locus-tag	class	description
HVY75_RS00025	COG4695	Portal protein
HVY75_RS00115	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY75_RS00120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY75_RS00175	COG1882	Formate acetyltransferase
HVY75_RS00180	COG2116	formate transmembrane transporter activity
HVY75_RS00185	COG1944	ATP diphosphatase activity
HVY75_RS00190	COG2323	membrane
HVY75_RS00210	COG0539	negative regulation of cytoplasmic translation
HVY75_RS00220	COG2333	competence protein COMEC
HVY75_RS00220	COG0658	competence protein
HVY75_RS00235	COG3214	Protein conserved in bacteria
HVY75_RS00250	COG3173	Aminoglycoside phosphotransferase
HVY75_RS00255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY75_RS00260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVY75_RS00270	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVY75_RS00280	COG2989	Protein conserved in bacteria
HVY75_RS00285	COG3108	Peptidase M15
HVY75_RS00290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVY75_RS00295	COG1448	Aminotransferase
HVY75_RS00300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY75_RS00315	COG0308	aminopeptidase N
HVY75_RS00320	COG1116	anion transmembrane transporter activity
HVY75_RS00325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY75_RS00335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY75_RS00340	COG0431	NADPH-dependent FMN reductase
HVY75_RS00355	COG0633	Ferredoxin
HVY75_RS00355	COG3217	Mosc domain protein beta barrel domain protein
HVY75_RS00365	COG0488	(ABC) transporter
HVY75_RS00370	COG2995	paraquat-inducible protein a
HVY75_RS00375	COG3008	intermembrane lipid transfer
HVY75_RS00375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY75_RS00380	COG3009	Protein conserved in bacteria
HVY75_RS00385	COG3130	regulation of translation
HVY75_RS00395	COG1067	ATP-dependent peptidase activity
HVY75_RS00415	COG3070	regulator of competence-specific genes
HVY75_RS00420	COG1289	transmembrane transporter activity
HVY75_RS00425	COG3304	Inner membrane component domain
HVY75_RS00430	COG0210	DNA helicase
HVY75_RS00445	COG1832	CoA-binding protein
HVY75_RS00460	COG1254	Belongs to the acylphosphatase family
HVY75_RS00465	COG2920	part of a sulfur-relay system
HVY75_RS00470	COG0670	Belongs to the BI1 family
HVY75_RS00485	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY75_RS00490	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY75_RS00495	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVY75_RS00500	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY75_RS00505	COG1999	signal sequence binding
HVY75_RS00510	COG1773	rubredoxin
HVY75_RS00515	COG3318	Belongs to the UPF0149 family
HVY75_RS00515	COG3012	SEC-C Motif Domain Protein
HVY75_RS00520	COG0814	amino acid
HVY75_RS00530	COG1528	Iron-storage protein
HVY75_RS00540	COG1528	Iron-storage protein
HVY75_RS00545	COG1879	ABC-type sugar transport system periplasmic component
HVY75_RS00550	COG1129	ABC transporter
HVY75_RS00555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY75_RS00560	COG1877	trehalose-phosphatase activity
HVY75_RS00570	COG0589	response to stress
HVY75_RS00585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVY75_RS00595	COG0643	Histidine kinase
HVY75_RS00595	COG2198	Histidine kinase
HVY75_RS00600	COG0835	chemotaxis
HVY75_RS00630	COG0840	transmembrane signaling receptor activity
HVY75_RS00645	COG0745	RESPONSE REGULATOR receiver
HVY75_RS00675	COG0583	DNA-binding transcription factor activity
HVY75_RS00700	COG3729	General stress protein
HVY75_RS00705	COG1309	transcriptional regulator
HVY75_RS00710	COG2200	EAL domain
HVY75_RS00715	COG2199	diguanylate cyclase activity
HVY75_RS00725	COG1215	transferase activity, transferring glycosyl groups
HVY75_RS00730	COG0425	Belongs to the sulfur carrier protein TusA family
HVY75_RS00735	COG2391	methyltransferase activity
HVY75_RS00745	COG0366	Alpha amylase catalytic
HVY75_RS00800	COG2197	response regulator
HVY75_RS00810	COG2197	response regulator
HVY75_RS00840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY75_RS00845	COG1271	oxidase subunit
HVY75_RS00850	COG1294	oxidase, subunit
HVY75_RS00865	COG2205	protein histidine kinase activity
HVY75_RS00865	COG2198	Histidine kinase
HVY75_RS00865	COG0784	Response regulator, receiver
HVY75_RS00870	COG1879	ABC-type sugar transport system periplasmic component
HVY75_RS00875	COG0745	RESPONSE REGULATOR receiver
HVY75_RS00880	COG3005	denitrification pathway
HVY75_RS00885	COG0243	molybdopterin cofactor binding
HVY75_RS00900	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVY75_RS00915	COG3102	Protein conserved in bacteria
HVY75_RS00935	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVY75_RS00940	COG1801	Protein of unknown function DUF72
HVY75_RS00945	COG1335	isochorismatase
HVY75_RS00955	COG0494	nUDIX hydrolase
HVY75_RS00960	COG0217	transcriptional regulatory protein
HVY75_RS00990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY75_RS01000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVY75_RS01005	COG0739	heme binding
HVY75_RS01010	COG1560	Kdo2-lipid A biosynthetic process
HVY75_RS01015	COG0469	pyruvate kinase activity
HVY75_RS01020	COG1737	Transcriptional regulator
HVY75_RS01025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVY75_RS01030	COG0129	dihydroxy-acid dehydratase activity
HVY75_RS01035	COG0800	Aldolase
HVY75_RS01045	COG3141	response to X-ray
HVY75_RS01055	COG2979	Protein of unknown function (DUF533)
HVY75_RS01060	COG1770	oligopeptidase
HVY75_RS01065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY75_RS01070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY75_RS01080	COG2372	response to copper ion
HVY75_RS01085	COG1276	copper resistance
HVY75_RS01095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY75_RS01115	COG3008	intermembrane lipid transfer
HVY75_RS01120	COG2995	paraquat-inducible protein a
HVY75_RS01125	COG1956	GAF domain-containing protein
HVY75_RS01145	COG2814	Major facilitator Superfamily
HVY75_RS01150	COG1414	Transcriptional regulator
HVY75_RS01180	COG2226	methyltransferase
HVY75_RS01195	COG3716	PTS system mannose fructose sorbose family IID component
HVY75_RS01200	COG3715	PTS system
HVY75_RS01205	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS01205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY75_RS01210	COG1253	flavin adenine dinucleotide binding
HVY75_RS01215	COG2200	EAL domain
HVY75_RS01220	COG1760	l-serine dehydratase
HVY75_RS01230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY75_RS01250	COG0251	oxidation-reduction process
HVY75_RS01265	COG1199	ATP-dependent helicase activity
HVY75_RS01270	COG1214	PFAM Peptidase M22, glycoprotease
HVY75_RS01275	COG3065	identical protein binding
HVY75_RS01280	COG0318	PFAM AMP-dependent synthetase and ligase
HVY75_RS01285	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVY75_RS01290	COG1388	LysM domain
HVY75_RS01290	COG1376	ErfK ybiS ycfS ynhG family protein
HVY75_RS01295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVY75_RS01300	COG4763	Acyl-transferase
HVY75_RS01305	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY75_RS01315	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY75_RS01325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVY75_RS01330	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY75_RS01340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY75_RS01345	COG1177	transmembrane transport
HVY75_RS01380	COG3139	Protein of unknown function (DUF1315)
HVY75_RS01385	COG1335	isochorismatase
HVY75_RS01390	COG0252	asparaginase activity
HVY75_RS01400	COG0616	signal peptide processing
HVY75_RS01405	COG0778	Nitroreductase
HVY75_RS01415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY75_RS01420	COG0443	Heat shock 70 kDa protein
HVY75_RS01440	COG0494	nUDIX hydrolase
HVY75_RS01445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY75_RS01450	COG2897	thiosulfate sulfurtransferase activity
HVY75_RS01455	COG4136	ATPase activity
HVY75_RS01460	COG4135	transport system, permease component
HVY75_RS01465	COG4134	Bacterial extracellular solute-binding protein
HVY75_RS01470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY75_RS01475	COG0398	Pfam SNARE associated Golgi protein
HVY75_RS01480	COG0398	Pfam SNARE associated Golgi protein
HVY75_RS01485	COG0708	Exodeoxyribonuclease III
HVY75_RS01515	COG3678	ATP-independent chaperone mediated protein folding
HVY75_RS01525	COG0322	excinuclease ABC activity
HVY75_RS01535	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY75_RS01540	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY75_RS01545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY75_RS01550	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY75_RS01555	COG1917	Cupin 2, conserved barrel domain protein
HVY75_RS01555	COG2169	Transcriptional regulator
HVY75_RS01560	COG1486	melibiose metabolic process
HVY75_RS01570	COG0753	catalase activity
HVY75_RS01585	COG1988	membrane-bound metal-dependent
HVY75_RS01590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY75_RS01600	COG3001	Fructosamine kinase
HVY75_RS01610	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY75_RS01615	COG3137	Salt-induced outer membrane protein
HVY75_RS01675	COG0791	NLP P60 protein
HVY75_RS01690	COG4256	Hemin uptake protein
HVY75_RS01695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY75_RS01705	COG0574	Belongs to the PEP-utilizing enzyme family
HVY75_RS01705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY75_RS01720	COG0628	permease
HVY75_RS01725	COG0247	lactate metabolic process
HVY75_RS01725	COG0277	FAD linked oxidase domain protein
HVY75_RS01730	COG2050	protein possibly involved in aromatic compounds catabolism
HVY75_RS01740	COG0316	Belongs to the HesB IscA family
HVY75_RS01745	COG0719	Fe-S assembly protein
HVY75_RS01750	COG0396	ATPase activity
HVY75_RS01755	COG0719	Fe-S assembly protein
HVY75_RS01770	COG1376	ErfK ybiS ycfS ynhG family protein
HVY75_RS01775	COG4238	major outer membrane lipoprotein
HVY75_RS01780	COG0469	pyruvate kinase activity
HVY75_RS01795	COG4529	Protein conserved in bacteria
HVY75_RS01820	COG0307	riboflavin synthase, alpha
HVY75_RS01825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY75_RS01830	COG2814	Major facilitator Superfamily
HVY75_RS01835	COG0583	DNA-binding transcription factor activity
HVY75_RS01850	COG2814	Major facilitator Superfamily
HVY75_RS01855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY75_RS01860	COG0791	NLP P60 protein
HVY75_RS01865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVY75_RS01870	COG1201	RNA secondary structure unwinding
HVY75_RS01880	COG0346	lactoylglutathione lyase activity
HVY75_RS01885	COG1902	pentaerythritol trinitrate reductase activity
HVY75_RS01890	COG1309	transcriptional regulator
HVY75_RS01895	COG3313	Fe-S protein
HVY75_RS01900	COG4989	oxidoreductase activity
HVY75_RS01905	COG2032	superoxide dismutase activity
HVY75_RS01910	COG1289	transmembrane transporter activity
HVY75_RS01915	COG1566	PFAM secretion protein HlyD family protein
HVY75_RS01930	COG3133	Outer membrane lipoprotein
HVY75_RS01940	COG3895	Periplasmic Protein
HVY75_RS01960	COG0625	glutathione transferase activity
HVY75_RS01965	COG3104	oligopeptide transport
HVY75_RS01970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVY75_RS01980	COG4659	FMN binding
HVY75_RS02020	COG0673	inositol 2-dehydrogenase activity
HVY75_RS02030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY75_RS02035	COG5339	Protein conserved in bacteria
HVY75_RS02040	COG1482	cell wall glycoprotein biosynthetic process
HVY75_RS02045	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY75_RS02045	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY75_RS02050	COG0114	fumarate hydratase activity
HVY75_RS02060	COG2205	protein histidine kinase activity
HVY75_RS02065	COG0745	RESPONSE REGULATOR receiver
HVY75_RS02070	COG3136	membrane protein required for alginate biosynthesis
HVY75_RS02080	COG0531	amino acid
HVY75_RS02090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVY75_RS02095	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVY75_RS02105	COG3591	Belongs to the peptidase S1B family
HVY75_RS02120	COG2814	Major facilitator Superfamily
HVY75_RS02125	COG0583	DNA-binding transcription factor activity
HVY75_RS02130	COG1940	carbohydrate kinase activity
HVY75_RS02135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY75_RS02170	COG3238	Protein conserved in bacteria
HVY75_RS02175	COG1247	-acetyltransferase
HVY75_RS02180	COG2130	NADP-dependent
HVY75_RS02185	COG1802	Transcriptional regulator
HVY75_RS02190	COG4772	TonB-dependent receptor
HVY75_RS02195	COG3391	amine dehydrogenase activity
HVY75_RS02200	COG1113	amino acid transport
HVY75_RS02205	COG0625	glutathione transferase activity
HVY75_RS02225	COG5433	transposase activity
HVY75_RS02290	COG0384	phenazine biosynthesis protein PhzF
HVY75_RS02300	COG1609	Transcriptional regulator
HVY75_RS02310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY75_RS02315	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVY75_RS02320	COG1414	Transcriptional regulator
HVY75_RS02325	COG4948	Mandelate Racemase Muconate Lactonizing
HVY75_RS02330	COG4829	muconolactone delta-isomerase
HVY75_RS02335	COG3485	protocatechuate 3,4-dioxygenase
HVY75_RS02370	COG0697	spore germination
HVY75_RS02380	COG0437	4 iron, 4 sulfur cluster binding
HVY75_RS02385	COG2864	formate dehydrogenase
HVY75_RS02390	COG3093	addiction module antidote protein HigA
HVY75_RS02400	COG1064	alcohol dehydrogenase
HVY75_RS02420	COG1764	response to oxidative stress
HVY75_RS02430	COG0583	DNA-binding transcription factor activity
HVY75_RS02435	COG3485	protocatechuate 3,4-dioxygenase
HVY75_RS02440	COG3485	protocatechuate 3,4-dioxygenase
HVY75_RS02445	COG5383	Protein conserved in bacteria
HVY75_RS02455	COG2841	Protein conserved in bacteria
HVY75_RS02460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY75_RS02465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY75_RS02470	COG0500	methyltransferase
HVY75_RS02480	COG0826	peptidase U32
HVY75_RS02495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY75_RS02500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY75_RS02505	COG3842	ATPase activity
HVY75_RS02510	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY75_RS02515	COG1177	transmembrane transport
HVY75_RS02545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY75_RS02560	COG4948	Mandelate Racemase Muconate Lactonizing
HVY75_RS02565	COG1063	alcohol dehydrogenase
HVY75_RS02570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY75_RS02580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY75_RS02585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY75_RS02590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY75_RS02590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY75_RS02600	COG0246	Mannitol dehydrogenase
HVY75_RS02610	COG1802	Transcriptional regulator
HVY75_RS02615	COG4221	oxidoreductase activity
HVY75_RS02620	COG0339	signal peptide processing
HVY75_RS02625	COG1546	Belongs to the CinA family
HVY75_RS02630	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY75_RS02635	COG3706	GGDEF domain
HVY75_RS02640	COG2814	Major facilitator Superfamily
HVY75_RS02645	COG0697	spore germination
HVY75_RS02655	COG4977	sequence-specific DNA binding
HVY75_RS02660	COG1846	Transcriptional regulator
HVY75_RS02675	COG0583	DNA-binding transcription factor activity
HVY75_RS02680	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS02685	COG2066	Belongs to the glutaminase family
HVY75_RS02695	COG2199	diguanylate cyclase activity
HVY75_RS02705	COG3781	membrane
HVY75_RS02760	COG2207	Transcriptional regulator
HVY75_RS02780	COG4178	(ABC) transporter
HVY75_RS02785	COG4771	TonB-dependent receptor
HVY75_RS02790	COG0612	Peptidase, M16
HVY75_RS02795	COG0076	glutamate decarboxylase activity
HVY75_RS02800	COG0531	amino acid
HVY75_RS02810	COG3706	GGDEF domain
HVY75_RS02815	COG2202	Pas domain
HVY75_RS02815	COG2199	diguanylate cyclase activity
HVY75_RS02815	COG2200	EAL domain
HVY75_RS02830	COG3038	cytochrome b561
HVY75_RS02835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVY75_RS02840	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY75_RS02850	COG1643	Atp-dependent helicase
HVY75_RS02860	COG0671	phosphoesterase, PA-phosphatase related
HVY75_RS02860	COG2453	phosphatase
HVY75_RS02865	COG2267	carboxylic ester hydrolase activity
HVY75_RS02870	COG4589	Belongs to the CDS family
HVY75_RS02875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY75_RS02885	COG0667	Aldo Keto reductase
HVY75_RS02890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY75_RS02895	COG3327	negative regulation of DNA-templated transcription, initiation
HVY75_RS02900	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVY75_RS02905	COG0183	Belongs to the thiolase family
HVY75_RS02910	COG2050	protein possibly involved in aromatic compounds catabolism
