locus-tag class description HVY57_RS00020 ENOG4105ED4 portal protein HVY57_RS00110 ENOG410685N tail fiber protein HVY57_RS00115 ENOG4105UZW Tail fiber assembly protein HVY57_RS00165 ENOG4105ZTC transcriptional activator, Ogr delta HVY57_RS00170 ENOG4105C6N Formate acetyltransferase HVY57_RS00175 ENOG4105TMB Formate nitrite transporter HVY57_RS00180 ENOG4105DDY UPF0142 protein ycaO HVY57_RS00185 ENOG4107VMU Membrane HVY57_RS00205 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVY57_RS00230 ENOG4105BZ1 (ABC) transporter HVY57_RS00240 ENOG4105T0Z Conserved Protein HVY57_RS00255 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVY57_RS00260 ENOG4107S90 membrAne HVY57_RS00265 ENOG4106371 Methyltransferase HVY57_RS00275 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVY57_RS00285 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVY57_RS00290 ENOG4105EAQ (twin-arginine translocation) pathway signal HVY57_RS00295 ENOG4105C5X domain protein HVY57_RS00300 ENOG4105CGF Aromatic amino acid aminotransferase HVY57_RS00320 ENOG4105CD8 aminopeptidase N HVY57_RS00325 ENOG4105E2Y ABC, transporter HVY57_RS00330 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVY57_RS00340 ENOG4105GVF (ABC) transporter HVY57_RS00345 ENOG4108UZX fmn reductase HVY57_RS00355 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVY57_RS00360 ENOG4105QVC MOSC domain-containing protein HVY57_RS00370 ENOG4105C5H ABC transporter HVY57_RS00375 ENOG4105F1S paraquat-inducible protein a HVY57_RS00380 ENOG4105DY2 Paraquat-inducible protein b HVY57_RS00385 ENOG4108Q2G (LipO)protein HVY57_RS00390 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVY57_RS00400 ENOG4105DAN ATP-dependent protease HVY57_RS00420 ENOG4108RZ1 DNA transformation protein HVY57_RS00425 ENOG4105EM2 membrane HVY57_RS00430 ENOG410901E Membrane HVY57_RS00435 ENOG41088T4 Helicase IV HVY57_RS00450 ENOG4105K4P CoA-binding domain protein HVY57_RS00465 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVY57_RS00470 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVY57_RS00475 ENOG4108MN8 Membrane HVY57_RS00490 ENOG4105E3S small subunit HVY57_RS00495 ENOG4105DPX Hydrogenase, large subunit HVY57_RS00500 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVY57_RS00505 ENOG4108USZ hydrogenase HVY57_RS00510 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVY57_RS00515 ENOG4105MVP hydrogenase-1 operon protein HyaF HVY57_RS00520 ENOG4106RHG Yeca family HVY57_RS00525 ENOG4105E0U tyrosine-specific transport protein HVY57_RS00530 ENOG4105VVZ metal-binding protein HVY57_RS00535 ENOG41090A1 ferritin HVY57_RS00540 ENOG4105P23 (LipO)protein HVY57_RS00545 ENOG4108UEC Ferritin-like protein HVY57_RS00595 ENOG410600T transposase HVY57_RS00600 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVY57_RS00605 ENOG4105C2J ABC transporter HVY57_RS00610 ENOG4105CNN ABC, transporter HVY57_RS00615 ENOG4108K4C ec 3.1.3.12 HVY57_RS00625 ENOG4108VA4 Universal stress protein HVY57_RS00635 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVY57_RS00640 ENOG4107RD7 Flagellar Motor Protein, MotA HVY57_RS00645 ENOG4105ER2 Ompa motb domain protein HVY57_RS00650 ENOG4105CBS Chea signal transduction histidine kinase HVY57_RS00655 ENOG4108V3W Chemotaxis protein, CheW HVY57_RS00685 ENOG4105C8Q Methyl-accepting chemotaxis HVY57_RS00690 ENOG4105BZU Histidine kinase HVY57_RS00700 ENOG4108VYJ response regulator receiver protein HVY57_RS00725 ENOG4105MWK D-amino acid dehydrogenase, small subunit HVY57_RS00730 ENOG4105RQF LysR family Transcriptional regulator HVY57_RS00740 ENOG4105D6F Phosphatase HVY57_RS00745 ENOG4105XH3 HVY57_RS00755 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVY57_RS00760 ENOG4108R86 Transcriptional regulator HVY57_RS00765 ENOG4105BZU Histidine kinase HVY57_RS00770 ENOG41064RH membrane protein YliF HVY57_RS00775 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY57_RS00780 ENOG4107EEX Cellulose synthase regulator protein HVY57_RS00795 ENOG4108W9D (LipO)protein HVY57_RS00800 ENOG4105E5K Alpha-amylase HVY57_RS00805 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HVY57_RS00810 ENOG4105MQ3 flagellar protein FliS HVY57_RS00815 ENOG4105DTS flagellar hook-associated HVY57_RS00825 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY57_RS00830 ENOG4108M9K flagella biosynthesis protein FliZ HVY57_RS00835 ENOG4105EAB amino acid AbC transporter HVY57_RS00845 ENOG4105E5Q amino acid AbC transporter HVY57_RS00850 ENOG4105CDA abc transporter atp-binding protein HVY57_RS00855 ENOG4105VJY transcriptional regulator HVY57_RS00860 ENOG4105XVG cytoplasmic protein HVY57_RS00865 ENOG4105WH1 Two component transcriptional regulator luxr family HVY57_RS00900 ENOG4107SVH Potassium channel protein HVY57_RS00920 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY57_RS00935 ENOG4105BZU Histidine kinase HVY57_RS00940 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVY57_RS00945 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVY57_RS00950 ENOG4105CUW cytochrome C-TYPE protein HVY57_RS00955 ENOG4107QY8 reductase HVY57_RS00965 ENOG4105D00 flagellar biosynthetic protein flhB HVY57_RS00970 ENOG4105D7B Flagellar biosynthesis protein flha HVY57_RS00975 ENOG4105W13 flagellar protein HVY57_RS00990 ENOG4106ZCM YecM protein HVY57_RS01010 ENOG4105WJG Glutathione HVY57_RS01015 ENOG41081XQ Conserved Protein HVY57_RS01020 ENOG4105D3W isochorismatase HVY57_RS01030 ENOG4108TIT dATP pyrophosphohydrolase HVY57_RS01035 ENOG4105CDY transcriptional regulatory protein HVY57_RS01045 ENOG4107S01 Repressor protein MetJ HVY57_RS01065 ENOG4105FAV ABC, transporter HVY57_RS01075 ENOG4105NXV High-affinity zinc uptake system protein HVY57_RS01080 ENOG4105DR5 peptidase HVY57_RS01085 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVY57_RS01090 ENOG4105CA9 Pyruvate kinase HVY57_RS01095 ENOG4106KNT transcriptional regulator HVY57_RS01100 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVY57_RS01105 ENOG4105C01 Dihydroxy-acid dehydratase HVY57_RS01110 ENOG4108UHU Aldolase HVY57_RS01115 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HVY57_RS01120 ENOG4105X2V dna damage-inducible protein HVY57_RS01130 ENOG4108Q2J Inner membrane protein YebE HVY57_RS01135 ENOG4105CUG Oligopeptidase b HVY57_RS01140 ENOG4105UMD exodeoxyribonuclease X HVY57_RS01145 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY57_RS01150 ENOG4105MPK DNA polymerase III subunit theta HVY57_RS01155 ENOG4105FXM Copper resistance protein HVY57_RS01160 ENOG4108PNC copper resistance HVY57_RS01165 ENOG4105NKT exported protein HVY57_RS01170 ENOG4108R1E Serine threonine protein phosphatase 1 HVY57_RS01175 ENOG4105UVW uncharacterized protein yebW HVY57_RS01180 ENOG4105WT8 Protein of unknown function (DUF1480) HVY57_RS01190 ENOG4105DY2 Paraquat-inducible protein b HVY57_RS01195 ENOG4105H2K paraquat-inducible protein a HVY57_RS01200 ENOG4108ZGC gaf domain protein HVY57_RS01210 ENOG4105CN1 protease HVY57_RS01220 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY57_RS01225 ENOG4105J4Q Transcriptional regulator HVY57_RS01230 ENOG4105TIK HVY57_RS01240 ENOG4105Q3Y exported protein HVY57_RS01255 ENOG4105DHI Methyltransferase HVY57_RS01270 ENOG4105F3R pts system mannose fructose sorbose family iid HVY57_RS01275 ENOG4105ETZ PTS System HVY57_RS01280 ENOG4105DAS pts system HVY57_RS01285 ENOG4105EE5 Membrane protein terC HVY57_RS01290 ENOG4107XTP (EAL) domain protein HVY57_RS01295 ENOG4105EJQ L-serine dehydratase HVY57_RS01305 ENOG4105CRQ synthase (Component I) HVY57_RS01320 ENOG4105V2F Uncharacterized protein yoac HVY57_RS01325 ENOG4105M4H endoribonuclease L-psp HVY57_RS01340 ENOG4105DVT helicase HVY57_RS01345 ENOG41072GX Peptidase M22 Glycoprotease HVY57_RS01350 ENOG4105Y4Z Outer Membrane Lipoprotein HVY57_RS01355 ENOG4105CEY Amp-dependent synthetase and ligase HVY57_RS01360 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVY57_RS01365 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY57_RS01370 ENOG4108JA2 transcriptioN-repair coupling factor HVY57_RS01375 ENOG4105IQC Inner membrane protein YcfT HVY57_RS01380 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY57_RS01385 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVY57_RS01390 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY57_RS01400 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVY57_RS01415 ENOG4107RUE extracellular solute-binding protein family 1 HVY57_RS01420 ENOG4105D38 putrescine abc transporter HVY57_RS01440 ENOG4105DSB aldose 1-epimerase HVY57_RS01455 ENOG4105VUT cytoplasmic protein HVY57_RS01460 ENOG4108RWI nicotinamidase HVY57_RS01465 ENOG4105HDK L-asparaginase HVY57_RS01475 ENOG4105D07 Signal peptide peptidase, SppA HVY57_RS01480 ENOG41069NU Nitroreductase HVY57_RS01490 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY57_RS01495 ENOG41065FB inner membrane protein ynji HVY57_RS01500 ENOG4105D82 Glutamate dehydrogenase HVY57_RS01505 ENOG4105MTM Protein of unknown function (DUF1496) HVY57_RS01510 ENOG4105M6F mutator MutT protein HVY57_RS01515 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVY57_RS01520 ENOG4107RM6 sulfurtransferase HVY57_RS01525 ENOG4108VGW abc transporter atp-binding protein HVY57_RS01530 ENOG4105CXZ ABC transporter, permease HVY57_RS01535 ENOG4105VNH ABC transporter solute-binding protein HVY57_RS01540 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY57_RS01545 ENOG4108N5C SNARE associated Golgi protein-related protein HVY57_RS01550 ENOG4108RSN SNARE associated Golgi HVY57_RS01555 ENOG4105CGK Exodeoxyribonuclease III HVY57_RS01585 ENOG4108SPG Periplasmic Protein HVY57_RS01595 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVY57_RS01605 ENOG4105KKI DNA-binding transcriptional activator OsmE HVY57_RS01610 ENOG4105VZJ PTS System HVY57_RS01615 ENOG4105CK1 PTS System HVY57_RS01620 ENOG4105VCP PTS System HVY57_RS01625 ENOG4105EZV Transcriptional regulator HVY57_RS01635 ENOG4105F8D glycoside hydrolase family 4 HVY57_RS01645 ENOG4105CH6 catalase HVY57_RS01650 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HVY57_RS01655 ENOG4108ETY sodium dicarboxylate symporter HVY57_RS01660 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVY57_RS01665 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVY57_RS01670 ENOG4107PN8 YfeABCD locus regulator HVY57_RS01680 ENOG4105P10 Uncharacterized protein ydiZ HVY57_RS01685 ENOG4105DE4 1-phosphofructokinase HVY57_RS01690 ENOG4108NE3 Salt-induced outer membrane protein HVY57_RS01705 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVY57_RS01710 ENOG41082NX 50s ribosomal protein l35 HVY57_RS01765 ENOG4107RNI Glucose 6-phosphate dehydrogenase effector OpcA HVY57_RS01810 ENOG4105UZW Tail fiber assembly protein HVY57_RS01820 ENOG410685N tail fiber protein HVY57_RS01900 ENOG4105ED4 portal protein HVY57_RS01910 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HVY57_RS01970 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY57_RS01985 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HVY57_RS01990 ENOG4108QBX (LipO)protein HVY57_RS02010 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY57_RS02020 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVY57_RS02025 ENOG4105SUA Ydil protein HVY57_RS02035 ENOG4105IPI Membrane HVY57_RS02040 ENOG4105CQB FAD linked oxidase domain protein HVY57_RS02045 ENOG4105KA0 thioesterase Superfamily protein HVY57_RS02050 ENOG410671Z uncharacterized protein ydiH HVY57_RS02055 ENOG4108Z4V iron-sulfur cluster assembly HVY57_RS02060 ENOG4105DIW FeS assembly protein SUFB HVY57_RS02065 ENOG4105C3K feS assembly ATPase SufC HVY57_RS02070 ENOG4105JRK feS assembly protein SufD HVY57_RS02085 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY57_RS02090 ENOG4105KMX major outer membrane lipoprotein HVY57_RS02095 ENOG4105CA9 Pyruvate kinase HVY57_RS02100 ENOG4105RFR Protein of unknown function (DUF2767) HVY57_RS02120 ENOG4105N0V mono-oxygenase ydhR HVY57_RS02140 ENOG4108R6K riboflavin synthase, subunit alpha HVY57_RS02145 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVY57_RS02150 ENOG4105CZQ inner membrane transport protein YdhC HVY57_RS02155 ENOG4105F52 Transcriptional regulator HVY57_RS02170 ENOG4105F27 Major Facilitator HVY57_RS02175 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY57_RS02180 ENOG4105K4H Nlp p60 protein HVY57_RS02185 ENOG4105M2J Glutaredoxin HVY57_RS02190 ENOG4107QRT dEAD DEAH box helicase HVY57_RS02195 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HVY57_RS02200 ENOG4108UYE Lactoylglutathione lyase HVY57_RS02205 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY57_RS02210 ENOG4108WUH Transcriptional regulator, TetR family HVY57_RS02215 ENOG4105XZD Fe-S protein HVY57_RS02220 ENOG4107RGM aldo keto reductase HVY57_RS02225 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY57_RS02230 ENOG4105DSW Fusaric acid resistance protein HVY57_RS02235 ENOG4105Y49 secretion protein, HlyD family HVY57_RS02250 ENOG4108XTF Outer Membrane Lipoprotein HVY57_RS02260 ENOG410642K Lysozyme inhibitor HVY57_RS02275 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVY57_RS02280 ENOG4108K3A Glutathione S-transferase HVY57_RS02285 ENOG4105DUX Transporter HVY57_RS02290 ENOG4105CSM endonuclease III HVY57_RS02300 ENOG4108UQQ Electron transport complex HVY57_RS02325 ENOG4105M9B inner membrane protein ydgK HVY57_RS02330 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVY57_RS02335 ENOG4106C6R beta-lactam resistance protein HVY57_RS02340 ENOG4105D9R oxidoreductase HVY57_RS02350 ENOG4105C87 Aminotransferase class I and II HVY57_RS02360 ENOG4106J39 exported protein HVY57_RS02365 ENOG4105EIP mannose-6-phosphate isomerase HVY57_RS02370 ENOG4107GFK fumarate HVY57_RS02375 ENOG4105C9Q fumarate hydratase class II HVY57_RS02385 ENOG4105JJR Histidine kinase HVY57_RS02390 ENOG4107EXC regulatoR HVY57_RS02395 ENOG4105RA2 Membrane HVY57_RS02405 ENOG4105D5Q Arginine ornithine antiporter HVY57_RS02410 ENOG4105C5D exported protein HVY57_RS02415 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY57_RS02420 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY57_RS02425 ENOG4105BZU Histidine kinase HVY57_RS02430 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVY57_RS02445 ENOG4105D94 Major Facilitator Superfamily HVY57_RS02450 ENOG4106NZI LysR family Transcriptional regulator HVY57_RS02455 ENOG4105DAG ROK family HVY57_RS02460 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY57_RS02465 ENOG4105CMQ Chloride channel HVY57_RS02470 ENOG4108IJ8 ABC transporter HVY57_RS02475 ENOG4105E90 ABC transporter HVY57_RS02480 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVY57_RS02485 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HVY57_RS02490 ENOG4105R71 cytoplasmic protein HVY57_RS02495 ENOG4108T9Y Inner membrane protein ydcZ HVY57_RS02500 ENOG4108Z7F N-acetyltransferase HVY57_RS02505 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVY57_RS02510 ENOG4108WYP Transcriptional regulator HVY57_RS02515 ENOG4105CHB tonB-dependent Receptor HVY57_RS02520 ENOG4108NS2 receptor HVY57_RS02525 ENOG4105C85 amino acid HVY57_RS02530 ENOG4108N27 Glutathione S-transferase HVY57_RS02535 ENOG410600T transposase HVY57_RS02555 ENOG410600T transposase HVY57_RS02580 ENOG4105JAB phenazine biosynthesis protein, phzf family HVY57_RS02585 ENOG4105DIA mandelate racemase muconate lactonizing HVY57_RS02600 ENOG4108MEJ flavin reductase domain protein HVY57_RS02605 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVY57_RS02610 ENOG4107HP6 Transcriptional regulator HVY57_RS02615 ENOG4105DTQ mandelate racemase muconate lactonizing HVY57_RS02620 ENOG4105NN7 muconolactone delta-isomerase HVY57_RS02625 ENOG410626B catechol 1,2-dioxygenase HVY57_RS02655 ENOG4105FCK Membrane HVY57_RS02660 ENOG4105RPH Inner membrane protein YddG HVY57_RS02670 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY57_RS02675 ENOG4108MG3 formate dehydrogenase HVY57_RS02680 ENOG41084S7 Plasmid maintenance system antidote protein HVY57_RS02690 ENOG4105DQ4 alcohol dehydrogenase HVY57_RS02700 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVY57_RS02705 ENOG4105TPS biofilm-dependent modulation protein HVY57_RS02710 ENOG4108Z9K Osmotically inducible protein HVY57_RS02720 ENOG4105DDW LysR family Transcriptional regulator HVY57_RS02725 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HVY57_RS02730 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HVY57_RS02735 ENOG4105E32 cytoplasmic protein HVY57_RS02745 ENOG4105Z2P Protein of unknown function (DUF465) HVY57_RS02750 ENOG4108Z9I -acetyltransferase HVY57_RS02755 ENOG4107WE3 acetyltransferase YdcK HVY57_RS02760 ENOG41088CC tellurite resistance protein tehB HVY57_RS02765 ENOG4108KKZ (LipO)protein HVY57_RS02770 ENOG4105CFP Peptidase U32 HVY57_RS02780 ENOG4105RR0 Protein of unknown function (DUF2554) HVY57_RS02785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY57_RS02790 ENOG4107TYH extracellular solute-binding protein family 1 HVY57_RS02795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY57_RS02800 ENOG4105D81 ABC transporter, permease HVY57_RS02805 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVY57_RS02820 ENOG410654E Membrane HVY57_RS02825 ENOG4105KBG Protein of unknown function (DUF1161) HVY57_RS02835 ENOG4108MK9 spermidine N(1)-acetyltransferase HVY57_RS02850 ENOG4105CXK mandelate racemase muconate lactonizing HVY57_RS02855 ENOG4105CPQ Dehydrogenase HVY57_RS02860 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVY57_RS02870 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY57_RS02880 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY57_RS02885 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY57_RS02895 ENOG4105DEI Mannitol dehydrogenase HVY57_RS02900 ENOG41061EV selenium-binding protein YdfZ HVY57_RS02905 ENOG4107XBN GntR Family Transcriptional Regulator HVY57_RS02910 ENOG4105EMU Dehydrogenase HVY57_RS02915 ENOG4105DGW oligopeptidase A HVY57_RS02920 ENOG4108WTK competence damage-inducible protein HVY57_RS02925 ENOG4108YDI single-species biofilm formation on inanimate substrate HVY57_RS02930 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVY57_RS02935 ENOG4105E5W Transporter HVY57_RS02940 ENOG4108594 Permease of the drug metabolite transporter HVY57_RS02945 