locus-tag class description HV012_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV012_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV012_RS00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HV012_RS00030 ENOG410667J hydrolase HV012_RS00035 ENOG410657R replicase EC 2.7 HV012_RS00040 ENOG4105EMF GntR family transcriptional regulator HV012_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HV012_RS00050 ENOG4108RTU Aldolase HV012_RS00060 ENOG4105DJB Major Facilitator Superfamily HV012_RS00070 ENOG4105D99 atp gtp-binding protein HV012_RS00075 ENOG4105R2A (LipO)protein HV012_RS00085 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HV012_RS00090 ENOG4105D0C transport protein HV012_RS00095 ENOG4105FDP GntR family transcriptional regulator HV012_RS00100 ENOG4105CI1 PTS System HV012_RS00105 ENOG4105F8D glycoside hydrolase family 4 HV012_RS00115 ENOG4105VG5 Membrane HV012_RS00120 ENOG4105JP4 Inner membrane protein yidG HV012_RS00125 ENOG4105J13 transcriptional regulator HV012_RS00140 ENOG4105W8I Transcriptional regulator HV012_RS00145 ENOG4105E5M Multidrug resistance protein D HV012_RS00160 ENOG4105C7K acetolactate synthase HV012_RS00165 ENOG4105M71 acetolactate synthase 1 regulatory subunit HV012_RS00170 ENOG4108KX4 response regulator HV012_RS00175 ENOG4105BZU Histidine kinase HV012_RS00180 ENOG4105CXY transporter HV012_RS00185 ENOG4105CXY transporter HV012_RS00190 ENOG4108SAJ Protein of unknown function (DUF1198) HV012_RS00200 ENOG4105VCP PTS System HV012_RS00205 ENOG4105CS2 ec 3.2.1.21 HV012_RS00210 ENOG4105CK1 PTS System HV012_RS00220 ENOG4105ETE Transcriptional regulator (LacI family HV012_RS00225 ENOG4105T8A Uncharacterized protein YicS HV012_RS00230 ENOG4108UZ3 Transporter HV012_RS00250 ENOG4105CT4 transporter HV012_RS00255 ENOG4105CJQ hydrolase, family 31 HV012_RS00260 ENOG4105JV1 AsmA family HV012_RS00265 ENOG4105C2W permease HV012_RS00270 ENOG4105D6U Sodium Glutamate Symporter HV012_RS00280 ENOG4105CB5 ATP-dependent DNA helicase recG HV012_RS00285 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HV012_RS00290 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV012_RS00300 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HV012_RS00310 ENOG4105EN6 Membrane HV012_RS00430 ENOG4105DSJ YicC domain protein HV012_RS00455 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HV012_RS00460 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HV012_RS00470 ENOG4105KDC 50s ribosomal protein l28 HV012_RS00490 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HV012_RS00495 ENOG4105DKP glycosyl transferase, family 9 HV012_RS00500 ENOG4107RJ7 Glycosyl transferase (Group 1 HV012_RS00505 ENOG4107543 (lipo)polysaccharide HV012_RS00510 ENOG4108XNZ glycosyl transferase HV012_RS00515 ENOG4107XU6 Glycosyl transferase (Group 1 HV012_RS00520 ENOG4106AH0 Glycosyl Transferase HV012_RS00525 ENOG4105X1N Glycosyl transferase family 8 HV012_RS00530 ENOG4108PDR lipopolysaccharide core biosynthesis protein HV012_RS00535 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HV012_RS00540 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HV012_RS00545 ENOG4108FRV O-antigen ligase HV012_RS00550 ENOG4105D16 lipopolysaccharide heptosyltransferase i HV012_RS00555 ENOG4105XA0 heptosyltransferase ii HV012_RS00565 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV012_RS00575 ENOG4106FIY HV012_RS00580 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV012_RS00585 ENOG4105CUX Signal transduction histidine kinase HV012_RS00590 ENOG4105C5F glutamine synthetase HV012_RS00595 ENOG4105CI3 gtp-binding protein typa HV012_RS00600 ENOG4108K85 Transcriptional regulator HV012_RS00605 ENOG4108KHF Resistance protein HV012_RS00610 ENOG4105R9B Major Facilitator HV012_RS00615 ENOG4105E98 transcriptional regulator DeoR family HV012_RS00620 ENOG4108MGF sugar kinase HV012_RS00625 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV012_RS00630 ENOG4105D2M Aldolase HV012_RS00635 ENOG4105CPQ Dehydrogenase HV012_RS00645 ENOG4105CSH Transporter HV012_RS00655 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HV012_RS00670 ENOG4105SUU thioesterase domain HV012_RS00700 ENOG41068KX affects formate dehydrogenase-N HV012_RS00710 ENOG4108MG3 formate dehydrogenase HV012_RS00715 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV012_RS00730 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HV012_RS00740 ENOG4106C3V frv operon regulatory protein HV012_RS00745 ENOG4105CN9 Peptidase m42 family protein HV012_RS00750 ENOG4105DM4 PTS System HV012_RS00755 ENOG41064BA PTS system, fructose-specific, IIA component HV012_RS00800 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV012_RS00805 ENOG4108RPX mosc domain containing protein HV012_RS00810 ENOG4105E0F Histidine kinase HV012_RS00815 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV012_RS00820 ENOG4105FMW periplasmic HV012_RS00835 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HV012_RS00850 ENOG4105EBK exported protein HV012_RS00855 ENOG4108VTS Membrane HV012_RS00860 ENOG41065TG regulatoR HV012_RS00870 ENOG4105DP0 ferredoxin-NADP reductase HV012_RS00875 ENOG4105CBT Fructose-1,6-bisphosphatase HV012_RS00885 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV012_RS00900 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HV012_RS00915 ENOG41063M6 Cell Division Protein HV012_RS00920 ENOG4105ETE Transcriptional regulator (LacI family HV012_RS00925 ENOG4105C25 Primosomal protein n' HV012_RS00940 ENOG4107S01 Repressor protein MetJ HV012_RS00950 ENOG4105C28 cystathionine HV012_RS00955 ENOG4105CFH Aspartokinase HV012_RS00965 ENOG4105CGH 5'-nucleotidase HV012_RS00970 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HV012_RS00975 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV012_RS00990 ENOG4105SYT Methylenetetrahydrofolate reductase HV012_RS01000 ENOG4108Q5Y Membrane HV012_RS01005 ENOG4108XC3 NADH ubiquinone oxidoreductase HV012_RS01010 ENOG4105DCT glycerol dehydrogenase HV012_RS01015 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV012_RS01020 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV012_RS01025 ENOG4105DM4 PTS System HV012_RS01030 ENOG4108YRF PTS System HV012_RS01040 ENOG4108AHH pyruvate formate lyase II activase HV012_RS01045 ENOG4108XCZ PTS System HV012_RS01050 ENOG4106R3P AraC family transcriptional regulator HV012_RS01055 ENOG4105DIJ Phosphoethanolamine transferase HV012_RS01070 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HV012_RS01085 ENOG4105C5Q Transcriptional regulator HV012_RS01095 ENOG4105CH2 amidohydrolase HV012_RS01105 ENOG4105EJ2 Transcriptional regulator HV012_RS01110 ENOG4108Y73 Membrane HV012_RS01155 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HV012_RS01190 ENOG4105PM1 preprotein translocase subunit SecE HV012_RS01195 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HV012_RS01230 ENOG4105D41 biosynthesis protein thiH HV012_RS01240 ENOG4105WHD thiamine biosynthesis protein ThiS HV012_RS01245 ENOG4105D06 uba thif-type nad fad binding protein HV012_RS01280 ENOG4105R2J Conserved Protein HV012_RS01290 ENOG4108T8B Protein of unknown function (DUF1481) HV012_RS01295 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HV012_RS01300 ENOG4105BZU Histidine kinase HV012_RS01305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV012_RS01310 ENOG4105C12 Phosphoribosylglycinamide synthetase HV012_RS01340 ENOG4105K5X acetyltransferase HV012_RS01350 ENOG4107QP3 malate synthase g HV012_RS01355 ENOG4108I9X Isocitrate lyase HV012_RS01370 ENOG41069M3 Transcriptional regulator HV012_RS01375 ENOG4105C3R Methionine synthase HV012_RS01390 ENOG4105EAM Na Pi-cotransporter HV012_RS01395 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HV012_RS01400 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV012_RS01405 ENOG4105F3R pts system mannose fructose sorbose family iid HV012_RS01410 ENOG4105ETZ PTS System HV012_RS01415 ENOG4105KPI PTS system sorbose subfamily IIB component HV012_RS01420 ENOG4108XCU pts system HV012_RS01425 ENOG4105CHR reductase HV012_RS01430 ENOG4105DKT Transcriptional regulator HV012_RS01435 ENOG4105FE9 pseudouridine synthase HV012_RS01440 ENOG4108ZR5 Conserved Protein HV012_RS01450 ENOG410756H nucleotidyltransferase HV012_RS01455 ENOG4108WZA zeta toxin HV012_RS01460 ENOG4105CFH Aspartokinase HV012_RS01465 ENOG4107QP8 phosphohexose isomerase HV012_RS01475 ENOG4108MDC (LipO)protein HV012_RS01480 ENOG4108Q9C Periplasmic Protein HV012_RS01485 ENOG4105E3R (LipO)protein HV012_RS01500 ENOG4107QNK )-transporter HV012_RS01505 ENOG4105EG2 ABC transporter, permease HV012_RS01510 ENOG4105D56 permease protein HV012_RS01515 ENOG4107FKK extracellular solute-binding protein family 1 HV012_RS01520 ENOG4108IJ9 (ABC) transporter HV012_RS01530 ENOG4107W52 maltose operon periplasmic protein HV012_RS01550 ENOG41080IJ Diacylglycerol kinase HV012_RS01560 ENOG4107R73 Mate efflux family protein HV012_RS01565 ENOG4105VDW Csbd family HV012_RS01570 ENOG4105MYN Zinc uptake regulation protein HV012_RS01605 ENOG41077V0 CPS-53 (KpLE1) prophage HV012_RS01610 ENOG4108R7K Metal Dependent Phosphohydrolase HV012_RS01615 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HV012_RS01620 ENOG4105H40 HV012_RS01630 ENOG4108XTP Transcriptional regulator HV012_RS01640 ENOG4108S1U HV012_RS01670 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HV012_RS01680 ENOG4108MXB Protein of unknown function (DUF968) HV012_RS01685 ENOG4105HRS Antitermination protein HV012_RS01705 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HV012_RS01710 ENOG4105KUS lysozyme HV012_RS01715 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV012_RS01745 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HV012_RS01830 ENOG4108X9F tail fiber protein HV012_RS01850 ENOG4106FE3 DNA repair HV012_RS01860 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV012_RS01865 ENOG4105P4Z Phage shock protein G HV012_RS01870 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HV012_RS01875 ENOG4105CDU Replicative dna helicase HV012_RS01890 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV012_RS01895 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV012_RS01900 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV012_RS01905 ENOG4105CGF Aromatic amino acid aminotransferase HV012_RS01910 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV012_RS01915 ENOG4105C7S Dehydrogenase HV012_RS01920 ENOG4107QN2 dihydrolipoyl dehydrogenase HV012_RS01925 ENOG4105CMV Succinyl-CoA synthetase subunit beta HV012_RS01930 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV012_RS01935 ENOG4107QPK )-transporter HV012_RS01940 ENOG4105DG4 malate L-lactate dehydrogenase HV012_RS01945 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV012_RS01950 ENOG4105CQZ Histidine kinase HV012_RS01955 ENOG4105F0S class B acid phosphatase HV012_RS01960 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HV012_RS01965 ENOG4105MSB protein, conserved in bacteria HV012_RS01970 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV012_RS01975 ENOG4108UUM single-stranded DNA-binding protein HV012_RS01980 ENOG4105PMV Membrane HV012_RS01985 ENOG4108W3Q Transcriptional regulator HV012_RS01990 ENOG4108Z4X TRANSCRIPTIONal HV012_RS01995 ENOG4105C7N Xanthine uracil vitamin C permease HV012_RS02000 ENOG4105EEQ Na H antiporter HV012_RS02005 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HV012_RS02010 ENOG4108F5E vimentin HV012_RS02015 ENOG4108YIV HV012_RS02020 ENOG4105CSH Transporter HV012_RS02025 ENOG4105ECM Sensor protein basS pmrB HV012_RS02030 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV012_RS02035 ENOG4105DIJ Phosphoethanolamine transferase HV012_RS02040 ENOG4106ZGR Transcriptional regulator HV012_RS02045 ENOG4108R5S membrane HV012_RS02050 ENOG4107GFK fumarate HV012_RS02055 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV012_RS02060 ENOG4108MRH transcriptional regulatory protein HV012_RS02065 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV012_RS02070 ENOG4107QY8 reductase HV012_RS02075 ENOG4105QAX Iron-sulfur HV012_RS02080 ENOG4107KGK dmso reductase anchor subunit HV012_RS02085 ENOG4108NEM leader-binding protein dmsD HV012_RS02105 ENOG4108SIC Transcriptional regulator HV012_RS02110 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HV012_RS02120 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV012_RS02125 ENOG4108IJ0 Aspartate ammonia-lyase HV012_RS02130 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HV012_RS02135 ENOG4105DVH amino acid HV012_RS02150 ENOG4108ZVF (LipO)protein HV012_RS02160 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HV012_RS02170 ENOG4107PEH Entericidin EcnA/B family HV012_RS02175 ENOG4106BSU Entericidin B HV012_RS02180 ENOG4105KPY Small multidrug resistance protein HV012_RS02185 ENOG4105QNF Outer membrane lipoprotein HV012_RS02190 ENOG41066YJ Beta-lactamase HV012_RS02205 ENOG4105E33 succinate dehydrogenase HV012_RS02210 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV012_RS02220 ENOG4107SC7 Inner membrane transporter yjeM HV012_RS02225 ENOG4105EGS Mechanosensitive ion channel HV012_RS02245 ENOG4106TNF Periplasmic binding protein HV012_RS02270 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HV012_RS02275 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HV012_RS02280 ENOG4105K8N protein family UPF0079, ATPase HV012_RS02285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV012_RS02305 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HV012_RS02310 ENOG4107QJR hflk protein HV012_RS02315 ENOG4105EPW hflc protein HV012_RS02335 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HV012_RS02340 ENOG4105C2N RNA methyltransferase TrmH family group 3 HV012_RS02345 ENOG4105FUX Conserved Protein HV012_RS02350 ENOG4108P9J Phage shock protein A HV012_RS02355 ENOG4107VNS Protein of unknown function (DUF2491) HV012_RS02360 ENOG4105Z6B inner membrane protein yjfl HV012_RS02365 ENOG4108KXT Conserved Protein HV012_RS02370 ENOG4106032 Glutathionylspermidine synthase HV012_RS02375 ENOG4105CSU acyl-Coa dehydrogenase HV012_RS02380 ENOG4105S17 UPF0379 protein yjfN HV012_RS02385 ENOG4105WSB biofilm stress and motility protein A HV012_RS02390 ENOG4108MXZ Esterase HV012_RS02395 ENOG4105DW5 Transcriptional regulator HV012_RS02405 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HV012_RS02435 ENOG4105KIT UPF0379 protein yjfY HV012_RS02450 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HV012_RS02460 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV012_RS02465 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV012_RS02470 ENOG41069H7 transport system small permease component HV012_RS02475 ENOG4107S3R L-aspartate oxidase HV012_RS02480 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HV012_RS02485 ENOG4105E39 Enoyl-CoA hydratase HV012_RS02495 ENOG4105CHR reductase HV012_RS02510 ENOG4105FHY Opacity-associated protein A HV012_RS02515 ENOG4108V1T peptidylprolyl cis-trans isomerase HV012_RS02530 ENOG4105DXC membrane HV012_RS02535 ENOG4105ECR NmrA family HV012_RS02540 ENOG4105KVH Transcriptional regulator HV012_RS02545 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HV012_RS02550 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HV012_RS02555 ENOG4108UUE Transcriptional regulator HV012_RS02560 ENOG41061GZ Protein of unknown function (DUF1107) HV012_RS02565 ENOG4105C37 (CBS) domain HV012_RS02570 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HV012_RS02580 ENOG4108YZG isomerase HV012_RS02585 ENOG4105NYY transcriptional regulator, RpiR HV012_RS02590 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV012_RS02595 ENOG4105C2J ABC transporter HV012_RS02600 ENOG4105CNN ABC, transporter HV012_RS02605 ENOG4105UP7 3-epimerase HV012_RS02610 ENOG4107TFG D-allose kinase HV012_RS02635 ENOG4105J12 Multidrug resistance protein mdtN HV012_RS02640 ENOG4108MI0 Resistance protein HV012_RS02645 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV012_RS02655 ENOG41082ND Uncharacterized protein yjcO HV012_RS02660 ENOG4105CK2 sodium dicarboxylate symporter HV012_RS02665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV012_RS02670 ENOG41062QD Membrane HV012_RS02685 ENOG4105CFU surface antigen HV012_RS02690 ENOG4105MA0 exported protein HV012_RS02695 ENOG4108ZHD aig2 family HV012_RS02700 ENOG4105F0N pyrophosphate phospho-hydrolase HV012_RS02705 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HV012_RS02710 ENOG4105C2J ABC transporter HV012_RS02715 ENOG4107R9N ABC transporter HV012_RS02720 ENOG41062B0 ABC transporter, permease HV012_RS02730 ENOG4105DFU Cell wall formation (By similarity) HV012_RS02740 ENOG4105CMS peptidase U62, modulator of DNA gyrase HV012_RS02745 ENOG4108XVM Cytochrome b(562) HV012_RS02750 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HV012_RS02755 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HV012_RS02760 ENOG4105CG3 alpha amylase, catalytic region HV012_RS02765 ENOG4105C5Y PTS System HV012_RS02770 ENOG4105D4X repressor HV012_RS02780 ENOG4105KME endoribonuclease L-psp HV012_RS02795 ENOG4107C93 pyrBI operon leader peptide HV012_RS02805 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV012_RS02810 ENOG4105DBV ornithine carbamoyltransferase HV012_RS02825 ENOG4105XEP YhcH YjgK YiaL family protein HV012_RS02830 ENOG4105DBV ornithine carbamoyltransferase HV012_RS02835 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HV012_RS02840 ENOG4108MJ3 acetyltransferase HV012_RS02845 ENOG4108M3P Membrane HV012_RS02850 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HV012_RS02855 ENOG4105MYG DNA polymerase iii, chi subunit HV012_RS02865 ENOG4108M8S permease YjgP YjgQ family protein HV012_RS02870 ENOG4108K5H permease YjgP YjgQ family protein HV012_RS02875 ENOG4105W4M Transport-associated protein HV012_RS02890 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HV012_RS02895 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HV012_RS02900 ENOG4106HBN Galactosamine-6-phosphate isomerase HV012_RS02905 ENOG4105F3R pts system mannose fructose sorbose family iid HV012_RS02910 ENOG4105ETZ PTS System HV012_RS02915 ENOG4108UZY PTS System HV012_RS02925 ENOG4105E70 isomerase HV012_RS02930 ENOG4105CE4 GlcNAc 6-P deacetylase HV012_RS02935 ENOG4108YTN IIa component HV012_RS02940 ENOG4105F3R pts system mannose fructose sorbose family iid HV012_RS02950 