locus-tag	class	description
HVW38_RS00020	COG1484	DNA-dependent DNA replication
HVW38_RS00025	COG4584	PFAM Integrase catalytic
HVW38_RS00120	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVW38_RS00125	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVW38_RS00185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVW38_RS00205	COG3152	Membrane
HVW38_RS00210	COG3691	Protein conserved in bacteria
HVW38_RS00215	COG0589	response to stress
HVW38_RS00225	COG1494	fructose-1,6-bisphosphatase
HVW38_RS00235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVW38_RS00250	COG1575	Belongs to the MenA family. Type 1 subfamily
HVW38_RS00265	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVW38_RS00270	COG1609	Transcriptional regulator
HVW38_RS00275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVW38_RS00290	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVW38_RS00300	COG0626	cystathionine gamma-synthase activity
HVW38_RS00305	COG0460	homoserine dehydrogenase
HVW38_RS00305	COG0527	aspartate kinase activity
HVW38_RS00315	COG0737	Belongs to the 5'-nucleotidase family
HVW38_RS00325	COG0583	DNA-binding transcription factor activity
HVW38_RS00330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HVW38_RS00335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVW38_RS00355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVW38_RS00365	COG0697	spore germination
HVW38_RS00370	COG3738	Protein conserved in bacteria
HVW38_RS00375	COG0371	Dehydrogenase
HVW38_RS00380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVW38_RS00385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS00385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS00385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVW38_RS00390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS00395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS00400	COG1882	Formate acetyltransferase
HVW38_RS00405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW38_RS00410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS00415	COG2207	Transcriptional regulator
HVW38_RS00420	COG2194	sulfuric ester hydrolase activity
HVW38_RS00435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVW38_RS00450	COG0583	DNA-binding transcription factor activity
HVW38_RS00460	COG1473	amidohydrolase
HVW38_RS00465	COG0477	Major facilitator Superfamily
HVW38_RS00470	COG1309	transcriptional regulator
HVW38_RS00515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVW38_RS00520	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVW38_RS00520	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVW38_RS00555	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVW38_RS00560	COG0250	Participates in transcription elongation, termination and antitermination
HVW38_RS00595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVW38_RS00605	COG2104	thiamine diphosphate biosynthetic process
HVW38_RS00610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVW38_RS00645	COG3068	Protein conserved in bacteria
HVW38_RS00660	COG3678	ATP-independent chaperone mediated protein folding
HVW38_RS00665	COG4191	Histidine kinase
HVW38_RS00670	COG2204	response regulator
HVW38_RS00675	COG0151	Belongs to the GarS family
HVW38_RS00705	COG0456	acetyltransferase
HVW38_RS00715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVW38_RS00720	COG2224	Isocitrate lyase
HVW38_RS00735	COG1414	Transcriptional regulator
HVW38_RS00740	COG0646	methionine synthase
HVW38_RS00740	COG1410	methionine synthase
HVW38_RS00755	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVW38_RS00760	COG3122	Protein conserved in bacteria
HVW38_RS00805	COG1187	pseudouridine synthase activity
HVW38_RS00850	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVW38_RS00930	COG0741	lytic transglycosylase activity
HVW38_RS00945	COG0542	response to heat
HVW38_RS00950	COG0527	aspartate kinase activity
HVW38_RS00975	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW38_RS00990	COG0477	Major facilitator Superfamily
HVW38_RS00990	COG2814	Major facilitator Superfamily
HVW38_RS00995	COG3833	ABC-type maltose transport systems, permease component
HVW38_RS01000	COG1175	transmembrane transport
HVW38_RS01005	COG2182	Extracellular solute-binding protein
HVW38_RS01010	COG3842	ATPase activity
HVW38_RS01045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVW38_RS01055	COG0534	Mate efflux family protein
HVW38_RS01060	COG3237	CsbD-like
HVW38_RS01065	COG0735	belongs to the Fur family
HVW38_RS01070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVW38_RS01080	COG0604	alcohol dehydrogenase
HVW38_RS01085	COG0305	Participates in initiation and elongation during chromosome replication
HVW38_RS01095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVW38_RS01110	COG1448	Aminotransferase
HVW38_RS01115	COG0567	Dehydrogenase, E1 component
HVW38_RS01125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVW38_RS01130	COG0045	succinate-CoA ligase (ADP-forming) activity
HVW38_RS01135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVW38_RS01140	COG0471	metal ion transport
HVW38_RS01145	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVW38_RS01150	COG2204	response regulator
HVW38_RS01160	COG3700	Belongs to the class B bacterial acid phosphatase family
HVW38_RS01165	COG0432	Pfam Uncharacterised protein family UPF0047
HVW38_RS01170	COG2315	Protein conserved in bacteria
HVW38_RS01175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVW38_RS01180	COG0629	single-stranded DNA binding
HVW38_RS01195	COG0789	Transcriptional regulator
HVW38_RS01200	COG2252	PERMEase
HVW38_RS01205	COG0025	NhaP-type Na H and K H
HVW38_RS01210	COG2824	Alkylphosphonate utilization operon protein PhnA
HVW38_RS01215	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVW38_RS01230	COG0642	Histidine kinase
HVW38_RS01235	COG0745	RESPONSE REGULATOR receiver
HVW38_RS01240	COG2194	sulfuric ester hydrolase activity
HVW38_RS01245	COG2207	Transcriptional regulator
HVW38_RS01250	COG3647	Membrane
HVW38_RS01255	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW38_RS01255	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW38_RS01260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVW38_RS01265	COG4565	transcriptional regulatory protein
HVW38_RS01270	COG3290	protein histidine kinase activity
HVW38_RS01275	COG0243	molybdopterin cofactor binding
HVW38_RS01280	COG0437	4 iron, 4 sulfur cluster binding
HVW38_RS01285	COG3302	dmso reductase anchor subunit
HVW38_RS01290	COG3381	protein complex oligomerization
HVW38_RS01310	COG1309	transcriptional regulator
HVW38_RS01315	COG4232	protein-disulfide reductase activity
HVW38_RS01325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVW38_RS01330	COG1027	Aspartate ammonia-lyase
HVW38_RS01335	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVW38_RS01340	COG0531	amino acid
HVW38_RS01365	COG1509	lysine 2,3-aminomutase activity
HVW38_RS01375	COG5510	response to toxic substance
HVW38_RS01380	COG5510	response to toxic substance
HVW38_RS01385	COG2076	Multidrug Resistance protein
HVW38_RS01390	COG3040	lipid binding
HVW38_RS01395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVW38_RS01410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVW38_RS01415	COG1053	succinate dehydrogenase
HVW38_RS01425	COG0531	amino acid
HVW38_RS01435	COG3264	Mechanosensitive ion channel
HVW38_RS01435	COG1511	domain protein
HVW38_RS01455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW38_RS01480	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVW38_RS01485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVW38_RS01485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVW38_RS01490	COG0802	atpase or kinase
HVW38_RS01495	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVW38_RS01515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVW38_RS01520	COG0330	HflC and HflK could
HVW38_RS01525	COG0330	HflC and HflK could
HVW38_RS01530	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVW38_RS01545	COG0557	exoribonuclease II activity
HVW38_RS01550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVW38_RS01555	COG3789	protein conserved in bacteria
HVW38_RS01560	COG1842	Phage shock protein A
HVW38_RS01570	COG3766	membrane
HVW38_RS01575	COG5463	Belongs to the UPF0441 family
HVW38_RS01580	COG0754	glutathionylspermidine amidase activity
HVW38_RS01585	COG1960	acyl-CoA dehydrogenase activity
HVW38_RS01595	COG3650	response to hydrogen peroxide
HVW38_RS01600	COG1073	alpha beta
HVW38_RS01615	COG3037	sugar-specific permease SgaT UlaA
HVW38_RS01620	COG3414	Phosphotransferase system galactitol-specific IIB component
HVW38_RS01660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVW38_RS01670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVW38_RS01695	COG1309	transcriptional regulator
HVW38_RS01700	COG3061	Opacity-associated protein A
HVW38_RS01705	COG0545	Peptidyl-prolyl cis-trans isomerase
HVW38_RS01710	COG1113	amino acid transport
HVW38_RS01720	COG0697	spore germination
HVW38_RS01725	COG0702	epimerase
HVW38_RS01730	COG1733	regulation of RNA biosynthetic process
HVW38_RS01735	COG0737	Belongs to the 5'-nucleotidase family
HVW38_RS01740	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVW38_RS01745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVW38_RS01755	COG1253	flavin adenine dinucleotide binding
HVW38_RS01760	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVW38_RS01770	COG0698	ribose 5-phosphate isomerase
HVW38_RS01775	COG1737	Transcriptional regulator
HVW38_RS01780	COG1879	ABC-type sugar transport system periplasmic component
HVW38_RS01785	COG1129	ABC transporter
HVW38_RS01790	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW38_RS01795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVW38_RS01800	COG1940	carbohydrate kinase activity
HVW38_RS01805	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVW38_RS01815	COG1566	PFAM secretion protein HlyD family protein
HVW38_RS01820	COG1289	transmembrane transporter activity
HVW38_RS01835	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVW38_RS01840	COG1301	dicarboxylic acid transport
HVW38_RS01845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVW38_RS01850	COG3162	membrane
HVW38_RS01865	COG0729	surface antigen
HVW38_RS01870	COG2911	Protein conserved in bacteria
HVW38_RS01875	COG2105	PFAM AIG2 family protein
HVW38_RS01880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVW38_RS01885	COG1879	ABC-type sugar transport system periplasmic component
HVW38_RS01890	COG1129	ABC transporter
HVW38_RS01895	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW38_RS01900	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW38_RS01910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVW38_RS01920	COG0312	modulator of DNA gyrase
HVW38_RS01925	COG3783	Cytochrome b(562)
HVW38_RS01930	COG3077	Addiction module antitoxin, RelB DinJ family
HVW38_RS01940	COG0602	queuosine metabolic process
HVW38_RS01945	COG1328	CTP reductase activity
HVW38_RS01950	COG0366	Alpha amylase catalytic
HVW38_RS01955	COG1263	PTS System
HVW38_RS01955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW38_RS01960	COG1609	Transcriptional regulator
HVW38_RS01970	COG0251	oxidation-reduction process
HVW38_RS01990	COG1438	arginine binding
HVW38_RS01995	COG1288	antiporter activity
HVW38_RS02000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVW38_RS02005	COG0549	Belongs to the carbamate kinase family
HVW38_RS02015	COG2731	YhcH YjgK YiaL family protein
HVW38_RS02020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVW38_RS02025	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVW38_RS02030	COG0456	acetyltransferase
HVW38_RS02040	COG0525	valine-tRNA ligase activity
HVW38_RS02045	COG2927	DNA polymerase III (CHI subunit)
HVW38_RS02055	COG0795	lipopolysaccharide-transporting ATPase activity
HVW38_RS02060	COG0795	lipopolysaccharide-transporting ATPase activity
HVW38_RS02065	COG2823	Periplasmic or secreted lipoprotein
HVW38_RS02085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVW38_RS02095	COG1063	alcohol dehydrogenase
HVW38_RS02100	COG3775	system Galactitol-specific IIC component
HVW38_RS02105	COG3414	Phosphotransferase system galactitol-specific IIB component
HVW38_RS02110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS02125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS02125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS02125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS02130	COG1105	Belongs to the carbohydrate kinase PfkB family
HVW38_RS02140	COG1349	DNA-binding transcription factor activity
HVW38_RS02145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS02150	COG2721	sulfolactate sulfo-lyase activity
HVW38_RS02160	COG2084	Dehydrogenase
HVW38_RS02170	COG1741	Belongs to the pirin family
HVW38_RS02175	COG0583	DNA-binding transcription factor activity
HVW38_RS02180	COG3152	Membrane
HVW38_RS02185	COG0435	Glutathione S-transferase
HVW38_RS02190	COG2259	Doxx family
HVW38_RS02200	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVW38_RS02205	COG4575	ribosome binding
HVW38_RS02210	COG1422	Protein of unknown function (DUF1090)
HVW38_RS02220	COG0586	Pfam SNARE associated Golgi protein
HVW38_RS02225	COG2186	Transcriptional regulator
HVW38_RS02230	COG2271	Major facilitator Superfamily
HVW38_RS02240	COG2721	sulfolactate sulfo-lyase activity
HVW38_RS02250	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVW38_RS02255	COG0861	Integral membrane protein TerC family
HVW38_RS02260	COG0673	inositol 2-dehydrogenase activity
HVW38_RS02265	COG2949	membrane
HVW38_RS02270	COG1451	nucleotide metabolic process
HVW38_RS02295	COG1484	DNA-dependent DNA replication
HVW38_RS02310	COG2966	Psort location CytoplasmicMembrane, score
HVW38_RS02320	COG2169	Transcriptional regulator
HVW38_RS02320	COG1917	Cupin 2, conserved barrel domain protein
HVW38_RS02325	COG2197	response regulator
HVW38_RS02330	COG2197	response regulator
HVW38_RS02335	COG4114	ferric iron reductase
HVW38_RS02365	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVW38_RS02370	COG0456	acetyltransferase
HVW38_RS02375	COG1011	Hydrolase
HVW38_RS02395	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HVW38_RS02400	COG5532	Uncharacterized conserved protein (DUF2303)
HVW38_RS02445	COG1846	Transcriptional regulator
HVW38_RS02450	COG4725	Belongs to the MT-A70-like family
HVW38_RS02455	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVW38_RS02465	COG1403	HNH endonuclease
HVW38_RS02470	COG0484	heat shock protein binding
HVW38_RS02480	COG1278	Cold shock
HVW38_RS02485	COG1278	Cold shock
HVW38_RS02505	COG3772	lysozyme
HVW38_RS02515	COG1278	Cold shock
HVW38_RS02560	COG0740	serine-type endopeptidase activity
HVW38_RS02630	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVW38_RS02640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVW38_RS02665	COG2823	Periplasmic or secreted lipoprotein
HVW38_RS02675	COG4667	esterase of the alpha-beta hydrolase superfamily
HVW38_RS02680	COG0084	hydrolase, TatD family'
HVW38_RS02685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW38_RS02690	COG1328	CTP reductase activity
HVW38_RS02725	COG3726	membrane protein affecting hemolysin expression
HVW38_RS02730	COG0560	Phosphoserine phosphatase
HVW38_RS02735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVW38_RS02740	COG3172	ATPase kinase involved in NAD metabolism
HVW38_RS02740	COG1056	cytidyltransferase-related domain
HVW38_RS02745	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HVW38_RS02755	COG0488	(ABC) transporter
HVW38_RS02760	COG0741	lytic transglycosylase activity
HVW38_RS02780	COG3708	Transcriptional regulator
HVW38_RS02780	COG2207	Transcriptional regulator
HVW38_RS02785	COG3045	CreA protein
HVW38_RS02790	COG0745	RESPONSE REGULATOR receiver
HVW38_RS02795	COG2205	protein histidine kinase activity
HVW38_RS02800	COG4452	Inner membrane protein CreD
HVW38_RS02805	COG0745	RESPONSE REGULATOR receiver
HVW38_RS02815	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVW38_RS02825	COG0460	homoserine dehydrogenase
HVW38_RS02825	COG0527	aspartate kinase activity
HVW38_RS02835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVW38_RS02850	COG1115	amino acid carrier protein
HVW38_RS02860	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVW38_RS02865	COG1584	GPR1 FUN34 yaaH family protein
HVW38_RS02890	COG0583	DNA-binding transcription factor activity
HVW38_RS02905	COG0196	riboflavin kinase activity
HVW38_RS02920	COG1047	Peptidyl-prolyl cis-trans
HVW38_RS02950	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HVW38_RS02955	COG5016	pyruvate
