locus-tag	class	description
HVY12_RS00040	COG4695	Portal protein
HVY12_RS00130	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY12_RS00135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY12_RS00170	COG1484	DNA-dependent DNA replication
HVY12_RS00175	COG4584	PFAM Integrase catalytic
HVY12_RS00210	COG0745	RESPONSE REGULATOR receiver
HVY12_RS00215	COG2205	protein histidine kinase activity
HVY12_RS00245	COG4245	von Willebrand factor, type A
HVY12_RS00250	COG0631	protein serine/threonine phosphatase activity
HVY12_RS00255	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVY12_RS00260	COG0443	Heat shock 70 kDa protein
HVY12_RS00265	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVY12_RS00270	COG5001	Diguanylate cyclase
HVY12_RS00270	COG5002	protein histidine kinase activity
HVY12_RS00270	COG3447	MASE1 domain protein
HVY12_RS00285	COG2982	Protein involved in outer membrane biogenesis
HVY12_RS00290	COG1253	flavin adenine dinucleotide binding
HVY12_RS00295	COG1596	polysaccharide export
HVY12_RS00300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVY12_RS00305	COG3206	protein involved in exopolysaccharide biosynthesis
HVY12_RS00305	COG0489	protein tyrosine kinase activity
HVY12_RS00310	COG0463	Glycosyl transferase, family 2
HVY12_RS00315	COG1045	serine acetyltransferase
HVY12_RS00320	COG0438	transferase activity, transferring glycosyl groups
HVY12_RS00330	COG1216	Glycosyl transferase, family 2
HVY12_RS00335	COG0110	maltose O-acetyltransferase activity
HVY12_RS00340	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVY12_RS00345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY12_RS00350	COG1051	belongs to the nudix hydrolase family
HVY12_RS00355	COG0297	glycogen (starch) synthase activity
HVY12_RS00360	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVY12_RS00360	COG0662	Cupin 2, conserved barrel domain protein
HVY12_RS00365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVY12_RS00370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVY12_RS00375	COG2244	polysaccharide biosynthetic process
HVY12_RS00380	COG2327	Polysaccharide pyruvyl transferase
HVY12_RS00385	COG0438	transferase activity, transferring glycosyl groups
HVY12_RS00395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY12_RS00410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY12_RS00430	COG0438	transferase activity, transferring glycosyl groups
HVY12_RS00445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVY12_RS00485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVY12_RS00490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY12_RS00490	COG0131	Imidazoleglycerol-phosphate dehydratase
HVY12_RS00500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVY12_RS00515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY12_RS00520	COG0583	DNA-binding transcription factor activity
HVY12_RS00530	COG0531	amino acid
HVY12_RS00535	COG2925	Exonuclease
HVY12_RS00540	COG0582	viral genome integration into host DNA
HVY12_RS00560	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HVY12_RS00565	COG5532	Uncharacterized conserved protein (DUF2303)
HVY12_RS00610	COG1846	Transcriptional regulator
HVY12_RS00620	COG4725	Belongs to the MT-A70-like family
HVY12_RS00630	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVY12_RS00640	COG1403	HNH endonuclease
HVY12_RS00690	COG4626	Terminase
HVY12_RS00690	COG1802	Transcriptional regulator
HVY12_RS00700	COG4695	Portal protein
HVY12_RS00745	COG4386	tail sheath protein
HVY12_RS00765	COG4228	DNA circulation
HVY12_RS00785	COG3299	homolog of phage Mu protein gp47
HVY12_RS00790	COG3778	Protein conserved in bacteria
HVY12_RS00800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY12_RS00810	COG0463	Glycosyl transferase, family 2
HVY12_RS00815	COG2246	polysaccharide biosynthetic process
HVY12_RS00820	COG1686	Belongs to the peptidase S11 family
HVY12_RS00830	COG1289	transmembrane transporter activity
HVY12_RS00855	COG4656	Part of a membrane complex involved in electron transport
HVY12_RS00860	COG1012	belongs to the aldehyde dehydrogenase family
HVY12_RS00860	COG1454	alcohol dehydrogenase
HVY12_RS00950	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HVY12_RS00965	COG1376	ErfK ybiS ycfS ynhG family protein
HVY12_RS00975	COG0583	DNA-binding transcription factor activity
HVY12_RS00980	COG0583	DNA-binding transcription factor activity
HVY12_RS00990	COG0534	Mate efflux family protein
HVY12_RS01000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVY12_RS01005	COG0477	Major facilitator Superfamily
HVY12_RS01040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY12_RS01055	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVY12_RS01060	COG3727	T/G mismatch-specific endonuclease activity
HVY12_RS01065	COG0697	spore germination
HVY12_RS01070	COG2354	Protein conserved in bacteria
HVY12_RS01075	COG5475	Uncharacterized small protein (DUF2158)
HVY12_RS01100	COG2197	response regulator
HVY12_RS01105	COG1684	flagellar biosynthetic protein fliR
HVY12_RS01110	COG1987	bacterial-type flagellum assembly
HVY12_RS01115	COG1338	Plays a role in the flagellum-specific transport system
HVY12_RS01120	COG3190	flagellar
HVY12_RS01125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY12_RS01130	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY12_RS01135	COG1580	Controls the rotational direction of flagella during chemotaxis
HVY12_RS01140	COG3144	bacterial-type flagellum assembly
HVY12_RS01145	COG2882	bacterial-type flagellum organization
HVY12_RS01150	COG1157	protein secretion by the type III secretion system
HVY12_RS01155	COG1317	bacterial-type flagellum organization
HVY12_RS01160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY12_RS01165	COG1766	The M ring may be actively involved in energy transduction
HVY12_RS01180	COG5562	phage envelope protein
HVY12_RS01185	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVY12_RS01190	COG0425	Belongs to the sulfur carrier protein TusA family
HVY12_RS01195	COG2391	methyltransferase activity
HVY12_RS01205	COG0366	Alpha amylase catalytic
HVY12_RS01215	COG1516	flagellar protein fliS
HVY12_RS01220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVY12_RS01230	COG1191	sigma factor activity
HVY12_RS01260	COG2197	response regulator
HVY12_RS01275	COG2197	response regulator
HVY12_RS01305	COG3012	SEC-C Motif Domain Protein
HVY12_RS01305	COG3318	Belongs to the UPF0149 family
HVY12_RS01310	COG0814	amino acid
HVY12_RS01320	COG1528	Iron-storage protein
HVY12_RS01340	COG1528	Iron-storage protein
HVY12_RS01345	COG1879	ABC-type sugar transport system periplasmic component
HVY12_RS01350	COG1129	ABC transporter
HVY12_RS01355	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY12_RS01360	COG1877	trehalose-phosphatase activity
HVY12_RS01370	COG0589	response to stress
HVY12_RS01385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVY12_RS01390	COG1360	Flagellar Motor Protein
HVY12_RS01395	COG0643	Histidine kinase
HVY12_RS01395	COG2198	Histidine kinase
HVY12_RS01400	COG0835	chemotaxis
HVY12_RS01405	COG0840	transmembrane signaling receptor activity
HVY12_RS01410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVY12_RS01420	COG0745	RESPONSE REGULATOR receiver
HVY12_RS01425	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HVY12_RS01430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVY12_RS01435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVY12_RS01450	COG3102	Protein conserved in bacteria
HVY12_RS01460	COG3005	denitrification pathway
HVY12_RS01465	COG0243	molybdopterin cofactor binding
HVY12_RS01480	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVY12_RS01485	COG1801	Protein of unknown function DUF72
HVY12_RS01490	COG1335	isochorismatase
HVY12_RS01500	COG0494	nUDIX hydrolase
HVY12_RS01505	COG0217	transcriptional regulatory protein
HVY12_RS01530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVY12_RS01545	COG2719	SpoVR family
HVY12_RS01555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY12_RS01565	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVY12_RS01575	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVY12_RS01590	COG0157	Belongs to the NadC ModD family
HVY12_RS01595	COG0500	methyltransferase
HVY12_RS01600	COG1120	ATPase activity
HVY12_RS01620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS01620	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HVY12_RS01620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY12_RS01625	COG1461	Dihydroxyacetone kinase
HVY12_RS01630	COG2376	Dihydroxyacetone kinase
HVY12_RS01635	COG3284	Transcriptional regulator
HVY12_RS01645	COG0012	GTP binding
HVY12_RS01660	COG0659	secondary active sulfate transmembrane transporter activity
HVY12_RS01665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVY12_RS01690	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY12_RS01695	COG3094	Invasion gene expression up-regulator, SirB
HVY12_RS01700	COG2912	Transglutaminase-like superfamily
HVY12_RS01715	COG0387	Pfam Sodium calcium exchanger
HVY12_RS01720	COG4572	Cation transport regulator
HVY12_RS01725	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVY12_RS01730	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVY12_RS01735	COG4932	domain protein
HVY12_RS01740	COG2197	response regulator
HVY12_RS01745	COG3850	Histidine kinase
HVY12_RS01750	COG2223	nitrite transmembrane transporter activity
HVY12_RS01755	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY12_RS01760	COG1140	nitrate reductase beta subunit
HVY12_RS01765	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY12_RS01770	COG2181	nitrate reductase activity
HVY12_RS01775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVY12_RS01780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY12_RS01820	COG0788	formyltetrahydrofolate deformylase activity
HVY12_RS01830	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVY12_RS01835	COG0745	RESPONSE REGULATOR receiver
HVY12_RS01840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY12_RS01850	COG1435	thymidine kinase activity
HVY12_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
HVY12_RS01855	COG1454	alcohol dehydrogenase
HVY12_RS01860	COG2095	MarC family integral membrane protein
HVY12_RS01865	COG4166	transmembrane transport
HVY12_RS01870	COG0601	transmembrane transport
HVY12_RS01875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY12_RS01880	COG0444	Belongs to the ABC transporter superfamily
HVY12_RS01885	COG4608	Belongs to the ABC transporter superfamily
HVY12_RS01905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY12_RS01910	COG2350	Protein conserved in bacteria
HVY12_RS01915	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HVY12_RS01920	COG1607	acyl-coa hydrolase
HVY12_RS01935	COG3047	cAMP biosynthetic process
HVY12_RS01950	COG0134	indole-3-glycerol-phosphate synthase activity
HVY12_RS01950	COG0135	phosphoribosylanthranilate isomerase activity
HVY12_RS01955	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY12_RS01955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY12_RS01960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY12_RS01970	COG0613	PHP domain protein
HVY12_RS01975	COG0009	L-threonylcarbamoyladenylate synthase
HVY12_RS01980	COG4907	membrane protein (DUF2207)
HVY12_RS01985	COG1187	pseudouridine synthase activity
HVY12_RS02000	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVY12_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
HVY12_RS02010	COG0616	signal peptide processing
HVY12_RS02020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY12_RS02025	COG0583	DNA-binding transcription factor activity
HVY12_RS02045	COG3344	reverse transcriptase
HVY12_RS02050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY12_RS02060	COG0671	phosphoesterase, PA-phosphatase related
HVY12_RS02065	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVY12_RS02070	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVY12_RS02080	COG0023	Translation Initiation Factor
HVY12_RS02090	COG1349	DNA-binding transcription factor activity
HVY12_RS02100	COG5001	Diguanylate cyclase
HVY12_RS02115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY12_RS02115	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY12_RS02120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVY12_RS02130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY12_RS02145	COG2814	Major facilitator Superfamily
HVY12_RS02150	COG4172	Belongs to the ABC transporter superfamily
HVY12_RS02155	COG4172	Belongs to the ABC transporter superfamily
HVY12_RS02160	COG4171	peptide transport system, permease
HVY12_RS02165	COG4168	peptide transport system, permease
HVY12_RS02170	COG4166	transmembrane transport
HVY12_RS02180	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY12_RS02185	COG1842	Phage shock protein A
HVY12_RS02195	COG1983	PspC domain protein
HVY12_RS02205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY12_RS02210	COG3106	COG3106 Predicted ATPase
HVY12_RS02220	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVY12_RS02225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVY12_RS02230	COG4948	Mandelate Racemase Muconate Lactonizing
HVY12_RS02235	COG2866	Carboxypeptidase
HVY12_RS02240	COG4166	transmembrane transport
HVY12_RS02255	COG0668	transmembrane transport
HVY12_RS02260	COG3182	Iron-regulated membrane protein
HVY12_RS02265	COG0589	response to stress
HVY12_RS02270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY12_RS02275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY12_RS02280	COG2840	Smr protein MutS2
HVY12_RS02285	COG3706	GGDEF domain
HVY12_RS02295	COG0513	Belongs to the DEAD box helicase family
HVY12_RS02305	COG0589	response to stress
HVY12_RS02310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY12_RS02315	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVY12_RS02315	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVY12_RS02315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVY12_RS02315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY12_RS02320	COG3042	response to heat
HVY12_RS02325	COG3187	Heat shock protein
HVY12_RS02330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVY12_RS02335	COG2911	Protein conserved in bacteria
HVY12_RS02345	COG3784	Protein of unknown function (DUF1318)
HVY12_RS02350	COG0667	Aldo Keto reductase
HVY12_RS02360	COG1643	Atp-dependent helicase
HVY12_RS02365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY12_RS02370	COG1012	belongs to the aldehyde dehydrogenase family
HVY12_RS02375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVY12_RS02380	COG3038	cytochrome b561
HVY12_RS02395	COG0840	transmembrane signaling receptor activity
HVY12_RS02400	COG0583	DNA-binding transcription factor activity
HVY12_RS02405	COG5383	Protein conserved in bacteria
HVY12_RS02415	COG2841	Protein conserved in bacteria
HVY12_RS02420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY12_RS02425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY12_RS02430	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVY12_RS02435	COG0500	methyltransferase
HVY12_RS02445	COG3135	benzoate transporter
HVY12_RS02450	COG1396	sequence-specific DNA binding
HVY12_RS02455	COG0826	peptidase U32
HVY12_RS02465	COG1724	mRNA binding
HVY12_RS02470	COG1598	PFAM Uncharacterised protein family UPF0150
HVY12_RS02475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY12_RS02480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY12_RS02485	COG3842	ATPase activity
HVY12_RS02490	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY12_RS02495	COG1177	transmembrane transport
HVY12_RS02520	COG3238	Protein conserved in bacteria
HVY12_RS02525	COG1247	-acetyltransferase
HVY12_RS02530	COG2130	NADP-dependent
HVY12_RS02535	COG4772	TonB-dependent receptor
HVY12_RS02545	COG1113	amino acid transport
HVY12_RS02565	COG4584	PFAM Integrase catalytic
HVY12_RS02570	COG1484	DNA-dependent DNA replication
HVY12_RS02600	COG3706	GGDEF domain
HVY12_RS02600	COG2203	Gaf domain
HVY12_RS02600	COG4251	negative regulation of phosphorylation
HVY12_RS02600	COG5001	Diguanylate cyclase
HVY12_RS02605	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVY12_RS02615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY12_RS02620	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVY12_RS02625	COG0384	phenazine biosynthesis protein PhzF
HVY12_RS02630	COG2181	nitrate reductase activity
HVY12_RS02635	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY12_RS02640	COG1140	nitrate reductase beta subunit
HVY12_RS02645	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY12_RS02650	COG2223	nitrite transmembrane transporter activity
HVY12_RS02655	COG0697	spore germination
HVY12_RS02665	COG0437	4 iron, 4 sulfur cluster binding
HVY12_RS02670	COG2864	formate dehydrogenase
HVY12_RS02675	COG3093	addiction module antidote protein HigA
HVY12_RS02685	COG1064	alcohol dehydrogenase
HVY12_RS02705	COG1764	response to oxidative stress
HVY12_RS02715	COG2202	Pas domain
HVY12_RS02715	COG2200	EAL domain
HVY12_RS02715	COG2199	diguanylate cyclase activity
HVY12_RS02730	COG0531	amino acid
HVY12_RS02735	COG0076	glutamate decarboxylase activity
HVY12_RS02740	COG0612	Peptidase, M16
HVY12_RS02745	COG4771	TonB-dependent receptor
HVY12_RS02750	COG4178	(ABC) transporter
HVY12_RS02755	COG0641	radical SAM
HVY12_RS02760	COG3119	arylsulfatase activity
HVY12_RS02765	COG2373	Large extracellular alpha-helical protein
HVY12_RS02765	COG1388	LysM domain
HVY12_RS02765	COG4932	domain protein
HVY12_RS02770	COG2207	Transcriptional regulator
HVY12_RS02770	COG3708	Transcriptional regulator
HVY12_RS02775	COG3550	peptidyl-serine autophosphorylation
HVY12_RS02780	COG1396	sequence-specific DNA binding
HVY12_RS02795	COG3781	membrane
HVY12_RS02805	COG2199	diguanylate cyclase activity
HVY12_RS02815	COG2066	Belongs to the glutaminase family
