locus-tag class description HVY52_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVY52_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY52_RS00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVY52_RS00030 ENOG410667J hydrolase HVY52_RS00035 ENOG410657R replicase EC 2.7 HVY52_RS00040 ENOG4105EMF GntR family transcriptional regulator HVY52_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVY52_RS00050 ENOG4108RTU Aldolase HVY52_RS00060 ENOG4105DJB Major Facilitator Superfamily HVY52_RS00070 ENOG4105D99 atp gtp-binding protein HVY52_RS00075 ENOG4105R2A (LipO)protein HVY52_RS00085 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HVY52_RS00090 ENOG4105D0C transport protein HVY52_RS00095 ENOG4105FDP GntR family transcriptional regulator HVY52_RS00100 ENOG4105CI1 PTS System HVY52_RS00105 ENOG4105F8D glycoside hydrolase family 4 HVY52_RS00110 ENOG4105VG5 Membrane HVY52_RS00115 ENOG4105JP4 Inner membrane protein yidG HVY52_RS00120 ENOG4105J13 transcriptional regulator HVY52_RS00135 ENOG4105W8I Transcriptional regulator HVY52_RS00140 ENOG4105E5M Multidrug resistance protein D HVY52_RS00155 ENOG4105C7K acetolactate synthase HVY52_RS00160 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVY52_RS00165 ENOG4108KX4 response regulator HVY52_RS00170 ENOG4105BZU Histidine kinase HVY52_RS00175 ENOG4105CXY transporter HVY52_RS00180 ENOG4105CXY transporter HVY52_RS00190 ENOG4108SAJ Protein of unknown function (DUF1198) HVY52_RS00200 ENOG4105VCP PTS System HVY52_RS00205 ENOG4105CS2 ec 3.2.1.21 HVY52_RS00210 ENOG4105CK1 PTS System HVY52_RS00220 ENOG4105ETE Transcriptional regulator (LacI family HVY52_RS00225 ENOG4105T8A Uncharacterized protein YicS HVY52_RS00230 ENOG4108UZ3 Transporter HVY52_RS00250 ENOG4105CT4 transporter HVY52_RS00255 ENOG4105CJQ hydrolase, family 31 HVY52_RS00260 ENOG4105JV1 AsmA family HVY52_RS00265 ENOG4105C2W permease HVY52_RS00270 ENOG4105D6U Sodium Glutamate Symporter HVY52_RS00280 ENOG4105CB5 ATP-dependent DNA helicase recG HVY52_RS00285 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVY52_RS00290 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY52_RS00300 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVY52_RS00310 ENOG4105EN6 Membrane HVY52_RS00315 ENOG4105DSJ YicC domain protein HVY52_RS00330 ENOG4107RRE RNA-directed DNA polymerase HVY52_RS00340 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVY52_RS00345 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVY52_RS00355 ENOG4105KDC 50s ribosomal protein l28 HVY52_RS00375 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVY52_RS00380 ENOG4105DKP glycosyl transferase, family 9 HVY52_RS00385 ENOG4107RJ7 Glycosyl transferase (Group 1 HVY52_RS00390 ENOG4107543 (lipo)polysaccharide HVY52_RS00395 ENOG410650X lipopolysaccharide core region biosynthetic process HVY52_RS00400 ENOG4107XU6 Glycosyl transferase (Group 1 HVY52_RS00405 ENOG4106AH0 Glycosyl Transferase HVY52_RS00410 ENOG4105X1N Glycosyl transferase family 8 HVY52_RS00415 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVY52_RS00420 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVY52_RS00425 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HVY52_RS00430 ENOG4108FRV O-antigen ligase HVY52_RS00435 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVY52_RS00440 ENOG4105XA0 heptosyltransferase ii HVY52_RS00450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVY52_RS00460 ENOG4106FIY HVY52_RS00465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY52_RS00470 ENOG4105CUX Signal transduction histidine kinase HVY52_RS00475 ENOG4105C5F glutamine synthetase HVY52_RS00480 ENOG4105CI3 gtp-binding protein typa HVY52_RS00485 ENOG4108K4B hydrolase HVY52_RS00495 ENOG4105CSA Coproporphyrinogen iii oxidase HVY52_RS00515 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVY52_RS00530 ENOG4105SUU thioesterase domain HVY52_RS00560 ENOG4108MG3 formate dehydrogenase HVY52_RS00565 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY52_RS00580 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HVY52_RS00590 ENOG4108V87 frv operon regulatory protein HVY52_RS00600 ENOG4106C3V frv operon regulatory protein HVY52_RS00605 ENOG4105CN9 Peptidase m42 family protein HVY52_RS00610 ENOG4105DM4 PTS System HVY52_RS00615 ENOG41064BA PTS system, fructose-specific, IIA component HVY52_RS00625 ENOG4105C0A alcohol dehydrogenase HVY52_RS00660 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY52_RS00665 ENOG4108RPX mosc domain containing protein HVY52_RS00670 ENOG4105E0F Histidine kinase HVY52_RS00675 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY52_RS00680 ENOG4105FMW periplasmic HVY52_RS00695 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVY52_RS00710 ENOG4105EBK exported protein HVY52_RS00715 ENOG4108VTS Membrane HVY52_RS00720 ENOG41065TG regulatoR HVY52_RS00730 ENOG4105DP0 ferredoxin-NADP reductase HVY52_RS00735 ENOG4105CBT Fructose-1,6-bisphosphatase HVY52_RS00745 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY52_RS00760 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVY52_RS00775 ENOG41063M6 Cell Division Protein HVY52_RS00780 ENOG4105ETE Transcriptional regulator (LacI family HVY52_RS00785 ENOG4105C25 Primosomal protein n' HVY52_RS00800 ENOG4107S01 Repressor protein MetJ HVY52_RS00810 ENOG4105C28 cystathionine HVY52_RS00815 ENOG4105CFH Aspartokinase HVY52_RS00825 ENOG4105CGH 5'-nucleotidase HVY52_RS00830 ENOG4105SYT Methylenetetrahydrofolate reductase HVY52_RS00840 ENOG4108Q5Y Membrane HVY52_RS00845 ENOG4108XC3 NADH ubiquinone oxidoreductase HVY52_RS00850 ENOG4105DCT glycerol dehydrogenase HVY52_RS00855 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY52_RS00860 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY52_RS00865 ENOG4105DM4 PTS System HVY52_RS00870 ENOG4108YRF PTS System HVY52_RS00880 ENOG4108AHH pyruvate formate lyase II activase HVY52_RS00885 ENOG4108XCZ PTS System HVY52_RS00890 ENOG4106R3P AraC family transcriptional regulator HVY52_RS00895 ENOG4105DIJ Phosphoethanolamine transferase HVY52_RS00910 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVY52_RS00925 ENOG4105C5Q Transcriptional regulator HVY52_RS00935 ENOG4105CH2 amidohydrolase HVY52_RS00945 ENOG4105EJ2 Transcriptional regulator HVY52_RS00950 ENOG4108Y73 Membrane HVY52_RS00990 ENOG4105D4A Cell wall formation (By similarity) HVY52_RS00995 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVY52_RS01030 ENOG4105PM1 preprotein translocase subunit SecE HVY52_RS01035 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVY52_RS01070 ENOG4105D41 biosynthesis protein thiH HVY52_RS01080 ENOG4105WHD thiamine biosynthesis protein ThiS HVY52_RS01085 ENOG4105D06 uba thif-type nad fad binding protein HVY52_RS01120 ENOG4105R2J Conserved Protein HVY52_RS01130 ENOG4108T8B Protein of unknown function (DUF1481) HVY52_RS01135 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVY52_RS01140 ENOG4105BZU Histidine kinase HVY52_RS01145 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY52_RS01150 ENOG4105C12 Phosphoribosylglycinamide synthetase HVY52_RS01180 ENOG4105K5X acetyltransferase HVY52_RS01190 ENOG4107QP3 malate synthase g HVY52_RS01195 ENOG4108I9X Isocitrate lyase HVY52_RS01210 ENOG41069M3 Transcriptional regulator HVY52_RS01215 ENOG4105C3R Methionine synthase HVY52_RS01230 ENOG4105EAM Na Pi-cotransporter HVY52_RS01235 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVY52_RS01240 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY52_RS01245 ENOG4105F3R pts system mannose fructose sorbose family iid HVY52_RS01250 ENOG4105ETZ PTS System HVY52_RS01255 ENOG4105KPI PTS system sorbose subfamily IIB component HVY52_RS01260 ENOG4108XCU pts system HVY52_RS01265 ENOG4105CHR reductase HVY52_RS01270 ENOG4105DKT Transcriptional regulator HVY52_RS01275 ENOG4105FE9 pseudouridine synthase HVY52_RS01280 ENOG4108ZR5 Conserved Protein HVY52_RS01290 ENOG410756H nucleotidyltransferase HVY52_RS01310 ENOG410685N tail fiber protein HVY52_RS01390 ENOG4107SC1 transglycosylase HVY52_RS01405 ENOG4108WZA zeta toxin HVY52_RS01410 ENOG4105CFH Aspartokinase HVY52_RS01415 ENOG4107QP8 phosphohexose isomerase HVY52_RS01425 ENOG4108MDC (LipO)protein HVY52_RS01430 ENOG4108Q9C Periplasmic Protein HVY52_RS01435 ENOG4105E3R (LipO)protein HVY52_RS01445 ENOG4107QNK )-transporter HVY52_RS01450 ENOG4105EG2 ABC transporter, permease HVY52_RS01455 ENOG4105D56 permease protein HVY52_RS01460 ENOG4107FKK extracellular solute-binding protein family 1 HVY52_RS01465 ENOG4108IJ9 (ABC) transporter HVY52_RS01475 ENOG4107W52 maltose operon periplasmic protein HVY52_RS01495 ENOG41080IJ Diacylglycerol kinase HVY52_RS01505 ENOG4107R73 Mate efflux family protein HVY52_RS01510 ENOG4105VDW Csbd family HVY52_RS01515 ENOG4105MYN Zinc uptake regulation protein HVY52_RS01520 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY52_RS01525 ENOG4105P4Z Phage shock protein G HVY52_RS01530 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVY52_RS01535 ENOG4105CDU Replicative dna helicase HVY52_RS01545 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY52_RS01550 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY52_RS01555 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVY52_RS01560 ENOG4105CGF Aromatic amino acid aminotransferase HVY52_RS01565 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVY52_RS01570 ENOG4105C7S Dehydrogenase HVY52_RS01575 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY52_RS01580 ENOG4105CMV Succinyl-CoA synthetase subunit beta HVY52_RS01585 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVY52_RS01590 ENOG4107QPK )-transporter HVY52_RS01595 ENOG4105DG4 malate L-lactate dehydrogenase HVY52_RS01600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY52_RS01605 ENOG4105CQZ Histidine kinase HVY52_RS01610 ENOG4105F0S class B acid phosphatase HVY52_RS01615 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVY52_RS01620 ENOG4105MSB protein, conserved in bacteria HVY52_RS01625 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVY52_RS01630 ENOG4108UUM single-stranded DNA-binding protein HVY52_RS01635 ENOG4105PMV Membrane HVY52_RS01640 ENOG4108W3Q Transcriptional regulator HVY52_RS01645 ENOG4108Z4X TRANSCRIPTIONal HVY52_RS01650 ENOG4105C7N Xanthine uracil vitamin C permease HVY52_RS01655 ENOG4105EEQ Na H antiporter HVY52_RS01660 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVY52_RS01665 ENOG4108F5E vimentin HVY52_RS01670 ENOG4108YIV HVY52_RS01675 ENOG4105CSH Transporter HVY52_RS01680 ENOG4105ECM Sensor protein basS pmrB HVY52_RS01685 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY52_RS01690 ENOG4105DIJ Phosphoethanolamine transferase HVY52_RS01695 ENOG4106ZGR Transcriptional regulator HVY52_RS01700 ENOG4108R5S membrane HVY52_RS01705 ENOG4107GFK fumarate HVY52_RS01710 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY52_RS01715 ENOG4108MRH transcriptional regulatory protein HVY52_RS01720 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY52_RS01725 ENOG4107QY8 reductase HVY52_RS01730 ENOG4105QAX Iron-sulfur HVY52_RS01735 ENOG4107KGK dmso reductase anchor subunit HVY52_RS01740 ENOG4108NEM leader-binding protein dmsD HVY52_RS01760 ENOG4108SIC Transcriptional regulator HVY52_RS01765 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVY52_RS01775 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY52_RS01780 ENOG4108IJ0 Aspartate ammonia-lyase HVY52_RS01785 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVY52_RS01790 ENOG4105DVH amino acid HVY52_RS01805 ENOG4108ZVF (LipO)protein HVY52_RS01810 ENOG4105MTB Uncharacterized protein YjeJ HVY52_RS01815 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVY52_RS01825 ENOG4107PEH Entericidin EcnA/B family HVY52_RS01830 ENOG4106BSU Entericidin B HVY52_RS01835 ENOG4105KPY Small multidrug resistance protein HVY52_RS01840 ENOG4105QNF Outer membrane lipoprotein HVY52_RS01845 ENOG41066YJ Beta-lactamase HVY52_RS01860 ENOG4105E33 succinate dehydrogenase HVY52_RS01865 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY52_RS01875 ENOG4107SC7 Inner membrane transporter yjeM HVY52_RS01880 ENOG4106V5W HVY52_RS01885 ENOG4106CG8 Inner membrane protein YjeO HVY52_RS01890 ENOG4105EGS Mechanosensitive ion channel HVY52_RS01910 ENOG4106TNF Periplasmic binding protein HVY52_RS01935 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVY52_RS01940 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVY52_RS01945 ENOG4105K8N protein family UPF0079, ATPase HVY52_RS01950 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY52_RS01970 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVY52_RS01975 ENOG4107QJR hflk protein HVY52_RS01980 ENOG4105EPW hflc protein HVY52_RS02000 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVY52_RS02005 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVY52_RS02010 ENOG4105FUX Conserved Protein HVY52_RS02015 ENOG4108P9J Phage shock protein A HVY52_RS02020 ENOG4107VNS Protein of unknown function (DUF2491) HVY52_RS02025 ENOG4105Z6B inner membrane protein yjfl HVY52_RS02030 ENOG4108KXT Conserved Protein HVY52_RS02035 ENOG4106032 Glutathionylspermidine synthase HVY52_RS02040 ENOG4105CSU acyl-Coa dehydrogenase HVY52_RS02045 ENOG4105S17 UPF0379 protein yjfN HVY52_RS02050 ENOG4105WSB biofilm stress and motility protein A HVY52_RS02055 ENOG4108MXZ Esterase HVY52_RS02060 ENOG4105DW5 Transcriptional regulator HVY52_RS02070 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY52_RS02075 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVY52_RS02100 ENOG4105KIT UPF0379 protein yjfY HVY52_RS02115 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVY52_RS02125 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY52_RS02130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY52_RS02135 ENOG41069H7 transport system small permease component HVY52_RS02140 ENOG4107S3R L-aspartate oxidase HVY52_RS02145 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVY52_RS02150 ENOG4105E39 Enoyl-CoA hydratase HVY52_RS02160 ENOG4105CHR reductase HVY52_RS02170 ENOG4105FHY Opacity-associated protein A HVY52_RS02175 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY52_RS02190 ENOG4105DXC membrane HVY52_RS02195 ENOG4105ECR NmrA family HVY52_RS02200 ENOG4105KVH Transcriptional regulator HVY52_RS02205 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVY52_RS02210 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVY52_RS02215 ENOG4108UUE Transcriptional regulator HVY52_RS02220 ENOG41061GZ Protein of unknown function (DUF1107) HVY52_RS02225 ENOG4105C37 (CBS) domain HVY52_RS02230 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVY52_RS02240 ENOG4108YZG isomerase HVY52_RS02245 ENOG4105NYY transcriptional regulator, RpiR HVY52_RS02250 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY52_RS02255 ENOG4105C2J ABC transporter HVY52_RS02260 ENOG4105CNN ABC, transporter HVY52_RS02265 ENOG4105UP7 3-epimerase HVY52_RS02270 ENOG4107TFG D-allose kinase HVY52_RS02275 ENOG4105EUZ Beta-lactamase domain protein HVY52_RS02285 ENOG4105J12 Multidrug resistance protein mdtN HVY52_RS02290 ENOG4108MI0 Resistance protein HVY52_RS02295 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVY52_RS02305 ENOG41082ND Uncharacterized protein yjcO HVY52_RS02310 ENOG4105CK2 sodium dicarboxylate symporter HVY52_RS02315 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY52_RS02320 ENOG41062QD Membrane HVY52_RS02335 ENOG4105CFU surface antigen HVY52_RS02340 ENOG4105MA0 exported protein HVY52_RS02345 ENOG4108ZHD aig2 family HVY52_RS02350 ENOG4105F0N pyrophosphate phospho-hydrolase HVY52_RS02355 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVY52_RS02360 ENOG4105C2J ABC transporter HVY52_RS02365 ENOG4107R9N ABC transporter HVY52_RS02370 ENOG41062B0 ABC transporter, permease HVY52_RS02380 ENOG4105DFU Cell wall formation (By similarity) HVY52_RS02385 ENOG4105N42 UPF0307 protein HVY52_RS02390 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVY52_RS02395 ENOG4108XVM Cytochrome b(562) HVY52_RS02405 ENOG4105K4U addiction module toxin, RelE StbE family HVY52_RS02410 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVY52_RS02415 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVY52_RS02420 ENOG4105CG3 alpha amylase, catalytic region HVY52_RS02425 ENOG4105C5Y PTS System HVY52_RS02430 ENOG4105D4X repressor HVY52_RS02440 ENOG4105KME endoribonuclease L-psp HVY52_RS02455 ENOG4107C93 pyrBI operon leader peptide HVY52_RS02465 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVY52_RS02470 ENOG4105DBV ornithine carbamoyltransferase HVY52_RS02485 ENOG4105XEP YhcH YjgK YiaL family protein HVY52_RS02490 ENOG4105DBV ornithine carbamoyltransferase HVY52_RS02495 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVY52_RS02500 ENOG4108MJ3 acetyltransferase HVY52_RS02505 ENOG4108M3P Membrane HVY52_RS02510 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVY52_RS02515 ENOG4105MYG DNA polymerase iii, chi subunit HVY52_RS02530 ENOG4108M8S permease YjgP YjgQ family protein HVY52_RS02535 ENOG4108K5H permease YjgP YjgQ family protein HVY52_RS02540 ENOG4105W4M Transport-associated protein HVY52_RS02560 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVY52_RS02565 ENOG4106HBN Galactosamine-6-phosphate isomerase HVY52_RS02570 ENOG4105F3R pts system mannose fructose sorbose family iid HVY52_RS02575 ENOG4105ETZ PTS System HVY52_RS02580 ENOG4108UZY PTS System HVY52_RS02590 ENOG4105E70 isomerase HVY52_RS02595 ENOG4105CE4 GlcNAc 6-P deacetylase HVY52_RS02600 ENOG4108YTN IIa component HVY52_RS02605 ENOG4105F3R pts system mannose fructose sorbose family iid HVY52_RS02615 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVY52_RS02625 ENOG4105E98 transcriptional regulator DeoR family HVY52_RS02630 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HVY52_RS02635 ENOG4105ZEG Suppressor protein HVY52_RS02640 ENOG4105CTX dehydratase HVY52_RS02650 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY52_RS02660 ENOG4108CNN domain protein HVY52_RS02665 ENOG4105CWB LysR family transcriptional Regulator HVY52_RS02670 ENOG4105KAF membrAne HVY52_RS02675 ENOG4105CHF Glutathione S-transferase HVY52_RS02680 ENOG4108VBZ doxx family HVY52_RS02685 ENOG4105YJD HVY52_RS02690 ENOG41090KG Inner membrane protein YqjE HVY52_RS02695 ENOG4105NE1 Conserved Protein HVY52_RS02700 ENOG4105WAY exported protein HVY52_RS02710 ENOG4106W5V Membrane HVY52_RS02715 ENOG4107YCY Transcriptional regulator HVY52_RS02720 ENOG4105DPW Major facilitator superfamily MFS_1 HVY52_RS02730 ENOG4105CTX dehydratase HVY52_RS02735 ENOG4105P66 Membrane HVY52_RS02740 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVY52_RS02745 ENOG4105DU1 integral membrane protein, terc HVY52_RS02750 ENOG4105EE0 oxidoreductase HVY52_RS02755 ENOG4108UB4 uncharacterized protein ygjQ HVY52_RS02760 ENOG4108VKG metal-dependent hydrolase HVY52_RS02780 ENOG4105RI1 glycoprotein receptor HVY52_RS02785 