HVW38_RS02955	COG0511	ligase activity, forming carbon-carbon bonds
HVW38_RS03010	COG0505	Belongs to the CarA family
HVW38_RS03015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVW38_RS03065	COG0644	oxidoreductase
HVW38_RS03070	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVW38_RS03075	COG2271	Major facilitator Superfamily
HVW38_RS03090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVW38_RS03130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVW38_RS03140	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVW38_RS03145	COG0564	pseudouridine synthase activity
HVW38_RS03155	COG0417	DNA replication proofreading
HVW38_RS03160	COG0235	Class ii aldolase
HVW38_RS03180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS03190	COG3181	Tripartite tricarboxylate transporter family receptor
HVW38_RS03205	COG0586	Pfam SNARE associated Golgi protein
HVW38_RS03215	COG1178	ABC-type Fe3 transport system permease component
HVW38_RS03220	COG4143	(ABC) transporter
HVW38_RS03250	COG2271	Major facilitator Superfamily
HVW38_RS03255	COG0583	DNA-binding transcription factor activity
HVW38_RS03265	COG0738	Major facilitator superfamily
HVW38_RS03310	COG0028	Belongs to the TPP enzyme family
HVW38_RS03315	COG0440	acetolactate synthase activity
HVW38_RS03325	COG1609	Transcriptional regulator
HVW38_RS03340	COG3116	cell division
HVW38_RS03345	COG0768	penicillin binding
HVW38_RS03350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVW38_RS03355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVW38_RS03370	COG0772	Belongs to the SEDS family
HVW38_RS03385	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVW38_RS03390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVW38_RS03395	COG0849	cell division
HVW38_RS03400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVW38_RS03420	COG0494	nUDIX hydrolase
HVW38_RS03435	COG0237	dephospho-CoA kinase activity
HVW38_RS03445	COG1459	type II secretion system
HVW38_RS03450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVW38_RS03470	COG0157	Belongs to the NadC ModD family
HVW38_RS03480	COG3725	Membrane protein required for beta-lactamase induction
HVW38_RS03485	COG1113	amino acid transport
HVW38_RS03490	COG2186	Transcriptional regulator
HVW38_RS03495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVW38_RS03500	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVW38_RS03505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVW38_RS03510	COG3064	Membrane
HVW38_RS03515	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVW38_RS03540	COG2132	Multicopper oxidase
HVW38_RS03550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVW38_RS03555	COG0288	reversible hydration of carbon dioxide
HVW38_RS03560	COG1131	(ABC) transporter
HVW38_RS03565	COG0842	Transport permease protein
HVW38_RS03570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS03575	COG0726	polysaccharide deacetylase
HVW38_RS03585	COG5464	transposase or invertase
HVW38_RS03610	COG3539	Fimbrial protein
HVW38_RS03615	COG3539	Fimbrial protein
HVW38_RS03620	COG3188	usher protein
HVW38_RS03625	COG3121	Chaperone
HVW38_RS03635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVW38_RS03640	COG0617	tRNA 3'-terminal CCA addition
HVW38_RS03650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVW38_RS03660	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVW38_RS03665	COG1643	Atp-dependent helicase
HVW38_RS03670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVW38_RS03675	COG4774	siderophore transport
HVW38_RS03680	COG1120	ATPase activity
HVW38_RS03685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVW38_RS03690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVW38_RS03715	COG2860	membrane
HVW38_RS03720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVW38_RS03735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVW38_RS03740	COG3835	regulator
HVW38_RS03750	COG1408	metallophosphoesterase
HVW38_RS03765	COG0024	Methionine aminopeptidase
HVW38_RS03790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVW38_RS03795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVW38_RS03800	COG0575	Belongs to the CDS family
HVW38_RS03805	COG0750	zinc metalloprotease
HVW38_RS03815	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVW38_RS03820	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVW38_RS03845	COG0587	DNA-directed DNA polymerase activity
HVW38_RS03860	COG0346	lactoylglutathione lyase activity
HVW38_RS03865	COG0037	tRNA processing
HVW38_RS03870	COG4568	rho-dependent transcription termination
HVW38_RS03880	COG4681	YaeQ
HVW38_RS03885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVW38_RS03890	COG3015	lipoprotein NlpE involved in copper resistance
HVW38_RS03895	COG0791	NLP P60 protein
HVW38_RS03905	COG1720	tRNA m6t6A37 methyltransferase activity
HVW38_RS03915	COG1464	Belongs to the NlpA lipoprotein family
HVW38_RS03920	COG2011	ABC-type metal ion transport system permease component
HVW38_RS03930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVW38_RS03970	COG0583	DNA-binding transcription factor activity
HVW38_RS03980	COG2226	methyltransferase
HVW38_RS03985	COG0741	lytic transglycosylase activity
HVW38_RS03985	COG1388	LysM domain
HVW38_RS03995	COG2226	methyltransferase
HVW38_RS04005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVW38_RS04015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVW38_RS04025	COG1960	acyl-CoA dehydrogenase activity
HVW38_RS04035	COG0121	glutamine amidotransferase
HVW38_RS04040	COG3034	peptidoglycan biosynthetic process
HVW38_RS04045	COG0791	NLP P60 protein
HVW38_RS04055	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVW38_RS04075	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVW38_RS04080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVW38_RS04085	COG2166	iron-sulfur cluster assembly
HVW38_RS04090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVW38_RS04100	COG0583	DNA-binding transcription factor activity
HVW38_RS04105	COG2363	Small membrane protein
HVW38_RS04120	COG1760	l-serine dehydratase
HVW38_RS04125	COG0814	amino acid
HVW38_RS04130	COG1611	Belongs to the LOG family
HVW38_RS04145	COG3098	single-species biofilm formation
HVW38_RS04150	COG0564	pseudouridine synthase activity
HVW38_RS04155	COG0716	FMN binding
HVW38_RS04175	COG4948	Mandelate Racemase Muconate Lactonizing
HVW38_RS04180	COG4948	Mandelate Racemase Muconate Lactonizing
HVW38_RS04185	COG1929	Belongs to the glycerate kinase type-1 family
HVW38_RS04190	COG3850	Histidine kinase
HVW38_RS04190	COG3437	response regulator, receiver
HVW38_RS04190	COG4999	Histidine kinase
HVW38_RS04190	COG2205	protein histidine kinase activity
HVW38_RS04195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVW38_RS04200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVW38_RS04205	COG2336	PFAM SpoVT AbrB
HVW38_RS04210	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVW38_RS04215	COG3956	TIGRFAM MazG family protein
HVW38_RS04230	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVW38_RS04240	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVW38_RS04250	COG0602	queuosine metabolic process
HVW38_RS04255	COG1070	Carbohydrate kinase
HVW38_RS04260	COG2223	nitrite transmembrane transporter activity
HVW38_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS04270	COG0277	FAD linked oxidase domain protein
HVW38_RS04275	COG0477	Major facilitator Superfamily
HVW38_RS04280	COG2086	electron transfer activity
HVW38_RS04285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVW38_RS04290	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HVW38_RS04295	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVW38_RS04300	COG0644	oxidoreductase
HVW38_RS04305	COG0720	synthase
HVW38_RS04325	COG1203	CRISPR-associated helicase, Cas3
HVW38_RS04340	COG1857	crispr-associated protein
HVW38_RS04355	COG1518	maintenance of DNA repeat elements
HVW38_RS04360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVW38_RS04365	COG2234	aminopeptidase activity
HVW38_RS04420	COG1388	LysM domain
HVW38_RS04420	COG4942	peptidase
HVW38_RS04425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVW38_RS04435	COG0163	prenyltransferase activity
HVW38_RS04440	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVW38_RS04450	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVW38_RS04485	COG1129	ABC transporter
HVW38_RS04490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW38_RS04495	COG1879	ABC-type sugar transport system periplasmic component
HVW38_RS04500	COG1349	DNA-binding transcription factor activity
HVW38_RS04515	COG3604	Transcriptional regulator
HVW38_RS04520	COG0309	Hydrogenase expression formation protein (HypE)
HVW38_RS04525	COG0409	Hydrogenase expression formation protein
HVW38_RS04530	COG0298	carbon dioxide binding
HVW38_RS04535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVW38_RS04540	COG0375	protein maturation
HVW38_RS04550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW38_RS04555	COG0651	ATP synthesis coupled electron transport
HVW38_RS04560	COG0650	Formate hydrogenlyase subunit 4
HVW38_RS04565	COG3261	NADH dehydrogenase
HVW38_RS04565	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVW38_RS04570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVW38_RS04575	COG3260	NADH ubiquinone oxidoreductase 20
HVW38_RS04585	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVW38_RS04590	COG2723	6-phospho-beta-galactosidase activity
HVW38_RS04595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW38_RS04595	COG1263	PTS System
HVW38_RS04600	COG1609	Transcriptional regulator
HVW38_RS04605	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW38_RS04610	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVW38_RS04630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVW38_RS04630	COG0517	IMP dehydrogenase activity
HVW38_RS04640	COG2951	lytic endotransglycosylase activity
HVW38_RS04650	COG1546	Belongs to the CinA family
HVW38_RS04670	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVW38_RS04700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW38_RS04705	COG1238	metal cluster binding
HVW38_RS04730	COG2814	Major facilitator Superfamily
HVW38_RS04735	COG1566	PFAM secretion protein HlyD family protein
HVW38_RS04740	COG1846	Transcriptional regulator
HVW38_RS04750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVW38_RS04755	COG2814	Major facilitator Superfamily
HVW38_RS04760	COG2113	Glycine betaine
HVW38_RS04765	COG4176	ABC-type proline glycine betaine transport system permease component
HVW38_RS04770	COG4175	Glycine betaine
HVW38_RS04775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVW38_RS04780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVW38_RS04790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVW38_RS04795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW38_RS04805	COG4575	ribosome binding
HVW38_RS04825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVW38_RS04830	COG0640	Transcriptional regulator
HVW38_RS04835	COG0401	homolog of Blt101
HVW38_RS04840	COG1652	LysM domain
HVW38_RS04845	COG1802	Transcriptional regulator
HVW38_RS04850	COG1113	amino acid transport
HVW38_RS04855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVW38_RS04860	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS04865	COG0579	oxidoreductase
HVW38_RS04875	COG0583	DNA-binding transcription factor activity
HVW38_RS04885	COG0666	response to abiotic stimulus
HVW38_RS04895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVW38_RS04900	COG1304	FMN binding
HVW38_RS04905	COG0549	Belongs to the carbamate kinase family
HVW38_RS04910	COG0402	S-adenosylhomocysteine deaminase activity
HVW38_RS04915	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVW38_RS04925	COG1064	alcohol dehydrogenase
HVW38_RS04930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVW38_RS04935	COG0698	ribose 5-phosphate isomerase
HVW38_RS04945	COG2376	Dihydroxyacetone kinase
HVW38_RS04950	COG0149	triose-phosphate isomerase activity
HVW38_RS04955	COG1082	Xylose isomerase domain protein TIM barrel
HVW38_RS04960	COG2084	Dehydrogenase
HVW38_RS04965	COG2390	Transcriptional regulator
HVW38_RS04970	COG0393	Putative heavy-metal-binding
HVW38_RS04995	COG1484	DNA-dependent DNA replication
HVW38_RS05000	COG4584	PFAM Integrase catalytic
HVW38_RS05045	COG0582	viral genome integration into host DNA
HVW38_RS05060	COG2867	negative regulation of translational initiation
HVW38_RS05070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW38_RS05075	COG0497	DNA recombination
HVW38_RS05090	COG4536	flavin adenine dinucleotide binding
HVW38_RS05095	COG4137	Cytochrome C assembly protein
HVW38_RS05100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVW38_RS05130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVW38_RS05135	COG1605	Chorismate mutase
HVW38_RS05135	COG0287	Prephenate dehydrogenase
HVW38_RS05140	COG0077	Prephenate dehydratase
HVW38_RS05140	COG1605	Chorismate mutase
HVW38_RS05150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVW38_RS05155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW38_RS05160	COG0564	pseudouridine synthase activity
HVW38_RS05170	COG0542	response to heat
HVW38_RS05195	COG0477	Major facilitator Superfamily
HVW38_RS05200	COG5544	Lipoprotein
HVW38_RS05205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVW38_RS05210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVW38_RS05210	COG1042	CoA-binding domain protein
HVW38_RS05210	COG0045	succinate-CoA ligase (ADP-forming) activity
HVW38_RS05220	COG3118	belongs to the thioredoxin family
HVW38_RS05225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVW38_RS05250	COG0513	Belongs to the DEAD box helicase family
HVW38_RS05260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVW38_RS05270	COG1595	DNA-templated transcription, initiation
HVW38_RS05275	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVW38_RS05280	COG3026	antisigma factor binding
HVW38_RS05285	COG3086	response to oxidative stress
HVW38_RS05295	COG0681	Belongs to the peptidase S26 family
HVW38_RS05315	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVW38_RS05330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW38_RS05335	COG1737	Transcriptional regulator
HVW38_RS05340	COG0560	Phosphoserine phosphatase
HVW38_RS05345	COG0590	tRNA wobble adenosine to inosine editing
HVW38_RS05355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVW38_RS05355	COG0047	phosphoribosylformylglycinamidine synthase activity
HVW38_RS05360	COG2205	protein histidine kinase activity
HVW38_RS05365	COG3170	Tfp pilus assembly protein FimV
HVW38_RS05370	COG2204	response regulator
HVW38_RS05375	COG0347	Belongs to the P(II) protein family
HVW38_RS05395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS05410	COG4651	solute:proton antiporter activity
HVW38_RS05410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVW38_RS05415	COG2223	nitrite transmembrane transporter activity
HVW38_RS05420	COG0737	Belongs to the 5'-nucleotidase family
HVW38_RS05435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVW38_RS05440	COG3735	TraB family
HVW38_RS05445	COG2217	Heavy metal translocating P-type atpase
HVW38_RS05450	COG0531	amino acid
HVW38_RS05485	COG0789	Transcriptional regulator
HVW38_RS05490	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVW38_RS05495	COG0330	HflC and HflK could
HVW38_RS05500	COG4619	ABC transporter
HVW38_RS05505	COG0390	transport system, permease component
HVW38_RS05510	COG3118	belongs to the thioredoxin family
HVW38_RS05515	COG0300	oxidoreductase activity
HVW38_RS05520	COG2755	lipolytic protein G-D-S-L family
HVW38_RS05525	COG4181	ATPase activity
HVW38_RS05530	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVW38_RS05550	COG0549	Belongs to the carbamate kinase family
HVW38_RS05555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVW38_RS05560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVW38_RS05570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVW38_RS05580	COG1988	membrane-bound metal-dependent
HVW38_RS05585	COG2501	S4 domain
HVW38_RS05600	COG0582	viral genome integration into host DNA
HVW38_RS05660	COG2246	polysaccharide biosynthetic process
HVW38_RS05670	COG1017	nitric oxide dioxygenase activity
HVW38_RS05670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVW38_RS05685	COG2259	Doxx family
HVW38_RS05690	COG2814	Major facilitator Superfamily
HVW38_RS05695	COG3711	transcriptional antiterminator
HVW38_RS05705	COG0483	inositol monophosphate 1-phosphatase activity
