locus-tag	class	description
HVY57_RS00020	COG4695	Portal protein
HVY57_RS00110	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY57_RS00115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY57_RS00170	COG1882	Formate acetyltransferase
HVY57_RS00175	COG2116	formate transmembrane transporter activity
HVY57_RS00180	COG1944	ATP diphosphatase activity
HVY57_RS00185	COG2323	membrane
HVY57_RS00205	COG0539	negative regulation of cytoplasmic translation
HVY57_RS00240	COG3214	Protein conserved in bacteria
HVY57_RS00255	COG3173	Aminoglycoside phosphotransferase
HVY57_RS00260	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY57_RS00265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVY57_RS00275	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVY57_RS00285	COG2989	Protein conserved in bacteria
HVY57_RS00290	COG3108	Peptidase M15
HVY57_RS00295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVY57_RS00300	COG1448	Aminotransferase
HVY57_RS00320	COG0308	aminopeptidase N
HVY57_RS00325	COG1116	anion transmembrane transporter activity
HVY57_RS00330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY57_RS00340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY57_RS00345	COG0431	NADPH-dependent FMN reductase
HVY57_RS00360	COG0633	Ferredoxin
HVY57_RS00360	COG3217	Mosc domain protein beta barrel domain protein
HVY57_RS00370	COG0488	(ABC) transporter
HVY57_RS00375	COG2995	paraquat-inducible protein a
HVY57_RS00380	COG3008	intermembrane lipid transfer
HVY57_RS00380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY57_RS00385	COG3009	Protein conserved in bacteria
HVY57_RS00390	COG3130	regulation of translation
HVY57_RS00400	COG1067	ATP-dependent peptidase activity
HVY57_RS00420	COG3070	regulator of competence-specific genes
HVY57_RS00425	COG1289	transmembrane transporter activity
HVY57_RS00430	COG3304	Inner membrane component domain
HVY57_RS00435	COG0210	DNA helicase
HVY57_RS00450	COG1832	CoA-binding protein
HVY57_RS00465	COG1254	Belongs to the acylphosphatase family
HVY57_RS00470	COG2920	part of a sulfur-relay system
HVY57_RS00475	COG0670	Belongs to the BI1 family
HVY57_RS00490	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY57_RS00495	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY57_RS00500	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVY57_RS00505	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY57_RS00510	COG1999	signal sequence binding
HVY57_RS00515	COG1773	rubredoxin
HVY57_RS00520	COG3012	SEC-C Motif Domain Protein
HVY57_RS00520	COG3318	Belongs to the UPF0149 family
HVY57_RS00525	COG0814	amino acid
HVY57_RS00535	COG1528	Iron-storage protein
HVY57_RS00545	COG1528	Iron-storage protein
HVY57_RS00595	COG5433	transposase activity
HVY57_RS00600	COG1879	ABC-type sugar transport system periplasmic component
HVY57_RS00605	COG1129	ABC transporter
HVY57_RS00610	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY57_RS00615	COG1877	trehalose-phosphatase activity
HVY57_RS00625	COG0589	response to stress
HVY57_RS00640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVY57_RS00650	COG0643	Histidine kinase
HVY57_RS00650	COG2198	Histidine kinase
HVY57_RS00685	COG0840	transmembrane signaling receptor activity
HVY57_RS00700	COG0745	RESPONSE REGULATOR receiver
HVY57_RS00730	COG0583	DNA-binding transcription factor activity
HVY57_RS00755	COG3729	General stress protein
HVY57_RS00760	COG1309	transcriptional regulator
HVY57_RS00765	COG2200	EAL domain
HVY57_RS00770	COG2199	diguanylate cyclase activity
HVY57_RS00780	COG1215	transferase activity, transferring glycosyl groups
HVY57_RS00785	COG0425	Belongs to the sulfur carrier protein TusA family
HVY57_RS00800	COG0366	Alpha amylase catalytic
HVY57_RS00855	COG2197	response regulator
HVY57_RS00865	COG2197	response regulator
HVY57_RS00900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY57_RS00920	COG1294	oxidase, subunit
HVY57_RS00935	COG2205	protein histidine kinase activity
HVY57_RS00935	COG2198	Histidine kinase
HVY57_RS00935	COG0784	Response regulator, receiver
HVY57_RS00940	COG1879	ABC-type sugar transport system periplasmic component
HVY57_RS00945	COG0745	RESPONSE REGULATOR receiver
HVY57_RS00950	COG3005	denitrification pathway
HVY57_RS00955	COG0243	molybdopterin cofactor binding
HVY57_RS00970	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVY57_RS00990	COG3102	Protein conserved in bacteria
HVY57_RS01010	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVY57_RS01015	COG1801	Protein of unknown function DUF72
HVY57_RS01020	COG1335	isochorismatase
HVY57_RS01030	COG0494	nUDIX hydrolase
HVY57_RS01035	COG0217	transcriptional regulatory protein
HVY57_RS01065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY57_RS01075	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVY57_RS01080	COG0739	heme binding
HVY57_RS01085	COG1560	Kdo2-lipid A biosynthetic process
HVY57_RS01090	COG0469	pyruvate kinase activity
HVY57_RS01095	COG1737	Transcriptional regulator
HVY57_RS01100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVY57_RS01105	COG0129	dihydroxy-acid dehydratase activity
HVY57_RS01110	COG0800	Aldolase
HVY57_RS01120	COG3141	response to X-ray
HVY57_RS01130	COG2979	Protein of unknown function (DUF533)
HVY57_RS01135	COG1770	oligopeptidase
HVY57_RS01140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY57_RS01145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY57_RS01155	COG2372	response to copper ion
HVY57_RS01160	COG1276	copper resistance
HVY57_RS01170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY57_RS01190	COG3008	intermembrane lipid transfer
HVY57_RS01195	COG2995	paraquat-inducible protein a
HVY57_RS01200	COG1956	GAF domain-containing protein
HVY57_RS01220	COG2814	Major facilitator Superfamily
HVY57_RS01225	COG1414	Transcriptional regulator
HVY57_RS01255	COG2226	methyltransferase
HVY57_RS01270	COG3716	PTS system mannose fructose sorbose family IID component
HVY57_RS01275	COG3715	PTS system
HVY57_RS01280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY57_RS01280	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS01285	COG1253	flavin adenine dinucleotide binding
HVY57_RS01290	COG2200	EAL domain
HVY57_RS01295	COG1760	l-serine dehydratase
HVY57_RS01305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY57_RS01325	COG0251	oxidation-reduction process
HVY57_RS01340	COG1199	ATP-dependent helicase activity
HVY57_RS01345	COG1214	PFAM Peptidase M22, glycoprotease
HVY57_RS01350	COG3065	identical protein binding
HVY57_RS01355	COG0318	PFAM AMP-dependent synthetase and ligase
HVY57_RS01360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVY57_RS01365	COG1388	LysM domain
HVY57_RS01365	COG1376	ErfK ybiS ycfS ynhG family protein
HVY57_RS01370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVY57_RS01375	COG4763	Acyl-transferase
HVY57_RS01380	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY57_RS01390	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY57_RS01400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVY57_RS01405	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY57_RS01415	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY57_RS01420	COG1177	transmembrane transport
HVY57_RS01455	COG3139	Protein of unknown function (DUF1315)
HVY57_RS01460	COG1335	isochorismatase
HVY57_RS01465	COG0252	asparaginase activity
HVY57_RS01475	COG0616	signal peptide processing
HVY57_RS01480	COG0778	Nitroreductase
HVY57_RS01490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY57_RS01510	COG0494	nUDIX hydrolase
HVY57_RS01515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY57_RS01520	COG2897	thiosulfate sulfurtransferase activity
HVY57_RS01525	COG4136	ATPase activity
HVY57_RS01530	COG4135	transport system, permease component
HVY57_RS01535	COG4134	Bacterial extracellular solute-binding protein
HVY57_RS01540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY57_RS01545	COG0398	Pfam SNARE associated Golgi protein
HVY57_RS01550	COG0398	Pfam SNARE associated Golgi protein
HVY57_RS01555	COG0708	Exodeoxyribonuclease III
HVY57_RS01585	COG3678	ATP-independent chaperone mediated protein folding
HVY57_RS01595	COG0322	excinuclease ABC activity
HVY57_RS01605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY57_RS01610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY57_RS01615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY57_RS01620	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY57_RS01625	COG2169	Transcriptional regulator
HVY57_RS01625	COG1917	Cupin 2, conserved barrel domain protein
HVY57_RS01635	COG1486	melibiose metabolic process
HVY57_RS01645	COG0753	catalase activity
HVY57_RS01660	COG1988	membrane-bound metal-dependent
HVY57_RS01665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY57_RS01675	COG3001	Fructosamine kinase
HVY57_RS01685	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY57_RS01690	COG3137	Salt-induced outer membrane protein
HVY57_RS01765	COG3429	Glucose-6-phosphate dehydrogenase subunit
HVY57_RS01765	COG3409	Peptidoglycan-binding domain 1 protein
HVY57_RS01810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY57_RS01820	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY57_RS01900	COG4695	Portal protein
HVY57_RS01910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HVY57_RS01970	COG4974	Belongs to the 'phage' integrase family
HVY57_RS01990	COG0791	NLP P60 protein
HVY57_RS02005	COG4256	Hemin uptake protein
HVY57_RS02010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY57_RS02020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY57_RS02020	COG0574	Belongs to the PEP-utilizing enzyme family
HVY57_RS02035	COG0628	permease
HVY57_RS02040	COG0247	lactate metabolic process
HVY57_RS02040	COG0277	FAD linked oxidase domain protein
HVY57_RS02045	COG2050	protein possibly involved in aromatic compounds catabolism
HVY57_RS02055	COG0316	Belongs to the HesB IscA family
HVY57_RS02060	COG0719	Fe-S assembly protein
HVY57_RS02065	COG0396	ATPase activity
HVY57_RS02070	COG0719	Fe-S assembly protein
HVY57_RS02085	COG1376	ErfK ybiS ycfS ynhG family protein
HVY57_RS02090	COG4238	major outer membrane lipoprotein
HVY57_RS02095	COG0469	pyruvate kinase activity
HVY57_RS02140	COG0307	riboflavin synthase, alpha
HVY57_RS02145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY57_RS02150	COG2814	Major facilitator Superfamily
HVY57_RS02155	COG0583	DNA-binding transcription factor activity
HVY57_RS02170	COG2814	Major facilitator Superfamily
HVY57_RS02175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY57_RS02180	COG0791	NLP P60 protein
HVY57_RS02185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVY57_RS02190	COG1201	RNA secondary structure unwinding
HVY57_RS02200	COG0346	lactoylglutathione lyase activity
HVY57_RS02205	COG1902	pentaerythritol trinitrate reductase activity
HVY57_RS02210	COG1309	transcriptional regulator
HVY57_RS02215	COG3313	Fe-S protein
HVY57_RS02220	COG4989	oxidoreductase activity
HVY57_RS02225	COG2032	superoxide dismutase activity
HVY57_RS02230	COG1289	transmembrane transporter activity
HVY57_RS02235	COG1566	PFAM secretion protein HlyD family protein
HVY57_RS02250	COG3133	Outer membrane lipoprotein
HVY57_RS02260	COG3895	Periplasmic Protein
HVY57_RS02280	COG0625	glutathione transferase activity
HVY57_RS02285	COG3104	oligopeptide transport
HVY57_RS02290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVY57_RS02300	COG4659	FMN binding
HVY57_RS02340	COG0673	inositol 2-dehydrogenase activity
HVY57_RS02350	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY57_RS02360	COG5339	Protein conserved in bacteria
HVY57_RS02365	COG1482	cell wall glycoprotein biosynthetic process
HVY57_RS02370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY57_RS02370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY57_RS02375	COG0114	fumarate hydratase activity
HVY57_RS02385	COG2205	protein histidine kinase activity
HVY57_RS02390	COG0745	RESPONSE REGULATOR receiver
HVY57_RS02395	COG3136	membrane protein required for alginate biosynthesis
HVY57_RS02405	COG0531	amino acid
HVY57_RS02415	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVY57_RS02420	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVY57_RS02430	COG3591	Belongs to the peptidase S1B family
HVY57_RS02445	COG2814	Major facilitator Superfamily
HVY57_RS02450	COG0583	DNA-binding transcription factor activity
HVY57_RS02455	COG1940	carbohydrate kinase activity
HVY57_RS02460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY57_RS02495	COG3238	Protein conserved in bacteria
HVY57_RS02500	COG1247	-acetyltransferase
HVY57_RS02505	COG2130	NADP-dependent
HVY57_RS02510	COG1802	Transcriptional regulator
HVY57_RS02515	COG4772	TonB-dependent receptor
HVY57_RS02520	COG3391	amine dehydrogenase activity
HVY57_RS02525	COG1113	amino acid transport
HVY57_RS02530	COG0625	glutathione transferase activity
HVY57_RS02535	COG5433	transposase activity
HVY57_RS02555	COG5433	transposase activity
HVY57_RS02580	COG0384	phenazine biosynthesis protein PhzF
HVY57_RS02590	COG1609	Transcriptional regulator
HVY57_RS02600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY57_RS02605	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVY57_RS02610	COG1414	Transcriptional regulator
HVY57_RS02615	COG4948	Mandelate Racemase Muconate Lactonizing
HVY57_RS02620	COG4829	muconolactone delta-isomerase
HVY57_RS02625	COG3485	protocatechuate 3,4-dioxygenase
HVY57_RS02660	COG0697	spore germination
HVY57_RS02670	COG0437	4 iron, 4 sulfur cluster binding
HVY57_RS02675	COG2864	formate dehydrogenase
HVY57_RS02680	COG3093	addiction module antidote protein HigA
HVY57_RS02690	COG1064	alcohol dehydrogenase
HVY57_RS02710	COG1764	response to oxidative stress
HVY57_RS02720	COG0583	DNA-binding transcription factor activity
HVY57_RS02725	COG3485	protocatechuate 3,4-dioxygenase
HVY57_RS02730	COG3485	protocatechuate 3,4-dioxygenase
HVY57_RS02735	COG5383	Protein conserved in bacteria
HVY57_RS02745	COG2841	Protein conserved in bacteria
HVY57_RS02750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY57_RS02755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY57_RS02760	COG0500	methyltransferase
HVY57_RS02770	COG0826	peptidase U32
HVY57_RS02785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY57_RS02790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY57_RS02795	COG3842	ATPase activity
HVY57_RS02800	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY57_RS02805	COG1177	transmembrane transport
HVY57_RS02835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY57_RS02850	COG4948	Mandelate Racemase Muconate Lactonizing
HVY57_RS02855	COG1063	alcohol dehydrogenase
HVY57_RS02860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY57_RS02870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY57_RS02880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY57_RS02885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY57_RS02885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY57_RS02895	COG0246	Mannitol dehydrogenase
HVY57_RS02905	COG1802	Transcriptional regulator
HVY57_RS02910	COG4221	oxidoreductase activity
HVY57_RS02915	COG0339	signal peptide processing
HVY57_RS02920	COG1546	Belongs to the CinA family
HVY57_RS02925	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY57_RS02930	COG3706	GGDEF domain
HVY57_RS02935	COG2814	Major facilitator Superfamily
HVY57_RS02940	COG0697	spore germination
HVY57_RS02950	COG4977	sequence-specific DNA binding
HVY57_RS02955	COG1846	Transcriptional regulator
HVY57_RS02970	COG0583	DNA-binding transcription factor activity
HVY57_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS02980	COG2066	Belongs to the glutaminase family
HVY57_RS02990	COG2199	diguanylate cyclase activity
HVY57_RS03000	COG3781	membrane
HVY57_RS03010	COG0675	Transposase, IS605 OrfB family
HVY57_RS03070	COG2826	transposase and inactivated derivatives, IS30 family
HVY57_RS03080	COG2207	Transcriptional regulator
HVY57_RS03100	COG4178	(ABC) transporter
HVY57_RS03105	COG4771	TonB-dependent receptor
HVY57_RS03110	COG0612	Peptidase, M16
HVY57_RS03115	COG0076	glutamate decarboxylase activity
HVY57_RS03120	COG0531	amino acid
HVY57_RS03135	COG3039	Transposase
HVY57_RS03145	COG2202	Pas domain
HVY57_RS03145	COG2200	EAL domain
HVY57_RS03145	COG2199	diguanylate cyclase activity
HVY57_RS03160	COG3038	cytochrome b561
HVY57_RS03165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVY57_RS03170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY57_RS03200	COG1643	Atp-dependent helicase
HVY57_RS03210	COG0671	phosphoesterase, PA-phosphatase related
HVY57_RS03210	COG2453	phosphatase
HVY57_RS03215	COG2267	carboxylic ester hydrolase activity
HVY57_RS03220	COG4589	Belongs to the CDS family
HVY57_RS03225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY57_RS03235	COG0667	Aldo Keto reductase