HVY75_RS02915	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY75_RS02920	COG1024	Enoyl-CoA hydratase
HVY75_RS02925	COG1024	Enoyl-CoA hydratase
HVY75_RS02930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY75_RS02935	COG2151	metal-sulfur cluster biosynthetic enzyme
HVY75_RS02940	COG3396	Phenylacetate-CoA oxygenase
HVY75_RS02945	COG3460	Phenylacetate-CoA oxygenase
HVY75_RS02950	COG3396	Phenylacetate-CoA oxygenase
HVY75_RS02955	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS02955	COG2030	dehydratase
HVY75_RS02960	COG3733	amine oxidase
HVY75_RS02965	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS02980	COG3784	Protein of unknown function (DUF1318)
HVY75_RS02990	COG2911	Protein conserved in bacteria
HVY75_RS02995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVY75_RS03000	COG3187	Heat shock protein
HVY75_RS03005	COG3042	response to heat
HVY75_RS03015	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVY75_RS03015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVY75_RS03015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY75_RS03015	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVY75_RS03020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY75_RS03025	COG0589	response to stress
HVY75_RS03035	COG0513	Belongs to the DEAD box helicase family
HVY75_RS03050	COG3706	GGDEF domain
HVY75_RS03055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY75_RS03060	COG0596	Alpha beta hydrolase
HVY75_RS03070	COG0183	Belongs to the thiolase family
HVY75_RS03075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY75_RS03085	COG1414	Transcriptional regulator
HVY75_RS03090	COG2840	Smr protein MutS2
HVY75_RS03095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY75_RS03100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY75_RS03105	COG0589	response to stress
HVY75_RS03110	COG3182	Iron-regulated membrane protein
HVY75_RS03115	COG0668	transmembrane transport
HVY75_RS03120	COG4166	transmembrane transport
HVY75_RS03125	COG2866	Carboxypeptidase
HVY75_RS03130	COG4948	Mandelate Racemase Muconate Lactonizing
HVY75_RS03135	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVY75_RS03140	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVY75_RS03150	COG3106	COG3106 Predicted ATPase
HVY75_RS03155	COG1609	Transcriptional regulator
HVY75_RS03165	COG3842	ATPase activity
HVY75_RS03170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY75_RS03175	COG1554	hydrolase, family 65, central catalytic
HVY75_RS03180	COG0673	inositol 2-dehydrogenase activity
HVY75_RS03185	COG1082	Xylose isomerase domain protein TIM barrel
HVY75_RS03190	COG1063	alcohol dehydrogenase
HVY75_RS03195	COG0395	ABC-type sugar transport system, permease component
HVY75_RS03200	COG1175	transmembrane transport
HVY75_RS03205	COG1653	transport
HVY75_RS03210	COG0366	Alpha amylase catalytic
HVY75_RS03215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY75_RS03225	COG1983	PspC domain protein
HVY75_RS03235	COG1842	Phage shock protein A
HVY75_RS03240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY75_RS03245	COG4166	transmembrane transport
HVY75_RS03250	COG4168	peptide transport system, permease
HVY75_RS03255	COG4171	peptide transport system, permease
HVY75_RS03260	COG4172	Belongs to the ABC transporter superfamily
HVY75_RS03265	COG4172	Belongs to the ABC transporter superfamily
HVY75_RS03270	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVY75_RS03275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY75_RS03275	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY75_RS03285	COG5001	Diguanylate cyclase
HVY75_RS03295	COG1349	DNA-binding transcription factor activity
HVY75_RS03305	COG0023	Translation Initiation Factor
HVY75_RS03315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVY75_RS03320	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVY75_RS03325	COG0671	phosphoesterase, PA-phosphatase related
HVY75_RS03355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY75_RS03365	COG0616	signal peptide processing
HVY75_RS03370	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS03375	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVY75_RS03380	COG1187	pseudouridine synthase activity
HVY75_RS03385	COG4907	membrane protein (DUF2207)
HVY75_RS03390	COG0009	L-threonylcarbamoyladenylate synthase
HVY75_RS03395	COG0613	PHP domain protein
HVY75_RS03405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY75_RS03410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY75_RS03410	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY75_RS03415	COG0134	indole-3-glycerol-phosphate synthase activity
HVY75_RS03415	COG0135	phosphoribosylanthranilate isomerase activity
HVY75_RS03430	COG3047	cAMP biosynthetic process
HVY75_RS03435	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVY75_RS03450	COG1607	acyl-coa hydrolase
HVY75_RS03460	COG2350	Protein conserved in bacteria
HVY75_RS03485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY75_RS03490	COG4608	Belongs to the ABC transporter superfamily
HVY75_RS03495	COG0444	Belongs to the ABC transporter superfamily
HVY75_RS03515	COG2095	MarC family integral membrane protein
HVY75_RS03520	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS03520	COG1454	alcohol dehydrogenase
HVY75_RS03525	COG3385	transposase activity
HVY75_RS03530	COG1435	thymidine kinase activity
HVY75_RS03540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY75_RS03545	COG0745	RESPONSE REGULATOR receiver
HVY75_RS03550	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVY75_RS03560	COG0788	formyltetrahydrofolate deformylase activity
HVY75_RS03605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY75_RS03610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVY75_RS03615	COG2181	nitrate reductase activity
HVY75_RS03620	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY75_RS03625	COG1140	nitrate reductase beta subunit
HVY75_RS03630	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY75_RS03635	COG2223	nitrite transmembrane transporter activity
HVY75_RS03640	COG3850	Histidine kinase
HVY75_RS03645	COG2197	response regulator
HVY75_RS03650	COG4932	domain protein
HVY75_RS03655	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVY75_RS03660	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVY75_RS03665	COG4572	Cation transport regulator
HVY75_RS03670	COG0387	Pfam Sodium calcium exchanger
HVY75_RS03690	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY75_RS03715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVY75_RS03720	COG0659	secondary active sulfate transmembrane transporter activity
HVY75_RS03735	COG0012	GTP binding
HVY75_RS03800	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVY75_RS03810	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVY75_RS03820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY75_RS03830	COG2719	SpoVR family
HVY75_RS03845	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVY75_RS03850	COG1470	cell adhesion involved in biofilm formation
HVY75_RS03850	COG1388	LysM domain
HVY75_RS03860	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY75_RS03875	COG2894	cell division
HVY75_RS03885	COG1124	(ABC) transporter
HVY75_RS03895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY75_RS03900	COG0601	transmembrane transport
HVY75_RS03905	COG0747	negative chemotaxis
HVY75_RS03920	COG1473	amidohydrolase
HVY75_RS03930	COG0217	transcriptional regulatory protein
HVY75_RS03940	COG1388	LysM domain
HVY75_RS03940	COG4932	domain protein
HVY75_RS03940	COG2373	Large extracellular alpha-helical protein
HVY75_RS03960	COG0582	viral genome integration into host DNA
HVY75_RS03965	COG0538	isocitrate dehydrogenase activity
HVY75_RS03970	COG1187	pseudouridine synthase activity
HVY75_RS03990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVY75_RS03995	COG0745	RESPONSE REGULATOR receiver
HVY75_RS04000	COG2205	protein histidine kinase activity
HVY75_RS04005	COG2850	peptidyl-arginine hydroxylation
HVY75_RS04010	COG0656	L-ascorbic acid biosynthetic process
HVY75_RS04015	COG3713	MltA-interacting MipA family protein
HVY75_RS04020	COG2766	serine protein kinase
HVY75_RS04030	COG2199	diguanylate cyclase activity
HVY75_RS04035	COG2199	diguanylate cyclase activity
HVY75_RS04040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY75_RS04055	COG2807	transmembrane transport
HVY75_RS04060	COG3189	MarR family transcriptional regulator
HVY75_RS04065	COG3042	response to heat
HVY75_RS04070	COG2199	diguanylate cyclase activity
HVY75_RS04070	COG2203	Gaf domain
HVY75_RS04085	COG2261	transglycosylase associated protein
HVY75_RS04095	COG3134	Outer membrane lipoprotein
HVY75_RS04100	COG1252	NADH dehydrogenase
HVY75_RS04115	COG0510	thiamine kinase activity
HVY75_RS04120	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVY75_RS04125	COG5633	Lipoprotein
HVY75_RS04130	COG0537	adenosine 5'-monophosphoramidase activity
HVY75_RS04140	COG0084	hydrolase, TatD family'
HVY75_RS04145	COG0470	DNA polymerase III
HVY75_RS04155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVY75_RS04160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY75_RS04165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY75_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS04180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVY75_RS04200	COG1399	metal-binding, possibly nucleic acid-binding protein
HVY75_RS04205	COG0424	maF-like protein
HVY75_RS04210	COG0564	pseudouridine synthase activity
HVY75_RS04215	COG1530	ribonuclease E activity
HVY75_RS04220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVY75_RS04225	COG1256	bacterial-type flagellum assembly
HVY75_RS04230	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVY75_RS04230	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVY75_RS04250	COG4787	bacterial-type flagellum-dependent cell motility
HVY75_RS04255	COG1749	Flagellar hook protein flgE
HVY75_RS04260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVY75_RS04265	COG1558	bacterial-type flagellum-dependent cell motility
HVY75_RS04280	COG2747	anti-sigma28 factor FlgM
HVY75_RS04290	COG0728	peptidoglycan biosynthetic process
HVY75_RS04295	COG0673	inositol 2-dehydrogenase activity
HVY75_RS04305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY75_RS04340	COG3038	cytochrome b561
HVY75_RS04345	COG2353	YceI-like domain
HVY75_RS04355	COG1560	Kdo2-lipid A biosynthetic process
HVY75_RS04370	COG5645	(Lipo)protein
HVY75_RS04375	COG2943	transferase activity, transferring hexosyl groups
HVY75_RS04390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY75_RS04435	COG1462	curli production assembly transport component CsgG
HVY75_RS04445	COG3381	protein complex oligomerization
HVY75_RS04465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVY75_RS04470	COG3104	oligopeptide transport
HVY75_RS04475	COG1982	Orn Lys Arg decarboxylase major
HVY75_RS04480	COG0531	amino acid
HVY75_RS04485	COG3710	Transcriptional regulator
HVY75_RS04490	COG3706	GGDEF domain
HVY75_RS04495	COG0457	Tetratricopeptide repeat
HVY75_RS04500	COG0726	polysaccharide deacetylase
HVY75_RS04500	COG1649	PFAM Uncharacterised BCR, COG1649
HVY75_RS04505	COG1215	transferase activity, transferring glycosyl groups
HVY75_RS04510	COG3658	cytochrome
HVY75_RS04515	COG1702	phosphate starvation-inducible protein PhoH
HVY75_RS04525	COG2822	iron ion transport
HVY75_RS04535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY75_RS04545	COG0506	proline dehydrogenase activity
HVY75_RS04545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY75_RS04545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY75_RS04550	COG1560	Kdo2-lipid A biosynthetic process
HVY75_RS04555	COG2990	Protein conserved in bacteria
HVY75_RS04560	COG0438	transferase activity, transferring glycosyl groups
HVY75_RS04565	COG0726	polysaccharide deacetylase
HVY75_RS04570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVY75_RS04575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVY75_RS04585	COG1766	The M ring may be actively involved in energy transduction
HVY75_RS04590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY75_RS04595	COG1317	bacterial-type flagellum organization
HVY75_RS04600	COG1157	protein secretion by the type III secretion system
HVY75_RS04605	COG2882	bacterial-type flagellum organization
HVY75_RS04610	COG3144	bacterial-type flagellum assembly
HVY75_RS04615	COG1580	Controls the rotational direction of flagella during chemotaxis
HVY75_RS04620	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY75_RS04625	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY75_RS04630	COG3190	flagellar
HVY75_RS04635	COG1338	Plays a role in the flagellum-specific transport system
HVY75_RS04650	COG2197	response regulator
HVY75_RS04675	COG5475	Uncharacterized small protein (DUF2158)
HVY75_RS04680	COG2354	Protein conserved in bacteria
HVY75_RS04685	COG0697	spore germination
HVY75_RS04690	COG3727	T/G mismatch-specific endonuclease activity
HVY75_RS04695	COG1418	mRNA catabolic process
HVY75_RS04705	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY75_RS04715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY75_RS04740	COG0583	DNA-binding transcription factor activity
HVY75_RS04790	COG3157	Type VI secretion system effector, Hcp
HVY75_RS04870	COG3501	Rhs element vgr protein
HVY75_RS04910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVY75_RS04915	COG0477	Major facilitator Superfamily
HVY75_RS04925	COG0534	Mate efflux family protein
HVY75_RS04965	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS04965	COG1454	alcohol dehydrogenase
HVY75_RS04975	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS04975	COG1454	alcohol dehydrogenase
HVY75_RS04980	COG1882	Formate acetyltransferase
HVY75_RS04985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY75_RS04995	COG4869	propanediol catabolic process
HVY75_RS05015	COG1376	ErfK ybiS ycfS ynhG family protein
HVY75_RS05115	COG4656	Part of a membrane complex involved in electron transport
HVY75_RS05145	COG1289	transmembrane transporter activity
HVY75_RS05155	COG2925	Exonuclease
HVY75_RS05160	COG0425	Belongs to the sulfur carrier protein TusA family
HVY75_RS05165	COG2391	methyltransferase activity
HVY75_RS05170	COG0531	amino acid
HVY75_RS05180	COG0583	DNA-binding transcription factor activity
HVY75_RS05185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY75_RS05190	COG4115	mRNA cleavage
HVY75_RS05195	COG2161	toxin-antitoxin pair type II binding
HVY75_RS05210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVY75_RS05220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY75_RS05220	COG0131	Imidazoleglycerol-phosphate dehydratase
HVY75_RS05225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVY75_RS05255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVY75_RS05290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY75_RS05295	COG1091	dTDP-4-dehydrorhamnose reductase activity
HVY75_RS05300	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY75_RS05305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY75_RS05310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY75_RS05320	COG0438	transferase activity, transferring glycosyl groups
HVY75_RS05325	COG2327	Polysaccharide pyruvyl transferase
HVY75_RS05330	COG2244	polysaccharide biosynthetic process
HVY75_RS05335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVY75_RS05340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVY75_RS05345	COG0662	Cupin 2, conserved barrel domain protein
HVY75_RS05345	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVY75_RS05350	COG0297	glycogen (starch) synthase activity
HVY75_RS05355	COG1051	belongs to the nudix hydrolase family
HVY75_RS05360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY75_RS05365	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVY75_RS05370	COG0110	maltose O-acetyltransferase activity
HVY75_RS05375	COG1216	Glycosyl transferase, family 2
HVY75_RS05385	COG0438	transferase activity, transferring glycosyl groups
HVY75_RS05390	COG1045	serine acetyltransferase
HVY75_RS05395	COG0463	Glycosyl transferase, family 2
HVY75_RS05400	COG0489	protein tyrosine kinase activity
HVY75_RS05400	COG3206	protein involved in exopolysaccharide biosynthesis
HVY75_RS05405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVY75_RS05410	COG1596	polysaccharide export
HVY75_RS05415	COG1253	flavin adenine dinucleotide binding
HVY75_RS05430	COG2982	Protein involved in outer membrane biogenesis
HVY75_RS05445	COG3447	MASE1 domain protein
HVY75_RS05445	COG5001	Diguanylate cyclase
HVY75_RS05445	COG5002	protein histidine kinase activity
HVY75_RS05450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVY75_RS05455	COG0443	Heat shock 70 kDa protein
HVY75_RS05460	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVY75_RS05465	COG3779	Protein conserved in bacteria