HVW38_RS05725	COG0822	iron-sulfur transferase activity
HVW38_RS05745	COG0633	Ferredoxin
HVW38_RS05750	COG2975	iron-sulfur cluster assembly
HVW38_RS05765	COG2897	thiosulfate sulfurtransferase activity
HVW38_RS05770	COG2373	Large extracellular alpha-helical protein
HVW38_RS05775	COG4953	penicillin-binding protein 1C
HVW38_RS05805	COG2976	Protein conserved in bacteria
HVW38_RS05820	COG1645	bacterial-type flagellum-dependent swarming motility
HVW38_RS05845	COG0516	GMP reductase activity
HVW38_RS05845	COG0517	IMP dehydrogenase activity
HVW38_RS05865	COG3133	Outer membrane lipoprotein
HVW38_RS05875	COG2200	EAL domain
HVW38_RS05880	COG0248	Ppx GppA phosphatase
HVW38_RS05890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVW38_RS05905	COG2233	PERMEase
HVW38_RS05915	COG1393	Belongs to the ArsC family
HVW38_RS05920	COG4783	chaperone-mediated protein folding
HVW38_RS05925	COG0628	permease
HVW38_RS05930	COG3604	Transcriptional regulator
HVW38_RS05940	COG3260	NADH ubiquinone oxidoreductase 20
HVW38_RS05945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVW38_RS05950	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVW38_RS05950	COG3261	NADH dehydrogenase
HVW38_RS05955	COG0651	ATP synthesis coupled electron transport
HVW38_RS05960	COG4237	Hydrogenase 4 membrane
HVW38_RS05965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVW38_RS05970	COG0650	Formate hydrogenlyase subunit 4
HVW38_RS05975	COG0651	ATP synthesis coupled electron transport
HVW38_RS05980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW38_RS05985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVW38_RS05990	COG2716	regulation of RNA biosynthetic process
HVW38_RS06000	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVW38_RS06010	COG2321	neutral zinc metallopeptidase
HVW38_RS06015	COG1444	tRNA N-acetyltransferase activity
HVW38_RS06020	COG0400	carboxylic ester hydrolase activity
HVW38_RS06035	COG1393	Belongs to the ArsC family
HVW38_RS06045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW38_RS06050	COG3850	Histidine kinase
HVW38_RS06055	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW38_RS06055	COG0493	'glutamate synthase
HVW38_RS06065	COG5342	invasion associated locus B
HVW38_RS06070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVW38_RS06075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVW38_RS06080	COG0281	malic enzyme
HVW38_RS06080	COG0280	phosphate acetyltransferase
HVW38_RS06100	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVW38_RS06120	COG2837	iron assimilation
HVW38_RS06125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVW38_RS06130	COG1263	PTS System
HVW38_RS06130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW38_RS06145	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS06150	COG4150	thiosulfate binding
HVW38_RS06155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVW38_RS06160	COG4208	sulfate ABC transporter
HVW38_RS06165	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVW38_RS06170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVW38_RS06175	COG4884	unkown
HVW38_RS06175	COG3831	ATPase activity
HVW38_RS06190	COG2190	(PTS) system
HVW38_RS06195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVW38_RS06200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS06205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVW38_RS06215	COG3115	cell septum assembly
HVW38_RS06225	COG3530	Putative quorum-sensing-regulated virulence factor
HVW38_RS06230	COG0385	Bile acid
HVW38_RS06240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVW38_RS06245	COG2211	Major facilitator Superfamily
HVW38_RS06255	COG0583	DNA-binding transcription factor activity
HVW38_RS06275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVW38_RS06280	COG3415	Transposase
HVW38_RS06285	COG3415	Transposase
HVW38_RS06300	COG2199	diguanylate cyclase activity
HVW38_RS06300	COG2200	EAL domain
HVW38_RS06305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVW38_RS06330	COG3279	Response regulator of the LytR AlgR family
HVW38_RS06335	COG3275	phosphorelay sensor kinase activity
HVW38_RS06340	COG0436	Aminotransferase
HVW38_RS06350	COG1560	Kdo2-lipid A biosynthetic process
HVW38_RS06370	COG0154	amidase activity
HVW38_RS06390	COG4638	Rieske (2fe-2S)
HVW38_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS06410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVW38_RS06425	COG2116	formate transmembrane transporter activity
HVW38_RS06435	COG2067	long-chain fatty acid transport protein
HVW38_RS06440	COG3691	Protein conserved in bacteria
HVW38_RS06455	COG2062	phosphohistidine phosphatase, SixA
HVW38_RS06460	COG3539	Fimbrial protein
HVW38_RS06465	COG3188	usher protein
HVW38_RS06470	COG3121	Chaperone
HVW38_RS06475	COG3539	Fimbrial protein
HVW38_RS06480	COG3539	Fimbrial protein
HVW38_RS06485	COG3539	Fimbrial protein
HVW38_RS06515	COG0730	response to heat
HVW38_RS06520	COG3101	peptidyl-lysine hydroxylation
HVW38_RS06535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW38_RS06555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVW38_RS06565	COG0586	Pfam SNARE associated Golgi protein
HVW38_RS06575	COG0285	dihydrofolate synthase activity
HVW38_RS06580	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVW38_RS06585	COG1286	toxin biosynthetic process
HVW38_RS06590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVW38_RS06595	COG0163	prenyltransferase activity
HVW38_RS06600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW38_RS06605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW38_RS06610	COG4215	(ABC) transporter
HVW38_RS06615	COG4160	amino acid transport
HVW38_RS06620	COG4598	ABC transporter
HVW38_RS06625	COG5464	transposase or invertase
HVW38_RS06630	COG1090	epimerase
HVW38_RS06635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVW38_RS06640	COG0625	glutathione transferase activity
HVW38_RS06645	COG0625	glutathione transferase activity
HVW38_RS06650	COG0622	Phosphoesterase
HVW38_RS06660	COG1609	Transcriptional regulator
HVW38_RS06675	COG3037	sugar-specific permease SgaT UlaA
HVW38_RS06680	COG3959	Transketolase, thiamine diphosphate binding domain
HVW38_RS06685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVW38_RS06695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVW38_RS06710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW38_RS06715	COG0471	metal ion transport
HVW38_RS06715	COG0490	domain, Protein
HVW38_RS06725	COG0436	Aminotransferase
HVW38_RS06730	COG0583	DNA-binding transcription factor activity
HVW38_RS06750	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVW38_RS06755	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVW38_RS06760	COG1034	ATP synthesis coupled electron transport
HVW38_RS06775	COG0839	Belongs to the complex I subunit 6 family
HVW38_RS06785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVW38_RS06790	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVW38_RS06815	COG2304	oxidoreductase activity
HVW38_RS06820	COG0784	Response regulator, receiver
HVW38_RS06820	COG0835	chemotaxis
HVW38_RS06830	COG2153	protein acetylation
HVW38_RS06835	COG4575	ribosome binding
HVW38_RS06840	COG1169	isochorismate synthase
HVW38_RS06855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVW38_RS06865	COG0318	PFAM AMP-dependent synthetase and ligase
HVW38_RS06935	COG5464	transposase or invertase
HVW38_RS06940	COG0247	lactate metabolic process
HVW38_RS06950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVW38_RS06955	COG2271	Major facilitator Superfamily
HVW38_RS06960	COG0584	glycerophosphoryl diester phosphodiesterase
HVW38_RS06965	COG3642	lipopolysaccharide core region biosynthetic process
HVW38_RS06970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVW38_RS06975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVW38_RS06980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVW38_RS06985	COG3468	outer membrane autotransporter barrel domain protein
HVW38_RS06995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVW38_RS07000	COG0183	Belongs to the thiolase family
HVW38_RS07005	COG2031	fatty acid transporter
HVW38_RS07010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVW38_RS07015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVW38_RS07020	COG2204	response regulator
HVW38_RS07025	COG3852	Histidine kinase
HVW38_RS07030	COG0784	Response regulator, receiver
HVW38_RS07030	COG2205	protein histidine kinase activity
HVW38_RS07035	COG2197	response regulator
HVW38_RS07040	COG0642	Histidine kinase
HVW38_RS07040	COG2198	Histidine kinase
HVW38_RS07045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVW38_RS07050	COG1477	protein flavinylation
HVW38_RS07055	COG2169	Transcriptional regulator
HVW38_RS07055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVW38_RS07060	COG3145	DNA-N1-methyladenine dioxygenase activity
HVW38_RS07065	COG4615	Cyclic peptide transporter
HVW38_RS07075	COG1126	abc transporter atp-binding protein
HVW38_RS07080	COG0765	amino acid transport
HVW38_RS07085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW38_RS07095	COG5006	permease, DMT superfamily
HVW38_RS07100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVW38_RS07105	COG2194	sulfuric ester hydrolase activity
HVW38_RS07115	COG1321	iron dependent repressor
HVW38_RS07120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVW38_RS07125	COG1376	ErfK ybiS ycfS ynhG family protein
HVW38_RS07130	COG0488	(ABC) transporter
HVW38_RS07135	COG0561	phosphatase activity
HVW38_RS07140	COG1882	Formate acetyltransferase
HVW38_RS07145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW38_RS07150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVW38_RS07155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVW38_RS07160	COG0303	'Molybdopterin
HVW38_RS07185	COG2200	EAL domain
HVW38_RS07190	COG2199	diguanylate cyclase activity
HVW38_RS07205	COG2133	pyrroloquinoline quinone binding
HVW38_RS07210	COG0625	glutathione transferase activity
HVW38_RS07215	COG1686	Belongs to the peptidase S11 family
HVW38_RS07220	COG1349	DNA-binding transcription factor activity
HVW38_RS07225	COG0671	phosphoesterase, PA-phosphatase related
HVW38_RS07230	COG2814	Major facilitator Superfamily
HVW38_RS07240	COG0561	phosphatase activity
HVW38_RS07245	COG0738	Major facilitator superfamily
HVW38_RS07250	COG3226	Transcriptional regulator
HVW38_RS07285	COG0778	Nitroreductase
HVW38_RS07300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVW38_RS07305	COG3842	ATPase activity
HVW38_RS07310	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVW38_RS07315	COG1177	transmembrane transport
HVW38_RS07330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW38_RS07335	COG4160	amino acid transport
HVW38_RS07340	COG4215	(ABC) transporter
HVW38_RS07345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW38_RS07350	COG1126	abc transporter atp-binding protein
HVW38_RS07365	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVW38_RS07370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVW38_RS07375	COG0702	epimerase
HVW38_RS07380	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVW38_RS07385	COG0028	Belongs to the TPP enzyme family
HVW38_RS07395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVW38_RS07405	COG2431	L-lysine efflux transmembrane transporter activity
HVW38_RS07415	COG3593	DNA synthesis involved in DNA repair
HVW38_RS07420	COG2990	Protein conserved in bacteria
HVW38_RS07425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW38_RS07435	COG1278	Cold shock
HVW38_RS07445	COG0542	response to heat
HVW38_RS07465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVW38_RS07470	COG4988	ABC transporter
HVW38_RS07475	COG0492	ferredoxin-NADP+ reductase activity
HVW38_RS07480	COG1522	sequence-specific DNA binding
HVW38_RS07485	COG1178	ABC-type Fe3 transport system permease component
HVW38_RS07485	COG1674	ftsk spoiiie
HVW38_RS07495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVW38_RS07505	COG1335	isochorismatase
HVW38_RS07515	COG0531	amino acid
HVW38_RS07525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW38_RS07530	COG1882	Formate acetyltransferase
HVW38_RS07535	COG2116	formate transmembrane transporter activity
HVW38_RS07540	COG1944	ATP diphosphatase activity
HVW38_RS07545	COG2323	membrane
HVW38_RS07565	COG0539	negative regulation of cytoplasmic translation
HVW38_RS07575	COG0658	competence protein
HVW38_RS07575	COG2333	competence protein COMEC
HVW38_RS07590	COG3214	Protein conserved in bacteria
HVW38_RS07605	COG3173	Aminoglycoside phosphotransferase
HVW38_RS07610	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVW38_RS07615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVW38_RS07625	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVW38_RS07635	COG2989	Protein conserved in bacteria
HVW38_RS07640	COG3108	Peptidase M15
HVW38_RS07645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVW38_RS07650	COG1448	Aminotransferase
HVW38_RS07670	COG0308	aminopeptidase N
HVW38_RS07675	COG1116	anion transmembrane transporter activity
HVW38_RS07680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVW38_RS07690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVW38_RS07695	COG0431	NADPH-dependent FMN reductase
HVW38_RS07710	COG3217	Mosc domain protein beta barrel domain protein
HVW38_RS07710	COG0633	Ferredoxin
HVW38_RS07720	COG0488	(ABC) transporter
HVW38_RS07725	COG2995	paraquat-inducible protein a
HVW38_RS07730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVW38_RS07730	COG3008	intermembrane lipid transfer
HVW38_RS07735	COG3009	Protein conserved in bacteria
HVW38_RS07740	COG3130	regulation of translation
HVW38_RS07750	COG1067	ATP-dependent peptidase activity
HVW38_RS07770	COG3070	regulator of competence-specific genes
HVW38_RS07775	COG1289	transmembrane transporter activity
HVW38_RS07780	COG3304	Inner membrane component domain
HVW38_RS07785	COG0210	DNA helicase
HVW38_RS07800	COG1832	CoA-binding protein
HVW38_RS07815	COG1254	Belongs to the acylphosphatase family
HVW38_RS07820	COG2920	part of a sulfur-relay system
HVW38_RS07825	COG0670	Belongs to the BI1 family
HVW38_RS07840	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVW38_RS07845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVW38_RS07850	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVW38_RS07855	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVW38_RS07860	COG1999	signal sequence binding
HVW38_RS07865	COG1773	rubredoxin
HVW38_RS07870	COG3012	SEC-C Motif Domain Protein
HVW38_RS07870	COG3318	Belongs to the UPF0149 family
HVW38_RS07875	COG0814	amino acid
HVW38_RS07885	COG1528	Iron-storage protein
HVW38_RS07895	COG1528	Iron-storage protein
HVW38_RS07900	COG1879	ABC-type sugar transport system periplasmic component
HVW38_RS07905	COG1129	ABC transporter
HVW38_RS07910	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW38_RS07915	COG1877	trehalose-phosphatase activity
HVW38_RS07925	COG0589	response to stress
HVW38_RS07940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVW38_RS07950	COG2198	Histidine kinase
HVW38_RS07950	COG0643	Histidine kinase
HVW38_RS07985	COG0840	transmembrane signaling receptor activity
HVW38_RS08000	COG0745	RESPONSE REGULATOR receiver
HVW38_RS08030	COG0583	DNA-binding transcription factor activity
HVW38_RS08055	COG3729	General stress protein
HVW38_RS08060	COG1309	transcriptional regulator
HVW38_RS08065	COG2200	EAL domain
HVW38_RS08070	COG2199	diguanylate cyclase activity
HVW38_RS08080	COG1215	transferase activity, transferring glycosyl groups
HVW38_RS08085	COG0425	Belongs to the sulfur carrier protein TusA family
HVW38_RS08090	COG2391	methyltransferase activity
HVW38_RS08100	COG0366	Alpha amylase catalytic
HVW38_RS08155	COG2197	response regulator
HVW38_RS08165	COG2197	response regulator
HVW38_RS08245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVW38_RS08260	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVW38_RS08345	COG4695	Portal protein
HVW38_RS08360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HVW38_RS08455	COG4974	Belongs to the 'phage' integrase family
HVW38_RS08460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVW38_RS08465	COG1271	oxidase subunit
HVW38_RS08470	COG1294	oxidase, subunit
HVW38_RS08485	COG0784	Response regulator, receiver
HVW38_RS08485	COG2205	protein histidine kinase activity
HVW38_RS08485	COG2198	Histidine kinase
HVW38_RS08490	COG1879	ABC-type sugar transport system periplasmic component
HVW38_RS08495	COG0745	RESPONSE REGULATOR receiver
HVW38_RS08500	COG3005	denitrification pathway
HVW38_RS08505	COG0243	molybdopterin cofactor binding
