locus-tag	class	description
CN246_RS00010	COG0592	DNA-directed DNA polymerase activity
CN246_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CN246_RS00030	COG0187	DNA topoisomerase II activity
CN246_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CN246_RS00060	COG2814	Major facilitator Superfamily
CN246_RS00065	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CN246_RS00070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CN246_RS00085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CN246_RS00090	COG0543	2 iron, 2 sulfur cluster binding
CN246_RS00095	COG0167	dihydroorotate dehydrogenase activity
CN246_RS00105	COG0588	phosphoglycerate mutase activity
CN246_RS00110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CN246_RS00120	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CN246_RS00125	COG0217	transcriptional regulatory protein
CN246_RS00135	COG0306	phosphate transporter
CN246_RS00145	COG0351	phosphomethylpyrimidine kinase
CN246_RS00145	COG0352	thiamine-phosphate diphosphorylase activity
CN246_RS00170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CN246_RS00190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CN246_RS00205	COG0157	Belongs to the NadC ModD family
CN246_RS00220	COG3300	MHYT domain
CN246_RS00220	COG5001	Diguanylate cyclase
CN246_RS00225	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CN246_RS00235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CN246_RS00245	COG1027	Aspartate ammonia-lyase
CN246_RS00250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CN246_RS00295	COG0577	efflux transmembrane transporter activity
CN246_RS00300	COG1136	(ABC) transporter
CN246_RS00315	COG1597	lipid kinase activity
CN246_RS00320	COG1032	radical SAM domain protein
CN246_RS00325	COG0740	serine-type endopeptidase activity
CN246_RS00345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CN246_RS00350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CN246_RS00370	COG1396	sequence-specific DNA binding
CN246_RS00385	COG1484	DNA-dependent DNA replication
CN246_RS00605	COG4251	negative regulation of phosphorylation
CN246_RS00605	COG5001	Diguanylate cyclase
CN246_RS00605	COG2203	Gaf domain
CN246_RS00605	COG3706	GGDEF domain
CN246_RS00615	COG1132	(ABC) transporter
CN246_RS00640	COG0463	Glycosyl transferase, family 2
CN246_RS00640	COG0457	Tetratricopeptide repeat
CN246_RS00645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CN246_RS00655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CN246_RS00660	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN246_RS00685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CN246_RS00710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CN246_RS00720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CN246_RS00740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CN246_RS00745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CN246_RS00750	COG0778	Nitroreductase
CN246_RS00755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CN246_RS00760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CN246_RS00765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CN246_RS00770	COG0165	Argininosuccinate lyase
CN246_RS00775	COG0137	argininosuccinate synthase activity
CN246_RS00795	COG0129	dihydroxy-acid dehydratase activity
CN246_RS00800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CN246_RS00805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CN246_RS00815	COG2177	Part of the ABC transporter FtsEX involved in
CN246_RS00820	COG2884	Cell division ATP-binding protein ftsE
CN246_RS00825	COG3835	regulator
CN246_RS00830	COG1187	pseudouridine synthase activity
CN246_RS00865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CN246_RS00870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CN246_RS00875	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CN246_RS00880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CN246_RS00895	COG3579	cysteine-type endopeptidase activity
CN246_RS00905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CN246_RS00910	COG0531	amino acid
CN246_RS00915	COG1668	transmembrane transport
CN246_RS00920	COG4152	abc transporter atp-binding protein
CN246_RS00950	COG0028	Belongs to the TPP enzyme family
CN246_RS00955	COG0440	acetolactate synthase activity
CN246_RS00960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CN246_RS00965	COG0735	belongs to the Fur family
CN246_RS00985	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CN246_RS00990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CN246_RS00995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CN246_RS01000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CN246_RS01005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CN246_RS01010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CN246_RS01030	COG0138	bifunctional purine biosynthesis protein purh
CN246_RS01035	COG0151	Belongs to the GarS family
CN246_RS01050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CN246_RS01055	COG1461	Dihydroxyacetone kinase
CN246_RS01060	COG1302	Protein conserved in bacteria
CN246_RS01070	COG2359	stage V sporulation protein S
CN246_RS01075	COG1692	metallophosphoesterase
CN246_RS01080	COG1418	mRNA catabolic process
CN246_RS01085	COG0542	response to heat
CN246_RS01090	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CN246_RS01095	COG3880	PFAM UvrB UvrC protein
CN246_RS01120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CN246_RS01125	COG0006	proline dipeptidase activity
CN246_RS01130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CN246_RS01145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CN246_RS01155	COG2308	Evidence 4 Homologs of previously reported genes of
CN246_RS01170	COG3608	succinylglutamate desuccinylase aspartoacylase
CN246_RS01180	COG2119	membrane
CN246_RS01185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CN246_RS01205	COG0674	pyruvate-flavodoxin oxidoreductase activity
CN246_RS01205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CN246_RS01220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CN246_RS01230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CN246_RS01240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CN246_RS01245	COG0180	Tryptophanyl-tRNA synthetase
CN246_RS01250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CN246_RS01260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CN246_RS01265	COG0573	inorganic phosphate transmembrane transporter activity
CN246_RS01270	COG0581	inorganic phosphate transmembrane transporter activity
CN246_RS01275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CN246_RS01280	COG0704	Plays a role in the regulation of phosphate uptake
CN246_RS01285	COG0745	RESPONSE REGULATOR receiver
CN246_RS01290	COG5002	protein histidine kinase activity
CN246_RS01295	COG1254	Belongs to the acylphosphatase family
CN246_RS01305	COG1606	tRNA processing
CN246_RS01310	COG0628	permease
CN246_RS01350	COG1250	3-hydroxyacyl-CoA dehydrogenase
CN246_RS01355	COG1960	acyl-CoA dehydrogenase activity
CN246_RS01370	COG1136	(ABC) transporter
CN246_RS01370	COG0577	efflux transmembrane transporter activity
CN246_RS01415	COG1131	(ABC) transporter
CN246_RS01430	COG0736	holo-[acyl-carrier-protein] synthase activity
CN246_RS01450	COG0517	IMP dehydrogenase activity
CN246_RS01450	COG0516	GMP reductase activity
CN246_RS01465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CN246_RS01495	COG1131	(ABC) transporter
CN246_RS01500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CN246_RS01505	COG0124	histidyl-tRNA synthetase
CN246_RS01510	COG1803	Methylglyoxal synthase
CN246_RS01515	COG2894	cell division
CN246_RS01520	COG0768	penicillin binding
CN246_RS01540	COG2002	toxin-antitoxin pair type II binding
CN246_RS01555	COG0826	peptidase U32
CN246_RS01570	COG0450	alkyl hydroperoxide reductase
CN246_RS01585	COG4509	Sortase family
CN246_RS01595	COG1876	peptidase activity
CN246_RS01615	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CN246_RS01625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CN246_RS01630	COG0758	DNA mediated transformation
CN246_RS01630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CN246_RS01635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CN246_RS01640	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CN246_RS01645	COG0416	fatty acid biosynthetic process
CN246_RS01650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CN246_RS01655	COG0571	ribonuclease III activity
CN246_RS01670	COG1196	nuclear chromosome segregation
CN246_RS01675	COG0552	protein localization to endoplasmic reticulum
CN246_RS01680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CN246_RS01690	COG1534	Rna-binding protein
CN246_RS01695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CN246_RS01700	COG1713	HD superfamily hydrolase involved in NAD metabolism
CN246_RS01705	COG0799	negative regulation of ribosome biogenesis
CN246_RS01710	COG0495	leucyl-tRNA aminoacylation
CN246_RS01730	COG1136	(ABC) transporter
CN246_RS01730	COG0577	efflux transmembrane transporter activity
CN246_RS01735	COG2205	protein histidine kinase activity
CN246_RS01735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CN246_RS01740	COG0745	RESPONSE REGULATOR receiver