HVY57_RS03240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY57_RS03245	COG3327	negative regulation of DNA-templated transcription, initiation
HVY57_RS03250	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVY57_RS03255	COG0183	Belongs to the thiolase family
HVY57_RS03260	COG2050	protein possibly involved in aromatic compounds catabolism
HVY57_RS03265	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY57_RS03270	COG1024	Enoyl-CoA hydratase
HVY57_RS03275	COG1024	Enoyl-CoA hydratase
HVY57_RS03280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY57_RS03285	COG2151	metal-sulfur cluster biosynthetic enzyme
HVY57_RS03290	COG3396	Phenylacetate-CoA oxygenase
HVY57_RS03295	COG3460	Phenylacetate-CoA oxygenase
HVY57_RS03300	COG3396	Phenylacetate-CoA oxygenase
HVY57_RS03305	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS03305	COG2030	dehydratase
HVY57_RS03310	COG3733	amine oxidase
HVY57_RS03315	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS03320	COG2207	Transcriptional regulator
HVY57_RS03330	COG3784	Protein of unknown function (DUF1318)
HVY57_RS03340	COG2911	Protein conserved in bacteria
HVY57_RS03345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVY57_RS03350	COG3187	Heat shock protein
HVY57_RS03355	COG3042	response to heat
HVY57_RS03365	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVY57_RS03365	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVY57_RS03365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVY57_RS03365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY57_RS03370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY57_RS03375	COG0589	response to stress
HVY57_RS03385	COG0513	Belongs to the DEAD box helicase family
HVY57_RS03400	COG3706	GGDEF domain
HVY57_RS03405	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY57_RS03410	COG0596	Alpha beta hydrolase
HVY57_RS03420	COG0183	Belongs to the thiolase family
HVY57_RS03425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY57_RS03435	COG1414	Transcriptional regulator
HVY57_RS03440	COG2840	Smr protein MutS2
HVY57_RS03445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY57_RS03450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY57_RS03455	COG0589	response to stress
HVY57_RS03460	COG3182	Iron-regulated membrane protein
HVY57_RS03465	COG0668	transmembrane transport
HVY57_RS03470	COG4166	transmembrane transport
HVY57_RS03475	COG2866	Carboxypeptidase
HVY57_RS03480	COG4948	Mandelate Racemase Muconate Lactonizing
HVY57_RS03485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVY57_RS03490	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVY57_RS03500	COG3106	COG3106 Predicted ATPase
HVY57_RS03505	COG1609	Transcriptional regulator
HVY57_RS03515	COG3842	ATPase activity
HVY57_RS03520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY57_RS03530	COG0673	inositol 2-dehydrogenase activity
HVY57_RS03535	COG1082	Xylose isomerase domain protein TIM barrel
HVY57_RS03540	COG1063	alcohol dehydrogenase
HVY57_RS03545	COG0395	ABC-type sugar transport system, permease component
HVY57_RS03550	COG1175	transmembrane transport
HVY57_RS03555	COG1653	transport
HVY57_RS03560	COG0366	Alpha amylase catalytic
HVY57_RS03565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY57_RS03575	COG1983	PspC domain protein
HVY57_RS03585	COG1842	Phage shock protein A
HVY57_RS03590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY57_RS03595	COG4166	transmembrane transport
HVY57_RS03600	COG4168	peptide transport system, permease
HVY57_RS03605	COG4171	peptide transport system, permease
HVY57_RS03610	COG4172	Belongs to the ABC transporter superfamily
HVY57_RS03615	COG4172	Belongs to the ABC transporter superfamily
HVY57_RS03620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVY57_RS03625	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY57_RS03625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY57_RS03635	COG5001	Diguanylate cyclase
HVY57_RS03645	COG1349	DNA-binding transcription factor activity
HVY57_RS03655	COG0023	Translation Initiation Factor
HVY57_RS03665	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVY57_RS03670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVY57_RS03675	COG0671	phosphoesterase, PA-phosphatase related
HVY57_RS03705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY57_RS03715	COG0616	signal peptide processing
HVY57_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS03725	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVY57_RS03730	COG1187	pseudouridine synthase activity
HVY57_RS03735	COG4907	membrane protein (DUF2207)
HVY57_RS03740	COG0009	L-threonylcarbamoyladenylate synthase
HVY57_RS03745	COG0613	PHP domain protein
HVY57_RS03755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY57_RS03760	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY57_RS03760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY57_RS03765	COG0135	phosphoribosylanthranilate isomerase activity
HVY57_RS03765	COG0134	indole-3-glycerol-phosphate synthase activity
HVY57_RS03780	COG3047	cAMP biosynthetic process
HVY57_RS03785	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVY57_RS03800	COG1607	acyl-coa hydrolase
HVY57_RS03810	COG2350	Protein conserved in bacteria
HVY57_RS03830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY57_RS03835	COG4608	Belongs to the ABC transporter superfamily
HVY57_RS03840	COG0444	Belongs to the ABC transporter superfamily
HVY57_RS03860	COG2095	MarC family integral membrane protein
HVY57_RS03865	COG1454	alcohol dehydrogenase
HVY57_RS03865	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS03875	COG1435	thymidine kinase activity
HVY57_RS03885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY57_RS03890	COG0745	RESPONSE REGULATOR receiver
HVY57_RS03895	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVY57_RS03905	COG0788	formyltetrahydrofolate deformylase activity
HVY57_RS03950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY57_RS03955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVY57_RS03960	COG2181	nitrate reductase activity
HVY57_RS03965	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY57_RS03970	COG1140	nitrate reductase beta subunit
HVY57_RS03975	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY57_RS03980	COG2223	nitrite transmembrane transporter activity
HVY57_RS03985	COG3850	Histidine kinase
HVY57_RS03990	COG2197	response regulator
HVY57_RS03995	COG4932	domain protein
HVY57_RS04000	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVY57_RS04005	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVY57_RS04010	COG4572	Cation transport regulator
HVY57_RS04015	COG0387	Pfam Sodium calcium exchanger
HVY57_RS04035	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY57_RS04060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVY57_RS04065	COG0659	secondary active sulfate transmembrane transporter activity
HVY57_RS04080	COG0012	GTP binding
HVY57_RS04100	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVY57_RS04110	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVY57_RS04120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY57_RS04130	COG2719	SpoVR family
HVY57_RS04145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVY57_RS04170	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY57_RS04185	COG2894	cell division
HVY57_RS04195	COG1124	(ABC) transporter
HVY57_RS04205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY57_RS04210	COG0601	transmembrane transport
HVY57_RS04215	COG0747	negative chemotaxis
HVY57_RS04230	COG1473	amidohydrolase
HVY57_RS04240	COG0217	transcriptional regulatory protein
HVY57_RS04255	COG0538	isocitrate dehydrogenase activity
HVY57_RS04260	COG1187	pseudouridine synthase activity
HVY57_RS04280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVY57_RS04285	COG0745	RESPONSE REGULATOR receiver
HVY57_RS04290	COG2205	protein histidine kinase activity
HVY57_RS04295	COG2850	peptidyl-arginine hydroxylation
HVY57_RS04300	COG0656	L-ascorbic acid biosynthetic process
HVY57_RS04305	COG3713	MltA-interacting MipA family protein
HVY57_RS04310	COG2766	serine protein kinase
HVY57_RS04320	COG2199	diguanylate cyclase activity
HVY57_RS04325	COG2199	diguanylate cyclase activity
HVY57_RS04330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY57_RS04345	COG2807	transmembrane transport
HVY57_RS04350	COG3189	MarR family transcriptional regulator
HVY57_RS04355	COG3042	response to heat
HVY57_RS04360	COG2203	Gaf domain
HVY57_RS04360	COG2199	diguanylate cyclase activity
HVY57_RS04375	COG2261	transglycosylase associated protein
HVY57_RS04385	COG3134	Outer membrane lipoprotein
HVY57_RS04390	COG1252	NADH dehydrogenase
HVY57_RS04405	COG0510	thiamine kinase activity
HVY57_RS04410	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVY57_RS04415	COG5633	Lipoprotein
HVY57_RS04420	COG0537	adenosine 5'-monophosphoramidase activity
HVY57_RS04430	COG0084	hydrolase, TatD family'
HVY57_RS04435	COG0470	DNA polymerase III
HVY57_RS04445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVY57_RS04450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY57_RS04455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY57_RS04465	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS04470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVY57_RS04490	COG1399	metal-binding, possibly nucleic acid-binding protein
HVY57_RS04495	COG0424	maF-like protein
HVY57_RS04500	COG0564	pseudouridine synthase activity
HVY57_RS04505	COG1530	ribonuclease E activity
HVY57_RS04510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVY57_RS04515	COG1256	bacterial-type flagellum assembly
HVY57_RS04520	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVY57_RS04520	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVY57_RS04540	COG4787	bacterial-type flagellum-dependent cell motility
HVY57_RS04545	COG1749	Flagellar hook protein flgE
HVY57_RS04550	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVY57_RS04555	COG1558	bacterial-type flagellum-dependent cell motility
HVY57_RS04570	COG2747	anti-sigma28 factor FlgM
HVY57_RS04580	COG0728	peptidoglycan biosynthetic process
HVY57_RS04585	COG0673	inositol 2-dehydrogenase activity
HVY57_RS04595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY57_RS04630	COG3038	cytochrome b561
HVY57_RS04635	COG2353	YceI-like domain
HVY57_RS04645	COG1560	Kdo2-lipid A biosynthetic process
HVY57_RS04660	COG5645	(Lipo)protein
HVY57_RS04665	COG2943	transferase activity, transferring hexosyl groups
HVY57_RS04680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY57_RS04725	COG1462	curli production assembly transport component CsgG
HVY57_RS04735	COG3381	protein complex oligomerization
HVY57_RS04790	COG2003	Belongs to the UPF0758 family
HVY57_RS04805	COG3468	outer membrane autotransporter barrel domain protein
HVY57_RS04830	COG3039	Transposase
HVY57_RS04840	COG1556	Lactate utilization protein
HVY57_RS04845	COG1139	Iron-sulfur cluster binding protein
HVY57_RS04850	COG0247	lactate metabolic process
HVY57_RS04855	COG0277	FAD linked oxidase domain protein
HVY57_RS04860	COG1620	l-lactate permease
HVY57_RS04875	COG2207	Transcriptional regulator
HVY57_RS04880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY57_RS04890	COG3059	membrane
HVY57_RS04900	COG3708	Transcriptional regulator
HVY57_RS04900	COG2207	Transcriptional regulator
HVY57_RS04945	COG0582	viral genome integration into host DNA
HVY57_RS04950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVY57_RS04955	COG3104	oligopeptide transport
HVY57_RS04960	COG1982	Orn Lys Arg decarboxylase major
HVY57_RS04965	COG0531	amino acid
HVY57_RS04970	COG3710	Transcriptional regulator
HVY57_RS04975	COG3706	GGDEF domain
HVY57_RS04980	COG0457	Tetratricopeptide repeat
HVY57_RS04985	COG1649	PFAM Uncharacterised BCR, COG1649
HVY57_RS04985	COG0726	polysaccharide deacetylase
HVY57_RS04990	COG1215	transferase activity, transferring glycosyl groups
HVY57_RS04995	COG3658	cytochrome
HVY57_RS05000	COG1702	phosphate starvation-inducible protein PhoH
HVY57_RS05010	COG2822	iron ion transport
HVY57_RS05020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY57_RS05030	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY57_RS05030	COG0506	proline dehydrogenase activity
HVY57_RS05030	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY57_RS05035	COG1560	Kdo2-lipid A biosynthetic process
HVY57_RS05040	COG2990	Protein conserved in bacteria
HVY57_RS05050	COG0726	polysaccharide deacetylase
HVY57_RS05055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVY57_RS05060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVY57_RS05065	COG3344	reverse transcriptase
HVY57_RS05075	COG1766	The M ring may be actively involved in energy transduction
HVY57_RS05080	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY57_RS05085	COG1317	bacterial-type flagellum organization
HVY57_RS05090	COG1157	protein secretion by the type III secretion system
HVY57_RS05095	COG2882	bacterial-type flagellum organization
HVY57_RS05100	COG3144	bacterial-type flagellum assembly
HVY57_RS05105	COG1580	Controls the rotational direction of flagella during chemotaxis
HVY57_RS05110	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY57_RS05115	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY57_RS05120	COG3190	flagellar
HVY57_RS05125	COG1338	Plays a role in the flagellum-specific transport system
HVY57_RS05140	COG2197	response regulator
HVY57_RS05165	COG5475	Uncharacterized small protein (DUF2158)
HVY57_RS05170	COG2354	Protein conserved in bacteria
HVY57_RS05175	COG0697	spore germination
HVY57_RS05180	COG3727	T/G mismatch-specific endonuclease activity
HVY57_RS05185	COG1418	mRNA catabolic process
HVY57_RS05195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY57_RS05205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY57_RS05230	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY57_RS05320	COG4695	Portal protein
HVY57_RS05355	COG3179	chitinase
HVY57_RS05380	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVY57_RS05385	COG1403	HNH endonuclease
HVY57_RS05405	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVY57_RS05430	COG1396	sequence-specific DNA binding
HVY57_RS05470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY57_RS05500	COG0583	DNA-binding transcription factor activity
HVY57_RS05545	COG3157	Type VI secretion system effector, Hcp
HVY57_RS05605	COG5433	transposase activity
HVY57_RS05625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVY57_RS05630	COG0477	Major facilitator Superfamily
HVY57_RS05640	COG0534	Mate efflux family protein
HVY57_RS05680	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS05680	COG1454	alcohol dehydrogenase
HVY57_RS05690	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS05690	COG1454	alcohol dehydrogenase
HVY57_RS05695	COG1882	Formate acetyltransferase
HVY57_RS05700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY57_RS05710	COG4869	propanediol catabolic process
HVY57_RS05730	COG1376	ErfK ybiS ycfS ynhG family protein
HVY57_RS05830	COG4656	Part of a membrane complex involved in electron transport
HVY57_RS05860	COG1289	transmembrane transporter activity
HVY57_RS05890	COG2925	Exonuclease
HVY57_RS05895	COG0425	Belongs to the sulfur carrier protein TusA family
HVY57_RS05900	COG2391	methyltransferase activity
HVY57_RS05905	COG0531	amino acid
HVY57_RS05915	COG0583	DNA-binding transcription factor activity
HVY57_RS05920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY57_RS05925	COG4115	mRNA cleavage
HVY57_RS05930	COG2161	toxin-antitoxin pair type II binding
HVY57_RS05945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVY57_RS05955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY57_RS05955	COG0131	Imidazoleglycerol-phosphate dehydratase
HVY57_RS05960	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVY57_RS05990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVY57_RS05995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVY57_RS06000	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVY57_RS06000	COG0662	Cupin 2, conserved barrel domain protein
HVY57_RS06040	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY57_RS06055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY57_RS06065	COG0438	transferase activity, transferring glycosyl groups
HVY57_RS06070	COG2327	Polysaccharide pyruvyl transferase
HVY57_RS06075	COG2244	polysaccharide biosynthetic process
HVY57_RS06080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVY57_RS06085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVY57_RS06090	COG0662	Cupin 2, conserved barrel domain protein
HVY57_RS06090	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVY57_RS06095	COG0297	glycogen (starch) synthase activity