HVW38_RS08520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVW38_RS08535	COG3102	Protein conserved in bacteria
HVW38_RS08555	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVW38_RS08560	COG1801	Protein of unknown function DUF72
HVW38_RS08565	COG1335	isochorismatase
HVW38_RS08575	COG0494	nUDIX hydrolase
HVW38_RS08580	COG0217	transcriptional regulatory protein
HVW38_RS08620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVW38_RS08630	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVW38_RS08635	COG0739	heme binding
HVW38_RS08640	COG1560	Kdo2-lipid A biosynthetic process
HVW38_RS08645	COG0469	pyruvate kinase activity
HVW38_RS08650	COG1737	Transcriptional regulator
HVW38_RS08655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVW38_RS08660	COG0129	dihydroxy-acid dehydratase activity
HVW38_RS08665	COG0800	Aldolase
HVW38_RS08675	COG3141	response to X-ray
HVW38_RS08685	COG2979	Protein of unknown function (DUF533)
HVW38_RS08690	COG1770	oligopeptidase
HVW38_RS08695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVW38_RS08700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVW38_RS08710	COG2372	response to copper ion
HVW38_RS08715	COG1276	copper resistance
HVW38_RS08725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVW38_RS08745	COG3008	intermembrane lipid transfer
HVW38_RS08750	COG2995	paraquat-inducible protein a
HVW38_RS08755	COG1956	GAF domain-containing protein
HVW38_RS08775	COG2814	Major facilitator Superfamily
HVW38_RS08780	COG1414	Transcriptional regulator
HVW38_RS08810	COG2226	methyltransferase
HVW38_RS08825	COG3716	PTS system mannose fructose sorbose family IID component
HVW38_RS08830	COG3715	PTS system
HVW38_RS08835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW38_RS08835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS08840	COG1253	flavin adenine dinucleotide binding
HVW38_RS08845	COG2200	EAL domain
HVW38_RS08850	COG1760	l-serine dehydratase
HVW38_RS08860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVW38_RS08880	COG0251	oxidation-reduction process
HVW38_RS08895	COG1199	ATP-dependent helicase activity
HVW38_RS08900	COG1214	PFAM Peptidase M22, glycoprotease
HVW38_RS08905	COG3065	identical protein binding
HVW38_RS08910	COG0318	PFAM AMP-dependent synthetase and ligase
HVW38_RS08915	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVW38_RS08920	COG1388	LysM domain
HVW38_RS08920	COG1376	ErfK ybiS ycfS ynhG family protein
HVW38_RS08925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVW38_RS08930	COG4763	Acyl-transferase
HVW38_RS08935	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVW38_RS08945	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVW38_RS08955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVW38_RS08960	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVW38_RS08970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVW38_RS08975	COG1177	transmembrane transport
HVW38_RS09010	COG3139	Protein of unknown function (DUF1315)
HVW38_RS09015	COG1335	isochorismatase
HVW38_RS09020	COG0252	asparaginase activity
HVW38_RS09030	COG0616	signal peptide processing
HVW38_RS09035	COG0778	Nitroreductase
HVW38_RS09045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVW38_RS09065	COG0494	nUDIX hydrolase
HVW38_RS09070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVW38_RS09075	COG2897	thiosulfate sulfurtransferase activity
HVW38_RS09080	COG4136	ATPase activity
HVW38_RS09085	COG4135	transport system, permease component
HVW38_RS09090	COG4134	Bacterial extracellular solute-binding protein
HVW38_RS09095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW38_RS09100	COG0398	Pfam SNARE associated Golgi protein
HVW38_RS09105	COG0398	Pfam SNARE associated Golgi protein
HVW38_RS09110	COG0708	Exodeoxyribonuclease III
HVW38_RS09140	COG3678	ATP-independent chaperone mediated protein folding
HVW38_RS09150	COG0322	excinuclease ABC activity
HVW38_RS09160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW38_RS09165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVW38_RS09170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVW38_RS09175	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVW38_RS09180	COG1917	Cupin 2, conserved barrel domain protein
HVW38_RS09180	COG2169	Transcriptional regulator
HVW38_RS09185	COG1486	melibiose metabolic process
HVW38_RS09195	COG0753	catalase activity
HVW38_RS09210	COG1988	membrane-bound metal-dependent
HVW38_RS09215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW38_RS09225	COG3001	Fructosamine kinase
HVW38_RS09235	COG1105	Belongs to the carbohydrate kinase PfkB family
HVW38_RS09240	COG3137	Salt-induced outer membrane protein
HVW38_RS09300	COG0791	NLP P60 protein
HVW38_RS09315	COG4256	Hemin uptake protein
HVW38_RS09320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVW38_RS09330	COG0574	Belongs to the PEP-utilizing enzyme family
HVW38_RS09330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVW38_RS09345	COG0628	permease
HVW38_RS09350	COG0277	FAD linked oxidase domain protein
HVW38_RS09350	COG0247	lactate metabolic process
HVW38_RS09355	COG2050	protein possibly involved in aromatic compounds catabolism
HVW38_RS09365	COG0316	Belongs to the HesB IscA family
HVW38_RS09370	COG0719	Fe-S assembly protein
HVW38_RS09375	COG0396	ATPase activity
HVW38_RS09380	COG0719	Fe-S assembly protein
HVW38_RS09395	COG1376	ErfK ybiS ycfS ynhG family protein
HVW38_RS09400	COG4238	major outer membrane lipoprotein
HVW38_RS09405	COG0469	pyruvate kinase activity
HVW38_RS09415	COG4529	Protein conserved in bacteria
HVW38_RS09440	COG0307	riboflavin synthase, alpha
HVW38_RS09445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVW38_RS09450	COG2814	Major facilitator Superfamily
HVW38_RS09455	COG0583	DNA-binding transcription factor activity
HVW38_RS09470	COG2814	Major facilitator Superfamily
HVW38_RS09475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVW38_RS09480	COG0791	NLP P60 protein
HVW38_RS09485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVW38_RS09490	COG1201	RNA secondary structure unwinding
HVW38_RS09500	COG0346	lactoylglutathione lyase activity
HVW38_RS09505	COG1902	pentaerythritol trinitrate reductase activity
HVW38_RS09510	COG1309	transcriptional regulator
HVW38_RS09515	COG3313	Fe-S protein
HVW38_RS09520	COG4989	oxidoreductase activity
HVW38_RS09525	COG2032	superoxide dismutase activity
HVW38_RS09530	COG1289	transmembrane transporter activity
HVW38_RS09535	COG1566	PFAM secretion protein HlyD family protein
HVW38_RS09550	COG3133	Outer membrane lipoprotein
HVW38_RS09560	COG3895	Periplasmic Protein
HVW38_RS09580	COG0625	glutathione transferase activity
HVW38_RS09585	COG3104	oligopeptide transport
HVW38_RS09590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVW38_RS09600	COG4659	FMN binding
HVW38_RS09640	COG0673	inositol 2-dehydrogenase activity
HVW38_RS09650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVW38_RS09655	COG5339	Protein conserved in bacteria
HVW38_RS09660	COG1482	cell wall glycoprotein biosynthetic process
HVW38_RS09665	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW38_RS09665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW38_RS09670	COG0114	fumarate hydratase activity
HVW38_RS09680	COG2205	protein histidine kinase activity
HVW38_RS09685	COG0745	RESPONSE REGULATOR receiver
HVW38_RS09690	COG3136	membrane protein required for alginate biosynthesis
HVW38_RS09700	COG0531	amino acid
HVW38_RS09710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVW38_RS09715	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVW38_RS09725	COG3591	Belongs to the peptidase S1B family
HVW38_RS09740	COG2814	Major facilitator Superfamily
HVW38_RS09745	COG0583	DNA-binding transcription factor activity
HVW38_RS09750	COG1940	carbohydrate kinase activity
HVW38_RS09755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVW38_RS09790	COG3238	Protein conserved in bacteria
HVW38_RS09795	COG1247	-acetyltransferase
HVW38_RS09800	COG2130	NADP-dependent
HVW38_RS09805	COG1802	Transcriptional regulator
HVW38_RS09810	COG4772	TonB-dependent receptor
HVW38_RS09815	COG3391	amine dehydrogenase activity
HVW38_RS09820	COG1113	amino acid transport
HVW38_RS09825	COG0625	glutathione transferase activity
HVW38_RS09830	COG4251	negative regulation of phosphorylation
HVW38_RS09830	COG5001	Diguanylate cyclase
HVW38_RS09830	COG3706	GGDEF domain
HVW38_RS09830	COG2203	Gaf domain
HVW38_RS09835	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVW38_RS09845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVW38_RS09855	COG0384	phenazine biosynthesis protein PhzF
HVW38_RS09865	COG1609	Transcriptional regulator
HVW38_RS09875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVW38_RS09880	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVW38_RS09885	COG1414	Transcriptional regulator
HVW38_RS09890	COG4948	Mandelate Racemase Muconate Lactonizing
HVW38_RS09895	COG4829	muconolactone delta-isomerase
HVW38_RS09900	COG3485	protocatechuate 3,4-dioxygenase
HVW38_RS09935	COG0697	spore germination
HVW38_RS09945	COG0437	4 iron, 4 sulfur cluster binding
HVW38_RS09950	COG2864	formate dehydrogenase
HVW38_RS09955	COG3093	addiction module antidote protein HigA
HVW38_RS09965	COG1064	alcohol dehydrogenase
HVW38_RS09985	COG1764	response to oxidative stress
HVW38_RS09995	COG0583	DNA-binding transcription factor activity
HVW38_RS10000	COG3485	protocatechuate 3,4-dioxygenase
HVW38_RS10010	COG5383	Protein conserved in bacteria
HVW38_RS10020	COG2841	Protein conserved in bacteria
HVW38_RS10025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVW38_RS10030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVW38_RS10035	COG0500	methyltransferase
HVW38_RS10045	COG0826	peptidase U32
HVW38_RS10065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVW38_RS10070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVW38_RS10075	COG3842	ATPase activity
HVW38_RS10080	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVW38_RS10085	COG1177	transmembrane transport
HVW38_RS10115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVW38_RS10130	COG4948	Mandelate Racemase Muconate Lactonizing
HVW38_RS10140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVW38_RS10150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVW38_RS10155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVW38_RS10160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVW38_RS10160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVW38_RS10180	COG1802	Transcriptional regulator
HVW38_RS10185	COG4221	oxidoreductase activity
HVW38_RS10190	COG0339	signal peptide processing
HVW38_RS10195	COG1546	Belongs to the CinA family
HVW38_RS10200	COG3111	PFAM Bacterial OB fold (BOF) protein
HVW38_RS10205	COG3706	GGDEF domain
HVW38_RS10210	COG2814	Major facilitator Superfamily
HVW38_RS10215	COG0697	spore germination
HVW38_RS10225	COG4977	sequence-specific DNA binding
HVW38_RS10230	COG1846	Transcriptional regulator
HVW38_RS10235	COG2095	MarC family integral membrane protein
HVW38_RS10245	COG0583	DNA-binding transcription factor activity
HVW38_RS10250	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS10255	COG2066	Belongs to the glutaminase family
HVW38_RS10265	COG2199	diguanylate cyclase activity
HVW38_RS10275	COG3781	membrane
HVW38_RS10330	COG2207	Transcriptional regulator
HVW38_RS10350	COG4178	(ABC) transporter
HVW38_RS10355	COG4771	TonB-dependent receptor
HVW38_RS10360	COG0612	Peptidase, M16
HVW38_RS10365	COG0076	glutamate decarboxylase activity
HVW38_RS10370	COG0531	amino acid
HVW38_RS10380	COG3706	GGDEF domain
HVW38_RS10385	COG2200	EAL domain
HVW38_RS10385	COG2199	diguanylate cyclase activity
HVW38_RS10385	COG2202	Pas domain
HVW38_RS10400	COG3038	cytochrome b561
HVW38_RS10405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVW38_RS10410	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVW38_RS10425	COG1643	Atp-dependent helicase
HVW38_RS10435	COG0671	phosphoesterase, PA-phosphatase related
HVW38_RS10435	COG2453	phosphatase
HVW38_RS10450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVW38_RS10460	COG0667	Aldo Keto reductase
HVW38_RS10465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVW38_RS10470	COG3327	negative regulation of DNA-templated transcription, initiation
HVW38_RS10475	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVW38_RS10480	COG0183	Belongs to the thiolase family
HVW38_RS10485	COG2050	protein possibly involved in aromatic compounds catabolism
HVW38_RS10490	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVW38_RS10495	COG1024	Enoyl-CoA hydratase
HVW38_RS10500	COG1024	Enoyl-CoA hydratase
HVW38_RS10505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVW38_RS10510	COG2151	metal-sulfur cluster biosynthetic enzyme
HVW38_RS10515	COG3396	Phenylacetate-CoA oxygenase
HVW38_RS10520	COG3460	Phenylacetate-CoA oxygenase
HVW38_RS10525	COG3396	Phenylacetate-CoA oxygenase
HVW38_RS10530	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS10530	COG2030	dehydratase
HVW38_RS10535	COG3733	amine oxidase
HVW38_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS10545	COG2207	Transcriptional regulator
HVW38_RS10550	COG3784	Protein of unknown function (DUF1318)
HVW38_RS10560	COG2911	Protein conserved in bacteria
HVW38_RS10565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVW38_RS10570	COG3187	Heat shock protein
HVW38_RS10575	COG3042	response to heat
HVW38_RS10585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVW38_RS10585	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVW38_RS10585	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVW38_RS10585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVW38_RS10590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVW38_RS10595	COG0589	response to stress
HVW38_RS10605	COG0513	Belongs to the DEAD box helicase family
HVW38_RS10620	COG3706	GGDEF domain
HVW38_RS10625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW38_RS10630	COG0596	Alpha beta hydrolase
HVW38_RS10640	COG0183	Belongs to the thiolase family
HVW38_RS10645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVW38_RS10655	COG1414	Transcriptional regulator
HVW38_RS10660	COG2840	Smr protein MutS2
HVW38_RS10665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVW38_RS10670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW38_RS10675	COG0589	response to stress
HVW38_RS10680	COG3182	Iron-regulated membrane protein
HVW38_RS10685	COG0668	transmembrane transport
HVW38_RS10690	COG4166	transmembrane transport
HVW38_RS10695	COG2866	Carboxypeptidase
HVW38_RS10700	COG4948	Mandelate Racemase Muconate Lactonizing
HVW38_RS10705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVW38_RS10710	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVW38_RS10720	COG3106	COG3106 Predicted ATPase
HVW38_RS10725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVW38_RS10735	COG1983	PspC domain protein
HVW38_RS10745	COG1842	Phage shock protein A
HVW38_RS10750	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVW38_RS10755	COG4166	transmembrane transport
HVW38_RS10760	COG4168	peptide transport system, permease
HVW38_RS10765	COG4171	peptide transport system, permease
HVW38_RS10770	COG4172	Belongs to the ABC transporter superfamily
HVW38_RS10775	COG4172	Belongs to the ABC transporter superfamily
HVW38_RS10780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVW38_RS10785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW38_RS10785	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW38_RS10795	COG5001	Diguanylate cyclase
HVW38_RS10805	COG1349	DNA-binding transcription factor activity
HVW38_RS10815	COG0023	Translation Initiation Factor
HVW38_RS10825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVW38_RS10830	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVW38_RS10835	COG0671	phosphoesterase, PA-phosphatase related
HVW38_RS10865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVW38_RS10875	COG0616	signal peptide processing
HVW38_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS10885	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVW38_RS10890	COG1187	pseudouridine synthase activity
HVW38_RS10900	COG0009	L-threonylcarbamoyladenylate synthase
HVW38_RS10905	COG0613	PHP domain protein
HVW38_RS10915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVW38_RS10920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVW38_RS10920	COG0512	Glutamine amidotransferase of anthranilate synthase
HVW38_RS10925	COG0135	phosphoribosylanthranilate isomerase activity