HVY75_RS05470	COG0631	protein serine/threonine phosphatase activity
HVY75_RS05475	COG4245	von Willebrand factor, type A
HVY75_RS05515	COG2205	protein histidine kinase activity
HVY75_RS05520	COG0745	RESPONSE REGULATOR receiver
HVY75_RS05540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY75_RS05550	COG1070	Carbohydrate kinase
HVY75_RS05575	COG1069	ribulokinase activity
HVY75_RS05585	COG1830	Aldolase
HVY75_RS05590	COG2211	Major facilitator Superfamily
HVY75_RS05595	COG1397	ADP-ribosylglycohydrolase
HVY75_RS05600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY75_RS05605	COG2188	Transcriptional regulator
HVY75_RS05610	COG3757	hydrolase, family 25
HVY75_RS05615	COG0351	phosphomethylpyrimidine kinase
HVY75_RS05625	COG5455	response to cobalt ion
HVY75_RS05630	COG3539	Fimbrial protein
HVY75_RS05635	COG3188	usher protein
HVY75_RS05640	COG3121	Chaperone
HVY75_RS05655	COG0489	protein tyrosine kinase activity
HVY75_RS05665	COG3831	ATPase activity
HVY75_RS05670	COG3831	ATPase activity
HVY75_RS05675	COG3831	ATPase activity
HVY75_RS05685	COG0714	Associated with various cellular activities
HVY75_RS05690	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVY75_RS05695	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVY75_RS05700	COG4715	Zinc finger, swim domain protein
HVY75_RS05705	COG4808	Protein conserved in bacteria
HVY75_RS05710	COG4807	Protein conserved in bacteria
HVY75_RS05720	COG3275	phosphorelay sensor kinase activity
HVY75_RS05725	COG0789	Transcriptional regulator
HVY75_RS05735	COG1174	glycine betaine transport
HVY75_RS05740	COG1125	glycine betaine transport
HVY75_RS05745	COG1174	glycine betaine transport
HVY75_RS05750	COG1732	Glycine betaine
HVY75_RS05755	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY75_RS05760	COG0277	FAD linked oxidase domain protein
HVY75_RS05765	COG1686	Belongs to the peptidase S11 family
HVY75_RS05775	COG0586	Pfam SNARE associated Golgi protein
HVY75_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS05790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY75_RS05800	COG1346	cytolysis
HVY75_RS05810	COG2949	membrane
HVY75_RS05820	COG0493	'glutamate synthase
HVY75_RS05825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVY75_RS05825	COG0167	dihydroorotate dehydrogenase activity
HVY75_RS05830	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVY75_RS05835	COG1129	ABC transporter
HVY75_RS05840	COG1879	ABC-type sugar transport system periplasmic component
HVY75_RS05845	COG1609	Transcriptional regulator
HVY75_RS05850	COG2311	Membrane
HVY75_RS05865	COG4771	TonB-dependent receptor
HVY75_RS05870	COG0833	amino acid
HVY75_RS05875	COG0583	DNA-binding transcription factor activity
HVY75_RS05880	COG2855	membrane
HVY75_RS05890	COG1522	sequence-specific DNA binding
HVY75_RS05890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY75_RS05895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY75_RS05905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY75_RS05910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY75_RS05915	COG2313	pseudouridylate synthase activity
HVY75_RS05920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY75_RS05925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS05925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS05925	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVY75_RS05930	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY75_RS05935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS05935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS05955	COG0246	Mannitol dehydrogenase
HVY75_RS05960	COG0523	cobalamin synthesis protein
HVY75_RS05965	COG0671	phosphoesterase, PA-phosphatase related
HVY75_RS05970	COG0791	NLP P60 protein
HVY75_RS05975	COG2200	EAL domain
HVY75_RS05980	COG4166	transmembrane transport
HVY75_RS05985	COG4174	ABC transporter (Permease)
HVY75_RS05990	COG4239	(ABC) transporter, permease
HVY75_RS05995	COG4172	Belongs to the ABC transporter superfamily
HVY75_RS06005	COG2814	Major facilitator Superfamily
HVY75_RS06010	COG1187	pseudouridine synthase activity
HVY75_RS06015	COG1061	Type III restriction enzyme res subunit
HVY75_RS06025	COG0596	Alpha beta hydrolase
HVY75_RS06040	COG3083	sulfuric ester hydrolase activity
HVY75_RS06050	COG0582	viral genome integration into host DNA
HVY75_RS06110	COG2197	response regulator
HVY75_RS06115	COG3088	subunit of a heme lyase
HVY75_RS06115	COG4235	cytochrome complex assembly
HVY75_RS06120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY75_RS06125	COG1138	Cytochrome C-type biogenesis protein
HVY75_RS06135	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY75_RS06140	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY75_RS06145	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY75_RS06155	COG3005	denitrification pathway
HVY75_RS06160	COG3043	anaerobic respiration
HVY75_RS06165	COG0348	domain, Protein
HVY75_RS06170	COG0437	4 iron, 4 sulfur cluster binding
HVY75_RS06180	COG3062	negative regulation of establishment of protein localization
HVY75_RS06185	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY75_RS06185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY75_RS06195	COG0668	transmembrane transport
HVY75_RS06210	COG4774	siderophore transport
HVY75_RS06220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY75_RS06230	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY75_RS06235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY75_RS06240	COG1199	ATP-dependent helicase activity
HVY75_RS06245	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HVY75_RS06250	COG0513	Belongs to the DEAD box helicase family
HVY75_RS06255	COG1309	transcriptional regulator
HVY75_RS06265	COG1131	(ABC) transporter
HVY75_RS06270	COG0842	Transport permease protein
HVY75_RS06275	COG0842	Transport permease protein
HVY75_RS06285	COG3568	Endonuclease Exonuclease Phosphatase
HVY75_RS06290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY75_RS06295	COG0392	lysyltransferase activity
HVY75_RS06300	COG0670	Belongs to the BI1 family
HVY75_RS06305	COG2194	sulfuric ester hydrolase activity
HVY75_RS06310	COG0670	Belongs to the BI1 family
HVY75_RS06315	COG0314	molybdopterin synthase activity
HVY75_RS06320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVY75_RS06330	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY75_RS06340	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVY75_RS06350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY75_RS06355	COG2226	methyltransferase
HVY75_RS06370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVY75_RS06375	COG1881	PFAM PEBP family protein
HVY75_RS06380	COG2246	polysaccharide biosynthetic process
HVY75_RS06385	COG0463	Glycosyl transferase, family 2
HVY75_RS06470	COG1783	phage Terminase large subunit
HVY75_RS06490	COG3646	Phage regulatory protein
HVY75_RS06505	COG3772	lysozyme
HVY75_RS06635	COG3723	Recombinational DNA repair protein, rece pathway
HVY75_RS06685	COG0582	viral genome integration into host DNA
HVY75_RS06690	COG4677	pectinesterase activity
HVY75_RS06700	COG0561	phosphatase activity
HVY75_RS06710	COG4149	molybdate abc transporter
HVY75_RS06715	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVY75_RS06725	COG3585	molybdate ion transport
HVY75_RS06725	COG2005	Transcriptional regulator
HVY75_RS06730	COG1119	ATPase activity
HVY75_RS06735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVY75_RS06740	COG1085	galactose-1-phosphate uridylyltransferase
HVY75_RS06750	COG2017	converts alpha-aldose to the beta-anomer
HVY75_RS06760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY75_RS06770	COG1230	cation diffusion facilitator family transporter
HVY75_RS06775	COG3201	nicotinamide mononucleotide transporter
HVY75_RS06825	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVY75_RS06830	COG2885	chlorophyll binding
HVY75_RS06840	COG3064	Membrane
HVY75_RS06845	COG0848	biopolymer transport protein
HVY75_RS06850	COG0811	peptide transport
HVY75_RS06855	COG0824	Thioesterase
HVY75_RS06860	COG3790	cyd operon protein YbgE
HVY75_RS06865	COG4890	Cyd operon protein YbgT
HVY75_RS06870	COG1294	oxidase, subunit
HVY75_RS06875	COG1271	oxidase subunit
HVY75_RS06880	COG0383	alpha-mannosidase activity
HVY75_RS06885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS06885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS06885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS06890	COG2188	Transcriptional regulator
HVY75_RS06895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY75_RS06905	COG4865	methylaspartate mutase activity
HVY75_RS06910	COG3799	methylaspartate ammonia-lyase activity
HVY75_RS06925	COG1301	dicarboxylic acid transport
HVY75_RS06930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY75_RS06930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY75_RS06935	COG0583	DNA-binding transcription factor activity
HVY75_RS06940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY75_RS06950	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY75_RS06955	COG0567	Dehydrogenase, E1 component
HVY75_RS06960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY75_RS06965	COG1053	succinate dehydrogenase
HVY75_RS06970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVY75_RS06975	COG2009	succinate dehydrogenase
HVY75_RS06980	COG0372	Belongs to the citrate synthase family
HVY75_RS06995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY75_RS07005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY75_RS07010	COG2721	sulfolactate sulfo-lyase activity
HVY75_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS07025	COG1063	alcohol dehydrogenase
HVY75_RS07030	COG0473	3-isopropylmalate dehydrogenase activity
HVY75_RS07030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HVY75_RS07035	COG2186	Transcriptional regulator
HVY75_RS07040	COG3539	Fimbrial protein
HVY75_RS07045	COG3188	usher protein
HVY75_RS07050	COG3121	Chaperone
HVY75_RS07055	COG3539	Fimbrial protein
HVY75_RS07060	COG3180	Ammonia monooxygenase
HVY75_RS07085	COG1984	allophanate hydrolase subunit 2
HVY75_RS07090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVY75_RS07095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVY75_RS07105	COG0415	Belongs to the DNA photolyase family
HVY75_RS07110	COG3272	Protein of unknown function (DUF1722)
HVY75_RS07165	COG2205	protein histidine kinase activity
HVY75_RS07170	COG0745	RESPONSE REGULATOR receiver
HVY75_RS07175	COG1982	Orn Lys Arg decarboxylase major
HVY75_RS07180	COG0531	amino acid
HVY75_RS07185	COG0033	Phosphoglucomutase
HVY75_RS07190	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVY75_RS07195	COG0596	Alpha beta hydrolase
HVY75_RS07205	COG0716	FMN binding
HVY75_RS07215	COG0735	belongs to the Fur family
HVY75_RS07235	COG2190	(PTS) system
HVY75_RS07235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY75_RS07235	COG1263	PTS System
HVY75_RS07245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY75_RS07250	COG1940	carbohydrate kinase activity
HVY75_RS07250	COG1846	Transcriptional regulator
HVY75_RS07255	COG0647	UMP catabolic process
HVY75_RS07260	COG0367	asparagine synthase
HVY75_RS07310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY75_RS07320	COG1702	phosphate starvation-inducible protein PhoH
HVY75_RS07330	COG4535	Mg2 and Co2 transporter CorC
HVY75_RS07335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVY75_RS07345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY75_RS07350	COG0765	amino acid transport
HVY75_RS07355	COG0765	amino acid transport
HVY75_RS07360	COG1126	abc transporter atp-binding protein
HVY75_RS07370	COG0443	Heat shock 70 kDa protein
HVY75_RS07375	COG2214	Heat shock protein DnaJ domain protein
HVY75_RS07385	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY75_RS07390	COG2214	Heat shock protein DnaJ domain protein
HVY75_RS07400	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY75_RS07405	COG2888	peptidyl-tyrosine sulfation
HVY75_RS07420	COG1466	dna polymerase III delta subunit
HVY75_RS07430	COG0799	negative regulation of ribosome biogenesis
HVY75_RS07440	COG0768	penicillin binding
HVY75_RS07445	COG0772	Belongs to the SEDS family
HVY75_RS07450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY75_RS07455	COG1686	Belongs to the peptidase S11 family
HVY75_RS07480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY75_RS07500	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY75_RS07505	COG3719	Belongs to the RNase T2 family
HVY75_RS07510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY75_RS07515	COG0589	response to stress
HVY75_RS07520	COG3634	alkyl hydroperoxide reductase activity
HVY75_RS07525	COG0450	alkyl hydroperoxide reductase
HVY75_RS07530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY75_RS07535	COG0583	DNA-binding transcription factor activity
HVY75_RS07540	COG3969	phosphoadenosine phosphosulfate
HVY75_RS07545	COG1475	DNA binding
HVY75_RS07550	COG0436	Aminotransferase
HVY75_RS07555	COG0371	Dehydrogenase
HVY75_RS07560	COG2879	small protein
HVY75_RS07565	COG1966	Carbon starvation protein
HVY75_RS07570	COG2050	protein possibly involved in aromatic compounds catabolism
HVY75_RS07575	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS07580	COG3433	isochorismatase activity
HVY75_RS07580	COG1535	isochorismatase
HVY75_RS07585	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVY75_RS07590	COG1169	isochorismate synthase
HVY75_RS07595	COG4592	Periplasmic binding protein
HVY75_RS07605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY75_RS07610	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY75_RS07615	COG1120	ATPase activity
HVY75_RS07620	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY75_RS07625	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVY75_RS07625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVY75_RS07630	COG3251	PFAM MbtH domain protein
HVY75_RS07635	COG2382	esterase
HVY75_RS07640	COG4771	TonB-dependent receptor
HVY75_RS07645	COG2977	Belongs to the P-Pant transferase superfamily
HVY75_RS07670	COG2315	Protein conserved in bacteria
HVY75_RS07675	COG0778	Nitroreductase
HVY75_RS07680	COG0668	transmembrane transport
HVY75_RS07685	COG1113	amino acid transport
HVY75_RS07690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY75_RS07695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS07700	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS07705	COG1538	Outer membrane efflux protein
HVY75_RS07710	COG0745	RESPONSE REGULATOR receiver
HVY75_RS07715	COG5002	protein histidine kinase activity
HVY75_RS07750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVY75_RS07760	COG2832	Protein of unknown function (DUF454)
HVY75_RS07765	COG3923	Primosomal replication protein n
HVY75_RS07775	COG3264	Mechanosensitive ion channel
HVY75_RS07775	COG1196	nuclear chromosome segregation
HVY75_RS07780	COG1309	transcriptional regulator
HVY75_RS07785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS07790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY75_RS07810	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY75_RS07815	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVY75_RS07825	COG3695	enzyme binding
HVY75_RS07830	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVY75_RS07835	COG1946	Acyl-CoA thioesterase
HVY75_RS07840	COG0004	ammonium transporteR
HVY75_RS07845	COG0347	Belongs to the P(II) protein family
HVY75_RS07850	COG1132	(ABC) transporter
HVY75_RS07855	COG1132	(ABC) transporter
HVY75_RS07860	COG1522	sequence-specific DNA binding
HVY75_RS07870	COG4533	DNA binding
HVY75_RS07880	COG0824	Thioesterase
HVY75_RS07885	COG1555	photosystem II stabilization
HVY75_RS07890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY75_RS07895	COG0776	regulation of translation
HVY75_RS07900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVY75_RS07920	COG0271	Belongs to the BolA IbaG family
HVY75_RS07925	COG3056	Lipoprotein
HVY75_RS07930	COG2223	nitrite transmembrane transporter activity
HVY75_RS07935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVY75_RS07940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVY75_RS07945	COG1845	cytochrome c oxidase, subunit III
HVY75_RS07950	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVY75_RS07970	COG1414	Transcriptional regulator
HVY75_RS07975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVY75_RS07990	COG1053	succinate dehydrogenase
HVY75_RS08005	COG2814	Major facilitator Superfamily
HVY75_RS08015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVY75_RS08020	COG0693	protein deglycase activity
HVY75_RS08035	COG0142	geranyltranstransferase activity
HVY75_RS08045	COG0667	Aldo Keto reductase
HVY75_RS08050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVY75_RS08070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY75_RS08070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY75_RS08080	COG4238	major outer membrane lipoprotein
HVY75_RS08085	COG3248	Nucleoside-binding outer membrane protein