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HV012_RS02960 ENOG4105E98 transcriptional regulator DeoR family HV012_RS02965 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HV012_RS02970 ENOG4105ZEG Suppressor protein HV012_RS02975 ENOG4105CTX dehydratase HV012_RS02985 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV012_RS03000 ENOG4108CNN domain protein HV012_RS03005 ENOG4105CWB LysR family transcriptional Regulator HV012_RS03010 ENOG4105KAF membrAne HV012_RS03015 ENOG4105CHF Glutathione S-transferase HV012_RS03020 ENOG4108VBZ doxx family HV012_RS03025 ENOG4105YJD HV012_RS03030 ENOG41090KG Inner membrane protein YqjE HV012_RS03035 ENOG4105NE1 Conserved Protein HV012_RS03040 ENOG4105WAY exported protein HV012_RS03050 ENOG4106W5V Membrane HV012_RS03055 ENOG4107YCY Transcriptional regulator HV012_RS03060 ENOG4105DPW Major facilitator superfamily MFS_1 HV012_RS03070 ENOG4105CTX dehydratase HV012_RS03075 ENOG4105P66 Membrane HV012_RS03080 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HV012_RS03085 ENOG4105DU1 integral membrane protein, terc HV012_RS03090 ENOG4105EE0 oxidoreductase HV012_RS03095 ENOG4108UB4 uncharacterized protein ygjQ HV012_RS03100 ENOG4108VKG metal-dependent hydrolase HV012_RS03120 ENOG4105RI1 glycoprotein receptor HV012_RS03125 ENOG4106CVF DNA replication protein HV012_RS03130 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HV012_RS03135 ENOG4107XM3 UPF0442 protein HV012_RS03140 ENOG4105DWK Membrane HV012_RS03145 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HV012_RS03150 ENOG4105EZV Transcriptional regulator HV012_RS03155 ENOG4108N8T regulatoR HV012_RS03160 ENOG4108T94 DNA-binding transcriptional activator BglJ HV012_RS03170 ENOG4108819 ferric iron reductase HV012_RS03175 ENOG4105YBH Protein of unknown function (DUF1435) HV012_RS03195 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV012_RS03200 ENOG4108WPU DNA polymerase III subunit psi HV012_RS03205 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV012_RS03210 ENOG4105PAD Hydrolase HV012_RS03230 ENOG4108R7K Metal Dependent Phosphohydrolase HV012_RS03235 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HV012_RS03240 ENOG4105H40 HV012_RS03260 ENOG4105RDA repressor HV012_RS03265 ENOG41078CG DNA-binding transcriptional regulator HV012_RS03270 ENOG4108S1U HV012_RS03290 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HV012_RS03300 ENOG4108MXB Protein of unknown function (DUF968) HV012_RS03305 ENOG4105HGD Antitermination protein HV012_RS03320 ENOG4105VEQ Cold shock protein HV012_RS03325 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HV012_RS03345 ENOG4108YV9 Protein of unknown function (DUF2514) HV012_RS03350 ENOG4105VEQ Cold shock protein HV012_RS03360 ENOG4106IAW HV012_RS03365 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV012_RS03395 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HV012_RS03475 ENOG410685N tail fiber protein HV012_RS03480 ENOG4105UZW Tail fiber assembly protein HV012_RS03485 ENOG4105MN3 Resolvase HV012_RS03490 ENOG4105W3V DNA-binding, transcriptional regulator HV012_RS03500 ENOG4106FE3 DNA repair HV012_RS03510 ENOG4105K3G Periplasmic Protein HV012_RS03520 ENOG4108NRW Phospholipase, patatin family HV012_RS03525 ENOG4105EYA deoxyribonuclease HV012_RS03530 ENOG41076CZ activating enzyme HV012_RS03535 ENOG4105G0K glycine radical enzyme YjjI family HV012_RS03540 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HV012_RS03560 ENOG4105EUP HipA domain protein HV012_RS03570 ENOG41062Z9 Membrane HV012_RS03575 ENOG4105EAC phosphoserine phosphatase HV012_RS03580 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HV012_RS03585 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV012_RS03590 ENOG4105C5H ABC transporter HV012_RS03595 ENOG4107SC1 transglycosylase HV012_RS03605 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV012_RS03615 ENOG4105UEI Transcriptional Regulator AraC Family HV012_RS03620 ENOG4108RH0 Crea protein HV012_RS03625 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV012_RS03630 ENOG4105EB3 Histidine kinase HV012_RS03635 ENOG4105CT7 inner membrane cred family protein HV012_RS03640 ENOG41065U4 response regulator HV012_RS03645 ENOG410759A HV012_RS03650 ENOG4106FVC RNA methyltransferase HV012_RS03660 ENOG4105CFH Aspartokinase HV012_RS03670 ENOG4105D98 threonine synthase HV012_RS03675 ENOG41062C6 Protein of unknown function (DUF2502) HV012_RS03685 ENOG4105BZG amino acid carrier protein HV012_RS03695 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV012_RS03700 ENOG4106HK8 GPR1 FUN34 yaaH family protein HV012_RS03715 ENOG4105WI6 cell killing protein encoded within cryptic prophage HV012_RS03725 ENOG41063Z6 transcriptional regulator, lysR family HV012_RS03735 ENOG410647N response to DNA damage stimulus HV012_RS03740 ENOG4105DTN riboflavin biosynthesis protein ribF HV012_RS03745 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HV012_RS03755 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HV012_RS03775 ENOG4106YYS transcriptional regulatory protein HV012_RS03780 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV012_RS03785 ENOG4105D9Q decarboxylase (Beta subunit) HV012_RS03790 ENOG4107QSA Oxaloacetate decarboxylase HV012_RS03800 ENOG4105D2K citrate carrier protein HV012_RS03805 ENOG4105DUA (citrate (pro-3S)-lyase ligase HV012_RS03815 ENOG4105CI0 Citrate lyase HV012_RS03820 ENOG4105CHY citrate lyase, alpha HV012_RS03845 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HV012_RS03850 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV012_RS03855 ENOG4108XNW Transcriptional activatory protein CaiF HV012_RS03865 ENOG4106YT9 Enoyl-CoA hydratase HV012_RS03895 ENOG4105C10 Electron transfer flavoprotein HV012_RS03900 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV012_RS03905 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HV012_RS03910 ENOG4105C54 Major Facilitator superfamily HV012_RS03925 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HV012_RS03960 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HV012_RS03970 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HV012_RS03975 ENOG4105D3G Pseudouridine synthase HV012_RS03980 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HV012_RS03985 ENOG4105CQ2 DNA polymerase HV012_RS03990 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV012_RS04035 ENOG4108KF1 Membrane HV012_RS04045 ENOG4106SMU thiamine transporter membrane protein HV012_RS04050 ENOG4105DP9 ABC transporter HV012_RS04055 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HV012_RS04065 ENOG4105S8Q sugar efflux transporter HV012_RS04070 ENOG4105DJB Major Facilitator Superfamily HV012_RS04075 ENOG4105DND Transcriptional regulator HV012_RS04080 ENOG4105FF2 Type I DHQase HV012_RS04085 ENOG4105EMV Major Facilitator HV012_RS04100 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV012_RS04125 ENOG41064T2 transcriptional regulator, lysR family HV012_RS04130 ENOG4105C7K acetolactate synthase HV012_RS04135 ENOG4108ZP8 Acetolactate synthase small subunit HV012_RS04145 ENOG4107B7Y DNA-binding transcriptional regulator FruR HV012_RS04160 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV012_RS04165 ENOG4105CJN penicillin-binding protein HV012_RS04170 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HV012_RS04175 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HV012_RS04185 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HV012_RS04190 ENOG4105CNI cell division protein FtsW HV012_RS04205 ENOG4105CPF Cell wall formation (By similarity) HV012_RS04210 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HV012_RS04215 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HV012_RS04220 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HV012_RS04240 ENOG4105M6F mutator MutT protein HV012_RS04255 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HV012_RS04265 ENOG4105D7Q type ii secretion system HV012_RS04270 ENOG4107QHF type ii secretion system protein e HV012_RS04275 ENOG4108ZUW Major pilin subunit HV012_RS04280 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV012_RS04285 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV012_RS04290 ENOG4106A72 regulatory protein AmpE HV012_RS04295 ENOG4105C85 amino acid HV012_RS04300 ENOG41073TP transcriptional regulator HV012_RS04305 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HV012_RS04310 ENOG4107QSN dihydrolipoamide acetyltransferase HV012_RS04315 ENOG4107QN2 dihydrolipoyl dehydrogenase HV012_RS04320 ENOG4108NST exported protein HV012_RS04325 ENOG4107QIJ Aconitate hydratase 2 HV012_RS04345 ENOG4108ZRK uncharacterized protein yacC HV012_RS04350 ENOG4105E3B Multicopper oxidase HV012_RS04355 ENOG4105DZG Dehydrogenase HV012_RS04360 ENOG4108UGV hypoxanthine phosphoribosyltransferase HV012_RS04365 ENOG41077A9 carbonic anhydrase HV012_RS04370 ENOG4105DA5 (ABC) transporter HV012_RS04375 ENOG4105E3A (ABC) transporter HV012_RS04380 ENOG4108YTN IIa component HV012_RS04385 ENOG4107BJW polysaccharide deacetylase HV012_RS04395 ENOG4108A32 Transposase HV012_RS04410 ENOG4105P0Q fimbrial-like protein YadC HV012_RS04415 ENOG4105SN2 fimbrial-like adhesin protein HV012_RS04420 ENOG4105SYG Fimbrial protein HV012_RS04425 ENOG4108XEY fimbrial-like adhesin protein HV012_RS04430 ENOG4105CW0 outer membrane usher protein HV012_RS04435 ENOG4108VEV chaperone HV012_RS04445 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HV012_RS04450 ENOG4105DJ0 Poly(A) Polymerase HV012_RS04470 ENOG4107XID 2'-5' rna ligase HV012_RS04475 ENOG4105CQ7 ATP-dependent helicase HV012_RS04480 ENOG4105BZ4 penicillin-binding protein HV012_RS04485 ENOG4105E0K tonB-dependent siderophore receptor HV012_RS04490 ENOG4105E0A ABC, transporter HV012_RS04495 ENOG4105J76 Periplasmic binding protein HV012_RS04500 ENOG4105S6R Iron-hydroxamate transporter permease subunit HV012_RS04525 ENOG4105EN6 Membrane HV012_RS04530 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV012_RS04545 ENOG4105C0H protease HV012_RS04550 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HV012_RS04560 ENOG4105DIN metallophosphoesterase HV012_RS04575 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV012_RS04600 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HV012_RS04605 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HV012_RS04610 ENOG4105KNE Phosphatidate cytidylyltransferase HV012_RS04615 ENOG4105DZP Membrane-associated zinc metalloprotease HV012_RS04625 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HV012_RS04630 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV012_RS04650 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV012_RS04655 ENOG4105C0B DNA polymerase III (alpha subunit) HV012_RS04660 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HV012_RS04665 ENOG4105CXN decarboxylase HV012_RS04670 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HV012_RS04675 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HV012_RS04680 ENOG4105M1T rho-binding antiterminator HV012_RS04690 ENOG4108VWS Yaeq family HV012_RS04695 ENOG4108YZN class I peptide chain release factor HV012_RS04700 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HV012_RS04705 ENOG4108UY0 (LipO)protein HV012_RS04715 ENOG4108R96 Methyltransferase, YaeB family HV012_RS04720 ENOG4108R8X outer membrane lipoprotein HV012_RS04725 ENOG4105D01 (LipO)protein HV012_RS04730 ENOG4108UMI ABC transporter, permease HV012_RS04735 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV012_RS04740 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HV012_RS04790 ENOG4105CV8 reductase HV012_RS04795 ENOG4105HEI LysR family (Transcriptional regulator HV012_RS04805 ENOG4105F2W methyltransferase HV012_RS04810 ENOG4105E9H Lytic Murein transglycosylase HV012_RS04815 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HV012_RS04820 ENOG4105D1A Methyltransferase HV012_RS04830 ENOG4107RZZ dna polymerase iii epsilon subunit HV012_RS04840 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV012_RS04845 ENOG4108WN0 inhibitor of vertebrate lysozyme HV012_RS04850 ENOG4107QPN acyl-Coa dehydrogenase HV012_RS04860 ENOG4105E7A Glutamine amidotransferase HV012_RS04865 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HV012_RS04870 ENOG4108YS0 lipoprotein YafL HV012_RS04880 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV012_RS04900 ENOG4105CA3 membrane-bound lytic murein transglycosylase HV012_RS04905 ENOG4105CUZ uba thif-type nad fad binding protein HV012_RS04910 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV012_RS04915 ENOG4105C9B Cysteine desulfurase HV012_RS04920 ENOG4105M5B (LipO)protein HV012_RS04925 ENOG4105ETT transcriptional Regulator, LysR family HV012_RS04930 ENOG4105M08 Membrane HV012_RS04945 ENOG4105EJQ L-serine dehydratase HV012_RS04950 ENOG4105C44 Serine transporter HV012_RS04955 ENOG4105EWT decarboxylase family HV012_RS04975 ENOG4105WP7 tRNA pseudouridine synthase C HV012_RS04980 ENOG4105DR9 pseudouridine synthase HV012_RS04985 ENOG4105QDK Flavodoxin HV012_RS04990 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HV012_RS05005 ENOG4105EQX glucarate dehydratase HV012_RS05010 ENOG4105EQX glucarate dehydratase HV012_RS05015 ENOG4105BZW Glycerate kinase HV012_RS05020 ENOG4105BZU Histidine kinase HV012_RS05025 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HV012_RS05030 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV012_RS05035 ENOG4105DXN mazG family HV012_RS05050 ENOG4105HA9 of methanol dehydrogenase type HV012_RS05060 ENOG4105HA9 of methanol dehydrogenase type HV012_RS05070 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HV012_RS05080 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HV012_RS05095 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HV012_RS05105 ENOG4108MXK alkaline phosphatase isozyme conversion HV012_RS05125 ENOG4105N0Z inner membrane protein ygbE HV012_RS05160 ENOG4108K5P (LipO)protein HV012_RS05165 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV012_RS05175 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV012_RS05180 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV012_RS05185 ENOG4105KZM cytoplasmic protein HV012_RS05190 ENOG4105C6Z Gluconate HV012_RS05195 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HV012_RS05200 ENOG4105FB2 class II Aldolase HV012_RS05205 ENOG4105G63 Type III effector Hrp-dependent HV012_RS05210 ENOG4105ZXK Dehydrogenase HV012_RS05215 ENOG4105MVE transcriptional regulator HV012_RS05220 ENOG4105MEW serine threonine protein phosphatase HV012_RS05230 ENOG41067CV Integrase HV012_RS05285 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV012_RS05300 ENOG4105C2J ABC transporter HV012_RS05305 ENOG4105CNN ABC, transporter HV012_RS05310 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV012_RS05315 ENOG4107EDW L-fucose operon activator HV012_RS05320 ENOG4105VXR cytoplasmic protein HV012_RS05325 ENOG4105F4R Transcriptional regulator mode HV012_RS05330 ENOG4108JUA Transcriptional regulator HV012_RS05335 ENOG4105C45 hydrogenase expression formation protein (HypE) HV012_RS05340 ENOG4105CQS hydrogenase expression formation protein HypD HV012_RS05345 ENOG41083WG hydrogenase assembly chaperone HV012_RS05350 ENOG4107RSS Hydrogenase accessory protein HypB HV012_RS05355 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV012_RS05360 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HV012_RS05365 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV012_RS05370 ENOG4107R30 NADH dehydrogenase HV012_RS05375 ENOG4107TDF Formate hydrogenlyase subunit 4 HV012_RS05380 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV012_RS05385 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HV012_RS05390 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV012_RS05395 ENOG4105I6X formate hydrogenlyase maturation HV012_RS05400 ENOG4108MG9 hydrogenase 3 maturation protease HV012_RS05405 ENOG4105CS2 ec 3.2.1.21 HV012_RS05410 ENOG4105C5Y PTS System HV012_RS05415 ENOG4105DDV Transcriptional regulator (LacI family HV012_RS05420 ENOG4108RC0 Electron transport protein HV012_RS05425 ENOG4105C8H hydrogenase maturation protein Hypf HV012_RS05455 ENOG4105CVE Lytic murein transglycosylase HV012_RS05465 ENOG4107TH8 cina domain protein HV012_RS05485 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HV012_RS05515 ENOG4107VXZ Hydrolase HV012_RS05520 ENOG4105W39 Membrane HV012_RS05535 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV012_RS05540 ENOG4105CW7 secretion protein, HlyD family HV012_RS05545 ENOG4105NTK Transcriptional repressor Mpra HV012_RS05550 ENOG4105ZED uncharacterized protein ygaH HV012_RS05555 ENOG4108UMN azlc family HV012_RS05565 ENOG4105GIJ Glycine betaine HV012_RS05570 ENOG4108HQS Glycine betaine HV012_RS05575 ENOG4108IJ7 Glycine betaine HV012_RS05580 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV012_RS05585 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV012_RS05595 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HV012_RS05600 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV012_RS05610 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HV012_RS05615 ENOG4108WMJ Protein of unknown function (DUF2002) HV012_RS05630 ENOG4108X73 DNA- binding protein HV012_RS05635 ENOG4108V62 Rhodanese domain protein HV012_RS05640 ENOG41080HT Transcriptional regulator, arsr family HV012_RS05645 ENOG4105VPI YqaE family transport protein HV012_RS05650 ENOG4109066 lysm domain bon superfamily protein HV012_RS05655 ENOG4108PVQ transcriptional regulator HV012_RS05660 ENOG4105C85 amino acid HV012_RS05665 ENOG4108JPW Aminotransferase HV012_RS05670 ENOG4105C26 Dehydrogenase HV012_RS05675 ENOG4105D5U fad dependent oxidoreductase HV012_RS05685 ENOG4108NUU Transcriptional regulator HV012_RS05690 ENOG4105SZ2 membrAne HV012_RS05695 ENOG4107SNB ankyrin repeat protein YahD HV012_RS05700 ENOG4105N16 Protein of unknown function (DUF2877) HV012_RS05705 ENOG4107R1Q Membrane protein FdrA HV012_RS05710 ENOG4107REC cytoplasmic protein HV012_RS05720 ENOG4105C5B carbamate kinase HV012_RS05725 ENOG4105DZC cytosine deaminase HV012_RS05730 ENOG4105DTA methyltransferase HV012_RS05740 ENOG4105DQ4 alcohol dehydrogenase HV012_RS05745 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV012_RS05750 ENOG4108YZG isomerase HV012_RS05760 ENOG4105CMT Dihydroxyacetone kinase HV012_RS05765 ENOG4105CP7 Triose-phosphate isomerase