HVY57_RS06100	COG1051	belongs to the nudix hydrolase family
HVY57_RS06105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY57_RS06110	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVY57_RS06115	COG0110	maltose O-acetyltransferase activity
HVY57_RS06120	COG1216	Glycosyl transferase, family 2
HVY57_RS06130	COG0438	transferase activity, transferring glycosyl groups
HVY57_RS06135	COG1045	serine acetyltransferase
HVY57_RS06140	COG0463	Glycosyl transferase, family 2
HVY57_RS06145	COG0489	protein tyrosine kinase activity
HVY57_RS06145	COG3206	protein involved in exopolysaccharide biosynthesis
HVY57_RS06150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVY57_RS06155	COG1596	polysaccharide export
HVY57_RS06160	COG1253	flavin adenine dinucleotide binding
HVY57_RS06170	COG2982	Protein involved in outer membrane biogenesis
HVY57_RS06185	COG5001	Diguanylate cyclase
HVY57_RS06185	COG3447	MASE1 domain protein
HVY57_RS06185	COG5002	protein histidine kinase activity
HVY57_RS06190	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVY57_RS06195	COG0443	Heat shock 70 kDa protein
HVY57_RS06200	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVY57_RS06205	COG3779	Protein conserved in bacteria
HVY57_RS06210	COG0631	protein serine/threonine phosphatase activity
HVY57_RS06215	COG4245	von Willebrand factor, type A
HVY57_RS06250	COG2205	protein histidine kinase activity
HVY57_RS06255	COG0745	RESPONSE REGULATOR receiver
HVY57_RS06265	COG3609	addiction module antidote protein, CC2985 family
HVY57_RS06285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY57_RS06295	COG1070	Carbohydrate kinase
HVY57_RS06320	COG1069	ribulokinase activity
HVY57_RS06330	COG1830	Aldolase
HVY57_RS06335	COG2211	Major facilitator Superfamily
HVY57_RS06340	COG1397	ADP-ribosylglycohydrolase
HVY57_RS06345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY57_RS06350	COG2188	Transcriptional regulator
HVY57_RS06360	COG0351	phosphomethylpyrimidine kinase
HVY57_RS06370	COG5455	response to cobalt ion
HVY57_RS06375	COG3539	Fimbrial protein
HVY57_RS06380	COG3188	usher protein
HVY57_RS06385	COG3121	Chaperone
HVY57_RS06400	COG0489	protein tyrosine kinase activity
HVY57_RS06410	COG3831	ATPase activity
HVY57_RS06415	COG3831	ATPase activity
HVY57_RS06420	COG3831	ATPase activity
HVY57_RS06425	COG3831	ATPase activity
HVY57_RS06435	COG0714	Associated with various cellular activities
HVY57_RS06440	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVY57_RS06445	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVY57_RS06450	COG4715	Zinc finger, swim domain protein
HVY57_RS06455	COG4808	Protein conserved in bacteria
HVY57_RS06460	COG4807	Protein conserved in bacteria
HVY57_RS06470	COG3275	phosphorelay sensor kinase activity
HVY57_RS06475	COG0789	Transcriptional regulator
HVY57_RS06485	COG1174	glycine betaine transport
HVY57_RS06490	COG1125	glycine betaine transport
HVY57_RS06495	COG1174	glycine betaine transport
HVY57_RS06500	COG1732	Glycine betaine
HVY57_RS06505	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY57_RS06510	COG0277	FAD linked oxidase domain protein
HVY57_RS06515	COG1686	Belongs to the peptidase S11 family
HVY57_RS06525	COG0586	Pfam SNARE associated Golgi protein
HVY57_RS06530	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS06540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY57_RS06550	COG1346	cytolysis
HVY57_RS06560	COG2949	membrane
HVY57_RS06570	COG0493	'glutamate synthase
HVY57_RS06575	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVY57_RS06575	COG0167	dihydroorotate dehydrogenase activity
HVY57_RS06585	COG1129	ABC transporter
HVY57_RS06590	COG1879	ABC-type sugar transport system periplasmic component
HVY57_RS06595	COG1609	Transcriptional regulator
HVY57_RS06600	COG2311	Membrane
HVY57_RS06615	COG4771	TonB-dependent receptor
HVY57_RS06620	COG0833	amino acid
HVY57_RS06625	COG0583	DNA-binding transcription factor activity
HVY57_RS06630	COG2855	membrane
HVY57_RS06640	COG1522	sequence-specific DNA binding
HVY57_RS06640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY57_RS06645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY57_RS06655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY57_RS06660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY57_RS06665	COG2313	pseudouridylate synthase activity
HVY57_RS06670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY57_RS06675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS06675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS06675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVY57_RS06680	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY57_RS06685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS06685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS06705	COG0246	Mannitol dehydrogenase
HVY57_RS06710	COG0523	cobalamin synthesis protein
HVY57_RS06715	COG0671	phosphoesterase, PA-phosphatase related
HVY57_RS06720	COG0791	NLP P60 protein
HVY57_RS06725	COG2200	EAL domain
HVY57_RS06730	COG4166	transmembrane transport
HVY57_RS06735	COG4174	ABC transporter (Permease)
HVY57_RS06740	COG4239	(ABC) transporter, permease
HVY57_RS06745	COG4172	Belongs to the ABC transporter superfamily
HVY57_RS06755	COG2814	Major facilitator Superfamily
HVY57_RS06760	COG1187	pseudouridine synthase activity
HVY57_RS06765	COG1061	Type III restriction enzyme res subunit
HVY57_RS06775	COG0596	Alpha beta hydrolase
HVY57_RS06790	COG3083	sulfuric ester hydrolase activity
HVY57_RS06810	COG2197	response regulator
HVY57_RS06815	COG3088	subunit of a heme lyase
HVY57_RS06815	COG4235	cytochrome complex assembly
HVY57_RS06820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY57_RS06825	COG1138	Cytochrome C-type biogenesis protein
HVY57_RS06835	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY57_RS06840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY57_RS06845	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY57_RS06850	COG4133	protoheme IX ABC transporter activity
HVY57_RS06855	COG3005	denitrification pathway
HVY57_RS06860	COG3043	anaerobic respiration
HVY57_RS06865	COG0348	domain, Protein
HVY57_RS06870	COG0437	4 iron, 4 sulfur cluster binding
HVY57_RS06880	COG3062	negative regulation of establishment of protein localization
HVY57_RS06885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY57_RS06885	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY57_RS06895	COG0668	transmembrane transport
HVY57_RS06910	COG4774	siderophore transport
HVY57_RS06920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY57_RS06930	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY57_RS06935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY57_RS06940	COG1199	ATP-dependent helicase activity
HVY57_RS06945	COG0513	Belongs to the DEAD box helicase family
HVY57_RS06950	COG1309	transcriptional regulator
HVY57_RS06960	COG1131	(ABC) transporter
HVY57_RS06965	COG0842	Transport permease protein
HVY57_RS06970	COG0842	Transport permease protein
HVY57_RS06980	COG3568	Endonuclease Exonuclease Phosphatase
HVY57_RS06985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY57_RS06990	COG0392	lysyltransferase activity
HVY57_RS07005	COG0670	Belongs to the BI1 family
HVY57_RS07010	COG2194	sulfuric ester hydrolase activity
HVY57_RS07015	COG0670	Belongs to the BI1 family
HVY57_RS07020	COG0314	molybdopterin synthase activity
HVY57_RS07025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVY57_RS07035	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY57_RS07045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVY57_RS07055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY57_RS07060	COG2226	methyltransferase
HVY57_RS07075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVY57_RS07080	COG1881	PFAM PEBP family protein
HVY57_RS07085	COG4677	pectinesterase activity
HVY57_RS07115	COG3328	transposase activity
HVY57_RS07120	COG0561	phosphatase activity
HVY57_RS07130	COG4149	molybdate abc transporter
HVY57_RS07135	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVY57_RS07145	COG2005	Transcriptional regulator
HVY57_RS07145	COG3585	molybdate ion transport
HVY57_RS07150	COG1119	ATPase activity
HVY57_RS07155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVY57_RS07160	COG1085	galactose-1-phosphate uridylyltransferase
HVY57_RS07170	COG2017	converts alpha-aldose to the beta-anomer
HVY57_RS07180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY57_RS07190	COG1230	cation diffusion facilitator family transporter
HVY57_RS07195	COG3201	nicotinamide mononucleotide transporter
HVY57_RS07245	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVY57_RS07250	COG2885	chlorophyll binding
HVY57_RS07260	COG3064	Membrane
HVY57_RS07265	COG0848	biopolymer transport protein
HVY57_RS07270	COG0811	peptide transport
HVY57_RS07275	COG0824	Thioesterase
HVY57_RS07280	COG3790	cyd operon protein YbgE
HVY57_RS07285	COG4890	Cyd operon protein YbgT
HVY57_RS07290	COG1294	oxidase, subunit
HVY57_RS07295	COG1271	oxidase subunit
HVY57_RS07300	COG0383	alpha-mannosidase activity
HVY57_RS07305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS07305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS07305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS07310	COG2188	Transcriptional regulator
HVY57_RS07315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY57_RS07325	COG4865	methylaspartate mutase activity
HVY57_RS07330	COG3799	methylaspartate ammonia-lyase activity
HVY57_RS07345	COG1301	dicarboxylic acid transport
HVY57_RS07350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY57_RS07350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY57_RS07355	COG0583	DNA-binding transcription factor activity
HVY57_RS07360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY57_RS07370	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY57_RS07375	COG0567	Dehydrogenase, E1 component
HVY57_RS07380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY57_RS07385	COG1053	succinate dehydrogenase
HVY57_RS07390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVY57_RS07395	COG2009	succinate dehydrogenase
HVY57_RS07400	COG0372	Belongs to the citrate synthase family
HVY57_RS07405	COG3539	Fimbrial protein
HVY57_RS07410	COG3188	usher protein
HVY57_RS07415	COG3121	Chaperone
HVY57_RS07420	COG3539	Fimbrial protein
HVY57_RS07425	COG3180	Ammonia monooxygenase
HVY57_RS07450	COG1984	allophanate hydrolase subunit 2
HVY57_RS07455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVY57_RS07460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVY57_RS07470	COG0415	Belongs to the DNA photolyase family
HVY57_RS07475	COG3272	Protein of unknown function (DUF1722)
HVY57_RS07505	COG2205	protein histidine kinase activity
HVY57_RS07510	COG0745	RESPONSE REGULATOR receiver
HVY57_RS07515	COG1982	Orn Lys Arg decarboxylase major
HVY57_RS07520	COG0531	amino acid
HVY57_RS07525	COG0033	Phosphoglucomutase
HVY57_RS07530	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVY57_RS07535	COG0596	Alpha beta hydrolase
HVY57_RS07545	COG0716	FMN binding
HVY57_RS07555	COG0735	belongs to the Fur family
HVY57_RS07575	COG2190	(PTS) system
HVY57_RS07575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY57_RS07575	COG1263	PTS System
HVY57_RS07585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY57_RS07590	COG1846	Transcriptional regulator
HVY57_RS07590	COG1940	carbohydrate kinase activity
HVY57_RS07595	COG0647	UMP catabolic process
HVY57_RS07600	COG0367	asparagine synthase
HVY57_RS07650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY57_RS07660	COG1702	phosphate starvation-inducible protein PhoH
HVY57_RS07670	COG4535	Mg2 and Co2 transporter CorC
HVY57_RS07675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVY57_RS07685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY57_RS07690	COG0765	amino acid transport
HVY57_RS07695	COG0765	amino acid transport
HVY57_RS07700	COG1126	abc transporter atp-binding protein
HVY57_RS07720	COG2888	peptidyl-tyrosine sulfation
HVY57_RS07735	COG1466	dna polymerase III delta subunit
HVY57_RS07745	COG0799	negative regulation of ribosome biogenesis
HVY57_RS07755	COG0768	penicillin binding
HVY57_RS07760	COG0772	Belongs to the SEDS family
HVY57_RS07765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY57_RS07770	COG1686	Belongs to the peptidase S11 family
HVY57_RS07795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY57_RS07815	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY57_RS07820	COG3719	Belongs to the RNase T2 family
HVY57_RS07825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY57_RS07830	COG0589	response to stress
HVY57_RS07835	COG3634	alkyl hydroperoxide reductase activity
HVY57_RS07840	COG0450	alkyl hydroperoxide reductase
HVY57_RS07850	COG0583	DNA-binding transcription factor activity
HVY57_RS07855	COG3969	phosphoadenosine phosphosulfate
HVY57_RS07860	COG1475	DNA binding
HVY57_RS07865	COG0436	Aminotransferase
HVY57_RS07870	COG0371	Dehydrogenase
HVY57_RS07875	COG2879	small protein
HVY57_RS07880	COG1966	Carbon starvation protein
HVY57_RS07885	COG2050	protein possibly involved in aromatic compounds catabolism
HVY57_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS07895	COG1535	isochorismatase
HVY57_RS07895	COG3433	isochorismatase activity
HVY57_RS07900	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVY57_RS07905	COG1169	isochorismate synthase
HVY57_RS07910	COG4592	Periplasmic binding protein
HVY57_RS07920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY57_RS07925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY57_RS07930	COG1120	ATPase activity
HVY57_RS07935	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY57_RS07940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVY57_RS07940	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVY57_RS07945	COG3251	PFAM MbtH domain protein
HVY57_RS07950	COG2382	esterase
HVY57_RS07955	COG4771	TonB-dependent receptor
HVY57_RS07960	COG2977	Belongs to the P-Pant transferase superfamily
HVY57_RS07965	COG3958	Transketolase
HVY57_RS07970	COG3959	Transketolase, thiamine diphosphate binding domain
HVY57_RS07975	COG2390	Transcriptional regulator
HVY57_RS07980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HVY57_RS07985	COG1879	ABC-type sugar transport system periplasmic component
HVY57_RS08000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY57_RS08010	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS08015	COG3385	transposase activity
HVY57_RS08025	COG3385	transposase activity
HVY57_RS08045	COG2315	Protein conserved in bacteria
HVY57_RS08050	COG0778	Nitroreductase
HVY57_RS08055	COG0668	transmembrane transport
HVY57_RS08060	COG1113	amino acid transport
HVY57_RS08065	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY57_RS08070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY57_RS08075	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY57_RS08080	COG1538	Outer membrane efflux protein
HVY57_RS08085	COG0745	RESPONSE REGULATOR receiver
HVY57_RS08090	COG5002	protein histidine kinase activity
HVY57_RS08095	COG5433	transposase activity
HVY57_RS08130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVY57_RS08140	COG2832	Protein of unknown function (DUF454)
HVY57_RS08145	COG3923	Primosomal replication protein n
HVY57_RS08155	COG1196	nuclear chromosome segregation
HVY57_RS08155	COG3264	Mechanosensitive ion channel
HVY57_RS08160	COG1309	transcriptional regulator
HVY57_RS08165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY57_RS08170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY57_RS08190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY57_RS08195	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVY57_RS08205	COG3695	enzyme binding
HVY57_RS08210	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVY57_RS08215	COG1946	Acyl-CoA thioesterase
HVY57_RS08220	COG0004	ammonium transporteR
HVY57_RS08225	COG0347	Belongs to the P(II) protein family
HVY57_RS08230	COG1132	(ABC) transporter
HVY57_RS08235	COG1132	(ABC) transporter
HVY57_RS08240	COG1522	sequence-specific DNA binding
HVY57_RS08250	COG4533	DNA binding
HVY57_RS08260	COG0824	Thioesterase
HVY57_RS08265	COG1555	photosystem II stabilization
HVY57_RS08270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY57_RS08275	COG0776	regulation of translation
HVY57_RS08280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVY57_RS08300	COG0271	Belongs to the BolA IbaG family
HVY57_RS08305	COG3056	Lipoprotein
HVY57_RS08310	COG2223	nitrite transmembrane transporter activity
HVY57_RS08315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVY57_RS08320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVY57_RS08325	COG1845	cytochrome c oxidase, subunit III