HVY75_RS08095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY75_RS08100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY75_RS08105	COG1862	Preprotein translocase
HVY75_RS08125	COG0366	Alpha amylase catalytic
HVY75_RS08130	COG1113	amino acid transport
HVY75_RS08135	COG1114	Component of the transport system for branched-chain amino acids
HVY75_RS08140	COG5002	protein histidine kinase activity
HVY75_RS08150	COG0420	3'-5' exonuclease activity
HVY75_RS08155	COG0419	ATPase involved in DNA repair
HVY75_RS08160	COG1940	carbohydrate kinase activity
HVY75_RS08175	COG4126	flavin adenine dinucleotide binding
HVY75_RS08195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVY75_RS08200	COG3706	GGDEF domain
HVY75_RS08220	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY75_RS08240	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVY75_RS08245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY75_RS08250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY75_RS08260	COG0113	porphobilinogen synthase activity
HVY75_RS08265	COG2175	clavaminate synthase activity
HVY75_RS08270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY75_RS08280	COG4521	taurine ABC transporter
HVY75_RS08285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HVY75_RS08295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY75_RS08300	COG2079	MmgE PrpD family protein
HVY75_RS08305	COG0372	Belongs to the citrate synthase family
HVY75_RS08310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVY75_RS08315	COG3829	transcription factor binding
HVY75_RS08325	COG1280	lysine exporter protein (LysE YggA)
HVY75_RS08330	COG3706	GGDEF domain
HVY75_RS08335	COG2186	Transcriptional regulator
HVY75_RS08340	COG1063	alcohol dehydrogenase
HVY75_RS08345	COG2271	Major facilitator Superfamily
HVY75_RS08350	COG2200	EAL domain
HVY75_RS08360	COG2200	EAL domain
HVY75_RS08360	COG2771	luxR family
HVY75_RS08365	COG0454	-acetyltransferase
HVY75_RS08370	COG0656	L-ascorbic acid biosynthetic process
HVY75_RS08375	COG0667	Aldo Keto reductase
HVY75_RS08400	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY75_RS08405	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY75_RS08520	COG3772	lysozyme
HVY75_RS08530	COG2207	Transcriptional regulator
HVY75_RS08535	COG3272	Protein of unknown function (DUF1722)
HVY75_RS08590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY75_RS08600	COG2076	Multidrug Resistance protein
HVY75_RS08695	COG0582	viral genome integration into host DNA
HVY75_RS08715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY75_RS08735	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVY75_RS08750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY75_RS08755	COG1690	Belongs to the RtcB family
HVY75_RS08760	COG0454	-acetyltransferase
HVY75_RS08765	COG2161	toxin-antitoxin pair type II binding
HVY75_RS08785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY75_RS08790	COG1074	ATP-dependent DNA helicase activity
HVY75_RS08795	COG1025	Belongs to the peptidase M16 family
HVY75_RS08800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVY75_RS08805	COG4967	type IV pilus modification protein PilV
HVY75_RS08815	COG4795	General secretion pathway protein
HVY75_RS08820	COG2165	general secretion pathway protein
HVY75_RS08850	COG0861	Integral membrane protein TerC family
HVY75_RS08860	COG0667	Aldo Keto reductase
HVY75_RS08885	COG1609	Transcriptional regulator
HVY75_RS08895	COG0583	DNA-binding transcription factor activity
HVY75_RS08900	COG0183	Belongs to the thiolase family
HVY75_RS08905	COG0814	amino acid
HVY75_RS08910	COG2771	luxR family
HVY75_RS08915	COG3710	Transcriptional regulator
HVY75_RS08925	COG1215	transferase activity, transferring glycosyl groups
HVY75_RS08930	COG4783	chaperone-mediated protein folding
HVY75_RS08940	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY75_RS08945	COG0402	S-adenosylhomocysteine deaminase activity
HVY75_RS08965	COG1388	LysM domain
HVY75_RS08965	COG1470	cell adhesion involved in biofilm formation
HVY75_RS09075	COG4942	peptidase
HVY75_RS09080	COG0235	Class ii aldolase
HVY75_RS09095	COG1126	abc transporter atp-binding protein
HVY75_RS09100	COG0583	DNA-binding transcription factor activity
HVY75_RS09105	COG2072	flavoprotein involved in K transport
HVY75_RS09120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY75_RS09125	COG0076	glutamate decarboxylase activity
HVY75_RS09130	COG2066	Belongs to the glutaminase family
HVY75_RS09135	COG2080	2 iron, 2 sulfur cluster binding
HVY75_RS09140	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVY75_RS09145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVY75_RS09150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVY75_RS09165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVY75_RS09175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVY75_RS09180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY75_RS09185	COG4974	Belongs to the 'phage' integrase family
HVY75_RS09190	COG0716	FMN binding
HVY75_RS09200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVY75_RS09210	COG1272	protein, Hemolysin III
HVY75_RS09220	COG2723	6-phospho-beta-galactosidase activity
HVY75_RS09250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY75_RS09255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY75_RS09260	COG0006	proline dipeptidase activity
HVY75_RS09280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVY75_RS09290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY75_RS09305	COG2968	Membrane
HVY75_RS09310	COG1279	arginine transmembrane transporter activity
HVY75_RS09315	COG0668	transmembrane transport
HVY75_RS09320	COG0191	fructose-bisphosphate aldolase activity
HVY75_RS09335	COG1072	(Pantothenic acid kinase))
HVY75_RS09345	COG1494	fructose-1,6-bisphosphatase
HVY75_RS09350	COG1063	alcohol dehydrogenase
HVY75_RS09355	COG2213	PTS system mannitol-specific
HVY75_RS09360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS09365	COG0330	HflC and HflK could
HVY75_RS09370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY75_RS09375	COG0501	Belongs to the peptidase M48B family
HVY75_RS09405	COG1166	arginine decarboxylase activity
HVY75_RS09430	COG2814	Major facilitator Superfamily
HVY75_RS09440	COG2356	endonuclease I
HVY75_RS09445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVY75_RS09450	COG0189	ligase activity
HVY75_RS09465	COG2805	Type II/IV secretion system protein
HVY75_RS09470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVY75_RS09475	COG0762	integral membrane protein
HVY75_RS09490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY75_RS09495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY75_RS09500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY75_RS09515	COG0252	asparaginase activity
HVY75_RS09525	COG3171	Protein conserved in bacteria
HVY75_RS09535	COG1194	a g-specific adenine glycosylase
HVY75_RS09550	COG2211	Major facilitator Superfamily
HVY75_RS09555	COG1982	Orn Lys Arg decarboxylase major
HVY75_RS09560	COG1811	Na channel or pump
HVY75_RS09585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HVY75_RS09595	COG3031	protein transport across the cell outer membrane
HVY75_RS09605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY75_RS09610	COG1459	type II secretion system
HVY75_RS09615	COG2165	general secretion pathway protein
HVY75_RS09630	COG4795	General secretion pathway protein
HVY75_RS09645	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HVY75_RS09655	COG5433	transposase activity
HVY75_RS09665	COG0754	glutathionylspermidine amidase activity
HVY75_RS09670	COG2207	Transcriptional regulator
HVY75_RS09675	COG0625	glutathione transferase activity
HVY75_RS09680	COG0298	carbon dioxide binding
HVY75_RS09690	COG1773	rubredoxin
HVY75_RS09695	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY75_RS09700	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY75_RS09705	COG5557	Pfam Polysulphide reductase, NrfD
HVY75_RS09710	COG0437	4 iron, 4 sulfur cluster binding
HVY75_RS09715	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY75_RS09730	COG0667	Aldo Keto reductase
HVY75_RS09740	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS09745	COG0848	biopolymer transport protein
HVY75_RS09750	COG0811	peptide transport
HVY75_RS09755	COG0626	cystathionine gamma-synthase activity
HVY75_RS09760	COG0586	Pfam SNARE associated Golgi protein
HVY75_RS09765	COG2207	Transcriptional regulator
HVY75_RS09770	COG1979	alcohol dehydrogenase
HVY75_RS09775	COG0656	L-ascorbic acid biosynthetic process
HVY75_RS09780	COG0471	metal ion transport
HVY75_RS09785	COG4238	major outer membrane lipoprotein
HVY75_RS09790	COG1032	radical SAM domain protein
HVY75_RS09795	COG2186	Transcriptional regulator
HVY75_RS09800	COG0246	Mannitol dehydrogenase
HVY75_RS09805	COG1063	alcohol dehydrogenase
HVY75_RS09810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY75_RS09835	COG0204	Acyl-transferase
HVY75_RS09840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY75_RS09845	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY75_RS09850	COG0745	RESPONSE REGULATOR receiver
HVY75_RS09855	COG0642	Histidine kinase
HVY75_RS09860	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVY75_RS09865	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVY75_RS09870	COG0187	DNA topoisomerase II activity
HVY75_RS09875	COG3150	esterase
HVY75_RS09880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVY75_RS09885	COG3151	Protein conserved in bacteria
HVY75_RS09890	COG0494	nUDIX hydrolase
HVY75_RS09895	COG1538	Outer membrane efflux protein
HVY75_RS09905	COG0754	glutathionylspermidine amidase activity
HVY75_RS09915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HVY75_RS09925	COG3384	dioxygenase
HVY75_RS09940	COG3539	Fimbrial protein
HVY75_RS09945	COG3188	usher protein
HVY75_RS09950	COG3121	Chaperone
HVY75_RS09955	COG3539	Fimbrial protein
HVY75_RS09975	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY75_RS09980	COG2268	Band 7 protein
HVY75_RS10010	COG3025	triphosphatase activity
HVY75_RS10015	COG4991	sh3 domain protein
HVY75_RS10030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY75_RS10045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVY75_RS10050	COG0358	DNA primase activity
HVY75_RS10055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY75_RS10115	COG3118	belongs to the thioredoxin family
HVY75_RS10125	COG2375	cellular response to nickel ion
HVY75_RS10130	COG1695	Transcriptional regulator
HVY75_RS10135	COG0840	transmembrane signaling receptor activity
HVY75_RS10145	COG0477	Major facilitator Superfamily
HVY75_RS10150	COG3501	Rhs element vgr protein
HVY75_RS10155	COG2186	Transcriptional regulator
HVY75_RS10160	COG0246	Mannitol dehydrogenase
HVY75_RS10170	COG3065	identical protein binding
HVY75_RS10175	COG2197	response regulator
HVY75_RS10180	COG1285	pathogenesis
HVY75_RS10195	COG3247	response to pH
HVY75_RS10200	COG2771	luxR family
HVY75_RS10205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS10210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY75_RS10215	COG2207	Transcriptional regulator
HVY75_RS10230	COG1846	Transcriptional regulator
HVY75_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS10260	COG4638	Rieske (2fe-2S)
HVY75_RS10265	COG0633	Ferredoxin
HVY75_RS10270	COG2271	Major facilitator Superfamily
HVY75_RS10290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY75_RS10295	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVY75_RS10300	COG1924	4 iron, 4 sulfur cluster binding
HVY75_RS10310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVY75_RS10310	COG1902	pentaerythritol trinitrate reductase activity
HVY75_RS10315	COG0840	transmembrane signaling receptor activity
HVY75_RS10325	COG4145	pantothenate transmembrane transporter activity
HVY75_RS10335	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HVY75_RS10345	COG1846	Transcriptional regulator
HVY75_RS10350	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY75_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS10360	COG3384	dioxygenase
HVY75_RS10370	COG3971	2-oxopent-4-enoate hydratase activity
HVY75_RS10390	COG2368	4-hydroxyphenylacetate
HVY75_RS10395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY75_RS10400	COG1966	Carbon starvation protein
HVY75_RS10405	COG2879	small protein
HVY75_RS10410	COG0523	cobalamin synthesis protein
HVY75_RS10430	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HVY75_RS10435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVY75_RS10450	COG1401	restriction endodeoxyribonuclease activity
HVY75_RS10455	COG4268	DNA restriction-modification system
HVY75_RS10470	COG5457	Domain of unknown function (DUF1127)
HVY75_RS10475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY75_RS10485	COG2814	Major facilitator Superfamily
HVY75_RS10490	COG2733	membrane
HVY75_RS10500	COG3436	PFAM IS66 Orf2 family protein
HVY75_RS10510	COG0720	synthase
HVY75_RS10545	COG0514	ATP-dependent DNA helicase (RecQ)
HVY75_RS10585	COG1064	alcohol dehydrogenase
HVY75_RS10590	COG0433	COG0433 Predicted ATPase
HVY75_RS10595	COG0701	Predicted permease
HVY75_RS10600	COG0702	epimerase
HVY75_RS10605	COG0693	protein deglycase activity
HVY75_RS10620	COG3153	acetyltransferase
HVY75_RS10625	COG3154	lipid carrier protein
HVY75_RS10630	COG0826	peptidase U32
HVY75_RS10635	COG0826	peptidase U32
HVY75_RS10640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY75_RS10645	COG3034	peptidoglycan biosynthetic process
HVY75_RS10690	COG0511	ligase activity, forming carbon-carbon bonds
HVY75_RS10715	COG0814	amino acid
HVY75_RS10720	COG0513	Belongs to the DEAD box helicase family
HVY75_RS10760	COG0195	Participates in both transcription termination and antitermination
HVY75_RS10780	COG2194	sulfuric ester hydrolase activity
HVY75_RS10790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY75_RS10800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVY75_RS10805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVY75_RS10815	COG1534	Rna-binding protein
HVY75_RS10820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY75_RS10825	COG2027	D-alanyl-D-alanine carboxypeptidase
HVY75_RS10835	COG0697	spore germination
HVY75_RS10850	COG0142	geranyltranstransferase activity
HVY75_RS10855	COG3423	Transcriptional regulator
HVY75_RS10865	COG5007	Belongs to the BolA IbaG family
HVY75_RS10870	COG3113	response to antibiotic
HVY75_RS10875	COG2854	intermembrane phospholipid transfer
HVY75_RS10880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY75_RS10885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVY75_RS10890	COG1127	ABC transporter
HVY75_RS10895	COG0530	calcium, potassium:sodium antiporter activity
HVY75_RS10900	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY75_RS10900	COG0517	IMP dehydrogenase activity
HVY75_RS10905	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVY75_RS10910	COG3117	lipopolysaccharide transmembrane transporter activity
HVY75_RS10915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVY75_RS10920	COG1137	ATPase activity
HVY75_RS10925	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVY75_RS10930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY75_RS10945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS10950	COG0515	serine threonine protein kinase
HVY75_RS10960	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVY75_RS10965	COG0784	Response regulator, receiver
HVY75_RS10965	COG2198	Histidine kinase
HVY75_RS10965	COG5002	protein histidine kinase activity
HVY75_RS10970	COG1242	4 iron, 4 sulfur cluster binding
HVY75_RS10975	COG0067	glutamate synthase
HVY75_RS10975	COG0069	glutamate synthase activity
HVY75_RS10975	COG0070	glutamate synthase
HVY75_RS10980	COG0493	'glutamate synthase
HVY75_RS10985	COG4804	nuclease activity
HVY75_RS10990	COG2731	YhcH YjgK YiaL family protein
HVY75_RS11020	COG2969	positive regulation of protein catabolic process
HVY75_RS11025	COG0625	glutathione transferase activity
HVY75_RS11040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVY75_RS11045	COG3105	Protein conserved in bacteria
HVY75_RS11050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY75_RS11055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY75_RS11065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY75_RS11070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY75_RS11075	COG0471	metal ion transport
HVY75_RS11085	COG1802	Transcriptional regulator
HVY75_RS11105	COG2732	(Barnase) inhibitor
HVY75_RS11125	COG0583	DNA-binding transcription factor activity
HVY75_RS11130	COG0312	modulator of DNA gyrase
HVY75_RS11135	COG3164	Protein of unknown function
HVY75_RS11140	COG1530	ribonuclease E activity
HVY75_RS11150	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVY75_RS11155	COG1792	Involved in formation and maintenance of cell shape
HVY75_RS11160	COG1077	Cell shape determining protein MreB Mrl
