENOG4108BPE -transporting atpase HVW38_RS06525 ENOG4105MH2 YfcL protein HVW38_RS06530 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVW38_RS06535 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVW38_RS06540 ENOG4105F9N Major Facilitator Superfamily HVW38_RS06545 ENOG4106WZ1 flagella biosynthesis regulator HVW38_RS06555 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVW38_RS06565 ENOG4105DQR SNARE associated Golgi HVW38_RS06575 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVW38_RS06580 ENOG4108S3P Sporulation domain protein HVW38_RS06585 ENOG4105E96 Colicin v production protein HVW38_RS06590 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVW38_RS06595 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVW38_RS06600 ENOG4105E89 ABC transporter HVW38_RS06605 ENOG4105E89 ABC transporter HVW38_RS06610 ENOG4105DSP amino acid AbC transporter HVW38_RS06615 ENOG4106YG3 ABC transporter HVW38_RS06620 ENOG4108JEH abc transporter atp-binding protein HVW38_RS06625 ENOG4105DNE Transposase HVW38_RS06630 ENOG4105ECP epimerase HVW38_RS06635 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVW38_RS06640 ENOG4105CYM Glutathione S-transferase HVW38_RS06645 ENOG4108SHQ Glutathione S-transferase HVW38_RS06650 ENOG4108RE9 Phosphodiesterase HVW38_RS06655 ENOG4105PTV Nudix Hydrolase HVW38_RS06660 ENOG4105K2J Transcriptional regulator HVW38_RS06675 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVW38_RS06680 ENOG4108HHA Transketolase HVW38_RS06685 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVW38_RS06690 ENOG4105C6K Malic enzyme HVW38_RS06695 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVW38_RS06705 ENOG4105XWI UPF0304 protein HVW38_RS06710 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVW38_RS06715 ENOG4107QWE )-transporter HVW38_RS06720 ENOG4105DK2 UPF0207 protein HVW38_RS06725 ENOG4105CHM Aminotransferase HVW38_RS06730 ENOG4107NQ8 LysR family Transcriptional regulator HVW38_RS06750 ENOG4105GKE subunit e HVW38_RS06755 ENOG4107QIZ NADH dehydrogenase HVW38_RS06760 ENOG4108IEH NADH dehydrogenase subunit g HVW38_RS06775 ENOG4107UFS subunit j HVW38_RS06785 ENOG4105D65 subunit l HVW38_RS06790 ENOG4105C8S subunit m HVW38_RS06800 ENOG4105ZD8 HVW38_RS06810 ENOG4105GDX Domain of unknown function (DUF1877) HVW38_RS06815 ENOG4105CP2 von willebrand factor, type a HVW38_RS06830 ENOG4107YB6 acetyltransferase, (GNAT) family HVW38_RS06835 ENOG4105TNS Conserved Protein HVW38_RS06840 ENOG4105E4F Isochorismate synthase HVW38_RS06855 ENOG4108IPT Naphthoate synthase HVW38_RS06865 ENOG4105CEY Amp-dependent synthetase and ligase HVW38_RS06870 ENOG4106GZG polymyxin resistance protein B HVW38_RS06920 ENOG4108UII YfaZ family HVW38_RS06925 ENOG4108EWA cinA-like protein HVW38_RS06935 ENOG4105DNE Transposase HVW38_RS06940 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVW38_RS06950 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVW38_RS06955 ENOG4105CXY transporter HVW38_RS06960 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVW38_RS06965 ENOG4105FQR PH-inducible protein involved in stress response HVW38_RS06970 ENOG4105XPH Ferredoxin HVW38_RS06975 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVW38_RS06980 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVW38_RS06985 ENOG4107GHC outer membrane autotransporter HVW38_RS06995 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVW38_RS07000 ENOG4105CHU acetyl-coa acetyltransferase HVW38_RS07005 ENOG4105CRW Short chain fatty acid transporter HVW38_RS07010 ENOG4107QNJ CoA-transferase subunit B HVW38_RS07015 ENOG4107QP7 CoA-transferase subunit A HVW38_RS07020 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVW38_RS07025 ENOG4105BZU Histidine kinase HVW38_RS07030 ENOG4105BZU Histidine kinase HVW38_RS07035 ENOG41068CG regulatoR HVW38_RS07040 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVW38_RS07045 ENOG4105FCK Membrane HVW38_RS07050 ENOG4105CJ2 (LipO)protein HVW38_RS07055 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVW38_RS07060 ENOG4105CF1 Alkylated DNA repair protein HVW38_RS07065 ENOG4105IBP Cyclic peptide transporter HVW38_RS07075 ENOG4105CDA abc transporter atp-binding protein HVW38_RS07080 ENOG4105E5Q amino acid AbC transporter HVW38_RS07085 ENOG4107R0W ABC transporter HVW38_RS07095 ENOG4107AQZ Membrane HVW38_RS07100 ENOG4108T1M outer membrane protein x HVW38_RS07105 ENOG4108I6E Sulfatase HVW38_RS07115 ENOG4105KST dependent repressor HVW38_RS07120 ENOG4105F4P )-transporter HVW38_RS07125 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVW38_RS07130 ENOG4105C5H ABC transporter HVW38_RS07135 ENOG4108HCJ Hydrolase HVW38_RS07145 ENOG4105F1A Pyruvate formate-lyase HVW38_RS07150 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVW38_RS07155 ENOG4105D06 uba thif-type nad fad binding protein HVW38_RS07160 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVW38_RS07165 ENOG4108JQ6 ABC transporter HVW38_RS07170 ENOG4105DEF Extracellular solute-binding protein, family 5 HVW38_RS07175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVW38_RS07185 ENOG4105BZU Histidine kinase HVW38_RS07190 ENOG41064RH membrane protein YliF HVW38_RS07200 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVW38_RS07205 ENOG4105D8V Glucose sorbosone dehydrogenase HVW38_RS07210 ENOG4108TGY Glutathione S-transferase HVW38_RS07215 ENOG4105DZ1 carboxypeptidase HVW38_RS07220 ENOG4107FB0 transcriptional regulator DeoR family HVW38_RS07225 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVW38_RS07230 ENOG4107QF7 multi-drug HVW38_RS07240 ENOG4108HCJ Hydrolase HVW38_RS07245 ENOG4106UW1 Major Facilitator superfamily HVW38_RS07250 ENOG4108RFG Tetr family transcriptional regulator HVW38_RS07265 ENOG41090AA HVW38_RS07280 ENOG4105GWF inner membrane protein YbjM HVW38_RS07285 ENOG4108DBC nitroreductase HVW38_RS07295 ENOG4108RMJ sensory transduction regulator HVW38_RS07300 ENOG4107RUE extracellular solute-binding protein family 1 HVW38_RS07305 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVW38_RS07310 ENOG4105F38 ABC transporter, permease HVW38_RS07315 ENOG4105D38 putrescine abc transporter HVW38_RS07320 ENOG4105RBQ inner membrane protein ybjO HVW38_RS07330 ENOG4106TNF Periplasmic binding protein HVW38_RS07335 ENOG4105DMR ABC, transporter HVW38_RS07340 ENOG4105GBT ABC transporter HVW38_RS07345 ENOG4106PMH Extracellular solute-binding protein family 3 HVW38_RS07350 ENOG4105E5Z arginine transporter ATP-binding subunit HVW38_RS07355 ENOG41064MM (LipO)protein HVW38_RS07365 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVW38_RS07370 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVW38_RS07375 ENOG4105CGD Nad-dependent epimerase dehydratase HVW38_RS07380 ENOG4105C5W Aldolase HVW38_RS07385 ENOG4105C7K acetolactate synthase HVW38_RS07395 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVW38_RS07405 ENOG4105DWU Membrane HVW38_RS07410 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVW38_RS07415 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVW38_RS07420 ENOG4108MJ5 VirK protein HVW38_RS07425 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVW38_RS07435 ENOG4105VEQ Cold shock protein HVW38_RS07445 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVW38_RS07455 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVW38_RS07465 ENOG4108JJ8 (ABC) transporter HVW38_RS07470 ENOG4108JJ9 ABC, transporter HVW38_RS07475 ENOG4105C3M thioredoxin reductase HVW38_RS07485 ENOG4105CNU cell division protein FtsK HVW38_RS07495 ENOG4105D1H recombination factor protein RarA HVW38_RS07505 ENOG4105CHJ isochorismatase hydrolase HVW38_RS07515 ENOG4105E5D amino acid HVW38_RS07525 ENOG4105F1A Pyruvate formate-lyase HVW38_RS07530 ENOG4105C6N Formate acetyltransferase HVW38_RS07535 ENOG4105TMB Formate nitrite transporter HVW38_RS07540 ENOG4105DDY UPF0142 protein ycaO HVW38_RS07545 ENOG4107VMU Membrane HVW38_RS07565 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVW38_RS07575 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVW38_RS07580 ENOG4105BZ1 (ABC) transporter HVW38_RS07590 ENOG4105T0Z Conserved Protein HVW38_RS07605 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVW38_RS07610 ENOG4107S90 membrAne HVW38_RS07615 ENOG4106371 Methyltransferase HVW38_RS07625 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVW38_RS07635 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVW38_RS07640 ENOG4105EAQ (twin-arginine translocation) pathway signal HVW38_RS07645 ENOG4105C5X domain protein HVW38_RS07650 ENOG4105CGF Aromatic amino acid aminotransferase HVW38_RS07670 ENOG4105CD8 aminopeptidase N HVW38_RS07675 ENOG4105E2Y ABC, transporter HVW38_RS07680 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVW38_RS07690 ENOG4105GVF (ABC) transporter HVW38_RS07695 ENOG4108UZX fmn reductase HVW38_RS07705 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVW38_RS07710 ENOG4105QVC MOSC domain-containing protein HVW38_RS07720 ENOG4105C5H ABC transporter HVW38_RS07725 ENOG4105F1S paraquat-inducible protein a HVW38_RS07730 ENOG4105DY2 Paraquat-inducible protein b HVW38_RS07735 ENOG4108Q2G (LipO)protein HVW38_RS07740 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVW38_RS07750 ENOG4105DAN ATP-dependent protease HVW38_RS07770 ENOG4108RZ1 DNA transformation protein HVW38_RS07775 ENOG4105EM2 membrane HVW38_RS07780 ENOG410901E Membrane HVW38_RS07785 ENOG41088T4 Helicase IV HVW38_RS07800 ENOG4105K4P CoA-binding domain protein HVW38_RS07815 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVW38_RS07820 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVW38_RS07825 ENOG4108MN8 Membrane HVW38_RS07840 ENOG4105E3S small subunit HVW38_RS07845 ENOG4105DPX Hydrogenase, large subunit HVW38_RS07850 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVW38_RS07855 ENOG4108USZ hydrogenase HVW38_RS07860 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVW38_RS07865 ENOG4105MVP hydrogenase-1 operon protein HyaF HVW38_RS07870 ENOG4106RHG Yeca family HVW38_RS07875 ENOG4105E0U tyrosine-specific transport protein HVW38_RS07880 ENOG4105VVZ metal-binding protein HVW38_RS07885 ENOG41090A1 ferritin HVW38_RS07890 ENOG4105P23 (LipO)protein HVW38_RS07895 ENOG4108UEC Ferritin-like protein HVW38_RS07900 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVW38_RS07905 ENOG4105C2J ABC transporter HVW38_RS07910 ENOG4105CNN ABC, transporter HVW38_RS07915 ENOG4108K4C ec 3.1.3.12 HVW38_RS07925 ENOG4108VA4 Universal stress protein HVW38_RS07935 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVW38_RS07940 ENOG4107RD7 Flagellar Motor Protein, MotA HVW38_RS07945 ENOG4105ER2 Ompa motb domain protein HVW38_RS07950 ENOG4105CBS Chea signal transduction histidine kinase HVW38_RS07955 ENOG4108V3W Chemotaxis protein, CheW HVW38_RS07985 ENOG4105C8Q Methyl-accepting chemotaxis HVW38_RS07990 ENOG4105BZU Histidine kinase HVW38_RS08000 ENOG4108VYJ response regulator receiver protein HVW38_RS08025 ENOG4105MWK D-amino acid dehydrogenase, small subunit HVW38_RS08030 ENOG4105RQF LysR family Transcriptional regulator HVW38_RS08040 ENOG4105D6F Phosphatase HVW38_RS08045 ENOG4105XH3 HVW38_RS08055 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVW38_RS08060 ENOG4108R86 Transcriptional regulator HVW38_RS08065 ENOG4105BZU Histidine kinase HVW38_RS08070 ENOG41064RH membrane protein YliF HVW38_RS08080 ENOG4107EEX Cellulose synthase regulator protein HVW38_RS08090 ENOG41066VF YeeE YedE family protein HVW38_RS08095 ENOG4108W9D (LipO)protein HVW38_RS08100 ENOG4105E5K Alpha-amylase HVW38_RS08105 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HVW38_RS08110 ENOG4105MQ3 flagellar protein FliS HVW38_RS08115 ENOG4105DTS flagellar hook-associated HVW38_RS08125 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVW38_RS08130 ENOG4108M9K flagella biosynthesis protein FliZ HVW38_RS08135 ENOG4105EAB amino acid AbC transporter HVW38_RS08145 ENOG4105E5Q amino acid AbC transporter HVW38_RS08150 ENOG4105CDA abc transporter atp-binding protein HVW38_RS08155 ENOG4105VJY transcriptional regulator HVW38_RS08160 ENOG4105XVG cytoplasmic protein HVW38_RS08165 ENOG4105WH1 Two component transcriptional regulator luxr family HVW38_RS08245 ENOG4108C33 Resolvase HVW38_RS08260 ENOG4108US3 tail fiber assembly HVW38_RS08345 ENOG4105ED4 portal protein HVW38_RS08360 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HVW38_RS08375 ENOG4105VZ1 Replication Protein HVW38_RS08455 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVW38_RS08460 ENOG4107SVH Potassium channel protein HVW38_RS08465 ENOG4105C4M (Ubiquinol oxidase) subunit I HVW38_RS08470 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVW38_RS08485 ENOG4105BZU Histidine kinase HVW38_RS08490 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVW38_RS08495 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVW38_RS08500 ENOG4105CUW cytochrome C-TYPE protein HVW38_RS08505 