locus-tag class description HVY75_RS00025 ENOG4105ED4 portal protein HVY75_RS00115 ENOG410685N tail fiber protein HVY75_RS00120 ENOG4105UZW Tail fiber assembly protein HVY75_RS00170 ENOG4105ZTC transcriptional activator, Ogr delta HVY75_RS00175 ENOG4105C6N Formate acetyltransferase HVY75_RS00180 ENOG4105TMB Formate nitrite transporter HVY75_RS00185 ENOG4105DDY UPF0142 protein ycaO HVY75_RS00190 ENOG4107VMU Membrane HVY75_RS00210 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVY75_RS00220 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVY75_RS00225 ENOG4105BZ1 (ABC) transporter HVY75_RS00235 ENOG4105T0Z Conserved Protein HVY75_RS00250 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVY75_RS00255 ENOG4107S90 membrAne HVY75_RS00260 ENOG4106371 Methyltransferase HVY75_RS00270 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVY75_RS00280 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVY75_RS00285 ENOG4105EAQ (twin-arginine translocation) pathway signal HVY75_RS00290 ENOG4105C5X domain protein HVY75_RS00295 ENOG4105CGF Aromatic amino acid aminotransferase HVY75_RS00300 ENOG4105FCK Membrane HVY75_RS00315 ENOG4105CD8 aminopeptidase N HVY75_RS00320 ENOG4105E2Y ABC, transporter HVY75_RS00325 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVY75_RS00335 ENOG4105GVF (ABC) transporter HVY75_RS00340 ENOG4108UZX fmn reductase HVY75_RS00350 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVY75_RS00355 ENOG4105QVC MOSC domain-containing protein HVY75_RS00365 ENOG4105C5H ABC transporter HVY75_RS00370 ENOG4105F1S paraquat-inducible protein a HVY75_RS00375 ENOG4105DY2 Paraquat-inducible protein b HVY75_RS00380 ENOG4108Q2G (LipO)protein HVY75_RS00385 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVY75_RS00395 ENOG4105DAN ATP-dependent protease HVY75_RS00415 ENOG4108RZ1 DNA transformation protein HVY75_RS00420 ENOG4105EM2 membrane HVY75_RS00425 ENOG410901E Membrane HVY75_RS00430 ENOG41088T4 Helicase IV HVY75_RS00445 ENOG4105K4P CoA-binding domain protein HVY75_RS00460 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVY75_RS00465 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVY75_RS00470 ENOG4108MN8 Membrane HVY75_RS00485 ENOG4105E3S small subunit HVY75_RS00490 ENOG4105DPX Hydrogenase, large subunit HVY75_RS00495 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVY75_RS00500 ENOG4108USZ hydrogenase HVY75_RS00505 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVY75_RS00510 ENOG4105MVP hydrogenase-1 operon protein HyaF HVY75_RS00515 ENOG4106RHG Yeca family HVY75_RS00520 ENOG4105E0U tyrosine-specific transport protein HVY75_RS00525 ENOG4105VVZ metal-binding protein HVY75_RS00530 ENOG41090A1 ferritin HVY75_RS00535 ENOG4105P23 (LipO)protein HVY75_RS00540 ENOG4108UEC Ferritin-like protein HVY75_RS00545 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVY75_RS00550 ENOG4105C2J ABC transporter HVY75_RS00555 ENOG4105CNN ABC, transporter HVY75_RS00560 ENOG4108K4C ec 3.1.3.12 HVY75_RS00570 ENOG4108VA4 Universal stress protein HVY75_RS00580 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVY75_RS00585 ENOG4107RD7 Flagellar Motor Protein, MotA HVY75_RS00590 ENOG4105ER2 Ompa motb domain protein HVY75_RS00595 ENOG4105CBS Chea signal transduction histidine kinase HVY75_RS00600 ENOG4108V3W Chemotaxis protein, CheW HVY75_RS00630 ENOG4105C8Q Methyl-accepting chemotaxis HVY75_RS00635 ENOG4105BZU Histidine kinase HVY75_RS00645 ENOG4108VYJ response regulator receiver protein HVY75_RS00670 ENOG4105MWK D-amino acid dehydrogenase, small subunit HVY75_RS00675 ENOG4105RQF LysR family Transcriptional regulator HVY75_RS00685 ENOG4105D6F Phosphatase HVY75_RS00690 ENOG4105XH3 HVY75_RS00700 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVY75_RS00705 ENOG4108R86 Transcriptional regulator HVY75_RS00710 ENOG4105BZU Histidine kinase HVY75_RS00715 ENOG41064RH membrane protein YliF HVY75_RS00720 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY75_RS00725 ENOG4107EEX Cellulose synthase regulator protein HVY75_RS00735 ENOG41066VF YeeE YedE family protein HVY75_RS00740 ENOG4108W9D (LipO)protein HVY75_RS00745 ENOG4105E5K Alpha-amylase HVY75_RS00750 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HVY75_RS00755 ENOG4105MQ3 flagellar protein FliS HVY75_RS00760 ENOG4105DTS flagellar hook-associated HVY75_RS00770 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY75_RS00775 ENOG4108M9K flagella biosynthesis protein FliZ HVY75_RS00780 ENOG4105EAB amino acid AbC transporter HVY75_RS00790 ENOG4105E5Q amino acid AbC transporter HVY75_RS00795 ENOG4105CDA abc transporter atp-binding protein HVY75_RS00800 ENOG4105VJY transcriptional regulator HVY75_RS00805 ENOG4105XVG cytoplasmic protein HVY75_RS00810 ENOG4105WH1 Two component transcriptional regulator luxr family HVY75_RS00840 ENOG4107SVH Potassium channel protein HVY75_RS00845 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY75_RS00850 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY75_RS00865 ENOG4105BZU Histidine kinase HVY75_RS00870 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVY75_RS00875 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVY75_RS00880 ENOG4105CUW cytochrome C-TYPE protein HVY75_RS00885 ENOG4107QY8 reductase HVY75_RS00895 ENOG4105D00 flagellar biosynthetic protein flhB HVY75_RS00900 ENOG4105D7B Flagellar biosynthesis protein flha HVY75_RS00905 ENOG4105W13 flagellar protein HVY75_RS00915 ENOG4106ZCM YecM protein HVY75_RS00935 ENOG4105WJG Glutathione HVY75_RS00940 ENOG41081XQ Conserved Protein HVY75_RS00945 ENOG4105D3W isochorismatase HVY75_RS00955 ENOG4108TIT dATP pyrophosphohydrolase HVY75_RS00960 ENOG4105CDY transcriptional regulatory protein HVY75_RS00970 ENOG4107S01 Repressor protein MetJ HVY75_RS00990 ENOG4105FAV ABC, transporter HVY75_RS01000 ENOG4105NXV High-affinity zinc uptake system protein HVY75_RS01005 ENOG4105DR5 peptidase HVY75_RS01010 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVY75_RS01015 ENOG4105CA9 Pyruvate kinase HVY75_RS01020 ENOG4106KNT transcriptional regulator HVY75_RS01025 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVY75_RS01030 ENOG4105C01 Dihydroxy-acid dehydratase HVY75_RS01035 ENOG4108UHU Aldolase HVY75_RS01040 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HVY75_RS01045 ENOG4105X2V dna damage-inducible protein HVY75_RS01055 ENOG4108Q2J Inner membrane protein YebE HVY75_RS01060 ENOG4105CUG Oligopeptidase b HVY75_RS01065 ENOG4105UMD exodeoxyribonuclease X HVY75_RS01070 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY75_RS01075 ENOG4105MPK DNA polymerase III subunit theta HVY75_RS01080 ENOG4105FXM Copper resistance protein HVY75_RS01085 ENOG4108PNC copper resistance HVY75_RS01090 ENOG4105NKT exported protein HVY75_RS01095 ENOG4108R1E Serine threonine protein phosphatase 1 HVY75_RS01100 ENOG4105UVW uncharacterized protein yebW HVY75_RS01105 ENOG4105WT8 Protein of unknown function (DUF1480) HVY75_RS01115 ENOG4105DY2 Paraquat-inducible protein b HVY75_RS01120 ENOG4105H2K paraquat-inducible protein a HVY75_RS01125 ENOG4108ZGC gaf domain protein HVY75_RS01135 ENOG4105CN1 protease HVY75_RS01145 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY75_RS01150 ENOG4105J4Q Transcriptional regulator HVY75_RS01155 ENOG4105TIK HVY75_RS01165 ENOG4105Q3Y exported protein HVY75_RS01180 ENOG4105DHI Methyltransferase HVY75_RS01195 ENOG4105F3R pts system mannose fructose sorbose family iid HVY75_RS01200 ENOG4105ETZ PTS System HVY75_RS01205 ENOG4105DAS pts system HVY75_RS01210 ENOG4105EE5 Membrane protein terC HVY75_RS01215 ENOG4107XTP (EAL) domain protein HVY75_RS01220 ENOG4105EJQ L-serine dehydratase HVY75_RS01230 ENOG4105CRQ synthase (Component I) HVY75_RS01245 ENOG4105V2F Uncharacterized protein yoac HVY75_RS01250 ENOG4105M4H endoribonuclease L-psp HVY75_RS01265 ENOG4105DVT helicase HVY75_RS01270 ENOG41072GX Peptidase M22 Glycoprotease HVY75_RS01275 ENOG4105Y4Z Outer Membrane Lipoprotein HVY75_RS01280 ENOG4105CEY Amp-dependent synthetase and ligase HVY75_RS01285 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVY75_RS01290 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY75_RS01295 ENOG4108JA2 transcriptioN-repair coupling factor HVY75_RS01300 ENOG4105IQC Inner membrane protein YcfT HVY75_RS01305 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY75_RS01310 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVY75_RS01315 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY75_RS01325 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVY75_RS01340 ENOG4107RUE extracellular solute-binding protein family 1 HVY75_RS01345 ENOG4105D38 putrescine abc transporter HVY75_RS01365 ENOG4105DSB aldose 1-epimerase HVY75_RS01380 ENOG4105VUT cytoplasmic protein HVY75_RS01385 ENOG4108RWI nicotinamidase HVY75_RS01390 ENOG4105HDK L-asparaginase HVY75_RS01400 ENOG4105D07 Signal peptide peptidase, SppA HVY75_RS01405 ENOG41069NU Nitroreductase HVY75_RS01415 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY75_RS01420 ENOG4105F7F Chaperone HVY75_RS01430 ENOG4105D82 Glutamate dehydrogenase HVY75_RS01435 ENOG4105MTM Protein of unknown function (DUF1496) HVY75_RS01440 ENOG4105M6F mutator MutT protein HVY75_RS01445 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVY75_RS01450 ENOG4107RM6 sulfurtransferase HVY75_RS01455 ENOG4108VGW abc transporter atp-binding protein HVY75_RS01460 ENOG4105CXZ ABC transporter, permease HVY75_RS01465 ENOG4105VNH ABC transporter solute-binding protein HVY75_RS01470 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY75_RS01475 ENOG4108N5C SNARE associated Golgi protein-related protein HVY75_RS01480 ENOG4108RSN SNARE associated Golgi HVY75_RS01485 ENOG4105CGK Exodeoxyribonuclease III HVY75_RS01515 ENOG4108SPG Periplasmic Protein HVY75_RS01525 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVY75_RS01535 ENOG4105KKI DNA-binding transcriptional activator OsmE HVY75_RS01540 ENOG4105VZJ PTS System HVY75_RS01545 ENOG4105CK1 PTS System HVY75_RS01550 ENOG4105VCP PTS System HVY75_RS01555 ENOG4105EZV Transcriptional regulator HVY75_RS01560 ENOG4105F8D glycoside hydrolase family 4 HVY75_RS01570 ENOG4105CH6 catalase HVY75_RS01575 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HVY75_RS01580 ENOG4108ETY sodium dicarboxylate symporter HVY75_RS01585 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVY75_RS01590 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVY75_RS01595 ENOG4107PN8 YfeABCD locus regulator HVY75_RS01605 ENOG4105P10 Uncharacterized protein ydiZ HVY75_RS01610 ENOG4105DE4 1-phosphofructokinase HVY75_RS01615 ENOG4108NE3 Salt-induced outer membrane protein HVY75_RS01630 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVY75_RS01635 ENOG41082NX 50s ribosomal protein l35 HVY75_RS01670 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HVY75_RS01675 ENOG4108QBX (LipO)protein HVY75_RS01695 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY75_RS01705 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVY75_RS01710 ENOG4105SUA Ydil protein HVY75_RS01720 ENOG4105IPI Membrane HVY75_RS01725 ENOG4105CQB FAD linked oxidase domain protein HVY75_RS01730 ENOG4105KA0 thioesterase Superfamily protein HVY75_RS01735 ENOG410671Z uncharacterized protein ydiH HVY75_RS01740 ENOG4108Z4V iron-sulfur cluster assembly HVY75_RS01745 ENOG4105DIW FeS assembly protein SUFB HVY75_RS01750 ENOG4105C3K feS assembly ATPase SufC HVY75_RS01755 ENOG4105JRK feS assembly protein SufD HVY75_RS01770 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY75_RS01775 ENOG4105KMX major outer membrane lipoprotein HVY75_RS01780 ENOG4105CA9 Pyruvate kinase HVY75_RS01790 ENOG4105RFR Protein of unknown function (DUF2767) HVY75_RS01795 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVY75_RS01800 ENOG4105N0V mono-oxygenase ydhR HVY75_RS01820 ENOG4108R6K riboflavin synthase, subunit alpha HVY75_RS01825 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVY75_RS01830 ENOG4105CZQ inner membrane transport protein YdhC HVY75_RS01835 ENOG4105F52 Transcriptional regulator HVY75_RS01850 ENOG4105F27 Major Facilitator HVY75_RS01855 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY75_RS01860 ENOG4105K4H Nlp p60 protein HVY75_RS01865 ENOG4105M2J Glutaredoxin HVY75_RS01870 ENOG4107QRT dEAD DEAH box helicase HVY75_RS01875 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HVY75_RS01880 ENOG4108UYE Lactoylglutathione lyase HVY75_RS01885 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY75_RS01890 ENOG4108WUH Transcriptional regulator, TetR family HVY75_RS01895 ENOG4105XZD Fe-S protein HVY75_RS01900 ENOG4107RGM aldo keto reductase HVY75_RS01905 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY75_RS01910 ENOG4105DSW Fusaric acid resistance protein HVY75_RS01915 ENOG4105Y49 secretion protein, HlyD family HVY75_RS01930 ENOG4108XTF Outer Membrane Lipoprotein HVY75_RS01940 ENOG410642K Lysozyme inhibitor HVY75_RS01955 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVY75_RS01960 ENOG4108K3A Glutathione S-transferase HVY75_RS01965 ENOG4105DUX Transporter HVY75_RS01970 ENOG4105CSM endonuclease III HVY75_RS01980 ENOG4108UQQ Electron transport complex HVY75_RS02005 ENOG4105M9B inner membrane protein ydgK HVY75_RS02010 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVY75_RS02015 ENOG4106C6R beta-lactam resistance protein HVY75_RS02020 ENOG4105D9R oxidoreductase HVY75_RS02030 ENOG4105C87 Aminotransferase class I and II HVY75_RS02035 ENOG4106J39 exported protein HVY75_RS02040 ENOG4105EIP mannose-6-phosphate isomerase HVY75_RS02045 ENOG4107GFK fumarate HVY75_RS02050 ENOG4105C9Q fumarate hydratase class II HVY75_RS02060 ENOG4105JJR Histidine kinase HVY75_RS02065 ENOG4107EXC regulatoR HVY75_RS02070 ENOG4105RA2 Membrane HVY75_RS02080 ENOG4105D5Q Arginine ornithine antiporter HVY75_RS02085 ENOG4105C5D exported protein HVY75_RS02090 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY75_RS02095 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY75_RS02100 ENOG4105BZU Histidine kinase HVY75_RS02105 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVY75_RS02120 ENOG4105D94 Major Facilitator Superfamily HVY75_RS02125 ENOG4106NZI LysR family Transcriptional regulator HVY75_RS02130 ENOG4105DAG ROK family HVY75_RS02135 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY75_RS02140 ENOG4105CMQ Chloride channel HVY75_RS02145 ENOG4108IJ8 ABC transporter HVY75_RS02150 ENOG4105E90 ABC transporter HVY75_RS02155 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVY75_RS02160 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HVY75_RS02165 ENOG4105R71 cytoplasmic protein HVY75_RS02170 ENOG4108T9Y Inner membrane protein ydcZ HVY75_RS02175 ENOG4108Z7F N-acetyltransferase HVY75_RS02180 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVY75_RS02185 ENOG4108WYP Transcriptional regulator HVY75_RS02190 ENOG4105CHB tonB-dependent Receptor HVY75_RS02195 ENOG4108NS2 receptor HVY75_RS02200 ENOG4105C85 amino acid HVY75_RS02205 ENOG4108N27 Glutathione S-transferase HVY75_RS02225 ENOG410600T transposase HVY75_RS02290 ENOG4105JAB phenazine biosynthesis protein, phzf family HVY75_RS02295 ENOG4105DIA mandelate racemase muconate lactonizing HVY75_RS02310 ENOG4108MEJ flavin reductase domain protein HVY75_RS02315 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVY75_RS02320 ENOG4107HP6 Transcriptional regulator HVY75_RS02325 ENOG4105DTQ mandelate racemase muconate lactonizing HVY75_RS02330 ENOG4105NN7 muconolactone delta-isomerase HVY75_RS02335 ENOG410626B catechol 1,2-dioxygenase HVY75_RS02370 ENOG4105RPH Inner membrane protein YddG HVY75_RS02380 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY75_RS02385 ENOG4108MG3 formate dehydrogenase HVY75_RS02390 ENOG41084S7 Plasmid maintenance system antidote protein HVY75_RS02400 ENOG4105DQ4 alcohol dehydrogenase HVY75_RS02410 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVY75_RS02415 ENOG4105TPS biofilm-dependent modulation protein HVY75_RS02420 ENOG4108Z9K Osmotically inducible protein HVY75_RS02430 ENOG4105DDW LysR family Transcriptional regulator HVY75_RS02435 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HVY75_RS02440 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HVY75_RS02445 ENOG4105E32 cytoplasmic protein HVY75_RS02455 ENOG4105Z2P Protein of unknown function (DUF465) HVY75_RS02460 ENOG4108Z9I -acetyltransferase HVY75_RS02465 ENOG4107WE3 acetyltransferase YdcK HVY75_RS02470 ENOG41088CC tellurite resistance protein tehB HVY75_RS02475 ENOG4108KKZ (LipO)protein HVY75_RS02480 ENOG4105CFP Peptidase U32 HVY75_RS02490 ENOG4105RR0 Protein of unknown function (DUF2554) HVY75_RS02495 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY75_RS02500 ENOG4107TYH extracellular solute-binding protein family 1 HVY75_RS02505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY75_RS02510 ENOG4105D81 ABC transporter, permease HVY75_RS02515 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVY75_RS02530 ENOG410654E Membrane HVY75_RS02535 ENOG4105KBG Protein of unknown function (DUF1161) HVY75_RS02545 ENOG4108MK9 spermidine N(1)-acetyltransferase HVY75_RS02560 ENOG4105CXK mandelate racemase muconate lactonizing HVY75_RS02565 ENOG4105CPQ Dehydrogenase HVY75_RS02570 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVY75_RS02580 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY75_RS02585 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVY75_RS02590 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY75_RS02600 ENOG4105DEI Mannitol dehydrogenase HVY75_RS02605 ENOG41061EV selenium-binding protein YdfZ HVY75_RS02610 ENOG4107XBN GntR Family Transcriptional Regulator HVY75_RS02615 ENOG4105EMU Dehydrogenase HVY75_RS02620 ENOG4105DGW oligopeptidase A HVY75_RS02625 ENOG4108WTK competence damage-inducible protein HVY75_RS02630 ENOG4108YDI single-species biofilm formation on inanimate substrate HVY75_RS02635 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVY75_RS02640 ENOG4105E5W Transporter HVY75_RS02645 ENOG4108594 Permease of the drug metabolite transporter HVY75_RS02650 ENOG4106DNR multiple antibiotic resistance protein HVY75_RS02655 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVY75_RS02660 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVY75_RS02675 ENOG4105EGI Transcriptional regulator HVY75_RS02680 ENOG4105C26 Dehydrogenase HVY75_RS02685 ENOG4105CSV Glutaminase HVY75_RS02690 ENOG4105M0C cytoplasmic protein HVY75_RS02695 