HVY75_RS11165	COG2200	EAL domain
HVY75_RS11165	COG2199	diguanylate cyclase activity
HVY75_RS11170	COG0604	alcohol dehydrogenase
HVY75_RS11185	COG0511	ligase activity, forming carbon-carbon bonds
HVY75_RS11190	COG0439	Biotin carboxylase
HVY75_RS11195	COG3924	membrane
HVY75_RS11200	COG4145	pantothenate transmembrane transporter activity
HVY75_RS11210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY75_RS11220	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVY75_RS11230	COG1309	transcriptional regulator
HVY75_RS11235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS11240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY75_RS11250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY75_RS11255	COG4597	amino acid ABC transporter
HVY75_RS11260	COG0765	amino acid transport
HVY75_RS11265	COG1126	abc transporter atp-binding protein
HVY75_RS11305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY75_RS11325	COG0551	DNA topoisomerase type I activity
HVY75_RS11335	COG0758	DNA mediated transformation
HVY75_RS11355	COG0569	domain protein
HVY75_RS11365	COG3036	rescue of stalled ribosome
HVY75_RS11370	COG0789	Transcriptional regulator
HVY75_RS11410	COG0201	protein transport
HVY75_RS11500	COG0089	rRNA binding
HVY75_RS11515	COG0051	transcription antitermination factor activity, RNA binding
HVY75_RS11570	COG2964	Protein conserved in bacteria
HVY75_RS11575	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY75_RS11585	COG1047	Peptidyl-prolyl cis-trans
HVY75_RS11590	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVY75_RS11605	COG0488	(ABC) transporter
HVY75_RS11610	COG0429	hydrolase of the alpha beta-hydrolase fold
HVY75_RS11620	COG3954	Phosphoribulokinase
HVY75_RS11625	COG1765	OsmC-like protein
HVY75_RS11630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY75_RS11635	COG1289	transmembrane transporter activity
HVY75_RS11640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVY75_RS11645	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY75_RS11650	COG2184	nucleotidyltransferase activity
HVY75_RS11665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY75_RS11670	COG2146	nitrite reductase [NAD(P)H] activity
HVY75_RS11675	COG2116	formate transmembrane transporter activity
HVY75_RS11690	COG0626	cystathionine gamma-synthase activity
HVY75_RS11705	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVY75_RS11710	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVY75_RS11715	COG3457	Alanine racemase
HVY75_RS11725	COG2188	Transcriptional regulator
HVY75_RS11730	COG0180	Tryptophanyl-tRNA synthetase
HVY75_RS11740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY75_RS11745	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVY75_RS11750	COG3266	domain, Protein
HVY75_RS11765	COG4796	Type ii and iii secretion system protein
HVY75_RS11780	COG3166	PFAM Fimbrial assembly family protein
HVY75_RS11785	COG4972	Pilus assembly protein
HVY75_RS11790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVY75_RS11795	COG0494	nUDIX hydrolase
HVY75_RS11805	COG1011	Hydrolase
HVY75_RS11810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVY75_RS11820	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY75_RS11840	COG2205	protein histidine kinase activity
HVY75_RS11845	COG0745	RESPONSE REGULATOR receiver
HVY75_RS11850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY75_RS11855	COG2183	response to ionizing radiation
HVY75_RS11860	COG1918	ferrous iron import across plasma membrane
HVY75_RS11865	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVY75_RS11875	COG5464	transposase or invertase
HVY75_RS11895	COG2610	gluconate transmembrane transporter activity
HVY75_RS11905	COG1640	4-alpha-glucanotransferase
HVY75_RS11910	COG0058	SHG alpha-glucan phosphorylase activity
HVY75_RS11925	COG1690	Belongs to the RtcB family
HVY75_RS11930	COG4650	regulator
HVY75_RS11935	COG1349	DNA-binding transcription factor activity
HVY75_RS11950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY75_RS11965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY75_RS11975	COG3121	Chaperone
HVY75_RS11985	COG3539	Fimbrial protein
HVY75_RS11990	COG3188	usher protein
HVY75_RS11995	COG3121	Chaperone
HVY75_RS12005	COG0058	SHG alpha-glucan phosphorylase activity
HVY75_RS12030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY75_RS12035	COG2095	MarC family integral membrane protein
HVY75_RS12040	COG2610	gluconate transmembrane transporter activity
HVY75_RS12045	COG3265	gluconokinase activity
HVY75_RS12050	COG1609	Transcriptional regulator
HVY75_RS12055	COG1741	Belongs to the pirin family
HVY75_RS12060	COG0673	inositol 2-dehydrogenase activity
HVY75_RS12065	COG1247	-acetyltransferase
HVY75_RS12070	COG3157	Type VI secretion system effector, Hcp
HVY75_RS12080	COG0405	Gamma-glutamyltransferase
HVY75_RS12090	COG0584	glycerophosphoryl diester phosphodiesterase
HVY75_RS12105	COG1175	transmembrane transport
HVY75_RS12110	COG1653	transport
HVY75_RS12115	COG0410	ABC transporter
HVY75_RS12120	COG0411	ABC transporter
HVY75_RS12125	COG4177	L-phenylalanine transmembrane transporter activity
HVY75_RS12130	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVY75_RS12135	COG0683	leucine binding
HVY75_RS12140	COG0456	acetyltransferase
HVY75_RS12145	COG0683	leucine binding
HVY75_RS12150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY75_RS12155	COG2177	Part of the ABC transporter FtsEX involved in
HVY75_RS12160	COG2884	Cell division ATP-binding protein ftsE
HVY75_RS12165	COG0552	protein localization to endoplasmic reticulum
HVY75_RS12170	COG0742	ribosomal rna small subunit methyltransferase
HVY75_RS12175	COG3776	membrane
HVY75_RS12185	COG3714	YhhN family
HVY75_RS12200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVY75_RS12215	COG0628	permease
HVY75_RS12235	COG0204	Acyl-transferase
HVY75_RS12245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVY75_RS12265	COG1216	Glycosyl transferase, family 2
HVY75_RS12290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY75_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS12305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY75_RS12310	COG2091	lysine biosynthetic process via aminoadipic acid
HVY75_RS12320	COG0842	Transport permease protein
HVY75_RS12325	COG1129	ABC transporter
HVY75_RS12325	COG0842	Transport permease protein
HVY75_RS12330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS12355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS12360	COG2081	HI0933 family
HVY75_RS12365	COG0306	phosphate transporter
HVY75_RS12375	COG0589	response to stress
HVY75_RS12380	COG3104	oligopeptide transport
HVY75_RS12390	COG0339	signal peptide processing
HVY75_RS12395	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVY75_RS12400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY75_RS12415	COG0640	Transcriptional regulator
HVY75_RS12420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY75_RS12425	COG1393	Belongs to the ArsC family
HVY75_RS12445	COG2197	response regulator
HVY75_RS12450	COG1295	ribonuclease BN
HVY75_RS12455	COG0477	Major facilitator Superfamily
HVY75_RS12460	COG2982	Protein involved in outer membrane biogenesis
HVY75_RS12465	COG2200	EAL domain
HVY75_RS12470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY75_RS12485	COG0612	Peptidase, M16
HVY75_RS12495	COG2199	diguanylate cyclase activity
HVY75_RS12495	COG2200	EAL domain
HVY75_RS12500	COG0457	Tetratricopeptide repeat
HVY75_RS12500	COG3118	belongs to the thioredoxin family
HVY75_RS12505	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVY75_RS12510	COG1215	transferase activity, transferring glycosyl groups
HVY75_RS12515	COG1215	transferase activity, transferring glycosyl groups
HVY75_RS12540	COG2194	sulfuric ester hydrolase activity
HVY75_RS12560	COG0626	cystathionine gamma-synthase activity
HVY75_RS12565	COG0814	amino acid
HVY75_RS12575	COG4608	Belongs to the ABC transporter superfamily
HVY75_RS12580	COG0444	Belongs to the ABC transporter superfamily
HVY75_RS12585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY75_RS12590	COG0601	transmembrane transport
HVY75_RS12595	COG0747	negative chemotaxis
HVY75_RS12610	COG2194	sulfuric ester hydrolase activity
HVY75_RS12615	COG2223	nitrite transmembrane transporter activity
HVY75_RS12620	COG5571	outer membrane autotransporter
HVY75_RS12625	COG2818	Glycosylase
HVY75_RS12630	COG0456	acetyltransferase
HVY75_RS12635	COG0243	molybdopterin cofactor binding
HVY75_RS12640	COG2885	chlorophyll binding
HVY75_RS12645	COG1609	Transcriptional regulator
HVY75_RS12655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY75_RS12675	COG2814	Major facilitator Superfamily
HVY75_RS12680	COG2944	sequence-specific DNA binding
HVY75_RS12685	COG1278	Cold shock
HVY75_RS12720	COG3274	enterobacterial common antigen metabolic process
HVY75_RS12725	COG4682	membrane
HVY75_RS12730	COG1070	Carbohydrate kinase
HVY75_RS12740	COG2207	Transcriptional regulator
HVY75_RS12740	COG1609	Transcriptional regulator
HVY75_RS12745	COG2992	FlgJ-related protein
HVY75_RS12750	COG0366	Alpha amylase catalytic
HVY75_RS12755	COG3977	Valine--pyruvate aminotransferase
HVY75_RS12760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY75_RS12765	COG1414	Transcriptional regulator
HVY75_RS12775	COG2731	YhcH YjgK YiaL family protein
HVY75_RS12780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY75_RS12785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY75_RS12790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY75_RS12795	COG1070	Carbohydrate kinase
HVY75_RS12800	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HVY75_RS12805	COG3623	hexulose-6-phosphate isomerase
HVY75_RS12810	COG0235	Class ii aldolase
HVY75_RS12815	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS12820	COG1454	alcohol dehydrogenase
HVY75_RS12825	COG3276	selenocysteine insertion sequence binding
HVY75_RS12835	COG0625	glutathione transferase activity
HVY75_RS12840	COG1566	PFAM secretion protein HlyD family protein
HVY75_RS12850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS12850	COG2213	PTS system mannitol-specific
HVY75_RS12860	COG3722	fumarate hydratase activity
HVY75_RS12880	COG5295	Hep Hag repeat protein
HVY75_RS12890	COG2186	Transcriptional regulator
HVY75_RS12900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVY75_RS12905	COG1045	serine acetyltransferase
HVY75_RS12920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY75_RS12925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY75_RS12935	COG4942	peptidase
HVY75_RS12940	COG2861	carbohydrate metabolic process
HVY75_RS12945	COG1216	Glycosyl transferase, family 2
HVY75_RS12950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY75_RS12955	COG3078	GTPase activator activity
HVY75_RS12970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVY75_RS12970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVY75_RS12975	COG0204	Acyl-transferase
HVY75_RS12980	COG5339	Protein conserved in bacteria
HVY75_RS12985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY75_RS12990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVY75_RS12995	COG3084	Protein conserved in bacteria
HVY75_RS13000	COG0746	molybdenum cofactor guanylyltransferase activity
HVY75_RS13005	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVY75_RS13035	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVY75_RS13040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY75_RS13045	COG1739	Uncharacterized protein family UPF0029
HVY75_RS13070	COG0543	2 iron, 2 sulfur cluster binding
HVY75_RS13075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY75_RS13080	COG0250	Participates in transcription elongation, termination and antitermination
HVY75_RS13090	COG0805	protein transport
HVY75_RS13100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY75_RS13110	COG3165	ubiquinone biosynthetic process from chorismate
HVY75_RS13120	COG1322	Protein conserved in bacteria
HVY75_RS13125	COG1414	Transcriptional regulator
HVY75_RS13130	COG3734	2-keto-3-deoxy-galactonokinase
HVY75_RS13135	COG0800	Aldolase
HVY75_RS13155	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVY75_RS13160	COG0412	Dienelactone hydrolase
HVY75_RS13165	COG2188	Transcriptional regulator
HVY75_RS13185	COG0583	DNA-binding transcription factor activity
HVY75_RS13200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HVY75_RS13205	COG2828	Protein conserved in bacteria
HVY75_RS13210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY75_RS13215	COG0473	3-isopropylmalate dehydrogenase activity
HVY75_RS13220	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVY75_RS13235	COG0583	DNA-binding transcription factor activity
HVY75_RS13240	COG0697	spore germination
HVY75_RS13245	COG0561	phosphatase activity
HVY75_RS13250	COG2267	carboxylic ester hydrolase activity
HVY75_RS13255	COG1280	lysine exporter protein (LysE YggA)
HVY75_RS13265	COG1280	lysine exporter protein (LysE YggA)
HVY75_RS13270	COG0514	ATP-dependent DNA helicase (RecQ)
HVY75_RS13280	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVY75_RS13285	COG2050	protein possibly involved in aromatic compounds catabolism
HVY75_RS13290	COG2962	Rard protein
HVY75_RS13305	COG0598	Magnesium transport protein CorA
HVY75_RS13310	COG3698	Phosphodiester glycosidase
HVY75_RS13315	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HVY75_RS13320	COG0210	DNA helicase
HVY75_RS13325	COG1011	Hydrolase
HVY75_RS13335	COG3159	Protein conserved in bacteria
HVY75_RS13345	COG5567	small periplasmic lipoprotein
HVY75_RS13365	COG3072	Adenylate cyclase
HVY75_RS13380	COG2959	enzyme of heme biosynthesis
HVY75_RS13385	COG3071	HemY protein
HVY75_RS13395	COG3119	arylsulfatase activity
HVY75_RS13400	COG0641	radical SAM
HVY75_RS13425	COG1113	amino acid transport
HVY75_RS13445	COG2244	polysaccharide biosynthetic process
HVY75_RS13450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVY75_RS13455	COG0456	acetyltransferase
HVY75_RS13460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY75_RS13465	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY75_RS13470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVY75_RS13475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVY75_RS13480	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY75_RS13485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVY75_RS13490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVY75_RS13500	COG3118	belongs to the thioredoxin family
HVY75_RS13515	COG0210	DNA helicase
HVY75_RS13520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY75_RS13530	COG0583	DNA-binding transcription factor activity
HVY75_RS13535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY75_RS13545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY75_RS13550	COG3978	acetolactate synthase activity
HVY75_RS13570	COG0606	chelatase, subunit chli
HVY75_RS13575	COG3085	chromosome segregation
HVY75_RS13615	COG2186	Transcriptional regulator
HVY75_RS13620	COG1609	Transcriptional regulator
HVY75_RS13625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY75_RS13630	COG1879	ABC-type sugar transport system periplasmic component
HVY75_RS13635	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY75_RS13640	COG1129	ABC transporter
HVY75_RS13670	COG1522	sequence-specific DNA binding
HVY75_RS13675	COG0716	FMN binding
HVY75_RS13690	COG3312	ion transport
HVY75_RS13750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY75_RS13755	COG0573	inorganic phosphate transmembrane transporter activity
HVY75_RS13760	COG0581	inorganic phosphate transmembrane transporter activity
HVY75_RS13765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVY75_RS13770	COG0704	Plays a role in the regulation of phosphate uptake
HVY75_RS13775	COG3711	transcriptional antiterminator
HVY75_RS13780	COG2190	(PTS) system
HVY75_RS13780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY75_RS13780	COG1263	PTS System
HVY75_RS13785	COG2723	6-phospho-beta-galactosidase activity
HVY75_RS13795	COG2382	esterase
HVY75_RS13800	COG0363	glucosamine-6-phosphate deaminase activity
HVY75_RS13805	COG3196	Protein conserved in bacteria
HVY75_RS13815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY75_RS13820	COG2252	PERMEase
HVY75_RS13830	COG0431	NADPH-dependent FMN reductase
HVY75_RS13835	COG2091	lysine biosynthetic process via aminoadipic acid
HVY75_RS13850	COG0814	amino acid
HVY75_RS13900	COG0592	DNA-directed DNA polymerase activity
HVY75_RS13910	COG0187	DNA topoisomerase II activity
HVY75_RS13915	COG3753	Protein conserved in bacteria
HVY75_RS13920	COG0561	phosphatase activity
HVY75_RS13930	COG2186	Transcriptional regulator
HVY75_RS13935	COG3734	2-keto-3-deoxy-galactonokinase
HVY75_RS13940	COG0800	Aldolase
HVY75_RS13950	COG2271	Major facilitator Superfamily
HVY75_RS13960	COG0823	Involved in the tonB-independent uptake of proteins
HVY75_RS13965	COG5645	(Lipo)protein
HVY75_RS13985	COG2188	Transcriptional regulator