HV012_RS05770 ENOG4108KFM Xylose Isomerase Domain-Containing protein HV012_RS05775 ENOG4106J7G oxidoreductase HV012_RS05780 ENOG4105DKT Transcriptional regulator HV012_RS05785 ENOG41083A2 UPF0145 protein HV012_RS05790 ENOG4105Y50 Virulence Protein HV012_RS05860 ENOG4105DFP Integrase HV012_RS05875 ENOG4108Z1B Cyclase dehydrase HV012_RS05885 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV012_RS05890 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HV012_RS05905 ENOG4108JU6 CBS domain protein HV012_RS05910 ENOG4106KVJ cytochrome C assembly protein HV012_RS05915 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HV012_RS05940 ENOG4105QP9 Protein of unknown function (DUF2799) HV012_RS05945 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV012_RS05950 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV012_RS05955 ENOG4105CQC Prephenate dehydratase HV012_RS05965 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HV012_RS05970 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV012_RS05975 ENOG4105C34 Pseudouridine synthase HV012_RS05980 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HV012_RS05985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV012_RS06010 ENOG4105CSH Transporter HV012_RS06015 ENOG4105T42 (LipO)protein HV012_RS06020 ENOG4105JIM Phosphatidylserine synthase HV012_RS06025 ENOG4105CD5 CoA-binding domain protein HV012_RS06030 ENOG4106IUH DTW domain containing protein HV012_RS06035 ENOG4105K63 Thioredoxin HV012_RS06040 ENOG4105EIB trna rrna methyltransferase HV012_RS06065 ENOG4105C1J atp-dependent rna helicase HV012_RS06075 ENOG4108IYU L-aspartate oxidase HV012_RS06085 ENOG4105EMN RNA polymerase sigma factor HV012_RS06090 ENOG41069PW sigma-e factor negative regulatory protein HV012_RS06095 ENOG4105VQK sigma E regulatory protein, MucB RseB HV012_RS06100 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HV012_RS06110 ENOG4105C3F Signal peptidase i HV012_RS06130 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HV012_RS06145 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HV012_RS06150 ENOG4106G6Q Transcriptional regulator HV012_RS06155 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HV012_RS06160 ENOG4108Z6B deaminase HV012_RS06170 ENOG4108ETH Formylglycinamide ribotide synthetase HV012_RS06175 ENOG4107WP9 Histidine kinase HV012_RS06180 ENOG4108SKK alpha helix protein HV012_RS06185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV012_RS06210 ENOG4107RE1 Inosine-guanosine kinase HV012_RS06215 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV012_RS06220 ENOG4105EU0 Major facilitator Superfamily HV012_RS06225 ENOG4105CGH 5'-nucleotidase HV012_RS06240 ENOG4108Z66 YbaK ebsC protein HV012_RS06245 ENOG4105MBR gumn family HV012_RS06250 ENOG41080ET plasmid maintenance system killer protein HV012_RS06255 ENOG41081XE plasmid maintenance system antidote protein, xre family HV012_RS06260 ENOG4105C59 p-type ATPase HV012_RS06265 ENOG4107RY6 amino acid HV012_RS06285 ENOG4107QZV Type I secretion membrane fusion protein HV012_RS06290 ENOG4108Z6Z Transcriptional regulator HV012_RS06295 ENOG4105G5H Membrane HV012_RS06300 ENOG4107QX8 SPFH domain, Band 7 family protein HV012_RS06305 ENOG41083J0 (ABC) transporter HV012_RS06310 ENOG4105C4B ABC transporter, permease HV012_RS06315 ENOG4107QR8 Thioredoxin HV012_RS06320 ENOG4105E1F short-chain dehydrogenase reductase HV012_RS06325 ENOG4108UJV acyl-CoA thioesterase i HV012_RS06330 ENOG4108I0Y (ABC) transporter HV012_RS06335 ENOG4105CV6 ABC transporter, permease HV012_RS06340 ENOG4105GMB type VI secretion system effector, hcp1 family HV012_RS06355 ENOG4105G5A Protein of unknown function (DUF2877) HV012_RS06360 ENOG4105C5B carbamate kinase HV012_RS06365 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HV012_RS06370 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HV012_RS06385 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV012_RS06395 ENOG4105S2T inner membrane protein YbcI HV012_RS06400 ENOG4105WQ3 Rna-binding protein HV012_RS06415 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV012_RS06425 ENOG4108SB3 DoxX Family HV012_RS06435 ENOG4105D8G Major Facilitator superfamily HV012_RS06440 ENOG4108MN2 Stationary phase inducible protein CsiE HV012_RS06445 ENOG4107XM9 (LipO)protein HV012_RS06450 ENOG4105ECY inositol monophosphatase HV012_RS06470 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HV012_RS06490 ENOG4108ZIT Ferredoxin, 2FE-2S HV012_RS06495 ENOG4105WVQ Fe-S assembly protein IscX HV012_RS06505 ENOG4105YYA enhanced serine sensitivity protein SseB HV012_RS06510 ENOG4105KHC sulfurtransferase HV012_RS06515 ENOG4105DN3 alpha-2-macroglobulin domain protein HV012_RS06520 ENOG4108JQB penicillin-binding protein 1C HV012_RS06550 ENOG4105N21 Membrane HV012_RS06565 ENOG4105VPD cellular component movement HV012_RS06600 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV012_RS06605 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HV012_RS06640 ENOG41076J9 exonuclease VIII HV012_RS06720 ENOG4108TFU terminase (Small subunit) HV012_RS06860 ENOG4105NVB glycoside hydrolase, family 19 HV012_RS06875 ENOG41066DY Membrane HV012_RS06880 ENOG4108ZMA Outer membrane lipoprotein HV012_RS06885 ENOG41062G3 Protein of unknown function (DUF2633) HV012_RS06890 ENOG4105BZU Histidine kinase HV012_RS06895 ENOG4105C9X ppx gppa phosphatase HV012_RS06900 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HV012_RS06905 ENOG4108V3E phosphoribosylglycinamide formyltransferase HV012_RS06920 ENOG4105C2W permease HV012_RS06925 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HV012_RS06930 ENOG4105K89 arsenate reductase HV012_RS06935 ENOG4105ERG peptidase m48, ste24p HV012_RS06940 ENOG4105C02 permease HV012_RS06945 ENOG4108JUA Transcriptional regulator HV012_RS06950 ENOG4105I6X formate hydrogenlyase maturation HV012_RS06955 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV012_RS06965 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV012_RS06970 ENOG4108JPZ Monovalent cation H antiporter subunit D HV012_RS06975 ENOG4107WQX hydrogenase 4 membrane subunit HV012_RS06980 ENOG4105D65 subunit l HV012_RS06985 ENOG4107TDF Formate hydrogenlyase subunit 4 HV012_RS06990 ENOG4108JPZ Monovalent cation H antiporter subunit D HV012_RS06995 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV012_RS07000 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV012_RS07005 ENOG4105RH4 Glycine cleavage system transcriptional repressor HV012_RS07015 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV012_RS07025 ENOG4105CGZ zinc metallopeptidase HV012_RS07035 ENOG4106KED esterase YpfH HV012_RS07050 ENOG4105KUZ arsenate reductase HV012_RS07060 ENOG4105BZS acriflavin resistance protein HV012_RS07065 ENOG4105BZU Histidine kinase HV012_RS07070 ENOG4105BZ8 glutamate synthase HV012_RS07080 ENOG4108PVD exported protein HV012_RS07085 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV012_RS07090 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV012_RS07095 ENOG4105C6K Malic enzyme HV012_RS07115 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HV012_RS07125 ENOG4105QZU Inner membrane protein YfeZ HV012_RS07130 ENOG4105E7K (LipO)protein HV012_RS07135 ENOG4105EZR dyp-type peroxidase family protein HV012_RS07140 ENOG4107S1E Beta-lactamase HV012_RS07145 ENOG4105C5Y PTS System HV012_RS07160 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HV012_RS07165 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HV012_RS07170 ENOG4108I5D sulfate abc transporter HV012_RS07175 ENOG4105ECW sulfate abc transporter HV012_RS07180 ENOG4108IJ6 ABC transporter HV012_RS07185 ENOG4105C6T cysteine synthase HV012_RS07190 ENOG4105M0Y HV012_RS07200 ENOG4105C5Y PTS System HV012_RS07205 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV012_RS07215 ENOG4105C6T cysteine synthase HV012_RS07225 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HV012_RS07235 ENOG4105VRT cytoplasmic protein HV012_RS07240 ENOG4105DHU Bile acid HV012_RS07245 ENOG4108NFH Sugar hydrolase HV012_RS07250 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HV012_RS07255 ENOG4105EAA nucleoside HV012_RS07265 ENOG4105CN8 Transcriptional regulator HV012_RS07290 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HV012_RS07295 ENOG4105GXM Putative transcription regulator (DUF1323) HV012_RS07300 ENOG4105HZG regulatoR HV012_RS07315 ENOG4108KMM Diguanylate cyclase HV012_RS07320 ENOG4105D9N nucleoside HV012_RS07330 ENOG4109076 Conserved Protein HV012_RS07345 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HV012_RS07350 ENOG410863U PTS System HV012_RS07355 ENOG4105DC7 peptidase M24 HV012_RS07360 ENOG4105CN9 Peptidase m42 family protein HV012_RS07365 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV012_RS07370 ENOG4108CIP transcriptional regulator HV012_RS07375 ENOG4105DY9 regulatoR HV012_RS07380 ENOG4108HRK Histidine kinase HV012_RS07385 ENOG4105CHM Aminotransferase HV012_RS07395 ENOG4105D1S lipid A biosynthesis HV012_RS07400 ENOG4105W9M Membrane HV012_RS07415 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HV012_RS07435 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HV012_RS07445 ENOG4105CHR reductase HV012_RS07455 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HV012_RS07485 ENOG4108V1U phospholipid-binding protein HV012_RS07490 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV012_RS07505 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV012_RS07510 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV012_RS07520 ENOG4105CHW UPF0052 protein HV012_RS07530 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV012_RS07540 ENOG4105M00 molybdopterin converting factor, subunit 1 HV012_RS07545 ENOG4108ZAF Molybdopterin HV012_RS07550 ENOG4105HFZ Membrane HV012_RS07555 ENOG4105DIJ Phosphoethanolamine transferase HV012_RS07560 ENOG410733J conserved inner membrane protein HV012_RS07575 ENOG4107UXM Membrane HV012_RS07580 ENOG4105DZQ phospholipase D Transphosphatidylase HV012_RS07585 ENOG4105X23 Endonuclease Exonuclease phosphatase HV012_RS07590 ENOG4105I9U inner membrane protein ybhQ HV012_RS07595 ENOG4107QWP ABC-2 type transporter HV012_RS07600 ENOG4107QWP ABC-2 type transporter HV012_RS07605 ENOG4105CJ1 ABC, transporter HV012_RS07615 ENOG4107MVR Transcriptional regulator HV012_RS07620 ENOG4105C1J atp-dependent rna helicase HV012_RS07625 ENOG4105DVT helicase HV012_RS07630 ENOG4108MTB glycosyl transferase family HV012_RS07635 ENOG4105DG4 malate L-lactate dehydrogenase HV012_RS07640 ENOG4105VR4 UPF0379 protein ybiJ HV012_RS07645 ENOG4105KSC Transcriptional regulator, TraR DksA family HV012_RS07655 ENOG4108IU3 tonb-dependent siderophore receptor HV012_RS07660 ENOG4105ZY9 UPF0379 protein ybiM HV012_RS07670 ENOG4105D8X mechanosensitive ion channel HV012_RS07680 ENOG4108ZNS ferredoxin-type protein NapF HV012_RS07685 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HV012_RS07695 ENOG4108BGM Quinol dehydrogenase periplasmic component HV012_RS07700 ENOG4105GXZ Ferredoxin-type protein NapH HV012_RS07705 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HV012_RS07710 ENOG4105CUW cytochrome C-TYPE protein HV012_RS07715 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HV012_RS07720 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HV012_RS07725 ENOG41060IM Heme exporter protein HV012_RS07730 ENOG4105X3C heme exporter protein HV012_RS07740 ENOG4105DA4 cytochrome c-type biogenesis protein HV012_RS07745 ENOG4107QX9 Thiol disulfide interChange protein HV012_RS07750 ENOG4105KWW Biogenesis protein HV012_RS07755 ENOG4105WH1 Two component transcriptional regulator luxr family HV012_RS07760 ENOG410658X HV012_RS07775 ENOG4105E68 Sulfatase HV012_RS07800 ENOG4105CFI type iii restriction protein res subunit HV012_RS07805 ENOG4105I08 Pseudouridine synthase HV012_RS07810 ENOG4105C2C drug resistance transporter, Bcr CflA HV012_RS07815 ENOG4105HG6 HV012_RS07820 ENOG4108JQ5 ABC transporter HV012_RS07825 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HV012_RS07830 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HV012_RS07835 ENOG4105E43 Extracellular solute-binding protein, family 5 HV012_RS07840 ENOG4105CXC rtn protein HV012_RS07845 ENOG4107TT5 NLP P60 protein HV012_RS07850 ENOG41076MN Phosphoesterase, PA-phosphatase related HV012_RS07855 ENOG4105CKI cobalamin synthesis protein HV012_RS07860 ENOG4105DEI Mannitol dehydrogenase HV012_RS07870 ENOG4105KRS Proteinase inhibitor HV012_RS07875 ENOG4105S8Q sugar efflux transporter HV012_RS07880 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV012_RS07885 ENOG4105DE4 1-phosphofructokinase HV012_RS07890 ENOG4105DM4 PTS System HV012_RS07895 ENOG4105DD7 kinase (PfkB family HV012_RS07900 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HV012_RS07905 ENOG4105D9N nucleoside HV012_RS07910 ENOG4108Y4K DNA-binding transcriptional activator HV012_RS07920 ENOG4105D9N nucleoside HV012_RS07925 ENOG4105DD7 kinase (PfkB family HV012_RS07935 ENOG4105HMI Membrane HV012_RS07940 ENOG4105DUM transcriptional regulator, lysR family HV012_RS07945 ENOG4108IQI permease HV012_RS07950 ENOG4105D05 Receptor HV012_RS07965 ENOG4105DHF Membrane HV012_RS07970 ENOG41060NJ transcriptional regulator HV012_RS07975 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HV012_RS07980 ENOG4105C2J ABC transporter HV012_RS07985 ENOG4108HWV )-transporter HV012_RS07990 ENOG4107SJI Dehydrogenase HV012_RS07995 ENOG4105BZ8 glutamate synthase HV012_RS08000 ENOG4105Y9N Membrane HV012_RS08005 ENOG4107GZ4 SanA protein HV012_RS08015 ENOG41067MG lrgb family HV012_RS08025 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HV012_RS08050 ENOG4105KHU inner membrane protein YohD HV012_RS08055 ENOG41069YE inner membrane protein yohC HV012_RS08060 ENOG41061WM D-Alanyl-D-Alanine HV012_RS08065 ENOG4105CXG d-lactate dehydrogenase HV012_RS08070 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV012_RS08075 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV012_RS08080 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HV012_RS08085 ENOG4108IJ8 ABC transporter HV012_RS08090 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HV012_RS08100 ENOG4108XDN Transcriptional regulator HV012_RS08105 ENOG4108HRK Histidine kinase HV012_RS08110 ENOG4108NEV two component transcriptional regulator, LytTR family HV012_RS08115 ENOG4108W15 Protein of unknown function (DUF1456) HV012_RS08120 ENOG4108YCW (LipO)protein HV012_RS08125 ENOG410903U zinc ion binding HV012_RS08130 ENOG4105DEG Vwa containing coxe family protein HV012_RS08135 ENOG4105RD5 HV012_RS08140 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HV012_RS08150 ENOG4108KDT Molybdate metabolism regulator HV012_RS08155 ENOG4108KDT Molybdate metabolism regulator HV012_RS08160 ENOG4108KDT Molybdate metabolism regulator HV012_RS08170 ENOG4105D1F ATP-binding protein HV012_RS08175 ENOG41067AK Protein of unknown function (DUF2574) HV012_RS08185 ENOG4108MQF Chaperone HV012_RS08190 ENOG4105CW0 outer membrane usher protein HV012_RS08195 ENOG410662B Type-1 fimbrial protein HV012_RS08200 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HV012_RS08255 ENOG4105DWF phosphomethylpyrimidine kinase HV012_RS08260 ENOG4108UQ1 hydrolase, family 25 HV012_RS08265 ENOG4105FDP GntR family transcriptional regulator HV012_RS08270 ENOG4108TFM Kinase, PfkB family HV012_RS08275 ENOG4108KD5 ADP-ribosylation crystallin J1 HV012_RS08280 ENOG4105EAA nucleoside HV012_RS08285 ENOG4105EIE fructose-bisphosphate aldolase HV012_RS08290 ENOG4105IE8 Alpha-ketoglutarate permease HV012_RS08295 ENOG4105EF1 ribulokinase HV012_RS08315 ENOG4105DEI Mannitol dehydrogenase HV012_RS08320 ENOG4105CMG Carbohydrate kinase HV012_RS08325 ENOG4105IE8 Alpha-ketoglutarate permease HV012_RS08330 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV012_RS08340 ENOG4105CFP Peptidase U32 HV012_RS08350 ENOG4105X54 addiction module antidote protein HV012_RS08355 ENOG4105KWI UPF0339 protein HV012_RS08360 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV012_RS08365 ENOG4105EB3 Histidine kinase HV012_RS08395 ENOG4108M24 von Willebrand factor, type A HV012_RS08400 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HV012_RS08405 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HV012_RS08410 ENOG4105R8A Heat shock protein HV012_RS08415 ENOG4105D03 DNA-3-methyladenine glycosylase II HV012_RS08420 ENOG4105BZU Histidine kinase HV012_RS08435 ENOG4108GAE asmA family HV012_RS08440 ENOG4105EE5 Membrane protein terC HV012_RS08445 ENOG4105DAY polysaccharide export protein HV012_RS08450 ENOG4105KJF protein tyrosine phosphatase HV012_RS08455 ENOG4105D75 Capsular exopolysaccharide family HV012_RS08460 ENOG41090RK glycosyl transferase HV012_RS08465 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HV012_RS08470 ENOG4107RXY Glycosyl transferase HV012_RS08475 ENOG4108NYJ Colanic acid HV012_RS08480 ENOG4105ECJ Glycosyl Transferase HV012_RS08485 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HV012_RS08490 ENOG4105C0K Gdp-mannose 4,6-dehydratase HV012_RS08495 ENOG4105C30 Nad-dependent epimerase dehydratase HV012_RS08500 ENOG4105FGF GDP-mannose mannosyl hydrolase HV012_RS08505 ENOG4106CD9 glycosyl transferase group 1 HV012_RS08510 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV012_RS08515 ENOG4107QKV phosphomannomutase HV012_RS08520 ENOG4105D3Q Sugar transferase HV012_RS08525 ENOG4105PSV Polysaccharide Biosynthesis Protein HV012_RS08530 ENOG4105C74 pyruvyl transferase HV012_RS08535 ENOG4107T8Q Glycosyl transferase (Group 1 HV012_RS08540 ENOG4105G1A colanic acid biosynthesis protein HV012_RS08545 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV012_RS08600 ENOG4105C30 Nad-dependent epimerase dehydratase HV012_RS08605 ENOG4105FGF GDP-mannose mannosyl hydrolase HV012_RS08610 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV012_RS08625 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HV012_RS08655 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV012_RS08660 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HV012_RS08665 ENOG4105CIH Imidazole acetol-phosphate transaminase HV012_RS08670 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HV012_RS08685 ENOG4105VTW prevent-host-death family HV012_RS08690 ENOG4105KRQ Addiction module toxin, Txe YoeB family HV012_RS08695 ENOG4107SRH Nad-dependent epimerase dehydratase