HVW38_RS10925	COG0134	indole-3-glycerol-phosphate synthase activity
HVW38_RS10940	COG3047	cAMP biosynthetic process
HVW38_RS10945	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVW38_RS10960	COG1607	acyl-coa hydrolase
HVW38_RS10970	COG2350	Protein conserved in bacteria
HVW38_RS10990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW38_RS10995	COG4608	Belongs to the ABC transporter superfamily
HVW38_RS11000	COG0444	Belongs to the ABC transporter superfamily
HVW38_RS11020	COG2095	MarC family integral membrane protein
HVW38_RS11025	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS11025	COG1454	alcohol dehydrogenase
HVW38_RS11035	COG1435	thymidine kinase activity
HVW38_RS11045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVW38_RS11050	COG0745	RESPONSE REGULATOR receiver
HVW38_RS11055	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVW38_RS11065	COG0788	formyltetrahydrofolate deformylase activity
HVW38_RS11110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVW38_RS11115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVW38_RS11120	COG2181	nitrate reductase activity
HVW38_RS11125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVW38_RS11130	COG1140	nitrate reductase beta subunit
HVW38_RS11135	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVW38_RS11140	COG2223	nitrite transmembrane transporter activity
HVW38_RS11145	COG3850	Histidine kinase
HVW38_RS11150	COG2197	response regulator
HVW38_RS11155	COG4932	domain protein
HVW38_RS11160	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVW38_RS11165	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVW38_RS11170	COG4572	Cation transport regulator
HVW38_RS11175	COG0387	Pfam Sodium calcium exchanger
HVW38_RS11195	COG2890	protein-(glutamine-N5) methyltransferase activity
HVW38_RS11220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVW38_RS11225	COG0659	secondary active sulfate transmembrane transporter activity
HVW38_RS11240	COG0012	GTP binding
HVW38_RS11255	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVW38_RS11265	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVW38_RS11275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVW38_RS11285	COG2719	SpoVR family
HVW38_RS11300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVW38_RS11305	COG1388	LysM domain
HVW38_RS11305	COG1470	cell adhesion involved in biofilm formation
HVW38_RS11315	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVW38_RS11330	COG2894	cell division
HVW38_RS11340	COG1124	(ABC) transporter
HVW38_RS11350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVW38_RS11355	COG0601	transmembrane transport
HVW38_RS11360	COG0747	negative chemotaxis
HVW38_RS11375	COG1473	amidohydrolase
HVW38_RS11385	COG0217	transcriptional regulatory protein
HVW38_RS11395	COG4932	domain protein
HVW38_RS11395	COG1388	LysM domain
HVW38_RS11395	COG2373	Large extracellular alpha-helical protein
HVW38_RS11415	COG0582	viral genome integration into host DNA
HVW38_RS11420	COG0538	isocitrate dehydrogenase activity
HVW38_RS11425	COG1187	pseudouridine synthase activity
HVW38_RS11445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVW38_RS11450	COG0745	RESPONSE REGULATOR receiver
HVW38_RS11455	COG2205	protein histidine kinase activity
HVW38_RS11460	COG2850	peptidyl-arginine hydroxylation
HVW38_RS11465	COG0656	L-ascorbic acid biosynthetic process
HVW38_RS11470	COG3713	MltA-interacting MipA family protein
HVW38_RS11475	COG2766	serine protein kinase
HVW38_RS11485	COG2199	diguanylate cyclase activity
HVW38_RS11490	COG2199	diguanylate cyclase activity
HVW38_RS11495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVW38_RS11510	COG2807	transmembrane transport
HVW38_RS11515	COG3189	MarR family transcriptional regulator
HVW38_RS11520	COG3042	response to heat
HVW38_RS11525	COG2199	diguanylate cyclase activity
HVW38_RS11525	COG2203	Gaf domain
HVW38_RS11540	COG2261	transglycosylase associated protein
HVW38_RS11550	COG3134	Outer membrane lipoprotein
HVW38_RS11555	COG1252	NADH dehydrogenase
HVW38_RS11570	COG0510	thiamine kinase activity
HVW38_RS11575	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVW38_RS11580	COG5633	Lipoprotein
HVW38_RS11585	COG0537	adenosine 5'-monophosphoramidase activity
HVW38_RS11595	COG0084	hydrolase, TatD family'
HVW38_RS11600	COG0470	DNA polymerase III
HVW38_RS11610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVW38_RS11615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVW38_RS11620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW38_RS11630	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS11635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVW38_RS11655	COG1399	metal-binding, possibly nucleic acid-binding protein
HVW38_RS11660	COG0424	maF-like protein
HVW38_RS11665	COG0564	pseudouridine synthase activity
HVW38_RS11670	COG1530	ribonuclease E activity
HVW38_RS11675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVW38_RS11680	COG1256	bacterial-type flagellum assembly
HVW38_RS11685	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVW38_RS11685	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVW38_RS11705	COG4787	bacterial-type flagellum-dependent cell motility
HVW38_RS11710	COG1749	Flagellar hook protein flgE
HVW38_RS11715	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVW38_RS11720	COG1558	bacterial-type flagellum-dependent cell motility
HVW38_RS11735	COG2747	anti-sigma28 factor FlgM
HVW38_RS11745	COG0728	peptidoglycan biosynthetic process
HVW38_RS11750	COG0673	inositol 2-dehydrogenase activity
HVW38_RS11760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVW38_RS11795	COG3038	cytochrome b561
HVW38_RS11800	COG2353	YceI-like domain
HVW38_RS11810	COG1560	Kdo2-lipid A biosynthetic process
HVW38_RS11825	COG5645	(Lipo)protein
HVW38_RS11830	COG2943	transferase activity, transferring hexosyl groups
HVW38_RS11845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVW38_RS11890	COG1462	curli production assembly transport component CsgG
HVW38_RS11900	COG3381	protein complex oligomerization
HVW38_RS11930	COG0402	S-adenosylhomocysteine deaminase activity
HVW38_RS11935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVW38_RS11940	COG3104	oligopeptide transport
HVW38_RS11945	COG1982	Orn Lys Arg decarboxylase major
HVW38_RS11950	COG0531	amino acid
HVW38_RS11955	COG3710	Transcriptional regulator
HVW38_RS11960	COG3706	GGDEF domain
HVW38_RS11965	COG0457	Tetratricopeptide repeat
HVW38_RS11970	COG0726	polysaccharide deacetylase
HVW38_RS11970	COG1649	PFAM Uncharacterised BCR, COG1649
HVW38_RS11975	COG1215	transferase activity, transferring glycosyl groups
HVW38_RS11980	COG3658	cytochrome
HVW38_RS11985	COG1702	phosphate starvation-inducible protein PhoH
HVW38_RS11995	COG2822	iron ion transport
HVW38_RS12005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVW38_RS12015	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVW38_RS12015	COG0506	proline dehydrogenase activity
HVW38_RS12015	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVW38_RS12020	COG1560	Kdo2-lipid A biosynthetic process
HVW38_RS12025	COG2990	Protein conserved in bacteria
HVW38_RS12030	COG0438	transferase activity, transferring glycosyl groups
HVW38_RS12035	COG0726	polysaccharide deacetylase
HVW38_RS12040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVW38_RS12045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVW38_RS12055	COG1766	The M ring may be actively involved in energy transduction
HVW38_RS12060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVW38_RS12065	COG1317	bacterial-type flagellum organization
HVW38_RS12070	COG1157	protein secretion by the type III secretion system
HVW38_RS12075	COG2882	bacterial-type flagellum organization
HVW38_RS12080	COG3144	bacterial-type flagellum assembly
HVW38_RS12085	COG1580	Controls the rotational direction of flagella during chemotaxis
HVW38_RS12090	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVW38_RS12095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVW38_RS12100	COG3190	flagellar
HVW38_RS12105	COG1338	Plays a role in the flagellum-specific transport system
HVW38_RS12120	COG2197	response regulator
HVW38_RS12145	COG5475	Uncharacterized small protein (DUF2158)
HVW38_RS12150	COG2354	Protein conserved in bacteria
HVW38_RS12160	COG3727	T/G mismatch-specific endonuclease activity
HVW38_RS12165	COG1418	mRNA catabolic process
HVW38_RS12175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVW38_RS12185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVW38_RS12230	COG3423	Transcriptional regulator
HVW38_RS12260	COG0583	DNA-binding transcription factor activity
HVW38_RS12305	COG3157	Type VI secretion system effector, Hcp
HVW38_RS12385	COG3501	Rhs element vgr protein
HVW38_RS12405	COG5433	transposase activity
HVW38_RS12425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVW38_RS12430	COG0477	Major facilitator Superfamily
HVW38_RS12440	COG0534	Mate efflux family protein
HVW38_RS12480	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS12480	COG1454	alcohol dehydrogenase
HVW38_RS12490	COG1454	alcohol dehydrogenase
HVW38_RS12490	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS12495	COG1882	Formate acetyltransferase
HVW38_RS12500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW38_RS12510	COG4869	propanediol catabolic process
HVW38_RS12530	COG1376	ErfK ybiS ycfS ynhG family protein
HVW38_RS12615	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS12625	COG4656	Part of a membrane complex involved in electron transport
HVW38_RS12655	COG1289	transmembrane transporter activity
HVW38_RS12665	COG2925	Exonuclease
HVW38_RS12670	COG0425	Belongs to the sulfur carrier protein TusA family
HVW38_RS12675	COG2391	methyltransferase activity
HVW38_RS12680	COG0531	amino acid
HVW38_RS12690	COG0583	DNA-binding transcription factor activity
HVW38_RS12695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVW38_RS12710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVW38_RS12720	COG0131	Imidazoleglycerol-phosphate dehydratase
HVW38_RS12720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVW38_RS12725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVW38_RS12750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HVW38_RS12755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVW38_RS12800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVW38_RS12805	COG1091	dTDP-4-dehydrorhamnose reductase activity
HVW38_RS12810	COG1088	dTDP-glucose 4,6-dehydratase activity
HVW38_RS12815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVW38_RS12820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVW38_RS12830	COG0438	transferase activity, transferring glycosyl groups
HVW38_RS12835	COG2327	Polysaccharide pyruvyl transferase
HVW38_RS12840	COG2244	polysaccharide biosynthetic process
HVW38_RS12845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVW38_RS12850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVW38_RS12855	COG0662	Cupin 2, conserved barrel domain protein
HVW38_RS12855	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVW38_RS12860	COG0297	glycogen (starch) synthase activity
HVW38_RS12865	COG1051	belongs to the nudix hydrolase family
HVW38_RS12870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVW38_RS12875	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVW38_RS12880	COG0110	maltose O-acetyltransferase activity
HVW38_RS12885	COG1216	Glycosyl transferase, family 2
HVW38_RS12895	COG0438	transferase activity, transferring glycosyl groups
HVW38_RS12900	COG1045	serine acetyltransferase
HVW38_RS12905	COG0463	Glycosyl transferase, family 2
HVW38_RS12910	COG0489	protein tyrosine kinase activity
HVW38_RS12910	COG3206	protein involved in exopolysaccharide biosynthesis
HVW38_RS12915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVW38_RS12920	COG1596	polysaccharide export
HVW38_RS12930	COG1253	flavin adenine dinucleotide binding
HVW38_RS12945	COG2982	Protein involved in outer membrane biogenesis
HVW38_RS12960	COG5001	Diguanylate cyclase
HVW38_RS12960	COG3447	MASE1 domain protein
HVW38_RS12960	COG5002	protein histidine kinase activity
HVW38_RS12965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVW38_RS12970	COG0443	Heat shock 70 kDa protein
HVW38_RS12975	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVW38_RS12980	COG3779	Protein conserved in bacteria
HVW38_RS12985	COG0631	protein serine/threonine phosphatase activity
HVW38_RS12990	COG4245	von Willebrand factor, type A
HVW38_RS13020	COG2205	protein histidine kinase activity
HVW38_RS13025	COG0745	RESPONSE REGULATOR receiver
HVW38_RS13035	COG3609	addiction module antidote protein, CC2985 family
HVW38_RS13055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW38_RS13065	COG1070	Carbohydrate kinase
HVW38_RS13090	COG1069	ribulokinase activity
HVW38_RS13100	COG1830	Aldolase
HVW38_RS13105	COG2211	Major facilitator Superfamily
HVW38_RS13110	COG1397	ADP-ribosylglycohydrolase
HVW38_RS13115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS13120	COG2188	Transcriptional regulator
HVW38_RS13125	COG3757	hydrolase, family 25
HVW38_RS13130	COG0351	phosphomethylpyrimidine kinase
HVW38_RS13140	COG4626	Terminase
HVW38_RS13140	COG1802	Transcriptional regulator
HVW38_RS13245	COG5455	response to cobalt ion
HVW38_RS13250	COG3539	Fimbrial protein
HVW38_RS13255	COG3188	usher protein
HVW38_RS13260	COG3121	Chaperone
HVW38_RS13275	COG0489	protein tyrosine kinase activity
HVW38_RS13285	COG3831	ATPase activity
HVW38_RS13290	COG3831	ATPase activity
HVW38_RS13295	COG3831	ATPase activity
HVW38_RS13300	COG3831	ATPase activity
HVW38_RS13310	COG0714	Associated with various cellular activities
HVW38_RS13315	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVW38_RS13320	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVW38_RS13325	COG4715	Zinc finger, swim domain protein
HVW38_RS13330	COG4808	Protein conserved in bacteria
HVW38_RS13335	COG4807	Protein conserved in bacteria
HVW38_RS13345	COG3275	phosphorelay sensor kinase activity
HVW38_RS13350	COG0789	Transcriptional regulator
HVW38_RS13360	COG1174	glycine betaine transport
HVW38_RS13365	COG1125	glycine betaine transport
HVW38_RS13370	COG1174	glycine betaine transport
HVW38_RS13375	COG1732	Glycine betaine
HVW38_RS13380	COG1472	Belongs to the glycosyl hydrolase 3 family
HVW38_RS13385	COG0277	FAD linked oxidase domain protein
HVW38_RS13390	COG1686	Belongs to the peptidase S11 family
HVW38_RS13400	COG0586	Pfam SNARE associated Golgi protein
HVW38_RS13405	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS13415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVW38_RS13425	COG1346	cytolysis
HVW38_RS13435	COG2949	membrane
HVW38_RS13445	COG0493	'glutamate synthase
HVW38_RS13450	COG0167	dihydroorotate dehydrogenase activity
HVW38_RS13450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVW38_RS13455	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVW38_RS13460	COG1129	ABC transporter
HVW38_RS13465	COG1879	ABC-type sugar transport system periplasmic component
HVW38_RS13470	COG1609	Transcriptional regulator
HVW38_RS13475	COG2311	Membrane
HVW38_RS13490	COG4771	TonB-dependent receptor
HVW38_RS13495	COG0833	amino acid
HVW38_RS13500	COG0583	DNA-binding transcription factor activity
HVW38_RS13505	COG2855	membrane
HVW38_RS13515	COG1522	sequence-specific DNA binding
HVW38_RS13515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS13520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVW38_RS13530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW38_RS13535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVW38_RS13540	COG2313	pseudouridylate synthase activity
HVW38_RS13545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS13550	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVW38_RS13550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS13550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS13555	COG1105	Belongs to the carbohydrate kinase PfkB family
HVW38_RS13560	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS13560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS13580	COG0246	Mannitol dehydrogenase
HVW38_RS13585	COG0523	cobalamin synthesis protein
HVW38_RS13590	COG0671	phosphoesterase, PA-phosphatase related
HVW38_RS13595	COG0791	NLP P60 protein
HVW38_RS13600	COG2200	EAL domain
HVW38_RS13605	COG4166	transmembrane transport
HVW38_RS13610	COG4174	ABC transporter (Permease)
HVW38_RS13615	COG4239	(ABC) transporter, permease
HVW38_RS13620	COG4172	Belongs to the ABC transporter superfamily
HVW38_RS13630	COG2814	Major facilitator Superfamily