HVY75_RS14000	COG2149	membrane
HVY75_RS14010	COG0641	radical SAM
HVY75_RS14020	COG2610	gluconate transmembrane transporter activity
HVY75_RS14025	COG0583	DNA-binding transcription factor activity
HVY75_RS14030	COG2814	Major facilitator Superfamily
HVY75_RS14045	COG0028	Belongs to the TPP enzyme family
HVY75_RS14050	COG0440	acetolactate synthase activity
HVY75_RS14055	COG2197	response regulator
HVY75_RS14060	COG3851	Histidine kinase
HVY75_RS14065	COG2271	Major facilitator Superfamily
HVY75_RS14070	COG2271	Major facilitator Superfamily
HVY75_RS14090	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY75_RS14095	COG2723	6-phospho-beta-galactosidase activity
HVY75_RS14100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY75_RS14110	COG1609	Transcriptional regulator
HVY75_RS14120	COG0697	spore germination
HVY75_RS14190	COG0582	viral genome integration into host DNA
HVY75_RS14200	COG2211	Major facilitator Superfamily
HVY75_RS14205	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY75_RS14210	COG2982	Protein involved in outer membrane biogenesis
HVY75_RS14215	COG2233	PERMEase
HVY75_RS14220	COG0786	glutamate:sodium symporter activity
HVY75_RS14230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVY75_RS14235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY75_RS14240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY75_RS14250	COG0194	GDP metabolic process
HVY75_RS14260	COG2860	membrane
HVY75_RS14265	COG1561	YicC-like family, N-terminal region
HVY75_RS14295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVY75_RS14325	COG1519	Transferase
HVY75_RS14330	COG0859	PFAM glycosyl transferase family 9
HVY75_RS14335	COG0438	transferase activity, transferring glycosyl groups
HVY75_RS14340	COG0515	serine threonine protein kinase
HVY75_RS14345	COG4641	Protein conserved in bacteria
HVY75_RS14345	COG0438	transferase activity, transferring glycosyl groups
HVY75_RS14350	COG0438	transferase activity, transferring glycosyl groups
HVY75_RS14355	COG1442	glycosyl transferase family 8
HVY75_RS14360	COG1442	glycosyl transferase family 8
HVY75_RS14365	COG3642	lipopolysaccharide core region biosynthetic process
HVY75_RS14385	COG0859	PFAM glycosyl transferase family 9
HVY75_RS14390	COG0859	PFAM glycosyl transferase family 9
HVY75_RS14400	COG0156	8-amino-7-oxononanoate synthase activity
HVY75_RS14415	COG2204	response regulator
HVY75_RS14420	COG3852	Histidine kinase
HVY75_RS14425	COG0174	glutamine synthetase
HVY75_RS14435	COG0561	phosphatase activity
HVY75_RS14445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY75_RS14465	COG1011	Hydrolase
HVY75_RS14480	COG0456	acetyltransferase
HVY75_RS14500	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY75_RS14510	COG2864	formate dehydrogenase
HVY75_RS14515	COG0437	4 iron, 4 sulfur cluster binding
HVY75_RS14530	COG0326	Molecular chaperone. Has ATPase activity
HVY75_RS14550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS14550	COG3711	transcriptional antiterminator
HVY75_RS14555	COG1363	Peptidase, m42
HVY75_RS14560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS14560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS14565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS14575	COG1454	alcohol dehydrogenase
HVY75_RS14610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY75_RS14615	COG2258	MOSC domain
HVY75_RS14620	COG2205	protein histidine kinase activity
HVY75_RS14625	COG0745	RESPONSE REGULATOR receiver
HVY75_RS14630	COG3678	ATP-independent chaperone mediated protein folding
HVY75_RS14645	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVY75_RS14665	COG3152	Membrane
HVY75_RS14670	COG3691	Protein conserved in bacteria
HVY75_RS14675	COG0589	response to stress
HVY75_RS14685	COG1494	fructose-1,6-bisphosphatase
HVY75_RS14695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVY75_RS14710	COG1575	Belongs to the MenA family. Type 1 subfamily
HVY75_RS14725	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY75_RS14730	COG1609	Transcriptional regulator
HVY75_RS14735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVY75_RS14750	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVY75_RS14760	COG0626	cystathionine gamma-synthase activity
HVY75_RS14765	COG0527	aspartate kinase activity
HVY75_RS14765	COG0460	homoserine dehydrogenase
HVY75_RS14775	COG0737	Belongs to the 5'-nucleotidase family
HVY75_RS14780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVY75_RS14790	COG0697	spore germination
HVY75_RS14795	COG3738	Protein conserved in bacteria
HVY75_RS14800	COG0371	Dehydrogenase
HVY75_RS14805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY75_RS14810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS14810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS14810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY75_RS14815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS14820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS14825	COG1882	Formate acetyltransferase
HVY75_RS14830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY75_RS14835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS14840	COG2207	Transcriptional regulator
HVY75_RS14845	COG2194	sulfuric ester hydrolase activity
HVY75_RS14860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVY75_RS14875	COG0583	DNA-binding transcription factor activity
HVY75_RS14885	COG1473	amidohydrolase
HVY75_RS14890	COG0477	Major facilitator Superfamily
HVY75_RS14895	COG1309	transcriptional regulator
HVY75_RS14940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVY75_RS14945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVY75_RS14945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVY75_RS14980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY75_RS14985	COG0250	Participates in transcription elongation, termination and antitermination
HVY75_RS15020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVY75_RS15030	COG2104	thiamine diphosphate biosynthetic process
HVY75_RS15035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY75_RS15070	COG3068	Protein conserved in bacteria
HVY75_RS15085	COG3678	ATP-independent chaperone mediated protein folding
HVY75_RS15090	COG4191	Histidine kinase
HVY75_RS15095	COG2204	response regulator
HVY75_RS15100	COG0151	Belongs to the GarS family
HVY75_RS15130	COG0456	acetyltransferase
HVY75_RS15140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY75_RS15145	COG2224	Isocitrate lyase
HVY75_RS15160	COG1414	Transcriptional regulator
HVY75_RS15165	COG0646	methionine synthase
HVY75_RS15165	COG1410	methionine synthase
HVY75_RS15180	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVY75_RS15185	COG3122	Protein conserved in bacteria
HVY75_RS15225	COG1187	pseudouridine synthase activity
HVY75_RS15240	COG3541	Predicted nucleotidyltransferase
HVY75_RS15260	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY75_RS15355	COG0542	response to heat
HVY75_RS15360	COG0527	aspartate kinase activity
HVY75_RS15385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY75_RS15395	COG2814	Major facilitator Superfamily
HVY75_RS15395	COG0477	Major facilitator Superfamily
HVY75_RS15400	COG3833	ABC-type maltose transport systems, permease component
HVY75_RS15405	COG1175	transmembrane transport
HVY75_RS15410	COG2182	Extracellular solute-binding protein
HVY75_RS15415	COG3842	ATPase activity
HVY75_RS15445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVY75_RS15455	COG0534	Mate efflux family protein
HVY75_RS15460	COG3237	CsbD-like
HVY75_RS15465	COG0735	belongs to the Fur family
HVY75_RS15470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY75_RS15480	COG0604	alcohol dehydrogenase
HVY75_RS15485	COG0305	Participates in initiation and elongation during chromosome replication
HVY75_RS15495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY75_RS15510	COG1448	Aminotransferase
HVY75_RS15515	COG0567	Dehydrogenase, E1 component
HVY75_RS15525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY75_RS15530	COG0045	succinate-CoA ligase (ADP-forming) activity
HVY75_RS15535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY75_RS15540	COG0471	metal ion transport
HVY75_RS15545	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY75_RS15550	COG2204	response regulator
HVY75_RS15560	COG3700	Belongs to the class B bacterial acid phosphatase family
HVY75_RS15565	COG0432	Pfam Uncharacterised protein family UPF0047
HVY75_RS15570	COG2315	Protein conserved in bacteria
HVY75_RS15575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVY75_RS15580	COG0629	single-stranded DNA binding
HVY75_RS15595	COG0789	Transcriptional regulator
HVY75_RS15600	COG2252	PERMEase
HVY75_RS15605	COG0025	NhaP-type Na H and K H
HVY75_RS15610	COG2824	Alkylphosphonate utilization operon protein PhnA
HVY75_RS15615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVY75_RS15630	COG0642	Histidine kinase
HVY75_RS15635	COG0745	RESPONSE REGULATOR receiver
HVY75_RS15640	COG2194	sulfuric ester hydrolase activity
HVY75_RS15645	COG2207	Transcriptional regulator
HVY75_RS15650	COG3647	Membrane
HVY75_RS15655	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY75_RS15655	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY75_RS15660	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY75_RS15665	COG4565	transcriptional regulatory protein
HVY75_RS15670	COG3290	protein histidine kinase activity
HVY75_RS15690	COG0437	4 iron, 4 sulfur cluster binding
HVY75_RS15695	COG3302	dmso reductase anchor subunit
HVY75_RS15700	COG3381	protein complex oligomerization
HVY75_RS15720	COG1309	transcriptional regulator
HVY75_RS15725	COG4232	protein-disulfide reductase activity
HVY75_RS15735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY75_RS15740	COG1027	Aspartate ammonia-lyase
HVY75_RS15745	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVY75_RS15750	COG0531	amino acid
HVY75_RS15775	COG1509	lysine 2,3-aminomutase activity
HVY75_RS15785	COG5510	response to toxic substance
HVY75_RS15790	COG5510	response to toxic substance
HVY75_RS15795	COG2076	Multidrug Resistance protein
HVY75_RS15800	COG3040	lipid binding
HVY75_RS15805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY75_RS15820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY75_RS15825	COG1053	succinate dehydrogenase
HVY75_RS15835	COG0531	amino acid
HVY75_RS15850	COG3264	Mechanosensitive ion channel
HVY75_RS15850	COG1511	domain protein
HVY75_RS15870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY75_RS15895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVY75_RS15900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVY75_RS15900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVY75_RS15905	COG0802	atpase or kinase
HVY75_RS15910	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY75_RS15930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVY75_RS15935	COG0330	HflC and HflK could
HVY75_RS15940	COG0330	HflC and HflK could
HVY75_RS15945	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVY75_RS15960	COG0557	exoribonuclease II activity
HVY75_RS15965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY75_RS15970	COG3789	protein conserved in bacteria
HVY75_RS15975	COG1842	Phage shock protein A
HVY75_RS15985	COG3766	membrane
HVY75_RS15990	COG5463	Belongs to the UPF0441 family
HVY75_RS15995	COG0754	glutathionylspermidine amidase activity
HVY75_RS16000	COG1960	acyl-CoA dehydrogenase activity
HVY75_RS16010	COG3650	response to hydrogen peroxide
HVY75_RS16015	COG1073	alpha beta
HVY75_RS16030	COG3037	sugar-specific permease SgaT UlaA
HVY75_RS16035	COG3414	Phosphotransferase system galactitol-specific IIB component
HVY75_RS16075	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVY75_RS16085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY75_RS16095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY75_RS16100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY75_RS16105	COG4670	ketone body catabolic process
HVY75_RS16110	COG1024	Enoyl-CoA hydratase
HVY75_RS16125	COG1309	transcriptional regulator
HVY75_RS16130	COG3061	Opacity-associated protein A
HVY75_RS16135	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY75_RS16140	COG1113	amino acid transport
HVY75_RS16150	COG0697	spore germination
HVY75_RS16155	COG0702	epimerase
HVY75_RS16160	COG1733	regulation of RNA biosynthetic process
HVY75_RS16165	COG0737	Belongs to the 5'-nucleotidase family
HVY75_RS16170	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVY75_RS16175	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY75_RS16185	COG1253	flavin adenine dinucleotide binding
HVY75_RS16190	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVY75_RS16200	COG0698	ribose 5-phosphate isomerase
HVY75_RS16205	COG1737	Transcriptional regulator
HVY75_RS16210	COG1879	ABC-type sugar transport system periplasmic component
HVY75_RS16215	COG1129	ABC transporter
HVY75_RS16220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY75_RS16225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY75_RS16230	COG1940	carbohydrate kinase activity
HVY75_RS16235	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVY75_RS16245	COG1566	PFAM secretion protein HlyD family protein
HVY75_RS16250	COG1289	transmembrane transporter activity
HVY75_RS16265	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY75_RS16270	COG1301	dicarboxylic acid transport
HVY75_RS16275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY75_RS16280	COG3162	membrane
HVY75_RS16295	COG0729	surface antigen
HVY75_RS16300	COG2911	Protein conserved in bacteria
HVY75_RS16305	COG2105	PFAM AIG2 family protein
HVY75_RS16310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVY75_RS16315	COG1879	ABC-type sugar transport system periplasmic component
HVY75_RS16320	COG1129	ABC transporter
HVY75_RS16325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY75_RS16330	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY75_RS16340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVY75_RS16345	COG3028	Belongs to the UPF0307 family
HVY75_RS16350	COG0312	modulator of DNA gyrase
HVY75_RS16355	COG3783	Cytochrome b(562)
HVY75_RS16360	COG3077	Addiction module antitoxin, RelB DinJ family
HVY75_RS16365	COG2026	Addiction module toxin, RelE StbE family
HVY75_RS16370	COG0602	queuosine metabolic process
HVY75_RS16375	COG1328	CTP reductase activity
HVY75_RS16380	COG0366	Alpha amylase catalytic
HVY75_RS16385	COG1263	PTS System
HVY75_RS16385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY75_RS16390	COG1609	Transcriptional regulator
HVY75_RS16400	COG0251	oxidation-reduction process
HVY75_RS16420	COG1438	arginine binding
HVY75_RS16425	COG1288	antiporter activity
HVY75_RS16430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVY75_RS16435	COG0549	Belongs to the carbamate kinase family
HVY75_RS16445	COG2731	YhcH YjgK YiaL family protein
HVY75_RS16450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVY75_RS16455	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVY75_RS16460	COG0456	acetyltransferase
HVY75_RS16470	COG0525	valine-tRNA ligase activity
HVY75_RS16475	COG2927	DNA polymerase III (CHI subunit)
HVY75_RS16490	COG0795	lipopolysaccharide-transporting ATPase activity
HVY75_RS16495	COG0795	lipopolysaccharide-transporting ATPase activity
HVY75_RS16500	COG2823	Periplasmic or secreted lipoprotein
HVY75_RS16520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVY75_RS16525	COG0363	glucosamine-6-phosphate deaminase activity
HVY75_RS16530	COG3716	PTS system mannose fructose sorbose family IID component
HVY75_RS16535	COG3715	PTS system
HVY75_RS16540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY75_RS16550	COG2222	sugar isomerase
HVY75_RS16555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY75_RS16560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS16565	COG3716	PTS system mannose fructose sorbose family IID component
HVY75_RS16575	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY75_RS16585	COG1349	DNA-binding transcription factor activity
HVY75_RS16595	COG2002	toxin-antitoxin pair type II binding
HVY75_RS16600	COG2721	sulfolactate sulfo-lyase activity
HVY75_RS16610	COG2084	Dehydrogenase
HVY75_RS16620	COG1741	Belongs to the pirin family
HVY75_RS16625	COG0583	DNA-binding transcription factor activity
HVY75_RS16630	COG3152	Membrane
HVY75_RS16635	COG0435	Glutathione S-transferase
HVY75_RS16640	COG2259	Doxx family
HVY75_RS16650	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVY75_RS16655	COG4575	ribosome binding
HVY75_RS16660	COG1422	Protein of unknown function (DUF1090)
HVY75_RS16670	COG0586	Pfam SNARE associated Golgi protein
HVY75_RS16675	COG2186	Transcriptional regulator
HVY75_RS16680	COG2271	Major facilitator Superfamily
HVY75_RS16690	COG2721	sulfolactate sulfo-lyase activity
HVY75_RS16700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVY75_RS16705	COG0861	Integral membrane protein TerC family