ENOG4107QY8 reductase HVW38_RS08515 ENOG4105D00 flagellar biosynthetic protein flhB HVW38_RS08520 ENOG4105D7B Flagellar biosynthesis protein flha HVW38_RS08525 ENOG4105W13 flagellar protein HVW38_RS08535 ENOG4106ZCM YecM protein HVW38_RS08555 ENOG4105WJG Glutathione HVW38_RS08560 ENOG41081XQ Conserved Protein HVW38_RS08565 ENOG4105D3W isochorismatase HVW38_RS08575 ENOG4108TIT dATP pyrophosphohydrolase HVW38_RS08580 ENOG4105CDY transcriptional regulatory protein HVW38_RS08590 ENOG4107S01 Repressor protein MetJ HVW38_RS08620 ENOG4105FAV ABC, transporter HVW38_RS08630 ENOG4105NXV High-affinity zinc uptake system protein HVW38_RS08635 ENOG4105DR5 peptidase HVW38_RS08640 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVW38_RS08645 ENOG4105CA9 Pyruvate kinase HVW38_RS08650 ENOG4106KNT transcriptional regulator HVW38_RS08655 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVW38_RS08660 ENOG4105C01 Dihydroxy-acid dehydratase HVW38_RS08665 ENOG4108UHU Aldolase HVW38_RS08670 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HVW38_RS08675 ENOG4105X2V dna damage-inducible protein HVW38_RS08685 ENOG4108Q2J Inner membrane protein YebE HVW38_RS08690 ENOG4105CUG Oligopeptidase b HVW38_RS08695 ENOG4105UMD exodeoxyribonuclease X HVW38_RS08700 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVW38_RS08705 ENOG4105MPK DNA polymerase III subunit theta HVW38_RS08710 ENOG4105FXM Copper resistance protein HVW38_RS08715 ENOG4108PNC copper resistance HVW38_RS08720 ENOG4105NKT exported protein HVW38_RS08725 ENOG4108R1E Serine threonine protein phosphatase 1 HVW38_RS08730 ENOG4105UVW uncharacterized protein yebW HVW38_RS08735 ENOG4105WT8 Protein of unknown function (DUF1480) HVW38_RS08745 ENOG4105DY2 Paraquat-inducible protein b HVW38_RS08750 ENOG4105H2K paraquat-inducible protein a HVW38_RS08755 ENOG4108ZGC gaf domain protein HVW38_RS08765 ENOG4105CN1 protease HVW38_RS08775 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVW38_RS08780 ENOG4105J4Q Transcriptional regulator HVW38_RS08785 ENOG4105TIK HVW38_RS08795 ENOG4105Q3Y exported protein HVW38_RS08810 ENOG4105DHI Methyltransferase HVW38_RS08825 ENOG4105F3R pts system mannose fructose sorbose family iid HVW38_RS08830 ENOG4105ETZ PTS System HVW38_RS08835 ENOG4105DAS pts system HVW38_RS08840 ENOG4105EE5 Membrane protein terC HVW38_RS08845 ENOG4107XTP (EAL) domain protein HVW38_RS08850 ENOG4105EJQ L-serine dehydratase HVW38_RS08860 ENOG4105CRQ synthase (Component I) HVW38_RS08875 ENOG4105V2F Uncharacterized protein yoac HVW38_RS08880 ENOG4105M4H endoribonuclease L-psp HVW38_RS08895 ENOG4105DVT helicase HVW38_RS08900 ENOG41072GX Peptidase M22 Glycoprotease HVW38_RS08905 ENOG4105Y4Z Outer Membrane Lipoprotein HVW38_RS08910 ENOG4105CEY Amp-dependent synthetase and ligase HVW38_RS08915 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVW38_RS08920 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVW38_RS08925 ENOG4108JA2 transcriptioN-repair coupling factor HVW38_RS08930 ENOG4105IQC Inner membrane protein YcfT HVW38_RS08935 ENOG4105D60 lipoprotein releasing system transmembrane protein HVW38_RS08940 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVW38_RS08945 ENOG4105D60 lipoprotein releasing system transmembrane protein HVW38_RS08955 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVW38_RS08970 ENOG4107RUE extracellular solute-binding protein family 1 HVW38_RS08975 ENOG4105D38 putrescine abc transporter HVW38_RS08995 ENOG4105DSB aldose 1-epimerase HVW38_RS09010 ENOG4105VUT cytoplasmic protein HVW38_RS09015 ENOG4108RWI nicotinamidase HVW38_RS09020 ENOG4105HDK L-asparaginase HVW38_RS09030 ENOG4105D07 Signal peptide peptidase, SppA HVW38_RS09035 ENOG41069NU Nitroreductase HVW38_RS09045 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVW38_RS09050 ENOG41065FB inner membrane protein ynji HVW38_RS09055 ENOG4105D82 Glutamate dehydrogenase HVW38_RS09060 ENOG4105MTM Protein of unknown function (DUF1496) HVW38_RS09065 ENOG4105M6F mutator MutT protein HVW38_RS09070 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVW38_RS09075 ENOG4107RM6 sulfurtransferase HVW38_RS09080 ENOG4108VGW abc transporter atp-binding protein HVW38_RS09085 ENOG4105CXZ ABC transporter, permease HVW38_RS09090 ENOG4105VNH ABC transporter solute-binding protein HVW38_RS09095 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVW38_RS09100 ENOG4108N5C SNARE associated Golgi protein-related protein HVW38_RS09105 ENOG4108RSN SNARE associated Golgi HVW38_RS09110 ENOG4105CGK Exodeoxyribonuclease III HVW38_RS09140 ENOG4108SPG Periplasmic Protein HVW38_RS09150 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVW38_RS09160 ENOG4105KKI DNA-binding transcriptional activator OsmE HVW38_RS09165 ENOG4105VZJ PTS System HVW38_RS09170 ENOG4105CK1 PTS System HVW38_RS09175 ENOG4105VCP PTS System HVW38_RS09180 ENOG4105EZV Transcriptional regulator HVW38_RS09185 ENOG4105F8D glycoside hydrolase family 4 HVW38_RS09195 ENOG4105CH6 catalase HVW38_RS09200 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HVW38_RS09205 ENOG4108ETY sodium dicarboxylate symporter HVW38_RS09210 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVW38_RS09215 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVW38_RS09220 ENOG4107PN8 YfeABCD locus regulator HVW38_RS09230 ENOG4105P10 Uncharacterized protein ydiZ HVW38_RS09235 ENOG4105DE4 1-phosphofructokinase HVW38_RS09240 ENOG4108NE3 Salt-induced outer membrane protein HVW38_RS09255 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVW38_RS09260 ENOG41082NX 50s ribosomal protein l35 HVW38_RS09295 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HVW38_RS09300 ENOG4108QBX (LipO)protein HVW38_RS09320 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVW38_RS09330 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVW38_RS09335 ENOG4105SUA Ydil protein HVW38_RS09345 ENOG4105IPI Membrane HVW38_RS09350 ENOG4105CQB FAD linked oxidase domain protein HVW38_RS09355 ENOG4105KA0 thioesterase Superfamily protein HVW38_RS09360 ENOG410671Z uncharacterized protein ydiH HVW38_RS09365 ENOG4108Z4V iron-sulfur cluster assembly HVW38_RS09370 ENOG4105DIW FeS assembly protein SUFB HVW38_RS09375 ENOG4105C3K feS assembly ATPase SufC HVW38_RS09380 ENOG4105JRK feS assembly protein SufD HVW38_RS09395 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVW38_RS09400 ENOG4105KMX major outer membrane lipoprotein HVW38_RS09405 ENOG4105CA9 Pyruvate kinase HVW38_RS09410 ENOG4105RFR Protein of unknown function (DUF2767) HVW38_RS09415 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVW38_RS09420 ENOG4105N0V mono-oxygenase ydhR HVW38_RS09440 ENOG4108R6K riboflavin synthase, subunit alpha HVW38_RS09445 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVW38_RS09450 ENOG4105CZQ inner membrane transport protein YdhC HVW38_RS09455 ENOG4105F52 Transcriptional regulator HVW38_RS09470 ENOG4105F27 Major Facilitator HVW38_RS09475 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVW38_RS09480 ENOG4105K4H Nlp p60 protein HVW38_RS09485 ENOG4105M2J Glutaredoxin HVW38_RS09490 ENOG4107QRT dEAD DEAH box helicase HVW38_RS09495 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HVW38_RS09500 ENOG4108UYE Lactoylglutathione lyase HVW38_RS09505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVW38_RS09510 ENOG4108WUH Transcriptional regulator, TetR family HVW38_RS09515 ENOG4105XZD Fe-S protein HVW38_RS09520 ENOG4107RGM aldo keto reductase HVW38_RS09525 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVW38_RS09530 ENOG4105DSW Fusaric acid resistance protein HVW38_RS09535 ENOG4105Y49 secretion protein, HlyD family HVW38_RS09550 ENOG4108XTF Outer Membrane Lipoprotein HVW38_RS09560 ENOG410642K Lysozyme inhibitor HVW38_RS09575 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVW38_RS09580 ENOG4108K3A Glutathione S-transferase HVW38_RS09585 ENOG4105DUX Transporter HVW38_RS09590 ENOG4105CSM endonuclease III HVW38_RS09600 ENOG4108UQQ Electron transport complex HVW38_RS09610 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVW38_RS09630 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVW38_RS09635 ENOG4106C6R beta-lactam resistance protein HVW38_RS09640 ENOG4105D9R oxidoreductase HVW38_RS09650 ENOG4105C87 Aminotransferase class I and II HVW38_RS09655 ENOG4106J39 exported protein HVW38_RS09660 ENOG4105EIP mannose-6-phosphate isomerase HVW38_RS09665 ENOG4107GFK fumarate HVW38_RS09670 ENOG4105C9Q fumarate hydratase class II HVW38_RS09680 ENOG4105JJR Histidine kinase HVW38_RS09685 ENOG4107EXC regulatoR HVW38_RS09690 ENOG4105RA2 Membrane HVW38_RS09700 ENOG4105D5Q Arginine ornithine antiporter HVW38_RS09705 ENOG4105C5D exported protein HVW38_RS09710 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVW38_RS09715 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVW38_RS09720 ENOG4105BZU Histidine kinase HVW38_RS09725 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVW38_RS09740 ENOG4105D94 Major Facilitator Superfamily HVW38_RS09745 ENOG4106NZI LysR family Transcriptional regulator HVW38_RS09750 ENOG4105DAG ROK family HVW38_RS09755 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVW38_RS09760 ENOG4105CMQ Chloride channel HVW38_RS09765 ENOG4108IJ8 ABC transporter HVW38_RS09770 ENOG4105E90 ABC transporter HVW38_RS09775 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVW38_RS09780 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HVW38_RS09785 ENOG4105R71 cytoplasmic protein HVW38_RS09790 ENOG4108T9Y Inner membrane protein ydcZ HVW38_RS09795 ENOG4108Z7F N-acetyltransferase HVW38_RS09800 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVW38_RS09805 ENOG4108WYP Transcriptional regulator HVW38_RS09810 ENOG4105CHB tonB-dependent Receptor HVW38_RS09815 ENOG4108NS2 receptor HVW38_RS09820 ENOG4105C85 amino acid HVW38_RS09825 ENOG4108N27 Glutathione S-transferase HVW38_RS09835 ENOG4105EUZ Beta-lactamase domain protein HVW38_RS09845 ENOG4108MEJ flavin reductase domain protein HVW38_RS09855 ENOG4105JAB phenazine biosynthesis protein, phzf family HVW38_RS09860 ENOG4105DIA mandelate racemase muconate lactonizing HVW38_RS09875 ENOG4108MEJ flavin reductase domain protein HVW38_RS09880 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVW38_RS09885 ENOG4107HP6 Transcriptional regulator HVW38_RS09890 ENOG4105DTQ mandelate racemase muconate lactonizing HVW38_RS09895 ENOG4105NN7 muconolactone delta-isomerase HVW38_RS09900 ENOG410626B catechol 1,2-dioxygenase HVW38_RS09935 ENOG4105RPH Inner membrane protein YddG HVW38_RS09945 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVW38_RS09950 ENOG4108MG3 formate dehydrogenase HVW38_RS09955 ENOG41084S7 Plasmid maintenance system antidote protein HVW38_RS09965 ENOG4105DQ4 alcohol dehydrogenase HVW38_RS09975 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVW38_RS09980 ENOG4105TPS biofilm-dependent modulation protein HVW38_RS09985 ENOG4108Z9K Osmotically inducible protein HVW38_RS09995 ENOG4105DDW LysR family Transcriptional regulator HVW38_RS10000 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HVW38_RS10010 ENOG4105E32 cytoplasmic protein HVW38_RS10020 ENOG4105Z2P Protein of unknown function (DUF465) HVW38_RS10025 ENOG4108Z9I -acetyltransferase HVW38_RS10030 ENOG4107WE3 acetyltransferase YdcK HVW38_RS10035 ENOG41088CC tellurite resistance protein tehB HVW38_RS10040 ENOG4108KKZ (LipO)protein HVW38_RS10045 ENOG4105CFP Peptidase U32 HVW38_RS10060 ENOG4105RR0 Protein of unknown function (DUF2554) HVW38_RS10065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVW38_RS10070 ENOG4107TYH extracellular solute-binding protein family 1 HVW38_RS10075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVW38_RS10080 ENOG4105D81 ABC transporter, permease HVW38_RS10085 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVW38_RS10100 ENOG410654E Membrane HVW38_RS10105 ENOG4105KBG Protein of unknown function (DUF1161) HVW38_RS10115 ENOG4108MK9 spermidine N(1)-acetyltransferase HVW38_RS10130 ENOG4105CXK mandelate racemase muconate lactonizing HVW38_RS10140 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVW38_RS10150 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVW38_RS10155 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVW38_RS10160 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVW38_RS10175 ENOG41061EV selenium-binding protein YdfZ HVW38_RS10180 ENOG4107XBN GntR Family Transcriptional Regulator HVW38_RS10185 ENOG4105EMU Dehydrogenase HVW38_RS10190 ENOG4105DGW oligopeptidase A HVW38_RS10195 ENOG4108WTK competence damage-inducible protein HVW38_RS10200 ENOG4108YDI single-species biofilm formation on inanimate substrate HVW38_RS10205 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVW38_RS10210 ENOG4105E5W Transporter HVW38_RS10215 ENOG4108594 Permease of the drug metabolite transporter HVW38_RS10220 ENOG4106DNR multiple antibiotic resistance protein HVW38_RS10225 