ENOG4106DNR multiple antibiotic resistance protein HVY57_RS02950 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVY57_RS02955 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVY57_RS02970 ENOG4105EGI Transcriptional regulator HVY57_RS02975 ENOG4105C26 Dehydrogenase HVY57_RS02980 ENOG4105CSV Glutaminase HVY57_RS02985 ENOG4105M0C cytoplasmic protein HVY57_RS02990 ENOG4105BZU Histidine kinase HVY57_RS03000 ENOG4105FFC UPF0187 protein HVY57_RS03010 ENOG4105D7V transposase HVY57_RS03020 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVY57_RS03065 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HVY57_RS03070 ENOG4105F9F transposase HVY57_RS03080 ENOG4108R6W Transcriptional regulator, ARAC family HVY57_RS03085 ENOG4106PHM regulatory protein HVY57_RS03100 ENOG4105CQ0 ABC transporter HVY57_RS03105 ENOG4105PE1 Receptor HVY57_RS03110 ENOG4107RAN Peptidase, M16 HVY57_RS03115 ENOG4105CVK Glutamate decarboxylase HVY57_RS03120 ENOG4105E5D amino acid HVY57_RS03125 ENOG4105F32 YngK protein HVY57_RS03135 ENOG4105F2I Transposase HVY57_RS03145 ENOG4105BZU Histidine kinase HVY57_RS03160 ENOG4105CPW cytochrome b561 HVY57_RS03165 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVY57_RS03170 ENOG4107DB1 DUF218 domain HVY57_RS03200 ENOG4105CQ7 ATP-dependent helicase HVY57_RS03210 ENOG41077RS Phosphatase HVY57_RS03215 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVY57_RS03220 ENOG4108HPI phosphatidate Cytidylyltransferase HVY57_RS03225 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVY57_RS03235 ENOG4107S5I aldo keto reductase HVY57_RS03240 ENOG4108Z0R Transferase HVY57_RS03245 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVY57_RS03250 ENOG4105DZS Phenylacetate-CoA ligase HVY57_RS03255 ENOG4105CHU acetyl-coa acetyltransferase HVY57_RS03260 ENOG4108ZJI phenylacetic acid degradation protein HVY57_RS03265 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVY57_RS03270 ENOG4108UKI Enoyl-CoA hydratase HVY57_RS03275 ENOG4105E39 Enoyl-CoA hydratase HVY57_RS03280 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY57_RS03285 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVY57_RS03290 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVY57_RS03295 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVY57_RS03300 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVY57_RS03305 ENOG4105DXM phenylacetic acid degradation protein HVY57_RS03310 ENOG4105F11 amine oxidase HVY57_RS03315 ENOG4105C26 Dehydrogenase HVY57_RS03320 ENOG4108WFR AraC Family Transcriptional Regulator HVY57_RS03330 ENOG4105WXT Conserved Protein HVY57_RS03335 ENOG410689M (LipO)protein HVY57_RS03340 ENOG4107H52 Dicarboxylate transport HVY57_RS03345 ENOG4105C5I Dehydrogenase HVY57_RS03350 ENOG41090X5 Heat shock protein hslJ HVY57_RS03355 ENOG4105IKK cytoplasmic protein HVY57_RS03365 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVY57_RS03370 ENOG4105FCK Membrane HVY57_RS03375 ENOG4108RW8 Universal stress protein F HVY57_RS03385 ENOG4105C1J atp-dependent rna helicase HVY57_RS03400 ENOG4105BZU Histidine kinase HVY57_RS03405 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HVY57_RS03410 ENOG4105F2Z 3-oxoadipate enol-lactonase HVY57_RS03415 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HVY57_RS03420 ENOG4105CHU acetyl-coa acetyltransferase HVY57_RS03425 ENOG4107QNJ CoA-transferase subunit B HVY57_RS03435 ENOG4107HP6 Transcriptional regulator HVY57_RS03440 ENOG4108DG9 Smr protein MutS2 HVY57_RS03445 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY57_RS03450 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVY57_RS03455 ENOG4105Q9Y Universal stress protein HVY57_RS03460 ENOG4105S5I Membrane HVY57_RS03465 ENOG4105D64 Mechanosensitive ion channel HVY57_RS03470 ENOG4107QSI ABC, transporter HVY57_RS03475 ENOG4105KXI murein peptide amidase A HVY57_RS03480 ENOG4107S8C mandelate racemase muconate lactonizing HVY57_RS03485 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVY57_RS03490 ENOG4108JU8 Transcriptional regulator HVY57_RS03500 ENOG4105CM6 amino acid regulated cytosolic protein HVY57_RS03505 ENOG4105FKQ transcriptional regulator HVY57_RS03510 ENOG4107EFV Outer membrane protein G HVY57_RS03515 ENOG4108IJ9 (ABC) transporter HVY57_RS03520 ENOG4107URF beta-phospho-glucomutase HVY57_RS03530 ENOG4105CK5 oxidoreductase HVY57_RS03535 ENOG4107TYA transient receptor potential locus HVY57_RS03540 ENOG4107RRD Dehydrogenase HVY57_RS03545 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HVY57_RS03550 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HVY57_RS03555 ENOG4105WEM extracellular solute-binding protein HVY57_RS03560 ENOG4107QW3 Sucrose phosphorylase HVY57_RS03565 ENOG4105K8Z Phage shock protein HVY57_RS03570 ENOG4105NNG Peripheral inner membrane phage-shock protein HVY57_RS03575 ENOG4105FM1 phage shock protein C HVY57_RS03580 ENOG4105YYT phage shock protein B HVY57_RS03585 ENOG41087YS Phage shock protein A HVY57_RS03590 ENOG4105E51 psp operon transcriptional activator HVY57_RS03595 ENOG4108HIY periplasmic HVY57_RS03600 ENOG4108I5W peptide transport system, permease protein HVY57_RS03605 ENOG4108EU3 peptide transport system, permease HVY57_RS03610 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVY57_RS03615 ENOG4108JQ2 peptide transport system atp-binding protein HVY57_RS03620 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVY57_RS03625 ENOG4105Q4T oxidoreductase HVY57_RS03635 ENOG4105BZU Histidine kinase HVY57_RS03645 ENOG4105N2W Transcriptional regulator HVY57_RS03655 ENOG4108ZJT translation initiation factor, Sui1 HVY57_RS03665 ENOG4105CFV Tetratricopeptide repeat protein HVY57_RS03670 ENOG4105Q4A inner membrane protein yciS HVY57_RS03675 ENOG4105EYK Phosphatidylglycerophosphatase B HVY57_RS03685 ENOG4107QM5 aconitate hydratase HVY57_RS03700 ENOG4107R11 Transcriptional regulator HVY57_RS03705 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY57_RS03710 ENOG4105RKX Protein of unknown function (DUF2498) HVY57_RS03715 ENOG4105ERU peptidase HVY57_RS03720 ENOG4105UBK short-chain dehydrogenase reductase HVY57_RS03725 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVY57_RS03730 ENOG4105FE9 pseudouridine synthase HVY57_RS03735 ENOG4105EG3 transmembrane signal peptide protein HVY57_RS03740 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVY57_RS03745 ENOG4105DB7 PHP domain protein HVY57_RS03755 ENOG4105CRQ synthase (Component I) HVY57_RS03760 ENOG4108EFP Anthranilate synthase component II HVY57_RS03765 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVY57_RS03780 ENOG4105EIF outer membrane protein W HVY57_RS03785 ENOG4105PI0 Ferredoxin HVY57_RS03800 ENOG4105NAU thioesterase Superfamily protein HVY57_RS03805 ENOG410822N TonB family HVY57_RS03810 ENOG4105K9H YciI-like protein HVY57_RS03830 ENOG4105EYW Ion transport protein HVY57_RS03835 ENOG4108JQ7 (ABC) transporter HVY57_RS03840 ENOG4105C3U ABC transporter HVY57_RS03845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY57_RS03850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY57_RS03855 ENOG4107QSI ABC, transporter HVY57_RS03860 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVY57_RS03865 ENOG4105C0A alcohol dehydrogenase HVY57_RS03875 ENOG4107104 thymidine kinase HVY57_RS03885 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY57_RS03890 ENOG4105I93 response regulator HVY57_RS03895 ENOG4105D78 K07001 NTE family protein HVY57_RS03905 ENOG4105CIY formyltetrahydrofolate deformylase HVY57_RS03950 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY57_RS03955 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVY57_RS03960 ENOG41076YT nitrate reductase, gamma subunit HVY57_RS03965 ENOG4105R3A Nitrate reductase HVY57_RS03970 ENOG4108IUE nitrate reductase beta subunit HVY57_RS03975 ENOG4105CRU nitrate reductase, alpha subunit HVY57_RS03980 ENOG4105DQQ Major facilitator superfamily MFS_1 HVY57_RS03985 ENOG4105BZU Histidine kinase HVY57_RS03990 ENOG4105WH1 Two component transcriptional regulator luxr family HVY57_RS03995 ENOG4105ID0 Putative invasin HVY57_RS04000 ENOG41090EX DsrE family HVY57_RS04005 ENOG4108NH8 Cation transport protein HVY57_RS04010 ENOG4105WS7 Cation transport regulator HVY57_RS04015 ENOG4105EWV Sodium calcium exchanger membrane region HVY57_RS04030 ENOG41063JG Transcriptional regulator HVY57_RS04035 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVY57_RS04060 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVY57_RS04065 ENOG4105CHH sulfate transporter HVY57_RS04070 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVY57_RS04080 ENOG4105C3G gtp-binding protein HVY57_RS04085 ENOG4105E53 ec 3.2.1.28 HVY57_RS04100 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVY57_RS04110 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVY57_RS04120 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY57_RS04130 ENOG4105ED1 spovr family HVY57_RS04145 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVY57_RS04170 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVY57_RS04185 ENOG4107QMS site-determining protein HVY57_RS04195 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY57_RS04200 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY57_RS04205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY57_RS04215 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVY57_RS04235 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVY57_RS04240 ENOG4105CDY transcriptional regulatory protein HVY57_RS04255 ENOG4108HMX isocitrate dehydrogenase (NADP) HVY57_RS04280 ENOG4107QTF adenylosuccinate lyase HVY57_RS04285 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY57_RS04290 ENOG4105IFJ Histidine kinase HVY57_RS04295 ENOG4105EZE Cupin 4 family protein HVY57_RS04300 ENOG4105CV8 reductase HVY57_RS04305 ENOG4105GNX MltA-interacting MipA family protein HVY57_RS04310 ENOG4105CYN Serine protein kinase HVY57_RS04320 ENOG4106KTS Inner membrane protein yeaI HVY57_RS04325 ENOG4108KHP Diguanylate cyclase HVY57_RS04330 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVY57_RS04345 ENOG4105DJ2 Major Facilitator Superfamily HVY57_RS04350 ENOG4105K78 MarR family Transcriptional regulator HVY57_RS04355 ENOG4105UCG Domain of unknown function (DUF333) HVY57_RS04360 ENOG410620I Diguanylate cyclase HVY57_RS04365 ENOG4106G4W HVY57_RS04375 ENOG4105Y3U Transglycosylase-associated protein HVY57_RS04385 ENOG4107MBR 17 kDa surface antigen HVY57_RS04390 ENOG4105CEP NADH dehydrogenase HVY57_RS04405 ENOG4108RUM thiamine kinase HVY57_RS04410 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVY57_RS04415 ENOG41090DQ Lipoprotein HVY57_RS04420 ENOG4105K59 histidine triad (HIT) protein HVY57_RS04425 ENOG4105CI1 PTS System HVY57_RS04430 ENOG4105F8V Hydrolase, tatD family HVY57_RS04435 ENOG4107QRG dna polymerase iii HVY57_RS04445 ENOG4105HHA aminodeoxychorismate lyase HVY57_RS04450 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVY57_RS04455 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY57_RS04460 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVY57_RS04465 ENOG4105CHR reductase HVY57_RS04470 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVY57_RS04475 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVY57_RS04485 ENOG4105VGS 50s ribosomal protein l32 HVY57_RS04490 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVY57_RS04495 ENOG4108UHJ MAF-like protein HVY57_RS04500 ENOG4105EI2 Pseudouridine synthase HVY57_RS04505 ENOG4107QQB Ribonuclease E HVY57_RS04510 ENOG4105DTJ flagellar hook-associated protein HVY57_RS04515 ENOG4105E1Q flagellar hook-associated protein HVY57_RS04520 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVY57_RS04535 ENOG4105CGA flagellar basal-body rod protein FlgG HVY57_RS04540 ENOG4108KPB Flagellar basal-body rod protein FlgF HVY57_RS04545 ENOG4105BZE flagellar hook protein, FlgE HVY57_RS04550 ENOG4105W00 Flagellar hook capping protein HVY57_RS04555 ENOG4108ZC9 flagellar basal-body rod protein flgc HVY57_RS04560 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVY57_RS04565 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVY57_RS04570 ENOG4105M9M anti-sigma28 factor FlgM HVY57_RS04575 ENOG4105QVD Flagella synthesis protein FlgN HVY57_RS04580 ENOG4105CJR Integral membrane protein (MviN HVY57_RS04585 ENOG4105EP9 oxidoreductase HVY57_RS04595 ENOG4105D9U N-acetyltransferase HVY57_RS04605 ENOG4105F3T (LipO)protein HVY57_RS04615 ENOG4105MEA DNA damage-inducible protein i HVY57_RS04620 ENOG4105PVA Biofilm formation regulatory protein BssS HVY57_RS04630 ENOG4105DS1 cytochrome b561 HVY57_RS04635 ENOG4108YYC ycei family HVY57_RS04645 ENOG4105D1S lipid A biosynthesis HVY57_RS04655 ENOG4108W47 Acidic protein msyB HVY57_RS04660 ENOG4105NAC (LipO)protein HVY57_RS04665 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVY57_RS04675 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HVY57_RS04680 ENOG4107RZC phospholipase d HVY57_RS04695 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HVY57_RS04700 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVY57_RS04705 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVY57_RS04710 ENOG41086KC Transcriptional regulator HVY57_RS04715 ENOG4108XDW curli assembly protein CsgE HVY57_RS04720 ENOG4108WYR Curli production assembly transport component, CsgF HVY57_RS04725 ENOG4105P8Q Curli production assembly transport component CsgG HVY57_RS04730 ENOG4108UQ5 membrane protein YcdZ HVY57_RS04735 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVY57_RS04775 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVY57_RS04790 ENOG4108YGG dna repair protein HVY57_RS04795 ENOG4105MFG Antirestriction protein HVY57_RS04800 ENOG4106H6R UPF0380 protein HVY57_RS04805 ENOG4105F4K antigen 43 HVY57_RS04830 ENOG4105F2I Transposase HVY57_RS04840 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVY57_RS04845 ENOG4107QR9 Iron-sulfur cluster binding protein HVY57_RS04850 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY57_RS04855 ENOG4105CXG d-lactate dehydrogenase HVY57_RS04875 ENOG4108K01 transcriptional regulator HVY57_RS04880 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY57_RS04885 ENOG41066GK UPF0379 protein ykgI HVY57_RS04890 ENOG4108KBJ Inner membrane protein YkgB HVY57_RS04945 ENOG4105DFP Integrase HVY57_RS04950 ENOG4105CRK lysyL-tRNA synthetase HVY57_RS04955 ENOG4105DUX Transporter HVY57_RS04960 ENOG4105CXN decarboxylase HVY57_RS04965 ENOG4105D5Q Arginine ornithine antiporter HVY57_RS04970 ENOG4108M3R transcriptional activator CadC HVY57_RS04975 ENOG4105BZU Histidine kinase HVY57_RS04980 ENOG4108TUY outer membrane protein PgaA HVY57_RS04985 ENOG4107BJW polysaccharide deacetylase HVY57_RS04990 ENOG4105CND Glycosyl transferase, family 2 HVY57_RS05000 ENOG4105D5M phosphate starvation-inducible protein HVY57_RS05005 ENOG4105DBE peroxidase HVY57_RS05010 ENOG410650H (LipO)protein HVY57_RS05020 ENOG4105CK7 Sodium proline symporter HVY57_RS05030 ENOG4105C26 Dehydrogenase HVY57_RS05035 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVY57_RS05040 ENOG4108MJ5 VirK protein HVY57_RS05050 ENOG4107BJW polysaccharide deacetylase HVY57_RS05055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVY57_RS05060 ENOG4105KT5 UmuD protein HVY57_RS05065 ENOG4105EKQ RNA-directed DNA polymerase HVY57_RS05075 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVY57_RS05080 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY57_RS05085 ENOG41090PJ Flagellar assembly protein HVY57_RS05090 ENOG4108JIR Flagellum-specific ATP synthase HVY57_RS05095 ENOG4105GSA Flagellar export protein flij HVY57_RS05100 ENOG4105WF4 Flagellar hook-length control protein HVY57_RS05105 ENOG4107ZI8 flagellar basal body-associated protein flil HVY57_RS05110 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY57_RS05115 ENOG4105DD5 Flagellar motor switch protein HVY57_RS05120 ENOG4105K0P flagellar biosynthesis protein HVY57_RS05125 ENOG4105CN7 Flagellar biosynthetic protein FliP HVY57_RS05130 ENOG4105VS8 Flagellar biosynthetic protein fliq HVY57_RS05135 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVY57_RS05140 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVY57_RS05150 ENOG4105YX3 cellular response to acidity HVY57_RS05165 ENOG4105VNZ cytoplasmic protein HVY57_RS05170 ENOG4105CKW Inner membrane protein yedI HVY57_RS05175 ENOG4105FDR Membrane HVY57_RS05180 ENOG41090BB DNA mismatch endonuclease (vsr) HVY57_RS05185 ENOG4105EST Metal Dependent Phosphohydrolase HVY57_RS05190 ENOG4105Y0K Inner membrane protein YedR HVY57_RS05195 ENOG4105ZIT Porin Gram-negative type HVY57_RS05205 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY57_RS05230 ENOG4108X9F tail fiber protein HVY57_RS05320 ENOG4105EFC phage portal protein HK97 family HVY57_RS05355 ENOG4105NVB glycoside hydrolase, family 19 HVY57_RS05380 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVY57_RS05385 ENOG4108MXB Protein of unknown function (DUF968) HVY57_RS05405 ENOG4105WPN DNA integration recombination invertion protein HVY57_RS05415 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HVY57_RS05465 ENOG4106G8A Qin prophage HVY57_RS05500 ENOG4107R11 Transcriptional regulator HVY57_RS05545 ENOG4105GMB type VI secretion system effector, hcp1 family HVY57_RS05575 ENOG4108WC9 type VI secretion system effector, hcp1 family HVY57_RS05605 ENOG410600T transposase HVY57_RS05625 ENOG4105FYV Amp nucleosidase HVY57_RS05630 ENOG4105CSH Transporter HVY57_RS05640 ENOG4105UQX Mate efflux family protein HVY57_RS05665 ENOG4105KNY Microcompartments protein HVY57_RS05670 ENOG4105KNY Microcompartments protein HVY57_RS05675 ENOG4105KNY Microcompartments protein HVY57_RS05680 ENOG4105C0A alcohol dehydrogenase HVY57_RS05690 ENOG4105C0A alcohol dehydrogenase HVY57_RS05695 ENOG4105C6N Formate acetyltransferase HVY57_RS05700 ENOG4105F1A Pyruvate formate-lyase HVY57_RS05705 ENOG4105KNY Microcompartments protein HVY57_RS05710 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVY57_RS05730 ENOG4108PXI ErfK YbiS YcfS YnhG HVY57_RS05735 ENOG4108P62 biosynthesis protein (CbiG) HVY57_RS05745 ENOG4107XVH Transcriptional regulator HVY57_RS05750 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY57_RS05755 ENOG4105KNY Microcompartments protein HVY57_RS05760 ENOG4105EHR