HV012_RS08700 ENOG4105EQ1 Transcriptional regulator HV012_RS08710 ENOG4105CUB amino acid HV012_RS08715 ENOG4105CUC YeeE YedE family protein HV012_RS08725 ENOG4105CJB Exodeoxyribonuclease I HV012_RS08730 ENOG4105DFP Integrase HV012_RS08765 ENOG41077V0 CPS-53 (KpLE1) prophage HV012_RS08850 ENOG4105CDU Replicative dna helicase HV012_RS08880 ENOG4105RWQ Protein of unknown function (DUF1364) HV012_RS08905 ENOG4105KUS lysozyme HV012_RS08910 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV012_RS09040 ENOG4105DR8 Membrane HV012_RS09055 ENOG4105KTW ethanolamine utilization protein HV012_RS09060 ENOG4105M3W utilization protein HV012_RS09070 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HV012_RS09080 ENOG4108EKI Dehydrogenase HV012_RS09090 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV012_RS09110 ENOG4105KNY Microcompartments protein HV012_RS09120 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HV012_RS09125 ENOG4108ZFT Dehydratase small subunit HV012_RS09130 ENOG4105YCI dehydratase medium subunit HV012_RS09140 ENOG4105EHR propanediol utilization protein pduB HV012_RS09145 ENOG4105KNY Microcompartments protein HV012_RS09150 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV012_RS09155 ENOG4107XVH Transcriptional regulator HV012_RS09165 ENOG4108P62 biosynthesis protein (CbiG) HV012_RS09170 ENOG4108PXI ErfK YbiS YcfS YnhG HV012_RS09190 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HV012_RS09195 ENOG4105KNY Microcompartments protein HV012_RS09200 ENOG4105F1A Pyruvate formate-lyase HV012_RS09205 ENOG4105C6N Formate acetyltransferase HV012_RS09210 ENOG4105C0A alcohol dehydrogenase HV012_RS09220 ENOG4105C0A alcohol dehydrogenase HV012_RS09225 ENOG4105KNY Microcompartments protein HV012_RS09230 ENOG4105KNY Microcompartments protein HV012_RS09235 ENOG4105KNY Microcompartments protein HV012_RS09270 ENOG4105CSH Transporter HV012_RS09275 ENOG4105FYV Amp nucleosidase HV012_RS09305 ENOG4107R11 Transcriptional regulator HV012_RS09380 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HV012_RS09390 ENOG4105WPN DNA integration recombination invertion protein HV012_RS09405 ENOG4108MXB Protein of unknown function (DUF968) HV012_RS09410 ENOG4105KSK (crossover) junction endodeoxyribonuclease HV012_RS09440 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HV012_RS09490 ENOG4105EFC phage portal protein HK97 family HV012_RS09580 ENOG4108X9F tail fiber protein HV012_RS09615 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV012_RS09625 ENOG4105ZIT Porin Gram-negative type HV012_RS09630 ENOG4105Y0K Inner membrane protein YedR HV012_RS09635 ENOG4105EST Metal Dependent Phosphohydrolase HV012_RS09640 ENOG41090BB DNA mismatch endonuclease (vsr) HV012_RS09645 ENOG4105FDR Membrane HV012_RS09650 ENOG4105CKW Inner membrane protein yedI HV012_RS09655 ENOG4105VNZ cytoplasmic protein HV012_RS09670 ENOG4105YX3 cellular response to acidity HV012_RS09680 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HV012_RS09685 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV012_RS09690 ENOG4105VS8 Flagellar biosynthetic protein fliq HV012_RS09695 ENOG4105CN7 Flagellar biosynthetic protein FliP HV012_RS09700 ENOG4105K0P flagellar biosynthesis protein HV012_RS09705 ENOG4105DD5 Flagellar motor switch protein HV012_RS09710 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV012_RS09715 ENOG4107ZI8 flagellar basal body-associated protein flil HV012_RS09720 ENOG4105WF4 Flagellar hook-length control protein HV012_RS09725 ENOG4105GSA Flagellar export protein flij HV012_RS09730 ENOG4108JIR Flagellum-specific ATP synthase HV012_RS09735 ENOG41090PJ Flagellar assembly protein HV012_RS09740 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV012_RS09745 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HV012_RS09755 ENOG4105KT5 UmuD protein HV012_RS09760 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV012_RS09765 ENOG4107BJW polysaccharide deacetylase HV012_RS09770 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HV012_RS09775 ENOG4108MJ5 VirK protein HV012_RS09780 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV012_RS09785 ENOG4105C26 Dehydrogenase HV012_RS09795 ENOG4105CK7 Sodium proline symporter HV012_RS09805 ENOG410650H (LipO)protein HV012_RS09810 ENOG4105DBE peroxidase HV012_RS09820 ENOG4105D5M phosphate starvation-inducible protein HV012_RS09830 ENOG4105CND Glycosyl transferase, family 2 HV012_RS09835 ENOG4107BJW polysaccharide deacetylase HV012_RS09840 ENOG4108TUY outer membrane protein PgaA HV012_RS09845 ENOG4105BZU Histidine kinase HV012_RS09850 ENOG4108M3R transcriptional activator CadC HV012_RS09855 ENOG4105D5Q Arginine ornithine antiporter HV012_RS09860 ENOG4105CXN decarboxylase HV012_RS09865 ENOG4105DUX Transporter HV012_RS09870 ENOG4105CRK lysyL-tRNA synthetase HV012_RS09890 ENOG4107XHZ cytoplasmic chaperone TorD family protein HV012_RS09895 ENOG4108UQ5 membrane protein YcdZ HV012_RS09900 ENOG4105P8Q Curli production assembly transport component CsgG HV012_RS09905 ENOG4108WYR Curli production assembly transport component, CsgF HV012_RS09910 ENOG4108XDW curli assembly protein CsgE HV012_RS09915 ENOG41086KC Transcriptional regulator HV012_RS09920 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HV012_RS09925 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HV012_RS09930 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HV012_RS09945 ENOG4107RZC phospholipase d HV012_RS09950 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HV012_RS09960 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HV012_RS09965 ENOG4105NAC (LipO)protein HV012_RS09970 ENOG4108W47 Acidic protein msyB HV012_RS09980 ENOG4105D1S lipid A biosynthesis HV012_RS09990 ENOG4108YYC ycei family HV012_RS09995 ENOG4105DS1 cytochrome b561 HV012_RS10005 ENOG4105PVA Biofilm formation regulatory protein BssS HV012_RS10010 ENOG4105MEA DNA damage-inducible protein i HV012_RS10020 ENOG4105F3T (LipO)protein HV012_RS10040 ENOG4105D9U N-acetyltransferase HV012_RS10050 ENOG4105EP9 oxidoreductase HV012_RS10055 ENOG4105CJR Integral membrane protein (MviN HV012_RS10060 ENOG4105QVD Flagella synthesis protein FlgN HV012_RS10065 ENOG4105M9M anti-sigma28 factor FlgM HV012_RS10070 ENOG4105CKS Flagella basal body P-ring formation protein flgA HV012_RS10075 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HV012_RS10080 ENOG4108ZC9 flagellar basal-body rod protein flgc HV012_RS10085 ENOG4105W00 Flagellar hook capping protein HV012_RS10090 ENOG4105BZE flagellar hook protein, FlgE HV012_RS10095 ENOG4108KPB Flagellar basal-body rod protein FlgF HV012_RS10100 ENOG4105CGA flagellar basal-body rod protein FlgG HV012_RS10115 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV012_RS10120 ENOG4105E1Q flagellar hook-associated protein HV012_RS10125 ENOG4105DTJ flagellar hook-associated protein HV012_RS10130 ENOG4107QQB Ribonuclease E HV012_RS10135 ENOG4105EI2 Pseudouridine synthase HV012_RS10140 ENOG4108UHJ MAF-like protein HV012_RS10145 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HV012_RS10150 ENOG4105VGS 50s ribosomal protein l32 HV012_RS10160 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HV012_RS10165 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV012_RS10170 ENOG4105CHR reductase HV012_RS10175 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV012_RS10180 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV012_RS10185 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HV012_RS10190 ENOG4105HHA aminodeoxychorismate lyase HV012_RS10200 ENOG4107QRG dna polymerase iii HV012_RS10205 ENOG4105F8V Hydrolase, tatD family HV012_RS10210 ENOG4105CI1 PTS System HV012_RS10215 ENOG4105K59 histidine triad (HIT) protein HV012_RS10220 ENOG41090DQ Lipoprotein HV012_RS10225 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HV012_RS10230 ENOG4108RUM thiamine kinase HV012_RS10245 ENOG4105CEP NADH dehydrogenase HV012_RS10250 ENOG4107MBR 17 kDa surface antigen HV012_RS10260 ENOG4105Y3U Transglycosylase-associated protein HV012_RS10270 ENOG4106G4W HV012_RS10275 ENOG410620I Diguanylate cyclase HV012_RS10280 ENOG4105UCG Domain of unknown function (DUF333) HV012_RS10285 ENOG4105K78 MarR family Transcriptional regulator HV012_RS10290 ENOG4105DJ2 Major Facilitator Superfamily HV012_RS10305 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HV012_RS10310 ENOG4108KHP Diguanylate cyclase HV012_RS10315 ENOG4106KTS Inner membrane protein yeaI HV012_RS10325 ENOG4105CYN Serine protein kinase HV012_RS10330 ENOG4105GNX MltA-interacting MipA family protein HV012_RS10335 ENOG4105CV8 reductase HV012_RS10340 ENOG4105EZE Cupin 4 family protein HV012_RS10345 ENOG4105IFJ Histidine kinase HV012_RS10350 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV012_RS10355 ENOG4107QTF adenylosuccinate lyase HV012_RS10380 ENOG4108HMX isocitrate dehydrogenase (NADP) HV012_RS10395 ENOG4105CDY transcriptional regulatory protein HV012_RS10400 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HV012_RS10415 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HV012_RS10425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV012_RS10430 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HV012_RS10435 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HV012_RS10445 ENOG4107QMS site-determining protein HV012_RS10460 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HV012_RS10470 ENOG4105TNG K13735 adhesin invasin HV012_RS10475 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HV012_RS10490 ENOG4105ED1 spovr family HV012_RS10500 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV012_RS10510 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HV012_RS10520 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HV012_RS10530 ENOG4105E53 ec 3.2.1.28 HV012_RS10535 ENOG4105C3G gtp-binding protein HV012_RS10545 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HV012_RS10550 ENOG4105CHH sulfate transporter HV012_RS10555 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV012_RS10580 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HV012_RS10590 ENOG41063JG Transcriptional regulator HV012_RS10605 ENOG4105EWV Sodium calcium exchanger membrane region HV012_RS10610 ENOG4105WS7 Cation transport regulator HV012_RS10615 ENOG4108NH8 Cation transport protein HV012_RS10620 ENOG41090EX DsrE family HV012_RS10625 ENOG4105ID0 Putative invasin HV012_RS10630 ENOG4105WH1 Two component transcriptional regulator luxr family HV012_RS10635 ENOG4105BZU Histidine kinase HV012_RS10640 ENOG4105DQQ Major facilitator superfamily MFS_1 HV012_RS10645 ENOG4105CRU nitrate reductase, alpha subunit HV012_RS10650 ENOG4108IUE nitrate reductase beta subunit HV012_RS10655 ENOG4105R3A Nitrate reductase HV012_RS10660 ENOG41076YT nitrate reductase, gamma subunit HV012_RS10665 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HV012_RS10670 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV012_RS10715 ENOG4105CIY formyltetrahydrofolate deformylase HV012_RS10725 ENOG4105D78 K07001 NTE family protein HV012_RS10730 ENOG4105I93 response regulator HV012_RS10735 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV012_RS10745 ENOG4107104 thymidine kinase HV012_RS10755 ENOG4105C0A alcohol dehydrogenase HV012_RS10760 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HV012_RS10765 ENOG4107QSI ABC, transporter HV012_RS10770 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV012_RS10775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV012_RS10780 ENOG4105C3U ABC transporter HV012_RS10785 ENOG4108JQ7 (ABC) transporter HV012_RS10790 ENOG4105EYW Ion transport protein HV012_RS10805 ENOG4105D7V transposase HV012_RS10815 ENOG4105K9H YciI-like protein HV012_RS10820 ENOG410822N TonB family HV012_RS10825 ENOG4105NAU thioesterase Superfamily protein HV012_RS10840 ENOG4105PI0 Ferredoxin HV012_RS10845 ENOG4105EIF outer membrane protein W HV012_RS10850 ENOG4108I1J Integrase HV012_RS10900 ENOG4105EIF outer membrane protein W HV012_RS10905 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HV012_RS10915 ENOG4105DK0 Indole-3-glycerol phosphate synthase HV012_RS10920 ENOG4108EFP Anthranilate synthase component II HV012_RS10925 ENOG4105CRQ synthase (Component I) HV012_RS10935 ENOG4105DB7 PHP domain protein HV012_RS10940 ENOG4107RTD sua5 ycio yrdc ywlc family protein HV012_RS10945 ENOG4105EG3 transmembrane signal peptide protein HV012_RS10950 ENOG4105FE9 pseudouridine synthase HV012_RS10955 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV012_RS10960 ENOG4105UBK short-chain dehydrogenase reductase HV012_RS10965 ENOG4105ERU peptidase HV012_RS10970 ENOG4105RKX Protein of unknown function (DUF2498) HV012_RS10975 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV012_RS10980 ENOG4107R11 Transcriptional regulator HV012_RS10995 ENOG4107QM5 aconitate hydratase HV012_RS11005 ENOG4105EYK Phosphatidylglycerophosphatase B HV012_RS11010 ENOG4105Q4A inner membrane protein yciS HV012_RS11015 ENOG4105CFV Tetratricopeptide repeat protein HV012_RS11025 ENOG4108ZJT translation initiation factor, Sui1 HV012_RS11035 ENOG4105N2W Transcriptional regulator HV012_RS11045 ENOG4105BZU Histidine kinase HV012_RS11055 ENOG4105Q4T oxidoreductase HV012_RS11060 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HV012_RS11065 ENOG4108JQ2 peptide transport system atp-binding protein HV012_RS11070 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HV012_RS11075 ENOG4108EU3 peptide transport system, permease HV012_RS11080 ENOG4108I5W peptide transport system, permease protein HV012_RS11085 ENOG4108HIY periplasmic HV012_RS11090 ENOG4105E51 psp operon transcriptional activator HV012_RS11095 ENOG41087YS Phage shock protein A HV012_RS11100 ENOG4105YYT phage shock protein B HV012_RS11105 ENOG4105FM1 phage shock protein C HV012_RS11110 ENOG4105NNG Peripheral inner membrane phage-shock protein HV012_RS11115 ENOG4105K8Z Phage shock protein HV012_RS11120 ENOG4105CM6 amino acid regulated cytosolic protein HV012_RS11130 ENOG4108JU8 Transcriptional regulator HV012_RS11135 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HV012_RS11140 ENOG4107S8C mandelate racemase muconate lactonizing HV012_RS11145 ENOG4105KXI murein peptide amidase A HV012_RS11150 ENOG4107QSI ABC, transporter HV012_RS11155 ENOG4105D64 Mechanosensitive ion channel HV012_RS11160 ENOG4105S5I Membrane HV012_RS11165 ENOG4105Q9Y Universal stress protein HV012_RS11170 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV012_RS11175 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV012_RS11180 ENOG4108DG9 Smr protein MutS2 HV012_RS11185 ENOG4107HP6 Transcriptional regulator HV012_RS11195 ENOG4107QNJ CoA-transferase subunit B HV012_RS11200 ENOG4105CHU acetyl-coa acetyltransferase HV012_RS11220 ENOG4105F2Z 3-oxoadipate enol-lactonase HV012_RS11225 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HV012_RS11230 ENOG4105BZU Histidine kinase HV012_RS11245 ENOG4105C1J atp-dependent rna helicase HV012_RS11255 ENOG4108RW8 Universal stress protein F HV012_RS11260 ENOG4105FCK Membrane HV012_RS11265 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HV012_RS11275 ENOG4105IKK cytoplasmic protein HV012_RS11280 ENOG41090X5 Heat shock protein hslJ HV012_RS11285 ENOG4105C5I Dehydrogenase HV012_RS11290 ENOG4107H52 Dicarboxylate transport HV012_RS11295 ENOG410689M (LipO)protein HV012_RS11300 ENOG4105WXT Conserved Protein HV012_RS11305 ENOG4108WFR AraC Family Transcriptional Regulator HV012_RS11310 ENOG4105C26 Dehydrogenase HV012_RS11315 ENOG4105F11 amine oxidase HV012_RS11320 ENOG4105DXM phenylacetic acid degradation protein HV012_RS11325 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HV012_RS11330 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HV012_RS11335 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HV012_RS11340 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HV012_RS11345 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV012_RS11350 ENOG4105E39 Enoyl-CoA hydratase HV012_RS11355 ENOG4108UKI Enoyl-CoA hydratase HV012_RS11360 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV012_RS11365 ENOG4108ZJI phenylacetic acid degradation protein HV012_RS11370 ENOG4105CHU acetyl-coa acetyltransferase HV012_RS11375 ENOG4105DZS Phenylacetate-CoA ligase HV012_RS11380 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HV012_RS11385 ENOG4108Z0R Transferase HV012_RS11390 ENOG4107S5I aldo keto reductase HV012_RS11400 ENOG4105CQ7 ATP-dependent helicase HV012_RS11410 ENOG4107DB1 DUF218 domain HV012_RS11415 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV012_RS11420 ENOG4105CPW cytochrome b561 HV012_RS11435 ENOG4105BZU Histidine kinase HV012_RS11440 ENOG4105BZU Histidine kinase HV012_RS11445 ENOG4105F32 YngK protein HV012_RS11450 ENOG4105E5D amino acid HV012_RS11455 ENOG4105CVK Glutamate decarboxylase HV012_RS11460 ENOG4107RAN Peptidase, M16 HV012_RS11465 ENOG4105PE1 Receptor HV012_RS11470 ENOG4105CQ0 ABC transporter HV012_RS11485 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HV012_RS11495 ENOG4105C2J ABC transporter HV012_RS11520 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HV012_RS11540 ENOG4105FFC UPF0187 protein HV012_RS11550 ENOG4105BZU Histidine kinase HV012_RS11560 ENOG4105M0C cytoplasmic protein HV012_RS11565 ENOG4105CSV Glutaminase HV012_RS11570 ENOG4105C26 Dehydrogenase HV012_RS11575 ENOG4105EGI Transcriptional regulator HV012_RS11590 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HV012_RS11595 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV012_RS11600 ENOG4106DNR multiple antibiotic resistance protein HV012_RS11605 ENOG4108594 Permease of the drug metabolite transporter HV012_RS11610 ENOG4105E5W Transporter HV012_RS11615 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HV012_RS11620 ENOG4108YDI single-species biofilm formation on inanimate substrate HV012_RS11625 ENOG4108WTK competence damage-inducible protein HV012_RS11635 ENOG4105EMU Dehydrogenase HV012_RS11640 ENOG4107XBN GntR Family Transcriptional Regulator HV012_RS11645 ENOG41061EV selenium-binding protein YdfZ HV012_RS11650 ENOG4105DEI Mannitol dehydrogenase HV012_RS11660 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV012_RS11665 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV012_RS11670 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV012_RS11680 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HV012_RS11685 ENOG4105CPQ Dehydrogenase HV012_RS11690 ENOG4105CXK mandelate racemase muconate lactonizing HV012_RS11705 ENOG4108MK9 spermidine N(1)-acetyltransferase HV012_RS11715 ENOG4105KBG Protein of unknown function (DUF1161) HV012_RS11720 ENOG410654E Membrane HV012_RS11735 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HV012_RS11740 ENOG4105D81 ABC transporter, permease HV012_RS11745 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV012_RS11750 ENOG4107TYH extracellular solute-binding protein family 1 HV012_RS11755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV012_RS11760 ENOG4105RR0 Protein of unknown function (DUF2554) HV012_RS11785 ENOG4108KKZ (LipO)protein HV012_RS11790 ENOG41088CC tellurite resistance protein tehB HV012_RS11795 ENOG4107WE3 acetyltransferase YdcK HV012_RS11800 ENOG4108Z9I -acetyltransferase HV012_RS11805 ENOG4105Z2P Protein of unknown function (DUF465) HV012_RS11815 ENOG4105E32 cytoplasmic protein HV012_RS11820 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HV012_RS11825 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HV012_RS11830 ENOG4105DDW LysR family Transcriptional regulator HV012_RS11840 ENOG4108Z9K Osmotically inducible protein HV012_RS11845 ENOG4105TPS biofilm-dependent modulation protein HV012_RS11850 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HV012_RS11860 ENOG4105DQ4 alcohol dehydrogenase HV012_RS11865 ENOG41084S7 Plasmid maintenance system antidote protein HV012_RS11870 ENOG4108MG3 formate dehydrogenase HV012_RS11875 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV012_RS11885 ENOG4105RPH Inner membrane protein YddG HV012_RS11890 ENOG4105FCK Membrane HV012_RS11920 ENOG410626B catechol 1,2-dioxygenase HV012_RS11925 ENOG4105NN7 muconolactone delta-isomerase HV012_RS11930 ENOG4105DTQ mandelate racemase muconate lactonizing HV012_RS11935 ENOG4107HP6 Transcriptional regulator HV012_RS11940 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV012_RS11945 ENOG4108MEJ flavin reductase domain protein HV012_RS11960 ENOG4105DIA mandelate racemase muconate lactonizing HV012_RS11965 ENOG4105JAB phenazine biosynthesis protein, phzf family HV012_RS11975 ENOG4108MEJ flavin reductase domain protein HV012_RS11985 ENOG410600T transposase HV012_RS12015 ENOG4108N27 Glutathione S-transferase HV012_RS12020 ENOG4105C85 amino acid HV012_RS12025 ENOG4108NS2 receptor HV012_RS12030 ENOG4105CHB tonB-dependent Receptor HV012_RS12035 ENOG4108WYP Transcriptional regulator HV012_RS12040 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HV012_RS12045 ENOG4108Z7F N-acetyltransferase HV012_RS12050 ENOG4108T9Y Inner membrane protein ydcZ HV012_RS12055 ENOG4105R71 cytoplasmic protein HV012_RS12060 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HV012_RS12065 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV012_RS12070 ENOG4105E90 ABC transporter HV012_RS12075 ENOG4108IJ8 ABC transporter HV012_RS12080 ENOG4105CMQ Chloride channel HV012_RS12085 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV012_RS12090 ENOG4105DAG ROK family HV012_RS12095 ENOG4106NZI LysR family Transcriptional regulator HV012_RS12100 ENOG4105D94 Major Facilitator Superfamily HV012_RS12115 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HV012_RS12120 ENOG4105BZU Histidine kinase HV012_RS12125 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV012_RS12130 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV012_RS12135 ENOG4105C5D exported protein HV012_RS12140 ENOG4105D5Q Arginine ornithine antiporter HV012_RS12150 ENOG4105RA2 Membrane HV012_RS12155 ENOG4107EXC regulatoR HV012_RS12160 ENOG4105JJR Histidine kinase HV012_RS12170 ENOG4105C9Q fumarate hydratase class II HV012_RS12175 ENOG4107GFK fumarate HV012_RS12180 ENOG4105EIP mannose-6-phosphate isomerase HV012_RS12185 ENOG4106J39 exported protein HV012_RS12190 ENOG4105C87 Aminotransferase class I and II HV012_RS12200 ENOG4105D9R oxidoreductase HV012_RS12205 ENOG4106C6R beta-lactam resistance protein HV012_RS12210 ENOG4105QZ5 OriC-binding nucleoid-associated protein HV012_RS12215 ENOG4105M9B inner membrane protein ydgK HV012_RS12240 ENOG4108UQQ Electron transport complex HV012_RS12250 ENOG4105CSM endonuclease III HV012_RS12255 ENOG4105DUX Transporter HV012_RS12260 ENOG4108K3A Glutathione S-transferase HV012_RS12265 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV012_RS12280 ENOG410642K Lysozyme inhibitor HV012_RS12290 ENOG4108XTF Outer Membrane Lipoprotein HV012_RS12305 ENOG4105Y49 secretion protein, HlyD family HV012_RS12310 ENOG4105DSW Fusaric acid resistance protein HV012_RS12315 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV012_RS12320 ENOG4107RGM aldo keto reductase HV012_RS12325 ENOG4105XZD Fe-S protein HV012_RS12330 ENOG4108WUH Transcriptional regulator, TetR family HV012_RS12335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV012_RS12340 ENOG4108UYE Lactoylglutathione lyase HV012_RS12345 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HV012_RS12350 ENOG4107QRT dEAD DEAH box helicase HV012_RS12355 ENOG4105M2J Glutaredoxin HV012_RS12360 ENOG4105K4H Nlp p60 protein HV012_RS12365 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV012_RS12370 ENOG4105F27 Major Facilitator HV012_RS12385 ENOG4105F52 Transcriptional regulator HV012_RS12390 ENOG4105CZQ inner membrane transport protein YdhC HV012_RS12395 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV012_RS12400 ENOG4108R6K riboflavin synthase, subunit alpha HV012_RS12490 ENOG4106V8H Nucleoid-associated protein HV012_RS12530 ENOG4105CF2 Mu-like prophage FluMu protein GP28 HV012_RS12540 ENOG4108QUU Morphogenesis Protein HV012_RS12545 ENOG4107XYH virion morphogenesis protein HV012_RS12640 ENOG4108X9F tail fiber protein HV012_RS12645 ENOG4105PTU response to oxidative stress HV012_RS12660 ENOG4105N0V mono-oxygenase ydhR HV012_RS12665 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HV012_RS12670 ENOG4105RFR Protein of unknown function (DUF2767) HV012_RS12675 ENOG4105CA9 Pyruvate kinase HV012_RS12680 ENOG4105KMX major outer membrane lipoprotein HV012_RS12685 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV012_RS12700 ENOG4105JRK feS assembly protein SufD HV012_RS12705 ENOG4105C3K feS assembly ATPase SufC HV012_RS12710 ENOG4105DIW FeS assembly protein SUFB HV012_RS12715 ENOG4108Z4V iron-sulfur cluster assembly HV012_RS12720 ENOG410671Z uncharacterized protein ydiH HV012_RS12725 ENOG4105KA0 thioesterase Superfamily protein HV012_RS12730 ENOG4105CQB FAD linked oxidase domain protein HV012_RS12735 ENOG4105IPI Membrane HV012_RS12745 ENOG4105SUA Ydil protein HV012_RS12750 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HV012_RS12760 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV012_RS12780 ENOG4108QBX (LipO)protein HV012_RS12785 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HV012_RS12820 ENOG41082NX 50s ribosomal protein l35 HV012_RS12825 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HV012_RS12840 ENOG4108NE3 Salt-induced outer membrane protein HV012_RS12845 ENOG4105DE4 1-phosphofructokinase HV012_RS12850 ENOG4105P10 Uncharacterized protein ydiZ HV012_RS12860 ENOG4107PN8 YfeABCD locus regulator HV012_RS12865 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV012_RS12870 ENOG4107K5X Membrane-bound metal-dependent hydrolase HV012_RS12875 ENOG4108ETY sodium dicarboxylate symporter HV012_RS12880 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HV012_RS12885 ENOG4105CH6 catalase HV012_RS12895 ENOG4105F8D glycoside hydrolase family 4 HV012_RS12900 ENOG4105EZV Transcriptional regulator HV012_RS12905 ENOG4105VCP PTS System HV012_RS12910 ENOG4105CK1 PTS System HV012_RS12915 ENOG4105VZJ PTS System HV012_RS12920 ENOG4105KKI DNA-binding transcriptional activator OsmE HV012_RS12930 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HV012_RS12940 ENOG4108SPG Periplasmic Protein HV012_RS12955 ENOG4105C26 Dehydrogenase HV012_RS12970 ENOG4105CGK Exodeoxyribonuclease III HV012_RS12975 ENOG4108RSN SNARE associated Golgi HV012_RS12980 ENOG4108N5C SNARE associated Golgi protein-related protein HV012_RS12985 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV012_RS12990 ENOG4105VNH ABC transporter solute-binding protein HV012_RS12995 ENOG4105CXZ ABC transporter, permease HV012_RS13000 ENOG4108VGW abc transporter atp-binding protein HV012_RS13005 ENOG4107RM6 sulfurtransferase HV012_RS13010 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HV012_RS13015 ENOG4105M6F mutator MutT protein HV012_RS13020 ENOG4105MTM Protein of unknown function (DUF1496) HV012_RS13025 ENOG4105D82 Glutamate dehydrogenase HV012_RS13035 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV012_RS13040 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HV012_RS13045 ENOG41069NU Nitroreductase HV012_RS13050 ENOG4105D07 Signal peptide peptidase, SppA HV012_RS13060 ENOG4105HDK L-asparaginase HV012_RS13065 ENOG4108RWI nicotinamidase HV012_RS13070 ENOG4105VUT cytoplasmic protein HV012_RS13085 ENOG4105DSB aldose 1-epimerase HV012_RS13105 ENOG4105D38 putrescine abc transporter HV012_RS13110 ENOG4107RUE extracellular solute-binding protein family 1 HV012_RS13125 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HV012_RS13135 ENOG4105D60 lipoprotein releasing system transmembrane protein HV012_RS13140 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV012_RS13145 ENOG4105D60 lipoprotein releasing system transmembrane protein HV012_RS13150 ENOG4105IQC Inner membrane protein YcfT HV012_RS13155 ENOG4108JA2 transcriptioN-repair coupling factor HV012_RS13160 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV012_RS13165 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HV012_RS13170 ENOG4105CEY Amp-dependent synthetase and ligase HV012_RS13175 ENOG4105Y4Z Outer Membrane Lipoprotein HV012_RS13180 ENOG41072GX Peptidase M22 Glycoprotease HV012_RS13185 ENOG4105DVT helicase HV012_RS13200 ENOG4105M4H endoribonuclease L-psp HV012_RS13205 ENOG4105V2F Uncharacterized protein yoac HV012_RS13225 ENOG4105CRQ synthase (Component I) HV012_RS13235 ENOG4105EJQ L-serine dehydratase HV012_RS13240 ENOG4107XTP (EAL) domain protein HV012_RS13245 ENOG4105EE5 Membrane protein terC HV012_RS13250 ENOG4105DAS pts system HV012_RS13255 ENOG4105ETZ PTS System HV012_RS13260 ENOG4105F3R pts system mannose fructose sorbose family iid HV012_RS13275 ENOG4105DHI Methyltransferase HV012_RS13290 ENOG4105Q3Y exported protein HV012_RS13300 ENOG4105TIK HV012_RS13305 ENOG4105J4Q Transcriptional regulator HV012_RS13310 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV012_RS13320 ENOG4105CN1 protease HV012_RS13330 ENOG4108ZGC gaf domain protein HV012_RS13335 ENOG4105H2K paraquat-inducible protein a HV012_RS13340 ENOG4105DY2 Paraquat-inducible protein b HV012_RS13350 ENOG4105WT8 Protein of unknown function (DUF1480) HV012_RS13355 ENOG4105UVW uncharacterized protein yebW HV012_RS13360 ENOG4108R1E Serine threonine protein phosphatase 1 HV012_RS13365 ENOG4105NKT exported protein HV012_RS13370 ENOG4108PNC copper resistance HV012_RS13375 ENOG4105FXM Copper resistance protein HV012_RS13380 ENOG4105MPK DNA polymerase III subunit theta HV012_RS13385 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV012_RS13390 ENOG4105UMD exodeoxyribonuclease X HV012_RS13395 ENOG4105CUG Oligopeptidase b HV012_RS13400 ENOG4108Q2J Inner membrane protein YebE HV012_RS13410 ENOG4105X2V dna damage-inducible protein HV012_RS13415 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HV012_RS13420 ENOG4108UHU Aldolase HV012_RS13425 ENOG4105C01 Dihydroxy-acid dehydratase HV012_RS13430 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HV012_RS13435 ENOG4106KNT transcriptional regulator HV012_RS13440 ENOG4105CA9 Pyruvate kinase HV012_RS13445 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV012_RS13450 ENOG4105DR5 peptidase HV012_RS13455 ENOG4105NXV High-affinity zinc uptake system protein HV012_RS13465 ENOG4105FAV ABC, transporter HV012_RS13485 ENOG4107S01 Repressor protein MetJ HV012_RS13495 ENOG4105CDY transcriptional regulatory protein HV012_RS13500 ENOG4108TIT dATP pyrophosphohydrolase HV012_RS13510 ENOG4105D3W isochorismatase HV012_RS13515 ENOG41081XQ Conserved Protein HV012_RS13520 ENOG4107TII Recombinase HV012_RS13580 ENOG41081XQ Conserved Protein HV012_RS13585 ENOG4105WJG Glutathione HV012_RS13605 ENOG4106ZCM YecM protein HV012_RS13615 ENOG4105W13 flagellar protein HV012_RS13620 ENOG4105D7B Flagellar biosynthesis protein flha HV012_RS13625 ENOG4105D00 flagellar biosynthetic protein flhB HV012_RS13635 ENOG4108J2R molybdopterin oxidoreductase HV012_RS13640 ENOG4105CUW cytochrome C-TYPE protein HV012_RS13645 ENOG4106WF9 DNA-binding transcriptional regulator TorR HV012_RS13650 ENOG4108SV3 Tmao reductase system periplasmic protein tort HV012_RS13655 ENOG4105BZU Histidine kinase HV012_RS13670 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV012_RS13675 ENOG4105C4M (Ubiquinol oxidase) subunit I HV012_RS13680 ENOG4107SVH Potassium channel protein HV012_RS13710 ENOG4105WH1 Two component transcriptional regulator luxr family HV012_RS13715 ENOG4105XVG cytoplasmic protein HV012_RS13720 ENOG4105VJY transcriptional regulator HV012_RS13725 ENOG4105CDA abc transporter atp-binding protein HV012_RS13730 ENOG4105E5Q amino acid AbC transporter HV012_RS13740 ENOG4105EAB amino acid AbC transporter HV012_RS13745 ENOG4108M9K flagella biosynthesis protein FliZ HV012_RS13750 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV012_RS13760 ENOG4105DTS flagellar hook-associated HV012_RS13765 ENOG4105MQ3 flagellar protein FliS HV012_RS13770 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HV012_RS13775 ENOG4105E5K Alpha-amylase HV012_RS13780 ENOG4108W9D (LipO)protein HV012_RS13785 ENOG41066VF YeeE YedE family protein HV012_RS13795 ENOG4107EEX Cellulose synthase regulator protein HV012_RS13800 ENOG4107QZ7 Cellulose synthase catalytic subunit HV012_RS13805 ENOG41064RH membrane protein YliF HV012_RS13810 ENOG4105BZU Histidine kinase HV012_RS13815 ENOG4108R86 Transcriptional regulator HV012_RS13820 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HV012_RS13830 ENOG4105XH3 HV012_RS13835 ENOG4105D6F Phosphatase HV012_RS13845 ENOG4105RQF LysR family Transcriptional regulator HV012_RS13850 ENOG4105MWK D-amino acid dehydrogenase, small subunit HV012_RS13875 ENOG4108VYJ response regulator receiver protein HV012_RS13885 ENOG4105BZU Histidine kinase HV012_RS13890 ENOG4105C8Q Methyl-accepting chemotaxis HV012_RS13920 ENOG4108V3W Chemotaxis protein, CheW HV012_RS13925 ENOG4105CBS Chea signal transduction histidine kinase HV012_RS13930 ENOG4105ER2 Ompa motb domain protein HV012_RS13935 ENOG4107RD7 Flagellar Motor Protein, MotA HV012_RS13940 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HV012_RS13950 ENOG4108VA4 Universal stress protein HV012_RS13960 ENOG4108K4C ec 3.1.3.12 HV012_RS13965 ENOG4105CNN ABC, transporter HV012_RS13970 ENOG4105C2J ABC transporter HV012_RS13975 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HV012_RS13980 ENOG4108UEC Ferritin-like protein HV012_RS13985 ENOG4105P23 (LipO)protein HV012_RS13990 ENOG41090A1 ferritin HV012_RS13995 ENOG4105VVZ metal-binding protein HV012_RS14000 ENOG4105E0U tyrosine-specific transport protein HV012_RS14005 ENOG4106RHG Yeca family HV012_RS14010 ENOG4105MVP hydrogenase-1 operon protein HyaF HV012_RS14015 ENOG4108VXY Hydrogenase-1 operon protein HyaE HV012_RS14020 ENOG4108USZ hydrogenase HV012_RS14025 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HV012_RS14030 ENOG4105DPX Hydrogenase, large subunit HV012_RS14035 ENOG4105E3S small subunit HV012_RS14050 ENOG4108MN8 Membrane HV012_RS14055 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HV012_RS14060 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HV012_RS14075 ENOG4105K4P CoA-binding domain protein HV012_RS14090 ENOG41088T4 Helicase IV HV012_RS14095 ENOG410901E Membrane HV012_RS14100 ENOG4105EM2 membrane HV012_RS14125 ENOG4105DAN ATP-dependent protease HV012_RS14135 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HV012_RS14140 ENOG4108Q2G (LipO)protein HV012_RS14145 ENOG4105DY2 Paraquat-inducible protein b HV012_RS14150 ENOG4105F1S paraquat-inducible protein a HV012_RS14155 ENOG4105C5H ABC transporter HV012_RS14165 ENOG4105QVC MOSC domain-containing protein HV012_RS14170 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HV012_RS14180 ENOG4108UZX fmn reductase HV012_RS14185 ENOG4105GVF (ABC) transporter HV012_RS14195 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV012_RS14200 ENOG4105E2Y ABC, transporter HV012_RS14205 ENOG4105CD8 aminopeptidase N HV012_RS14230 ENOG4105CGF Aromatic amino acid aminotransferase HV012_RS14235 ENOG4105C5X domain protein HV012_RS14240 ENOG4105EAQ (twin-arginine translocation) pathway signal HV012_RS14245 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HV012_RS14255 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HV012_RS14265 ENOG4106371 Methyltransferase HV012_RS14270 ENOG4107S90 membrAne HV012_RS14275 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HV012_RS14290 ENOG4105T0Z Conserved Protein HV012_RS14300 ENOG4105BZ1 (ABC) transporter HV012_RS14305 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HV012_RS14315 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HV012_RS14335 ENOG4107VMU Membrane HV012_RS14340 ENOG4105DDY UPF0142 protein ycaO HV012_RS14345 ENOG4105TMB Formate nitrite transporter HV012_RS14350 ENOG4105C6N Formate acetyltransferase HV012_RS14355 ENOG4105F1A Pyruvate formate-lyase HV012_RS14365 ENOG4105E5D amino acid HV012_RS14375 ENOG4105CHJ isochorismatase hydrolase HV012_RS14385 ENOG4105D1H recombination factor protein RarA HV012_RS14395 ENOG4105CNU cell division protein FtsK HV012_RS14405 ENOG4105C3M thioredoxin reductase HV012_RS14410 ENOG4108JJ9 ABC, transporter HV012_RS14415 ENOG4108JJ8 (ABC) transporter HV012_RS14425 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HV012_RS14435 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV012_RS14445 ENOG4105VEQ Cold shock protein HV012_RS14455 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV012_RS14460 ENOG4108MJ5 VirK protein HV012_RS14465 ENOG4105CPB ATP-dependent endonuclease of the OLD family HV012_RS14470 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV012_RS14475 ENOG4105DWU Membrane HV012_RS14485 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV012_RS14495 ENOG4105C7K acetolactate synthase HV012_RS14500 ENOG4105C5W Aldolase HV012_RS14505 ENOG4105CGD Nad-dependent epimerase dehydratase HV012_RS14510 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV012_RS14515 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV012_RS14525 ENOG41064MM (LipO)protein HV012_RS14530 ENOG4105E5Z arginine transporter ATP-binding subunit HV012_RS14535 ENOG4106PMH Extracellular solute-binding protein family 3 HV012_RS14540 ENOG4105GBT ABC transporter HV012_RS14545 ENOG4105DMR ABC, transporter HV012_RS14550 ENOG4106TNF Periplasmic binding protein HV012_RS14560 ENOG4105RBQ inner membrane protein ybjO HV012_RS14565 ENOG4105D38 putrescine abc transporter HV012_RS14570 ENOG4105F38 ABC transporter, permease HV012_RS14575 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV012_RS14580 ENOG4107RUE extracellular solute-binding protein family 1 HV012_RS14585 ENOG4108RMJ sensory transduction regulator HV012_RS14595 ENOG4108DBC nitroreductase HV012_RS14600 ENOG4105GWF inner membrane protein YbjM HV012_RS14615 ENOG4108RFG Tetr family transcriptional regulator HV012_RS14620 ENOG4106UW1 Major Facilitator superfamily HV012_RS14625 ENOG4108HCJ Hydrolase HV012_RS14635 ENOG4107QF7 multi-drug HV012_RS14640 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV012_RS14645 ENOG4107FB0 transcriptional regulator DeoR family HV012_RS14650 ENOG4105DZ1 carboxypeptidase HV012_RS14655 ENOG4108TGY Glutathione S-transferase HV012_RS14660 ENOG4105D8V Glucose sorbosone dehydrogenase HV012_RS14665 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HV012_RS14675 ENOG41064RH membrane protein YliF HV012_RS14680 ENOG4105BZU Histidine kinase HV012_RS14690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV012_RS14695 ENOG4105DEF Extracellular solute-binding protein, family 5 HV012_RS14700 ENOG4108JQ6 ABC transporter HV012_RS14705 ENOG4105CVM Molybdenum cofactor synthesis domain protein HV012_RS14710 ENOG4105D06 uba thif-type nad fad binding protein HV012_RS14715 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV012_RS14720 ENOG4105F1A Pyruvate formate-lyase HV012_RS14730 ENOG4108HCJ Hydrolase HV012_RS14735 ENOG41072TH Protein of unknown function (DUF1479) HV012_RS14740 ENOG4105C5H ABC transporter HV012_RS14745 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV012_RS14750 ENOG4105F4P )-transporter HV012_RS14755 ENOG4105KST dependent repressor HV012_RS14765 ENOG4108I6E Sulfatase HV012_RS14770 ENOG4108T1M outer membrane protein x HV012_RS14775 ENOG4107AQZ Membrane HV012_RS14785 ENOG4107R0W ABC transporter HV012_RS14790 ENOG4105E5Q amino acid AbC transporter HV012_RS14795 ENOG4105CDA abc transporter atp-binding protein HV012_RS14805 ENOG4105IBP Cyclic peptide transporter HV012_RS14810 ENOG4105CF1 Alkylated DNA repair protein HV012_RS14815 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV012_RS14820 ENOG4105CJ2 (LipO)protein HV012_RS14825 ENOG4105FCK Membrane HV012_RS14830 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HV012_RS14835 ENOG41068CG regulatoR HV012_RS14840 ENOG4105BZU Histidine kinase HV012_RS14845 ENOG4105BZU Histidine kinase HV012_RS14850 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV012_RS14855 ENOG4107QP7 CoA-transferase subunit A HV012_RS14860 ENOG4107QNJ CoA-transferase subunit B HV012_RS14865 ENOG4105CRW Short chain fatty acid transporter HV012_RS14870 ENOG4105CHU acetyl-coa acetyltransferase HV012_RS14875 ENOG4105EDV vault protein HV012_RS14880 ENOG41081SK signal peptide protein HV012_RS14885 ENOG4107S52 alpha-2-macroglobulin domain protein HV012_RS14890 ENOG4108QJJ Protein of unknown function (DUF1175) HV012_RS14895 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HV012_RS14900 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV012_RS14910 ENOG4107GHC outer membrane autotransporter HV012_RS14915 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV012_RS14920 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV012_RS14925 ENOG4105XPH Ferredoxin HV012_RS14930 ENOG4105FQR PH-inducible protein involved in stress response HV012_RS14935 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HV012_RS14940 ENOG4105CXY transporter HV012_RS14945 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HV012_RS14955 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV012_RS14960 ENOG4105DNE Transposase HV012_RS14970 ENOG4108EWA cinA-like protein HV012_RS14975 ENOG4108UII YfaZ family HV012_RS15025 ENOG4106GZG polymyxin resistance protein B HV012_RS15030 ENOG4105CEY Amp-dependent synthetase and ligase HV012_RS15040 ENOG4108IPT Naphthoate synthase HV012_RS15055 ENOG4105E4F Isochorismate synthase HV012_RS15060 ENOG4105TNS Conserved Protein HV012_RS15065 ENOG4107YB6 acetyltransferase, (GNAT) family HV012_RS15080 ENOG4105CP2 von willebrand factor, type a HV012_RS15085 ENOG4105GDX Domain of unknown function (DUF1877) HV012_RS15095 ENOG4105ZD8 HV012_RS15105 ENOG4105C8S subunit m HV012_RS15110 ENOG4105D65 subunit l HV012_RS15120 ENOG4107UFS subunit j HV012_RS15140 ENOG4107QIZ NADH dehydrogenase HV012_RS15145 ENOG4105GKE subunit e HV012_RS15165 ENOG4107NQ8 LysR family Transcriptional regulator HV012_RS15175 ENOG4105CHM Aminotransferase HV012_RS15180 ENOG4105DK2 UPF0207 protein HV012_RS15185 ENOG4107QWE )-transporter HV012_RS15190 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HV012_RS15195 ENOG4105XWI UPF0304 protein HV012_RS15205 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV012_RS15210 ENOG4105C6K Malic enzyme HV012_RS15215 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HV012_RS15220 ENOG4108HHA Transketolase HV012_RS15225 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HV012_RS15235 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV012_RS15245 ENOG4105K2J Transcriptional regulator HV012_RS15250 ENOG4105PTV Nudix Hydrolase HV012_RS15255 ENOG4108RE9 Phosphodiesterase HV012_RS15260 ENOG4108SHQ Glutathione S-transferase HV012_RS15265 ENOG4105CYM Glutathione S-transferase HV012_RS15270 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HV012_RS15275 ENOG4105ECP epimerase HV012_RS15280 ENOG4105DNE Transposase HV012_RS15285 ENOG4108JEH abc transporter atp-binding protein HV012_RS15290 ENOG4106YG3 ABC transporter HV012_RS15295 ENOG4105DSP amino acid AbC transporter HV012_RS15300 ENOG4105E89 ABC transporter HV012_RS15305 ENOG4105E89 ABC transporter HV012_RS15310 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV012_RS15315 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HV012_RS15320 ENOG4105E96 Colicin v production protein HV012_RS15325 ENOG4108S3P Sporulation domain protein HV012_RS15330 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HV012_RS15340 ENOG4105DQR SNARE associated Golgi HV012_RS15350 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV012_RS15360 ENOG4106WZ1 flagella biosynthesis regulator HV012_RS15365 ENOG4105F9N Major Facilitator Superfamily HV012_RS15370 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV012_RS15375 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HV012_RS15380 ENOG4105MH2 YfcL protein HV012_RS15385 ENOG4108BPE -transporting atpase HV012_RS15390 ENOG4105EJ9 Membrane HV012_RS15395 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HV012_RS15400 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HV012_RS15420 ENOG4105US4 fimbrial-like protein yfcP HV012_RS15425 ENOG4105UGQ Fimbrial HV012_RS15430 ENOG4105NEV Fimbrial HV012_RS15435 ENOG4108FZ9 Chaperone HV012_RS15450 ENOG4108BY2 phosphohistidine phosphatase HV012_RS15465 ENOG4105KZW UPF0381 protein HV012_RS15470 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV012_RS15475 ENOG410903C (LipO)protein HV012_RS15480 ENOG4105S64 Formate nitrite transporter HV012_RS15490 ENOG4105DFP Integrase HV012_RS15500 ENOG4108I1J Integrase HV012_RS15505 ENOG4105NBR Pectinesterase HV012_RS15520 ENOG4108QHK Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway HV012_RS15535 ENOG4105NVB glycoside hydrolase, family 19 HV012_RS15555 ENOG4105HRS Antitermination protein HV012_RS15565 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HV012_RS15575 ENOG4108K4B hydrolase HV012_RS15585 ENOG4105E0C molybdate abc transporter HV012_RS15590 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HV012_RS15600 ENOG4105F4R Transcriptional regulator mode HV012_RS15605 ENOG4105DKW ABC transporter HV012_RS15610 ENOG4105CMR udp-glucose 4-epimerase HV012_RS15615 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HV012_RS15625 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HV012_RS15635 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV012_RS15640 ENOG4105JND homeobox protein HV012_RS15645 ENOG4105PGM cation diffusion facilitator family transporter HV012_RS15650 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV012_RS15655 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HV012_RS15695 ENOG4105UFD tol-pal system protein YbgF HV012_RS15700 ENOG4105KCK Peptidoglycan-associated lipoprotein HV012_RS15710 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV012_RS15720 ENOG4105E02 MotA TolQ exbB proton channel HV012_RS15725 ENOG4107YD3 Thioesterase HV012_RS15730 ENOG4105KJB cyd operon protein YbgE HV012_RS15740 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV012_RS15745 ENOG4105C4M (Ubiquinol oxidase) subunit I HV012_RS15750 ENOG4105C8I hydrolase, family 38 HV012_RS15755 ENOG4105DM4 PTS System HV012_RS15760 ENOG4105FDP GntR family transcriptional regulator HV012_RS15765 ENOG4107WFU Glutamate mutase subunit sigma HV012_RS15775 ENOG4105DJI Methylaspartate mutase, E subunit HV012_RS15800 ENOG4107GFK fumarate HV012_RS15805 ENOG4105ETT transcriptional Regulator, LysR family HV012_RS15810 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV012_RS15820 ENOG4105C7S Dehydrogenase HV012_RS15825 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV012_RS15830 ENOG4105E33 succinate dehydrogenase HV012_RS15835 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV012_RS15840 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HV012_RS15845 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HV012_RS15850 ENOG4105BZN citrate synthase HV012_RS15865 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV012_RS15875 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV012_RS15885 ENOG4105CTX dehydratase HV012_RS15895 ENOG4105CHR reductase HV012_RS15900 ENOG4105CPQ Dehydrogenase HV012_RS15905 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV012_RS15910 ENOG41073TP transcriptional regulator HV012_RS15915 ENOG4106UBK fimbrial-like adhesin protein HV012_RS15920 ENOG4106PG1 outer membrane usher protein HV012_RS15925 ENOG4108TTM chaperone HV012_RS15930 ENOG4108MY7 Fimbrial HV012_RS15935 ENOG4108KK1 membrane protein AbrB duplication HV012_RS15960 ENOG4107R7A Allophanate hydrolase subunit 2 HV012_RS15965 ENOG4105P4J Allophanate hydrolase, subunit 1 HV012_RS15970 ENOG4107QNR UPF0135 protein HV012_RS15975 ENOG4105DUX Transporter HV012_RS15980 ENOG4105CVP deoxyribo-dipyrimidine photolyase HV012_RS15985 ENOG4107SEY Conserved Protein HV012_RS15990 ENOG4105XIQ Protein of unknown function (DUF2517) HV012_RS16015 ENOG4105C08 Histidine kinase HV012_RS16020 ENOG4105EEX Two component transcriptional regulator (Winged helix family HV012_RS16030 ENOG4105D5Q Arginine ornithine antiporter HV012_RS16035 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV012_RS16040 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HV012_RS16045 ENOG4105EV9 Alpha Beta Hydrolase HV012_RS16050 ENOG4105NNH LexA regulated protein HV012_RS16055 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HV012_RS16065 ENOG41090R7 Ferric uptake HV012_RS16070 ENOG4105GX6 (LipO)protein HV012_RS16085 ENOG4105CI1 PTS System HV012_RS16095 ENOG4105CE4 GlcNAc 6-P deacetylase HV012_RS16100 ENOG4105E2R ROK family HV012_RS16105 ENOG4105D4U had-superfamily hydrolase, subfamily iia HV012_RS16110 ENOG4105CAQ asparagine synthetase HV012_RS16160 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV012_RS16170 ENOG4105C9A Phoh family HV012_RS16180 ENOG4108JU5 Magnesium and cobalt efflux protein HV012_RS16185 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HV012_RS16195 ENOG4107RP9 extracellular solute-binding protein, family 3 HV012_RS16200 ENOG4105EAD ABC transporter HV012_RS16205 ENOG4105DRP amino acid AbC transporter HV012_RS16210 ENOG4105CDA abc transporter atp-binding protein HV012_RS16230 ENOG4107PAI alpha helical protein HV012_RS16245 ENOG4105DJF DNA polymerase III, delta' subunit HV012_RS16255 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HV012_RS16265 ENOG4105CJN penicillin-binding protein HV012_RS16270 ENOG4105CNI cell division protein FtsW HV012_RS16275 ENOG4105K6T rare lipoprotein A HV012_RS16280 ENOG4105DZ1 carboxypeptidase HV012_RS16290 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HV012_RS16320 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HV012_RS16325 ENOG4105CEE C4-dicarboxylate transporter HV012_RS16330 ENOG4105KTS ribonuclease HV012_RS16335 ENOG4105NXH GreA GreB family elongation factor HV012_RS16340 ENOG4108U51 Universal stress protein HV012_RS16345 ENOG4108JU3 Alkyl hydroperoxide reductase HV012_RS16350 ENOG4105D3R alkyl hydroperoxide reductase HV012_RS16355 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HV012_RS16360 ENOG4105DQS Transcriptional regulator HV012_RS16365 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV012_RS16370 ENOG4105GTN ParB Domain Protein Nuclease HV012_RS16375 ENOG4105CHM Aminotransferase HV012_RS16380 ENOG4107SCQ Iron-containing alcohol dehydrogenase HV012_RS16385 ENOG4105VCD cytoplasmic protein HV012_RS16390 ENOG4105D22 carbon starvation protein HV012_RS16395 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HV012_RS16400 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV012_RS16405 ENOG4105WQI isochorismatase HV012_RS16410 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV012_RS16415 ENOG4105E4F Isochorismate synthase HV012_RS16420 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HV012_RS16430 ENOG4105DQ5 transport system permease protein HV012_RS16435 ENOG4105TVJ transport system, permease HV012_RS16440 ENOG4105E0A ABC, transporter HV012_RS16445 ENOG4108QY5 Ferric enterobactin transport protein HV012_RS16450 ENOG4105C0W non-ribosomal peptide synthetase HV012_RS16455 ENOG41085A6 mbth domain-containing protein HV012_RS16460 ENOG4105E93 esterase HV012_RS16465 ENOG4107RNH Outer membrane receptor FepA HV012_RS16470 ENOG4108TSE Transferase HV012_RS16490 ENOG4105WQ6 Membrane HV012_RS16495 ENOG4105MSB protein, conserved in bacteria HV012_RS16500 ENOG4108RCM Nitroreductase HV012_RS16505 ENOG4105CUY Mechanosensitive ion channel HV012_RS16510 ENOG4105C85 amino acid HV012_RS16515 ENOG4108IJF Heavy metal efflux pump, CzcA HV012_RS16520 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HV012_RS16525 ENOG410624V efflux system protein HV012_RS16530 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV012_RS16535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV012_RS16540 ENOG4105GR3 Histidine kinase HV012_RS16575 ENOG4107QMP dna polymerase iii subunits gamma and tau HV012_RS16585 ENOG4105WD1 Membrane HV012_RS16590 ENOG4108URS primosomal replication protein n'' HV012_RS16595 ENOG4106428 Protein of unknown function (DUF2496) HV012_RS16600 ENOG4105EGS Mechanosensitive ion channel HV012_RS16605 ENOG4107XI7 Tetr family transcriptional regulator HV012_RS16610 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV012_RS16615 ENOG4105BZS acriflavin resistance protein HV012_RS16620 ENOG4108UKR Biofilm formation regulator YbaJ HV012_RS16630 ENOG4105GSJ Inner membrane protein ylaC HV012_RS16635 ENOG41066DG (EAL) domain protein HV012_RS16640 ENOG4105KCV RNA signal recognition particle 4.5S RNA HV012_RS16650 ENOG41080UX Methyltransferase HV012_RS16655 ENOG4108MNP Glycoprotein polysaccharide metabolism HV012_RS16660 ENOG4105C29 acyl-CoA thioesterase HV012_RS16665 ENOG4105BZU Histidine kinase HV012_RS16670 ENOG4108YZA Nitrogen regulatory protein pii HV012_RS16675 ENOG4105BZ1 (ABC) transporter HV012_RS16680 ENOG4105BZ1 (ABC) transporter HV012_RS16685 ENOG4108XM1 transcriptional regulator AsnC family HV012_RS16695 ENOG4108NFA extracellular solute-binding protein HV012_RS16705 ENOG4108TGP Thioesterase superfamily protein HV012_RS16710 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HV012_RS16715 ENOG4105EIN peptidylprolyl cis-trans isomerase HV012_RS16720 ENOG4105K70 DNA-binding protein HV012_RS16725 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HV012_RS16745 ENOG4105M85 Bola protein HV012_RS16750 ENOG4105IEY (LipO)protein HV012_RS16755 ENOG4105EYM Major Facilitator superfamily HV012_RS16760 ENOG4105E2S oxidase) subunit II HV012_RS16765 ENOG4105BZ9 Cytochrome C oxidase, subunit I HV012_RS16770 ENOG4105CCU oxidase (Subunit III) HV012_RS16775 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HV012_RS16795 ENOG4107HP6 Transcriptional regulator HV012_RS16800 ENOG4107V59 shikimate HV012_RS16805 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HV012_RS16815 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HV012_RS16825 ENOG4105D2S major facilitator superfamily HV012_RS16830 ENOG4107RDB Major Facilitator HV012_RS16840 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HV012_RS16845 ENOG4107S0N DJ-1 family HV012_RS16850 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HV012_RS16860 ENOG4105CTB Polyprenyl synthetase HV012_RS16870 ENOG4105CPC Aldo Keto reductase HV012_RS16875 ENOG4108ZAI phosphatidylglycerophosphatase a HV012_RS16880 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HV012_RS16890 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HV012_RS16895 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HV012_RS16905 ENOG4108KIC (LipO)protein HV012_RS16910 ENOG4105DRB nucleoside-specific channel-forming protein HV012_RS16915 ENOG4105N1F Hnh endonuclease HV012_RS16920 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV012_RS16925 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV012_RS16930 ENOG4105VIE preprotein translocase, subunit YajC HV012_RS16950 ENOG4107R28 alpha amylase, catalytic region HV012_RS16955 ENOG4105C85 amino acid HV012_RS16960 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV012_RS16965 ENOG4105BZU Histidine kinase HV012_RS16975 ENOG4107RH8 nuclease SbcCD subunit D HV012_RS16980 ENOG4105EYH Exonuclease HV012_RS16985 ENOG4105DKQ ROK family HV012_RS17000 ENOG4105HBA AroM protein HV012_RS17010 ENOG4105SS3 HV012_RS17025 ENOG4105II7 pyrroline-5-carboxylate reductase HV012_RS17030 ENOG4105BZU Histidine kinase HV012_RS17035 ENOG4105VIF phosphate starvation-inducible protein HV012_RS17050 ENOG4105CPF Cell wall formation (By similarity) HV012_RS17055 ENOG4105UNH Membrane HV012_RS17060 ENOG4105FR5 inner membrane protein YaiY HV012_RS17065 ENOG4107QS8 (LipO)protein HV012_RS17070 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HV012_RS17075 ENOG4107R6D beta-lactam binding protein AmpH HV012_RS17080 ENOG4108PNB DNA-binding transcriptional regulator HV012_RS17100 ENOG4105D52 delta-aminolevulinic acid dehydratase HV012_RS17105 ENOG4105E2B Taurine dioxygenase HV012_RS17110 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HV012_RS17115 ENOG4108IY8 ABC, transporter HV012_RS17120 ENOG4106FTQ Taurine ABC transporter, periplasmic HV012_RS17125 ENOG4107W19 lmbE family HV012_RS17135 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV012_RS17140 ENOG4105DXD 2-methylcitrate dehydratase HV012_RS17145 ENOG4105BZN citrate synthase HV012_RS17150 ENOG4105CR4 methylisocitrate lyase HV012_RS17155 ENOG4108JU7 Transcriptional regulator HV012_RS17160 ENOG4105TDT uncharacterized protein yahO HV012_RS17165 ENOG4105E82 cytochrome subunit of dehydrogenase HV012_RS17170 ENOG4105BZU Histidine kinase HV012_RS17175 ENOG4105C6F GntR Family Transcriptional Regulator HV012_RS17180 ENOG4105CPQ Dehydrogenase HV012_RS17185 ENOG4108I5G Major Facilitator superfamily HV012_RS17190 ENOG4105BZU Histidine kinase HV012_RS17200 ENOG4105BZU Histidine kinase HV012_RS17205 ENOG4108HF7 Gcn5-related n-acetyltransferase HV012_RS17215 ENOG4107SET aldo keto reductase HV012_RS17220 ENOG4105EQ2 LysR family Transcriptional regulator HV012_RS17265 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV012_RS17280 ENOG4108YGG dna repair protein HV012_RS17285 ENOG4105MFG Antirestriction protein HV012_RS17290 ENOG4106H6R UPF0380 protein HV012_RS17295 ENOG4105F4K antigen 43 HV012_RS17315 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HV012_RS17320 ENOG4105C26 Dehydrogenase HV012_RS17325 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HV012_RS17340 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HV012_RS17345 ENOG4107QR9 Iron-sulfur cluster binding protein HV012_RS17350 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV012_RS17355 ENOG4108K01 transcriptional regulator HV012_RS17360 ENOG4107QN2 dihydrolipoyl dehydrogenase HV012_RS17365 ENOG41066GK UPF0379 protein ykgI HV012_RS17370 ENOG4108KBJ Inner membrane protein YkgB HV012_RS17415 ENOG4105C2X Arabinose 5-phosphate isomerase HV012_RS17420 ENOG4105ECX polysaccharide export HV012_RS17425 ENOG4107V1M polysaccharide export protein HV012_RS17430 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HV012_RS17435 ENOG4105E12 capsule polysaccharide HV012_RS17440 ENOG41084CK capsule polysaccharide HV012_RS17455 ENOG4108UW5 maltose o-acetyltransferase HV012_RS17460 ENOG4105D5D udp-galactopyranose mutase HV012_RS17465 ENOG4105K64 Glycosyl transferase, family 2 HV012_RS17485 ENOG41090SZ ABC-2 type transporter HV012_RS17510 ENOG4108P8R HV012_RS17515 ENOG4108P8R HV012_RS17550 ENOG4105FCK Membrane HV012_RS17570 ENOG4105CIN aminoacyl-histidine dipeptidase HV012_RS17585 ENOG4108S2Y peptide Chain Release factor HV012_RS17595 ENOG4108HYG acetyltransferase HV012_RS17615 ENOG4107QYX exodeoxyribonuclease v alpha HV012_RS17620 ENOG4107QKA exodeoxyribonuclease V beta HV012_RS17625 ENOG4107QXK peptidase HV012_RS17630 ENOG4105DSY exodeoxyribonuclease V, gamma HV012_RS17635 ENOG4105RVB Prepilin peptidase dependent protein c HV012_RS17640 ENOG4105SEN Protein of unknown function (DUF2509) HV012_RS17645 ENOG4105JCS prepilin peptidase dependent protein HV012_RS17650 ENOG4105IPU prepilin peptidase dependent protein A HV012_RS17665 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HV012_RS17680 ENOG4105EE5 Membrane protein terC HV012_RS17685 ENOG4105SUV lipoprotein YgdR HV012_RS17690 ENOG4105CPC Aldo Keto reductase HV012_RS17715 ENOG41060NJ transcriptional regulator HV012_RS17725 ENOG4105RQF LysR family Transcriptional regulator HV012_RS17730 ENOG4105CHU acetyl-coa acetyltransferase HV012_RS17735 ENOG4108MHD transport protein HV012_RS17740 ENOG4105ISV protein with bipartite regulator domain HV012_RS17745 ENOG4108TC1 Transcriptional regulator HV012_RS17755 ENOG410802X bacteriophage n4 adsorption protein b HV012_RS17760 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HV012_RS17765 ENOG4105QUW HV012_RS17770 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HV012_RS17775 ENOG4105DZC cytosine deaminase HV012_RS17820 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HV012_RS17850 ENOG4106YSC HV012_RS17865 ENOG4105XB7 anti-repressor protein HV012_RS17885 ENOG4105DFP Integrase HV012_RS17895 ENOG4108K5P (LipO)protein HV012_RS17900 ENOG4105MP9 class II Aldolase HV012_RS17920 ENOG4105C5Q Transcriptional regulator HV012_RS17925 ENOG4105H3G oxidoreductase HV012_RS17930 ENOG4105KME endoribonuclease L-psp HV012_RS17940 ENOG4105CWC Acetylornithine deacetylase HV012_RS17945 ENOG4105CVK Glutamate decarboxylase HV012_RS17950 ENOG4105CSV Glutaminase HV012_RS17955 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HV012_RS17960 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HV012_RS17965 ENOG4105C7W Xanthine dehydrogenase HV012_RS17970 ENOG4107XAN XdhC and CoxI family HV012_RS17985 ENOG4105CRK lysyL-tRNA synthetase HV012_RS17995 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HV012_RS18000 ENOG4105T95 Thiol disulfide interChange protein HV012_RS18005 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV012_RS18010 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HV012_RS18015 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HV012_RS18020 ENOG4105Y75 tpr repeat protein HV012_RS18030 ENOG4108UT2 hemolysin iii HV012_RS18040 ENOG4105CS2 ec 3.2.1.21 HV012_RS18070 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV012_RS18075 ENOG4105D0A hydroxylase HV012_RS18080 ENOG4107RAQ aminopeptidase HV012_RS18100 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HV012_RS18110 ENOG4108JQ1 Dehydrogenase HV012_RS18125 ENOG4105MPN Membrane HV012_RS18130 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HV012_RS18145 ENOG4105D64 Mechanosensitive ion channel HV012_RS18150 ENOG4105D2N Aldolase HV012_RS18165 ENOG4107Z1W Fructose transport system kinase HV012_RS18170 ENOG4108R4K DNA-binding, transcriptional regulator HV012_RS18175 ENOG4108Q8A Fructose-1,6-bisphosphatase HV012_RS18180 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV012_RS18185 ENOG4105CTS PTS system mannitol-specific HV012_RS18190 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV012_RS18195 ENOG4105EPW hflc protein HV012_RS18200 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV012_RS18205 ENOG4108K0D peptidase, M48 HV012_RS18220 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HV012_RS18245 ENOG4107QNK )-transporter HV012_RS18255 ENOG4105RWS endonuclease I HV012_RS18260 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HV012_RS18265 ENOG4105D7Z glutathione synthase HV012_RS18280 ENOG4105CZX twitching motility protein HV012_RS18285 ENOG4105DFA alanine racemase domain protein HV012_RS18290 ENOG4108VIA integral membrane protein HV012_RS18300 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV012_RS18305 ENOG4105CSA Coproporphyrinogen iii oxidase HV012_RS18310 ENOG4106MH3 alpha helix chain HV012_RS18315 ENOG4105HDK L-asparaginase HV012_RS18320 ENOG4105K33 Periplasmic Protein HV012_RS18325 ENOG41090ED Protein with unknown function (DUF469) HV012_RS18335 ENOG4105CEN a g-specific adenine glycosylase HV012_RS18350 ENOG4105EAA nucleoside HV012_RS18360 ENOG4108UQV Membrane HV012_RS18400 ENOG4107QHF type ii secretion system protein e HV012_RS18410 ENOG4108VAU general secretion pathway protein G HV012_RS18420 ENOG4105X5Z General secretion pathway protein I HV012_RS18440 ENOG4105U1E general secretion pathway protein M HV012_RS18445 ENOG410600K aminopeptidase HV012_RS18450 ENOG4106032 Glutathionylspermidine synthase HV012_RS18460 ENOG4105CYM Glutathione S-transferase HV012_RS18465 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HV012_RS18475 ENOG4108WGS hydrogenase 2-specific chaperone HV012_RS18480 ENOG4108USZ hydrogenase HV012_RS18485 ENOG4105DPX Hydrogenase, large subunit HV012_RS18490 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HV012_RS18495 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV012_RS18500 ENOG4105E3S small subunit HV012_RS18505 ENOG410900S Protein of unknown function (DUF2623) HV012_RS18515 ENOG4105CPC Aldo Keto reductase HV012_RS18525 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV012_RS18530 ENOG4108ZZF transport protein (ExbD) HV012_RS18535 ENOG4105CWK Biopolymer transport protein, ExbB HV012_RS18540 ENOG4105C28 cystathionine HV012_RS18545 ENOG4108K81 inner membrane protein YghB HV012_RS18550 ENOG4105CF7 AraC family transcriptional regulator HV012_RS18555 ENOG4108I6A alcohol dehydrogenase HV012_RS18560 ENOG4105CV8 reductase HV012_RS18565 ENOG4107QPK )-transporter HV012_RS18575 ENOG4105CCT upf0313 protein HV012_RS18580 ENOG4107YCY Transcriptional regulator HV012_RS18585 ENOG4105DEI Mannitol dehydrogenase HV012_RS18590 ENOG4105CPQ Dehydrogenase HV012_RS18595 ENOG4105DG4 malate L-lactate dehydrogenase HV012_RS18600 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV012_RS18610 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV012_RS18615 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HV012_RS18620 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HV012_RS18625 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV012_RS18630 ENOG4108J59 Extracellular solute-binding protein, family 5 HV012_RS18635 ENOG4105F4I Transcriptional regulator HV012_RS18640 ENOG4105H4F exported protein HV012_RS18645 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV012_RS18650 ENOG4105DHQ Histidine kinase HV012_RS18655 ENOG4105NF4 modulator of drug activity HV012_RS18660 ENOG4105VRH Antibiotic biosynthesis monooxygenase HV012_RS18665 ENOG4106KNT transcriptional regulator HV012_RS18675 ENOG4105EHG Permease protein HV012_RS18680 ENOG4105DQ5 transport system permease protein HV012_RS18685 ENOG4105E0A ABC, transporter HV012_RS18695 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV012_RS18700 ENOG4105IPS esterase HV012_RS18705 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV012_RS18710 ENOG4108SX3 cytoplasmic protein HV012_RS18715 ENOG41087AY ADP-Ribose pyrophosphatase HV012_RS18720 ENOG4105DFG type I secretion outer membrane protein HV012_RS18730 ENOG4106032 Glutathionylspermidine synthase HV012_RS18735 ENOG4108MR7 Arylsulfotransferase HV012_RS18740 ENOG4108N92 Thiol disulfide Interchange Protein HV012_RS18750 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HV012_RS18775 ENOG4108TTM chaperone HV012_RS18780 ENOG4108MY7 Fimbrial HV012_RS18790 ENOG4105W0Z cytoplasmic protein HV012_RS18800 ENOG4105PV3 Inner membrane protein yqiJ HV012_RS18805 ENOG4107S78 Band 7 protein HV012_RS18825 ENOG4105I7R Adenylate cyclase HV012_RS18830 ENOG4106MWK domain protein HV012_RS18845 ENOG4107ZVW dihydroneopterin aldolase HV012_RS18855 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV012_RS18865 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HV012_RS18870 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV012_RS18890 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV012_RS18930 ENOG41080XV Thioredoxin HV012_RS18940 ENOG4105Q26 Siderophore-interacting protein HV012_RS18945 ENOG4105NTW Transcriptional regulator HV012_RS18950 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV012_RS18960 ENOG4105CBP Major Facilitator HV012_RS18970 ENOG4105C6F GntR Family Transcriptional Regulator HV012_RS18975 ENOG4105DEI Mannitol dehydrogenase HV012_RS18985 ENOG4105Y4Z Outer Membrane Lipoprotein HV012_RS18995 ENOG4105KT7 mgtC SapB transporter HV012_RS19000 ENOG4105XXV Acid-resistance protein HV012_RS19005 ENOG41060V2 Acid-resistance protein HV012_RS19010 ENOG4108YK4 Acid-resistance membrane protein HV012_RS19015 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HV012_RS19020 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV012_RS19025 ENOG4105BZS acriflavin resistance protein HV012_RS19035 ENOG4108NKV transcriptional regulator HV012_RS19040 ENOG4105D6F Phosphatase HV012_RS19055 ENOG4106D80 Uncharacterized protein YhaL HV012_RS19070 ENOG4105C7B Threonine dehydratase HV012_RS19075 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HV012_RS19080 ENOG4105CIZ coA-substrate-specific enzyme activase HV012_RS19090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV012_RS19095 ENOG4105C8Q Methyl-accepting chemotaxis HV012_RS19105 ENOG4108IA2 Sodium pantothenate symporter HV012_RS19125 ENOG4108V8F Transcriptional regulator, MarR family HV012_RS19130 ENOG4105ERH Fumarylacetoacetate hydrolase HV012_RS19135 ENOG4105C26 Dehydrogenase HV012_RS19140 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HV012_RS19170 ENOG4105EFA 4-hydroxyphenylacetate HV012_RS19175 ENOG4107UWN reductase HV012_RS19180 ENOG4105D22 carbon starvation protein HV012_RS19185 ENOG4105VCD cytoplasmic protein HV012_RS19190 ENOG4105CKI cobalamin synthesis protein HV012_RS19200 ENOG4106DIZ Domain of unknown function (DUF1127) HV012_RS19205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV012_RS19215 ENOG41083G8 Multidrug resistance protein MdtM HV012_RS19220 ENOG4106BRA Membrane HV012_RS19250 ENOG4105C0D helicase HV012_RS19260 ENOG4105DQ4 alcohol dehydrogenase HV012_RS19265 ENOG4105D7A ATP-binding protein HV012_RS19270 ENOG4107S21 permease HV012_RS19275 ENOG4105K4T epimerase HV012_RS19280 ENOG4107R7Y intracellular protease Pfpi family HV012_RS19295 ENOG4108YYD acetyltransferase HV012_RS19315 ENOG4105DEN Luciferase family HV012_RS19365 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HV012_RS19390 ENOG4108K70 Transcriptional regulator HV012_RS19395 ENOG4105CIC tryptophan-specific transport protein HV012_RS19400 ENOG4105C1J atp-dependent rna helicase HV012_RS19440 ENOG4105CHV Transcription elongation factor NusA HV012_RS19460 ENOG4105DIJ Phosphoethanolamine transferase HV012_RS19470 ENOG4105NTZ Preprotein translocase subunit SecG HV012_RS19480 ENOG4105EEI dihydropteroate synthase HV012_RS19485 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV012_RS19495 ENOG4105HBR Rna-binding protein HV012_RS19500 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HV012_RS19505 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HV012_RS19515 ENOG4105QYV Membrane HV012_RS19530 ENOG4105EAH synthase HV012_RS19535 ENOG4105HVQ Regulatory factor of maltose metabolism HV012_RS19545 ENOG4105VFK BolA family HV012_RS19550 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HV012_RS19555 ENOG4105E3I toluene tolerance HV012_RS19560 ENOG4107PE3 Mammalian cell entry related domain protein HV012_RS19565 ENOG4105CY3 ABC transporter, permease HV012_RS19570 ENOG4105DHJ ABC, transporter HV012_RS19575 ENOG4105FEU K -dependent Na -Ca exchanger HV012_RS19580 ENOG4105C2X Arabinose 5-phosphate isomerase HV012_RS19590 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HV012_RS19595 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HV012_RS19600 ENOG4108IUZ ABC transporter HV012_RS19605 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV012_RS19610 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HV012_RS19615 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HV012_RS19625 ENOG41080Z8 PHOSPHOCARRIER protein HV012_RS19630 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HV012_RS19640 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HV012_RS19645 ENOG4105BZU Histidine kinase HV012_RS19650 ENOG4105N5T Radical SAM Protein HV012_RS19655 ENOG4105CBC glutamate synthase HV012_RS19660 ENOG4105BZ8 glutamate synthase HV012_RS19665 ENOG4105DFS Conserved Protein HV012_RS19670 ENOG4108R66 Conserved Protein HV012_RS19685 ENOG4105JHE Major Facilitator Superfamily HV012_RS19700 ENOG4105KB2 stringent starvation protein b HV012_RS19705 ENOG4107MKT Stringent starvation protein a HV012_RS19720 ENOG4105D6Z AFG1 family ATPase HV012_RS19725 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HV012_RS19730 ENOG4105C0H protease HV012_RS19735 ENOG4105C0H protease HV012_RS19745 ENOG4107GFK fumarate HV012_RS19750 ENOG4106DSS Tartrate dehydratase subunit alpha HV012_RS19755 ENOG4105C8P )-transporter HV012_RS19765 ENOG4105G3Z GntR family transcriptional regulator HV012_RS19780 ENOG4105RID UPF0379 protein yhcN HV012_RS19785 ENOG4105UNR (Barnase) inhibitor HV012_RS19800 ENOG4105ZQC membrane protein AaeX HV012_RS19805 ENOG4105CR8 Transcriptional regulator HV012_RS19810 ENOG4105D1U peptidase U62 modulator of DNA gyrase HV012_RS19815 ENOG4105QD6 exported protein HV012_RS19820 ENOG4105C03 ribonuclease HV012_RS19830 ENOG4105VQ7 Rod shape-determining protein MreD HV012_RS19835 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HV012_RS19845 ENOG41062P1 Diguanylate cyclase phosphodiesterase HV012_RS19850 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV012_RS19865 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HV012_RS19870 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV012_RS19875 ENOG4105RG0 Membrane HV012_RS19880 ENOG4108IA2 Sodium pantothenate symporter HV012_RS19890 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV012_RS19900 ENOG4105CEC DNA methylase N-4 N-6 HV012_RS19905 ENOG41061ME transport protein HV012_RS19910 ENOG4108XG4 DNA-binding transcriptional regulator HV012_RS19915 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV012_RS19925 ENOG4105XCM membrane LIPOPROTEIN HV012_RS19935 ENOG4105EZ7 amino acid ABC transporter HV012_RS19940 ENOG4105DRP amino acid AbC transporter HV012_RS19945 ENOG4105CDA abc transporter atp-binding protein HV012_RS19985 ENOG4108Z0R Transferase HV012_RS19990 ENOG4105SG3 Protein of unknown function (DUF1488) HV012_RS20005 ENOG4108WI1 Dna topoisomerase HV012_RS20015 ENOG4105C79 DNA protecting protein DprA HV012_RS20035 ENOG4105C1A potassium transporter peripheral membrane HV012_RS20045 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HV012_RS20050 ENOG4105W1Y Transcriptional regulator HV012_RS20055 ENOG4105VTS DnaJ-like, subfamily C HV012_RS20085 ENOG41067V7 50S ribosomal protein L36 HV012_RS20090 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HV012_RS20135 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HV012_RS20180 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HV012_RS20205 ENOG4108UQY Iron-storage protein HV012_RS20210 ENOG4105W53 bacterioferritin-associated ferredoxin HV012_RS20240 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV012_RS20250 ENOG4105WWK YheO domain protein HV012_RS20255 ENOG4108V1T peptidylprolyl cis-trans isomerase HV012_RS20265 ENOG4108YZY peptidylprolyl cis-trans isomerase HV012_RS20270 ENOG4105VKU nucleicacid-binding protein HV012_RS20285 ENOG4105C5H ABC transporter HV012_RS20290 ENOG4105DNZ Alpha Beta Hydrolase HV012_RS20300 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HV012_RS20305 ENOG4108UKZ OsmC family HV012_RS20315 ENOG410613R integral membrane protein, YccS YhfK family HV012_RS20320 ENOG4105C8Y Acetylornithine aminotransferase HV012_RS20325 ENOG4105DDQ anthranilate synthase HV012_RS20330 ENOG4105MZU cell filamentation protein HV012_RS20340 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV012_RS20345 ENOG4107QZF nitrite reductase NADPH large subunit HV012_RS20350 ENOG4105WZK nitrite reductase NADPH small subunit HV012_RS20355 ENOG4107V9H nitrite transporter HV012_RS20365 ENOG4105VYH HV012_RS20370 ENOG4106PKC pyridoxal phosphate binding HV012_RS20375 ENOG4106M0N transport system permease protein HV012_RS20380 ENOG4105MUZ Protein of unknown function DUF2620 HV012_RS20385 ENOG41080QX K07048 phosphotriesterase-related protein HV012_RS20390 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HV012_RS20395 ENOG4108626 Racemase HV012_RS20400 ENOG4105RMW regulation of transcription, DNA-dependent HV012_RS20405 ENOG4108M21 HV012_RS20410 ENOG4105C31 Tryptophanyl-tRNA synthetase HV012_RS20415 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HV012_RS20420 ENOG4105DJV ribulose-phosphate 3-epimerase HV012_RS20425 ENOG4105DFE Dna adenine methylase HV012_RS20430 ENOG4105EGB membrane protein DamX HV012_RS20445 ENOG4105E4G Type IV pilus HV012_RS20450 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HV012_RS20455 ENOG4105XPX DNA utilization protein HofO HV012_RS20460 ENOG41065NF Fimbrial assembly family protein HV012_RS20465 ENOG4108U1Q Pilus assembly protein HV012_RS20470 ENOG4108JQC penicillin-binding protein 1A HV012_RS20475 ENOG4107RK2 ADP-ribose diphosphatase NudE HV012_RS20480 ENOG4105DQY intracellular growth attenuator HV012_RS20485 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HV012_RS20490 ENOG4105VEJ Heat shock protein HV012_RS20500 ENOG4108MAJ Membrane HV012_RS20525 ENOG4105E0F Histidine kinase HV012_RS20535 ENOG4108RRZ Transcription elongation factor GreB HV012_RS20540 ENOG4105BZM domain protein HV012_RS20545 ENOG4105XFK Ferrous iron transport protein A HV012_RS20550 ENOG4105CE1 Ferrous iron transport protein b HV012_RS20560 ENOG4105DNE Transposase HV012_RS20570 ENOG4105MJ2 Competence protein HV012_RS20580 ENOG4105C6Z Gluconate HV012_RS20585 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HV012_RS20590 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV012_RS20600 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HV012_RS20605 ENOG4105E0Y RtcB Protein HV012_RS20610 ENOG4105CYB regulatoR HV012_RS20615 ENOG4105E98 transcriptional regulator DeoR family HV012_RS20630 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV012_RS20645 ENOG4105CVA phosphate HV012_RS20650 ENOG4105MHR Fimbrial protein HV012_RS20655 ENOG4106PH7 chaperone HV012_RS20685 ENOG4108NAE Fimbrial chaperone protein HV012_RS20695 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV012_RS20720 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV012_RS20725 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HV012_RS20730 ENOG4105C6Z Gluconate HV012_RS20735 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV012_RS20740 ENOG4105DIQ Transcriptional regulator HV012_RS20745 ENOG4105C2I pirin domain protein HV012_RS20750 ENOG4105D9R oxidoreductase HV012_RS20755 ENOG4105WCN acetyltransferase HV012_RS20760 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV012_RS20765 ENOG4105WC8 Conserved Protein HV012_RS20770 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HV012_RS20785 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HV012_RS20790 ENOG4105BZ7 extracellular solute-binding protein family 1 HV012_RS20800 ENOG4108IV0 ABC, transporter HV012_RS20805 ENOG4105C0Z ABC transporter HV012_RS20810 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV012_RS20815 ENOG4105C32 Amino acid ABC transporter (Permease) HV012_RS20820 ENOG4105CP9 extracellular ligand-binding receptor HV012_RS20825 ENOG4105U59 -acetyltransferase HV012_RS20830 ENOG4105CP9 extracellular ligand-binding receptor HV012_RS20835 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV012_RS20840 ENOG4105CRP Part of the ABC transporter FtsEX involved in HV012_RS20845 ENOG4105CAK Cell division ATP-binding protein ftsE HV012_RS20850 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HV012_RS20855 ENOG4106H78 methyltransferase HV012_RS20860 ENOG4105MG3 Membrane HV012_RS20870 ENOG4107FS9 Membrane HV012_RS20885 ENOG4105EX9 Membrane HV012_RS20890 ENOG4108W1V Lipoprotein HV012_RS20895 ENOG4105F9N Major Facilitator Superfamily HV012_RS20900 ENOG4105DSF transport protein HV012_RS20920 ENOG4105E9Q Acyl-transferase HV012_RS20950 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HV012_RS20975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV012_RS20985 ENOG4105C2D reductase HV012_RS20990 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV012_RS20995 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HV012_RS21005 ENOG4105CMI transporter HV012_RS21010 ENOG4105CJ1 ABC, transporter HV012_RS21015 ENOG4105D0S secretion protein (HlyD HV012_RS21020 ENOG4107UNS conserved inner membrane protein HV012_RS21030 ENOG4105GR3 Histidine kinase HV012_RS21035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV012_RS21040 ENOG4108PG2 copper resistance HV012_RS21045 ENOG4105JDN Copper resistance protein HV012_RS21050 ENOG4105VR0 copper resistance HV012_RS21055 ENOG4105E3B Multicopper oxidase HV012_RS21065 ENOG4105DR5 peptidase HV012_RS21095 ENOG410624V efflux system protein HV012_RS21175 ENOG4105CBX hi0933 family HV012_RS21180 ENOG4105CJ3 phosphate transporter HV012_RS21195 ENOG4105DUX Transporter HV012_RS21210 ENOG4105F38 ABC transporter, permease HV012_RS21225 ENOG4105E2R ROK family HV012_RS21235 ENOG4105DGW oligopeptidase A HV012_RS21240 ENOG4105D6S protein involved in catabolism of external DNA HV012_RS21245 ENOG4105DC8 reductase HV012_RS21260 ENOG4105KBH arsR family transcriptional regulator HV012_RS21265 ENOG4107R5R arsenical pump membrane protein HV012_RS21270 ENOG4105K89 arsenate reductase HV012_RS21290 ENOG4106S2D Transcriptional regulator HV012_RS21300 ENOG4107H3J ribonuclease HV012_RS21305 ENOG4105CSH Transporter HV012_RS21310 ENOG41066T0 asmA family HV012_RS21315 ENOG4105CMB EAL domain-containing protein HV012_RS21320 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HV012_RS21335 ENOG4105CS0 peptidase HV012_RS21345 ENOG4105BZU Histidine kinase HV012_RS21350 ENOG4105EJG cellulose synthase HV012_RS21355 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HV012_RS21360 ENOG4107EEX Cellulose synthase regulator protein HV012_RS21365 ENOG4107QZ7 Cellulose synthase catalytic subunit HV012_RS21375 ENOG410661M cytoplasmic protein HV012_RS21380 ENOG4105U74 cellulose biosynthesis protein BcsE HV012_RS21385 ENOG4105WQA Cellulose biosynthesis protein BcsF HV012_RS21390 ENOG4105D1V cellulose synthase operon protein YhjU HV012_RS21410 ENOG4105C28 cystathionine HV012_RS21415 ENOG4105C44 Serine transporter HV012_RS21425 ENOG4108JQ7 (ABC) transporter HV012_RS21430 ENOG4105C3U ABC transporter HV012_RS21435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV012_RS21440 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV012_RS21445 ENOG4105DEF Extracellular solute-binding protein, family 5 HV012_RS21455 ENOG4105DIJ Phosphoethanolamine transferase HV012_RS21460 ENOG4105FCD Major Facilitator HV012_RS21465 ENOG4105EAX Putative lipase HV012_RS21470 ENOG4108R3E Dna-3-methyladenine glycosylase i HV012_RS21475 ENOG4105HNP -acetyltransferase HV012_RS21480 ENOG4107QY8 reductase HV012_RS21485 ENOG4108ZG0 Ompa motb domain protein HV012_RS21490 ENOG4108M60 Transcriptional regulator HV012_RS21500 ENOG4105D7K pfkb domain protein HV012_RS21515 ENOG4106JH6 (LipO)protein HV012_RS21520 ENOG4105D2S major facilitator superfamily HV012_RS21525 ENOG4105MVF Transcriptional regulator HV012_RS21535 ENOG41060TC Hok gef cell toxic protein HV012_RS21555 ENOG4105MEV Acyl-transferase HV012_RS21560 ENOG410688U Inner membrane protein yiaB HV012_RS21565 ENOG4105CMG Carbohydrate kinase HV012_RS21575 ENOG4105T16 Transcriptional regulator (AraC family) HV012_RS21580 ENOG4108UR8 BAX protein HV012_RS21585 ENOG4107T9C Alpha amylase catalytic region HV012_RS21590 ENOG4105JKW Valine--pyruvate aminotransferase HV012_RS21595 ENOG4108XIB electron transport protein ysaA HV012_RS21600 ENOG4105J4Q Transcriptional regulator HV012_RS21610 ENOG4108R66 Conserved Protein HV012_RS21615 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HV012_RS21620 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV012_RS21625 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV012_RS21630 ENOG4105CMG Carbohydrate kinase HV012_RS21635 ENOG4105H6Q decarboxylase HV012_RS21640 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HV012_RS21645 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV012_RS21655 ENOG4105CT4 transporter HV012_RS21665 ENOG4105C26 Dehydrogenase HV012_RS21670 ENOG4105C0A alcohol dehydrogenase HV012_RS21675 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV012_RS21685 ENOG4108U78 Glutathione S-transferase HV012_RS21690 ENOG4105EFX secretion protein, HlyD family HV012_RS21695 ENOG4105FP6 Protein of unknown function (DUF3302) HV012_RS21700 ENOG4105CTS PTS system mannitol-specific HV012_RS21710 ENOG4105E61 Mannitol repressor protein HV012_RS21720 ENOG4108YYI Protein of unknown function (DUF2810) HV012_RS21725 ENOG4108WY4 inner membrane lipoprotein HV012_RS21745 ENOG4105DAA L-lactate HV012_RS21750 ENOG41073TP transcriptional regulator HV012_RS21760 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HV012_RS21775 ENOG4105D7W serine acetyltransferase HV012_RS21790 ENOG4105VW4 glutaredoxin 3 HV012_RS21795 ENOG4107YZP Rhodanese domain protein HV012_RS21805 ENOG41063SB peptidase HV012_RS21810 ENOG4105PXI polysaccharide deacetylase HV012_RS21815 ENOG4105K64 Glycosyl transferase, family 2 HV012_RS21820 ENOG4105D4P Coproporphyrinogen iii oxidase HV012_RS21825 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HV012_RS21840 ENOG4105C2M dna polymerase I HV012_RS21845 ENOG4106HNH Acyl-transferase HV012_RS21855 ENOG4108Z33 Thiol disulfide Interchange Protein HV012_RS21860 ENOG4105E27 serine threonine protein kinase HV012_RS21865 ENOG4105PC1 Conserved Protein HV012_RS21870 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HV012_RS21875 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HV012_RS21905 ENOG4108RR8 protoporphyrinogen oxidase HV012_RS21910 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV012_RS21915 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HV012_RS21935 ENOG4108MR7 Arylsulfotransferase HV012_RS21940 ENOG4108EX3 reductase HV012_RS21945 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV012_RS21950 ENOG4105MDZ Transcriptional activator rfaH HV012_RS21960 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HV012_RS21965 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HV012_RS21970 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV012_RS21980 ENOG4105JC1 sterol-binding domain protein HV012_RS21990 ENOG4105CGY Dna recombination protein HV012_RS21995 ENOG4107HP6 Transcriptional regulator HV012_RS22000 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HV012_RS22005 ENOG4108RTU Aldolase HV012_RS22010 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HV012_RS22025 ENOG4108I5U Uridine phosphorylase HV012_RS22030 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HV012_RS22035 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HV012_RS22045 ENOG4107R1Q Membrane protein FdrA HV012_RS22050 ENOG4107REC cytoplasmic protein HV012_RS22055 ENOG4105C5B carbamate kinase HV012_RS22065 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HV012_RS22070 ENOG4105F52 Transcriptional regulator HV012_RS22085 ENOG4105DZ2 Transcriptional regulator HV012_RS22090 ENOG4105EMK carboxylate amino acid amine transporter HV012_RS22095 ENOG4105DQF Hydrolase HV012_RS22100 ENOG4108EUD Lysophospholipase HV012_RS22105 ENOG410829K Lysine exporter protein (Lyse ygga) HV012_RS22110 ENOG4105CCF Lysine exporter protein (Lyse ygga) HV012_RS22115 ENOG4105C9U ATP-dependent DNA helicase RecQ HV012_RS22120 ENOG4105HDD phospholipase HV012_RS22125 ENOG4108VUY thioesterase Superfamily protein HV012_RS22130 ENOG4105FR1 rard protein HV012_RS22135 ENOG4107QUT magnesium and cobalt transport protein CorA HV012_RS22140 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HV012_RS22145 ENOG4105C4R Atp-dependent dna helicase HV012_RS22150 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HV012_RS22160 ENOG4105CT0 Protein of unknown function, DUF484 HV012_RS22170 ENOG4105S7Z (LipO)protein HV012_RS22190 ENOG4107T0K Adenylate cyclase HV012_RS22200 ENOG41076E6 Uroporphyrinogen-III Synthase HV012_RS22205 ENOG4105ECF c-methyltransferase HV012_RS22210 ENOG410601J HemY protein HV012_RS22215 ENOG4105ENH Sulfatase HV012_RS22220 ENOG4105C4X radical SAM domain protein HV012_RS22245 ENOG4105C85 amino acid HV012_RS22265 ENOG4105EGZ biosynthesis protein HV012_RS22270 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HV012_RS22275 ENOG4108WJ1 acetyltransferase HV012_RS22280 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HV012_RS22285 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV012_RS22290 ENOG4107QQG Dehydrogenase HV012_RS22295 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV012_RS22300 ENOG4105SFE lipopolysaccharide biosynthesis protein HV012_RS22305 ENOG4105ESV Glycosyl transferase, family 4 HV012_RS22310 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HV012_RS22335 ENOG4105C4R Atp-dependent dna helicase HV012_RS22340 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV012_RS22350 ENOG4105EMY transcriptional regulator HV012_RS22355 ENOG4105C7B Threonine dehydratase HV012_RS22365 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV012_RS22370 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HV012_RS22390 ENOG4105C0P Mg chelatase subunit ChlI HV012_RS22395 ENOG4108WFC UPF0438 protein yifE HV012_RS22435 ENOG4107EJG GntR family transcriptional regulator HV012_RS22440 ENOG4105ETE Transcriptional regulator (LacI family HV012_RS22445 ENOG4108RVA ribokinase HV012_RS22450 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV012_RS22455 ENOG4105CNN ABC, transporter HV012_RS22460 ENOG4105C2J ABC transporter HV012_RS22490 ENOG4108VVK transcriptional Regulator, AsnC HV012_RS22495 ENOG4105QTB Flavodoxin HV012_RS22510 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HV012_RS22565 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV012_RS22570 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HV012_RS22575 ENOG4105C8U phosphate abc transporter HV012_RS22580 ENOG4105E2Z phosphate ABC transporter (Permease HV012_RS22585 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HV012_RS22590 ENOG4108UTW Plays a role in the regulation of phosphate uptake HV012_RS22595 ENOG4105CID antiterminator HV012_RS22600 ENOG4105C5Y PTS System HV012_RS22605 ENOG4105CS2 ec 3.2.1.21 HV012_RS22615 ENOG4105DYC esterase HV012_RS22620 ENOG4107VKM 6-phosphogluconolactonase HV012_RS22625 ENOG4106611 bacteriocin immunity HV012_RS22635 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HV012_RS22640 ENOG4105C7N Xanthine uracil vitamin C permease HV012_RS22650 ENOG4108YYH Nadph-dependent fmn reductase HV012_RS22655 ENOG4105E8Q phosphopantetheinyl transferase HV012_RS22670 ENOG4108P6C Tryptophan transporter of low affinity HV012_RS22705 ENOG4105VG0 50S ribosomal protein l34 HV012_RS22715 ENOG4106JVB Replication Protein HV012_RS22760 ENOG4105CVR type I restriction-modification system HV012_RS22775 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HV012_RS22785 ENOG4105C2M dna polymerase I HV012_RS22805 ENOG4106J5W DNA polymerase III (alpha subunit) HV012_RS22945 ENOG4105UZW Tail fiber assembly protein HV012_RS22990 ENOG4108NYK Tape measure protein HV012_RS23080 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV012_RS23085 ENOG4105FA0 parb-like partition protein HV012_RS23090 ENOG4105FA0 parb-like partition protein HV012_RS23095 ENOG4105CB5 ATP-dependent DNA helicase recG HV012_RS23175 ENOG41061EV selenium-binding protein YdfZ HV012_RS23225 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV012_RS23245 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HV012_RS23270 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HV012_RS23320 ENOG4106RMF ParB family HV012_RS23380 ENOG4108ZMA Outer membrane lipoprotein HV012_RS23385 ENOG41066DY Membrane HV012_RS23430 ENOG4108X9F tail fiber protein HV012_RS23430 ENOG4108X9F tail fiber protein HV012_RS23430 ENOG4108X9F tail fiber protein HV012_RS23440 ENOG4105UZW Tail fiber assembly protein HV012_RS23445 ENOG410685N tail fiber protein HV012_RS23450 ENOG4108C33 Resolvase HV012_RS23500 ENOG4105E3B Multicopper oxidase HV012_RS23525 ENOG4108UUM single-stranded DNA-binding protein HV012_RS23540 ENOG4105D7V transposase HV012_RS23635 ENOG4105KT5 UmuD protein HV012_RS23650 ENOG4105MPK DNA polymerase III subunit theta HV012_RS23750 ENOG4108R1E Serine threonine protein phosphatase 1 HV012_RS23815 ENOG4105CDU Replicative dna helicase HV012_RS23840 ENOG4105DFE Dna adenine methylase HV012_RS23845 ENOG4105DH7 May be involved in recombination (By similarity) HV012_RS23950 ENOG4105C8Q Methyl-accepting chemotaxis