HVY57_RS08330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVY57_RS08350	COG1414	Transcriptional regulator
HVY57_RS08355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVY57_RS08385	COG2814	Major facilitator Superfamily
HVY57_RS08395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVY57_RS08400	COG0693	protein deglycase activity
HVY57_RS08415	COG0142	geranyltranstransferase activity
HVY57_RS08425	COG0667	Aldo Keto reductase
HVY57_RS08430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVY57_RS08450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY57_RS08450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY57_RS08460	COG4238	major outer membrane lipoprotein
HVY57_RS08465	COG3248	Nucleoside-binding outer membrane protein
HVY57_RS08475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY57_RS08480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY57_RS08485	COG1862	Preprotein translocase
HVY57_RS08505	COG0366	Alpha amylase catalytic
HVY57_RS08510	COG1113	amino acid transport
HVY57_RS08515	COG1114	Component of the transport system for branched-chain amino acids
HVY57_RS08520	COG5002	protein histidine kinase activity
HVY57_RS08530	COG0420	3'-5' exonuclease activity
HVY57_RS08535	COG0419	ATPase involved in DNA repair
HVY57_RS08540	COG1940	carbohydrate kinase activity
HVY57_RS08555	COG4126	flavin adenine dinucleotide binding
HVY57_RS08575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVY57_RS08580	COG3706	GGDEF domain
HVY57_RS08600	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY57_RS08620	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVY57_RS08625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY57_RS08630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY57_RS08640	COG0113	porphobilinogen synthase activity
HVY57_RS08645	COG2175	clavaminate synthase activity
HVY57_RS08650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY57_RS08660	COG4521	taurine ABC transporter
HVY57_RS08675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY57_RS08680	COG2079	MmgE PrpD family protein
HVY57_RS08685	COG0372	Belongs to the citrate synthase family
HVY57_RS08690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVY57_RS08695	COG3829	transcription factor binding
HVY57_RS08705	COG1280	lysine exporter protein (LysE YggA)
HVY57_RS08710	COG3706	GGDEF domain
HVY57_RS08715	COG2186	Transcriptional regulator
HVY57_RS08720	COG1063	alcohol dehydrogenase
HVY57_RS08725	COG2271	Major facilitator Superfamily
HVY57_RS08730	COG2200	EAL domain
HVY57_RS08740	COG2200	EAL domain
HVY57_RS08740	COG2771	luxR family
HVY57_RS08745	COG0454	-acetyltransferase
HVY57_RS08750	COG0656	L-ascorbic acid biosynthetic process
HVY57_RS08755	COG0667	Aldo Keto reductase
HVY57_RS08850	COG0582	viral genome integration into host DNA
HVY57_RS08895	COG2003	Belongs to the UPF0758 family
HVY57_RS08910	COG3468	outer membrane autotransporter barrel domain protein
HVY57_RS08945	COG3708	Transcriptional regulator
HVY57_RS08945	COG2207	Transcriptional regulator
HVY57_RS08955	COG3059	membrane
HVY57_RS08965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY57_RS08970	COG2207	Transcriptional regulator
HVY57_RS08975	COG0247	lactate metabolic process
HVY57_RS08980	COG1139	Iron-sulfur cluster binding protein
HVY57_RS08985	COG1556	Lactate utilization protein
HVY57_RS09025	COG4983	Phage plasmid primase, P4 family domain protein
HVY57_RS09030	COG4983	Phage plasmid primase, P4 family domain protein
HVY57_RS09065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY57_RS09085	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVY57_RS09090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY57_RS09095	COG1690	Belongs to the RtcB family
HVY57_RS09100	COG0454	-acetyltransferase
HVY57_RS09120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY57_RS09125	COG1074	ATP-dependent DNA helicase activity
HVY57_RS09130	COG1025	Belongs to the peptidase M16 family
HVY57_RS09135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVY57_RS09140	COG4967	type IV pilus modification protein PilV
HVY57_RS09150	COG4795	General secretion pathway protein
HVY57_RS09155	COG2165	general secretion pathway protein
HVY57_RS09185	COG0861	Integral membrane protein TerC family
HVY57_RS09195	COG0667	Aldo Keto reductase
HVY57_RS09220	COG1609	Transcriptional regulator
HVY57_RS09230	COG0583	DNA-binding transcription factor activity
HVY57_RS09235	COG0183	Belongs to the thiolase family
HVY57_RS09240	COG0814	amino acid
HVY57_RS09245	COG2771	luxR family
HVY57_RS09250	COG3710	Transcriptional regulator
HVY57_RS09260	COG1215	transferase activity, transferring glycosyl groups
HVY57_RS09265	COG4783	chaperone-mediated protein folding
HVY57_RS09275	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY57_RS09280	COG0402	S-adenosylhomocysteine deaminase activity
HVY57_RS09290	COG4942	peptidase
HVY57_RS09295	COG0235	Class ii aldolase
HVY57_RS09310	COG1126	abc transporter atp-binding protein
HVY57_RS09315	COG0583	DNA-binding transcription factor activity
HVY57_RS09320	COG2072	flavoprotein involved in K transport
HVY57_RS09335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY57_RS09340	COG0076	glutamate decarboxylase activity
HVY57_RS09345	COG2066	Belongs to the glutaminase family
HVY57_RS09350	COG2080	2 iron, 2 sulfur cluster binding
HVY57_RS09355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVY57_RS09360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVY57_RS09365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVY57_RS09380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVY57_RS09390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVY57_RS09395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY57_RS09400	COG4974	Belongs to the 'phage' integrase family
HVY57_RS09405	COG0716	FMN binding
HVY57_RS09415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVY57_RS09425	COG1272	protein, Hemolysin III
HVY57_RS09435	COG2723	6-phospho-beta-galactosidase activity
HVY57_RS09465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY57_RS09470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY57_RS09475	COG0006	proline dipeptidase activity
HVY57_RS09495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVY57_RS09505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY57_RS09520	COG2968	Membrane
HVY57_RS09525	COG1279	arginine transmembrane transporter activity
HVY57_RS09530	COG0668	transmembrane transport
HVY57_RS09535	COG0191	fructose-bisphosphate aldolase activity
HVY57_RS09550	COG1072	(Pantothenic acid kinase))
HVY57_RS09560	COG1494	fructose-1,6-bisphosphatase
HVY57_RS09565	COG1063	alcohol dehydrogenase
HVY57_RS09570	COG2213	PTS system mannitol-specific
HVY57_RS09575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS09580	COG0330	HflC and HflK could
HVY57_RS09585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY57_RS09590	COG0501	Belongs to the peptidase M48B family
HVY57_RS09610	COG1166	arginine decarboxylase activity
HVY57_RS09630	COG2814	Major facilitator Superfamily
HVY57_RS09640	COG2356	endonuclease I
HVY57_RS09645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVY57_RS09650	COG0189	ligase activity
HVY57_RS09665	COG2805	Type II/IV secretion system protein
HVY57_RS09670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVY57_RS09675	COG0762	integral membrane protein
HVY57_RS09685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HVY57_RS09690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY57_RS09695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY57_RS09700	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY57_RS09715	COG0252	asparaginase activity
HVY57_RS09725	COG3171	Protein conserved in bacteria
HVY57_RS09735	COG1194	a g-specific adenine glycosylase
HVY57_RS09750	COG2211	Major facilitator Superfamily
HVY57_RS09755	COG1982	Orn Lys Arg decarboxylase major
HVY57_RS09760	COG1811	Na channel or pump
HVY57_RS09770	COG3039	Transposase
HVY57_RS09815	COG4974	Belongs to the 'phage' integrase family
HVY57_RS09855	COG4735	regulation of single-species biofilm formation
HVY57_RS09860	COG2378	regulation of single-species biofilm formation
HVY57_RS09910	COG0582	viral genome integration into host DNA
HVY57_RS09930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY57_RS09935	COG1459	type II secretion system
HVY57_RS09940	COG2165	general secretion pathway protein
HVY57_RS09955	COG4795	General secretion pathway protein
HVY57_RS09970	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HVY57_RS10005	COG0754	glutathionylspermidine amidase activity
HVY57_RS10010	COG2207	Transcriptional regulator
HVY57_RS10015	COG0625	glutathione transferase activity
HVY57_RS10020	COG0298	carbon dioxide binding
HVY57_RS10030	COG1773	rubredoxin
HVY57_RS10035	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY57_RS10040	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY57_RS10045	COG5557	Pfam Polysulphide reductase, NrfD
HVY57_RS10050	COG0437	4 iron, 4 sulfur cluster binding
HVY57_RS10055	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY57_RS10070	COG0667	Aldo Keto reductase
HVY57_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS10085	COG0848	biopolymer transport protein
HVY57_RS10090	COG0811	peptide transport
HVY57_RS10095	COG0626	cystathionine gamma-synthase activity
HVY57_RS10100	COG0586	Pfam SNARE associated Golgi protein
HVY57_RS10105	COG2207	Transcriptional regulator
HVY57_RS10110	COG1979	alcohol dehydrogenase
HVY57_RS10115	COG0656	L-ascorbic acid biosynthetic process
HVY57_RS10120	COG0471	metal ion transport
HVY57_RS10125	COG4238	major outer membrane lipoprotein
HVY57_RS10130	COG1032	radical SAM domain protein
HVY57_RS10135	COG2186	Transcriptional regulator
HVY57_RS10140	COG0246	Mannitol dehydrogenase
HVY57_RS10145	COG1063	alcohol dehydrogenase
HVY57_RS10150	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY57_RS10175	COG0204	Acyl-transferase
HVY57_RS10180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY57_RS10185	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY57_RS10190	COG0745	RESPONSE REGULATOR receiver
HVY57_RS10195	COG0642	Histidine kinase
HVY57_RS10200	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVY57_RS10205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVY57_RS10210	COG0187	DNA topoisomerase II activity
HVY57_RS10215	COG3150	esterase
HVY57_RS10220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVY57_RS10225	COG3151	Protein conserved in bacteria
HVY57_RS10230	COG0494	nUDIX hydrolase
HVY57_RS10235	COG1538	Outer membrane efflux protein
HVY57_RS10245	COG0754	glutathionylspermidine amidase activity
HVY57_RS10255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HVY57_RS10265	COG3384	dioxygenase
HVY57_RS10280	COG3539	Fimbrial protein
HVY57_RS10285	COG3188	usher protein
HVY57_RS10290	COG3121	Chaperone
HVY57_RS10325	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY57_RS10330	COG2268	Band 7 protein
HVY57_RS10365	COG3025	triphosphatase activity
HVY57_RS10370	COG4991	sh3 domain protein
HVY57_RS10385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY57_RS10400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVY57_RS10405	COG0358	DNA primase activity
HVY57_RS10410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY57_RS10470	COG3118	belongs to the thioredoxin family
HVY57_RS10480	COG2375	cellular response to nickel ion
HVY57_RS10485	COG1695	Transcriptional regulator
HVY57_RS10490	COG0840	transmembrane signaling receptor activity
HVY57_RS10500	COG0477	Major facilitator Superfamily
HVY57_RS10505	COG3501	Rhs element vgr protein
HVY57_RS10510	COG2186	Transcriptional regulator
HVY57_RS10515	COG0246	Mannitol dehydrogenase
HVY57_RS10525	COG3065	identical protein binding
HVY57_RS10530	COG2197	response regulator
HVY57_RS10540	COG1285	pathogenesis
HVY57_RS10555	COG3247	response to pH
HVY57_RS10560	COG2771	luxR family
HVY57_RS10565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY57_RS10570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY57_RS10575	COG2207	Transcriptional regulator
HVY57_RS10590	COG1846	Transcriptional regulator
HVY57_RS10615	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS10620	COG4638	Rieske (2fe-2S)
HVY57_RS10625	COG0633	Ferredoxin
HVY57_RS10630	COG2271	Major facilitator Superfamily
HVY57_RS10635	COG3039	Transposase
HVY57_RS10640	COG2271	Major facilitator Superfamily
HVY57_RS10660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY57_RS10665	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVY57_RS10670	COG1924	4 iron, 4 sulfur cluster binding
HVY57_RS10680	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVY57_RS10680	COG1902	pentaerythritol trinitrate reductase activity
HVY57_RS10685	COG0840	transmembrane signaling receptor activity
HVY57_RS10695	COG4145	pantothenate transmembrane transporter activity
HVY57_RS10705	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HVY57_RS10715	COG1846	Transcriptional regulator
HVY57_RS10720	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY57_RS10725	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS10730	COG3384	dioxygenase
HVY57_RS10740	COG3971	2-oxopent-4-enoate hydratase activity
HVY57_RS10760	COG2368	4-hydroxyphenylacetate
HVY57_RS10765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY57_RS10770	COG1966	Carbon starvation protein
HVY57_RS10775	COG2879	small protein
HVY57_RS10780	COG0523	cobalamin synthesis protein
HVY57_RS10790	COG5457	Domain of unknown function (DUF1127)
HVY57_RS10795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY57_RS10805	COG2814	Major facilitator Superfamily
HVY57_RS10810	COG2733	membrane
HVY57_RS10820	COG0582	viral genome integration into host DNA
HVY57_RS10835	COG3039	Transposase
HVY57_RS10870	COG1064	alcohol dehydrogenase
HVY57_RS10875	COG0433	COG0433 Predicted ATPase
HVY57_RS10880	COG0701	Predicted permease
HVY57_RS10900	COG0693	protein deglycase activity
HVY57_RS10915	COG3153	acetyltransferase
HVY57_RS10920	COG3154	lipid carrier protein
HVY57_RS10925	COG0826	peptidase U32
HVY57_RS10930	COG0826	peptidase U32
HVY57_RS10935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY57_RS10940	COG3034	peptidoglycan biosynthetic process
HVY57_RS10985	COG0511	ligase activity, forming carbon-carbon bonds
HVY57_RS11010	COG0814	amino acid
HVY57_RS11015	COG0513	Belongs to the DEAD box helicase family
HVY57_RS11055	COG0195	Participates in both transcription termination and antitermination
HVY57_RS11075	COG2194	sulfuric ester hydrolase activity
HVY57_RS11085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY57_RS11095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVY57_RS11100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVY57_RS11110	COG1534	Rna-binding protein
HVY57_RS11115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY57_RS11120	COG2027	D-alanyl-D-alanine carboxypeptidase
HVY57_RS11130	COG0697	spore germination
HVY57_RS11145	COG0142	geranyltranstransferase activity
HVY57_RS11150	COG3423	Transcriptional regulator
HVY57_RS11160	COG5007	Belongs to the BolA IbaG family
HVY57_RS11165	COG3113	response to antibiotic
HVY57_RS11170	COG2854	intermembrane phospholipid transfer
HVY57_RS11175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY57_RS11180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVY57_RS11185	COG1127	ABC transporter
HVY57_RS11190	COG0530	calcium, potassium:sodium antiporter activity
HVY57_RS11195	COG0517	IMP dehydrogenase activity
HVY57_RS11195	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY57_RS11200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVY57_RS11205	COG3117	lipopolysaccharide transmembrane transporter activity
HVY57_RS11210	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVY57_RS11215	COG1137	ATPase activity
HVY57_RS11220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVY57_RS11225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY57_RS11240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS11245	COG0515	serine threonine protein kinase
HVY57_RS11255	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVY57_RS11260	COG5002	protein histidine kinase activity
HVY57_RS11260	COG2198	Histidine kinase
HVY57_RS11260	COG0784	Response regulator, receiver
HVY57_RS11265	COG1242	4 iron, 4 sulfur cluster binding
HVY57_RS11270	COG0070	glutamate synthase
HVY57_RS11270	COG0069	glutamate synthase activity
HVY57_RS11270	COG0067	glutamate synthase
HVY57_RS11275	COG0493	'glutamate synthase
HVY57_RS11280	COG4804	nuclease activity
HVY57_RS11285	COG2731	YhcH YjgK YiaL family protein
HVY57_RS11315	COG2969	positive regulation of protein catabolic process
HVY57_RS11320	COG0625	glutathione transferase activity
HVY57_RS11335	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVY57_RS11340	COG3105	Protein conserved in bacteria
HVY57_RS11345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY57_RS11350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY57_RS11360	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY57_RS11365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY57_RS11370	COG0471	metal ion transport
HVY57_RS11380	COG1802	Transcriptional regulator
HVY57_RS11400	COG2732	(Barnase) inhibitor
HVY57_RS11420	COG0583	DNA-binding transcription factor activity
HVY57_RS11425	COG0312	modulator of DNA gyrase
HVY57_RS11430	COG3164	Protein of unknown function
HVY57_RS11435	COG1530	ribonuclease E activity
HVY57_RS11445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVY57_RS11450	COG1792	Involved in formation and maintenance of cell shape
HVY57_RS11455	COG1077	Cell shape determining protein MreB Mrl
HVY57_RS11465	COG2200	EAL domain
HVY57_RS11465	COG2199	diguanylate cyclase activity
HVY57_RS11470	COG0604	alcohol dehydrogenase
HVY57_RS11485	COG0511	ligase activity, forming carbon-carbon bonds
HVY57_RS11490	COG0439	Biotin carboxylase
HVY57_RS11495	COG3924	membrane
HVY57_RS11500	COG4145	pantothenate transmembrane transporter activity
HVY57_RS11510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY57_RS11520	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVY57_RS11550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY57_RS11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY57_RS11565	COG4597	amino acid ABC transporter
HVY57_RS11570	COG0765	amino acid transport
HVY57_RS11575	COG1126	abc transporter atp-binding protein
HVY57_RS11615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY57_RS11635	COG0551	DNA topoisomerase type I activity
HVY57_RS11645	COG0758	DNA mediated transformation
HVY57_RS11665	COG0569	domain protein
HVY57_RS11675	COG3036	rescue of stalled ribosome
HVY57_RS11680	COG0789	Transcriptional regulator
HVY57_RS11720	COG0201	protein transport
HVY57_RS11810	COG0089	rRNA binding
HVY57_RS11825	COG0051	transcription antitermination factor activity, RNA binding
HVY57_RS11880	COG2964	Protein conserved in bacteria
HVY57_RS11885	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY57_RS11895	COG1047	Peptidyl-prolyl cis-trans
HVY57_RS11900	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVY57_RS11915	COG0488	(ABC) transporter
HVY57_RS11920	COG0429	hydrolase of the alpha beta-hydrolase fold
HVY57_RS11930	COG3954	Phosphoribulokinase
HVY57_RS11935	COG1765	OsmC-like protein
HVY57_RS11940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY57_RS11945	COG1289	transmembrane transporter activity
HVY57_RS11950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVY57_RS11955	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY57_RS11960	COG2184	nucleotidyltransferase activity
HVY57_RS11975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY57_RS11980	COG2146	nitrite reductase [NAD(P)H] activity
HVY57_RS11985	COG2116	formate transmembrane transporter activity
HVY57_RS12000	COG0626	cystathionine gamma-synthase activity
HVY57_RS12015	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVY57_RS12020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVY57_RS12025	COG3457	Alanine racemase
HVY57_RS12035	COG2188	Transcriptional regulator
HVY57_RS12040	COG0180	Tryptophanyl-tRNA synthetase
HVY57_RS12050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY57_RS12055	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVY57_RS12060	COG3266	domain, Protein
HVY57_RS12075	COG4796	Type ii and iii secretion system protein
HVY57_RS12090	COG3166	PFAM Fimbrial assembly family protein
HVY57_RS12095	COG4972	Pilus assembly protein
HVY57_RS12100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVY57_RS12105	COG0494	nUDIX hydrolase
HVY57_RS12115	COG1011	Hydrolase
HVY57_RS12120	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVY57_RS12130	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY57_RS12155	COG2205	protein histidine kinase activity
HVY57_RS12160	COG0745	RESPONSE REGULATOR receiver
HVY57_RS12165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY57_RS12170	COG2183	response to ionizing radiation
HVY57_RS12175	COG1918	ferrous iron import across plasma membrane
HVY57_RS12180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVY57_RS12190	COG5464	transposase or invertase
HVY57_RS12210	COG2610	gluconate transmembrane transporter activity
HVY57_RS12215	COG1640	4-alpha-glucanotransferase
HVY57_RS12220	COG0058	SHG alpha-glucan phosphorylase activity
HVY57_RS12235	COG1690	Belongs to the RtcB family
HVY57_RS12245	COG1349	DNA-binding transcription factor activity
HVY57_RS12260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY57_RS12285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY57_RS12295	COG3121	Chaperone
HVY57_RS12305	COG3539	Fimbrial protein
HVY57_RS12310	COG3188	usher protein
HVY57_RS12315	COG3121	Chaperone
HVY57_RS12325	COG0058	SHG alpha-glucan phosphorylase activity
HVY57_RS12350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY57_RS12355	COG2095	MarC family integral membrane protein
HVY57_RS12360	COG2610	gluconate transmembrane transporter activity
HVY57_RS12365	COG3265	gluconokinase activity
HVY57_RS12370	COG1609	Transcriptional regulator
HVY57_RS12375	COG1741	Belongs to the pirin family
HVY57_RS12380	COG0673	inositol 2-dehydrogenase activity
HVY57_RS12385	COG1247	-acetyltransferase
HVY57_RS12390	COG0405	Gamma-glutamyltransferase
HVY57_RS12400	COG0584	glycerophosphoryl diester phosphodiesterase
HVY57_RS12415	COG1175	transmembrane transport
HVY57_RS12420	COG1653	transport
HVY57_RS12425	COG0410	ABC transporter
HVY57_RS12430	COG0411	ABC transporter
HVY57_RS12435	COG4177	L-phenylalanine transmembrane transporter activity
HVY57_RS12440	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVY57_RS12445	COG0683	leucine binding
HVY57_RS12450	COG0456	acetyltransferase
HVY57_RS12455	COG0683	leucine binding
HVY57_RS12460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY57_RS12465	COG2177	Part of the ABC transporter FtsEX involved in
HVY57_RS12470	COG2884	Cell division ATP-binding protein ftsE
HVY57_RS12475	COG0552	protein localization to endoplasmic reticulum
HVY57_RS12480	COG0742	ribosomal rna small subunit methyltransferase
HVY57_RS12485	COG3776	membrane
HVY57_RS12495	COG3714	YhhN family
HVY57_RS12510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVY57_RS12525	COG0628	permease
HVY57_RS12555	COG0204	Acyl-transferase
HVY57_RS12565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVY57_RS12585	COG1216	Glycosyl transferase, family 2
HVY57_RS12610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY57_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS12625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY57_RS12630	COG2091	lysine biosynthetic process via aminoadipic acid
HVY57_RS12640	COG0842	Transport permease protein
HVY57_RS12645	COG1129	ABC transporter
HVY57_RS12645	COG0842	Transport permease protein
HVY57_RS12650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY57_RS12675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY57_RS12680	COG2081	HI0933 family
HVY57_RS12685	COG0306	phosphate transporter
HVY57_RS12695	COG0589	response to stress
HVY57_RS12700	COG3104	oligopeptide transport
HVY57_RS12715	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY57_RS12725	COG0584	glycerophosphoryl diester phosphodiesterase
HVY57_RS12730	COG1940	carbohydrate kinase activity
HVY57_RS12740	COG0339	signal peptide processing
HVY57_RS12745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVY57_RS12750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY57_RS12760	COG0640	Transcriptional regulator
HVY57_RS12765	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY57_RS12770	COG1393	Belongs to the ArsC family
HVY57_RS12790	COG2197	response regulator
HVY57_RS12800	COG1295	ribonuclease BN
HVY57_RS12805	COG0477	Major facilitator Superfamily
HVY57_RS12810	COG2982	Protein involved in outer membrane biogenesis
HVY57_RS12815	COG2200	EAL domain
HVY57_RS12820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY57_RS12870	COG0612	Peptidase, M16
HVY57_RS12880	COG2200	EAL domain
HVY57_RS12880	COG2199	diguanylate cyclase activity
HVY57_RS12885	COG0457	Tetratricopeptide repeat
HVY57_RS12885	COG3118	belongs to the thioredoxin family
HVY57_RS12890	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVY57_RS12895	COG1215	transferase activity, transferring glycosyl groups
HVY57_RS12900	COG1215	transferase activity, transferring glycosyl groups
HVY57_RS12925	COG2194	sulfuric ester hydrolase activity
HVY57_RS12955	COG0814	amino acid
HVY57_RS12965	COG4608	Belongs to the ABC transporter superfamily
HVY57_RS12970	COG0444	Belongs to the ABC transporter superfamily
HVY57_RS12975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY57_RS12980	COG0601	transmembrane transport
HVY57_RS12985	COG0747	negative chemotaxis
HVY57_RS13000	COG2194	sulfuric ester hydrolase activity
HVY57_RS13005	COG2223	nitrite transmembrane transporter activity
HVY57_RS13010	COG5571	outer membrane autotransporter
HVY57_RS13015	COG2818	Glycosylase
HVY57_RS13020	COG0456	acetyltransferase
HVY57_RS13025	COG0243	molybdopterin cofactor binding
HVY57_RS13030	COG2885	chlorophyll binding
HVY57_RS13035	COG1609	Transcriptional regulator
HVY57_RS13045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY57_RS13065	COG2814	Major facilitator Superfamily
HVY57_RS13070	COG2944	sequence-specific DNA binding
HVY57_RS13075	COG1278	Cold shock
HVY57_RS13100	COG3274	enterobacterial common antigen metabolic process
HVY57_RS13105	COG4682	membrane
HVY57_RS13110	COG1070	Carbohydrate kinase
HVY57_RS13120	COG1609	Transcriptional regulator
HVY57_RS13120	COG2207	Transcriptional regulator
HVY57_RS13125	COG2992	FlgJ-related protein
HVY57_RS13130	COG0366	Alpha amylase catalytic
HVY57_RS13135	COG3977	Valine--pyruvate aminotransferase
HVY57_RS13140	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY57_RS13145	COG1414	Transcriptional regulator
HVY57_RS13155	COG2731	YhcH YjgK YiaL family protein
HVY57_RS13160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY57_RS13165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY57_RS13170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY57_RS13175	COG1070	Carbohydrate kinase
HVY57_RS13180	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HVY57_RS13185	COG3623	hexulose-6-phosphate isomerase
HVY57_RS13190	COG0235	Class ii aldolase
HVY57_RS13195	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS13200	COG1454	alcohol dehydrogenase
HVY57_RS13205	COG3276	selenocysteine insertion sequence binding
HVY57_RS13215	COG0625	glutathione transferase activity
HVY57_RS13220	COG1566	PFAM secretion protein HlyD family protein
HVY57_RS13230	COG2213	PTS system mannitol-specific
HVY57_RS13230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS13240	COG3722	fumarate hydratase activity
HVY57_RS13260	COG5295	Hep Hag repeat protein
HVY57_RS13270	COG2186	Transcriptional regulator
HVY57_RS13280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVY57_RS13285	COG1045	serine acetyltransferase
HVY57_RS13300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY57_RS13305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY57_RS13315	COG4942	peptidase
HVY57_RS13320	COG2861	carbohydrate metabolic process
HVY57_RS13325	COG1216	Glycosyl transferase, family 2
HVY57_RS13330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY57_RS13335	COG3078	GTPase activator activity
HVY57_RS13350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVY57_RS13350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVY57_RS13355	COG0204	Acyl-transferase
HVY57_RS13360	COG5339	Protein conserved in bacteria
HVY57_RS13365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY57_RS13370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVY57_RS13375	COG3084	Protein conserved in bacteria
HVY57_RS13380	COG0746	molybdenum cofactor guanylyltransferase activity
HVY57_RS13385	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVY57_RS13415	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVY57_RS13420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY57_RS13425	COG1739	Uncharacterized protein family UPF0029
HVY57_RS13450	COG0543	2 iron, 2 sulfur cluster binding
HVY57_RS13455	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY57_RS13460	COG0250	Participates in transcription elongation, termination and antitermination
HVY57_RS13470	COG0805	protein transport
HVY57_RS13475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY57_RS13480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY57_RS13490	COG3165	ubiquinone biosynthetic process from chorismate
HVY57_RS13500	COG1322	Protein conserved in bacteria
HVY57_RS13505	COG1414	Transcriptional regulator
HVY57_RS13510	COG3734	2-keto-3-deoxy-galactonokinase
HVY57_RS13515	COG0800	Aldolase
HVY57_RS13535	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVY57_RS13540	COG0412	Dienelactone hydrolase
HVY57_RS13545	COG2188	Transcriptional regulator
HVY57_RS13565	COG0583	DNA-binding transcription factor activity
HVY57_RS13580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HVY57_RS13585	COG2828	Protein conserved in bacteria
HVY57_RS13590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY57_RS13595	COG0473	3-isopropylmalate dehydrogenase activity
HVY57_RS13600	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVY57_RS13615	COG0583	DNA-binding transcription factor activity
HVY57_RS13620	COG0697	spore germination
HVY57_RS13625	COG0561	phosphatase activity
HVY57_RS13630	COG2267	carboxylic ester hydrolase activity
HVY57_RS13635	COG1280	lysine exporter protein (LysE YggA)
HVY57_RS13645	COG1280	lysine exporter protein (LysE YggA)
HVY57_RS13650	COG0514	ATP-dependent DNA helicase (RecQ)
HVY57_RS13655	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVY57_RS13660	COG2050	protein possibly involved in aromatic compounds catabolism
HVY57_RS13665	COG2962	Rard protein
HVY57_RS13675	COG0598	Magnesium transport protein CorA
HVY57_RS13680	COG3698	Phosphodiester glycosidase
HVY57_RS13685	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HVY57_RS13690	COG0210	DNA helicase
HVY57_RS13695	COG1011	Hydrolase
HVY57_RS13705	COG3159	Protein conserved in bacteria
HVY57_RS13715	COG5567	small periplasmic lipoprotein
HVY57_RS13735	COG3072	Adenylate cyclase
HVY57_RS13750	COG2959	enzyme of heme biosynthesis
HVY57_RS13755	COG3071	HemY protein
HVY57_RS13780	COG0641	radical SAM
HVY57_RS13805	COG1113	amino acid transport
HVY57_RS13825	COG2244	polysaccharide biosynthetic process
HVY57_RS13830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVY57_RS13835	COG0456	acetyltransferase
HVY57_RS13840	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY57_RS13845	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY57_RS13850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVY57_RS13855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVY57_RS13860	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY57_RS13865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVY57_RS13870	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVY57_RS13880	COG3118	belongs to the thioredoxin family
HVY57_RS13895	COG0210	DNA helicase
HVY57_RS13900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY57_RS13910	COG0583	DNA-binding transcription factor activity
HVY57_RS13915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY57_RS13925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY57_RS13930	COG3978	acetolactate synthase activity
HVY57_RS13950	COG0606	chelatase, subunit chli
HVY57_RS13955	COG3085	chromosome segregation
HVY57_RS13995	COG2186	Transcriptional regulator
HVY57_RS14000	COG1609	Transcriptional regulator
HVY57_RS14005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY57_RS14010	COG1879	ABC-type sugar transport system periplasmic component
HVY57_RS14015	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY57_RS14020	COG1129	ABC transporter
HVY57_RS14050	COG1522	sequence-specific DNA binding
HVY57_RS14055	COG0716	FMN binding
HVY57_RS14070	COG3312	ion transport
HVY57_RS14130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY57_RS14135	COG0573	inorganic phosphate transmembrane transporter activity
HVY57_RS14140	COG0581	inorganic phosphate transmembrane transporter activity
HVY57_RS14145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVY57_RS14150	COG0704	Plays a role in the regulation of phosphate uptake
HVY57_RS14155	COG3711	transcriptional antiterminator
HVY57_RS14160	COG2190	(PTS) system
HVY57_RS14160	COG1263	PTS System
HVY57_RS14160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY57_RS14165	COG2723	6-phospho-beta-galactosidase activity
HVY57_RS14175	COG2382	esterase
HVY57_RS14180	COG0363	glucosamine-6-phosphate deaminase activity
HVY57_RS14185	COG3196	Protein conserved in bacteria
HVY57_RS14195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY57_RS14200	COG2252	PERMEase
HVY57_RS14210	COG0431	NADPH-dependent FMN reductase
HVY57_RS14215	COG2091	lysine biosynthetic process via aminoadipic acid
HVY57_RS14230	COG0814	amino acid
HVY57_RS14280	COG0592	DNA-directed DNA polymerase activity
HVY57_RS14290	COG0187	DNA topoisomerase II activity
HVY57_RS14295	COG3753	Protein conserved in bacteria
HVY57_RS14300	COG0561	phosphatase activity
HVY57_RS14310	COG2186	Transcriptional regulator
HVY57_RS14315	COG3734	2-keto-3-deoxy-galactonokinase
HVY57_RS14320	COG0800	Aldolase
HVY57_RS14330	COG2271	Major facilitator Superfamily
HVY57_RS14340	COG0823	Involved in the tonB-independent uptake of proteins
HVY57_RS14345	COG5645	(Lipo)protein
HVY57_RS14365	COG2188	Transcriptional regulator
HVY57_RS14380	COG2207	Transcriptional regulator
HVY57_RS14385	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY57_RS14390	COG3119	arylsulfatase activity
HVY57_RS14400	COG2149	membrane
HVY57_RS14410	COG0641	radical SAM
HVY57_RS14415	COG2814	Major facilitator Superfamily
HVY57_RS14430	COG0028	Belongs to the TPP enzyme family
HVY57_RS14435	COG0440	acetolactate synthase activity
HVY57_RS14440	COG2197	response regulator
HVY57_RS14445	COG3851	Histidine kinase
HVY57_RS14450	COG2271	Major facilitator Superfamily
HVY57_RS14455	COG2271	Major facilitator Superfamily
HVY57_RS14475	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY57_RS14480	COG2723	6-phospho-beta-galactosidase activity
HVY57_RS14485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY57_RS14495	COG1609	Transcriptional regulator
HVY57_RS14505	COG0697	spore germination
HVY57_RS14565	COG1196	nuclear chromosome segregation
HVY57_RS14570	COG0582	viral genome integration into host DNA
HVY57_RS14580	COG2211	Major facilitator Superfamily
HVY57_RS14585	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY57_RS14590	COG2982	Protein involved in outer membrane biogenesis
HVY57_RS14595	COG2233	PERMEase
HVY57_RS14600	COG0786	glutamate:sodium symporter activity
HVY57_RS14610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVY57_RS14615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY57_RS14620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY57_RS14630	COG0194	GDP metabolic process
HVY57_RS14640	COG2860	membrane
HVY57_RS14645	COG1561	YicC-like family, N-terminal region
HVY57_RS14675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVY57_RS14705	COG1519	Transferase
HVY57_RS14710	COG0859	PFAM glycosyl transferase family 9
HVY57_RS14715	COG0438	transferase activity, transferring glycosyl groups
HVY57_RS14720	COG0515	serine threonine protein kinase
HVY57_RS14725	COG4641	Protein conserved in bacteria
HVY57_RS14725	COG0438	transferase activity, transferring glycosyl groups
HVY57_RS14730	COG0438	transferase activity, transferring glycosyl groups
HVY57_RS14735	COG1442	glycosyl transferase family 8
HVY57_RS14740	COG1442	glycosyl transferase family 8
HVY57_RS14745	COG3642	lipopolysaccharide core region biosynthetic process
HVY57_RS14765	COG0859	PFAM glycosyl transferase family 9
HVY57_RS14770	COG0859	PFAM glycosyl transferase family 9
HVY57_RS14780	COG0156	8-amino-7-oxononanoate synthase activity
HVY57_RS14795	COG2204	response regulator
HVY57_RS14800	COG3852	Histidine kinase
HVY57_RS14805	COG0174	glutamine synthetase
HVY57_RS14815	COG0561	phosphatase activity
HVY57_RS14825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY57_RS14845	COG1011	Hydrolase
HVY57_RS14860	COG0456	acetyltransferase
HVY57_RS14880	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY57_RS14890	COG2864	formate dehydrogenase
HVY57_RS14895	COG0437	4 iron, 4 sulfur cluster binding
HVY57_RS14910	COG0326	Molecular chaperone. Has ATPase activity
HVY57_RS14920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS14920	COG3711	transcriptional antiterminator
HVY57_RS14925	COG1363	Peptidase, m42
HVY57_RS14930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS14930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS14935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS14945	COG1454	alcohol dehydrogenase
HVY57_RS14980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY57_RS14985	COG2258	MOSC domain
HVY57_RS14990	COG2205	protein histidine kinase activity
HVY57_RS14995	COG0745	RESPONSE REGULATOR receiver
HVY57_RS15000	COG3678	ATP-independent chaperone mediated protein folding
HVY57_RS15015	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVY57_RS15035	COG3152	Membrane
HVY57_RS15040	COG3691	Protein conserved in bacteria
HVY57_RS15045	COG0589	response to stress
HVY57_RS15055	COG1494	fructose-1,6-bisphosphatase
HVY57_RS15065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVY57_RS15080	COG1575	Belongs to the MenA family. Type 1 subfamily
HVY57_RS15095	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY57_RS15100	COG1609	Transcriptional regulator
HVY57_RS15105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVY57_RS15120	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVY57_RS15130	COG0626	cystathionine gamma-synthase activity
HVY57_RS15135	COG0460	homoserine dehydrogenase
HVY57_RS15135	COG0527	aspartate kinase activity
HVY57_RS15145	COG0737	Belongs to the 5'-nucleotidase family
HVY57_RS15150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVY57_RS15160	COG0697	spore germination
HVY57_RS15165	COG3738	Protein conserved in bacteria
HVY57_RS15170	COG0371	Dehydrogenase
HVY57_RS15175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY57_RS15180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS15180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS15180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY57_RS15185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS15190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS15195	COG1882	Formate acetyltransferase
HVY57_RS15200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY57_RS15205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS15210	COG2207	Transcriptional regulator
HVY57_RS15215	COG2194	sulfuric ester hydrolase activity
HVY57_RS15230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVY57_RS15245	COG0583	DNA-binding transcription factor activity
HVY57_RS15255	COG1473	amidohydrolase
HVY57_RS15260	COG0477	Major facilitator Superfamily
HVY57_RS15265	COG1309	transcriptional regulator
HVY57_RS15310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVY57_RS15315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVY57_RS15315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVY57_RS15350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY57_RS15355	COG0250	Participates in transcription elongation, termination and antitermination
HVY57_RS15390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVY57_RS15400	COG2104	thiamine diphosphate biosynthetic process
HVY57_RS15405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY57_RS15440	COG3068	Protein conserved in bacteria
HVY57_RS15455	COG3678	ATP-independent chaperone mediated protein folding
HVY57_RS15460	COG4191	Histidine kinase
HVY57_RS15465	COG2204	response regulator
HVY57_RS15470	COG0151	Belongs to the GarS family
HVY57_RS15500	COG0456	acetyltransferase
HVY57_RS15510	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY57_RS15515	COG2224	Isocitrate lyase
HVY57_RS15530	COG1414	Transcriptional regulator
HVY57_RS15535	COG0646	methionine synthase
HVY57_RS15535	COG1410	methionine synthase
HVY57_RS15550	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVY57_RS15555	COG3122	Protein conserved in bacteria
HVY57_RS15595	COG1187	pseudouridine synthase activity
HVY57_RS15610	COG3541	Predicted nucleotidyltransferase
HVY57_RS15615	COG0542	response to heat
HVY57_RS15620	COG0527	aspartate kinase activity
HVY57_RS15645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY57_RS15660	COG2814	Major facilitator Superfamily
HVY57_RS15660	COG0477	Major facilitator Superfamily
HVY57_RS15665	COG3833	ABC-type maltose transport systems, permease component
HVY57_RS15670	COG1175	transmembrane transport
HVY57_RS15675	COG2182	Extracellular solute-binding protein
HVY57_RS15680	COG3842	ATPase activity
HVY57_RS15710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVY57_RS15720	COG0534	Mate efflux family protein
HVY57_RS15725	COG3237	CsbD-like
HVY57_RS15730	COG0735	belongs to the Fur family
HVY57_RS15735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY57_RS15745	COG0604	alcohol dehydrogenase
HVY57_RS15750	COG0305	Participates in initiation and elongation during chromosome replication
HVY57_RS15760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY57_RS15780	COG1448	Aminotransferase
HVY57_RS15790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY57_RS15795	COG0471	metal ion transport
HVY57_RS15800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY57_RS15805	COG2204	response regulator
HVY57_RS15815	COG3700	Belongs to the class B bacterial acid phosphatase family
HVY57_RS15820	COG0432	Pfam Uncharacterised protein family UPF0047
HVY57_RS15825	COG2315	Protein conserved in bacteria
HVY57_RS15830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVY57_RS15835	COG0629	single-stranded DNA binding
HVY57_RS15850	COG0789	Transcriptional regulator
HVY57_RS15855	COG2252	PERMEase
HVY57_RS15860	COG0025	NhaP-type Na H and K H
HVY57_RS15865	COG2824	Alkylphosphonate utilization operon protein PhnA
HVY57_RS15870	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVY57_RS15885	COG0642	Histidine kinase
HVY57_RS15890	COG0745	RESPONSE REGULATOR receiver
HVY57_RS15895	COG2194	sulfuric ester hydrolase activity
HVY57_RS15900	COG2207	Transcriptional regulator
HVY57_RS15905	COG3647	Membrane
HVY57_RS15910	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY57_RS15910	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY57_RS15915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY57_RS15920	COG4565	transcriptional regulatory protein
HVY57_RS15925	COG3290	protein histidine kinase activity
HVY57_RS15930	COG0243	molybdopterin cofactor binding
HVY57_RS15935	COG0437	4 iron, 4 sulfur cluster binding
HVY57_RS15940	COG3302	dmso reductase anchor subunit
HVY57_RS15945	COG3381	protein complex oligomerization
HVY57_RS15960	COG1309	transcriptional regulator
HVY57_RS15965	COG4232	protein-disulfide reductase activity
HVY57_RS15975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY57_RS15980	COG1027	Aspartate ammonia-lyase
HVY57_RS15985	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVY57_RS15990	COG0531	amino acid
HVY57_RS16015	COG1509	lysine 2,3-aminomutase activity
HVY57_RS16025	COG5510	response to toxic substance
HVY57_RS16030	COG5510	response to toxic substance
HVY57_RS16035	COG2076	Multidrug Resistance protein
HVY57_RS16040	COG3040	lipid binding
HVY57_RS16045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY57_RS16060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY57_RS16065	COG1053	succinate dehydrogenase
HVY57_RS16075	COG0531	amino acid
HVY57_RS16085	COG3264	Mechanosensitive ion channel
HVY57_RS16085	COG1511	domain protein
HVY57_RS16105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY57_RS16130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVY57_RS16135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVY57_RS16135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVY57_RS16140	COG0802	atpase or kinase
HVY57_RS16145	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY57_RS16165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVY57_RS16170	COG0330	HflC and HflK could
HVY57_RS16175	COG0330	HflC and HflK could
HVY57_RS16180	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVY57_RS16195	COG0557	exoribonuclease II activity
HVY57_RS16200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY57_RS16205	COG3789	protein conserved in bacteria
HVY57_RS16210	COG1842	Phage shock protein A
HVY57_RS16220	COG3766	membrane
HVY57_RS16225	COG5463	Belongs to the UPF0441 family
HVY57_RS16230	COG0754	glutathionylspermidine amidase activity
HVY57_RS16235	COG1960	acyl-CoA dehydrogenase activity
HVY57_RS16245	COG3650	response to hydrogen peroxide
HVY57_RS16250	COG1073	alpha beta
HVY57_RS16265	COG3037	sugar-specific permease SgaT UlaA
HVY57_RS16270	COG3414	Phosphotransferase system galactitol-specific IIB component
HVY57_RS16310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVY57_RS16320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY57_RS16330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY57_RS16335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY57_RS16340	COG4670	ketone body catabolic process
HVY57_RS16370	COG1309	transcriptional regulator
HVY57_RS16375	COG3061	Opacity-associated protein A
HVY57_RS16380	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY57_RS16385	COG1113	amino acid transport
HVY57_RS16395	COG0697	spore germination
HVY57_RS16400	COG0702	epimerase
HVY57_RS16405	COG1733	regulation of RNA biosynthetic process
HVY57_RS16410	COG0737	Belongs to the 5'-nucleotidase family
HVY57_RS16415	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVY57_RS16420	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY57_RS16430	COG1253	flavin adenine dinucleotide binding
HVY57_RS16435	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVY57_RS16445	COG0698	ribose 5-phosphate isomerase
HVY57_RS16450	COG1737	Transcriptional regulator
HVY57_RS16455	COG1879	ABC-type sugar transport system periplasmic component
HVY57_RS16460	COG1129	ABC transporter
HVY57_RS16465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY57_RS16470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY57_RS16475	COG1940	carbohydrate kinase activity
HVY57_RS16490	COG1289	transmembrane transporter activity
HVY57_RS16505	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY57_RS16510	COG1301	dicarboxylic acid transport
HVY57_RS16515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY57_RS16520	COG3162	membrane
HVY57_RS16535	COG0729	surface antigen
HVY57_RS16540	COG2911	Protein conserved in bacteria
HVY57_RS16545	COG2105	PFAM AIG2 family protein
HVY57_RS16550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVY57_RS16555	COG1879	ABC-type sugar transport system periplasmic component
HVY57_RS16560	COG1129	ABC transporter
HVY57_RS16565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY57_RS16570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY57_RS16580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVY57_RS16590	COG0312	modulator of DNA gyrase
HVY57_RS16595	COG3783	Cytochrome b(562)
HVY57_RS16600	COG3077	Addiction module antitoxin, RelB DinJ family
HVY57_RS16605	COG2026	Addiction module toxin, RelE StbE family
HVY57_RS16610	COG0602	queuosine metabolic process
HVY57_RS16615	COG1328	CTP reductase activity
HVY57_RS16620	COG0366	Alpha amylase catalytic
HVY57_RS16625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY57_RS16625	COG1263	PTS System
HVY57_RS16630	COG1609	Transcriptional regulator
HVY57_RS16640	COG0251	oxidation-reduction process
HVY57_RS16660	COG1438	arginine binding
HVY57_RS16665	COG1288	antiporter activity
HVY57_RS16670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVY57_RS16675	COG0549	Belongs to the carbamate kinase family
HVY57_RS16685	COG2731	YhcH YjgK YiaL family protein
HVY57_RS16690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVY57_RS16695	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVY57_RS16700	COG0456	acetyltransferase
HVY57_RS16730	COG0525	valine-tRNA ligase activity
HVY57_RS16735	COG2927	DNA polymerase III (CHI subunit)
HVY57_RS16745	COG0795	lipopolysaccharide-transporting ATPase activity
HVY57_RS16750	COG0795	lipopolysaccharide-transporting ATPase activity
HVY57_RS16755	COG2823	Periplasmic or secreted lipoprotein
HVY57_RS16775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVY57_RS16780	COG0363	glucosamine-6-phosphate deaminase activity
HVY57_RS16785	COG3716	PTS system mannose fructose sorbose family IID component
HVY57_RS16790	COG3715	PTS system
HVY57_RS16795	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY57_RS16805	COG2222	sugar isomerase
HVY57_RS16810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY57_RS16815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS16820	COG3716	PTS system mannose fructose sorbose family IID component
HVY57_RS16830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY57_RS16840	COG1349	DNA-binding transcription factor activity
HVY57_RS16850	COG2002	toxin-antitoxin pair type II binding
HVY57_RS16855	COG2721	sulfolactate sulfo-lyase activity
HVY57_RS16865	COG2084	Dehydrogenase
HVY57_RS16875	COG1741	Belongs to the pirin family
HVY57_RS16880	COG0583	DNA-binding transcription factor activity