propanediol utilization protein pduB HVY57_RS05765 ENOG4105DMB glycerol dehydratase HVY57_RS05770 ENOG4105YCI dehydratase medium subunit HVY57_RS05775 ENOG4108ZFT Dehydratase small subunit HVY57_RS05780 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVY57_RS05790 ENOG4105KNY Microcompartments protein HVY57_RS05810 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVY57_RS05820 ENOG4108EKI Dehydrogenase HVY57_RS05830 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVY57_RS05840 ENOG4105M3W utilization protein HVY57_RS05845 ENOG4105KTW ethanolamine utilization protein HVY57_RS05860 ENOG4105DR8 Membrane HVY57_RS05890 ENOG4105CJB Exodeoxyribonuclease I HVY57_RS05900 ENOG4105CUC YeeE YedE family protein HVY57_RS05905 ENOG4105CUB amino acid HVY57_RS05915 ENOG4105EQ1 Transcriptional regulator HVY57_RS05920 ENOG4107SRH Nad-dependent epimerase dehydratase HVY57_RS05925 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVY57_RS05930 ENOG4105VTW prevent-host-death family HVY57_RS05945 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVY57_RS05950 ENOG4105CIH Imidazole acetol-phosphate transaminase HVY57_RS05955 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVY57_RS05960 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVY57_RS05990 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVY57_RS05995 ENOG4107QKV phosphomannomutase HVY57_RS06000 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVY57_RS06035 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVY57_RS06040 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY57_RS06045 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVY57_RS06050 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY57_RS06055 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY57_RS06060 ENOG4105G1A colanic acid biosynthesis protein HVY57_RS06065 ENOG4107T8Q Glycosyl transferase (Group 1 HVY57_RS06070 ENOG4105C74 pyruvyl transferase HVY57_RS06075 ENOG4105PSV Polysaccharide Biosynthesis Protein HVY57_RS06080 ENOG4105D3Q Sugar transferase HVY57_RS06085 ENOG4107QKV phosphomannomutase HVY57_RS06090 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVY57_RS06095 ENOG4106CD9 glycosyl transferase group 1 HVY57_RS06100 ENOG4105FGF GDP-mannose mannosyl hydrolase HVY57_RS06105 ENOG4105C30 Nad-dependent epimerase dehydratase HVY57_RS06110 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVY57_RS06115 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVY57_RS06120 ENOG4105ECJ Glycosyl Transferase HVY57_RS06125 ENOG4108NYJ Colanic acid HVY57_RS06130 ENOG4107RXY Glycosyl transferase HVY57_RS06135 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVY57_RS06140 ENOG41090RK glycosyl transferase HVY57_RS06145 ENOG4105D75 Capsular exopolysaccharide family HVY57_RS06150 ENOG4105KJF protein tyrosine phosphatase HVY57_RS06155 ENOG4105DAY polysaccharide export protein HVY57_RS06160 ENOG4105EE5 Membrane protein terC HVY57_RS06165 ENOG4105EQR Transposase IS116 IS110 IS902 HVY57_RS06170 ENOG4108GAE asmA family HVY57_RS06185 ENOG4105BZU Histidine kinase HVY57_RS06190 ENOG4105D03 DNA-3-methyladenine glycosylase II HVY57_RS06195 ENOG4105R8A Heat shock protein HVY57_RS06200 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVY57_RS06205 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HVY57_RS06210 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVY57_RS06215 ENOG4108M24 von Willebrand factor, type A HVY57_RS06250 ENOG4105EB3 Histidine kinase HVY57_RS06255 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY57_RS06260 ENOG4105KWI UPF0339 protein HVY57_RS06265 ENOG4105X54 addiction module antidote protein HVY57_RS06275 ENOG4105CFP Peptidase U32 HVY57_RS06285 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVY57_RS06290 ENOG4105IE8 Alpha-ketoglutarate permease HVY57_RS06295 ENOG4105CMG Carbohydrate kinase HVY57_RS06300 ENOG4105DEI Mannitol dehydrogenase HVY57_RS06320 ENOG4105EF1 ribulokinase HVY57_RS06325 ENOG4105IE8 Alpha-ketoglutarate permease HVY57_RS06330 ENOG4105EIE fructose-bisphosphate aldolase HVY57_RS06335 ENOG4105EAA nucleoside HVY57_RS06340 ENOG4108KD5 ADP-ribosylation crystallin J1 HVY57_RS06345 ENOG4108TFM Kinase, PfkB family HVY57_RS06350 ENOG4105FDP GntR family transcriptional regulator HVY57_RS06360 ENOG4105DWF phosphomethylpyrimidine kinase HVY57_RS06370 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVY57_RS06375 ENOG410662B Type-1 fimbrial protein HVY57_RS06380 ENOG4105CW0 outer membrane usher protein HVY57_RS06385 ENOG4108MQF Chaperone HVY57_RS06395 ENOG41067AK Protein of unknown function (DUF2574) HVY57_RS06400 ENOG4105D1F ATP-binding protein HVY57_RS06410 ENOG4108KDT Molybdate metabolism regulator HVY57_RS06415 ENOG4108KDT Molybdate metabolism regulator HVY57_RS06420 ENOG4108KDT Molybdate metabolism regulator HVY57_RS06425 ENOG4108KDT Molybdate metabolism regulator HVY57_RS06435 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVY57_RS06440 ENOG4105RD5 HVY57_RS06445 ENOG4105DEG Vwa containing coxe family protein HVY57_RS06450 ENOG410903U zinc ion binding HVY57_RS06455 ENOG4108YCW (LipO)protein HVY57_RS06460 ENOG4108W15 Protein of unknown function (DUF1456) HVY57_RS06465 ENOG4108NEV two component transcriptional regulator, LytTR family HVY57_RS06470 ENOG4108HRK Histidine kinase HVY57_RS06475 ENOG4108XDN Transcriptional regulator HVY57_RS06485 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVY57_RS06490 ENOG4108IJ8 ABC transporter HVY57_RS06495 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVY57_RS06500 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVY57_RS06505 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVY57_RS06510 ENOG4105CXG d-lactate dehydrogenase HVY57_RS06515 ENOG41061WM D-Alanyl-D-Alanine HVY57_RS06520 ENOG41069YE inner membrane protein yohC HVY57_RS06525 ENOG4105KHU inner membrane protein YohD HVY57_RS06530 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVY57_RS06540 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVY57_RS06550 ENOG41067MG lrgb family HVY57_RS06560 ENOG4107GZ4 SanA protein HVY57_RS06565 ENOG4105Y9N Membrane HVY57_RS06570 ENOG4105BZ8 glutamate synthase HVY57_RS06575 ENOG4107SJI Dehydrogenase HVY57_RS06580 ENOG4107SDZ Galactoside transport system permease protein mglC HVY57_RS06585 ENOG4105C2J ABC transporter HVY57_RS06590 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVY57_RS06595 ENOG41060NJ transcriptional regulator HVY57_RS06600 ENOG4105DHF Membrane HVY57_RS06615 ENOG4105D05 Receptor HVY57_RS06620 ENOG4108IQI permease HVY57_RS06625 ENOG4105DUM transcriptional regulator, lysR family HVY57_RS06630 ENOG4105HMI Membrane HVY57_RS06640 ENOG4105DD7 kinase (PfkB family HVY57_RS06645 ENOG4105D9N nucleoside HVY57_RS06655 ENOG4108Y4K DNA-binding transcriptional activator HVY57_RS06660 ENOG4105D9N nucleoside HVY57_RS06665 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVY57_RS06670 ENOG4105DD7 kinase (PfkB family HVY57_RS06675 ENOG4105DM4 PTS System HVY57_RS06680 ENOG4105DE4 1-phosphofructokinase HVY57_RS06685 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVY57_RS06690 ENOG4105S8Q sugar efflux transporter HVY57_RS06695 ENOG4105KRS Proteinase inhibitor HVY57_RS06705 ENOG4105DEI Mannitol dehydrogenase HVY57_RS06710 ENOG4105CKI cobalamin synthesis protein HVY57_RS06715 ENOG41076MN Phosphoesterase, PA-phosphatase related HVY57_RS06720 ENOG4107TT5 NLP P60 protein HVY57_RS06725 ENOG4105CXC rtn protein HVY57_RS06730 ENOG4105E43 Extracellular solute-binding protein, family 5 HVY57_RS06735 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVY57_RS06740 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVY57_RS06745 ENOG4108JQ5 ABC transporter HVY57_RS06750 ENOG4105HG6 HVY57_RS06755 ENOG4105C2C drug resistance transporter, Bcr CflA HVY57_RS06760 ENOG4105I08 Pseudouridine synthase HVY57_RS06765 ENOG4105CFI type iii restriction protein res subunit HVY57_RS06790 ENOG4105E68 Sulfatase HVY57_RS06805 ENOG410658X HVY57_RS06810 ENOG4105WH1 Two component transcriptional regulator luxr family HVY57_RS06815 ENOG4105KWW Biogenesis protein HVY57_RS06820 ENOG4107QX9 Thiol disulfide interChange protein HVY57_RS06825 ENOG4105DA4 cytochrome c-type biogenesis protein HVY57_RS06835 ENOG4105X3C heme exporter protein HVY57_RS06840 ENOG41060IM Heme exporter protein HVY57_RS06845 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVY57_RS06850 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HVY57_RS06855 ENOG4105CUW cytochrome C-TYPE protein HVY57_RS06860 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVY57_RS06865 ENOG4105GXZ Ferredoxin-type protein NapH HVY57_RS06870 ENOG4108BGM Quinol dehydrogenase periplasmic component HVY57_RS06880 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVY57_RS06885 ENOG4108ZNS ferredoxin-type protein NapF HVY57_RS06895 ENOG4105D8X mechanosensitive ion channel HVY57_RS06905 ENOG4105ZY9 UPF0379 protein ybiM HVY57_RS06910 ENOG4108IU3 tonb-dependent siderophore receptor HVY57_RS06920 ENOG4105KSC Transcriptional regulator, TraR DksA family HVY57_RS06925 ENOG4105VR4 UPF0379 protein ybiJ HVY57_RS06930 ENOG4105DG4 malate L-lactate dehydrogenase HVY57_RS06935 ENOG4108MTB glycosyl transferase family HVY57_RS06940 ENOG4105DVT helicase HVY57_RS06945 ENOG4105C1J atp-dependent rna helicase HVY57_RS06950 ENOG4107MVR Transcriptional regulator HVY57_RS06960 ENOG4105CJ1 ABC, transporter HVY57_RS06965 ENOG4107QWP ABC-2 type transporter HVY57_RS06970 ENOG4107QWP ABC-2 type transporter HVY57_RS06975 ENOG4105I9U inner membrane protein ybhQ HVY57_RS06980 ENOG4105X23 Endonuclease Exonuclease phosphatase HVY57_RS06985 ENOG4105DZQ phospholipase D Transphosphatidylase HVY57_RS06990 ENOG4107UXM Membrane HVY57_RS07005 ENOG410733J conserved inner membrane protein HVY57_RS07010 ENOG4105DIJ Phosphoethanolamine transferase HVY57_RS07015 ENOG4105HFZ Membrane HVY57_RS07020 ENOG4108ZAF Molybdopterin HVY57_RS07025 ENOG4105M00 molybdopterin converting factor, subunit 1 HVY57_RS07035 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY57_RS07045 ENOG4105CHW UPF0052 protein HVY57_RS07055 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY57_RS07060 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVY57_RS07075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVY57_RS07080 ENOG4108V1U phospholipid-binding protein HVY57_RS07085 ENOG4105NBR Pectinesterase HVY57_RS07095 ENOG4108QHK Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway HVY57_RS07100 ENOG4105HRS Antitermination protein HVY57_RS07110 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HVY57_RS07120 ENOG4108K4B hydrolase HVY57_RS07130 ENOG4105E0C molybdate abc transporter HVY57_RS07135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVY57_RS07145 ENOG4105F4R Transcriptional regulator mode HVY57_RS07150 ENOG4105DKW ABC transporter HVY57_RS07155 ENOG4105CMR udp-glucose 4-epimerase HVY57_RS07160 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVY57_RS07170 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVY57_RS07180 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY57_RS07185 ENOG4105JND homeobox protein HVY57_RS07190 ENOG4105PGM cation diffusion facilitator family transporter HVY57_RS07195 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY57_RS07245 ENOG4105UFD tol-pal system protein YbgF HVY57_RS07250 ENOG4105KCK Peptidoglycan-associated lipoprotein HVY57_RS07260 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVY57_RS07270 ENOG4105E02 MotA TolQ exbB proton channel HVY57_RS07275 ENOG4107YD3 Thioesterase HVY57_RS07280 ENOG4105KJB cyd operon protein YbgE HVY57_RS07290 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY57_RS07295 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY57_RS07300 ENOG4105C8I hydrolase, family 38 HVY57_RS07305 ENOG4105DM4 PTS System HVY57_RS07310 ENOG4105FDP GntR family transcriptional regulator HVY57_RS07315 ENOG4107WFU Glutamate mutase subunit sigma HVY57_RS07325 ENOG4105DJI Methylaspartate mutase, E subunit HVY57_RS07350 ENOG4107GFK fumarate HVY57_RS07355 ENOG4105ETT transcriptional Regulator, LysR family HVY57_RS07360 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVY57_RS07370 ENOG4105C7S Dehydrogenase HVY57_RS07375 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVY57_RS07380 ENOG4105E33 succinate dehydrogenase HVY57_RS07385 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY57_RS07390 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVY57_RS07395 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVY57_RS07400 ENOG4105BZN citrate synthase HVY57_RS07405 ENOG4106UBK fimbrial-like adhesin protein HVY57_RS07410 ENOG4106PG1 outer membrane usher protein HVY57_RS07415 ENOG4108TTM chaperone HVY57_RS07420 ENOG4108MY7 Fimbrial HVY57_RS07425 ENOG4108KK1 membrane protein AbrB duplication HVY57_RS07450 ENOG4107R7A Allophanate hydrolase subunit 2 HVY57_RS07455 ENOG4105P4J Allophanate hydrolase, subunit 1 HVY57_RS07460 ENOG4107QNR UPF0135 protein HVY57_RS07465 ENOG4105DUX Transporter HVY57_RS07470 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVY57_RS07475 ENOG4107SEY Conserved Protein HVY57_RS07480 ENOG4105XIQ Protein of unknown function (DUF2517) HVY57_RS07505 ENOG4105C08 Histidine kinase HVY57_RS07510 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVY57_RS07515 ENOG4105CXN decarboxylase HVY57_RS07520 ENOG4105D5Q Arginine ornithine antiporter HVY57_RS07525 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVY57_RS07530 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVY57_RS07535 ENOG4105EV9 Alpha Beta Hydrolase HVY57_RS07540 ENOG4105NNH LexA regulated protein HVY57_RS07545 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVY57_RS07555 ENOG41090R7 Ferric uptake HVY57_RS07560 ENOG4105GX6 (LipO)protein HVY57_RS07575 ENOG4105CI1 PTS System HVY57_RS07585 ENOG4105CE4 GlcNAc 6-P deacetylase HVY57_RS07590 ENOG4105E2R ROK family HVY57_RS07595 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVY57_RS07600 ENOG4105CAQ asparagine synthetase HVY57_RS07650 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY57_RS07660 ENOG4105C9A Phoh family HVY57_RS07670 ENOG4108JU5 Magnesium and cobalt efflux protein HVY57_RS07675 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVY57_RS07680 ENOG4107U91 Rhomboid family HVY57_RS07685 ENOG4107RP9 extracellular solute-binding protein, family 3 HVY57_RS07690 ENOG4105EAD ABC transporter HVY57_RS07695 ENOG4105DRP amino acid AbC transporter HVY57_RS07700 ENOG4105CDA abc transporter atp-binding protein HVY57_RS07720 ENOG4107PAI alpha helical protein HVY57_RS07735 ENOG4105DJF DNA polymerase III, delta' subunit HVY57_RS07745 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVY57_RS07755 ENOG4105CJN penicillin-binding protein HVY57_RS07760 ENOG4105CNI cell division protein FtsW HVY57_RS07765 ENOG4105K6T rare lipoprotein A HVY57_RS07770 ENOG4105DZ1 carboxypeptidase HVY57_RS07780 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HVY57_RS07810 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVY57_RS07815 ENOG4105CEE C4-dicarboxylate transporter HVY57_RS07820 ENOG4105KTS ribonuclease HVY57_RS07825 ENOG4105NXH GreA GreB family elongation factor HVY57_RS07830 ENOG4108U51 Universal stress protein HVY57_RS07835 ENOG4108JU3 Alkyl hydroperoxide reductase HVY57_RS07840 ENOG4105D3R alkyl hydroperoxide reductase HVY57_RS07850 ENOG4105DQS Transcriptional regulator HVY57_RS07855 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVY57_RS07860 ENOG4105GTN ParB Domain Protein Nuclease HVY57_RS07865 ENOG4105CHM Aminotransferase HVY57_RS07870 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVY57_RS07875 ENOG4105VCD cytoplasmic protein HVY57_RS07880 ENOG4105D22 carbon starvation protein HVY57_RS07885 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVY57_RS07890 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVY57_RS07895 ENOG4105WQI isochorismatase HVY57_RS07900 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVY57_RS07905 ENOG4105E4F Isochorismate synthase HVY57_RS07910 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVY57_RS07920 ENOG4105DQ5 transport system permease protein HVY57_RS07925 ENOG4105TVJ transport system, permease HVY57_RS07930 ENOG4105E0A ABC, transporter HVY57_RS07935 ENOG4108QY5 Ferric enterobactin transport protein HVY57_RS07940 ENOG4105C0W non-ribosomal peptide synthetase HVY57_RS07945 ENOG41085A6 mbth domain-containing protein HVY57_RS07950 ENOG4105E93 esterase HVY57_RS07955 ENOG4107RNH Outer membrane receptor FepA HVY57_RS07960 ENOG4108TSE Transferase HVY57_RS07965 ENOG4108IUS Transketolase HVY57_RS07970 ENOG4108HHA Transketolase HVY57_RS07975 ENOG4105DKT Transcriptional regulator HVY57_RS07980 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HVY57_RS07985 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY57_RS08000 ENOG4105CNN ABC, transporter HVY57_RS08015 ENOG4108SER Transposase HVY57_RS08025 ENOG4108SER Transposase HVY57_RS08040 ENOG4105WQ6 Membrane HVY57_RS08045 ENOG4105MSB protein, conserved in bacteria HVY57_RS08050 ENOG4108RCM Nitroreductase HVY57_RS08055 ENOG4105CUY Mechanosensitive ion channel HVY57_RS08060 ENOG4105C85 amino acid HVY57_RS08065 ENOG4108IJF Heavy metal efflux pump, CzcA HVY57_RS08070 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVY57_RS08075 ENOG410624V efflux system protein HVY57_RS08080 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVY57_RS08085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY57_RS08090 ENOG4105GR3 Histidine kinase HVY57_RS08095 ENOG410600T transposase HVY57_RS08130 ENOG4107QMP dna polymerase iii subunits gamma and tau HVY57_RS08140 ENOG4105WD1 Membrane HVY57_RS08145 ENOG4108URS primosomal replication protein n'' HVY57_RS08150 ENOG4106428 Protein of unknown function (DUF2496) HVY57_RS08155 ENOG4105EGS Mechanosensitive ion channel HVY57_RS08160 ENOG4107XI7 Tetr family transcriptional regulator HVY57_RS08165 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY57_RS08170 ENOG4105BZS acriflavin resistance protein HVY57_RS08175 ENOG4108UKR Biofilm formation regulator YbaJ HVY57_RS08185 ENOG4105GSJ Inner membrane protein ylaC HVY57_RS08190 ENOG41066DG (EAL) domain protein HVY57_RS08195 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVY57_RS08205 