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVW38_RS10230 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVW38_RS10235 ENOG41082NP Multiple antibiotic resistance HVW38_RS10245 ENOG4105EGI Transcriptional regulator HVW38_RS10250 ENOG4105C26 Dehydrogenase HVW38_RS10255 ENOG4105CSV Glutaminase HVW38_RS10260 ENOG4105M0C cytoplasmic protein HVW38_RS10265 ENOG4105BZU Histidine kinase HVW38_RS10275 ENOG4105FFC UPF0187 protein HVW38_RS10285 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVW38_RS10305 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HVW38_RS10320 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HVW38_RS10330 ENOG4108R6W Transcriptional regulator, ARAC family HVW38_RS10335 ENOG4106PHM regulatory protein HVW38_RS10350 ENOG4105CQ0 ABC transporter HVW38_RS10355 ENOG4105PE1 Receptor HVW38_RS10360 ENOG4107RAN Peptidase, M16 HVW38_RS10365 ENOG4105CVK Glutamate decarboxylase HVW38_RS10370 ENOG4105E5D amino acid HVW38_RS10375 ENOG4105F32 YngK protein HVW38_RS10380 ENOG4105BZU Histidine kinase HVW38_RS10385 ENOG4105BZU Histidine kinase HVW38_RS10400 ENOG4105CPW cytochrome b561 HVW38_RS10405 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVW38_RS10410 ENOG4107DB1 DUF218 domain HVW38_RS10425 ENOG4105CQ7 ATP-dependent helicase HVW38_RS10435 ENOG41077RS Phosphatase HVW38_RS10450 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVW38_RS10460 ENOG4107S5I aldo keto reductase HVW38_RS10465 ENOG4108Z0R Transferase HVW38_RS10470 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVW38_RS10475 ENOG4105DZS Phenylacetate-CoA ligase HVW38_RS10480 ENOG4105CHU acetyl-coa acetyltransferase HVW38_RS10485 ENOG4108ZJI phenylacetic acid degradation protein HVW38_RS10490 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVW38_RS10495 ENOG4108UKI Enoyl-CoA hydratase HVW38_RS10500 ENOG4105E39 Enoyl-CoA hydratase HVW38_RS10505 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVW38_RS10510 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVW38_RS10515 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVW38_RS10520 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVW38_RS10525 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVW38_RS10530 ENOG4105DXM phenylacetic acid degradation protein HVW38_RS10535 ENOG4105F11 amine oxidase HVW38_RS10540 ENOG4105C26 Dehydrogenase HVW38_RS10545 ENOG4108WFR AraC Family Transcriptional Regulator HVW38_RS10550 ENOG4105WXT Conserved Protein HVW38_RS10555 ENOG410689M (LipO)protein HVW38_RS10560 ENOG4107H52 Dicarboxylate transport HVW38_RS10565 ENOG4105C5I Dehydrogenase HVW38_RS10570 ENOG41090X5 Heat shock protein hslJ HVW38_RS10575 ENOG4105IKK cytoplasmic protein HVW38_RS10585 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVW38_RS10590 ENOG4105FCK Membrane HVW38_RS10595 ENOG4108RW8 Universal stress protein F HVW38_RS10605 ENOG4105C1J atp-dependent rna helicase HVW38_RS10620 ENOG4105BZU Histidine kinase HVW38_RS10625 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HVW38_RS10630 ENOG4105F2Z 3-oxoadipate enol-lactonase HVW38_RS10635 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HVW38_RS10640 ENOG4105CHU acetyl-coa acetyltransferase HVW38_RS10645 ENOG4107QNJ CoA-transferase subunit B HVW38_RS10655 ENOG4107HP6 Transcriptional regulator HVW38_RS10660 ENOG4108DG9 Smr protein MutS2 HVW38_RS10665 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVW38_RS10670 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVW38_RS10675 ENOG4105Q9Y Universal stress protein HVW38_RS10680 ENOG4105S5I Membrane HVW38_RS10685 ENOG4105D64 Mechanosensitive ion channel HVW38_RS10690 ENOG4107QSI ABC, transporter HVW38_RS10695 ENOG4105KXI murein peptide amidase A HVW38_RS10700 ENOG4107S8C mandelate racemase muconate lactonizing HVW38_RS10705 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVW38_RS10710 ENOG4108JU8 Transcriptional regulator HVW38_RS10720 ENOG4105CM6 amino acid regulated cytosolic protein HVW38_RS10725 ENOG4105K8Z Phage shock protein HVW38_RS10730 ENOG4105NNG Peripheral inner membrane phage-shock protein HVW38_RS10735 ENOG4105FM1 phage shock protein C HVW38_RS10740 ENOG4105YYT phage shock protein B HVW38_RS10745 ENOG41087YS Phage shock protein A HVW38_RS10750 ENOG4105E51 psp operon transcriptional activator HVW38_RS10755 ENOG4108HIY periplasmic HVW38_RS10760 ENOG4108I5W peptide transport system, permease protein HVW38_RS10765 ENOG4108EU3 peptide transport system, permease HVW38_RS10770 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVW38_RS10775 ENOG4108JQ2 peptide transport system atp-binding protein HVW38_RS10780 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVW38_RS10785 ENOG4105Q4T oxidoreductase HVW38_RS10795 ENOG4105BZU Histidine kinase HVW38_RS10805 ENOG4105N2W Transcriptional regulator HVW38_RS10815 ENOG4108ZJT translation initiation factor, Sui1 HVW38_RS10825 ENOG4105CFV Tetratricopeptide repeat protein HVW38_RS10830 ENOG4105Q4A inner membrane protein yciS HVW38_RS10835 ENOG4105EYK Phosphatidylglycerophosphatase B HVW38_RS10845 ENOG4107QM5 aconitate hydratase HVW38_RS10860 ENOG4107R11 Transcriptional regulator HVW38_RS10865 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVW38_RS10870 ENOG4105RKX Protein of unknown function (DUF2498) HVW38_RS10875 ENOG4105ERU peptidase HVW38_RS10880 ENOG4105UBK short-chain dehydrogenase reductase HVW38_RS10885 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVW38_RS10890 ENOG4105FE9 pseudouridine synthase HVW38_RS10900 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVW38_RS10905 ENOG4105DB7 PHP domain protein HVW38_RS10915 ENOG4105CRQ synthase (Component I) HVW38_RS10920 ENOG4108EFP Anthranilate synthase component II HVW38_RS10925 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVW38_RS10940 ENOG4105EIF outer membrane protein W HVW38_RS10945 ENOG4105PI0 Ferredoxin HVW38_RS10960 ENOG4105NAU thioesterase Superfamily protein HVW38_RS10965 ENOG410822N TonB family HVW38_RS10970 ENOG4105K9H YciI-like protein HVW38_RS10990 ENOG4105EYW Ion transport protein HVW38_RS10995 ENOG4108JQ7 (ABC) transporter HVW38_RS11000 ENOG4105C3U ABC transporter HVW38_RS11005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVW38_RS11010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVW38_RS11015 ENOG4107QSI ABC, transporter HVW38_RS11020 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVW38_RS11025 ENOG4105C0A alcohol dehydrogenase HVW38_RS11035 ENOG4107104 thymidine kinase HVW38_RS11045 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVW38_RS11050 ENOG4105I93 response regulator HVW38_RS11055 ENOG4105D78 K07001 NTE family protein HVW38_RS11065 ENOG4105CIY formyltetrahydrofolate deformylase HVW38_RS11110 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVW38_RS11115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVW38_RS11120 ENOG41076YT nitrate reductase, gamma subunit HVW38_RS11125 ENOG4105R3A Nitrate reductase HVW38_RS11130 ENOG4108IUE nitrate reductase beta subunit HVW38_RS11135 ENOG4105CRU nitrate reductase, alpha subunit HVW38_RS11140 ENOG4105DQQ Major facilitator superfamily MFS_1 HVW38_RS11145 ENOG4105BZU Histidine kinase HVW38_RS11150 ENOG4105WH1 Two component transcriptional regulator luxr family HVW38_RS11155 ENOG4105ID0 Putative invasin HVW38_RS11160 ENOG41090EX DsrE family HVW38_RS11165 ENOG4108NH8 Cation transport protein HVW38_RS11170 ENOG4105WS7 Cation transport regulator HVW38_RS11175 ENOG4105EWV Sodium calcium exchanger membrane region HVW38_RS11190 ENOG41063JG Transcriptional regulator HVW38_RS11195 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVW38_RS11220 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVW38_RS11225 ENOG4105CHH sulfate transporter HVW38_RS11230 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVW38_RS11240 ENOG4105C3G gtp-binding protein HVW38_RS11245 ENOG4105E53 ec 3.2.1.28 HVW38_RS11255 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVW38_RS11265 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVW38_RS11275 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVW38_RS11285 ENOG4105ED1 spovr family HVW38_RS11300 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVW38_RS11305 ENOG4105TNG K13735 adhesin invasin HVW38_RS11315 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVW38_RS11330 ENOG4107QMS site-determining protein HVW38_RS11340 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVW38_RS11345 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVW38_RS11350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVW38_RS11360 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVW38_RS11380 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVW38_RS11385 ENOG4105CDY transcriptional regulatory protein HVW38_RS11395 ENOG4105TNG K13735 adhesin invasin HVW38_RS11410 ENOG4105JAB phenazine biosynthesis protein, phzf family HVW38_RS11415 ENOG4108I1J Integrase HVW38_RS11420 ENOG4108HMX isocitrate dehydrogenase (NADP) HVW38_RS11445 ENOG4107QTF adenylosuccinate lyase HVW38_RS11450 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVW38_RS11455 ENOG4105IFJ Histidine kinase HVW38_RS11460 ENOG4105EZE Cupin 4 family protein HVW38_RS11465 ENOG4105CV8 reductase HVW38_RS11470 ENOG4105GNX MltA-interacting MipA family protein HVW38_RS11475 ENOG4105CYN Serine protein kinase HVW38_RS11485 ENOG4106KTS Inner membrane protein yeaI HVW38_RS11490 ENOG4108KHP Diguanylate cyclase HVW38_RS11495 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVW38_RS11510 ENOG4105DJ2 Major Facilitator Superfamily HVW38_RS11515 ENOG4105K78 MarR family Transcriptional regulator HVW38_RS11520 ENOG4105UCG Domain of unknown function (DUF333) HVW38_RS11525 ENOG410620I Diguanylate cyclase HVW38_RS11530 ENOG4106G4W HVW38_RS11540 ENOG4105Y3U Transglycosylase-associated protein HVW38_RS11550 ENOG4107MBR 17 kDa surface antigen HVW38_RS11555 ENOG4105CEP NADH dehydrogenase HVW38_RS11570 ENOG4108RUM thiamine kinase HVW38_RS11575 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVW38_RS11580 ENOG41090DQ Lipoprotein HVW38_RS11585 ENOG4105K59 histidine triad (HIT) protein HVW38_RS11590 ENOG4105CI1 PTS System HVW38_RS11595 ENOG4105F8V Hydrolase, tatD family HVW38_RS11600 ENOG4107QRG dna polymerase iii HVW38_RS11610 ENOG4105HHA aminodeoxychorismate lyase HVW38_RS11615 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVW38_RS11620 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVW38_RS11625 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVW38_RS11630 ENOG4105CHR reductase HVW38_RS11635 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVW38_RS11640 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVW38_RS11650 ENOG4105VGS 50s ribosomal protein l32 HVW38_RS11655 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVW38_RS11660 ENOG4108UHJ MAF-like protein HVW38_RS11665 ENOG4105EI2 Pseudouridine synthase HVW38_RS11670 ENOG4107QQB Ribonuclease E HVW38_RS11675 ENOG4105DTJ flagellar hook-associated protein HVW38_RS11680 ENOG4105E1Q flagellar hook-associated protein HVW38_RS11685 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVW38_RS11700 ENOG4105CGA flagellar basal-body rod protein FlgG HVW38_RS11705 ENOG4108KPB Flagellar basal-body rod protein FlgF HVW38_RS11710 ENOG4105BZE flagellar hook protein, FlgE HVW38_RS11715 ENOG4105W00 Flagellar hook capping protein HVW38_RS11720 ENOG4108ZC9 flagellar basal-body rod protein flgc HVW38_RS11725 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVW38_RS11730 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVW38_RS11735 ENOG4105M9M anti-sigma28 factor FlgM HVW38_RS11740 ENOG4105QVD Flagella synthesis protein FlgN HVW38_RS11745 ENOG4105CJR Integral membrane protein (MviN HVW38_RS11750 ENOG4105EP9 oxidoreductase HVW38_RS11760 ENOG4105D9U N-acetyltransferase HVW38_RS11770 ENOG4105F3T (LipO)protein HVW38_RS11780 ENOG4105MEA DNA damage-inducible protein i HVW38_RS11785 ENOG4105PVA Biofilm formation regulatory protein BssS HVW38_RS11795 ENOG4105DS1 cytochrome b561 HVW38_RS11800 ENOG4108YYC ycei family HVW38_RS11810 ENOG4105D1S lipid A biosynthesis HVW38_RS11820 ENOG4108W47 Acidic protein msyB HVW38_RS11825 ENOG4105NAC (LipO)protein HVW38_RS11830 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVW38_RS11840 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HVW38_RS11845 ENOG4107RZC phospholipase d HVW38_RS11860 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HVW38_RS11865 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVW38_RS11870 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVW38_RS11875 ENOG41086KC Transcriptional regulator HVW38_RS11880 ENOG4108XDW curli assembly protein CsgE HVW38_RS11885 ENOG4108WYR Curli production assembly transport component, CsgF HVW38_RS11890 ENOG4105P8Q Curli production assembly transport component CsgG HVW38_RS11895 ENOG4108UQ5 membrane protein YcdZ HVW38_RS11900 