HVY57_RS16900	COG0435	Glutathione S-transferase
HVY57_RS16905	COG2259	Doxx family
HVY57_RS16915	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVY57_RS16920	COG4575	ribosome binding
HVY57_RS16925	COG1422	Protein of unknown function (DUF1090)
HVY57_RS16935	COG0586	Pfam SNARE associated Golgi protein
HVY57_RS16940	COG2186	Transcriptional regulator
HVY57_RS16945	COG2271	Major facilitator Superfamily
HVY57_RS16955	COG2721	sulfolactate sulfo-lyase activity
HVY57_RS16965	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVY57_RS16970	COG0861	Integral membrane protein TerC family
HVY57_RS16975	COG0673	inositol 2-dehydrogenase activity
HVY57_RS16980	COG2949	membrane
HVY57_RS16985	COG1451	nucleotide metabolic process
HVY57_RS17010	COG1484	DNA-dependent DNA replication
HVY57_RS17025	COG2966	Psort location CytoplasmicMembrane, score
HVY57_RS17035	COG2169	Transcriptional regulator
HVY57_RS17035	COG1917	Cupin 2, conserved barrel domain protein
HVY57_RS17040	COG2197	response regulator
HVY57_RS17045	COG2197	response regulator
HVY57_RS17050	COG4114	ferric iron reductase
HVY57_RS17080	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVY57_RS17085	COG0456	acetyltransferase
HVY57_RS17090	COG1011	Hydrolase
HVY57_RS17110	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HVY57_RS17115	COG5532	Uncharacterized conserved protein (DUF2303)
HVY57_RS17140	COG0484	heat shock protein binding
HVY57_RS17150	COG1278	Cold shock
HVY57_RS17155	COG1278	Cold shock
HVY57_RS17175	COG3772	lysozyme
HVY57_RS17185	COG1278	Cold shock
HVY57_RS17225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY57_RS17230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY57_RS17255	COG2823	Periplasmic or secreted lipoprotein
HVY57_RS17265	COG4667	esterase of the alpha-beta hydrolase superfamily
HVY57_RS17270	COG0084	hydrolase, TatD family'
HVY57_RS17275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY57_RS17280	COG1328	CTP reductase activity
HVY57_RS17315	COG3726	membrane protein affecting hemolysin expression
HVY57_RS17320	COG0560	Phosphoserine phosphatase
HVY57_RS17325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVY57_RS17330	COG1056	cytidyltransferase-related domain
HVY57_RS17330	COG3172	ATPase kinase involved in NAD metabolism
HVY57_RS17335	COG0488	(ABC) transporter
HVY57_RS17340	COG0741	lytic transglycosylase activity
HVY57_RS17360	COG2207	Transcriptional regulator
HVY57_RS17360	COG3708	Transcriptional regulator
HVY57_RS17365	COG3045	CreA protein
HVY57_RS17370	COG0745	RESPONSE REGULATOR receiver
HVY57_RS17375	COG2205	protein histidine kinase activity
HVY57_RS17380	COG4452	Inner membrane protein CreD
HVY57_RS17385	COG0745	RESPONSE REGULATOR receiver
HVY57_RS17395	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVY57_RS17405	COG0460	homoserine dehydrogenase
HVY57_RS17405	COG0527	aspartate kinase activity
HVY57_RS17415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVY57_RS17430	COG1115	amino acid carrier protein
HVY57_RS17440	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY57_RS17445	COG1584	GPR1 FUN34 yaaH family protein
HVY57_RS17470	COG0583	DNA-binding transcription factor activity
HVY57_RS17485	COG0196	riboflavin kinase activity
HVY57_RS17500	COG1047	Peptidyl-prolyl cis-trans
HVY57_RS17540	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HVY57_RS17545	COG5016	pyruvate
HVY57_RS17545	COG0511	ligase activity, forming carbon-carbon bonds
HVY57_RS17600	COG0505	Belongs to the CarA family
HVY57_RS17605	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVY57_RS17655	COG0644	oxidoreductase
HVY57_RS17660	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY57_RS17665	COG2271	Major facilitator Superfamily
HVY57_RS17680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVY57_RS17715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY57_RS17725	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVY57_RS17730	COG0564	pseudouridine synthase activity
HVY57_RS17740	COG0417	DNA replication proofreading
HVY57_RS17745	COG0235	Class ii aldolase
HVY57_RS17780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY57_RS17790	COG3181	Tripartite tricarboxylate transporter family receptor
HVY57_RS17805	COG0586	Pfam SNARE associated Golgi protein
HVY57_RS17815	COG1178	ABC-type Fe3 transport system permease component
HVY57_RS17820	COG4143	(ABC) transporter
HVY57_RS17835	COG2814	Major facilitator Superfamily
HVY57_RS17840	COG2271	Major facilitator Superfamily
HVY57_RS17845	COG0583	DNA-binding transcription factor activity
HVY57_RS17855	COG0738	Major facilitator superfamily
HVY57_RS17900	COG0028	Belongs to the TPP enzyme family
HVY57_RS17905	COG0440	acetolactate synthase activity
HVY57_RS17915	COG1609	Transcriptional regulator
HVY57_RS17930	COG3116	cell division
HVY57_RS17935	COG0768	penicillin binding
HVY57_RS17940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY57_RS17945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVY57_RS17960	COG0772	Belongs to the SEDS family
HVY57_RS17975	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY57_RS17980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVY57_RS17985	COG0849	cell division
HVY57_RS17990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVY57_RS18010	COG0494	nUDIX hydrolase
HVY57_RS18025	COG0237	dephospho-CoA kinase activity
HVY57_RS18035	COG1459	type II secretion system
HVY57_RS18040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY57_RS18045	COG4969	Belongs to the N-Me-Phe pilin family
HVY57_RS18050	COG0157	Belongs to the NadC ModD family
HVY57_RS18055	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY57_RS18060	COG3725	Membrane protein required for beta-lactamase induction
HVY57_RS18065	COG1113	amino acid transport
HVY57_RS18070	COG2186	Transcriptional regulator
HVY57_RS18075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVY57_RS18080	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY57_RS18085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY57_RS18090	COG3064	Membrane
HVY57_RS18095	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVY57_RS18120	COG2132	Multicopper oxidase
HVY57_RS18125	COG4993	Dehydrogenase
HVY57_RS18130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVY57_RS18135	COG0288	reversible hydration of carbon dioxide
HVY57_RS18140	COG1131	(ABC) transporter
HVY57_RS18145	COG0842	Transport permease protein
HVY57_RS18150	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS18155	COG0726	polysaccharide deacetylase
HVY57_RS18165	COG5464	transposase or invertase
HVY57_RS18190	COG3539	Fimbrial protein
HVY57_RS18195	COG3539	Fimbrial protein
HVY57_RS18200	COG3188	usher protein
HVY57_RS18205	COG3121	Chaperone
HVY57_RS18215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVY57_RS18220	COG0617	tRNA 3'-terminal CCA addition
HVY57_RS18230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY57_RS18240	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVY57_RS18245	COG1643	Atp-dependent helicase
HVY57_RS18250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVY57_RS18255	COG4774	siderophore transport
HVY57_RS18260	COG1120	ATPase activity
HVY57_RS18265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY57_RS18270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY57_RS18295	COG2860	membrane
HVY57_RS18300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY57_RS18315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY57_RS18320	COG3835	regulator
HVY57_RS18330	COG1408	metallophosphoesterase
HVY57_RS18345	COG0024	Methionine aminopeptidase
HVY57_RS18370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVY57_RS18375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVY57_RS18380	COG0575	Belongs to the CDS family
HVY57_RS18385	COG0750	zinc metalloprotease
HVY57_RS18395	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVY57_RS18400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVY57_RS18425	COG0587	DNA-directed DNA polymerase activity
HVY57_RS18440	COG0346	lactoylglutathione lyase activity
HVY57_RS18445	COG0037	tRNA processing
HVY57_RS18450	COG4568	rho-dependent transcription termination
HVY57_RS18460	COG4681	YaeQ
HVY57_RS18465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY57_RS18470	COG3015	lipoprotein NlpE involved in copper resistance
HVY57_RS18475	COG0791	NLP P60 protein
HVY57_RS18485	COG1720	tRNA m6t6A37 methyltransferase activity
HVY57_RS18495	COG1464	Belongs to the NlpA lipoprotein family
HVY57_RS18500	COG2011	ABC-type metal ion transport system permease component
HVY57_RS18510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY57_RS18545	COG0582	viral genome integration into host DNA
HVY57_RS18550	COG3423	Transcriptional regulator
HVY57_RS18570	COG3328	transposase activity
HVY57_RS18635	COG0656	L-ascorbic acid biosynthetic process
HVY57_RS18640	COG0583	DNA-binding transcription factor activity
HVY57_RS18650	COG2226	methyltransferase
HVY57_RS18655	COG0741	lytic transglycosylase activity
HVY57_RS18655	COG1388	LysM domain
HVY57_RS18665	COG2226	methyltransferase
HVY57_RS18675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY57_RS18685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY57_RS18695	COG1960	acyl-CoA dehydrogenase activity
HVY57_RS18705	COG0121	glutamine amidotransferase
HVY57_RS18710	COG3034	peptidoglycan biosynthetic process
HVY57_RS18715	COG0791	NLP P60 protein
HVY57_RS18725	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY57_RS18745	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVY57_RS18750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVY57_RS18755	COG2166	iron-sulfur cluster assembly
HVY57_RS18760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVY57_RS18770	COG0583	DNA-binding transcription factor activity
HVY57_RS18775	COG2363	Small membrane protein
HVY57_RS18790	COG1760	l-serine dehydratase
HVY57_RS18795	COG0814	amino acid
HVY57_RS18800	COG1611	Belongs to the LOG family
HVY57_RS18815	COG3098	single-species biofilm formation
HVY57_RS18820	COG0564	pseudouridine synthase activity
HVY57_RS18825	COG0716	FMN binding
HVY57_RS18855	COG4948	Mandelate Racemase Muconate Lactonizing
HVY57_RS18860	COG4948	Mandelate Racemase Muconate Lactonizing
HVY57_RS18865	COG1929	Belongs to the glycerate kinase type-1 family
HVY57_RS18870	COG2205	protein histidine kinase activity
HVY57_RS18870	COG4999	Histidine kinase
HVY57_RS18870	COG3850	Histidine kinase
HVY57_RS18870	COG3437	response regulator, receiver
HVY57_RS18875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVY57_RS18880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY57_RS18885	COG3956	TIGRFAM MazG family protein
HVY57_RS18900	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY57_RS18910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY57_RS18920	COG0602	queuosine metabolic process
HVY57_RS18930	COG0720	synthase
HVY57_RS18965	COG1857	crispr-associated protein
HVY57_RS18980	COG1518	maintenance of DNA repeat elements
HVY57_RS18985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY57_RS18990	COG2234	aminopeptidase activity
HVY57_RS19045	COG4942	peptidase
HVY57_RS19045	COG1388	LysM domain
HVY57_RS19050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY57_RS19070	COG0163	prenyltransferase activity
HVY57_RS19075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY57_RS19085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY57_RS19120	COG1129	ABC transporter
HVY57_RS19125	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY57_RS19145	COG1349	DNA-binding transcription factor activity
HVY57_RS19160	COG3604	Transcriptional regulator
HVY57_RS19165	COG0309	Hydrogenase expression formation protein (HypE)
HVY57_RS19170	COG0409	Hydrogenase expression formation protein
HVY57_RS19175	COG0298	carbon dioxide binding
HVY57_RS19180	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVY57_RS19185	COG0375	protein maturation
HVY57_RS19195	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY57_RS19200	COG0651	ATP synthesis coupled electron transport
HVY57_RS19205	COG0650	Formate hydrogenlyase subunit 4
HVY57_RS19210	COG3261	NADH dehydrogenase
HVY57_RS19210	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY57_RS19215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY57_RS19220	COG3260	NADH ubiquinone oxidoreductase 20
HVY57_RS19230	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY57_RS19235	COG2723	6-phospho-beta-galactosidase activity
HVY57_RS19240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY57_RS19240	COG1263	PTS System
HVY57_RS19245	COG1609	Transcriptional regulator
HVY57_RS19250	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY57_RS19255	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVY57_RS19275	COG0517	IMP dehydrogenase activity
HVY57_RS19275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY57_RS19285	COG2951	lytic endotransglycosylase activity
HVY57_RS19295	COG1546	Belongs to the CinA family
HVY57_RS19315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVY57_RS19345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY57_RS19350	COG1238	metal cluster binding
HVY57_RS19365	COG2814	Major facilitator Superfamily
HVY57_RS19370	COG1566	PFAM secretion protein HlyD family protein
HVY57_RS19375	COG1846	Transcriptional regulator
HVY57_RS19385	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY57_RS19390	COG2814	Major facilitator Superfamily
HVY57_RS19395	COG2113	Glycine betaine
HVY57_RS19400	COG4176	ABC-type proline glycine betaine transport system permease component
HVY57_RS19405	COG4175	Glycine betaine
HVY57_RS19410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY57_RS19415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY57_RS19425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY57_RS19430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY57_RS19440	COG4575	ribosome binding
HVY57_RS19460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY57_RS19465	COG0640	Transcriptional regulator
HVY57_RS19470	COG0401	homolog of Blt101
HVY57_RS19475	COG1652	LysM domain
HVY57_RS19480	COG1802	Transcriptional regulator
HVY57_RS19485	COG1113	amino acid transport
HVY57_RS19490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY57_RS19495	COG1012	belongs to the aldehyde dehydrogenase family
HVY57_RS19500	COG0579	oxidoreductase
HVY57_RS19520	COG0583	DNA-binding transcription factor activity
HVY57_RS19530	COG0666	response to abiotic stimulus
HVY57_RS19540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY57_RS19545	COG1304	FMN binding
HVY57_RS19550	COG0549	Belongs to the carbamate kinase family
HVY57_RS19555	COG0402	S-adenosylhomocysteine deaminase activity
HVY57_RS19560	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVY57_RS19570	COG1064	alcohol dehydrogenase
HVY57_RS19575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY57_RS19580	COG0698	ribose 5-phosphate isomerase
HVY57_RS19590	COG2376	Dihydroxyacetone kinase
HVY57_RS19595	COG0149	triose-phosphate isomerase activity
HVY57_RS19600	COG1082	Xylose isomerase domain protein TIM barrel
HVY57_RS19605	COG2084	Dehydrogenase
HVY57_RS19610	COG2390	Transcriptional regulator
HVY57_RS19615	COG0393	Putative heavy-metal-binding
HVY57_RS19675	COG0582	viral genome integration into host DNA
HVY57_RS19690	COG2867	negative regulation of translational initiation
HVY57_RS19700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY57_RS19705	COG0497	DNA recombination
HVY57_RS19720	COG4536	flavin adenine dinucleotide binding
HVY57_RS19725	COG4137	Cytochrome C assembly protein
HVY57_RS19730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVY57_RS19760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY57_RS19765	COG0287	Prephenate dehydrogenase
HVY57_RS19765	COG1605	Chorismate mutase
HVY57_RS19770	COG0077	Prephenate dehydratase
HVY57_RS19770	COG1605	Chorismate mutase
HVY57_RS19780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY57_RS19785	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY57_RS19790	COG0564	pseudouridine synthase activity
HVY57_RS19800	COG0542	response to heat
HVY57_RS19825	COG0477	Major facilitator Superfamily
HVY57_RS19830	COG5544	Lipoprotein
HVY57_RS19835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY57_RS19840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY57_RS19840	COG0045	succinate-CoA ligase (ADP-forming) activity
HVY57_RS19840	COG1042	CoA-binding domain protein
HVY57_RS19850	COG3118	belongs to the thioredoxin family
HVY57_RS19855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY57_RS19880	COG0513	Belongs to the DEAD box helicase family
HVY57_RS19890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY57_RS19900	COG1595	DNA-templated transcription, initiation
HVY57_RS19905	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVY57_RS19910	COG3026	antisigma factor binding