ENOG41080UX Methyltransferase HVY57_RS08210 ENOG4108MNP Glycoprotein polysaccharide metabolism HVY57_RS08215 ENOG4105C29 acyl-CoA thioesterase HVY57_RS08220 ENOG4105BZU Histidine kinase HVY57_RS08225 ENOG4108YZA Nitrogen regulatory protein pii HVY57_RS08230 ENOG4105BZ1 (ABC) transporter HVY57_RS08235 ENOG4105BZ1 (ABC) transporter HVY57_RS08240 ENOG4108XM1 transcriptional regulator AsnC family HVY57_RS08250 ENOG4108NFA extracellular solute-binding protein HVY57_RS08260 ENOG4108TGP Thioesterase superfamily protein HVY57_RS08265 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVY57_RS08270 ENOG4105EIN peptidylprolyl cis-trans isomerase HVY57_RS08275 ENOG4105K70 DNA-binding protein HVY57_RS08280 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVY57_RS08300 ENOG4105M85 Bola protein HVY57_RS08305 ENOG4105IEY (LipO)protein HVY57_RS08310 ENOG4105EYM Major Facilitator superfamily HVY57_RS08315 ENOG4105E2S oxidase) subunit II HVY57_RS08320 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVY57_RS08325 ENOG4105CCU oxidase (Subunit III) HVY57_RS08330 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVY57_RS08350 ENOG4107HP6 Transcriptional regulator HVY57_RS08355 ENOG4107V59 shikimate HVY57_RS08360 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVY57_RS08370 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVY57_RS08380 ENOG4105D2S major facilitator superfamily HVY57_RS08385 ENOG4107RDB Major Facilitator HVY57_RS08395 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVY57_RS08400 ENOG4107S0N DJ-1 family HVY57_RS08415 ENOG4105CTB Polyprenyl synthetase HVY57_RS08425 ENOG4105CPC Aldo Keto reductase HVY57_RS08430 ENOG4108ZAI phosphatidylglycerophosphatase a HVY57_RS08435 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVY57_RS08445 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVY57_RS08450 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVY57_RS08460 ENOG4108KIC (LipO)protein HVY57_RS08465 ENOG4105DRB nucleoside-specific channel-forming protein HVY57_RS08470 ENOG4105N1F Hnh endonuclease HVY57_RS08475 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY57_RS08480 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY57_RS08485 ENOG4105VIE preprotein translocase, subunit YajC HVY57_RS08505 ENOG4107R28 alpha amylase, catalytic region HVY57_RS08510 ENOG4105C85 amino acid HVY57_RS08515 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVY57_RS08520 ENOG4105BZU Histidine kinase HVY57_RS08530 ENOG4107RH8 nuclease SbcCD subunit D HVY57_RS08535 ENOG4105EYH Exonuclease HVY57_RS08540 ENOG4105DKQ ROK family HVY57_RS08555 ENOG4105HBA AroM protein HVY57_RS08560 ENOG4105SS3 HVY57_RS08575 ENOG4105II7 pyrroline-5-carboxylate reductase HVY57_RS08580 ENOG4105BZU Histidine kinase HVY57_RS08585 ENOG4105VIF phosphate starvation-inducible protein HVY57_RS08600 ENOG4105CPF Cell wall formation (By similarity) HVY57_RS08605 ENOG4105UNH Membrane HVY57_RS08610 ENOG4105FR5 inner membrane protein YaiY HVY57_RS08615 ENOG4107QS8 (LipO)protein HVY57_RS08620 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVY57_RS08625 ENOG4107R6D beta-lactam binding protein AmpH HVY57_RS08630 ENOG4108PNB DNA-binding transcriptional regulator HVY57_RS08635 ENOG4108NSE outer membrane autotransporter barrel HVY57_RS08640 ENOG4105D52 delta-aminolevulinic acid dehydratase HVY57_RS08645 ENOG4105E2B Taurine dioxygenase HVY57_RS08650 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVY57_RS08655 ENOG4108IY8 ABC, transporter HVY57_RS08660 ENOG4106FTQ Taurine ABC transporter, periplasmic HVY57_RS08675 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY57_RS08680 ENOG4105DXD 2-methylcitrate dehydratase HVY57_RS08685 ENOG4105BZN citrate synthase HVY57_RS08690 ENOG4105CR4 methylisocitrate lyase HVY57_RS08695 ENOG4108JU7 Transcriptional regulator HVY57_RS08700 ENOG4105TDT uncharacterized protein yahO HVY57_RS08705 ENOG4105E82 cytochrome subunit of dehydrogenase HVY57_RS08710 ENOG4105BZU Histidine kinase HVY57_RS08715 ENOG4105C6F GntR Family Transcriptional Regulator HVY57_RS08720 ENOG4105CPQ Dehydrogenase HVY57_RS08725 ENOG4108I5G Major Facilitator superfamily HVY57_RS08730 ENOG4105BZU Histidine kinase HVY57_RS08740 ENOG4105BZU Histidine kinase HVY57_RS08745 ENOG4108HF7 Gcn5-related n-acetyltransferase HVY57_RS08755 ENOG4107SET aldo keto reductase HVY57_RS08760 ENOG4105EQ2 LysR family Transcriptional regulator HVY57_RS08850 ENOG4105DFP Integrase HVY57_RS08880 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVY57_RS08895 ENOG4108YGG dna repair protein HVY57_RS08900 ENOG4105MFG Antirestriction protein HVY57_RS08905 ENOG4106H6R UPF0380 protein HVY57_RS08910 ENOG4105F4K antigen 43 HVY57_RS08955 ENOG4108KBJ Inner membrane protein YkgB HVY57_RS08960 ENOG41066GK UPF0379 protein ykgI HVY57_RS08965 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY57_RS08970 ENOG4108K01 transcriptional regulator HVY57_RS08975 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY57_RS08980 ENOG4107QR9 Iron-sulfur cluster binding protein HVY57_RS08985 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVY57_RS09025 ENOG4108P8R HVY57_RS09030 ENOG4108P8R HVY57_RS09065 ENOG4105FCK Membrane HVY57_RS09085 ENOG4105CIN aminoacyl-histidine dipeptidase HVY57_RS09090 ENOG4108S2Y peptide Chain Release factor HVY57_RS09100 ENOG4108HYG acetyltransferase HVY57_RS09120 ENOG4107QYX exodeoxyribonuclease v alpha HVY57_RS09125 ENOG4107QKA exodeoxyribonuclease V beta HVY57_RS09130 ENOG4107QXK peptidase HVY57_RS09135 ENOG4105DSY exodeoxyribonuclease V, gamma HVY57_RS09140 ENOG4105RVB Prepilin peptidase dependent protein c HVY57_RS09145 ENOG4105SEN Protein of unknown function (DUF2509) HVY57_RS09150 ENOG4105JCS prepilin peptidase dependent protein HVY57_RS09155 ENOG4105IPU prepilin peptidase dependent protein A HVY57_RS09170 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVY57_RS09185 ENOG4105EE5 Membrane protein terC HVY57_RS09190 ENOG4105SUV lipoprotein YgdR HVY57_RS09195 ENOG4105CPC Aldo Keto reductase HVY57_RS09220 ENOG41060NJ transcriptional regulator HVY57_RS09230 ENOG4105RQF LysR family Transcriptional regulator HVY57_RS09235 ENOG4105CHU acetyl-coa acetyltransferase HVY57_RS09240 ENOG4108MHD transport protein HVY57_RS09245 ENOG4105ISV protein with bipartite regulator domain HVY57_RS09250 ENOG4108TC1 Transcriptional regulator HVY57_RS09260 ENOG410802X bacteriophage n4 adsorption protein b HVY57_RS09265 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVY57_RS09270 ENOG4105QUW HVY57_RS09275 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVY57_RS09280 ENOG4105DZC cytosine deaminase HVY57_RS09290 ENOG4108K5P (LipO)protein HVY57_RS09295 ENOG4105MP9 class II Aldolase HVY57_RS09315 ENOG4107RSM transcriptional regulator HVY57_RS09320 ENOG4105H3G oxidoreductase HVY57_RS09325 ENOG4105KME endoribonuclease L-psp HVY57_RS09335 ENOG4105CWC Acetylornithine deacetylase HVY57_RS09340 ENOG4105CVK Glutamate decarboxylase HVY57_RS09345 ENOG4105CSV Glutaminase HVY57_RS09350 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVY57_RS09355 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVY57_RS09360 ENOG4105C7W Xanthine dehydrogenase HVY57_RS09365 ENOG4107XAN XdhC and CoxI family HVY57_RS09380 ENOG4105CRK lysyL-tRNA synthetase HVY57_RS09390 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVY57_RS09395 ENOG4105T95 Thiol disulfide interChange protein HVY57_RS09400 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY57_RS09405 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVY57_RS09410 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVY57_RS09415 ENOG4105Y75 tpr repeat protein HVY57_RS09425 ENOG4108UT2 hemolysin iii HVY57_RS09435 ENOG4105CS2 ec 3.2.1.21 HVY57_RS09465 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY57_RS09470 ENOG4105D0A hydroxylase HVY57_RS09475 ENOG4107RAQ aminopeptidase HVY57_RS09495 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVY57_RS09505 ENOG4108JQ1 Dehydrogenase HVY57_RS09520 ENOG4105MPN Membrane HVY57_RS09525 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVY57_RS09530 ENOG4105D64 Mechanosensitive ion channel HVY57_RS09535 ENOG4105D2N Aldolase HVY57_RS09550 ENOG4107Z1W Fructose transport system kinase HVY57_RS09555 ENOG4108R4K DNA-binding, transcriptional regulator HVY57_RS09560 ENOG4108Q8A Fructose-1,6-bisphosphatase HVY57_RS09565 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY57_RS09570 ENOG4105CTS PTS system mannitol-specific HVY57_RS09575 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVY57_RS09580 ENOG4105EPW hflc protein HVY57_RS09585 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY57_RS09590 ENOG4108K0D peptidase, M48 HVY57_RS09610 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVY57_RS09630 ENOG4107QNK )-transporter HVY57_RS09640 ENOG4105RWS endonuclease I HVY57_RS09645 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVY57_RS09650 ENOG4105D7Z glutathione synthase HVY57_RS09665 ENOG4105CZX twitching motility protein HVY57_RS09670 ENOG4105DFA alanine racemase domain protein HVY57_RS09675 ENOG4108VIA integral membrane protein HVY57_RS09685 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVY57_RS09690 ENOG4105CSA Coproporphyrinogen iii oxidase HVY57_RS09695 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY57_RS09700 ENOG41069H7 transport system small permease component HVY57_RS09705 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY57_RS09710 ENOG4106MH3 alpha helix chain HVY57_RS09715 ENOG4105HDK L-asparaginase HVY57_RS09720 ENOG4105K33 Periplasmic Protein HVY57_RS09725 ENOG41090ED Protein with unknown function (DUF469) HVY57_RS09735 ENOG4105CEN a g-specific adenine glycosylase HVY57_RS09750 ENOG4105EAA nucleoside HVY57_RS09755 ENOG4105CXN decarboxylase HVY57_RS09760 ENOG4108UQV Membrane HVY57_RS09770 ENOG4105F2I Transposase HVY57_RS09815 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY57_RS09855 ENOG4108QDQ Ubiquinol-cytochrome C chaperone HVY57_RS09860 ENOG4108KZE transcriptional regulator HVY57_RS09930 ENOG4107QHF type ii secretion system protein e HVY57_RS09935 ENOG4105D7Q type ii secretion system HVY57_RS09940 ENOG4108VAU general secretion pathway protein G HVY57_RS09950 ENOG4105X5Z General secretion pathway protein I HVY57_RS09970 ENOG4105U1E general secretion pathway protein M HVY57_RS09975 ENOG410600K aminopeptidase HVY57_RS10005 ENOG4106032 Glutathionylspermidine synthase HVY57_RS10015 ENOG4105CYM Glutathione S-transferase HVY57_RS10020 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVY57_RS10030 ENOG4108WGS hydrogenase 2-specific chaperone HVY57_RS10035 ENOG4108USZ hydrogenase HVY57_RS10040 ENOG4105DPX Hydrogenase, large subunit HVY57_RS10045 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVY57_RS10050 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY57_RS10055 ENOG4105E3S small subunit HVY57_RS10060 ENOG410900S Protein of unknown function (DUF2623) HVY57_RS10070 ENOG4105CPC Aldo Keto reductase HVY57_RS10080 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVY57_RS10085 ENOG4108ZZF transport protein (ExbD) HVY57_RS10090 ENOG4105CWK Biopolymer transport protein, ExbB HVY57_RS10095 ENOG4105C28 cystathionine HVY57_RS10100 ENOG4108K81 inner membrane protein YghB HVY57_RS10105 ENOG4105CF7 AraC family transcriptional regulator HVY57_RS10110 ENOG4108I6A alcohol dehydrogenase HVY57_RS10115 ENOG4105CV8 reductase HVY57_RS10120 ENOG4107QPK )-transporter HVY57_RS10130 ENOG4105CCT upf0313 protein HVY57_RS10135 ENOG4107YCY Transcriptional regulator HVY57_RS10140 ENOG4105DEI Mannitol dehydrogenase HVY57_RS10145 ENOG4105CPQ Dehydrogenase HVY57_RS10150 ENOG4105DG4 malate L-lactate dehydrogenase HVY57_RS10155 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY57_RS10165 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY57_RS10170 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVY57_RS10175 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVY57_RS10180 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY57_RS10185 ENOG4105H4F exported protein HVY57_RS10190 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY57_RS10195 ENOG4105DHQ Histidine kinase HVY57_RS10200 ENOG4105NF4 modulator of drug activity HVY57_RS10205 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVY57_RS10210 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY57_RS10215 ENOG4105IPS esterase HVY57_RS10220 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVY57_RS10225 ENOG4108SX3 cytoplasmic protein HVY57_RS10230 ENOG41087AY ADP-Ribose pyrophosphatase HVY57_RS10235 ENOG4105DFG type I secretion outer membrane protein HVY57_RS10245 ENOG4106032 Glutathionylspermidine synthase HVY57_RS10250 ENOG4108MR7 Arylsulfotransferase HVY57_RS10255 ENOG4108N92 Thiol disulfide Interchange Protein HVY57_RS10265 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVY57_RS10280 ENOG4105H8W Fimbrial protein HVY57_RS10290 ENOG4108TTM chaperone HVY57_RS10315 ENOG4105W0Z cytoplasmic protein HVY57_RS10325 ENOG4105PV3 Inner membrane protein yqiJ HVY57_RS10330 ENOG4107S78 Band 7 protein HVY57_RS10365 ENOG4105I7R Adenylate cyclase HVY57_RS10370 ENOG4106MWK domain protein HVY57_RS10385 ENOG4107ZVW dihydroneopterin aldolase HVY57_RS10395 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVY57_RS10405 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVY57_RS10410 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY57_RS10430 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVY57_RS10470 ENOG41080XV Thioredoxin HVY57_RS10480 ENOG4105Q26 Siderophore-interacting protein HVY57_RS10485 ENOG4105NTW Transcriptional regulator HVY57_RS10490 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVY57_RS10500 ENOG4105CBP Major Facilitator HVY57_RS10510 ENOG4105C6F GntR Family Transcriptional Regulator HVY57_RS10515 ENOG4105DEI Mannitol dehydrogenase HVY57_RS10525 ENOG4105Y4Z Outer Membrane Lipoprotein HVY57_RS10540 ENOG4105KT7 mgtC SapB transporter HVY57_RS10545 ENOG4105XXV Acid-resistance protein HVY57_RS10550 ENOG41060V2 Acid-resistance protein HVY57_RS10555 ENOG4108YK4 Acid-resistance membrane protein HVY57_RS10560 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVY57_RS10565 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY57_RS10570 ENOG4105BZS acriflavin resistance protein HVY57_RS10580 ENOG4108NKV transcriptional regulator HVY57_RS10585 ENOG4105D6F Phosphatase HVY57_RS10590 ENOG4108V8F Transcriptional regulator, MarR family HVY57_RS10615 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HVY57_RS10620 ENOG4105FUY alpha subunit HVY57_RS10625 ENOG4107Z7P Ferredoxin HVY57_RS10630 ENOG4105CSP Major Facilitator Superfamily HVY57_RS10635 ENOG4105F2I Transposase HVY57_RS10640 ENOG4105CSP Major Facilitator Superfamily HVY57_RS10645 ENOG4106D80 Uncharacterized protein YhaL HVY57_RS10660 ENOG4105C7B Threonine dehydratase HVY57_RS10665 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVY57_RS10670 ENOG4105CIZ coA-substrate-specific enzyme activase HVY57_RS10680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY57_RS10685 ENOG4105C8Q Methyl-accepting chemotaxis HVY57_RS10695 ENOG4108IA2 Sodium pantothenate symporter HVY57_RS10715 ENOG4108V8F Transcriptional regulator, MarR family HVY57_RS10720 ENOG4105ERH Fumarylacetoacetate hydrolase HVY57_RS10725 ENOG4105C26 Dehydrogenase HVY57_RS10730 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVY57_RS10760 ENOG4105EFA 4-hydroxyphenylacetate HVY57_RS10765 ENOG4107UWN reductase HVY57_RS10770 ENOG4105D22 carbon starvation protein HVY57_RS10775 ENOG4105VCD cytoplasmic protein HVY57_RS10780 ENOG4105CKI cobalamin synthesis protein HVY57_RS10790 ENOG4106DIZ Domain of unknown function (DUF1127) HVY57_RS10795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY57_RS10805 ENOG41083G8 Multidrug resistance protein MdtM HVY57_RS10810 ENOG4106BRA Membrane HVY57_RS10835 ENOG4105F2I Transposase HVY57_RS10870 ENOG4105DQ4 alcohol dehydrogenase HVY57_RS10875 ENOG4105D7A ATP-binding protein HVY57_RS10880 ENOG4107S21 permease HVY57_RS10900 ENOG4107R7Y intracellular protease Pfpi family HVY57_RS10915 ENOG4108YYD acetyltransferase HVY57_RS10935 ENOG4105DEN Luciferase family HVY57_RS10940 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVY57_RS10985 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HVY57_RS11005 ENOG4108K70 Transcriptional regulator HVY57_RS11010 ENOG4105CIC tryptophan-specific transport protein HVY57_RS11015 ENOG4105C1J atp-dependent rna helicase HVY57_RS11055 ENOG4105CHV Transcription elongation factor NusA HVY57_RS11075 ENOG4105DIJ Phosphoethanolamine transferase HVY57_RS11085 ENOG4105NTZ Preprotein translocase subunit SecG HVY57_RS11095 ENOG4105EEI dihydropteroate synthase HVY57_RS11100 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVY57_RS11110 ENOG4105HBR Rna-binding protein HVY57_RS11115 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVY57_RS11120 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVY57_RS11130 ENOG4105QYV Membrane HVY57_RS11145 ENOG4105EAH synthase HVY57_RS11150 ENOG4105HVQ Regulatory factor of maltose metabolism HVY57_RS11160 ENOG4105VFK BolA family HVY57_RS11165 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVY57_RS11170 ENOG4105E3I toluene tolerance HVY57_RS11175 ENOG4107PE3 Mammalian cell entry related domain protein HVY57_RS11180 ENOG4105CY3 ABC transporter, permease HVY57_RS11185 ENOG4105DHJ ABC, transporter HVY57_RS11190 ENOG4105FEU K -dependent Na -Ca exchanger HVY57_RS11195 ENOG4105C2X Arabinose 5-phosphate isomerase HVY57_RS11205 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVY57_RS11210 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVY57_RS11215 ENOG4108IUZ ABC transporter HVY57_RS11220 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY57_RS11225 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVY57_RS11230 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVY57_RS11240 ENOG41080Z8 PHOSPHOCARRIER protein HVY57_RS11245 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVY57_RS11255 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVY57_RS11260 ENOG4105BZU Histidine kinase HVY57_RS11265 ENOG4105N5T Radical SAM Protein HVY57_RS11270 ENOG4105CBC glutamate synthase HVY57_RS11275 ENOG4105BZ8 glutamate synthase HVY57_RS11280 ENOG4105DFS Conserved Protein HVY57_RS11285 ENOG4108R66 Conserved Protein HVY57_RS11315 ENOG4105KB2 stringent starvation protein b HVY57_RS11320 ENOG4107MKT Stringent starvation protein a HVY57_RS11335 ENOG4105D6Z AFG1 family ATPase HVY57_RS11340 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVY57_RS11345 ENOG4105C0H protease HVY57_RS11350 ENOG4105C0H protease HVY57_RS11360 ENOG4107GFK fumarate HVY57_RS11365 ENOG4106DSS Tartrate dehydratase subunit alpha HVY57_RS11370 ENOG4105C8P )-transporter HVY57_RS11380 ENOG4105G3Z GntR family transcriptional regulator HVY57_RS11395 ENOG4105RID UPF0379 protein yhcN HVY57_RS11400 ENOG4105UNR (Barnase) inhibitor HVY57_RS11415 ENOG4105ZQC membrane protein AaeX HVY57_RS11420 ENOG4105CR8 Transcriptional regulator HVY57_RS11425 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVY57_RS11430 ENOG4105QD6 exported protein HVY57_RS11435 ENOG4105C03 ribonuclease HVY57_RS11445 ENOG4105VQ7 Rod shape-determining protein MreD HVY57_RS11450 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVY57_RS11465 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVY57_RS11470 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVY57_RS11485 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVY57_RS11490 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVY57_RS11495 ENOG4105RG0 Membrane HVY57_RS11500 ENOG4108IA2 Sodium pantothenate symporter HVY57_RS11510 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY57_RS11520 ENOG4105CEC DNA methylase N-4 N-6 HVY57_RS11525 ENOG41061ME transport protein HVY57_RS11550 ENOG4105BZS acriflavin resistance protein HVY57_RS11555 ENOG4105XCM membrane LIPOPROTEIN HVY57_RS11565 ENOG4105EZ7 amino acid ABC transporter HVY57_RS11570 ENOG4105DRP amino acid AbC transporter HVY57_RS11575 ENOG4105CDA abc transporter atp-binding protein HVY57_RS11615 ENOG4108Z0R Transferase HVY57_RS11620 ENOG4105SG3 Protein of unknown function (DUF1488) HVY57_RS11635 ENOG4108WI1 Dna topoisomerase HVY57_RS11645 ENOG4105C79 DNA protecting protein DprA HVY57_RS11665 ENOG4105C1A potassium transporter peripheral membrane HVY57_RS11675 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVY57_RS11680 ENOG4105W1Y Transcriptional regulator HVY57_RS11685 ENOG4105VTS DnaJ-like, subfamily C HVY57_RS11715 ENOG41067V7 50S ribosomal protein L36 HVY57_RS11720 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVY57_RS11765 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVY57_RS11810 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVY57_RS11835 ENOG4108UQY Iron-storage protein HVY57_RS11840 ENOG4105W53 bacterioferritin-associated ferredoxin HVY57_RS11880 ENOG4105WWK YheO domain protein HVY57_RS11885 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY57_RS11895 ENOG4108YZY peptidylprolyl cis-trans isomerase HVY57_RS11900 ENOG4105VKU nucleicacid-binding protein HVY57_RS11915 ENOG4105C5H ABC transporter HVY57_RS11920 ENOG4105DNZ Alpha Beta Hydrolase HVY57_RS11930 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVY57_RS11935 ENOG4108UKZ OsmC family HVY57_RS11945 ENOG410613R integral membrane protein, YccS YhfK family HVY57_RS11950 ENOG4105C8Y Acetylornithine aminotransferase HVY57_RS11955 ENOG4105DDQ anthranilate synthase HVY57_RS11960 ENOG4105MZU cell filamentation protein HVY57_RS11970 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY57_RS11975 ENOG4107QZF nitrite reductase NADPH large subunit HVY57_RS11980 ENOG4105WZK nitrite reductase NADPH small subunit HVY57_RS11985 ENOG4107V9H nitrite transporter HVY57_RS11995 ENOG4105VYH HVY57_RS12000 ENOG4106PKC pyridoxal phosphate binding HVY57_RS12005 ENOG4106M0N transport system permease protein HVY57_RS12010 ENOG4105MUZ Protein of unknown function DUF2620 HVY57_RS12015 ENOG41080QX K07048 phosphotriesterase-related protein HVY57_RS12020 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVY57_RS12025 ENOG4108626 Racemase HVY57_RS12030 ENOG4105RMW regulation of transcription, DNA-dependent HVY57_RS12035 ENOG4108M21 HVY57_RS12040 ENOG4105C31 Tryptophanyl-tRNA synthetase HVY57_RS12045 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVY57_RS12050 ENOG4105DJV ribulose-phosphate 3-epimerase HVY57_RS12055 ENOG4105DFE Dna adenine methylase HVY57_RS12060 ENOG4105EGB membrane protein DamX HVY57_RS12075 ENOG4105E4G Type IV pilus HVY57_RS12080 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVY57_RS12085 ENOG4105XPX DNA utilization protein HofO HVY57_RS12090 ENOG41065NF Fimbrial assembly family protein HVY57_RS12095 ENOG4108U1Q Pilus assembly protein HVY57_RS12100 ENOG4108JQC penicillin-binding protein 1A HVY57_RS12105 ENOG4107RK2 ADP-ribose diphosphatase NudE HVY57_RS12110 ENOG4105DQY intracellular growth attenuator HVY57_RS12115 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVY57_RS12120 ENOG4105VEJ Heat shock protein HVY57_RS12130 ENOG4108MAJ Membrane HVY57_RS12155 ENOG4105E0F Histidine kinase HVY57_RS12165 ENOG4108RRZ Transcription elongation factor GreB HVY57_RS12170 ENOG4105BZM domain protein HVY57_RS12175 ENOG4105XFK Ferrous iron transport protein A HVY57_RS12180 ENOG4105CE1 Ferrous iron transport protein b HVY57_RS12190 ENOG4105DNE Transposase HVY57_RS12200 ENOG4105MJ2 Competence protein HVY57_RS12210 ENOG4105C6Z Gluconate HVY57_RS12215 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVY57_RS12220 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY57_RS12230 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HVY57_RS12235 ENOG4105E0Y RtcB Protein HVY57_RS12245 ENOG4105E98 transcriptional regulator DeoR family HVY57_RS12260 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVY57_RS12285 ENOG4105CVA phosphate HVY57_RS12290 ENOG4105MHR Fimbrial protein HVY57_RS12295 ENOG4106PH7 chaperone HVY57_RS12305 ENOG4108WDE Fimbrial protein HVY57_RS12310 ENOG4105CW0 outer membrane usher protein HVY57_RS12315 ENOG4108NAE Fimbrial chaperone protein HVY57_RS12325 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY57_RS12350 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY57_RS12355 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVY57_RS12360 ENOG4105C6Z Gluconate HVY57_RS12365 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVY57_RS12370 ENOG4105DIQ Transcriptional regulator HVY57_RS12375 ENOG4105C2I pirin domain protein HVY57_RS12380 ENOG4105D9R oxidoreductase HVY57_RS12385 ENOG4105WCN acetyltransferase HVY57_RS12390 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVY57_RS12395 ENOG4105WC8 Conserved Protein HVY57_RS12400 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVY57_RS12410 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVY57_RS12415 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVY57_RS12420 ENOG4105BZ7 extracellular solute-binding protein family 1 HVY57_RS12425 ENOG4108IV0 ABC, transporter HVY57_RS12430 ENOG4105C0Z ABC transporter HVY57_RS12435 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVY57_RS12440 ENOG4105C32 Amino acid ABC transporter (Permease) HVY57_RS12445 ENOG4105CP9 extracellular ligand-binding receptor HVY57_RS12450 ENOG4105U59 -acetyltransferase HVY57_RS12455 ENOG4105CP9 extracellular ligand-binding receptor HVY57_RS12460 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY57_RS12465 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVY57_RS12470 ENOG4105CAK Cell division ATP-binding protein ftsE HVY57_RS12475 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVY57_RS12480 ENOG4106H78 methyltransferase HVY57_RS12485 ENOG4105MG3 Membrane HVY57_RS12495 ENOG4107FS9 Membrane HVY57_RS12510 ENOG4105EX9 Membrane HVY57_RS12515 ENOG4108W1V Lipoprotein HVY57_RS12520 ENOG4105F9N Major Facilitator Superfamily HVY57_RS12525 ENOG4105DSF transport protein HVY57_RS12555 ENOG4105E9Q Acyl-transferase HVY57_RS12585 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HVY57_RS12610 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY57_RS12620 ENOG4105C2D reductase HVY57_RS12625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY57_RS12630 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVY57_RS12640 ENOG4105CMI transporter HVY57_RS12645 ENOG4105CJ1 ABC, transporter HVY57_RS12650 ENOG4105D0S secretion protein (HlyD HVY57_RS12655 ENOG4107UNS conserved inner membrane protein HVY57_RS12680 ENOG4105CBX hi0933 family HVY57_RS12685 ENOG4105CJ3 phosphate transporter HVY57_RS12700 ENOG4105DUX Transporter HVY57_RS12715 ENOG4105F38 ABC transporter, permease HVY57_RS12730 ENOG4105E2R ROK family HVY57_RS12740 ENOG4105DGW oligopeptidase A HVY57_RS12745 ENOG4105D6S protein involved in catabolism of external DNA HVY57_RS12750 ENOG4105DC8 reductase HVY57_RS12760 ENOG4105KBH arsR family transcriptional regulator HVY57_RS12765 ENOG4107R5R arsenical pump membrane protein HVY57_RS12770 ENOG4105K89 arsenate reductase HVY57_RS12790 ENOG4106S2D Transcriptional regulator HVY57_RS12800 ENOG4107H3J ribonuclease HVY57_RS12805 ENOG4105CSH Transporter HVY57_RS12810 ENOG41066T0 asmA family HVY57_RS12815 ENOG4105CMB EAL domain-containing protein HVY57_RS12820 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVY57_RS12870 ENOG4105CS0 peptidase HVY57_RS12880 ENOG4105BZU Histidine kinase HVY57_RS12885 ENOG4105EJG cellulose synthase HVY57_RS12890 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVY57_RS12895 ENOG4107EEX Cellulose synthase regulator protein HVY57_RS12900 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY57_RS12910 ENOG410661M cytoplasmic protein HVY57_RS12915 ENOG4105U74 cellulose biosynthesis protein BcsE HVY57_RS12920 ENOG4105WQA Cellulose biosynthesis protein BcsF HVY57_RS12925 ENOG4105D1V cellulose synthase operon protein YhjU HVY57_RS12950 ENOG4105C28 cystathionine HVY57_RS12955 ENOG4105C44 Serine transporter HVY57_RS12965 ENOG4108JQ7 (ABC) transporter HVY57_RS12970 ENOG4105C3U ABC transporter HVY57_RS12975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY57_RS12980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY57_RS12985 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY57_RS13000 ENOG4105DIJ Phosphoethanolamine transferase HVY57_RS13005 ENOG4105FCD Major Facilitator HVY57_RS13010 ENOG4105EAX Putative lipase HVY57_RS13015 ENOG4108R3E Dna-3-methyladenine glycosylase i HVY57_RS13020 ENOG4105HNP -acetyltransferase HVY57_RS13025 ENOG4107QY8 reductase HVY57_RS13030 ENOG4108ZG0 Ompa motb domain protein HVY57_RS13035 ENOG4108M60 Transcriptional regulator HVY57_RS13045 ENOG4105D7K pfkb domain protein HVY57_RS13060 ENOG4106JH6 (LipO)protein HVY57_RS13065 ENOG4105D2S major facilitator superfamily HVY57_RS13070 ENOG4105MVF Transcriptional regulator HVY57_RS13100 ENOG4105MEV Acyl-transferase HVY57_RS13105 ENOG410688U Inner membrane protein yiaB HVY57_RS13110 ENOG4105CMG Carbohydrate kinase HVY57_RS13120 ENOG4105T16 Transcriptional regulator (AraC family) HVY57_RS13125 ENOG4108UR8 BAX protein HVY57_RS13130 ENOG4107T9C Alpha amylase catalytic region HVY57_RS13135 ENOG4105JKW Valine--pyruvate aminotransferase HVY57_RS13140 ENOG4108XIB electron transport protein ysaA HVY57_RS13145 ENOG4105J4Q Transcriptional regulator HVY57_RS13155 ENOG4108R66 Conserved Protein HVY57_RS13160 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVY57_RS13165 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY57_RS13170 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY57_RS13175 ENOG4105CMG Carbohydrate kinase HVY57_RS13180 ENOG4105H6Q decarboxylase HVY57_RS13185 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVY57_RS13190 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY57_RS13195 ENOG4105C26 Dehydrogenase HVY57_RS13200 ENOG4105C0A alcohol dehydrogenase HVY57_RS13205 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVY57_RS13215 ENOG4108U78 Glutathione S-transferase HVY57_RS13220 ENOG4105EFX secretion protein, HlyD family HVY57_RS13225 ENOG4105FP6 Protein of unknown function (DUF3302) HVY57_RS13230 ENOG4105CTS PTS system mannitol-specific HVY57_RS13240 ENOG4105E61 Mannitol repressor protein HVY57_RS13250 ENOG4108YYI Protein of unknown function (DUF2810) HVY57_RS13255 ENOG4108WY4 inner membrane lipoprotein HVY57_RS13260 ENOG4105EUR Domain-Containing protein HVY57_RS13265 ENOG4105DAA L-lactate HVY57_RS13270 ENOG41073TP transcriptional regulator HVY57_RS13280 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVY57_RS13285 ENOG4105D7W serine acetyltransferase HVY57_RS13300 ENOG4105VW4 glutaredoxin 3 HVY57_RS13305 ENOG4107YZP Rhodanese domain protein HVY57_RS13315 ENOG41063SB peptidase HVY57_RS13320 ENOG4105PXI polysaccharide deacetylase HVY57_RS13325 ENOG4105K64 Glycosyl transferase, family 2 HVY57_RS13330 ENOG4105D4P Coproporphyrinogen iii oxidase HVY57_RS13335 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVY57_RS13350 ENOG4105C2M dna polymerase I HVY57_RS13355 ENOG4106HNH Acyl-transferase HVY57_RS13365 ENOG4108Z33 Thiol disulfide Interchange Protein HVY57_RS13370 ENOG4105E27 serine threonine protein kinase HVY57_RS13375 ENOG4105PC1 Conserved Protein HVY57_RS13380 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVY57_RS13385 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVY57_RS13415 ENOG4108RR8 protoporphyrinogen oxidase HVY57_RS13420 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY57_RS13425 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVY57_RS13445 ENOG4108MR7 Arylsulfotransferase HVY57_RS13450 ENOG4108EX3 reductase HVY57_RS13455 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY57_RS13460 ENOG4105MDZ Transcriptional activator rfaH HVY57_RS13470 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVY57_RS13475 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVY57_RS13480 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVY57_RS13490 ENOG4105JC1 sterol-binding domain protein HVY57_RS13500 ENOG4105CGY Dna recombination protein HVY57_RS13505 ENOG4105J4Q Transcriptional regulator HVY57_RS13510 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVY57_RS13515 ENOG4108RTU Aldolase HVY57_RS13520 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVY57_RS13535 ENOG4108I5U Uridine phosphorylase HVY57_RS13540 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVY57_RS13565 ENOG4105F04 LysR family Transcriptional regulator HVY57_RS13580 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HVY57_RS13585 ENOG4105C7F AcnD-accessory protein PrpF HVY57_RS13590 ENOG4107QM5 aconitate hydratase HVY57_RS13595 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVY57_RS13600 ENOG4107QIJ Aconitate hydratase 2 HVY57_RS13615 ENOG4105DZ2 Transcriptional regulator HVY57_RS13620 ENOG4105EMK carboxylate amino acid amine transporter HVY57_RS13625 ENOG4105DQF Hydrolase HVY57_RS13630 ENOG4108EUD Lysophospholipase HVY57_RS13635 ENOG410829K Lysine exporter protein (Lyse ygga) HVY57_RS13645 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVY57_RS13650 ENOG4105C9U ATP-dependent DNA helicase RecQ HVY57_RS13655 ENOG4105HDD phospholipase HVY57_RS13660 ENOG4108VUY thioesterase Superfamily protein HVY57_RS13665 ENOG4105FR1 rard protein HVY57_RS13675 ENOG4107QUT magnesium and cobalt transport protein CorA HVY57_RS13680 ENOG4108T58 Mg2 transport protein CorA HVY57_RS13685 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVY57_RS13690 ENOG4105C4R Atp-dependent dna helicase HVY57_RS13695 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVY57_RS13705 ENOG4105CT0 Protein of unknown function, DUF484 HVY57_RS13715 ENOG4105S7Z (LipO)protein HVY57_RS13735 ENOG4107T0K Adenylate cyclase HVY57_RS13745 ENOG41076E6 Uroporphyrinogen-III Synthase HVY57_RS13750 ENOG4105ECF c-methyltransferase HVY57_RS13755 ENOG410601J HemY protein HVY57_RS13780 ENOG4105C4X radical SAM domain protein HVY57_RS13805 ENOG4105C85 amino acid HVY57_RS13825 ENOG4105EGZ biosynthesis protein HVY57_RS13830 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVY57_RS13835 ENOG4108WJ1 acetyltransferase HVY57_RS13840 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY57_RS13845 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY57_RS13850 ENOG4107QQG Dehydrogenase HVY57_RS13855 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVY57_RS13860 ENOG4105SFE lipopolysaccharide biosynthesis protein HVY57_RS13865 ENOG4105ESV Glycosyl transferase, family 4 HVY57_RS13870 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVY57_RS13895 ENOG4105C4R Atp-dependent dna helicase HVY57_RS13900 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVY57_RS13910 ENOG4105EMY transcriptional regulator HVY57_RS13915 ENOG4105C7B Threonine dehydratase HVY57_RS13925 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVY57_RS13930 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVY57_RS13950 ENOG4105C0P Mg chelatase subunit ChlI HVY57_RS13955 ENOG4108WFC UPF0438 protein yifE HVY57_RS13995 ENOG4107EJG GntR family transcriptional regulator HVY57_RS14000 ENOG4105ETE Transcriptional regulator (LacI family HVY57_RS14005 ENOG4108RVA ribokinase HVY57_RS14010 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY57_RS14015 ENOG4105CNN ABC, transporter HVY57_RS14020 ENOG4105C2J ABC transporter HVY57_RS14050 ENOG4108VVK transcriptional Regulator, AsnC HVY57_RS14055 ENOG4105QTB Flavodoxin HVY57_RS14070 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVY57_RS14125 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVY57_RS14130 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVY57_RS14135 ENOG4105C8U phosphate abc transporter HVY57_RS14140 ENOG4105E2Z phosphate ABC transporter (Permease HVY57_RS14145 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVY57_RS14150 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVY57_RS14155 ENOG4105CID antiterminator HVY57_RS14160 ENOG4105C5Y PTS System HVY57_RS14165 ENOG4105CS2 ec 3.2.1.21 HVY57_RS14175 ENOG4105DYC esterase HVY57_RS14180 ENOG4107VKM 6-phosphogluconolactonase HVY57_RS14185 ENOG4106611 bacteriocin immunity HVY57_RS14195 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVY57_RS14200 ENOG4105C7N Xanthine uracil vitamin C permease HVY57_RS14210 ENOG4108YYH Nadph-dependent fmn reductase HVY57_RS14215 ENOG4105E8Q phosphopantetheinyl transferase HVY57_RS14230 ENOG4108P6C Tryptophan transporter of low affinity HVY57_RS14265 ENOG4105VG0 50S ribosomal protein l34 HVY57_RS14280 