HVW38_RS13635	COG1187	pseudouridine synthase activity
HVW38_RS13640	COG1061	Type III restriction enzyme res subunit
HVW38_RS13650	COG0596	Alpha beta hydrolase
HVW38_RS13665	COG3083	sulfuric ester hydrolase activity
HVW38_RS13685	COG2197	response regulator
HVW38_RS13690	COG3088	subunit of a heme lyase
HVW38_RS13690	COG4235	cytochrome complex assembly
HVW38_RS13695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVW38_RS13700	COG1138	Cytochrome C-type biogenesis protein
HVW38_RS13710	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVW38_RS13715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVW38_RS13720	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVW38_RS13725	COG4133	protoheme IX ABC transporter activity
HVW38_RS13730	COG3005	denitrification pathway
HVW38_RS13735	COG3043	anaerobic respiration
HVW38_RS13740	COG0348	domain, Protein
HVW38_RS13745	COG0437	4 iron, 4 sulfur cluster binding
HVW38_RS13755	COG3062	negative regulation of establishment of protein localization
HVW38_RS13760	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW38_RS13760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW38_RS13770	COG0668	transmembrane transport
HVW38_RS13785	COG4774	siderophore transport
HVW38_RS13795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVW38_RS13805	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVW38_RS13810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVW38_RS13815	COG1199	ATP-dependent helicase activity
HVW38_RS13820	COG0513	Belongs to the DEAD box helicase family
HVW38_RS13825	COG1309	transcriptional regulator
HVW38_RS13835	COG1131	(ABC) transporter
HVW38_RS13840	COG0842	Transport permease protein
HVW38_RS13845	COG0842	Transport permease protein
HVW38_RS13855	COG3568	Endonuclease Exonuclease Phosphatase
HVW38_RS13860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVW38_RS13865	COG0392	lysyltransferase activity
HVW38_RS13870	COG0670	Belongs to the BI1 family
HVW38_RS13885	COG0670	Belongs to the BI1 family
HVW38_RS13890	COG0314	molybdopterin synthase activity
HVW38_RS13895	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVW38_RS13905	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVW38_RS13915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVW38_RS13925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVW38_RS13930	COG2226	methyltransferase
HVW38_RS13945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVW38_RS13950	COG1881	PFAM PEBP family protein
HVW38_RS13955	COG4677	pectinesterase activity
HVW38_RS13965	COG0561	phosphatase activity
HVW38_RS13975	COG4149	molybdate abc transporter
HVW38_RS13980	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVW38_RS13990	COG2005	Transcriptional regulator
HVW38_RS13990	COG3585	molybdate ion transport
HVW38_RS13995	COG1119	ATPase activity
HVW38_RS14000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVW38_RS14005	COG1085	galactose-1-phosphate uridylyltransferase
HVW38_RS14015	COG2017	converts alpha-aldose to the beta-anomer
HVW38_RS14025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVW38_RS14035	COG1230	cation diffusion facilitator family transporter
HVW38_RS14040	COG3201	nicotinamide mononucleotide transporter
HVW38_RS14100	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVW38_RS14105	COG2885	chlorophyll binding
HVW38_RS14115	COG3064	Membrane
HVW38_RS14120	COG0848	biopolymer transport protein
HVW38_RS14125	COG0811	peptide transport
HVW38_RS14130	COG0824	Thioesterase
HVW38_RS14135	COG3790	cyd operon protein YbgE
HVW38_RS14140	COG4890	Cyd operon protein YbgT
HVW38_RS14145	COG1294	oxidase, subunit
HVW38_RS14150	COG1271	oxidase subunit
HVW38_RS14155	COG0383	alpha-mannosidase activity
HVW38_RS14160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS14160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW38_RS14160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS14165	COG2188	Transcriptional regulator
HVW38_RS14170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVW38_RS14180	COG4865	methylaspartate mutase activity
HVW38_RS14185	COG3799	methylaspartate ammonia-lyase activity
HVW38_RS14200	COG1301	dicarboxylic acid transport
HVW38_RS14205	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW38_RS14205	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW38_RS14210	COG0583	DNA-binding transcription factor activity
HVW38_RS14215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVW38_RS14225	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVW38_RS14230	COG0567	Dehydrogenase, E1 component
HVW38_RS14235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVW38_RS14240	COG1053	succinate dehydrogenase
HVW38_RS14245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVW38_RS14250	COG2009	succinate dehydrogenase
HVW38_RS14255	COG0372	Belongs to the citrate synthase family
HVW38_RS14260	COG3539	Fimbrial protein
HVW38_RS14265	COG3188	usher protein
HVW38_RS14270	COG3121	Chaperone
HVW38_RS14275	COG3539	Fimbrial protein
HVW38_RS14280	COG3180	Ammonia monooxygenase
HVW38_RS14305	COG1984	allophanate hydrolase subunit 2
HVW38_RS14310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVW38_RS14315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVW38_RS14325	COG0415	Belongs to the DNA photolyase family
HVW38_RS14330	COG3272	Protein of unknown function (DUF1722)
HVW38_RS14360	COG2205	protein histidine kinase activity
HVW38_RS14365	COG0745	RESPONSE REGULATOR receiver
HVW38_RS14370	COG1982	Orn Lys Arg decarboxylase major
HVW38_RS14375	COG0531	amino acid
HVW38_RS14380	COG0033	Phosphoglucomutase
HVW38_RS14385	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVW38_RS14390	COG0596	Alpha beta hydrolase
HVW38_RS14400	COG0716	FMN binding
HVW38_RS14410	COG0735	belongs to the Fur family
HVW38_RS14430	COG1263	PTS System
HVW38_RS14430	COG2190	(PTS) system
HVW38_RS14430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW38_RS14440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVW38_RS14445	COG1940	carbohydrate kinase activity
HVW38_RS14445	COG1846	Transcriptional regulator
HVW38_RS14450	COG0647	UMP catabolic process
HVW38_RS14455	COG0367	asparagine synthase
HVW38_RS14500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVW38_RS14510	COG1702	phosphate starvation-inducible protein PhoH
HVW38_RS14520	COG4535	Mg2 and Co2 transporter CorC
HVW38_RS14525	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVW38_RS14535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW38_RS14540	COG0765	amino acid transport
HVW38_RS14545	COG0765	amino acid transport
HVW38_RS14550	COG1126	abc transporter atp-binding protein
HVW38_RS14570	COG2888	peptidyl-tyrosine sulfation
HVW38_RS14585	COG1466	dna polymerase III delta subunit
HVW38_RS14595	COG0799	negative regulation of ribosome biogenesis
HVW38_RS14605	COG0768	penicillin binding
HVW38_RS14610	COG0772	Belongs to the SEDS family
HVW38_RS14615	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVW38_RS14620	COG1686	Belongs to the peptidase S11 family
HVW38_RS14645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVW38_RS14665	COG3069	C4-dicarboxylate transmembrane transporter activity
HVW38_RS14670	COG3719	Belongs to the RNase T2 family
HVW38_RS14675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVW38_RS14680	COG0589	response to stress
HVW38_RS14685	COG3634	alkyl hydroperoxide reductase activity
HVW38_RS14690	COG0450	alkyl hydroperoxide reductase
HVW38_RS14695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVW38_RS14700	COG0583	DNA-binding transcription factor activity
HVW38_RS14705	COG3969	phosphoadenosine phosphosulfate
HVW38_RS14710	COG1475	DNA binding
HVW38_RS14715	COG0436	Aminotransferase
HVW38_RS14720	COG0371	Dehydrogenase
HVW38_RS14725	COG2879	small protein
HVW38_RS14730	COG1966	Carbon starvation protein
HVW38_RS14735	COG2050	protein possibly involved in aromatic compounds catabolism
HVW38_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS14745	COG1535	isochorismatase
HVW38_RS14745	COG3433	isochorismatase activity
HVW38_RS14750	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVW38_RS14755	COG1169	isochorismate synthase
HVW38_RS14760	COG4592	Periplasmic binding protein
HVW38_RS14770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVW38_RS14775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVW38_RS14780	COG1120	ATPase activity
HVW38_RS14800	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVW38_RS14800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVW38_RS14805	COG3251	PFAM MbtH domain protein
HVW38_RS14810	COG2382	esterase
HVW38_RS14815	COG4771	TonB-dependent receptor
HVW38_RS14820	COG2977	Belongs to the P-Pant transferase superfamily
HVW38_RS14850	COG2315	Protein conserved in bacteria
HVW38_RS14855	COG0778	Nitroreductase
HVW38_RS14860	COG0668	transmembrane transport
HVW38_RS14865	COG1113	amino acid transport
HVW38_RS14870	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW38_RS14875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW38_RS14880	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW38_RS14885	COG1538	Outer membrane efflux protein
HVW38_RS14890	COG0745	RESPONSE REGULATOR receiver
HVW38_RS14895	COG5002	protein histidine kinase activity
HVW38_RS14930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVW38_RS14940	COG2832	Protein of unknown function (DUF454)
HVW38_RS14945	COG3923	Primosomal replication protein n
HVW38_RS14955	COG1196	nuclear chromosome segregation
HVW38_RS14955	COG3264	Mechanosensitive ion channel
HVW38_RS14960	COG1309	transcriptional regulator
HVW38_RS14965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW38_RS14970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW38_RS14990	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVW38_RS14995	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVW38_RS15005	COG3695	enzyme binding
HVW38_RS15010	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVW38_RS15015	COG1946	Acyl-CoA thioesterase
HVW38_RS15020	COG0004	ammonium transporteR
HVW38_RS15025	COG0347	Belongs to the P(II) protein family
HVW38_RS15030	COG1132	(ABC) transporter
HVW38_RS15035	COG1132	(ABC) transporter
HVW38_RS15040	COG1522	sequence-specific DNA binding
HVW38_RS15050	COG4533	DNA binding
HVW38_RS15060	COG0824	Thioesterase
HVW38_RS15065	COG1555	photosystem II stabilization
HVW38_RS15070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVW38_RS15075	COG0776	regulation of translation
HVW38_RS15080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVW38_RS15100	COG0271	Belongs to the BolA IbaG family
HVW38_RS15105	COG3056	Lipoprotein
HVW38_RS15110	COG2223	nitrite transmembrane transporter activity
HVW38_RS15115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVW38_RS15120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVW38_RS15125	COG1845	cytochrome c oxidase, subunit III
HVW38_RS15130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVW38_RS15145	COG1414	Transcriptional regulator
HVW38_RS15150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVW38_RS15180	COG2814	Major facilitator Superfamily
HVW38_RS15190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVW38_RS15195	COG0693	protein deglycase activity
HVW38_RS15210	COG0142	geranyltranstransferase activity
HVW38_RS15220	COG0667	Aldo Keto reductase
HVW38_RS15225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVW38_RS15245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVW38_RS15245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVW38_RS15255	COG4238	major outer membrane lipoprotein
HVW38_RS15260	COG3248	Nucleoside-binding outer membrane protein
HVW38_RS15270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVW38_RS15275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVW38_RS15280	COG1862	Preprotein translocase
HVW38_RS15300	COG0366	Alpha amylase catalytic
HVW38_RS15305	COG1113	amino acid transport
HVW38_RS15310	COG1114	Component of the transport system for branched-chain amino acids
HVW38_RS15315	COG5002	protein histidine kinase activity
HVW38_RS15325	COG0420	3'-5' exonuclease activity
HVW38_RS15330	COG0419	ATPase involved in DNA repair
HVW38_RS15335	COG1940	carbohydrate kinase activity
HVW38_RS15350	COG4126	flavin adenine dinucleotide binding
HVW38_RS15370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVW38_RS15375	COG3706	GGDEF domain
HVW38_RS15395	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVW38_RS15415	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVW38_RS15420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVW38_RS15425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW38_RS15435	COG0113	porphobilinogen synthase activity
HVW38_RS15440	COG2175	clavaminate synthase activity
HVW38_RS15445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVW38_RS15455	COG4521	taurine ABC transporter
HVW38_RS15460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HVW38_RS15470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVW38_RS15475	COG2079	MmgE PrpD family protein
HVW38_RS15480	COG0372	Belongs to the citrate synthase family
HVW38_RS15485	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVW38_RS15490	COG3829	transcription factor binding
HVW38_RS15500	COG1280	lysine exporter protein (LysE YggA)
HVW38_RS15505	COG3706	GGDEF domain
HVW38_RS15510	COG2186	Transcriptional regulator
HVW38_RS15515	COG1063	alcohol dehydrogenase
HVW38_RS15520	COG2271	Major facilitator Superfamily
HVW38_RS15525	COG2200	EAL domain
HVW38_RS15535	COG2771	luxR family
HVW38_RS15535	COG2200	EAL domain
HVW38_RS15540	COG0454	-acetyltransferase
HVW38_RS15545	COG0656	L-ascorbic acid biosynthetic process
HVW38_RS15550	COG0667	Aldo Keto reductase
HVW38_RS15665	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVW38_RS15670	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVW38_RS15785	COG3772	lysozyme
HVW38_RS15795	COG2207	Transcriptional regulator
HVW38_RS15800	COG3272	Protein of unknown function (DUF1722)
HVW38_RS15935	COG0582	viral genome integration into host DNA
HVW38_RS15955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVW38_RS15975	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVW38_RS15990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVW38_RS15995	COG1690	Belongs to the RtcB family
HVW38_RS16000	COG0454	-acetyltransferase
HVW38_RS16020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVW38_RS16025	COG1074	ATP-dependent DNA helicase activity
HVW38_RS16030	COG1025	Belongs to the peptidase M16 family
HVW38_RS16035	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVW38_RS16040	COG4967	type IV pilus modification protein PilV
HVW38_RS16055	COG2165	general secretion pathway protein
HVW38_RS16085	COG0861	Integral membrane protein TerC family
HVW38_RS16095	COG0667	Aldo Keto reductase
HVW38_RS16120	COG1609	Transcriptional regulator
HVW38_RS16130	COG0583	DNA-binding transcription factor activity
HVW38_RS16135	COG0183	Belongs to the thiolase family
HVW38_RS16140	COG0814	amino acid
HVW38_RS16145	COG2771	luxR family
HVW38_RS16150	COG3710	Transcriptional regulator
HVW38_RS16160	COG1215	transferase activity, transferring glycosyl groups
HVW38_RS16175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVW38_RS16180	COG0402	S-adenosylhomocysteine deaminase activity
HVW38_RS16200	COG1388	LysM domain
HVW38_RS16200	COG1470	cell adhesion involved in biofilm formation
HVW38_RS16215	COG4942	peptidase
HVW38_RS16220	COG0235	Class ii aldolase
HVW38_RS16235	COG1126	abc transporter atp-binding protein
HVW38_RS16240	COG0583	DNA-binding transcription factor activity
HVW38_RS16245	COG2072	flavoprotein involved in K transport
HVW38_RS16260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVW38_RS16265	COG0076	glutamate decarboxylase activity
HVW38_RS16270	COG2066	Belongs to the glutaminase family
HVW38_RS16275	COG2080	2 iron, 2 sulfur cluster binding
HVW38_RS16280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVW38_RS16285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVW38_RS16290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVW38_RS16305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVW38_RS16315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVW38_RS16320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVW38_RS16325	COG4974	Belongs to the 'phage' integrase family
HVW38_RS16330	COG0716	FMN binding
HVW38_RS16340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVW38_RS16350	COG1272	protein, Hemolysin III
HVW38_RS16360	COG2723	6-phospho-beta-galactosidase activity