HVY12_RS02820	COG1012	belongs to the aldehyde dehydrogenase family
HVY12_RS02825	COG0583	DNA-binding transcription factor activity
HVY12_RS02840	COG1846	Transcriptional regulator
HVY12_RS02845	COG4977	sequence-specific DNA binding
HVY12_RS02855	COG0697	spore germination
HVY12_RS02860	COG2814	Major facilitator Superfamily
HVY12_RS02875	COG3706	GGDEF domain
HVY12_RS02880	COG0339	signal peptide processing
HVY12_RS02885	COG4221	oxidoreductase activity
HVY12_RS02890	COG1802	Transcriptional regulator
HVY12_RS02900	COG0246	Mannitol dehydrogenase
HVY12_RS02910	COG4948	Mandelate Racemase Muconate Lactonizing
HVY12_RS02925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY12_RS02940	COG0243	molybdopterin cofactor binding
HVY12_RS02945	COG0437	4 iron, 4 sulfur cluster binding
HVY12_RS02950	COG3302	dmso reductase anchor subunit
HVY12_RS02955	COG3381	protein complex oligomerization
HVY12_RS02965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY12_RS02970	COG1940	carbohydrate kinase activity
HVY12_RS02975	COG0583	DNA-binding transcription factor activity
HVY12_RS02980	COG2814	Major facilitator Superfamily
HVY12_RS02995	COG3591	Belongs to the peptidase S1B family
HVY12_RS03010	COG0628	permease
HVY12_RS03015	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVY12_RS03020	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVY12_RS03030	COG0531	amino acid
HVY12_RS03040	COG3136	membrane protein required for alginate biosynthesis
HVY12_RS03045	COG0745	RESPONSE REGULATOR receiver
HVY12_RS03050	COG2205	protein histidine kinase activity
HVY12_RS03060	COG0114	fumarate hydratase activity
HVY12_RS03065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY12_RS03065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY12_RS03070	COG1482	cell wall glycoprotein biosynthetic process
HVY12_RS03075	COG5339	Protein conserved in bacteria
HVY12_RS03090	COG3250	beta-galactosidase activity
HVY12_RS03095	COG1309	transcriptional regulator
HVY12_RS03100	COG1028	Short-chain dehydrogenase reductase Sdr
HVY12_RS03105	COG1609	Transcriptional regulator
HVY12_RS03110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY12_RS03110	COG1263	PTS System
HVY12_RS03115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY12_RS03125	COG0673	inositol 2-dehydrogenase activity
HVY12_RS03165	COG4659	FMN binding
HVY12_RS03175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVY12_RS03180	COG3104	oligopeptide transport
HVY12_RS03185	COG0625	glutathione transferase activity
HVY12_RS03190	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HVY12_RS03205	COG3895	Periplasmic Protein
HVY12_RS03215	COG3133	Outer membrane lipoprotein
HVY12_RS03230	COG1566	PFAM secretion protein HlyD family protein
HVY12_RS03235	COG1289	transmembrane transporter activity
HVY12_RS03240	COG2032	superoxide dismutase activity
HVY12_RS03245	COG4989	oxidoreductase activity
HVY12_RS03250	COG3313	Fe-S protein
HVY12_RS03255	COG1309	transcriptional regulator
HVY12_RS03260	COG1902	pentaerythritol trinitrate reductase activity
HVY12_RS03265	COG0346	lactoylglutathione lyase activity
HVY12_RS03285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVY12_RS03290	COG0791	NLP P60 protein
HVY12_RS03295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY12_RS03300	COG2814	Major facilitator Superfamily
HVY12_RS03315	COG0583	DNA-binding transcription factor activity
HVY12_RS03320	COG2814	Major facilitator Superfamily
HVY12_RS03325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY12_RS03330	COG0307	riboflavin synthase, alpha
HVY12_RS03340	COG3468	outer membrane autotransporter barrel domain protein
HVY12_RS03360	COG4529	Protein conserved in bacteria
HVY12_RS03375	COG0469	pyruvate kinase activity
HVY12_RS03380	COG4238	major outer membrane lipoprotein
HVY12_RS03385	COG1376	ErfK ybiS ycfS ynhG family protein
HVY12_RS03400	COG0719	Fe-S assembly protein
HVY12_RS03405	COG0396	ATPase activity
HVY12_RS03410	COG0719	Fe-S assembly protein
HVY12_RS03415	COG0316	Belongs to the HesB IscA family
HVY12_RS03425	COG2050	protein possibly involved in aromatic compounds catabolism
HVY12_RS03430	COG0247	lactate metabolic process
HVY12_RS03430	COG0277	FAD linked oxidase domain protein
HVY12_RS03435	COG0628	permease
HVY12_RS03470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY12_RS03470	COG0574	Belongs to the PEP-utilizing enzyme family
HVY12_RS03480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY12_RS03485	COG4256	Hemin uptake protein
HVY12_RS03495	COG2200	EAL domain
HVY12_RS03500	COG0791	NLP P60 protein
HVY12_RS03510	COG0386	Belongs to the glutathione peroxidase family
HVY12_RS03530	COG4974	Belongs to the 'phage' integrase family
HVY12_RS03600	COG4695	Portal protein
HVY12_RS03680	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY12_RS03685	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY12_RS03790	COG3137	Salt-induced outer membrane protein
HVY12_RS03795	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY12_RS03805	COG3001	Fructosamine kinase
HVY12_RS03815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY12_RS03820	COG1988	membrane-bound metal-dependent
HVY12_RS03835	COG0753	catalase activity
HVY12_RS03845	COG1486	melibiose metabolic process
HVY12_RS03850	COG2169	Transcriptional regulator
HVY12_RS03850	COG1917	Cupin 2, conserved barrel domain protein
HVY12_RS03855	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY12_RS03860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY12_RS03865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY12_RS03870	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY12_RS03885	COG3678	ATP-independent chaperone mediated protein folding
HVY12_RS03915	COG0708	Exodeoxyribonuclease III
HVY12_RS03920	COG0398	Pfam SNARE associated Golgi protein
HVY12_RS03930	COG0398	Pfam SNARE associated Golgi protein
HVY12_RS03935	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY12_RS03940	COG4134	Bacterial extracellular solute-binding protein
HVY12_RS03945	COG4135	transport system, permease component
HVY12_RS03950	COG4136	ATPase activity
HVY12_RS03955	COG2897	thiosulfate sulfurtransferase activity
HVY12_RS03960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY12_RS03965	COG0494	nUDIX hydrolase
HVY12_RS03975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVY12_RS03980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY12_RS03990	COG0778	Nitroreductase
HVY12_RS03995	COG0616	signal peptide processing
HVY12_RS04005	COG0252	asparaginase activity
HVY12_RS04015	COG1335	isochorismatase
HVY12_RS04020	COG3139	Protein of unknown function (DUF1315)
HVY12_RS04030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVY12_RS04035	COG0676	glucose-6-phosphate 1-epimerase activity
HVY12_RS04040	COG0656	L-ascorbic acid biosynthetic process
HVY12_RS04045	COG3713	MltA-interacting MipA family protein
HVY12_RS04050	COG2766	serine protein kinase
HVY12_RS04060	COG2199	diguanylate cyclase activity
HVY12_RS04065	COG2199	diguanylate cyclase activity
HVY12_RS04070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY12_RS04085	COG3189	MarR family transcriptional regulator
HVY12_RS04090	COG3042	response to heat
HVY12_RS04095	COG2199	diguanylate cyclase activity
HVY12_RS04095	COG2203	Gaf domain
HVY12_RS04110	COG2261	transglycosylase associated protein
HVY12_RS04120	COG3615	Tellurite resistance protein tehB
HVY12_RS04130	COG0583	DNA-binding transcription factor activity
HVY12_RS04140	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVY12_RS04145	COG0318	PFAM AMP-dependent synthetase and ligase
HVY12_RS04150	COG3065	identical protein binding
HVY12_RS04155	COG1214	PFAM Peptidase M22, glycoprotease
HVY12_RS04160	COG1199	ATP-dependent helicase activity
HVY12_RS04165	COG0251	oxidation-reduction process
HVY12_RS04185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY12_RS04195	COG1760	l-serine dehydratase
HVY12_RS04200	COG2200	EAL domain
HVY12_RS04205	COG1253	flavin adenine dinucleotide binding
HVY12_RS04210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS04210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY12_RS04215	COG3715	PTS system
HVY12_RS04220	COG3716	PTS system mannose fructose sorbose family IID component
HVY12_RS04235	COG2226	methyltransferase
HVY12_RS04265	COG1414	Transcriptional regulator
HVY12_RS04270	COG2814	Major facilitator Superfamily
HVY12_RS04280	COG0793	Belongs to the peptidase S41A family
HVY12_RS04290	COG1956	GAF domain-containing protein
HVY12_RS04295	COG2995	paraquat-inducible protein a
HVY12_RS04300	COG3008	intermembrane lipid transfer
HVY12_RS04320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY12_RS04330	COG1276	copper resistance
HVY12_RS04335	COG2372	response to copper ion
HVY12_RS04345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY12_RS04350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY12_RS04360	COG1484	DNA-dependent DNA replication
HVY12_RS04365	COG4584	PFAM Integrase catalytic
HVY12_RS04375	COG2979	Protein of unknown function (DUF533)
HVY12_RS04385	COG3141	response to X-ray
HVY12_RS04395	COG0800	Aldolase
HVY12_RS04400	COG0129	dihydroxy-acid dehydratase activity
HVY12_RS04405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVY12_RS04415	COG1737	Transcriptional regulator
HVY12_RS04420	COG0469	pyruvate kinase activity
HVY12_RS04425	COG1560	Kdo2-lipid A biosynthetic process
HVY12_RS04430	COG0739	heme binding
HVY12_RS04435	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVY12_RS04445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY12_RS04455	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY12_RS04470	COG2894	cell division
HVY12_RS04495	COG2200	EAL domain
HVY12_RS04500	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVY12_RS04505	COG0217	transcriptional regulatory protein
HVY12_RS04520	COG1902	pentaerythritol trinitrate reductase activity
HVY12_RS04530	COG1278	Cold shock
HVY12_RS04545	COG2076	Multidrug Resistance protein
HVY12_RS04570	COG0538	isocitrate dehydrogenase activity
HVY12_RS04575	COG1187	pseudouridine synthase activity
HVY12_RS04595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVY12_RS04605	COG2205	protein histidine kinase activity
HVY12_RS04610	COG2850	peptidyl-arginine hydroxylation
HVY12_RS04620	COG3842	ATPase activity
HVY12_RS04630	COG1177	transmembrane transport
HVY12_RS04635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY12_RS04645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY12_RS04650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVY12_RS04660	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY12_RS04670	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY12_RS04675	COG4763	Acyl-transferase
HVY12_RS04680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVY12_RS04685	COG1376	ErfK ybiS ycfS ynhG family protein
HVY12_RS04685	COG1388	LysM domain
HVY12_RS04695	COG1309	transcriptional regulator
HVY12_RS04700	COG3134	Outer membrane lipoprotein
HVY12_RS04705	COG1252	NADH dehydrogenase
HVY12_RS04720	COG0510	thiamine kinase activity
HVY12_RS04725	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVY12_RS04730	COG5633	Lipoprotein
HVY12_RS04735	COG0537	adenosine 5'-monophosphoramidase activity
HVY12_RS04745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY12_RS04745	COG1263	PTS System
HVY12_RS04750	COG0084	hydrolase, TatD family'
HVY12_RS04755	COG0470	DNA polymerase III
HVY12_RS04765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVY12_RS04770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY12_RS04775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY12_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
HVY12_RS04790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVY12_RS04810	COG1399	metal-binding, possibly nucleic acid-binding protein
HVY12_RS04815	COG0424	maF-like protein
HVY12_RS04820	COG0564	pseudouridine synthase activity
HVY12_RS04825	COG1530	ribonuclease E activity
HVY12_RS04830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVY12_RS04835	COG1256	bacterial-type flagellum assembly
HVY12_RS04840	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVY12_RS04840	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVY12_RS04855	COG4786	Flagellar basal body rod
HVY12_RS04860	COG4787	bacterial-type flagellum-dependent cell motility
HVY12_RS04865	COG1749	Flagellar hook protein flgE
HVY12_RS04870	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVY12_RS04875	COG1558	bacterial-type flagellum-dependent cell motility
HVY12_RS04880	COG1815	bacterial-type flagellum-dependent cell motility
HVY12_RS04885	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HVY12_RS04890	COG2747	anti-sigma28 factor FlgM
HVY12_RS04895	COG3418	PFAM FlgN family protein
HVY12_RS04900	COG0728	peptidoglycan biosynthetic process
HVY12_RS04905	COG0673	inositol 2-dehydrogenase activity
HVY12_RS04915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY12_RS04955	COG3038	cytochrome b561
HVY12_RS04960	COG2353	YceI-like domain
HVY12_RS04970	COG1560	Kdo2-lipid A biosynthetic process
HVY12_RS04985	COG5645	(Lipo)protein
HVY12_RS04990	COG2943	transferase activity, transferring hexosyl groups
HVY12_RS05005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY12_RS05010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY12_RS05035	COG2197	response regulator
HVY12_RS05050	COG1462	curli production assembly transport component CsgG
HVY12_RS05060	COG3381	protein complex oligomerization
HVY12_RS05080	COG1702	phosphate starvation-inducible protein PhoH
HVY12_RS05090	COG2822	iron ion transport
HVY12_RS05100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY12_RS05105	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY12_RS05105	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY12_RS05105	COG0506	proline dehydrogenase activity
HVY12_RS05110	COG1309	transcriptional regulator
HVY12_RS05115	COG3729	General stress protein
HVY12_RS05140	COG0583	DNA-binding transcription factor activity
HVY12_RS05170	COG0243	molybdopterin cofactor binding
HVY12_RS05175	COG3005	denitrification pathway
HVY12_RS05180	COG0745	RESPONSE REGULATOR receiver
HVY12_RS05185	COG1879	ABC-type sugar transport system periplasmic component
HVY12_RS05190	COG2205	protein histidine kinase activity
HVY12_RS05190	COG0784	Response regulator, receiver
HVY12_RS05190	COG2198	Histidine kinase
HVY12_RS05195	COG0348	domain, Protein
HVY12_RS05220	COG1278	Cold shock
HVY12_RS05225	COG1278	Cold shock
HVY12_RS05240	COG1294	oxidase, subunit
HVY12_RS05245	COG1271	oxidase subunit
HVY12_RS05250	COG1773	rubredoxin
HVY12_RS05255	COG1999	signal sequence binding
HVY12_RS05260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY12_RS05265	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVY12_RS05270	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY12_RS05275	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY12_RS05290	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY12_RS05365	COG0740	serine-type endopeptidase activity
HVY12_RS05465	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVY12_RS05470	COG1403	HNH endonuclease
HVY12_RS05530	COG1484	DNA-dependent DNA replication
HVY12_RS05535	COG1846	Transcriptional regulator
HVY12_RS05595	COG1484	DNA-dependent DNA replication
HVY12_RS05600	COG4584	PFAM Integrase catalytic
HVY12_RS05605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY12_RS05620	COG0670	Belongs to the BI1 family
HVY12_RS05625	COG2920	part of a sulfur-relay system
HVY12_RS05630	COG1254	Belongs to the acylphosphatase family
HVY12_RS05645	COG1832	CoA-binding protein
HVY12_RS05660	COG0210	DNA helicase
HVY12_RS05665	COG3304	Inner membrane component domain
HVY12_RS05670	COG1289	transmembrane transporter activity
HVY12_RS05675	COG3070	regulator of competence-specific genes
HVY12_RS05695	COG1067	ATP-dependent peptidase activity
HVY12_RS05705	COG3130	regulation of translation
HVY12_RS05710	COG3009	Protein conserved in bacteria
HVY12_RS05715	COG3008	intermembrane lipid transfer
HVY12_RS05715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY12_RS05720	COG2995	paraquat-inducible protein a
HVY12_RS05725	COG0488	(ABC) transporter
HVY12_RS05735	COG3217	Mosc domain protein beta barrel domain protein
HVY12_RS05735	COG0633	Ferredoxin
HVY12_RS05750	COG0431	NADPH-dependent FMN reductase
HVY12_RS05755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY12_RS05765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY12_RS05775	COG0308	aminopeptidase N
HVY12_RS05790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY12_RS05795	COG1448	Aminotransferase
HVY12_RS05800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVY12_RS05805	COG3108	Peptidase M15
HVY12_RS05810	COG2989	Protein conserved in bacteria
HVY12_RS05820	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVY12_RS05830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVY12_RS05835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY12_RS05840	COG3173	Aminoglycoside phosphotransferase
HVY12_RS05855	COG3214	Protein conserved in bacteria
HVY12_RS05870	COG0658	competence protein
HVY12_RS05870	COG2333	competence protein COMEC
HVY12_RS05880	COG0539	negative regulation of cytoplasmic translation
HVY12_RS05890	COG0501	Belongs to the peptidase M48B family
HVY12_RS05905	COG2323	membrane
HVY12_RS05910	COG1944	ATP diphosphatase activity
HVY12_RS05915	COG2116	formate transmembrane transporter activity
HVY12_RS05920	COG1882	Formate acetyltransferase
HVY12_RS05925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY12_RS05930	COG0457	Tetratricopeptide repeat
HVY12_RS05930	COG3118	belongs to the thioredoxin family
HVY12_RS05935	COG1215	transferase activity, transferring glycosyl groups
HVY12_RS05945	COG2199	diguanylate cyclase activity
HVY12_RS05950	COG2200	EAL domain
HVY12_RS05960	COG1335	isochorismatase
HVY12_RS05965	COG3302	dmso reductase anchor subunit
HVY12_RS05970	COG0437	4 iron, 4 sulfur cluster binding
HVY12_RS05975	COG0243	molybdopterin cofactor binding
HVY12_RS05980	COG4974	Belongs to the 'phage' integrase family
HVY12_RS06105	COG4584	PFAM Integrase catalytic
HVY12_RS06110	COG1484	DNA-dependent DNA replication
HVY12_RS06250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVY12_RS06265	COG1522	sequence-specific DNA binding
HVY12_RS06270	COG0492	ferredoxin-NADP+ reductase activity
HVY12_RS06275	COG4988	ABC transporter
HVY12_RS06280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVY12_RS06305	COG3188	usher protein
HVY12_RS06310	COG3121	Chaperone
HVY12_RS06315	COG3539	Fimbrial protein
HVY12_RS06340	COG1203	CRISPR-associated helicase, Cas3
HVY12_RS06345	COG1518	maintenance of DNA repeat elements
HVY12_RS06350	COG0542	response to heat
HVY12_RS06360	COG1278	Cold shock
HVY12_RS06370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY12_RS06375	COG2990	Protein conserved in bacteria
HVY12_RS06380	COG3593	DNA synthesis involved in DNA repair
HVY12_RS06390	COG2431	L-lysine efflux transmembrane transporter activity
HVY12_RS06400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY12_RS06405	COG0028	Belongs to the TPP enzyme family
HVY12_RS06410	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVY12_RS06415	COG0702	epimerase
HVY12_RS06420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY12_RS06425	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY12_RS06440	COG1126	abc transporter atp-binding protein
HVY12_RS06445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY12_RS06450	COG4215	(ABC) transporter
HVY12_RS06455	COG4160	amino acid transport
HVY12_RS06460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY12_RS06475	COG1177	transmembrane transport
HVY12_RS06480	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY12_RS06485	COG3842	ATPase activity
HVY12_RS06490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY12_RS06505	COG0778	Nitroreductase
HVY12_RS06515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY12_RS06530	COG3226	Transcriptional regulator
HVY12_RS06535	COG0738	Major facilitator superfamily
HVY12_RS06540	COG0561	phosphatase activity
HVY12_RS06550	COG2814	Major facilitator Superfamily
HVY12_RS06555	COG0671	phosphoesterase, PA-phosphatase related
HVY12_RS06560	COG1349	DNA-binding transcription factor activity
HVY12_RS06565	COG1686	Belongs to the peptidase S11 family
HVY12_RS06570	COG0625	glutathione transferase activity
HVY12_RS06575	COG2133	pyrroloquinoline quinone binding
HVY12_RS06585	COG1874	Beta-galactosidase
HVY12_RS06590	COG1609	Transcriptional regulator
HVY12_RS06595	COG2211	Major facilitator Superfamily
HVY12_RS06605	COG2199	diguanylate cyclase activity
HVY12_RS06610	COG2200	EAL domain
HVY12_RS06625	COG0747	negative chemotaxis
HVY12_RS06635	COG1446	asparaginase
HVY12_RS06640	COG0303	'Molybdopterin
HVY12_RS06645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY12_RS06650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY12_RS06655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY12_RS06660	COG1882	Formate acetyltransferase
HVY12_RS06665	COG0561	phosphatase activity
HVY12_RS06675	COG0488	(ABC) transporter
HVY12_RS06680	COG1376	ErfK ybiS ycfS ynhG family protein
HVY12_RS06685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY12_RS06690	COG1321	iron dependent repressor
HVY12_RS06700	COG2194	sulfuric ester hydrolase activity
HVY12_RS06705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVY12_RS06715	COG5006	permease, DMT superfamily
HVY12_RS06725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY12_RS06730	COG0765	amino acid transport
HVY12_RS06735	COG1126	abc transporter atp-binding protein
HVY12_RS06740	COG0668	transmembrane transport
HVY12_RS06755	COG4774	siderophore transport
HVY12_RS06765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY12_RS06775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY12_RS06780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY12_RS06785	COG1199	ATP-dependent helicase activity
HVY12_RS06790	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HVY12_RS06795	COG0513	Belongs to the DEAD box helicase family
HVY12_RS06800	COG1309	transcriptional regulator
HVY12_RS06810	COG1131	(ABC) transporter
HVY12_RS06815	COG0842	Transport permease protein
HVY12_RS06820	COG0842	Transport permease protein
HVY12_RS06830	COG3568	Endonuclease Exonuclease Phosphatase
HVY12_RS06835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY12_RS06840	COG0392	lysyltransferase activity
HVY12_RS06850	COG0670	Belongs to the BI1 family
HVY12_RS06855	COG0314	molybdopterin synthase activity
HVY12_RS06860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVY12_RS06870	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY12_RS06880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVY12_RS06890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY12_RS06895	COG2226	methyltransferase
HVY12_RS06910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVY12_RS06915	COG1881	PFAM PEBP family protein
HVY12_RS06920	COG4677	pectinesterase activity
HVY12_RS06925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY12_RS06930	COG0471	metal ion transport
HVY12_RS06935	COG2828	Protein conserved in bacteria
HVY12_RS06940	COG0583	DNA-binding transcription factor activity
HVY12_RS06950	COG0561	phosphatase activity
HVY12_RS06960	COG4149	molybdate abc transporter
HVY12_RS06965	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVY12_RS06975	COG3585	molybdate ion transport
HVY12_RS06975	COG2005	Transcriptional regulator
HVY12_RS06980	COG1119	ATPase activity
HVY12_RS06985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVY12_RS06990	COG1085	galactose-1-phosphate uridylyltransferase
HVY12_RS07000	COG2017	converts alpha-aldose to the beta-anomer
HVY12_RS07010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY12_RS07020	COG1230	cation diffusion facilitator family transporter
HVY12_RS07025	COG3201	nicotinamide mononucleotide transporter
HVY12_RS07065	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVY12_RS07070	COG2885	chlorophyll binding
HVY12_RS07080	COG3064	Membrane
HVY12_RS07085	COG0848	biopolymer transport protein
HVY12_RS07090	COG0811	peptide transport
HVY12_RS07095	COG0824	Thioesterase
HVY12_RS07100	COG3790	cyd operon protein YbgE
HVY12_RS07105	COG4890	Cyd operon protein YbgT
HVY12_RS07110	COG1294	oxidase, subunit
HVY12_RS07115	COG1271	oxidase subunit
HVY12_RS07120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY12_RS07130	COG4865	methylaspartate mutase activity
HVY12_RS07135	COG3799	methylaspartate ammonia-lyase activity
HVY12_RS07150	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY12_RS07150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY12_RS07155	COG0583	DNA-binding transcription factor activity
HVY12_RS07170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY12_RS07180	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY12_RS07185	COG0567	Dehydrogenase, E1 component
HVY12_RS07190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY12_RS07195	COG1053	succinate dehydrogenase
HVY12_RS07200	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVY12_RS07205	COG2009	succinate dehydrogenase
HVY12_RS07215	COG0372	Belongs to the citrate synthase family
HVY12_RS07220	COG3539	Fimbrial protein
HVY12_RS07225	COG3188	usher protein
HVY12_RS07230	COG3121	Chaperone
HVY12_RS07235	COG3539	Fimbrial protein
HVY12_RS07240	COG3180	Ammonia monooxygenase
HVY12_RS07255	COG1984	allophanate hydrolase subunit 2
HVY12_RS07260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVY12_RS07265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVY12_RS07275	COG0415	Belongs to the DNA photolyase family
HVY12_RS07280	COG3272	Protein of unknown function (DUF1722)
HVY12_RS07300	COG3209	COG3209 Rhs family protein
HVY12_RS07310	COG4584	PFAM Integrase catalytic
HVY12_RS07315	COG1484	DNA-dependent DNA replication
HVY12_RS07345	COG2205	protein histidine kinase activity
HVY12_RS07350	COG0745	RESPONSE REGULATOR receiver
HVY12_RS07355	COG0033	Phosphoglucomutase
HVY12_RS07360	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVY12_RS07365	COG0596	Alpha beta hydrolase
HVY12_RS07375	COG0716	FMN binding
HVY12_RS07385	COG0735	belongs to the Fur family
HVY12_RS07405	COG1263	PTS System
HVY12_RS07405	COG2190	(PTS) system
HVY12_RS07405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY12_RS07415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY12_RS07420	COG1846	Transcriptional regulator
HVY12_RS07420	COG1940	carbohydrate kinase activity
HVY12_RS07425	COG0647	UMP catabolic process
HVY12_RS07430	COG0367	asparagine synthase
HVY12_RS07475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY12_RS07485	COG1702	phosphate starvation-inducible protein PhoH
HVY12_RS07495	COG4535	Mg2 and Co2 transporter CorC
HVY12_RS07500	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVY12_RS07505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY12_RS07510	COG0765	amino acid transport
HVY12_RS07515	COG0765	amino acid transport
HVY12_RS07520	COG1126	abc transporter atp-binding protein
HVY12_RS07530	COG0443	Heat shock 70 kDa protein
HVY12_RS07535	COG2214	Heat shock protein DnaJ domain protein
HVY12_RS07545	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY12_RS07555	COG2888	peptidyl-tyrosine sulfation
HVY12_RS07570	COG1466	dna polymerase III delta subunit
HVY12_RS07580	COG0406	alpha-ribazole phosphatase activity
HVY12_RS07585	COG0799	negative regulation of ribosome biogenesis
HVY12_RS07595	COG0768	penicillin binding
HVY12_RS07600	COG0772	Belongs to the SEDS family
HVY12_RS07605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY12_RS07610	COG1686	Belongs to the peptidase S11 family
HVY12_RS07630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY12_RS07635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY12_RS07655	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY12_RS07660	COG4565	transcriptional regulatory protein
HVY12_RS07665	COG3290	protein histidine kinase activity
HVY12_RS07670	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HVY12_RS07680	COG2301	Belongs to the HpcH HpaI aldolase family
HVY12_RS07685	COG3051	citrate lyase alpha subunit
HVY12_RS07700	COG0471	metal ion transport
HVY12_RS07705	COG3719	Belongs to the RNase T2 family
HVY12_RS07710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY12_RS07715	COG0589	response to stress
HVY12_RS07720	COG3634	alkyl hydroperoxide reductase activity
HVY12_RS07725	COG0450	alkyl hydroperoxide reductase
HVY12_RS07730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY12_RS07735	COG0583	DNA-binding transcription factor activity
HVY12_RS07740	COG3969	phosphoadenosine phosphosulfate
HVY12_RS07745	COG1475	DNA binding
HVY12_RS07750	COG0436	Aminotransferase
HVY12_RS07755	COG0371	Dehydrogenase
HVY12_RS07760	COG2879	small protein
HVY12_RS07765	COG1966	Carbon starvation protein
HVY12_RS07770	COG2050	protein possibly involved in aromatic compounds catabolism
HVY12_RS07775	COG1028	Short-chain dehydrogenase reductase Sdr
HVY12_RS07780	COG3433	isochorismatase activity
HVY12_RS07780	COG1535	isochorismatase
HVY12_RS07785	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVY12_RS07790	COG1169	isochorismate synthase
HVY12_RS07795	COG4592	Periplasmic binding protein
HVY12_RS07805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY12_RS07810	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY12_RS07815	COG1120	ATPase activity
HVY12_RS07820	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY12_RS07825	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVY12_RS07825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVY12_RS07830	COG3251	PFAM MbtH domain protein
HVY12_RS07835	COG2382	esterase
HVY12_RS07840	COG4771	TonB-dependent receptor
HVY12_RS07845	COG2977	Belongs to the P-Pant transferase superfamily
HVY12_RS07870	COG2315	Protein conserved in bacteria
HVY12_RS07875	COG0778	Nitroreductase
HVY12_RS07880	COG0668	transmembrane transport
HVY12_RS07885	COG1113	amino acid transport
HVY12_RS07890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY12_RS07895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY12_RS07900	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY12_RS07905	COG1538	Outer membrane efflux protein
HVY12_RS07910	COG0745	RESPONSE REGULATOR receiver
HVY12_RS07915	COG5002	protein histidine kinase activity
HVY12_RS07920	COG1215	transferase activity, transferring glycosyl groups
HVY12_RS07925	COG4783	chaperone-mediated protein folding
HVY12_RS07940	COG2076	Multidrug Resistance protein
HVY12_RS07950	COG4571	Outer membrane protease
HVY12_RS07980	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY12_RS08015	COG1196	nuclear chromosome segregation
HVY12_RS08065	COG1030	water channel activity
HVY12_RS08085	COG4220	transposase activity
HVY12_RS08100	COG3772	lysozyme
HVY12_RS08110	COG2207	Transcriptional regulator
HVY12_RS08115	COG3272	Protein of unknown function (DUF1722)
HVY12_RS08160	COG2207	Transcriptional regulator
HVY12_RS08165	COG1881	PFAM PEBP family protein
HVY12_RS08170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY12_RS08180	COG2076	Multidrug Resistance protein
HVY12_RS08265	COG0582	viral genome integration into host DNA
HVY12_RS08280	COG2501	S4 domain
HVY12_RS08285	COG1988	membrane-bound metal-dependent
HVY12_RS08295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY12_RS08310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVY12_RS08315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVY12_RS08320	COG0549	Belongs to the carbamate kinase family
HVY12_RS08330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY12_RS08335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY12_RS08340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY12_RS08345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY12_RS08350	COG3257	ureidoglycine aminohydrolase activity
HVY12_RS08355	COG1929	Belongs to the glycerate kinase type-1 family
HVY12_RS08360	COG2233	PERMEase
HVY12_RS08370	COG1953	Uracil, thiamine, allantoin
HVY12_RS08375	COG2084	Dehydrogenase
HVY12_RS08380	COG3622	Belongs to the hyi family
HVY12_RS08385	COG3960	tartronate-semialdehyde synthase activity
HVY12_RS08390	COG1414	Transcriptional regulator
HVY12_RS08410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVY12_RS08415	COG4181	ATPase activity
HVY12_RS08420	COG2755	lipolytic protein G-D-S-L family
HVY12_RS08425	COG0300	oxidoreductase activity
HVY12_RS08430	COG3118	belongs to the thioredoxin family
HVY12_RS08435	COG0390	transport system, permease component
HVY12_RS08440	COG4619	ABC transporter
HVY12_RS08445	COG0330	HflC and HflK could
HVY12_RS08450	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY12_RS08475	COG0789	Transcriptional regulator
HVY12_RS08500	COG0531	amino acid
HVY12_RS08510	COG2217	Heavy metal translocating P-type atpase
HVY12_RS08515	COG3735	TraB family
HVY12_RS08520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY12_RS08525	COG0737	Belongs to the 5'-nucleotidase family
HVY12_RS08530	COG2223	nitrite transmembrane transporter activity
HVY12_RS08535	COG4651	solute:proton antiporter activity
HVY12_RS08535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY12_RS08540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY12_RS08575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVY12_RS08585	COG2832	Protein of unknown function (DUF454)
HVY12_RS08590	COG3923	Primosomal replication protein n
HVY12_RS08600	COG3264	Mechanosensitive ion channel
HVY12_RS08600	COG1196	nuclear chromosome segregation
HVY12_RS08605	COG1309	transcriptional regulator
HVY12_RS08610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY12_RS08615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY12_RS08630	COG0110	maltose O-acetyltransferase activity
HVY12_RS08640	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY12_RS08645	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVY12_RS08655	COG3695	enzyme binding
HVY12_RS08660	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVY12_RS08665	COG1946	Acyl-CoA thioesterase
HVY12_RS08670	COG0004	ammonium transporteR
HVY12_RS08675	COG0347	Belongs to the P(II) protein family
HVY12_RS08680	COG1132	(ABC) transporter
HVY12_RS08685	COG1132	(ABC) transporter
HVY12_RS08690	COG1522	sequence-specific DNA binding
HVY12_RS08700	COG4533	DNA binding
HVY12_RS08710	COG0824	Thioesterase
HVY12_RS08715	COG1555	photosystem II stabilization
HVY12_RS08720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY12_RS08725	COG0776	regulation of translation
HVY12_RS08730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVY12_RS08750	COG0271	Belongs to the BolA IbaG family
HVY12_RS08755	COG3056	Lipoprotein
HVY12_RS08760	COG2223	nitrite transmembrane transporter activity
HVY12_RS08765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVY12_RS08770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVY12_RS08775	COG1845	cytochrome c oxidase, subunit III
HVY12_RS08780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVY12_RS08790	COG2814	Major facilitator Superfamily
HVY12_RS08800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVY12_RS08805	COG0693	protein deglycase activity
HVY12_RS08820	COG0142	geranyltranstransferase activity
HVY12_RS08830	COG0667	Aldo Keto reductase
HVY12_RS08835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVY12_RS08840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HVY12_RS08855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY12_RS08855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY12_RS08865	COG4238	major outer membrane lipoprotein
HVY12_RS08870	COG3248	Nucleoside-binding outer membrane protein
HVY12_RS08875	COG1403	HNH endonuclease
HVY12_RS08885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY12_RS08890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY12_RS08895	COG1862	Preprotein translocase
HVY12_RS08915	COG0366	Alpha amylase catalytic
HVY12_RS08920	COG1113	amino acid transport
HVY12_RS08925	COG1114	Component of the transport system for branched-chain amino acids
HVY12_RS08930	COG5002	protein histidine kinase activity
HVY12_RS08935	COG0745	RESPONSE REGULATOR receiver
HVY12_RS08940	COG0420	3'-5' exonuclease activity
HVY12_RS08945	COG0419	ATPase involved in DNA repair
HVY12_RS08950	COG2814	Major facilitator Superfamily
HVY12_RS08955	COG1940	carbohydrate kinase activity
HVY12_RS08970	COG4126	flavin adenine dinucleotide binding
HVY12_RS08990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVY12_RS08995	COG3706	GGDEF domain
HVY12_RS09005	COG1785	Belongs to the alkaline phosphatase family
HVY12_RS09015	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY12_RS09035	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVY12_RS09040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY12_RS09045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY12_RS09050	COG3468	outer membrane autotransporter barrel domain protein
HVY12_RS09055	COG0113	porphobilinogen synthase activity
HVY12_RS09060	COG2175	clavaminate synthase activity
HVY12_RS09065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY12_RS09075	COG4521	taurine ABC transporter
HVY12_RS09080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HVY12_RS09085	COG1215	transferase activity, transferring glycosyl groups
HVY12_RS09110	COG3122	Protein conserved in bacteria
HVY12_RS09115	COG2814	Major facilitator Superfamily
HVY12_RS09150	COG1414	Transcriptional regulator
HVY12_RS09155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVY12_RS09165	COG1609	Transcriptional regulator
HVY12_RS09175	COG2223	nitrite transmembrane transporter activity
HVY12_RS09180	COG0110	maltose O-acetyltransferase activity
HVY12_RS09185	COG0402	S-adenosylhomocysteine deaminase activity
HVY12_RS09190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY12_RS09200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY12_RS09205	COG2079	MmgE PrpD family protein
HVY12_RS09210	COG0372	Belongs to the citrate synthase family
HVY12_RS09215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVY12_RS09220	COG3829	transcription factor binding
HVY12_RS09235	COG1280	lysine exporter protein (LysE YggA)
HVY12_RS09240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HVY12_RS09265	COG0402	S-adenosylhomocysteine deaminase activity
HVY12_RS09270	COG0549	Belongs to the carbamate kinase family
HVY12_RS09275	COG1304	FMN binding
HVY12_RS09280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY12_RS09290	COG0666	response to abiotic stimulus
HVY12_RS09300	COG0583	DNA-binding transcription factor activity
HVY12_RS09305	COG2771	luxR family
HVY12_RS09305	COG2200	EAL domain
HVY12_RS09310	COG1556	Lactate utilization protein
HVY12_RS09315	COG1139	Iron-sulfur cluster binding protein
HVY12_RS09320	COG0247	lactate metabolic process
HVY12_RS09325	COG1620	l-lactate permease
HVY12_RS09330	COG2207	Transcriptional regulator
HVY12_RS09335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY12_RS09345	COG3059	membrane
HVY12_RS09370	COG5002	protein histidine kinase activity
HVY12_RS09390	COG1064	alcohol dehydrogenase
HVY12_RS09395	COG0656	L-ascorbic acid biosynthetic process
HVY12_RS09400	COG0656	L-ascorbic acid biosynthetic process
HVY12_RS09405	COG0667	Aldo Keto reductase
HVY12_RS09415	COG0702	epimerase
HVY12_RS09460	COG1120	ATPase activity
HVY12_RS09465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY12_RS09480	COG3477	response to acidic pH
HVY12_RS09505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY12_RS09525	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVY12_RS09540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY12_RS09545	COG1690	Belongs to the RtcB family
HVY12_RS09550	COG0454	-acetyltransferase
HVY12_RS09570	COG1943	Transposase
HVY12_RS09575	COG0791	NLP P60 protein
HVY12_RS09580	COG3034	peptidoglycan biosynthetic process
HVY12_RS09585	COG0121	glutamine amidotransferase
HVY12_RS09595	COG1960	acyl-CoA dehydrogenase activity
HVY12_RS09605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY12_RS09625	COG3501	Rhs element vgr protein
HVY12_RS09650	COG2885	chlorophyll binding
HVY12_RS09660	COG4584	PFAM Integrase catalytic
HVY12_RS09665	COG1484	DNA-dependent DNA replication
HVY12_RS09745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY12_RS09755	COG2226	methyltransferase
HVY12_RS09765	COG0741	lytic transglycosylase activity
HVY12_RS09765	COG1388	LysM domain
HVY12_RS09770	COG2226	methyltransferase
HVY12_RS09785	COG4584	PFAM Integrase catalytic
HVY12_RS09790	COG1484	DNA-dependent DNA replication
HVY12_RS09800	COG0656	L-ascorbic acid biosynthetic process
HVY12_RS09835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY12_RS09840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HVY12_RS09845	COG2011	ABC-type metal ion transport system permease component
HVY12_RS09850	COG1464	Belongs to the NlpA lipoprotein family
HVY12_RS09860	COG1720	tRNA m6t6A37 methyltransferase activity
HVY12_RS09870	COG0791	NLP P60 protein
HVY12_RS09875	COG3015	lipoprotein NlpE involved in copper resistance
HVY12_RS09880	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY12_RS09885	COG4681	YaeQ
HVY12_RS09895	COG4568	rho-dependent transcription termination
HVY12_RS09905	COG0346	lactoylglutathione lyase activity
HVY12_RS09920	COG0587	DNA-directed DNA polymerase activity
HVY12_RS09945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVY12_RS09950	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVY12_RS09960	COG0750	zinc metalloprotease
HVY12_RS09965	COG0575	Belongs to the CDS family
HVY12_RS09970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVY12_RS09975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVY12_RS10000	COG0024	Methionine aminopeptidase
HVY12_RS10015	COG1408	metallophosphoesterase
HVY12_RS10025	COG3835	regulator
HVY12_RS10030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY12_RS10045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY12_RS10050	COG2860	membrane
HVY12_RS10075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY12_RS10080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY12_RS10085	COG1120	ATPase activity
HVY12_RS10090	COG4774	siderophore transport
HVY12_RS10095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVY12_RS10100	COG1643	Atp-dependent helicase
HVY12_RS10105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVY12_RS10115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY12_RS10125	COG0617	tRNA 3'-terminal CCA addition
HVY12_RS10130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVY12_RS10135	COG3539	Fimbrial protein
HVY12_RS10140	COG3121	Chaperone
HVY12_RS10145	COG3188	usher protein
HVY12_RS10155	COG3539	Fimbrial protein
HVY12_RS10160	COG3539	Fimbrial protein
HVY12_RS10170	COG3539	Fimbrial protein
HVY12_RS10180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HVY12_RS10185	COG5464	transposase or invertase
HVY12_RS10190	COG5464	transposase or invertase
HVY12_RS10200	COG0726	polysaccharide deacetylase
HVY12_RS10205	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS10210	COG0842	Transport permease protein
HVY12_RS10215	COG1131	(ABC) transporter
HVY12_RS10220	COG0288	reversible hydration of carbon dioxide
HVY12_RS10225	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVY12_RS10230	COG4993	Dehydrogenase
HVY12_RS10235	COG2132	Multicopper oxidase
HVY12_RS10265	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVY12_RS10270	COG3064	Membrane
HVY12_RS10270	COG3064	Membrane
HVY12_RS10275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY12_RS10280	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY12_RS10285	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVY12_RS10290	COG2186	Transcriptional regulator
HVY12_RS10295	COG1113	amino acid transport
HVY12_RS10300	COG3725	Membrane protein required for beta-lactamase induction
HVY12_RS10305	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY12_RS10310	COG0157	Belongs to the NadC ModD family
HVY12_RS10315	COG4969	Belongs to the N-Me-Phe pilin family
HVY12_RS10320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY12_RS10325	COG1459	type II secretion system
HVY12_RS10340	COG0237	dephospho-CoA kinase activity
HVY12_RS10355	COG0494	nUDIX hydrolase
HVY12_RS10375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVY12_RS10380	COG0849	cell division
HVY12_RS10385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVY12_RS10390	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY12_RS10405	COG0772	Belongs to the SEDS family
HVY12_RS10420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVY12_RS10425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY12_RS10430	COG0768	penicillin binding
HVY12_RS10435	COG3116	cell division
HVY12_RS10450	COG1609	Transcriptional regulator
HVY12_RS10460	COG0440	acetolactate synthase activity
HVY12_RS10465	COG0028	Belongs to the TPP enzyme family
HVY12_RS10470	COG0583	DNA-binding transcription factor activity
HVY12_RS10505	COG4143	(ABC) transporter
HVY12_RS10510	COG1178	ABC-type Fe3 transport system permease component
HVY12_RS10515	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HVY12_RS10520	COG0586	Pfam SNARE associated Golgi protein
HVY12_RS10525	COG4977	sequence-specific DNA binding
HVY12_RS10545	COG0235	Class ii aldolase
HVY12_RS10550	COG0417	DNA replication proofreading
HVY12_RS10560	COG0564	pseudouridine synthase activity
HVY12_RS10565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVY12_RS10575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY12_RS10600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVY12_RS10615	COG2271	Major facilitator Superfamily
HVY12_RS10620	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY12_RS10625	COG0644	oxidoreductase
HVY12_RS10675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVY12_RS10680	COG0505	Belongs to the CarA family
HVY12_RS10700	COG1047	Peptidyl-prolyl cis-trans
HVY12_RS10715	COG0196	riboflavin kinase activity
HVY12_RS10730	COG0583	DNA-binding transcription factor activity
HVY12_RS10735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HVY12_RS10760	COG1584	GPR1 FUN34 yaaH family protein
HVY12_RS10765	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY12_RS10775	COG1115	amino acid carrier protein
HVY12_RS10790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVY12_RS10800	COG0460	homoserine dehydrogenase
HVY12_RS10800	COG0527	aspartate kinase activity
HVY12_RS10810	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVY12_RS10820	COG0745	RESPONSE REGULATOR receiver
HVY12_RS10825	COG4452	Inner membrane protein CreD
HVY12_RS10830	COG2205	protein histidine kinase activity
HVY12_RS10835	COG0745	RESPONSE REGULATOR receiver
HVY12_RS10840	COG3045	CreA protein
HVY12_RS10845	COG3708	Transcriptional regulator
HVY12_RS10845	COG2207	Transcriptional regulator
HVY12_RS10865	COG0741	lytic transglycosylase activity
HVY12_RS10870	COG0488	(ABC) transporter
HVY12_RS10875	COG1056	cytidyltransferase-related domain
HVY12_RS10875	COG3172	ATPase kinase involved in NAD metabolism
HVY12_RS10880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVY12_RS10885	COG0560	Phosphoserine phosphatase
HVY12_RS10890	COG3726	membrane protein affecting hemolysin expression
HVY12_RS10925	COG1328	CTP reductase activity
HVY12_RS10930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY12_RS10935	COG0084	hydrolase, TatD family'
HVY12_RS10940	COG4667	esterase of the alpha-beta hydrolase superfamily
HVY12_RS10950	COG2823	Periplasmic or secreted lipoprotein
HVY12_RS10960	COG1011	Hydrolase
HVY12_RS10965	COG0456	acetyltransferase
HVY12_RS10970	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVY12_RS11000	COG4114	ferric iron reductase
HVY12_RS11005	COG2197	response regulator
HVY12_RS11010	COG2197	response regulator
HVY12_RS11015	COG2966	Psort location CytoplasmicMembrane, score
HVY12_RS11030	COG1484	DNA-dependent DNA replication
HVY12_RS11045	COG1063	alcohol dehydrogenase
HVY12_RS11050	COG1802	Transcriptional regulator
HVY12_RS11055	COG0025	NhaP-type Na H and K H
HVY12_RS11060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY12_RS11070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY12_RS11075	COG0840	transmembrane signaling receptor activity
HVY12_RS11080	COG1966	Carbon starvation protein
HVY12_RS11085	COG2879	small protein
HVY12_RS11090	COG0523	cobalamin synthesis protein
HVY12_RS11105	COG1715	Restriction endonuclease
HVY12_RS11110	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVY12_RS11115	COG0732	type I restriction modification DNA specificity domain
HVY12_RS11120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HVY12_RS11130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY12_RS11140	COG2733	membrane
HVY12_RS11145	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVY12_RS11150	COG1924	4 iron, 4 sulfur cluster binding
HVY12_RS11165	COG0477	Major facilitator Superfamily
HVY12_RS11180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY12_RS11190	COG1757	Na H antiporter
HVY12_RS11200	COG3284	Transcriptional regulator
HVY12_RS11205	COG3960	tartronate-semialdehyde synthase activity
HVY12_RS11210	COG3622	Belongs to the hyi family
HVY12_RS11215	COG2084	Dehydrogenase
HVY12_RS11220	COG1929	Belongs to the glycerate kinase type-1 family
HVY12_RS11230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY12_RS11245	COG2376	Dihydroxyacetone kinase
HVY12_RS11250	COG1461	Dihydroxyacetone kinase
HVY12_RS11265	COG4382	Mu-like prophage protein Gp16
HVY12_RS11295	COG4396	Host-nuclease inhibitor protein Gam
HVY12_RS11305	COG3267	Type II secretory pathway component ExeA
HVY12_RS11305	COG3409	Peptidoglycan-binding domain 1 protein
HVY12_RS11385	COG4373	Mu-like prophage FluMu protein gp28
HVY12_RS11395	COG2369	cell adhesion
HVY12_RS11505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY12_RS11525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY12_RS11530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY12_RS11530	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS11540	COG2186	Transcriptional regulator
HVY12_RS11545	COG0246	Mannitol dehydrogenase
HVY12_RS11555	COG2610	gluconate transmembrane transporter activity
HVY12_RS11560	COG3539	Fimbrial protein
HVY12_RS11565	COG3539	Fimbrial protein
HVY12_RS11570	COG3539	Fimbrial protein
HVY12_RS11575	COG3188	usher protein
HVY12_RS11580	COG3121	Chaperone
HVY12_RS11585	COG3539	Fimbrial protein
HVY12_RS11595	COG4974	Belongs to the 'phage' integrase family
HVY12_RS11600	COG0582	viral genome integration into host DNA
HVY12_RS11605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVY12_RS11625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY12_RS11625	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HVY12_RS11655	COG0433	COG0433 Predicted ATPase
HVY12_RS11660	COG0795	lipopolysaccharide-transporting ATPase activity
HVY12_RS11665	COG0795	lipopolysaccharide-transporting ATPase activity
HVY12_RS11675	COG2927	DNA polymerase III (CHI subunit)
HVY12_RS11680	COG0525	valine-tRNA ligase activity
HVY12_RS11690	COG0456	acetyltransferase
HVY12_RS11695	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVY12_RS11705	COG2731	YhcH YjgK YiaL family protein
HVY12_RS11725	COG0251	oxidation-reduction process
HVY12_RS11735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVY12_RS11745	COG1609	Transcriptional regulator
HVY12_RS11750	COG1263	PTS System
HVY12_RS11750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY12_RS11755	COG0366	Alpha amylase catalytic
HVY12_RS11760	COG1328	CTP reductase activity
HVY12_RS11765	COG0602	queuosine metabolic process
HVY12_RS11775	COG3077	Addiction module antitoxin, RelB DinJ family
HVY12_RS11780	COG3783	Cytochrome b(562)
HVY12_RS11785	COG0312	modulator of DNA gyrase
HVY12_RS11795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVY12_RS11810	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY12_RS11815	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY12_RS11820	COG1129	ABC transporter
HVY12_RS11825	COG1879	ABC-type sugar transport system periplasmic component
HVY12_RS11830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVY12_RS11835	COG2190	(PTS) system
HVY12_RS11835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY12_RS11835	COG1263	PTS System
HVY12_RS11840	COG2723	6-phospho-beta-galactosidase activity
HVY12_RS11845	COG3711	transcriptional antiterminator
HVY12_RS11850	COG2105	PFAM AIG2 family protein
HVY12_RS11855	COG2911	Protein conserved in bacteria
HVY12_RS11860	COG0729	surface antigen
HVY12_RS11870	COG1253	flavin adenine dinucleotide binding
HVY12_RS11880	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY12_RS11885	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVY12_RS11890	COG0737	Belongs to the 5'-nucleotidase family
HVY12_RS11895	COG1733	regulation of RNA biosynthetic process
HVY12_RS11900	COG0702	epimerase
HVY12_RS11905	COG0697	spore germination
HVY12_RS11925	COG1113	amino acid transport
HVY12_RS11930	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY12_RS11935	COG3061	Opacity-associated protein A
HVY12_RS11940	COG1309	transcriptional regulator
HVY12_RS11955	COG1024	Enoyl-CoA hydratase
HVY12_RS11960	COG4670	ketone body catabolic process
HVY12_RS11965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY12_RS11970	COG2271	Major facilitator Superfamily
HVY12_RS11980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVY12_RS12020	COG3414	Phosphotransferase system galactitol-specific IIB component
HVY12_RS12025	COG3037	sugar-specific permease SgaT UlaA
HVY12_RS12040	COG1073	alpha beta
HVY12_RS12045	COG3650	response to hydrogen peroxide
HVY12_RS12055	COG1960	acyl-CoA dehydrogenase activity
HVY12_RS12060	COG0754	glutathionylspermidine amidase activity
HVY12_RS12065	COG5463	Belongs to the UPF0441 family
HVY12_RS12070	COG3766	membrane
HVY12_RS12080	COG1842	Phage shock protein A
HVY12_RS12085	COG3789	protein conserved in bacteria
HVY12_RS12090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY12_RS12095	COG0557	exoribonuclease II activity
HVY12_RS12110	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVY12_RS12115	COG0330	HflC and HflK could
HVY12_RS12120	COG0330	HflC and HflK could
HVY12_RS12125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVY12_RS12145	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY12_RS12150	COG0802	atpase or kinase
HVY12_RS12155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVY12_RS12155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVY12_RS12195	COG1511	domain protein
HVY12_RS12195	COG3264	Mechanosensitive ion channel
HVY12_RS12210	COG0531	amino acid
HVY12_RS12220	COG1053	succinate dehydrogenase
HVY12_RS12225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY12_RS12240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY12_RS12245	COG3040	lipid binding
HVY12_RS12250	COG2076	Multidrug Resistance protein
HVY12_RS12255	COG5510	response to toxic substance
HVY12_RS12260	COG5510	response to toxic substance
HVY12_RS12270	COG1509	lysine 2,3-aminomutase activity
HVY12_RS12295	COG0531	amino acid
HVY12_RS12300	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVY12_RS12305	COG1027	Aspartate ammonia-lyase
HVY12_RS12310	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY12_RS12320	COG4232	protein-disulfide reductase activity
HVY12_RS12325	COG1309	transcriptional regulator
HVY12_RS12335	COG3710	Transcriptional regulator
HVY12_RS12340	COG0531	amino acid
HVY12_RS12345	COG1982	Orn Lys Arg decarboxylase major
HVY12_RS12350	COG3104	oligopeptide transport
HVY12_RS12355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVY12_RS12370	COG2388	GCN5-related N-acetyl-transferase
HVY12_RS12375	COG3592	Divergent 4Fe-4S mono-cluster
HVY12_RS12380	COG3290	protein histidine kinase activity
HVY12_RS12385	COG4565	transcriptional regulatory protein
HVY12_RS12390	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY12_RS12395	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY12_RS12395	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY12_RS12400	COG3647	Membrane
HVY12_RS12405	COG2211	Major facilitator Superfamily
HVY12_RS12410	COG1486	melibiose metabolic process
HVY12_RS12415	COG2169	Transcriptional regulator
HVY12_RS12420	COG1982	Orn Lys Arg decarboxylase major
HVY12_RS12425	COG2207	Transcriptional regulator
HVY12_RS12430	COG0531	amino acid
HVY12_RS12435	COG2194	sulfuric ester hydrolase activity
HVY12_RS12440	COG0745	RESPONSE REGULATOR receiver
HVY12_RS12445	COG0642	Histidine kinase
HVY12_RS12455	COG0477	Major facilitator Superfamily
HVY12_RS12470	COG2824	Alkylphosphonate utilization operon protein PhnA
HVY12_RS12480	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVY12_RS12490	COG0698	ribose 5-phosphate isomerase
HVY12_RS12495	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVY12_RS12505	COG1566	PFAM secretion protein HlyD family protein
HVY12_RS12510	COG1289	transmembrane transporter activity
HVY12_RS12530	COG0601	transmembrane transport
HVY12_RS12545	COG4608	Belongs to the ABC transporter superfamily
HVY12_RS12550	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY12_RS12555	COG1301	dicarboxylic acid transport
HVY12_RS12560	COG4235	cytochrome complex assembly
HVY12_RS12565	COG3088	subunit of a heme lyase
HVY12_RS12570	COG1138	Cytochrome C-type biogenesis protein
HVY12_RS12575	COG3301	Polysulphide reductase, NrfD
HVY12_RS12580	COG0437	4 iron, 4 sulfur cluster binding
HVY12_RS12585	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HVY12_RS12595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY12_RS12600	COG3162	membrane
HVY12_RS12610	COG0025	NhaP-type Na H and K H
HVY12_RS12615	COG2252	PERMEase
HVY12_RS12620	COG0789	Transcriptional regulator
HVY12_RS12625	COG2207	Transcriptional regulator
HVY12_RS12630	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY12_RS12640	COG0629	single-stranded DNA binding
HVY12_RS12645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVY12_RS12650	COG2315	Protein conserved in bacteria
HVY12_RS12655	COG0432	Pfam Uncharacterised protein family UPF0047
HVY12_RS12660	COG3700	Belongs to the class B bacterial acid phosphatase family
HVY12_RS12665	COG1448	Aminotransferase
HVY12_RS12670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY12_RS12675	COG0305	Participates in initiation and elongation during chromosome replication
HVY12_RS12690	COG1024	Enoyl-CoA hydratase
HVY12_RS12695	COG0477	Major facilitator Superfamily
HVY12_RS12700	COG1053	succinate dehydrogenase
HVY12_RS12705	COG0604	alcohol dehydrogenase
HVY12_RS12715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY12_RS12720	COG0735	belongs to the Fur family
HVY12_RS12725	COG3237	CsbD-like
HVY12_RS12730	COG0534	Mate efflux family protein
HVY12_RS12740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVY12_RS12770	COG3842	ATPase activity
HVY12_RS12775	COG2182	Extracellular solute-binding protein
HVY12_RS12780	COG1175	transmembrane transport
HVY12_RS12785	COG3833	ABC-type maltose transport systems, permease component
HVY12_RS12800	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY12_RS12825	COG0527	aspartate kinase activity
HVY12_RS12830	COG3541	Predicted nucleotidyltransferase
HVY12_RS12840	COG1187	pseudouridine synthase activity
HVY12_RS12855	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVY12_RS12860	COG1410	methionine synthase
HVY12_RS12860	COG0646	methionine synthase
HVY12_RS12865	COG1414	Transcriptional regulator
HVY12_RS12875	COG2224	Isocitrate lyase
HVY12_RS12880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY12_RS12890	COG0456	acetyltransferase
HVY12_RS12920	COG0151	Belongs to the GarS family
HVY12_RS12925	COG2204	response regulator
HVY12_RS12930	COG4191	Histidine kinase
HVY12_RS12935	COG3678	ATP-independent chaperone mediated protein folding
HVY12_RS12950	COG3068	Protein conserved in bacteria
HVY12_RS12985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY12_RS12990	COG2104	thiamine diphosphate biosynthetic process
HVY12_RS13000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVY12_RS13035	COG0250	Participates in transcription elongation, termination and antitermination
HVY12_RS13040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY12_RS13075	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVY12_RS13075	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVY12_RS13115	COG4206	TonB-dependent receptor
HVY12_RS13130	COG1309	transcriptional regulator
HVY12_RS13135	COG0477	Major facilitator Superfamily
HVY12_RS13140	COG1473	amidohydrolase
HVY12_RS13150	COG0583	DNA-binding transcription factor activity
HVY12_RS13155	COG2271	Major facilitator Superfamily
HVY12_RS13160	COG4948	Mandelate Racemase Muconate Lactonizing
HVY12_RS13175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVY12_RS13200	COG2194	sulfuric ester hydrolase activity
HVY12_RS13205	COG2207	Transcriptional regulator
HVY12_RS13210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY12_RS13215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY12_RS13220	COG1882	Formate acetyltransferase
HVY12_RS13225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY12_RS13230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY12_RS13235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS13235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS13235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY12_RS13240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY12_RS13245	COG0371	Dehydrogenase
HVY12_RS13250	COG3738	Protein conserved in bacteria
HVY12_RS13255	COG0697	spore germination
HVY12_RS13265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVY12_RS13270	COG0460	homoserine dehydrogenase
HVY12_RS13270	COG0527	aspartate kinase activity
HVY12_RS13275	COG0626	cystathionine gamma-synthase activity
HVY12_RS13285	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVY12_RS13320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVY12_RS13325	COG1609	Transcriptional regulator
HVY12_RS13330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY12_RS13345	COG1575	Belongs to the MenA family. Type 1 subfamily
HVY12_RS13370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVY12_RS13380	COG1494	fructose-1,6-bisphosphatase
HVY12_RS13390	COG0589	response to stress
HVY12_RS13395	COG3691	Protein conserved in bacteria
HVY12_RS13400	COG3152	Membrane
HVY12_RS13420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVY12_RS13435	COG3678	ATP-independent chaperone mediated protein folding
HVY12_RS13440	COG0745	RESPONSE REGULATOR receiver
HVY12_RS13445	COG2205	protein histidine kinase activity
HVY12_RS13450	COG2258	MOSC domain
HVY12_RS13465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY12_RS13510	COG1012	belongs to the aldehyde dehydrogenase family
HVY12_RS13515	COG1454	alcohol dehydrogenase
HVY12_RS13520	COG3276	selenocysteine insertion sequence binding
HVY12_RS13530	COG0625	glutathione transferase activity
HVY12_RS13545	COG1566	PFAM secretion protein HlyD family protein
HVY12_RS13555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS13555	COG2213	PTS system mannitol-specific
HVY12_RS13565	COG3722	fumarate hydratase activity
HVY12_RS13590	COG5295	Hep Hag repeat protein
HVY12_RS13595	COG1620	l-lactate permease
HVY12_RS13600	COG2186	Transcriptional regulator
HVY12_RS13610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVY12_RS13615	COG1045	serine acetyltransferase
HVY12_RS13630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY12_RS13635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY12_RS13645	COG4942	peptidase
HVY12_RS13650	COG2861	carbohydrate metabolic process
HVY12_RS13655	COG1216	Glycosyl transferase, family 2
HVY12_RS13665	COG0156	8-amino-7-oxononanoate synthase activity
HVY12_RS13675	COG0859	PFAM glycosyl transferase family 9
HVY12_RS13680	COG0859	PFAM glycosyl transferase family 9
HVY12_RS13685	COG3307	-O-antigen
HVY12_RS13690	COG0859	PFAM glycosyl transferase family 9
HVY12_RS13700	COG3642	lipopolysaccharide core region biosynthetic process
HVY12_RS13705	COG1442	glycosyl transferase family 8
HVY12_RS13710	COG1442	glycosyl transferase family 8
HVY12_RS13715	COG0438	transferase activity, transferring glycosyl groups
HVY12_RS13720	COG0438	transferase activity, transferring glycosyl groups
HVY12_RS13720	COG4641	Protein conserved in bacteria
HVY12_RS13725	COG0515	serine threonine protein kinase
HVY12_RS13730	COG0438	transferase activity, transferring glycosyl groups
HVY12_RS13735	COG0859	PFAM glycosyl transferase family 9
HVY12_RS13740	COG1519	Transferase
HVY12_RS13770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVY12_RS13795	COG1561	YicC-like family, N-terminal region
HVY12_RS13800	COG2860	membrane
HVY12_RS13810	COG0194	GDP metabolic process
HVY12_RS13820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY12_RS13825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY12_RS13830	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVY12_RS13835	COG0786	glutamate:sodium symporter activity
HVY12_RS13840	COG2233	PERMEase
HVY12_RS13845	COG2982	Protein involved in outer membrane biogenesis
HVY12_RS13850	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY12_RS13855	COG2211	Major facilitator Superfamily
HVY12_RS13870	COG4584	PFAM Integrase catalytic
HVY12_RS13875	COG1484	DNA-dependent DNA replication
HVY12_RS13955	COG0697	spore germination
HVY12_RS13960	COG1464	Belongs to the NlpA lipoprotein family
HVY12_RS13980	COG2252	PERMEase
HVY12_RS13990	COG2271	Major facilitator Superfamily
HVY12_RS13995	COG2271	Major facilitator Superfamily
HVY12_RS14000	COG3851	Histidine kinase
HVY12_RS14005	COG2197	response regulator
HVY12_RS14010	COG0440	acetolactate synthase activity
HVY12_RS14015	COG0028	Belongs to the TPP enzyme family
HVY12_RS14025	COG2814	Major facilitator Superfamily
HVY12_RS14030	COG0641	radical SAM
HVY12_RS14040	COG2149	membrane
HVY12_RS14070	COG5645	(Lipo)protein
HVY12_RS14075	COG0823	Involved in the tonB-independent uptake of proteins
HVY12_RS14085	COG2271	Major facilitator Superfamily
HVY12_RS14095	COG0800	Aldolase
HVY12_RS14100	COG3734	2-keto-3-deoxy-galactonokinase
HVY12_RS14105	COG2186	Transcriptional regulator
HVY12_RS14115	COG0561	phosphatase activity
HVY12_RS14120	COG3753	Protein conserved in bacteria
HVY12_RS14125	COG0187	DNA topoisomerase II activity
HVY12_RS14135	COG0592	DNA-directed DNA polymerase activity
HVY12_RS14185	COG0814	amino acid
HVY12_RS14200	COG2091	lysine biosynthetic process via aminoadipic acid
HVY12_RS14205	COG0431	NADPH-dependent FMN reductase
HVY12_RS14210	COG2252	PERMEase
HVY12_RS14215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY12_RS14220	COG0704	Plays a role in the regulation of phosphate uptake
HVY12_RS14225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVY12_RS14230	COG0581	inorganic phosphate transmembrane transporter activity
HVY12_RS14235	COG0573	inorganic phosphate transmembrane transporter activity
HVY12_RS14240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY12_RS14245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVY12_RS14295	COG3312	ion transport
HVY12_RS14310	COG0716	FMN binding
HVY12_RS14315	COG1522	sequence-specific DNA binding
HVY12_RS14345	COG1129	ABC transporter
HVY12_RS14350	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY12_RS14355	COG1879	ABC-type sugar transport system periplasmic component
HVY12_RS14360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY12_RS14365	COG1609	Transcriptional regulator
HVY12_RS14375	COG2186	Transcriptional regulator
HVY12_RS14415	COG3085	chromosome segregation
HVY12_RS14420	COG0606	chelatase, subunit chli
HVY12_RS14440	COG3978	acetolactate synthase activity
HVY12_RS14445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY12_RS14455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY12_RS14460	COG0583	DNA-binding transcription factor activity
HVY12_RS14470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY12_RS14475	COG0210	DNA helicase
HVY12_RS14490	COG3118	belongs to the thioredoxin family
HVY12_RS14500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVY12_RS14505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVY12_RS14510	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY12_RS14515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVY12_RS14520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVY12_RS14525	COG0456	acetyltransferase
HVY12_RS14530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVY12_RS14535	COG2244	polysaccharide biosynthetic process
HVY12_RS14580	COG0641	radical SAM
HVY12_RS14585	COG3119	arylsulfatase activity
HVY12_RS14590	COG3071	HemY protein
HVY12_RS14595	COG2959	enzyme of heme biosynthesis
HVY12_RS14600	COG1587	Uroporphyrinogen-III synthase
HVY12_RS14610	COG3072	Adenylate cyclase
HVY12_RS14635	COG5567	small periplasmic lipoprotein
HVY12_RS14645	COG3159	Protein conserved in bacteria
HVY12_RS14655	COG1011	Hydrolase
HVY12_RS14660	COG0210	DNA helicase
HVY12_RS14665	COG3698	Phosphodiester glycosidase
HVY12_RS14670	COG0598	Magnesium transport protein CorA
HVY12_RS14685	COG2962	Rard protein
HVY12_RS14690	COG2050	protein possibly involved in aromatic compounds catabolism
HVY12_RS14695	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVY12_RS14700	COG0514	ATP-dependent DNA helicase (RecQ)
HVY12_RS14705	COG1280	lysine exporter protein (LysE YggA)
HVY12_RS14710	COG1280	lysine exporter protein (LysE YggA)
HVY12_RS14715	COG2267	carboxylic ester hydrolase activity
HVY12_RS14720	COG0561	phosphatase activity
HVY12_RS14725	COG0697	spore germination
HVY12_RS14730	COG0583	DNA-binding transcription factor activity
HVY12_RS14740	COG0583	DNA-binding transcription factor activity
HVY12_RS14745	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY12_RS14755	COG0549	Belongs to the carbamate kinase family
HVY12_RS14760	COG1304	FMN binding
HVY12_RS14765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY12_RS14775	COG1335	isochorismatase
HVY12_RS14780	COG0412	Dienelactone hydrolase
HVY12_RS14785	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVY12_RS14790	COG1322	Protein conserved in bacteria
HVY12_RS14800	COG3165	ubiquinone biosynthetic process from chorismate
HVY12_RS14810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY12_RS14815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY12_RS14820	COG0805	protein transport
HVY12_RS14830	COG0250	Participates in transcription elongation, termination and antitermination
HVY12_RS14840	COG0543	2 iron, 2 sulfur cluster binding
HVY12_RS14860	COG1739	Uncharacterized protein family UPF0029
HVY12_RS14865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY12_RS14870	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVY12_RS14895	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVY12_RS14900	COG0746	molybdenum cofactor guanylyltransferase activity
HVY12_RS14905	COG3084	Protein conserved in bacteria
HVY12_RS14910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVY12_RS14915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY12_RS14920	COG5339	Protein conserved in bacteria
HVY12_RS14925	COG0204	Acyl-transferase
HVY12_RS14930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVY12_RS14930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVY12_RS14950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY12_RS14960	COG2204	response regulator
HVY12_RS14965	COG3852	Histidine kinase
HVY12_RS14970	COG0174	glutamine synthetase
HVY12_RS14980	COG2188	Transcriptional regulator
HVY12_RS14985	COG1082	Xylose isomerase domain protein TIM barrel