ENOG4105BZU Histidine kinase HVY75_RS02705 ENOG4105FFC UPF0187 protein HVY75_RS02715 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVY75_RS02735 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HVY75_RS02740 ENOG4105C2J ABC transporter HVY75_RS02750 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HVY75_RS02760 ENOG4108R6W Transcriptional regulator, ARAC family HVY75_RS02765 ENOG4106PHM regulatory protein HVY75_RS02780 ENOG4105CQ0 ABC transporter HVY75_RS02785 ENOG4105PE1 Receptor HVY75_RS02790 ENOG4107RAN Peptidase, M16 HVY75_RS02795 ENOG4105CVK Glutamate decarboxylase HVY75_RS02800 ENOG4105E5D amino acid HVY75_RS02805 ENOG4105F32 YngK protein HVY75_RS02810 ENOG4105BZU Histidine kinase HVY75_RS02815 ENOG4105BZU Histidine kinase HVY75_RS02830 ENOG4105CPW cytochrome b561 HVY75_RS02835 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVY75_RS02840 ENOG4107DB1 DUF218 domain HVY75_RS02850 ENOG4105CQ7 ATP-dependent helicase HVY75_RS02860 ENOG41077RS Phosphatase HVY75_RS02865 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVY75_RS02870 ENOG4108HPI phosphatidate Cytidylyltransferase HVY75_RS02875 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVY75_RS02885 ENOG4107S5I aldo keto reductase HVY75_RS02890 ENOG4108Z0R Transferase HVY75_RS02895 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVY75_RS02900 ENOG4105DZS Phenylacetate-CoA ligase HVY75_RS02905 ENOG4105CHU acetyl-coa acetyltransferase HVY75_RS02910 ENOG4108ZJI phenylacetic acid degradation protein HVY75_RS02915 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVY75_RS02920 ENOG4108UKI Enoyl-CoA hydratase HVY75_RS02925 ENOG4105E39 Enoyl-CoA hydratase HVY75_RS02930 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY75_RS02935 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVY75_RS02940 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVY75_RS02945 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVY75_RS02950 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVY75_RS02955 ENOG4105DXM phenylacetic acid degradation protein HVY75_RS02960 ENOG4105F11 amine oxidase HVY75_RS02965 ENOG4105C26 Dehydrogenase HVY75_RS02980 ENOG4105WXT Conserved Protein HVY75_RS02985 ENOG410689M (LipO)protein HVY75_RS02990 ENOG4107H52 Dicarboxylate transport HVY75_RS02995 ENOG4105C5I Dehydrogenase HVY75_RS03000 ENOG41090X5 Heat shock protein hslJ HVY75_RS03005 ENOG4105IKK cytoplasmic protein HVY75_RS03015 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVY75_RS03020 ENOG4105FCK Membrane HVY75_RS03025 ENOG4108RW8 Universal stress protein F HVY75_RS03035 ENOG4105C1J atp-dependent rna helicase HVY75_RS03050 ENOG4105BZU Histidine kinase HVY75_RS03055 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HVY75_RS03060 ENOG4105F2Z 3-oxoadipate enol-lactonase HVY75_RS03065 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HVY75_RS03070 ENOG4105CHU acetyl-coa acetyltransferase HVY75_RS03075 ENOG4107QNJ CoA-transferase subunit B HVY75_RS03085 ENOG4107HP6 Transcriptional regulator HVY75_RS03090 ENOG4108DG9 Smr protein MutS2 HVY75_RS03095 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY75_RS03100 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVY75_RS03105 ENOG4105Q9Y Universal stress protein HVY75_RS03110 ENOG4105S5I Membrane HVY75_RS03115 ENOG4105D64 Mechanosensitive ion channel HVY75_RS03120 ENOG4107QSI ABC, transporter HVY75_RS03125 ENOG4105KXI murein peptide amidase A HVY75_RS03130 ENOG4107S8C mandelate racemase muconate lactonizing HVY75_RS03135 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVY75_RS03140 ENOG4108JU8 Transcriptional regulator HVY75_RS03150 ENOG4105CM6 amino acid regulated cytosolic protein HVY75_RS03155 ENOG4105FKQ transcriptional regulator HVY75_RS03160 ENOG4107EFV Outer membrane protein G HVY75_RS03165 ENOG4108IJ9 (ABC) transporter HVY75_RS03170 ENOG4107URF beta-phospho-glucomutase HVY75_RS03175 ENOG4105C71 hydrolase family 65, central catalytic HVY75_RS03180 ENOG4105CK5 oxidoreductase HVY75_RS03185 ENOG4107TYA transient receptor potential locus HVY75_RS03190 ENOG4107RRD Dehydrogenase HVY75_RS03195 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HVY75_RS03200 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HVY75_RS03205 ENOG4105WEM extracellular solute-binding protein HVY75_RS03210 ENOG4107QW3 Sucrose phosphorylase HVY75_RS03215 ENOG4105K8Z Phage shock protein HVY75_RS03220 ENOG4105NNG Peripheral inner membrane phage-shock protein HVY75_RS03225 ENOG4105FM1 phage shock protein C HVY75_RS03230 ENOG4105YYT phage shock protein B HVY75_RS03235 ENOG41087YS Phage shock protein A HVY75_RS03240 ENOG4105E51 psp operon transcriptional activator HVY75_RS03245 ENOG4108HIY periplasmic HVY75_RS03250 ENOG4108I5W peptide transport system, permease protein HVY75_RS03255 ENOG4108EU3 peptide transport system, permease HVY75_RS03260 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVY75_RS03265 ENOG4108JQ2 peptide transport system atp-binding protein HVY75_RS03270 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVY75_RS03275 ENOG4105Q4T oxidoreductase HVY75_RS03285 ENOG4105BZU Histidine kinase HVY75_RS03295 ENOG4105N2W Transcriptional regulator HVY75_RS03305 ENOG4108ZJT translation initiation factor, Sui1 HVY75_RS03315 ENOG4105CFV Tetratricopeptide repeat protein HVY75_RS03320 ENOG4105Q4A inner membrane protein yciS HVY75_RS03325 ENOG4105EYK Phosphatidylglycerophosphatase B HVY75_RS03335 ENOG4107QM5 aconitate hydratase HVY75_RS03350 ENOG4107R11 Transcriptional regulator HVY75_RS03355 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY75_RS03360 ENOG4105RKX Protein of unknown function (DUF2498) HVY75_RS03365 ENOG4105ERU peptidase HVY75_RS03370 ENOG4105UBK short-chain dehydrogenase reductase HVY75_RS03375 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVY75_RS03380 ENOG4105FE9 pseudouridine synthase HVY75_RS03385 ENOG4105EG3 transmembrane signal peptide protein HVY75_RS03390 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVY75_RS03395 ENOG4105DB7 PHP domain protein HVY75_RS03405 ENOG4105CRQ synthase (Component I) HVY75_RS03410 ENOG4108EFP Anthranilate synthase component II HVY75_RS03415 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVY75_RS03430 ENOG4105EIF outer membrane protein W HVY75_RS03435 ENOG4105PI0 Ferredoxin HVY75_RS03450 ENOG4105NAU thioesterase Superfamily protein HVY75_RS03455 ENOG410822N TonB family HVY75_RS03460 ENOG4105K9H YciI-like protein HVY75_RS03470 ENOG4105D7V transposase HVY75_RS03485 ENOG4105EYW Ion transport protein HVY75_RS03490 ENOG4108JQ7 (ABC) transporter HVY75_RS03495 ENOG4105C3U ABC transporter HVY75_RS03500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY75_RS03505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY75_RS03510 ENOG4107QSI ABC, transporter HVY75_RS03515 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVY75_RS03520 ENOG4105C0A alcohol dehydrogenase HVY75_RS03525 ENOG4105VNT transposase (IS4 family) protein HVY75_RS03530 ENOG4107104 thymidine kinase HVY75_RS03540 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY75_RS03545 ENOG4105I93 response regulator HVY75_RS03550 ENOG4105D78 K07001 NTE family protein HVY75_RS03560 ENOG4105CIY formyltetrahydrofolate deformylase HVY75_RS03605 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY75_RS03610 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVY75_RS03615 ENOG41076YT nitrate reductase, gamma subunit HVY75_RS03620 ENOG4105R3A Nitrate reductase HVY75_RS03625 ENOG4108IUE nitrate reductase beta subunit HVY75_RS03630 ENOG4105CRU nitrate reductase, alpha subunit HVY75_RS03635 ENOG4105DQQ Major facilitator superfamily MFS_1 HVY75_RS03640 ENOG4105BZU Histidine kinase HVY75_RS03645 ENOG4105WH1 Two component transcriptional regulator luxr family HVY75_RS03650 ENOG4105ID0 Putative invasin HVY75_RS03655 ENOG41090EX DsrE family HVY75_RS03660 ENOG4108NH8 Cation transport protein HVY75_RS03665 ENOG4105WS7 Cation transport regulator HVY75_RS03670 ENOG4105EWV Sodium calcium exchanger membrane region HVY75_RS03685 ENOG41063JG Transcriptional regulator HVY75_RS03690 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVY75_RS03715 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVY75_RS03720 ENOG4105CHH sulfate transporter HVY75_RS03725 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVY75_RS03735 ENOG4105C3G gtp-binding protein HVY75_RS03790 ENOG4105E53 ec 3.2.1.28 HVY75_RS03800 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVY75_RS03810 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVY75_RS03820 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY75_RS03830 ENOG4105ED1 spovr family HVY75_RS03845 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVY75_RS03850 ENOG4105TNG K13735 adhesin invasin HVY75_RS03860 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVY75_RS03875 ENOG4107QMS site-determining protein HVY75_RS03885 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY75_RS03890 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY75_RS03895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY75_RS03905 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVY75_RS03925 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVY75_RS03930 ENOG4105CDY transcriptional regulatory protein HVY75_RS03940 ENOG4105TNG K13735 adhesin invasin HVY75_RS03955 ENOG4105JAB phenazine biosynthesis protein, phzf family HVY75_RS03960 ENOG4108I1J Integrase HVY75_RS03965 ENOG4108HMX isocitrate dehydrogenase (NADP) HVY75_RS03970 ENOG4108R99 pseudouridine synthase HVY75_RS03990 ENOG4107QTF adenylosuccinate lyase HVY75_RS03995 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY75_RS04000 ENOG4105IFJ Histidine kinase HVY75_RS04005 ENOG4105EZE Cupin 4 family protein HVY75_RS04010 ENOG4105CV8 reductase HVY75_RS04015 ENOG4105GNX MltA-interacting MipA family protein HVY75_RS04020 ENOG4105CYN Serine protein kinase HVY75_RS04030 ENOG4106KTS Inner membrane protein yeaI HVY75_RS04035 ENOG4108KHP Diguanylate cyclase HVY75_RS04040 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVY75_RS04055 ENOG4105DJ2 Major Facilitator Superfamily HVY75_RS04060 ENOG4105K78 MarR family Transcriptional regulator HVY75_RS04065 ENOG4105UCG Domain of unknown function (DUF333) HVY75_RS04070 ENOG410620I Diguanylate cyclase HVY75_RS04075 ENOG4106G4W HVY75_RS04085 ENOG4105Y3U Transglycosylase-associated protein HVY75_RS04095 ENOG4107MBR 17 kDa surface antigen HVY75_RS04100 ENOG4105CEP NADH dehydrogenase HVY75_RS04115 ENOG4108RUM thiamine kinase HVY75_RS04120 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVY75_RS04125 ENOG41090DQ Lipoprotein HVY75_RS04130 ENOG4105K59 histidine triad (HIT) protein HVY75_RS04135 ENOG4105CI1 PTS System HVY75_RS04140 ENOG4105F8V Hydrolase, tatD family HVY75_RS04145 ENOG4107QRG dna polymerase iii HVY75_RS04155 ENOG4105HHA aminodeoxychorismate lyase HVY75_RS04160 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVY75_RS04165 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY75_RS04170 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVY75_RS04175 ENOG4105CHR reductase HVY75_RS04180 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVY75_RS04185 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVY75_RS04195 ENOG4105VGS 50s ribosomal protein l32 HVY75_RS04200 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVY75_RS04205 ENOG4108UHJ MAF-like protein HVY75_RS04210 ENOG4105EI2 Pseudouridine synthase HVY75_RS04215 ENOG4107QQB Ribonuclease E HVY75_RS04220 ENOG4105DTJ flagellar hook-associated protein HVY75_RS04225 ENOG4105E1Q flagellar hook-associated protein HVY75_RS04230 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVY75_RS04245 ENOG4105CGA flagellar basal-body rod protein FlgG HVY75_RS04250 ENOG4108KPB Flagellar basal-body rod protein FlgF HVY75_RS04255 ENOG4105BZE flagellar hook protein, FlgE HVY75_RS04260 ENOG4105W00 Flagellar hook capping protein HVY75_RS04265 ENOG4108ZC9 flagellar basal-body rod protein flgc HVY75_RS04270 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVY75_RS04275 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVY75_RS04280 ENOG4105M9M anti-sigma28 factor FlgM HVY75_RS04285 ENOG4105QVD Flagella synthesis protein FlgN HVY75_RS04290 ENOG4105CJR Integral membrane protein (MviN HVY75_RS04295 ENOG4105EP9 oxidoreductase HVY75_RS04305 ENOG4105D9U N-acetyltransferase HVY75_RS04315 ENOG4105F3T (LipO)protein HVY75_RS04325 ENOG4105MEA DNA damage-inducible protein i HVY75_RS04330 ENOG4105PVA Biofilm formation regulatory protein BssS HVY75_RS04340 ENOG4105DS1 cytochrome b561 HVY75_RS04345 ENOG4108YYC ycei family HVY75_RS04355 ENOG4105D1S lipid A biosynthesis HVY75_RS04365 ENOG4108W47 Acidic protein msyB HVY75_RS04370 ENOG4105NAC (LipO)protein HVY75_RS04375 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVY75_RS04385 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HVY75_RS04390 ENOG4107RZC phospholipase d HVY75_RS04405 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HVY75_RS04410 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVY75_RS04415 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVY75_RS04420 ENOG41086KC Transcriptional regulator HVY75_RS04425 ENOG4108XDW curli assembly protein CsgE HVY75_RS04430 ENOG4108WYR Curli production assembly transport component, CsgF HVY75_RS04435 ENOG4105P8Q Curli production assembly transport component CsgG HVY75_RS04440 ENOG4108UQ5 membrane protein YcdZ HVY75_RS04445 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVY75_RS04465 ENOG4105CRK lysyL-tRNA synthetase HVY75_RS04470 ENOG4105DUX Transporter HVY75_RS04475 ENOG4105CXN decarboxylase HVY75_RS04480 ENOG4105D5Q Arginine ornithine antiporter HVY75_RS04485 ENOG4108M3R transcriptional activator CadC HVY75_RS04490 ENOG4105BZU Histidine kinase HVY75_RS04495 ENOG4108TUY outer membrane protein PgaA HVY75_RS04500 ENOG4107BJW polysaccharide deacetylase HVY75_RS04505 ENOG4105CND Glycosyl transferase, family 2 HVY75_RS04515 ENOG4105D5M phosphate starvation-inducible protein HVY75_RS04520 ENOG4105DBE peroxidase HVY75_RS04525 ENOG410650H (LipO)protein HVY75_RS04535 ENOG4105CK7 Sodium proline symporter HVY75_RS04545 ENOG4105C26 Dehydrogenase HVY75_RS04550 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVY75_RS04555 ENOG4108MJ5 VirK protein HVY75_RS04560 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HVY75_RS04565 ENOG4107BJW polysaccharide deacetylase HVY75_RS04570 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVY75_RS04575 ENOG4105KT5 UmuD protein HVY75_RS04585 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVY75_RS04590 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY75_RS04595 ENOG41090PJ Flagellar assembly protein HVY75_RS04600 ENOG4108JIR Flagellum-specific ATP synthase HVY75_RS04605 ENOG4105GSA Flagellar export protein flij HVY75_RS04610 ENOG4105WF4 Flagellar hook-length control protein HVY75_RS04615 ENOG4107ZI8 flagellar basal body-associated protein flil HVY75_RS04620 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY75_RS04625 ENOG4105DD5 Flagellar motor switch protein HVY75_RS04630 ENOG4105K0P flagellar biosynthesis protein HVY75_RS04635 ENOG4105CN7 Flagellar biosynthetic protein FliP HVY75_RS04640 ENOG4105VS8 Flagellar biosynthetic protein fliq HVY75_RS04645 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVY75_RS04650 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVY75_RS04660 ENOG4105YX3 cellular response to acidity HVY75_RS04675 ENOG4105VNZ cytoplasmic protein HVY75_RS04680 ENOG4105CKW Inner membrane protein yedI HVY75_RS04685 ENOG4105FDR Membrane HVY75_RS04690 ENOG41090BB DNA mismatch endonuclease (vsr) HVY75_RS04695 ENOG4105EST Metal Dependent Phosphohydrolase HVY75_RS04700 ENOG4105Y0K Inner membrane protein YedR HVY75_RS04705 ENOG4105ZIT Porin Gram-negative type HVY75_RS04715 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY75_RS04740 ENOG4107R11 Transcriptional regulator HVY75_RS04790 ENOG4105GMB type VI secretion system effector, hcp1 family HVY75_RS04815 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY75_RS04865 ENOG4108WC9 type VI secretion system effector, hcp1 family HVY75_RS04870 ENOG4105CS6 Rhs element vgr protein HVY75_RS04910 ENOG4105FYV Amp nucleosidase HVY75_RS04915 ENOG4105CSH Transporter HVY75_RS04925 ENOG4105UQX Mate efflux family protein HVY75_RS04950 ENOG4105KNY Microcompartments protein HVY75_RS04955 ENOG4105KNY Microcompartments protein HVY75_RS04960 ENOG4105KNY Microcompartments protein HVY75_RS04965 ENOG4105C0A alcohol dehydrogenase HVY75_RS04975 ENOG4105C0A alcohol dehydrogenase HVY75_RS04980 ENOG4105C6N Formate acetyltransferase HVY75_RS04985 ENOG4105F1A Pyruvate formate-lyase HVY75_RS04990 ENOG4105KNY Microcompartments protein HVY75_RS04995 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVY75_RS05015 ENOG4108PXI ErfK YbiS YcfS YnhG HVY75_RS05020 ENOG4108P62 biosynthesis protein (CbiG) HVY75_RS05030 ENOG4107XVH Transcriptional regulator HVY75_RS05035 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY75_RS05040 ENOG4105KNY Microcompartments protein HVY75_RS05045 ENOG4105EHR propanediol utilization protein pduB HVY75_RS05050 ENOG4105DMB glycerol dehydratase HVY75_RS05055 ENOG4105YCI dehydratase medium subunit HVY75_RS05060 ENOG4108ZFT Dehydratase small subunit HVY75_RS05065 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVY75_RS05075 ENOG4105KNY Microcompartments protein HVY75_RS05095 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVY75_RS05105 ENOG4108EKI Dehydrogenase HVY75_RS05115 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVY75_RS05125 ENOG4105M3W utilization protein HVY75_RS05130 ENOG4105KTW ethanolamine utilization protein HVY75_RS05145 ENOG4105DR8 Membrane HVY75_RS05155 ENOG4105CJB Exodeoxyribonuclease I HVY75_RS05165 ENOG4105CUC YeeE YedE family protein HVY75_RS05170 ENOG4105CUB amino acid HVY75_RS05180 ENOG4105EQ1 Transcriptional regulator HVY75_RS05185 ENOG4107SRH Nad-dependent epimerase dehydratase HVY75_RS05190 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVY75_RS05195 ENOG4105VTW prevent-host-death family HVY75_RS05210 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVY75_RS05220 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVY75_RS05225 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVY75_RS05255 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVY75_RS05285 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVY75_RS05290 