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVW38_RS11930 ENOG4107QUY Guanine deaminase HVW38_RS11935 ENOG4105CRK lysyL-tRNA synthetase HVW38_RS11940 ENOG4105DUX Transporter HVW38_RS11945 ENOG4105CXN decarboxylase HVW38_RS11950 ENOG4105D5Q Arginine ornithine antiporter HVW38_RS11955 ENOG4108M3R transcriptional activator CadC HVW38_RS11960 ENOG4105BZU Histidine kinase HVW38_RS11965 ENOG4108TUY outer membrane protein PgaA HVW38_RS11970 ENOG4107BJW polysaccharide deacetylase HVW38_RS11975 ENOG4105CND Glycosyl transferase, family 2 HVW38_RS11985 ENOG4105D5M phosphate starvation-inducible protein HVW38_RS11990 ENOG4105DBE peroxidase HVW38_RS11995 ENOG410650H (LipO)protein HVW38_RS12005 ENOG4105CK7 Sodium proline symporter HVW38_RS12015 ENOG4105C26 Dehydrogenase HVW38_RS12020 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVW38_RS12025 ENOG4108MJ5 VirK protein HVW38_RS12030 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HVW38_RS12035 ENOG4107BJW polysaccharide deacetylase HVW38_RS12040 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVW38_RS12045 ENOG4105KT5 UmuD protein HVW38_RS12055 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVW38_RS12060 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVW38_RS12065 ENOG41090PJ Flagellar assembly protein HVW38_RS12070 ENOG4108JIR Flagellum-specific ATP synthase HVW38_RS12075 ENOG4105GSA Flagellar export protein flij HVW38_RS12080 ENOG4105WF4 Flagellar hook-length control protein HVW38_RS12085 ENOG4107ZI8 flagellar basal body-associated protein flil HVW38_RS12090 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVW38_RS12095 ENOG4105DD5 Flagellar motor switch protein HVW38_RS12100 ENOG4105K0P flagellar biosynthesis protein HVW38_RS12105 ENOG4105CN7 Flagellar biosynthetic protein FliP HVW38_RS12110 ENOG4105VS8 Flagellar biosynthetic protein fliq HVW38_RS12115 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVW38_RS12120 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVW38_RS12130 ENOG4105YX3 cellular response to acidity HVW38_RS12145 ENOG4105VNZ cytoplasmic protein HVW38_RS12150 ENOG4105CKW Inner membrane protein yedI HVW38_RS12160 ENOG41090BB DNA mismatch endonuclease (vsr) HVW38_RS12165 ENOG4105EST Metal Dependent Phosphohydrolase HVW38_RS12170 ENOG4105Y0K Inner membrane protein YedR HVW38_RS12175 ENOG4105ZIT Porin Gram-negative type HVW38_RS12185 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVW38_RS12230 ENOG4105HVQ Regulatory factor of maltose metabolism HVW38_RS12260 ENOG4107R11 Transcriptional regulator HVW38_RS12305 ENOG4105GMB type VI secretion system effector, hcp1 family HVW38_RS12330 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVW38_RS12380 ENOG4108WC9 type VI secretion system effector, hcp1 family HVW38_RS12385 ENOG4105CS6 Rhs element vgr protein HVW38_RS12405 ENOG410600T transposase HVW38_RS12425 ENOG4105FYV Amp nucleosidase HVW38_RS12430 ENOG4105CSH Transporter HVW38_RS12440 ENOG4105UQX Mate efflux family protein HVW38_RS12465 ENOG4105KNY Microcompartments protein HVW38_RS12470 ENOG4105KNY Microcompartments protein HVW38_RS12475 ENOG4105KNY Microcompartments protein HVW38_RS12480 ENOG4105C0A alcohol dehydrogenase HVW38_RS12490 ENOG4105C0A alcohol dehydrogenase HVW38_RS12495 ENOG4105C6N Formate acetyltransferase HVW38_RS12500 ENOG4105F1A Pyruvate formate-lyase HVW38_RS12505 ENOG4105KNY Microcompartments protein HVW38_RS12510 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVW38_RS12530 ENOG4108PXI ErfK YbiS YcfS YnhG HVW38_RS12535 ENOG4108P62 biosynthesis protein (CbiG) HVW38_RS12540 ENOG4107XVH Transcriptional regulator HVW38_RS12545 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVW38_RS12550 ENOG4105KNY Microcompartments protein HVW38_RS12555 ENOG4105EHR propanediol utilization protein pduB HVW38_RS12560 ENOG4105DMB glycerol dehydratase HVW38_RS12565 ENOG4105YCI dehydratase medium subunit HVW38_RS12570 ENOG4108ZFT Dehydratase small subunit HVW38_RS12575 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVW38_RS12585 ENOG4105KNY Microcompartments protein HVW38_RS12605 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVW38_RS12615 ENOG4108EKI Dehydrogenase HVW38_RS12625 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVW38_RS12635 ENOG4105M3W utilization protein HVW38_RS12640 ENOG4105KTW ethanolamine utilization protein HVW38_RS12655 ENOG4105DR8 Membrane HVW38_RS12665 ENOG4105CJB Exodeoxyribonuclease I HVW38_RS12675 ENOG4105CUC YeeE YedE family protein HVW38_RS12680 ENOG4105CUB amino acid HVW38_RS12690 ENOG4105EQ1 Transcriptional regulator HVW38_RS12695 ENOG4107SRH Nad-dependent epimerase dehydratase HVW38_RS12710 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVW38_RS12720 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVW38_RS12725 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVW38_RS12750 ENOG4105C6Y Udp-glucose 6-dehydrogenase HVW38_RS12755 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVW38_RS12795 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVW38_RS12800 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVW38_RS12805 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVW38_RS12810 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVW38_RS12815 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVW38_RS12820 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVW38_RS12825 ENOG4105G1A colanic acid biosynthesis protein HVW38_RS12830 ENOG4107T8Q Glycosyl transferase (Group 1 HVW38_RS12835 ENOG4105C74 pyruvyl transferase HVW38_RS12840 ENOG4105PSV Polysaccharide Biosynthesis Protein HVW38_RS12845 ENOG4105D3Q Sugar transferase HVW38_RS12850 ENOG4107QKV phosphomannomutase HVW38_RS12855 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVW38_RS12860 ENOG4106CD9 glycosyl transferase group 1 HVW38_RS12865 ENOG4105FGF GDP-mannose mannosyl hydrolase HVW38_RS12870 ENOG4105C30 Nad-dependent epimerase dehydratase HVW38_RS12875 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVW38_RS12880 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVW38_RS12885 ENOG4105ECJ Glycosyl Transferase HVW38_RS12890 ENOG4108NYJ Colanic acid HVW38_RS12895 ENOG4107RXY Glycosyl transferase HVW38_RS12900 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVW38_RS12905 ENOG41090RK glycosyl transferase HVW38_RS12910 ENOG4105D75 Capsular exopolysaccharide family HVW38_RS12915 ENOG4105KJF protein tyrosine phosphatase HVW38_RS12920 ENOG4105DAY polysaccharide export protein HVW38_RS12930 ENOG4105EE5 Membrane protein terC HVW38_RS12945 ENOG4108GAE asmA family HVW38_RS12960 ENOG4105BZU Histidine kinase HVW38_RS12965 ENOG4105D03 DNA-3-methyladenine glycosylase II HVW38_RS12970 ENOG4105R8A Heat shock protein HVW38_RS12975 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVW38_RS12980 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HVW38_RS12985 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVW38_RS12990 ENOG4108M24 von Willebrand factor, type A HVW38_RS13000 ENOG4105ENT Efflux transporter rnd family, mfp subunit HVW38_RS13020 ENOG4105EB3 Histidine kinase HVW38_RS13025 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVW38_RS13030 ENOG4105KWI UPF0339 protein HVW38_RS13035 ENOG4105X54 addiction module antidote protein HVW38_RS13045 ENOG4105CFP Peptidase U32 HVW38_RS13055 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVW38_RS13060 ENOG4105IE8 Alpha-ketoglutarate permease HVW38_RS13065 ENOG4105CMG Carbohydrate kinase HVW38_RS13070 ENOG4105DEI Mannitol dehydrogenase HVW38_RS13090 ENOG4105EF1 ribulokinase HVW38_RS13095 ENOG4105IE8 Alpha-ketoglutarate permease HVW38_RS13100 ENOG4105EIE fructose-bisphosphate aldolase HVW38_RS13105 ENOG4105EAA nucleoside HVW38_RS13110 ENOG4108KD5 ADP-ribosylation crystallin J1 HVW38_RS13115 ENOG4108TFM Kinase, PfkB family HVW38_RS13120 ENOG4105FDP GntR family transcriptional regulator HVW38_RS13125 ENOG4108UQ1 hydrolase, family 25 HVW38_RS13130 ENOG4105DWF phosphomethylpyrimidine kinase HVW38_RS13140 ENOG4105CAR Terminase, large subunit HVW38_RS13245 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVW38_RS13250 ENOG410662B Type-1 fimbrial protein HVW38_RS13255 ENOG4105CW0 outer membrane usher protein HVW38_RS13260 ENOG4108MQF Chaperone HVW38_RS13270 ENOG41067AK Protein of unknown function (DUF2574) HVW38_RS13275 ENOG4105D1F ATP-binding protein HVW38_RS13285 ENOG4108KDT Molybdate metabolism regulator HVW38_RS13290 ENOG4108KDT Molybdate metabolism regulator HVW38_RS13295 ENOG4108KDT Molybdate metabolism regulator HVW38_RS13300 ENOG4108KDT Molybdate metabolism regulator HVW38_RS13310 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVW38_RS13315 ENOG4105RD5 HVW38_RS13320 ENOG4105DEG Vwa containing coxe family protein HVW38_RS13325 ENOG410903U zinc ion binding HVW38_RS13330 ENOG4108YCW (LipO)protein HVW38_RS13335 ENOG4108W15 Protein of unknown function (DUF1456) HVW38_RS13340 ENOG4108NEV two component transcriptional regulator, LytTR family HVW38_RS13345 ENOG4108HRK Histidine kinase HVW38_RS13350 ENOG4108XDN Transcriptional regulator HVW38_RS13360 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVW38_RS13365 ENOG4108IJ8 ABC transporter HVW38_RS13370 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVW38_RS13375 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVW38_RS13380 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVW38_RS13385 ENOG4105CXG d-lactate dehydrogenase HVW38_RS13390 ENOG41061WM D-Alanyl-D-Alanine HVW38_RS13395 ENOG41069YE inner membrane protein yohC HVW38_RS13400 ENOG4105KHU inner membrane protein YohD HVW38_RS13405 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVW38_RS13415 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVW38_RS13425 ENOG41067MG lrgb family HVW38_RS13435 ENOG4107GZ4 SanA protein HVW38_RS13440 ENOG4105Y9N Membrane HVW38_RS13445 ENOG4105BZ8 glutamate synthase HVW38_RS13450 ENOG4107SJI Dehydrogenase HVW38_RS13455 ENOG4108HWV )-transporter HVW38_RS13460 ENOG4105C2J ABC transporter HVW38_RS13465 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVW38_RS13470 ENOG41060NJ transcriptional regulator HVW38_RS13475 ENOG4105DHF Membrane HVW38_RS13490 ENOG4105D05 Receptor HVW38_RS13495 ENOG4108IQI permease HVW38_RS13500 ENOG4105DUM transcriptional regulator, lysR family HVW38_RS13505 ENOG4105HMI Membrane HVW38_RS13515 ENOG4105DD7 kinase (PfkB family HVW38_RS13520 ENOG4105D9N nucleoside HVW38_RS13530 ENOG4108Y4K DNA-binding transcriptional activator HVW38_RS13535 ENOG4105D9N nucleoside HVW38_RS13540 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVW38_RS13545 ENOG4105DD7 kinase (PfkB family HVW38_RS13550 ENOG4105DM4 PTS System HVW38_RS13555 ENOG4105DE4 1-phosphofructokinase HVW38_RS13560 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVW38_RS13565 ENOG4105S8Q sugar efflux transporter HVW38_RS13570 ENOG4105KRS Proteinase inhibitor HVW38_RS13580 ENOG4105DEI Mannitol dehydrogenase HVW38_RS13585 ENOG4105CKI cobalamin synthesis protein HVW38_RS13590 ENOG41076MN Phosphoesterase, PA-phosphatase related HVW38_RS13595 ENOG4107TT5 NLP P60 protein HVW38_RS13600 ENOG4105CXC rtn protein HVW38_RS13605 ENOG4105E43 Extracellular solute-binding protein, family 5 HVW38_RS13610 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVW38_RS13615 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVW38_RS13620 ENOG4108JQ5 ABC transporter HVW38_RS13625 ENOG4105HG6 HVW38_RS13630 ENOG4105C2C drug resistance transporter, Bcr CflA HVW38_RS13635 ENOG4105I08 Pseudouridine synthase HVW38_RS13640 ENOG4105CFI type iii restriction protein res subunit HVW38_RS13665 ENOG4105E68 Sulfatase HVW38_RS13680 ENOG410658X HVW38_RS13685 ENOG4105WH1 Two component transcriptional regulator luxr family HVW38_RS13690 ENOG4105KWW Biogenesis protein HVW38_RS13695 ENOG4107QX9 Thiol disulfide interChange protein HVW38_RS13700 ENOG4105DA4 cytochrome c-type biogenesis protein HVW38_RS13710 ENOG4105X3C heme exporter protein HVW38_RS13715 ENOG41060IM Heme exporter protein HVW38_RS13720 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVW38_RS13725 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HVW38_RS13730 ENOG4105CUW cytochrome C-TYPE protein HVW38_RS13735 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVW38_RS13740 ENOG4105GXZ Ferredoxin-type protein NapH HVW38_RS13745 ENOG4108BGM Quinol dehydrogenase periplasmic component HVW38_RS13755 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVW38_RS13760 ENOG4108ZNS ferredoxin-type protein NapF HVW38_RS13770 ENOG4105D8X mechanosensitive ion channel HVW38_RS13780 ENOG4105ZY9 UPF0379 protein ybiM HVW38_RS13785 ENOG4108IU3 tonb-dependent siderophore receptor HVW38_RS13795 ENOG4105KSC Transcriptional regulator, TraR DksA family HVW38_RS13800 ENOG4105VR4 UPF0379 protein ybiJ HVW38_RS13805 ENOG4105DG4 malate L-lactate dehydrogenase HVW38_RS13810 ENOG4108MTB glycosyl transferase family HVW38_RS13815 ENOG4105DVT