HVY12_RS14990	COG2271	Major facilitator Superfamily
HVY12_RS14995	COG1349	DNA-binding transcription factor activity
HVY12_RS15000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY12_RS15010	COG3684	Belongs to the aldolase LacD family
HVY12_RS15015	COG1063	alcohol dehydrogenase
HVY12_RS15025	COG0477	Major facilitator Superfamily
HVY12_RS15035	COG1011	Hydrolase
HVY12_RS15050	COG0456	acetyltransferase
HVY12_RS15055	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY12_RS15070	COG2864	formate dehydrogenase
HVY12_RS15075	COG0437	4 iron, 4 sulfur cluster binding
HVY12_RS15090	COG0326	Molecular chaperone. Has ATPase activity
HVY12_RS15105	COG0235	Class ii aldolase
HVY12_RS15110	COG3623	hexulose-6-phosphate isomerase
HVY12_RS15115	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HVY12_RS15120	COG1070	Carbohydrate kinase
HVY12_RS15125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVY12_RS15130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVY12_RS15135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVY12_RS15145	COG2731	YhcH YjgK YiaL family protein
HVY12_RS15155	COG1414	Transcriptional regulator
HVY12_RS15160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS15165	COG3977	Valine--pyruvate aminotransferase
HVY12_RS15170	COG0366	Alpha amylase catalytic
HVY12_RS15175	COG2992	FlgJ-related protein
HVY12_RS15180	COG2207	Transcriptional regulator
HVY12_RS15180	COG1609	Transcriptional regulator
HVY12_RS15185	COG4214	carbohydrate transport
HVY12_RS15195	COG4213	ABC transporter substrate-binding protein
HVY12_RS15205	COG1070	Carbohydrate kinase
HVY12_RS15210	COG4682	membrane
HVY12_RS15215	COG4682	membrane
HVY12_RS15220	COG3274	enterobacterial common antigen metabolic process
HVY12_RS15250	COG1278	Cold shock
HVY12_RS15255	COG2944	sequence-specific DNA binding
HVY12_RS15270	COG2885	chlorophyll binding
HVY12_RS15275	COG0243	molybdopterin cofactor binding
HVY12_RS15280	COG0456	acetyltransferase
HVY12_RS15285	COG2818	Glycosylase
HVY12_RS15290	COG5571	outer membrane autotransporter
HVY12_RS15295	COG2223	nitrite transmembrane transporter activity
HVY12_RS15300	COG3539	Fimbrial protein
HVY12_RS15305	COG3121	Chaperone
HVY12_RS15315	COG3539	Fimbrial protein
HVY12_RS15320	COG3539	Fimbrial protein
HVY12_RS15325	COG2194	sulfuric ester hydrolase activity
HVY12_RS15340	COG0747	negative chemotaxis
HVY12_RS15345	COG0601	transmembrane transport
HVY12_RS15350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY12_RS15355	COG0444	Belongs to the ABC transporter superfamily
HVY12_RS15360	COG4608	Belongs to the ABC transporter superfamily
HVY12_RS15365	COG0814	amino acid
HVY12_RS15380	COG2194	sulfuric ester hydrolase activity
HVY12_RS15405	COG1215	transferase activity, transferring glycosyl groups
HVY12_RS15410	COG1215	transferase activity, transferring glycosyl groups
HVY12_RS15415	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVY12_RS15420	COG0457	Tetratricopeptide repeat
HVY12_RS15420	COG3118	belongs to the thioredoxin family
HVY12_RS15425	COG2200	EAL domain
HVY12_RS15425	COG2199	diguanylate cyclase activity
HVY12_RS15435	COG0612	Peptidase, M16
HVY12_RS15455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY12_RS15460	COG2200	EAL domain
HVY12_RS15465	COG2982	Protein involved in outer membrane biogenesis
HVY12_RS15470	COG0477	Major facilitator Superfamily
HVY12_RS15475	COG1295	ribonuclease BN
HVY12_RS15480	COG0583	DNA-binding transcription factor activity
HVY12_RS15485	COG2197	response regulator
HVY12_RS15495	COG0076	glutamate decarboxylase activity
HVY12_RS15505	COG2207	Transcriptional regulator
HVY12_RS15510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY12_RS15515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY12_RS15525	COG2771	luxR family
HVY12_RS15530	COG3247	response to pH
HVY12_RS15545	COG1285	pathogenesis
HVY12_RS15555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY12_RS15565	COG3721	Heme iron utilization protein
HVY12_RS15575	COG4558	Periplasmic binding protein
HVY12_RS15580	COG4771	TonB-dependent receptor
HVY12_RS15585	COG3720	iron ion transport
HVY12_RS15595	COG3065	identical protein binding
HVY12_RS15600	COG1393	Belongs to the ArsC family
HVY12_RS15605	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY12_RS15610	COG0640	Transcriptional regulator
HVY12_RS15620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY12_RS15625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVY12_RS15630	COG0339	signal peptide processing
HVY12_RS15640	COG3104	oligopeptide transport
HVY12_RS15650	COG0589	response to stress
HVY12_RS15660	COG0306	phosphate transporter
HVY12_RS15665	COG2081	HI0933 family
HVY12_RS15675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY12_RS15680	COG0842	Transport permease protein
HVY12_RS15680	COG1129	ABC transporter
HVY12_RS15685	COG0842	Transport permease protein
HVY12_RS15695	COG1124	(ABC) transporter
HVY12_RS15705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY12_RS15710	COG0601	transmembrane transport
HVY12_RS15715	COG0747	negative chemotaxis
HVY12_RS15720	COG2091	lysine biosynthetic process via aminoadipic acid
HVY12_RS15725	COG0628	permease
HVY12_RS15740	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVY12_RS15760	COG3714	YhhN family
HVY12_RS15770	COG3776	membrane
HVY12_RS15775	COG0742	ribosomal rna small subunit methyltransferase
HVY12_RS15780	COG0552	protein localization to endoplasmic reticulum
HVY12_RS15785	COG2884	Cell division ATP-binding protein ftsE
HVY12_RS15790	COG2177	Part of the ABC transporter FtsEX involved in
HVY12_RS15795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY12_RS15800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVY12_RS15805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVY12_RS15830	COG0683	leucine binding
HVY12_RS15835	COG0456	acetyltransferase
HVY12_RS15840	COG0683	leucine binding
HVY12_RS15845	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVY12_RS15850	COG4177	L-phenylalanine transmembrane transporter activity
HVY12_RS15855	COG0411	ABC transporter
HVY12_RS15860	COG0410	ABC transporter
HVY12_RS15865	COG1653	transport
HVY12_RS15870	COG1175	transmembrane transport
HVY12_RS15885	COG0584	glycerophosphoryl diester phosphodiesterase
HVY12_RS15895	COG0405	Gamma-glutamyltransferase
HVY12_RS15900	COG1247	-acetyltransferase
HVY12_RS15905	COG0673	inositol 2-dehydrogenase activity
HVY12_RS15910	COG1741	Belongs to the pirin family
HVY12_RS15915	COG1609	Transcriptional regulator
HVY12_RS15920	COG3265	gluconokinase activity
HVY12_RS15925	COG2610	gluconate transmembrane transporter activity
HVY12_RS15930	COG2095	MarC family integral membrane protein
HVY12_RS15935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY12_RS15960	COG0058	SHG alpha-glucan phosphorylase activity
HVY12_RS15975	COG3188	usher protein
HVY12_RS15990	COG3121	Chaperone
HVY12_RS16000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY12_RS16015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY12_RS16030	COG1349	DNA-binding transcription factor activity
HVY12_RS16035	COG4650	regulator
HVY12_RS16040	COG1690	Belongs to the RtcB family
HVY12_RS16055	COG0058	SHG alpha-glucan phosphorylase activity
HVY12_RS16060	COG1640	4-alpha-glucanotransferase
HVY12_RS16065	COG2610	gluconate transmembrane transporter activity
HVY12_RS16095	COG5464	transposase or invertase
HVY12_RS16105	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVY12_RS16110	COG1918	ferrous iron import across plasma membrane
HVY12_RS16115	COG2183	response to ionizing radiation
HVY12_RS16120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY12_RS16125	COG0745	RESPONSE REGULATOR receiver
HVY12_RS16130	COG2205	protein histidine kinase activity
HVY12_RS16145	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY12_RS16150	COG4584	PFAM Integrase catalytic
HVY12_RS16155	COG1484	DNA-dependent DNA replication
HVY12_RS16165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVY12_RS16170	COG1011	Hydrolase
HVY12_RS16180	COG0494	nUDIX hydrolase
HVY12_RS16185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVY12_RS16190	COG4972	Pilus assembly protein
HVY12_RS16195	COG3166	PFAM Fimbrial assembly family protein
HVY12_RS16210	COG4796	Type ii and iii secretion system protein
HVY12_RS16225	COG3266	domain, Protein
HVY12_RS16230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVY12_RS16235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY12_RS16240	COG0546	phosphoglycolate phosphatase activity
HVY12_RS16245	COG0180	Tryptophanyl-tRNA synthetase
HVY12_RS16250	COG2188	Transcriptional regulator
HVY12_RS16260	COG3457	Alanine racemase
HVY12_RS16265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVY12_RS16270	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVY12_RS16285	COG0626	cystathionine gamma-synthase activity
HVY12_RS16300	COG2116	formate transmembrane transporter activity
HVY12_RS16305	COG2146	nitrite reductase [NAD(P)H] activity
HVY12_RS16310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY12_RS16320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY12_RS16330	COG2184	nucleotidyltransferase activity
HVY12_RS16335	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY12_RS16340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVY12_RS16345	COG1289	transmembrane transporter activity
HVY12_RS16350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY12_RS16355	COG1765	OsmC-like protein
HVY12_RS16360	COG3954	Phosphoribulokinase
HVY12_RS16370	COG0429	hydrolase of the alpha beta-hydrolase fold
HVY12_RS16375	COG0488	(ABC) transporter
HVY12_RS16390	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVY12_RS16395	COG1047	Peptidyl-prolyl cis-trans
HVY12_RS16405	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY12_RS16410	COG2964	Protein conserved in bacteria
HVY12_RS16480	COG0089	rRNA binding
HVY12_RS16570	COG0201	protein transport
HVY12_RS16600	COG0203	ribosomal protein L17
HVY12_RS16610	COG0789	Transcriptional regulator
HVY12_RS16615	COG3036	rescue of stalled ribosome
HVY12_RS16625	COG0569	domain protein
HVY12_RS16645	COG0758	DNA mediated transformation
HVY12_RS16655	COG0551	DNA topoisomerase type I activity
HVY12_RS16675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY12_RS16715	COG1126	abc transporter atp-binding protein
HVY12_RS16720	COG0765	amino acid transport
HVY12_RS16725	COG4597	amino acid ABC transporter
HVY12_RS16730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY12_RS16740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY12_RS16745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY12_RS16750	COG1309	transcriptional regulator
HVY12_RS16760	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVY12_RS16770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY12_RS16780	COG4145	pantothenate transmembrane transporter activity
HVY12_RS16785	COG3924	membrane
HVY12_RS16790	COG0439	Biotin carboxylase
HVY12_RS16795	COG0511	ligase activity, forming carbon-carbon bonds
HVY12_RS16810	COG0604	alcohol dehydrogenase
HVY12_RS16815	COG2199	diguanylate cyclase activity
HVY12_RS16815	COG2200	EAL domain
HVY12_RS16820	COG1077	Cell shape determining protein MreB Mrl
HVY12_RS16825	COG1792	Involved in formation and maintenance of cell shape
HVY12_RS16830	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVY12_RS16840	COG1530	ribonuclease E activity
HVY12_RS16845	COG3164	Protein of unknown function
HVY12_RS16850	COG0312	modulator of DNA gyrase
HVY12_RS16860	COG4584	PFAM Integrase catalytic
HVY12_RS16865	COG1484	DNA-dependent DNA replication
HVY12_RS16890	COG2732	(Barnase) inhibitor
HVY12_RS16910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY12_RS16915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY12_RS16920	COG3105	Protein conserved in bacteria
HVY12_RS16925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVY12_RS16940	COG0625	glutathione transferase activity
HVY12_RS16945	COG2969	positive regulation of protein catabolic process
HVY12_RS16960	COG2814	Major facilitator Superfamily
HVY12_RS16975	COG2731	YhcH YjgK YiaL family protein
HVY12_RS16990	COG3539	Fimbrial protein
HVY12_RS16995	COG3539	Fimbrial protein
HVY12_RS17000	COG3539	Fimbrial protein
HVY12_RS17005	COG3121	Chaperone
HVY12_RS17010	COG3188	usher protein
HVY12_RS17015	COG3539	Fimbrial protein
HVY12_RS17020	COG0493	'glutamate synthase
HVY12_RS17025	COG0067	glutamate synthase
HVY12_RS17025	COG0070	glutamate synthase
HVY12_RS17025	COG0069	glutamate synthase activity
HVY12_RS17030	COG1242	4 iron, 4 sulfur cluster binding
HVY12_RS17035	COG0784	Response regulator, receiver
HVY12_RS17035	COG2198	Histidine kinase
HVY12_RS17035	COG5002	protein histidine kinase activity
HVY12_RS17040	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVY12_RS17050	COG1484	DNA-dependent DNA replication
HVY12_RS17055	COG4584	PFAM Integrase catalytic
HVY12_RS17065	COG2885	chlorophyll binding
HVY12_RS17090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVY12_RS17095	COG4137	Cytochrome C assembly protein
HVY12_RS17100	COG4536	flavin adenine dinucleotide binding
HVY12_RS17115	COG0497	DNA recombination
HVY12_RS17120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY12_RS17130	COG2867	negative regulation of translational initiation
HVY12_RS17150	COG0579	oxidoreductase
HVY12_RS17155	COG1012	belongs to the aldehyde dehydrogenase family
HVY12_RS17160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY12_RS17165	COG1113	amino acid transport
HVY12_RS17170	COG1802	Transcriptional regulator
HVY12_RS17175	COG1652	LysM domain
HVY12_RS17180	COG0401	homolog of Blt101
HVY12_RS17185	COG0640	Transcriptional regulator
HVY12_RS17190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY12_RS17195	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVY12_RS17210	COG4575	ribosome binding
HVY12_RS17220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY12_RS17225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY12_RS17235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY12_RS17240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY12_RS17245	COG4175	Glycine betaine
HVY12_RS17250	COG4176	ABC-type proline glycine betaine transport system permease component
HVY12_RS17255	COG2113	Glycine betaine
HVY12_RS17260	COG2814	Major facilitator Superfamily
HVY12_RS17265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY12_RS17275	COG1846	Transcriptional regulator
HVY12_RS17280	COG1566	PFAM secretion protein HlyD family protein
HVY12_RS17285	COG2814	Major facilitator Superfamily
HVY12_RS17305	COG1238	metal cluster binding
HVY12_RS17310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY12_RS17340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVY12_RS17360	COG1546	Belongs to the CinA family
HVY12_RS17370	COG2951	lytic endotransglycosylase activity
HVY12_RS17375	COG3730	PTS system glucitol sorbitol-specific
HVY12_RS17380	COG3732	PTS system glucitol sorbitol-specific
HVY12_RS17390	COG1028	Short-chain dehydrogenase reductase Sdr
HVY12_RS17395	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS17400	COG1349	DNA-binding transcription factor activity
HVY12_RS17405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY12_RS17405	COG0517	IMP dehydrogenase activity
HVY12_RS17425	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVY12_RS17430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS17445	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY12_RS17455	COG3260	NADH ubiquinone oxidoreductase 20
HVY12_RS17460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY12_RS17465	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY12_RS17465	COG3261	NADH dehydrogenase
HVY12_RS17470	COG0650	Formate hydrogenlyase subunit 4
HVY12_RS17475	COG0651	ATP synthesis coupled electron transport
HVY12_RS17480	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS17490	COG0375	protein maturation
HVY12_RS17495	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVY12_RS17500	COG0298	carbon dioxide binding
HVY12_RS17505	COG0409	Hydrogenase expression formation protein
HVY12_RS17510	COG0309	Hydrogenase expression formation protein (HypE)
HVY12_RS17515	COG3604	Transcriptional regulator
HVY12_RS17545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY12_RS17550	COG1349	DNA-binding transcription factor activity
HVY12_RS17555	COG2084	Dehydrogenase
HVY12_RS17560	COG3395	kinase activity
HVY12_RS17565	COG0235	Class ii aldolase
HVY12_RS17570	COG3622	Belongs to the hyi family
HVY12_RS17575	COG2610	gluconate transmembrane transporter activity
HVY12_RS17585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY12_RS17590	COG1388	LysM domain
HVY12_RS17590	COG4942	peptidase
HVY12_RS17645	COG2234	aminopeptidase activity
HVY12_RS17660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY12_RS17670	COG0720	synthase
HVY12_RS17675	COG0644	oxidoreductase
HVY12_RS17680	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY12_RS17685	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HVY12_RS17690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVY12_RS17695	COG2086	electron transfer activity
HVY12_RS17700	COG0477	Major facilitator Superfamily
HVY12_RS17705	COG0277	FAD linked oxidase domain protein
HVY12_RS17710	COG1028	Short-chain dehydrogenase reductase Sdr
HVY12_RS17715	COG2223	nitrite transmembrane transporter activity
HVY12_RS17720	COG1070	Carbohydrate kinase
HVY12_RS17725	COG0602	queuosine metabolic process
HVY12_RS17735	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY12_RS17740	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY12_RS17755	COG3956	TIGRFAM MazG family protein
HVY12_RS17760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY12_RS17765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVY12_RS17770	COG4999	Histidine kinase
HVY12_RS17770	COG3437	response regulator, receiver
HVY12_RS17770	COG3850	Histidine kinase
HVY12_RS17770	COG2205	protein histidine kinase activity
HVY12_RS17775	COG0716	FMN binding
HVY12_RS17780	COG0564	pseudouridine synthase activity
HVY12_RS17785	COG3098	single-species biofilm formation
HVY12_RS17800	COG1611	Belongs to the LOG family
HVY12_RS17805	COG0814	amino acid
HVY12_RS17810	COG1760	l-serine dehydratase
HVY12_RS17820	COG1454	alcohol dehydrogenase
HVY12_RS17825	COG0235	Class ii aldolase
HVY12_RS17835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HVY12_RS17840	COG1609	Transcriptional regulator
HVY12_RS17845	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY12_RS17850	COG1129	ABC transporter
HVY12_RS17860	COG1070	Carbohydrate kinase
HVY12_RS17870	COG1349	DNA-binding transcription factor activity
HVY12_RS17880	COG2363	Small membrane protein
HVY12_RS17885	COG0583	DNA-binding transcription factor activity
HVY12_RS17895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVY12_RS17900	COG2166	iron-sulfur cluster assembly
HVY12_RS17905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVY12_RS17910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVY12_RS17930	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY12_RS17935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVY12_RS17935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVY12_RS17940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY12_RS17945	COG1074	ATP-dependent DNA helicase activity
HVY12_RS17955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVY12_RS17960	COG4967	type IV pilus modification protein PilV
HVY12_RS17970	COG4795	General secretion pathway protein
HVY12_RS17975	COG2165	general secretion pathway protein
HVY12_RS17990	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HVY12_RS18005	COG0861	Integral membrane protein TerC family
HVY12_RS18015	COG0667	Aldo Keto reductase
HVY12_RS18035	COG1609	Transcriptional regulator
HVY12_RS18045	COG0583	DNA-binding transcription factor activity
HVY12_RS18050	COG1794	racemase activity, acting on amino acids and derivatives
HVY12_RS18055	COG2814	Major facilitator Superfamily
HVY12_RS18060	COG1028	Short-chain dehydrogenase reductase Sdr
HVY12_RS18070	COG0183	Belongs to the thiolase family
HVY12_RS18075	COG0814	amino acid
HVY12_RS18080	COG2771	luxR family
HVY12_RS18085	COG3710	Transcriptional regulator
HVY12_RS18095	COG0457	Tetratricopeptide repeat
HVY12_RS18095	COG3710	Transcriptional regulator
HVY12_RS18180	COG0582	viral genome integration into host DNA
HVY12_RS18190	COG4942	peptidase
HVY12_RS18195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVY12_RS18200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVY12_RS18205	COG2080	2 iron, 2 sulfur cluster binding
HVY12_RS18215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVY12_RS18220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY12_RS18225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY12_RS18235	COG0549	Belongs to the carbamate kinase family
HVY12_RS18240	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVY12_RS18240	COG3608	succinylglutamate desuccinylase aspartoacylase
HVY12_RS18245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY12_RS18250	COG2068	MobA-Related Protein
HVY12_RS18255	COG0493	'glutamate synthase
HVY12_RS18255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS18260	COG0402	S-adenosylhomocysteine deaminase activity
HVY12_RS18265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVY12_RS18270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVY12_RS18270	COG2080	2 iron, 2 sulfur cluster binding
HVY12_RS18275	COG2233	PERMEase
HVY12_RS18280	COG0402	S-adenosylhomocysteine deaminase activity
HVY12_RS18285	COG2252	PERMEase
HVY12_RS18290	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS18300	COG2233	PERMEase
HVY12_RS18310	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HVY12_RS18315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVY12_RS18325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVY12_RS18330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY12_RS18335	COG4974	Belongs to the 'phage' integrase family
HVY12_RS18340	COG0716	FMN binding
HVY12_RS18350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVY12_RS18360	COG1272	protein, Hemolysin III
HVY12_RS18370	COG2723	6-phospho-beta-galactosidase activity
HVY12_RS18395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY12_RS18400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY12_RS18405	COG0006	proline dipeptidase activity
HVY12_RS18425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVY12_RS18430	COG1454	alcohol dehydrogenase
HVY12_RS18435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS18450	COG3775	system Galactitol-specific IIC component
HVY12_RS18455	COG3414	Phosphotransferase system galactitol-specific IIB component
HVY12_RS18470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY12_RS18485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY12_RS18485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY12_RS18490	COG1703	isobutyryl-CoA mutase activity
HVY12_RS18495	COG1024	Enoyl-CoA hydratase
HVY12_RS18500	COG0427	acetyl-CoA hydrolase
HVY12_RS18505	COG0583	DNA-binding transcription factor activity
HVY12_RS18510	COG2968	Membrane
HVY12_RS18515	COG1279	arginine transmembrane transporter activity
HVY12_RS18530	COG0668	transmembrane transport
HVY12_RS18535	COG0191	fructose-bisphosphate aldolase activity
HVY12_RS18565	COG1122	ATPase activity
HVY12_RS18575	COG1072	(Pantothenic acid kinase))
HVY12_RS18585	COG1494	fructose-1,6-bisphosphatase
HVY12_RS18590	COG1063	alcohol dehydrogenase
HVY12_RS18595	COG2213	PTS system mannitol-specific
HVY12_RS18600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS18605	COG0330	HflC and HflK could
HVY12_RS18610	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY12_RS18615	COG0501	Belongs to the peptidase M48B family
HVY12_RS18630	COG1166	arginine decarboxylase activity
HVY12_RS18650	COG2814	Major facilitator Superfamily
HVY12_RS18660	COG2356	endonuclease I
HVY12_RS18665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVY12_RS18670	COG0189	ligase activity
HVY12_RS18685	COG2805	Type II/IV secretion system protein
HVY12_RS18690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVY12_RS18695	COG0762	integral membrane protein
HVY12_RS18710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY12_RS18720	COG0252	asparaginase activity
HVY12_RS18730	COG3171	Protein conserved in bacteria
HVY12_RS18740	COG1194	a g-specific adenine glycosylase
HVY12_RS18755	COG2211	Major facilitator Superfamily
HVY12_RS18760	COG1982	Orn Lys Arg decarboxylase major
HVY12_RS18765	COG1811	Na channel or pump
HVY12_RS18775	COG0582	viral genome integration into host DNA
HVY12_RS18790	COG4584	PFAM Integrase catalytic
HVY12_RS18795	COG1484	DNA-dependent DNA replication
HVY12_RS18870	COG1484	DNA-dependent DNA replication
HVY12_RS18875	COG4584	PFAM Integrase catalytic
HVY12_RS18925	COG1475	DNA binding
HVY12_RS18930	COG3969	phosphoadenosine phosphosulfate
HVY12_RS19035	COG2885	chlorophyll binding
HVY12_RS19090	COG4795	General secretion pathway protein
HVY12_RS19105	COG2165	general secretion pathway protein
HVY12_RS19110	COG1459	type II secretion system
HVY12_RS19115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY12_RS19150	COG2200	EAL domain
HVY12_RS19265	COG3596	GTP binding
HVY12_RS19270	COG2378	regulation of single-species biofilm formation
HVY12_RS19300	COG2003	Belongs to the UPF0758 family
HVY12_RS19340	COG3609	addiction module antidote protein, CC2985 family
HVY12_RS19350	COG4584	PFAM Integrase catalytic
HVY12_RS19355	COG1484	DNA-dependent DNA replication
HVY12_RS19360	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HVY12_RS19375	COG4795	General secretion pathway protein
HVY12_RS19380	COG2165	general secretion pathway protein
HVY12_RS19390	COG2165	general secretion pathway protein
HVY12_RS19395	COG1459	type II secretion system
HVY12_RS19400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY12_RS19410	COG3031	protein transport across the cell outer membrane
HVY12_RS19420	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HVY12_RS19425	COG3064	Membrane
HVY12_RS19430	COG1620	l-lactate permease
HVY12_RS19435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY12_RS19440	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HVY12_RS19445	COG0247	lactate metabolic process
HVY12_RS19450	COG0277	FAD linked oxidase domain protein
HVY12_RS19455	COG0277	FAD linked oxidase domain protein
HVY12_RS19460	COG2186	Transcriptional regulator
HVY12_RS19465	COG0456	acetyltransferase
HVY12_RS19470	COG0318	PFAM AMP-dependent synthetase and ligase
HVY12_RS19480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVY12_RS19485	COG0156	8-amino-7-oxononanoate synthase activity
HVY12_RS19495	COG0795	lipopolysaccharide-transporting ATPase activity
HVY12_RS19500	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY12_RS19510	COG2244	polysaccharide biosynthetic process
HVY12_RS19515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVY12_RS19520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVY12_RS19525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVY12_RS19530	COG0306	phosphate transporter
HVY12_RS19535	COG0754	glutathionylspermidine amidase activity
HVY12_RS19540	COG0625	glutathione transferase activity
HVY12_RS19545	COG0298	carbon dioxide binding
HVY12_RS19555	COG1773	rubredoxin
HVY12_RS19560	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY12_RS19565	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY12_RS19570	COG5557	Pfam Polysulphide reductase, NrfD
HVY12_RS19575	COG0437	4 iron, 4 sulfur cluster binding
HVY12_RS19580	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY12_RS19595	COG0667	Aldo Keto reductase
HVY12_RS19610	COG0848	biopolymer transport protein
HVY12_RS19615	COG0811	peptide transport
HVY12_RS19620	COG0626	cystathionine gamma-synthase activity
HVY12_RS19625	COG0586	Pfam SNARE associated Golgi protein
HVY12_RS19630	COG2207	Transcriptional regulator
HVY12_RS19635	COG1979	alcohol dehydrogenase
HVY12_RS19640	COG0656	L-ascorbic acid biosynthetic process
HVY12_RS19650	COG4238	major outer membrane lipoprotein
HVY12_RS19655	COG1032	radical SAM domain protein
HVY12_RS19660	COG2132	Multicopper oxidase
HVY12_RS19665	COG0204	Acyl-transferase
HVY12_RS19670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY12_RS19675	COG4166	transmembrane transport
HVY12_RS19680	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY12_RS19685	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY12_RS19690	COG0745	RESPONSE REGULATOR receiver
HVY12_RS19695	COG0642	Histidine kinase
HVY12_RS19700	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVY12_RS19705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVY12_RS19710	COG1737	Transcriptional regulator
HVY12_RS19720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY12_RS19725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY12_RS19730	COG1120	ATPase activity
HVY12_RS19735	COG4774	siderophore transport
HVY12_RS19740	COG0187	DNA topoisomerase II activity
HVY12_RS19745	COG3150	esterase
HVY12_RS19750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVY12_RS19755	COG3151	Protein conserved in bacteria
HVY12_RS19760	COG0494	nUDIX hydrolase
HVY12_RS19765	COG1538	Outer membrane efflux protein
HVY12_RS19775	COG0754	glutathionylspermidine amidase activity
HVY12_RS19785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HVY12_RS19795	COG3384	dioxygenase
HVY12_RS19820	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY12_RS19825	COG2268	Band 7 protein
HVY12_RS19845	COG3025	triphosphatase activity
HVY12_RS19850	COG4991	sh3 domain protein
HVY12_RS19865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY12_RS19880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVY12_RS19885	COG0358	DNA primase activity
HVY12_RS19890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY12_RS19905	COG2375	cellular response to nickel ion
HVY12_RS19910	COG1695	Transcriptional regulator
HVY12_RS19915	COG0840	transmembrane signaling receptor activity
HVY12_RS19925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVY12_RS19930	COG1609	Transcriptional regulator
HVY12_RS19935	COG3250	beta-galactosidase activity
HVY12_RS19940	COG2731	YhcH YjgK YiaL family protein
HVY12_RS19945	COG0531	amino acid
HVY12_RS19955	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HVY12_RS19955	COG3408	Glycogen debranching enzyme
HVY12_RS19960	COG1902	pentaerythritol trinitrate reductase activity
HVY12_RS19960	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVY12_RS19970	COG1451	nucleotide metabolic process
HVY12_RS19975	COG2949	membrane
HVY12_RS19980	COG0673	inositol 2-dehydrogenase activity
HVY12_RS19985	COG0861	Integral membrane protein TerC family
HVY12_RS19990	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVY12_RS20000	COG2721	sulfolactate sulfo-lyase activity
HVY12_RS20010	COG2271	Major facilitator Superfamily
HVY12_RS20015	COG2186	Transcriptional regulator
HVY12_RS20020	COG0586	Pfam SNARE associated Golgi protein
HVY12_RS20030	COG1422	Protein of unknown function (DUF1090)
HVY12_RS20035	COG4575	ribosome binding
HVY12_RS20040	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVY12_RS20050	COG2259	Doxx family
HVY12_RS20055	COG0435	Glutathione S-transferase
HVY12_RS20060	COG3152	Membrane
HVY12_RS20065	COG0583	DNA-binding transcription factor activity
HVY12_RS20070	COG1741	Belongs to the pirin family
HVY12_RS20085	COG0814	amino acid
HVY12_RS20090	COG1760	l-serine dehydratase
HVY12_RS20095	COG0251	oxidation-reduction process
HVY12_RS20100	COG1882	Formate acetyltransferase
HVY12_RS20105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVY12_RS20115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY12_RS20120	COG0583	DNA-binding transcription factor activity
HVY12_RS20130	COG1929	Belongs to the glycerate kinase type-1 family
HVY12_RS20135	COG2084	Dehydrogenase
HVY12_RS20140	COG3836	Belongs to the HpcH HpaI aldolase family
HVY12_RS20145	COG2271	Major facilitator Superfamily
HVY12_RS20150	COG2721	sulfolactate sulfo-lyase activity
HVY12_RS20155	COG1349	DNA-binding transcription factor activity
HVY12_RS20165	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY12_RS20175	COG3716	PTS system mannose fructose sorbose family IID component
HVY12_RS20180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS20190	COG2222	sugar isomerase
HVY12_RS20200	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY12_RS20205	COG3715	PTS system
HVY12_RS20210	COG3716	PTS system mannose fructose sorbose family IID component
HVY12_RS20215	COG0363	glucosamine-6-phosphate deaminase activity
HVY12_RS20220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVY12_RS20225	COG3107	peptidoglycan biosynthetic process
HVY12_RS20240	COG2823	Periplasmic or secreted lipoprotein
HVY12_RS20245	COG0701	Predicted permease
HVY12_RS20250	COG0702	epimerase
HVY12_RS20265	COG3153	acetyltransferase
HVY12_RS20270	COG3154	lipid carrier protein
HVY12_RS20275	COG0826	peptidase U32
HVY12_RS20280	COG0826	peptidase U32
HVY12_RS20285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY12_RS20290	COG0814	amino acid
HVY12_RS20295	COG0513	Belongs to the DEAD box helicase family
HVY12_RS20335	COG0195	Participates in both transcription termination and antitermination
HVY12_RS20365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY12_RS20375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVY12_RS20380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVY12_RS20390	COG1534	Rna-binding protein
HVY12_RS20395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY12_RS20400	COG2027	D-alanyl-D-alanine carboxypeptidase
HVY12_RS20410	COG0697	spore germination
HVY12_RS20425	COG0142	geranyltranstransferase activity
HVY12_RS20430	COG3423	Transcriptional regulator
HVY12_RS20440	COG5007	Belongs to the BolA IbaG family
HVY12_RS20445	COG3113	response to antibiotic
HVY12_RS20450	COG2854	intermembrane phospholipid transfer
HVY12_RS20455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY12_RS20460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVY12_RS20465	COG1127	ABC transporter
HVY12_RS20470	COG0530	calcium, potassium:sodium antiporter activity
HVY12_RS20475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY12_RS20475	COG0517	IMP dehydrogenase activity
HVY12_RS20480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVY12_RS20485	COG3117	lipopolysaccharide transmembrane transporter activity
HVY12_RS20490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVY12_RS20495	COG1137	ATPase activity
HVY12_RS20500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVY12_RS20505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY12_RS20520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS20525	COG0515	serine threonine protein kinase
HVY12_RS20535	COG4584	PFAM Integrase catalytic
HVY12_RS20540	COG1484	DNA-dependent DNA replication
HVY12_RS20560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY12_RS20565	COG1605	Chorismate mutase
HVY12_RS20565	COG0287	Prephenate dehydrogenase
HVY12_RS20570	COG0077	Prephenate dehydratase
HVY12_RS20570	COG1605	Chorismate mutase
HVY12_RS20580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY12_RS20585	COG3385	transposase activity
HVY12_RS20590	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY12_RS20595	COG0564	pseudouridine synthase activity
HVY12_RS20605	COG0542	response to heat
HVY12_RS20630	COG0477	Major facilitator Superfamily
HVY12_RS20635	COG5544	Lipoprotein
HVY12_RS20640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY12_RS20645	COG0045	succinate-CoA ligase (ADP-forming) activity
HVY12_RS20645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY12_RS20645	COG1042	CoA-binding domain protein
HVY12_RS20655	COG3118	belongs to the thioredoxin family