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY75_RS05295 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVY75_RS05300 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY75_RS05305 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY75_RS05310 ENOG4105DMT epimerase dehydratase HVY75_RS05315 ENOG4105G1A colanic acid biosynthesis protein HVY75_RS05320 ENOG4107T8Q Glycosyl transferase (Group 1 HVY75_RS05325 ENOG4105C74 pyruvyl transferase HVY75_RS05330 ENOG4105PSV Polysaccharide Biosynthesis Protein HVY75_RS05335 ENOG4105D3Q Sugar transferase HVY75_RS05340 ENOG4107QKV phosphomannomutase HVY75_RS05345 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVY75_RS05350 ENOG4106CD9 glycosyl transferase group 1 HVY75_RS05355 ENOG4105FGF GDP-mannose mannosyl hydrolase HVY75_RS05360 ENOG4105C30 Nad-dependent epimerase dehydratase HVY75_RS05365 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVY75_RS05370 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVY75_RS05375 ENOG4105ECJ Glycosyl Transferase HVY75_RS05380 ENOG4108NYJ Colanic acid HVY75_RS05385 ENOG4107RXY Glycosyl transferase HVY75_RS05390 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVY75_RS05395 ENOG41090RK glycosyl transferase HVY75_RS05400 ENOG4105D75 Capsular exopolysaccharide family HVY75_RS05405 ENOG4105KJF protein tyrosine phosphatase HVY75_RS05410 ENOG4105DAY polysaccharide export protein HVY75_RS05415 ENOG4105EE5 Membrane protein terC HVY75_RS05430 ENOG4108GAE asmA family HVY75_RS05445 ENOG4105BZU Histidine kinase HVY75_RS05450 ENOG4105D03 DNA-3-methyladenine glycosylase II HVY75_RS05455 ENOG4105R8A Heat shock protein HVY75_RS05460 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVY75_RS05465 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HVY75_RS05470 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVY75_RS05475 ENOG4108M24 von Willebrand factor, type A HVY75_RS05515 ENOG4105EB3 Histidine kinase HVY75_RS05520 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY75_RS05525 ENOG4105KWI UPF0339 protein HVY75_RS05530 ENOG4105CFP Peptidase U32 HVY75_RS05540 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVY75_RS05545 ENOG4105IE8 Alpha-ketoglutarate permease HVY75_RS05550 ENOG4105CMG Carbohydrate kinase HVY75_RS05555 ENOG4105DEI Mannitol dehydrogenase HVY75_RS05575 ENOG4105EF1 ribulokinase HVY75_RS05580 ENOG4105IE8 Alpha-ketoglutarate permease HVY75_RS05585 ENOG4105EIE fructose-bisphosphate aldolase HVY75_RS05590 ENOG4105EAA nucleoside HVY75_RS05595 ENOG4108KD5 ADP-ribosylation crystallin J1 HVY75_RS05600 ENOG4108TFM Kinase, PfkB family HVY75_RS05605 ENOG4105FDP GntR family transcriptional regulator HVY75_RS05610 ENOG4108UQ1 hydrolase, family 25 HVY75_RS05615 ENOG4105DWF phosphomethylpyrimidine kinase HVY75_RS05625 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVY75_RS05630 ENOG410662B Type-1 fimbrial protein HVY75_RS05635 ENOG4105CW0 outer membrane usher protein HVY75_RS05640 ENOG4108MQF Chaperone HVY75_RS05650 ENOG41067AK Protein of unknown function (DUF2574) HVY75_RS05655 ENOG4105D1F ATP-binding protein HVY75_RS05665 ENOG4108KDT Molybdate metabolism regulator HVY75_RS05670 ENOG4108KDT Molybdate metabolism regulator HVY75_RS05675 ENOG4108KDT Molybdate metabolism regulator HVY75_RS05685 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVY75_RS05690 ENOG4105RD5 HVY75_RS05695 ENOG4105DEG Vwa containing coxe family protein HVY75_RS05700 ENOG410903U zinc ion binding HVY75_RS05705 ENOG4108YCW (LipO)protein HVY75_RS05710 ENOG4108W15 Protein of unknown function (DUF1456) HVY75_RS05715 ENOG4108NEV two component transcriptional regulator, LytTR family HVY75_RS05720 ENOG4108HRK Histidine kinase HVY75_RS05725 ENOG4108XDN Transcriptional regulator HVY75_RS05735 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVY75_RS05740 ENOG4108IJ8 ABC transporter HVY75_RS05745 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVY75_RS05750 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVY75_RS05755 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVY75_RS05760 ENOG4105CXG d-lactate dehydrogenase HVY75_RS05765 ENOG41061WM D-Alanyl-D-Alanine HVY75_RS05770 ENOG41069YE inner membrane protein yohC HVY75_RS05775 ENOG4105KHU inner membrane protein YohD HVY75_RS05780 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVY75_RS05790 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVY75_RS05800 ENOG41067MG lrgb family HVY75_RS05810 ENOG4107GZ4 SanA protein HVY75_RS05815 ENOG4105Y9N Membrane HVY75_RS05820 ENOG4105BZ8 glutamate synthase HVY75_RS05825 ENOG4107SJI Dehydrogenase HVY75_RS05830 ENOG4108HWV )-transporter HVY75_RS05835 ENOG4105C2J ABC transporter HVY75_RS05840 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVY75_RS05845 ENOG41060NJ transcriptional regulator HVY75_RS05850 ENOG4105DHF Membrane HVY75_RS05865 ENOG4105D05 Receptor HVY75_RS05870 ENOG4108IQI permease HVY75_RS05875 ENOG4105DUM transcriptional regulator, lysR family HVY75_RS05880 ENOG4105HMI Membrane HVY75_RS05890 ENOG4105DD7 kinase (PfkB family HVY75_RS05895 ENOG4105D9N nucleoside HVY75_RS05905 ENOG4108Y4K DNA-binding transcriptional activator HVY75_RS05910 ENOG4105D9N nucleoside HVY75_RS05915 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVY75_RS05920 ENOG4105DD7 kinase (PfkB family HVY75_RS05925 ENOG4105DM4 PTS System HVY75_RS05930 ENOG4105DE4 1-phosphofructokinase HVY75_RS05935 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVY75_RS05940 ENOG4105S8Q sugar efflux transporter HVY75_RS05945 ENOG4105KRS Proteinase inhibitor HVY75_RS05955 ENOG4105DEI Mannitol dehydrogenase HVY75_RS05960 ENOG4105CKI cobalamin synthesis protein HVY75_RS05965 ENOG41076MN Phosphoesterase, PA-phosphatase related HVY75_RS05970 ENOG4107TT5 NLP P60 protein HVY75_RS05975 ENOG4105CXC rtn protein HVY75_RS05980 ENOG4105E43 Extracellular solute-binding protein, family 5 HVY75_RS05985 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVY75_RS05990 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVY75_RS05995 ENOG4108JQ5 ABC transporter HVY75_RS06000 ENOG4105HG6 HVY75_RS06005 ENOG4105C2C drug resistance transporter, Bcr CflA HVY75_RS06010 ENOG4105I08 Pseudouridine synthase HVY75_RS06015 ENOG4105CFI type iii restriction protein res subunit HVY75_RS06040 ENOG4105E68 Sulfatase HVY75_RS06050 ENOG4105DFP Integrase HVY75_RS06105 ENOG410658X HVY75_RS06110 ENOG4105WH1 Two component transcriptional regulator luxr family HVY75_RS06115 ENOG4105KWW Biogenesis protein HVY75_RS06120 ENOG4107QX9 Thiol disulfide interChange protein HVY75_RS06125 ENOG4105DA4 cytochrome c-type biogenesis protein HVY75_RS06135 ENOG4105X3C heme exporter protein HVY75_RS06140 ENOG41060IM Heme exporter protein HVY75_RS06145 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVY75_RS06155 ENOG4105CUW cytochrome C-TYPE protein HVY75_RS06160 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVY75_RS06165 ENOG4105GXZ Ferredoxin-type protein NapH HVY75_RS06170 ENOG4108BGM Quinol dehydrogenase periplasmic component HVY75_RS06180 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVY75_RS06185 ENOG4108ZNS ferredoxin-type protein NapF HVY75_RS06195 ENOG4105D8X mechanosensitive ion channel HVY75_RS06205 ENOG4105ZY9 UPF0379 protein ybiM HVY75_RS06210 ENOG4108IU3 tonb-dependent siderophore receptor HVY75_RS06220 ENOG4105KSC Transcriptional regulator, TraR DksA family HVY75_RS06225 ENOG4105VR4 UPF0379 protein ybiJ HVY75_RS06230 ENOG4105DG4 malate L-lactate dehydrogenase HVY75_RS06235 ENOG4108MTB glycosyl transferase family HVY75_RS06240 ENOG4105DVT helicase HVY75_RS06245 ENOG4108UV1 cellular component movement HVY75_RS06250 ENOG4105C1J atp-dependent rna helicase HVY75_RS06255 ENOG4107MVR Transcriptional regulator HVY75_RS06265 ENOG4105CJ1 ABC, transporter HVY75_RS06270 ENOG4107QWP ABC-2 type transporter HVY75_RS06275 ENOG4107QWP ABC-2 type transporter HVY75_RS06280 ENOG4105I9U inner membrane protein ybhQ HVY75_RS06285 ENOG4105X23 Endonuclease Exonuclease phosphatase HVY75_RS06290 ENOG4105DZQ phospholipase D Transphosphatidylase HVY75_RS06295 ENOG4107UXM Membrane HVY75_RS06300 ENOG410733J conserved inner membrane protein HVY75_RS06305 ENOG4105DIJ Phosphoethanolamine transferase HVY75_RS06310 ENOG4105HFZ Membrane HVY75_RS06315 ENOG4108ZAF Molybdopterin HVY75_RS06320 ENOG4105M00 molybdopterin converting factor, subunit 1 HVY75_RS06330 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY75_RS06340 ENOG4105CHW UPF0052 protein HVY75_RS06350 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY75_RS06355 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVY75_RS06370 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVY75_RS06375 ENOG4108V1U phospholipid-binding protein HVY75_RS06380 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVY75_RS06385 ENOG4105CKK Glycosyl transferase, family 2 HVY75_RS06470 ENOG4108N0N Phage Terminase Large Subunit HVY75_RS06490 ENOG4106050 phage regulatory protein, rha family HVY75_RS06500 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVY75_RS06505 ENOG4105KUS lysozyme HVY75_RS06520 ENOG4108R1E Serine threonine protein phosphatase 1 HVY75_RS06550 ENOG4105NY2 NinB protein HVY75_RS06570 ENOG4105CDU Replicative dna helicase HVY75_RS06635 ENOG4108PNI recT protein HVY75_RS06685 ENOG4108I1J Integrase HVY75_RS06690 ENOG4105NBR Pectinesterase HVY75_RS06700 ENOG4108K4B hydrolase HVY75_RS06710 ENOG4105E0C molybdate abc transporter HVY75_RS06715 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVY75_RS06725 ENOG4105F4R Transcriptional regulator mode HVY75_RS06730 ENOG4105DKW ABC transporter HVY75_RS06735 ENOG4105CMR udp-glucose 4-epimerase HVY75_RS06740 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVY75_RS06750 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVY75_RS06760 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY75_RS06765 ENOG4105JND homeobox protein HVY75_RS06770 ENOG4105PGM cation diffusion facilitator family transporter HVY75_RS06775 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY75_RS06825 ENOG4105UFD tol-pal system protein YbgF HVY75_RS06830 ENOG4105KCK Peptidoglycan-associated lipoprotein HVY75_RS06840 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVY75_RS06850 ENOG4105E02 MotA TolQ exbB proton channel HVY75_RS06855 ENOG4107YD3 Thioesterase HVY75_RS06860 ENOG4105KJB cyd operon protein YbgE HVY75_RS06870 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY75_RS06875 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY75_RS06880 ENOG4105C8I hydrolase, family 38 HVY75_RS06885 ENOG4105DM4 PTS System HVY75_RS06890 ENOG4105FDP GntR family transcriptional regulator HVY75_RS06895 ENOG4107WFU Glutamate mutase subunit sigma HVY75_RS06905 ENOG4105DJI Methylaspartate mutase, E subunit HVY75_RS06930 ENOG4107GFK fumarate HVY75_RS06935 ENOG4105ETT transcriptional Regulator, LysR family HVY75_RS06940 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVY75_RS06950 ENOG4105C7S Dehydrogenase HVY75_RS06955 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVY75_RS06960 ENOG4105E33 succinate dehydrogenase HVY75_RS06965 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY75_RS06970 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVY75_RS06975 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVY75_RS06980 ENOG4105BZN citrate synthase HVY75_RS06995 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY75_RS07005 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY75_RS07010 ENOG4105CTX dehydratase HVY75_RS07020 ENOG4105CHR reductase HVY75_RS07025 ENOG4105CPQ Dehydrogenase HVY75_RS07030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVY75_RS07035 ENOG41073TP transcriptional regulator HVY75_RS07040 ENOG4106UBK fimbrial-like adhesin protein HVY75_RS07045 ENOG4106PG1 outer membrane usher protein HVY75_RS07050 ENOG4108TTM chaperone HVY75_RS07055 ENOG4108MY7 Fimbrial HVY75_RS07060 ENOG4108KK1 membrane protein AbrB duplication HVY75_RS07085 ENOG4107R7A Allophanate hydrolase subunit 2 HVY75_RS07090 ENOG4105P4J Allophanate hydrolase, subunit 1 HVY75_RS07095 ENOG4107QNR UPF0135 protein HVY75_RS07100 ENOG4105DUX Transporter HVY75_RS07105 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVY75_RS07110 ENOG4107SEY Conserved Protein HVY75_RS07140 ENOG4105XIQ Protein of unknown function (DUF2517) HVY75_RS07165 ENOG4105C08 Histidine kinase HVY75_RS07170 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVY75_RS07175 ENOG4105CXN decarboxylase HVY75_RS07180 ENOG4105D5Q Arginine ornithine antiporter HVY75_RS07185 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVY75_RS07190 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVY75_RS07195 ENOG4105EV9 Alpha Beta Hydrolase HVY75_RS07200 ENOG4105NNH LexA regulated protein HVY75_RS07205 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVY75_RS07215 ENOG41090R7 Ferric uptake HVY75_RS07220 ENOG4105GX6 (LipO)protein HVY75_RS07235 ENOG4105CI1 PTS System HVY75_RS07245 ENOG4105CE4 GlcNAc 6-P deacetylase HVY75_RS07250 ENOG4105E2R ROK family HVY75_RS07255 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVY75_RS07260 ENOG4105CAQ asparagine synthetase HVY75_RS07310 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY75_RS07320 ENOG4105C9A Phoh family HVY75_RS07330 ENOG4108JU5 Magnesium and cobalt efflux protein HVY75_RS07335 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVY75_RS07340 ENOG4107U91 Rhomboid family HVY75_RS07345 ENOG4107RP9 extracellular solute-binding protein, family 3 HVY75_RS07350 ENOG4105EAD ABC transporter HVY75_RS07355 ENOG4105DRP amino acid AbC transporter HVY75_RS07360 ENOG4105CDA abc transporter atp-binding protein HVY75_RS07370 ENOG4105F7F Chaperone HVY75_RS07375 ENOG4105QFC Hsc56 co-chaperone of HscC HVY75_RS07380 ENOG41069CF Protein of unknown function (DUF1266) HVY75_RS07385 ENOG4107JFD Sel1 repeat HVY75_RS07390 ENOG4105QFC Hsc56 co-chaperone of HscC HVY75_RS07395 ENOG41069CF Protein of unknown function (DUF1266) HVY75_RS07400 ENOG4105EUU Sel1 domain protein repeat-containing protein HVY75_RS07405 ENOG4107PAI alpha helical protein HVY75_RS07420 ENOG4105DJF DNA polymerase III, delta' subunit HVY75_RS07430 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVY75_RS07440 ENOG4105CJN penicillin-binding protein HVY75_RS07445 ENOG4105CNI cell division protein FtsW HVY75_RS07450 ENOG4105K6T rare lipoprotein A HVY75_RS07455 ENOG4105DZ1 carboxypeptidase HVY75_RS07465 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HVY75_RS07495 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVY75_RS07500 ENOG4105CEE C4-dicarboxylate transporter HVY75_RS07505 ENOG4105KTS ribonuclease HVY75_RS07510 ENOG4105NXH GreA GreB family elongation factor HVY75_RS07515 ENOG4108U51 Universal stress protein HVY75_RS07520 ENOG4108JU3 Alkyl hydroperoxide reductase HVY75_RS07525 ENOG4105D3R alkyl hydroperoxide reductase HVY75_RS07530 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVY75_RS07535 ENOG4105DQS Transcriptional regulator HVY75_RS07540 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVY75_RS07545 ENOG4105GTN ParB Domain Protein Nuclease HVY75_RS07550 ENOG4105CHM Aminotransferase HVY75_RS07555 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVY75_RS07560 ENOG4105VCD cytoplasmic protein HVY75_RS07565 ENOG4105D22 carbon starvation protein HVY75_RS07570 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVY75_RS07575 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVY75_RS07580 ENOG4105WQI isochorismatase HVY75_RS07585 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVY75_RS07590 ENOG4105E4F Isochorismate synthase HVY75_RS07595 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVY75_RS07605 ENOG4105DQ5 transport system permease protein HVY75_RS07610 ENOG4105TVJ transport system, permease HVY75_RS07615 ENOG4105E0A ABC, transporter HVY75_RS07620 ENOG4108QY5 Ferric enterobactin transport protein HVY75_RS07625 ENOG4105C0W non-ribosomal peptide synthetase HVY75_RS07630 ENOG41085A6 mbth domain-containing protein HVY75_RS07635 ENOG4105E93 esterase HVY75_RS07640 ENOG4107RNH Outer membrane receptor FepA HVY75_RS07645 ENOG4108TSE Transferase HVY75_RS07665 ENOG4105WQ6 Membrane HVY75_RS07670 ENOG4105MSB protein, conserved in bacteria HVY75_RS07675 ENOG4108RCM Nitroreductase HVY75_RS07680 ENOG4105CUY Mechanosensitive ion channel HVY75_RS07685 ENOG4105C85 amino acid HVY75_RS07690 ENOG4108IJF Heavy metal efflux pump, CzcA HVY75_RS07695 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVY75_RS07700 ENOG410624V efflux system protein HVY75_RS07705 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVY75_RS07710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY75_RS07715 ENOG4105GR3 Histidine kinase HVY75_RS07750 ENOG4107QMP dna polymerase iii subunits gamma and tau HVY75_RS07760 ENOG4105WD1 Membrane HVY75_RS07765 ENOG4108URS primosomal replication protein n'' HVY75_RS07770 ENOG4106428 Protein of unknown function (DUF2496) HVY75_RS07775 ENOG4105EGS Mechanosensitive ion channel HVY75_RS07780 ENOG4107XI7 Tetr family transcriptional regulator HVY75_RS07785 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY75_RS07790 ENOG4105BZS acriflavin resistance protein HVY75_RS07795 ENOG4108UKR Biofilm formation regulator YbaJ HVY75_RS07805 ENOG4105GSJ Inner membrane protein ylaC HVY75_RS07810 ENOG41066DG (EAL) domain protein HVY75_RS07815 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVY75_RS07825 ENOG41080UX Methyltransferase HVY75_RS07830 ENOG4108MNP Glycoprotein polysaccharide metabolism HVY75_RS07835 ENOG4105C29 acyl-CoA thioesterase HVY75_RS07840 ENOG4105BZU Histidine kinase HVY75_RS07845 ENOG4108YZA Nitrogen regulatory protein pii HVY75_RS07850 ENOG4105BZ1 (ABC) transporter HVY75_RS07855 ENOG4105BZ1 (ABC) transporter HVY75_RS07860 ENOG4108XM1 transcriptional regulator AsnC family HVY75_RS07870 ENOG4108NFA extracellular solute-binding protein HVY75_RS07880 ENOG4108TGP Thioesterase superfamily protein HVY75_RS07885 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVY75_RS07890 ENOG4105EIN peptidylprolyl cis-trans isomerase HVY75_RS07895 ENOG4105K70 DNA-binding protein HVY75_RS07900 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVY75_RS07920 ENOG4105M85 Bola protein HVY75_RS07925 ENOG4105IEY (LipO)protein HVY75_RS07930 ENOG4105EYM Major Facilitator superfamily HVY75_RS07935 ENOG4105E2S oxidase) subunit II HVY75_RS07940 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVY75_RS07945 