ENOG4106CVF DNA replication protein HVY52_RS02790 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HVY52_RS02795 ENOG4107XM3 UPF0442 protein HVY52_RS02800 ENOG4105DWK Membrane HVY52_RS02805 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HVY52_RS02810 ENOG4105EZV Transcriptional regulator HVY52_RS02815 ENOG4108N8T regulatoR HVY52_RS02820 ENOG4108T94 DNA-binding transcriptional activator BglJ HVY52_RS02825 ENOG4108819 ferric iron reductase HVY52_RS02830 ENOG4105YBH Protein of unknown function (DUF1435) HVY52_RS02860 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVY52_RS02865 ENOG4108WPU DNA polymerase III subunit psi HVY52_RS02870 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVY52_RS02875 ENOG4105PAD Hydrolase HVY52_RS02895 ENOG4108R7K Metal Dependent Phosphohydrolase HVY52_RS02900 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HVY52_RS02905 ENOG4105H40 HVY52_RS02935 ENOG4108S1U HVY52_RS02955 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVY52_RS02965 ENOG4108MXB Protein of unknown function (DUF968) HVY52_RS02970 ENOG4105HGD Antitermination protein HVY52_RS02985 ENOG4105VEQ Cold shock protein HVY52_RS02990 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY52_RS03010 ENOG4108YV9 Protein of unknown function (DUF2514) HVY52_RS03015 ENOG4105VEQ Cold shock protein HVY52_RS03025 ENOG4106IAW HVY52_RS03030 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVY52_RS03060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HVY52_RS03135 ENOG4108X9F tail fiber protein HVY52_RS03140 ENOG4105UZW Tail fiber assembly protein HVY52_RS03145 ENOG4105MN3 Resolvase HVY52_RS03150 ENOG4105W3V DNA-binding, transcriptional regulator HVY52_RS03160 ENOG4106FE3 DNA repair HVY52_RS03170 ENOG4105K3G Periplasmic Protein HVY52_RS03180 ENOG4108NRW Phospholipase, patatin family HVY52_RS03185 ENOG4105EYA deoxyribonuclease HVY52_RS03190 ENOG41076CZ activating enzyme HVY52_RS03195 ENOG4105G0K glycine radical enzyme YjjI family HVY52_RS03230 ENOG41062Z9 Membrane HVY52_RS03235 ENOG4105EAC phosphoserine phosphatase HVY52_RS03240 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVY52_RS03245 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVY52_RS03250 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HVY52_RS03260 ENOG4105C5H ABC transporter HVY52_RS03265 ENOG4107SC1 transglycosylase HVY52_RS03275 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVY52_RS03285 ENOG4105UEI Transcriptional Regulator AraC Family HVY52_RS03290 ENOG4108RH0 Crea protein HVY52_RS03295 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY52_RS03300 ENOG4105EB3 Histidine kinase HVY52_RS03305 ENOG4105CT7 inner membrane cred family protein HVY52_RS03310 ENOG41065U4 response regulator HVY52_RS03315 ENOG410759A HVY52_RS03320 ENOG4106FVC RNA methyltransferase HVY52_RS03330 ENOG4105CFH Aspartokinase HVY52_RS03340 ENOG4105D98 threonine synthase HVY52_RS03345 ENOG41062C6 Protein of unknown function (DUF2502) HVY52_RS03355 ENOG4105BZG amino acid carrier protein HVY52_RS03365 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY52_RS03370 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVY52_RS03385 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVY52_RS03395 ENOG41063Z6 transcriptional regulator, lysR family HVY52_RS03405 ENOG410647N response to DNA damage stimulus HVY52_RS03410 ENOG4105DTN riboflavin biosynthesis protein ribF HVY52_RS03415 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HVY52_RS03425 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVY52_RS03445 ENOG4106YYS transcriptional regulatory protein HVY52_RS03450 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY52_RS03455 ENOG4105D9Q decarboxylase (Beta subunit) HVY52_RS03460 ENOG4107QSA Oxaloacetate decarboxylase HVY52_RS03470 ENOG4105D2K citrate carrier protein HVY52_RS03475 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVY52_RS03485 ENOG4105CI0 Citrate lyase HVY52_RS03490 ENOG4105CHY citrate lyase, alpha HVY52_RS03515 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVY52_RS03520 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVY52_RS03525 ENOG4108XNW Transcriptional activatory protein CaiF HVY52_RS03535 ENOG4106YT9 Enoyl-CoA hydratase HVY52_RS03570 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVY52_RS03575 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVY52_RS03580 ENOG4105C54 Major Facilitator superfamily HVY52_RS03595 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVY52_RS03635 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVY52_RS03645 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVY52_RS03650 ENOG4105D3G Pseudouridine synthase HVY52_RS03655 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVY52_RS03660 ENOG4105CQ2 DNA polymerase HVY52_RS03665 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY52_RS03685 ENOG4108RVA ribokinase HVY52_RS03710 ENOG4108KF1 Membrane HVY52_RS03720 ENOG4106SMU thiamine transporter membrane protein HVY52_RS03725 ENOG4105DP9 ABC transporter HVY52_RS03730 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HVY52_RS03740 ENOG4105S8Q sugar efflux transporter HVY52_RS03745 ENOG4105DJB Major Facilitator Superfamily HVY52_RS03750 ENOG4105DND Transcriptional regulator HVY52_RS03755 ENOG4105FF2 Type I DHQase HVY52_RS03760 ENOG4105EMV Major Facilitator HVY52_RS03775 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HVY52_RS03800 ENOG41064T2 transcriptional regulator, lysR family HVY52_RS03805 ENOG4105C7K acetolactate synthase HVY52_RS03810 ENOG4108ZP8 Acetolactate synthase small subunit HVY52_RS03820 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVY52_RS03835 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVY52_RS03840 ENOG4105CJN penicillin-binding protein HVY52_RS03845 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVY52_RS03850 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVY52_RS03860 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVY52_RS03865 ENOG4105CNI cell division protein FtsW HVY52_RS03880 ENOG4105CPF Cell wall formation (By similarity) HVY52_RS03885 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVY52_RS03890 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVY52_RS03895 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVY52_RS03915 ENOG4105M6F mutator MutT protein HVY52_RS03930 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVY52_RS03940 ENOG4105D7Q type ii secretion system HVY52_RS03945 ENOG4107QHF type ii secretion system protein e HVY52_RS03950 ENOG4108ZUW Major pilin subunit HVY52_RS03955 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVY52_RS03960 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY52_RS03965 ENOG4106A72 regulatory protein AmpE HVY52_RS03970 ENOG4105C85 amino acid HVY52_RS03975 ENOG41073TP transcriptional regulator HVY52_RS03980 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVY52_RS03985 ENOG4107QSN dihydrolipoamide acetyltransferase HVY52_RS03990 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY52_RS03995 ENOG4108NST exported protein HVY52_RS04000 ENOG4107QIJ Aconitate hydratase 2 HVY52_RS04020 ENOG4108ZRK uncharacterized protein yacC HVY52_RS04025 ENOG4105E3B Multicopper oxidase HVY52_RS04030 ENOG4105DZG Dehydrogenase HVY52_RS04035 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVY52_RS04040 ENOG41077A9 carbonic anhydrase HVY52_RS04045 ENOG4105DA5 (ABC) transporter HVY52_RS04050 ENOG4105E3A (ABC) transporter HVY52_RS04055 ENOG4108YTN IIa component HVY52_RS04060 ENOG4107BJW polysaccharide deacetylase HVY52_RS04070 ENOG4108A32 Transposase HVY52_RS04085 ENOG4105P0Q fimbrial-like protein YadC HVY52_RS04090 ENOG4105SN2 fimbrial-like adhesin protein HVY52_RS04095 ENOG4105SYG Fimbrial protein HVY52_RS04100 ENOG4108XEY fimbrial-like adhesin protein HVY52_RS04105 ENOG4105CW0 outer membrane usher protein HVY52_RS04110 ENOG4108VEV chaperone HVY52_RS04120 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVY52_RS04125 ENOG4105DJ0 Poly(A) Polymerase HVY52_RS04145 ENOG4107XID 2'-5' rna ligase HVY52_RS04150 ENOG4105CQ7 ATP-dependent helicase HVY52_RS04155 ENOG4105BZ4 penicillin-binding protein HVY52_RS04160 ENOG4105E0K tonB-dependent siderophore receptor HVY52_RS04165 ENOG4105E0A ABC, transporter HVY52_RS04170 ENOG4105J76 Periplasmic binding protein HVY52_RS04175 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVY52_RS04200 ENOG4105EN6 Membrane HVY52_RS04205 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVY52_RS04220 ENOG4105C0H protease HVY52_RS04225 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVY52_RS04235 ENOG4105DIN metallophosphoesterase HVY52_RS04250 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVY52_RS04275 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVY52_RS04280 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVY52_RS04285 ENOG4105KNE Phosphatidate cytidylyltransferase HVY52_RS04290 ENOG4105DZP Membrane-associated zinc metalloprotease HVY52_RS04300 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVY52_RS04305 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVY52_RS04330 ENOG4105C0B DNA polymerase III (alpha subunit) HVY52_RS04335 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HVY52_RS04340 ENOG4105CXN decarboxylase HVY52_RS04345 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVY52_RS04350 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVY52_RS04355 ENOG4105M1T rho-binding antiterminator HVY52_RS04365 ENOG4108VWS Yaeq family HVY52_RS04370 ENOG4108YZN class I peptide chain release factor HVY52_RS04375 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVY52_RS04380 ENOG4108UY0 (LipO)protein HVY52_RS04390 ENOG4108R96 Methyltransferase, YaeB family HVY52_RS04395 ENOG4108R8X outer membrane lipoprotein HVY52_RS04400 ENOG4105D01 (LipO)protein HVY52_RS04405 ENOG4108UMI ABC transporter, permease HVY52_RS04410 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVY52_RS04415 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVY52_RS04450 ENOG4105CV8 reductase HVY52_RS04455 ENOG4105HEI LysR family (Transcriptional regulator HVY52_RS04465 ENOG4105F2W methyltransferase HVY52_RS04470 ENOG4105E9H Lytic Murein transglycosylase HVY52_RS04480 ENOG4105D1A Methyltransferase HVY52_RS04490 ENOG4107RZZ dna polymerase iii epsilon subunit HVY52_RS04500 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY52_RS04505 ENOG4108WN0 inhibitor of vertebrate lysozyme HVY52_RS04510 ENOG4107QPN acyl-Coa dehydrogenase HVY52_RS04520 ENOG4105E7A Glutamine amidotransferase HVY52_RS04525 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVY52_RS04530 ENOG4108YS0 lipoprotein YafL HVY52_RS04540 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY52_RS04560 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVY52_RS04565 ENOG4105CUZ uba thif-type nad fad binding protein HVY52_RS04570 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVY52_RS04575 ENOG4105C9B Cysteine desulfurase HVY52_RS04580 ENOG4105M5B (LipO)protein HVY52_RS04585 ENOG4105ETT transcriptional Regulator, LysR family HVY52_RS04590 ENOG4105M08 Membrane HVY52_RS04605 ENOG4105EJQ L-serine dehydratase HVY52_RS04610 ENOG4105C44 Serine transporter HVY52_RS04615 ENOG4105EWT decarboxylase family HVY52_RS04630 ENOG4105WP7 tRNA pseudouridine synthase C HVY52_RS04635 ENOG4105DR9 pseudouridine synthase HVY52_RS04640 ENOG4105QDK Flavodoxin HVY52_RS04645 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVY52_RS04660 ENOG4105EQX glucarate dehydratase HVY52_RS04665 ENOG4105EQX glucarate dehydratase HVY52_RS04670 ENOG4105BZW Glycerate kinase HVY52_RS04675 ENOG4105BZU Histidine kinase HVY52_RS04680 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVY52_RS04685 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY52_RS04690 ENOG4105DXN mazG family HVY52_RS04705 ENOG4105HA9 of methanol dehydrogenase type HVY52_RS04715 ENOG4105HA9 of methanol dehydrogenase type HVY52_RS04725 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVY52_RS04735 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVY52_RS04755 ENOG4107635 Hok Gef family protein HVY52_RS04760 ENOG4105DTT CRISPR-associated helicase, cas3 HVY52_RS04775 ENOG41060M0 Crispr-associated protein, cse4 family HVY52_RS04780 ENOG4108VWQ crispr-associated protein HVY52_RS04790 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVY52_RS04795 ENOG4105PWE CRISPR-associated protein cas2 HVY52_RS04800 ENOG4108MXK alkaline phosphatase isozyme conversion HVY52_RS04820 ENOG4105N0Z inner membrane protein ygbE HVY52_RS04855 ENOG4108K5P (LipO)protein HVY52_RS04860 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY52_RS04870 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY52_RS04875 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY52_RS04880 ENOG4105KZM cytoplasmic protein HVY52_RS04885 ENOG4105MEW serine threonine protein phosphatase HVY52_RS04905 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVY52_RS04920 ENOG4105C2J ABC transporter HVY52_RS04925 ENOG4105CNN ABC, transporter HVY52_RS04930 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY52_RS04935 ENOG4107EDW L-fucose operon activator HVY52_RS04940 ENOG4105VXR cytoplasmic protein HVY52_RS04945 ENOG4105F4R Transcriptional regulator mode HVY52_RS04950 ENOG4108JUA Transcriptional regulator HVY52_RS04955 ENOG4105C45 hydrogenase expression formation protein (HypE) HVY52_RS04960 ENOG4105CQS hydrogenase expression formation protein HypD HVY52_RS04965 ENOG41083WG hydrogenase assembly chaperone HVY52_RS04970 ENOG4107RSS Hydrogenase accessory protein HypB HVY52_RS04975 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVY52_RS04980 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVY52_RS04985 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY52_RS04990 ENOG4107R30 NADH dehydrogenase HVY52_RS04995 ENOG4107TDF Formate hydrogenlyase subunit 4 HVY52_RS05000 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY52_RS05005 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVY52_RS05010 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY52_RS05015 ENOG4105I6X formate hydrogenlyase maturation HVY52_RS05020 ENOG4108MG9 hydrogenase 3 maturation protease HVY52_RS05025 ENOG4105CS2 ec 3.2.1.21 HVY52_RS05030 ENOG4105C5Y PTS System HVY52_RS05035 ENOG4105DDV Transcriptional regulator (LacI family HVY52_RS05040 ENOG4108RC0 Electron transport protein HVY52_RS05045 ENOG4105C8H hydrogenase maturation protein Hypf HVY52_RS05065 ENOG4105C2X Arabinose 5-phosphate isomerase HVY52_RS05075 ENOG4105CVE Lytic murein transglycosylase HVY52_RS05085 ENOG4107TH8 cina domain protein HVY52_RS05105 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVY52_RS05135 ENOG4107VXZ Hydrolase HVY52_RS05140 ENOG4105W39 Membrane HVY52_RS05165 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY52_RS05170 ENOG4105CW7 secretion protein, HlyD family HVY52_RS05175 ENOG4105NTK Transcriptional repressor Mpra HVY52_RS05180 ENOG4105ZED uncharacterized protein ygaH HVY52_RS05185 ENOG4108UMN azlc family HVY52_RS05195 ENOG4105GIJ Glycine betaine HVY52_RS05200 ENOG4108HQS Glycine betaine HVY52_RS05205 ENOG4108IJ7 Glycine betaine HVY52_RS05210 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY52_RS05215 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY52_RS05225 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVY52_RS05230 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY52_RS05240 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVY52_RS05245 ENOG4108WMJ Protein of unknown function (DUF2002) HVY52_RS05255 ENOG4108X73 DNA- binding protein HVY52_RS05260 ENOG4108V62 Rhodanese domain protein HVY52_RS05265 ENOG41080HT Transcriptional regulator, arsr family HVY52_RS05270 ENOG4105VPI YqaE family transport protein HVY52_RS05275 ENOG4109066 lysm domain bon superfamily protein HVY52_RS05280 ENOG4108PVQ transcriptional regulator HVY52_RS05285 ENOG4105C85 amino acid HVY52_RS05290 ENOG4108JPW Aminotransferase HVY52_RS05295 ENOG4105C26 Dehydrogenase HVY52_RS05300 ENOG4105D5U fad dependent oxidoreductase HVY52_RS05310 ENOG4108NUU Transcriptional regulator HVY52_RS05315 ENOG4105SZ2 membrAne HVY52_RS05320 ENOG4107SNB ankyrin repeat protein YahD HVY52_RS05325 ENOG4105N16 Protein of unknown function (DUF2877) HVY52_RS05330 ENOG4107R1Q Membrane protein FdrA HVY52_RS05335 ENOG4107REC cytoplasmic protein HVY52_RS05340 ENOG4105C5B carbamate kinase HVY52_RS05345 ENOG4105DZC cytosine deaminase HVY52_RS05350 ENOG4105DTA methyltransferase HVY52_RS05360 ENOG4105DQ4 alcohol dehydrogenase HVY52_RS05365 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY52_RS05370 ENOG4108YZG isomerase HVY52_RS05380 ENOG4105CMT Dihydroxyacetone kinase HVY52_RS05385 ENOG4105CP7 Triose-phosphate isomerase HVY52_RS05390 ENOG4108KFM Xylose Isomerase Domain-Containing protein HVY52_RS05395 ENOG4106J7G oxidoreductase HVY52_RS05400 ENOG4105DKT Transcriptional regulator HVY52_RS05405 ENOG41083A2 UPF0145 protein HVY52_RS05410 ENOG4105Y50 Virulence Protein HVY52_RS05470 ENOG4105DFP Integrase HVY52_RS05485 ENOG4108Z1B Cyclase dehydrase HVY52_RS05495 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY52_RS05500 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVY52_RS05515 ENOG4108JU6 CBS domain protein HVY52_RS05520 ENOG4106KVJ cytochrome C assembly protein HVY52_RS05525 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVY52_RS05550 ENOG4105QP9 Protein of unknown function (DUF2799) HVY52_RS05555 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY52_RS05560 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVY52_RS05565 ENOG4105CQC Prephenate dehydratase HVY52_RS05575 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVY52_RS05580 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVY52_RS05585 ENOG4105C34 Pseudouridine synthase HVY52_RS05590 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVY52_RS05595 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY52_RS05620 ENOG4105CSH Transporter HVY52_RS05625 ENOG4105T42 (LipO)protein HVY52_RS05630 ENOG4105JIM Phosphatidylserine synthase HVY52_RS05635 ENOG4105CD5 CoA-binding domain protein HVY52_RS05640 ENOG4106IUH DTW domain containing protein HVY52_RS05645 ENOG4105K63 Thioredoxin HVY52_RS05650 ENOG4105EIB trna rrna methyltransferase HVY52_RS05675 ENOG4105C1J atp-dependent rna helicase HVY52_RS05685 ENOG4108IYU L-aspartate oxidase HVY52_RS05695 ENOG4105EMN RNA polymerase sigma factor HVY52_RS05700 ENOG41069PW sigma-e factor negative regulatory protein HVY52_RS05705 ENOG4105VQK sigma E regulatory protein, MucB RseB HVY52_RS05710 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVY52_RS05720 ENOG4105C3F Signal peptidase i HVY52_RS05740 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVY52_RS05755 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVY52_RS05760 ENOG4106G6Q Transcriptional regulator HVY52_RS05765 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVY52_RS05770 