HVY75_RS16710	COG0673	inositol 2-dehydrogenase activity
HVY75_RS16715	COG2949	membrane
HVY75_RS16720	COG1451	nucleotide metabolic process
HVY75_RS16745	COG1484	DNA-dependent DNA replication
HVY75_RS16760	COG2966	Psort location CytoplasmicMembrane, score
HVY75_RS16770	COG1917	Cupin 2, conserved barrel domain protein
HVY75_RS16770	COG2169	Transcriptional regulator
HVY75_RS16775	COG2197	response regulator
HVY75_RS16780	COG2197	response regulator
HVY75_RS16785	COG4114	ferric iron reductase
HVY75_RS16825	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVY75_RS16830	COG0456	acetyltransferase
HVY75_RS16835	COG1011	Hydrolase
HVY75_RS16845	COG2823	Periplasmic or secreted lipoprotein
HVY75_RS16855	COG4667	esterase of the alpha-beta hydrolase superfamily
HVY75_RS16860	COG0084	hydrolase, TatD family'
HVY75_RS16865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY75_RS16870	COG1328	CTP reductase activity
HVY75_RS16905	COG3726	membrane protein affecting hemolysin expression
HVY75_RS16910	COG0560	Phosphoserine phosphatase
HVY75_RS16915	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVY75_RS16920	COG3172	ATPase kinase involved in NAD metabolism
HVY75_RS16920	COG1056	cytidyltransferase-related domain
HVY75_RS16925	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HVY75_RS16935	COG0488	(ABC) transporter
HVY75_RS16940	COG0741	lytic transglycosylase activity
HVY75_RS16960	COG2207	Transcriptional regulator
HVY75_RS16960	COG3708	Transcriptional regulator
HVY75_RS16965	COG3045	CreA protein
HVY75_RS16975	COG2205	protein histidine kinase activity
HVY75_RS16980	COG4452	Inner membrane protein CreD
HVY75_RS16985	COG0745	RESPONSE REGULATOR receiver
HVY75_RS16995	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVY75_RS17005	COG0460	homoserine dehydrogenase
HVY75_RS17005	COG0527	aspartate kinase activity
HVY75_RS17015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVY75_RS17030	COG1115	amino acid carrier protein
HVY75_RS17040	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY75_RS17045	COG1584	GPR1 FUN34 yaaH family protein
HVY75_RS17070	COG0583	DNA-binding transcription factor activity
HVY75_RS17085	COG0196	riboflavin kinase activity
HVY75_RS17100	COG1047	Peptidyl-prolyl cis-trans
HVY75_RS17130	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HVY75_RS17135	COG0511	ligase activity, forming carbon-carbon bonds
HVY75_RS17135	COG5016	pyruvate
HVY75_RS17190	COG0505	Belongs to the CarA family
HVY75_RS17195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVY75_RS17245	COG0644	oxidoreductase
HVY75_RS17250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY75_RS17255	COG2271	Major facilitator Superfamily
HVY75_RS17270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVY75_RS17310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY75_RS17320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVY75_RS17325	COG0564	pseudouridine synthase activity
HVY75_RS17335	COG0417	DNA replication proofreading
HVY75_RS17340	COG0235	Class ii aldolase
HVY75_RS17360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY75_RS17370	COG3181	Tripartite tricarboxylate transporter family receptor
HVY75_RS17385	COG0586	Pfam SNARE associated Golgi protein
HVY75_RS17395	COG1178	ABC-type Fe3 transport system permease component
HVY75_RS17400	COG4143	(ABC) transporter
HVY75_RS17415	COG2814	Major facilitator Superfamily
HVY75_RS17420	COG2271	Major facilitator Superfamily
HVY75_RS17425	COG0583	DNA-binding transcription factor activity
HVY75_RS17435	COG0738	Major facilitator superfamily
HVY75_RS17480	COG0028	Belongs to the TPP enzyme family
HVY75_RS17485	COG0440	acetolactate synthase activity
HVY75_RS17495	COG1609	Transcriptional regulator
HVY75_RS17510	COG3116	cell division
HVY75_RS17515	COG0768	penicillin binding
HVY75_RS17520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY75_RS17525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVY75_RS17540	COG0772	Belongs to the SEDS family
HVY75_RS17555	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY75_RS17560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVY75_RS17565	COG0849	cell division
HVY75_RS17570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVY75_RS17590	COG0494	nUDIX hydrolase
HVY75_RS17605	COG0237	dephospho-CoA kinase activity
HVY75_RS17615	COG1459	type II secretion system
HVY75_RS17620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY75_RS17625	COG4969	Belongs to the N-Me-Phe pilin family
HVY75_RS17630	COG0157	Belongs to the NadC ModD family
HVY75_RS17635	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY75_RS17640	COG3725	Membrane protein required for beta-lactamase induction
HVY75_RS17645	COG1113	amino acid transport
HVY75_RS17650	COG2186	Transcriptional regulator
HVY75_RS17655	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVY75_RS17660	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY75_RS17665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY75_RS17670	COG3064	Membrane
HVY75_RS17675	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVY75_RS17700	COG2132	Multicopper oxidase
HVY75_RS17705	COG4993	Dehydrogenase
HVY75_RS17710	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVY75_RS17715	COG0288	reversible hydration of carbon dioxide
HVY75_RS17720	COG1131	(ABC) transporter
HVY75_RS17725	COG0842	Transport permease protein
HVY75_RS17730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS17735	COG0726	polysaccharide deacetylase
HVY75_RS17745	COG5464	transposase or invertase
HVY75_RS17760	COG3539	Fimbrial protein
HVY75_RS17765	COG3539	Fimbrial protein
HVY75_RS17770	COG3539	Fimbrial protein
HVY75_RS17775	COG3539	Fimbrial protein
HVY75_RS17780	COG3188	usher protein
HVY75_RS17785	COG3121	Chaperone
HVY75_RS17790	COG3539	Fimbrial protein
HVY75_RS17795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVY75_RS17800	COG0617	tRNA 3'-terminal CCA addition
HVY75_RS17810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY75_RS17820	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVY75_RS17825	COG1643	Atp-dependent helicase
HVY75_RS17830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVY75_RS17835	COG4774	siderophore transport
HVY75_RS17840	COG1120	ATPase activity
HVY75_RS17845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY75_RS17850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY75_RS17875	COG2860	membrane
HVY75_RS17880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY75_RS17895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY75_RS17900	COG3835	regulator
HVY75_RS17910	COG1408	metallophosphoesterase
HVY75_RS17925	COG0024	Methionine aminopeptidase
HVY75_RS17950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVY75_RS17955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVY75_RS17960	COG0575	Belongs to the CDS family
HVY75_RS17965	COG0750	zinc metalloprotease
HVY75_RS17975	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVY75_RS17980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVY75_RS18005	COG0587	DNA-directed DNA polymerase activity
HVY75_RS18020	COG0346	lactoylglutathione lyase activity
HVY75_RS18030	COG4568	rho-dependent transcription termination
HVY75_RS18040	COG4681	YaeQ
HVY75_RS18045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY75_RS18050	COG3015	lipoprotein NlpE involved in copper resistance
HVY75_RS18055	COG0791	NLP P60 protein
HVY75_RS18065	COG1720	tRNA m6t6A37 methyltransferase activity
HVY75_RS18075	COG1464	Belongs to the NlpA lipoprotein family
HVY75_RS18080	COG2011	ABC-type metal ion transport system permease component
HVY75_RS18090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY75_RS18125	COG0656	L-ascorbic acid biosynthetic process
HVY75_RS18130	COG0583	DNA-binding transcription factor activity
HVY75_RS18140	COG2226	methyltransferase
HVY75_RS18145	COG0741	lytic transglycosylase activity
HVY75_RS18145	COG1388	LysM domain
HVY75_RS18155	COG2226	methyltransferase
HVY75_RS18165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY75_RS18175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY75_RS18185	COG1960	acyl-CoA dehydrogenase activity
HVY75_RS18195	COG0121	glutamine amidotransferase
HVY75_RS18200	COG3034	peptidoglycan biosynthetic process
HVY75_RS18205	COG0791	NLP P60 protein
HVY75_RS18215	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY75_RS18235	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVY75_RS18240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVY75_RS18245	COG2166	iron-sulfur cluster assembly
HVY75_RS18250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVY75_RS18260	COG0583	DNA-binding transcription factor activity
HVY75_RS18265	COG2363	Small membrane protein
HVY75_RS18280	COG1760	l-serine dehydratase
HVY75_RS18285	COG0814	amino acid
HVY75_RS18290	COG1611	Belongs to the LOG family
HVY75_RS18305	COG3098	single-species biofilm formation
HVY75_RS18310	COG0564	pseudouridine synthase activity
HVY75_RS18315	COG0716	FMN binding
HVY75_RS18335	COG4948	Mandelate Racemase Muconate Lactonizing
HVY75_RS18340	COG4948	Mandelate Racemase Muconate Lactonizing
HVY75_RS18345	COG1929	Belongs to the glycerate kinase type-1 family
HVY75_RS18350	COG2205	protein histidine kinase activity
HVY75_RS18350	COG4999	Histidine kinase
HVY75_RS18350	COG3850	Histidine kinase
HVY75_RS18350	COG3437	response regulator, receiver
HVY75_RS18355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVY75_RS18360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY75_RS18365	COG3956	TIGRFAM MazG family protein
HVY75_RS18380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY75_RS18390	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY75_RS18400	COG0602	queuosine metabolic process
HVY75_RS18410	COG0720	synthase
HVY75_RS18435	COG1203	CRISPR-associated helicase, Cas3
HVY75_RS18450	COG1857	crispr-associated protein
HVY75_RS18465	COG1518	maintenance of DNA repeat elements
HVY75_RS18470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY75_RS18475	COG2234	aminopeptidase activity
HVY75_RS18530	COG4942	peptidase
HVY75_RS18530	COG1388	LysM domain
HVY75_RS18535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY75_RS18545	COG0163	prenyltransferase activity
HVY75_RS18550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY75_RS18560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY75_RS18595	COG1129	ABC transporter
HVY75_RS18600	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY75_RS18605	COG1879	ABC-type sugar transport system periplasmic component
HVY75_RS18610	COG1349	DNA-binding transcription factor activity
HVY75_RS18625	COG3604	Transcriptional regulator
HVY75_RS18630	COG0309	Hydrogenase expression formation protein (HypE)
HVY75_RS18635	COG0409	Hydrogenase expression formation protein
HVY75_RS18640	COG0298	carbon dioxide binding
HVY75_RS18645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVY75_RS18650	COG0375	protein maturation
HVY75_RS18660	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY75_RS18665	COG0651	ATP synthesis coupled electron transport
HVY75_RS18670	COG0650	Formate hydrogenlyase subunit 4
HVY75_RS18675	COG3261	NADH dehydrogenase
HVY75_RS18675	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY75_RS18680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY75_RS18685	COG3260	NADH ubiquinone oxidoreductase 20
HVY75_RS18695	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY75_RS18700	COG2723	6-phospho-beta-galactosidase activity
HVY75_RS18705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY75_RS18705	COG1263	PTS System
HVY75_RS18710	COG1609	Transcriptional regulator
HVY75_RS18715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY75_RS18720	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVY75_RS18740	COG0517	IMP dehydrogenase activity
HVY75_RS18740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY75_RS18750	COG2951	lytic endotransglycosylase activity
HVY75_RS18760	COG1546	Belongs to the CinA family
HVY75_RS18780	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVY75_RS18810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY75_RS18815	COG1238	metal cluster binding
HVY75_RS18840	COG2814	Major facilitator Superfamily
HVY75_RS18845	COG1566	PFAM secretion protein HlyD family protein
HVY75_RS18850	COG1846	Transcriptional regulator
HVY75_RS18860	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY75_RS18865	COG2814	Major facilitator Superfamily
HVY75_RS18870	COG2113	Glycine betaine
HVY75_RS18875	COG4176	ABC-type proline glycine betaine transport system permease component
HVY75_RS18880	COG4175	Glycine betaine
HVY75_RS18885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY75_RS18890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY75_RS18900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY75_RS18905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY75_RS18915	COG4575	ribosome binding
HVY75_RS18935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY75_RS18940	COG0640	Transcriptional regulator
HVY75_RS18945	COG0401	homolog of Blt101
HVY75_RS18950	COG1652	LysM domain
HVY75_RS18955	COG1802	Transcriptional regulator
HVY75_RS18960	COG1113	amino acid transport
HVY75_RS18965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY75_RS18970	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS18975	COG0579	oxidoreductase
HVY75_RS18985	COG0583	DNA-binding transcription factor activity
HVY75_RS18995	COG0666	response to abiotic stimulus
HVY75_RS19005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY75_RS19010	COG1304	FMN binding
HVY75_RS19015	COG0549	Belongs to the carbamate kinase family
HVY75_RS19020	COG0402	S-adenosylhomocysteine deaminase activity
HVY75_RS19025	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVY75_RS19035	COG1064	alcohol dehydrogenase
HVY75_RS19040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY75_RS19045	COG0698	ribose 5-phosphate isomerase
HVY75_RS19055	COG2376	Dihydroxyacetone kinase
HVY75_RS19060	COG0149	triose-phosphate isomerase activity
HVY75_RS19065	COG1082	Xylose isomerase domain protein TIM barrel
HVY75_RS19070	COG2084	Dehydrogenase
HVY75_RS19075	COG2390	Transcriptional regulator
HVY75_RS19080	COG0393	Putative heavy-metal-binding
HVY75_RS19100	COG2867	negative regulation of translational initiation
HVY75_RS19110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY75_RS19115	COG0497	DNA recombination
HVY75_RS19130	COG4536	flavin adenine dinucleotide binding
HVY75_RS19135	COG4137	Cytochrome C assembly protein
HVY75_RS19140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVY75_RS19170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY75_RS19175	COG0287	Prephenate dehydrogenase
HVY75_RS19175	COG1605	Chorismate mutase
HVY75_RS19180	COG0077	Prephenate dehydratase
HVY75_RS19180	COG1605	Chorismate mutase
HVY75_RS19190	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY75_RS19195	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY75_RS19200	COG0564	pseudouridine synthase activity
HVY75_RS19210	COG0542	response to heat
HVY75_RS19235	COG0477	Major facilitator Superfamily
HVY75_RS19240	COG5544	Lipoprotein
HVY75_RS19245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY75_RS19250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY75_RS19250	COG1042	CoA-binding domain protein
HVY75_RS19250	COG0045	succinate-CoA ligase (ADP-forming) activity
HVY75_RS19260	COG3118	belongs to the thioredoxin family
HVY75_RS19265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY75_RS19290	COG0513	Belongs to the DEAD box helicase family
HVY75_RS19300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY75_RS19310	COG1595	DNA-templated transcription, initiation
HVY75_RS19315	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVY75_RS19320	COG3026	antisigma factor binding
HVY75_RS19325	COG3086	response to oxidative stress
HVY75_RS19335	COG0681	Belongs to the peptidase S26 family
HVY75_RS19355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVY75_RS19370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY75_RS19375	COG1737	Transcriptional regulator
HVY75_RS19380	COG0560	Phosphoserine phosphatase
HVY75_RS19395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVY75_RS19395	COG0047	phosphoribosylformylglycinamidine synthase activity
HVY75_RS19400	COG2205	protein histidine kinase activity
HVY75_RS19405	COG3170	Tfp pilus assembly protein FimV
HVY75_RS19410	COG2204	response regulator
HVY75_RS19415	COG0347	Belongs to the P(II) protein family
HVY75_RS19435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY75_RS19440	COG4651	solute:proton antiporter activity
HVY75_RS19440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY75_RS19445	COG2223	nitrite transmembrane transporter activity
HVY75_RS19450	COG0737	Belongs to the 5'-nucleotidase family
HVY75_RS19465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY75_RS19470	COG3735	TraB family
HVY75_RS19475	COG3549	Plasmid maintenance system killer