ENOG4105CCU oxidase (Subunit III) HVY75_RS07950 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVY75_RS07970 ENOG4107HP6 Transcriptional regulator HVY75_RS07975 ENOG4107V59 shikimate HVY75_RS07980 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVY75_RS07990 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVY75_RS08000 ENOG4105D2S major facilitator superfamily HVY75_RS08005 ENOG4107RDB Major Facilitator HVY75_RS08015 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVY75_RS08020 ENOG4107S0N DJ-1 family HVY75_RS08035 ENOG4105CTB Polyprenyl synthetase HVY75_RS08040 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVY75_RS08045 ENOG4105CPC Aldo Keto reductase HVY75_RS08050 ENOG4108ZAI phosphatidylglycerophosphatase a HVY75_RS08055 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVY75_RS08065 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVY75_RS08070 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVY75_RS08080 ENOG4108KIC (LipO)protein HVY75_RS08085 ENOG4105DRB nucleoside-specific channel-forming protein HVY75_RS08090 ENOG4105N1F Hnh endonuclease HVY75_RS08095 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY75_RS08100 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY75_RS08105 ENOG4105VIE preprotein translocase, subunit YajC HVY75_RS08125 ENOG4107R28 alpha amylase, catalytic region HVY75_RS08130 ENOG4105C85 amino acid HVY75_RS08135 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVY75_RS08140 ENOG4105BZU Histidine kinase HVY75_RS08150 ENOG4107RH8 nuclease SbcCD subunit D HVY75_RS08155 ENOG4105EYH Exonuclease HVY75_RS08160 ENOG4105DKQ ROK family HVY75_RS08175 ENOG4105HBA AroM protein HVY75_RS08180 ENOG4105SS3 HVY75_RS08195 ENOG4105II7 pyrroline-5-carboxylate reductase HVY75_RS08200 ENOG4105BZU Histidine kinase HVY75_RS08205 ENOG4105VIF phosphate starvation-inducible protein HVY75_RS08220 ENOG4105CPF Cell wall formation (By similarity) HVY75_RS08225 ENOG4105UNH Membrane HVY75_RS08230 ENOG4105FR5 inner membrane protein YaiY HVY75_RS08235 ENOG4107QS8 (LipO)protein HVY75_RS08240 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVY75_RS08245 ENOG4107R6D beta-lactam binding protein AmpH HVY75_RS08250 ENOG4108PNB DNA-binding transcriptional regulator HVY75_RS08255 ENOG4108NSE outer membrane autotransporter barrel HVY75_RS08260 ENOG4105D52 delta-aminolevulinic acid dehydratase HVY75_RS08265 ENOG4105E2B Taurine dioxygenase HVY75_RS08270 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVY75_RS08275 ENOG4108IY8 ABC, transporter HVY75_RS08280 ENOG4106FTQ Taurine ABC transporter, periplasmic HVY75_RS08285 ENOG4107W19 lmbE family HVY75_RS08295 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY75_RS08300 ENOG4105DXD 2-methylcitrate dehydratase HVY75_RS08305 ENOG4105BZN citrate synthase HVY75_RS08310 ENOG4105CR4 methylisocitrate lyase HVY75_RS08315 ENOG4108JU7 Transcriptional regulator HVY75_RS08320 ENOG4105TDT uncharacterized protein yahO HVY75_RS08325 ENOG4105E82 cytochrome subunit of dehydrogenase HVY75_RS08330 ENOG4105BZU Histidine kinase HVY75_RS08335 ENOG4105C6F GntR Family Transcriptional Regulator HVY75_RS08340 ENOG4105CPQ Dehydrogenase HVY75_RS08345 ENOG4108I5G Major Facilitator superfamily HVY75_RS08350 ENOG4105BZU Histidine kinase HVY75_RS08360 ENOG4105BZU Histidine kinase HVY75_RS08365 ENOG4108HF7 Gcn5-related n-acetyltransferase HVY75_RS08375 ENOG4107SET aldo keto reductase HVY75_RS08380 ENOG4105EQ2 LysR family Transcriptional regulator HVY75_RS08400 ENOG4105UZW Tail fiber assembly protein HVY75_RS08405 ENOG410685N tail fiber protein HVY75_RS08510 ENOG4105QYK bacteriophage lambda Bor protein homolog HVY75_RS08520 ENOG4105KUS lysozyme HVY75_RS08525 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY75_RS08530 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HVY75_RS08535 ENOG4107SEY Conserved Protein HVY75_RS08545 ENOG4105HRS Antitermination protein HVY75_RS08560 ENOG4105RWQ Protein of unknown function (DUF1364) HVY75_RS08565 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVY75_RS08570 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVY75_RS08590 ENOG4107TII Recombinase HVY75_RS08600 ENOG410814C multidrug resistance protein HVY75_RS08695 ENOG4108KU3 Integrase HVY75_RS08715 ENOG4105FCK Membrane HVY75_RS08735 ENOG4105CIN aminoacyl-histidine dipeptidase HVY75_RS08750 ENOG4108S2Y peptide Chain Release factor HVY75_RS08760 ENOG4108HYG acetyltransferase HVY75_RS08765 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HVY75_RS08785 ENOG4107QYX exodeoxyribonuclease v alpha HVY75_RS08790 ENOG4107QKA exodeoxyribonuclease V beta HVY75_RS08795 ENOG4107QXK peptidase HVY75_RS08800 ENOG4105DSY exodeoxyribonuclease V, gamma HVY75_RS08805 ENOG4105RVB Prepilin peptidase dependent protein c HVY75_RS08810 ENOG4105SEN Protein of unknown function (DUF2509) HVY75_RS08815 ENOG4105JCS prepilin peptidase dependent protein HVY75_RS08820 ENOG4105IPU prepilin peptidase dependent protein A HVY75_RS08835 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVY75_RS08850 ENOG4105EE5 Membrane protein terC HVY75_RS08855 ENOG4105SUV lipoprotein YgdR HVY75_RS08860 ENOG4105CPC Aldo Keto reductase HVY75_RS08885 ENOG41060NJ transcriptional regulator HVY75_RS08895 ENOG4105RQF LysR family Transcriptional regulator HVY75_RS08900 ENOG4105CHU acetyl-coa acetyltransferase HVY75_RS08905 ENOG4108MHD transport protein HVY75_RS08910 ENOG4105ISV protein with bipartite regulator domain HVY75_RS08915 ENOG4108TC1 Transcriptional regulator HVY75_RS08925 ENOG410802X bacteriophage n4 adsorption protein b HVY75_RS08930 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVY75_RS08935 ENOG4105QUW HVY75_RS08940 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVY75_RS08945 ENOG4105DZC cytosine deaminase HVY75_RS08965 ENOG4105TNG K13735 adhesin invasin HVY75_RS09075 ENOG4108K5P (LipO)protein HVY75_RS09080 ENOG4105MP9 class II Aldolase HVY75_RS09100 ENOG4105C5Q Transcriptional regulator HVY75_RS09105 ENOG4105H3G oxidoreductase HVY75_RS09110 ENOG4105KME endoribonuclease L-psp HVY75_RS09120 ENOG4105CWC Acetylornithine deacetylase HVY75_RS09125 ENOG4105CVK Glutamate decarboxylase HVY75_RS09130 ENOG4105CSV Glutaminase HVY75_RS09135 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVY75_RS09140 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVY75_RS09145 ENOG4105C7W Xanthine dehydrogenase HVY75_RS09150 ENOG4107XAN XdhC and CoxI family HVY75_RS09165 ENOG4105CRK lysyL-tRNA synthetase HVY75_RS09175 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVY75_RS09180 ENOG4105T95 Thiol disulfide interChange protein HVY75_RS09185 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY75_RS09190 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVY75_RS09195 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVY75_RS09200 ENOG4105Y75 tpr repeat protein HVY75_RS09210 ENOG4108UT2 hemolysin iii HVY75_RS09215 ENOG4105N5Z UPF0267 protein HVY75_RS09220 ENOG4105CS2 ec 3.2.1.21 HVY75_RS09250 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY75_RS09255 ENOG4105D0A hydroxylase HVY75_RS09260 ENOG4107RAQ aminopeptidase HVY75_RS09280 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVY75_RS09290 ENOG4108JQ1 Dehydrogenase HVY75_RS09305 ENOG4105MPN Membrane HVY75_RS09310 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVY75_RS09315 ENOG4105D64 Mechanosensitive ion channel HVY75_RS09320 ENOG4105D2N Aldolase HVY75_RS09335 ENOG4107Z1W Fructose transport system kinase HVY75_RS09340 ENOG4108R4K DNA-binding, transcriptional regulator HVY75_RS09345 ENOG4108Q8A Fructose-1,6-bisphosphatase HVY75_RS09350 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY75_RS09355 ENOG4105CTS PTS system mannitol-specific HVY75_RS09360 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVY75_RS09365 ENOG4105EPW hflc protein HVY75_RS09370 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY75_RS09375 ENOG4108K0D peptidase, M48 HVY75_RS09405 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVY75_RS09430 ENOG4107QNK )-transporter HVY75_RS09440 ENOG4105RWS endonuclease I HVY75_RS09445 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVY75_RS09450 ENOG4105D7Z glutathione synthase HVY75_RS09465 ENOG4105CZX twitching motility protein HVY75_RS09470 ENOG4105DFA alanine racemase domain protein HVY75_RS09475 ENOG4108VIA integral membrane protein HVY75_RS09485 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVY75_RS09490 ENOG4105CSA Coproporphyrinogen iii oxidase HVY75_RS09495 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY75_RS09500 ENOG41069H7 transport system small permease component HVY75_RS09505 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY75_RS09510 ENOG4106MH3 alpha helix chain HVY75_RS09515 ENOG4105HDK L-asparaginase HVY75_RS09520 ENOG4105K33 Periplasmic Protein HVY75_RS09525 ENOG41090ED Protein with unknown function (DUF469) HVY75_RS09535 ENOG4105CEN a g-specific adenine glycosylase HVY75_RS09550 ENOG4105EAA nucleoside HVY75_RS09555 ENOG4105CXN decarboxylase HVY75_RS09560 ENOG4108UQV Membrane HVY75_RS09585 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVY75_RS09595 ENOG4108XKW General secretion pathway protein C HVY75_RS09605 ENOG4107QHF type ii secretion system protein e HVY75_RS09610 ENOG4105D7Q type ii secretion system HVY75_RS09615 ENOG4108VAU general secretion pathway protein G HVY75_RS09625 ENOG4105X5Z General secretion pathway protein I HVY75_RS09645 ENOG4105U1E general secretion pathway protein M HVY75_RS09650 ENOG410600K aminopeptidase HVY75_RS09655 ENOG410600T transposase HVY75_RS09665 ENOG4106032 Glutathionylspermidine synthase HVY75_RS09675 ENOG4105CYM Glutathione S-transferase HVY75_RS09680 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVY75_RS09690 ENOG4108WGS hydrogenase 2-specific chaperone HVY75_RS09695 ENOG4108USZ hydrogenase HVY75_RS09700 ENOG4105DPX Hydrogenase, large subunit HVY75_RS09705 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVY75_RS09710 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY75_RS09715 ENOG4105E3S small subunit HVY75_RS09720 ENOG410900S Protein of unknown function (DUF2623) HVY75_RS09730 ENOG4105CPC Aldo Keto reductase HVY75_RS09740 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVY75_RS09745 ENOG4108ZZF transport protein (ExbD) HVY75_RS09750 ENOG4105CWK Biopolymer transport protein, ExbB HVY75_RS09755 ENOG4105C28 cystathionine HVY75_RS09760 ENOG4108K81 inner membrane protein YghB HVY75_RS09765 ENOG4105CF7 AraC family transcriptional regulator HVY75_RS09770 ENOG4108I6A alcohol dehydrogenase HVY75_RS09775 ENOG4105CV8 reductase HVY75_RS09780 ENOG4107QPK )-transporter HVY75_RS09790 ENOG4105CCT upf0313 protein HVY75_RS09795 ENOG4107YCY Transcriptional regulator HVY75_RS09800 ENOG4105DEI Mannitol dehydrogenase HVY75_RS09805 ENOG4105CPQ Dehydrogenase HVY75_RS09810 ENOG4105DG4 malate L-lactate dehydrogenase HVY75_RS09815 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY75_RS09825 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY75_RS09830 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVY75_RS09835 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVY75_RS09840 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY75_RS09845 ENOG4105H4F exported protein HVY75_RS09850 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY75_RS09855 ENOG4105DHQ Histidine kinase HVY75_RS09860 ENOG4105NF4 modulator of drug activity HVY75_RS09865 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVY75_RS09870 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY75_RS09875 ENOG4105IPS esterase HVY75_RS09880 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVY75_RS09885 ENOG4108SX3 cytoplasmic protein HVY75_RS09890 ENOG41087AY ADP-Ribose pyrophosphatase HVY75_RS09895 ENOG4105DFG type I secretion outer membrane protein HVY75_RS09905 ENOG4106032 Glutathionylspermidine synthase HVY75_RS09910 ENOG4108MR7 Arylsulfotransferase HVY75_RS09915 ENOG4108N92 Thiol disulfide Interchange Protein HVY75_RS09925 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVY75_RS09940 ENOG4105H8W Fimbrial protein HVY75_RS09950 ENOG4108TTM chaperone HVY75_RS09955 ENOG4108MY7 Fimbrial HVY75_RS09965 ENOG4105W0Z cytoplasmic protein HVY75_RS09975 ENOG4105PV3 Inner membrane protein yqiJ HVY75_RS09980 ENOG4107S78 Band 7 protein HVY75_RS10010 ENOG4105I7R Adenylate cyclase HVY75_RS10015 ENOG4106MWK domain protein HVY75_RS10030 ENOG4107ZVW dihydroneopterin aldolase HVY75_RS10040 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVY75_RS10050 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVY75_RS10055 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY75_RS10075 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVY75_RS10115 ENOG41080XV Thioredoxin HVY75_RS10125 ENOG4105Q26 Siderophore-interacting protein HVY75_RS10130 ENOG4105NTW Transcriptional regulator HVY75_RS10135 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVY75_RS10145 ENOG4105CBP Major Facilitator HVY75_RS10155 ENOG4105C6F GntR Family Transcriptional Regulator HVY75_RS10160 ENOG4105DEI Mannitol dehydrogenase HVY75_RS10170 ENOG4105Y4Z Outer Membrane Lipoprotein HVY75_RS10180 ENOG4105KT7 mgtC SapB transporter HVY75_RS10185 ENOG4105XXV Acid-resistance protein HVY75_RS10190 ENOG41060V2 Acid-resistance protein HVY75_RS10195 ENOG4108YK4 Acid-resistance membrane protein HVY75_RS10200 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVY75_RS10205 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY75_RS10210 ENOG4105BZS acriflavin resistance protein HVY75_RS10220 ENOG4108NKV transcriptional regulator HVY75_RS10225 ENOG4105D6F Phosphatase HVY75_RS10230 ENOG4108V8F Transcriptional regulator, MarR family HVY75_RS10255 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HVY75_RS10260 ENOG4105FUY alpha subunit HVY75_RS10265 ENOG4107Z7P Ferredoxin HVY75_RS10270 ENOG4105CSP Major Facilitator Superfamily HVY75_RS10275 ENOG4106D80 Uncharacterized protein YhaL HVY75_RS10290 ENOG4105C7B Threonine dehydratase HVY75_RS10295 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVY75_RS10300 ENOG4105CIZ coA-substrate-specific enzyme activase HVY75_RS10310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY75_RS10315 ENOG4105C8Q Methyl-accepting chemotaxis HVY75_RS10325 ENOG4108IA2 Sodium pantothenate symporter HVY75_RS10345 ENOG4108V8F Transcriptional regulator, MarR family HVY75_RS10350 ENOG4105ERH Fumarylacetoacetate hydrolase HVY75_RS10355 ENOG4105C26 Dehydrogenase HVY75_RS10360 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVY75_RS10390 ENOG4105EFA 4-hydroxyphenylacetate HVY75_RS10395 ENOG4107UWN reductase HVY75_RS10400 ENOG4105D22 carbon starvation protein HVY75_RS10405 ENOG4105VCD cytoplasmic protein HVY75_RS10410 ENOG4105CKI cobalamin synthesis protein HVY75_RS10430 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HVY75_RS10435 ENOG4105CVR type I restriction-modification system HVY75_RS10450 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HVY75_RS10455 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC HVY75_RS10470 ENOG4106DIZ Domain of unknown function (DUF1127) HVY75_RS10475 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY75_RS10485 ENOG41083G8 Multidrug resistance protein MdtM HVY75_RS10490 ENOG4106BRA Membrane HVY75_RS10500 ENOG4108YXQ IS66 Orf2 family protein HVY75_RS10510 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVY75_RS10545 ENOG4105C9U ATP-dependent DNA helicase RecQ HVY75_RS10550 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVY75_RS10555 ENOG4108RS6 transposase HVY75_RS10585 ENOG4105DQ4 alcohol dehydrogenase HVY75_RS10590 ENOG4105D7A ATP-binding protein HVY75_RS10595 ENOG4107S21 permease HVY75_RS10600 ENOG4105K4T epimerase HVY75_RS10605 ENOG4107R7Y intracellular protease Pfpi family HVY75_RS10620 ENOG4108YYD acetyltransferase HVY75_RS10640 ENOG4105DEN Luciferase family HVY75_RS10645 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVY75_RS10690 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HVY75_RS10710 ENOG4108K70 Transcriptional regulator HVY75_RS10715 ENOG4105CIC tryptophan-specific transport protein HVY75_RS10720 ENOG4105C1J atp-dependent rna helicase HVY75_RS10760 ENOG4105CHV Transcription elongation factor NusA HVY75_RS10780 ENOG4105DIJ Phosphoethanolamine transferase HVY75_RS10790 ENOG4105NTZ Preprotein translocase subunit SecG HVY75_RS10800 ENOG4105EEI dihydropteroate synthase HVY75_RS10805 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVY75_RS10815 ENOG4105HBR Rna-binding protein HVY75_RS10820 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVY75_RS10825 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVY75_RS10835 ENOG4105QYV Membrane HVY75_RS10850 ENOG4105EAH synthase HVY75_RS10855 ENOG4105HVQ Regulatory factor of maltose metabolism HVY75_RS10865 ENOG4105VFK BolA family HVY75_RS10870 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVY75_RS10875 ENOG4105E3I toluene tolerance HVY75_RS10880 ENOG4107PE3 Mammalian cell entry related domain protein HVY75_RS10885 ENOG4105CY3 ABC transporter, permease HVY75_RS10890 ENOG4105DHJ ABC, transporter HVY75_RS10895 ENOG4105FEU K -dependent Na -Ca exchanger HVY75_RS10900 ENOG4105C2X Arabinose 5-phosphate isomerase HVY75_RS10910 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVY75_RS10915 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVY75_RS10920 ENOG4108IUZ ABC transporter HVY75_RS10925 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY75_RS10930 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVY75_RS10935 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVY75_RS10945 ENOG41080Z8 PHOSPHOCARRIER protein HVY75_RS10950 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVY75_RS10960 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVY75_RS10965 ENOG4105BZU Histidine kinase HVY75_RS10970 ENOG4105N5T Radical SAM Protein HVY75_RS10975 ENOG4105CBC glutamate synthase HVY75_RS10980 ENOG4105BZ8 glutamate synthase HVY75_RS10985 ENOG4105DFS Conserved Protein HVY75_RS10990 ENOG4108R66 Conserved Protein HVY75_RS11020 ENOG4105KB2 stringent starvation protein b HVY75_RS11025 ENOG4107MKT Stringent starvation protein a HVY75_RS11040 ENOG4105D6Z AFG1 family ATPase HVY75_RS11045 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVY75_RS11050 ENOG4105C0H protease HVY75_RS11055 ENOG4105C0H protease HVY75_RS11065 ENOG4107GFK fumarate HVY75_RS11070 ENOG4106DSS Tartrate dehydratase subunit alpha HVY75_RS11075 ENOG4105C8P )-transporter HVY75_RS11085 ENOG4105G3Z GntR family transcriptional regulator HVY75_RS11100 ENOG4105RID UPF0379 protein yhcN HVY75_RS11105 ENOG4105UNR (Barnase) inhibitor HVY75_RS11120 ENOG4105ZQC membrane protein AaeX HVY75_RS11125 ENOG4105CR8 Transcriptional regulator HVY75_RS11130 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVY75_RS11135 ENOG4105QD6 exported protein HVY75_RS11140 ENOG4105C03 ribonuclease HVY75_RS11150 ENOG4105VQ7 Rod shape-determining protein MreD HVY75_RS11155 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVY75_RS11165 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVY75_RS11170 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVY75_RS11185 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVY75_RS11190 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVY75_RS11195 ENOG4105RG0 Membrane HVY75_RS11200 ENOG4108IA2 Sodium pantothenate symporter HVY75_RS11210 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY75_RS11220 ENOG4105CEC DNA methylase N-4 N-6 HVY75_RS11225 ENOG41061ME transport protein HVY75_RS11230 ENOG4108XG4 DNA-binding transcriptional regulator HVY75_RS11235 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY75_RS11240 ENOG4105BZS acriflavin resistance protein HVY75_RS11245 ENOG4105XCM membrane LIPOPROTEIN HVY75_RS11255 ENOG4105EZ7 amino acid ABC transporter HVY75_RS11260 ENOG4105DRP amino acid AbC transporter HVY75_RS11265 ENOG4105CDA abc transporter atp-binding protein HVY75_RS11305 ENOG4108Z0R Transferase HVY75_RS11310 ENOG4105SG3 Protein of unknown function (DUF1488) HVY75_RS11325 ENOG4108WI1 Dna topoisomerase HVY75_RS11335 ENOG4105C79 DNA protecting protein DprA HVY75_RS11355 ENOG4105C1A potassium transporter peripheral membrane HVY75_RS11365 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVY75_RS11370 ENOG4105W1Y Transcriptional regulator HVY75_RS11375 ENOG4105VTS DnaJ-like, subfamily C HVY75_RS11405 ENOG41067V7 50S ribosomal protein L36 HVY75_RS11410 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVY75_RS11455 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVY75_RS11500 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVY75_RS11525 ENOG4108UQY Iron-storage protein HVY75_RS11530 ENOG4105W53 bacterioferritin-associated ferredoxin HVY75_RS11570 ENOG4105WWK YheO domain protein HVY75_RS11575 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY75_RS11585 ENOG4108YZY peptidylprolyl cis-trans isomerase HVY75_RS11590 ENOG4105VKU nucleicacid-binding protein HVY75_RS11605 ENOG4105C5H ABC transporter HVY75_RS11610 ENOG4105DNZ Alpha Beta Hydrolase HVY75_RS11620 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVY75_RS11625 ENOG4108UKZ OsmC family HVY75_RS11635 ENOG410613R integral membrane protein, YccS YhfK family HVY75_RS11640 ENOG4105C8Y Acetylornithine aminotransferase HVY75_RS11645 ENOG4105DDQ anthranilate synthase HVY75_RS11650 ENOG4105MZU cell filamentation protein HVY75_RS11660 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY75_RS11665 ENOG4107QZF nitrite reductase NADPH large subunit HVY75_RS11670 ENOG4105WZK nitrite reductase NADPH small subunit HVY75_RS11675 ENOG4107V9H nitrite transporter HVY75_RS11685 ENOG4105VYH HVY75_RS11690 ENOG4106PKC pyridoxal phosphate binding HVY75_RS11695 ENOG4106M0N transport system permease protein HVY75_RS11700 ENOG4105MUZ Protein of unknown function DUF2620 HVY75_RS11705 ENOG41080QX K07048 phosphotriesterase-related protein HVY75_RS11710 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVY75_RS11715 ENOG4108626 Racemase HVY75_RS11720 ENOG4105RMW regulation of transcription, DNA-dependent HVY75_RS11725 ENOG4108M21 HVY75_RS11730 ENOG4105C31 Tryptophanyl-tRNA synthetase HVY75_RS11735 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVY75_RS11740 ENOG4105DJV ribulose-phosphate 3-epimerase HVY75_RS11745 ENOG4105DFE Dna adenine methylase HVY75_RS11750 ENOG4105EGB membrane protein DamX HVY75_RS11765 ENOG4105E4G Type IV pilus HVY75_RS11770 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVY75_RS11775 ENOG4105XPX DNA utilization protein HofO HVY75_RS11780 ENOG41065NF Fimbrial assembly family protein HVY75_RS11785 ENOG4108U1Q Pilus assembly protein HVY75_RS11790 ENOG4108JQC penicillin-binding protein 1A HVY75_RS11795 ENOG4107RK2 ADP-ribose diphosphatase NudE HVY75_RS11800 ENOG4105DQY intracellular growth attenuator HVY75_RS11805 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVY75_RS11810 ENOG4105VEJ Heat shock protein HVY75_RS11820 ENOG4108MAJ Membrane HVY75_RS11840 ENOG4105E0F Histidine kinase HVY75_RS11850 ENOG4108RRZ Transcription elongation factor GreB HVY75_RS11855 ENOG4105BZM domain protein HVY75_RS11860 ENOG4105XFK Ferrous iron transport protein A HVY75_RS11865 ENOG4105CE1 Ferrous iron transport protein b HVY75_RS11875 ENOG4105DNE Transposase HVY75_RS11885 ENOG4105MJ2 Competence protein HVY75_RS11895 ENOG4105C6Z Gluconate HVY75_RS11905 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVY75_RS11910 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY75_RS11925 ENOG4105E0Y RtcB Protein HVY75_RS11930 ENOG4105CYB regulatoR HVY75_RS11935 ENOG4105E98 transcriptional regulator DeoR family HVY75_RS11950 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVY75_RS11965 ENOG4105CVA phosphate HVY75_RS11970 ENOG4105MHR Fimbrial protein HVY75_RS11975 ENOG4106PH7 chaperone HVY75_RS11985 ENOG4108WDE Fimbrial protein HVY75_RS11990 ENOG4105CW0 outer membrane usher protein HVY75_RS11995 ENOG4108NAE Fimbrial chaperone protein HVY75_RS12005 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY75_RS12030 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY75_RS12035 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVY75_RS12040 ENOG4105C6Z Gluconate HVY75_RS12045 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVY75_RS12050 ENOG4105DIQ Transcriptional regulator HVY75_RS12055 ENOG4105C2I pirin domain protein HVY75_RS12060 ENOG4105D9R oxidoreductase HVY75_RS12065 ENOG4105WCN acetyltransferase HVY75_RS12070 ENOG4105GMB type VI secretion system effector, hcp1 family HVY75_RS12075 ENOG4106FA4 HVY75_RS12080 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVY75_RS12085 ENOG4105WC8 Conserved Protein HVY75_RS12090 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVY75_RS12100 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVY75_RS12105 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVY75_RS12110 ENOG4105BZ7 extracellular solute-binding protein family 1 HVY75_RS12115 ENOG4108IV0 ABC, transporter HVY75_RS12120 ENOG4105C0Z ABC transporter HVY75_RS12125 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVY75_RS12130 ENOG4105C32 Amino acid ABC transporter (Permease) HVY75_RS12135 ENOG4105CP9 extracellular ligand-binding receptor HVY75_RS12140 ENOG4105U59 -acetyltransferase HVY75_RS12145 ENOG4105CP9 extracellular ligand-binding receptor HVY75_RS12150 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY75_RS12155 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVY75_RS12160 ENOG4105CAK Cell division ATP-binding protein ftsE HVY75_RS12165 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVY75_RS12170 ENOG4106H78 methyltransferase HVY75_RS12175 ENOG4105MG3 Membrane HVY75_RS12185 ENOG4107FS9 Membrane HVY75_RS12200 ENOG4105EX9 Membrane HVY75_RS12205 ENOG4108W1V Lipoprotein HVY75_RS12210 ENOG4105F9N Major Facilitator Superfamily HVY75_RS12215 ENOG4105DSF transport protein HVY75_RS12235 ENOG4105E9Q Acyl-transferase HVY75_RS12265 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HVY75_RS12290 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY75_RS12300 ENOG4105C2D reductase HVY75_RS12305 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY75_RS12310 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVY75_RS12320 ENOG4105CMI transporter HVY75_RS12325 ENOG4105CJ1 ABC, transporter HVY75_RS12330 ENOG4105D0S secretion protein (HlyD HVY75_RS12335 ENOG4107UNS conserved inner membrane protein HVY75_RS12360 ENOG4105CBX hi0933 family HVY75_RS12365 ENOG4105CJ3 phosphate transporter HVY75_RS12380 ENOG4105DUX Transporter HVY75_RS12390 ENOG4105DGW oligopeptidase A HVY75_RS12395 ENOG4105D6S protein involved in catabolism of external DNA HVY75_RS12400 ENOG4105DC8 reductase HVY75_RS12415 ENOG4105KBH arsR family transcriptional regulator HVY75_RS12420 ENOG4107R5R arsenical pump membrane protein HVY75_RS12425 ENOG4105K89 arsenate reductase HVY75_RS12445 ENOG4106S2D Transcriptional regulator HVY75_RS12450 ENOG4107H3J ribonuclease HVY75_RS12455 ENOG4105CSH Transporter HVY75_RS12460 ENOG41066T0 asmA family HVY75_RS12465 ENOG4105CMB EAL domain-containing protein HVY75_RS12470 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVY75_RS12485 ENOG4105CS0 peptidase HVY75_RS12495 ENOG4105BZU Histidine kinase HVY75_RS12500 ENOG4105EJG cellulose synthase HVY75_RS12505 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVY75_RS12510 ENOG4107EEX Cellulose synthase regulator protein HVY75_RS12515 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY75_RS12525 ENOG410661M cytoplasmic protein HVY75_RS12530 ENOG4105U74 cellulose biosynthesis protein BcsE HVY75_RS12535 ENOG4105WQA Cellulose biosynthesis protein BcsF HVY75_RS12540 ENOG4105D1V cellulose synthase operon protein YhjU HVY75_RS12560 ENOG4105C28 cystathionine HVY75_RS12565 ENOG4105C44 Serine transporter HVY75_RS12575 ENOG4108JQ7 (ABC) transporter HVY75_RS12580 ENOG4105C3U ABC transporter HVY75_RS12585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY75_RS12590 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY75_RS12595 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY75_RS12610 ENOG4105DIJ Phosphoethanolamine transferase HVY75_RS12615 ENOG4105FCD Major Facilitator HVY75_RS12620 ENOG4105EAX Putative lipase HVY75_RS12625 ENOG4108R3E Dna-3-methyladenine glycosylase i HVY75_RS12630 ENOG4105HNP -acetyltransferase HVY75_RS12635 ENOG4107QY8 reductase HVY75_RS12640 ENOG4108ZG0 Ompa motb domain protein HVY75_RS12645 ENOG4108M60 Transcriptional regulator HVY75_RS12655 ENOG4105D7K pfkb domain protein HVY75_RS12670 ENOG4106JH6 (LipO)protein HVY75_RS12675 ENOG4105D2S major facilitator superfamily HVY75_RS12680 ENOG4105MVF Transcriptional regulator HVY75_RS12695 ENOG41060TC Hok gef cell toxic protein HVY75_RS12720 ENOG4105MEV Acyl-transferase HVY75_RS12725 ENOG410688U Inner membrane protein yiaB HVY75_RS12730 ENOG4105CMG Carbohydrate kinase HVY75_RS12740 ENOG4105T16 Transcriptional regulator (AraC family) HVY75_RS12745 ENOG4108UR8 BAX protein HVY75_RS12750 ENOG4107T9C Alpha amylase catalytic region HVY75_RS12755 ENOG4105JKW Valine--pyruvate aminotransferase HVY75_RS12760 ENOG4108XIB electron transport protein ysaA HVY75_RS12765 ENOG4105J4Q Transcriptional regulator HVY75_RS12775 ENOG4108R66 Conserved Protein HVY75_RS12780 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVY75_RS12785 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY75_RS12790 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY75_RS12795 ENOG4105CMG Carbohydrate kinase HVY75_RS12800 ENOG4105H6Q decarboxylase HVY75_RS12805 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVY75_RS12810 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY75_RS12815 ENOG4105C26 Dehydrogenase HVY75_RS12820 ENOG4105C0A alcohol dehydrogenase HVY75_RS12825 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVY75_RS12835 ENOG4108U78 Glutathione S-transferase HVY75_RS12840 ENOG4105EFX secretion protein, HlyD family HVY75_RS12845 ENOG4105FP6 Protein of unknown function (DUF3302) HVY75_RS12850 ENOG4105CTS PTS system mannitol-specific HVY75_RS12860 ENOG4105E61 Mannitol repressor protein HVY75_RS12870 ENOG4108YYI Protein of unknown function (DUF2810) HVY75_RS12875 ENOG4108WY4 inner membrane lipoprotein HVY75_RS12880 ENOG4105EUR Domain-Containing protein HVY75_RS12885 ENOG4105DAA L-lactate HVY75_RS12890 ENOG41073TP transcriptional regulator HVY75_RS12900 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVY75_RS12905 ENOG4105D7W serine acetyltransferase HVY75_RS12920 ENOG4105VW4 glutaredoxin 3 HVY75_RS12925 ENOG4107YZP Rhodanese domain protein HVY75_RS12935 ENOG41063SB peptidase HVY75_RS12940 ENOG4105PXI polysaccharide deacetylase HVY75_RS12945 ENOG4105K64 Glycosyl transferase, family 2 HVY75_RS12950 ENOG4105D4P Coproporphyrinogen iii oxidase HVY75_RS12955 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVY75_RS12970 ENOG4105C2M dna polymerase I HVY75_RS12975 ENOG4106HNH Acyl-transferase HVY75_RS12985 ENOG4108Z33 Thiol disulfide Interchange Protein HVY75_RS12990 ENOG4105E27 serine threonine protein kinase HVY75_RS12995 ENOG4105PC1 Conserved Protein HVY75_RS13000 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVY75_RS13005 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVY75_RS13035 ENOG4108RR8 protoporphyrinogen oxidase HVY75_RS13040 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY75_RS13045 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVY75_RS13065 ENOG4108MR7 Arylsulfotransferase HVY75_RS13070 ENOG4108EX3 reductase HVY75_RS13075 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY75_RS13080 ENOG4105MDZ Transcriptional activator rfaH HVY75_RS13090 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVY75_RS13095 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVY75_RS13100 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVY75_RS13110 ENOG4105JC1 sterol-binding domain protein HVY75_RS13120 ENOG4105CGY Dna recombination protein HVY75_RS13125 ENOG4107HP6 Transcriptional regulator HVY75_RS13130 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVY75_RS13135 ENOG4108RTU Aldolase HVY75_RS13140 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVY75_RS13155 ENOG4108I5U Uridine phosphorylase HVY75_RS13160 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVY75_RS13185 ENOG4105F04 LysR family Transcriptional regulator HVY75_RS13200 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HVY75_RS13205 ENOG4105C7F AcnD-accessory protein PrpF HVY75_RS13210 ENOG4107QM5 aconitate hydratase HVY75_RS13215 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVY75_RS13220 ENOG4107QIJ Aconitate hydratase 2 HVY75_RS13235 ENOG4105DZ2 Transcriptional regulator HVY75_RS13240 ENOG4105EMK carboxylate amino acid amine transporter HVY75_RS13245 ENOG4105DQF Hydrolase HVY75_RS13250 ENOG4108EUD Lysophospholipase HVY75_RS13255 ENOG410829K Lysine exporter protein (Lyse ygga) HVY75_RS13265 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVY75_RS13270 ENOG4105C9U ATP-dependent DNA helicase RecQ HVY75_RS13280 ENOG4105HDD phospholipase HVY75_RS13285 ENOG4108VUY thioesterase Superfamily protein HVY75_RS13290 ENOG4105FR1 rard protein HVY75_RS13295 ENOG4106WR8 Inner membrane protein YigG HVY75_RS13300 ENOG4105NRM Membrane HVY75_RS13305 ENOG4107QUT magnesium and cobalt transport protein CorA HVY75_RS13310 ENOG4108T58 Mg2 transport protein CorA HVY75_RS13315 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVY75_RS13320 ENOG4105C4R Atp-dependent dna helicase HVY75_RS13325 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVY75_RS13335 ENOG4105CT0 Protein of unknown function, DUF484 HVY75_RS13345 ENOG4105S7Z (LipO)protein HVY75_RS13365 ENOG4107T0K Adenylate cyclase HVY75_RS13375 ENOG41076E6 Uroporphyrinogen-III Synthase HVY75_RS13380 ENOG4105ECF c-methyltransferase HVY75_RS13385 ENOG410601J HemY protein HVY75_RS13395 ENOG4105ENH Sulfatase HVY75_RS13400 ENOG4105C4X radical SAM domain protein HVY75_RS13425 ENOG4105C85 amino acid HVY75_RS13440 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HVY75_RS13445 ENOG4105EGZ biosynthesis protein HVY75_RS13450 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVY75_RS13455 ENOG4108WJ1 acetyltransferase HVY75_RS13460 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY75_RS13465 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY75_RS13470 ENOG4107QQG Dehydrogenase HVY75_RS13475 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVY75_RS13480 ENOG4105SFE lipopolysaccharide biosynthesis protein HVY75_RS13485 ENOG4105ESV Glycosyl transferase, family 4 HVY75_RS13490 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVY75_RS13515 ENOG4105C4R Atp-dependent dna helicase HVY75_RS13520 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVY75_RS13530 ENOG4105EMY transcriptional regulator HVY75_RS13535 ENOG4105C7B Threonine dehydratase HVY75_RS13545 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVY75_RS13550 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVY75_RS13570 ENOG4105C0P Mg chelatase subunit ChlI HVY75_RS13575 ENOG4108WFC UPF0438 protein yifE HVY75_RS13615 ENOG4107EJG GntR family transcriptional regulator HVY75_RS13620 ENOG4105ETE Transcriptional regulator (LacI family HVY75_RS13625 ENOG4108RVA ribokinase HVY75_RS13630 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY75_RS13635 ENOG4105CNN ABC, transporter HVY75_RS13640 ENOG4105C2J ABC transporter HVY75_RS13670 ENOG4108VVK transcriptional Regulator, AsnC HVY75_RS13675 ENOG4105QTB Flavodoxin HVY75_RS13690 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVY75_RS13745 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVY75_RS13750 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVY75_RS13755 ENOG4105C8U phosphate abc transporter HVY75_RS13760 ENOG4105E2Z phosphate ABC transporter (Permease HVY75_RS13765 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVY75_RS13770 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVY75_RS13775 ENOG4105CID antiterminator HVY75_RS13780 ENOG4105C5Y PTS System HVY75_RS13785 ENOG4105CS2 ec 3.2.1.21 HVY75_RS13795 ENOG4105DYC esterase HVY75_RS13800 ENOG4107VKM 6-phosphogluconolactonase HVY75_RS13805 ENOG4106611 bacteriocin immunity HVY75_RS13815 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVY75_RS13820 ENOG4105C7N Xanthine uracil vitamin C permease HVY75_RS13830 ENOG4108YYH Nadph-dependent fmn reductase HVY75_RS13835 ENOG4105E8Q phosphopantetheinyl transferase HVY75_RS13850 ENOG4108P6C Tryptophan transporter of low affinity HVY75_RS13885 ENOG4105VG0 50S ribosomal protein l34 HVY75_RS13900 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVY75_RS13910 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY75_RS13915 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVY75_RS13920 ENOG410667J hydrolase HVY75_RS13925 ENOG410657R replicase EC 2.7 HVY75_RS13930 ENOG4105EMF GntR