HVY57_RS19915	COG3086	response to oxidative stress
HVY57_RS19925	COG0681	Belongs to the peptidase S26 family
HVY57_RS19945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVY57_RS19960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY57_RS19965	COG1737	Transcriptional regulator
HVY57_RS19970	COG0560	Phosphoserine phosphatase
HVY57_RS19985	COG0047	phosphoribosylformylglycinamidine synthase activity
HVY57_RS19985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVY57_RS19990	COG2205	protein histidine kinase activity
HVY57_RS19995	COG3170	Tfp pilus assembly protein FimV
HVY57_RS20000	COG2204	response regulator
HVY57_RS20005	COG0347	Belongs to the P(II) protein family
HVY57_RS20025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY57_RS20040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY57_RS20040	COG4651	solute:proton antiporter activity
HVY57_RS20045	COG2223	nitrite transmembrane transporter activity
HVY57_RS20050	COG0737	Belongs to the 5'-nucleotidase family
HVY57_RS20055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY57_RS20060	COG3735	TraB family
HVY57_RS20070	COG2217	Heavy metal translocating P-type atpase
HVY57_RS20075	COG0531	amino acid
HVY57_RS20100	COG0789	Transcriptional regulator
HVY57_RS20105	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY57_RS20110	COG0330	HflC and HflK could
HVY57_RS20115	COG4619	ABC transporter
HVY57_RS20120	COG0390	transport system, permease component
HVY57_RS20125	COG3118	belongs to the thioredoxin family
HVY57_RS20130	COG0300	oxidoreductase activity
HVY57_RS20135	COG2755	lipolytic protein G-D-S-L family
HVY57_RS20140	COG4181	ATPase activity
HVY57_RS20145	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVY57_RS20150	COG3157	Type VI secretion system effector, Hcp
HVY57_RS20170	COG0549	Belongs to the carbamate kinase family
HVY57_RS20175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVY57_RS20180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVY57_RS20190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY57_RS20200	COG1988	membrane-bound metal-dependent
HVY57_RS20205	COG2501	S4 domain
HVY57_RS20220	COG1017	nitric oxide dioxygenase activity
HVY57_RS20220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY57_RS20230	COG2259	Doxx family
HVY57_RS20240	COG2814	Major facilitator Superfamily
HVY57_RS20245	COG3711	transcriptional antiterminator
HVY57_RS20250	COG1073	alpha beta
HVY57_RS20255	COG0483	inositol monophosphate 1-phosphatase activity
HVY57_RS20275	COG0822	iron-sulfur transferase activity
HVY57_RS20295	COG0633	Ferredoxin
HVY57_RS20300	COG2975	iron-sulfur cluster assembly
HVY57_RS20315	COG2897	thiosulfate sulfurtransferase activity
HVY57_RS20320	COG2373	Large extracellular alpha-helical protein
HVY57_RS20325	COG4953	penicillin-binding protein 1C
HVY57_RS20355	COG2976	Protein conserved in bacteria
HVY57_RS20370	COG1645	bacterial-type flagellum-dependent swarming motility
HVY57_RS20395	COG0516	GMP reductase activity
HVY57_RS20395	COG0517	IMP dehydrogenase activity
HVY57_RS20410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY57_RS20450	COG3039	Transposase
HVY57_RS20460	COG0248	Ppx GppA phosphatase
HVY57_RS20470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVY57_RS20485	COG2233	PERMEase
HVY57_RS20495	COG1393	Belongs to the ArsC family
HVY57_RS20500	COG4783	chaperone-mediated protein folding
HVY57_RS20505	COG0628	permease
HVY57_RS20510	COG3604	Transcriptional regulator
HVY57_RS20520	COG3260	NADH ubiquinone oxidoreductase 20
HVY57_RS20525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY57_RS20530	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY57_RS20530	COG3261	NADH dehydrogenase
HVY57_RS20540	COG4237	Hydrogenase 4 membrane
HVY57_RS20555	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY57_RS20560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVY57_RS20565	COG2716	regulation of RNA biosynthetic process
HVY57_RS20575	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVY57_RS20590	COG2321	neutral zinc metallopeptidase
HVY57_RS20600	COG0400	carboxylic ester hydrolase activity
HVY57_RS20615	COG1393	Belongs to the ArsC family
HVY57_RS20625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY57_RS20630	COG3850	Histidine kinase
HVY57_RS20635	COG0493	'glutamate synthase
HVY57_RS20635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY57_RS20645	COG5342	invasion associated locus B
HVY57_RS20650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY57_RS20655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY57_RS20660	COG0280	phosphate acetyltransferase
HVY57_RS20660	COG0281	malic enzyme
HVY57_RS20680	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY57_RS20700	COG2837	iron assimilation
HVY57_RS20705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY57_RS20710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY57_RS20710	COG1263	PTS System
HVY57_RS20725	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS20730	COG4150	thiosulfate binding
HVY57_RS20735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVY57_RS20740	COG4208	sulfate ABC transporter
HVY57_RS20745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVY57_RS20750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY57_RS20765	COG2190	(PTS) system
HVY57_RS20770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY57_RS20775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS20780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY57_RS20790	COG3115	cell septum assembly
HVY57_RS20800	COG3530	Putative quorum-sensing-regulated virulence factor
HVY57_RS20805	COG0385	Bile acid
HVY57_RS20815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVY57_RS20820	COG2211	Major facilitator Superfamily
HVY57_RS20830	COG0583	DNA-binding transcription factor activity
HVY57_RS20855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVY57_RS20860	COG3415	Transposase
HVY57_RS20865	COG3415	Transposase
HVY57_RS20880	COG2200	EAL domain
HVY57_RS20880	COG2199	diguanylate cyclase activity
HVY57_RS20885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY57_RS20910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS20915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY57_RS20920	COG0006	proline dipeptidase activity
HVY57_RS20925	COG1363	Peptidase, m42
HVY57_RS20930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY57_RS20930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS20930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY57_RS20935	COG2207	Transcriptional regulator
HVY57_RS20940	COG3279	Response regulator of the LytR AlgR family
HVY57_RS20945	COG3275	phosphorelay sensor kinase activity
HVY57_RS20950	COG0436	Aminotransferase
HVY57_RS20960	COG1560	Kdo2-lipid A biosynthetic process
HVY57_RS20980	COG0154	amidase activity
HVY57_RS21000	COG4638	Rieske (2fe-2S)
HVY57_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
HVY57_RS21020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY57_RS21040	COG2246	polysaccharide biosynthetic process
HVY57_RS21045	COG0582	viral genome integration into host DNA
HVY57_RS21055	COG2116	formate transmembrane transporter activity
HVY57_RS21065	COG2067	long-chain fatty acid transport protein
HVY57_RS21070	COG3691	Protein conserved in bacteria
HVY57_RS21085	COG2062	phosphohistidine phosphatase, SixA
HVY57_RS21090	COG3539	Fimbrial protein
HVY57_RS21095	COG3188	usher protein
HVY57_RS21100	COG3121	Chaperone
HVY57_RS21105	COG3539	Fimbrial protein
HVY57_RS21110	COG3539	Fimbrial protein
HVY57_RS21115	COG3539	Fimbrial protein
HVY57_RS21145	COG0730	response to heat
HVY57_RS21150	COG3101	peptidyl-lysine hydroxylation
HVY57_RS21165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY57_RS21240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY57_RS21250	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY57_RS21250	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY57_RS21330	COG4695	Portal protein
HVY57_RS21340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HVY57_RS21420	COG4974	Belongs to the 'phage' integrase family
HVY57_RS21430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY57_RS21440	COG0586	Pfam SNARE associated Golgi protein
HVY57_RS21450	COG0285	dihydrofolate synthase activity
HVY57_RS21455	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVY57_RS21460	COG1286	toxin biosynthetic process
HVY57_RS21465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVY57_RS21470	COG0163	prenyltransferase activity
HVY57_RS21475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY57_RS21480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY57_RS21485	COG4215	(ABC) transporter
HVY57_RS21490	COG4160	amino acid transport
HVY57_RS21495	COG4598	ABC transporter
HVY57_RS21500	COG5464	transposase or invertase
HVY57_RS21505	COG1090	epimerase
HVY57_RS21510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY57_RS21515	COG0625	glutathione transferase activity
HVY57_RS21520	COG0625	glutathione transferase activity
HVY57_RS21525	COG0622	Phosphoesterase
HVY57_RS21535	COG1609	Transcriptional regulator
HVY57_RS21550	COG3037	sugar-specific permease SgaT UlaA
HVY57_RS21555	COG3959	Transketolase, thiamine diphosphate binding domain
HVY57_RS21560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVY57_RS21570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVY57_RS21585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY57_RS21590	COG0471	metal ion transport
HVY57_RS21590	COG0490	domain, Protein
HVY57_RS21600	COG0436	Aminotransferase
HVY57_RS21605	COG0583	DNA-binding transcription factor activity
HVY57_RS21625	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVY57_RS21630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVY57_RS21635	COG1034	ATP synthesis coupled electron transport
HVY57_RS21650	COG0839	Belongs to the complex I subunit 6 family
HVY57_RS21660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY57_RS21665	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY57_RS21690	COG2304	oxidoreductase activity
HVY57_RS21695	COG0784	Response regulator, receiver
HVY57_RS21695	COG0835	chemotaxis
HVY57_RS21705	COG2153	protein acetylation
HVY57_RS21710	COG4575	ribosome binding
HVY57_RS21715	COG1169	isochorismate synthase
HVY57_RS21730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVY57_RS21740	COG0318	PFAM AMP-dependent synthetase and ligase
HVY57_RS21810	COG5464	transposase or invertase
HVY57_RS21815	COG0247	lactate metabolic process
HVY57_RS21825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY57_RS21830	COG2271	Major facilitator Superfamily
HVY57_RS21835	COG0584	glycerophosphoryl diester phosphodiesterase
HVY57_RS21845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY57_RS21850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY57_RS21855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY57_RS21860	COG3468	outer membrane autotransporter barrel domain protein
HVY57_RS21870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY57_RS21875	COG0183	Belongs to the thiolase family
HVY57_RS21880	COG2031	fatty acid transporter
HVY57_RS21885	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY57_RS21890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVY57_RS21895	COG2204	response regulator
HVY57_RS21905	COG2205	protein histidine kinase activity
HVY57_RS21905	COG0784	Response regulator, receiver
HVY57_RS21910	COG2197	response regulator
HVY57_RS21915	COG0642	Histidine kinase
HVY57_RS21915	COG2198	Histidine kinase
HVY57_RS21920	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY57_RS21925	COG1477	protein flavinylation
HVY57_RS21930	COG2169	Transcriptional regulator
HVY57_RS21930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY57_RS21935	COG3145	DNA-N1-methyladenine dioxygenase activity
HVY57_RS21940	COG4615	Cyclic peptide transporter
HVY57_RS21950	COG1126	abc transporter atp-binding protein
HVY57_RS21955	COG0765	amino acid transport
HVY57_RS21960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY57_RS21970	COG5006	permease, DMT superfamily
HVY57_RS21975	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVY57_RS21980	COG2194	sulfuric ester hydrolase activity
HVY57_RS21990	COG1321	iron dependent repressor
HVY57_RS21995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY57_RS22000	COG1376	ErfK ybiS ycfS ynhG family protein
HVY57_RS22005	COG0488	(ABC) transporter
HVY57_RS22010	COG0561	phosphatase activity
HVY57_RS22015	COG1882	Formate acetyltransferase
HVY57_RS22020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY57_RS22025	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY57_RS22030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY57_RS22035	COG0303	'Molybdopterin
HVY57_RS22060	COG2200	EAL domain
HVY57_RS22065	COG2199	diguanylate cyclase activity
HVY57_RS22080	COG2133	pyrroloquinoline quinone binding
HVY57_RS22085	COG0625	glutathione transferase activity
HVY57_RS22090	COG1686	Belongs to the peptidase S11 family
HVY57_RS22095	COG1349	DNA-binding transcription factor activity
HVY57_RS22100	COG0671	phosphoesterase, PA-phosphatase related
HVY57_RS22105	COG2814	Major facilitator Superfamily
HVY57_RS22115	COG0561	phosphatase activity
HVY57_RS22120	COG0738	Major facilitator superfamily
HVY57_RS22125	COG3226	Transcriptional regulator
HVY57_RS22145	COG0778	Nitroreductase
HVY57_RS22160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY57_RS22165	COG3842	ATPase activity
HVY57_RS22170	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY57_RS22175	COG1177	transmembrane transport
HVY57_RS22190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY57_RS22195	COG4160	amino acid transport
HVY57_RS22200	COG4215	(ABC) transporter
HVY57_RS22205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY57_RS22210	COG1126	abc transporter atp-binding protein
HVY57_RS22225	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY57_RS22230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY57_RS22235	COG0702	epimerase
HVY57_RS22240	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVY57_RS22245	COG0028	Belongs to the TPP enzyme family
HVY57_RS22255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY57_RS22265	COG2431	L-lysine efflux transmembrane transporter activity
HVY57_RS22280	COG3593	DNA synthesis involved in DNA repair
HVY57_RS22285	COG2990	Protein conserved in bacteria
HVY57_RS22290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY57_RS22300	COG1278	Cold shock
HVY57_RS22310	COG0542	response to heat
HVY57_RS22330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVY57_RS22335	COG4988	ABC transporter
HVY57_RS22340	COG0492	ferredoxin-NADP+ reductase activity
HVY57_RS22345	COG1522	sequence-specific DNA binding
HVY57_RS22350	COG1674	ftsk spoiiie
HVY57_RS22350	COG1178	ABC-type Fe3 transport system permease component
HVY57_RS22360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVY57_RS22370	COG1335	isochorismatase
HVY57_RS22380	COG0531	amino acid
HVY57_RS22390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY57_RS22395	COG4974	Belongs to the 'phage' integrase family
HVY57_RS22495	COG1192	Involved in chromosome partitioning
HVY57_RS22585	COG0210	DNA helicase
HVY57_RS22730	COG4245	von Willebrand factor, type A
HVY57_RS22735	COG4245	von Willebrand factor, type A
HVY57_RS22765	COG1358	cellular component organization or biogenesis
HVY57_RS22845	COG3550	peptidyl-serine autophosphorylation
HVY57_RS22880	COG0786	glutamate:sodium symporter activity
HVY57_RS22895	COG0640	Transcriptional regulator
HVY57_RS23020	COG4221	oxidoreductase activity
HVY57_RS23140	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY57_RS23170	COG0739	heme binding
HVY57_RS23180	COG2132	Multicopper oxidase
HVY57_RS23185	COG3667	copper resistance
HVY57_RS23190	COG2372	response to copper ion
HVY57_RS23195	COG1276	copper resistance
HVY57_RS23200	COG0745	RESPONSE REGULATOR receiver
HVY57_RS23205	COG2205	protein histidine kinase activity
HVY57_RS23290	COG0697	spore germination
HVY57_RS23400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HVY57_RS23400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY57_RS23420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY57_RS23580	COG3385	transposase activity
HVY57_RS23805	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY57_RS23840	COG2026	Addiction module toxin, RelE StbE family
HVY57_RS23960	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVY57_RS23990	COG0305	Participates in initiation and elongation during chromosome replication
HVY57_RS24245	COG2132	Multicopper oxidase
HVY57_RS24295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY57_RS24300	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY57_RS24315	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY57_RS24365	COG3133	Outer membrane lipoprotein