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVY57_RS14290 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY57_RS14295 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVY57_RS14300 ENOG410667J hydrolase HVY57_RS14305 ENOG410657R replicase EC 2.7 HVY57_RS14310 ENOG4105EMF GntR family transcriptional regulator HVY57_RS14315 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVY57_RS14320 ENOG4108RTU Aldolase HVY57_RS14330 ENOG4105DJB Major Facilitator Superfamily HVY57_RS14340 ENOG4105D99 atp gtp-binding protein HVY57_RS14345 ENOG4105R2A (LipO)protein HVY57_RS14355 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HVY57_RS14360 ENOG4105D0C transport protein HVY57_RS14365 ENOG4105FDP GntR family transcriptional regulator HVY57_RS14370 ENOG4105CI1 PTS System HVY57_RS14375 ENOG4105F8D glycoside hydrolase family 4 HVY57_RS14380 ENOG4108AHD Transcriptional regulator HVY57_RS14385 ENOG4107RUZ Sss sodium solute transporter superfamily HVY57_RS14390 ENOG4105CBG Sulfatase HVY57_RS14395 ENOG4106DRA Inner membrane protein YidI HVY57_RS14400 ENOG4105VG5 Membrane HVY57_RS14405 ENOG4105JP4 Inner membrane protein yidG HVY57_RS14410 ENOG4105J13 transcriptional regulator HVY57_RS14415 ENOG4105E5M Multidrug resistance protein D HVY57_RS14430 ENOG4105C7K acetolactate synthase HVY57_RS14435 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVY57_RS14440 ENOG4108KX4 response regulator HVY57_RS14445 ENOG4105BZU Histidine kinase HVY57_RS14450 ENOG4105CXY transporter HVY57_RS14455 ENOG4105CXY transporter HVY57_RS14465 ENOG4108SAJ Protein of unknown function (DUF1198) HVY57_RS14475 ENOG4105VCP PTS System HVY57_RS14480 ENOG4105CS2 ec 3.2.1.21 HVY57_RS14485 ENOG4105CK1 PTS System HVY57_RS14495 ENOG4105ETE Transcriptional regulator (LacI family HVY57_RS14500 ENOG4105T8A Uncharacterized protein YicS HVY57_RS14505 ENOG4108UZ3 Transporter HVY57_RS14555 ENOG4105ZTC transcriptional activator, Ogr delta HVY57_RS14565 ENOG4105ESI atpase involved in dna repair HVY57_RS14570 ENOG4105DFP Integrase HVY57_RS14580 ENOG4105CT4 transporter HVY57_RS14585 ENOG4105CJQ hydrolase, family 31 HVY57_RS14590 ENOG4105JV1 AsmA family HVY57_RS14595 ENOG4105C2W permease HVY57_RS14600 ENOG4105D6U Sodium Glutamate Symporter HVY57_RS14610 ENOG4105CB5 ATP-dependent DNA helicase recG HVY57_RS14615 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVY57_RS14620 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY57_RS14630 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVY57_RS14640 ENOG4105EN6 Membrane HVY57_RS14645 ENOG4105DSJ YicC domain protein HVY57_RS14660 ENOG4107RRE RNA-directed DNA polymerase HVY57_RS14670 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVY57_RS14675 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVY57_RS14685 ENOG4105KDC 50s ribosomal protein l28 HVY57_RS14705 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVY57_RS14710 ENOG4105DKP glycosyl transferase, family 9 HVY57_RS14715 ENOG4107RJ7 Glycosyl transferase (Group 1 HVY57_RS14720 ENOG4107543 (lipo)polysaccharide HVY57_RS14725 ENOG410650X lipopolysaccharide core region biosynthetic process HVY57_RS14730 ENOG4107XU6 Glycosyl transferase (Group 1 HVY57_RS14735 ENOG4106AH0 Glycosyl Transferase HVY57_RS14740 ENOG4105X1N Glycosyl transferase family 8 HVY57_RS14745 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVY57_RS14750 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVY57_RS14755 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HVY57_RS14760 ENOG4108FRV O-antigen ligase HVY57_RS14765 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVY57_RS14770 ENOG4105XA0 heptosyltransferase ii HVY57_RS14780 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVY57_RS14790 ENOG4106FIY HVY57_RS14795 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY57_RS14800 ENOG4105CUX Signal transduction histidine kinase HVY57_RS14805 ENOG4105C5F glutamine synthetase HVY57_RS14810 ENOG4105CI3 gtp-binding protein typa HVY57_RS14815 ENOG4108KP7 hydrolase HVY57_RS14825 ENOG4105CSA Coproporphyrinogen iii oxidase HVY57_RS14845 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVY57_RS14860 ENOG4105SUU thioesterase domain HVY57_RS14890 ENOG4108MG3 formate dehydrogenase HVY57_RS14895 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY57_RS14910 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HVY57_RS14920 ENOG4106C3V frv operon regulatory protein HVY57_RS14925 ENOG4105CN9 Peptidase m42 family protein HVY57_RS14930 ENOG4105DM4 PTS System HVY57_RS14935 ENOG41064BA PTS system, fructose-specific, IIA component HVY57_RS14945 ENOG4105C0A alcohol dehydrogenase HVY57_RS14980 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY57_RS14985 ENOG4108RPX mosc domain containing protein HVY57_RS14990 ENOG4105E0F Histidine kinase HVY57_RS14995 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY57_RS15000 ENOG4105FMW periplasmic HVY57_RS15015 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVY57_RS15030 ENOG4105EBK exported protein HVY57_RS15035 ENOG4108VTS Membrane HVY57_RS15040 ENOG41065TG regulatoR HVY57_RS15050 ENOG4105DP0 ferredoxin-NADP reductase HVY57_RS15055 ENOG4105CBT Fructose-1,6-bisphosphatase HVY57_RS15065 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY57_RS15080 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVY57_RS15095 ENOG41063M6 Cell Division Protein HVY57_RS15100 ENOG4105ETE Transcriptional regulator (LacI family HVY57_RS15105 ENOG4105C25 Primosomal protein n' HVY57_RS15120 ENOG4107S01 Repressor protein MetJ HVY57_RS15130 ENOG4105C28 cystathionine HVY57_RS15135 ENOG4105CFH Aspartokinase HVY57_RS15145 ENOG4105CGH 5'-nucleotidase HVY57_RS15150 ENOG4105SYT Methylenetetrahydrofolate reductase HVY57_RS15160 ENOG4108Q5Y Membrane HVY57_RS15165 ENOG4108XC3 NADH ubiquinone oxidoreductase HVY57_RS15170 ENOG4105DCT glycerol dehydrogenase HVY57_RS15175 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY57_RS15180 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY57_RS15185 ENOG4105DM4 PTS System HVY57_RS15190 ENOG4108YRF PTS System HVY57_RS15200 ENOG4108AHH pyruvate formate lyase II activase HVY57_RS15205 ENOG4108XCZ PTS System HVY57_RS15210 ENOG4106R3P AraC family transcriptional regulator HVY57_RS15215 ENOG4105DIJ Phosphoethanolamine transferase HVY57_RS15230 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVY57_RS15245 ENOG4105C5Q Transcriptional regulator HVY57_RS15255 ENOG4105CH2 amidohydrolase HVY57_RS15265 ENOG4105EJ2 Transcriptional regulator HVY57_RS15270 ENOG4108Y73 Membrane HVY57_RS15310 ENOG4105D4A Cell wall formation (By similarity) HVY57_RS15315 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVY57_RS15350 ENOG4105PM1 preprotein translocase subunit SecE HVY57_RS15355 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVY57_RS15390 ENOG4105D41 biosynthesis protein thiH HVY57_RS15400 ENOG4105WHD thiamine biosynthesis protein ThiS HVY57_RS15405 ENOG4105D06 uba thif-type nad fad binding protein HVY57_RS15440 ENOG4105R2J Conserved Protein HVY57_RS15450 ENOG4108T8B Protein of unknown function (DUF1481) HVY57_RS15455 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVY57_RS15460 ENOG4105BZU Histidine kinase HVY57_RS15465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY57_RS15470 ENOG4105C12 Phosphoribosylglycinamide synthetase HVY57_RS15500 ENOG4105K5X acetyltransferase HVY57_RS15510 ENOG4107QP3 malate synthase g HVY57_RS15515 ENOG4108I9X Isocitrate lyase HVY57_RS15530 ENOG41069M3 Transcriptional regulator HVY57_RS15535 ENOG4105C3R Methionine synthase HVY57_RS15550 ENOG4105EAM Na Pi-cotransporter HVY57_RS15555 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVY57_RS15560 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY57_RS15565 ENOG4105F3R pts system mannose fructose sorbose family iid HVY57_RS15575 ENOG4105KPI PTS system sorbose subfamily IIB component HVY57_RS15580 ENOG4108XCU pts system HVY57_RS15585 ENOG4105CHR reductase HVY57_RS15590 ENOG4105DKT Transcriptional regulator HVY57_RS15595 ENOG4105FE9 pseudouridine synthase HVY57_RS15600 ENOG4108ZR5 Conserved Protein HVY57_RS15610 ENOG410756H nucleotidyltransferase HVY57_RS15615 ENOG4108WZA zeta toxin HVY57_RS15620 ENOG4105CFH Aspartokinase HVY57_RS15635 ENOG4108MDC (LipO)protein HVY57_RS15640 ENOG4108Q9C Periplasmic Protein HVY57_RS15645 ENOG4105E3R (LipO)protein HVY57_RS15660 ENOG4107QNK )-transporter HVY57_RS15665 ENOG4105EG2 ABC transporter, permease HVY57_RS15670 ENOG4105D56 permease protein HVY57_RS15675 ENOG4107FKK extracellular solute-binding protein family 1 HVY57_RS15680 ENOG4108IJ9 (ABC) transporter HVY57_RS15690 ENOG4107W52 maltose operon periplasmic protein HVY57_RS15710 ENOG41080IJ Diacylglycerol kinase HVY57_RS15720 ENOG4107R73 Mate efflux family protein HVY57_RS15725 ENOG4105VDW Csbd family HVY57_RS15730 ENOG4105MYN Zinc uptake regulation protein HVY57_RS15735 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY57_RS15740 ENOG4105P4Z Phage shock protein G HVY57_RS15745 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVY57_RS15750 ENOG4105CDU Replicative dna helicase HVY57_RS15760 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY57_RS15765 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY57_RS15775 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVY57_RS15780 ENOG4105CGF Aromatic amino acid aminotransferase HVY57_RS15790 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVY57_RS15795 ENOG4107QPK )-transporter HVY57_RS15800 ENOG4105DG4 malate L-lactate dehydrogenase HVY57_RS15805 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY57_RS15810 ENOG4105CQZ Histidine kinase HVY57_RS15815 ENOG4105F0S class B acid phosphatase HVY57_RS15820 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVY57_RS15825 ENOG4105MSB protein, conserved in bacteria HVY57_RS15830 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVY57_RS15835 ENOG4108UUM single-stranded DNA-binding protein HVY57_RS15840 ENOG4105PMV Membrane HVY57_RS15845 ENOG4108W3Q Transcriptional regulator HVY57_RS15850 ENOG4108Z4X TRANSCRIPTIONal HVY57_RS15855 ENOG4105C7N Xanthine uracil vitamin C permease HVY57_RS15860 ENOG4105EEQ Na H antiporter HVY57_RS15865 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVY57_RS15870 ENOG4108F5E vimentin HVY57_RS15875 ENOG4108YIV HVY57_RS15880 ENOG4105CSH Transporter HVY57_RS15885 ENOG4105ECM Sensor protein basS pmrB HVY57_RS15890 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY57_RS15895 ENOG4105DIJ Phosphoethanolamine transferase HVY57_RS15900 ENOG4106ZGR Transcriptional regulator HVY57_RS15905 ENOG4108R5S membrane HVY57_RS15910 ENOG4107GFK fumarate HVY57_RS15915 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY57_RS15920 ENOG4108MRH transcriptional regulatory protein HVY57_RS15925 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY57_RS15930 ENOG4107QY8 reductase HVY57_RS15935 ENOG4105QAX Iron-sulfur HVY57_RS15940 ENOG4107KGK dmso reductase anchor subunit HVY57_RS15945 ENOG4108NEM leader-binding protein dmsD HVY57_RS15960 ENOG4108SIC Transcriptional regulator HVY57_RS15965 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVY57_RS15975 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY57_RS15980 ENOG4108IJ0 Aspartate ammonia-lyase HVY57_RS15985 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVY57_RS15990 ENOG4105DVH amino acid HVY57_RS16005 ENOG4108ZVF (LipO)protein HVY57_RS16010 ENOG4105MTB Uncharacterized protein YjeJ HVY57_RS16015 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVY57_RS16025 ENOG4107PEH Entericidin EcnA/B family HVY57_RS16030 ENOG4106BSU Entericidin B HVY57_RS16035 ENOG4105KPY Small multidrug resistance protein HVY57_RS16040 ENOG4105QNF Outer membrane lipoprotein HVY57_RS16045 ENOG41066YJ Beta-lactamase HVY57_RS16060 ENOG4105E33 succinate dehydrogenase HVY57_RS16065 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY57_RS16075 ENOG4107SC7 Inner membrane transporter yjeM HVY57_RS16080 ENOG4106CG8 Inner membrane protein YjeO HVY57_RS16085 ENOG4105EGS Mechanosensitive ion channel HVY57_RS16105 ENOG4106TNF Periplasmic binding protein HVY57_RS16130 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVY57_RS16135 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVY57_RS16140 ENOG4105K8N protein family UPF0079, ATPase HVY57_RS16145 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY57_RS16165 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVY57_RS16170 ENOG4107QJR hflk protein HVY57_RS16175 ENOG4105EPW hflc protein HVY57_RS16195 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVY57_RS16200 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVY57_RS16205 ENOG4105FUX Conserved Protein HVY57_RS16210 ENOG4108P9J Phage shock protein A HVY57_RS16215 ENOG4107VNS Protein of unknown function (DUF2491) HVY57_RS16220 ENOG4105Z6B inner membrane protein yjfl HVY57_RS16225 ENOG4108KXT Conserved Protein HVY57_RS16230 ENOG4106032 Glutathionylspermidine synthase HVY57_RS16235 ENOG4105CSU acyl-Coa dehydrogenase HVY57_RS16240 ENOG4105S17 UPF0379 protein yjfN HVY57_RS16245 ENOG4105WSB biofilm stress and motility protein A HVY57_RS16250 ENOG4108MXZ Esterase HVY57_RS16255 ENOG4105DW5 Transcriptional regulator HVY57_RS16265 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY57_RS16270 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVY57_RS16295 ENOG4105KIT UPF0379 protein yjfY HVY57_RS16310 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVY57_RS16320 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY57_RS16325 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY57_RS16330 ENOG41069H7 transport system small permease component HVY57_RS16335 ENOG4107S3R L-aspartate oxidase HVY57_RS16340 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVY57_RS16365 ENOG4105CHR reductase HVY57_RS16375 ENOG4105FHY Opacity-associated protein A HVY57_RS16380 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY57_RS16395 ENOG4105DXC membrane HVY57_RS16400 ENOG4105ECR NmrA family HVY57_RS16405 ENOG4105KVH Transcriptional regulator HVY57_RS16410 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVY57_RS16415 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVY57_RS16420 ENOG4108UUE Transcriptional regulator HVY57_RS16425 ENOG41061GZ Protein of unknown function (DUF1107) HVY57_RS16430 ENOG4105C37 (CBS) domain HVY57_RS16435 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVY57_RS16445 ENOG4108YZG isomerase HVY57_RS16450 ENOG4105NYY transcriptional regulator, RpiR HVY57_RS16455 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY57_RS16460 ENOG4105C2J ABC transporter HVY57_RS16465 ENOG4105CNN ABC, transporter HVY57_RS16470 ENOG4105UP7 3-epimerase HVY57_RS16475 ENOG4107TFG D-allose kinase HVY57_RS16490 ENOG4108MI0 Resistance protein HVY57_RS16495 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVY57_RS16505 ENOG41082ND Uncharacterized protein yjcO HVY57_RS16510 ENOG4105CK2 sodium dicarboxylate symporter HVY57_RS16515 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY57_RS16520 ENOG41062QD Membrane HVY57_RS16535 ENOG4105CFU surface antigen HVY57_RS16540 ENOG4105MA0 exported protein HVY57_RS16545 ENOG4108ZHD aig2 family HVY57_RS16550 ENOG4105F0N pyrophosphate phospho-hydrolase HVY57_RS16555 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVY57_RS16560 ENOG4105C2J ABC transporter HVY57_RS16565 ENOG4107R9N ABC transporter HVY57_RS16570 ENOG41062B0 ABC transporter, permease HVY57_RS16580 ENOG4105DFU Cell wall formation (By similarity) HVY57_RS16590 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVY57_RS16595 ENOG4108XVM Cytochrome b(562) HVY57_RS16605 ENOG4105K4U addiction module toxin, RelE StbE family HVY57_RS16610 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVY57_RS16615 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVY57_RS16620 ENOG4105CG3 alpha amylase, catalytic region HVY57_RS16625 ENOG4105C5Y PTS System HVY57_RS16630 ENOG4105D4X repressor HVY57_RS16640 ENOG4105KME endoribonuclease L-psp HVY57_RS16655 ENOG4107C93 pyrBI operon leader peptide HVY57_RS16665 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVY57_RS16670 ENOG4105DBV ornithine carbamoyltransferase HVY57_RS16685 ENOG4105XEP YhcH YjgK YiaL family protein HVY57_RS16690 ENOG4105DBV ornithine carbamoyltransferase HVY57_RS16695 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVY57_RS16700 ENOG4108MJ3 acetyltransferase HVY57_RS16730 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVY57_RS16735 ENOG4105MYG DNA polymerase iii, chi subunit HVY57_RS16745 ENOG4108M8S permease YjgP YjgQ family protein HVY57_RS16750 ENOG4108K5H permease YjgP YjgQ family protein HVY57_RS16755 ENOG4105W4M Transport-associated protein HVY57_RS16775 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVY57_RS16780 ENOG4106HBN Galactosamine-6-phosphate isomerase HVY57_RS16785 ENOG4105F3R pts system mannose fructose sorbose family iid HVY57_RS16790 ENOG4105ETZ PTS System HVY57_RS16795 ENOG4108UZY PTS System HVY57_RS16805 ENOG4105E70 isomerase HVY57_RS16810 ENOG4105CE4 GlcNAc 6-P deacetylase HVY57_RS16815 ENOG4108YTN IIa component HVY57_RS16820 ENOG4105F3R pts system mannose fructose sorbose family iid HVY57_RS16830 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVY57_RS16840 ENOG4105E98 transcriptional regulator DeoR family HVY57_RS16845 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HVY57_RS16850 ENOG4105ZEG Suppressor protein HVY57_RS16855 ENOG4105CTX dehydratase HVY57_RS16865 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY57_RS16875 ENOG4108CNN domain protein HVY57_RS16880 ENOG4105CWB LysR family transcriptional Regulator HVY57_RS16900 ENOG4105CHF Glutathione S-transferase HVY57_RS16905 ENOG4108VBZ doxx family HVY57_RS16910 ENOG4105YJD HVY57_RS16915 ENOG41090KG Inner membrane protein YqjE HVY57_RS16920 ENOG4105NE1 Conserved Protein HVY57_RS16925 ENOG4105WAY exported protein HVY57_RS16935 ENOG4106W5V Membrane HVY57_RS16940 ENOG4107YCY Transcriptional regulator HVY57_RS16945 ENOG4105DPW Major facilitator superfamily MFS_1 HVY57_RS16955 ENOG4105CTX dehydratase HVY57_RS16960 ENOG4105P66 Membrane HVY57_RS16965 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVY57_RS16970 ENOG4105DU1 integral membrane protein, terc HVY57_RS16975 