family transcriptional regulator HVY75_RS13935 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVY75_RS13940 ENOG4108RTU Aldolase HVY75_RS13950 ENOG4105DJB Major Facilitator Superfamily HVY75_RS13960 ENOG4105D99 atp gtp-binding protein HVY75_RS13965 ENOG4105R2A (LipO)protein HVY75_RS13975 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HVY75_RS13980 ENOG4105D0C transport protein HVY75_RS13985 ENOG4105FDP GntR family transcriptional regulator HVY75_RS13990 ENOG4105CI1 PTS System HVY75_RS13995 ENOG4105F8D glycoside hydrolase family 4 HVY75_RS14000 ENOG4105VG5 Membrane HVY75_RS14005 ENOG4105JP4 Inner membrane protein yidG HVY75_RS14010 ENOG4105J13 transcriptional regulator HVY75_RS14025 ENOG4105W8I Transcriptional regulator HVY75_RS14030 ENOG4105E5M Multidrug resistance protein D HVY75_RS14045 ENOG4105C7K acetolactate synthase HVY75_RS14050 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVY75_RS14055 ENOG4108KX4 response regulator HVY75_RS14060 ENOG4105BZU Histidine kinase HVY75_RS14065 ENOG4105CXY transporter HVY75_RS14070 ENOG4105CXY transporter HVY75_RS14080 ENOG4108SAJ Protein of unknown function (DUF1198) HVY75_RS14090 ENOG4105VCP PTS System HVY75_RS14095 ENOG4105CS2 ec 3.2.1.21 HVY75_RS14100 ENOG4105CK1 PTS System HVY75_RS14110 ENOG4105ETE Transcriptional regulator (LacI family HVY75_RS14115 ENOG4105T8A Uncharacterized protein YicS HVY75_RS14120 ENOG4108UZ3 Transporter HVY75_RS14190 ENOG4105DFP Integrase HVY75_RS14200 ENOG4105CT4 transporter HVY75_RS14205 ENOG4105CJQ hydrolase, family 31 HVY75_RS14210 ENOG4105JV1 AsmA family HVY75_RS14215 ENOG4105C2W permease HVY75_RS14220 ENOG4105D6U Sodium Glutamate Symporter HVY75_RS14230 ENOG4105CB5 ATP-dependent DNA helicase recG HVY75_RS14235 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVY75_RS14240 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY75_RS14250 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVY75_RS14260 ENOG4105EN6 Membrane HVY75_RS14265 ENOG4105DSJ YicC domain protein HVY75_RS14280 ENOG4107RRE RNA-directed DNA polymerase HVY75_RS14290 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVY75_RS14295 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVY75_RS14305 ENOG4105KDC 50s ribosomal protein l28 HVY75_RS14325 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVY75_RS14330 ENOG4105DKP glycosyl transferase, family 9 HVY75_RS14335 ENOG4107RJ7 Glycosyl transferase (Group 1 HVY75_RS14340 ENOG4107543 (lipo)polysaccharide HVY75_RS14345 ENOG410650X lipopolysaccharide core region biosynthetic process HVY75_RS14350 ENOG4107XU6 Glycosyl transferase (Group 1 HVY75_RS14355 ENOG4106AH0 Glycosyl Transferase HVY75_RS14360 ENOG4105X1N Glycosyl transferase family 8 HVY75_RS14365 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVY75_RS14370 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVY75_RS14375 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HVY75_RS14380 ENOG4108FRV O-antigen ligase HVY75_RS14385 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVY75_RS14390 ENOG4105XA0 heptosyltransferase ii HVY75_RS14400 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVY75_RS14410 ENOG4106FIY HVY75_RS14415 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY75_RS14420 ENOG4105CUX Signal transduction histidine kinase HVY75_RS14425 ENOG4105C5F glutamine synthetase HVY75_RS14430 ENOG4105CI3 gtp-binding protein typa HVY75_RS14435 ENOG4108K4B hydrolase HVY75_RS14445 ENOG4105CSA Coproporphyrinogen iii oxidase HVY75_RS14465 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVY75_RS14480 ENOG4105SUU thioesterase domain HVY75_RS14510 ENOG4108MG3 formate dehydrogenase HVY75_RS14515 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY75_RS14530 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HVY75_RS14540 ENOG4108V87 frv operon regulatory protein HVY75_RS14550 ENOG4106C3V frv operon regulatory protein HVY75_RS14555 ENOG4105CN9 Peptidase m42 family protein HVY75_RS14560 ENOG4105DM4 PTS System HVY75_RS14565 ENOG41064BA PTS system, fructose-specific, IIA component HVY75_RS14575 ENOG4105C0A alcohol dehydrogenase HVY75_RS14610 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY75_RS14615 ENOG4108RPX mosc domain containing protein HVY75_RS14620 ENOG4105E0F Histidine kinase HVY75_RS14625 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY75_RS14630 ENOG4105FMW periplasmic HVY75_RS14645 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVY75_RS14660 ENOG4105EBK exported protein HVY75_RS14665 ENOG4108VTS Membrane HVY75_RS14670 ENOG41065TG regulatoR HVY75_RS14680 ENOG4105DP0 ferredoxin-NADP reductase HVY75_RS14685 ENOG4105CBT Fructose-1,6-bisphosphatase HVY75_RS14695 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY75_RS14710 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVY75_RS14725 ENOG41063M6 Cell Division Protein HVY75_RS14730 ENOG4105ETE Transcriptional regulator (LacI family HVY75_RS14735 ENOG4105C25 Primosomal protein n' HVY75_RS14750 ENOG4107S01 Repressor protein MetJ HVY75_RS14760 ENOG4105C28 cystathionine HVY75_RS14765 ENOG4105CFH Aspartokinase HVY75_RS14775 ENOG4105CGH 5'-nucleotidase HVY75_RS14780 ENOG4105SYT Methylenetetrahydrofolate reductase HVY75_RS14790 ENOG4108Q5Y Membrane HVY75_RS14795 ENOG4108XC3 NADH ubiquinone oxidoreductase HVY75_RS14800 ENOG4105DCT glycerol dehydrogenase HVY75_RS14805 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY75_RS14810 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY75_RS14815 ENOG4105DM4 PTS System HVY75_RS14820 ENOG4108YRF PTS System HVY75_RS14830 ENOG4108AHH pyruvate formate lyase II activase HVY75_RS14835 ENOG4108XCZ PTS System HVY75_RS14840 ENOG4106R3P AraC family transcriptional regulator HVY75_RS14845 ENOG4105DIJ Phosphoethanolamine transferase HVY75_RS14860 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVY75_RS14875 ENOG4105C5Q Transcriptional regulator HVY75_RS14885 ENOG4105CH2 amidohydrolase HVY75_RS14895 ENOG4105EJ2 Transcriptional regulator HVY75_RS14900 ENOG4108Y73 Membrane HVY75_RS14940 ENOG4105D4A Cell wall formation (By similarity) HVY75_RS14945 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVY75_RS14980 ENOG4105PM1 preprotein translocase subunit SecE HVY75_RS14985 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVY75_RS15020 ENOG4105D41 biosynthesis protein thiH HVY75_RS15030 ENOG4105WHD thiamine biosynthesis protein ThiS HVY75_RS15035 ENOG4105D06 uba thif-type nad fad binding protein HVY75_RS15070 ENOG4105R2J Conserved Protein HVY75_RS15080 ENOG4108T8B Protein of unknown function (DUF1481) HVY75_RS15085 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVY75_RS15090 ENOG4105BZU Histidine kinase HVY75_RS15095 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY75_RS15100 ENOG4105C12 Phosphoribosylglycinamide synthetase HVY75_RS15130 ENOG4105K5X acetyltransferase HVY75_RS15140 ENOG4107QP3 malate synthase g HVY75_RS15145 ENOG4108I9X Isocitrate lyase HVY75_RS15160 ENOG41069M3 Transcriptional regulator HVY75_RS15165 ENOG4105C3R Methionine synthase HVY75_RS15180 ENOG4105EAM Na Pi-cotransporter HVY75_RS15185 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVY75_RS15190 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY75_RS15195 ENOG4105F3R pts system mannose fructose sorbose family iid HVY75_RS15200 ENOG4105ETZ PTS System HVY75_RS15205 ENOG4105KPI PTS system sorbose subfamily IIB component HVY75_RS15210 ENOG4108XCU pts system HVY75_RS15215 ENOG4105CHR reductase HVY75_RS15220 ENOG4105DKT Transcriptional regulator HVY75_RS15225 ENOG4105FE9 pseudouridine synthase HVY75_RS15230 ENOG4108ZR5 Conserved Protein HVY75_RS15240 ENOG410756H nucleotidyltransferase HVY75_RS15260 ENOG410685N tail fiber protein HVY75_RS15340 ENOG4107SC1 transglycosylase HVY75_RS15355 ENOG4108WZA zeta toxin HVY75_RS15360 ENOG4105CFH Aspartokinase HVY75_RS15365 ENOG4107QP8 phosphohexose isomerase HVY75_RS15375 ENOG4108MDC (LipO)protein HVY75_RS15380 ENOG4108Q9C Periplasmic Protein HVY75_RS15385 ENOG4105E3R (LipO)protein HVY75_RS15395 ENOG4107QNK )-transporter HVY75_RS15400 ENOG4105EG2 ABC transporter, permease HVY75_RS15405 ENOG4105D56 permease protein HVY75_RS15410 ENOG4107FKK extracellular solute-binding protein family 1 HVY75_RS15415 ENOG4108IJ9 (ABC) transporter HVY75_RS15425 ENOG4107W52 maltose operon periplasmic protein HVY75_RS15445 ENOG41080IJ Diacylglycerol kinase HVY75_RS15455 ENOG4107R73 Mate efflux family protein HVY75_RS15460 ENOG4105VDW Csbd family HVY75_RS15465 ENOG4105MYN Zinc uptake regulation protein HVY75_RS15470 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY75_RS15475 ENOG4105P4Z Phage shock protein G HVY75_RS15480 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVY75_RS15485 ENOG4105CDU Replicative dna helicase HVY75_RS15495 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY75_RS15500 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY75_RS15505 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVY75_RS15510 ENOG4105CGF Aromatic amino acid aminotransferase HVY75_RS15515 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVY75_RS15520 ENOG4105C7S Dehydrogenase HVY75_RS15525 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY75_RS15530 ENOG4105CMV Succinyl-CoA synthetase subunit beta HVY75_RS15535 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVY75_RS15540 ENOG4107QPK )-transporter HVY75_RS15545 ENOG4105DG4 malate L-lactate dehydrogenase HVY75_RS15550 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY75_RS15560 ENOG4105F0S class B acid phosphatase HVY75_RS15565 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVY75_RS15570 ENOG4105MSB protein, conserved in bacteria HVY75_RS15575 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVY75_RS15580 ENOG4108UUM single-stranded DNA-binding protein HVY75_RS15585 ENOG4105PMV Membrane HVY75_RS15590 ENOG4108W3Q Transcriptional regulator HVY75_RS15595 ENOG4108Z4X TRANSCRIPTIONal HVY75_RS15600 ENOG4105C7N Xanthine uracil vitamin C permease HVY75_RS15605 ENOG4105EEQ Na H antiporter HVY75_RS15610 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVY75_RS15615 ENOG4108F5E vimentin HVY75_RS15620 ENOG4108YIV HVY75_RS15625 ENOG4105CSH Transporter HVY75_RS15630 ENOG4105ECM Sensor protein basS pmrB HVY75_RS15635 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY75_RS15640 ENOG4105DIJ Phosphoethanolamine transferase HVY75_RS15645 ENOG4106ZGR Transcriptional regulator HVY75_RS15650 ENOG4108R5S membrane HVY75_RS15655 ENOG4107GFK fumarate HVY75_RS15660 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY75_RS15665 ENOG4108MRH transcriptional regulatory protein HVY75_RS15670 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY75_RS15690 ENOG4105QAX Iron-sulfur HVY75_RS15695 ENOG4107KGK dmso reductase anchor subunit HVY75_RS15700 ENOG4108NEM leader-binding protein dmsD HVY75_RS15720 ENOG4108SIC Transcriptional regulator HVY75_RS15725 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVY75_RS15735 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY75_RS15740 ENOG4108IJ0 Aspartate ammonia-lyase HVY75_RS15745 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVY75_RS15750 ENOG4105DVH amino acid HVY75_RS15765 ENOG4108ZVF (LipO)protein HVY75_RS15770 ENOG4105MTB Uncharacterized protein YjeJ HVY75_RS15775 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVY75_RS15785 ENOG4107PEH Entericidin EcnA/B family HVY75_RS15790 ENOG4106BSU Entericidin B HVY75_RS15795 ENOG4105KPY Small multidrug resistance protein HVY75_RS15800 ENOG4105QNF Outer membrane lipoprotein HVY75_RS15805 ENOG41066YJ Beta-lactamase HVY75_RS15820 ENOG4105E33 succinate dehydrogenase HVY75_RS15825 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY75_RS15835 ENOG4107SC7 Inner membrane transporter yjeM HVY75_RS15840 ENOG4106V5W HVY75_RS15845 ENOG4106CG8 Inner membrane protein YjeO HVY75_RS15850 ENOG4105EGS Mechanosensitive ion channel HVY75_RS15870 ENOG4106TNF Periplasmic binding protein HVY75_RS15895 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVY75_RS15900 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVY75_RS15905 ENOG4105K8N protein family UPF0079, ATPase HVY75_RS15910 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY75_RS15930 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVY75_RS15935 ENOG4107QJR hflk protein HVY75_RS15940 ENOG4105EPW hflc protein HVY75_RS15960 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVY75_RS15965 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVY75_RS15970 ENOG4105FUX Conserved Protein HVY75_RS15975 ENOG4108P9J Phage shock protein A HVY75_RS15980 ENOG4107VNS Protein of unknown function (DUF2491) HVY75_RS15985 ENOG4105Z6B inner membrane protein yjfl HVY75_RS15990 ENOG4108KXT Conserved Protein HVY75_RS15995 ENOG4106032 Glutathionylspermidine synthase HVY75_RS16000 ENOG4105CSU acyl-Coa dehydrogenase HVY75_RS16005 ENOG4105S17 UPF0379 protein yjfN HVY75_RS16010 ENOG4105WSB biofilm stress and motility protein A HVY75_RS16015 ENOG4108MXZ Esterase HVY75_RS16020 ENOG4105DW5 Transcriptional regulator HVY75_RS16030 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY75_RS16035 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVY75_RS16060 ENOG4105KIT UPF0379 protein yjfY HVY75_RS16075 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVY75_RS16085 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY75_RS16090 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY75_RS16095 ENOG41069H7 transport system small permease component HVY75_RS16100 ENOG4107S3R L-aspartate oxidase HVY75_RS16105 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVY75_RS16110 ENOG4105E39 Enoyl-CoA hydratase HVY75_RS16120 ENOG4105CHR reductase HVY75_RS16130 ENOG4105FHY Opacity-associated protein A HVY75_RS16135 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY75_RS16150 ENOG4105DXC membrane HVY75_RS16155 ENOG4105ECR NmrA family HVY75_RS16160 ENOG4105KVH Transcriptional regulator HVY75_RS16165 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVY75_RS16170 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVY75_RS16175 ENOG4108UUE Transcriptional regulator HVY75_RS16180 ENOG41061GZ Protein of unknown function (DUF1107) HVY75_RS16185 ENOG4105C37 (CBS) domain HVY75_RS16190 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVY75_RS16200 ENOG4108YZG isomerase HVY75_RS16205 ENOG4105NYY transcriptional regulator, RpiR HVY75_RS16210 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY75_RS16215 ENOG4105C2J ABC transporter HVY75_RS16220 ENOG4105CNN ABC, transporter HVY75_RS16225 ENOG4105UP7 3-epimerase HVY75_RS16230 ENOG4107TFG D-allose kinase HVY75_RS16235 ENOG4105EUZ Beta-lactamase domain protein HVY75_RS16245 ENOG4105J12 Multidrug resistance protein mdtN HVY75_RS16250 ENOG4108MI0 Resistance protein HVY75_RS16255 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVY75_RS16265 ENOG41082ND Uncharacterized protein yjcO HVY75_RS16270 ENOG4105CK2 sodium dicarboxylate symporter HVY75_RS16275 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY75_RS16280 ENOG41062QD Membrane HVY75_RS16295 ENOG4105CFU surface antigen HVY75_RS16300 ENOG4105MA0 exported protein HVY75_RS16305 ENOG4108ZHD aig2 family HVY75_RS16310 ENOG4105F0N pyrophosphate phospho-hydrolase HVY75_RS16315 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVY75_RS16320 ENOG4105C2J ABC transporter HVY75_RS16325 ENOG4107R9N ABC transporter HVY75_RS16330 ENOG41062B0 ABC transporter, permease HVY75_RS16340 ENOG4105DFU Cell wall formation (By similarity) HVY75_RS16345 ENOG4105N42 UPF0307 protein HVY75_RS16350 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVY75_RS16355 ENOG4108XVM Cytochrome b(562) HVY75_RS16365 ENOG4105K4U addiction module toxin, RelE StbE family HVY75_RS16370 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVY75_RS16375 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVY75_RS16380 ENOG4105CG3 alpha amylase, catalytic region HVY75_RS16385 ENOG4105C5Y PTS System HVY75_RS16390 ENOG4105D4X repressor HVY75_RS16400 ENOG4105KME endoribonuclease L-psp HVY75_RS16415 ENOG4107C93 pyrBI operon leader peptide HVY75_RS16425 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVY75_RS16430 ENOG4105DBV ornithine carbamoyltransferase HVY75_RS16445 ENOG4105XEP YhcH YjgK YiaL family protein HVY75_RS16450 ENOG4105DBV ornithine carbamoyltransferase HVY75_RS16455 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVY75_RS16460 ENOG4108MJ3 acetyltransferase HVY75_RS16465 ENOG4108M3P Membrane HVY75_RS16470 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVY75_RS16475 ENOG4105MYG DNA polymerase iii, chi subunit HVY75_RS16490 ENOG4108M8S permease YjgP YjgQ family protein HVY75_RS16495 ENOG4108K5H permease YjgP YjgQ family protein HVY75_RS16500 ENOG4105W4M Transport-associated protein HVY75_RS16520 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVY75_RS16525 ENOG4106HBN Galactosamine-6-phosphate isomerase HVY75_RS16530 ENOG4105F3R pts system mannose fructose sorbose family iid HVY75_RS16535 ENOG4105ETZ PTS System HVY75_RS16540 ENOG4108UZY PTS System HVY75_RS16550 ENOG4105E70 isomerase HVY75_RS16555 ENOG4105CE4 GlcNAc 6-P deacetylase HVY75_RS16560 ENOG4108YTN IIa component HVY75_RS16565 ENOG4105F3R pts system mannose fructose sorbose family iid HVY75_RS16575 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVY75_RS16585 ENOG4105E98 transcriptional regulator DeoR family HVY75_RS16590 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HVY75_RS16595 ENOG4105ZEG Suppressor protein HVY75_RS16600 ENOG4105CTX dehydratase HVY75_RS16610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY75_RS16620 ENOG4108CNN domain protein HVY75_RS16625 ENOG4105CWB LysR family transcriptional Regulator HVY75_RS16630 ENOG4105KAF membrAne HVY75_RS16635 ENOG4105CHF Glutathione S-transferase HVY75_RS16640 ENOG4108VBZ doxx family HVY75_RS16645 ENOG4105YJD HVY75_RS16650 ENOG41090KG Inner membrane protein YqjE HVY75_RS16655 ENOG4105NE1 Conserved Protein HVY75_RS16660 ENOG4105WAY exported protein HVY75_RS16670 ENOG4106W5V Membrane HVY75_RS16675 ENOG4107YCY Transcriptional regulator HVY75_RS16680 ENOG4105DPW Major facilitator superfamily MFS_1 HVY75_RS16690 ENOG4105CTX dehydratase HVY75_RS16695 ENOG4105P66 Membrane HVY75_RS16700 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVY75_RS16705 ENOG4105DU1 integral membrane protein, terc HVY75_RS16710 ENOG4105EE0 oxidoreductase HVY75_RS16715 ENOG4108UB4 uncharacterized