ENOG4108Z6B deaminase HVY52_RS05780 ENOG4108ETH Formylglycinamide ribotide synthetase HVY52_RS05785 ENOG4107WP9 Histidine kinase HVY52_RS05790 ENOG4108SKK alpha helix protein HVY52_RS05795 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY52_RS05820 ENOG4107RE1 Inosine-guanosine kinase HVY52_RS05825 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVY52_RS05830 ENOG4105EU0 Major facilitator Superfamily HVY52_RS05835 ENOG4105CGH 5'-nucleotidase HVY52_RS05850 ENOG4108Z66 YbaK ebsC protein HVY52_RS05855 ENOG4105MBR gumn family HVY52_RS05860 ENOG41080ET plasmid maintenance system killer protein HVY52_RS05865 ENOG41081XE plasmid maintenance system antidote protein, xre family HVY52_RS05870 ENOG4105C59 p-type ATPase HVY52_RS05875 ENOG4107RY6 amino acid HVY52_RS05895 ENOG4107QZV Type I secretion membrane fusion protein HVY52_RS05900 ENOG4108Z6Z Transcriptional regulator HVY52_RS05905 ENOG4105G5H Membrane HVY52_RS05910 ENOG4107QX8 SPFH domain, Band 7 family protein HVY52_RS05915 ENOG41083J0 (ABC) transporter HVY52_RS05920 ENOG4105C4B ABC transporter, permease HVY52_RS05925 ENOG4107QR8 Thioredoxin HVY52_RS05930 ENOG4105E1F short-chain dehydrogenase reductase HVY52_RS05935 ENOG4108UJV acyl-CoA thioesterase i HVY52_RS05940 ENOG4108I0Y (ABC) transporter HVY52_RS05945 ENOG4105CV6 ABC transporter, permease HVY52_RS05950 ENOG4105GMB type VI secretion system effector, hcp1 family HVY52_RS05965 ENOG4107653 Transcriptional regulator HVY52_RS05975 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVY52_RS05980 ENOG41060W2 glyoxylate carboligase HVY52_RS05985 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVY52_RS05990 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY52_RS05995 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVY52_RS06005 ENOG4105DTE Xanthine uracil vitamin C permease HVY52_RS06010 ENOG4105BZW Glycerate kinase HVY52_RS06015 ENOG4105S0E allantoin catabolism protein HVY52_RS06020 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVY52_RS06025 ENOG4105DG4 malate L-lactate dehydrogenase HVY52_RS06030 ENOG4107R1Q Membrane protein FdrA HVY52_RS06035 ENOG4107REC cytoplasmic protein HVY52_RS06040 ENOG4105G5A Protein of unknown function (DUF2877) HVY52_RS06045 ENOG4105C5B carbamate kinase HVY52_RS06050 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVY52_RS06055 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVY52_RS06070 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY52_RS06080 ENOG4105S2T inner membrane protein YbcI HVY52_RS06085 ENOG4105WQ3 Rna-binding protein HVY52_RS06115 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY52_RS06125 ENOG4108SB3 DoxX Family HVY52_RS06130 ENOG4105D8G Major Facilitator superfamily HVY52_RS06135 ENOG4108MN2 Stationary phase inducible protein CsiE HVY52_RS06140 ENOG4107XM9 (LipO)protein HVY52_RS06145 ENOG4105ECY inositol monophosphatase HVY52_RS06165 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVY52_RS06185 ENOG4108ZIT Ferredoxin, 2FE-2S HVY52_RS06190 ENOG4105WVQ Fe-S assembly protein IscX HVY52_RS06200 ENOG4105YYA enhanced serine sensitivity protein SseB HVY52_RS06205 ENOG4105KHC sulfurtransferase HVY52_RS06210 ENOG4105DN3 alpha-2-macroglobulin domain protein HVY52_RS06215 ENOG4108JQB penicillin-binding protein 1C HVY52_RS06245 ENOG4105N21 Membrane HVY52_RS06260 ENOG4105VPD cellular component movement HVY52_RS06285 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVY52_RS06300 ENOG4108R1E Serine threonine protein phosphatase 1 HVY52_RS06325 ENOG41076J9 exonuclease VIII HVY52_RS06410 ENOG4108TFU terminase (Small subunit) HVY52_RS06525 ENOG4105XB7 anti-repressor protein HVY52_RS06550 ENOG4105NVB glycoside hydrolase, family 19 HVY52_RS06565 ENOG41066DY Membrane HVY52_RS06570 ENOG4108ZMA Outer membrane lipoprotein HVY52_RS06575 ENOG41062G3 Protein of unknown function (DUF2633) HVY52_RS06580 ENOG4105BZU Histidine kinase HVY52_RS06585 ENOG4105C9X ppx gppa phosphatase HVY52_RS06590 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVY52_RS06595 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVY52_RS06610 ENOG4105C2W permease HVY52_RS06615 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVY52_RS06620 ENOG4105K89 arsenate reductase HVY52_RS06625 ENOG4105ERG peptidase m48, ste24p HVY52_RS06630 ENOG4105C02 permease HVY52_RS06635 ENOG4108JUA Transcriptional regulator HVY52_RS06640 ENOG4105I6X formate hydrogenlyase maturation HVY52_RS06645 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY52_RS06655 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY52_RS06660 ENOG4108JPZ Monovalent cation H antiporter subunit D HVY52_RS06665 ENOG4107WQX hydrogenase 4 membrane subunit HVY52_RS06670 ENOG4105D65 subunit l HVY52_RS06675 ENOG4107TDF Formate hydrogenlyase subunit 4 HVY52_RS06680 ENOG4108JPZ Monovalent cation H antiporter subunit D HVY52_RS06685 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY52_RS06690 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVY52_RS06695 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVY52_RS06705 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY52_RS06720 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVY52_RS06725 ENOG4105CGZ zinc metallopeptidase HVY52_RS06735 ENOG4106KED esterase YpfH HVY52_RS06750 ENOG4105KUZ arsenate reductase HVY52_RS06760 ENOG4105BZS acriflavin resistance protein HVY52_RS06765 ENOG4105BZU Histidine kinase HVY52_RS06770 ENOG4105BZ8 glutamate synthase HVY52_RS06780 ENOG4108PVD exported protein HVY52_RS06785 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY52_RS06790 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY52_RS06795 ENOG4105C6K Malic enzyme HVY52_RS06800 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVY52_RS06805 ENOG4106S4J ethanolamine utilization protein EutP HVY52_RS06810 ENOG4105NDK ethanolamine utilization protein HVY52_RS06815 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVY52_RS06820 ENOG4107WUY phosphate acetyltransferase HVY52_RS06825 ENOG4105KNY Microcompartments protein HVY52_RS06830 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVY52_RS06835 ENOG4108EKI Dehydrogenase HVY52_RS06840 ENOG4107RWI ethanolamine utilization protein eutJ HVY52_RS06845 ENOG4105C0A alcohol dehydrogenase HVY52_RS06850 ENOG4105ENY Ethanolamine utilization protein eutH HVY52_RS06855 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVY52_RS06860 ENOG4105CPD ethanolamine ammonia-lyase HVY52_RS06870 ENOG4106D67 ethanolamine utilization protein HVY52_RS06875 ENOG4108X49 Ethanolamine utilization protein EutK HVY52_RS06880 ENOG4108K3Z AraC family transcriptional regulator HVY52_RS06900 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVY52_RS06910 ENOG4105QZU Inner membrane protein YfeZ HVY52_RS06915 ENOG4105E7K (LipO)protein HVY52_RS06920 ENOG4105EZR dyp-type peroxidase family protein HVY52_RS06925 ENOG4107S1E Beta-lactamase HVY52_RS06930 ENOG4105C5Y PTS System HVY52_RS06945 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVY52_RS06950 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVY52_RS06955 ENOG4108I5D sulfate abc transporter HVY52_RS06960 ENOG4105ECW sulfate abc transporter HVY52_RS06965 ENOG4108IJ6 ABC transporter HVY52_RS06970 ENOG4105C6T cysteine synthase HVY52_RS06975 ENOG4105M0Y HVY52_RS06985 ENOG4105C5Y PTS System HVY52_RS06990 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY52_RS07000 ENOG4105C6T cysteine synthase HVY52_RS07010 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HVY52_RS07020 ENOG4105VRT cytoplasmic protein HVY52_RS07025 ENOG4105DHU Bile acid HVY52_RS07030 ENOG4108NFH Sugar hydrolase HVY52_RS07035 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVY52_RS07040 ENOG4105EAA nucleoside HVY52_RS07050 ENOG4105CN8 Transcriptional regulator HVY52_RS07075 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HVY52_RS07080 ENOG4105GXM Putative transcription regulator (DUF1323) HVY52_RS07085 ENOG4105HZG regulatoR HVY52_RS07100 ENOG4108KMM Diguanylate cyclase HVY52_RS07105 ENOG4105D9N nucleoside HVY52_RS07115 ENOG4109076 Conserved Protein HVY52_RS07130 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVY52_RS07135 ENOG410863U PTS System HVY52_RS07140 ENOG4105DC7 peptidase M24 HVY52_RS07145 ENOG4105CN9 Peptidase m42 family protein HVY52_RS07150 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY52_RS07155 ENOG4108CIP transcriptional regulator HVY52_RS07160 ENOG4105DY9 regulatoR HVY52_RS07165 ENOG4108HRK Histidine kinase HVY52_RS07170 ENOG4105CHM Aminotransferase HVY52_RS07180 ENOG4105D1S lipid A biosynthesis HVY52_RS07185 ENOG4105W9M Membrane HVY52_RS07200 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HVY52_RS07220 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HVY52_RS07230 ENOG4105CHR reductase HVY52_RS07240 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HVY52_RS07255 ENOG4105S64 Formate nitrite transporter HVY52_RS07260 ENOG410903C (LipO)protein HVY52_RS07265 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVY52_RS07270 ENOG4105KZW UPF0381 protein HVY52_RS07285 ENOG4108BY2 phosphohistidine phosphatase HVY52_RS07295 ENOG4106PG1 outer membrane usher protein HVY52_RS07300 ENOG4108FZ9 Chaperone HVY52_RS07305 ENOG4105NEV Fimbrial HVY52_RS07310 ENOG4105UGQ Fimbrial HVY52_RS07315 ENOG4105US4 fimbrial-like protein yfcP HVY52_RS07335 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HVY52_RS07345 ENOG4105EJ9 Membrane HVY52_RS07350 ENOG4108BPE -transporting atpase HVY52_RS07355 ENOG4105MH2 YfcL protein HVY52_RS07360 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVY52_RS07365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY52_RS07370 ENOG4105F9N Major Facilitator Superfamily HVY52_RS07375 ENOG4106WZ1 flagella biosynthesis regulator HVY52_RS07385 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY52_RS07395 ENOG4105DQR SNARE associated Golgi HVY52_RS07405 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVY52_RS07410 ENOG4108S3P Sporulation domain protein HVY52_RS07415 ENOG4105E96 Colicin v production protein HVY52_RS07420 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVY52_RS07425 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY52_RS07430 ENOG4105E89 ABC transporter HVY52_RS07435 ENOG4105E89 ABC transporter HVY52_RS07440 ENOG4105DSP amino acid AbC transporter HVY52_RS07445 ENOG4106YG3 ABC transporter HVY52_RS07450 ENOG4108JEH abc transporter atp-binding protein HVY52_RS07455 ENOG4105DNE Transposase HVY52_RS07460 ENOG4105ECP epimerase HVY52_RS07465 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVY52_RS07470 ENOG4105CYM Glutathione S-transferase HVY52_RS07475 ENOG4108SHQ Glutathione S-transferase HVY52_RS07480 ENOG4108RE9 Phosphodiesterase HVY52_RS07485 ENOG4105PTV Nudix Hydrolase HVY52_RS07490 ENOG4105K2J Transcriptional regulator HVY52_RS07505 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY52_RS07510 ENOG4108HHA Transketolase HVY52_RS07515 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVY52_RS07520 ENOG4105C6K Malic enzyme HVY52_RS07525 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVY52_RS07535 ENOG4105XWI UPF0304 protein HVY52_RS07540 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVY52_RS07545 ENOG4107QWE )-transporter HVY52_RS07550 ENOG4105DK2 UPF0207 protein HVY52_RS07555 ENOG4105CHM Aminotransferase HVY52_RS07560 ENOG4107NQ8 LysR family Transcriptional regulator HVY52_RS07575 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY52_RS07580 ENOG4105GKE subunit e HVY52_RS07585 ENOG4107QIZ NADH dehydrogenase HVY52_RS07590 ENOG4108IEH NADH dehydrogenase subunit g HVY52_RS07605 ENOG4107UFS subunit j HVY52_RS07615 ENOG4105D65 subunit l HVY52_RS07620 ENOG4105C8S subunit m HVY52_RS07630 ENOG4105ZD8 HVY52_RS07640 ENOG4105GDX Domain of unknown function (DUF1877) HVY52_RS07645 ENOG4105CP2 von willebrand factor, type a HVY52_RS07660 ENOG4107YB6 acetyltransferase, (GNAT) family HVY52_RS07665 ENOG4105TNS Conserved Protein HVY52_RS07670 ENOG4105E4F Isochorismate synthase HVY52_RS07685 ENOG4108IPT Naphthoate synthase HVY52_RS07695 ENOG4105CEY Amp-dependent synthetase and ligase HVY52_RS07700 ENOG4106GZG polymyxin resistance protein B HVY52_RS07750 ENOG4108UII YfaZ family HVY52_RS07755 ENOG4108EWA cinA-like protein HVY52_RS07770 ENOG4105DNE Transposase HVY52_RS07775 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY52_RS07785 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVY52_RS07790 ENOG4105CXY transporter HVY52_RS07795 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVY52_RS07800 ENOG4105FQR PH-inducible protein involved in stress response HVY52_RS07805 ENOG4105XPH Ferredoxin HVY52_RS07810 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY52_RS07815 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY52_RS07820 ENOG4107GHC outer membrane autotransporter HVY52_RS07830 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY52_RS07835 ENOG4105CHU acetyl-coa acetyltransferase HVY52_RS07840 ENOG4105CRW Short chain fatty acid transporter HVY52_RS07845 ENOG4107QNJ CoA-transferase subunit B HVY52_RS07850 ENOG4107QP7 CoA-transferase subunit A HVY52_RS07855 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY52_RS07860 ENOG4105BZU Histidine kinase HVY52_RS07865 ENOG4105BZU Histidine kinase HVY52_RS07870 ENOG41068CG regulatoR HVY52_RS07875 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVY52_RS07880 ENOG4105FCK Membrane HVY52_RS07885 ENOG4105CJ2 (LipO)protein HVY52_RS07890 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY52_RS07895 ENOG4105CF1 Alkylated DNA repair protein HVY52_RS07900 ENOG4105IBP Cyclic peptide transporter HVY52_RS07910 ENOG4105CDA abc transporter atp-binding protein HVY52_RS07915 ENOG4105E5Q amino acid AbC transporter HVY52_RS07920 ENOG4107R0W ABC transporter HVY52_RS07930 ENOG4107AQZ Membrane HVY52_RS07935 ENOG4108T1M outer membrane protein x HVY52_RS07940 ENOG4108I6E Sulfatase HVY52_RS07950 ENOG4105KST dependent repressor HVY52_RS07955 ENOG4105F4P )-transporter HVY52_RS07960 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY52_RS07965 ENOG4105C5H ABC transporter HVY52_RS07970 ENOG4108HCJ Hydrolase HVY52_RS07980 ENOG4105F1A Pyruvate formate-lyase HVY52_RS07985 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY52_RS07990 ENOG4105D06 uba thif-type nad fad binding protein HVY52_RS07995 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVY52_RS08000 ENOG4108JQ6 ABC transporter HVY52_RS08005 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY52_RS08010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY52_RS08020 ENOG4105BZU Histidine kinase HVY52_RS08025 ENOG41064RH membrane protein YliF HVY52_RS08035 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVY52_RS08040 ENOG4105D8V Glucose sorbosone dehydrogenase HVY52_RS08045 ENOG4108TGY Glutathione S-transferase HVY52_RS08050 ENOG4105DZ1 carboxypeptidase HVY52_RS08055 ENOG4107FB0 transcriptional regulator DeoR family HVY52_RS08060 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVY52_RS08065 ENOG4107QF7 multi-drug HVY52_RS08075 ENOG4108HCJ Hydrolase HVY52_RS08080 ENOG4106UW1 Major Facilitator superfamily HVY52_RS08085 ENOG4108RFG Tetr family transcriptional regulator HVY52_RS08095 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY52_RS08115 ENOG4105MEH HVY52_RS08140 ENOG4105KSC Transcriptional regulator, TraR DksA family HVY52_RS08145 ENOG4105DFE Dna adenine methylase HVY52_RS08155 ENOG4105VZ1 Replication Protein HVY52_RS08190 ENOG4105ED4 portal protein HVY52_RS08280 ENOG4108US3 tail fiber assembly HVY52_RS08320 ENOG4105ZTC transcriptional activator, Ogr delta HVY52_RS08330 ENOG4105GWF inner membrane protein YbjM HVY52_RS08335 ENOG4108DBC nitroreductase HVY52_RS08345 ENOG4108RMJ sensory transduction regulator HVY52_RS08350 ENOG4107RUE extracellular solute-binding protein family 1 HVY52_RS08355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY52_RS08360 ENOG4105F38 ABC transporter, permease HVY52_RS08365 ENOG4105D38 putrescine abc transporter HVY52_RS08370 ENOG4105RBQ inner membrane protein ybjO HVY52_RS08380 ENOG4106TNF Periplasmic binding protein HVY52_RS08385 ENOG4105DMR ABC, transporter HVY52_RS08390 ENOG4105GBT ABC transporter HVY52_RS08395 ENOG4106PMH Extracellular solute-binding protein family 3 HVY52_RS08400 ENOG4105E5Z arginine transporter ATP-binding subunit HVY52_RS08405 ENOG41064MM (LipO)protein HVY52_RS08415 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY52_RS08420 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY52_RS08425 ENOG4105CGD Nad-dependent epimerase dehydratase HVY52_RS08430 ENOG4105C5W Aldolase HVY52_RS08435 ENOG4105C7K acetolactate synthase HVY52_RS08445 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY52_RS08455 ENOG4105DWU Membrane HVY52_RS08460 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY52_RS08465 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVY52_RS08475 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVY52_RS08485 ENOG4105VEQ Cold shock protein HVY52_RS08495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY52_RS08505 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVY52_RS08515 ENOG4108JJ8 (ABC) transporter HVY52_RS08520 ENOG4108JJ9 ABC, transporter HVY52_RS08525 ENOG4105C3M thioredoxin reductase HVY52_RS08535 ENOG4105CNU cell division protein FtsK HVY52_RS08545 ENOG4105D1H recombination factor protein RarA HVY52_RS08555 ENOG4105CHJ isochorismatase hydrolase HVY52_RS08565 ENOG4105E5D amino acid HVY52_RS08575 ENOG4105F1A Pyruvate formate-lyase HVY52_RS08580 ENOG4105C6N Formate acetyltransferase HVY52_RS08585 ENOG4105TMB Formate nitrite transporter HVY52_RS08590 ENOG4105DDY UPF0142 protein ycaO HVY52_RS08595 ENOG4107VMU Membrane HVY52_RS08615 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVY52_RS08625 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVY52_RS08630 ENOG4105BZ1 (ABC) transporter HVY52_RS08640 ENOG4105T0Z Conserved Protein HVY52_RS08655 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVY52_RS08660 ENOG4107S90 membrAne HVY52_RS08665 ENOG4106371 Methyltransferase HVY52_RS08675 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVY52_RS08685 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVY52_RS08690 ENOG4105EAQ (twin-arginine translocation) pathway signal HVY52_RS08695 ENOG4105C5X domain protein HVY52_RS08700 ENOG4105CGF Aromatic amino acid aminotransferase HVY52_RS08705 ENOG4105FCK Membrane HVY52_RS08720 ENOG4105CD8 aminopeptidase N HVY52_RS08725 ENOG4105E2Y ABC, transporter HVY52_RS08730 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVY52_RS08740 ENOG4105GVF (ABC) transporter HVY52_RS08745 ENOG4108UZX fmn reductase HVY52_RS08755 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVY52_RS08760 ENOG4105QVC MOSC domain-containing protein HVY52_RS08770 ENOG4105C5H ABC transporter HVY52_RS08775 ENOG4105F1S paraquat-inducible protein a HVY52_RS08780 ENOG4105DY2 Paraquat-inducible