helicase HVW38_RS13820 ENOG4105C1J atp-dependent rna helicase HVW38_RS13825 ENOG4107MVR Transcriptional regulator HVW38_RS13835 ENOG4105CJ1 ABC, transporter HVW38_RS13840 ENOG4107QWP ABC-2 type transporter HVW38_RS13845 ENOG4107QWP ABC-2 type transporter HVW38_RS13850 ENOG4105I9U inner membrane protein ybhQ HVW38_RS13855 ENOG4105X23 Endonuclease Exonuclease phosphatase HVW38_RS13860 ENOG4105DZQ phospholipase D Transphosphatidylase HVW38_RS13865 ENOG4107UXM Membrane HVW38_RS13870 ENOG410733J conserved inner membrane protein HVW38_RS13885 ENOG4105HFZ Membrane HVW38_RS13890 ENOG4108ZAF Molybdopterin HVW38_RS13895 ENOG4105M00 molybdopterin converting factor, subunit 1 HVW38_RS13905 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVW38_RS13915 ENOG4105CHW UPF0052 protein HVW38_RS13925 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVW38_RS13930 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVW38_RS13945 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVW38_RS13950 ENOG4108V1U phospholipid-binding protein HVW38_RS13955 ENOG4105NBR Pectinesterase HVW38_RS13965 ENOG4108K4B hydrolase HVW38_RS13975 ENOG4105E0C molybdate abc transporter HVW38_RS13980 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVW38_RS13990 ENOG4105F4R Transcriptional regulator mode HVW38_RS13995 ENOG4105DKW ABC transporter HVW38_RS14000 ENOG4105CMR udp-glucose 4-epimerase HVW38_RS14005 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVW38_RS14015 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVW38_RS14025 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVW38_RS14030 ENOG4105JND homeobox protein HVW38_RS14035 ENOG4105PGM cation diffusion facilitator family transporter HVW38_RS14040 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVW38_RS14100 ENOG4105UFD tol-pal system protein YbgF HVW38_RS14105 ENOG4105KCK Peptidoglycan-associated lipoprotein HVW38_RS14115 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVW38_RS14125 ENOG4105E02 MotA TolQ exbB proton channel HVW38_RS14130 ENOG4107YD3 Thioesterase HVW38_RS14135 ENOG4105KJB cyd operon protein YbgE HVW38_RS14145 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVW38_RS14150 ENOG4105C4M (Ubiquinol oxidase) subunit I HVW38_RS14155 ENOG4105C8I hydrolase, family 38 HVW38_RS14160 ENOG4105DM4 PTS System HVW38_RS14165 ENOG4105FDP GntR family transcriptional regulator HVW38_RS14170 ENOG4107WFU Glutamate mutase subunit sigma HVW38_RS14180 ENOG4105DJI Methylaspartate mutase, E subunit HVW38_RS14205 ENOG4107GFK fumarate HVW38_RS14210 ENOG4105ETT transcriptional Regulator, LysR family HVW38_RS14215 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVW38_RS14225 ENOG4105C7S Dehydrogenase HVW38_RS14230 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVW38_RS14235 ENOG4105E33 succinate dehydrogenase HVW38_RS14240 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVW38_RS14245 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVW38_RS14250 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVW38_RS14255 ENOG4105BZN citrate synthase HVW38_RS14260 ENOG4106UBK fimbrial-like adhesin protein HVW38_RS14265 ENOG4106PG1 outer membrane usher protein HVW38_RS14270 ENOG4108TTM chaperone HVW38_RS14275 ENOG4108MY7 Fimbrial HVW38_RS14280 ENOG4108KK1 membrane protein AbrB duplication HVW38_RS14305 ENOG4107R7A Allophanate hydrolase subunit 2 HVW38_RS14310 ENOG4105P4J Allophanate hydrolase, subunit 1 HVW38_RS14315 ENOG4107QNR UPF0135 protein HVW38_RS14320 ENOG4105DUX Transporter HVW38_RS14325 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVW38_RS14330 ENOG4107SEY Conserved Protein HVW38_RS14335 ENOG4105XIQ Protein of unknown function (DUF2517) HVW38_RS14360 ENOG4105C08 Histidine kinase HVW38_RS14365 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVW38_RS14370 ENOG4105CXN decarboxylase HVW38_RS14375 ENOG4105D5Q Arginine ornithine antiporter HVW38_RS14380 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVW38_RS14385 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVW38_RS14390 ENOG4105EV9 Alpha Beta Hydrolase HVW38_RS14395 ENOG4105NNH LexA regulated protein HVW38_RS14400 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVW38_RS14410 ENOG41090R7 Ferric uptake HVW38_RS14415 ENOG4105GX6 (LipO)protein HVW38_RS14430 ENOG4105CI1 PTS System HVW38_RS14440 ENOG4105CE4 GlcNAc 6-P deacetylase HVW38_RS14445 ENOG4105E2R ROK family HVW38_RS14450 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVW38_RS14455 ENOG4105CAQ asparagine synthetase HVW38_RS14500 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVW38_RS14510 ENOG4105C9A Phoh family HVW38_RS14520 ENOG4108JU5 Magnesium and cobalt efflux protein HVW38_RS14525 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVW38_RS14530 ENOG4107U91 Rhomboid family HVW38_RS14535 ENOG4107RP9 extracellular solute-binding protein, family 3 HVW38_RS14540 ENOG4105EAD ABC transporter HVW38_RS14545 ENOG4105DRP amino acid AbC transporter HVW38_RS14550 ENOG4105CDA abc transporter atp-binding protein HVW38_RS14570 ENOG4107PAI alpha helical protein HVW38_RS14585 ENOG4105DJF DNA polymerase III, delta' subunit HVW38_RS14595 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVW38_RS14605 ENOG4105CJN penicillin-binding protein HVW38_RS14610 ENOG4105CNI cell division protein FtsW HVW38_RS14615 ENOG4105K6T rare lipoprotein A HVW38_RS14620 ENOG4105DZ1 carboxypeptidase HVW38_RS14630 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HVW38_RS14660 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVW38_RS14665 ENOG4105CEE C4-dicarboxylate transporter HVW38_RS14670 ENOG4105KTS ribonuclease HVW38_RS14675 ENOG4105NXH GreA GreB family elongation factor HVW38_RS14680 ENOG4108U51 Universal stress protein HVW38_RS14685 ENOG4108JU3 Alkyl hydroperoxide reductase HVW38_RS14690 ENOG4105D3R alkyl hydroperoxide reductase HVW38_RS14695 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVW38_RS14700 ENOG4105DQS Transcriptional regulator HVW38_RS14705 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVW38_RS14710 ENOG4105GTN ParB Domain Protein Nuclease HVW38_RS14715 ENOG4105CHM Aminotransferase HVW38_RS14720 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVW38_RS14725 ENOG4105VCD cytoplasmic protein HVW38_RS14730 ENOG4105D22 carbon starvation protein HVW38_RS14735 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVW38_RS14740 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVW38_RS14745 ENOG4105WQI isochorismatase HVW38_RS14750 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVW38_RS14755 ENOG4105E4F Isochorismate synthase HVW38_RS14760 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVW38_RS14770 ENOG4105DQ5 transport system permease protein HVW38_RS14775 ENOG4105TVJ transport system, permease HVW38_RS14780 ENOG4105E0A ABC, transporter HVW38_RS14800 ENOG4105C0W non-ribosomal peptide synthetase HVW38_RS14805 ENOG41085A6 mbth domain-containing protein HVW38_RS14810 ENOG4105E93 esterase HVW38_RS14815 ENOG4107RNH Outer membrane receptor FepA HVW38_RS14820 ENOG4108TSE Transferase HVW38_RS14835 ENOG4107635 Hok Gef family protein HVW38_RS14845 ENOG4105WQ6 Membrane HVW38_RS14850 ENOG4105MSB protein, conserved in bacteria HVW38_RS14855 ENOG4108RCM Nitroreductase HVW38_RS14860 ENOG4105CUY Mechanosensitive ion channel HVW38_RS14865 ENOG4105C85 amino acid HVW38_RS14870 ENOG4108IJF Heavy metal efflux pump, CzcA HVW38_RS14875 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVW38_RS14880 ENOG410624V efflux system protein HVW38_RS14885 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVW38_RS14890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVW38_RS14895 ENOG4105GR3 Histidine kinase HVW38_RS14930 ENOG4107QMP dna polymerase iii subunits gamma and tau HVW38_RS14940 ENOG4105WD1 Membrane HVW38_RS14945 ENOG4108URS primosomal replication protein n'' HVW38_RS14950 ENOG4106428 Protein of unknown function (DUF2496) HVW38_RS14955 ENOG4105EGS Mechanosensitive ion channel HVW38_RS14960 ENOG4107XI7 Tetr family transcriptional regulator HVW38_RS14965 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVW38_RS14970 ENOG4105BZS acriflavin resistance protein HVW38_RS14975 ENOG4108UKR Biofilm formation regulator YbaJ HVW38_RS14985 ENOG4105GSJ Inner membrane protein ylaC HVW38_RS14990 ENOG41066DG (EAL) domain protein HVW38_RS14995 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVW38_RS15005 ENOG41080UX Methyltransferase HVW38_RS15010 ENOG4108MNP Glycoprotein polysaccharide metabolism HVW38_RS15015 ENOG4105C29 acyl-CoA thioesterase HVW38_RS15020 ENOG4105BZU Histidine kinase HVW38_RS15025 ENOG4108YZA Nitrogen regulatory protein pii HVW38_RS15030 ENOG4105BZ1 (ABC) transporter HVW38_RS15035 ENOG4105BZ1 (ABC) transporter HVW38_RS15040 ENOG4108XM1 transcriptional regulator AsnC family HVW38_RS15050 ENOG4108NFA extracellular solute-binding protein HVW38_RS15060 ENOG4108TGP Thioesterase superfamily protein HVW38_RS15065 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVW38_RS15070 ENOG4105EIN peptidylprolyl cis-trans isomerase HVW38_RS15075 ENOG4105K70 DNA-binding protein HVW38_RS15080 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVW38_RS15100 ENOG4105M85 Bola protein HVW38_RS15105 ENOG4105IEY (LipO)protein HVW38_RS15110 ENOG4105EYM Major Facilitator superfamily HVW38_RS15115 ENOG4105E2S oxidase) subunit II HVW38_RS15120 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVW38_RS15125 ENOG4105CCU oxidase (Subunit III) HVW38_RS15130 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVW38_RS15145 ENOG4107HP6 Transcriptional regulator HVW38_RS15150 ENOG4107V59 shikimate HVW38_RS15155 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVW38_RS15165 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVW38_RS15175 ENOG4105D2S major facilitator superfamily HVW38_RS15180 ENOG4107RDB Major Facilitator HVW38_RS15190 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVW38_RS15195 ENOG4107S0N DJ-1 family HVW38_RS15210 ENOG4105CTB Polyprenyl synthetase HVW38_RS15215 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVW38_RS15220 ENOG4105CPC Aldo Keto reductase HVW38_RS15225 ENOG4108ZAI phosphatidylglycerophosphatase a HVW38_RS15230 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVW38_RS15240 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVW38_RS15245 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVW38_RS15255 ENOG4108KIC (LipO)protein HVW38_RS15260 ENOG4105DRB nucleoside-specific channel-forming protein HVW38_RS15265 ENOG4105N1F Hnh endonuclease HVW38_RS15270 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVW38_RS15275 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVW38_RS15280 ENOG4105VIE preprotein translocase, subunit YajC HVW38_RS15300 ENOG4107R28 alpha amylase, catalytic region HVW38_RS15305 ENOG4105C85 amino acid HVW38_RS15310 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVW38_RS15315 ENOG4105BZU Histidine kinase HVW38_RS15325 ENOG4107RH8 nuclease SbcCD subunit D HVW38_RS15330 ENOG4105EYH Exonuclease HVW38_RS15335 ENOG4105DKQ ROK family HVW38_RS15350 ENOG4105HBA AroM protein HVW38_RS15355 ENOG4105SS3 HVW38_RS15370 ENOG4105II7 pyrroline-5-carboxylate reductase HVW38_RS15375 ENOG4105BZU Histidine kinase HVW38_RS15380 ENOG4105VIF phosphate starvation-inducible protein HVW38_RS15395 ENOG4105CPF Cell wall formation (By similarity) HVW38_RS15400 ENOG4105UNH Membrane HVW38_RS15405 ENOG4105FR5 inner membrane protein YaiY HVW38_RS15410 ENOG4107QS8 (LipO)protein HVW38_RS15415 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVW38_RS15420 ENOG4107R6D beta-lactam binding protein AmpH HVW38_RS15425 ENOG4108PNB DNA-binding transcriptional regulator HVW38_RS15430 ENOG4108NSE outer membrane autotransporter barrel HVW38_RS15435 ENOG4105D52 delta-aminolevulinic acid dehydratase HVW38_RS15440 ENOG4105E2B Taurine dioxygenase HVW38_RS15445 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVW38_RS15450 ENOG4108IY8 ABC, transporter HVW38_RS15455 ENOG4106FTQ Taurine ABC transporter, periplasmic HVW38_RS15460 ENOG4107W19 lmbE family HVW38_RS15470 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVW38_RS15475 ENOG4105DXD 2-methylcitrate dehydratase HVW38_RS15480 ENOG4105BZN citrate synthase HVW38_RS15485 ENOG4105CR4 methylisocitrate lyase HVW38_RS15490 ENOG4108JU7 Transcriptional regulator HVW38_RS15495 ENOG4105TDT uncharacterized protein yahO HVW38_RS15500 ENOG4105E82 cytochrome subunit of dehydrogenase HVW38_RS15505 ENOG4105BZU Histidine kinase HVW38_RS15510 ENOG4105C6F GntR Family Transcriptional Regulator HVW38_RS15515 ENOG4105CPQ Dehydrogenase HVW38_RS15520 ENOG4108I5G Major Facilitator superfamily HVW38_RS15525 ENOG4105BZU Histidine kinase HVW38_RS15535 ENOG4105BZU Histidine kinase HVW38_RS15540 ENOG4108HF7 Gcn5-related n-acetyltransferase HVW38_RS15550 ENOG4107SET aldo keto reductase HVW38_RS15555 ENOG4105EQ2 LysR family Transcriptional regulator HVW38_RS15665 ENOG4105UZW Tail fiber assembly protein HVW38_RS15670 ENOG410685N tail fiber protein HVW38_RS15775 ENOG4105QYK bacteriophage lambda Bor protein homolog HVW38_RS15785 ENOG4105KUS lysozyme HVW38_RS15790 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVW38_RS15795 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HVW38_RS15800 ENOG4107SEY Conserved Protein HVW38_RS15810 ENOG4105HRS Antitermination protein HVW38_RS15825 ENOG4105RWQ Protein of unknown function (DUF1364) HVW38_RS15830 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVW38_RS15835 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVW38_RS15935 ENOG4108KU3 Integrase HVW38_RS15955 ENOG4105FCK Membrane HVW38_RS15975 ENOG4105CIN aminoacyl-histidine dipeptidase HVW38_RS15990 ENOG4108S2Y peptide Chain Release factor HVW38_RS16000 ENOG4108HYG acetyltransferase HVW38_RS16020 ENOG4107QYX exodeoxyribonuclease v alpha HVW38_RS16025 ENOG4107QKA exodeoxyribonuclease V beta HVW38_RS16030 ENOG4107QXK peptidase HVW38_RS16035 ENOG4105DSY exodeoxyribonuclease V, gamma HVW38_RS16040 ENOG4105RVB Prepilin peptidase dependent protein c HVW38_RS16045 ENOG4105SEN Protein of unknown function (DUF2509) HVW38_RS16055 ENOG4105IPU prepilin peptidase dependent protein A HVW38_RS16070 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVW38_RS16085 ENOG4105EE5 Membrane protein terC HVW38_RS16090 ENOG4105SUV lipoprotein YgdR HVW38_RS16095 ENOG4105CPC Aldo Keto reductase HVW38_RS16120 ENOG41060NJ transcriptional regulator HVW38_RS16130 ENOG4105RQF LysR family Transcriptional regulator HVW38_RS16135 ENOG4105CHU acetyl-coa acetyltransferase HVW38_RS16140 ENOG4108MHD transport protein HVW38_RS16145 ENOG4105ISV protein with bipartite regulator domain HVW38_RS16150 ENOG4108TC1 Transcriptional regulator HVW38_RS16160 ENOG410802X bacteriophage n4 adsorption protein b HVW38_RS16170 ENOG4105QUW HVW38_RS16175 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVW38_RS16180 ENOG4105DZC cytosine deaminase HVW38_RS16200 ENOG4105TNG K13735 adhesin invasin HVW38_RS16215 ENOG4108K5P (LipO)protein HVW38_RS16220 ENOG4105MP9 class II Aldolase HVW38_RS16240 ENOG4105C5Q Transcriptional regulator HVW38_RS16245 ENOG4105H3G oxidoreductase HVW38_RS16250 ENOG4105KME endoribonuclease L-psp HVW38_RS16260 ENOG4105CWC Acetylornithine deacetylase HVW38_RS16265 ENOG4105CVK Glutamate decarboxylase HVW38_RS16270 ENOG4105CSV Glutaminase HVW38_RS16275 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVW38_RS16280 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVW38_RS16285 ENOG4105C7W Xanthine dehydrogenase HVW38_RS16290 ENOG4107XAN XdhC and CoxI family HVW38_RS16305 ENOG4105CRK lysyL-tRNA synthetase HVW38_RS16315 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVW38_RS16320 ENOG4105T95 Thiol disulfide interChange protein HVW38_RS16325 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVW38_RS16330 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVW38_RS16335 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVW38_RS16340 ENOG4105Y75 tpr repeat protein HVW38_RS16350 ENOG4108UT2 hemolysin iii HVW38_RS16355 ENOG4105N5Z UPF0267 protein HVW38_RS16360 ENOG4105CS2 ec 3.2.1.21 HVW38_RS16390 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVW38_RS16395 ENOG4105D0A hydroxylase HVW38_RS16400 ENOG4107RAQ aminopeptidase HVW38_RS16420 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVW38_RS16430 ENOG4108JQ1 Dehydrogenase HVW38_RS16445 ENOG4105MPN Membrane HVW38_RS16450 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVW38_RS16455 ENOG4105D64 Mechanosensitive ion channel HVW38_RS16460 ENOG4105D2N Aldolase HVW38_RS16475 ENOG4107Z1W Fructose transport system kinase HVW38_RS16480 ENOG4108R4K DNA-binding, transcriptional regulator HVW38_RS16485 ENOG4108Q8A Fructose-1,6-bisphosphatase HVW38_RS16490 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVW38_RS16495 ENOG4105CTS PTS system mannitol-specific HVW38_RS16500 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVW38_RS16505 ENOG4105EPW hflc protein HVW38_RS16510 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVW38_RS16515 ENOG4108K0D peptidase, M48 HVW38_RS16525 ENOG4105CXK mandelate racemase muconate lactonizing HVW38_RS16530 ENOG4105CZE histidine utilization repressor HVW38_RS16535 ENOG4105CHR reductase HVW38_RS16540 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVW38_RS16550 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVW38_RS16555 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVW38_RS16580 ENOG4107QNK )-transporter HVW38_RS16590 ENOG4105RWS endonuclease I HVW38_RS16595 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVW38_RS16600 ENOG4105D7Z glutathione synthase HVW38_RS16615 ENOG4105CZX twitching motility protein HVW38_RS16620 ENOG4105DFA alanine racemase domain protein HVW38_RS16625 ENOG4108VIA integral membrane protein HVW38_RS16635 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVW38_RS16640 ENOG4105CSA Coproporphyrinogen iii oxidase HVW38_RS16645 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVW38_RS16650 ENOG41069H7 transport system small permease component HVW38_RS16655 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVW38_RS16660 ENOG4106MH3 alpha helix chain HVW38_RS16665 ENOG4105HDK L-asparaginase HVW38_RS16670 ENOG4105K33 Periplasmic Protein HVW38_RS16675 ENOG41090ED Protein with unknown function (DUF469) HVW38_RS16685 ENOG4105CEN a g-specific adenine glycosylase HVW38_RS16700 ENOG4105EAA nucleoside HVW38_RS16705 ENOG4105CXN decarboxylase HVW38_RS16710 ENOG4108UQV Membrane HVW38_RS16745 ENOG4105C2X Arabinose 5-phosphate isomerase HVW38_RS16750 ENOG4105ECX polysaccharide export HVW38_RS16755 ENOG4107V1M polysaccharide export protein HVW38_RS16760 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HVW38_RS16765 ENOG4105E12 capsule polysaccharide HVW38_RS16770 ENOG41084CK capsule polysaccharide HVW38_RS16795 ENOG41090SZ ABC-2 type transporter HVW38_RS16800 ENOG4105U1E general secretion pathway protein M HVW38_RS16810 ENOG4105D70 Integrase catalytic subunit HVW38_RS16815 ENOG4105F5W AtP-binding protein HVW38_RS16835 ENOG4108NDC ATP-binding protein yghS HVW38_RS16840 ENOG4108GH0 ATP-binding protein yghT HVW38_RS16850 ENOG4105D5K Hemolysin activator protein HVW38_RS16945 ENOG4105F4K antigen 43 HVW38_RS16950 ENOG4108PZQ Inner membrane protein YeeR HVW38_RS16965 ENOG4106H6R UPF0380 protein HVW38_RS16970 ENOG4105MFG Antirestriction protein HVW38_RS16975 ENOG4108YGG dna repair protein HVW38_RS16985 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVW38_RS17025 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVW38_RS17030 ENOG410765S (LipO)protein HVW38_RS17045 ENOG4107QHF type ii secretion system protein e HVW38_RS17050 ENOG4105D7Q type ii secretion system HVW38_RS17055 ENOG4108VAU general secretion pathway protein G HVW38_RS17065 ENOG4105X5Z General secretion pathway protein I HVW38_RS17085 ENOG4105U1E general secretion pathway protein M HVW38_RS17090 ENOG410600K aminopeptidase HVW38_RS17095 ENOG4106032 Glutathionylspermidine synthase HVW38_RS17105 ENOG4105CYM Glutathione S-transferase HVW38_RS17110 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVW38_RS17120 ENOG4108WGS hydrogenase 2-specific chaperone HVW38_RS17125 ENOG4108USZ hydrogenase HVW38_RS17130 ENOG4105DPX Hydrogenase, large subunit HVW38_RS17135 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVW38_RS17140 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVW38_RS17145 ENOG4105E3S small subunit HVW38_RS17150 ENOG410900S Protein of unknown function (DUF2623) HVW38_RS17160 ENOG4105CPC Aldo Keto reductase HVW38_RS17170 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVW38_RS17175 ENOG4108ZZF transport protein (ExbD) HVW38_RS17180 ENOG4105CWK Biopolymer transport protein, ExbB HVW38_RS17185 ENOG4105C28 cystathionine HVW38_RS17190 ENOG4108K81 inner membrane protein YghB HVW38_RS17195 ENOG4105CF7 AraC family transcriptional regulator HVW38_RS17200 ENOG4108I6A alcohol dehydrogenase HVW38_RS17205 ENOG4105CV8 reductase HVW38_RS17210 ENOG4107QPK )-transporter HVW38_RS17220 ENOG4105CCT upf0313 protein HVW38_RS17225 ENOG4107YCY Transcriptional regulator HVW38_RS17230 ENOG4105DEI Mannitol dehydrogenase HVW38_RS17235 ENOG4105CPQ Dehydrogenase HVW38_RS17240 ENOG4105DG4 malate L-lactate dehydrogenase HVW38_RS17245 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVW38_RS17255 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVW38_RS17260 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVW38_RS17265 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVW38_RS17270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVW38_RS17275 ENOG4105H4F exported protein HVW38_RS17280 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVW38_RS17285 ENOG4105DHQ Histidine kinase HVW38_RS17290 ENOG4105NF4 modulator of drug activity HVW38_RS17295 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVW38_RS17300 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVW38_RS17305 ENOG4105IPS esterase HVW38_RS17310 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVW38_RS17315 ENOG4108SX3 cytoplasmic protein HVW38_RS17320 ENOG41087AY ADP-Ribose pyrophosphatase HVW38_RS17325 ENOG4105DFG type I secretion outer membrane protein HVW38_RS17335 ENOG4106032 Glutathionylspermidine synthase HVW38_RS17340 ENOG4108MR7 Arylsulfotransferase HVW38_RS17345 ENOG4108N92 Thiol disulfide Interchange Protein HVW38_RS17355 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVW38_RS17370 ENOG4105H8W Fimbrial protein HVW38_RS17380 ENOG4108TTM chaperone HVW38_RS17385 ENOG4108MY7 Fimbrial HVW38_RS17395 ENOG4105W0Z cytoplasmic protein HVW38_RS17405 ENOG4105PV3 Inner membrane protein yqiJ HVW38_RS17410 ENOG4107S78 Band 7 protein HVW38_RS17440 ENOG4105I7R Adenylate cyclase HVW38_RS17445 ENOG4106MWK domain protein HVW38_RS17460 ENOG4107ZVW dihydroneopterin aldolase HVW38_RS17470 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVW38_RS17480 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVW38_RS17485 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVW38_RS17505 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVW38_RS17545 ENOG41080XV Thioredoxin HVW38_RS17555 ENOG4105Q26 Siderophore-interacting protein HVW38_RS17560 ENOG4105NTW Transcriptional regulator HVW38_RS17565 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVW38_RS17575 ENOG4105CBP Major Facilitator HVW38_RS17585 ENOG4105C6F GntR Family Transcriptional Regulator HVW38_RS17590 ENOG4105DEI Mannitol dehydrogenase HVW38_RS17600 ENOG4105Y4Z Outer Membrane Lipoprotein HVW38_RS17610 ENOG4105KT7 mgtC SapB transporter HVW38_RS17615 ENOG4105XXV Acid-resistance protein HVW38_RS17620 ENOG41060V2 Acid-resistance protein HVW38_RS17625 ENOG4108YK4 Acid-resistance membrane protein HVW38_RS17630 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVW38_RS17635 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVW38_RS17640 ENOG4105BZS acriflavin resistance protein HVW38_RS17650 ENOG4108NKV transcriptional regulator HVW38_RS17655 ENOG4105D6F Phosphatase HVW38_RS17665 ENOG4106D80 Uncharacterized protein YhaL HVW38_RS17680 ENOG4105C7B Threonine dehydratase HVW38_RS17685 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVW38_RS17690 ENOG4105CIZ coA-substrate-specific enzyme activase HVW38_RS17700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVW38_RS17705 ENOG4105C8Q Methyl-accepting chemotaxis HVW38_RS17715 ENOG4108IA2 Sodium pantothenate symporter HVW38_RS17735 ENOG4108V8F Transcriptional regulator, MarR family HVW38_RS17740 ENOG4105ERH Fumarylacetoacetate hydrolase HVW38_RS17745 ENOG4105C26 Dehydrogenase HVW38_RS17750 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVW38_RS17780 ENOG4105EFA 4-hydroxyphenylacetate HVW38_RS17785 ENOG4107UWN reductase HVW38_RS17790 ENOG4105D22 carbon starvation protein HVW38_RS17795 ENOG4105VCD cytoplasmic protein HVW38_RS17800 ENOG4105CKI cobalamin synthesis protein HVW38_RS17820 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HVW38_RS17825 ENOG4105CVR type I restriction-modification system HVW38_RS17830 ENOG4107XZC Restriction modification system DNA (Specificity HVW38_RS17840 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HVW38_RS17845 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC HVW38_RS17855 ENOG4108YUH HVW38_RS17860 ENOG4106DIZ Domain of unknown function (DUF1127) HVW38_RS17865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVW38_RS17875 ENOG41083G8 Multidrug resistance protein MdtM HVW38_RS17880 ENOG4106BRA Membrane HVW38_RS17910 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HVW38_RS17940 ENOG4105DQ4 alcohol dehydrogenase HVW38_RS17945 ENOG4105D7A ATP-binding protein HVW38_RS17950 ENOG4107S21 permease HVW38_RS17955 ENOG4105K4T epimerase HVW38_RS17960 ENOG4107R7Y intracellular protease Pfpi family HVW38_RS17975 ENOG4108YYD acetyltransferase HVW38_RS17995 ENOG4105DEN Luciferase family HVW38_RS18000 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVW38_RS18045 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HVW38_RS18065 ENOG4108K70 Transcriptional regulator HVW38_RS18070 ENOG4105CIC tryptophan-specific transport protein HVW38_RS18075 ENOG4105C1J atp-dependent rna helicase HVW38_RS18115 ENOG4105CHV Transcription elongation factor NusA HVW38_RS18135 ENOG4105DIJ Phosphoethanolamine transferase HVW38_RS18145 ENOG4105NTZ Preprotein translocase subunit SecG HVW38_RS18155 ENOG4105EEI dihydropteroate synthase HVW38_RS18160 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVW38_RS18170 ENOG4105HBR Rna-binding protein HVW38_RS18175 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVW38_RS18180 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVW38_RS18190 ENOG4105QYV Membrane HVW38_RS18205 ENOG4105EAH synthase HVW38_RS18210 ENOG4105HVQ Regulatory factor of maltose metabolism HVW38_RS18220 ENOG4105VFK BolA family HVW38_RS18225 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVW38_RS18230 ENOG4105E3I toluene tolerance HVW38_RS18235 ENOG4107PE3 Mammalian cell entry related domain protein HVW38_RS18240 ENOG4105CY3 ABC transporter, permease HVW38_RS18245 ENOG4105DHJ ABC, transporter HVW38_RS18250 ENOG4105FEU K -dependent Na -Ca exchanger HVW38_RS18255 ENOG4105C2X Arabinose 5-phosphate isomerase HVW38_RS18265 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVW38_RS18270 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVW38_RS18275 ENOG4108IUZ ABC transporter HVW38_RS18280 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVW38_RS18285 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVW38_RS18290 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVW38_RS18300 ENOG41080Z8 PHOSPHOCARRIER protein HVW38_RS18305 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVW38_RS18315 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVW38_RS18320 ENOG4105BZU Histidine kinase HVW38_RS18325 ENOG4105N5T Radical SAM Protein HVW38_RS18330 ENOG4105CBC glutamate synthase HVW38_RS18335 ENOG4105BZ8 glutamate synthase HVW38_RS18340 ENOG4105DFS Conserved Protein HVW38_RS18345 ENOG4108R66 Conserved Protein HVW38_RS18375 ENOG4105KB2 stringent starvation protein b HVW38_RS18380 ENOG4107MKT Stringent starvation protein a HVW38_RS18395 ENOG4105D6Z AFG1 family ATPase HVW38_RS18400 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVW38_RS18405 ENOG4105C0H protease HVW38_RS18410 ENOG4105C0H protease HVW38_RS18420 ENOG4107GFK fumarate HVW38_RS18425 ENOG4106DSS Tartrate dehydratase subunit alpha HVW38_RS18430 ENOG4105C8P )-transporter HVW38_RS18440 ENOG4105G3Z GntR family transcriptional regulator HVW38_RS18455 ENOG4105RID UPF0379 protein yhcN HVW38_RS18460 ENOG4107ENK receptor HVW38_RS18465 ENOG4105UNR (Barnase) inhibitor HVW38_RS18480 ENOG4105ZQC membrane protein AaeX HVW38_RS18485 ENOG4105CR8 Transcriptional regulator HVW38_RS18490 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVW38_RS18495 ENOG4105QD6 exported protein HVW38_RS18500 ENOG4105C03 ribonuclease HVW38_RS18510 ENOG4105VQ7 Rod shape-determining protein MreD HVW38_RS18515 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVW38_RS18525 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVW38_RS18530 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVW38_RS18545 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVW38_RS18550 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVW38_RS18555 ENOG4105RG0 Membrane HVW38_RS18560 ENOG4108IA2 Sodium pantothenate symporter HVW38_RS18570 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVW38_RS18580 ENOG4105CEC DNA methylase N-4 N-6 HVW38_RS18585 ENOG41061ME transport protein HVW38_RS18590 ENOG4108XG4 DNA-binding transcriptional regulator HVW38_RS18595 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVW38_RS18600 ENOG4105BZS acriflavin resistance protein HVW38_RS18605 ENOG4105XCM membrane LIPOPROTEIN HVW38_RS18615 ENOG4105EZ7 amino acid ABC transporter HVW38_RS18620 ENOG4105DRP amino acid AbC transporter HVW38_RS18625 ENOG4105CDA abc transporter atp-binding protein HVW38_RS18665 ENOG4108Z0R Transferase HVW38_RS18670 ENOG4105SG3 Protein of unknown function (DUF1488) HVW38_RS18685 ENOG4108WI1 Dna topoisomerase HVW38_RS18695 ENOG4105C79 DNA protecting protein DprA HVW38_RS18715 ENOG4105C1A potassium transporter peripheral membrane HVW38_RS18725 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVW38_RS18730 ENOG4105W1Y Transcriptional regulator HVW38_RS18735 ENOG4105VTS DnaJ-like, subfamily C HVW38_RS18765 ENOG41067V7 50S ribosomal protein L36 HVW38_RS18770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVW38_RS18815 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVW38_RS18860 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVW38_RS18885 ENOG4108UQY Iron-storage protein HVW38_RS18890 ENOG4105W53 bacterioferritin-associated ferredoxin HVW38_RS18920 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVW38_RS18930 ENOG4105WWK YheO domain protein HVW38_RS18935 ENOG4108V1T peptidylprolyl cis-trans isomerase HVW38_RS18950 ENOG4105VKU nucleicacid-binding protein HVW38_RS18965 ENOG4105C5H ABC transporter HVW38_RS18970 ENOG4105DNZ Alpha Beta Hydrolase HVW38_RS18980 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVW38_RS18985 ENOG4108UKZ OsmC family HVW38_RS18995 ENOG410613R integral membrane protein, YccS YhfK family HVW38_RS19000 ENOG4105C8Y Acetylornithine aminotransferase HVW38_RS19005 ENOG4105DDQ anthranilate synthase HVW38_RS19010 ENOG4105MZU cell filamentation protein HVW38_RS19020 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVW38_RS19025 ENOG4107QZF nitrite reductase NADPH large subunit HVW38_RS19030 ENOG4105WZK nitrite reductase NADPH small subunit HVW38_RS19035 ENOG4107V9H nitrite transporter HVW38_RS19045 ENOG4105VYH HVW38_RS19050 ENOG4106PKC pyridoxal phosphate binding HVW38_RS19055 ENOG4106M0N transport system permease protein HVW38_RS19060 ENOG4105MUZ Protein of unknown function DUF2620 HVW38_RS19065 ENOG41080QX K07048 phosphotriesterase-related protein HVW38_RS19070 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVW38_RS19075 ENOG4108626 Racemase HVW38_RS19080 ENOG4105RMW regulation of transcription, DNA-dependent HVW38_RS19085 ENOG4108M21 HVW38_RS19090 ENOG4105C31 Tryptophanyl-tRNA synthetase HVW38_RS19095 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVW38_RS19100 ENOG4105DJV ribulose-phosphate 3-epimerase HVW38_RS19105 ENOG4105DFE Dna adenine methylase HVW38_RS19110 ENOG4105EGB membrane protein DamX HVW38_RS19125 ENOG4105E4G Type IV pilus HVW38_RS19130 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVW38_RS19135 ENOG4105XPX DNA utilization protein HofO HVW38_RS19140 ENOG41065NF Fimbrial assembly family protein HVW38_RS19145 ENOG4108U1Q Pilus assembly protein HVW38_RS19150 ENOG4108JQC penicillin-binding protein 1A HVW38_RS19155 ENOG4107RK2 ADP-ribose diphosphatase NudE HVW38_RS19160 ENOG4105DQY intracellular growth attenuator HVW38_RS19165 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVW38_RS19170 ENOG4105VEJ Heat shock protein HVW38_RS19180 ENOG4108MAJ Membrane HVW38_RS19215 ENOG4105E0F Histidine kinase HVW38_RS19225 ENOG4108RRZ Transcription elongation factor GreB HVW38_RS19230 ENOG4105BZM domain protein HVW38_RS19235 ENOG4105XFK Ferrous iron transport protein A HVW38_RS19240 ENOG4105CE1 Ferrous iron transport protein b HVW38_RS19250 ENOG4105DNE Transposase HVW38_RS19260 ENOG4105MJ2 Competence protein HVW38_RS19270 ENOG4105C6Z Gluconate HVW38_RS19280 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVW38_RS19285 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVW38_RS19295 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HVW38_RS19300 ENOG4105E0Y RtcB Protein HVW38_RS19305 ENOG4105CYB regulatoR HVW38_RS19310 ENOG4105E98 transcriptional regulator DeoR family HVW38_RS19325 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVW38_RS19345 ENOG4105MHR Fimbrial protein HVW38_RS19350 ENOG4106PH7 chaperone HVW38_RS19360 ENOG4108WDE Fimbrial protein HVW38_RS19370 ENOG4108NAE Fimbrial chaperone protein HVW38_RS19380 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVW38_RS19405 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVW38_RS19410 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVW38_RS19415 ENOG4105C6Z Gluconate HVW38_RS19420 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVW38_RS19425 ENOG4105DIQ Transcriptional regulator HVW38_RS19430 ENOG4105C2I pirin domain protein HVW38_RS19435 ENOG4105D9R oxidoreductase HVW38_RS19440 ENOG4105WCN acetyltransferase HVW38_RS19445 ENOG4106FA4 HVW38_RS19450 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVW38_RS19455 ENOG4105WC8 Conserved Protein HVW38_RS19460 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVW38_RS19470 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVW38_RS19475 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVW38_RS19480 ENOG4105BZ7 extracellular solute-binding protein family 1 HVW38_RS19490 ENOG4108IV0 ABC, transporter HVW38_RS19495 ENOG4105C0Z ABC transporter HVW38_RS19500 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVW38_RS19505 ENOG4105C32 Amino acid ABC transporter (Permease) HVW38_RS19510 ENOG4105CP9 extracellular ligand-binding receptor HVW38_RS19515 ENOG4105U59 -acetyltransferase HVW38_RS19520 ENOG4105CP9 extracellular ligand-binding receptor HVW38_RS19525 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVW38_RS19530 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVW38_RS19535 ENOG4105CAK Cell division ATP-binding protein ftsE HVW38_RS19540 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVW38_RS19545 ENOG4106H78 methyltransferase HVW38_RS19550 ENOG4105MG3 Membrane HVW38_RS19560 ENOG4107FS9 Membrane HVW38_RS19575 ENOG4105EX9 Membrane HVW38_RS19580 ENOG4108W1V Lipoprotein HVW38_RS19590 ENOG4105DSF transport protein HVW38_RS19610 ENOG4105E9Q Acyl-transferase HVW38_RS19640 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HVW38_RS19665 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVW38_RS19675 ENOG4105C2D reductase HVW38_RS19680 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVW38_RS19685 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVW38_RS19695 ENOG4105CMI transporter HVW38_RS19700 ENOG4105CJ1 ABC, transporter HVW38_RS19705 ENOG4105D0S secretion protein (HlyD HVW38_RS19710 ENOG4107UNS conserved inner membrane protein HVW38_RS19735 ENOG4105CBX hi0933 family HVW38_RS19740 ENOG4105CJ3 phosphate transporter HVW38_RS19755 ENOG4105DUX Transporter HVW38_RS19770 ENOG4105F38 ABC transporter, permease HVW38_RS19785 ENOG4105E2R ROK family HVW38_RS19795 ENOG4105DGW oligopeptidase A HVW38_RS19800 ENOG4105D6S protein involved in catabolism of external DNA HVW38_RS19805 ENOG4105DC8 reductase HVW38_RS19820 ENOG4105KBH arsR family transcriptional regulator HVW38_RS19825 ENOG4107R5R arsenical pump membrane protein HVW38_RS19830 ENOG4105K89 arsenate reductase HVW38_RS19850 ENOG4106S2D Transcriptional regulator HVW38_RS19855 ENOG4107H3J ribonuclease HVW38_RS19860 ENOG4105CSH Transporter HVW38_RS19865 ENOG41066T0 asmA family HVW38_RS19870 ENOG4105CMB EAL domain-containing protein HVW38_RS19875 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVW38_RS19890 ENOG4105CS0 peptidase HVW38_RS19900 ENOG4105BZU Histidine kinase HVW38_RS19905 ENOG4105EJG cellulose synthase HVW38_RS19910 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVW38_RS19915 ENOG4107EEX Cellulose synthase regulator protein HVW38_RS19920 ENOG4107QZ7 Cellulose synthase catalytic subunit HVW38_RS19930 ENOG410661M cytoplasmic protein HVW38_RS19935 ENOG4105U74 cellulose biosynthesis protein BcsE HVW38_RS19940 ENOG4105WQA Cellulose biosynthesis protein BcsF HVW38_RS19945 ENOG4105D1V cellulose synthase operon protein YhjU HVW38_RS19965 ENOG4105C28 cystathionine HVW38_RS19970 ENOG4105C44 Serine transporter HVW38_RS19980 ENOG4108JQ7 (ABC) transporter HVW38_RS19985 ENOG4105C3U ABC transporter HVW38_RS19990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVW38_RS19995 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVW38_RS20000 ENOG4105DEF Extracellular solute-binding protein, family 5 HVW38_RS20015 ENOG4105DIJ Phosphoethanolamine transferase HVW38_RS20020 ENOG4105FCD Major Facilitator HVW38_RS20025 ENOG4105EAX Putative lipase HVW38_RS20030 ENOG4108R3E Dna-3-methyladenine glycosylase i HVW38_RS20035 ENOG4105HNP -acetyltransferase HVW38_RS20040 ENOG4107QY8 reductase HVW38_RS20045 ENOG4108ZG0 Ompa motb domain protein HVW38_RS20050 ENOG4108M60 Transcriptional regulator HVW38_RS20060 ENOG4105D7K pfkb domain protein HVW38_RS20075 ENOG4106JH6 (LipO)protein HVW38_RS20080 ENOG4105D2S major facilitator superfamily HVW38_RS20085 ENOG4105MVF Transcriptional regulator HVW38_RS20120 ENOG4105MEV Acyl-transferase HVW38_RS20125 ENOG410688U Inner membrane protein yiaB HVW38_RS20130 ENOG4105CMG Carbohydrate kinase HVW38_RS20140 ENOG4105T16 Transcriptional regulator (AraC family) HVW38_RS20145 ENOG4108UR8 BAX protein HVW38_RS20150 ENOG4107T9C Alpha amylase catalytic region HVW38_RS20155 ENOG4105JKW Valine--pyruvate aminotransferase HVW38_RS20160 ENOG4108XIB electron transport protein ysaA HVW38_RS20165 ENOG4105J4Q Transcriptional regulator HVW38_RS20175 ENOG4108R66 Conserved Protein HVW38_RS20180 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVW38_RS20185 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVW38_RS20190 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVW38_RS20195 ENOG4105CMG Carbohydrate kinase HVW38_RS20200 ENOG4105H6Q decarboxylase HVW38_RS20205 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVW38_RS20210 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVW38_RS20215 ENOG4105C26 Dehydrogenase HVW38_RS20220 ENOG4105C0A alcohol dehydrogenase HVW38_RS20225 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVW38_RS20235 ENOG4108U78 Glutathione S-transferase HVW38_RS20240 ENOG4105EFX secretion protein, HlyD family HVW38_RS20245 ENOG4105FP6 Protein of unknown function (DUF3302) HVW38_RS20250 ENOG4105CTS PTS system mannitol-specific HVW38_RS20260 ENOG4105E61 Mannitol repressor protein HVW38_RS20270 ENOG4108YYI Protein of unknown function (DUF2810) HVW38_RS20290 ENOG4105EUR Domain-Containing protein HVW38_RS20295 ENOG4105DAA L-lactate HVW38_RS20300 ENOG41073TP transcriptional regulator HVW38_RS20310 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVW38_RS20315 ENOG4105D7W serine acetyltransferase HVW38_RS20330 ENOG4105VW4 glutaredoxin 3 HVW38_RS20335 ENOG4107YZP Rhodanese domain protein HVW38_RS20345 ENOG41063SB peptidase HVW38_RS20350 ENOG4105PXI polysaccharide deacetylase HVW38_RS20355 ENOG4105K64 Glycosyl transferase, family 2 HVW38_RS20360 ENOG4105D4P Coproporphyrinogen iii oxidase HVW38_RS20365 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVW38_RS20380 ENOG4105C2M dna polymerase I HVW38_RS20385 ENOG4106HNH Acyl-transferase HVW38_RS20395 ENOG4108Z33 Thiol disulfide Interchange Protein HVW38_RS20400 ENOG4105E27 serine threonine protein kinase HVW38_RS20405 ENOG4105PC1 Conserved Protein HVW38_RS20410 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVW38_RS20415 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVW38_RS20445 ENOG4108RR8 protoporphyrinogen oxidase HVW38_RS20450 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVW38_RS20455 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVW38_RS20475 ENOG4108MR7 Arylsulfotransferase HVW38_RS20480 ENOG4108EX3 reductase HVW38_RS20485 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVW38_RS20490 ENOG4105MDZ Transcriptional activator rfaH HVW38_RS20500 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVW38_RS20505 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVW38_RS20510 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVW38_RS20520 ENOG4105JC1 sterol-binding domain protein HVW38_RS20530 ENOG4105CGY Dna recombination protein HVW38_RS20535 ENOG4107HP6 Transcriptional regulator HVW38_RS20540 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVW38_RS20545 ENOG4108RTU Aldolase HVW38_RS20550 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVW38_RS20565 ENOG4108I5U Uridine phosphorylase HVW38_RS20570 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVW38_RS20595 ENOG4105F04 LysR family Transcriptional regulator HVW38_RS20610 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HVW38_RS20615 ENOG4105C7F AcnD-accessory protein PrpF HVW38_RS20620 ENOG4107QM5 aconitate hydratase HVW38_RS20625 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVW38_RS20645 ENOG4105DZ2 Transcriptional regulator HVW38_RS20650 ENOG4105EMK carboxylate amino acid amine transporter HVW38_RS20655 ENOG4105DQF Hydrolase HVW38_RS20660 ENOG4108EUD Lysophospholipase HVW38_RS20665 ENOG410829K Lysine exporter protein (Lyse ygga) HVW38_RS20675 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVW38_RS20680 ENOG4105C9U ATP-dependent DNA helicase RecQ HVW38_RS20690 ENOG4105HDD phospholipase HVW38_RS20695 ENOG4108VUY thioesterase Superfamily protein HVW38_RS20700 ENOG4105FR1 rard protein HVW38_RS20705 ENOG4107QUT magnesium and cobalt transport protein CorA HVW38_RS20710 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVW38_RS20715 ENOG4105C4R Atp-dependent dna helicase HVW38_RS20720 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVW38_RS20730 ENOG4105CT0 Protein of unknown function, DUF484 HVW38_RS20740 ENOG4105S7Z (LipO)protein HVW38_RS20755 ENOG4107T0K Adenylate cyclase HVW38_RS20765 ENOG41076E6 Uroporphyrinogen-III Synthase HVW38_RS20770 ENOG4105ECF c-methyltransferase HVW38_RS20775 ENOG410601J HemY protein HVW38_RS20780 ENOG4105ENH Sulfatase HVW38_RS20785 ENOG4105C4X radical SAM domain protein HVW38_RS20810 ENOG4105C85 amino acid HVW38_RS20825 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HVW38_RS20830 ENOG4105EGZ biosynthesis protein HVW38_RS20835 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVW38_RS20840 ENOG4108WJ1 acetyltransferase HVW38_RS20845 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVW38_RS20850 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVW38_RS20855 ENOG4107QQG Dehydrogenase HVW38_RS20860 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVW38_RS20865 ENOG4105SFE lipopolysaccharide biosynthesis protein HVW38_RS20870 ENOG4105ESV Glycosyl transferase, family 4 HVW38_RS20875 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVW38_RS20900 ENOG4105C4R Atp-dependent dna helicase HVW38_RS20905 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVW38_RS20915 ENOG4105EMY transcriptional regulator HVW38_RS20920 ENOG4105C7B Threonine dehydratase HVW38_RS20930 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVW38_RS20935 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVW38_RS20955 ENOG4105C0P Mg chelatase subunit ChlI HVW38_RS20960 ENOG4108WFC UPF0438 protein yifE HVW38_RS21000 ENOG4107EJG GntR family transcriptional regulator HVW38_RS21005 ENOG4105ETE Transcriptional regulator (LacI family HVW38_RS21010 ENOG4108RVA ribokinase HVW38_RS21015 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVW38_RS21020 ENOG4105CNN ABC, transporter HVW38_RS21025 ENOG4105C2J ABC transporter HVW38_RS21055 ENOG4108VVK transcriptional Regulator, AsnC HVW38_RS21060 ENOG4105QTB Flavodoxin HVW38_RS21075 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVW38_RS21130 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVW38_RS21135 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVW38_RS21140 ENOG4105C8U phosphate abc transporter HVW38_RS21145 ENOG4105E2Z phosphate ABC transporter (Permease HVW38_RS21150 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVW38_RS21155 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVW38_RS21160 ENOG4105CID antiterminator HVW38_RS21165 ENOG4105C5Y PTS System HVW38_RS21170 ENOG4105CS2 ec 3.2.1.21 HVW38_RS21180 ENOG4105DYC esterase HVW38_RS21190 ENOG4106611 bacteriocin immunity HVW38_RS21200 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVW38_RS21205 ENOG4105C7N Xanthine uracil vitamin C permease HVW38_RS21215 ENOG4108YYH Nadph-dependent fmn reductase HVW38_RS21220 ENOG4105E8Q phosphopantetheinyl transferase HVW38_RS21235 ENOG4108P6C Tryptophan transporter of low affinity HVW38_RS21270 ENOG4105VG0 50S ribosomal protein l34 HVW38_RS21285 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVW38_RS21295 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVW38_RS21300 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVW38_RS21305 ENOG410667J hydrolase HVW38_RS21310 ENOG410657R replicase EC 2.7 HVW38_RS21315 ENOG4105EMF GntR family transcriptional regulator HVW38_RS21320 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVW38_RS21325 ENOG4108RTU Aldolase HVW38_RS21335 ENOG4105DJB Major Facilitator Superfamily HVW38_RS21345 ENOG4105D99 atp gtp-binding protein HVW38_RS21350 ENOG4105R2A (LipO)protein HVW38_RS21360 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HVW38_RS21365 ENOG4105D0C transport protein HVW38_RS21370 ENOG4105FDP GntR family transcriptional regulator HVW38_RS21375 ENOG4105CI1 PTS System HVW38_RS21380 ENOG4105F8D glycoside hydrolase family 4 HVW38_RS21390 ENOG4105VG5 Membrane HVW38_RS21395 ENOG4105JP4 Inner membrane protein yidG HVW38_RS21400 ENOG4105J13 transcriptional regulator HVW38_RS21415 ENOG4105W8I Transcriptional regulator HVW38_RS21420 ENOG4105E5M Multidrug resistance protein D HVW38_RS21435 ENOG4105C7K acetolactate synthase HVW38_RS21440 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVW38_RS21445 ENOG4108KX4 response regulator HVW38_RS21455 ENOG4105CXY transporter HVW38_RS21460 ENOG4105CXY transporter HVW38_RS21470 ENOG4108SAJ Protein of unknown function (DUF1198) HVW38_RS21480 ENOG4105VCP PTS System HVW38_RS21485 ENOG4105CS2 ec 3.2.1.21 HVW38_RS21490 ENOG4105CK1 PTS System HVW38_RS21500 ENOG4105ETE Transcriptional regulator (LacI family HVW38_RS21505 ENOG4105T8A Uncharacterized protein YicS HVW38_RS21510 ENOG4108UZ3 Transporter HVW38_RS21530 ENOG4105CT4 transporter HVW38_RS21535 ENOG4105CJQ hydrolase, family 31 HVW38_RS21540 ENOG4105JV1 AsmA family HVW38_RS21545 ENOG4105C2W permease HVW38_RS21550 ENOG4105D6U Sodium Glutamate Symporter HVW38_RS21560 ENOG4105CB5 ATP-dependent DNA helicase recG HVW38_RS21565 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVW38_RS21570 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVW38_RS21580 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVW38_RS21590 ENOG4105EN6 Membrane HVW38_RS21595 ENOG4105DSJ YicC domain protein HVW38_RS21610 ENOG4107RRE RNA-directed DNA polymerase HVW38_RS21620 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVW38_RS21625 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVW38_RS21635 ENOG4105KDC 50s ribosomal protein l28 HVW38_RS21655 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVW38_RS21660 ENOG4105DKP glycosyl transferase, family 9 HVW38_RS21665 ENOG4107RJ7 Glycosyl transferase (Group 1 HVW38_RS21670 ENOG4107543 (lipo)polysaccharide HVW38_RS21675 ENOG410650X lipopolysaccharide core region biosynthetic process HVW38_RS21680 ENOG4107XU6 Glycosyl transferase (Group 1 HVW38_RS21685 ENOG4106AH0 Glycosyl Transferase HVW38_RS21690 ENOG4105X1N Glycosyl transferase family 8 HVW38_RS21695 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVW38_RS21700 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVW38_RS21705 ENOG4108XNZ glycosyl transferase HVW38_RS21710 ENOG41068PG O-Antigen polymerase HVW38_RS21715 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVW38_RS21720 ENOG4105XA0 heptosyltransferase ii HVW38_RS21730 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVW38_RS21740 ENOG4106FIY HVW38_RS21745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVW38_RS21750 ENOG4105CUX Signal transduction histidine kinase HVW38_RS21755 ENOG4105C5F glutamine synthetase HVW38_RS21760 ENOG4105CI3 gtp-binding protein typa HVW38_RS21765 ENOG4108K4B hydrolase HVW38_RS21775 ENOG4105CSA Coproporphyrinogen iii oxidase HVW38_RS21795 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVW38_RS21810 ENOG4105SUU thioesterase domain HVW38_RS21845 ENOG4108MG3 formate dehydrogenase HVW38_RS21850 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVW38_RS21865 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HVW38_RS21875 ENOG4108V87 frv operon regulatory protein HVW38_RS21885 ENOG4106C3V frv operon regulatory protein HVW38_RS21890 ENOG4105CN9 Peptidase m42 family protein HVW38_RS21900 ENOG41064BA PTS system, fructose-specific, IIA component HVW38_RS21910 ENOG4105C0A alcohol dehydrogenase HVW38_RS21945 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVW38_RS21950 ENOG4108RPX mosc domain containing protein HVW38_RS21955 ENOG4105E0F Histidine kinase HVW38_RS21960 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVW38_RS21965 ENOG4105FMW periplasmic HVW38_RS21970 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVW38_RS22030 ENOG4105E5H Transposase HVW38_RS22035 ENOG4108YXQ IS66 Orf2 family protein HVW38_RS22050 ENOG4105F5W AtP-binding protein HVW38_RS22055 ENOG4105D70 Integrase catalytic subunit HVW38_RS22120 ENOG4105D5G Transposase HVW38_RS22135 ENOG4108YXQ IS66 Orf2 family protein HVW38_RS22140 ENOG4105E5H Transposase HVW38_RS22200 ENOG4105ZEG Suppressor protein HVW38_RS22210 ENOG4105DB4 HVW38_RS22300 ENOG41073YN Protein of unknown function (DUF1380) HVW38_RS22340 ENOG4105FEQ ParB domain protein nuclease HVW38_RS22440 ENOG4105KF5 hemolysin expression-modulating protein HVW38_RS22535 ENOG4105CZX twitching motility protein HVW38_RS22580 ENOG4105K5T PilT protein HVW38_RS22595 ENOG4107QHF type ii secretion system protein e