ENOG4105EE0 oxidoreductase HVY57_RS16980 ENOG4108UB4 uncharacterized protein ygjQ HVY57_RS16985 ENOG4108VKG metal-dependent hydrolase HVY57_RS17005 ENOG4105RI1 glycoprotein receptor HVY57_RS17010 ENOG4106CVF DNA replication protein HVY57_RS17015 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HVY57_RS17020 ENOG4107XM3 UPF0442 protein HVY57_RS17025 ENOG4105DWK Membrane HVY57_RS17030 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HVY57_RS17035 ENOG4105EZV Transcriptional regulator HVY57_RS17040 ENOG4108N8T regulatoR HVY57_RS17045 ENOG4108T94 DNA-binding transcriptional activator BglJ HVY57_RS17050 ENOG4108819 ferric iron reductase HVY57_RS17055 ENOG4105YBH Protein of unknown function (DUF1435) HVY57_RS17075 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVY57_RS17080 ENOG4108WPU DNA polymerase III subunit psi HVY57_RS17085 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVY57_RS17090 ENOG4105PAD Hydrolase HVY57_RS17110 ENOG4108R7K Metal Dependent Phosphohydrolase HVY57_RS17115 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HVY57_RS17120 ENOG4105H40 HVY57_RS17135 ENOG4108S1U HVY57_RS17140 ENOG4105HGD Antitermination protein HVY57_RS17155 ENOG4105VEQ Cold shock protein HVY57_RS17160 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY57_RS17180 ENOG4108YV9 Protein of unknown function (DUF2514) HVY57_RS17185 ENOG4105VEQ Cold shock protein HVY57_RS17195 ENOG4106IAW HVY57_RS17200 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVY57_RS17225 ENOG4105UZW Tail fiber assembly protein HVY57_RS17230 ENOG4105MN3 Resolvase HVY57_RS17235 ENOG4105W3V DNA-binding, transcriptional regulator HVY57_RS17245 ENOG4106FE3 DNA repair HVY57_RS17255 ENOG4105K3G Periplasmic Protein HVY57_RS17265 ENOG4108NRW Phospholipase, patatin family HVY57_RS17270 ENOG4105EYA deoxyribonuclease HVY57_RS17275 ENOG41076CZ activating enzyme HVY57_RS17280 ENOG4105G0K glycine radical enzyme YjjI family HVY57_RS17315 ENOG41062Z9 Membrane HVY57_RS17320 ENOG4105EAC phosphoserine phosphatase HVY57_RS17325 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVY57_RS17330 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVY57_RS17335 ENOG4105C5H ABC transporter HVY57_RS17340 ENOG4107SC1 transglycosylase HVY57_RS17350 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVY57_RS17360 ENOG4105UEI Transcriptional Regulator AraC Family HVY57_RS17365 ENOG4108RH0 Crea protein HVY57_RS17370 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY57_RS17375 ENOG4105EB3 Histidine kinase HVY57_RS17380 ENOG4105CT7 inner membrane cred family protein HVY57_RS17385 ENOG41065U4 response regulator HVY57_RS17390 ENOG410759A HVY57_RS17395 ENOG4106FVC RNA methyltransferase HVY57_RS17405 ENOG4105CFH Aspartokinase HVY57_RS17415 ENOG4105D98 threonine synthase HVY57_RS17420 ENOG41062C6 Protein of unknown function (DUF2502) HVY57_RS17430 ENOG4105BZG amino acid carrier protein HVY57_RS17440 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY57_RS17445 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVY57_RS17460 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVY57_RS17470 ENOG41063Z6 transcriptional regulator, lysR family HVY57_RS17480 ENOG410647N response to DNA damage stimulus HVY57_RS17485 ENOG4105DTN riboflavin biosynthesis protein ribF HVY57_RS17490 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HVY57_RS17500 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVY57_RS17535 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY57_RS17540 ENOG4105D9Q decarboxylase (Beta subunit) HVY57_RS17545 ENOG4107QSA Oxaloacetate decarboxylase HVY57_RS17555 ENOG4105D2K citrate carrier protein HVY57_RS17560 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVY57_RS17570 ENOG4105CI0 Citrate lyase HVY57_RS17575 ENOG4105CHY citrate lyase, alpha HVY57_RS17600 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVY57_RS17605 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVY57_RS17610 ENOG4108XNW Transcriptional activatory protein CaiF HVY57_RS17620 ENOG4106YT9 Enoyl-CoA hydratase HVY57_RS17655 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVY57_RS17660 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVY57_RS17665 ENOG4105C54 Major Facilitator superfamily HVY57_RS17680 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVY57_RS17715 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVY57_RS17725 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVY57_RS17730 ENOG4105D3G Pseudouridine synthase HVY57_RS17735 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVY57_RS17740 ENOG4105CQ2 DNA polymerase HVY57_RS17745 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY57_RS17780 ENOG4108RVA ribokinase HVY57_RS17805 ENOG4108KF1 Membrane HVY57_RS17815 ENOG4106SMU thiamine transporter membrane protein HVY57_RS17820 ENOG4105DP9 ABC transporter HVY57_RS17825 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HVY57_RS17835 ENOG4105S8Q sugar efflux transporter HVY57_RS17840 ENOG4105DJB Major Facilitator Superfamily HVY57_RS17845 ENOG4105DND Transcriptional regulator HVY57_RS17850 ENOG4105FF2 Type I DHQase HVY57_RS17855 ENOG4105EMV Major Facilitator HVY57_RS17895 ENOG41064T2 transcriptional regulator, lysR family HVY57_RS17900 ENOG4105C7K acetolactate synthase HVY57_RS17905 ENOG4108ZP8 Acetolactate synthase small subunit HVY57_RS17915 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVY57_RS17930 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVY57_RS17935 ENOG4105CJN penicillin-binding protein HVY57_RS17940 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVY57_RS17945 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVY57_RS17955 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVY57_RS17960 ENOG4105CNI cell division protein FtsW HVY57_RS17975 ENOG4105CPF Cell wall formation (By similarity) HVY57_RS17980 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVY57_RS17985 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVY57_RS17990 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVY57_RS18010 ENOG4105M6F mutator MutT protein HVY57_RS18025 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVY57_RS18035 ENOG4105D7Q type ii secretion system HVY57_RS18040 ENOG4107QHF type ii secretion system protein e HVY57_RS18045 ENOG4108ZUW Major pilin subunit HVY57_RS18050 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVY57_RS18055 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY57_RS18060 ENOG4106A72 regulatory protein AmpE HVY57_RS18065 ENOG4105C85 amino acid HVY57_RS18070 ENOG41073TP transcriptional regulator HVY57_RS18075 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVY57_RS18080 ENOG4107QSN dihydrolipoamide acetyltransferase HVY57_RS18085 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY57_RS18090 ENOG4108NST exported protein HVY57_RS18095 ENOG4107QIJ Aconitate hydratase 2 HVY57_RS18115 ENOG4108ZRK uncharacterized protein yacC HVY57_RS18120 ENOG4105E3B Multicopper oxidase HVY57_RS18125 ENOG4105DZG Dehydrogenase HVY57_RS18130 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVY57_RS18135 ENOG41077A9 carbonic anhydrase HVY57_RS18140 ENOG4105DA5 (ABC) transporter HVY57_RS18145 ENOG4105E3A (ABC) transporter HVY57_RS18150 ENOG4108YTN IIa component HVY57_RS18155 ENOG4107BJW polysaccharide deacetylase HVY57_RS18165 ENOG4108A32 Transposase HVY57_RS18190 ENOG4105SYG Fimbrial protein HVY57_RS18195 ENOG4108XEY fimbrial-like adhesin protein HVY57_RS18200 ENOG4105CW0 outer membrane usher protein HVY57_RS18205 ENOG4108VEV chaperone HVY57_RS18215 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVY57_RS18220 ENOG4105DJ0 Poly(A) Polymerase HVY57_RS18240 ENOG4107XID 2'-5' rna ligase HVY57_RS18245 ENOG4105CQ7 ATP-dependent helicase HVY57_RS18250 ENOG4105BZ4 penicillin-binding protein HVY57_RS18255 ENOG4105E0K tonB-dependent siderophore receptor HVY57_RS18260 ENOG4105E0A ABC, transporter HVY57_RS18265 ENOG4105J76 Periplasmic binding protein HVY57_RS18270 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVY57_RS18295 ENOG4105EN6 Membrane HVY57_RS18300 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVY57_RS18315 ENOG4105C0H protease HVY57_RS18320 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVY57_RS18330 ENOG4105DIN metallophosphoesterase HVY57_RS18345 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVY57_RS18370 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVY57_RS18375 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVY57_RS18380 ENOG4105KNE Phosphatidate cytidylyltransferase HVY57_RS18385 ENOG4105DZP Membrane-associated zinc metalloprotease HVY57_RS18395 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVY57_RS18400 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVY57_RS18420 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HVY57_RS18425 ENOG4105C0B DNA polymerase III (alpha subunit) HVY57_RS18430 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HVY57_RS18435 ENOG4105CXN decarboxylase HVY57_RS18440 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVY57_RS18445 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVY57_RS18450 ENOG4105M1T rho-binding antiterminator HVY57_RS18460 ENOG4108VWS Yaeq family HVY57_RS18465 ENOG4108YZN class I peptide chain release factor HVY57_RS18470 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVY57_RS18475 ENOG4108UY0 (LipO)protein HVY57_RS18485 ENOG4108R96 Methyltransferase, YaeB family HVY57_RS18490 ENOG4108R8X outer membrane lipoprotein HVY57_RS18495 ENOG4105D01 (LipO)protein HVY57_RS18500 ENOG4108UMI ABC transporter, permease HVY57_RS18505 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVY57_RS18510 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVY57_RS18545 ENOG4105DFP Integrase HVY57_RS18550 ENOG4105HVQ Regulatory factor of maltose metabolism HVY57_RS18635 ENOG4105CV8 reductase HVY57_RS18640 ENOG4105HEI LysR family (Transcriptional regulator HVY57_RS18650 ENOG4105F2W methyltransferase HVY57_RS18655 ENOG4105E9H Lytic Murein transglycosylase HVY57_RS18665 ENOG4105D1A Methyltransferase HVY57_RS18675 ENOG4107RZZ dna polymerase iii epsilon subunit HVY57_RS18685 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY57_RS18690 ENOG4108WN0 inhibitor of vertebrate lysozyme HVY57_RS18695 ENOG4107QPN acyl-Coa dehydrogenase HVY57_RS18705 ENOG4105E7A Glutamine amidotransferase HVY57_RS18710 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVY57_RS18715 ENOG4108YS0 lipoprotein YafL HVY57_RS18725 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY57_RS18745 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVY57_RS18750 ENOG4105CUZ uba thif-type nad fad binding protein HVY57_RS18755 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVY57_RS18760 ENOG4105C9B Cysteine desulfurase HVY57_RS18765 ENOG4105M5B (LipO)protein HVY57_RS18770 ENOG4105ETT transcriptional Regulator, LysR family HVY57_RS18775 ENOG4105M08 Membrane HVY57_RS18790 ENOG4105EJQ L-serine dehydratase HVY57_RS18795 ENOG4105C44 Serine transporter HVY57_RS18800 ENOG4105EWT decarboxylase family HVY57_RS18815 ENOG4105WP7 tRNA pseudouridine synthase C HVY57_RS18820 ENOG4105DR9 pseudouridine synthase HVY57_RS18825 ENOG4105QDK Flavodoxin HVY57_RS18830 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVY57_RS18855 ENOG4105EQX glucarate dehydratase HVY57_RS18860 ENOG4105EQX glucarate dehydratase HVY57_RS18865 ENOG4105BZW Glycerate kinase HVY57_RS18870 ENOG4105BZU Histidine kinase HVY57_RS18875 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVY57_RS18880 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY57_RS18885 ENOG4105DXN mazG family HVY57_RS18900 ENOG4105HA9 of methanol dehydrogenase type HVY57_RS18910 ENOG4105HA9 of methanol dehydrogenase type HVY57_RS18920 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVY57_RS18930 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVY57_RS18945 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HVY57_RS18955 ENOG4105CYR Crispr-associated protein, cse1 family HVY57_RS18960 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) HVY57_RS18965 ENOG41060M0 Crispr-associated protein, cse4 family HVY57_RS18970 ENOG4108VWQ crispr-associated protein HVY57_RS18975 ENOG4108Y7V CRISPR-associated protein, Cse3 family HVY57_RS18980 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVY57_RS18985 ENOG4105PWE CRISPR-associated protein cas2 HVY57_RS18990 ENOG4108MXK alkaline phosphatase isozyme conversion HVY57_RS19010 ENOG4105N0Z inner membrane protein ygbE HVY57_RS19045 ENOG4108K5P (LipO)protein HVY57_RS19050 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY57_RS19070 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY57_RS19075 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY57_RS19080 ENOG4105KZM cytoplasmic protein HVY57_RS19085 ENOG4105MEW serine threonine protein phosphatase HVY57_RS19105 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVY57_RS19120 ENOG4105C2J ABC transporter HVY57_RS19125 ENOG4105CNN ABC, transporter HVY57_RS19145 ENOG4107EDW L-fucose operon activator HVY57_RS19150 ENOG4105VXR cytoplasmic protein HVY57_RS19160 ENOG4108JUA Transcriptional regulator HVY57_RS19165 ENOG4105C45 hydrogenase expression formation protein (HypE) HVY57_RS19170 ENOG4105CQS hydrogenase expression formation protein HypD HVY57_RS19175 ENOG41083WG hydrogenase assembly chaperone HVY57_RS19180 ENOG4107RSS Hydrogenase accessory protein HypB HVY57_RS19185 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVY57_RS19190 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVY57_RS19195 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY57_RS19200 ENOG4107R30 NADH dehydrogenase HVY57_RS19205 ENOG4107TDF Formate hydrogenlyase subunit 4 HVY57_RS19210 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY57_RS19215 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVY57_RS19220 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY57_RS19225 ENOG4105I6X formate hydrogenlyase maturation HVY57_RS19230 ENOG4108MG9 hydrogenase 3 maturation protease HVY57_RS19235 ENOG4105CS2 ec 3.2.1.21 HVY57_RS19240 ENOG4105C5Y PTS System HVY57_RS19245 ENOG4105DDV Transcriptional regulator (LacI family HVY57_RS19250 ENOG4108RC0 Electron transport protein HVY57_RS19255 ENOG4105C8H hydrogenase maturation protein Hypf HVY57_RS19275 ENOG4105C2X Arabinose 5-phosphate isomerase HVY57_RS19285 ENOG4105CVE Lytic murein transglycosylase HVY57_RS19295 ENOG4107TH8 cina domain protein HVY57_RS19315 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVY57_RS19345 ENOG4107VXZ Hydrolase HVY57_RS19350 ENOG4105W39 Membrane HVY57_RS19365 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY57_RS19370 ENOG4105CW7 secretion protein, HlyD family HVY57_RS19375 ENOG4105NTK Transcriptional repressor Mpra HVY57_RS19380 ENOG4105ZED uncharacterized protein ygaH HVY57_RS19385 ENOG4108UMN azlc family HVY57_RS19395 ENOG4105GIJ Glycine betaine HVY57_RS19400 ENOG4108HQS Glycine betaine HVY57_RS19405 ENOG4108IJ7 Glycine betaine HVY57_RS19410 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY57_RS19415 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY57_RS19425 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVY57_RS19430 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY57_RS19440 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVY57_RS19445 ENOG4108WMJ Protein of unknown function (DUF2002) HVY57_RS19455 ENOG4108X73 DNA- binding protein HVY57_RS19460 ENOG4108V62 Rhodanese domain protein HVY57_RS19465 ENOG41080HT Transcriptional regulator, arsr family HVY57_RS19470 ENOG4105VPI YqaE family transport protein HVY57_RS19475 ENOG4109066 lysm domain bon superfamily protein HVY57_RS19480 ENOG4108PVQ transcriptional regulator HVY57_RS19485 ENOG4105C85 amino acid HVY57_RS19490 ENOG4108JPW Aminotransferase HVY57_RS19495 ENOG4105C26 Dehydrogenase HVY57_RS19500 ENOG4105D5U fad dependent oxidoreductase HVY57_RS19520 ENOG4108NUU Transcriptional regulator HVY57_RS19525 ENOG4105SZ2 membrAne HVY57_RS19530 ENOG4107SNB ankyrin repeat protein YahD HVY57_RS19535 ENOG4105N16 Protein of unknown function (DUF2877) HVY57_RS19540 ENOG4107R1Q Membrane protein FdrA HVY57_RS19545 ENOG4107REC cytoplasmic protein HVY57_RS19550 ENOG4105C5B carbamate kinase HVY57_RS19555 ENOG4105DZC cytosine deaminase HVY57_RS19560 ENOG4105DTA methyltransferase HVY57_RS19570 ENOG4105DQ4 alcohol dehydrogenase HVY57_RS19575 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY57_RS19580 ENOG4108YZG isomerase HVY57_RS19590 ENOG4105CMT Dihydroxyacetone kinase HVY57_RS19595 ENOG4105CP7 Triose-phosphate isomerase HVY57_RS19600 ENOG4108KFM Xylose Isomerase Domain-Containing protein HVY57_RS19605 ENOG4106J7G oxidoreductase HVY57_RS19610 ENOG4105DKT Transcriptional regulator HVY57_RS19615 ENOG41083A2 UPF0145 protein HVY57_RS19620 ENOG4105Y50 Virulence Protein HVY57_RS19675 ENOG4105DFP Integrase HVY57_RS19690 ENOG4108Z1B Cyclase dehydrase HVY57_RS19700 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY57_RS19705 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVY57_RS19720 ENOG4108JU6 CBS domain protein HVY57_RS19725 ENOG4106KVJ cytochrome C assembly protein HVY57_RS19730 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVY57_RS19755 ENOG4105QP9 Protein of unknown function (DUF2799) HVY57_RS19760 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY57_RS19765 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVY57_RS19770 ENOG4105CQC Prephenate dehydratase HVY57_RS19780 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVY57_RS19785 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVY57_RS19790 ENOG4105C34 Pseudouridine synthase HVY57_RS19795 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVY57_RS19800 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY57_RS19825 ENOG4105CSH Transporter HVY57_RS19830 ENOG4105T42 (LipO)protein HVY57_RS19835 ENOG4105JIM Phosphatidylserine synthase HVY57_RS19840 ENOG4105CD5 CoA-binding domain protein HVY57_RS19845 ENOG4106IUH DTW domain containing protein HVY57_RS19850 ENOG4105K63 Thioredoxin HVY57_RS19855 ENOG4105EIB trna rrna methyltransferase HVY57_RS19880 ENOG4105C1J atp-dependent rna helicase HVY57_RS19890 ENOG4108IYU L-aspartate oxidase HVY57_RS19900 ENOG4105EMN RNA polymerase