HVW38_RS16390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVW38_RS16395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVW38_RS16400	COG0006	proline dipeptidase activity
HVW38_RS16420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVW38_RS16430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVW38_RS16445	COG2968	Membrane
HVW38_RS16450	COG1279	arginine transmembrane transporter activity
HVW38_RS16455	COG0668	transmembrane transport
HVW38_RS16460	COG0191	fructose-bisphosphate aldolase activity
HVW38_RS16475	COG1072	(Pantothenic acid kinase))
HVW38_RS16485	COG1494	fructose-1,6-bisphosphatase
HVW38_RS16490	COG1063	alcohol dehydrogenase
HVW38_RS16495	COG2213	PTS system mannitol-specific
HVW38_RS16500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS16505	COG0330	HflC and HflK could
HVW38_RS16510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVW38_RS16515	COG0501	Belongs to the peptidase M48B family
HVW38_RS16525	COG4948	Mandelate Racemase Muconate Lactonizing
HVW38_RS16535	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS16540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVW38_RS16550	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVW38_RS16555	COG1166	arginine decarboxylase activity
HVW38_RS16580	COG2814	Major facilitator Superfamily
HVW38_RS16590	COG2356	endonuclease I
HVW38_RS16595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVW38_RS16600	COG0189	ligase activity
HVW38_RS16615	COG2805	Type II/IV secretion system protein
HVW38_RS16620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVW38_RS16625	COG0762	integral membrane protein
HVW38_RS16640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVW38_RS16645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVW38_RS16650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVW38_RS16665	COG0252	asparaginase activity
HVW38_RS16675	COG3171	Protein conserved in bacteria
HVW38_RS16685	COG1194	a g-specific adenine glycosylase
HVW38_RS16700	COG2211	Major facilitator Superfamily
HVW38_RS16705	COG1982	Orn Lys Arg decarboxylase major
HVW38_RS16710	COG1811	Na channel or pump
HVW38_RS16720	COG0582	viral genome integration into host DNA
HVW38_RS16800	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HVW38_RS16810	COG4584	PFAM Integrase catalytic
HVW38_RS16815	COG1484	DNA-dependent DNA replication
HVW38_RS16835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVW38_RS16840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVW38_RS16945	COG3468	outer membrane autotransporter barrel domain protein
HVW38_RS16950	COG2020	methyltransferase activity
HVW38_RS16975	COG2003	Belongs to the UPF0758 family
HVW38_RS17025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HVW38_RS17045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVW38_RS17050	COG1459	type II secretion system
HVW38_RS17055	COG2165	general secretion pathway protein
HVW38_RS17070	COG4795	General secretion pathway protein
HVW38_RS17085	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HVW38_RS17095	COG0754	glutathionylspermidine amidase activity
HVW38_RS17100	COG2207	Transcriptional regulator
HVW38_RS17105	COG0625	glutathione transferase activity
HVW38_RS17110	COG0298	carbon dioxide binding
HVW38_RS17120	COG1773	rubredoxin
HVW38_RS17125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVW38_RS17130	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVW38_RS17135	COG5557	Pfam Polysulphide reductase, NrfD
HVW38_RS17140	COG0437	4 iron, 4 sulfur cluster binding
HVW38_RS17145	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVW38_RS17160	COG0667	Aldo Keto reductase
HVW38_RS17170	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS17175	COG0848	biopolymer transport protein
HVW38_RS17180	COG0811	peptide transport
HVW38_RS17185	COG0626	cystathionine gamma-synthase activity
HVW38_RS17190	COG0586	Pfam SNARE associated Golgi protein
HVW38_RS17195	COG2207	Transcriptional regulator
HVW38_RS17200	COG1979	alcohol dehydrogenase
HVW38_RS17205	COG0656	L-ascorbic acid biosynthetic process
HVW38_RS17210	COG0471	metal ion transport
HVW38_RS17215	COG4238	major outer membrane lipoprotein
HVW38_RS17220	COG1032	radical SAM domain protein
HVW38_RS17225	COG2186	Transcriptional regulator
HVW38_RS17230	COG0246	Mannitol dehydrogenase
HVW38_RS17235	COG1063	alcohol dehydrogenase
HVW38_RS17240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVW38_RS17265	COG0204	Acyl-transferase
HVW38_RS17270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVW38_RS17275	COG3111	PFAM Bacterial OB fold (BOF) protein
HVW38_RS17280	COG0745	RESPONSE REGULATOR receiver
HVW38_RS17285	COG0642	Histidine kinase
HVW38_RS17290	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVW38_RS17295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVW38_RS17300	COG0187	DNA topoisomerase II activity
HVW38_RS17305	COG3150	esterase
HVW38_RS17310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVW38_RS17315	COG3151	Protein conserved in bacteria
HVW38_RS17320	COG0494	nUDIX hydrolase
HVW38_RS17325	COG1538	Outer membrane efflux protein
HVW38_RS17335	COG0754	glutathionylspermidine amidase activity
HVW38_RS17345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HVW38_RS17355	COG3384	dioxygenase
HVW38_RS17370	COG3539	Fimbrial protein
HVW38_RS17375	COG3188	usher protein
HVW38_RS17380	COG3121	Chaperone
HVW38_RS17385	COG3539	Fimbrial protein
HVW38_RS17405	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVW38_RS17410	COG2268	Band 7 protein
HVW38_RS17440	COG3025	triphosphatase activity
HVW38_RS17445	COG4991	sh3 domain protein
HVW38_RS17460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVW38_RS17475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVW38_RS17480	COG0358	DNA primase activity
HVW38_RS17485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVW38_RS17545	COG3118	belongs to the thioredoxin family
HVW38_RS17555	COG2375	cellular response to nickel ion
HVW38_RS17560	COG1695	Transcriptional regulator
HVW38_RS17565	COG0840	transmembrane signaling receptor activity
HVW38_RS17575	COG0477	Major facilitator Superfamily
HVW38_RS17580	COG3501	Rhs element vgr protein
HVW38_RS17585	COG2186	Transcriptional regulator
HVW38_RS17590	COG0246	Mannitol dehydrogenase
HVW38_RS17600	COG3065	identical protein binding
HVW38_RS17605	COG2197	response regulator
HVW38_RS17610	COG1285	pathogenesis
HVW38_RS17625	COG3247	response to pH
HVW38_RS17630	COG2771	luxR family
HVW38_RS17635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW38_RS17640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW38_RS17645	COG2207	Transcriptional regulator
HVW38_RS17680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVW38_RS17685	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVW38_RS17690	COG1924	4 iron, 4 sulfur cluster binding
HVW38_RS17700	COG1902	pentaerythritol trinitrate reductase activity
HVW38_RS17700	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVW38_RS17705	COG0840	transmembrane signaling receptor activity
HVW38_RS17715	COG4145	pantothenate transmembrane transporter activity
HVW38_RS17725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HVW38_RS17735	COG1846	Transcriptional regulator
HVW38_RS17740	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVW38_RS17745	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS17750	COG3384	dioxygenase
HVW38_RS17760	COG3971	2-oxopent-4-enoate hydratase activity
HVW38_RS17780	COG2368	4-hydroxyphenylacetate
HVW38_RS17785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVW38_RS17790	COG1966	Carbon starvation protein
HVW38_RS17795	COG2879	small protein
HVW38_RS17800	COG0523	cobalamin synthesis protein
HVW38_RS17820	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HVW38_RS17825	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVW38_RS17830	COG0732	type I restriction modification DNA specificity domain
HVW38_RS17840	COG1401	restriction endodeoxyribonuclease activity
HVW38_RS17845	COG4268	DNA restriction-modification system
HVW38_RS17855	COG1196	nuclear chromosome segregation
HVW38_RS17860	COG5457	Domain of unknown function (DUF1127)
HVW38_RS17865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVW38_RS17875	COG2814	Major facilitator Superfamily
HVW38_RS17880	COG2733	membrane
HVW38_RS17910	COG1401	restriction endodeoxyribonuclease activity
HVW38_RS17940	COG1064	alcohol dehydrogenase
HVW38_RS17945	COG0433	COG0433 Predicted ATPase
HVW38_RS17950	COG0701	Predicted permease
HVW38_RS17955	COG0702	epimerase
HVW38_RS17960	COG0693	protein deglycase activity
HVW38_RS17975	COG3153	acetyltransferase
HVW38_RS17980	COG3154	lipid carrier protein
HVW38_RS17985	COG0826	peptidase U32
HVW38_RS17990	COG0826	peptidase U32
HVW38_RS17995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVW38_RS18000	COG3034	peptidoglycan biosynthetic process
HVW38_RS18045	COG0511	ligase activity, forming carbon-carbon bonds
HVW38_RS18070	COG0814	amino acid
HVW38_RS18075	COG0513	Belongs to the DEAD box helicase family
HVW38_RS18115	COG0195	Participates in both transcription termination and antitermination
HVW38_RS18135	COG2194	sulfuric ester hydrolase activity
HVW38_RS18145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVW38_RS18155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVW38_RS18160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVW38_RS18170	COG1534	Rna-binding protein
HVW38_RS18175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVW38_RS18180	COG2027	D-alanyl-D-alanine carboxypeptidase
HVW38_RS18190	COG0697	spore germination
HVW38_RS18205	COG0142	geranyltranstransferase activity
HVW38_RS18210	COG3423	Transcriptional regulator
HVW38_RS18220	COG5007	Belongs to the BolA IbaG family
HVW38_RS18225	COG3113	response to antibiotic
HVW38_RS18230	COG2854	intermembrane phospholipid transfer
HVW38_RS18235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVW38_RS18240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVW38_RS18245	COG1127	ABC transporter
HVW38_RS18250	COG0530	calcium, potassium:sodium antiporter activity
HVW38_RS18255	COG0517	IMP dehydrogenase activity
HVW38_RS18255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVW38_RS18260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVW38_RS18265	COG3117	lipopolysaccharide transmembrane transporter activity
HVW38_RS18270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVW38_RS18275	COG1137	ATPase activity
HVW38_RS18280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVW38_RS18285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVW38_RS18300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS18305	COG0515	serine threonine protein kinase
HVW38_RS18315	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVW38_RS18320	COG5002	protein histidine kinase activity
HVW38_RS18320	COG2198	Histidine kinase
HVW38_RS18320	COG0784	Response regulator, receiver
HVW38_RS18325	COG1242	4 iron, 4 sulfur cluster binding
HVW38_RS18330	COG0070	glutamate synthase
HVW38_RS18330	COG0069	glutamate synthase activity
HVW38_RS18330	COG0067	glutamate synthase
HVW38_RS18335	COG0493	'glutamate synthase
HVW38_RS18340	COG4804	nuclease activity
HVW38_RS18345	COG2731	YhcH YjgK YiaL family protein
HVW38_RS18375	COG2969	positive regulation of protein catabolic process
HVW38_RS18380	COG0625	glutathione transferase activity
HVW38_RS18395	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVW38_RS18400	COG3105	Protein conserved in bacteria
HVW38_RS18405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVW38_RS18410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVW38_RS18420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW38_RS18425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW38_RS18430	COG0471	metal ion transport
HVW38_RS18440	COG1802	Transcriptional regulator
HVW38_RS18460	COG4771	TonB-dependent receptor
HVW38_RS18465	COG2732	(Barnase) inhibitor
HVW38_RS18485	COG0583	DNA-binding transcription factor activity
HVW38_RS18490	COG0312	modulator of DNA gyrase
HVW38_RS18495	COG3164	Protein of unknown function
HVW38_RS18500	COG1530	ribonuclease E activity
HVW38_RS18510	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVW38_RS18515	COG1792	Involved in formation and maintenance of cell shape
HVW38_RS18520	COG1077	Cell shape determining protein MreB Mrl
HVW38_RS18525	COG2199	diguanylate cyclase activity
HVW38_RS18525	COG2200	EAL domain
HVW38_RS18530	COG0604	alcohol dehydrogenase
HVW38_RS18545	COG0511	ligase activity, forming carbon-carbon bonds
HVW38_RS18550	COG0439	Biotin carboxylase
HVW38_RS18555	COG3924	membrane
HVW38_RS18560	COG4145	pantothenate transmembrane transporter activity
HVW38_RS18570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVW38_RS18580	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVW38_RS18590	COG1309	transcriptional regulator
HVW38_RS18595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW38_RS18600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW38_RS18610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW38_RS18615	COG4597	amino acid ABC transporter
HVW38_RS18620	COG0765	amino acid transport
HVW38_RS18625	COG1126	abc transporter atp-binding protein
HVW38_RS18665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVW38_RS18685	COG0551	DNA topoisomerase type I activity
HVW38_RS18695	COG0758	DNA mediated transformation
HVW38_RS18715	COG0569	domain protein
HVW38_RS18725	COG3036	rescue of stalled ribosome
HVW38_RS18730	COG0789	Transcriptional regulator
HVW38_RS18770	COG0201	protein transport
HVW38_RS18860	COG0089	rRNA binding
HVW38_RS18875	COG0051	transcription antitermination factor activity, RNA binding
HVW38_RS18930	COG2964	Protein conserved in bacteria
HVW38_RS18935	COG0545	Peptidyl-prolyl cis-trans isomerase
HVW38_RS18950	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVW38_RS18965	COG0488	(ABC) transporter
HVW38_RS18970	COG0429	hydrolase of the alpha beta-hydrolase fold
HVW38_RS18980	COG3954	Phosphoribulokinase
HVW38_RS18985	COG1765	OsmC-like protein
HVW38_RS18990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW38_RS18995	COG1289	transmembrane transporter activity
HVW38_RS19000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVW38_RS19005	COG0512	Glutamine amidotransferase of anthranilate synthase
HVW38_RS19010	COG2184	nucleotidyltransferase activity
HVW38_RS19025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVW38_RS19030	COG2146	nitrite reductase [NAD(P)H] activity
HVW38_RS19035	COG2116	formate transmembrane transporter activity
HVW38_RS19050	COG0626	cystathionine gamma-synthase activity
HVW38_RS19065	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVW38_RS19070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVW38_RS19075	COG3457	Alanine racemase
HVW38_RS19085	COG2188	Transcriptional regulator
HVW38_RS19090	COG0180	Tryptophanyl-tRNA synthetase
HVW38_RS19100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVW38_RS19105	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVW38_RS19110	COG3266	domain, Protein
HVW38_RS19125	COG4796	Type ii and iii secretion system protein
HVW38_RS19140	COG3166	PFAM Fimbrial assembly family protein
HVW38_RS19145	COG4972	Pilus assembly protein
HVW38_RS19150	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVW38_RS19155	COG0494	nUDIX hydrolase
HVW38_RS19165	COG1011	Hydrolase
HVW38_RS19170	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVW38_RS19180	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVW38_RS19215	COG2205	protein histidine kinase activity
HVW38_RS19220	COG0745	RESPONSE REGULATOR receiver
HVW38_RS19225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVW38_RS19230	COG2183	response to ionizing radiation
HVW38_RS19235	COG1918	ferrous iron import across plasma membrane
HVW38_RS19240	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVW38_RS19250	COG5464	transposase or invertase
HVW38_RS19270	COG2610	gluconate transmembrane transporter activity
HVW38_RS19280	COG1640	4-alpha-glucanotransferase
HVW38_RS19285	COG0058	SHG alpha-glucan phosphorylase activity
HVW38_RS19300	COG1690	Belongs to the RtcB family
HVW38_RS19305	COG4650	regulator
HVW38_RS19310	COG1349	DNA-binding transcription factor activity
HVW38_RS19325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVW38_RS19350	COG3121	Chaperone
HVW38_RS19360	COG3539	Fimbrial protein
HVW38_RS19370	COG3121	Chaperone
HVW38_RS19380	COG0058	SHG alpha-glucan phosphorylase activity
HVW38_RS19405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVW38_RS19410	COG2095	MarC family integral membrane protein
HVW38_RS19415	COG2610	gluconate transmembrane transporter activity