protein b HVY52_RS08785 ENOG4108Q2G (LipO)protein HVY52_RS08790 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVY52_RS08800 ENOG4105DAN ATP-dependent protease HVY52_RS08820 ENOG4108RZ1 DNA transformation protein HVY52_RS08825 ENOG4105EM2 membrane HVY52_RS08830 ENOG410901E Membrane HVY52_RS08835 ENOG41088T4 Helicase IV HVY52_RS08850 ENOG4105K4P CoA-binding domain protein HVY52_RS08865 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVY52_RS08870 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVY52_RS08875 ENOG4108MN8 Membrane HVY52_RS08890 ENOG4105E3S small subunit HVY52_RS08895 ENOG4105DPX Hydrogenase, large subunit HVY52_RS08900 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVY52_RS08905 ENOG4108USZ hydrogenase HVY52_RS08910 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVY52_RS08915 ENOG4105MVP hydrogenase-1 operon protein HyaF HVY52_RS08920 ENOG4106RHG Yeca family HVY52_RS08925 ENOG4105E0U tyrosine-specific transport protein HVY52_RS08930 ENOG4105VVZ metal-binding protein HVY52_RS08935 ENOG41090A1 ferritin HVY52_RS08940 ENOG4105P23 (LipO)protein HVY52_RS08945 ENOG4108UEC Ferritin-like protein HVY52_RS08955 ENOG4105C2J ABC transporter HVY52_RS08960 ENOG4105CNN ABC, transporter HVY52_RS08965 ENOG4108K4C ec 3.1.3.12 HVY52_RS08975 ENOG4108VA4 Universal stress protein HVY52_RS08985 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVY52_RS08990 ENOG4107RD7 Flagellar Motor Protein, MotA HVY52_RS08995 ENOG4105ER2 Ompa motb domain protein HVY52_RS09000 ENOG4105CBS Chea signal transduction histidine kinase HVY52_RS09005 ENOG4108V3W Chemotaxis protein, CheW HVY52_RS09035 ENOG4105C8Q Methyl-accepting chemotaxis HVY52_RS09040 ENOG4105BZU Histidine kinase HVY52_RS09050 ENOG4108VYJ response regulator receiver protein HVY52_RS09075 ENOG4105MWK D-amino acid dehydrogenase, small subunit HVY52_RS09080 ENOG4105RQF LysR family Transcriptional regulator HVY52_RS09090 ENOG4105D6F Phosphatase HVY52_RS09095 ENOG4105XH3 HVY52_RS09105 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVY52_RS09110 ENOG4108R86 Transcriptional regulator HVY52_RS09115 ENOG4105BZU Histidine kinase HVY52_RS09120 ENOG41064RH membrane protein YliF HVY52_RS09125 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY52_RS09130 ENOG4107EEX Cellulose synthase regulator protein HVY52_RS09140 ENOG41066VF YeeE YedE family protein HVY52_RS09145 ENOG4108W9D (LipO)protein HVY52_RS09150 ENOG4105E5K Alpha-amylase HVY52_RS09155 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HVY52_RS09160 ENOG4105MQ3 flagellar protein FliS HVY52_RS09165 ENOG4105DTS flagellar hook-associated HVY52_RS09175 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY52_RS09180 ENOG4108M9K flagella biosynthesis protein FliZ HVY52_RS09185 ENOG4105EAB amino acid AbC transporter HVY52_RS09195 ENOG4105E5Q amino acid AbC transporter HVY52_RS09200 ENOG4105CDA abc transporter atp-binding protein HVY52_RS09205 ENOG4105VJY transcriptional regulator HVY52_RS09210 ENOG4105XVG cytoplasmic protein HVY52_RS09215 ENOG4105WH1 Two component transcriptional regulator luxr family HVY52_RS09245 ENOG4107SVH Potassium channel protein HVY52_RS09250 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY52_RS09255 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY52_RS09270 ENOG4105BZU Histidine kinase HVY52_RS09275 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVY52_RS09280 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVY52_RS09285 ENOG4105CUW cytochrome C-TYPE protein HVY52_RS09290 ENOG4107QY8 reductase HVY52_RS09300 ENOG4105D00 flagellar biosynthetic protein flhB HVY52_RS09305 ENOG4105D7B Flagellar biosynthesis protein flha HVY52_RS09310 ENOG4105W13 flagellar protein HVY52_RS09320 ENOG4106ZCM YecM protein HVY52_RS09340 ENOG4105WJG Glutathione HVY52_RS09345 ENOG41081XQ Conserved Protein HVY52_RS09350 ENOG4105D3W isochorismatase HVY52_RS09360 ENOG4108TIT dATP pyrophosphohydrolase HVY52_RS09365 ENOG4105CDY transcriptional regulatory protein HVY52_RS09375 ENOG4107S01 Repressor protein MetJ HVY52_RS09395 ENOG4105FAV ABC, transporter HVY52_RS09405 ENOG4105NXV High-affinity zinc uptake system protein HVY52_RS09410 ENOG4105DR5 peptidase HVY52_RS09415 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVY52_RS09420 ENOG4105CA9 Pyruvate kinase HVY52_RS09425 ENOG4106KNT transcriptional regulator HVY52_RS09430 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVY52_RS09435 ENOG4105C01 Dihydroxy-acid dehydratase HVY52_RS09440 ENOG4108UHU Aldolase HVY52_RS09445 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HVY52_RS09450 ENOG4105X2V dna damage-inducible protein HVY52_RS09460 ENOG4108Q2J Inner membrane protein YebE HVY52_RS09465 ENOG4105CUG Oligopeptidase b HVY52_RS09470 ENOG4105UMD exodeoxyribonuclease X HVY52_RS09475 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY52_RS09480 ENOG4105MPK DNA polymerase III subunit theta HVY52_RS09485 ENOG4105FXM Copper resistance protein HVY52_RS09490 ENOG4108PNC copper resistance HVY52_RS09495 ENOG4105NKT exported protein HVY52_RS09500 ENOG4108R1E Serine threonine protein phosphatase 1 HVY52_RS09505 ENOG4105UVW uncharacterized protein yebW HVY52_RS09510 ENOG4105WT8 Protein of unknown function (DUF1480) HVY52_RS09520 ENOG4105DY2 Paraquat-inducible protein b HVY52_RS09525 ENOG4105H2K paraquat-inducible protein a HVY52_RS09530 ENOG4108ZGC gaf domain protein HVY52_RS09540 ENOG4105CN1 protease HVY52_RS09550 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY52_RS09555 ENOG4105J4Q Transcriptional regulator HVY52_RS09560 ENOG4105TIK HVY52_RS09570 ENOG4105Q3Y exported protein HVY52_RS09585 ENOG4105DHI Methyltransferase HVY52_RS09600 ENOG4105F3R pts system mannose fructose sorbose family iid HVY52_RS09605 ENOG4105ETZ PTS System HVY52_RS09610 ENOG4105DAS pts system HVY52_RS09615 ENOG4105EE5 Membrane protein terC HVY52_RS09620 ENOG4107XTP (EAL) domain protein HVY52_RS09625 ENOG4105EJQ L-serine dehydratase HVY52_RS09635 ENOG4105CRQ synthase (Component I) HVY52_RS09650 ENOG4105V2F Uncharacterized protein yoac HVY52_RS09655 ENOG4105M4H endoribonuclease L-psp HVY52_RS09670 ENOG4105DVT helicase HVY52_RS09675 ENOG41072GX Peptidase M22 Glycoprotease HVY52_RS09680 ENOG4105Y4Z Outer Membrane Lipoprotein HVY52_RS09685 ENOG4105CEY Amp-dependent synthetase and ligase HVY52_RS09690 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVY52_RS09695 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY52_RS09700 ENOG4108JA2 transcriptioN-repair coupling factor HVY52_RS09705 ENOG4105IQC Inner membrane protein YcfT HVY52_RS09710 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY52_RS09715 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVY52_RS09720 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY52_RS09730 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVY52_RS09745 ENOG4107RUE extracellular solute-binding protein family 1 HVY52_RS09750 ENOG4105D38 putrescine abc transporter HVY52_RS09755 ENOG4108I1J Integrase HVY52_RS09770 ENOG4106G8A Qin prophage HVY52_RS09810 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HVY52_RS09820 ENOG4105WPN DNA integration recombination invertion protein HVY52_RS09840 ENOG4108MXB Protein of unknown function (DUF968) HVY52_RS09845 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVY52_RS09875 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY52_RS09905 ENOG4105E5H Transposase HVY52_RS09910 ENOG4108YXQ IS66 Orf2 family protein HVY52_RS09935 ENOG4105EFC phage portal protein HK97 family HVY52_RS10030 ENOG4108X9F tail fiber protein HVY52_RS10035 ENOG4105UZW Tail fiber assembly protein HVY52_RS10055 ENOG4105DSB aldose 1-epimerase HVY52_RS10070 ENOG4105VUT cytoplasmic protein HVY52_RS10075 ENOG4108RWI nicotinamidase HVY52_RS10080 ENOG4105HDK L-asparaginase HVY52_RS10090 ENOG4105D07 Signal peptide peptidase, SppA HVY52_RS10095 ENOG41069NU Nitroreductase HVY52_RS10105 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY52_RS10110 ENOG4105F7F Chaperone HVY52_RS10120 ENOG4105D82 Glutamate dehydrogenase HVY52_RS10125 ENOG4105MTM Protein of unknown function (DUF1496) HVY52_RS10130 ENOG4105M6F mutator MutT protein HVY52_RS10135 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVY52_RS10140 ENOG4107RM6 sulfurtransferase HVY52_RS10145 ENOG4108VGW abc transporter atp-binding protein HVY52_RS10150 ENOG4105CXZ ABC transporter, permease HVY52_RS10155 ENOG4105VNH ABC transporter solute-binding protein HVY52_RS10160 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY52_RS10165 ENOG4108N5C SNARE associated Golgi protein-related protein HVY52_RS10170 ENOG4108RSN SNARE associated Golgi HVY52_RS10175 ENOG4105CGK Exodeoxyribonuclease III HVY52_RS10205 ENOG4108SPG Periplasmic Protein HVY52_RS10215 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVY52_RS10225 ENOG4105KKI DNA-binding transcriptional activator OsmE HVY52_RS10230 ENOG4105VZJ PTS System HVY52_RS10235 ENOG4105CK1 PTS System HVY52_RS10240 ENOG4105VCP PTS System HVY52_RS10245 ENOG4105EZV Transcriptional regulator HVY52_RS10250 ENOG4105F8D glycoside hydrolase family 4 HVY52_RS10260 ENOG4105CH6 catalase HVY52_RS10265 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HVY52_RS10270 ENOG4108ETY sodium dicarboxylate symporter HVY52_RS10275 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVY52_RS10280 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVY52_RS10285 ENOG4107PN8 YfeABCD locus regulator HVY52_RS10295 ENOG4105P10 Uncharacterized protein ydiZ HVY52_RS10300 ENOG4105DE4 1-phosphofructokinase HVY52_RS10305 ENOG4108NE3 Salt-induced outer membrane protein HVY52_RS10320 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVY52_RS10325 ENOG41082NX 50s ribosomal protein l35 HVY52_RS10380 ENOG4107RNI Glucose 6-phosphate dehydrogenase effector OpcA HVY52_RS10425 ENOG4105UZW Tail fiber assembly protein HVY52_RS10435 ENOG410685N tail fiber protein HVY52_RS10515 ENOG4105ED4 portal protein HVY52_RS10525 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HVY52_RS10585 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY52_RS10600 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HVY52_RS10605 ENOG4108QBX (LipO)protein HVY52_RS10625 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY52_RS10635 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVY52_RS10640 ENOG4105SUA Ydil protein HVY52_RS10650 ENOG4105IPI Membrane HVY52_RS10655 ENOG4105CQB FAD linked oxidase domain protein HVY52_RS10660 ENOG4105KA0 thioesterase Superfamily protein HVY52_RS10665 ENOG410671Z uncharacterized protein ydiH HVY52_RS10670 ENOG4108Z4V iron-sulfur cluster assembly HVY52_RS10675 ENOG4105DIW FeS assembly protein SUFB HVY52_RS10680 ENOG4105C3K feS assembly ATPase SufC HVY52_RS10685 ENOG4105JRK feS assembly protein SufD HVY52_RS10700 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY52_RS10705 ENOG4105KMX major outer membrane lipoprotein HVY52_RS10710 ENOG4105CA9 Pyruvate kinase HVY52_RS10720 ENOG4105RFR Protein of unknown function (DUF2767) HVY52_RS10725 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVY52_RS10730 ENOG4105N0V mono-oxygenase ydhR HVY52_RS10750 ENOG4108R6K riboflavin synthase, subunit alpha HVY52_RS10755 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVY52_RS10760 ENOG4105CZQ inner membrane transport protein YdhC HVY52_RS10765 ENOG4105F52 Transcriptional regulator HVY52_RS10780 ENOG4105F27 Major Facilitator HVY52_RS10785 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY52_RS10790 ENOG4105K4H Nlp p60 protein HVY52_RS10795 ENOG4105M2J Glutaredoxin HVY52_RS10800 ENOG4107QRT dEAD DEAH box helicase HVY52_RS10805 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HVY52_RS10810 ENOG4108UYE Lactoylglutathione lyase HVY52_RS10815 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY52_RS10820 ENOG4108WUH Transcriptional regulator, TetR family HVY52_RS10825 ENOG4105XZD Fe-S protein HVY52_RS10830 ENOG4107RGM aldo keto reductase HVY52_RS10835 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY52_RS10840 ENOG4105DSW Fusaric acid resistance protein HVY52_RS10845 ENOG4105Y49 secretion protein, HlyD family HVY52_RS10860 ENOG4108XTF Outer Membrane Lipoprotein HVY52_RS10870 ENOG410642K Lysozyme inhibitor HVY52_RS10885 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVY52_RS10890 ENOG4108K3A Glutathione S-transferase HVY52_RS10895 ENOG4105DUX Transporter HVY52_RS10900 ENOG4105CSM endonuclease III HVY52_RS10910 ENOG4108UQQ Electron transport complex HVY52_RS10935 ENOG4105M9B inner membrane protein ydgK HVY52_RS10940 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVY52_RS10945 ENOG4106C6R beta-lactam resistance protein HVY52_RS10950 ENOG4105D9R oxidoreductase HVY52_RS10960 ENOG4105C87 Aminotransferase class I and II HVY52_RS10965 ENOG4106J39 exported protein HVY52_RS10970 ENOG4105EIP mannose-6-phosphate isomerase HVY52_RS10975 ENOG4107GFK fumarate HVY52_RS10980 ENOG4105C9Q fumarate hydratase class II HVY52_RS10990 ENOG4105JJR Histidine kinase HVY52_RS10995 ENOG4107EXC regulatoR HVY52_RS11000 ENOG4105RA2 Membrane HVY52_RS11010 ENOG4105D5Q Arginine ornithine antiporter HVY52_RS11015 ENOG4105C5D exported protein HVY52_RS11020 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY52_RS11025 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY52_RS11030 ENOG4105BZU Histidine kinase HVY52_RS11035 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVY52_RS11050 ENOG4105D94 Major Facilitator Superfamily HVY52_RS11055 ENOG4106NZI LysR family Transcriptional regulator HVY52_RS11060 ENOG4105DAG ROK family HVY52_RS11065 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY52_RS11070 ENOG4105CMQ Chloride channel HVY52_RS11075 ENOG4108IJ8 ABC transporter HVY52_RS11080 ENOG4105E90 ABC transporter HVY52_RS11085 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVY52_RS11090 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HVY52_RS11095 ENOG4105R71 cytoplasmic protein HVY52_RS11100 ENOG4108T9Y Inner membrane protein ydcZ HVY52_RS11105 ENOG4108Z7F N-acetyltransferase HVY52_RS11110 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVY52_RS11115 ENOG4108WYP Transcriptional regulator HVY52_RS11120 ENOG4105CHB tonB-dependent Receptor HVY52_RS11125 ENOG4108NS2 receptor HVY52_RS11130 ENOG4105C85 amino acid HVY52_RS11135 ENOG4108N27 Glutathione S-transferase HVY52_RS11160 ENOG410600T transposase HVY52_RS11225 ENOG4105JAB phenazine biosynthesis protein, phzf family HVY52_RS11230 ENOG4105DIA mandelate racemase muconate lactonizing HVY52_RS11245 ENOG4108MEJ flavin reductase domain protein HVY52_RS11250 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVY52_RS11255 ENOG4107HP6 Transcriptional regulator HVY52_RS11260 ENOG4105DTQ mandelate racemase muconate lactonizing HVY52_RS11265 ENOG4105NN7 muconolactone delta-isomerase HVY52_RS11270 ENOG410626B catechol 1,2-dioxygenase HVY52_RS11305 ENOG4105RPH Inner membrane protein YddG HVY52_RS11315 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY52_RS11320 ENOG4108MG3 formate dehydrogenase HVY52_RS11325 ENOG41084S7 Plasmid maintenance system antidote protein HVY52_RS11335 ENOG4105DQ4 alcohol dehydrogenase HVY52_RS11345 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVY52_RS11350 ENOG4105TPS biofilm-dependent modulation protein HVY52_RS11355 ENOG4108Z9K Osmotically inducible protein HVY52_RS11365 ENOG4105DDW LysR family Transcriptional regulator HVY52_RS11370 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HVY52_RS11375 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HVY52_RS11380 ENOG4105E32 cytoplasmic protein HVY52_RS11390 ENOG4105Z2P Protein of unknown function (DUF465) HVY52_RS11395 ENOG4108Z9I -acetyltransferase HVY52_RS11400 ENOG4107WE3 acetyltransferase YdcK HVY52_RS11405 ENOG41088CC tellurite resistance protein tehB HVY52_RS11410 ENOG4108KKZ (LipO)protein HVY52_RS11415 ENOG4105CFP Peptidase U32 HVY52_RS11425 ENOG4105RR0 Protein of unknown function (DUF2554) HVY52_RS11430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY52_RS11435 ENOG4107TYH extracellular solute-binding protein family 1 HVY52_RS11440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY52_RS11445 ENOG4105D81 ABC transporter, permease HVY52_RS11450 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVY52_RS11465 ENOG410654E Membrane HVY52_RS11470 ENOG4105KBG Protein of unknown function (DUF1161) HVY52_RS11480 ENOG4108MK9 spermidine N(1)-acetyltransferase HVY52_RS11495 ENOG4105CXK mandelate racemase muconate lactonizing HVY52_RS11500 ENOG4105CPQ Dehydrogenase HVY52_RS11505 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVY52_RS11515 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY52_RS11520 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVY52_RS11525 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY52_RS11535 ENOG4105DEI Mannitol dehydrogenase HVY52_RS11540 ENOG41061EV selenium-binding protein YdfZ HVY52_RS11545 ENOG4107XBN GntR Family Transcriptional Regulator HVY52_RS11550 ENOG4105EMU Dehydrogenase HVY52_RS11555 ENOG4105DGW oligopeptidase A HVY52_RS11560 ENOG4108WTK competence damage-inducible protein HVY52_RS11565 ENOG4108YDI single-species biofilm formation on inanimate substrate HVY52_RS11570 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVY52_RS11575 ENOG4105E5W Transporter HVY52_RS11580 ENOG4108594 Permease of the drug metabolite transporter HVY52_RS11585 ENOG4106DNR multiple antibiotic resistance protein HVY52_RS11590 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVY52_RS11595 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVY52_RS11610 ENOG4105EGI Transcriptional regulator HVY52_RS11620 ENOG4105C26 Dehydrogenase HVY52_RS11625 ENOG4105CSV Glutaminase HVY52_RS11630 ENOG4105M0C cytoplasmic protein HVY52_RS11635 ENOG4105BZU Histidine kinase HVY52_RS11645 ENOG4105FFC UPF0187 protein HVY52_RS11655 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVY52_RS11675 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HVY52_RS11680 ENOG4105C2J ABC transporter HVY52_RS11690 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HVY52_RS11700 ENOG4108R6W Transcriptional regulator, ARAC family HVY52_RS11705 ENOG4106PHM regulatory protein HVY52_RS11720 ENOG4105CQ0 ABC transporter HVY52_RS11725 ENOG4105PE1 Receptor HVY52_RS11730 ENOG4107RAN Peptidase, M16 HVY52_RS11735 ENOG4105CVK Glutamate decarboxylase HVY52_RS11740 ENOG4105E5D amino acid HVY52_RS11745 ENOG4105F32 YngK protein HVY52_RS11750 ENOG4105BZU Histidine kinase HVY52_RS11755 ENOG4105BZU Histidine kinase HVY52_RS11770 ENOG4105CPW cytochrome b561 HVY52_RS11775 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVY52_RS11780 ENOG4107DB1 DUF218 domain HVY52_RS11790 ENOG4105CQ7 ATP-dependent helicase HVY52_RS11800 ENOG41077RS Phosphatase HVY52_RS11805 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVY52_RS11810 ENOG4108HPI phosphatidate Cytidylyltransferase HVY52_RS11815 