sigma factor HVY57_RS19905 ENOG41069PW sigma-e factor negative regulatory protein HVY57_RS19910 ENOG4105VQK sigma E regulatory protein, MucB RseB HVY57_RS19915 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVY57_RS19925 ENOG4105C3F Signal peptidase i HVY57_RS19945 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVY57_RS19960 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVY57_RS19965 ENOG4106G6Q Transcriptional regulator HVY57_RS19970 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVY57_RS19975 ENOG4108Z6B deaminase HVY57_RS19985 ENOG4108ETH Formylglycinamide ribotide synthetase HVY57_RS19990 ENOG4107WP9 Histidine kinase HVY57_RS19995 ENOG4108SKK alpha helix protein HVY57_RS20000 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY57_RS20025 ENOG4107RE1 Inosine-guanosine kinase HVY57_RS20040 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVY57_RS20045 ENOG4105EU0 Major facilitator Superfamily HVY57_RS20050 ENOG4105CGH 5'-nucleotidase HVY57_RS20055 ENOG4108Z66 YbaK ebsC protein HVY57_RS20060 ENOG4105MBR gumn family HVY57_RS20065 ENOG4105EQR Transposase IS116 IS110 IS902 HVY57_RS20070 ENOG4105C59 p-type ATPase HVY57_RS20075 ENOG4107RY6 amino acid HVY57_RS20095 ENOG4107QZV Type I secretion membrane fusion protein HVY57_RS20100 ENOG4108Z6Z Transcriptional regulator HVY57_RS20105 ENOG4105G5H Membrane HVY57_RS20110 ENOG4107QX8 SPFH domain, Band 7 family protein HVY57_RS20115 ENOG41083J0 (ABC) transporter HVY57_RS20120 ENOG4105C4B ABC transporter, permease HVY57_RS20125 ENOG4107QR8 Thioredoxin HVY57_RS20130 ENOG4105E1F short-chain dehydrogenase reductase HVY57_RS20135 ENOG4108UJV acyl-CoA thioesterase i HVY57_RS20140 ENOG4108I0Y (ABC) transporter HVY57_RS20145 ENOG4105CV6 ABC transporter, permease HVY57_RS20150 ENOG4105GMB type VI secretion system effector, hcp1 family HVY57_RS20165 ENOG4105G5A Protein of unknown function (DUF2877) HVY57_RS20170 ENOG4105C5B carbamate kinase HVY57_RS20175 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVY57_RS20180 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVY57_RS20190 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY57_RS20200 ENOG4105S2T inner membrane protein YbcI HVY57_RS20205 ENOG4105WQ3 Rna-binding protein HVY57_RS20220 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY57_RS20230 ENOG4108SB3 DoxX Family HVY57_RS20240 ENOG4105D8G Major Facilitator superfamily HVY57_RS20245 ENOG4108MN2 Stationary phase inducible protein CsiE HVY57_RS20250 ENOG4107XM9 (LipO)protein HVY57_RS20255 ENOG4105ECY inositol monophosphatase HVY57_RS20275 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVY57_RS20295 ENOG4108ZIT Ferredoxin, 2FE-2S HVY57_RS20300 ENOG4105WVQ Fe-S assembly protein IscX HVY57_RS20310 ENOG4105YYA enhanced serine sensitivity protein SseB HVY57_RS20315 ENOG4105KHC sulfurtransferase HVY57_RS20320 ENOG4105DN3 alpha-2-macroglobulin domain protein HVY57_RS20325 ENOG4108JQB penicillin-binding protein 1C HVY57_RS20355 ENOG4105N21 Membrane HVY57_RS20370 ENOG4105VPD cellular component movement HVY57_RS20395 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVY57_RS20410 ENOG4108R1E Serine threonine protein phosphatase 1 HVY57_RS20450 ENOG4105F2I Transposase HVY57_RS20460 ENOG4105C9X ppx gppa phosphatase HVY57_RS20465 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVY57_RS20470 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVY57_RS20485 ENOG4105C2W permease HVY57_RS20490 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVY57_RS20495 ENOG4105K89 arsenate reductase HVY57_RS20500 ENOG4105ERG peptidase m48, ste24p HVY57_RS20505 ENOG4105C02 permease HVY57_RS20510 ENOG4108JUA Transcriptional regulator HVY57_RS20515 ENOG4105I6X formate hydrogenlyase maturation HVY57_RS20520 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY57_RS20530 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY57_RS20540 ENOG4107WQX hydrogenase 4 membrane subunit HVY57_RS20555 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY57_RS20560 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVY57_RS20565 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVY57_RS20575 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY57_RS20590 ENOG4105CGZ zinc metallopeptidase HVY57_RS20600 ENOG4106KED esterase YpfH HVY57_RS20615 ENOG4105KUZ arsenate reductase HVY57_RS20625 ENOG4105BZS acriflavin resistance protein HVY57_RS20630 ENOG4105BZU Histidine kinase HVY57_RS20635 ENOG4105BZ8 glutamate synthase HVY57_RS20645 ENOG4108PVD exported protein HVY57_RS20650 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY57_RS20655 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY57_RS20660 ENOG4105C6K Malic enzyme HVY57_RS20670 ENOG4107H8F HVY57_RS20680 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVY57_RS20690 ENOG4105QZU Inner membrane protein YfeZ HVY57_RS20695 ENOG4105E7K (LipO)protein HVY57_RS20700 ENOG4105EZR dyp-type peroxidase family protein HVY57_RS20705 ENOG4107S1E Beta-lactamase HVY57_RS20710 ENOG4105C5Y PTS System HVY57_RS20725 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVY57_RS20730 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVY57_RS20735 ENOG4108I5D sulfate abc transporter HVY57_RS20740 ENOG4105ECW sulfate abc transporter HVY57_RS20745 ENOG4108IJ6 ABC transporter HVY57_RS20750 ENOG4105C6T cysteine synthase HVY57_RS20755 ENOG4105M0Y HVY57_RS20765 ENOG4105C5Y PTS System HVY57_RS20770 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY57_RS20780 ENOG4105C6T cysteine synthase HVY57_RS20790 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HVY57_RS20800 ENOG4105VRT cytoplasmic protein HVY57_RS20805 ENOG4105DHU Bile acid HVY57_RS20810 ENOG4108NFH Sugar hydrolase HVY57_RS20815 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVY57_RS20820 ENOG4105EAA nucleoside HVY57_RS20830 ENOG4105CN8 Transcriptional regulator HVY57_RS20855 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HVY57_RS20860 ENOG4105GXM Putative transcription regulator (DUF1323) HVY57_RS20865 ENOG4105HZG regulatoR HVY57_RS20880 ENOG4108KMM Diguanylate cyclase HVY57_RS20885 ENOG4105D9N nucleoside HVY57_RS20895 ENOG4109076 Conserved Protein HVY57_RS20910 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVY57_RS20915 ENOG410863U PTS System HVY57_RS20920 ENOG4105DC7 peptidase M24 HVY57_RS20925 ENOG4105CN9 Peptidase m42 family protein HVY57_RS20930 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY57_RS20935 ENOG4108CIP transcriptional regulator HVY57_RS20940 ENOG4105DY9 regulatoR HVY57_RS20945 ENOG4108HRK Histidine kinase HVY57_RS20950 ENOG4105CHM Aminotransferase HVY57_RS20960 ENOG4105D1S lipid A biosynthesis HVY57_RS20965 ENOG4105W9M Membrane HVY57_RS20980 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HVY57_RS21000 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HVY57_RS21010 ENOG4105CHR reductase HVY57_RS21020 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HVY57_RS21035 ENOG4105CKK Glycosyl transferase, family 2 HVY57_RS21040 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVY57_RS21045 ENOG4105DFP Integrase HVY57_RS21055 ENOG4105S64 Formate nitrite transporter HVY57_RS21060 ENOG410903C (LipO)protein HVY57_RS21065 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVY57_RS21070 ENOG4105KZW UPF0381 protein HVY57_RS21085 ENOG4108BY2 phosphohistidine phosphatase HVY57_RS21095 ENOG4106PG1 outer membrane usher protein HVY57_RS21100 ENOG4108FZ9 Chaperone HVY57_RS21105 ENOG4105NEV Fimbrial HVY57_RS21110 ENOG4105UGQ Fimbrial HVY57_RS21115 ENOG4105US4 fimbrial-like protein yfcP HVY57_RS21135 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HVY57_RS21145 ENOG4105EJ9 Membrane HVY57_RS21150 ENOG4108BPE -transporting atpase HVY57_RS21155 ENOG4105MH2 YfcL protein HVY57_RS21160 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVY57_RS21165 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY57_RS21170 ENOG4105F9N Major Facilitator Superfamily HVY57_RS21175 ENOG4106WZ1 flagella biosynthesis regulator HVY57_RS21240 ENOG4105UZW Tail fiber assembly protein HVY57_RS21250 ENOG4108X9F tail fiber protein HVY57_RS21250 ENOG4108X9F tail fiber protein HVY57_RS21330 ENOG4105ED4 portal protein HVY57_RS21340 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HVY57_RS21355 ENOG4105VZ1 Replication Protein HVY57_RS21420 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY57_RS21430 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY57_RS21440 ENOG4105DQR SNARE associated Golgi HVY57_RS21450 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVY57_RS21455 ENOG4108S3P Sporulation domain protein HVY57_RS21460 ENOG4105E96 Colicin v production protein HVY57_RS21465 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVY57_RS21470 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY57_RS21475 ENOG4105E89 ABC transporter HVY57_RS21480 ENOG4105E89 ABC transporter HVY57_RS21485 ENOG4105DSP amino acid AbC transporter HVY57_RS21490 ENOG4106YG3 ABC transporter HVY57_RS21495 ENOG4108JEH abc transporter atp-binding protein HVY57_RS21500 ENOG4105DNE Transposase HVY57_RS21505 ENOG4105ECP epimerase HVY57_RS21510 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVY57_RS21515 ENOG4105CYM Glutathione S-transferase HVY57_RS21520 ENOG4108SHQ Glutathione S-transferase HVY57_RS21525 ENOG4108RE9 Phosphodiesterase HVY57_RS21530 ENOG4105PTV Nudix Hydrolase HVY57_RS21535 ENOG4105K2J Transcriptional regulator HVY57_RS21550 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY57_RS21555 ENOG4108HHA Transketolase HVY57_RS21560 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVY57_RS21565 ENOG4105C6K Malic enzyme HVY57_RS21570 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVY57_RS21580 ENOG4105XWI UPF0304 protein HVY57_RS21585 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVY57_RS21590 ENOG4107QWE )-transporter HVY57_RS21595 ENOG4105DK2 UPF0207 protein HVY57_RS21600 ENOG4105CHM Aminotransferase HVY57_RS21605 ENOG4107NQ8 LysR family Transcriptional regulator HVY57_RS21625 ENOG4105GKE subunit e HVY57_RS21630 ENOG4107QIZ NADH dehydrogenase HVY57_RS21635 ENOG4108IEH NADH dehydrogenase subunit g HVY57_RS21650 ENOG4107UFS subunit j HVY57_RS21660 ENOG4105D65 subunit l HVY57_RS21665 ENOG4105C8S subunit m HVY57_RS21675 ENOG4106EES HVY57_RS21685 ENOG4105GDX Domain of unknown function (DUF1877) HVY57_RS21690 ENOG4105CP2 von willebrand factor, type a HVY57_RS21705 ENOG4107YB6 acetyltransferase, (GNAT) family HVY57_RS21710 ENOG4105TNS Conserved Protein HVY57_RS21715 ENOG4105E4F Isochorismate synthase HVY57_RS21730 ENOG4108IPT Naphthoate synthase HVY57_RS21740 ENOG4105CEY Amp-dependent synthetase and ligase HVY57_RS21745 ENOG4106GZG polymyxin resistance protein B HVY57_RS21795 ENOG4108UII YfaZ family HVY57_RS21800 ENOG4108EWA cinA-like protein HVY57_RS21810 ENOG4105DNE Transposase HVY57_RS21815 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY57_RS21825 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVY57_RS21830 ENOG4105CXY transporter HVY57_RS21835 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVY57_RS21845 ENOG4105XPH Ferredoxin HVY57_RS21850 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY57_RS21855 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY57_RS21860 ENOG4107GHC outer membrane autotransporter HVY57_RS21870 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY57_RS21875 ENOG4105CHU acetyl-coa acetyltransferase HVY57_RS21880 ENOG4105CRW Short chain fatty acid transporter HVY57_RS21885 ENOG4107QNJ CoA-transferase subunit B HVY57_RS21890 ENOG4107QP7 CoA-transferase subunit A HVY57_RS21895 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY57_RS21905 ENOG4105BZU Histidine kinase HVY57_RS21910 ENOG41068CG regulatoR HVY57_RS21915 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVY57_RS21920 ENOG4105FCK Membrane HVY57_RS21925 ENOG4105CJ2 (LipO)protein HVY57_RS21930 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY57_RS21935 ENOG4105CF1 Alkylated DNA repair protein HVY57_RS21940 ENOG4105IBP Cyclic peptide transporter HVY57_RS21950 ENOG4105CDA abc transporter atp-binding protein HVY57_RS21955 ENOG4105E5Q amino acid AbC transporter HVY57_RS21960 ENOG4107R0W ABC transporter HVY57_RS21970 ENOG4107AQZ Membrane HVY57_RS21975 ENOG4108T1M outer membrane protein x HVY57_RS21980 ENOG4108I6E Sulfatase HVY57_RS21990 ENOG4105KST dependent repressor HVY57_RS21995 ENOG4105F4P )-transporter HVY57_RS22000 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY57_RS22005 ENOG4105C5H ABC transporter HVY57_RS22010 ENOG4108HCJ Hydrolase HVY57_RS22020 ENOG4105F1A Pyruvate formate-lyase HVY57_RS22025 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY57_RS22030 ENOG4105D06 uba thif-type nad fad binding protein HVY57_RS22035 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVY57_RS22040 ENOG4108JQ6 ABC transporter HVY57_RS22045 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY57_RS22050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY57_RS22060 ENOG4105BZU Histidine kinase HVY57_RS22065 ENOG41064RH membrane protein YliF HVY57_RS22075 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVY57_RS22080 ENOG4105D8V Glucose sorbosone dehydrogenase HVY57_RS22085 ENOG4108TGY Glutathione S-transferase HVY57_RS22090 ENOG4105DZ1 carboxypeptidase HVY57_RS22095 ENOG4107FB0 transcriptional regulator DeoR family HVY57_RS22100 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVY57_RS22105 ENOG4107QF7 multi-drug HVY57_RS22115 ENOG4108HCJ Hydrolase HVY57_RS22120 ENOG4106UW1 Major Facilitator superfamily HVY57_RS22125 ENOG4108RFG Tetr family transcriptional regulator HVY57_RS22140 ENOG4105GWF inner membrane protein YbjM HVY57_RS22145 ENOG4108DBC nitroreductase HVY57_RS22155 ENOG4108RMJ sensory transduction regulator HVY57_RS22160 ENOG4107RUE extracellular solute-binding protein family 1 HVY57_RS22165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY57_RS22170 ENOG4105F38 ABC transporter, permease HVY57_RS22175 ENOG4105D38 putrescine abc transporter HVY57_RS22180 ENOG4105RBQ inner membrane protein ybjO HVY57_RS22190 ENOG4106TNF Periplasmic binding protein HVY57_RS22195 ENOG4105DMR ABC, transporter HVY57_RS22200 ENOG4105GBT ABC transporter HVY57_RS22205 ENOG4106PMH Extracellular solute-binding protein family 3 HVY57_RS22210 ENOG4105E5Z arginine transporter ATP-binding subunit HVY57_RS22215 ENOG41064MM (LipO)protein HVY57_RS22225 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY57_RS22230 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY57_RS22235 ENOG4105CGD Nad-dependent epimerase dehydratase HVY57_RS22240 ENOG4105C5W Aldolase HVY57_RS22245 ENOG4105C7K acetolactate synthase HVY57_RS22255 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY57_RS22265 ENOG4105DWU Membrane HVY57_RS22270 ENOG4105EQR Transposase IS116 IS110 IS902 HVY57_RS22275 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY57_RS22280 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVY57_RS22285 ENOG4108MJ5 VirK protein HVY57_RS22290 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVY57_RS22300 ENOG4105VEQ Cold shock protein HVY57_RS22310 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY57_RS22320 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVY57_RS22330 ENOG4108JJ8 (ABC) transporter HVY57_RS22335 ENOG4108JJ9 ABC, transporter HVY57_RS22340 ENOG4105C3M thioredoxin reductase HVY57_RS22350 ENOG4105CNU cell division protein FtsK HVY57_RS22360 ENOG4105D1H recombination factor protein RarA HVY57_RS22370 ENOG4105CHJ isochorismatase hydrolase HVY57_RS22380 ENOG4105E5D amino acid HVY57_RS22390 ENOG4105F1A Pyruvate formate-lyase HVY57_RS22395 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY57_RS22440 ENOG4106JVB Replication Protein HVY57_RS22585 ENOG4105C4R Atp-dependent dna helicase HVY57_RS22730 ENOG4108M24 von Willebrand factor, type A HVY57_RS22735 ENOG4108M24 von Willebrand factor, type A HVY57_RS22765 ENOG4105DAX Pfam:DUF2983 HVY57_RS22845 ENOG4105CAF HipA N-terminal domain protein HVY57_RS22865 ENOG4108R0M Aminoglycoside HVY57_RS22880 ENOG4105D6U Sodium Glutamate Symporter HVY57_RS22895 ENOG4108ZHR arsR family transcriptional regulator HVY57_RS22945 ENOG4108BUD transposase HVY57_RS22965 ENOG4108BUD transposase HVY57_RS22990 ENOG4108BUD transposase HVY57_RS23005 ENOG4108BUD transposase HVY57_RS23020 ENOG4105EMU Dehydrogenase HVY57_RS23025 ENOG4108BUD transposase HVY57_RS23070 ENOG4108BUD transposase HVY57_RS23140 ENOG410624V efflux system protein HVY57_RS23170 ENOG4105DR5 peptidase HVY57_RS23180 ENOG4105E3B Multicopper oxidase HVY57_RS23185 ENOG4105VR0 copper resistance HVY57_RS23190 ENOG4105JDN Copper resistance protein HVY57_RS23195 ENOG4108PG2 copper resistance HVY57_RS23200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY57_RS23205 ENOG4105GR3 Histidine kinase HVY57_RS23290 ENOG4108KTG Membrane protein, drug metabolite transporter HVY57_RS23370 ENOG4108BUD transposase HVY57_RS23400 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HVY57_RS23420 ENOG4105T95 Thiol disulfide interChange protein HVY57_RS23580 ENOG4108SER Transposase HVY57_RS23585 ENOG41074AV Hok/gef family HVY57_RS23755 ENOG4108BUD transposase HVY57_RS23780 ENOG410607W Transposase HVY57_RS23785 ENOG4106JVB Replication Protein HVY57_RS23805 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVY57_RS23815 ENOG4108BUD transposase HVY57_RS23830 ENOG4108BUD transposase HVY57_RS23840 ENOG4105K4U addiction module toxin, RelE StbE family HVY57_RS23850 ENOG410607W Transposase HVY57_RS23895 ENOG4105DFE Dna adenine methylase HVY57_RS23925 ENOG4106JVB Replication Protein HVY57_RS23955 ENOG4105DH7 May be involved in recombination (By similarity) HVY57_RS23960 ENOG4105DFE Dna adenine methylase HVY57_RS23990 ENOG4105CDU Replicative dna helicase HVY57_RS24055 ENOG4108R1E Serine threonine protein phosphatase 1 HVY57_RS24205 ENOG4105D7V transposase HVY57_RS24220 ENOG4108UUM single-stranded DNA-binding protein HVY57_RS24245 ENOG4105E3B Multicopper oxidase HVY57_RS24295 ENOG4108C33 Resolvase HVY57_RS24300 ENOG4108X9F tail fiber protein HVY57_RS24310 ENOG4105UZW Tail fiber assembly protein HVY57_RS24315 ENOG410685N tail fiber protein HVY57_RS24360 ENOG41066DY Membrane HVY57_RS24365 ENOG4108ZMA Outer membrane lipoprotein