HVY12_RS20660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY12_RS20675	COG0513	Belongs to the DEAD box helicase family
HVY12_RS20685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY12_RS20695	COG1595	DNA-templated transcription, initiation
HVY12_RS20700	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVY12_RS20705	COG3026	antisigma factor binding
HVY12_RS20710	COG3086	response to oxidative stress
HVY12_RS20720	COG0681	Belongs to the peptidase S26 family
HVY12_RS20740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVY12_RS20750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS20755	COG1737	Transcriptional regulator
HVY12_RS20760	COG0560	Phosphoserine phosphatase
HVY12_RS20775	COG0047	phosphoribosylformylglycinamidine synthase activity
HVY12_RS20775	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVY12_RS20780	COG2205	protein histidine kinase activity
HVY12_RS20785	COG3170	Tfp pilus assembly protein FimV
HVY12_RS20790	COG2204	response regulator
HVY12_RS20795	COG0347	Belongs to the P(II) protein family
HVY12_RS20800	COG1017	nitric oxide dioxygenase activity
HVY12_RS20800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY12_RS20810	COG1940	carbohydrate kinase activity
HVY12_RS20815	COG0457	Tetratricopeptide repeat
HVY12_RS20820	COG1879	ABC-type sugar transport system periplasmic component
HVY12_RS20825	COG1129	ABC transporter
HVY12_RS20830	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY12_RS20835	COG1063	alcohol dehydrogenase
HVY12_RS20840	COG2017	converts alpha-aldose to the beta-anomer
HVY12_RS20845	COG2259	Doxx family
HVY12_RS20850	COG2814	Major facilitator Superfamily
HVY12_RS20855	COG3711	transcriptional antiterminator
HVY12_RS20860	COG1073	alpha beta
HVY12_RS20865	COG0483	inositol monophosphate 1-phosphatase activity
HVY12_RS20885	COG0822	iron-sulfur transferase activity
HVY12_RS20905	COG0633	Ferredoxin
HVY12_RS20910	COG2975	iron-sulfur cluster assembly
HVY12_RS20925	COG2897	thiosulfate sulfurtransferase activity
HVY12_RS20930	COG2373	Large extracellular alpha-helical protein
HVY12_RS20935	COG4953	penicillin-binding protein 1C
HVY12_RS20965	COG2976	Protein conserved in bacteria
HVY12_RS20980	COG1645	bacterial-type flagellum-dependent swarming motility
HVY12_RS20990	COG0516	GMP reductase activity
HVY12_RS20990	COG0517	IMP dehydrogenase activity
HVY12_RS21005	COG3133	Outer membrane lipoprotein
HVY12_RS21020	COG2200	EAL domain
HVY12_RS21025	COG0248	Ppx GppA phosphatase
HVY12_RS21030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HVY12_RS21035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVY12_RS21050	COG2233	PERMEase
HVY12_RS21060	COG1393	Belongs to the ArsC family
HVY12_RS21065	COG4783	chaperone-mediated protein folding
HVY12_RS21070	COG0628	permease
HVY12_RS21075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVY12_RS21080	COG2716	regulation of RNA biosynthetic process
HVY12_RS21090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVY12_RS21100	COG2321	neutral zinc metallopeptidase
HVY12_RS21105	COG1444	tRNA N-acetyltransferase activity
HVY12_RS21110	COG0400	carboxylic ester hydrolase activity
HVY12_RS21125	COG1393	Belongs to the ArsC family
HVY12_RS21135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY12_RS21145	COG3850	Histidine kinase
HVY12_RS21150	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS21150	COG0493	'glutamate synthase
HVY12_RS21160	COG5342	invasion associated locus B
HVY12_RS21165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY12_RS21170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY12_RS21175	COG0281	malic enzyme
HVY12_RS21175	COG0280	phosphate acetyltransferase
HVY12_RS21180	COG4810	utilization protein
HVY12_RS21185	COG4917	ethanolamine utilization protein
HVY12_RS21190	COG4766	ethanolamine catabolic process
HVY12_RS21195	COG4812	Cobalamin adenosyltransferase
HVY12_RS21200	COG0280	phosphate acetyltransferase
HVY12_RS21205	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVY12_RS21210	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HVY12_RS21215	COG1012	belongs to the aldehyde dehydrogenase family
HVY12_RS21220	COG4820	ethanolamine utilization protein (EutJ)
HVY12_RS21225	COG1454	alcohol dehydrogenase
HVY12_RS21230	COG3192	ethanolamine utilization protein
HVY12_RS21235	COG4819	ethanolamine utilization protein
HVY12_RS21240	COG4303	Ethanolamine ammonia lyase large subunit
HVY12_RS21250	COG4816	utilization protein
HVY12_RS21255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVY12_RS21260	COG2207	Transcriptional regulator
HVY12_RS21270	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY12_RS21290	COG2837	iron assimilation
HVY12_RS21300	COG1028	Short-chain dehydrogenase reductase Sdr
HVY12_RS21305	COG4150	thiosulfate binding
HVY12_RS21310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVY12_RS21315	COG4208	sulfate ABC transporter
HVY12_RS21320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVY12_RS21325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY12_RS21330	COG3831	ATPase activity
HVY12_RS21330	COG4884	unkown
HVY12_RS21345	COG2190	(PTS) system
HVY12_RS21350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY12_RS21355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS21360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY12_RS21380	COG3530	Putative quorum-sensing-regulated virulence factor
HVY12_RS21385	COG0385	Bile acid
HVY12_RS21390	COG0583	DNA-binding transcription factor activity
HVY12_RS21400	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVY12_RS21405	COG2211	Major facilitator Superfamily
HVY12_RS21415	COG0583	DNA-binding transcription factor activity
HVY12_RS21445	COG3415	Transposase
HVY12_RS21450	COG3415	Transposase
HVY12_RS21465	COG2200	EAL domain
HVY12_RS21465	COG2199	diguanylate cyclase activity
HVY12_RS21470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY12_RS21495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY12_RS21500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY12_RS21505	COG0006	proline dipeptidase activity
HVY12_RS21510	COG1363	Peptidase, m42
HVY12_RS21520	COG2207	Transcriptional regulator
HVY12_RS21525	COG3279	Response regulator of the LytR AlgR family
HVY12_RS21530	COG3275	phosphorelay sensor kinase activity
HVY12_RS21535	COG0436	Aminotransferase
HVY12_RS21545	COG1560	Kdo2-lipid A biosynthetic process
HVY12_RS21555	COG4584	PFAM Integrase catalytic
HVY12_RS21560	COG1484	DNA-dependent DNA replication
HVY12_RS21625	COG2116	formate transmembrane transporter activity
HVY12_RS21635	COG2067	long-chain fatty acid transport protein
HVY12_RS21640	COG3691	Protein conserved in bacteria
HVY12_RS21650	COG1024	Enoyl-CoA hydratase
HVY12_RS21650	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY12_RS21655	COG2062	phosphohistidine phosphatase, SixA
HVY12_RS21680	COG0730	response to heat
HVY12_RS21685	COG3101	peptidyl-lysine hydroxylation
HVY12_RS21700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY12_RS21705	COG2814	Major facilitator Superfamily
HVY12_RS21720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY12_RS21730	COG0586	Pfam SNARE associated Golgi protein
HVY12_RS21740	COG0285	dihydrofolate synthase activity
HVY12_RS21745	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVY12_RS21750	COG1286	toxin biosynthetic process
HVY12_RS21755	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVY12_RS21760	COG0163	prenyltransferase activity
HVY12_RS21765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY12_RS21770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY12_RS21775	COG4215	(ABC) transporter
HVY12_RS21780	COG4160	amino acid transport
HVY12_RS21785	COG4598	ABC transporter
HVY12_RS21790	COG5464	transposase or invertase
HVY12_RS21795	COG1090	epimerase
HVY12_RS21800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY12_RS21805	COG0625	glutathione transferase activity
HVY12_RS21810	COG0625	glutathione transferase activity
HVY12_RS21815	COG0622	Phosphoesterase
HVY12_RS21820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HVY12_RS21825	COG1609	Transcriptional regulator
HVY12_RS21840	COG3037	sugar-specific permease SgaT UlaA
HVY12_RS21845	COG3959	Transketolase, thiamine diphosphate binding domain
HVY12_RS21850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVY12_RS21855	COG1288	antiporter activity
HVY12_RS21860	COG0857	belongs to the CobB CobQ family
HVY12_RS21860	COG0280	phosphate acetyltransferase
HVY12_RS21865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVY12_RS21880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY12_RS21885	COG0490	domain, Protein
HVY12_RS21885	COG0471	metal ion transport
HVY12_RS21895	COG0436	Aminotransferase
HVY12_RS21900	COG0583	DNA-binding transcription factor activity
HVY12_RS21920	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVY12_RS21925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVY12_RS21930	COG1034	ATP synthesis coupled electron transport
HVY12_RS21945	COG0839	Belongs to the complex I subunit 6 family
HVY12_RS21955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY12_RS21960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY12_RS21975	COG2234	aminopeptidase activity
HVY12_RS21980	COG2304	oxidoreductase activity
HVY12_RS21990	COG2153	protein acetylation
HVY12_RS21995	COG4575	ribosome binding
HVY12_RS22000	COG1169	isochorismate synthase
HVY12_RS22015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVY12_RS22025	COG0318	PFAM AMP-dependent synthetase and ligase
HVY12_RS22090	COG1414	Transcriptional regulator
HVY12_RS22100	COG2271	Major facilitator Superfamily
HVY12_RS22115	COG5464	transposase or invertase
HVY12_RS22120	COG0247	lactate metabolic process
HVY12_RS22130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY12_RS22135	COG2271	Major facilitator Superfamily
HVY12_RS22140	COG0584	glycerophosphoryl diester phosphodiesterase
HVY12_RS22145	COG3642	lipopolysaccharide core region biosynthetic process
HVY12_RS22150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY12_RS22155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY12_RS22160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY12_RS22165	COG3468	outer membrane autotransporter barrel domain protein
HVY12_RS22175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY12_RS22180	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HVY12_RS22185	COG3234	Protein of unknown function (DUF1175)
HVY12_RS22190	COG2373	Large extracellular alpha-helical protein
HVY12_RS22195	COG5445	Predicted secreted protein (DUF2300)
HVY12_RS22200	COG4676	Protein conserved in bacteria
HVY12_RS22205	COG0183	Belongs to the thiolase family
HVY12_RS22210	COG2031	fatty acid transporter
HVY12_RS22215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY12_RS22220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVY12_RS22225	COG2204	response regulator
HVY12_RS22230	COG3852	Histidine kinase
HVY12_RS22235	COG0784	Response regulator, receiver
HVY12_RS22235	COG2205	protein histidine kinase activity
HVY12_RS22240	COG2197	response regulator
HVY12_RS22245	COG2198	Histidine kinase
HVY12_RS22245	COG0642	Histidine kinase
HVY12_RS22250	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY12_RS22255	COG1477	protein flavinylation
HVY12_RS22260	COG2169	Transcriptional regulator
HVY12_RS22260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY12_RS22265	COG3145	DNA-N1-methyladenine dioxygenase activity
HVY12_RS22270	COG4615	Cyclic peptide transporter
HVY12_RS22285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS22285	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY12_RS22290	COG3062	negative regulation of establishment of protein localization
HVY12_RS22300	COG0437	4 iron, 4 sulfur cluster binding
HVY12_RS22305	COG0348	domain, Protein
HVY12_RS22310	COG3043	anaerobic respiration
HVY12_RS22315	COG3005	denitrification pathway
HVY12_RS22320	COG4133	protoheme IX ABC transporter activity
HVY12_RS22325	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY12_RS22330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY12_RS22335	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY12_RS22345	COG1138	Cytochrome C-type biogenesis protein
HVY12_RS22350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY12_RS22355	COG3088	subunit of a heme lyase
HVY12_RS22355	COG4235	cytochrome complex assembly
HVY12_RS22360	COG2197	response regulator
HVY12_RS22370	COG3083	sulfuric ester hydrolase activity
HVY12_RS22390	COG1061	Type III restriction enzyme res subunit
HVY12_RS22395	COG1187	pseudouridine synthase activity
HVY12_RS22400	COG2814	Major facilitator Superfamily
HVY12_RS22410	COG4172	Belongs to the ABC transporter superfamily
HVY12_RS22415	COG4239	(ABC) transporter, permease
HVY12_RS22420	COG4174	ABC transporter (Permease)
HVY12_RS22425	COG4166	transmembrane transport
HVY12_RS22430	COG2200	EAL domain
HVY12_RS22435	COG0791	NLP P60 protein
HVY12_RS22440	COG0671	phosphoesterase, PA-phosphatase related
HVY12_RS22445	COG0523	cobalamin synthesis protein
HVY12_RS22450	COG0246	Mannitol dehydrogenase
HVY12_RS22465	COG2814	Major facilitator Superfamily
HVY12_RS22470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS22470	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY12_RS22475	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY12_RS22480	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVY12_RS22480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY12_RS22480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY12_RS22485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY12_RS22490	COG2313	pseudouridylate synthase activity
HVY12_RS22495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY12_RS22500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY12_RS22510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY12_RS22515	COG1522	sequence-specific DNA binding
HVY12_RS22515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY12_RS22525	COG2855	membrane
HVY12_RS22530	COG0583	DNA-binding transcription factor activity
HVY12_RS22535	COG0833	amino acid
HVY12_RS22540	COG4771	TonB-dependent receptor
HVY12_RS22555	COG2311	Membrane
HVY12_RS22560	COG1609	Transcriptional regulator
HVY12_RS22565	COG1879	ABC-type sugar transport system periplasmic component
HVY12_RS22570	COG1129	ABC transporter
HVY12_RS22575	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVY12_RS22580	COG0167	dihydroorotate dehydrogenase activity
HVY12_RS22580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVY12_RS22585	COG0493	'glutamate synthase
HVY12_RS22595	COG2949	membrane
HVY12_RS22605	COG1346	cytolysis
HVY12_RS22615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY12_RS22630	COG0586	Pfam SNARE associated Golgi protein
HVY12_RS22640	COG1686	Belongs to the peptidase S11 family
HVY12_RS22645	COG0277	FAD linked oxidase domain protein
HVY12_RS22650	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY12_RS22655	COG1732	Glycine betaine
HVY12_RS22660	COG1174	glycine betaine transport
HVY12_RS22665	COG1125	glycine betaine transport
HVY12_RS22670	COG1174	glycine betaine transport
HVY12_RS22680	COG0789	Transcriptional regulator
HVY12_RS22685	COG3275	phosphorelay sensor kinase activity
HVY12_RS22690	COG3279	Response regulator of the LytR AlgR family
HVY12_RS22695	COG4807	Protein conserved in bacteria
HVY12_RS22700	COG4808	Protein conserved in bacteria
HVY12_RS22705	COG4715	Zinc finger, swim domain protein
HVY12_RS22710	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVY12_RS22715	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVY12_RS22720	COG0714	Associated with various cellular activities
HVY12_RS22730	COG3831	ATPase activity
HVY12_RS22735	COG3831	ATPase activity
HVY12_RS22740	COG3831	ATPase activity
HVY12_RS22745	COG3831	ATPase activity
HVY12_RS22755	COG0489	protein tyrosine kinase activity
HVY12_RS22765	COG3539	Fimbrial protein
HVY12_RS22770	COG3121	Chaperone
HVY12_RS22775	COG3188	usher protein
HVY12_RS22780	COG3539	Fimbrial protein
HVY12_RS22785	COG5455	response to cobalt ion
HVY12_RS22790	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HVY12_RS22805	COG0351	phosphomethylpyrimidine kinase
HVY12_RS22810	COG3757	hydrolase, family 25
HVY12_RS22815	COG2188	Transcriptional regulator
HVY12_RS22820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY12_RS22825	COG1397	ADP-ribosylglycohydrolase
HVY12_RS22830	COG2211	Major facilitator Superfamily
HVY12_RS22835	COG1830	Aldolase
HVY12_RS22845	COG4974	Belongs to the 'phage' integrase family
HVY12_RS22930	COG2207	Transcriptional regulator
HVY12_RS22930	COG3708	Transcriptional regulator
HVY12_RS22945	COG2801	Transposase and inactivated derivatives
HVY12_RS22945	COG3415	Transposase
HVY12_RS23015	COG2200	EAL domain
HVY12_RS23050	COG3547	Transposase (IS116 IS110 IS902 family)
HVY12_RS23060	COG4584	PFAM Integrase catalytic
HVY12_RS23065	COG1484	DNA-dependent DNA replication
HVY12_RS23085	COG2207	Transcriptional regulator
HVY12_RS23090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY12_RS23395	COG4584	PFAM Integrase catalytic
HVY12_RS23400	COG1484	DNA-dependent DNA replication
HVY12_RS23440	COG2805	Type II/IV secretion system protein
HVY12_RS23490	COG0741	lytic transglycosylase activity
HVY12_RS23505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY12_RS23575	COG2205	protein histidine kinase activity
HVY12_RS23580	COG0745	RESPONSE REGULATOR receiver
HVY12_RS23585	COG2351	hydroxyisourate hydrolase activity
HVY12_RS23650	COG1484	DNA-dependent DNA replication
HVY12_RS23655	COG4584	PFAM Integrase catalytic
HVY12_RS23660	COG3710	Transcriptional regulator
HVY12_RS23755	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HVY12_RS23865	COG4584	PFAM Integrase catalytic
HVY12_RS23870	COG1484	DNA-dependent DNA replication
HVY12_RS24035	COG3547	Transposase (IS116 IS110 IS902 family)