HVY75_RS19480	COG3093	addiction module antidote protein HigA
HVY75_RS19485	COG2217	Heavy metal translocating P-type atpase
HVY75_RS19490	COG0531	amino acid
HVY75_RS19520	COG0789	Transcriptional regulator
HVY75_RS19525	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY75_RS19530	COG0330	HflC and HflK could
HVY75_RS19535	COG4619	ABC transporter
HVY75_RS19540	COG0390	transport system, permease component
HVY75_RS19545	COG3118	belongs to the thioredoxin family
HVY75_RS19550	COG0300	oxidoreductase activity
HVY75_RS19555	COG2755	lipolytic protein G-D-S-L family
HVY75_RS19560	COG4181	ATPase activity
HVY75_RS19565	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVY75_RS19570	COG3157	Type VI secretion system effector, Hcp
HVY75_RS19595	COG0583	DNA-binding transcription factor activity
HVY75_RS19605	COG1414	Transcriptional regulator
HVY75_RS19610	COG3960	tartronate-semialdehyde synthase activity
HVY75_RS19615	COG3622	Belongs to the hyi family
HVY75_RS19620	COG2084	Dehydrogenase
HVY75_RS19625	COG1953	Uracil, thiamine, allantoin
HVY75_RS19635	COG2233	PERMEase
HVY75_RS19640	COG1929	Belongs to the glycerate kinase type-1 family
HVY75_RS19645	COG3257	ureidoglycine aminohydrolase activity
HVY75_RS19650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY75_RS19655	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY75_RS19660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY75_RS19665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY75_RS19675	COG0549	Belongs to the carbamate kinase family
HVY75_RS19680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVY75_RS19685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVY75_RS19700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY75_RS19710	COG1988	membrane-bound metal-dependent
HVY75_RS19715	COG2501	S4 domain
HVY75_RS19745	COG1017	nitric oxide dioxygenase activity
HVY75_RS19745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY75_RS19755	COG2259	Doxx family
HVY75_RS19760	COG2814	Major facilitator Superfamily
HVY75_RS19765	COG3711	transcriptional antiterminator
HVY75_RS19770	COG1073	alpha beta
HVY75_RS19775	COG0483	inositol monophosphate 1-phosphatase activity
HVY75_RS19795	COG0822	iron-sulfur transferase activity
HVY75_RS19815	COG0633	Ferredoxin
HVY75_RS19820	COG2975	iron-sulfur cluster assembly
HVY75_RS19835	COG2897	thiosulfate sulfurtransferase activity
HVY75_RS19840	COG2373	Large extracellular alpha-helical protein
HVY75_RS19845	COG4953	penicillin-binding protein 1C
HVY75_RS19875	COG2976	Protein conserved in bacteria
HVY75_RS19890	COG1645	bacterial-type flagellum-dependent swarming motility
HVY75_RS19915	COG0516	GMP reductase activity
HVY75_RS19915	COG0517	IMP dehydrogenase activity
HVY75_RS19955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY75_RS20035	COG5484	DNA packaging
HVY75_RS20035	COG3728	DNA packaging
HVY75_RS20155	COG3179	chitinase
HVY75_RS20175	COG3133	Outer membrane lipoprotein
HVY75_RS20185	COG2200	EAL domain
HVY75_RS20190	COG0248	Ppx GppA phosphatase
HVY75_RS20200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVY75_RS20215	COG2233	PERMEase
HVY75_RS20225	COG1393	Belongs to the ArsC family
HVY75_RS20230	COG4783	chaperone-mediated protein folding
HVY75_RS20235	COG0628	permease
HVY75_RS20240	COG3604	Transcriptional regulator
HVY75_RS20250	COG3260	NADH ubiquinone oxidoreductase 20
HVY75_RS20255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY75_RS20260	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY75_RS20260	COG3261	NADH dehydrogenase
HVY75_RS20265	COG0651	ATP synthesis coupled electron transport
HVY75_RS20270	COG4237	Hydrogenase 4 membrane
HVY75_RS20275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY75_RS20280	COG0650	Formate hydrogenlyase subunit 4
HVY75_RS20285	COG0651	ATP synthesis coupled electron transport
HVY75_RS20290	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY75_RS20295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVY75_RS20300	COG2716	regulation of RNA biosynthetic process
HVY75_RS20310	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVY75_RS20330	COG2321	neutral zinc metallopeptidase
HVY75_RS20340	COG0400	carboxylic ester hydrolase activity
HVY75_RS20355	COG1393	Belongs to the ArsC family
HVY75_RS20365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY75_RS20370	COG3850	Histidine kinase
HVY75_RS20375	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY75_RS20375	COG0493	'glutamate synthase
HVY75_RS20385	COG5342	invasion associated locus B
HVY75_RS20390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY75_RS20395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY75_RS20400	COG0281	malic enzyme
HVY75_RS20400	COG0280	phosphate acetyltransferase
HVY75_RS20405	COG4810	utilization protein
HVY75_RS20410	COG4917	ethanolamine utilization protein
HVY75_RS20415	COG4766	ethanolamine catabolic process
HVY75_RS20420	COG4812	Cobalamin adenosyltransferase
HVY75_RS20425	COG0280	phosphate acetyltransferase
HVY75_RS20430	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVY75_RS20435	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HVY75_RS20440	COG1012	belongs to the aldehyde dehydrogenase family
HVY75_RS20445	COG4820	ethanolamine utilization protein (EutJ)
HVY75_RS20450	COG1454	alcohol dehydrogenase
HVY75_RS20455	COG3192	ethanolamine utilization protein
HVY75_RS20460	COG4819	ethanolamine utilization protein
HVY75_RS20465	COG4303	Ethanolamine ammonia lyase large subunit
HVY75_RS20475	COG4816	utilization protein
HVY75_RS20480	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVY75_RS20485	COG2207	Transcriptional regulator
HVY75_RS20505	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY75_RS20525	COG2837	iron assimilation
HVY75_RS20530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY75_RS20535	COG1263	PTS System
HVY75_RS20535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY75_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS20555	COG4150	thiosulfate binding
HVY75_RS20560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVY75_RS20565	COG4208	sulfate ABC transporter
HVY75_RS20570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVY75_RS20575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY75_RS20590	COG2190	(PTS) system
HVY75_RS20595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY75_RS20600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY75_RS20605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY75_RS20615	COG3115	cell septum assembly
HVY75_RS20625	COG3530	Putative quorum-sensing-regulated virulence factor
HVY75_RS20630	COG0385	Bile acid
HVY75_RS20640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVY75_RS20645	COG2211	Major facilitator Superfamily
HVY75_RS20655	COG0583	DNA-binding transcription factor activity
HVY75_RS20680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVY75_RS20685	COG3415	Transposase
HVY75_RS20690	COG3415	Transposase
HVY75_RS20705	COG2200	EAL domain
HVY75_RS20705	COG2199	diguanylate cyclase activity
HVY75_RS20710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY75_RS20735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS20740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY75_RS20745	COG0006	proline dipeptidase activity
HVY75_RS20750	COG1363	Peptidase, m42
HVY75_RS20760	COG2207	Transcriptional regulator
HVY75_RS20765	COG3279	Response regulator of the LytR AlgR family
HVY75_RS20770	COG3275	phosphorelay sensor kinase activity
HVY75_RS20775	COG0436	Aminotransferase
HVY75_RS20785	COG1560	Kdo2-lipid A biosynthetic process
HVY75_RS20805	COG0154	amidase activity
HVY75_RS20825	COG4638	Rieske (2fe-2S)
HVY75_RS20835	COG1028	Short-chain dehydrogenase reductase Sdr
HVY75_RS20845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY75_RS20855	COG0653	protein targeting
HVY75_RS20910	COG0582	viral genome integration into host DNA
HVY75_RS20920	COG2116	formate transmembrane transporter activity
HVY75_RS20930	COG2067	long-chain fatty acid transport protein
HVY75_RS20935	COG3691	Protein conserved in bacteria
HVY75_RS20950	COG2062	phosphohistidine phosphatase, SixA
HVY75_RS20955	COG3539	Fimbrial protein
HVY75_RS20960	COG3188	usher protein
HVY75_RS20965	COG3121	Chaperone
HVY75_RS20970	COG3539	Fimbrial protein
HVY75_RS20975	COG3539	Fimbrial protein
HVY75_RS20980	COG3539	Fimbrial protein
HVY75_RS21010	COG0730	response to heat
HVY75_RS21015	COG3101	peptidyl-lysine hydroxylation
HVY75_RS21030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY75_RS21050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY75_RS21060	COG0586	Pfam SNARE associated Golgi protein
HVY75_RS21070	COG0285	dihydrofolate synthase activity
HVY75_RS21075	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVY75_RS21080	COG1286	toxin biosynthetic process
HVY75_RS21085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVY75_RS21090	COG0163	prenyltransferase activity
HVY75_RS21095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY75_RS21100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY75_RS21105	COG4215	(ABC) transporter
HVY75_RS21110	COG4160	amino acid transport
HVY75_RS21115	COG4598	ABC transporter
HVY75_RS21120	COG5464	transposase or invertase
HVY75_RS21125	COG1090	epimerase
HVY75_RS21130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY75_RS21135	COG0625	glutathione transferase activity
HVY75_RS21140	COG0625	glutathione transferase activity
HVY75_RS21145	COG0622	Phosphoesterase
HVY75_RS21155	COG1609	Transcriptional regulator
HVY75_RS21170	COG3037	sugar-specific permease SgaT UlaA
HVY75_RS21175	COG3959	Transketolase, thiamine diphosphate binding domain
HVY75_RS21180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVY75_RS21185	COG0280	phosphate acetyltransferase
HVY75_RS21185	COG0857	belongs to the CobB CobQ family
HVY75_RS21190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVY75_RS21205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY75_RS21210	COG0471	metal ion transport
HVY75_RS21210	COG0490	domain, Protein
HVY75_RS21220	COG0436	Aminotransferase
HVY75_RS21225	COG0583	DNA-binding transcription factor activity
HVY75_RS21245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVY75_RS21250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVY75_RS21255	COG1034	ATP synthesis coupled electron transport
HVY75_RS21270	COG0839	Belongs to the complex I subunit 6 family
HVY75_RS21280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY75_RS21285	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY75_RS21310	COG2304	oxidoreductase activity
HVY75_RS21315	COG0835	chemotaxis
HVY75_RS21315	COG0784	Response regulator, receiver
HVY75_RS21325	COG2153	protein acetylation
HVY75_RS21330	COG4575	ribosome binding
HVY75_RS21335	COG1169	isochorismate synthase
HVY75_RS21350	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVY75_RS21360	COG0318	PFAM AMP-dependent synthetase and ligase
HVY75_RS21435	COG5464	transposase or invertase
HVY75_RS21440	COG0247	lactate metabolic process
HVY75_RS21450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY75_RS21455	COG2271	Major facilitator Superfamily
HVY75_RS21460	COG0584	glycerophosphoryl diester phosphodiesterase
HVY75_RS21465	COG3642	lipopolysaccharide core region biosynthetic process
HVY75_RS21470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY75_RS21475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY75_RS21480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY75_RS21485	COG3468	outer membrane autotransporter barrel domain protein
HVY75_RS21495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY75_RS21500	COG0183	Belongs to the thiolase family
HVY75_RS21505	COG2031	fatty acid transporter
HVY75_RS21510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY75_RS21515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVY75_RS21520	COG2204	response regulator
HVY75_RS21525	COG3852	Histidine kinase
HVY75_RS21530	COG2205	protein histidine kinase activity
HVY75_RS21530	COG0784	Response regulator, receiver
HVY75_RS21535	COG2197	response regulator
HVY75_RS21540	COG0642	Histidine kinase
HVY75_RS21540	COG2198	Histidine kinase
HVY75_RS21545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY75_RS21550	COG1477	protein flavinylation
HVY75_RS21555	COG2169	Transcriptional regulator
HVY75_RS21555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY75_RS21560	COG3145	DNA-N1-methyladenine dioxygenase activity
HVY75_RS21565	COG4615	Cyclic peptide transporter
HVY75_RS21575	COG1126	abc transporter atp-binding protein
HVY75_RS21580	COG0765	amino acid transport
HVY75_RS21585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY75_RS21595	COG5006	permease, DMT superfamily
HVY75_RS21600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVY75_RS21605	COG2194	sulfuric ester hydrolase activity
HVY75_RS21615	COG1321	iron dependent repressor
HVY75_RS21620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY75_RS21625	COG1376	ErfK ybiS ycfS ynhG family protein
HVY75_RS21630	COG0488	(ABC) transporter
HVY75_RS21635	COG0561	phosphatase activity
HVY75_RS21640	COG1882	Formate acetyltransferase
HVY75_RS21645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY75_RS21650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY75_RS21655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY75_RS21660	COG0303	'Molybdopterin
HVY75_RS21685	COG2200	EAL domain
HVY75_RS21690	COG2199	diguanylate cyclase activity
HVY75_RS21705	COG2133	pyrroloquinoline quinone binding
HVY75_RS21710	COG0625	glutathione transferase activity
HVY75_RS21715	COG1686	Belongs to the peptidase S11 family
HVY75_RS21720	COG1349	DNA-binding transcription factor activity
HVY75_RS21725	COG0671	phosphoesterase, PA-phosphatase related
HVY75_RS21730	COG2814	Major facilitator Superfamily
HVY75_RS21740	COG0561	phosphatase activity
HVY75_RS21745	COG0738	Major facilitator superfamily
HVY75_RS21750	COG3226	Transcriptional regulator
HVY75_RS21770	COG0778	Nitroreductase
HVY75_RS21785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY75_RS21790	COG3842	ATPase activity
HVY75_RS21795	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY75_RS21800	COG1177	transmembrane transport
HVY75_RS21815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY75_RS21820	COG4160	amino acid transport
HVY75_RS21825	COG4215	(ABC) transporter
HVY75_RS21830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY75_RS21835	COG1126	abc transporter atp-binding protein
HVY75_RS21850	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY75_RS21855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY75_RS21860	COG0702	epimerase
HVY75_RS21865	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVY75_RS21870	COG0028	Belongs to the TPP enzyme family
HVY75_RS21880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY75_RS21890	COG2431	L-lysine efflux transmembrane transporter activity
HVY75_RS21900	COG3593	DNA synthesis involved in DNA repair
HVY75_RS21905	COG2990	Protein conserved in bacteria
HVY75_RS21910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS21920	COG1278	Cold shock
HVY75_RS21930	COG0542	response to heat
HVY75_RS21950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVY75_RS21955	COG4988	ABC transporter
HVY75_RS21960	COG0492	ferredoxin-NADP+ reductase activity
HVY75_RS21965	COG1522	sequence-specific DNA binding
HVY75_RS21970	COG1178	ABC-type Fe3 transport system permease component
HVY75_RS21970	COG1674	ftsk spoiiie
HVY75_RS21980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVY75_RS21990	COG1335	isochorismatase
HVY75_RS22000	COG0531	amino acid
HVY75_RS22010	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY75_RS22015	COG4974	Belongs to the 'phage' integrase family
HVY75_RS22110	COG1192	Involved in chromosome partitioning
HVY75_RS22195	COG0210	DNA helicase
HVY75_RS22340	COG4245	von Willebrand factor, type A
HVY75_RS22345	COG4245	von Willebrand factor, type A
HVY75_RS22375	COG1358	cellular component organization or biogenesis
HVY75_RS22455	COG3550	peptidyl-serine autophosphorylation
HVY75_RS22490	COG0786	glutamate:sodium symporter activity
HVY75_RS22505	COG0640	Transcriptional regulator
HVY75_RS22650	COG4221	oxidoreductase activity
HVY75_RS22770	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY75_RS22800	COG0739	heme binding
HVY75_RS22810	COG2132	Multicopper oxidase
HVY75_RS22815	COG3667	copper resistance
HVY75_RS22820	COG2372	response to copper ion
HVY75_RS22825	COG1276	copper resistance
HVY75_RS22830	COG0745	RESPONSE REGULATOR receiver
HVY75_RS22835	COG2205	protein histidine kinase activity
HVY75_RS22920	COG0697	spore germination
HVY75_RS23030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HVY75_RS23030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY75_RS23050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY75_RS23210	COG3385	transposase activity
HVY75_RS23390	COG2026	Addiction module toxin, RelE StbE family