CN246_RS01745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CN246_RS01750	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CN246_RS01755	COG0017	Asparaginyl-tRNA synthetase
CN246_RS01760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CN246_RS01760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CN246_RS01765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CN246_RS01780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CN246_RS01785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CN246_RS01805	COG3956	TIGRFAM MazG family protein
CN246_RS01815	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CN246_RS01840	COG1098	S1 RNA binding domain
CN246_RS01845	COG0492	ferredoxin-NADP+ reductase activity
CN246_RS01850	COG1228	amidohydrolase
CN246_RS01875	COG0116	Belongs to the methyltransferase superfamily
CN246_RS01880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CN246_RS01885	COG0459	protein refolding
CN246_RS01890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CN246_RS01905	COG0051	transcription antitermination factor activity, RNA binding
CN246_RS01910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CN246_RS01915	COG0088	Forms part of the polypeptide exit tunnel
CN246_RS01920	COG0089	rRNA binding
CN246_RS01930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CN246_RS01935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CN246_RS01940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CN246_RS01950	COG0255	Belongs to the universal ribosomal protein uL29 family
CN246_RS01955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CN246_RS01960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CN246_RS01965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CN246_RS01970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CN246_RS01975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CN246_RS01980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CN246_RS01985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CN246_RS01990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CN246_RS01995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CN246_RS02015	COG0563	adenylate kinase activity
CN246_RS02020	COG0024	Methionine aminopeptidase
CN246_RS02030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CN246_RS02040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CN246_RS02050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CN246_RS02055	COG0202	RNA polymerase activity
CN246_RS02060	COG0203	ribosomal protein L17
CN246_RS02085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CN246_RS02090	COG1131	(ABC) transporter
CN246_RS02115	COG1305	Transglutaminase-like
CN246_RS02125	COG0714	Associated with various cellular activities
CN246_RS02145	COG1217	gtp-binding protein TYPA
CN246_RS02165	COG0840	transmembrane signaling receptor activity
CN246_RS02185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CN246_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
CN246_RS02195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CN246_RS02240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CN246_RS02245	COG3459	Glycosyltransferase 36 associated
CN246_RS02250	COG4496	protein, YerC YecD
CN246_RS02255	COG2226	methyltransferase
CN246_RS02260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CN246_RS02265	COG0038	chloride channel
CN246_RS02280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CN246_RS02285	COG0792	nuclease activity
CN246_RS02290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CN246_RS02295	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CN246_RS02310	COG0335	large ribosomal subunit rRNA binding
CN246_RS02325	COG0019	diaminopimelate decarboxylase activity
CN246_RS02330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CN246_RS02335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CN246_RS02340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CN246_RS02345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CN246_RS02355	COG1215	transferase activity, transferring glycosyl groups
CN246_RS02390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CN246_RS02415	COG1115	amino acid carrier protein
CN246_RS02425	COG0582	viral genome integration into host DNA
CN246_RS02445	COG3843	relaxase mobilization nuclease domain protein
CN246_RS02460	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CN246_RS02470	COG0732	type I restriction modification DNA specificity domain
CN246_RS02495	COG1715	Restriction endonuclease
CN246_RS02695	COG1484	DNA-dependent DNA replication
CN246_RS02710	COG1396	sequence-specific DNA binding
CN246_RS02720	COG1715	Restriction endonuclease
CN246_RS02750	COG1131	(ABC) transporter
CN246_RS02785	COG3041	Addiction module toxin RelE StbE family
CN246_RS02805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CN246_RS02805	COG1017	nitric oxide dioxygenase activity
CN246_RS02825	COG2205	protein histidine kinase activity
CN246_RS02825	COG0784	Response regulator, receiver
CN246_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
CN246_RS02840	COG0583	DNA-binding transcription factor activity
CN246_RS02895	COG1131	(ABC) transporter
CN246_RS02905	COG1349	DNA-binding transcription factor activity
CN246_RS02930	COG3842	ATPase activity
CN246_RS02945	COG1482	cell wall glycoprotein biosynthetic process
CN246_RS02955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CN246_RS02955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CN246_RS02955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CN246_RS02960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CN246_RS02965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CN246_RS02965	COG3711	transcriptional antiterminator
CN246_RS02985	COG0824	Thioesterase
CN246_RS02995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CN246_RS03000	COG1012	belongs to the aldehyde dehydrogenase family
CN246_RS03010	COG1454	alcohol dehydrogenase
CN246_RS03015	COG1396	sequence-specific DNA binding
CN246_RS03030	COG3842	ATPase activity
CN246_RS03035	COG1176	ABC-type spermidine putrescine transport system, permease component I
CN246_RS03040	COG1177	transmembrane transport
CN246_RS03050	COG0745	RESPONSE REGULATOR receiver
CN246_RS03055	COG5002	protein histidine kinase activity
CN246_RS03060	COG1136	(ABC) transporter
CN246_RS03080	COG3730	PTS system glucitol sorbitol-specific
CN246_RS03100	COG1725	Transcriptional regulator
CN246_RS03105	COG1131	(ABC) transporter
CN246_RS03120	COG1131	(ABC) transporter
CN246_RS03125	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CN246_RS03130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CN246_RS03145	COG0730	response to heat
CN246_RS03155	COG0583	DNA-binding transcription factor activity
CN246_RS03160	COG2855	membrane
CN246_RS03205	COG4372	Transposase
CN246_RS03220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CN246_RS03225	COG2814	Major facilitator Superfamily
CN246_RS03245	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CN246_RS03250	COG1733	regulation of RNA biosynthetic process
CN246_RS03265	COG4372	Transposase
CN246_RS03275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CN246_RS03330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CN246_RS03335	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CN246_RS03340	COG1518	maintenance of DNA repeat elements
CN246_RS03375	COG0562	UDP-galactopyranose mutase
CN246_RS03385	COG1609	Transcriptional regulator
CN246_RS03395	COG1268	BioY protein
CN246_RS03420	COG1609	Transcriptional regulator
CN246_RS03435	COG1086	Polysaccharide biosynthesis protein
CN246_RS03470	COG0438	transferase activity, transferring glycosyl groups
CN246_RS03480	COG0438	transferase activity, transferring glycosyl groups
CN246_RS03490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CN246_RS03495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CN246_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
CN246_RS03535	COG0251	oxidation-reduction process
CN246_RS03540	COG1959	2 iron, 2 sulfur cluster binding
CN246_RS03550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CN246_RS03560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CN246_RS03565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CN246_RS03570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CN246_RS03575	COG1923	regulation of RNA biosynthetic process
CN246_RS03585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CN246_RS03590	COG1799	cell septum assembly
CN246_RS03600	COG2302	S4 RNA-binding domain
CN246_RS03620	COG0564	pseudouridine synthase activity
CN246_RS03630	COG3959	Transketolase, thiamine diphosphate binding domain
CN246_RS03635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CN246_RS03640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CN246_RS03650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CN246_RS03660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CN246_RS03665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CN246_RS03675	COG0517	IMP dehydrogenase activity
CN246_RS03685	COG0750	zinc metalloprotease
CN246_RS03690	COG0745	RESPONSE REGULATOR receiver