protein ygjQ HVY75_RS16720 ENOG4108VKG metal-dependent hydrolase HVY75_RS16740 ENOG4105RI1 glycoprotein receptor HVY75_RS16745 ENOG4106CVF DNA replication protein HVY75_RS16750 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HVY75_RS16755 ENOG4107XM3 UPF0442 protein HVY75_RS16760 ENOG4105DWK Membrane HVY75_RS16765 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HVY75_RS16770 ENOG4105EZV Transcriptional regulator HVY75_RS16775 ENOG4108N8T regulatoR HVY75_RS16780 ENOG4108T94 DNA-binding transcriptional activator BglJ HVY75_RS16785 ENOG4108819 ferric iron reductase HVY75_RS16790 ENOG4105YBH Protein of unknown function (DUF1435) HVY75_RS16820 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVY75_RS16825 ENOG4108WPU DNA polymerase III subunit psi HVY75_RS16830 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVY75_RS16835 ENOG4105PAD Hydrolase HVY75_RS16845 ENOG4105K3G Periplasmic Protein HVY75_RS16855 ENOG4108NRW Phospholipase, patatin family HVY75_RS16860 ENOG4105EYA deoxyribonuclease HVY75_RS16865 ENOG41076CZ activating enzyme HVY75_RS16870 ENOG4105G0K glycine radical enzyme YjjI family HVY75_RS16905 ENOG41062Z9 Membrane HVY75_RS16910 ENOG4105EAC phosphoserine phosphatase HVY75_RS16915 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVY75_RS16920 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVY75_RS16925 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HVY75_RS16935 ENOG4105C5H ABC transporter HVY75_RS16940 ENOG4107SC1 transglycosylase HVY75_RS16950 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVY75_RS16960 ENOG4105UEI Transcriptional Regulator AraC Family HVY75_RS16965 ENOG4108RH0 Crea protein HVY75_RS16975 ENOG4105EB3 Histidine kinase HVY75_RS16980 ENOG4105CT7 inner membrane cred family protein HVY75_RS16985 ENOG41065U4 response regulator HVY75_RS16990 ENOG410759A HVY75_RS16995 ENOG4106FVC RNA methyltransferase HVY75_RS17005 ENOG4105CFH Aspartokinase HVY75_RS17015 ENOG4105D98 threonine synthase HVY75_RS17020 ENOG41062C6 Protein of unknown function (DUF2502) HVY75_RS17030 ENOG4105BZG amino acid carrier protein HVY75_RS17040 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY75_RS17045 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVY75_RS17060 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVY75_RS17070 ENOG41063Z6 transcriptional regulator, lysR family HVY75_RS17080 ENOG410647N response to DNA damage stimulus HVY75_RS17085 ENOG4105DTN riboflavin biosynthesis protein ribF HVY75_RS17090 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HVY75_RS17100 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVY75_RS17120 ENOG4106YYS transcriptional regulatory protein HVY75_RS17125 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY75_RS17130 ENOG4105D9Q decarboxylase (Beta subunit) HVY75_RS17135 ENOG4107QSA Oxaloacetate decarboxylase HVY75_RS17145 ENOG4105D2K citrate carrier protein HVY75_RS17150 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVY75_RS17160 ENOG4105CI0 Citrate lyase HVY75_RS17165 ENOG4105CHY citrate lyase, alpha HVY75_RS17190 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVY75_RS17195 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVY75_RS17200 ENOG4108XNW Transcriptional activatory protein CaiF HVY75_RS17210 ENOG4106YT9 Enoyl-CoA hydratase HVY75_RS17245 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVY75_RS17250 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVY75_RS17255 ENOG4105C54 Major Facilitator superfamily HVY75_RS17270 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVY75_RS17310 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVY75_RS17320 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVY75_RS17325 ENOG4105D3G Pseudouridine synthase HVY75_RS17330 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVY75_RS17335 ENOG4105CQ2 DNA polymerase HVY75_RS17340 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY75_RS17360 ENOG4108RVA ribokinase HVY75_RS17385 ENOG4108KF1 Membrane HVY75_RS17395 ENOG4106SMU thiamine transporter membrane protein HVY75_RS17400 ENOG4105DP9 ABC transporter HVY75_RS17405 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HVY75_RS17415 ENOG4105S8Q sugar efflux transporter HVY75_RS17420 ENOG4105DJB Major Facilitator Superfamily HVY75_RS17425 ENOG4105DND Transcriptional regulator HVY75_RS17430 ENOG4105FF2 Type I DHQase HVY75_RS17435 ENOG4105EMV Major Facilitator HVY75_RS17450 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HVY75_RS17475 ENOG41064T2 transcriptional regulator, lysR family HVY75_RS17480 ENOG4105C7K acetolactate synthase HVY75_RS17485 ENOG4108ZP8 Acetolactate synthase small subunit HVY75_RS17495 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVY75_RS17510 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVY75_RS17515 ENOG4105CJN penicillin-binding protein HVY75_RS17520 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVY75_RS17525 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVY75_RS17535 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVY75_RS17540 ENOG4105CNI cell division protein FtsW HVY75_RS17555 ENOG4105CPF Cell wall formation (By similarity) HVY75_RS17560 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVY75_RS17565 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVY75_RS17570 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVY75_RS17590 ENOG4105M6F mutator MutT protein HVY75_RS17605 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVY75_RS17615 ENOG4105D7Q type ii secretion system HVY75_RS17620 ENOG4107QHF type ii secretion system protein e HVY75_RS17625 ENOG4108ZUW Major pilin subunit HVY75_RS17630 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVY75_RS17635 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY75_RS17640 ENOG4106A72 regulatory protein AmpE HVY75_RS17645 ENOG4105C85 amino acid HVY75_RS17650 ENOG41073TP transcriptional regulator HVY75_RS17655 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVY75_RS17660 ENOG4107QSN dihydrolipoamide acetyltransferase HVY75_RS17665 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY75_RS17670 ENOG4108NST exported protein HVY75_RS17675 ENOG4107QIJ Aconitate hydratase 2 HVY75_RS17695 ENOG4108ZRK uncharacterized protein yacC HVY75_RS17700 ENOG4105E3B Multicopper oxidase HVY75_RS17705 ENOG4105DZG Dehydrogenase HVY75_RS17710 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVY75_RS17715 ENOG41077A9 carbonic anhydrase HVY75_RS17720 ENOG4105DA5 (ABC) transporter HVY75_RS17725 ENOG4105E3A (ABC) transporter HVY75_RS17730 ENOG4108YTN IIa component HVY75_RS17735 ENOG4107BJW polysaccharide deacetylase HVY75_RS17745 ENOG4108A32 Transposase HVY75_RS17760 ENOG4105P0Q fimbrial-like protein YadC HVY75_RS17765 ENOG4105SN2 fimbrial-like adhesin protein HVY75_RS17770 ENOG4105SYG Fimbrial protein HVY75_RS17775 ENOG4108XEY fimbrial-like adhesin protein HVY75_RS17780 ENOG4105CW0 outer membrane usher protein HVY75_RS17785 ENOG4108VEV chaperone HVY75_RS17795 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVY75_RS17800 ENOG4105DJ0 Poly(A) Polymerase HVY75_RS17820 ENOG4107XID 2'-5' rna ligase HVY75_RS17825 ENOG4105CQ7 ATP-dependent helicase HVY75_RS17830 ENOG4105BZ4 penicillin-binding protein HVY75_RS17835 ENOG4105E0K tonB-dependent siderophore receptor HVY75_RS17840 ENOG4105E0A ABC, transporter HVY75_RS17845 ENOG4105J76 Periplasmic binding protein HVY75_RS17850 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVY75_RS17875 ENOG4105EN6 Membrane HVY75_RS17880 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVY75_RS17895 ENOG4105C0H protease HVY75_RS17900 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVY75_RS17910 ENOG4105DIN metallophosphoesterase HVY75_RS17925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVY75_RS17950 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVY75_RS17955 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVY75_RS17960 ENOG4105KNE Phosphatidate cytidylyltransferase HVY75_RS17965 ENOG4105DZP Membrane-associated zinc metalloprotease HVY75_RS17975 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVY75_RS17980 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVY75_RS18005 ENOG4105C0B DNA polymerase III (alpha subunit) HVY75_RS18010 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HVY75_RS18015 ENOG4105CXN decarboxylase HVY75_RS18020 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVY75_RS18025 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVY75_RS18030 ENOG4105M1T rho-binding antiterminator HVY75_RS18040 ENOG4108VWS Yaeq family HVY75_RS18045 ENOG4108YZN class I peptide chain release factor HVY75_RS18050 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVY75_RS18055 ENOG4108UY0 (LipO)protein HVY75_RS18065 ENOG4108R96 Methyltransferase, YaeB family HVY75_RS18070 ENOG4108R8X outer membrane lipoprotein HVY75_RS18075 ENOG4105D01 (LipO)protein HVY75_RS18080 ENOG4108UMI ABC transporter, permease HVY75_RS18085 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVY75_RS18090 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVY75_RS18125 ENOG4105CV8 reductase HVY75_RS18130 ENOG4105HEI LysR family (Transcriptional regulator HVY75_RS18140 ENOG4105F2W methyltransferase HVY75_RS18145 ENOG4105E9H Lytic Murein transglycosylase HVY75_RS18155 ENOG4105D1A Methyltransferase HVY75_RS18165 ENOG4107RZZ dna polymerase iii epsilon subunit HVY75_RS18175 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY75_RS18180 ENOG4108WN0 inhibitor of vertebrate lysozyme HVY75_RS18185 ENOG4107QPN acyl-Coa dehydrogenase HVY75_RS18195 ENOG4105E7A Glutamine amidotransferase HVY75_RS18200 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVY75_RS18205 ENOG4108YS0 lipoprotein YafL HVY75_RS18215 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY75_RS18235 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVY75_RS18240 ENOG4105CUZ uba thif-type nad fad binding protein HVY75_RS18245 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVY75_RS18250 ENOG4105C9B Cysteine desulfurase HVY75_RS18255 ENOG4105M5B (LipO)protein HVY75_RS18260 ENOG4105ETT transcriptional Regulator, LysR family HVY75_RS18265 ENOG4105M08 Membrane HVY75_RS18280 ENOG4105EJQ L-serine dehydratase HVY75_RS18285 ENOG4105C44 Serine transporter HVY75_RS18290 ENOG4105EWT decarboxylase family HVY75_RS18305 ENOG4105WP7 tRNA pseudouridine synthase C HVY75_RS18310 ENOG4105DR9 pseudouridine synthase HVY75_RS18315 ENOG4105QDK Flavodoxin HVY75_RS18320 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVY75_RS18335 ENOG4105EQX glucarate dehydratase HVY75_RS18340 ENOG4105EQX glucarate dehydratase HVY75_RS18345 ENOG4105BZW Glycerate kinase HVY75_RS18350 ENOG4105BZU Histidine kinase HVY75_RS18355 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVY75_RS18360 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY75_RS18365 ENOG4105DXN mazG family HVY75_RS18380 ENOG4105HA9 of methanol dehydrogenase type HVY75_RS18390 ENOG4105HA9 of methanol dehydrogenase type HVY75_RS18400 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVY75_RS18410 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVY75_RS18430 ENOG4107635 Hok Gef family protein HVY75_RS18435 ENOG4105DTT CRISPR-associated helicase, cas3 HVY75_RS18450 ENOG41060M0 Crispr-associated protein, cse4 family HVY75_RS18455 ENOG4108VWQ crispr-associated protein HVY75_RS18465 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVY75_RS18470 ENOG4105PWE CRISPR-associated protein cas2 HVY75_RS18475 ENOG4108MXK alkaline phosphatase isozyme conversion HVY75_RS18495 ENOG4105N0Z inner membrane protein ygbE HVY75_RS18530 ENOG4108K5P (LipO)protein HVY75_RS18535 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY75_RS18545 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY75_RS18550 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY75_RS18555 ENOG4105KZM cytoplasmic protein HVY75_RS18560 ENOG4105MEW serine threonine protein phosphatase HVY75_RS18580 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVY75_RS18595 ENOG4105C2J ABC transporter HVY75_RS18600 ENOG4105CNN ABC, transporter HVY75_RS18605 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY75_RS18610 ENOG4107EDW L-fucose operon activator HVY75_RS18615 ENOG4105VXR cytoplasmic protein HVY75_RS18620 ENOG4105F4R Transcriptional regulator mode HVY75_RS18625 ENOG4108JUA Transcriptional regulator HVY75_RS18630 ENOG4105C45 hydrogenase expression formation protein (HypE) HVY75_RS18635 ENOG4105CQS hydrogenase expression formation protein HypD HVY75_RS18640 ENOG41083WG hydrogenase assembly chaperone HVY75_RS18645 ENOG4107RSS Hydrogenase accessory protein HypB HVY75_RS18650 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVY75_RS18655 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVY75_RS18660 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY75_RS18665 ENOG4107R30 NADH dehydrogenase HVY75_RS18670 ENOG4107TDF Formate hydrogenlyase subunit 4 HVY75_RS18675 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY75_RS18680 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVY75_RS18685 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY75_RS18690 ENOG4105I6X formate hydrogenlyase maturation HVY75_RS18695 ENOG4108MG9 hydrogenase 3 maturation protease HVY75_RS18700 ENOG4105CS2 ec 3.2.1.21 HVY75_RS18705 ENOG4105C5Y PTS System HVY75_RS18710 ENOG4105DDV Transcriptional regulator (LacI family HVY75_RS18715 ENOG4108RC0 Electron transport protein HVY75_RS18720 ENOG4105C8H hydrogenase maturation protein Hypf HVY75_RS18740 ENOG4105C2X Arabinose 5-phosphate isomerase HVY75_RS18750 ENOG4105CVE Lytic murein transglycosylase HVY75_RS18760 ENOG4107TH8 cina domain protein HVY75_RS18780 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVY75_RS18810 ENOG4107VXZ Hydrolase HVY75_RS18815 ENOG4105W39 Membrane HVY75_RS18840 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY75_RS18845 ENOG4105CW7 secretion protein, HlyD family HVY75_RS18850 ENOG4105NTK Transcriptional repressor Mpra HVY75_RS18855 ENOG4105ZED uncharacterized protein ygaH HVY75_RS18860 ENOG4108UMN azlc family HVY75_RS18870 ENOG4105GIJ Glycine betaine HVY75_RS18875 ENOG4108HQS Glycine betaine HVY75_RS18880 ENOG4108IJ7 Glycine betaine HVY75_RS18885 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY75_RS18890 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY75_RS18900 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVY75_RS18905 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY75_RS18915 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVY75_RS18920 ENOG4108WMJ Protein of unknown function (DUF2002) HVY75_RS18930 ENOG4108X73 DNA- binding protein HVY75_RS18935 ENOG4108V62 Rhodanese domain protein HVY75_RS18940 ENOG41080HT Transcriptional regulator, arsr family HVY75_RS18945 ENOG4105VPI YqaE family transport protein HVY75_RS18950 ENOG4109066 lysm domain bon superfamily protein HVY75_RS18955 ENOG4108PVQ transcriptional regulator HVY75_RS18960 ENOG4105C85 amino acid HVY75_RS18965 ENOG4108JPW Aminotransferase HVY75_RS18970 ENOG4105C26 Dehydrogenase HVY75_RS18975 ENOG4105D5U fad dependent oxidoreductase HVY75_RS18985 ENOG4108NUU Transcriptional regulator HVY75_RS18990 ENOG4105SZ2 membrAne HVY75_RS18995 ENOG4107SNB ankyrin repeat protein YahD HVY75_RS19000 ENOG4105N16 Protein of unknown function (DUF2877) HVY75_RS19005 ENOG4107R1Q Membrane protein FdrA HVY75_RS19010 ENOG4107REC cytoplasmic protein HVY75_RS19015 ENOG4105C5B carbamate kinase HVY75_RS19020 ENOG4105DZC cytosine deaminase HVY75_RS19025 ENOG4105DTA methyltransferase HVY75_RS19035 ENOG4105DQ4 alcohol dehydrogenase HVY75_RS19040 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY75_RS19045 ENOG4108YZG isomerase HVY75_RS19055 ENOG4105CMT Dihydroxyacetone kinase HVY75_RS19060 ENOG4105CP7 Triose-phosphate isomerase HVY75_RS19065 ENOG4108KFM Xylose Isomerase Domain-Containing protein HVY75_RS19070 ENOG4106J7G oxidoreductase HVY75_RS19075 ENOG4105DKT Transcriptional regulator HVY75_RS19080 ENOG41083A2 UPF0145 protein HVY75_RS19085 ENOG4105Y50 Virulence Protein HVY75_RS19100 ENOG4108Z1B Cyclase dehydrase HVY75_RS19110 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY75_RS19115 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVY75_RS19130 ENOG4108JU6 CBS domain protein HVY75_RS19135 ENOG4106KVJ cytochrome C assembly protein HVY75_RS19140 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVY75_RS19165 ENOG4105QP9 Protein of unknown function (DUF2799) HVY75_RS19170 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY75_RS19175 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVY75_RS19180 ENOG4105CQC Prephenate dehydratase HVY75_RS19190 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVY75_RS19195 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVY75_RS19200 ENOG4105C34 Pseudouridine synthase HVY75_RS19205 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVY75_RS19210 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY75_RS19235 ENOG4105CSH Transporter HVY75_RS19240 ENOG4105T42 (LipO)protein HVY75_RS19245 ENOG4105JIM Phosphatidylserine synthase HVY75_RS19250 ENOG4105CD5 CoA-binding domain protein HVY75_RS19255 ENOG4106IUH DTW domain containing protein HVY75_RS19260 ENOG4105K63 Thioredoxin HVY75_RS19265 ENOG4105EIB trna rrna methyltransferase HVY75_RS19290 ENOG4105C1J atp-dependent rna helicase HVY75_RS19300 ENOG4108IYU L-aspartate oxidase HVY75_RS19310 ENOG4105EMN RNA polymerase sigma factor HVY75_RS19315 ENOG41069PW sigma-e factor negative regulatory protein HVY75_RS19320 ENOG4105VQK sigma E regulatory protein, MucB RseB HVY75_RS19325 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVY75_RS19335 ENOG4105C3F Signal peptidase i HVY75_RS19355 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVY75_RS19370 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVY75_RS19375 ENOG4106G6Q Transcriptional regulator HVY75_RS19380 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVY75_RS19385 ENOG4108Z6B deaminase HVY75_RS19395 ENOG4108ETH Formylglycinamide ribotide synthetase HVY75_RS19400 ENOG4107WP9 Histidine kinase HVY75_RS19405 ENOG4108SKK alpha helix protein HVY75_RS19410 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY75_RS19435 ENOG4107RE1 Inosine-guanosine kinase HVY75_RS19440 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVY75_RS19445 ENOG4105EU0 Major facilitator Superfamily HVY75_RS19450 ENOG4105CGH 5'-nucleotidase HVY75_RS19465 