HVW38_RS19420	COG3265	gluconokinase activity
HVW38_RS19425	COG1609	Transcriptional regulator
HVW38_RS19430	COG1741	Belongs to the pirin family
HVW38_RS19435	COG0673	inositol 2-dehydrogenase activity
HVW38_RS19440	COG1247	-acetyltransferase
HVW38_RS19450	COG0405	Gamma-glutamyltransferase
HVW38_RS19460	COG0584	glycerophosphoryl diester phosphodiesterase
HVW38_RS19475	COG1175	transmembrane transport
HVW38_RS19480	COG1653	transport
HVW38_RS19490	COG0410	ABC transporter
HVW38_RS19495	COG0411	ABC transporter
HVW38_RS19500	COG4177	L-phenylalanine transmembrane transporter activity
HVW38_RS19505	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVW38_RS19510	COG0683	leucine binding
HVW38_RS19515	COG0456	acetyltransferase
HVW38_RS19520	COG0683	leucine binding
HVW38_RS19525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVW38_RS19530	COG2177	Part of the ABC transporter FtsEX involved in
HVW38_RS19535	COG2884	Cell division ATP-binding protein ftsE
HVW38_RS19540	COG0552	protein localization to endoplasmic reticulum
HVW38_RS19545	COG0742	ribosomal rna small subunit methyltransferase
HVW38_RS19550	COG3776	membrane
HVW38_RS19560	COG3714	YhhN family
HVW38_RS19575	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVW38_RS19590	COG0628	permease
HVW38_RS19610	COG0204	Acyl-transferase
HVW38_RS19620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVW38_RS19640	COG1216	Glycosyl transferase, family 2
HVW38_RS19665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW38_RS19675	COG1028	Short-chain dehydrogenase reductase Sdr
HVW38_RS19680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW38_RS19685	COG2091	lysine biosynthetic process via aminoadipic acid
HVW38_RS19695	COG0842	Transport permease protein
HVW38_RS19700	COG0842	Transport permease protein
HVW38_RS19700	COG1129	ABC transporter
HVW38_RS19705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW38_RS19730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW38_RS19735	COG2081	HI0933 family
HVW38_RS19740	COG0306	phosphate transporter
HVW38_RS19750	COG0589	response to stress
HVW38_RS19755	COG3104	oligopeptide transport
HVW38_RS19770	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVW38_RS19780	COG0584	glycerophosphoryl diester phosphodiesterase
HVW38_RS19785	COG1940	carbohydrate kinase activity
HVW38_RS19795	COG0339	signal peptide processing
HVW38_RS19800	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVW38_RS19805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVW38_RS19820	COG0640	Transcriptional regulator
HVW38_RS19825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVW38_RS19830	COG1393	Belongs to the ArsC family
HVW38_RS19850	COG2197	response regulator
HVW38_RS19855	COG1295	ribonuclease BN
HVW38_RS19860	COG0477	Major facilitator Superfamily
HVW38_RS19865	COG2982	Protein involved in outer membrane biogenesis
HVW38_RS19870	COG2200	EAL domain
HVW38_RS19875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS19890	COG0612	Peptidase, M16
HVW38_RS19900	COG2200	EAL domain
HVW38_RS19900	COG2199	diguanylate cyclase activity
HVW38_RS19905	COG3118	belongs to the thioredoxin family
HVW38_RS19905	COG0457	Tetratricopeptide repeat
HVW38_RS19910	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVW38_RS19915	COG1215	transferase activity, transferring glycosyl groups
HVW38_RS19920	COG1215	transferase activity, transferring glycosyl groups
HVW38_RS19945	COG2194	sulfuric ester hydrolase activity
HVW38_RS19970	COG0814	amino acid
HVW38_RS19980	COG4608	Belongs to the ABC transporter superfamily
HVW38_RS19985	COG0444	Belongs to the ABC transporter superfamily
HVW38_RS19990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVW38_RS19995	COG0601	transmembrane transport
HVW38_RS20000	COG0747	negative chemotaxis
HVW38_RS20015	COG2194	sulfuric ester hydrolase activity
HVW38_RS20020	COG2223	nitrite transmembrane transporter activity
HVW38_RS20025	COG5571	outer membrane autotransporter
HVW38_RS20030	COG2818	Glycosylase
HVW38_RS20035	COG0456	acetyltransferase
HVW38_RS20040	COG0243	molybdopterin cofactor binding
HVW38_RS20045	COG2885	chlorophyll binding
HVW38_RS20050	COG1609	Transcriptional regulator
HVW38_RS20060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS20080	COG2814	Major facilitator Superfamily
HVW38_RS20085	COG2944	sequence-specific DNA binding
HVW38_RS20090	COG1278	Cold shock
HVW38_RS20120	COG3274	enterobacterial common antigen metabolic process
HVW38_RS20125	COG4682	membrane
HVW38_RS20130	COG1070	Carbohydrate kinase
HVW38_RS20140	COG1609	Transcriptional regulator
HVW38_RS20140	COG2207	Transcriptional regulator
HVW38_RS20145	COG2992	FlgJ-related protein
HVW38_RS20150	COG0366	Alpha amylase catalytic
HVW38_RS20155	COG3977	Valine--pyruvate aminotransferase
HVW38_RS20160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW38_RS20165	COG1414	Transcriptional regulator
HVW38_RS20175	COG2731	YhcH YjgK YiaL family protein
HVW38_RS20180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVW38_RS20185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVW38_RS20190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVW38_RS20195	COG1070	Carbohydrate kinase
HVW38_RS20200	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HVW38_RS20205	COG3623	hexulose-6-phosphate isomerase
HVW38_RS20210	COG0235	Class ii aldolase
HVW38_RS20215	COG1012	belongs to the aldehyde dehydrogenase family
HVW38_RS20220	COG1454	alcohol dehydrogenase
HVW38_RS20225	COG3276	selenocysteine insertion sequence binding
HVW38_RS20235	COG0625	glutathione transferase activity
HVW38_RS20240	COG1566	PFAM secretion protein HlyD family protein
HVW38_RS20250	COG2213	PTS system mannitol-specific
HVW38_RS20250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS20260	COG3722	fumarate hydratase activity
HVW38_RS20290	COG5295	Hep Hag repeat protein
HVW38_RS20300	COG2186	Transcriptional regulator
HVW38_RS20310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVW38_RS20315	COG1045	serine acetyltransferase
HVW38_RS20330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVW38_RS20335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVW38_RS20345	COG4942	peptidase
HVW38_RS20350	COG2861	carbohydrate metabolic process
HVW38_RS20355	COG1216	Glycosyl transferase, family 2
HVW38_RS20360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVW38_RS20365	COG3078	GTPase activator activity
HVW38_RS20380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVW38_RS20380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVW38_RS20385	COG0204	Acyl-transferase
HVW38_RS20390	COG5339	Protein conserved in bacteria
HVW38_RS20395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVW38_RS20400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVW38_RS20405	COG3084	Protein conserved in bacteria
HVW38_RS20410	COG0746	molybdenum cofactor guanylyltransferase activity
HVW38_RS20415	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVW38_RS20445	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVW38_RS20450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVW38_RS20455	COG1739	Uncharacterized protein family UPF0029
HVW38_RS20480	COG0543	2 iron, 2 sulfur cluster binding
HVW38_RS20485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVW38_RS20490	COG0250	Participates in transcription elongation, termination and antitermination
HVW38_RS20500	COG0805	protein transport
HVW38_RS20510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVW38_RS20520	COG3165	ubiquinone biosynthetic process from chorismate
HVW38_RS20530	COG1322	Protein conserved in bacteria
HVW38_RS20535	COG1414	Transcriptional regulator
HVW38_RS20540	COG3734	2-keto-3-deoxy-galactonokinase
HVW38_RS20545	COG0800	Aldolase
HVW38_RS20565	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVW38_RS20570	COG0412	Dienelactone hydrolase
HVW38_RS20575	COG2188	Transcriptional regulator
HVW38_RS20595	COG0583	DNA-binding transcription factor activity
HVW38_RS20610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HVW38_RS20615	COG2828	Protein conserved in bacteria
HVW38_RS20620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVW38_RS20625	COG0473	3-isopropylmalate dehydrogenase activity
HVW38_RS20645	COG0583	DNA-binding transcription factor activity
HVW38_RS20650	COG0697	spore germination
HVW38_RS20655	COG0561	phosphatase activity
HVW38_RS20660	COG2267	carboxylic ester hydrolase activity
HVW38_RS20665	COG1280	lysine exporter protein (LysE YggA)
HVW38_RS20675	COG1280	lysine exporter protein (LysE YggA)
HVW38_RS20680	COG0514	ATP-dependent DNA helicase (RecQ)
HVW38_RS20690	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVW38_RS20695	COG2050	protein possibly involved in aromatic compounds catabolism
HVW38_RS20700	COG2962	Rard protein
HVW38_RS20705	COG0598	Magnesium transport protein CorA
HVW38_RS20710	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HVW38_RS20715	COG0210	DNA helicase
HVW38_RS20720	COG1011	Hydrolase
HVW38_RS20730	COG3159	Protein conserved in bacteria
HVW38_RS20740	COG5567	small periplasmic lipoprotein
HVW38_RS20755	COG3072	Adenylate cyclase
HVW38_RS20770	COG2959	enzyme of heme biosynthesis
HVW38_RS20775	COG3071	HemY protein
HVW38_RS20780	COG3119	arylsulfatase activity
HVW38_RS20785	COG0641	radical SAM
HVW38_RS20810	COG1113	amino acid transport
HVW38_RS20830	COG2244	polysaccharide biosynthetic process
HVW38_RS20835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVW38_RS20840	COG0456	acetyltransferase
HVW38_RS20845	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVW38_RS20850	COG1088	dTDP-glucose 4,6-dehydratase activity
HVW38_RS20855	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVW38_RS20860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVW38_RS20865	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVW38_RS20870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVW38_RS20875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVW38_RS20885	COG3118	belongs to the thioredoxin family
HVW38_RS20900	COG0210	DNA helicase
HVW38_RS20905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVW38_RS20915	COG0583	DNA-binding transcription factor activity
HVW38_RS20920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVW38_RS20930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVW38_RS20935	COG3978	acetolactate synthase activity
HVW38_RS20955	COG0606	chelatase, subunit chli
HVW38_RS20960	COG3085	chromosome segregation
HVW38_RS21000	COG2186	Transcriptional regulator
HVW38_RS21005	COG1609	Transcriptional regulator
HVW38_RS21010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW38_RS21015	COG1879	ABC-type sugar transport system periplasmic component
HVW38_RS21020	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW38_RS21025	COG1129	ABC transporter
HVW38_RS21055	COG1522	sequence-specific DNA binding
HVW38_RS21060	COG0716	FMN binding
HVW38_RS21075	COG3312	ion transport
HVW38_RS21135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVW38_RS21140	COG0573	inorganic phosphate transmembrane transporter activity
HVW38_RS21145	COG0581	inorganic phosphate transmembrane transporter activity
HVW38_RS21150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVW38_RS21155	COG0704	Plays a role in the regulation of phosphate uptake
HVW38_RS21160	COG3711	transcriptional antiterminator
HVW38_RS21165	COG2190	(PTS) system
HVW38_RS21165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW38_RS21165	COG1263	PTS System
HVW38_RS21170	COG2723	6-phospho-beta-galactosidase activity
HVW38_RS21180	COG2382	esterase
HVW38_RS21190	COG3196	Protein conserved in bacteria
HVW38_RS21200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW38_RS21205	COG2252	PERMEase
HVW38_RS21215	COG0431	NADPH-dependent FMN reductase
HVW38_RS21220	COG2091	lysine biosynthetic process via aminoadipic acid
HVW38_RS21235	COG0814	amino acid
HVW38_RS21285	COG0592	DNA-directed DNA polymerase activity
HVW38_RS21295	COG0187	DNA topoisomerase II activity
HVW38_RS21300	COG3753	Protein conserved in bacteria
HVW38_RS21305	COG0561	phosphatase activity
HVW38_RS21315	COG2186	Transcriptional regulator
HVW38_RS21320	COG3734	2-keto-3-deoxy-galactonokinase
HVW38_RS21325	COG0800	Aldolase
HVW38_RS21335	COG2271	Major facilitator Superfamily
HVW38_RS21345	COG0823	Involved in the tonB-independent uptake of proteins
HVW38_RS21350	COG5645	(Lipo)protein
HVW38_RS21370	COG2188	Transcriptional regulator
HVW38_RS21390	COG2149	membrane
HVW38_RS21400	COG0641	radical SAM
HVW38_RS21410	COG2610	gluconate transmembrane transporter activity
HVW38_RS21415	COG0583	DNA-binding transcription factor activity
HVW38_RS21420	COG2814	Major facilitator Superfamily
HVW38_RS21435	COG0028	Belongs to the TPP enzyme family
HVW38_RS21440	COG0440	acetolactate synthase activity
HVW38_RS21445	COG2197	response regulator
HVW38_RS21455	COG2271	Major facilitator Superfamily
HVW38_RS21460	COG2271	Major facilitator Superfamily
HVW38_RS21480	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVW38_RS21485	COG2723	6-phospho-beta-galactosidase activity
HVW38_RS21490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVW38_RS21500	COG1609	Transcriptional regulator
HVW38_RS21510	COG0697	spore germination
HVW38_RS21530	COG2211	Major facilitator Superfamily
HVW38_RS21535	COG1501	Belongs to the glycosyl hydrolase 31 family
HVW38_RS21540	COG2982	Protein involved in outer membrane biogenesis
HVW38_RS21545	COG2233	PERMEase
HVW38_RS21550	COG0786	glutamate:sodium symporter activity
HVW38_RS21560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVW38_RS21565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVW38_RS21570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVW38_RS21580	COG0194	GDP metabolic process
HVW38_RS21590	COG2860	membrane
HVW38_RS21595	COG1561	YicC-like family, N-terminal region
HVW38_RS21625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVW38_RS21655	COG1519	Transferase
HVW38_RS21660	COG0859	PFAM glycosyl transferase family 9
HVW38_RS21665	COG0438	transferase activity, transferring glycosyl groups
HVW38_RS21670	COG0515	serine threonine protein kinase
HVW38_RS21675	COG4641	Protein conserved in bacteria
HVW38_RS21675	COG0438	transferase activity, transferring glycosyl groups
HVW38_RS21680	COG0438	transferase activity, transferring glycosyl groups
HVW38_RS21685	COG1442	glycosyl transferase family 8
HVW38_RS21690	COG1442	glycosyl transferase family 8
HVW38_RS21695	COG3642	lipopolysaccharide core region biosynthetic process
HVW38_RS21705	COG0859	PFAM glycosyl transferase family 9
HVW38_RS21710	COG3307	-O-antigen
HVW38_RS21715	COG0859	PFAM glycosyl transferase family 9
HVW38_RS21720	COG0859	PFAM glycosyl transferase family 9
HVW38_RS21730	COG0156	8-amino-7-oxononanoate synthase activity
HVW38_RS21745	COG2204	response regulator
HVW38_RS21750	COG3852	Histidine kinase
HVW38_RS21755	COG0174	glutamine synthetase
HVW38_RS21765	COG0561	phosphatase activity
HVW38_RS21775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVW38_RS21795	COG1011	Hydrolase
HVW38_RS21810	COG0456	acetyltransferase
HVW38_RS21830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVW38_RS21845	COG2864	formate dehydrogenase
HVW38_RS21850	COG0437	4 iron, 4 sulfur cluster binding
HVW38_RS21865	COG0326	Molecular chaperone. Has ATPase activity
HVW38_RS21885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS21885	COG3711	transcriptional antiterminator
HVW38_RS21890	COG1363	Peptidase, m42
HVW38_RS21900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW38_RS21910	COG1454	alcohol dehydrogenase
HVW38_RS21945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVW38_RS21950	COG2258	MOSC domain
HVW38_RS21955	COG2205	protein histidine kinase activity
HVW38_RS21960	COG0745	RESPONSE REGULATOR receiver
HVW38_RS21965	COG3678	ATP-independent chaperone mediated protein folding
HVW38_RS21970	COG4974	Belongs to the 'phage' integrase family
HVW38_RS22030	COG4372	Transposase
HVW38_RS22035	COG3436	PFAM IS66 Orf2 family protein
HVW38_RS22050	COG1484	DNA-dependent DNA replication
HVW38_RS22055	COG4584	PFAM Integrase catalytic
HVW38_RS22115	COG3547	Transposase (IS116 IS110 IS902 family)
HVW38_RS22120	COG3328	transposase activity
HVW38_RS22135	COG3436	PFAM IS66 Orf2 family protein
HVW38_RS22140	COG4372	Transposase
HVW38_RS22200	COG2002	toxin-antitoxin pair type II binding
HVW38_RS22210	COG5290	Psort location Cytoplasmic, score
HVW38_RS22340	COG1475	DNA binding
HVW38_RS22535	COG2805	Type II/IV secretion system protein
HVW38_RS22580	COG0741	lytic transglycosylase activity
HVW38_RS22595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB