locus-tag class description HVY12_RS00010 ENOG4105VZ1 Replication Protein HVY12_RS00040 ENOG4105ED4 portal protein HVY12_RS00130 ENOG4108X9F tail fiber protein HVY12_RS00135 ENOG4105UZW Tail fiber assembly protein HVY12_RS00170 ENOG4105F5W AtP-binding protein HVY12_RS00175 ENOG4105D70 Integrase catalytic subunit HVY12_RS00195 ENOG4105ZTC transcriptional activator, Ogr delta HVY12_RS00200 ENOG4105CFP Peptidase U32 HVY12_RS00205 ENOG4105KWI UPF0339 protein HVY12_RS00210 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY12_RS00215 ENOG4105EB3 Histidine kinase HVY12_RS00245 ENOG4108M24 von Willebrand factor, type A HVY12_RS00250 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVY12_RS00255 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVY12_RS00260 ENOG4105R8A Heat shock protein HVY12_RS00265 ENOG4105D03 DNA-3-methyladenine glycosylase II HVY12_RS00270 ENOG4105BZU Histidine kinase HVY12_RS00285 ENOG4108GAE asmA family HVY12_RS00290 ENOG4105EE5 Membrane protein terC HVY12_RS00295 ENOG4105DAY polysaccharide export protein HVY12_RS00300 ENOG4105KJF protein tyrosine phosphatase HVY12_RS00305 ENOG4105D75 Capsular exopolysaccharide family HVY12_RS00310 ENOG41090RK glycosyl transferase HVY12_RS00315 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVY12_RS00320 ENOG4107RXY Glycosyl transferase HVY12_RS00325 ENOG4108NYJ Colanic acid HVY12_RS00330 ENOG4105ECJ Glycosyl Transferase HVY12_RS00335 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVY12_RS00340 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVY12_RS00345 ENOG4105C30 Nad-dependent epimerase dehydratase HVY12_RS00350 ENOG4105FGF GDP-mannose mannosyl hydrolase HVY12_RS00355 ENOG4106CD9 glycosyl transferase group 1 HVY12_RS00360 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVY12_RS00365 ENOG4107QKV phosphomannomutase HVY12_RS00370 ENOG4105D3Q Sugar transferase HVY12_RS00375 ENOG4105PSV Polysaccharide Biosynthesis Protein HVY12_RS00380 ENOG4105C74 pyruvyl transferase HVY12_RS00385 ENOG4107T8Q Glycosyl transferase (Group 1 HVY12_RS00390 ENOG4105G1A colanic acid biosynthesis protein HVY12_RS00395 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY12_RS00400 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY12_RS00405 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVY12_RS00410 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY12_RS00415 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVY12_RS00425 ENOG4105H63 Glycosyl transferase, family 2 HVY12_RS00430 ENOG4107T8Q Glycosyl transferase (Group 1 HVY12_RS00445 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVY12_RS00485 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVY12_RS00490 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVY12_RS00500 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVY12_RS00515 ENOG4107SRH Nad-dependent epimerase dehydratase HVY12_RS00520 ENOG4105EQ1 Transcriptional regulator HVY12_RS00530 ENOG4105CUB amino acid HVY12_RS00535 ENOG4105CJB Exodeoxyribonuclease I HVY12_RS00540 ENOG4105DFP Integrase HVY12_RS00555 ENOG41077V0 CPS-53 (KpLE1) prophage HVY12_RS00560 ENOG4108R7K Metal Dependent Phosphohydrolase HVY12_RS00565 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HVY12_RS00570 ENOG4105H40 HVY12_RS00600 ENOG4108S1U HVY12_RS00630 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVY12_RS00640 ENOG4108MXB Protein of unknown function (DUF968) HVY12_RS00690 ENOG4105CAR Terminase, large subunit HVY12_RS00700 ENOG4105EFC phage portal protein HK97 family HVY12_RS00745 ENOG4105TKZ Tail Sheath HVY12_RS00765 ENOG4108NKR DNA circulation protein HVY12_RS00785 ENOG4108T86 baseplate J family protein HVY12_RS00790 ENOG4105Y0G tail protein HVY12_RS00795 ENOG4105Y9F tail fiber protein HVY12_RS00800 ENOG4108US3 tail fiber assembly HVY12_RS00810 ENOG4105CKK Glycosyl transferase, family 2 HVY12_RS00815 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVY12_RS00820 ENOG4105DZ1 carboxypeptidase HVY12_RS00830 ENOG4105DR8 Membrane HVY12_RS00840 ENOG4105KTW ethanolamine utilization protein HVY12_RS00845 ENOG4105M3W utilization protein HVY12_RS00855 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVY12_RS00860 ENOG4105C0A alcohol dehydrogenase HVY12_RS00865 ENOG4108EKI Dehydrogenase HVY12_RS00875 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVY12_RS00885 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVY12_RS00890 ENOG4105KNY Microcompartments protein HVY12_RS00895 ENOG4105KNY Microcompartments protein HVY12_RS00905 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVY12_RS00910 ENOG4108ZFT Dehydratase small subunit HVY12_RS00915 ENOG4105YCI dehydratase medium subunit HVY12_RS00920 ENOG4105DMB glycerol dehydratase HVY12_RS00925 ENOG4105EHR propanediol utilization protein pduB HVY12_RS00930 ENOG4105KNY Microcompartments protein HVY12_RS00935 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY12_RS00940 ENOG4107XVH Transcriptional regulator HVY12_RS00945 ENOG4108P62 biosynthesis protein (CbiG) HVY12_RS00950 ENOG4108YZT Adenosylcobinamide kinase HVY12_RS00965 ENOG4108PXI ErfK YbiS YcfS YnhG HVY12_RS00975 ENOG4106P55 Transcriptional regulator HVY12_RS00980 ENOG4107R11 Transcriptional regulator HVY12_RS00990 ENOG4105UQX Mate efflux family protein HVY12_RS01000 ENOG4105FYV Amp nucleosidase HVY12_RS01005 ENOG4105CSH Transporter HVY12_RS01015 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HVY12_RS01030 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) HVY12_RS01040 ENOG4105FCK Membrane HVY12_RS01045 ENOG4105Y0K Inner membrane protein YedR HVY12_RS01055 ENOG4105DVF Cytosine-specific methyltransferase HVY12_RS01060 ENOG41090BB DNA mismatch endonuclease (vsr) HVY12_RS01065 ENOG4105FDR Membrane HVY12_RS01070 ENOG4105CKW Inner membrane protein yedI HVY12_RS01075 ENOG4105VNZ cytoplasmic protein HVY12_RS01090 ENOG4105YX3 cellular response to acidity HVY12_RS01100 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVY12_RS01105 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVY12_RS01115 ENOG4105CN7 Flagellar biosynthetic protein FliP HVY12_RS01120 ENOG4105K0P flagellar biosynthesis protein HVY12_RS01125 ENOG4105DD5 Flagellar motor switch protein HVY12_RS01130 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY12_RS01135 ENOG4107ZI8 flagellar basal body-associated protein flil HVY12_RS01140 ENOG4105WF4 Flagellar hook-length control protein HVY12_RS01145 ENOG4105GSA Flagellar export protein flij HVY12_RS01150 ENOG4108JIR Flagellum-specific ATP synthase HVY12_RS01155 ENOG41090PJ Flagellar assembly protein HVY12_RS01160 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY12_RS01165 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVY12_RS01175 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVY12_RS01180 ENOG41064WM Uncharacterized protein YcgX HVY12_RS01185 ENOG4108MEK Metal-binding protein YodA HVY12_RS01195 ENOG41066VF YeeE YedE family protein HVY12_RS01200 ENOG4108W9D (LipO)protein HVY12_RS01205 ENOG4105E5K Alpha-amylase HVY12_RS01215 ENOG4105MQ3 flagellar protein FliS HVY12_RS01220 ENOG4105DTS flagellar hook-associated HVY12_RS01225 ENOG4105I03 Flagellin HVY12_RS01230 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY12_RS01235 ENOG4108M9K flagella biosynthesis protein FliZ HVY12_RS01240 ENOG4105EAB amino acid AbC transporter HVY12_RS01245 ENOG4105K6H D-cysteine desulfhydrase HVY12_RS01250 ENOG4105E5Q amino acid AbC transporter HVY12_RS01255 ENOG4105CDA abc transporter atp-binding protein HVY12_RS01260 ENOG4105VJY transcriptional regulator HVY12_RS01265 ENOG4105XVG cytoplasmic protein HVY12_RS01275 ENOG4105WH1 Two component transcriptional regulator luxr family HVY12_RS01305 ENOG4106RHG Yeca family HVY12_RS01310 ENOG4105E0U tyrosine-specific transport protein HVY12_RS01315 ENOG4105VVZ metal-binding protein HVY12_RS01320 ENOG41090A1 ferritin HVY12_RS01325 ENOG4105P23 (LipO)protein HVY12_RS01335 ENOG4105N4N Protein of unknown function (DUF2766) HVY12_RS01340 ENOG4108UEC Ferritin-like protein HVY12_RS01345 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVY12_RS01350 ENOG4105C2J ABC transporter HVY12_RS01355 ENOG4105CNN ABC, transporter HVY12_RS01360 ENOG4108K4C ec 3.1.3.12 HVY12_RS01370 ENOG4108VA4 Universal stress protein HVY12_RS01380 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVY12_RS01385 ENOG4107RD7 Flagellar Motor Protein, MotA HVY12_RS01390 ENOG4105ER2 Ompa motb domain protein HVY12_RS01395 ENOG4105CBS Chea signal transduction histidine kinase HVY12_RS01400 ENOG4108V3W Chemotaxis protein, CheW HVY12_RS01405 ENOG4105C8Q Methyl-accepting chemotaxis HVY12_RS01410 ENOG4105BZU Histidine kinase HVY12_RS01420 ENOG4108VYJ response regulator receiver protein HVY12_RS01425 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HVY12_RS01430 ENOG4105D00 flagellar biosynthetic protein flhB HVY12_RS01435 ENOG4105D7B Flagellar biosynthesis protein flha HVY12_RS01440 ENOG4105W13 flagellar protein HVY12_RS01445 ENOG4105C75 arginyL-tRNA synthetase HVY12_RS01450 ENOG4106ZCM YecM protein HVY12_RS01460 ENOG4105CUW cytochrome C-TYPE protein HVY12_RS01465 ENOG4107QY8 reductase HVY12_RS01480 ENOG4105WJG Glutathione HVY12_RS01485 ENOG41081XQ Conserved Protein HVY12_RS01490 ENOG4105D3W isochorismatase HVY12_RS01500 ENOG4108TIT dATP pyrophosphohydrolase HVY12_RS01505 ENOG4105CDY transcriptional regulatory protein HVY12_RS01515 ENOG4107S01 Repressor protein MetJ HVY12_RS01520 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HVY12_RS01530 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVY12_RS01535 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HVY12_RS01545 ENOG4105ED1 spovr family HVY12_RS01555 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY12_RS01565 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVY12_RS01570 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HVY12_RS01575 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVY12_RS01590 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVY12_RS01595 ENOG4108BSC Methyltransferase HVY12_RS01600 ENOG4105E0A ABC, transporter HVY12_RS01605 ENOG4105EHG Permease protein HVY12_RS01610 ENOG4105S10 periplasmic binding protein HVY12_RS01620 ENOG4105VDH Dihydroxyacetone kinase HVY12_RS01625 ENOG4108UTZ Dihydroxyacetone kinase HVY12_RS01630 ENOG4105CMT Dihydroxyacetone kinase HVY12_RS01635 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVY12_RS01645 ENOG4105C3G gtp-binding protein HVY12_RS01655 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVY12_RS01660 ENOG4105CHH sulfate transporter HVY12_RS01665 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVY12_RS01680 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HVY12_RS01690 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVY12_RS01695 ENOG4108YY7 Invasion gene expression up-regulator SirB HVY12_RS01700 ENOG41063JG Transcriptional regulator HVY12_RS01715 ENOG4105EWV Sodium calcium exchanger membrane region HVY12_RS01720 ENOG4105WS7 Cation transport regulator HVY12_RS01725 ENOG4108NH8 Cation transport protein HVY12_RS01730 ENOG41090EX DsrE family HVY12_RS01735 ENOG4105ID0 Putative invasin HVY12_RS01740 ENOG4105WH1 Two component transcriptional regulator luxr family HVY12_RS01745 ENOG4105BZU Histidine kinase HVY12_RS01750 ENOG4105DQQ Major facilitator superfamily MFS_1 HVY12_RS01755 ENOG4105CRU nitrate reductase, alpha subunit HVY12_RS01760 ENOG4108IUE nitrate reductase beta subunit HVY12_RS01765 ENOG4105R3A Nitrate reductase HVY12_RS01770 ENOG41076YT nitrate reductase, gamma subunit HVY12_RS01775 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVY12_RS01780 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY12_RS01820 ENOG4105CIY formyltetrahydrofolate deformylase HVY12_RS01825 ENOG4105K5B UPF0225 protein HVY12_RS01830 ENOG4105D78 K07001 NTE family protein HVY12_RS01835 ENOG4105I93 response regulator HVY12_RS01840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY12_RS01845 ENOG4108SAU DNA-binding protein H-ns HVY12_RS01850 ENOG4107104 thymidine kinase HVY12_RS01855 ENOG4105C0A alcohol dehydrogenase HVY12_RS01860 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVY12_RS01865 ENOG4108J59 Extracellular solute-binding protein, family 5 HVY12_RS01870 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY12_RS01875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY12_RS01880 ENOG4105C3U ABC transporter HVY12_RS01885 ENOG4108JQ7 (ABC) transporter HVY12_RS01905 ENOG4107SVH Potassium channel protein HVY12_RS01910 ENOG4105K9H YciI-like protein HVY12_RS01915 ENOG410822N TonB family HVY12_RS01920 ENOG4105NAU thioesterase Superfamily protein HVY12_RS01935 ENOG4105EIF outer membrane protein W HVY12_RS01950 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVY12_RS01955 ENOG4108EFP Anthranilate synthase component II HVY12_RS01960 ENOG4105CRQ synthase (Component I) HVY12_RS01970 ENOG4105DB7 PHP domain protein HVY12_RS01975 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVY12_RS01980 ENOG4105EG3 transmembrane signal peptide protein HVY12_RS01985 ENOG4105FE9 pseudouridine synthase HVY12_RS02000 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVY12_RS02005 ENOG4105UBK short-chain dehydrogenase reductase HVY12_RS02010 ENOG4105ERU peptidase HVY12_RS02015 ENOG4105RKX Protein of unknown function (DUF2498) HVY12_RS02020 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY12_RS02025 ENOG4107R11 Transcriptional regulator HVY12_RS02045 ENOG4105EKQ RNA-directed DNA polymerase HVY12_RS02050 ENOG4107QM5 aconitate hydratase HVY12_RS02060 ENOG4105EYK Phosphatidylglycerophosphatase B HVY12_RS02065 ENOG4105Q4A inner membrane protein yciS HVY12_RS02070 ENOG4105CFV Tetratricopeptide repeat protein HVY12_RS02080 ENOG4108ZJT translation initiation factor, Sui1 HVY12_RS02090 ENOG4105N2W Transcriptional regulator HVY12_RS02095 ENOG410643D UPF0509 protein HVY12_RS02100 ENOG4105BZU Histidine kinase HVY12_RS02115 ENOG4105Q4T oxidoreductase HVY12_RS02120 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVY12_RS02125 ENOG41067SE Tetr family transcriptional regulator HVY12_RS02130 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY12_RS02135 ENOG4105BZS acriflavin resistance protein HVY12_RS02140 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVY12_RS02145 ENOG4105C2C drug resistance transporter, Bcr CflA HVY12_RS02150 ENOG4108JQ2 peptide transport system atp-binding protein HVY12_RS02155 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVY12_RS02160 ENOG4108EU3 peptide transport system, permease HVY12_RS02165 ENOG4108I5W peptide transport system, permease protein HVY12_RS02170 ENOG4108HIY periplasmic HVY12_RS02175 ENOG4105N0E Protein of unknown function (DUF2543) HVY12_RS02180 ENOG4105E51 psp operon transcriptional activator HVY12_RS02185 ENOG41087YS Phage shock protein A HVY12_RS02190 ENOG4105YYT phage shock protein B HVY12_RS02195 ENOG4105FM1 phage shock protein C HVY12_RS02200 ENOG4105NNG Peripheral inner membrane phage-shock protein HVY12_RS02205 ENOG4105K8Z Phage shock protein HVY12_RS02210 ENOG4105CM6 amino acid regulated cytosolic protein HVY12_RS02220 ENOG4108JU8 Transcriptional regulator HVY12_RS02225 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVY12_RS02230 ENOG4107S8C mandelate racemase muconate lactonizing HVY12_RS02235 ENOG4105KXI murein peptide amidase A HVY12_RS02240 ENOG4107QSI ABC, transporter HVY12_RS02255 ENOG4105D64 Mechanosensitive ion channel HVY12_RS02260 ENOG4105S5I Membrane HVY12_RS02265 ENOG4105Q9Y Universal stress protein HVY12_RS02270 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVY12_RS02275 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY12_RS02280 ENOG4108DG9 Smr protein MutS2 HVY12_RS02285 ENOG4105BZU Histidine kinase HVY12_RS02295 ENOG4105C1J atp-dependent rna helicase HVY12_RS02305 ENOG4108RW8 Universal stress protein F HVY12_RS02310 ENOG4105FCK Membrane HVY12_RS02315 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVY12_RS02320 ENOG4105IKK cytoplasmic protein HVY12_RS02325 ENOG41090X5 Heat shock protein hslJ HVY12_RS02330 ENOG4105C5I Dehydrogenase HVY12_RS02335 ENOG4107H52 Dicarboxylate transport HVY12_RS02340 ENOG410689M (LipO)protein HVY12_RS02345 ENOG4105WXT Conserved Protein HVY12_RS02350 ENOG4107S5I aldo keto reductase HVY12_RS02360 ENOG4105CQ7 ATP-dependent helicase HVY12_RS02365 ENOG4107DB1 DUF218 domain HVY12_RS02370 ENOG4105C26 Dehydrogenase HVY12_RS02375 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVY12_RS02380 ENOG4105CPW cytochrome b561 HVY12_RS02385 ENOG4105UPP uncharacterized protein ydcA HVY12_RS02390 ENOG4107NK6 Hok/gef family HVY12_RS02395 ENOG4105C8Q Methyl-accepting chemotaxis HVY12_RS02400 ENOG4105DDW LysR family Transcriptional regulator HVY12_RS02405 ENOG4105E32 cytoplasmic protein HVY12_RS02415 ENOG4105Z2P Protein of unknown function (DUF465) HVY12_RS02420 ENOG4108Z9I -acetyltransferase HVY12_RS02425 ENOG4107WE3 acetyltransferase YdcK HVY12_RS02430 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HVY12_RS02435 ENOG41088CC tellurite resistance protein tehB HVY12_RS02440 ENOG4108KKZ (LipO)protein HVY12_RS02445 ENOG4105DKK Benzoate HVY12_RS02450 ENOG4108JCI Transcriptional regulator HVY12_RS02455 ENOG4105CFP Peptidase U32 HVY12_RS02460 ENOG4105RR0 Protein of unknown function (DUF2554) HVY12_RS02470 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HVY12_RS02475 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY12_RS02480 ENOG4107TYH extracellular solute-binding protein family 1 HVY12_RS02485 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY12_RS02490 ENOG4105D81 ABC transporter, permease HVY12_RS02495 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVY12_RS02510 ENOG410654E Membrane HVY12_RS02515 ENOG4105R71 cytoplasmic protein HVY12_RS02520 ENOG4108T9Y Inner membrane protein ydcZ HVY12_RS02525 ENOG4108Z7F N-acetyltransferase HVY12_RS02530 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVY12_RS02535 ENOG4105CHB tonB-dependent Receptor HVY12_RS02540 ENOG4108NS2 receptor HVY12_RS02545 ENOG4105C85 amino acid HVY12_RS02565 ENOG4105D70 Integrase catalytic subunit HVY12_RS02570 ENOG4105F5W AtP-binding protein HVY12_RS02605 ENOG4105EUZ Beta-lactamase domain protein HVY12_RS02615 ENOG4108MEJ flavin reductase domain protein HVY12_RS02620 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVY12_RS02625 ENOG4105JAB phenazine biosynthesis protein, phzf family HVY12_RS02630 ENOG4105D0D Nitrate reductase 2, gamma subunit HVY12_RS02635 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HVY12_RS02640 ENOG4108IUE nitrate reductase beta subunit HVY12_RS02645 ENOG4105CRU nitrate reductase, alpha subunit HVY12_RS02650 ENOG4107QND Nitrite extrusion protein HVY12_RS02655 ENOG4105RPH Inner membrane protein YddG HVY12_RS02665 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY12_RS02670 ENOG4108MG3 formate dehydrogenase HVY12_RS02675 ENOG41084S7 Plasmid maintenance system antidote protein HVY12_RS02685 ENOG4105DQ4 alcohol dehydrogenase HVY12_RS02695 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVY12_RS02700 ENOG4105TPS biofilm-dependent modulation protein HVY12_RS02705 ENOG4108Z9K Osmotically inducible protein HVY12_RS02715 ENOG4105BZU Histidine kinase HVY12_RS02725 ENOG4105F32 YngK protein HVY12_RS02730 ENOG4105E5D amino acid HVY12_RS02735 ENOG4105CVK Glutamate decarboxylase HVY12_RS02740 ENOG4107RAN Peptidase, M16 HVY12_RS02745 ENOG4105PE1 Receptor HVY12_RS02750 ENOG4105CQ0 ABC transporter HVY12_RS02755 ENOG4105C4X radical SAM domain protein HVY12_RS02760 ENOG4105ENH Sulfatase HVY12_RS02765 ENOG4105TNG K13735 adhesin invasin HVY12_RS02775 ENOG4105CAF HipA N-terminal domain protein HVY12_RS02780 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HVY12_RS02795 ENOG4105FFC UPF0187 protein HVY12_RS02805 ENOG4105BZU Histidine kinase HVY12_RS02810 ENOG4105M0C cytoplasmic protein HVY12_RS02815 ENOG4105CSV Glutaminase HVY12_RS02820 ENOG4105C26 Dehydrogenase HVY12_RS02825 ENOG4105EGI Transcriptional regulator HVY12_RS02840 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVY12_RS02845 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVY12_RS02850 ENOG4106DNR multiple antibiotic resistance protein HVY12_RS02855 ENOG4108594 Permease of the drug metabolite transporter HVY12_RS02860 ENOG4105E5W Transporter HVY12_RS02875 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVY12_RS02880 ENOG4105DGW oligopeptidase A HVY12_RS02885 ENOG4105EMU Dehydrogenase HVY12_RS02890 ENOG4107XBN GntR Family Transcriptional Regulator HVY12_RS02895 ENOG41061EV selenium-binding protein YdfZ HVY12_RS02900 ENOG4105DEI Mannitol dehydrogenase HVY12_RS02910 ENOG4105CXK mandelate racemase muconate lactonizing HVY12_RS02925 ENOG4108MK9 spermidine N(1)-acetyltransferase HVY12_RS02935 ENOG4105KBG Protein of unknown function (DUF1161) HVY12_RS02940 ENOG4107QY8 reductase HVY12_RS02945 ENOG4105QAX Iron-sulfur HVY12_RS02950 ENOG4107KGK dmso reductase anchor subunit HVY12_RS02955 ENOG4108NEM leader-binding protein dmsD HVY12_RS02965 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY12_RS02970 ENOG4105DAG ROK family HVY12_RS02975 ENOG4106NZI LysR family Transcriptional regulator HVY12_RS02980 ENOG4105D94 Major Facilitator Superfamily HVY12_RS02995 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVY12_RS03010 ENOG4105DSF transport protein HVY12_RS03015 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY12_RS03020 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY12_RS03025 ENOG4105C5D exported protein HVY12_RS03030 ENOG4105D5Q Arginine ornithine antiporter HVY12_RS03040 ENOG4105RA2 Membrane HVY12_RS03045 ENOG4107EXC regulatoR HVY12_RS03050 ENOG4105JJR Histidine kinase HVY12_RS03060 ENOG4105C9Q fumarate hydratase class II HVY12_RS03065 ENOG4107GFK fumarate HVY12_RS03070 ENOG4105EIP mannose-6-phosphate isomerase HVY12_RS03075 ENOG4106J39 exported protein HVY12_RS03080 ENOG4108QNI outer membrane porin protein HVY12_RS03085 ENOG4105CT4 transporter HVY12_RS03090 ENOG4105CNT hydrolase family 2 HVY12_RS03095 ENOG4105XEA Tetr family transcriptional regulator HVY12_RS03100 ENOG4107ZQV short-chain dehydrogenase reductase HVY12_RS03105 ENOG4107P2S Transcriptional regulator HVY12_RS03110 ENOG4105CI1 PTS System HVY12_RS03115 ENOG4105C87 Aminotransferase class I and II HVY12_RS03125 ENOG4105D9R oxidoreductase HVY12_RS03130 ENOG4106C6R beta-lactam resistance protein HVY12_RS03135 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVY12_RS03140 ENOG4105M9B inner membrane protein ydgK HVY12_RS03165 ENOG4108UQQ Electron transport complex HVY12_RS03175 ENOG4105CSM endonuclease III HVY12_RS03180 ENOG4105DUX Transporter HVY12_RS03185 ENOG4108K3A Glutathione S-transferase HVY12_RS03190 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVY12_RS03205 ENOG410642K Lysozyme inhibitor HVY12_RS03215 ENOG4108XTF Outer Membrane Lipoprotein HVY12_RS03230 ENOG4105Y49 secretion protein, HlyD family HVY12_RS03235 ENOG4105DSW Fusaric acid resistance protein HVY12_RS03240 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY12_RS03245 ENOG4107RGM aldo keto reductase HVY12_RS03250 ENOG4105XZD Fe-S protein HVY12_RS03255 ENOG4108WUH Transcriptional regulator, TetR family HVY12_RS03260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY12_RS03265 ENOG4108UYE Lactoylglutathione lyase HVY12_RS03285 ENOG4105M2J Glutaredoxin HVY12_RS03290 ENOG4105K4H Nlp p60 protein HVY12_RS03295 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY12_RS03300 ENOG4105F27 Major Facilitator HVY12_RS03315 ENOG4105F52 Transcriptional regulator HVY12_RS03320 ENOG4105CZQ inner membrane transport protein YdhC HVY12_RS03325 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVY12_RS03330 ENOG4108R6K riboflavin synthase, subunit alpha HVY12_RS03355 ENOG4105N0V mono-oxygenase ydhR HVY12_RS03360 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVY12_RS03365 ENOG4108Y7C Conserved Protein HVY12_RS03370 ENOG4105RFR Protein of unknown function (DUF2767) HVY12_RS03375 ENOG4105CA9 Pyruvate kinase HVY12_RS03380 ENOG4105KMX major outer membrane lipoprotein HVY12_RS03385 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY12_RS03400 ENOG4105JRK feS assembly protein SufD HVY12_RS03405 ENOG4105C3K feS assembly ATPase SufC HVY12_RS03410 ENOG4105DIW FeS assembly protein SUFB HVY12_RS03415 ENOG4108Z4V iron-sulfur cluster assembly HVY12_RS03420 ENOG410671Z uncharacterized protein ydiH HVY12_RS03425 ENOG4105KA0 thioesterase Superfamily protein HVY12_RS03430 ENOG4105CQB FAD linked oxidase domain protein HVY12_RS03435 ENOG4105IPI Membrane HVY12_RS03445 ENOG4105SUA Ydil protein HVY12_RS03470 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVY12_RS03480 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY12_RS03495 ENOG4108TC0 Diguanylate phosphodiesterase HVY12_RS03500 ENOG4108QBX (LipO)protein HVY12_RS03510 ENOG4108V06 Glutathione peroxidase HVY12_RS03530 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY12_RS03600 ENOG4105ED4 portal protein HVY12_RS03680 ENOG4108X9F tail fiber protein HVY12_RS03685 ENOG4105UZW Tail fiber assembly protein HVY12_RS03770 ENOG41082NX 50s ribosomal protein l35 HVY12_RS03775 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVY12_RS03790 ENOG4108NE3 Salt-induced outer membrane protein HVY12_RS03795 ENOG4105DE4 1-phosphofructokinase HVY12_RS03800 ENOG4105P10 Uncharacterized protein ydiZ HVY12_RS03810 ENOG4107PN8 YfeABCD locus regulator HVY12_RS03815 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVY12_RS03820 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVY12_RS03825 ENOG4108ETY sodium dicarboxylate symporter HVY12_RS03835 ENOG4105CH6 catalase HVY12_RS03840 ENOG410901P UPF0249 protein HVY12_RS03845 ENOG4105F8D glycoside hydrolase family 4 HVY12_RS03850 ENOG4105EZV Transcriptional regulator HVY12_RS03855 ENOG4105VCP PTS System HVY12_RS03860 ENOG4105CK1 PTS System HVY12_RS03865 ENOG4105VZJ PTS System HVY12_RS03870 ENOG4105KKI DNA-binding transcriptional activator OsmE HVY12_RS03875 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HVY12_RS03885 ENOG4108SPG Periplasmic Protein HVY12_RS03890 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HVY12_RS03915 ENOG4105CGK Exodeoxyribonuclease III HVY12_RS03920 ENOG4108RSN SNARE associated Golgi HVY12_RS03925 ENOG4108KCW iron-sulfur cluster binding HVY12_RS03930 ENOG4108N5C SNARE associated Golgi protein-related protein HVY12_RS03935 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY12_RS03940 ENOG4105VNH ABC transporter solute-binding protein HVY12_RS03945 ENOG4105CXZ ABC transporter, permease HVY12_RS03950 ENOG4108VGW abc transporter atp-binding protein HVY12_RS03955 ENOG4107RM6 sulfurtransferase HVY12_RS03960 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVY12_RS03965 ENOG4105M6F mutator MutT protein HVY12_RS03970 ENOG4105MTM Protein of unknown function (DUF1496) HVY12_RS03975 ENOG4105D82 Glutamate dehydrogenase HVY12_RS03980 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY12_RS03990 ENOG41069NU Nitroreductase HVY12_RS03995 ENOG4105D07 Signal peptide peptidase, SppA HVY12_RS04005 ENOG4105HDK L-asparaginase HVY12_RS04015 ENOG4108RWI nicotinamidase HVY12_RS04020 ENOG4105VUT cytoplasmic protein HVY12_RS04030 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVY12_RS04035 ENOG4105DSB aldose 1-epimerase HVY12_RS04040 ENOG4105CV8 reductase HVY12_RS04045 ENOG4105GNX MltA-interacting MipA family protein HVY12_RS04050 ENOG4105CYN Serine protein kinase HVY12_RS04060 ENOG4106KTS Inner membrane protein yeaI HVY12_RS04065 ENOG4108KHP Diguanylate cyclase HVY12_RS04070 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVY12_RS04085 ENOG4105K78 MarR family Transcriptional regulator HVY12_RS04090 ENOG4105UCG Domain of unknown function (DUF333) HVY12_RS04095 ENOG410620I Diguanylate cyclase HVY12_RS04100 ENOG4106G4W HVY12_RS04110 ENOG4105Y3U Transglycosylase-associated protein HVY12_RS04115 ENOG4105YP6 Domain of unknown function (DUF1869) HVY12_RS04120 ENOG4108YS1 cytoplasmic protein HVY12_RS04130 ENOG4105EJC lysr family transcriptional regulator HVY12_RS04140 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVY12_RS04145 ENOG4105CEY Amp-dependent synthetase and ligase HVY12_RS04150 ENOG4105Y4Z Outer Membrane Lipoprotein HVY12_RS04155 ENOG41072GX Peptidase M22 Glycoprotease HVY12_RS04160 ENOG4105DVT helicase HVY12_RS04165 ENOG4105M4H endoribonuclease L-psp HVY12_RS04170 ENOG4105V2F Uncharacterized protein yoac HVY12_RS04185 ENOG4105CRQ synthase (Component I) HVY12_RS04195 ENOG4105EJQ L-serine dehydratase HVY12_RS04200 ENOG4107XTP (EAL) domain protein HVY12_RS04205 ENOG4105EE5 Membrane protein terC HVY12_RS04210 ENOG4105DAS pts system HVY12_RS04215 ENOG4105ETZ PTS System HVY12_RS04220 ENOG4105F3R pts system mannose fructose sorbose family iid HVY12_RS04235 ENOG4105DHI Methyltransferase HVY12_RS04250 ENOG4105Q3Y exported protein HVY12_RS04260 ENOG4105TIK HVY12_RS04265 ENOG4105J4Q Transcriptional regulator HVY12_RS04270 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY12_RS04280 ENOG4105CN1 protease HVY12_RS04285 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HVY12_RS04290 ENOG4108ZGC gaf domain protein HVY12_RS04295 ENOG4105H2K paraquat-inducible protein a HVY12_RS04300 ENOG4105DY2 Paraquat-inducible protein b HVY12_RS04310 ENOG4105WT8 Protein of unknown function (DUF1480) HVY12_RS04315 ENOG4105UVW uncharacterized protein yebW HVY12_RS04320 ENOG4108R1E Serine threonine protein phosphatase 1 HVY12_RS04325 ENOG4105NKT exported protein HVY12_RS04330 ENOG4108PNC copper resistance HVY12_RS04335 ENOG4105FXM Copper resistance protein HVY12_RS04340 ENOG4105MPK DNA polymerase III subunit theta HVY12_RS04345 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY12_RS04350 ENOG4105UMD exodeoxyribonuclease X HVY12_RS04360 ENOG4105F5W AtP-binding protein HVY12_RS04365 ENOG4105D70 Integrase catalytic subunit HVY12_RS04375 ENOG4108Q2J Inner membrane protein YebE HVY12_RS04385 ENOG4105X2V dna damage-inducible protein HVY12_RS04395 ENOG4108UHU Aldolase HVY12_RS04400 ENOG4105C01 Dihydroxy-acid dehydratase HVY12_RS04405 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVY12_RS04415 ENOG4106KNT transcriptional regulator HVY12_RS04420 ENOG4105CA9 Pyruvate kinase HVY12_RS04425 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVY12_RS04430 ENOG4105DR5 peptidase HVY12_RS04435 ENOG4105NXV High-affinity zinc uptake system protein HVY12_RS04445 ENOG4105FAV ABC, transporter HVY12_RS04450 ENOG4108ZZ3 UPF0260 protein HVY12_RS04455 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVY12_RS04470 ENOG4107QMS site-determining protein HVY12_RS04485 ENOG410658X HVY12_RS04495 ENOG4105BZU Histidine kinase HVY12_RS04500 ENOG4105PI0 Ferredoxin HVY12_RS04505 ENOG4105CDY transcriptional regulatory protein HVY12_RS04520 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY12_RS04530 ENOG4105VEQ Cold shock protein HVY12_RS04545 ENOG410814C multidrug resistance protein HVY12_RS04570 ENOG4108HMX isocitrate dehydrogenase (NADP) HVY12_RS04575 ENOG4108R99 pseudouridine synthase HVY12_RS04595 ENOG4107QTF adenylosuccinate lyase HVY12_RS04600 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY12_RS04605 ENOG4105IFJ Histidine kinase HVY12_RS04610 ENOG4105EZE Cupin 4 family protein HVY12_RS04620 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY12_RS04630 ENOG4105D38 putrescine abc transporter HVY12_RS04635 ENOG4107RUE extracellular solute-binding protein family 1 HVY12_RS04650 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVY12_RS04660 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY12_RS04665 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVY12_RS04670 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY12_RS04675 ENOG4105IQC Inner membrane protein YcfT HVY12_RS04680 ENOG4108JA2 transcriptioN-repair coupling factor HVY12_RS04685 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY12_RS04690 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVY12_RS04695 ENOG4108IND Tetr family transcriptional regulator HVY12_RS04700 ENOG4107MBR 17 kDa surface antigen HVY12_RS04705 ENOG4105CEP NADH dehydrogenase HVY12_RS04720 ENOG4108RUM thiamine kinase HVY12_RS04725 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVY12_RS04730 ENOG41090DQ Lipoprotein HVY12_RS04735 ENOG4105K59 histidine triad (HIT) protein HVY12_RS04745 ENOG4105CI1 PTS System HVY12_RS04750 ENOG4105F8V Hydrolase, tatD family HVY12_RS04755 ENOG4107QRG dna polymerase iii HVY12_RS04765 ENOG4105HHA aminodeoxychorismate lyase HVY12_RS04770 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVY12_RS04775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY12_RS04780 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVY12_RS04785 ENOG4105CHR reductase HVY12_RS04790 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVY12_RS04810 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVY12_RS04815 ENOG4108UHJ MAF-like protein HVY12_RS04820 ENOG4105EI2 Pseudouridine synthase HVY12_RS04825 ENOG4107QQB Ribonuclease E HVY12_RS04830 ENOG4105DTJ flagellar hook-associated protein HVY12_RS04835 ENOG4105E1Q flagellar hook-associated protein HVY12_RS04840 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVY12_RS04855 ENOG4105CGA flagellar basal-body rod protein FlgG HVY12_RS04860 ENOG4108KPB Flagellar basal-body rod protein FlgF HVY12_RS04865 ENOG4105BZE flagellar hook protein, FlgE HVY12_RS04870 ENOG4105W00 Flagellar hook capping protein HVY12_RS04875 ENOG4108ZC9 flagellar basal-body rod protein flgc HVY12_RS04880 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVY12_RS04885 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVY12_RS04890 ENOG4105M9M anti-sigma28 factor FlgM HVY12_RS04895 ENOG4105QVD Flagella synthesis protein FlgN HVY12_RS04900 ENOG4105CJR Integral membrane protein (MviN HVY12_RS04905 ENOG4105EP9 oxidoreductase HVY12_RS04915 ENOG4105D9U N-acetyltransferase HVY12_RS04925 ENOG4105F3T (LipO)protein HVY12_RS04935 ENOG4105MEA DNA damage-inducible protein i HVY12_RS04940 ENOG4105PVA Biofilm formation regulatory protein BssS HVY12_RS04950 ENOG4106974 biofilm formation HVY12_RS04955 ENOG4105DS1 cytochrome b561 HVY12_RS04960 ENOG4108YYC ycei family HVY12_RS04970 ENOG4105D1S lipid A biosynthesis HVY12_RS04975 ENOG4105C6X Major Facilitator HVY12_RS04980 ENOG4108W47 Acidic protein msyB HVY12_RS04985 ENOG4105NAC (LipO)protein HVY12_RS04990 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVY12_RS05005 ENOG4107RZC phospholipase d HVY12_RS05010 ENOG4108UVJ appr-1-p processing domain protein HVY12_RS05025 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVY12_RS05030 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVY12_RS05035 ENOG41086KC Transcriptional regulator HVY12_RS05040 ENOG4108XDW curli assembly protein CsgE HVY12_RS05045 ENOG4108WYR Curli production assembly transport component, CsgF HVY12_RS05050 ENOG4105P8Q Curli production assembly transport component CsgG HVY12_RS05055 ENOG4108UQ5 membrane protein YcdZ HVY12_RS05060 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVY12_RS05070 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HVY12_RS05080 ENOG4105D5M phosphate starvation-inducible protein HVY12_RS05085 ENOG4105DBE peroxidase HVY12_RS05090 ENOG410650H (LipO)protein HVY12_RS05095 ENOG4105EKT )-iron permease HVY12_RS05100 ENOG4105CK7 Sodium proline symporter HVY12_RS05105 ENOG4105C26 Dehydrogenase HVY12_RS05110 ENOG4108R86 Transcriptional regulator HVY12_RS05115 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVY12_RS05125 ENOG4105XH3 HVY12_RS05130 ENOG4105D6F Phosphatase HVY12_RS05140 ENOG4105RQF LysR family Transcriptional regulator HVY12_RS05145 ENOG4105MWK D-amino acid dehydrogenase, small subunit HVY12_RS05170 ENOG4108J2R molybdopterin oxidoreductase HVY12_RS05175 ENOG4105CUW cytochrome C-TYPE protein HVY12_RS05180 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVY12_RS05185 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVY12_RS05190 ENOG4105BZU Histidine kinase HVY12_RS05195 ENOG4105HEE Binding Domain protein HVY12_RS05200 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVY12_RS05220 ENOG4105VEQ Cold shock protein HVY12_RS05225 ENOG41060EU Cold shock-like protein HVY12_RS05230 ENOG4105D6F Phosphatase HVY12_RS05240 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY12_RS05245 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY12_RS05250 ENOG4105MVP hydrogenase-1 operon protein HyaF HVY12_RS05255 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVY12_RS05260 ENOG4108USZ hydrogenase HVY12_RS05265 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVY12_RS05270 ENOG4105DPX Hydrogenase, large subunit HVY12_RS05275 ENOG4105E3S small subunit HVY12_RS05290 ENOG4108X9F tail fiber protein HVY12_RS05295 ENOG4105H38 Membrane HVY12_RS05365 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HVY12_RS05460 ENOG4105HRS Antitermination protein HVY12_RS05465 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVY12_RS05470 ENOG4108MXB Protein of unknown function (DUF968) HVY12_RS05480 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVY12_RS05530 ENOG4105JBR DNA replication protein HVY12_RS05585 ENOG4106G8A Qin prophage HVY12_RS05595 ENOG4105F5W AtP-binding protein HVY12_RS05600 ENOG4105D70 Integrase catalytic subunit HVY12_RS05605 ENOG41076J9 exonuclease VIII HVY12_RS05620 ENOG4108MN8 Membrane HVY12_RS05625 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVY12_RS05630 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVY12_RS05645 ENOG4105K4P CoA-binding domain protein HVY12_RS05660 ENOG41088T4 Helicase IV HVY12_RS05665 ENOG410901E Membrane HVY12_RS05670 ENOG4105EM2 membrane HVY12_RS05675 ENOG4108RZ1 DNA transformation protein HVY12_RS05685 ENOG4105UYK outer membrane protein a HVY12_RS05695 ENOG4105DAN ATP-dependent protease HVY12_RS05705 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVY12_RS05710 ENOG4108Q2G (LipO)protein HVY12_RS05715 ENOG4105DY2 Paraquat-inducible protein b HVY12_RS05720 ENOG4105F1S paraquat-inducible protein a HVY12_RS05725 ENOG4105C5H ABC transporter HVY12_RS05735 ENOG4105QVC MOSC domain-containing protein HVY12_RS05740 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVY12_RS05750 ENOG4108UZX fmn reductase HVY12_RS05755 ENOG4105GVF (ABC) transporter HVY12_RS05765 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVY12_RS05775 ENOG4105CD8 aminopeptidase N HVY12_RS05780 ENOG4107RH7 Nicotinate phosphoribosyltransferase HVY12_RS05790 ENOG4105FCK Membrane HVY12_RS05795 ENOG4105CGF Aromatic amino acid aminotransferase HVY12_RS05800 ENOG4105C5X domain protein HVY12_RS05805 ENOG4105EAQ (twin-arginine translocation) pathway signal HVY12_RS05810 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVY12_RS05815 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HVY12_RS05820 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVY12_RS05830 ENOG4106371 Methyltransferase HVY12_RS05835 ENOG4107S90 membrAne HVY12_RS05840 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVY12_RS05855 ENOG4105T0Z Conserved Protein HVY12_RS05865 ENOG4105BZ1 (ABC) transporter HVY12_RS05870 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVY12_RS05880 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVY12_RS05890 ENOG4108K0D peptidase, M48 HVY12_RS05905 ENOG4107VMU Membrane HVY12_RS05910 ENOG4105DDY UPF0142 protein ycaO HVY12_RS05915 ENOG4105TMB Formate nitrite transporter HVY12_RS05920 ENOG4105C6N Formate acetyltransferase HVY12_RS05925 ENOG4105F1A Pyruvate formate-lyase HVY12_RS05930 ENOG4105EJG cellulose synthase HVY12_RS05935 ENOG4107EEX Cellulose synthase regulator protein HVY12_RS05940 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY12_RS05945 ENOG41064RH membrane protein YliF HVY12_RS05950 ENOG4105BZU Histidine kinase HVY12_RS05960 ENOG4105CHJ isochorismatase hydrolase HVY12_RS05965 ENOG4107KGK dmso reductase anchor subunit HVY12_RS05970 ENOG4105QAX Iron-sulfur HVY12_RS05975 ENOG4107QY8 reductase HVY12_RS05980 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY12_RS06105 ENOG4105D70 Integrase catalytic subunit HVY12_RS06110 ENOG4105F5W AtP-binding protein HVY12_RS06250 ENOG4105D1H recombination factor protein RarA HVY12_RS06260 ENOG4105CNU cell division protein FtsK HVY12_RS06270 ENOG4105C3M thioredoxin reductase HVY12_RS06275 ENOG4108JJ9 ABC, transporter HVY12_RS06280 ENOG4108JJ8 (ABC) transporter HVY12_RS06290 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVY12_RS06305 ENOG4105CW0 outer membrane usher protein HVY12_RS06310 ENOG4108MQF Chaperone HVY12_RS06315 ENOG41063W2 Fimbrial protein HVY12_RS06325 ENOG4105M6W Crispr-associated protein, Csy3 family HVY12_RS06330 ENOG4105DZX CRISPR-associated protein, Csy2 family HVY12_RS06335 ENOG4105ENG CRISPR-associated protein, Csy1 family HVY12_RS06340 ENOG4107IIZ CRISPR-associated helicase, Cas3 HVY12_RS06345 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVY12_RS06350 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY12_RS06360 ENOG4105VEQ Cold shock protein HVY12_RS06370 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVY12_RS06375 ENOG4108MJ5 VirK protein HVY12_RS06380 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVY12_RS06385 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY12_RS06390 ENOG4105DWU Membrane HVY12_RS06400 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY12_RS06405 ENOG4105C7K acetolactate synthase HVY12_RS06410 ENOG4105C5W Aldolase HVY12_RS06415 ENOG4105CGD Nad-dependent epimerase dehydratase HVY12_RS06420 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY12_RS06425 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY12_RS06435 ENOG41064MM (LipO)protein HVY12_RS06440 ENOG4105E5Z arginine transporter ATP-binding subunit HVY12_RS06445 ENOG4106PMH Extracellular solute-binding protein family 3 HVY12_RS06450 ENOG4105GBT ABC transporter HVY12_RS06455 ENOG4105DMR ABC, transporter HVY12_RS06460 ENOG4106TNF Periplasmic binding protein HVY12_RS06470 ENOG4105RBQ inner membrane protein ybjO HVY12_RS06475 ENOG4105D38 putrescine abc transporter HVY12_RS06480 ENOG4105F38 ABC transporter, permease HVY12_RS06485 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY12_RS06490 ENOG4107RUE extracellular solute-binding protein family 1 HVY12_RS06495 ENOG4108RMJ sensory transduction regulator HVY12_RS06505 ENOG4108DBC nitroreductase HVY12_RS06510 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HVY12_RS06515 ENOG41090BQ Glutaredoxin HVY12_RS06520 ENOG4105GWF inner membrane protein YbjM HVY12_RS06530 ENOG4108RFG Tetr family transcriptional regulator HVY12_RS06535 ENOG4106UW1 Major Facilitator superfamily HVY12_RS06540 ENOG4108HCJ Hydrolase HVY12_RS06550 ENOG4107QF7 multi-drug HVY12_RS06555 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVY12_RS06560 ENOG4107FB0 transcriptional regulator DeoR family HVY12_RS06565 ENOG4105DZ1 carboxypeptidase HVY12_RS06570 ENOG4108TGY Glutathione S-transferase HVY12_RS06575 ENOG4105D8V Glucose sorbosone dehydrogenase HVY12_RS06580 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVY12_RS06585 ENOG4105C4C beta-galactosidase HVY12_RS06590 ENOG4105ETE Transcriptional regulator (LacI family HVY12_RS06595 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVY12_RS06605 ENOG41064RH membrane protein YliF HVY12_RS06610 ENOG4105BZU Histidine kinase HVY12_RS06625 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY12_RS06630 ENOG4108JQ6 ABC transporter HVY12_RS06635 ENOG4105D44 asparaginase HVY12_RS06640 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVY12_RS06645 ENOG4105D06 uba thif-type nad fad binding protein HVY12_RS06650 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY12_RS06655 ENOG4105F1A Pyruvate formate-lyase HVY12_RS06665 ENOG4108HCJ Hydrolase HVY12_RS06670 ENOG41072TH Protein of unknown function (DUF1479) HVY12_RS06675 ENOG4105C5H ABC transporter HVY12_RS06680 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY12_RS06685 ENOG4105F4P )-transporter HVY12_RS06690 ENOG4105KST dependent repressor HVY12_RS06700 ENOG4108I6E Sulfatase HVY12_RS06705 ENOG4108T1M outer membrane protein x HVY12_RS06715 ENOG4107AQZ Membrane HVY12_RS06725 ENOG4107R0W ABC transporter HVY12_RS06730 ENOG4105E5Q amino acid AbC transporter HVY12_RS06735 ENOG4105CDA abc transporter atp-binding protein HVY12_RS06740 ENOG4105D8X mechanosensitive ion channel HVY12_RS06750 ENOG4105ZY9 UPF0379 protein ybiM HVY12_RS06755 ENOG4108IU3 tonb-dependent siderophore receptor HVY12_RS06765 ENOG4105KSC Transcriptional regulator, TraR DksA family HVY12_RS06770 ENOG4105VR4 UPF0379 protein ybiJ HVY12_RS06775 ENOG4105DG4 malate L-lactate dehydrogenase HVY12_RS06780 ENOG4108MTB glycosyl transferase family HVY12_RS06785 ENOG4105DVT helicase HVY12_RS06790 ENOG4108UV1 cellular component movement HVY12_RS06795 ENOG4105C1J atp-dependent rna helicase HVY12_RS06800 ENOG4107MVR Transcriptional regulator HVY12_RS06810 ENOG4105CJ1 ABC, transporter HVY12_RS06815 ENOG4107QWP ABC-2 type transporter HVY12_RS06820 ENOG4107QWP ABC-2 type transporter HVY12_RS06825 ENOG4105I9U inner membrane protein ybhQ HVY12_RS06830 ENOG4105X23 Endonuclease Exonuclease phosphatase HVY12_RS06835 ENOG4105DZQ phospholipase D Transphosphatidylase HVY12_RS06840 ENOG4107UXM Membrane HVY12_RS06850 ENOG4105HFZ Membrane HVY12_RS06855 ENOG4108ZAF Molybdopterin HVY12_RS06860 ENOG4105M00 molybdopterin converting factor, subunit 1 HVY12_RS06870 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY12_RS06880 ENOG4105CHW UPF0052 protein HVY12_RS06890 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY12_RS06895 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVY12_RS06910 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVY12_RS06915 ENOG4108V1U phospholipid-binding protein HVY12_RS06920 ENOG4105NBR Pectinesterase HVY12_RS06925 ENOG4107QM5 aconitate hydratase HVY12_RS06930 ENOG4107QPK )-transporter HVY12_RS06935 ENOG4105C7F AcnD-accessory protein PrpF HVY12_RS06940 ENOG4105F04 LysR family Transcriptional regulator HVY12_RS06950 ENOG4108K4B hydrolase HVY12_RS06960 ENOG4105E0C molybdate abc transporter HVY12_RS06965 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVY12_RS06975 ENOG4105F4R Transcriptional regulator mode HVY12_RS06980 ENOG4105DKW ABC transporter HVY12_RS06985 ENOG4105CMR udp-glucose 4-epimerase HVY12_RS06990 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVY12_RS07000 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVY12_RS07010 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY12_RS07015 ENOG4105JND homeobox protein HVY12_RS07020 ENOG4105PGM cation diffusion facilitator family transporter HVY12_RS07025 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY12_RS07030 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HVY12_RS07065 ENOG4105UFD tol-pal system protein YbgF HVY12_RS07070 ENOG4105KCK Peptidoglycan-associated lipoprotein HVY12_RS07080 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVY12_RS07090 ENOG4105E02 MotA TolQ exbB proton channel HVY12_RS07095 ENOG4107YD3 Thioesterase HVY12_RS07100 ENOG4105KJB cyd operon protein YbgE HVY12_RS07110 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY12_RS07115 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY12_RS07120 ENOG4107WFU Glutamate mutase subunit sigma HVY12_RS07130 ENOG4105DJI Methylaspartate mutase, E subunit HVY12_RS07150 ENOG4107GFK fumarate HVY12_RS07155 ENOG4105ETT transcriptional Regulator, LysR family HVY12_RS07170 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVY12_RS07180 ENOG4105C7S Dehydrogenase HVY12_RS07185 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVY12_RS07190 ENOG4105E33 succinate dehydrogenase HVY12_RS07195 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY12_RS07200 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVY12_RS07205 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVY12_RS07215 ENOG4105BZN citrate synthase HVY12_RS07220 ENOG4106UBK fimbrial-like adhesin protein HVY12_RS07225 ENOG4106PG1 outer membrane usher protein HVY12_RS07230 ENOG4108TTM chaperone HVY12_RS07235 ENOG4108MY7 Fimbrial HVY12_RS07240 ENOG4108KK1 membrane protein AbrB duplication HVY12_RS07255 ENOG4107R7A Allophanate hydrolase subunit 2 HVY12_RS07260 ENOG4105P4J Allophanate hydrolase, subunit 1 HVY12_RS07265 ENOG4107QNR UPF0135 protein HVY12_RS07270 ENOG4105DUX Transporter HVY12_RS07275 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVY12_RS07280 ENOG4107SEY Conserved Protein HVY12_RS07300 ENOG4105CNA YD repeat protein HVY12_RS07310 ENOG4105D70 Integrase catalytic subunit HVY12_RS07315 ENOG4105F5W AtP-binding protein HVY12_RS07320 ENOG4105XIQ Protein of unknown function (DUF2517) HVY12_RS07345 ENOG4105C08 Histidine kinase HVY12_RS07350 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVY12_RS07355 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVY12_RS07360 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVY12_RS07365 ENOG4105EV9 Alpha Beta Hydrolase HVY12_RS07370 ENOG4105NNH LexA regulated protein HVY12_RS07375 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVY12_RS07385 ENOG41090R7 Ferric uptake HVY12_RS07390 ENOG4105GX6 (LipO)protein HVY12_RS07405 ENOG4105CI1 PTS System HVY12_RS07415 ENOG4105CE4 GlcNAc 6-P deacetylase HVY12_RS07420 ENOG4105E2R ROK family HVY12_RS07425 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVY12_RS07430 ENOG4105CAQ asparagine synthetase HVY12_RS07475 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY12_RS07485 ENOG4105C9A Phoh family HVY12_RS07495 ENOG4108JU5 Magnesium and cobalt efflux protein HVY12_RS07500 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVY12_RS07505 ENOG4107RP9 extracellular solute-binding protein, family 3 HVY12_RS07510 ENOG4105EAD ABC transporter HVY12_RS07515 ENOG4105DRP amino acid AbC transporter HVY12_RS07520 ENOG4105CDA abc transporter atp-binding protein HVY12_RS07530 ENOG4105F7F Chaperone HVY12_RS07535 ENOG4105QFC Hsc56 co-chaperone of HscC HVY12_RS07540 ENOG41069CF Protein of unknown function (DUF1266) HVY12_RS07545 ENOG4107JFD Sel1 repeat HVY12_RS07555 ENOG4107PAI alpha helical protein HVY12_RS07570 ENOG4105DJF DNA polymerase III, delta' subunit HVY12_RS07580 ENOG4108TGR phosphatase HVY12_RS07585 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVY12_RS07595 ENOG4105CJN penicillin-binding protein HVY12_RS07600 ENOG4105CNI cell division protein FtsW HVY12_RS07605 ENOG4105K6T rare lipoprotein A HVY12_RS07610 ENOG4105DZ1 carboxypeptidase HVY12_RS07630 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HVY12_RS07655 ENOG4105CEE C4-dicarboxylate transporter HVY12_RS07660 ENOG4106YYS transcriptional regulatory protein HVY12_RS07665 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY12_RS07670 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVY12_RS07680 ENOG4105CI0 Citrate lyase HVY12_RS07685 ENOG4105CHY citrate lyase, alpha HVY12_RS07700 ENOG4107QPK )-transporter HVY12_RS07705 ENOG4105KTS ribonuclease HVY12_RS07710 ENOG4105NXH GreA GreB family elongation factor HVY12_RS07715 ENOG4108U51 Universal stress protein HVY12_RS07720 ENOG4108JU3 Alkyl hydroperoxide reductase HVY12_RS07725 ENOG4105D3R alkyl hydroperoxide reductase HVY12_RS07730 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVY12_RS07735 ENOG4105DQS Transcriptional regulator HVY12_RS07740 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVY12_RS07745 ENOG4105GTN ParB Domain Protein Nuclease HVY12_RS07750 ENOG4105CHM Aminotransferase HVY12_RS07755 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVY12_RS07760 ENOG4105VCD cytoplasmic protein HVY12_RS07765 ENOG4105D22 carbon starvation protein HVY12_RS07770 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVY12_RS07775 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVY12_RS07780 ENOG4105WQI isochorismatase HVY12_RS07785 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVY12_RS07790 ENOG4105E4F Isochorismate synthase HVY12_RS07795 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVY12_RS07805 ENOG4105DQ5 transport system permease protein HVY12_RS07810 ENOG4105TVJ transport system, permease HVY12_RS07815 ENOG4105E0A ABC, transporter HVY12_RS07820 ENOG4108QY5 Ferric enterobactin transport protein HVY12_RS07825 ENOG4105C0W non-ribosomal peptide synthetase HVY12_RS07830 ENOG41085A6 mbth domain-containing protein HVY12_RS07835 ENOG4105E93 esterase HVY12_RS07840 ENOG4107RNH Outer membrane receptor FepA HVY12_RS07845 ENOG4108TSE Transferase HVY12_RS07865 ENOG4105WQ6 Membrane HVY12_RS07870 ENOG4105MSB protein, conserved in bacteria HVY12_RS07875 ENOG4108RCM Nitroreductase HVY12_RS07880 ENOG4105CUY Mechanosensitive ion channel HVY12_RS07885 ENOG4105C85 amino acid HVY12_RS07890 ENOG4108IJF Heavy metal efflux pump, CzcA HVY12_RS07895 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVY12_RS07900 ENOG410624V efflux system protein HVY12_RS07905 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVY12_RS07910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY12_RS07915 ENOG4105GR3 Histidine kinase HVY12_RS07920 ENOG410802X bacteriophage n4 adsorption protein b HVY12_RS07925 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVY12_RS07930 ENOG4105QUW HVY12_RS07940 ENOG410814C multidrug resistance protein HVY12_RS07950 ENOG4108NC2 Outer membrane protease HVY12_RS07980 ENOG4108X9F tail fiber protein HVY12_RS08055 ENOG4105IM0 capsid protein HVY12_RS08065 ENOG4105F7J membrane-bound serine protease HVY12_RS08075 ENOG4107DE1 head-to-tail joining protein HVY12_RS08080 ENOG4105UZW Tail fiber assembly protein HVY12_RS08085 ENOG4105FKG DNA packaging protein HVY12_RS08090 ENOG4105QYK bacteriophage lambda Bor protein homolog HVY12_RS08100 ENOG4105KUS lysozyme HVY12_RS08105 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY12_RS08110 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HVY12_RS08115 ENOG4107SEY Conserved Protein HVY12_RS08125 ENOG4105HRS Antitermination protein HVY12_RS08140 ENOG4105RWQ Protein of unknown function (DUF1364) HVY12_RS08145 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVY12_RS08150 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVY12_RS08160 ENOG4108UQN AraC family transcriptional regulator HVY12_RS08165 ENOG4108V1U phospholipid-binding protein HVY12_RS08170 ENOG4107TII Recombinase HVY12_RS08180 ENOG410814C multidrug resistance protein HVY12_RS08265 ENOG4108KU3 Integrase HVY12_RS08280 ENOG4105WQ3 Rna-binding protein HVY12_RS08285 ENOG4105S2T inner membrane protein YbcI HVY12_RS08295 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY12_RS08310 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVY12_RS08315 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVY12_RS08320 ENOG4105C5B carbamate kinase HVY12_RS08325 ENOG4105G5A Protein of unknown function (DUF2877) HVY12_RS08330 ENOG4107REC cytoplasmic protein HVY12_RS08335 ENOG4107R1Q Membrane protein FdrA HVY12_RS08340 ENOG4105DG4 malate L-lactate dehydrogenase HVY12_RS08345 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVY12_RS08350 ENOG4105S0E allantoin catabolism protein HVY12_RS08355 ENOG4105BZW Glycerate kinase HVY12_RS08360 ENOG4105DTE Xanthine uracil vitamin C permease HVY12_RS08370 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVY12_RS08375 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY12_RS08380 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVY12_RS08385 ENOG41060W2 glyoxylate carboligase HVY12_RS08390 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVY12_RS08400 ENOG4107653 Transcriptional regulator HVY12_RS08410 ENOG4105CV6 ABC transporter, permease HVY12_RS08415 ENOG4108I0Y (ABC) transporter HVY12_RS08420 ENOG4108UJV acyl-CoA thioesterase i HVY12_RS08425 ENOG4105E1F short-chain dehydrogenase reductase HVY12_RS08430 ENOG4107QR8 Thioredoxin HVY12_RS08435 ENOG4105C4B ABC transporter, permease HVY12_RS08440 ENOG41083J0 (ABC) transporter HVY12_RS08445 ENOG4107QX8 SPFH domain, Band 7 family protein HVY12_RS08450 ENOG4105G5H Membrane HVY12_RS08475 ENOG4108Z6Z Transcriptional regulator HVY12_RS08480 ENOG4107QZV Type I secretion membrane fusion protein HVY12_RS08500 ENOG4107RY6 amino acid HVY12_RS08505 ENOG4105CSV Glutaminase HVY12_RS08510 ENOG4105C59 p-type ATPase HVY12_RS08515 ENOG4105MBR gumn family HVY12_RS08520 ENOG4108Z66 YbaK ebsC protein HVY12_RS08525 ENOG4105CGH 5'-nucleotidase HVY12_RS08530 ENOG4105EU0 Major facilitator Superfamily HVY12_RS08535 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVY12_RS08540 ENOG4107RE1 Inosine-guanosine kinase HVY12_RS08545 ENOG4105F2M alpha beta hydrolase fold-3 domain protein HVY12_RS08570 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HVY12_RS08575 ENOG4107QMP dna polymerase iii subunits gamma and tau HVY12_RS08585 ENOG4105WD1 Membrane HVY12_RS08590 ENOG4108URS primosomal replication protein n'' HVY12_RS08595 ENOG4106428 Protein of unknown function (DUF2496) HVY12_RS08600 ENOG4105EGS Mechanosensitive ion channel HVY12_RS08605 ENOG4107XI7 Tetr family transcriptional regulator HVY12_RS08610 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY12_RS08615 ENOG4105BZS acriflavin resistance protein HVY12_RS08620 ENOG4108UKR Biofilm formation regulator YbaJ HVY12_RS08630 ENOG4108UW5 maltose o-acetyltransferase HVY12_RS08635 ENOG4105GSJ Inner membrane protein ylaC HVY12_RS08640 ENOG41066DG (EAL) domain protein HVY12_RS08645 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVY12_RS08655 ENOG41080UX Methyltransferase HVY12_RS08660 ENOG4108MNP Glycoprotein polysaccharide metabolism HVY12_RS08665 ENOG4105C29 acyl-CoA thioesterase HVY12_RS08670 ENOG4105BZU Histidine kinase HVY12_RS08675 ENOG4108YZA Nitrogen regulatory protein pii HVY12_RS08680 ENOG4105BZ1 (ABC) transporter HVY12_RS08685 ENOG4105BZ1 (ABC) transporter HVY12_RS08690 ENOG4108XM1 transcriptional regulator AsnC family HVY12_RS08700 ENOG4108NFA extracellular solute-binding protein HVY12_RS08710 ENOG4108TGP Thioesterase superfamily protein HVY12_RS08715 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVY12_RS08720 ENOG4105EIN peptidylprolyl cis-trans isomerase HVY12_RS08725 ENOG4105K70 DNA-binding protein HVY12_RS08730 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVY12_RS08750 ENOG4105M85 Bola protein HVY12_RS08755 ENOG4105IEY (LipO)protein HVY12_RS08760 ENOG4105EYM Major Facilitator superfamily HVY12_RS08765 ENOG4105E2S oxidase) subunit II HVY12_RS08770 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVY12_RS08775 ENOG4105CCU oxidase (Subunit III) HVY12_RS08780 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVY12_RS08790 ENOG4107RDB Major Facilitator HVY12_RS08800 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVY12_RS08805 ENOG4107S0N DJ-1 family HVY12_RS08820 ENOG4105CTB Polyprenyl synthetase HVY12_RS08825 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVY12_RS08830 ENOG4105CPC Aldo Keto reductase HVY12_RS08835 ENOG4108ZAI phosphatidylglycerophosphatase a HVY12_RS08840 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVY12_RS08850 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVY12_RS08855 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVY12_RS08865 ENOG4108KIC (LipO)protein HVY12_RS08870 ENOG4105DRB nucleoside-specific channel-forming protein HVY12_RS08875 ENOG4105N1F Hnh endonuclease HVY12_RS08885 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY12_RS08890 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY12_RS08895 ENOG4105VIE preprotein translocase, subunit YajC HVY12_RS08905 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HVY12_RS08910 ENOG4108ZYK Acyl carrier protein phosphodiesterase HVY12_RS08915 ENOG4107R28 alpha amylase, catalytic region HVY12_RS08920 ENOG4105C85 amino acid HVY12_RS08925 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVY12_RS08930 ENOG4105BZU Histidine kinase HVY12_RS08935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY12_RS08940 ENOG4107RH8 nuclease SbcCD subunit D HVY12_RS08945 ENOG4105EYH Exonuclease HVY12_RS08950 ENOG4105F27 Major Facilitator HVY12_RS08955 ENOG4105DKQ ROK family HVY12_RS08970 ENOG4105HBA AroM protein HVY12_RS08975 ENOG4105SS3 HVY12_RS08990 ENOG4105II7 pyrroline-5-carboxylate reductase HVY12_RS08995 ENOG4105BZU Histidine kinase HVY12_RS09000 ENOG4105VIF phosphate starvation-inducible protein HVY12_RS09005 ENOG4105G6Z alkaline phosphatase HVY12_RS09015 ENOG4105CPF Cell wall formation (By similarity) HVY12_RS09020 ENOG4105UNH Membrane HVY12_RS09025 ENOG4105FR5 inner membrane protein YaiY HVY12_RS09030 ENOG4107QS8 (LipO)protein HVY12_RS09035 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVY12_RS09040 ENOG4107R6D beta-lactam binding protein AmpH HVY12_RS09045 ENOG4108PNB DNA-binding transcriptional regulator HVY12_RS09055 ENOG4105D52 delta-aminolevulinic acid dehydratase HVY12_RS09060 ENOG4105E2B Taurine dioxygenase HVY12_RS09065 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVY12_RS09075 ENOG4106FTQ Taurine ABC transporter, periplasmic HVY12_RS09080 ENOG4107W19 lmbE family HVY12_RS09085 ENOG4108PBI Polysaccharide metabolism HVY12_RS09095 ENOG4105SRB Uncharacterized protein yaiO HVY12_RS09110 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVY12_RS09115 ENOG4108SC4 )-transporter HVY12_RS09150 ENOG4108K2P TRANSCRIPTIONal HVY12_RS09155 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HVY12_RS09165 ENOG4105ETE Transcriptional regulator (LacI family HVY12_RS09175 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVY12_RS09180 ENOG4108UW5 maltose o-acetyltransferase HVY12_RS09185 ENOG4105DZC cytosine deaminase HVY12_RS09190 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVY12_RS09200 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY12_RS09205 ENOG4105DXD 2-methylcitrate dehydratase HVY12_RS09210 ENOG4105BZN citrate synthase HVY12_RS09215 ENOG4105CR4 methylisocitrate lyase HVY12_RS09220 ENOG4108JU7 Transcriptional regulator HVY12_RS09225 ENOG4105TDT uncharacterized protein yahO HVY12_RS09235 ENOG4105E82 cytochrome subunit of dehydrogenase HVY12_RS09240 ENOG4105C0D helicase HVY12_RS09265 ENOG4105DZC cytosine deaminase HVY12_RS09270 ENOG4105C5B carbamate kinase HVY12_RS09275 ENOG4107REC cytoplasmic protein HVY12_RS09280 ENOG4107R1Q Membrane protein FdrA HVY12_RS09285 ENOG4105N16 Protein of unknown function (DUF2877) HVY12_RS09290 ENOG4107SNB ankyrin repeat protein YahD HVY12_RS09295 ENOG4105SZ2 membrAne HVY12_RS09300 ENOG4108NUU Transcriptional regulator HVY12_RS09305 ENOG4105BZU Histidine kinase HVY12_RS09310 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVY12_RS09315 ENOG4107QR9 Iron-sulfur cluster binding protein HVY12_RS09320 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY12_RS09330 ENOG4108K01 transcriptional regulator HVY12_RS09335 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY12_RS09340 ENOG41066GK UPF0379 protein ykgI HVY12_RS09345 ENOG4108KBJ Inner membrane protein YkgB HVY12_RS09350 ENOG4105ENX hydrolase HVY12_RS09370 ENOG4105GR3 Histidine kinase HVY12_RS09390 ENOG4105DQ4 alcohol dehydrogenase HVY12_RS09395 ENOG4105CV8 reductase HVY12_RS09405 ENOG4107SET aldo keto reductase HVY12_RS09410 ENOG4105EQ2 LysR family Transcriptional regulator HVY12_RS09460 ENOG4105E0A ABC, transporter HVY12_RS09465 ENOG4105EHG Permease protein HVY12_RS09470 ENOG4105S10 periplasmic binding protein HVY12_RS09475 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HVY12_RS09480 ENOG4105R3P Inner membrane protein yagU HVY12_RS09505 ENOG4105FCK Membrane HVY12_RS09515 ENOG4105V1F Fermentation respiration switch protein HVY12_RS09525 ENOG4105CIN aminoacyl-histidine dipeptidase HVY12_RS09540 ENOG4108S2Y peptide Chain Release factor HVY12_RS09550 ENOG4108HYG acetyltransferase HVY12_RS09555 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVY12_RS09570 ENOG4108UK5 Transposase HVY12_RS09575 ENOG4108YS0 lipoprotein YafL HVY12_RS09580 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVY12_RS09585 ENOG4105E7A Glutamine amidotransferase HVY12_RS09595 ENOG4107QPN acyl-Coa dehydrogenase HVY12_RS09600 ENOG4108WN0 inhibitor of vertebrate lysozyme HVY12_RS09605 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY12_RS09625 ENOG4105CS6 Rhs element vgr protein HVY12_RS09650 ENOG41090EK ompa motb domain protein HVY12_RS09660 ENOG4105D70 Integrase catalytic subunit HVY12_RS09665 ENOG4105F5W AtP-binding protein HVY12_RS09705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY12_RS09745 ENOG4107RZZ dna polymerase iii epsilon subunit HVY12_RS09755 ENOG4105D1A Methyltransferase HVY12_RS09765 ENOG4105E9H Lytic Murein transglycosylase HVY12_RS09770 ENOG4105F2W methyltransferase HVY12_RS09785 ENOG4105D70 Integrase catalytic subunit HVY12_RS09790 ENOG4105F5W AtP-binding protein HVY12_RS09800 ENOG4105CV8 reductase HVY12_RS09835 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVY12_RS09840 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVY12_RS09845 ENOG4108UMI ABC transporter, permease HVY12_RS09850 ENOG4105D01 (LipO)protein HVY12_RS09855 ENOG4108R8X outer membrane lipoprotein HVY12_RS09860 ENOG4108R96 Methyltransferase, YaeB family HVY12_RS09870 ENOG4108UY0 (LipO)protein HVY12_RS09875 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVY12_RS09880 ENOG4108YZN class I peptide chain release factor HVY12_RS09885 ENOG4108VWS Yaeq family HVY12_RS09895 ENOG4105M1T rho-binding antiterminator HVY12_RS09900 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVY12_RS09905 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVY12_RS09920 ENOG4105C0B DNA polymerase III (alpha subunit) HVY12_RS09945 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVY12_RS09950 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVY12_RS09960 ENOG4105DZP Membrane-associated zinc metalloprotease HVY12_RS09965 ENOG4105KNE Phosphatidate cytidylyltransferase HVY12_RS09970 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVY12_RS09975 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVY12_RS09980 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HVY12_RS10000 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVY12_RS10015 ENOG4105DIN metallophosphoesterase HVY12_RS10025 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVY12_RS10030 ENOG4105C0H protease HVY12_RS10045 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVY12_RS10050 ENOG4105EN6 Membrane HVY12_RS10075 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVY12_RS10080 ENOG4105J76 Periplasmic binding protein HVY12_RS10085 ENOG4105E0A ABC, transporter HVY12_RS10090 ENOG4105E0K tonB-dependent siderophore receptor HVY12_RS10095 ENOG4105BZ4 penicillin-binding protein HVY12_RS10100 ENOG4105CQ7 ATP-dependent helicase HVY12_RS10105 ENOG4107XID 2'-5' rna ligase HVY12_RS10125 ENOG4105DJ0 Poly(A) Polymerase HVY12_RS10130 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVY12_RS10140 ENOG4108VEV chaperone HVY12_RS10145 ENOG4105CW0 outer membrane usher protein HVY12_RS10155 ENOG4105SYG Fimbrial protein HVY12_RS10160 ENOG4105SN2 fimbrial-like adhesin protein HVY12_RS10170 ENOG4105P0Q fimbrial-like protein YadC HVY12_RS10175 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HVY12_RS10180 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HVY12_RS10185 ENOG4108A32 Transposase HVY12_RS10190 ENOG4108A32 Transposase HVY12_RS10200 ENOG4107BJW polysaccharide deacetylase HVY12_RS10205 ENOG4108YTN IIa component HVY12_RS10210 ENOG4105E3A (ABC) transporter HVY12_RS10215 ENOG4105DA5 (ABC) transporter HVY12_RS10220 ENOG41077A9 carbonic anhydrase HVY12_RS10225 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVY12_RS10230 ENOG4105DZG Dehydrogenase HVY12_RS10235 ENOG4105E3B Multicopper oxidase HVY12_RS10240 ENOG4108ZRK uncharacterized protein yacC HVY12_RS10265 ENOG4107QIJ Aconitate hydratase 2 HVY12_RS10270 ENOG4108NST exported protein HVY12_RS10270 ENOG4108NST exported protein HVY12_RS10275 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY12_RS10280 ENOG4107QSN dihydrolipoamide acetyltransferase HVY12_RS10285 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVY12_RS10290 ENOG41073TP transcriptional regulator HVY12_RS10295 ENOG4105C85 amino acid HVY12_RS10300 ENOG4106A72 regulatory protein AmpE HVY12_RS10305 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY12_RS10310 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVY12_RS10315 ENOG4108ZUW Major pilin subunit HVY12_RS10320 ENOG4107QHF type ii secretion system protein e HVY12_RS10325 ENOG4105D7Q type ii secretion system HVY12_RS10340 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVY12_RS10355 ENOG4105M6F mutator MutT protein HVY12_RS10375 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVY12_RS10380 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVY12_RS10385 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVY12_RS10390 ENOG4105CPF Cell wall formation (By similarity) HVY12_RS10405 ENOG4105CNI cell division protein FtsW HVY12_RS10410 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVY12_RS10420 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVY12_RS10425 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVY12_RS10430 ENOG4105CJN penicillin-binding protein HVY12_RS10435 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVY12_RS10450 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVY12_RS10460 ENOG4108ZP8 Acetolactate synthase small subunit HVY12_RS10465 ENOG4105C7K acetolactate synthase HVY12_RS10470 ENOG41064T2 transcriptional regulator, lysR family HVY12_RS10505 ENOG4105DP9 ABC transporter HVY12_RS10510 ENOG4106SMU thiamine transporter membrane protein HVY12_RS10515 ENOG4107T0D ABC, transporter HVY12_RS10520 ENOG4108KF1 Membrane HVY12_RS10525 ENOG41063TF transcriptional regulator (AraC HVY12_RS10545 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY12_RS10550 ENOG4105CQ2 DNA polymerase HVY12_RS10555 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVY12_RS10560 ENOG4105D3G Pseudouridine synthase HVY12_RS10565 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVY12_RS10575 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVY12_RS10600 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVY12_RS10610 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HVY12_RS10615 ENOG4105C54 Major Facilitator superfamily HVY12_RS10620 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVY12_RS10625 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVY12_RS10660 ENOG4106YT9 Enoyl-CoA hydratase HVY12_RS10665 ENOG4108Z0R Transferase HVY12_RS10670 ENOG4108XNW Transcriptional activatory protein CaiF HVY12_RS10675 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVY12_RS10680 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVY12_RS10700 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVY12_RS10710 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HVY12_RS10715 ENOG4105DTN riboflavin biosynthesis protein ribF HVY12_RS10730 ENOG41063Z6 transcriptional regulator, lysR family HVY12_RS10735 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HVY12_RS10740 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVY12_RS10760 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVY12_RS10765 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY12_RS10775 ENOG4105BZG amino acid carrier protein HVY12_RS10785 ENOG41062C6 Protein of unknown function (DUF2502) HVY12_RS10790 ENOG4105D98 threonine synthase HVY12_RS10800 ENOG4105CFH Aspartokinase HVY12_RS10810 ENOG4106FVC RNA methyltransferase HVY12_RS10815 ENOG410759A HVY12_RS10820 ENOG41065U4 response regulator HVY12_RS10825 ENOG4105CT7 inner membrane cred family protein HVY12_RS10830 ENOG4105EB3 Histidine kinase HVY12_RS10835 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY12_RS10840 ENOG4108RH0 Crea protein HVY12_RS10845 ENOG4105UEI Transcriptional Regulator AraC Family HVY12_RS10865 ENOG4107SC1 transglycosylase HVY12_RS10870 ENOG4105C5H ABC transporter HVY12_RS10875 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVY12_RS10880 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVY12_RS10885 ENOG4105EAC phosphoserine phosphatase HVY12_RS10890 ENOG41062Z9 Membrane HVY12_RS10905 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HVY12_RS10925 ENOG4105G0K glycine radical enzyme YjjI family HVY12_RS10930 ENOG41076CZ activating enzyme HVY12_RS10935 ENOG4105EYA deoxyribonuclease HVY12_RS10940 ENOG4108NRW Phospholipase, patatin family HVY12_RS10950 ENOG4105K3G Periplasmic Protein HVY12_RS10960 ENOG4105PAD Hydrolase HVY12_RS10965 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVY12_RS10970 ENOG4108WPU DNA polymerase III subunit psi HVY12_RS10995 ENOG4105YBH Protein of unknown function (DUF1435) HVY12_RS11000 ENOG4108819 ferric iron reductase HVY12_RS11005 ENOG4108T94 DNA-binding transcriptional activator BglJ HVY12_RS11010 ENOG4108N8T regulatoR HVY12_RS11015 ENOG4105DWK Membrane HVY12_RS11030 ENOG4106CVF DNA replication protein HVY12_RS11035 ENOG4105RI1 glycoprotein receptor HVY12_RS11045 ENOG4105CPQ Dehydrogenase HVY12_RS11050 ENOG410617M Transcriptional regulator HVY12_RS11055 ENOG4105EEQ Na H antiporter HVY12_RS11060 ENOG4108ERU trap dicarboxylate transporter subunit DctP HVY12_RS11070 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY12_RS11075 ENOG4105C8Q Methyl-accepting chemotaxis HVY12_RS11080 ENOG4105D22 carbon starvation protein HVY12_RS11085 ENOG4105VCD cytoplasmic protein HVY12_RS11090 ENOG4105CKI cobalamin synthesis protein HVY12_RS11105 ENOG4106H3A restriction HVY12_RS11110 ENOG4105CVR type I restriction-modification system HVY12_RS11115 ENOG4105EKX Restriction modification system DNA (Specificity HVY12_RS11120 ENOG4105DZR Type I site-specific deoxyribonuclease HVY12_RS11130 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY12_RS11140 ENOG4106BRA Membrane HVY12_RS11145 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVY12_RS11150 ENOG4105CIZ coA-substrate-specific enzyme activase HVY12_RS11165 ENOG4105CBP Major Facilitator HVY12_RS11180 ENOG4105DYB Isoaspartyl dipeptidase HVY12_RS11190 ENOG4105DFD Na H antiporter HVY12_RS11200 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVY12_RS11205 ENOG41060W2 glyoxylate carboligase HVY12_RS11210 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVY12_RS11215 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY12_RS11220 ENOG4105BZW Glycerate kinase HVY12_RS11225 ENOG4105C94 Transporter HVY12_RS11230 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY12_RS11245 ENOG4105CMT Dihydroxyacetone kinase HVY12_RS11250 ENOG4108UTZ Dihydroxyacetone kinase HVY12_RS11265 ENOG4105ZIA Phage protein gp16 HVY12_RS11295 ENOG4105IKI host-nuclease inhibitor protein HVY12_RS11385 ENOG4105CF2 Mu-like prophage FluMu protein GP28 HVY12_RS11395 ENOG4108QUU Morphogenesis Protein HVY12_RS11505 ENOG4108US3 tail fiber assembly HVY12_RS11525 ENOG4108C33 Resolvase HVY12_RS11530 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY12_RS11540 ENOG4105C6F GntR Family Transcriptional Regulator HVY12_RS11545 ENOG4105DEI Mannitol dehydrogenase HVY12_RS11555 ENOG4107EFN gluconate transport system permease 3 HVY12_RS11560 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HVY12_RS11565 ENOG4108T65 Fimbrial HVY12_RS11570 ENOG4108SQA Fimbrial HVY12_RS11575 ENOG4105CW0 outer membrane usher protein HVY12_RS11580 ENOG4108NAE Fimbrial chaperone protein HVY12_RS11585 ENOG4108S54 Fimbrial protein HVY12_RS11595 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HVY12_RS11600 ENOG4108W9T type 1 fimbriae regulatory protein HVY12_RS11605 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HVY12_RS11655 ENOG4105D7A ATP-binding protein HVY12_RS11660 ENOG4108K5H permease YjgP YjgQ family protein HVY12_RS11665 ENOG4108M8S permease YjgP YjgQ family protein HVY12_RS11675 ENOG4105MYG DNA polymerase iii, chi subunit HVY12_RS11680 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVY12_RS11685 ENOG4108M3P Membrane HVY12_RS11690 ENOG4108MJ3 acetyltransferase HVY12_RS11695 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVY12_RS11705 ENOG4105XEP YhcH YjgK YiaL family protein HVY12_RS11710 ENOG4107C93 pyrBI operon leader peptide HVY12_RS11725 ENOG4105KME endoribonuclease L-psp HVY12_RS11735 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HVY12_RS11745 ENOG4105D4X repressor HVY12_RS11750 ENOG4105C5Y PTS System HVY12_RS11755 ENOG4105CG3 alpha amylase, catalytic region HVY12_RS11760 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVY12_RS11765 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVY12_RS11785 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVY12_RS11795 ENOG4105DFU Cell wall formation (By similarity) HVY12_RS11810 ENOG41062B0 ABC transporter, permease HVY12_RS11815 ENOG4107R9N ABC transporter HVY12_RS11820 ENOG4105C2J ABC transporter HVY12_RS11825 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVY12_RS11830 ENOG4105F0N pyrophosphate phospho-hydrolase HVY12_RS11835 ENOG4105C5Y PTS System HVY12_RS11840 ENOG4105CS2 ec 3.2.1.21 HVY12_RS11845 ENOG4105CID antiterminator HVY12_RS11850 ENOG4108ZHD aig2 family HVY12_RS11855 ENOG4105MA0 exported protein HVY12_RS11860 ENOG4105CFU surface antigen HVY12_RS11870 ENOG4105C37 (CBS) domain HVY12_RS11875 ENOG41061GZ Protein of unknown function (DUF1107) HVY12_RS11880 ENOG4108UUE Transcriptional regulator HVY12_RS11885 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVY12_RS11890 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVY12_RS11895 ENOG4105KVH Transcriptional regulator HVY12_RS11900 ENOG4105ECR NmrA family HVY12_RS11905 ENOG4105DXC membrane HVY12_RS11930 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY12_RS11935 ENOG4105FHY Opacity-associated protein A HVY12_RS11945 ENOG4105CHR reductase HVY12_RS11955 ENOG4105E39 Enoyl-CoA hydratase HVY12_RS11960 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVY12_RS11965 ENOG4107S3R L-aspartate oxidase HVY12_RS11970 ENOG4105DPW Major facilitator superfamily MFS_1 HVY12_RS11980 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVY12_RS11985 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HVY12_RS11995 ENOG4105KIT UPF0379 protein yjfY HVY12_RS12020 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVY12_RS12025 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY12_RS12040 ENOG4108MXZ Esterase HVY12_RS12045 ENOG4105WSB biofilm stress and motility protein A HVY12_RS12050 ENOG4105S17 UPF0379 protein yjfN HVY12_RS12055 ENOG4105CSU acyl-Coa dehydrogenase HVY12_RS12060 ENOG4106032 Glutathionylspermidine synthase HVY12_RS12065 ENOG4108KXT Conserved Protein HVY12_RS12070 ENOG4105Z6B inner membrane protein yjfl HVY12_RS12075 ENOG4107VNS Protein of unknown function (DUF2491) HVY12_RS12080 ENOG4108P9J Phage shock protein A HVY12_RS12085 ENOG4105FUX Conserved Protein HVY12_RS12090 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVY12_RS12095 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVY12_RS12115 ENOG4105EPW hflc protein HVY12_RS12120 ENOG4107QJR hflk protein HVY12_RS12125 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVY12_RS12145 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY12_RS12150 ENOG4105K8N protein family UPF0079, ATPase HVY12_RS12155 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVY12_RS12195 ENOG4105EGS Mechanosensitive ion channel HVY12_RS12200 ENOG4106CG8 Inner membrane protein YjeO HVY12_RS12205 ENOG4106V5W HVY12_RS12210 ENOG4107SC7 Inner membrane transporter yjeM HVY12_RS12215 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HVY12_RS12220 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY12_RS12225 ENOG4105E33 succinate dehydrogenase HVY12_RS12240 ENOG41066YJ Beta-lactamase HVY12_RS12245 ENOG4105QNF Outer membrane lipoprotein HVY12_RS12250 ENOG4105KPY Small multidrug resistance protein HVY12_RS12255 ENOG4106BSU Entericidin B HVY12_RS12260 ENOG4107PEH Entericidin EcnA/B family HVY12_RS12270 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVY12_RS12275 ENOG4105MTB Uncharacterized protein YjeJ HVY12_RS12280 ENOG4108ZVF (LipO)protein HVY12_RS12295 ENOG4105DVH amino acid HVY12_RS12300 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVY12_RS12305 ENOG4108IJ0 Aspartate ammonia-lyase HVY12_RS12310 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY12_RS12320 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVY12_RS12325 ENOG4108SIC Transcriptional regulator HVY12_RS12335 ENOG4108M3R transcriptional activator CadC HVY12_RS12340 ENOG4105D5Q Arginine ornithine antiporter HVY12_RS12345 ENOG4105CXN decarboxylase HVY12_RS12350 ENOG4105DUX Transporter HVY12_RS12355 ENOG4105CRK lysyL-tRNA synthetase HVY12_RS12370 ENOG410830R acetyltransferase HVY12_RS12375 ENOG4105VR1 Pfam:DUF1271 HVY12_RS12380 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY12_RS12385 ENOG4108MRH transcriptional regulatory protein HVY12_RS12390 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY12_RS12395 ENOG4107GFK fumarate HVY12_RS12400 ENOG4108R5S membrane HVY12_RS12405 ENOG4105CT4 transporter HVY12_RS12410 ENOG4105F8D glycoside hydrolase family 4 HVY12_RS12415 ENOG4108K2B transcriptional regulator HVY12_RS12420 ENOG4105CXN decarboxylase HVY12_RS12425 ENOG4106ZGR Transcriptional regulator HVY12_RS12430 ENOG4105D5Q Arginine ornithine antiporter HVY12_RS12435 ENOG4105DIJ Phosphoethanolamine transferase HVY12_RS12440 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY12_RS12445 ENOG4105ECM Sensor protein basS pmrB HVY12_RS12455 ENOG4105CSH Transporter HVY12_RS12460 ENOG4108YIV HVY12_RS12465 ENOG4108F5E vimentin HVY12_RS12470 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVY12_RS12480 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVY12_RS12490 ENOG4108YZG isomerase HVY12_RS12495 ENOG4105EUZ Beta-lactamase domain protein HVY12_RS12505 ENOG4105J12 Multidrug resistance protein mdtN HVY12_RS12510 ENOG4108MI0 Resistance protein HVY12_RS12515 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVY12_RS12530 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY12_RS12535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY12_RS12545 ENOG4108JQ7 (ABC) transporter HVY12_RS12550 ENOG41082ND Uncharacterized protein yjcO HVY12_RS12555 ENOG4105CK2 sodium dicarboxylate symporter HVY12_RS12560 ENOG4108W0S formate-dependent nitrite reductase complex HVY12_RS12570 ENOG4108QKW cytochrome c-type biogenesis protein HVY12_RS12575 ENOG4105DVI reductase, NrfD HVY12_RS12580 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY12_RS12585 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVY12_RS12595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY12_RS12600 ENOG41062QD Membrane HVY12_RS12610 ENOG4105EEQ Na H antiporter HVY12_RS12615 ENOG4105C7N Xanthine uracil vitamin C permease HVY12_RS12620 ENOG4108Z4X TRANSCRIPTIONal HVY12_RS12625 ENOG4108W3Q Transcriptional regulator HVY12_RS12630 ENOG4108M8H domain protein HVY12_RS12635 ENOG4105PMV Membrane HVY12_RS12640 ENOG4108UUM single-stranded DNA-binding protein HVY12_RS12645 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVY12_RS12650 ENOG4105MSB protein, conserved in bacteria HVY12_RS12655 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVY12_RS12660 ENOG4105F0S class B acid phosphatase HVY12_RS12665 ENOG4105CGF Aromatic amino acid aminotransferase HVY12_RS12670 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY12_RS12675 ENOG4105CDU Replicative dna helicase HVY12_RS12680 ENOG4105ETE Transcriptional regulator (LacI family HVY12_RS12685 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVY12_RS12690 ENOG4106YT9 Enoyl-CoA hydratase HVY12_RS12700 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY12_RS12705 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVY12_RS12710 ENOG4105P4Z Phage shock protein G HVY12_RS12715 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY12_RS12720 ENOG4105MYN Zinc uptake regulation protein HVY12_RS12725 ENOG4105VDW Csbd family HVY12_RS12730 ENOG4107R73 Mate efflux family protein HVY12_RS12740 ENOG41080IJ Diacylglycerol kinase HVY12_RS12760 ENOG4107W52 maltose operon periplasmic protein HVY12_RS12770 ENOG4108IJ9 (ABC) transporter HVY12_RS12775 ENOG4107FKK extracellular solute-binding protein family 1 HVY12_RS12780 ENOG4105D56 permease protein HVY12_RS12785 ENOG4105EG2 ABC transporter, permease HVY12_RS12800 ENOG4105E3R (LipO)protein HVY12_RS12805 ENOG4108Q9C Periplasmic Protein HVY12_RS12810 ENOG4108MDC (LipO)protein HVY12_RS12820 ENOG4107QP8 phosphohexose isomerase HVY12_RS12825 ENOG4105CFH Aspartokinase HVY12_RS12830 ENOG410756H nucleotidyltransferase HVY12_RS12835 ENOG4108ZR5 Conserved Protein HVY12_RS12840 ENOG4105FE9 pseudouridine synthase HVY12_RS12855 ENOG4105EAM Na Pi-cotransporter HVY12_RS12860 ENOG4105C3R Methionine synthase HVY12_RS12865 ENOG41069M3 Transcriptional regulator HVY12_RS12875 ENOG4108I9X Isocitrate lyase HVY12_RS12880 ENOG4107QP3 malate synthase g HVY12_RS12890 ENOG4105K5X acetyltransferase HVY12_RS12920 ENOG4105C12 Phosphoribosylglycinamide synthetase HVY12_RS12925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY12_RS12930 ENOG4105BZU Histidine kinase HVY12_RS12935 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVY12_RS12940 ENOG4108T8B Protein of unknown function (DUF1481) HVY12_RS12950 ENOG4105R2J Conserved Protein HVY12_RS12975 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HVY12_RS12985 ENOG4105D06 uba thif-type nad fad binding protein HVY12_RS12990 ENOG4105WHD thiamine biosynthesis protein ThiS HVY12_RS13000 ENOG4105D41 biosynthesis protein thiH HVY12_RS13035 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVY12_RS13040 ENOG4105PM1 preprotein translocase subunit SecE HVY12_RS13075 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVY12_RS13115 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVY12_RS13125 ENOG4108Y73 Membrane HVY12_RS13130 ENOG4105EJ2 Transcriptional regulator HVY12_RS13140 ENOG4105CH2 amidohydrolase HVY12_RS13150 ENOG4105C5Q Transcriptional regulator HVY12_RS13155 ENOG4108I5G Major Facilitator superfamily HVY12_RS13160 ENOG4105CXK mandelate racemase muconate lactonizing HVY12_RS13175 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVY12_RS13200 ENOG4105DIJ Phosphoethanolamine transferase HVY12_RS13205 ENOG4106R3P AraC family transcriptional regulator HVY12_RS13210 ENOG4108XCZ PTS System HVY12_RS13215 ENOG4108AHH pyruvate formate lyase II activase HVY12_RS13225 ENOG4108YRF PTS System HVY12_RS13230 ENOG4105DM4 PTS System HVY12_RS13235 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY12_RS13240 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY12_RS13245 ENOG4105DCT glycerol dehydrogenase HVY12_RS13250 ENOG4108XC3 NADH ubiquinone oxidoreductase HVY12_RS13255 ENOG4108Q5Y Membrane HVY12_RS13265 ENOG4105SYT Methylenetetrahydrofolate reductase HVY12_RS13270 ENOG4105CFH Aspartokinase HVY12_RS13275 ENOG4105C28 cystathionine HVY12_RS13285 ENOG4107S01 Repressor protein MetJ HVY12_RS13290 ENOG4105CXY transporter HVY12_RS13300 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HVY12_RS13310 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HVY12_RS13320 ENOG4105C25 Primosomal protein n' HVY12_RS13325 ENOG4105ETE Transcriptional regulator (LacI family HVY12_RS13330 ENOG41063M6 Cell Division Protein HVY12_RS13345 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVY12_RS13370 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY12_RS13380 ENOG4105CBT Fructose-1,6-bisphosphatase HVY12_RS13385 ENOG4105DP0 ferredoxin-NADP reductase HVY12_RS13395 ENOG41065TG regulatoR HVY12_RS13400 ENOG4108VTS Membrane HVY12_RS13405 ENOG4105EBK exported protein HVY12_RS13420 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVY12_RS13435 ENOG4105FMW periplasmic HVY12_RS13440 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY12_RS13445 ENOG4105E0F Histidine kinase HVY12_RS13450 ENOG4108RPX mosc domain containing protein HVY12_RS13455 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HVY12_RS13465 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY12_RS13495 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HVY12_RS13510 ENOG4105C26 Dehydrogenase HVY12_RS13515 ENOG4105C0A alcohol dehydrogenase HVY12_RS13520 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVY12_RS13530 ENOG4108U78 Glutathione S-transferase HVY12_RS13545 ENOG4105EFX secretion protein, HlyD family HVY12_RS13550 ENOG4105FP6 Protein of unknown function (DUF3302) HVY12_RS13555 ENOG4105CTS PTS system mannitol-specific HVY12_RS13565 ENOG4105E61 Mannitol repressor protein HVY12_RS13575 ENOG4108YYI Protein of unknown function (DUF2810) HVY12_RS13585 ENOG4108WY4 inner membrane lipoprotein HVY12_RS13595 ENOG4105DAA L-lactate HVY12_RS13600 ENOG41073TP transcriptional regulator HVY12_RS13610 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVY12_RS13615 ENOG4105D7W serine acetyltransferase HVY12_RS13630 ENOG4105VW4 glutaredoxin 3 HVY12_RS13635 ENOG4107YZP Rhodanese domain protein HVY12_RS13645 ENOG41063SB peptidase HVY12_RS13650 ENOG4105PXI polysaccharide deacetylase HVY12_RS13655 ENOG4105K64 Glycosyl transferase, family 2 HVY12_RS13660 ENOG4105CPQ Dehydrogenase HVY12_RS13665 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVY12_RS13675 ENOG4105XA0 heptosyltransferase ii HVY12_RS13680 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVY12_RS13685 ENOG41068PG O-Antigen polymerase HVY12_RS13690 ENOG4108XNZ glycosyl transferase HVY12_RS13695 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVY12_RS13700 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVY12_RS13705 ENOG4105X1N Glycosyl transferase family 8 HVY12_RS13710 ENOG4106AH0 Glycosyl Transferase HVY12_RS13715 ENOG4107XU6 Glycosyl transferase (Group 1 HVY12_RS13720 ENOG410650X lipopolysaccharide core region biosynthetic process HVY12_RS13725 ENOG4107543 (lipo)polysaccharide HVY12_RS13730 ENOG4107RJ7 Glycosyl transferase (Group 1 HVY12_RS13735 ENOG4105DKP glycosyl transferase, family 9 HVY12_RS13740 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVY12_RS13760 ENOG4105KDC 50s ribosomal protein l28 HVY12_RS13770 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVY12_RS13775 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVY12_RS13795 ENOG4105DSJ YicC domain protein HVY12_RS13800 ENOG4105EN6 Membrane HVY12_RS13810 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVY12_RS13820 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY12_RS13825 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVY12_RS13830 ENOG4105CB5 ATP-dependent DNA helicase recG HVY12_RS13835 ENOG4105D6U Sodium Glutamate Symporter HVY12_RS13840 ENOG4105C2W permease HVY12_RS13845 ENOG4105JV1 AsmA family HVY12_RS13850 ENOG4105CJQ hydrolase, family 31 HVY12_RS13855 ENOG4105CT4 transporter HVY12_RS13870 ENOG4105D70 Integrase catalytic subunit HVY12_RS13875 ENOG4105F5W AtP-binding protein HVY12_RS13950 ENOG4108C80 FliB family HVY12_RS13955 ENOG4108UZ3 Transporter HVY12_RS13960 ENOG4105D01 (LipO)protein HVY12_RS13965 ENOG4105T8A Uncharacterized protein YicS HVY12_RS13975 ENOG4108SAJ Protein of unknown function (DUF1198) HVY12_RS13980 ENOG4105C7N Xanthine uracil vitamin C permease HVY12_RS13990 ENOG4105CXY transporter HVY12_RS13995 ENOG4105CXY transporter HVY12_RS14000 ENOG4105BZU Histidine kinase HVY12_RS14005 ENOG4108KX4 response regulator HVY12_RS14010 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVY12_RS14015 ENOG4105C7K acetolactate synthase HVY12_RS14025 ENOG4105E5M Multidrug resistance protein D HVY12_RS14030 ENOG4105J13 transcriptional regulator HVY12_RS14035 ENOG4105JP4 Inner membrane protein yidG HVY12_RS14040 ENOG4105VG5 Membrane HVY12_RS14045 ENOG4106DRA Inner membrane protein YidI HVY12_RS14055 ENOG4105D0C transport protein HVY12_RS14070 ENOG4105R2A (LipO)protein HVY12_RS14075 ENOG4105D99 atp gtp-binding protein HVY12_RS14085 ENOG4105DJB Major Facilitator Superfamily HVY12_RS14095 ENOG4108RTU Aldolase HVY12_RS14100 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVY12_RS14105 ENOG4105EMF GntR family transcriptional regulator HVY12_RS14110 ENOG410657R replicase EC 2.7 HVY12_RS14115 ENOG410667J hydrolase HVY12_RS14120 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVY12_RS14125 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY12_RS14135 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVY12_RS14150 ENOG4105VG0 50S ribosomal protein l34 HVY12_RS14185 ENOG4108P6C Tryptophan transporter of low affinity HVY12_RS14200 ENOG4105E8Q phosphopantetheinyl transferase HVY12_RS14205 ENOG4108YYH Nadph-dependent fmn reductase HVY12_RS14210 ENOG4105C7N Xanthine uracil vitamin C permease HVY12_RS14215 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVY12_RS14220 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVY12_RS14225 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVY12_RS14230 ENOG4105E2Z phosphate ABC transporter (Permease HVY12_RS14235 ENOG4105C8U phosphate abc transporter HVY12_RS14240 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVY12_RS14245 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVY12_RS14295 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVY12_RS14310 ENOG4105QTB Flavodoxin HVY12_RS14315 ENOG4108VVK transcriptional Regulator, AsnC HVY12_RS14325 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HVY12_RS14345 ENOG4105C2J ABC transporter HVY12_RS14350 ENOG4105CNN ABC, transporter HVY12_RS14355 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY12_RS14360 ENOG4108RVA ribokinase HVY12_RS14365 ENOG4105ETE Transcriptional regulator (LacI family HVY12_RS14375 ENOG4107EJG GntR family transcriptional regulator HVY12_RS14415 ENOG4108WFC UPF0438 protein yifE HVY12_RS14420 ENOG4105C0P Mg chelatase subunit ChlI HVY12_RS14440 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVY12_RS14445 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVY12_RS14455 ENOG4105C7B Threonine dehydratase HVY12_RS14460 ENOG4105EMY transcriptional regulator HVY12_RS14470 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVY12_RS14475 ENOG4105C4R Atp-dependent dna helicase HVY12_RS14500 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVY12_RS14505 ENOG4105ESV Glycosyl transferase, family 4 HVY12_RS14510 ENOG4105SFE lipopolysaccharide biosynthesis protein HVY12_RS14515 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVY12_RS14520 ENOG4107QQG Dehydrogenase HVY12_RS14525 ENOG4108WJ1 acetyltransferase HVY12_RS14530 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVY12_RS14535 ENOG4105EGZ biosynthesis protein HVY12_RS14540 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HVY12_RS14580 ENOG4105C4X radical SAM domain protein HVY12_RS14585 ENOG4105ENH Sulfatase HVY12_RS14590 ENOG410601J HemY protein HVY12_RS14595 ENOG4105ECF c-methyltransferase HVY12_RS14600 ENOG41076E6 Uroporphyrinogen-III Synthase HVY12_RS14610 ENOG4107T0K Adenylate cyclase HVY12_RS14635 ENOG4105S7Z (LipO)protein HVY12_RS14645 ENOG4105CT0 Protein of unknown function, DUF484 HVY12_RS14655 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVY12_RS14660 ENOG4105C4R Atp-dependent dna helicase HVY12_RS14665 ENOG4108T58 Mg2 transport protein CorA HVY12_RS14670 ENOG4107QUT magnesium and cobalt transport protein CorA HVY12_RS14675 ENOG4105NRM Membrane HVY12_RS14680 ENOG4106WR8 Inner membrane protein YigG HVY12_RS14685 ENOG4105FR1 rard protein HVY12_RS14690 ENOG4108VUY thioesterase Superfamily protein HVY12_RS14695 ENOG4105HDD phospholipase HVY12_RS14700 ENOG4105C9U ATP-dependent DNA helicase RecQ HVY12_RS14705 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVY12_RS14710 ENOG410829K Lysine exporter protein (Lyse ygga) HVY12_RS14715 ENOG4108EUD Lysophospholipase HVY12_RS14720 ENOG4105DQF Hydrolase HVY12_RS14725 ENOG4105EMK carboxylate amino acid amine transporter HVY12_RS14730 ENOG4105DZ2 Transcriptional regulator HVY12_RS14740 ENOG4105F52 Transcriptional regulator HVY12_RS14745 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVY12_RS14755 ENOG4105C5B carbamate kinase HVY12_RS14760 ENOG4107REC cytoplasmic protein HVY12_RS14765 ENOG4107R1Q Membrane protein FdrA HVY12_RS14775 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HVY12_RS14780 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVY12_RS14785 ENOG4108I5U Uridine phosphorylase HVY12_RS14790 ENOG4105CGY Dna recombination protein HVY12_RS14800 ENOG4105JC1 sterol-binding domain protein HVY12_RS14810 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVY12_RS14815 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVY12_RS14820 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVY12_RS14830 ENOG4105MDZ Transcriptional activator rfaH HVY12_RS14835 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY12_RS14840 ENOG4108EX3 reductase HVY12_RS14860 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVY12_RS14865 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY12_RS14870 ENOG4108RR8 protoporphyrinogen oxidase HVY12_RS14895 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVY12_RS14900 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVY12_RS14905 ENOG4105PC1 Conserved Protein HVY12_RS14910 ENOG4105E27 serine threonine protein kinase HVY12_RS14915 ENOG4108Z33 Thiol disulfide Interchange Protein HVY12_RS14925 ENOG4106HNH Acyl-transferase HVY12_RS14930 ENOG4105C2M dna polymerase I HVY12_RS14950 ENOG4105D4P Coproporphyrinogen iii oxidase HVY12_RS14955 ENOG4106FIY HVY12_RS14960 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY12_RS14965 ENOG4105CUX Signal transduction histidine kinase HVY12_RS14970 ENOG4105C5F glutamine synthetase HVY12_RS14975 ENOG4105CI3 gtp-binding protein typa HVY12_RS14980 ENOG4108K85 Transcriptional regulator HVY12_RS14985 ENOG4108KHF Resistance protein HVY12_RS14990 ENOG4105R9B Major Facilitator HVY12_RS14995 ENOG4105E98 transcriptional regulator DeoR family HVY12_RS15000 ENOG4108MGF sugar kinase HVY12_RS15005 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY12_RS15010 ENOG4105D2M Aldolase HVY12_RS15015 ENOG4105CPQ Dehydrogenase HVY12_RS15025 ENOG4105CSH Transporter HVY12_RS15035 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVY12_RS15050 ENOG4105SUU thioesterase domain HVY12_RS15070 ENOG4108MG3 formate dehydrogenase HVY12_RS15075 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY12_RS15090 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HVY12_RS15100 ENOG4108V87 frv operon regulatory protein HVY12_RS15105 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY12_RS15110 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVY12_RS15115 ENOG4105H6Q decarboxylase HVY12_RS15120 ENOG4105CMG Carbohydrate kinase HVY12_RS15125 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVY12_RS15130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVY12_RS15135 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVY12_RS15140 ENOG4108M5W HVY12_RS15145 ENOG4108R66 Conserved Protein HVY12_RS15155 ENOG4105J4Q Transcriptional regulator HVY12_RS15160 ENOG4108XIB electron transport protein ysaA HVY12_RS15165 ENOG4105JKW Valine--pyruvate aminotransferase HVY12_RS15170 ENOG4107T9C Alpha amylase catalytic region HVY12_RS15175 ENOG4108UR8 BAX protein HVY12_RS15180 ENOG4105T16 Transcriptional regulator (AraC family) HVY12_RS15185 ENOG4108HWW ABC transporter HVY12_RS15195 ENOG4105DFW ABC transporter HVY12_RS15205 ENOG4105CMG Carbohydrate kinase HVY12_RS15210 ENOG410688U Inner membrane protein yiaB HVY12_RS15215 ENOG4108Z12 YiaAB two helix domain-containing protein HVY12_RS15220 ENOG4105MEV Acyl-transferase HVY12_RS15255 ENOG4105MVF Transcriptional regulator HVY12_RS15260 ENOG4106JH6 (LipO)protein HVY12_RS15270 ENOG4108ZG0 Ompa motb domain protein HVY12_RS15275 ENOG4107QY8 reductase HVY12_RS15280 ENOG4105HNP -acetyltransferase HVY12_RS15285 ENOG4108R3E Dna-3-methyladenine glycosylase i HVY12_RS15290 ENOG4105EAX Putative lipase HVY12_RS15295 ENOG4105FCD Major Facilitator HVY12_RS15300 ENOG4106EAR Fimbrial protein HVY12_RS15305 ENOG4108VCD Chaperone HVY12_RS15310 ENOG4105CW0 outer membrane usher protein HVY12_RS15315 ENOG4105MHR Fimbrial protein HVY12_RS15320 ENOG4106UCC Fimbrial protein HVY12_RS15325 ENOG4105DIJ Phosphoethanolamine transferase HVY12_RS15340 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY12_RS15345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY12_RS15350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY12_RS15355 ENOG4105C3U ABC transporter HVY12_RS15360 ENOG4108JQ7 (ABC) transporter HVY12_RS15365 ENOG4105C44 Serine transporter HVY12_RS15380 ENOG4105D1V cellulose synthase operon protein YhjU HVY12_RS15385 ENOG4105WQA Cellulose biosynthesis protein BcsF HVY12_RS15390 ENOG4105U74 cellulose biosynthesis protein BcsE HVY12_RS15395 ENOG410661M cytoplasmic protein HVY12_RS15405 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY12_RS15410 ENOG4107EEX Cellulose synthase regulator protein HVY12_RS15415 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVY12_RS15420 ENOG4105EJG cellulose synthase HVY12_RS15425 ENOG4105BZU Histidine kinase HVY12_RS15435 ENOG4105CS0 peptidase HVY12_RS15455 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVY12_RS15460 ENOG4105CMB EAL domain-containing protein HVY12_RS15465 ENOG41066T0 asmA family HVY12_RS15470 ENOG4105CSH Transporter HVY12_RS15475 ENOG4107H3J ribonuclease HVY12_RS15480 ENOG4105CBN LysR family transcriptional regulator HVY12_RS15485 ENOG4106S2D Transcriptional regulator HVY12_RS15495 ENOG4105CVK Glutamate decarboxylase HVY12_RS15500 ENOG4108NKV transcriptional regulator HVY12_RS15510 ENOG4105BZS acriflavin resistance protein HVY12_RS15515 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY12_RS15525 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVY12_RS15530 ENOG4108YK4 Acid-resistance membrane protein HVY12_RS15535 ENOG41060V2 Acid-resistance protein HVY12_RS15540 ENOG4105XXV Acid-resistance protein HVY12_RS15545 ENOG4105KT7 mgtC SapB transporter HVY12_RS15550 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HVY12_RS15555 ENOG4105EHG Permease protein HVY12_RS15565 ENOG41090JE Utilization Protein HVY12_RS15570 ENOG4105D4P Coproporphyrinogen iii oxidase HVY12_RS15575 ENOG4107R4I Periplasmic binding protein HVY12_RS15580 ENOG4107ENK receptor HVY12_RS15585 ENOG4106QJH hemin transport protein HVY12_RS15595 ENOG4105Y4Z Outer Membrane Lipoprotein HVY12_RS15600 ENOG4105K89 arsenate reductase HVY12_RS15605 ENOG4107R5R arsenical pump membrane protein HVY12_RS15610 ENOG4105KBH arsR family transcriptional regulator HVY12_RS15620 ENOG4105DC8 reductase HVY12_RS15625 ENOG4105D6S protein involved in catabolism of external DNA HVY12_RS15630 ENOG4105DGW oligopeptidase A HVY12_RS15640 ENOG4105DUX Transporter HVY12_RS15660 ENOG4105CJ3 phosphate transporter HVY12_RS15665 ENOG4105CBX hi0933 family HVY12_RS15670 ENOG4107UNS conserved inner membrane protein HVY12_RS15675 ENOG4105D0S secretion protein (HlyD HVY12_RS15680 ENOG4105CJ1 ABC, transporter HVY12_RS15685 ENOG4105CMI transporter HVY12_RS15695 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY12_RS15700 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY12_RS15705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY12_RS15710 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY12_RS15715 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVY12_RS15720 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVY12_RS15725 ENOG4105DSF transport protein HVY12_RS15730 ENOG4105F9N Major Facilitator Superfamily HVY12_RS15735 ENOG4108W1V Lipoprotein HVY12_RS15740 ENOG4105EX9 Membrane HVY12_RS15760 ENOG4107FS9 Membrane HVY12_RS15770 ENOG4105MG3 Membrane HVY12_RS15775 ENOG4106H78 methyltransferase HVY12_RS15780 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVY12_RS15785 ENOG4105CAK Cell division ATP-binding protein ftsE HVY12_RS15790 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVY12_RS15795 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY12_RS15800 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HVY12_RS15805 ENOG4108JQ1 Dehydrogenase HVY12_RS15830 ENOG4105CP9 extracellular ligand-binding receptor HVY12_RS15835 ENOG4105U59 -acetyltransferase HVY12_RS15840 ENOG4105CP9 extracellular ligand-binding receptor HVY12_RS15845 ENOG4105C32 Amino acid ABC transporter (Permease) HVY12_RS15850 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVY12_RS15855 ENOG4105C0Z ABC transporter HVY12_RS15860 ENOG4108IV0 ABC, transporter HVY12_RS15865 ENOG4105BZ7 extracellular solute-binding protein family 1 HVY12_RS15870 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVY12_RS15885 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVY12_RS15890 ENOG4105WC8 Conserved Protein HVY12_RS15895 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVY12_RS15900 ENOG4105WCN acetyltransferase HVY12_RS15905 ENOG4105D9R oxidoreductase HVY12_RS15910 ENOG4105C2I pirin domain protein HVY12_RS15915 ENOG4105DIQ Transcriptional regulator HVY12_RS15920 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVY12_RS15925 ENOG4105C6Z Gluconate HVY12_RS15930 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVY12_RS15935 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY12_RS15960 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY12_RS15970 ENOG4108AF8 Chaperone HVY12_RS15975 ENOG4105CW0 outer membrane usher protein HVY12_RS15990 ENOG4106PH7 chaperone HVY12_RS15995 ENOG4105MHR Fimbrial protein HVY12_RS16015 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVY12_RS16030 ENOG4105E98 transcriptional regulator DeoR family HVY12_RS16035 ENOG4105CYB regulatoR HVY12_RS16040 ENOG4105E0Y RtcB Protein HVY12_RS16055 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY12_RS16060 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVY12_RS16065 ENOG4105C6Z Gluconate HVY12_RS16075 ENOG4105MJ2 Competence protein HVY12_RS16080 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HVY12_RS16095 ENOG4105DNE Transposase HVY12_RS16105 ENOG4105CE1 Ferrous iron transport protein b HVY12_RS16110 ENOG4105XFK Ferrous iron transport protein A HVY12_RS16115 ENOG4105BZM domain protein HVY12_RS16120 ENOG4108RRZ Transcription elongation factor GreB HVY12_RS16130 ENOG4105E0F Histidine kinase HVY12_RS16145 ENOG4108MAJ Membrane HVY12_RS16150 ENOG4105D70 Integrase catalytic subunit HVY12_RS16155 ENOG4105F5W AtP-binding protein HVY12_RS16165 ENOG4105VEJ Heat shock protein HVY12_RS16170 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVY12_RS16175 ENOG4105DQY intracellular growth attenuator HVY12_RS16180 ENOG4107RK2 ADP-ribose diphosphatase NudE HVY12_RS16185 ENOG4108JQC penicillin-binding protein 1A HVY12_RS16190 ENOG4108U1Q Pilus assembly protein HVY12_RS16195 ENOG41065NF Fimbrial assembly family protein HVY12_RS16200 ENOG4105XPX DNA utilization protein HofO HVY12_RS16205 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVY12_RS16210 ENOG4105E4G Type IV pilus HVY12_RS16225 ENOG4105EGB membrane protein DamX HVY12_RS16230 ENOG4105DFE Dna adenine methylase HVY12_RS16235 ENOG4105DJV ribulose-phosphate 3-epimerase HVY12_RS16240 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVY12_RS16245 ENOG4105C31 Tryptophanyl-tRNA synthetase HVY12_RS16250 ENOG4108M21 HVY12_RS16255 ENOG4105RMW regulation of transcription, DNA-dependent HVY12_RS16260 ENOG4108626 Racemase HVY12_RS16265 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVY12_RS16270 ENOG41080QX K07048 phosphotriesterase-related protein HVY12_RS16275 ENOG4105MUZ Protein of unknown function DUF2620 HVY12_RS16280 ENOG4106M0N transport system permease protein HVY12_RS16285 ENOG4106PKC pyridoxal phosphate binding HVY12_RS16290 ENOG4105VYH HVY12_RS16295 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HVY12_RS16300 ENOG4107V9H nitrite transporter HVY12_RS16305 ENOG4105WZK nitrite reductase NADPH small subunit HVY12_RS16310 ENOG4107QZF nitrite reductase NADPH large subunit HVY12_RS16320 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY12_RS16330 ENOG4105MZU cell filamentation protein HVY12_RS16335 ENOG4105DDQ anthranilate synthase HVY12_RS16340 ENOG4105C8Y Acetylornithine aminotransferase HVY12_RS16345 ENOG410613R integral membrane protein, YccS YhfK family HVY12_RS16355 ENOG4108UKZ OsmC family HVY12_RS16360 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVY12_RS16370 ENOG4105DNZ Alpha Beta Hydrolase HVY12_RS16375 ENOG4105C5H ABC transporter HVY12_RS16380 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HVY12_RS16385 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVY12_RS16390 ENOG4105VKU nucleicacid-binding protein HVY12_RS16395 ENOG4108YZY peptidylprolyl cis-trans isomerase HVY12_RS16405 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY12_RS16410 ENOG4105WWK YheO domain protein HVY12_RS16420 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVY12_RS16450 ENOG4105W53 bacterioferritin-associated ferredoxin HVY12_RS16455 ENOG4108UQY Iron-storage protein HVY12_RS16480 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVY12_RS16510 ENOG41083MP 50s ribosomal protein l29 HVY12_RS16525 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVY12_RS16570 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVY12_RS16575 ENOG41067V7 50S ribosomal protein L36 HVY12_RS16600 ENOG4108ZT0 50S ribosomal protein l17 HVY12_RS16605 ENOG4105VTS DnaJ-like, subfamily C HVY12_RS16610 ENOG4105W1Y Transcriptional regulator HVY12_RS16615 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVY12_RS16625 ENOG4105C1A potassium transporter peripheral membrane HVY12_RS16645 ENOG4105C79 DNA protecting protein DprA HVY12_RS16655 ENOG4108WI1 Dna topoisomerase HVY12_RS16670 ENOG4105SG3 Protein of unknown function (DUF1488) HVY12_RS16675 ENOG4108Z0R Transferase HVY12_RS16715 ENOG4105CDA abc transporter atp-binding protein HVY12_RS16720 ENOG4105DRP amino acid AbC transporter HVY12_RS16725 ENOG4105EZ7 amino acid ABC transporter HVY12_RS16735 ENOG4105XCM membrane LIPOPROTEIN HVY12_RS16740 ENOG4105BZS acriflavin resistance protein HVY12_RS16745 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY12_RS16750 ENOG4108XG4 DNA-binding transcriptional regulator HVY12_RS16755 ENOG41061ME transport protein HVY12_RS16760 ENOG4105CEC DNA methylase N-4 N-6 HVY12_RS16770 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY12_RS16780 ENOG4108IA2 Sodium pantothenate symporter HVY12_RS16785 ENOG4105RG0 Membrane HVY12_RS16790 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVY12_RS16795 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVY12_RS16810 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVY12_RS16815 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVY12_RS16825 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVY12_RS16830 ENOG4105VQ7 Rod shape-determining protein MreD HVY12_RS16840 ENOG4105C03 ribonuclease HVY12_RS16845 ENOG4105QD6 exported protein HVY12_RS16850 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVY12_RS16860 ENOG4105D70 Integrase catalytic subunit HVY12_RS16865 ENOG4105F5W AtP-binding protein HVY12_RS16875 ENOG4105ZQC membrane protein AaeX HVY12_RS16890 ENOG4105UNR (Barnase) inhibitor HVY12_RS16895 ENOG4105RID UPF0379 protein yhcN HVY12_RS16910 ENOG4105C0H protease HVY12_RS16915 ENOG4105C0H protease HVY12_RS16920 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVY12_RS16925 ENOG4105D6Z AFG1 family ATPase HVY12_RS16930 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HVY12_RS16940 ENOG4107MKT Stringent starvation protein a HVY12_RS16945 ENOG4105KB2 stringent starvation protein b HVY12_RS16960 ENOG4105JHE Major Facilitator Superfamily HVY12_RS16975 ENOG4108R66 Conserved Protein HVY12_RS16985 ENOG4106RDH Protein of unknown function (DUF2544) HVY12_RS16990 ENOG4105US4 fimbrial-like protein yfcP HVY12_RS16995 ENOG4105UGQ Fimbrial HVY12_RS17000 ENOG4105NEV Fimbrial HVY12_RS17005 ENOG4108FZ9 Chaperone HVY12_RS17010 ENOG4106PG1 outer membrane usher protein HVY12_RS17015 ENOG4105HMV Fimbrial protein HVY12_RS17020 ENOG4105BZ8 glutamate synthase HVY12_RS17025 ENOG4105CBC glutamate synthase HVY12_RS17030 ENOG4105N5T Radical SAM Protein HVY12_RS17035 ENOG4105BZU Histidine kinase HVY12_RS17040 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVY12_RS17050 ENOG4105F5W AtP-binding protein HVY12_RS17055 ENOG4105D70 Integrase catalytic subunit HVY12_RS17065 ENOG41090EK ompa motb domain protein HVY12_RS17090 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVY12_RS17095 ENOG4106KVJ cytochrome C assembly protein HVY12_RS17100 ENOG4108JU6 CBS domain protein HVY12_RS17115 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVY12_RS17120 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY12_RS17130 ENOG4108Z1B Cyclase dehydrase HVY12_RS17150 ENOG4105D5U fad dependent oxidoreductase HVY12_RS17155 ENOG4105C26 Dehydrogenase HVY12_RS17160 ENOG4108JPW Aminotransferase HVY12_RS17165 ENOG4105C85 amino acid HVY12_RS17170 ENOG4108PVQ transcriptional regulator HVY12_RS17175 ENOG4109066 lysm domain bon superfamily protein HVY12_RS17180 ENOG4105VPI YqaE family transport protein HVY12_RS17185 ENOG41080HT Transcriptional regulator, arsr family HVY12_RS17190 ENOG4108V62 Rhodanese domain protein HVY12_RS17195 ENOG4108X73 DNA- binding protein HVY12_RS17200 ENOG4108RNS Exports L-alanine (By similarity) HVY12_RS17205 ENOG4108WMJ Protein of unknown function (DUF2002) HVY12_RS17210 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVY12_RS17220 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY12_RS17225 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVY12_RS17235 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY12_RS17240 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY12_RS17245 ENOG4108IJ7 Glycine betaine HVY12_RS17250 ENOG4108HQS Glycine betaine HVY12_RS17255 ENOG4105GIJ Glycine betaine HVY12_RS17265 ENOG4108UMN azlc family HVY12_RS17270 ENOG4105ZED uncharacterized protein ygaH HVY12_RS17275 ENOG4105NTK Transcriptional repressor Mpra HVY12_RS17280 ENOG4105CW7 secretion protein, HlyD family HVY12_RS17285 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY12_RS17305 ENOG4105W39 Membrane HVY12_RS17310 ENOG4107VXZ Hydrolase HVY12_RS17340 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVY12_RS17360 ENOG4107TH8 cina domain protein HVY12_RS17370 ENOG4105CVE Lytic murein transglycosylase HVY12_RS17375 ENOG410787A Pts system, glucitol sorbitol-specific HVY12_RS17380 ENOG4105DZY Pts system, glucitol sorbitol-specific HVY12_RS17385 ENOG4105VI0 Pts system, glucitol sorbitol-specific HVY12_RS17390 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HVY12_RS17395 ENOG4105J92 DNA-binding transcriptional activator GutM HVY12_RS17400 ENOG410804X Transcriptional regulator HVY12_RS17405 ENOG4105C2X Arabinose 5-phosphate isomerase HVY12_RS17425 ENOG4105C8H hydrogenase maturation protein Hypf HVY12_RS17430 ENOG4108RC0 Electron transport protein HVY12_RS17445 ENOG4108MG9 hydrogenase 3 maturation protease HVY12_RS17450 ENOG4105I6X formate hydrogenlyase maturation HVY12_RS17455 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY12_RS17460 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVY12_RS17465 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY12_RS17470 ENOG4107TDF Formate hydrogenlyase subunit 4 HVY12_RS17475 ENOG4107R30 NADH dehydrogenase HVY12_RS17480 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY12_RS17485 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVY12_RS17490 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVY12_RS17495 ENOG4107RSS Hydrogenase accessory protein HypB HVY12_RS17500 ENOG41083WG hydrogenase assembly chaperone HVY12_RS17505 ENOG4105CQS hydrogenase expression formation protein HypD HVY12_RS17510 ENOG4105C45 hydrogenase expression formation protein (HypE) HVY12_RS17515 ENOG4108JUA Transcriptional regulator HVY12_RS17525 ENOG4105VXR cytoplasmic protein HVY12_RS17545 ENOG4105MEW serine threonine protein phosphatase HVY12_RS17550 ENOG4105MVE transcriptional regulator HVY12_RS17560 ENOG4105G63 Type III effector Hrp-dependent HVY12_RS17565 ENOG4105FB2 class II Aldolase HVY12_RS17570 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVY12_RS17575 ENOG4105C6Z Gluconate HVY12_RS17585 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY12_RS17590 ENOG4108K5P (LipO)protein HVY12_RS17625 ENOG4105N0Z inner membrane protein ygbE HVY12_RS17645 ENOG4108MXK alkaline phosphatase isozyme conversion HVY12_RS17650 ENOG4107635 Hok Gef family protein HVY12_RS17660 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HVY12_RS17670 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVY12_RS17675 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVY12_RS17680 ENOG4105WQV ferredoxin-like protein HVY12_RS17685 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVY12_RS17690 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVY12_RS17695 ENOG4106IKH Electron transfer flavoprotein HVY12_RS17700 ENOG4105C54 Major Facilitator superfamily HVY12_RS17705 ENOG4107R3A FAD linked oxidase domain protein HVY12_RS17710 ENOG4105CHR reductase HVY12_RS17715 ENOG4108ITV Inner membrane protein yqcE HVY12_RS17720 ENOG4108CWB sugar kinase ygcE HVY12_RS17725 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVY12_RS17735 ENOG4105HA9 of methanol dehydrogenase type HVY12_RS17740 ENOG4105HA9 of methanol dehydrogenase type HVY12_RS17755 ENOG4105DXN mazG family HVY12_RS17760 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY12_RS17765 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVY12_RS17770 ENOG4105BZU Histidine kinase HVY12_RS17775 ENOG4105QDK Flavodoxin HVY12_RS17780 ENOG4105DR9 pseudouridine synthase HVY12_RS17785 ENOG4105WP7 tRNA pseudouridine synthase C HVY12_RS17800 ENOG4105EWT decarboxylase family HVY12_RS17805 ENOG4105C44 Serine transporter HVY12_RS17810 ENOG4105EJQ L-serine dehydratase HVY12_RS17820 ENOG4105C0A alcohol dehydrogenase HVY12_RS17825 ENOG4107W7X Aldolase HVY12_RS17835 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HVY12_RS17845 ENOG4105CNN ABC, transporter HVY12_RS17850 ENOG4105C2J ABC transporter HVY12_RS17860 ENOG4105CMG Carbohydrate kinase HVY12_RS17870 ENOG4107EDW L-fucose operon activator HVY12_RS17880 ENOG4105M08 Membrane HVY12_RS17885 ENOG4105ETT transcriptional Regulator, LysR family HVY12_RS17890 ENOG4105M5B (LipO)protein HVY12_RS17895 ENOG4105C9B Cysteine desulfurase HVY12_RS17900 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVY12_RS17905 ENOG4105CUZ uba thif-type nad fad binding protein HVY12_RS17910 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVY12_RS17930 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY12_RS17935 ENOG4108EKC n-acetylglutamate synthase HVY12_RS17940 ENOG4107QYX exodeoxyribonuclease v alpha HVY12_RS17945 ENOG4107QKA exodeoxyribonuclease V beta HVY12_RS17950 ENOG4107QXK peptidase HVY12_RS17955 ENOG4105DSY exodeoxyribonuclease V, gamma HVY12_RS17960 ENOG4105RVB Prepilin peptidase dependent protein c HVY12_RS17965 ENOG4105SEN Protein of unknown function (DUF2509) HVY12_RS17970 ENOG4105JCS prepilin peptidase dependent protein HVY12_RS17975 ENOG4105IPU prepilin peptidase dependent protein A HVY12_RS17990 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVY12_RS18005 ENOG4105EE5 Membrane protein terC HVY12_RS18010 ENOG4105SUV lipoprotein YgdR HVY12_RS18015 ENOG4105CPC Aldo Keto reductase HVY12_RS18035 ENOG41060NJ transcriptional regulator HVY12_RS18045 ENOG4105RQF LysR family Transcriptional regulator HVY12_RS18055 ENOG4107QNK )-transporter HVY12_RS18060 ENOG4105CHR reductase HVY12_RS18070 ENOG4105CHU acetyl-coa acetyltransferase HVY12_RS18075 ENOG4108MHD transport protein HVY12_RS18080 ENOG4105ISV protein with bipartite regulator domain HVY12_RS18085 ENOG4108TC1 Transcriptional regulator HVY12_RS18090 ENOG4105FV3 HVY12_RS18095 ENOG4108YAB Invasion protein HVY12_RS18130 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HVY12_RS18180 ENOG4105DFP Integrase HVY12_RS18190 ENOG4108K5P (LipO)protein HVY12_RS18195 ENOG4105C7W Xanthine dehydrogenase HVY12_RS18200 ENOG4108HR6 Dehydrogenase HVY12_RS18205 ENOG4108UTP (2Fe-2S)-binding domain protein HVY12_RS18210 ENOG4108JUB Transcriptional regulator HVY12_RS18215 ENOG4105IW6 Carbamoyltransferase HVY12_RS18220 ENOG4107RCH Diaminopropionate ammonia-lyase HVY12_RS18225 ENOG4107S4Y M20 DapE family protein YgeY HVY12_RS18235 ENOG4105C5B carbamate kinase HVY12_RS18240 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HVY12_RS18245 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HVY12_RS18250 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HVY12_RS18255 ENOG4105BZ8 glutamate synthase HVY12_RS18260 ENOG4107UUR Chlorohydrolase aminohydrolase HVY12_RS18265 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HVY12_RS18270 ENOG4105C7W Xanthine dehydrogenase HVY12_RS18275 ENOG4105C2W permease HVY12_RS18280 ENOG4107QUY Guanine deaminase HVY12_RS18285 ENOG4105C7N Xanthine uracil vitamin C permease HVY12_RS18290 ENOG4108R8B oxidoreductase Fe-S subunit HVY12_RS18295 ENOG4105BZ8 glutamate synthase HVY12_RS18300 ENOG4105C2W permease HVY12_RS18310 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HVY12_RS18315 ENOG4105CRK lysyL-tRNA synthetase HVY12_RS18325 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVY12_RS18330 ENOG4105T95 Thiol disulfide interChange protein HVY12_RS18335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY12_RS18340 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVY12_RS18345 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVY12_RS18350 ENOG4105Y75 tpr repeat protein HVY12_RS18360 ENOG4108UT2 hemolysin iii HVY12_RS18370 ENOG4105CS2 ec 3.2.1.21 HVY12_RS18385 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HVY12_RS18395 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY12_RS18400 ENOG4105D0A hydroxylase HVY12_RS18405 ENOG4107RAQ aminopeptidase HVY12_RS18425 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVY12_RS18430 ENOG4105C0A alcohol dehydrogenase HVY12_RS18435 ENOG4105KRI phosphocarrier protein (HPr HVY12_RS18450 ENOG4105DT3 PTS system, galactitol-specific IIc component HVY12_RS18455 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVY12_RS18470 ENOG4108JQ1 Dehydrogenase HVY12_RS18485 ENOG4105D5P Methylmalonyl-coA mutase HVY12_RS18490 ENOG4105DJT lAO AO transport system ATPase HVY12_RS18495 ENOG4108M7F enoyl-CoA hydratase isomerase HVY12_RS18500 ENOG4105CYC Transferase HVY12_RS18505 ENOG4105DEQ transcriptional regulator HVY12_RS18510 ENOG4105MPN Membrane HVY12_RS18515 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVY12_RS18530 ENOG4105D64 Mechanosensitive ion channel HVY12_RS18535 ENOG4105D2N Aldolase HVY12_RS18565 ENOG4108JJB ABC transporter HVY12_RS18575 ENOG4107Z1W Fructose transport system kinase HVY12_RS18580 ENOG4108R4K DNA-binding, transcriptional regulator HVY12_RS18585 ENOG4108Q8A Fructose-1,6-bisphosphatase HVY12_RS18590 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY12_RS18595 ENOG4105CTS PTS system mannitol-specific HVY12_RS18600 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVY12_RS18605 ENOG4105EPW hflc protein HVY12_RS18610 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY12_RS18615 ENOG4108K0D peptidase, M48 HVY12_RS18630 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVY12_RS18650 ENOG4107QNK )-transporter HVY12_RS18660 ENOG4105RWS endonuclease I HVY12_RS18665 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVY12_RS18670 ENOG4105D7Z glutathione synthase HVY12_RS18685 ENOG4105CZX twitching motility protein HVY12_RS18690 ENOG4105DFA alanine racemase domain protein HVY12_RS18695 ENOG4108VIA integral membrane protein HVY12_RS18705 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVY12_RS18710 ENOG4105CSA Coproporphyrinogen iii oxidase HVY12_RS18715 ENOG4106MH3 alpha helix chain HVY12_RS18720 ENOG4105HDK L-asparaginase HVY12_RS18725 ENOG4105K33 Periplasmic Protein HVY12_RS18730 ENOG41090ED Protein with unknown function (DUF469) HVY12_RS18740 ENOG4105CEN a g-specific adenine glycosylase HVY12_RS18755 ENOG4105EAA nucleoside HVY12_RS18760 ENOG4105CXN decarboxylase HVY12_RS18765 ENOG4108UQV Membrane HVY12_RS18775 ENOG4105DFP Integrase HVY12_RS18790 ENOG4105D70 Integrase catalytic subunit HVY12_RS18795 ENOG4105F5W AtP-binding protein HVY12_RS18835 ENOG4105T40 surface antigen msp4 family protein HVY12_RS18845 ENOG4105WBN Transcriptional regulator (LacI family HVY12_RS18870 ENOG4105F5W AtP-binding protein HVY12_RS18875 ENOG4105D70 Integrase catalytic subunit HVY12_RS18925 ENOG4105GTN ParB Domain Protein Nuclease HVY12_RS18930 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVY12_RS18960 ENOG4105UPP uncharacterized protein ydcA HVY12_RS19025 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY12_RS19035 ENOG4108ZG0 Ompa motb domain protein HVY12_RS19095 ENOG4105X5Z General secretion pathway protein I HVY12_RS19105 ENOG4108VAU general secretion pathway protein G HVY12_RS19110 ENOG4105D7Q type ii secretion system HVY12_RS19115 ENOG4107QHF type ii secretion system protein e HVY12_RS19150 ENOG4105BZU Histidine kinase HVY12_RS19265 ENOG4105TS0 gtp-binding protein HVY12_RS19270 ENOG4108KZE transcriptional regulator HVY12_RS19290 ENOG4106H6R UPF0380 protein HVY12_RS19295 ENOG4106549 Antirestriction protein HVY12_RS19300 ENOG4108YGG dna repair protein HVY12_RS19315 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVY12_RS19340 ENOG4105X54 addiction module antidote protein HVY12_RS19350 ENOG4105D70 Integrase catalytic subunit HVY12_RS19355 ENOG4105F5W AtP-binding protein HVY12_RS19360 ENOG4105U1E general secretion pathway protein M HVY12_RS19380 ENOG4105X5Z General secretion pathway protein I HVY12_RS19390 ENOG4108VAU general secretion pathway protein G HVY12_RS19395 ENOG4105D7Q type ii secretion system HVY12_RS19400 ENOG4107QHF type ii secretion system protein e HVY12_RS19410 ENOG4108XKW General secretion pathway protein C HVY12_RS19415 ENOG410765S (LipO)protein HVY12_RS19420 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVY12_RS19425 ENOG4105F88 accessory colonization factor AcfD HVY12_RS19430 ENOG4105DAA L-lactate HVY12_RS19435 ENOG4107QP3 malate synthase g HVY12_RS19440 ENOG4108ZJF Glcg protein HVY12_RS19445 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY12_RS19450 ENOG4105EU8 FAD linked oxidase domain protein HVY12_RS19455 ENOG4105CQB FAD linked oxidase domain protein HVY12_RS19460 ENOG4108KWP DNA-binding transcriptional regulator GlcC HVY12_RS19470 ENOG4107RCI amp-dependent synthetase and ligase HVY12_RS19475 ENOG4108SMP Nad-dependent epimerase dehydratase HVY12_RS19480 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVY12_RS19485 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVY12_RS19495 ENOG4108M8S permease YjgP YjgQ family protein HVY12_RS19500 ENOG4108UUE Transcriptional regulator HVY12_RS19510 ENOG4108S55 polysaccharide biosynthesis protein HVY12_RS19515 ENOG4106FPV ATP-binding protein YghR HVY12_RS19520 ENOG4108NDC ATP-binding protein yghS HVY12_RS19525 ENOG4108GH0 ATP-binding protein yghT HVY12_RS19530 ENOG4105CJ3 phosphate transporter HVY12_RS19535 ENOG4106032 Glutathionylspermidine synthase HVY12_RS19540 ENOG4105CYM Glutathione S-transferase HVY12_RS19545 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVY12_RS19555 ENOG4108WGS hydrogenase 2-specific chaperone HVY12_RS19560 ENOG4108USZ hydrogenase HVY12_RS19565 ENOG4105DPX Hydrogenase, large subunit HVY12_RS19570 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVY12_RS19575 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY12_RS19580 ENOG4105E3S small subunit HVY12_RS19585 ENOG410900S Protein of unknown function (DUF2623) HVY12_RS19595 ENOG4105CPC Aldo Keto reductase HVY12_RS19610 ENOG4108ZZF transport protein (ExbD) HVY12_RS19615 ENOG4105CWK Biopolymer transport protein, ExbB HVY12_RS19620 ENOG4105C28 cystathionine HVY12_RS19625 ENOG4108K81 inner membrane protein YghB HVY12_RS19630 ENOG4105CF7 AraC family transcriptional regulator HVY12_RS19635 ENOG4108I6A alcohol dehydrogenase HVY12_RS19640 ENOG4105CV8 reductase HVY12_RS19645 ENOG4105ZKC Conserved Protein HVY12_RS19655 ENOG4105CCT upf0313 protein HVY12_RS19660 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVY12_RS19665 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVY12_RS19670 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY12_RS19675 ENOG4108J59 Extracellular solute-binding protein, family 5 HVY12_RS19680 ENOG4105F4I Transcriptional regulator HVY12_RS19685 ENOG4105H4F exported protein HVY12_RS19690 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY12_RS19695 ENOG4105DHQ Histidine kinase HVY12_RS19700 ENOG4105NF4 modulator of drug activity HVY12_RS19705 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVY12_RS19710 ENOG4106KNT transcriptional regulator HVY12_RS19720 ENOG4105EHG Permease protein HVY12_RS19725 ENOG4105DQ5 transport system permease protein HVY12_RS19730 ENOG4105E0A ABC, transporter HVY12_RS19740 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY12_RS19745 ENOG4105IPS esterase HVY12_RS19750 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVY12_RS19755 ENOG4108SX3 cytoplasmic protein HVY12_RS19760 ENOG41087AY ADP-Ribose pyrophosphatase HVY12_RS19765 ENOG4105DFG type I secretion outer membrane protein HVY12_RS19775 ENOG4106032 Glutathionylspermidine synthase HVY12_RS19780 ENOG4108MR7 Arylsulfotransferase HVY12_RS19785 ENOG4108N92 Thiol disulfide Interchange Protein HVY12_RS19795 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVY12_RS19810 ENOG4105W0Z cytoplasmic protein HVY12_RS19820 ENOG4105PV3 Inner membrane protein yqiJ HVY12_RS19825 ENOG4107S78 Band 7 protein HVY12_RS19845 ENOG4105I7R Adenylate cyclase HVY12_RS19850 ENOG4106MWK domain protein HVY12_RS19865 ENOG4107ZVW dihydroneopterin aldolase HVY12_RS19885 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVY12_RS19890 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY12_RS19905 ENOG4105Q26 Siderophore-interacting protein HVY12_RS19910 ENOG4105NTW Transcriptional regulator HVY12_RS19915 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVY12_RS19925 ENOG4108Y51 tRNA-binding protein HVY12_RS19930 ENOG4105CQ4 Transcriptional regulator HVY12_RS19935 ENOG4105CNT hydrolase family 2 HVY12_RS19940 ENOG4105FK9 beta-D-galactosidase beta subunit HVY12_RS19945 ENOG4105E5D amino acid HVY12_RS19950 ENOG4107W6W Conserved Protein HVY12_RS19955 ENOG4107WCA isomerase HVY12_RS19960 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY12_RS19970 ENOG4108VKG metal-dependent hydrolase HVY12_RS19975 ENOG4108UB4 uncharacterized protein ygjQ HVY12_RS19980 ENOG4105EE0 oxidoreductase HVY12_RS19985 ENOG4105DU1 integral membrane protein, terc HVY12_RS19990 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVY12_RS19995 ENOG4105P66 Membrane HVY12_RS20000 ENOG4105CTX dehydratase HVY12_RS20010 ENOG4105DPW Major facilitator superfamily MFS_1 HVY12_RS20015 ENOG4107YCY Transcriptional regulator HVY12_RS20020 ENOG4106W5V Membrane HVY12_RS20025 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HVY12_RS20030 ENOG4105WAY exported protein HVY12_RS20035 ENOG4105NE1 Conserved Protein HVY12_RS20040 ENOG41090KG Inner membrane protein YqjE HVY12_RS20045 ENOG4105YJD HVY12_RS20050 ENOG4108VBZ doxx family HVY12_RS20055 ENOG4105CHF Glutathione S-transferase HVY12_RS20060 ENOG4105KAF membrAne HVY12_RS20065 ENOG4105CWB LysR family transcriptional Regulator HVY12_RS20070 ENOG4108CNN domain protein HVY12_RS20075 ENOG4106D80 Uncharacterized protein YhaL HVY12_RS20085 ENOG4105C44 Serine transporter HVY12_RS20090 ENOG4105EJQ L-serine dehydratase HVY12_RS20095 ENOG4105KME endoribonuclease L-psp HVY12_RS20100 ENOG4105C6N Formate acetyltransferase HVY12_RS20115 ENOG4105C7B Threonine dehydratase HVY12_RS20120 ENOG410811B TRANSCRIPTIONal HVY12_RS20130 ENOG4105BZW Glycerate kinase HVY12_RS20135 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY12_RS20140 ENOG4105CNV Aldolase HVY12_RS20145 ENOG4105DJB Major Facilitator Superfamily HVY12_RS20150 ENOG4105CTX dehydratase HVY12_RS20155 ENOG4105E98 transcriptional regulator DeoR family HVY12_RS20165 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVY12_RS20175 ENOG4105F3R pts system mannose fructose sorbose family iid HVY12_RS20180 ENOG4108YTN IIa component HVY12_RS20190 ENOG4105E70 isomerase HVY12_RS20200 ENOG4108UZY PTS System HVY12_RS20205 ENOG4105ETZ PTS System HVY12_RS20210 ENOG4105F3R pts system mannose fructose sorbose family iid HVY12_RS20215 ENOG4106HBN Galactosamine-6-phosphate isomerase HVY12_RS20220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVY12_RS20225 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HVY12_RS20240 ENOG4105W4M Transport-associated protein HVY12_RS20245 ENOG4107S21 permease HVY12_RS20250 ENOG4105K4T epimerase HVY12_RS20265 ENOG4108YYD acetyltransferase HVY12_RS20285 ENOG4105DEN Luciferase family HVY12_RS20290 ENOG4105CIC tryptophan-specific transport protein HVY12_RS20295 ENOG4105C1J atp-dependent rna helicase HVY12_RS20335 ENOG4105CHV Transcription elongation factor NusA HVY12_RS20365 ENOG4105NTZ Preprotein translocase subunit SecG HVY12_RS20375 ENOG4105EEI dihydropteroate synthase HVY12_RS20380 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVY12_RS20390 ENOG4105HBR Rna-binding protein HVY12_RS20395 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVY12_RS20400 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVY12_RS20410 ENOG4105QYV Membrane HVY12_RS20425 ENOG4105EAH synthase HVY12_RS20430 ENOG4105HVQ Regulatory factor of maltose metabolism HVY12_RS20440 ENOG4105VFK BolA family HVY12_RS20445 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVY12_RS20450 ENOG4105E3I toluene tolerance HVY12_RS20455 ENOG4107PE3 Mammalian cell entry related domain protein HVY12_RS20460 ENOG4105CY3 ABC transporter, permease HVY12_RS20465 ENOG4105DHJ ABC, transporter HVY12_RS20470 ENOG4105FEU K -dependent Na -Ca exchanger HVY12_RS20475 ENOG4105C2X Arabinose 5-phosphate isomerase HVY12_RS20485 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVY12_RS20490 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVY12_RS20495 ENOG4108IUZ ABC transporter HVY12_RS20500 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY12_RS20505 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVY12_RS20510 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVY12_RS20520 ENOG41080Z8 PHOSPHOCARRIER protein HVY12_RS20525 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVY12_RS20535 ENOG4105D70 Integrase catalytic subunit HVY12_RS20540 ENOG4105F5W AtP-binding protein HVY12_RS20550 ENOG4108WS1 HVY12_RS20555 ENOG4105QP9 Protein of unknown function (DUF2799) HVY12_RS20560 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY12_RS20565 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVY12_RS20570 ENOG4105CQC Prephenate dehydratase HVY12_RS20580 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVY12_RS20585 ENOG4105VNT transposase (IS4 family) protein HVY12_RS20590 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVY12_RS20595 ENOG4105C34 Pseudouridine synthase HVY12_RS20600 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVY12_RS20605 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY12_RS20630 ENOG4105CSH Transporter HVY12_RS20635 ENOG4105T42 (LipO)protein HVY12_RS20640 ENOG4105JIM Phosphatidylserine synthase HVY12_RS20645 ENOG4105CD5 CoA-binding domain protein HVY12_RS20650 ENOG4106IUH DTW domain containing protein HVY12_RS20655 ENOG4105K63 Thioredoxin HVY12_RS20660 ENOG4105EIB trna rrna methyltransferase HVY12_RS20675 ENOG4105C1J atp-dependent rna helicase HVY12_RS20685 ENOG4108IYU L-aspartate oxidase HVY12_RS20695 ENOG4105EMN RNA polymerase sigma factor HVY12_RS20700 ENOG41069PW sigma-e factor negative regulatory protein HVY12_RS20705 ENOG4105VQK sigma E regulatory protein, MucB RseB HVY12_RS20710 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVY12_RS20720 ENOG4105C3F Signal peptidase i HVY12_RS20740 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVY12_RS20750 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVY12_RS20755 ENOG4106G6Q Transcriptional regulator HVY12_RS20760 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVY12_RS20765 ENOG4108Z6B deaminase HVY12_RS20775 ENOG4108ETH Formylglycinamide ribotide synthetase HVY12_RS20780 ENOG4107WP9 Histidine kinase HVY12_RS20785 ENOG4108SKK alpha helix protein HVY12_RS20790 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY12_RS20800 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY12_RS20810 ENOG4108NZE NAGC-like transcriptional regulator HVY12_RS20815 ENOG4107HQ7 repeat protein HVY12_RS20820 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HVY12_RS20825 ENOG4108F37 ATP-binding component of a transport system HVY12_RS20830 ENOG4105CNN ABC, transporter HVY12_RS20835 ENOG4105CPQ Dehydrogenase HVY12_RS20840 ENOG4108ZKT aldose 1-epimerase HVY12_RS20845 ENOG4108SB3 DoxX Family HVY12_RS20850 ENOG4105D8G Major Facilitator superfamily HVY12_RS20855 ENOG4108MN2 Stationary phase inducible protein CsiE HVY12_RS20860 ENOG4107XM9 (LipO)protein HVY12_RS20865 ENOG4105ECY inositol monophosphatase HVY12_RS20885 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVY12_RS20905 ENOG4108ZIT Ferredoxin, 2FE-2S HVY12_RS20910 ENOG4105WVQ Fe-S assembly protein IscX HVY12_RS20920 ENOG4105YYA enhanced serine sensitivity protein SseB HVY12_RS20925 ENOG4105KHC sulfurtransferase HVY12_RS20930 ENOG4105DN3 alpha-2-macroglobulin domain protein HVY12_RS20935 ENOG4108JQB penicillin-binding protein 1C HVY12_RS20965 ENOG4105N21 Membrane HVY12_RS20980 ENOG4105VPD cellular component movement HVY12_RS20990 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVY12_RS21000 ENOG41066DY Membrane HVY12_RS21005 ENOG4108ZMA Outer membrane lipoprotein HVY12_RS21010 ENOG41062G3 Protein of unknown function (DUF2633) HVY12_RS21020 ENOG4105BZU Histidine kinase HVY12_RS21025 ENOG4105C9X ppx gppa phosphatase HVY12_RS21030 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVY12_RS21035 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVY12_RS21050 ENOG4105C2W permease HVY12_RS21055 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVY12_RS21060 ENOG4105K89 arsenate reductase HVY12_RS21065 ENOG4105ERG peptidase m48, ste24p HVY12_RS21070 ENOG4105C02 permease HVY12_RS21075 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVY12_RS21080 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVY12_RS21090 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY12_RS21100 ENOG4105CGZ zinc metallopeptidase HVY12_RS21105 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HVY12_RS21110 ENOG4106KED esterase YpfH HVY12_RS21125 ENOG4105KUZ arsenate reductase HVY12_RS21135 ENOG4105BZS acriflavin resistance protein HVY12_RS21145 ENOG4105BZU Histidine kinase HVY12_RS21150 ENOG4105BZ8 glutamate synthase HVY12_RS21160 ENOG4108PVD exported protein HVY12_RS21165 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY12_RS21170 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY12_RS21175 ENOG4105C6K Malic enzyme HVY12_RS21180 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVY12_RS21185 ENOG4106S4J ethanolamine utilization protein EutP HVY12_RS21190 ENOG4105NDK ethanolamine utilization protein HVY12_RS21195 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVY12_RS21200 ENOG4107WUY phosphate acetyltransferase HVY12_RS21205 ENOG4105KNY Microcompartments protein HVY12_RS21210 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVY12_RS21215 ENOG4108EKI Dehydrogenase HVY12_RS21220 ENOG4107RWI ethanolamine utilization protein eutJ HVY12_RS21225 ENOG4105C0A alcohol dehydrogenase HVY12_RS21230 ENOG4105ENY Ethanolamine utilization protein eutH HVY12_RS21235 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVY12_RS21240 ENOG4105CPD ethanolamine ammonia-lyase HVY12_RS21250 ENOG4106D67 ethanolamine utilization protein HVY12_RS21255 ENOG4108X49 Ethanolamine utilization protein EutK HVY12_RS21260 ENOG4108K3Z AraC family transcriptional regulator HVY12_RS21270 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVY12_RS21280 ENOG4105QZU Inner membrane protein YfeZ HVY12_RS21285 ENOG4105E7K (LipO)protein HVY12_RS21290 ENOG4105EZR dyp-type peroxidase family protein HVY12_RS21300 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVY12_RS21305 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVY12_RS21310 ENOG4108I5D sulfate abc transporter HVY12_RS21315 ENOG4105ECW sulfate abc transporter HVY12_RS21320 ENOG4108IJ6 ABC transporter HVY12_RS21325 ENOG4105C6T cysteine synthase HVY12_RS21330 ENOG4105WEC Molybdate metabolism regulator HVY12_RS21335 ENOG4105M0Y HVY12_RS21345 ENOG4105C5Y PTS System HVY12_RS21350 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY12_RS21360 ENOG4105C6T cysteine synthase HVY12_RS21380 ENOG4105VRT cytoplasmic protein HVY12_RS21385 ENOG4105DHU Bile acid HVY12_RS21390 ENOG4108M0I Transcriptional regulator HVY12_RS21395 ENOG4108NFH Sugar hydrolase HVY12_RS21400 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVY12_RS21405 ENOG4105EAA nucleoside HVY12_RS21415 ENOG4105CN8 Transcriptional regulator HVY12_RS21445 ENOG4105GXM Putative transcription regulator (DUF1323) HVY12_RS21450 ENOG4105HZG regulatoR HVY12_RS21465 ENOG4108KMM Diguanylate cyclase HVY12_RS21470 ENOG4105D9N nucleoside HVY12_RS21480 ENOG4109076 Conserved Protein HVY12_RS21485 ENOG4105VCT ion-transport protein YfeO HVY12_RS21495 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVY12_RS21500 ENOG410863U PTS System HVY12_RS21505 ENOG4105DC7 peptidase M24 HVY12_RS21510 ENOG4105CN9 Peptidase m42 family protein HVY12_RS21515 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY12_RS21520 ENOG4108CIP transcriptional regulator HVY12_RS21525 ENOG4105DY9 regulatoR HVY12_RS21530 ENOG4108HRK Histidine kinase HVY12_RS21535 ENOG4105CHM Aminotransferase HVY12_RS21545 ENOG4105D1S lipid A biosynthesis HVY12_RS21550 ENOG4105W9M Membrane HVY12_RS21555 ENOG4105D70 Integrase catalytic subunit HVY12_RS21560 ENOG4105F5W AtP-binding protein HVY12_RS21625 ENOG4105S64 Formate nitrite transporter HVY12_RS21630 ENOG410903C (LipO)protein HVY12_RS21635 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVY12_RS21640 ENOG4105KZW UPF0381 protein HVY12_RS21650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVY12_RS21655 ENOG4108BY2 phosphohistidine phosphatase HVY12_RS21670 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HVY12_RS21675 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HVY12_RS21680 ENOG4105EJ9 Membrane HVY12_RS21685 ENOG4108BPE -transporting atpase HVY12_RS21690 ENOG4105MH2 YfcL protein HVY12_RS21700 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY12_RS21705 ENOG4105F9N Major Facilitator Superfamily HVY12_RS21710 ENOG4106WZ1 flagella biosynthesis regulator HVY12_RS21720 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY12_RS21730 ENOG4105DQR SNARE associated Golgi HVY12_RS21740 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVY12_RS21745 ENOG4108S3P Sporulation domain protein HVY12_RS21750 ENOG4105E96 Colicin v production protein HVY12_RS21755 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVY12_RS21760 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY12_RS21765 ENOG4105E89 ABC transporter HVY12_RS21770 ENOG4105E89 ABC transporter HVY12_RS21775 ENOG4105DSP amino acid AbC transporter HVY12_RS21780 ENOG4106YG3 ABC transporter HVY12_RS21785 ENOG4108JEH abc transporter atp-binding protein HVY12_RS21790 ENOG4105DNE Transposase HVY12_RS21795 ENOG4105ECP epimerase HVY12_RS21800 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVY12_RS21805 ENOG4105CYM Glutathione S-transferase HVY12_RS21810 ENOG4108SHQ Glutathione S-transferase HVY12_RS21815 ENOG4108RE9 Phosphodiesterase HVY12_RS21820 ENOG4105PTV Nudix Hydrolase HVY12_RS21825 ENOG4105K2J Transcriptional regulator HVY12_RS21840 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY12_RS21845 ENOG4108HHA Transketolase HVY12_RS21850 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVY12_RS21855 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVY12_RS21860 ENOG4105C6K Malic enzyme HVY12_RS21865 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVY12_RS21875 ENOG4105XWI UPF0304 protein HVY12_RS21880 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVY12_RS21885 ENOG4107QWE )-transporter HVY12_RS21895 ENOG4105CHM Aminotransferase HVY12_RS21900 ENOG4107NQ8 LysR family Transcriptional regulator HVY12_RS21920 ENOG4105GKE subunit e HVY12_RS21925 ENOG4107QIZ NADH dehydrogenase HVY12_RS21930 ENOG4108IEH NADH dehydrogenase subunit g HVY12_RS21945 ENOG4107UFS subunit j HVY12_RS21955 ENOG4105D65 subunit l HVY12_RS21960 ENOG4105C8S subunit m HVY12_RS21970 ENOG4105GDX Domain of unknown function (DUF1877) HVY12_RS21975 ENOG4107VAM peptidase, m28 HVY12_RS21980 ENOG4105CP2 von willebrand factor, type a HVY12_RS21990 ENOG4107YB6 acetyltransferase, (GNAT) family HVY12_RS21995 ENOG4105TNS Conserved Protein HVY12_RS22000 ENOG4105E4F Isochorismate synthase HVY12_RS22015 ENOG4108IPT Naphthoate synthase HVY12_RS22020 ENOG4105DNI Converts SHCHC to OSB (By similarity) HVY12_RS22025 ENOG4105CEY Amp-dependent synthetase and ligase HVY12_RS22030 ENOG4106GZG polymyxin resistance protein B HVY12_RS22055 ENOG4105C3I Nad-dependent epimerase dehydratase HVY12_RS22070 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) HVY12_RS22080 ENOG4108UII YfaZ family HVY12_RS22085 ENOG4108EWA cinA-like protein HVY12_RS22090 ENOG4107258 Transcriptional regulator HVY12_RS22100 ENOG4105CSP Major Facilitator Superfamily HVY12_RS22115 ENOG4105DNE Transposase HVY12_RS22120 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY12_RS22130 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVY12_RS22135 ENOG4105CXY transporter HVY12_RS22140 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVY12_RS22145 ENOG4105FQR PH-inducible protein involved in stress response HVY12_RS22150 ENOG4105XPH Ferredoxin HVY12_RS22155 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY12_RS22160 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY12_RS22165 ENOG4107GHC outer membrane autotransporter HVY12_RS22175 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY12_RS22180 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HVY12_RS22185 ENOG4108QJJ Protein of unknown function (DUF1175) HVY12_RS22190 ENOG4107S52 alpha-2-macroglobulin domain protein HVY12_RS22195 ENOG41081SK signal peptide protein HVY12_RS22200 ENOG4105EDV vault protein HVY12_RS22205 ENOG4105CHU acetyl-coa acetyltransferase HVY12_RS22210 ENOG4105CRW Short chain fatty acid transporter HVY12_RS22215 ENOG4107QNJ CoA-transferase subunit B HVY12_RS22220 ENOG4107QP7 CoA-transferase subunit A HVY12_RS22225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY12_RS22230 ENOG4105BZU Histidine kinase HVY12_RS22235 ENOG4105BZU Histidine kinase HVY12_RS22240 ENOG41068CG regulatoR HVY12_RS22245 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVY12_RS22250 ENOG4105FCK Membrane HVY12_RS22255 ENOG4105CJ2 (LipO)protein HVY12_RS22260 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY12_RS22265 ENOG4105CF1 Alkylated DNA repair protein HVY12_RS22270 ENOG4105IBP Cyclic peptide transporter HVY12_RS22285 ENOG4108ZNS ferredoxin-type protein NapF HVY12_RS22290 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVY12_RS22300 ENOG4108BGM Quinol dehydrogenase periplasmic component HVY12_RS22305 ENOG4105GXZ Ferredoxin-type protein NapH HVY12_RS22310 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVY12_RS22315 ENOG4105CUW cytochrome C-TYPE protein HVY12_RS22320 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HVY12_RS22325 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVY12_RS22330 ENOG41060IM Heme exporter protein HVY12_RS22335 ENOG4105X3C heme exporter protein HVY12_RS22345 ENOG4105DA4 cytochrome c-type biogenesis protein HVY12_RS22350 ENOG4107QX9 Thiol disulfide interChange protein HVY12_RS22355 ENOG4105KWW Biogenesis protein HVY12_RS22360 ENOG4105WH1 Two component transcriptional regulator luxr family HVY12_RS22370 ENOG4105E68 Sulfatase HVY12_RS22390 ENOG4105CFI type iii restriction protein res subunit HVY12_RS22395 ENOG4105I08 Pseudouridine synthase HVY12_RS22400 ENOG4105C2C drug resistance transporter, Bcr CflA HVY12_RS22405 ENOG4105HG6 HVY12_RS22410 ENOG4108JQ5 ABC transporter HVY12_RS22415 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVY12_RS22420 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVY12_RS22425 ENOG4105E43 Extracellular solute-binding protein, family 5 HVY12_RS22430 ENOG4105CXC rtn protein HVY12_RS22435 ENOG4107TT5 NLP P60 protein HVY12_RS22440 ENOG41076MN Phosphoesterase, PA-phosphatase related HVY12_RS22445 ENOG4105CKI cobalamin synthesis protein HVY12_RS22450 ENOG4105DEI Mannitol dehydrogenase HVY12_RS22460 ENOG4105KRS Proteinase inhibitor HVY12_RS22465 ENOG4105S8Q sugar efflux transporter HVY12_RS22470 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVY12_RS22475 ENOG4105DE4 1-phosphofructokinase HVY12_RS22480 ENOG4105DM4 PTS System HVY12_RS22485 ENOG4105DD7 kinase (PfkB family HVY12_RS22490 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVY12_RS22495 ENOG4105D9N nucleoside HVY12_RS22500 ENOG4108Y4K DNA-binding transcriptional activator HVY12_RS22510 ENOG4105D9N nucleoside HVY12_RS22515 ENOG4105DD7 kinase (PfkB family HVY12_RS22525 ENOG4105HMI Membrane HVY12_RS22530 ENOG4105DUM transcriptional regulator, lysR family HVY12_RS22535 ENOG4108IQI permease HVY12_RS22540 ENOG4105D05 Receptor HVY12_RS22555 ENOG4105DHF Membrane HVY12_RS22560 ENOG41060NJ transcriptional regulator HVY12_RS22565 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVY12_RS22570 ENOG4105C2J ABC transporter HVY12_RS22575 ENOG4108HWV )-transporter HVY12_RS22580 ENOG4107SJI Dehydrogenase HVY12_RS22585 ENOG4105BZ8 glutamate synthase HVY12_RS22590 ENOG4105Y9N Membrane HVY12_RS22595 ENOG4107GZ4 SanA protein HVY12_RS22605 ENOG41067MG lrgb family HVY12_RS22610 ENOG4105VAW lrga family HVY12_RS22615 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVY12_RS22625 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVY12_RS22630 ENOG4105KHU inner membrane protein YohD HVY12_RS22640 ENOG41061WM D-Alanyl-D-Alanine HVY12_RS22645 ENOG4105CXG d-lactate dehydrogenase HVY12_RS22650 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVY12_RS22655 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVY12_RS22660 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVY12_RS22665 ENOG4108IJ8 ABC transporter HVY12_RS22670 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVY12_RS22680 ENOG4108XDN Transcriptional regulator HVY12_RS22685 ENOG4108HRK Histidine kinase HVY12_RS22690 ENOG4108NEV two component transcriptional regulator, LytTR family HVY12_RS22695 ENOG4108W15 Protein of unknown function (DUF1456) HVY12_RS22700 ENOG4108YCW (LipO)protein HVY12_RS22705 ENOG410903U zinc ion binding HVY12_RS22710 ENOG4105DEG Vwa containing coxe family protein HVY12_RS22715 ENOG4105RD5 HVY12_RS22720 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVY12_RS22730 ENOG4108KDT Molybdate metabolism regulator HVY12_RS22735 ENOG4108KDT Molybdate metabolism regulator HVY12_RS22740 ENOG4108KDT Molybdate metabolism regulator HVY12_RS22745 ENOG4108KDT Molybdate metabolism regulator HVY12_RS22755 ENOG4105D1F ATP-binding protein HVY12_RS22760 ENOG41067AK Protein of unknown function (DUF2574) HVY12_RS22765 ENOG41063W2 Fimbrial protein HVY12_RS22770 ENOG4108MQF Chaperone HVY12_RS22775 ENOG4105CW0 outer membrane usher protein HVY12_RS22780 ENOG410662B Type-1 fimbrial protein HVY12_RS22785 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVY12_RS22790 ENOG41061MD high-affinity nickel-transporter HVY12_RS22805 ENOG4105DWF phosphomethylpyrimidine kinase HVY12_RS22810 ENOG4108UQ1 hydrolase, family 25 HVY12_RS22815 ENOG4105FDP GntR family transcriptional regulator HVY12_RS22820 ENOG4108TFM Kinase, PfkB family HVY12_RS22825 ENOG4108KD5 ADP-ribosylation crystallin J1 HVY12_RS22830 ENOG4105EAA nucleoside HVY12_RS22835 ENOG4105EIE fructose-bisphosphate aldolase HVY12_RS22845 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY12_RS22905 ENOG410607W Transposase HVY12_RS22945 ENOG4108KQ5 Integrase catalytic subunit HVY12_RS23015 ENOG4105BZU Histidine kinase HVY12_RS23050 ENOG410836F Transposase HVY12_RS23060 ENOG4105D70 Integrase catalytic subunit HVY12_RS23065 ENOG4105F5W AtP-binding protein HVY12_RS23085 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HVY12_RS23090 ENOG4105FCK Membrane HVY12_RS23185 ENOG41073YN Protein of unknown function (DUF1380) HVY12_RS23190 ENOG4106JQ7 HVY12_RS23325 ENOG4105KF5 hemolysin expression-modulating protein HVY12_RS23395 ENOG4105D70 Integrase catalytic subunit HVY12_RS23400 ENOG4105F5W AtP-binding protein HVY12_RS23440 ENOG4105CZX twitching motility protein HVY12_RS23490 ENOG4105K5T PilT protein HVY12_RS23505 ENOG4107QHF type ii secretion system protein e HVY12_RS23575 ENOG4107ZY3 Histidine kinase HVY12_RS23580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY12_RS23585 ENOG4105VT2 5-hydroxyisourate hydrolase HVY12_RS23590 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HVY12_RS23620 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVY12_RS23650 ENOG4105F5W AtP-binding protein HVY12_RS23655 ENOG4105D70 Integrase catalytic subunit HVY12_RS23660 ENOG4108SGD regulatory protein HVY12_RS23720 ENOG4106CQM replication HVY12_RS23755 ENOG4107CBI conjugal transfer fertility inhibition protein HVY12_RS23865 ENOG4105D70 Integrase catalytic subunit HVY12_RS23870 ENOG4105F5W AtP-binding protein HVY12_RS23990 ENOG41073YN Protein of unknown function (DUF1380) HVY12_RS24035 ENOG410836F Transposase