CN246_RS03725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CN246_RS03730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CN246_RS03735	COG3711	transcriptional antiterminator
CN246_RS03740	COG2190	(PTS) system
CN246_RS03745	COG2190	(PTS) system
CN246_RS03745	COG1263	PTS System
CN246_RS03745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CN246_RS03750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CN246_RS03760	COG2719	SpoVR family
CN246_RS03765	COG2718	Belongs to the UPF0229 family
CN246_RS03770	COG2766	serine protein kinase
CN246_RS03780	COG3588	fructose-bisphosphate aldolase
CN246_RS03790	COG0076	glutamate decarboxylase activity
CN246_RS03800	COG1748	Saccharopine dehydrogenase
CN246_RS03805	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CN246_RS03810	COG1982	Orn Lys Arg decarboxylase major
CN246_RS03825	COG0281	malic enzyme
CN246_RS03840	COG1940	carbohydrate kinase activity
CN246_RS03870	COG0366	Alpha amylase catalytic
CN246_RS03875	COG0366	Alpha amylase catalytic
CN246_RS03890	COG1609	Transcriptional regulator
CN246_RS03895	COG1653	transport
CN246_RS03905	COG0395	ABC-type sugar transport system, permease component
CN246_RS03920	COG2017	converts alpha-aldose to the beta-anomer
CN246_RS03925	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CN246_RS03930	COG1085	galactose-1-phosphate uridylyltransferase
CN246_RS03935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CN246_RS03945	COG1181	Belongs to the D-alanine--D-alanine ligase family
CN246_RS03950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CN246_RS03960	COG0018	arginyl-trna synthetase
CN246_RS03965	COG1408	metallophosphoesterase
CN246_RS03970	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CN246_RS03980	COG1040	competence protein
CN246_RS03985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CN246_RS04000	COG0789	Transcriptional regulator
CN246_RS04010	COG2385	sporulation resulting in formation of a cellular spore
CN246_RS04025	COG1045	serine acetyltransferase
CN246_RS04030	COG0215	cysteine-tRNA ligase activity
CN246_RS04035	COG0583	DNA-binding transcription factor activity
CN246_RS04045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CN246_RS04050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CN246_RS04055	COG0640	Transcriptional regulator
CN246_RS04060	COG5658	integral membrane protein
CN246_RS04065	COG2755	lipolytic protein G-D-S-L family
CN246_RS04065	COG1083	cytidylyl-transferase
CN246_RS04070	COG1477	protein flavinylation
CN246_RS04075	COG3901	Regulator of nitric oxide reductase transcription
CN246_RS04075	COG0348	domain, Protein
CN246_RS04090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CN246_RS04095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CN246_RS04110	COG4968	Prepilin-type N-terminal cleavage methylation domain
CN246_RS04115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CN246_RS04150	COG1459	type II secretion system
CN246_RS04155	COG0390	transport system, permease component
CN246_RS04160	COG4619	ABC transporter
CN246_RS04165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CN246_RS04175	COG3845	ABC transporter
CN246_RS04180	COG4603	Belongs to the binding-protein-dependent transport system permease family
CN246_RS04185	COG1079	Belongs to the binding-protein-dependent transport system permease family
CN246_RS04190	COG0110	maltose O-acetyltransferase activity
CN246_RS04215	COG0840	transmembrane signaling receptor activity
CN246_RS04220	COG0561	phosphatase activity
CN246_RS04230	COG3716	PTS system mannose fructose sorbose family IID component
CN246_RS04260	COG2197	response regulator
CN246_RS04265	COG4585	Histidine kinase
CN246_RS04270	COG1879	ABC-type sugar transport system periplasmic component
CN246_RS04275	COG1971	Probably functions as a manganese efflux pump
CN246_RS04285	COG1621	beta-fructofuranosidase activity
CN246_RS04295	COG1609	Transcriptional regulator
CN246_RS04305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CN246_RS04320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CN246_RS04335	COG1482	cell wall glycoprotein biosynthetic process
CN246_RS04340	COG0561	phosphatase activity
CN246_RS04345	COG2723	6-phospho-beta-galactosidase activity
CN246_RS04350	COG2188	Transcriptional regulator
CN246_RS04355	COG2723	6-phospho-beta-galactosidase activity
CN246_RS04365	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CN246_RS04370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CN246_RS04375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CN246_RS04380	COG1993	acr, cog1993
CN246_RS04385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CN246_RS04390	COG1120	ATPase activity
CN246_RS04395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN246_RS04405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CN246_RS04410	COG0521	Mo-molybdopterin cofactor biosynthetic process
CN246_RS04415	COG0303	'Molybdopterin
CN246_RS04420	COG1215	transferase activity, transferring glycosyl groups
CN246_RS04430	COG1393	Belongs to the ArsC family
CN246_RS04435	COG1732	Glycine betaine
CN246_RS04460	COG2972	Histidine kinase
CN246_RS04460	COG0745	RESPONSE REGULATOR receiver
CN246_RS04470	COG4932	domain protein
CN246_RS04470	COG5492	domain, Protein
CN246_RS04495	COG1132	(ABC) transporter
CN246_RS04505	COG3279	Response regulator of the LytR AlgR family
CN246_RS04570	COG4372	Transposase
CN246_RS04585	COG1215	transferase activity, transferring glycosyl groups
CN246_RS04590	COG1215	transferase activity, transferring glycosyl groups
CN246_RS04615	COG4372	Transposase
CN246_RS04620	COG1902	pentaerythritol trinitrate reductase activity
CN246_RS04620	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN246_RS04635	COG4989	oxidoreductase activity
CN246_RS04645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CN246_RS04650	COG1482	cell wall glycoprotein biosynthetic process
CN246_RS04660	COG2723	6-phospho-beta-galactosidase activity
CN246_RS04675	COG2207	Transcriptional regulator
CN246_RS04675	COG1917	Cupin 2, conserved barrel domain protein
CN246_RS04685	COG1175	transmembrane transport
CN246_RS04690	COG0395	ABC-type sugar transport system, permease component
CN246_RS04695	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CN246_RS04705	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CN246_RS04720	COG0840	transmembrane signaling receptor activity
CN246_RS04725	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CN246_RS04735	COG0395	ABC-type sugar transport system, permease component
CN246_RS04740	COG1653	transport
CN246_RS04745	COG3842	ATPase activity
CN246_RS04750	COG0584	glycerophosphoryl diester phosphodiesterase
CN246_RS04780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CN246_RS04785	COG0436	Aminotransferase
CN246_RS04790	COG2388	GCN5-related N-acetyl-transferase
CN246_RS04805	COG0473	3-isopropylmalate dehydrogenase activity
CN246_RS04810	COG0066	3-isopropylmalate dehydratase activity
CN246_RS04815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CN246_RS04820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CN246_RS04825	COG0028	Belongs to the TPP enzyme family
CN246_RS04855	COG1846	Transcriptional regulator
CN246_RS04860	COG2814	Major facilitator Superfamily
CN246_RS04865	COG1396	sequence-specific DNA binding
CN246_RS04900	COG0778	Nitroreductase
CN246_RS04905	COG1733	regulation of RNA biosynthetic process
CN246_RS04945	COG0500	methyltransferase
CN246_RS04950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CN246_RS04965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CN246_RS04975	COG1715	Restriction endonuclease
CN246_RS04980	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CN246_RS04980	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CN246_RS05020	COG1881	PFAM PEBP family protein
CN246_RS05040	COG4372	Transposase
CN246_RS05050	COG0583	DNA-binding transcription factor activity
CN246_RS05065	COG2878	Part of a membrane complex involved in electron transport
CN246_RS05065	COG1245	4Fe-4S binding domain
CN246_RS05070	COG0798	PFAM Bile acid sodium symporter
CN246_RS05075	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN246_RS05080	COG0740	serine-type endopeptidase activity
CN246_RS05085	COG4977	sequence-specific DNA binding
CN246_RS05095	COG2217	Heavy metal translocating P-type atpase
CN246_RS05115	COG1131	(ABC) transporter
CN246_RS05135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN246_RS05140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CN246_RS05150	COG2217	Heavy metal translocating P-type atpase
CN246_RS05160	COG0785	Cytochrome C biogenesis protein
CN246_RS05170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN246_RS05190	COG1136	(ABC) transporter
CN246_RS05195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CN246_RS05200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN246_RS05215	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CN246_RS05250	COG1335	isochorismatase
CN246_RS05255	COG0789	Transcriptional regulator
CN246_RS05275	COG0542	response to heat
CN246_RS05280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CN246_RS05295	COG0101	tRNA pseudouridine synthase activity
CN246_RS05300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CN246_RS05305	COG1122	ATPase activity
CN246_RS05310	COG1122	ATPase activity
CN246_RS05320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CN246_RS05325	COG2255	four-way junction helicase activity
CN246_RS05330	COG0632	four-way junction helicase activity
CN246_RS05345	COG0037	tRNA processing
CN246_RS05365	COG0745	RESPONSE REGULATOR receiver
CN246_RS05375	COG1136	(ABC) transporter
CN246_RS05380	COG0577	efflux transmembrane transporter activity
CN246_RS05395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CN246_RS05400	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CN246_RS05405	COG0154	amidase activity
CN246_RS05410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CN246_RS05415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CN246_RS05430	COG0513	Belongs to the DEAD box helicase family
CN246_RS05450	COG0745	RESPONSE REGULATOR receiver
CN246_RS05455	COG5002	protein histidine kinase activity
CN246_RS05465	COG0254	rRNA binding
CN246_RS05470	COG1739	Uncharacterized protein family UPF0029
CN246_RS05475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CN246_RS05480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CN246_RS05485	COG0358	DNA primase activity
CN246_RS05490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CN246_RS05500	COG1773	rubredoxin
CN246_RS05505	COG0426	domain, Protein
CN246_RS05515	COG0484	heat shock protein binding
CN246_RS05530	COG2217	Heavy metal translocating P-type atpase
CN246_RS05535	COG2217	Heavy metal translocating P-type atpase
CN246_RS05555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CN246_RS05560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CN246_RS05565	COG0049	tRNA binding
CN246_RS05570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CN246_RS05575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CN246_RS05585	COG2337	Toxic component of a toxin-antitoxin (TA) module
CN246_RS05605	COG0546	phosphoglycolate phosphatase activity
CN246_RS05615	COG1595	DNA-templated transcription, initiation
CN246_RS05635	COG2384	SAM-dependent methyltransferase
CN246_RS05640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CN246_RS05645	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CN246_RS05660	COG0739	heme binding
CN246_RS05670	COG0179	Fumarylacetoacetate (FAA) hydrolase
CN246_RS05690	COG1408	metallophosphoesterase
CN246_RS05700	COG0017	Asparaginyl-tRNA synthetase
CN246_RS05705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CN246_RS05710	COG0154	amidase activity
CN246_RS05715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CN246_RS05735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CN246_RS05735	COG1918	ferrous iron import across plasma membrane
CN246_RS05750	COG1316	TRANSCRIPTIONal
CN246_RS05755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CN246_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
CN246_RS05795	COG0583	DNA-binding transcription factor activity
CN246_RS05830	COG3850	Histidine kinase
CN246_RS05830	COG5002	protein histidine kinase activity
CN246_RS05840	COG1968	undecaprenyl-diphosphatase activity
CN246_RS05850	COG1131	(ABC) transporter
CN246_RS05855	COG5002	protein histidine kinase activity
CN246_RS05880	COG4585	Histidine kinase
CN246_RS05885	COG2197	response regulator
CN246_RS05895	COG1136	(ABC) transporter
CN246_RS05910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CN246_RS05920	COG1136	(ABC) transporter
CN246_RS05925	COG0577	efflux transmembrane transporter activity
CN246_RS05925	COG1136	(ABC) transporter
CN246_RS05935	COG0367	asparagine synthase
CN246_RS05940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CN246_RS05945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CN246_RS05955	COG1686	Belongs to the peptidase S11 family
CN246_RS05960	COG0166	Belongs to the GPI family
CN246_RS05975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CN246_RS05985	COG1160	GTP binding
CN246_RS05990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CN246_RS05995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CN246_RS06010	COG2323	membrane
CN246_RS06030	COG1454	alcohol dehydrogenase
CN246_RS06035	COG1116	anion transmembrane transporter activity
CN246_RS06045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CN246_RS06050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CN246_RS06055	COG1683	Conserved Protein
CN246_RS06060	COG2508	Transcriptional regulator
CN246_RS06080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CN246_RS06120	COG1686	Belongs to the peptidase S11 family
CN246_RS06125	COG0583	DNA-binding transcription factor activity
CN246_RS06160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CN246_RS06170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CN246_RS06180	COG1381	Involved in DNA repair and RecF pathway recombination
CN246_RS06205	COG3757	hydrolase, family 25
CN246_RS06205	COG3409	Peptidoglycan-binding domain 1 protein
CN246_RS06210	COG2255	four-way junction helicase activity
CN246_RS06255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CN246_RS06260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CN246_RS06265	COG1570	exodeoxyribonuclease VII activity
CN246_RS06270	COG1722	exodeoxyribonuclease VII activity
CN246_RS06275	COG0142	geranyltranstransferase activity
CN246_RS06280	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CN246_RS06285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CN246_RS06290	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CN246_RS06295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CN246_RS06300	COG1438	arginine binding
CN246_RS06305	COG0497	DNA recombination
CN246_RS06310	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CN246_RS06395	COG4372	Transposase
CN246_RS06495	COG1690	Belongs to the RtcB family
CN246_RS06570	COG1074	ATP-dependent DNA helicase activity
CN246_RS06575	COG0443	Heat shock 70 kDa protein
CN246_RS06625	COG1393	Belongs to the ArsC family
CN246_RS06645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CN246_RS06690	COG1122	ATPase activity
CN246_RS06695	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CN246_RS06700	COG0310	cobalt ion transport
CN246_RS06705	COG1691	(AIR) carboxylase
CN246_RS06740	COG1131	(ABC) transporter
CN246_RS06755	COG0315	cyclic pyranopterin monophosphate synthase activity
CN246_RS06775	COG2770	Histidine kinase
CN246_RS06775	COG3437	response regulator, receiver
CN246_RS06785	COG2959	enzyme of heme biosynthesis
CN246_RS06815	COG0668	transmembrane transport
CN246_RS06825	COG0512	Glutamine amidotransferase of anthranilate synthase
CN246_RS06825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CN246_RS06830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CN246_RS06835	COG0134	indole-3-glycerol-phosphate synthase activity
CN246_RS06845	COG0133	tryptophan synthase activity
CN246_RS06850	COG0159	tryptophan synthase activity
CN246_RS06855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CN246_RS06870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CN246_RS06880	COG1104	cysteine desulfurase activity
CN246_RS06890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CN246_RS06900	COG2239	Acts as a magnesium transporter
CN246_RS06905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CN246_RS06910	COG0488	(ABC) transporter
CN246_RS06925	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CN246_RS06930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CN246_RS06935	COG1940	carbohydrate kinase activity
CN246_RS06945	COG1660	Displays ATPase and GTPase activities
CN246_RS06950	COG1481	regulation of sporulation
CN246_RS06975	COG0493	'glutamate synthase
CN246_RS06975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CN246_RS06980	COG0039	L-malate dehydrogenase activity
CN246_RS06985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CN246_RS07045	COG1131	(ABC) transporter
CN246_RS07055	COG3620	sequence-specific DNA binding
CN246_RS07060	COG2814	Major facilitator Superfamily
CN246_RS07070	COG1704	LemA family
CN246_RS07080	COG0569	domain protein
CN246_RS07085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CN246_RS07095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CN246_RS07125	COG0726	polysaccharide deacetylase
CN246_RS07130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CN246_RS07140	COG0646	methionine synthase
CN246_RS07140	COG1410	methionine synthase
CN246_RS07145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CN246_RS07160	COG0588	phosphoglycerate mutase activity
CN246_RS07175	COG1454	alcohol dehydrogenase
CN246_RS07175	COG1012	belongs to the aldehyde dehydrogenase family
CN246_RS07180	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CN246_RS07185	COG0473	3-isopropylmalate dehydrogenase activity
CN246_RS07190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CN246_RS07195	COG1924	4 iron, 4 sulfur cluster binding
CN246_RS07205	COG0740	serine-type endopeptidase activity
CN246_RS07215	COG1674	ftsk spoiiie
CN246_RS07225	COG2333	competence protein COMEC
CN246_RS07225	COG0658	competence protein
CN246_RS07240	COG1132	(ABC) transporter
CN246_RS07245	COG0450	alkyl hydroperoxide reductase
CN246_RS07250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CN246_RS07295	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CN246_RS07300	COG0860	N-Acetylmuramoyl-L-alanine amidase
CN246_RS07305	COG1376	ErfK ybiS ycfS ynhG family protein
CN246_RS07310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CN246_RS07315	COG4974	Belongs to the 'phage' integrase family
CN246_RS07320	COG4974	Belongs to the 'phage' integrase family
CN246_RS07330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CN246_RS07350	COG1862	Preprotein translocase
CN246_RS07360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CN246_RS07375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CN246_RS07395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CN246_RS07405	COG0803	Belongs to the bacterial solute-binding protein 9 family
CN246_RS07415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CN246_RS07420	COG0107	imidazoleglycerol-phosphate synthase activity
CN246_RS07425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CN246_RS07430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CN246_RS07440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CN246_RS07445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CN246_RS07450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CN246_RS07455	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CN246_RS07470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CN246_RS07470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CN246_RS07475	COG4106	trans-aconitate 2-methyltransferase activity
CN246_RS07480	COG2197	response regulator
CN246_RS07485	COG4585	Histidine kinase
CN246_RS07490	COG1131	(ABC) transporter
CN246_RS07505	COG4221	oxidoreductase activity
CN246_RS07510	COG2723	6-phospho-beta-galactosidase activity
CN246_RS07515	COG0840	transmembrane signaling receptor activity
CN246_RS07525	COG1074	ATP-dependent DNA helicase activity
CN246_RS07535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CN246_RS07535	COG0539	negative regulation of cytoplasmic translation
CN246_RS07540	COG0204	Acyl-transferase
CN246_RS07545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CN246_RS07550	COG2081	HI0933 family
CN246_RS07560	COG4474	Belongs to the UPF0398 family
CN246_RS07565	COG0622	Phosphoesterase
CN246_RS07570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CN246_RS07575	COG0105	UTP biosynthetic process
CN246_RS07580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CN246_RS07585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CN246_RS07605	COG0194	GDP metabolic process
CN246_RS07630	COG1854	S-ribosylhomocysteine lyase activity
CN246_RS07655	COG0561	phosphatase activity
CN246_RS07665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CN246_RS07675	COG1105	Belongs to the carbohydrate kinase PfkB family
CN246_RS07680	COG1349	DNA-binding transcription factor activity
CN246_RS07685	COG0525	valine-tRNA ligase activity
CN246_RS07690	COG2703	oxygen carrier activity
CN246_RS07705	COG2172	sigma factor antagonist activity
CN246_RS07710	COG1191	sigma factor activity
CN246_RS07720	COG0419	ATPase involved in DNA repair
CN246_RS07725	COG2022	thiamine diphosphate biosynthetic process
CN246_RS07735	COG0352	thiamine-phosphate diphosphorylase activity
CN246_RS07750	COG1335	isochorismatase
CN246_RS07760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CN246_RS07765	COG0655	NAD(P)H dehydrogenase (quinone) activity
CN246_RS07775	COG0697	spore germination
CN246_RS07780	COG0583	DNA-binding transcription factor activity
CN246_RS07785	COG0789	Transcriptional regulator
CN246_RS07800	COG0789	Transcriptional regulator
CN246_RS07805	COG0730	response to heat
CN246_RS07810	COG1309	transcriptional regulator
CN246_RS07820	COG0768	penicillin binding
CN246_RS07845	COG1686	Belongs to the peptidase S11 family
CN246_RS07850	COG2226	methyltransferase
CN246_RS07865	COG0556	nucleotide-excision repair
CN246_RS07875	COG0564	pseudouridine synthase activity
CN246_RS07880	COG2244	polysaccharide biosynthetic process
CN246_RS07885	COG0586	Pfam SNARE associated Golgi protein
CN246_RS07895	COG0540	Belongs to the ATCase OTCase family
CN246_RS07920	COG1682	transport, permease protein
CN246_RS07935	COG1091	dTDP-4-dehydrorhamnose reductase activity
CN246_RS07950	COG1215	transferase activity, transferring glycosyl groups
CN246_RS07955	COG1216	Glycosyl transferase, family 2
CN246_RS07975	COG0126	phosphoglycerate kinase activity
CN246_RS07980	COG0149	triose-phosphate isomerase activity
CN246_RS07985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CN246_RS07990	COG0700	Nucleoside recognition
CN246_RS07995	COG2715	membrane protein required for spore maturation
CN246_RS08000	COG2002	toxin-antitoxin pair type II binding
CN246_RS08005	COG0590	tRNA wobble adenosine to inosine editing
CN246_RS08050	COG0535	radical SAM domain protein
CN246_RS08050	COG1433	Dinitrogenase iron-molybdenum cofactor
CN246_RS08070	COG0347	Belongs to the P(II) protein family
CN246_RS08090	COG1120	ATPase activity
CN246_RS08100	COG1910	domain protein
CN246_RS08105	COG0725	ABC transporter, periplasmic molybdate-binding protein
CN246_RS08110	COG4149	molybdate abc transporter
CN246_RS08115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CN246_RS08135	COG0346	lactoylglutathione lyase activity
CN246_RS08140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CN246_RS08150	COG1959	2 iron, 2 sulfur cluster binding
CN246_RS08275	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CN246_RS08280	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CN246_RS08290	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CN246_RS08295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CN246_RS08310	COG0010	Belongs to the arginase family
CN246_RS08315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CN246_RS08320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CN246_RS08330	COG3706	GGDEF domain
CN246_RS08340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CN246_RS08345	COG0750	zinc metalloprotease
CN246_RS08350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CN246_RS08355	COG4589	Belongs to the CDS family
CN246_RS08365	COG0233	cytoplasmic translational termination
CN246_RS08370	COG0528	UMP kinase activity
CN246_RS08375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CN246_RS08380	COG0052	Belongs to the universal ribosomal protein uS2 family
CN246_RS08385	COG1873	PFAM PRC-barrel domain
CN246_RS08390	COG1191	sigma factor activity
CN246_RS08395	COG1191	sigma factor activity
CN246_RS08405	COG2211	Major facilitator Superfamily
CN246_RS08410	COG0484	heat shock protein binding
CN246_RS08415	COG0443	Heat shock 70 kDa protein
CN246_RS08425	COG1420	regulation of RNA biosynthetic process
CN246_RS08435	COG0481	GTPase activity
CN246_RS08440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CN246_RS08450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CN246_RS08460	COG4509	Sortase family
CN246_RS08465	COG1058	Belongs to the CinA family
CN246_RS08465	COG1546	Belongs to the CinA family
CN246_RS08470	COG0301	tRNA thio-modification
CN246_RS08475	COG1104	cysteine desulfurase activity
CN246_RS08480	COG0504	CTP synthase activity
CN246_RS08485	COG3384	dioxygenase
CN246_RS08490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CN246_RS08495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CN246_RS08500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CN246_RS08505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CN246_RS08510	COG0612	Peptidase, M16
CN246_RS08525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CN246_RS08530	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CN246_RS08535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CN246_RS08550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CN246_RS08550	COG0438	transferase activity, transferring glycosyl groups
CN246_RS08570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CN246_RS08575	COG0791	NLP P60 protein
CN246_RS08575	COG1388	LysM domain
CN246_RS08575	COG3103	Sh3 type 3 domain protein
CN246_RS08620	COG4372	Transposase
CN246_RS08685	COG3800	Transcriptional regulator
CN246_RS08685	COG1396	sequence-specific DNA binding
CN246_RS08700	COG1309	transcriptional regulator
CN246_RS08720	COG2323	membrane
CN246_RS08735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CN246_RS08755	COG2814	Major facilitator Superfamily
CN246_RS08800	COG0519	Catalyzes the synthesis of GMP from XMP
CN246_RS08805	COG0772	Belongs to the SEDS family
CN246_RS08810	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CN246_RS08815	COG0802	atpase or kinase
CN246_RS08820	COG1214	PFAM Peptidase M22, glycoprotease
CN246_RS08825	COG0698	ribose 5-phosphate isomerase
CN246_RS08830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CN246_RS08835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CN246_RS08860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CN246_RS08865	COG1121	(ABC) transporter
CN246_RS08880	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CN246_RS08890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CN246_RS08895	COG2873	o-acetylhomoserine
CN246_RS08900	COG0626	cystathionine gamma-synthase activity
CN246_RS08905	COG0436	Aminotransferase
CN246_RS08915	COG2011	ABC-type metal ion transport system permease component
CN246_RS08920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CN246_RS08925	COG0436	Aminotransferase
CN246_RS08930	COG1464	Belongs to the NlpA lipoprotein family
CN246_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
CN246_RS08955	COG0463	Glycosyl transferase, family 2
CN246_RS08960	COG0371	Dehydrogenase
CN246_RS08965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CN246_RS08970	COG0513	Belongs to the DEAD box helicase family
CN246_RS08990	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CN246_RS09000	COG1151	hydroxylamine reductase activity
CN246_RS09025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CN246_RS09030	COG1116	anion transmembrane transporter activity
CN246_RS09050	COG2205	protein histidine kinase activity
CN246_RS09055	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CN246_RS09060	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CN246_RS09065	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CN246_RS09075	COG5002	protein histidine kinase activity
CN246_RS09080	COG2204	response regulator
CN246_RS09090	COG4608	Belongs to the ABC transporter superfamily
CN246_RS09095	COG0444	Belongs to the ABC transporter superfamily
CN246_RS09100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CN246_RS09105	COG0601	transmembrane transport
CN246_RS09110	COG4166	transmembrane transport
CN246_RS09115	COG1131	(ABC) transporter
CN246_RS09125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CN246_RS09130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CN246_RS09135	COG0725	ABC transporter, periplasmic molybdate-binding protein
CN246_RS09155	COG4608	Belongs to the ABC transporter superfamily
CN246_RS09160	COG0444	Belongs to the ABC transporter superfamily
CN246_RS09165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CN246_RS09175	COG0747	negative chemotaxis
CN246_RS09185	COG3639	organic phosphonate transmembrane transporter activity
CN246_RS09205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CN246_RS09210	COG1609	Transcriptional regulator
CN246_RS09215	COG4260	virion core protein, lumpy skin disease virus
CN246_RS09230	COG2972	Histidine kinase
CN246_RS09230	COG0745	RESPONSE REGULATOR receiver
CN246_RS09235	COG2199	diguanylate cyclase activity
CN246_RS09245	COG2201	protein-glutamate methylesterase activity
CN246_RS09250	COG2198	Histidine kinase
CN246_RS09250	COG0643	Histidine kinase
CN246_RS09255	COG1406	Chemotaxis phosphatase CheX
CN246_RS09265	COG0584	glycerophosphoryl diester phosphodiesterase
CN246_RS09275	COG2208	phosphoserine phosphatase activity
CN246_RS09275	COG2770	Histidine kinase
CN246_RS09280	COG1366	Belongs to the anti-sigma-factor antagonist family
CN246_RS09310	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN246_RS09310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CN246_RS09315	COG0069	glutamate synthase activity
CN246_RS09325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CN246_RS09330	COG0174	glutamine synthetase
CN246_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
CN246_RS09360	COG2169	Transcriptional regulator
CN246_RS09370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN246_RS09385	COG0446	pyridine nucleotide-disulphide oxidoreductase
CN246_RS09385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CN246_RS09390	COG1027	Aspartate ammonia-lyase
CN246_RS09395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CN246_RS09430	COG2217	Heavy metal translocating P-type atpase
CN246_RS09495	COG0791	NLP P60 protein
CN246_RS09495	COG0741	lytic transglycosylase activity
CN246_RS09520	COG2088	sporulation resulting in formation of a cellular spore
CN246_RS09560	COG1475	DNA binding
CN246_RS09580	COG1522	sequence-specific DNA binding
CN246_RS09605	COG2207	Transcriptional regulator
CN246_RS09615	COG1653	transport
CN246_RS09620	COG1175	transmembrane transport
CN246_RS09625	COG0395	ABC-type sugar transport system, permease component
CN246_RS09630	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CN246_RS09635	COG1085	galactose-1-phosphate uridylyltransferase
CN246_RS09710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CN246_RS09735	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CN246_RS09845	COG1475	DNA binding
CN246_RS09880	COG4626	Terminase
CN246_RS09880	COG1802	Transcriptional regulator
CN246_RS09890	COG0740	serine-type endopeptidase activity
CN246_RS09950	COG3858	chitin binding
CN246_RS10050	COG0745	RESPONSE REGULATOR receiver
CN246_RS10055	COG5002	protein histidine kinase activity
CN246_RS10060	COG1136	(ABC) transporter
CN246_RS10085	COG1192	Involved in chromosome partitioning
CN246_RS10090	COG1475	DNA binding
CN246_RS10130	COG0701	Predicted permease
CN246_RS10190	COG0791	NLP P60 protein
CN246_RS10190	COG3103	Sh3 type 3 domain protein
CN246_RS10190	COG1388	LysM domain
CN246_RS10210	COG0551	DNA topoisomerase type I activity
CN246_RS10210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CN246_RS10320	COG1968	undecaprenyl-diphosphatase activity
CN246_RS10325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CN246_RS10335	COG0745	RESPONSE REGULATOR receiver
CN246_RS10355	COG4974	Belongs to the 'phage' integrase family
CN246_RS10365	COG1151	hydroxylamine reductase activity
CN246_RS10370	COG1773	rubredoxin
CN246_RS10420	COG4372	Transposase
CN246_RS10510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CN246_RS10510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CN246_RS10515	COG0736	holo-[acyl-carrier-protein] synthase activity
CN246_RS10540	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CN246_RS10550	COG4472	Bacterial protein of unknown function (DUF965)
CN246_RS10555	COG0072	phenylalanine-tRNA ligase activity
CN246_RS10555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CN246_RS10560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CN246_RS10570	COG3706	GGDEF domain
CN246_RS10575	COG1193	negative regulation of DNA recombination
CN246_RS10580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CN246_RS10585	COG1592	Rubrerythrin
CN246_RS10595	COG0326	Molecular chaperone. Has ATPase activity
CN246_RS10600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CN246_RS10605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CN246_RS10615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CN246_RS10625	COG2814	Major facilitator Superfamily
CN246_RS10630	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CN246_RS10635	COG2890	protein-(glutamine-N5) methyltransferase activity
CN246_RS10640	COG3872	metal-dependent enzyme
CN246_RS10645	COG5002	protein histidine kinase activity
CN246_RS10650	COG0745	RESPONSE REGULATOR receiver
CN246_RS10670	COG1971	Probably functions as a manganese efflux pump
CN246_RS10675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CN246_RS10685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CN246_RS10690	COG0297	glycogen (starch) synthase activity
CN246_RS10695	COG0058	SHG alpha-glucan phosphorylase activity
CN246_RS10705	COG1396	sequence-specific DNA binding
CN246_RS10720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CN246_RS10720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CN246_RS10720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CN246_RS10725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CN246_RS10730	COG1323	Belongs to the UPF0348 family
CN246_RS10735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CN246_RS10740	COG2155	Conserved Protein
CN246_RS10775	COG3830	Belongs to the UPF0237 family
CN246_RS10780	COG2848	UPF0210 protein
CN246_RS10795	COG1269	ATP hydrolysis coupled proton transport
CN246_RS10815	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CN246_RS10825	COG1394	ATPase activity, coupled to movement of substances
CN246_RS10845	COG0701	Predicted permease
CN246_RS10865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CN246_RS10875	COG5001	Diguanylate cyclase
CN246_RS10885	COG2326	polyphosphate kinase activity
CN246_RS10905	COG4708	membrane
CN246_RS10920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CN246_RS10950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CN246_RS10955	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CN246_RS10965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CN246_RS10975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CN246_RS10980	COG0772	Belongs to the SEDS family
CN246_RS10985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CN246_RS10990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CN246_RS10995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CN246_RS11000	COG0768	penicillin binding
CN246_RS11010	COG0275	rRNA processing
CN246_RS11015	COG2001	Belongs to the MraZ family
CN246_RS11025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CN246_RS11030	COG0742	ribosomal rna small subunit methyltransferase
CN246_RS11035	COG0322	excinuclease ABC activity
CN246_RS11040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CN246_RS11045	COG0336	Belongs to the RNA methyltransferase TrmD family
CN246_RS11060	COG1837	Belongs to the UPF0109 family
CN246_RS11065	COG0228	four-way junction DNA binding
CN246_RS11070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CN246_RS11075	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CN246_RS11080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CN246_RS11090	COG0250	Participates in transcription elongation, termination and antitermination
CN246_RS11095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CN246_RS11100	COG0081	regulation of translation
CN246_RS11105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CN246_RS11120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CN246_RS11125	COG0193	aminoacyl-tRNA hydrolase activity
CN246_RS11135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CN246_RS11140	COG1776	CheC inhibitor of MCP methylation
CN246_RS11145	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CN246_RS11150	COG0726	polysaccharide deacetylase
CN246_RS11155	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CN246_RS11170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CN246_RS11175	COG0537	adenosine 5'-monophosphoramidase activity
CN246_RS11180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CN246_RS11195	COG3842	ATPase activity
CN246_RS11200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CN246_RS11205	COG2032	superoxide dismutase activity
CN246_RS11210	COG0726	polysaccharide deacetylase
CN246_RS11225	COG2270	Major facilitator Superfamily
CN246_RS11235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CN246_RS11240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CN246_RS11240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CN246_RS11245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CN246_RS11250	COG2814	Major facilitator Superfamily
CN246_RS11260	COG1162	GTPase activity
CN246_RS11265	COG2815	serine threonine protein kinase
CN246_RS11265	COG0515	serine threonine protein kinase
CN246_RS11270	COG0631	protein serine/threonine phosphatase activity
CN246_RS11275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CN246_RS11280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CN246_RS11280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CN246_RS11290	COG0242	peptide deformylase activity
CN246_RS11295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CN246_RS11305	COG0194	GDP metabolic process
CN246_RS11315	COG1561	YicC-like family, N-terminal region
CN246_RS11320	COG1187	pseudouridine synthase activity
CN246_RS11325	COG1686	Belongs to the peptidase S11 family
CN246_RS11330	COG3874	Sporulation protein YtfJ
CN246_RS11340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CN246_RS11345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CN246_RS11350	COG1994	Peptidase M50
CN246_RS11395	COG1733	regulation of RNA biosynthetic process
CN246_RS11420	COG0745	RESPONSE REGULATOR receiver
CN246_RS11425	COG2205	protein histidine kinase activity
CN246_RS11445	COG0745	RESPONSE REGULATOR receiver
CN246_RS11460	COG5002	protein histidine kinase activity
CN246_RS11465	COG0347	Belongs to the P(II) protein family
CN246_RS11475	COG0004	ammonium transporteR
CN246_RS11495	COG0534	Mate efflux family protein
CN246_RS11555	COG0768	penicillin binding
CN246_RS11580	COG0012	GTP binding
CN246_RS11610	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CN246_RS11615	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CN246_RS11625	COG1774	PSP1 C-terminal conserved region
CN246_RS11640	COG3870	Protein conserved in bacteria
CN246_RS11645	COG1982	Orn Lys Arg decarboxylase major
CN246_RS11650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CN246_RS11655	COG2348	transferase activity, transferring amino-acyl groups
CN246_RS11660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CN246_RS11665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CN246_RS11675	COG4684	Psort location CytoplasmicMembrane, score
CN246_RS11685	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CN246_RS11690	COG1983	PspC domain protein
CN246_RS11695	COG0735	belongs to the Fur family
CN246_RS11710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CN246_RS11725	COG1924	4 iron, 4 sulfur cluster binding
CN246_RS11735	COG2340	Cysteine-rich secretory protein family
CN246_RS11740	COG0617	tRNA 3'-terminal CCA addition
CN246_RS11745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CN246_RS11750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CN246_RS11755	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CN246_RS11775	COG0004	ammonium transporteR
CN246_RS11780	COG0347	Belongs to the P(II) protein family
CN246_RS11785	COG1132	(ABC) transporter
CN246_RS11795	COG0583	DNA-binding transcription factor activity
CN246_RS11800	COG1522	sequence-specific DNA binding
CN246_RS11805	COG0436	Aminotransferase
CN246_RS11810	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CN246_RS11815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CN246_RS11825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CN246_RS11865	COG0586	Pfam SNARE associated Golgi protein
CN246_RS11870	COG2188	Transcriptional regulator
CN246_RS11895	COG1725	Transcriptional regulator
CN246_RS11910	COG3842	ATPase activity
CN246_RS11915	COG2333	competence protein COMEC
CN246_RS11915	COG0658	competence protein
CN246_RS11920	COG1695	Transcriptional regulator
CN246_RS11950	COG0167	dihydroorotate dehydrogenase activity
CN246_RS11975	COG2183	response to ionizing radiation
CN246_RS11990	COG1454	alcohol dehydrogenase
CN246_RS12010	COG1126	abc transporter atp-binding protein
CN246_RS12015	COG0765	amino acid transport
CN246_RS12025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CN246_RS12040	COG4187	Peptidase family M20/M25/M40
CN246_RS12045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CN246_RS12050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CN246_RS12055	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CN246_RS12070	COG1477	protein flavinylation
CN246_RS12090	COG0157	Belongs to the NadC ModD family
CN246_RS12095	COG1342	Belongs to the UPF0251 family
CN246_RS12100	COG0475	glutathione-regulated potassium exporter activity
CN246_RS12110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CN246_RS12120	COG3853	Toxic anion resistance protein (TelA)
CN246_RS12155	COG2814	Major facilitator Superfamily
CN246_RS12175	COG0673	inositol 2-dehydrogenase activity
CN246_RS12180	COG1376	ErfK ybiS ycfS ynhG family protein
CN246_RS12185	COG0557	exoribonuclease II activity
CN246_RS12195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CN246_RS12200	COG0187	DNA topoisomerase II activity
CN246_RS12205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CN246_RS12210	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CN246_RS12210	COG0037	tRNA processing
CN246_RS12220	COG0305	Participates in initiation and elongation during chromosome replication
CN246_RS12225	COG0359	binds to the 23S rRNA
CN246_RS12230	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CN246_RS12235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CN246_RS12250	COG0428	transporter
CN246_RS12255	COG0328	RNA-DNA hybrid ribonuclease activity
CN246_RS12270	COG0432	Pfam Uncharacterised protein family UPF0047
CN246_RS12280	COG0493	'glutamate synthase
CN246_RS12295	COG0477	Major facilitator Superfamily
CN246_RS12305	COG0737	Belongs to the 5'-nucleotidase family
CN246_RS12305	COG4085	toxin activity
CN246_RS12305	COG1525	nuclease
CN246_RS12345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CN246_RS12350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CN246_RS12360	COG0347	Belongs to the P(II) protein family
CN246_RS12365	COG0347	Belongs to the P(II) protein family
CN246_RS12380	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CN246_RS12390	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CN246_RS12405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CN246_RS12410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CN246_RS12460	COG2207	Transcriptional regulator
CN246_RS12460	COG4753	response regulator
CN246_RS12485	COG1172	Belongs to the binding-protein-dependent transport system permease family
CN246_RS12500	COG4372	Transposase
CN246_RS12525	COG1216	Glycosyl transferase, family 2
CN246_RS12580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CN246_RS12590	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CN246_RS12615	COG1732	Glycine betaine
CN246_RS12625	COG1174	glycine betaine transport
CN246_RS12630	COG1125	glycine betaine transport
CN246_RS12630	COG0517	IMP dehydrogenase activity
CN246_RS12665	COG4372	Transposase
CN246_RS12680	COG3546	catalase activity
CN246_RS12715	COG0542	response to heat
CN246_RS12725	COG1621	beta-fructofuranosidase activity
CN246_RS12730	COG3279	Response regulator of the LytR AlgR family
CN246_RS12740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CN246_RS12745	COG0482	sulfurtransferase activity
CN246_RS12785	COG1396	sequence-specific DNA binding
CN246_RS12810	COG0395	ABC-type sugar transport system, permease component
CN246_RS12820	COG3842	ATPase activity
CN246_RS12830	COG4978	Transcriptional regulator
CN246_RS12830	COG0789	Transcriptional regulator
CN246_RS12840	COG0347	Belongs to the P(II) protein family
CN246_RS12850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CN246_RS12855	COG1116	anion transmembrane transporter activity
CN246_RS12865	COG3665	Urea carboxylase-associated protein
CN246_RS12870	COG0439	Biotin carboxylase
CN246_RS12885	COG0463	Glycosyl transferase, family 2
CN246_RS12905	COG4372	Transposase
CN246_RS12965	COG2002	toxin-antitoxin pair type II binding