ENOG4108Z66 YbaK ebsC protein HVY75_RS19470 ENOG4105MBR gumn family HVY75_RS19475 ENOG41080ET plasmid maintenance system killer protein HVY75_RS19480 ENOG41081XE plasmid maintenance system antidote protein, xre family HVY75_RS19485 ENOG4105C59 p-type ATPase HVY75_RS19490 ENOG4107RY6 amino acid HVY75_RS19515 ENOG4107QZV Type I secretion membrane fusion protein HVY75_RS19520 ENOG4108Z6Z Transcriptional regulator HVY75_RS19525 ENOG4105G5H Membrane HVY75_RS19530 ENOG4107QX8 SPFH domain, Band 7 family protein HVY75_RS19535 ENOG41083J0 (ABC) transporter HVY75_RS19540 ENOG4105C4B ABC transporter, permease HVY75_RS19545 ENOG4107QR8 Thioredoxin HVY75_RS19550 ENOG4105E1F short-chain dehydrogenase reductase HVY75_RS19555 ENOG4108UJV acyl-CoA thioesterase i HVY75_RS19560 ENOG4108I0Y (ABC) transporter HVY75_RS19565 ENOG4105CV6 ABC transporter, permease HVY75_RS19570 ENOG4105GMB type VI secretion system effector, hcp1 family HVY75_RS19595 ENOG4107653 Transcriptional regulator HVY75_RS19605 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVY75_RS19610 ENOG41060W2 glyoxylate carboligase HVY75_RS19615 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVY75_RS19620 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY75_RS19625 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVY75_RS19635 ENOG4105DTE Xanthine uracil vitamin C permease HVY75_RS19640 ENOG4105BZW Glycerate kinase HVY75_RS19645 ENOG4105S0E allantoin catabolism protein HVY75_RS19650 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVY75_RS19655 ENOG4105DG4 malate L-lactate dehydrogenase HVY75_RS19660 ENOG4107R1Q Membrane protein FdrA HVY75_RS19665 ENOG4107REC cytoplasmic protein HVY75_RS19670 ENOG4105G5A Protein of unknown function (DUF2877) HVY75_RS19675 ENOG4105C5B carbamate kinase HVY75_RS19680 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVY75_RS19685 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVY75_RS19700 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY75_RS19710 ENOG4105S2T inner membrane protein YbcI HVY75_RS19715 ENOG4105WQ3 Rna-binding protein HVY75_RS19745 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY75_RS19755 ENOG4108SB3 DoxX Family HVY75_RS19760 ENOG4105D8G Major Facilitator superfamily HVY75_RS19765 ENOG4108MN2 Stationary phase inducible protein CsiE HVY75_RS19770 ENOG4107XM9 (LipO)protein HVY75_RS19775 ENOG4105ECY inositol monophosphatase HVY75_RS19795 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVY75_RS19815 ENOG4108ZIT Ferredoxin, 2FE-2S HVY75_RS19820 ENOG4105WVQ Fe-S assembly protein IscX HVY75_RS19830 ENOG4105YYA enhanced serine sensitivity protein SseB HVY75_RS19835 ENOG4105KHC sulfurtransferase HVY75_RS19840 ENOG4105DN3 alpha-2-macroglobulin domain protein HVY75_RS19845 ENOG4108JQB penicillin-binding protein 1C HVY75_RS19875 ENOG4105N21 Membrane HVY75_RS19890 ENOG4105VPD cellular component movement HVY75_RS19915 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVY75_RS19955 ENOG41076J9 exonuclease VIII HVY75_RS20035 ENOG4108TFU terminase (Small subunit) HVY75_RS20155 ENOG4105NVB glycoside hydrolase, family 19 HVY75_RS20170 ENOG41066DY Membrane HVY75_RS20175 ENOG4108ZMA Outer membrane lipoprotein HVY75_RS20180 ENOG41062G3 Protein of unknown function (DUF2633) HVY75_RS20185 ENOG4105BZU Histidine kinase HVY75_RS20190 ENOG4105C9X ppx gppa phosphatase HVY75_RS20195 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVY75_RS20200 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVY75_RS20215 ENOG4105C2W permease HVY75_RS20220 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVY75_RS20225 ENOG4105K89 arsenate reductase HVY75_RS20230 ENOG4105ERG peptidase m48, ste24p HVY75_RS20235 ENOG4105C02 permease HVY75_RS20240 ENOG4108JUA Transcriptional regulator HVY75_RS20245 ENOG4105I6X formate hydrogenlyase maturation HVY75_RS20250 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY75_RS20260 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY75_RS20265 ENOG4108JPZ Monovalent cation H antiporter subunit D HVY75_RS20270 ENOG4107WQX hydrogenase 4 membrane subunit HVY75_RS20275 ENOG4105D65 subunit l HVY75_RS20280 ENOG4107TDF Formate hydrogenlyase subunit 4 HVY75_RS20285 ENOG4108JPZ Monovalent cation H antiporter subunit D HVY75_RS20290 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY75_RS20295 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVY75_RS20300 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVY75_RS20310 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY75_RS20325 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVY75_RS20330 ENOG4105CGZ zinc metallopeptidase HVY75_RS20340 ENOG4106KED esterase YpfH HVY75_RS20355 ENOG4105KUZ arsenate reductase HVY75_RS20365 ENOG4105BZS acriflavin resistance protein HVY75_RS20370 ENOG4105BZU Histidine kinase HVY75_RS20375 ENOG4105BZ8 glutamate synthase HVY75_RS20385 ENOG4108PVD exported protein HVY75_RS20390 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY75_RS20395 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY75_RS20400 ENOG4105C6K Malic enzyme HVY75_RS20405 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVY75_RS20410 ENOG4106S4J ethanolamine utilization protein EutP HVY75_RS20415 ENOG4105NDK ethanolamine utilization protein HVY75_RS20420 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVY75_RS20425 ENOG4107WUY phosphate acetyltransferase HVY75_RS20430 ENOG4105KNY Microcompartments protein HVY75_RS20435 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVY75_RS20440 ENOG4108EKI Dehydrogenase HVY75_RS20445 ENOG4107RWI ethanolamine utilization protein eutJ HVY75_RS20450 ENOG4105C0A alcohol dehydrogenase HVY75_RS20455 ENOG4105ENY Ethanolamine utilization protein eutH HVY75_RS20460 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVY75_RS20465 ENOG4105CPD ethanolamine ammonia-lyase HVY75_RS20475 ENOG4106D67 ethanolamine utilization protein HVY75_RS20480 ENOG4108X49 Ethanolamine utilization protein EutK HVY75_RS20485 ENOG4108K3Z AraC family transcriptional regulator HVY75_RS20505 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVY75_RS20515 ENOG4105QZU Inner membrane protein YfeZ HVY75_RS20520 ENOG4105E7K (LipO)protein HVY75_RS20525 ENOG4105EZR dyp-type peroxidase family protein HVY75_RS20530 ENOG4107S1E Beta-lactamase HVY75_RS20535 ENOG4105C5Y PTS System HVY75_RS20550 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVY75_RS20555 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVY75_RS20560 ENOG4108I5D sulfate abc transporter HVY75_RS20565 ENOG4105ECW sulfate abc transporter HVY75_RS20570 ENOG4108IJ6 ABC transporter HVY75_RS20575 ENOG4105C6T cysteine synthase HVY75_RS20580 ENOG4105M0Y HVY75_RS20590 ENOG4105C5Y PTS System HVY75_RS20595 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY75_RS20605 ENOG4105C6T cysteine synthase HVY75_RS20615 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HVY75_RS20625 ENOG4105VRT cytoplasmic protein HVY75_RS20630 ENOG4105DHU Bile acid HVY75_RS20635 ENOG4108NFH Sugar hydrolase HVY75_RS20640 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVY75_RS20645 ENOG4105EAA nucleoside HVY75_RS20655 ENOG4105CN8 Transcriptional regulator HVY75_RS20680 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HVY75_RS20685 ENOG4105GXM Putative transcription regulator (DUF1323) HVY75_RS20690 ENOG4105HZG regulatoR HVY75_RS20705 ENOG4108KMM Diguanylate cyclase HVY75_RS20710 ENOG4105D9N nucleoside HVY75_RS20720 ENOG4109076 Conserved Protein HVY75_RS20735 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVY75_RS20740 ENOG410863U PTS System HVY75_RS20745 ENOG4105DC7 peptidase M24 HVY75_RS20750 ENOG4105CN9 Peptidase m42 family protein HVY75_RS20755 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY75_RS20760 ENOG4108CIP transcriptional regulator HVY75_RS20765 ENOG4105DY9 regulatoR HVY75_RS20770 ENOG4108HRK Histidine kinase HVY75_RS20775 ENOG4105CHM Aminotransferase HVY75_RS20785 ENOG4105D1S lipid A biosynthesis HVY75_RS20790 ENOG4105W9M Membrane HVY75_RS20805 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HVY75_RS20825 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HVY75_RS20835 ENOG4105CHR reductase HVY75_RS20845 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HVY75_RS20855 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HVY75_RS20920 ENOG4105S64 Formate nitrite transporter HVY75_RS20925 ENOG410903C (LipO)protein HVY75_RS20930 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVY75_RS20935 ENOG4105KZW UPF0381 protein HVY75_RS20950 ENOG4108BY2 phosphohistidine phosphatase HVY75_RS20960 ENOG4106PG1 outer membrane usher protein HVY75_RS20965 ENOG4108FZ9 Chaperone HVY75_RS20970 ENOG4105NEV Fimbrial HVY75_RS20975 ENOG4105UGQ Fimbrial HVY75_RS20980 ENOG4105US4 fimbrial-like protein yfcP HVY75_RS21000 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HVY75_RS21010 ENOG4105EJ9 Membrane HVY75_RS21015 ENOG4108BPE -transporting atpase HVY75_RS21020 ENOG4105MH2 YfcL protein HVY75_RS21025 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVY75_RS21030 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY75_RS21035 ENOG4105F9N Major Facilitator Superfamily HVY75_RS21040 ENOG4106WZ1 flagella biosynthesis regulator HVY75_RS21050 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY75_RS21060 ENOG4105DQR SNARE associated Golgi HVY75_RS21070 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVY75_RS21075 ENOG4108S3P Sporulation domain protein HVY75_RS21080 ENOG4105E96 Colicin v production protein HVY75_RS21085 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVY75_RS21090 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY75_RS21095 ENOG4105E89 ABC transporter HVY75_RS21100 ENOG4105E89 ABC transporter HVY75_RS21105 ENOG4105DSP amino acid AbC transporter HVY75_RS21110 ENOG4106YG3 ABC transporter HVY75_RS21115 ENOG4108JEH abc transporter atp-binding protein HVY75_RS21120 ENOG4105DNE Transposase HVY75_RS21125 ENOG4105ECP epimerase HVY75_RS21130 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVY75_RS21135 ENOG4105CYM Glutathione S-transferase HVY75_RS21140 ENOG4108SHQ Glutathione S-transferase HVY75_RS21145 ENOG4108RE9 Phosphodiesterase HVY75_RS21150 ENOG4105PTV Nudix Hydrolase HVY75_RS21155 ENOG4105K2J Transcriptional regulator HVY75_RS21170 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY75_RS21175 ENOG4108HHA Transketolase HVY75_RS21180 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVY75_RS21185 ENOG4105C6K Malic enzyme HVY75_RS21190 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVY75_RS21200 ENOG4105XWI UPF0304 protein HVY75_RS21205 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVY75_RS21210 ENOG4107QWE )-transporter HVY75_RS21215 ENOG4105DK2 UPF0207 protein HVY75_RS21220 ENOG4105CHM Aminotransferase HVY75_RS21225 ENOG4107NQ8 LysR family Transcriptional regulator HVY75_RS21240 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY75_RS21245 ENOG4105GKE subunit e HVY75_RS21250 ENOG4107QIZ NADH dehydrogenase HVY75_RS21255 ENOG4108IEH NADH dehydrogenase subunit g HVY75_RS21270 ENOG4107UFS subunit j HVY75_RS21280 ENOG4105D65 subunit l HVY75_RS21285 ENOG4105C8S subunit m HVY75_RS21295 ENOG4105ZD8 HVY75_RS21305 ENOG4105GDX Domain of unknown function (DUF1877) HVY75_RS21310 ENOG4105CP2 von willebrand factor, type a HVY75_RS21325 ENOG4107YB6 acetyltransferase, (GNAT) family HVY75_RS21330 ENOG4105TNS Conserved Protein HVY75_RS21335 ENOG4105E4F Isochorismate synthase HVY75_RS21350 ENOG4108IPT Naphthoate synthase HVY75_RS21360 ENOG4105CEY Amp-dependent synthetase and ligase HVY75_RS21365 ENOG4106GZG polymyxin resistance protein B HVY75_RS21415 ENOG4108UII YfaZ family HVY75_RS21420 ENOG4108EWA cinA-like protein HVY75_RS21435 ENOG4105DNE Transposase HVY75_RS21440 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY75_RS21450 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVY75_RS21455 ENOG4105CXY transporter HVY75_RS21460 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVY75_RS21465 ENOG4105FQR PH-inducible protein involved in stress response HVY75_RS21470 ENOG4105XPH Ferredoxin HVY75_RS21475 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY75_RS21480 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY75_RS21485 ENOG4107GHC outer membrane autotransporter HVY75_RS21495 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY75_RS21500 ENOG4105CHU acetyl-coa acetyltransferase HVY75_RS21505 ENOG4105CRW Short chain fatty acid transporter HVY75_RS21510 ENOG4107QNJ CoA-transferase subunit B HVY75_RS21515 ENOG4107QP7 CoA-transferase subunit A HVY75_RS21520 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY75_RS21525 ENOG4105BZU Histidine kinase HVY75_RS21530 ENOG4105BZU Histidine kinase HVY75_RS21535 ENOG41068CG regulatoR HVY75_RS21540 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVY75_RS21545 ENOG4105FCK Membrane HVY75_RS21550 ENOG4105CJ2 (LipO)protein HVY75_RS21555 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY75_RS21560 ENOG4105CF1 Alkylated DNA repair protein HVY75_RS21565 ENOG4105IBP Cyclic peptide transporter HVY75_RS21575 ENOG4105CDA abc transporter atp-binding protein HVY75_RS21580 ENOG4105E5Q amino acid AbC transporter HVY75_RS21585 ENOG4107R0W ABC transporter HVY75_RS21595 ENOG4107AQZ Membrane HVY75_RS21600 ENOG4108T1M outer membrane protein x HVY75_RS21605 ENOG4108I6E Sulfatase HVY75_RS21615 ENOG4105KST dependent repressor HVY75_RS21620 ENOG4105F4P )-transporter HVY75_RS21625 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY75_RS21630 ENOG4105C5H ABC transporter HVY75_RS21635 ENOG4108HCJ Hydrolase HVY75_RS21645 ENOG4105F1A Pyruvate formate-lyase HVY75_RS21650 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY75_RS21655 ENOG4105D06 uba thif-type nad fad binding protein HVY75_RS21660 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVY75_RS21665 ENOG4108JQ6 ABC transporter HVY75_RS21670 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY75_RS21675 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY75_RS21685 ENOG4105BZU Histidine kinase HVY75_RS21690 ENOG41064RH membrane protein YliF HVY75_RS21700 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVY75_RS21705 ENOG4105D8V Glucose sorbosone dehydrogenase HVY75_RS21710 ENOG4108TGY Glutathione S-transferase HVY75_RS21715 ENOG4105DZ1 carboxypeptidase HVY75_RS21720 ENOG4107FB0 transcriptional regulator DeoR family HVY75_RS21725 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVY75_RS21730 ENOG4107QF7 multi-drug HVY75_RS21740 ENOG4108HCJ Hydrolase HVY75_RS21745 ENOG4106UW1 Major Facilitator superfamily HVY75_RS21750 ENOG4108RFG Tetr family transcriptional regulator HVY75_RS21765 ENOG4105GWF inner membrane protein YbjM HVY75_RS21770 ENOG4108DBC nitroreductase HVY75_RS21780 ENOG4108RMJ sensory transduction regulator HVY75_RS21785 ENOG4107RUE extracellular solute-binding protein family 1 HVY75_RS21790 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY75_RS21795 ENOG4105F38 ABC transporter, permease HVY75_RS21800 ENOG4105D38 putrescine abc transporter HVY75_RS21805 ENOG4105RBQ inner membrane protein ybjO HVY75_RS21815 ENOG4106TNF Periplasmic binding protein HVY75_RS21820 ENOG4105DMR ABC, transporter HVY75_RS21825 ENOG4105GBT ABC transporter HVY75_RS21830 ENOG4106PMH Extracellular solute-binding protein family 3 HVY75_RS21835 ENOG4105E5Z arginine transporter ATP-binding subunit HVY75_RS21840 ENOG41064MM (LipO)protein HVY75_RS21850 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY75_RS21855 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY75_RS21860 ENOG4105CGD Nad-dependent epimerase dehydratase HVY75_RS21865 ENOG4105C5W Aldolase HVY75_RS21870 ENOG4105C7K acetolactate synthase HVY75_RS21880 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY75_RS21890 ENOG4105DWU Membrane HVY75_RS21895 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY75_RS21900 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVY75_RS21905 ENOG4108MJ5 VirK protein HVY75_RS21910 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVY75_RS21920 ENOG4105VEQ Cold shock protein HVY75_RS21930 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY75_RS21940 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVY75_RS21950 ENOG4108JJ8 (ABC) transporter HVY75_RS21955 ENOG4108JJ9 ABC, transporter HVY75_RS21960 ENOG4105C3M thioredoxin reductase HVY75_RS21970 ENOG4105CNU cell division protein FtsK HVY75_RS21980 ENOG4105D1H recombination factor protein RarA HVY75_RS21990 ENOG4105CHJ isochorismatase hydrolase HVY75_RS22000 ENOG4105E5D amino acid HVY75_RS22010 ENOG4105F1A Pyruvate formate-lyase HVY75_RS22015 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY75_RS22055 ENOG4106JVB Replication Protein HVY75_RS22195 ENOG4105C4R Atp-dependent dna helicase HVY75_RS22340 ENOG4108M24 von Willebrand factor, type A HVY75_RS22345 ENOG4108M24 von Willebrand factor, type A HVY75_RS22375 ENOG4105DAX Pfam:DUF2983 HVY75_RS22455 ENOG4105CAF HipA N-terminal domain protein HVY75_RS22475 ENOG4108R0M Aminoglycoside HVY75_RS22490 ENOG4105D6U Sodium Glutamate Symporter HVY75_RS22505 ENOG4108ZHR arsR family transcriptional regulator HVY75_RS22550 ENOG4108BUD transposase HVY75_RS22575 ENOG4108BUD transposase HVY75_RS22595 ENOG4108BUD transposase HVY75_RS22620 ENOG4108BUD transposase HVY75_RS22635 ENOG4108BUD transposase HVY75_RS22650 ENOG4105EMU Dehydrogenase HVY75_RS22655 ENOG4108BUD transposase HVY75_RS22700 ENOG4108BUD transposase HVY75_RS22770 ENOG410624V efflux system protein HVY75_RS22800 ENOG4105DR5 peptidase HVY75_RS22810 ENOG4105E3B Multicopper oxidase HVY75_RS22815 ENOG4105VR0 copper resistance HVY75_RS22820 ENOG4105JDN Copper resistance protein HVY75_RS22825 ENOG4108PG2 copper resistance HVY75_RS22830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY75_RS22835 ENOG4105GR3 Histidine kinase HVY75_RS22920 ENOG4108KTG Membrane protein, drug metabolite transporter HVY75_RS23000 ENOG4108BUD transposase HVY75_RS23030 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HVY75_RS23050 ENOG4105T95 Thiol disulfide interChange protein HVY75_RS23210 ENOG4108SER Transposase HVY75_RS23215 ENOG41074AV Hok/gef family HVY75_RS23380 ENOG4108BUD transposase HVY75_RS23390 ENOG4105K4U addiction module toxin, RelE StbE family HVY75_RS23400 ENOG410607W Transposase HVY75_RS23425 ENOG4108BUD transposase HVY75_RS23445 ENOG4106JVB Replication Protein HVY75_RS23485 ENOG4105DFE Dna adenine methylase