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVY52_RS11825 ENOG4107S5I aldo keto reductase HVY52_RS11830 ENOG4108Z0R Transferase HVY52_RS11835 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVY52_RS11840 ENOG4105DZS Phenylacetate-CoA ligase HVY52_RS11845 ENOG4105CHU acetyl-coa acetyltransferase HVY52_RS11850 ENOG4108ZJI phenylacetic acid degradation protein HVY52_RS11855 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVY52_RS11860 ENOG4108UKI Enoyl-CoA hydratase HVY52_RS11865 ENOG4105E39 Enoyl-CoA hydratase HVY52_RS11870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY52_RS11875 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVY52_RS11880 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVY52_RS11885 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVY52_RS11890 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVY52_RS11895 ENOG4105DXM phenylacetic acid degradation protein HVY52_RS11900 ENOG4105F11 amine oxidase HVY52_RS11905 ENOG4105C26 Dehydrogenase HVY52_RS11910 ENOG4108WFR AraC Family Transcriptional Regulator HVY52_RS11920 ENOG4105WXT Conserved Protein HVY52_RS11925 ENOG410689M (LipO)protein HVY52_RS11930 ENOG4107H52 Dicarboxylate transport HVY52_RS11935 ENOG4105C5I Dehydrogenase HVY52_RS11940 ENOG41090X5 Heat shock protein hslJ HVY52_RS11945 ENOG4105IKK cytoplasmic protein HVY52_RS11955 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVY52_RS11960 ENOG4105FCK Membrane HVY52_RS11965 ENOG4108RW8 Universal stress protein F HVY52_RS11975 ENOG4105C1J atp-dependent rna helicase HVY52_RS11990 ENOG4105BZU Histidine kinase HVY52_RS11995 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HVY52_RS12000 ENOG4105F2Z 3-oxoadipate enol-lactonase HVY52_RS12005 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HVY52_RS12010 ENOG4105CHU acetyl-coa acetyltransferase HVY52_RS12015 ENOG4107QNJ CoA-transferase subunit B HVY52_RS12025 ENOG4107HP6 Transcriptional regulator HVY52_RS12030 ENOG4108DG9 Smr protein MutS2 HVY52_RS12035 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY52_RS12040 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVY52_RS12045 ENOG4105Q9Y Universal stress protein HVY52_RS12050 ENOG4105S5I Membrane HVY52_RS12055 ENOG4105D64 Mechanosensitive ion channel HVY52_RS12060 ENOG4107QSI ABC, transporter HVY52_RS12065 ENOG4105KXI murein peptide amidase A HVY52_RS12070 ENOG4107S8C mandelate racemase muconate lactonizing HVY52_RS12075 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVY52_RS12080 ENOG4108JU8 Transcriptional regulator HVY52_RS12090 ENOG4105CM6 amino acid regulated cytosolic protein HVY52_RS12095 ENOG4105FKQ transcriptional regulator HVY52_RS12100 ENOG4107EFV Outer membrane protein G HVY52_RS12105 ENOG4108IJ9 (ABC) transporter HVY52_RS12110 ENOG4107URF beta-phospho-glucomutase HVY52_RS12115 ENOG4105C71 hydrolase family 65, central catalytic HVY52_RS12120 ENOG4105CK5 oxidoreductase HVY52_RS12125 ENOG4107TYA transient receptor potential locus HVY52_RS12130 ENOG4107RRD Dehydrogenase HVY52_RS12135 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HVY52_RS12140 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HVY52_RS12145 ENOG4105WEM extracellular solute-binding protein HVY52_RS12150 ENOG4107QW3 Sucrose phosphorylase HVY52_RS12155 ENOG4105K8Z Phage shock protein HVY52_RS12160 ENOG4105NNG Peripheral inner membrane phage-shock protein HVY52_RS12165 ENOG4105FM1 phage shock protein C HVY52_RS12170 ENOG4105YYT phage shock protein B HVY52_RS12175 ENOG41087YS Phage shock protein A HVY52_RS12180 ENOG4105E51 psp operon transcriptional activator HVY52_RS12185 ENOG4108HIY periplasmic HVY52_RS12190 ENOG4108I5W peptide transport system, permease protein HVY52_RS12195 ENOG4108EU3 peptide transport system, permease HVY52_RS12200 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVY52_RS12205 ENOG4108JQ2 peptide transport system atp-binding protein HVY52_RS12210 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVY52_RS12215 ENOG4105Q4T oxidoreductase HVY52_RS12225 ENOG4105BZU Histidine kinase HVY52_RS12235 ENOG4105N2W Transcriptional regulator HVY52_RS12245 ENOG4108ZJT translation initiation factor, Sui1 HVY52_RS12255 ENOG4105CFV Tetratricopeptide repeat protein HVY52_RS12260 ENOG4105Q4A inner membrane protein yciS HVY52_RS12265 ENOG4105EYK Phosphatidylglycerophosphatase B HVY52_RS12275 ENOG4107QM5 aconitate hydratase HVY52_RS12290 ENOG4107R11 Transcriptional regulator HVY52_RS12295 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY52_RS12300 ENOG4105RKX Protein of unknown function (DUF2498) HVY52_RS12305 ENOG4105ERU peptidase HVY52_RS12310 ENOG4105UBK short-chain dehydrogenase reductase HVY52_RS12315 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVY52_RS12320 ENOG4105FE9 pseudouridine synthase HVY52_RS12325 ENOG4105EG3 transmembrane signal peptide protein HVY52_RS12330 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVY52_RS12335 ENOG4105DB7 PHP domain protein HVY52_RS12345 ENOG4105CRQ synthase (Component I) HVY52_RS12350 ENOG4108EFP Anthranilate synthase component II HVY52_RS12355 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVY52_RS12370 ENOG4105EIF outer membrane protein W HVY52_RS12375 ENOG4105PI0 Ferredoxin HVY52_RS12390 ENOG4105NAU thioesterase Superfamily protein HVY52_RS12395 ENOG410822N TonB family HVY52_RS12400 ENOG4105K9H YciI-like protein HVY52_RS12410 ENOG4105D7V transposase HVY52_RS12425 ENOG4105EYW Ion transport protein HVY52_RS12430 ENOG4108JQ7 (ABC) transporter HVY52_RS12435 ENOG4105C3U ABC transporter HVY52_RS12440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY52_RS12445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY52_RS12450 ENOG4107QSI ABC, transporter HVY52_RS12455 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVY52_RS12460 ENOG4105C0A alcohol dehydrogenase HVY52_RS12465 ENOG4105VNT transposase (IS4 family) protein HVY52_RS12470 ENOG4107104 thymidine kinase HVY52_RS12480 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY52_RS12485 ENOG4105I93 response regulator HVY52_RS12490 ENOG4105D78 K07001 NTE family protein HVY52_RS12500 ENOG4105CIY formyltetrahydrofolate deformylase HVY52_RS12545 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY52_RS12550 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVY52_RS12555 ENOG41076YT nitrate reductase, gamma subunit HVY52_RS12560 ENOG4105R3A Nitrate reductase HVY52_RS12565 ENOG4108IUE nitrate reductase beta subunit HVY52_RS12570 ENOG4105CRU nitrate reductase, alpha subunit HVY52_RS12575 ENOG4105DQQ Major facilitator superfamily MFS_1 HVY52_RS12585 ENOG4105BZU Histidine kinase HVY52_RS12590 ENOG4105WH1 Two component transcriptional regulator luxr family HVY52_RS12595 ENOG4105ID0 Putative invasin HVY52_RS12600 ENOG41090EX DsrE family HVY52_RS12605 ENOG4108NH8 Cation transport protein HVY52_RS12610 ENOG4105WS7 Cation transport regulator HVY52_RS12615 ENOG4105EWV Sodium calcium exchanger membrane region HVY52_RS12630 ENOG41063JG Transcriptional regulator HVY52_RS12635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVY52_RS12660 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVY52_RS12665 ENOG4105CHH sulfate transporter HVY52_RS12670 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVY52_RS12680 ENOG4105C3G gtp-binding protein HVY52_RS12735 ENOG4105E53 ec 3.2.1.28 HVY52_RS12745 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVY52_RS12755 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVY52_RS12765 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY52_RS12775 ENOG4105ED1 spovr family HVY52_RS12790 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVY52_RS12795 ENOG4105TNG K13735 adhesin invasin HVY52_RS12805 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVY52_RS12820 ENOG4107QMS site-determining protein HVY52_RS12830 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY52_RS12835 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY52_RS12840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY52_RS12850 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVY52_RS12870 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVY52_RS12875 ENOG4105CDY transcriptional regulatory protein HVY52_RS12885 ENOG4105TNG K13735 adhesin invasin HVY52_RS12900 ENOG4105JAB phenazine biosynthesis protein, phzf family HVY52_RS12905 ENOG4108I1J Integrase HVY52_RS12910 ENOG4108HMX isocitrate dehydrogenase (NADP) HVY52_RS12915 ENOG4108R99 pseudouridine synthase HVY52_RS12935 ENOG4107QTF adenylosuccinate lyase HVY52_RS12940 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY52_RS12945 ENOG4105IFJ Histidine kinase HVY52_RS12950 ENOG4105EZE Cupin 4 family protein HVY52_RS12955 ENOG4105CV8 reductase HVY52_RS12960 ENOG4105GNX MltA-interacting MipA family protein HVY52_RS12965 ENOG4105CYN Serine protein kinase HVY52_RS12975 ENOG4106KTS Inner membrane protein yeaI HVY52_RS12980 ENOG4108KHP Diguanylate cyclase HVY52_RS12985 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVY52_RS13000 ENOG4105DJ2 Major Facilitator Superfamily HVY52_RS13005 ENOG4105K78 MarR family Transcriptional regulator HVY52_RS13010 ENOG4105UCG Domain of unknown function (DUF333) HVY52_RS13015 ENOG410620I Diguanylate cyclase HVY52_RS13020 ENOG4106G4W HVY52_RS13030 ENOG4105Y3U Transglycosylase-associated protein HVY52_RS13040 ENOG4107MBR 17 kDa surface antigen HVY52_RS13045 ENOG4105CEP NADH dehydrogenase HVY52_RS13060 ENOG4108RUM thiamine kinase HVY52_RS13065 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVY52_RS13070 ENOG41090DQ Lipoprotein HVY52_RS13075 ENOG4105K59 histidine triad (HIT) protein HVY52_RS13080 ENOG4105CI1 PTS System HVY52_RS13085 ENOG4105F8V Hydrolase, tatD family HVY52_RS13090 ENOG4107QRG dna polymerase iii HVY52_RS13100 ENOG4105HHA aminodeoxychorismate lyase HVY52_RS13105 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVY52_RS13110 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY52_RS13115 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVY52_RS13120 ENOG4105CHR reductase HVY52_RS13125 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVY52_RS13130 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVY52_RS13140 ENOG4105VGS 50s ribosomal protein l32 HVY52_RS13145 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVY52_RS13150 ENOG4108UHJ MAF-like protein HVY52_RS13155 ENOG4105EI2 Pseudouridine synthase HVY52_RS13160 ENOG4107QQB Ribonuclease E HVY52_RS13165 ENOG4105DTJ flagellar hook-associated protein HVY52_RS13170 ENOG4105E1Q flagellar hook-associated protein HVY52_RS13175 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVY52_RS13190 ENOG4105CGA flagellar basal-body rod protein FlgG HVY52_RS13195 ENOG4108KPB Flagellar basal-body rod protein FlgF HVY52_RS13200 ENOG4105BZE flagellar hook protein, FlgE HVY52_RS13205 ENOG4105W00 Flagellar hook capping protein HVY52_RS13210 ENOG4108ZC9 flagellar basal-body rod protein flgc HVY52_RS13215 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVY52_RS13220 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVY52_RS13225 ENOG4105M9M anti-sigma28 factor FlgM HVY52_RS13230 ENOG4105QVD Flagella synthesis protein FlgN HVY52_RS13235 ENOG4105CJR Integral membrane protein (MviN HVY52_RS13240 ENOG4105EP9 oxidoreductase HVY52_RS13250 ENOG4105D9U N-acetyltransferase HVY52_RS13260 ENOG4105F3T (LipO)protein HVY52_RS13270 ENOG4105MEA DNA damage-inducible protein i HVY52_RS13275 ENOG4105PVA Biofilm formation regulatory protein BssS HVY52_RS13285 ENOG4105DS1 cytochrome b561 HVY52_RS13290 ENOG4108YYC ycei family HVY52_RS13300 ENOG4105D1S lipid A biosynthesis HVY52_RS13310 ENOG4108W47 Acidic protein msyB HVY52_RS13315 ENOG4105NAC (LipO)protein HVY52_RS13320 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVY52_RS13330 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HVY52_RS13335 ENOG4107RZC phospholipase d HVY52_RS13350 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HVY52_RS13355 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVY52_RS13360 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVY52_RS13365 ENOG41086KC Transcriptional regulator HVY52_RS13370 ENOG4108XDW curli assembly protein CsgE HVY52_RS13375 ENOG4108WYR Curli production assembly transport component, CsgF HVY52_RS13380 ENOG4105P8Q Curli production assembly transport component CsgG HVY52_RS13385 ENOG4108UQ5 membrane protein YcdZ HVY52_RS13390 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVY52_RS13410 ENOG4105CRK lysyL-tRNA synthetase HVY52_RS13415 ENOG4105DUX Transporter HVY52_RS13420 ENOG4105CXN decarboxylase HVY52_RS13425 ENOG4105D5Q Arginine ornithine antiporter HVY52_RS13430 ENOG4108M3R transcriptional activator CadC HVY52_RS13435 ENOG4105BZU Histidine kinase HVY52_RS13440 ENOG4108TUY outer membrane protein PgaA HVY52_RS13445 ENOG4107BJW polysaccharide deacetylase HVY52_RS13450 ENOG4105CND Glycosyl transferase, family 2 HVY52_RS13460 ENOG4105D5M phosphate starvation-inducible protein HVY52_RS13465 ENOG4105DBE peroxidase HVY52_RS13470 ENOG410650H (LipO)protein HVY52_RS13480 ENOG4105CK7 Sodium proline symporter HVY52_RS13490 ENOG4105C26 Dehydrogenase HVY52_RS13495 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVY52_RS13500 ENOG4108MJ5 VirK protein HVY52_RS13505 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HVY52_RS13510 ENOG4107BJW polysaccharide deacetylase HVY52_RS13515 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVY52_RS13520 ENOG4105KT5 UmuD protein HVY52_RS13530 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVY52_RS13535 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY52_RS13540 ENOG41090PJ Flagellar assembly protein HVY52_RS13545 ENOG4108JIR Flagellum-specific ATP synthase HVY52_RS13550 ENOG4105GSA Flagellar export protein flij HVY52_RS13555 ENOG4105WF4 Flagellar hook-length control protein HVY52_RS13560 ENOG4107ZI8 flagellar basal body-associated protein flil HVY52_RS13565 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY52_RS13570 ENOG4105DD5 Flagellar motor switch protein HVY52_RS13575 ENOG4105K0P flagellar biosynthesis protein HVY52_RS13580 ENOG4105CN7 Flagellar biosynthetic protein FliP HVY52_RS13585 ENOG4105VS8 Flagellar biosynthetic protein fliq HVY52_RS13590 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVY52_RS13595 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVY52_RS13605 ENOG4105YX3 cellular response to acidity HVY52_RS13620 ENOG4105VNZ cytoplasmic protein HVY52_RS13625 ENOG4105CKW Inner membrane protein yedI HVY52_RS13630 ENOG4105FDR Membrane HVY52_RS13635 ENOG41090BB DNA mismatch endonuclease (vsr) HVY52_RS13640 ENOG4105EST Metal Dependent Phosphohydrolase HVY52_RS13645 ENOG4105Y0K Inner membrane protein YedR HVY52_RS13650 ENOG4105ZIT Porin Gram-negative type HVY52_RS13660 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY52_RS13685 ENOG4107R11 Transcriptional regulator HVY52_RS13740 ENOG4105GMB type VI secretion system effector, hcp1 family HVY52_RS13765 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY52_RS13815 ENOG4108WC9 type VI secretion system effector, hcp1 family HVY52_RS13820 ENOG4105CS6 Rhs element vgr protein HVY52_RS13860 ENOG4105FYV Amp nucleosidase HVY52_RS13865 ENOG4105CSH Transporter HVY52_RS13875 ENOG4105UQX Mate efflux family protein HVY52_RS13900 ENOG4105KNY Microcompartments protein HVY52_RS13905 ENOG4105KNY Microcompartments protein HVY52_RS13910 ENOG4105KNY Microcompartments protein HVY52_RS13915 ENOG4105C0A alcohol dehydrogenase HVY52_RS13925 ENOG4105C0A alcohol dehydrogenase HVY52_RS13930 ENOG4105C6N Formate acetyltransferase HVY52_RS13935 ENOG4105F1A Pyruvate formate-lyase HVY52_RS13940 ENOG4105KNY Microcompartments protein HVY52_RS13945 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVY52_RS13965 ENOG4108PXI ErfK YbiS YcfS YnhG HVY52_RS13970 ENOG4108P62 biosynthesis protein (CbiG) HVY52_RS13980 ENOG4107XVH Transcriptional regulator HVY52_RS13985 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY52_RS13990 ENOG4105KNY Microcompartments protein HVY52_RS13995 ENOG4105EHR propanediol utilization protein pduB HVY52_RS14000 ENOG4105DMB glycerol dehydratase HVY52_RS14005 ENOG4105YCI dehydratase medium subunit HVY52_RS14010 ENOG4108ZFT Dehydratase small subunit HVY52_RS14015 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVY52_RS14025 ENOG4105KNY Microcompartments protein HVY52_RS14045 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVY52_RS14055 ENOG4108EKI Dehydrogenase HVY52_RS14065 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVY52_RS14075 ENOG4105M3W utilization protein HVY52_RS14080 ENOG4105KTW ethanolamine utilization protein HVY52_RS14095 ENOG4105DR8 Membrane HVY52_RS14105 ENOG4105CJB Exodeoxyribonuclease I HVY52_RS14115 ENOG4105CUC YeeE YedE family protein HVY52_RS14120 ENOG4105CUB amino acid HVY52_RS14130 ENOG4105EQ1 Transcriptional regulator HVY52_RS14135 ENOG4107SRH Nad-dependent epimerase dehydratase HVY52_RS14140 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVY52_RS14145 ENOG4105VTW prevent-host-death family HVY52_RS14160 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVY52_RS14170 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVY52_RS14175 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVY52_RS14205 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVY52_RS14235 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVY52_RS14240 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY52_RS14245 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVY52_RS14250 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY52_RS14255 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY52_RS14260 ENOG4105DMT epimerase dehydratase HVY52_RS14265 ENOG4105G1A colanic acid biosynthesis protein HVY52_RS14270 ENOG4107T8Q Glycosyl transferase (Group 1 HVY52_RS14275 ENOG4105C74 pyruvyl transferase HVY52_RS14280 ENOG4105PSV Polysaccharide Biosynthesis Protein HVY52_RS14285 ENOG4105D3Q Sugar transferase HVY52_RS14290 ENOG4107QKV phosphomannomutase HVY52_RS14295 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVY52_RS14300 ENOG4106CD9 glycosyl transferase group 1 HVY52_RS14305 ENOG4105FGF GDP-mannose mannosyl hydrolase HVY52_RS14310 ENOG4105C30 Nad-dependent epimerase dehydratase HVY52_RS14315 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVY52_RS14320 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVY52_RS14325 ENOG4105ECJ Glycosyl Transferase HVY52_RS14330 ENOG4108NYJ Colanic acid HVY52_RS14335 ENOG4107RXY Glycosyl transferase HVY52_RS14340 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVY52_RS14345 ENOG41090RK glycosyl transferase HVY52_RS14350 ENOG4105D75 Capsular exopolysaccharide family HVY52_RS14355 ENOG4105KJF protein tyrosine phosphatase HVY52_RS14360 ENOG4105DAY polysaccharide export protein HVY52_RS14365 ENOG4105EE5 Membrane protein terC HVY52_RS14380 ENOG4108GAE asmA family HVY52_RS14395 ENOG4105BZU Histidine kinase HVY52_RS14400 ENOG4105D03 DNA-3-methyladenine glycosylase II HVY52_RS14405 ENOG4105R8A Heat shock protein HVY52_RS14410 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVY52_RS14415 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HVY52_RS14420 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVY52_RS14425 ENOG4108M24 von Willebrand factor, type A HVY52_RS14445 ENOG4105UZW Tail fiber assembly protein HVY52_RS14450 ENOG410685N tail fiber protein HVY52_RS14555 ENOG4105QYK bacteriophage lambda Bor protein homolog HVY52_RS14565 ENOG4105KUS lysozyme HVY52_RS14570 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY52_RS14575 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HVY52_RS14580 ENOG4107SEY Conserved Protein HVY52_RS14590 ENOG4105HRS Antitermination protein HVY52_RS14605 ENOG4105RWQ Protein of unknown function (DUF1364) HVY52_RS14610 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVY52_RS14615 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVY52_RS14750 ENOG4108I1J Integrase HVY52_RS14775 ENOG4105EB3 Histidine kinase HVY52_RS14780 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY52_RS14785 ENOG4105KWI UPF0339 protein HVY52_RS14790 ENOG4105CFP Peptidase U32 HVY52_RS14800 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVY52_RS14805 ENOG4105IE8 Alpha-ketoglutarate permease HVY52_RS14810 ENOG4105CMG Carbohydrate kinase HVY52_RS14815 ENOG4105DEI Mannitol dehydrogenase HVY52_RS14835 ENOG4105EF1 ribulokinase HVY52_RS14840 ENOG4105IE8 Alpha-ketoglutarate permease HVY52_RS14845 ENOG4105EIE fructose-bisphosphate aldolase HVY52_RS14850 ENOG4105EAA nucleoside HVY52_RS14855 ENOG4108KD5 ADP-ribosylation crystallin J1 HVY52_RS14860 ENOG4108TFM Kinase, PfkB family HVY52_RS14865 ENOG4105FDP GntR family transcriptional regulator HVY52_RS14870 ENOG4108UQ1 hydrolase, family 25 HVY52_RS14875 ENOG4105DWF phosphomethylpyrimidine kinase HVY52_RS14885 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVY52_RS14890 ENOG410662B Type-1 fimbrial protein HVY52_RS14895 ENOG4105CW0 outer membrane usher protein HVY52_RS14900 ENOG4108MQF Chaperone HVY52_RS14910 ENOG41067AK Protein of unknown function (DUF2574) HVY52_RS14915 ENOG4105D1F ATP-binding protein HVY52_RS14925 ENOG4108KDT Molybdate metabolism regulator HVY52_RS14930 ENOG4108KDT Molybdate metabolism regulator HVY52_RS14935 ENOG4108KDT Molybdate metabolism regulator HVY52_RS14945 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVY52_RS14950 ENOG4105RD5 HVY52_RS14955 ENOG4105DEG Vwa containing coxe family protein HVY52_RS14960 ENOG410903U zinc ion binding HVY52_RS14965 ENOG4108YCW (LipO)protein HVY52_RS14970 ENOG4108W15 Protein of unknown function (DUF1456) HVY52_RS14975 ENOG4108NEV two component transcriptional regulator, LytTR family HVY52_RS14980 ENOG4108HRK Histidine kinase HVY52_RS14985 ENOG4108XDN Transcriptional regulator HVY52_RS14995 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVY52_RS15000 ENOG4108IJ8 ABC transporter HVY52_RS15005 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVY52_RS15010 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVY52_RS15015 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVY52_RS15020 ENOG4105CXG d-lactate dehydrogenase HVY52_RS15025 ENOG41061WM D-Alanyl-D-Alanine HVY52_RS15030 ENOG41069YE inner membrane protein yohC HVY52_RS15035 ENOG4105KHU inner membrane protein YohD HVY52_RS15040 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVY52_RS15050 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVY52_RS15060 ENOG41067MG lrgb family HVY52_RS15070 ENOG4107GZ4 SanA protein HVY52_RS15075 ENOG4105Y9N Membrane HVY52_RS15080 ENOG4105BZ8 glutamate synthase HVY52_RS15085 ENOG4107SJI Dehydrogenase HVY52_RS15090 ENOG4108HWV )-transporter HVY52_RS15095 ENOG4105C2J ABC transporter HVY52_RS15100 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVY52_RS15105 ENOG41060NJ transcriptional regulator HVY52_RS15110 ENOG4105DHF Membrane HVY52_RS15125 ENOG4105D05 Receptor HVY52_RS15130 ENOG4108IQI permease HVY52_RS15135 ENOG4105DUM transcriptional regulator, lysR family HVY52_RS15140 ENOG4105HMI Membrane HVY52_RS15150 ENOG4105DD7 kinase (PfkB family HVY52_RS15155 ENOG4105D9N nucleoside HVY52_RS15165 ENOG4108Y4K DNA-binding transcriptional activator HVY52_RS15170 ENOG4105D9N nucleoside HVY52_RS15175 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVY52_RS15180 ENOG4105DD7 kinase (PfkB family HVY52_RS15185 ENOG4105DM4 PTS System HVY52_RS15190 ENOG4105DE4 1-phosphofructokinase HVY52_RS15195 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVY52_RS15200 ENOG4105S8Q sugar efflux transporter HVY52_RS15205 ENOG4105KRS Proteinase inhibitor HVY52_RS15215 ENOG4105DEI Mannitol dehydrogenase HVY52_RS15220 ENOG4105CKI cobalamin synthesis protein HVY52_RS15225 ENOG41076MN Phosphoesterase, PA-phosphatase related HVY52_RS15230 ENOG4107TT5 NLP P60 protein HVY52_RS15235 ENOG4105CXC rtn protein HVY52_RS15240 ENOG4105E43 Extracellular solute-binding protein, family 5 HVY52_RS15245 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVY52_RS15250 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVY52_RS15255 ENOG4108JQ5 ABC transporter HVY52_RS15260 ENOG4105HG6 HVY52_RS15265 ENOG4105C2C drug resistance transporter, Bcr CflA HVY52_RS15270 ENOG4105I08 Pseudouridine synthase HVY52_RS15275 ENOG4105CFI type iii restriction protein res subunit HVY52_RS15300 ENOG4105E68 Sulfatase HVY52_RS15310 ENOG4105DFP Integrase HVY52_RS15365 ENOG410658X HVY52_RS15370 ENOG4105WH1 Two component transcriptional regulator luxr family HVY52_RS15375 ENOG4105KWW Biogenesis protein HVY52_RS15380 ENOG4107QX9 Thiol disulfide interChange protein HVY52_RS15385 ENOG4105DA4 cytochrome c-type biogenesis protein HVY52_RS15395 ENOG4105X3C heme exporter protein HVY52_RS15400 ENOG41060IM Heme exporter protein HVY52_RS15405 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVY52_RS15415 ENOG4105CUW cytochrome C-TYPE protein HVY52_RS15420 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVY52_RS15425 ENOG4105GXZ Ferredoxin-type protein NapH HVY52_RS15430 ENOG4108BGM Quinol dehydrogenase periplasmic component HVY52_RS15440 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVY52_RS15445 ENOG4108ZNS ferredoxin-type protein NapF HVY52_RS15455 ENOG4105D8X mechanosensitive ion channel HVY52_RS15465 ENOG4105ZY9 UPF0379 protein ybiM HVY52_RS15470 ENOG4108IU3 tonb-dependent siderophore receptor HVY52_RS15480 ENOG4105KSC Transcriptional regulator, TraR DksA family HVY52_RS15485 ENOG4105VR4 UPF0379 protein ybiJ HVY52_RS15490 ENOG4105DG4 malate L-lactate dehydrogenase HVY52_RS15495 ENOG4108MTB glycosyl transferase family HVY52_RS15500 ENOG4105DVT helicase HVY52_RS15505 ENOG4108UV1 cellular component movement HVY52_RS15510 ENOG4105C1J atp-dependent rna helicase HVY52_RS15515 ENOG4107MVR Transcriptional regulator HVY52_RS15525 ENOG4105CJ1 ABC, transporter HVY52_RS15530 ENOG4107QWP ABC-2 type transporter HVY52_RS15535 ENOG4107QWP ABC-2 type transporter HVY52_RS15540 ENOG4105I9U inner membrane protein ybhQ HVY52_RS15545 ENOG4105X23 Endonuclease Exonuclease phosphatase HVY52_RS15550 ENOG4105DZQ phospholipase D Transphosphatidylase HVY52_RS15555 ENOG4107UXM Membrane HVY52_RS15560 ENOG410733J conserved inner membrane protein HVY52_RS15565 ENOG4105DIJ Phosphoethanolamine transferase HVY52_RS15570 ENOG4105HFZ Membrane HVY52_RS15575 ENOG4108ZAF Molybdopterin HVY52_RS15580 ENOG4105M00 molybdopterin converting factor, subunit 1 HVY52_RS15590 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY52_RS15600 ENOG4105CHW UPF0052 protein HVY52_RS15610 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY52_RS15615 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVY52_RS15630 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVY52_RS15635 ENOG4108V1U phospholipid-binding protein HVY52_RS15640 ENOG4105NBR Pectinesterase HVY52_RS15650 ENOG4108K4B hydrolase HVY52_RS15660 ENOG4105E0C molybdate abc transporter HVY52_RS15665 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVY52_RS15675 ENOG4105F4R Transcriptional regulator mode HVY52_RS15680 ENOG4105DKW ABC transporter HVY52_RS15685 ENOG4105CMR udp-glucose 4-epimerase HVY52_RS15690 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVY52_RS15700 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVY52_RS15710 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY52_RS15715 ENOG4105JND homeobox protein HVY52_RS15720 ENOG4105PGM cation diffusion facilitator family transporter HVY52_RS15725 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY52_RS15775 ENOG4105UFD tol-pal system protein YbgF HVY52_RS15780 ENOG4105KCK Peptidoglycan-associated lipoprotein HVY52_RS15790 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVY52_RS15800 ENOG4105E02 MotA TolQ exbB proton channel HVY52_RS15805 ENOG4107YD3 Thioesterase HVY52_RS15810 ENOG4105KJB cyd operon protein YbgE HVY52_RS15820 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY52_RS15825 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY52_RS15830 ENOG4105C8I hydrolase, family 38 HVY52_RS15835 ENOG4105DM4 PTS System HVY52_RS15840 ENOG4105FDP GntR family transcriptional regulator HVY52_RS15845 ENOG4107WFU Glutamate mutase subunit sigma HVY52_RS15855 ENOG4105DJI Methylaspartate mutase, E subunit HVY52_RS15880 ENOG4107GFK fumarate HVY52_RS15885 ENOG4105ETT transcriptional Regulator, LysR family HVY52_RS15890 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVY52_RS15900 ENOG4105C7S Dehydrogenase HVY52_RS15905 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVY52_RS15910 ENOG4105E33 succinate dehydrogenase HVY52_RS15915 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY52_RS15920 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVY52_RS15925 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVY52_RS15930 ENOG4105BZN citrate synthase HVY52_RS15945 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY52_RS15955 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY52_RS15960 ENOG4105CTX dehydratase HVY52_RS15970 ENOG4105CHR reductase HVY52_RS15975 ENOG4105CPQ Dehydrogenase HVY52_RS15980 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVY52_RS15985 ENOG41073TP transcriptional regulator HVY52_RS15990 ENOG4106UBK fimbrial-like adhesin protein HVY52_RS15995 ENOG4106PG1 outer membrane usher protein HVY52_RS16000 ENOG4108TTM chaperone HVY52_RS16005 ENOG4108MY7 Fimbrial HVY52_RS16010 ENOG4108KK1 membrane protein AbrB duplication HVY52_RS16035 ENOG4107R7A Allophanate hydrolase subunit 2 HVY52_RS16040 ENOG4105P4J Allophanate hydrolase, subunit 1 HVY52_RS16045 ENOG4107QNR UPF0135 protein HVY52_RS16050 ENOG4105DUX Transporter HVY52_RS16055 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVY52_RS16060 ENOG4107SEY Conserved Protein HVY52_RS16090 ENOG4105XIQ Protein of unknown function (DUF2517) HVY52_RS16115 ENOG4105C08 Histidine kinase HVY52_RS16120 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVY52_RS16125 ENOG4105CXN decarboxylase HVY52_RS16130 ENOG4105D5Q Arginine ornithine antiporter HVY52_RS16135 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVY52_RS16140 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVY52_RS16145 ENOG4105EV9 Alpha Beta Hydrolase HVY52_RS16150 ENOG4105NNH LexA regulated protein HVY52_RS16155 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVY52_RS16165 ENOG41090R7 Ferric uptake HVY52_RS16170 ENOG4105GX6 (LipO)protein HVY52_RS16185 ENOG4105CI1 PTS System HVY52_RS16195 ENOG4105CE4 GlcNAc 6-P deacetylase HVY52_RS16200 ENOG4105E2R ROK family HVY52_RS16205 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVY52_RS16210 ENOG4105CAQ asparagine synthetase HVY52_RS16260 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY52_RS16270 ENOG4105C9A Phoh family HVY52_RS16280 ENOG4108JU5 Magnesium and cobalt efflux protein HVY52_RS16285 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVY52_RS16290 ENOG4107U91 Rhomboid family HVY52_RS16295 ENOG4107RP9 extracellular solute-binding protein, family 3 HVY52_RS16300 ENOG4105EAD ABC transporter HVY52_RS16305 ENOG4105DRP amino acid AbC transporter HVY52_RS16310 ENOG4105CDA abc transporter atp-binding protein HVY52_RS16320 ENOG4105F7F Chaperone HVY52_RS16325 ENOG4105QFC Hsc56 co-chaperone of HscC HVY52_RS16330 ENOG41069CF Protein of unknown function (DUF1266) HVY52_RS16335 ENOG4107JFD Sel1 repeat HVY52_RS16340 ENOG4105QFC Hsc56 co-chaperone of HscC HVY52_RS16345 ENOG41069CF Protein of unknown function (DUF1266) HVY52_RS16350 ENOG4105EUU Sel1 domain protein repeat-containing protein HVY52_RS16355 ENOG4107PAI alpha helical protein HVY52_RS16370 ENOG4105DJF DNA polymerase III, delta' subunit HVY52_RS16380 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVY52_RS16390 ENOG4105CJN penicillin-binding protein HVY52_RS16395 ENOG4105CNI cell division protein FtsW HVY52_RS16400 ENOG4105K6T rare lipoprotein A HVY52_RS16405 ENOG4105DZ1 carboxypeptidase HVY52_RS16415 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HVY52_RS16445 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVY52_RS16450 ENOG4105CEE C4-dicarboxylate transporter HVY52_RS16455 ENOG4105KTS ribonuclease HVY52_RS16460 ENOG4105NXH GreA GreB family elongation factor HVY52_RS16465 ENOG4108U51 Universal stress protein HVY52_RS16470 ENOG4108JU3 Alkyl hydroperoxide reductase HVY52_RS16475 ENOG4105D3R alkyl hydroperoxide reductase HVY52_RS16480 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVY52_RS16485 ENOG4105DQS Transcriptional regulator HVY52_RS16490 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVY52_RS16495 ENOG4105GTN ParB Domain Protein Nuclease HVY52_RS16500 ENOG4105CHM Aminotransferase HVY52_RS16505 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVY52_RS16510 ENOG4105VCD cytoplasmic protein HVY52_RS16515 ENOG4105D22 carbon starvation protein HVY52_RS16520 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVY52_RS16525 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVY52_RS16530 ENOG4105WQI isochorismatase HVY52_RS16535 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVY52_RS16540 ENOG4105E4F Isochorismate synthase HVY52_RS16545 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVY52_RS16555 ENOG4105DQ5 transport system permease protein HVY52_RS16560 ENOG4105TVJ transport system, permease HVY52_RS16565 ENOG4105E0A ABC, transporter HVY52_RS16570 ENOG4108QY5 Ferric enterobactin transport protein HVY52_RS16575 ENOG4105C0W non-ribosomal peptide synthetase HVY52_RS16580 ENOG41085A6 mbth domain-containing protein HVY52_RS16585 ENOG4105E93 esterase HVY52_RS16590 ENOG4107RNH Outer membrane receptor FepA HVY52_RS16595 ENOG4108TSE Transferase HVY52_RS16615 ENOG4105WQ6 Membrane HVY52_RS16620 ENOG4105MSB protein, conserved in bacteria HVY52_RS16625 ENOG4108RCM Nitroreductase HVY52_RS16630 ENOG4105CUY Mechanosensitive ion channel HVY52_RS16635 ENOG4105C85 amino acid HVY52_RS16640 ENOG4108IJF Heavy metal efflux pump, CzcA HVY52_RS16645 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVY52_RS16650 ENOG410624V efflux system protein HVY52_RS16655 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVY52_RS16660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY52_RS16665 ENOG4105GR3 Histidine kinase HVY52_RS16700 ENOG4107QMP dna polymerase iii subunits gamma and tau HVY52_RS16710 ENOG4105WD1 Membrane HVY52_RS16715 ENOG4108URS primosomal replication protein n'' HVY52_RS16720 ENOG4106428 Protein of unknown function (DUF2496) HVY52_RS16725 ENOG4105EGS Mechanosensitive ion channel HVY52_RS16730 ENOG4107XI7 Tetr family transcriptional regulator HVY52_RS16735 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY52_RS16740 ENOG4105BZS acriflavin resistance protein HVY52_RS16745 ENOG4108UKR Biofilm formation regulator YbaJ HVY52_RS16755 ENOG4105GSJ Inner membrane protein ylaC HVY52_RS16760 ENOG41066DG (EAL) domain protein HVY52_RS16765 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVY52_RS16775 ENOG41080UX Methyltransferase HVY52_RS16780 ENOG4108MNP Glycoprotein polysaccharide metabolism HVY52_RS16785 ENOG4105C29 acyl-CoA thioesterase HVY52_RS16790 ENOG4105BZU Histidine kinase HVY52_RS16795 ENOG4108YZA Nitrogen regulatory protein pii HVY52_RS16800 ENOG4105BZ1 (ABC) transporter HVY52_RS16805 ENOG4105BZ1 (ABC) transporter HVY52_RS16810 ENOG4108XM1 transcriptional regulator AsnC family HVY52_RS16820 ENOG4108NFA extracellular solute-binding protein HVY52_RS16830 ENOG4108TGP Thioesterase superfamily protein HVY52_RS16835 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVY52_RS16840 ENOG4105EIN peptidylprolyl cis-trans isomerase HVY52_RS16845 ENOG4105K70 DNA-binding protein HVY52_RS16850 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVY52_RS16870 ENOG4105M85 Bola protein HVY52_RS16875 ENOG4105IEY (LipO)protein HVY52_RS16880 ENOG4105EYM Major Facilitator superfamily HVY52_RS16885 ENOG4105E2S oxidase) subunit II HVY52_RS16890 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVY52_RS16895 ENOG4105CCU oxidase (Subunit III) HVY52_RS16900 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVY52_RS16920 ENOG4107HP6 Transcriptional regulator HVY52_RS16925 ENOG4107V59 shikimate HVY52_RS16930 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVY52_RS16940 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVY52_RS16950 ENOG4105D2S major facilitator superfamily HVY52_RS16955 ENOG4107RDB Major Facilitator HVY52_RS16965 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVY52_RS16970 ENOG4107S0N DJ-1 family HVY52_RS16985 ENOG4105CTB Polyprenyl synthetase HVY52_RS16990 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVY52_RS16995 ENOG4105CPC Aldo Keto reductase HVY52_RS17000 ENOG4108ZAI phosphatidylglycerophosphatase a HVY52_RS17005 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVY52_RS17015 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVY52_RS17020 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVY52_RS17030 ENOG4108KIC (LipO)protein HVY52_RS17035 ENOG4105DRB nucleoside-specific channel-forming protein HVY52_RS17040 ENOG4105N1F Hnh endonuclease HVY52_RS17045 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY52_RS17050 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY52_RS17055 ENOG4105VIE preprotein translocase, subunit YajC HVY52_RS17075 ENOG4107R28 alpha amylase, catalytic region HVY52_RS17080 ENOG4105C85 amino acid HVY52_RS17085 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVY52_RS17090 ENOG4105BZU Histidine kinase HVY52_RS17100 ENOG4107RH8 nuclease SbcCD subunit D HVY52_RS17105 ENOG4105EYH Exonuclease HVY52_RS17110 ENOG4105DKQ ROK family HVY52_RS17125 ENOG4105HBA AroM protein HVY52_RS17130 ENOG4105SS3 HVY52_RS17145 ENOG4105II7 pyrroline-5-carboxylate reductase HVY52_RS17150 ENOG4105BZU Histidine kinase HVY52_RS17155 ENOG4105VIF phosphate starvation-inducible protein HVY52_RS17170 ENOG4105CPF Cell wall formation (By similarity) HVY52_RS17175 ENOG4105UNH Membrane HVY52_RS17180 ENOG4105FR5 inner membrane protein YaiY HVY52_RS17185 ENOG4107QS8 (LipO)protein HVY52_RS17190 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVY52_RS17195 ENOG4107R6D beta-lactam binding protein AmpH HVY52_RS17200 ENOG4108PNB DNA-binding transcriptional regulator HVY52_RS17205 ENOG4108NSE outer membrane autotransporter barrel HVY52_RS17210 ENOG4105D52 delta-aminolevulinic acid dehydratase HVY52_RS17215 ENOG4105E2B Taurine dioxygenase HVY52_RS17220 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVY52_RS17225 ENOG4108IY8 ABC, transporter HVY52_RS17230 ENOG4106FTQ Taurine ABC transporter, periplasmic HVY52_RS17235 ENOG4107W19 lmbE family HVY52_RS17245 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY52_RS17250 ENOG4105DXD 2-methylcitrate dehydratase HVY52_RS17255 ENOG4105BZN citrate synthase HVY52_RS17260 ENOG4105CR4 methylisocitrate lyase HVY52_RS17265 ENOG4108JU7 Transcriptional regulator HVY52_RS17270 ENOG4105TDT uncharacterized protein yahO HVY52_RS17275 ENOG4105E82 cytochrome subunit of dehydrogenase HVY52_RS17280 ENOG4105BZU Histidine kinase HVY52_RS17285 ENOG4105C6F GntR Family Transcriptional Regulator HVY52_RS17290 ENOG4105CPQ Dehydrogenase HVY52_RS17295 ENOG4108I5G Major Facilitator superfamily HVY52_RS17300 ENOG4105BZU Histidine kinase HVY52_RS17310 ENOG4105BZU Histidine kinase HVY52_RS17315 ENOG4108HF7 Gcn5-related n-acetyltransferase HVY52_RS17325 ENOG4107SET aldo keto reductase HVY52_RS17330 ENOG4105EQ2 LysR family Transcriptional regulator HVY52_RS17385 ENOG4105ZTC transcriptional activator, Ogr delta HVY52_RS17395 ENOG4105C4R Atp-dependent dna helicase HVY52_RS17405 ENOG4105DFP Integrase HVY52_RS17410 ENOG4107QJE Chromosome Partitioning Protein HVY52_RS17445 ENOG4105PTU response to oxidative stress HVY52_RS17450 ENOG4108US3 tail fiber assembly HVY52_RS17455 ENOG4105Y9F tail fiber protein HVY52_RS17460 ENOG4105Y0G tail protein HVY52_RS17465 ENOG4108T86 baseplate J family protein HVY52_RS17485 ENOG4108NKR DNA circulation protein HVY52_RS17505 ENOG4105TKZ Tail Sheath HVY52_RS17550 ENOG4105EFC phage portal protein HK97 family HVY52_RS17560 ENOG4105CAR Terminase, large subunit HVY52_RS17620 ENOG4105HGD Antitermination protein HVY52_RS17625 ENOG4108MXB Protein of unknown function (DUF968) HVY52_RS17635 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVY52_RS17665 ENOG4108S1U HVY52_RS17685 ENOG4108R7K Metal Dependent Phosphohydrolase HVY52_RS17690 ENOG41077V0 CPS-53 (KpLE1) prophage HVY52_RS17700 ENOG4108KU3 Integrase HVY52_RS17720 ENOG4105FCK Membrane HVY52_RS17740 ENOG4105CIN aminoacyl-histidine dipeptidase HVY52_RS17755 ENOG4108S2Y peptide Chain Release factor HVY52_RS17765 ENOG4108HYG acetyltransferase HVY52_RS17770 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HVY52_RS17790 ENOG4107QYX exodeoxyribonuclease v alpha HVY52_RS17795 ENOG4107QKA exodeoxyribonuclease V beta HVY52_RS17800 ENOG4107QXK peptidase HVY52_RS17805 ENOG4105DSY exodeoxyribonuclease V, gamma HVY52_RS17810 ENOG4105RVB Prepilin peptidase dependent protein c HVY52_RS17815 ENOG4105SEN Protein of unknown function (DUF2509) HVY52_RS17820 ENOG4105JCS prepilin peptidase dependent protein HVY52_RS17825 ENOG4105IPU prepilin peptidase dependent protein A HVY52_RS17840 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVY52_RS17855 ENOG4105EE5 Membrane protein terC HVY52_RS17860 ENOG4105SUV lipoprotein YgdR HVY52_RS17865 ENOG4105CPC Aldo Keto reductase HVY52_RS17890 ENOG41060NJ transcriptional regulator HVY52_RS17900 ENOG4105RQF LysR family Transcriptional regulator HVY52_RS17905 ENOG4105CHU acetyl-coa acetyltransferase HVY52_RS17910 ENOG4108MHD transport protein HVY52_RS17915 ENOG4105ISV protein with bipartite regulator domain HVY52_RS17920 ENOG4108TC1 Transcriptional regulator HVY52_RS17930 ENOG410802X bacteriophage n4 adsorption protein b HVY52_RS17935 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVY52_RS17940 ENOG4105QUW HVY52_RS17945 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVY52_RS17950 ENOG4105DZC cytosine deaminase HVY52_RS17970 ENOG4105TNG K13735 adhesin invasin HVY52_RS17990 ENOG4108K5P (LipO)protein HVY52_RS17995 ENOG4105MP9 class II Aldolase HVY52_RS18015 ENOG4105C5Q Transcriptional regulator HVY52_RS18020 ENOG4105H3G oxidoreductase HVY52_RS18025 ENOG4105KME endoribonuclease L-psp HVY52_RS18035 ENOG4105CWC Acetylornithine deacetylase HVY52_RS18040 ENOG4105CVK Glutamate decarboxylase HVY52_RS18045 ENOG4105CSV Glutaminase HVY52_RS18050 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVY52_RS18055 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVY52_RS18060 ENOG4105C7W Xanthine dehydrogenase HVY52_RS18065 ENOG4107XAN XdhC and CoxI family HVY52_RS18080 ENOG4105CRK lysyL-tRNA synthetase HVY52_RS18090 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVY52_RS18095 ENOG4105T95 Thiol disulfide interChange protein HVY52_RS18100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY52_RS18105 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVY52_RS18110 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVY52_RS18115 ENOG4105Y75 tpr repeat protein HVY52_RS18125 ENOG4108UT2 hemolysin iii HVY52_RS18130 ENOG4105N5Z UPF0267 protein HVY52_RS18135 ENOG4105CS2 ec 3.2.1.21 HVY52_RS18165 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY52_RS18170 ENOG4105D0A hydroxylase HVY52_RS18175 ENOG4107RAQ aminopeptidase HVY52_RS18195 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVY52_RS18205 ENOG4108JQ1 Dehydrogenase HVY52_RS18220 ENOG4105MPN Membrane HVY52_RS18225 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVY52_RS18230 ENOG4105D64 Mechanosensitive ion channel HVY52_RS18235 ENOG4105D2N Aldolase HVY52_RS18250 ENOG4107Z1W Fructose transport system kinase HVY52_RS18255 ENOG4108R4K DNA-binding, transcriptional regulator HVY52_RS18260 ENOG4108Q8A Fructose-1,6-bisphosphatase HVY52_RS18265 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY52_RS18270 ENOG4105CTS PTS system mannitol-specific HVY52_RS18275 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVY52_RS18285 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY52_RS18290 ENOG4108K0D peptidase, M48 HVY52_RS18320 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVY52_RS18345 ENOG4107QNK )-transporter HVY52_RS18355 ENOG4105RWS endonuclease I HVY52_RS18360 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVY52_RS18365 ENOG4105D7Z glutathione synthase HVY52_RS18380 ENOG4105CZX twitching motility protein HVY52_RS18385 ENOG4105DFA alanine racemase domain protein HVY52_RS18390 ENOG4108VIA integral membrane protein HVY52_RS18400 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVY52_RS18405 ENOG4105CSA Coproporphyrinogen iii oxidase HVY52_RS18410 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY52_RS18415 ENOG41069H7 transport system small permease component HVY52_RS18420 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY52_RS18425 ENOG4106MH3 alpha helix chain HVY52_RS18430 ENOG4105HDK L-asparaginase HVY52_RS18435 ENOG4105K33 Periplasmic Protein HVY52_RS18440 ENOG41090ED Protein with unknown function (DUF469) HVY52_RS18450 ENOG4105CEN a g-specific adenine glycosylase HVY52_RS18465 ENOG4105EAA nucleoside HVY52_RS18470 ENOG4105CXN decarboxylase HVY52_RS18475 ENOG4108UQV Membrane HVY52_RS18500 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVY52_RS18510 ENOG4108XKW General secretion pathway protein C HVY52_RS18520 ENOG4107QHF type ii secretion system protein e HVY52_RS18525 ENOG4105D7Q type ii secretion system HVY52_RS18530 ENOG4108VAU general secretion pathway protein G HVY52_RS18540 ENOG4105X5Z General secretion pathway protein I HVY52_RS18560 ENOG4105U1E general secretion pathway protein M HVY52_RS18565 ENOG410600K aminopeptidase HVY52_RS18570 ENOG410600T transposase HVY52_RS18580 ENOG4106032 Glutathionylspermidine synthase HVY52_RS18590 ENOG4105CYM Glutathione S-transferase HVY52_RS18595 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVY52_RS18605 ENOG4108WGS hydrogenase 2-specific chaperone HVY52_RS18610 ENOG4108USZ hydrogenase HVY52_RS18615 ENOG4105DPX Hydrogenase, large subunit HVY52_RS18620 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVY52_RS18625 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY52_RS18630 ENOG4105E3S small subunit HVY52_RS18635 ENOG410900S Protein of unknown function (DUF2623) HVY52_RS18645 ENOG4105CPC Aldo Keto reductase HVY52_RS18655 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVY52_RS18660 ENOG4108ZZF transport protein (ExbD) HVY52_RS18665 ENOG4105CWK Biopolymer transport protein, ExbB HVY52_RS18670 ENOG4105C28 cystathionine HVY52_RS18675 ENOG4108K81 inner membrane protein YghB HVY52_RS18680 ENOG4105CF7 AraC family transcriptional regulator HVY52_RS18685 ENOG4108I6A alcohol dehydrogenase HVY52_RS18690 ENOG4105CV8 reductase HVY52_RS18695 ENOG4107QPK )-transporter HVY52_RS18705 ENOG4105CCT upf0313 protein HVY52_RS18710 ENOG4107YCY Transcriptional regulator HVY52_RS18715 ENOG4105DEI Mannitol dehydrogenase HVY52_RS18720 ENOG4105CPQ Dehydrogenase HVY52_RS18725 ENOG4105DG4 malate L-lactate dehydrogenase HVY52_RS18730 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY52_RS18740 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY52_RS18745 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVY52_RS18750 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVY52_RS18755 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY52_RS18760 ENOG4105H4F exported protein HVY52_RS18765 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY52_RS18770 ENOG4105DHQ Histidine kinase HVY52_RS18775 ENOG4105NF4 modulator of drug activity HVY52_RS18780 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVY52_RS18785 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY52_RS18790 ENOG4105IPS esterase HVY52_RS18795 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVY52_RS18800 ENOG4108SX3 cytoplasmic protein HVY52_RS18805 ENOG41087AY ADP-Ribose pyrophosphatase HVY52_RS18810 ENOG4105DFG type I secretion outer membrane protein HVY52_RS18820 ENOG4106032 Glutathionylspermidine synthase HVY52_RS18825 ENOG4108MR7 Arylsulfotransferase HVY52_RS18830 ENOG4108N92 Thiol disulfide Interchange Protein HVY52_RS18840 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVY52_RS18855 ENOG4105H8W Fimbrial protein HVY52_RS18865 ENOG4108TTM chaperone HVY52_RS18870 ENOG4108MY7 Fimbrial HVY52_RS18880 ENOG4105W0Z cytoplasmic protein HVY52_RS18890 ENOG4105PV3 Inner membrane protein yqiJ HVY52_RS18895 ENOG4107S78 Band 7 protein HVY52_RS18925 ENOG4105I7R Adenylate cyclase HVY52_RS18930 ENOG4106MWK domain protein HVY52_RS18945 ENOG4107ZVW dihydroneopterin aldolase HVY52_RS18955 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVY52_RS18965 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVY52_RS18970 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY52_RS18990 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVY52_RS19030 ENOG41080XV Thioredoxin HVY52_RS19040 ENOG4105Q26 Siderophore-interacting protein HVY52_RS19045 ENOG4105NTW Transcriptional regulator HVY52_RS19050 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVY52_RS19060 ENOG4105CBP Major Facilitator HVY52_RS19070 ENOG4105C6F GntR Family Transcriptional Regulator HVY52_RS19075 ENOG4105DEI Mannitol dehydrogenase HVY52_RS19085 ENOG4105Y4Z Outer Membrane Lipoprotein HVY52_RS19095 ENOG4105KT7 mgtC SapB transporter HVY52_RS19100 ENOG4105XXV Acid-resistance protein HVY52_RS19105 ENOG41060V2 Acid-resistance protein HVY52_RS19110 ENOG4108YK4 Acid-resistance membrane protein HVY52_RS19115 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVY52_RS19120 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY52_RS19125 ENOG4105BZS acriflavin resistance protein HVY52_RS19135 ENOG4108NKV transcriptional regulator HVY52_RS19140 ENOG4105D6F Phosphatase HVY52_RS19145 ENOG4108V8F Transcriptional regulator, MarR family HVY52_RS19170 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HVY52_RS19175 ENOG4105FUY alpha subunit HVY52_RS19180 ENOG4107Z7P Ferredoxin HVY52_RS19185 ENOG4105CSP Major Facilitator Superfamily HVY52_RS19190 ENOG4106D80 Uncharacterized protein YhaL HVY52_RS19205 ENOG4105C7B Threonine dehydratase HVY52_RS19210 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVY52_RS19215 ENOG4105CIZ coA-substrate-specific enzyme activase HVY52_RS19225 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY52_RS19230 ENOG4105C8Q Methyl-accepting chemotaxis HVY52_RS19240 ENOG4108IA2 Sodium pantothenate symporter HVY52_RS19260 ENOG4108V8F Transcriptional regulator, MarR family HVY52_RS19265 ENOG4105ERH Fumarylacetoacetate hydrolase HVY52_RS19270 ENOG4105C26 Dehydrogenase HVY52_RS19275 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVY52_RS19305 ENOG4105EFA 4-hydroxyphenylacetate HVY52_RS19310 ENOG4107UWN reductase HVY52_RS19315 ENOG4105D22 carbon starvation protein HVY52_RS19320 ENOG4105VCD cytoplasmic protein HVY52_RS19325 ENOG4105CKI cobalamin synthesis protein HVY52_RS19345 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HVY52_RS19350 ENOG4105CVR type I restriction-modification system HVY52_RS19365 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HVY52_RS19370 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC HVY52_RS19380 ENOG4108YUH HVY52_RS19385 ENOG4106DIZ Domain of unknown function (DUF1127) HVY52_RS19390 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY52_RS19400 ENOG41083G8 Multidrug resistance protein MdtM HVY52_RS19405 ENOG4106BRA Membrane HVY52_RS19415 ENOG4108YXQ IS66 Orf2 family protein HVY52_RS19425 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVY52_RS19460 ENOG4105C9U ATP-dependent DNA helicase RecQ HVY52_RS19465 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVY52_RS19470 ENOG4108RS6 transposase HVY52_RS19500 ENOG4105DQ4 alcohol dehydrogenase HVY52_RS19505 ENOG4105D7A ATP-binding protein HVY52_RS19510 ENOG4107S21 permease HVY52_RS19515 ENOG4105K4T epimerase HVY52_RS19520 ENOG4107R7Y intracellular protease Pfpi family HVY52_RS19535 ENOG4108YYD acetyltransferase HVY52_RS19555 ENOG4105DEN Luciferase family HVY52_RS19560 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVY52_RS19605 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HVY52_RS19625 ENOG4108K70 Transcriptional regulator HVY52_RS19630 ENOG4105CIC tryptophan-specific transport protein HVY52_RS19635 ENOG4105C1J atp-dependent rna helicase HVY52_RS19675 ENOG4105CHV Transcription elongation factor NusA HVY52_RS19695 ENOG4105DIJ Phosphoethanolamine transferase HVY52_RS19705 ENOG4105NTZ Preprotein translocase subunit SecG HVY52_RS19715 ENOG4105EEI dihydropteroate synthase HVY52_RS19720 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVY52_RS19730 ENOG4105HBR Rna-binding protein HVY52_RS19735 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVY52_RS19740 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVY52_RS19750 ENOG4105QYV Membrane HVY52_RS19765 ENOG4105EAH synthase HVY52_RS19770 ENOG4105HVQ Regulatory factor of maltose metabolism HVY52_RS19780 ENOG4105VFK BolA family HVY52_RS19785 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVY52_RS19790 ENOG4105E3I toluene tolerance HVY52_RS19795 ENOG4107PE3 Mammalian cell entry related domain protein HVY52_RS19800 ENOG4105CY3 ABC transporter, permease HVY52_RS19805 ENOG4105DHJ ABC, transporter HVY52_RS19810 ENOG4105FEU K -dependent Na -Ca exchanger HVY52_RS19815 ENOG4105C2X Arabinose 5-phosphate isomerase HVY52_RS19825 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVY52_RS19830 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVY52_RS19835 ENOG4108IUZ ABC transporter HVY52_RS19840 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY52_RS19845 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVY52_RS19850 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVY52_RS19860 ENOG41080Z8 PHOSPHOCARRIER protein HVY52_RS19865 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVY52_RS19875 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVY52_RS19880 ENOG4105BZU Histidine kinase HVY52_RS19885 ENOG4105N5T Radical SAM Protein HVY52_RS19890 ENOG4105CBC glutamate synthase HVY52_RS19895 ENOG4105BZ8 glutamate synthase HVY52_RS19900 ENOG4105DFS Conserved Protein HVY52_RS19905 ENOG4108R66 Conserved Protein HVY52_RS19935 ENOG4105KB2 stringent starvation protein b HVY52_RS19940 ENOG4107MKT Stringent starvation protein a HVY52_RS19955 ENOG4105D6Z AFG1 family ATPase HVY52_RS19960 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVY52_RS19965 ENOG4105C0H protease HVY52_RS19970 ENOG4105C0H protease HVY52_RS19980 ENOG4107GFK fumarate HVY52_RS19985 ENOG4106DSS Tartrate dehydratase subunit alpha HVY52_RS19990 ENOG4105C8P )-transporter HVY52_RS20000 ENOG4105G3Z GntR family transcriptional regulator HVY52_RS20015 ENOG4105RID UPF0379 protein yhcN HVY52_RS20020 ENOG4105UNR (Barnase) inhibitor HVY52_RS20035 ENOG4105ZQC membrane protein AaeX HVY52_RS20040 ENOG4105CR8 Transcriptional regulator HVY52_RS20045 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVY52_RS20050 ENOG4105QD6 exported protein HVY52_RS20055 ENOG4105C03 ribonuclease HVY52_RS20065 ENOG4105VQ7 Rod shape-determining protein MreD HVY52_RS20070 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVY52_RS20080 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVY52_RS20085 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVY52_RS20100 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVY52_RS20105 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVY52_RS20110 ENOG4105RG0 Membrane HVY52_RS20115 ENOG4108IA2 Sodium pantothenate symporter HVY52_RS20125 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY52_RS20135 ENOG4105CEC DNA methylase N-4 N-6 HVY52_RS20140 ENOG41061ME transport protein HVY52_RS20145 ENOG4108XG4 DNA-binding transcriptional regulator HVY52_RS20150 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY52_RS20155 ENOG4105BZS acriflavin resistance protein HVY52_RS20160 ENOG4105XCM membrane LIPOPROTEIN HVY52_RS20170 ENOG4105EZ7 amino acid ABC transporter HVY52_RS20175 ENOG4105DRP amino acid AbC transporter HVY52_RS20180 ENOG4105CDA abc transporter atp-binding protein HVY52_RS20220 ENOG4108Z0R Transferase HVY52_RS20225 ENOG4105SG3 Protein of unknown function (DUF1488) HVY52_RS20240 ENOG4108WI1 Dna topoisomerase HVY52_RS20250 ENOG4105C79 DNA protecting protein DprA HVY52_RS20270 ENOG4105C1A potassium transporter peripheral membrane HVY52_RS20280 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVY52_RS20285 ENOG4105W1Y Transcriptional regulator HVY52_RS20290 ENOG4105VTS DnaJ-like, subfamily C HVY52_RS20320 ENOG41067V7 50S ribosomal protein L36 HVY52_RS20325 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVY52_RS20370 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVY52_RS20415 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVY52_RS20440 ENOG4108UQY Iron-storage protein HVY52_RS20445 ENOG4105W53 bacterioferritin-associated ferredoxin HVY52_RS20485 ENOG4105WWK YheO domain protein HVY52_RS20490 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY52_RS20500 ENOG4108YZY peptidylprolyl cis-trans isomerase HVY52_RS20505 ENOG4105VKU nucleicacid-binding protein HVY52_RS20520 ENOG4105C5H ABC transporter HVY52_RS20525 ENOG4105DNZ Alpha Beta Hydrolase HVY52_RS20535 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVY52_RS20540 ENOG4108UKZ OsmC family HVY52_RS20550 ENOG410613R integral membrane protein, YccS YhfK family HVY52_RS20555 ENOG4105C8Y Acetylornithine aminotransferase HVY52_RS20560 ENOG4105DDQ anthranilate synthase HVY52_RS20565 ENOG4105MZU cell filamentation protein HVY52_RS20575 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY52_RS20580 ENOG4107QZF nitrite reductase NADPH large subunit HVY52_RS20585 ENOG4105WZK nitrite reductase NADPH small subunit HVY52_RS20590 ENOG4107V9H nitrite transporter HVY52_RS20600 ENOG4105VYH HVY52_RS20605 ENOG4106PKC pyridoxal phosphate binding HVY52_RS20610 ENOG4106M0N transport system permease protein HVY52_RS20615 ENOG4105MUZ Protein of unknown function DUF2620 HVY52_RS20620 ENOG41080QX K07048 phosphotriesterase-related protein HVY52_RS20625 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVY52_RS20630 ENOG4108626 Racemase HVY52_RS20635 ENOG4105RMW regulation of transcription, DNA-dependent HVY52_RS20640 ENOG4108M21 HVY52_RS20645 ENOG4105C31 Tryptophanyl-tRNA synthetase HVY52_RS20650 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVY52_RS20655 ENOG4105DJV ribulose-phosphate 3-epimerase HVY52_RS20660 ENOG4105DFE Dna adenine methylase HVY52_RS20665 ENOG4105EGB membrane protein DamX HVY52_RS20680 ENOG4105E4G Type IV pilus HVY52_RS20685 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVY52_RS20690 ENOG4105XPX DNA utilization protein HofO HVY52_RS20695 ENOG41065NF Fimbrial assembly family protein HVY52_RS20700 ENOG4108U1Q Pilus assembly protein HVY52_RS20705 ENOG4108JQC penicillin-binding protein 1A HVY52_RS20710 ENOG4107RK2 ADP-ribose diphosphatase NudE HVY52_RS20715 ENOG4105DQY intracellular growth attenuator HVY52_RS20720 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVY52_RS20725 ENOG4105VEJ Heat shock protein HVY52_RS20735 ENOG4108MAJ Membrane HVY52_RS20755 ENOG4105E0F Histidine kinase HVY52_RS20765 ENOG4108RRZ Transcription elongation factor GreB HVY52_RS20770 ENOG4105BZM domain protein HVY52_RS20775 ENOG4105XFK Ferrous iron transport protein A HVY52_RS20780 ENOG4105CE1 Ferrous iron transport protein b HVY52_RS20790 ENOG4105DNE Transposase HVY52_RS20800 ENOG4105MJ2 Competence protein HVY52_RS20810 ENOG4105C6Z Gluconate HVY52_RS20820 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVY52_RS20825 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY52_RS20840 ENOG4105E0Y RtcB Protein HVY52_RS20845 ENOG4105CYB regulatoR HVY52_RS20850 ENOG4105E98 transcriptional regulator DeoR family HVY52_RS20865 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVY52_RS20880 ENOG4105CVA phosphate HVY52_RS20885 ENOG4105MHR Fimbrial protein HVY52_RS20890 ENOG4106PH7 chaperone HVY52_RS20900 ENOG4108WDE Fimbrial protein HVY52_RS20905 ENOG4105CW0 outer membrane usher protein HVY52_RS20910 ENOG4108NAE Fimbrial chaperone protein HVY52_RS20920 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY52_RS20945 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY52_RS20950 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVY52_RS20955 ENOG4105C6Z Gluconate HVY52_RS20960 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVY52_RS20965 ENOG4105DIQ Transcriptional regulator HVY52_RS20970 ENOG4105C2I pirin domain protein HVY52_RS20975 ENOG4105D9R oxidoreductase HVY52_RS20980 ENOG4105WCN acetyltransferase HVY52_RS20985 ENOG4105GMB type VI secretion system effector, hcp1 family HVY52_RS20990 ENOG4106FA4 HVY52_RS20995 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVY52_RS21000 ENOG4105WC8 Conserved Protein HVY52_RS21005 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVY52_RS21015 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVY52_RS21020 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVY52_RS21025 ENOG4105BZ7 extracellular solute-binding protein family 1 HVY52_RS21030 ENOG4108IV0 ABC, transporter HVY52_RS21035 ENOG4105C0Z ABC transporter HVY52_RS21040 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVY52_RS21045 ENOG4105C32 Amino acid ABC transporter (Permease) HVY52_RS21050 ENOG4105CP9 extracellular ligand-binding receptor HVY52_RS21055 ENOG4105U59 -acetyltransferase HVY52_RS21060 ENOG4105CP9 extracellular ligand-binding receptor HVY52_RS21065 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY52_RS21070 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVY52_RS21075 ENOG4105CAK Cell division ATP-binding protein ftsE HVY52_RS21080 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVY52_RS21085 ENOG4106H78 methyltransferase HVY52_RS21090 ENOG4105MG3 Membrane HVY52_RS21100 ENOG4107FS9 Membrane HVY52_RS21115 ENOG4105EX9 Membrane HVY52_RS21120 ENOG4108W1V Lipoprotein HVY52_RS21125 ENOG4105F9N Major Facilitator Superfamily HVY52_RS21130 ENOG4105DSF transport protein HVY52_RS21150 ENOG4105E9Q Acyl-transferase HVY52_RS21180 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HVY52_RS21205 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY52_RS21215 ENOG4105C2D reductase HVY52_RS21220 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY52_RS21225 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVY52_RS21235 ENOG4105CMI transporter HVY52_RS21240 ENOG4105CJ1 ABC, transporter HVY52_RS21245 ENOG4105D0S secretion protein (HlyD HVY52_RS21250 ENOG4107UNS conserved inner membrane protein HVY52_RS21275 ENOG4105CBX hi0933 family HVY52_RS21280 ENOG4105CJ3 phosphate transporter HVY52_RS21295 ENOG4105DUX Transporter HVY52_RS21305 ENOG4105DGW oligopeptidase A HVY52_RS21310 ENOG4105D6S protein involved in catabolism of external DNA HVY52_RS21315 ENOG4105DC8 reductase HVY52_RS21325 ENOG4105KBH arsR family transcriptional regulator HVY52_RS21330 ENOG4107R5R arsenical pump membrane protein HVY52_RS21335 ENOG4105K89 arsenate reductase HVY52_RS21355 ENOG4106S2D Transcriptional regulator HVY52_RS21360 ENOG4107H3J ribonuclease HVY52_RS21365 ENOG4105CSH Transporter HVY52_RS21370 ENOG41066T0 asmA family HVY52_RS21375 ENOG4105CMB EAL domain-containing protein HVY52_RS21380 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVY52_RS21395 ENOG4105CS0 peptidase HVY52_RS21405 ENOG4105BZU Histidine kinase HVY52_RS21410 ENOG4105EJG cellulose synthase HVY52_RS21415 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVY52_RS21420 ENOG4107EEX Cellulose synthase regulator protein HVY52_RS21425 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY52_RS21435 ENOG410661M cytoplasmic protein HVY52_RS21440 ENOG4105U74 cellulose biosynthesis protein BcsE HVY52_RS21445 ENOG4105WQA Cellulose biosynthesis protein BcsF HVY52_RS21450 ENOG4105D1V cellulose synthase operon protein YhjU HVY52_RS21470 ENOG4105C28 cystathionine HVY52_RS21475 ENOG4105C44 Serine transporter HVY52_RS21485 ENOG4108JQ7 (ABC) transporter HVY52_RS21490 ENOG4105C3U ABC transporter HVY52_RS21495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY52_RS21500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY52_RS21505 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY52_RS21520 ENOG4105DIJ Phosphoethanolamine transferase HVY52_RS21525 ENOG4105FCD Major Facilitator HVY52_RS21530 ENOG4105EAX Putative lipase HVY52_RS21535 ENOG4108R3E Dna-3-methyladenine glycosylase i HVY52_RS21540 ENOG4105HNP -acetyltransferase HVY52_RS21545 ENOG4107QY8 reductase HVY52_RS21550 ENOG4108ZG0 Ompa motb domain protein HVY52_RS21555 ENOG4108M60 Transcriptional regulator HVY52_RS21565 ENOG4105D7K pfkb domain protein HVY52_RS21580 ENOG4106JH6 (LipO)protein HVY52_RS21585 ENOG4105D2S major facilitator superfamily HVY52_RS21590 ENOG4105MVF Transcriptional regulator HVY52_RS21605 ENOG41060TC Hok gef cell toxic protein HVY52_RS21630 ENOG4105MEV Acyl-transferase HVY52_RS21635 ENOG410688U Inner membrane protein yiaB HVY52_RS21640 ENOG4105CMG Carbohydrate kinase HVY52_RS21650 ENOG4105T16 Transcriptional regulator (AraC family) HVY52_RS21655 ENOG4108UR8 BAX protein HVY52_RS21660 ENOG4107T9C Alpha amylase catalytic region HVY52_RS21665 ENOG4105JKW Valine--pyruvate aminotransferase HVY52_RS21670 ENOG4108XIB electron transport protein ysaA HVY52_RS21675 ENOG4105J4Q Transcriptional regulator HVY52_RS21685 ENOG4108R66 Conserved Protein HVY52_RS21690 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVY52_RS21695 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY52_RS21700 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY52_RS21705 ENOG4105CMG Carbohydrate kinase HVY52_RS21710 ENOG4105H6Q decarboxylase HVY52_RS21715 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVY52_RS21720 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY52_RS21725 ENOG4105C26 Dehydrogenase HVY52_RS21730 ENOG4105C0A alcohol dehydrogenase HVY52_RS21735 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVY52_RS21745 ENOG4108U78 Glutathione S-transferase HVY52_RS21750 ENOG4105EFX secretion protein, HlyD family HVY52_RS21755 ENOG4105FP6 Protein of unknown function (DUF3302) HVY52_RS21760 ENOG4105CTS PTS system mannitol-specific HVY52_RS21770 ENOG4105E61 Mannitol repressor protein HVY52_RS21780 ENOG4108YYI Protein of unknown function (DUF2810) HVY52_RS21785 ENOG4108WY4 inner membrane lipoprotein HVY52_RS21790 ENOG4105EUR Domain-Containing protein HVY52_RS21795 ENOG4105DAA L-lactate HVY52_RS21800 ENOG41073TP transcriptional regulator HVY52_RS21810 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVY52_RS21815 ENOG4105D7W serine acetyltransferase HVY52_RS21830 ENOG4105VW4 glutaredoxin 3 HVY52_RS21835 ENOG4107YZP Rhodanese domain protein HVY52_RS21845 ENOG41063SB peptidase HVY52_RS21850 ENOG4105PXI polysaccharide deacetylase HVY52_RS21855 ENOG4105K64 Glycosyl transferase, family 2 HVY52_RS21860 ENOG4105D4P Coproporphyrinogen iii oxidase HVY52_RS21865 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVY52_RS21880 ENOG4105C2M dna polymerase I HVY52_RS21885 ENOG4106HNH Acyl-transferase HVY52_RS21895 ENOG4108Z33 Thiol disulfide Interchange Protein HVY52_RS21900 ENOG4105E27 serine threonine protein kinase HVY52_RS21905 ENOG4105PC1 Conserved Protein HVY52_RS21910 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVY52_RS21915 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVY52_RS21945 ENOG4108RR8 protoporphyrinogen oxidase HVY52_RS21950 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY52_RS21955 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVY52_RS21975 ENOG4108MR7 Arylsulfotransferase HVY52_RS21980 ENOG4108EX3 reductase HVY52_RS21985 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY52_RS21990 ENOG4105MDZ Transcriptional activator rfaH HVY52_RS22000 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVY52_RS22005 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVY52_RS22010 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVY52_RS22020 ENOG4105JC1 sterol-binding domain protein HVY52_RS22030 ENOG4105CGY Dna recombination protein HVY52_RS22035 ENOG4107HP6 Transcriptional regulator HVY52_RS22040 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVY52_RS22045 ENOG4108RTU Aldolase HVY52_RS22050 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVY52_RS22065 ENOG4108I5U Uridine phosphorylase HVY52_RS22070 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVY52_RS22095 ENOG4105F04 LysR family Transcriptional regulator HVY52_RS22110 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HVY52_RS22115 ENOG4105C7F AcnD-accessory protein PrpF HVY52_RS22120 ENOG4107QM5 aconitate hydratase HVY52_RS22125 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVY52_RS22130 ENOG4107QIJ Aconitate hydratase 2 HVY52_RS22145 ENOG4105DZ2 Transcriptional regulator HVY52_RS22150 ENOG4105EMK carboxylate amino acid amine transporter HVY52_RS22155 ENOG4105DQF Hydrolase HVY52_RS22160 ENOG4108EUD Lysophospholipase HVY52_RS22165 ENOG410829K Lysine exporter protein (Lyse ygga) HVY52_RS22175 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVY52_RS22180 ENOG4105C9U ATP-dependent DNA helicase RecQ HVY52_RS22190 ENOG4105HDD phospholipase HVY52_RS22195 ENOG4108VUY thioesterase Superfamily protein HVY52_RS22200 ENOG4105FR1 rard protein HVY52_RS22205 ENOG4106WR8 Inner membrane protein YigG HVY52_RS22210 ENOG4105NRM Membrane HVY52_RS22215 ENOG4107QUT magnesium and cobalt transport protein CorA HVY52_RS22220 ENOG4108T58 Mg2 transport protein CorA HVY52_RS22225 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVY52_RS22230 ENOG4105C4R Atp-dependent dna helicase HVY52_RS22235 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVY52_RS22245 ENOG4105CT0 Protein of unknown function, DUF484 HVY52_RS22255 ENOG4105S7Z (LipO)protein HVY52_RS22275 ENOG4107T0K Adenylate cyclase HVY52_RS22285 ENOG41076E6 Uroporphyrinogen-III Synthase HVY52_RS22290 ENOG4105ECF c-methyltransferase HVY52_RS22295 ENOG410601J HemY protein HVY52_RS22305 ENOG4105ENH Sulfatase HVY52_RS22310 ENOG4105C4X radical SAM domain protein HVY52_RS22335 ENOG4105C85 amino acid HVY52_RS22350 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HVY52_RS22355 ENOG4105EGZ biosynthesis protein HVY52_RS22360 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVY52_RS22365 ENOG4108WJ1 acetyltransferase HVY52_RS22370 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY52_RS22375 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY52_RS22380 ENOG4107QQG Dehydrogenase HVY52_RS22385 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVY52_RS22390 ENOG4105SFE lipopolysaccharide biosynthesis protein HVY52_RS22395 ENOG4105ESV Glycosyl transferase, family 4 HVY52_RS22400 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVY52_RS22425 ENOG4105C4R Atp-dependent dna helicase HVY52_RS22430 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVY52_RS22440 ENOG4105EMY transcriptional regulator HVY52_RS22445 ENOG4105C7B Threonine dehydratase HVY52_RS22455 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVY52_RS22460 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVY52_RS22480 ENOG4105C0P Mg chelatase subunit ChlI HVY52_RS22485 ENOG4108WFC UPF0438 protein yifE HVY52_RS22525 ENOG4107EJG GntR family transcriptional regulator HVY52_RS22530 ENOG4105ETE Transcriptional regulator (LacI family HVY52_RS22535 ENOG4108RVA ribokinase HVY52_RS22540 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY52_RS22545 ENOG4105CNN ABC, transporter HVY52_RS22550 ENOG4105C2J ABC transporter HVY52_RS22580 ENOG4108VVK transcriptional Regulator, AsnC HVY52_RS22585 ENOG4105QTB Flavodoxin HVY52_RS22600 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVY52_RS22655 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVY52_RS22660 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVY52_RS22665 ENOG4105C8U phosphate abc transporter HVY52_RS22670 ENOG4105E2Z phosphate ABC transporter (Permease HVY52_RS22675 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVY52_RS22680 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVY52_RS22685 ENOG4105CID antiterminator HVY52_RS22690 ENOG4105C5Y PTS System HVY52_RS22695 ENOG4105CS2 ec 3.2.1.21 HVY52_RS22705 ENOG4105DYC esterase HVY52_RS22710 ENOG4107VKM 6-phosphogluconolactonase HVY52_RS22715 ENOG4106611 bacteriocin immunity HVY52_RS22725 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVY52_RS22730 ENOG4105C7N Xanthine uracil vitamin C permease HVY52_RS22740 ENOG4108YYH Nadph-dependent fmn reductase HVY52_RS22745 ENOG4105E8Q phosphopantetheinyl transferase HVY52_RS22760 ENOG4108P6C Tryptophan transporter of low affinity HVY52_RS22795 ENOG4105VG0 50S ribosomal protein l34 HVY52_RS22805 ENOG4106JVB Replication Protein HVY52_RS22945 ENOG4105C4R Atp-dependent dna helicase HVY52_RS23090 ENOG4108M24 von Willebrand factor, type A HVY52_RS23095 ENOG4108M24 von Willebrand factor, type A HVY52_RS23125 ENOG4105DAX Pfam:DUF2983 HVY52_RS23205 ENOG4105CAF HipA N-terminal domain protein HVY52_RS23225 ENOG4108R0M Aminoglycoside HVY52_RS23240 ENOG4105D6U Sodium Glutamate Symporter HVY52_RS23255 ENOG4108ZHR arsR family transcriptional regulator HVY52_RS23305 ENOG4108BUD transposase HVY52_RS23325 ENOG4108BUD transposase HVY52_RS23350 ENOG4108BUD transposase HVY52_RS23365 ENOG4108BUD transposase HVY52_RS23380 ENOG4105EMU Dehydrogenase HVY52_RS23385 ENOG4108BUD transposase HVY52_RS23430 ENOG4108BUD transposase HVY52_RS23500 ENOG410624V efflux system protein HVY52_RS23530 ENOG4105DR5 peptidase HVY52_RS23540 ENOG4105E3B Multicopper oxidase HVY52_RS23545 ENOG4105VR0 copper resistance HVY52_RS23550 ENOG4105JDN Copper resistance protein HVY52_RS23555 ENOG4108PG2 copper resistance HVY52_RS23560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY52_RS23565 ENOG4105GR3 Histidine kinase HVY52_RS23650 ENOG4108KTG Membrane protein, drug metabolite transporter HVY52_RS23730 ENOG4108BUD transposase HVY52_RS23760 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HVY52_RS23780 ENOG4105T95 Thiol disulfide interChange protein HVY52_RS23940 ENOG4108SER Transposase HVY52_RS23945 ENOG41074AV Hok/gef family HVY52_RS24110 ENOG4108BUD transposase HVY52_RS24135 ENOG410607W Transposase HVY52_RS24145 ENOG4105K4U addiction module toxin, RelE StbE family HVY52_RS24155 ENOG4108BUD transposase HVY52_RS24170 ENOG4108BUD transposase HVY52_RS24180 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVY52_RS24200 ENOG4106JVB Replication Protein HVY52_RS24205 ENOG410607W Transposase HVY52_RS24250 ENOG4105DFE Dna adenine methylase HVY52_RS24345 ENOG4108ZMA Outer membrane lipoprotein HVY52_RS24350 ENOG41066DY Membrane HVY52_RS24395 ENOG4108X9F tail fiber protein HVY52_RS24405 ENOG4105UZW Tail fiber assembly protein HVY52_RS24410 ENOG410685N tail fiber protein HVY52_RS24415 ENOG4108C33 Resolvase HVY52_RS24470 ENOG4108UUM single-stranded DNA-binding protein HVY52_RS24580 ENOG4105KT5 UmuD protein HVY52_RS24595 ENOG4105MPK DNA polymerase III subunit theta HVY52_RS24685 ENOG4108R1E Serine threonine protein phosphatase 1 HVY52_RS24745 ENOG4105CDU Replicative dna helicase HVY52_RS24775 ENOG4105DFE Dna adenine methylase HVY52_RS24780 ENOG4105DH7 May be involved in recombination (By similarity) HVY52_RS24820 ENOG4105UZW Tail fiber assembly protein HVY52_RS24825 ENOG4108X9F tail fiber protein HVY52_RS24900 ENOG4105IM0 capsid protein HVY52_RS24910 ENOG4105F7J membrane-bound serine protease HVY52_RS24920 ENOG4107DE1 head-to-tail joining protein HVY52_RS24925 ENOG4105UZW Tail fiber assembly protein HVY52_RS24930 ENOG4105FKG DNA packaging protein HVY52_RS24950 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVY52_RS24955 ENOG4105KUS lysozyme