CN246_RS13025	COG0629	single-stranded DNA binding
CN246_RS13045	COG1192	Involved in chromosome partitioning
CN246_RS13050	COG1475	DNA binding
CN246_RS13055	COG2088	sporulation resulting in formation of a cellular spore
CN246_RS13155	COG4372	Transposase
CN246_RS13290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CN246_RS13305	COG1328	CTP reductase activity
CN246_RS13305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CN246_RS13310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CN246_RS13315	COG1132	(ABC) transporter
CN246_RS13320	COG1132	(ABC) transporter
CN246_RS13350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CN246_RS13395	COG2088	sporulation resulting in formation of a cellular spore
CN246_RS13400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CN246_RS13405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CN246_RS13420	COG0723	plastoquinol--plastocyanin reductase activity
CN246_RS13420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CN246_RS13425	COG4251	negative regulation of phosphorylation
CN246_RS13425	COG2203	Gaf domain
CN246_RS13425	COG5001	Diguanylate cyclase
CN246_RS13425	COG3706	GGDEF domain
CN246_RS13430	COG0360	Binds together with S18 to 16S ribosomal RNA
CN246_RS13435	COG0629	single-stranded DNA binding
CN246_RS13440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CN246_RS13455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CN246_RS13475	COG0463	Glycosyl transferase, family 2
CN246_RS13490	COG2195	Cleaves the N-terminal amino acid of tripeptides
CN246_RS13495	COG0463	Glycosyl transferase, family 2
CN246_RS13500	COG0745	RESPONSE REGULATOR receiver
CN246_RS13505	COG5002	protein histidine kinase activity
CN246_RS13515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CN246_RS13520	COG0740	serine-type endopeptidase activity
CN246_RS13525	COG0544	peptidyl-prolyl cis-trans isomerase activity
CN246_RS13545	COG0697	spore germination
CN246_RS13555	COG1360	Flagellar Motor Protein
CN246_RS13575	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CN246_RS13585	COG2201	protein-glutamate methylesterase activity
CN246_RS13595	COG0835	chemotaxis
CN246_RS13600	COG0643	Histidine kinase
CN246_RS13600	COG2198	Histidine kinase
CN246_RS13605	COG0463	Glycosyl transferase, family 2
CN246_RS13605	COG0457	Tetratricopeptide repeat
CN246_RS13615	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CN246_RS13620	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CN246_RS13650	COG4786	Flagellar basal body rod
CN246_RS13655	COG4786	Flagellar basal body rod
CN246_RS13665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CN246_RS13670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CN246_RS13675	COG1684	flagellar biosynthetic protein fliR
CN246_RS13680	COG1987	bacterial-type flagellum assembly
CN246_RS13685	COG1338	Plays a role in the flagellum-specific transport system
CN246_RS13695	COG2201	protein-glutamate methylesterase activity
CN246_RS13700	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CN246_RS13700	COG1776	CheC inhibitor of MCP methylation
CN246_RS13705	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CN246_RS13715	COG1582	Flagellar protein (FlbD)
CN246_RS13720	COG4786	Flagellar basal body rod
CN246_RS13745	COG1157	protein secretion by the type III secretion system
CN246_RS13750	COG1317	bacterial-type flagellum organization
CN246_RS13760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CN246_RS13775	COG1558	bacterial-type flagellum-dependent cell motility
CN246_RS13780	COG1815	bacterial-type flagellum-dependent cell motility
CN246_RS13790	COG0583	DNA-binding transcription factor activity
CN246_RS13795	COG0477	Major facilitator Superfamily
CN246_RS13805	COG0697	spore germination
CN246_RS13815	COG0058	SHG alpha-glucan phosphorylase activity
CN246_RS13825	COG1609	Transcriptional regulator
CN246_RS13865	COG0084	hydrolase, TatD family'
CN246_RS13880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CN246_RS13885	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CN246_RS13895	COG5002	protein histidine kinase activity
CN246_RS13910	COG1595	DNA-templated transcription, initiation
CN246_RS13920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CN246_RS13930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CN246_RS13940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CN246_RS13945	COG2264	protein methyltransferase activity
CN246_RS14000	COG0396	ATPase activity
CN246_RS14005	COG0719	Fe-S assembly protein
CN246_RS14010	COG0719	Fe-S assembly protein
CN246_RS14015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CN246_RS14020	COG0822	iron-sulfur transferase activity
CN246_RS14050	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CN246_RS14060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CN246_RS14080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CN246_RS14090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CN246_RS14095	COG0825	malonyl-CoA metabolic process
CN246_RS14100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CN246_RS14105	COG0439	Biotin carboxylase
CN246_RS14110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CN246_RS14115	COG0511	ligase activity, forming carbon-carbon bonds
CN246_RS14120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CN246_RS14130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CN246_RS14140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CN246_RS14145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CN246_RS14150	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CN246_RS14155	COG0287	Prephenate dehydrogenase
CN246_RS14165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CN246_RS14170	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CN246_RS14175	COG0077	Prephenate dehydratase
CN246_RS14175	COG1605	Chorismate mutase
CN246_RS14180	COG0148	phosphopyruvate hydratase activity
CN246_RS14190	COG0489	protein tyrosine kinase activity
CN246_RS14195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CN246_RS14200	COG0488	(ABC) transporter
CN246_RS14205	COG0829	nickel cation binding
CN246_RS14210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CN246_RS14220	COG0804	urea catabolic process
CN246_RS14225	COG0832	Belongs to the urease beta subunit family
CN246_RS14225	COG0831	urea catabolic process
CN246_RS14230	COG0831	urea catabolic process
CN246_RS14240	COG3858	chitin binding
CN246_RS14240	COG1388	LysM domain
CN246_RS14250	COG0698	ribose 5-phosphate isomerase
CN246_RS14255	COG0653	protein targeting
CN246_RS14260	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CN246_RS14265	COG0248	Ppx GppA phosphatase
CN246_RS14270	COG2323	membrane
CN246_RS14280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CN246_RS14295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CN246_RS14300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CN246_RS14315	COG2706	6-phosphogluconolactonase activity
CN246_RS14325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CN246_RS14335	COG1346	cytolysis
CN246_RS14360	COG1607	acyl-coa hydrolase
CN246_RS14365	COG0067	glutamate synthase
CN246_RS14365	COG0070	glutamate synthase
CN246_RS14365	COG0069	glutamate synthase activity
CN246_RS14370	COG0493	'glutamate synthase
CN246_RS14385	COG2033	superoxide reductase activity
CN246_RS14390	COG1914	H( )-stimulated, divalent metal cation uptake system
CN246_RS14400	COG1902	pentaerythritol trinitrate reductase activity
CN246_RS14405	COG0191	fructose-bisphosphate aldolase activity
CN246_RS14420	COG1573	uracil-dna glycosylase
CN246_RS14425	COG0280	phosphate acetyltransferase
CN246_RS14430	COG4869	propanediol catabolic process
CN246_RS14450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CN246_RS14455	COG0009	L-threonylcarbamoyladenylate synthase
CN246_RS14460	COG0237	dephospho-CoA kinase activity
CN246_RS14465	COG0741	lytic transglycosylase activity
CN246_RS14465	COG1196	nuclear chromosome segregation
CN246_RS14465	COG0739	heme binding
CN246_RS14470	COG1362	aminopeptidase activity
CN246_RS14485	COG3706	GGDEF domain
CN246_RS14495	COG2217	Heavy metal translocating P-type atpase
CN246_RS14500	COG0640	Transcriptional regulator
CN246_RS14510	COG4451	ribulose bisphosphate carboxylase, small
CN246_RS14510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CN246_RS14525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CN246_RS14535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CN246_RS14535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CN246_RS14535	COG1013	pyruvate-flavodoxin oxidoreductase activity
CN246_RS14535	COG0674	pyruvate-flavodoxin oxidoreductase activity
CN246_RS14540	COG1253	flavin adenine dinucleotide binding
CN246_RS14545	COG0708	Exodeoxyribonuclease III
CN246_RS14550	COG5434	Belongs to the glycosyl hydrolase 28 family
CN246_RS14550	COG4632	Exopolysaccharide biosynthesis protein
CN246_RS14560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CN246_RS14575	COG0613	PHP domain protein
CN246_RS14590	COG1664	Polymer-forming cytoskeletal
CN246_RS14595	COG0789	Transcriptional regulator
CN246_RS14600	COG1309	transcriptional regulator
CN246_RS14605	COG1511	domain protein
CN246_RS14630	COG4932	domain protein
CN246_RS14630	COG1388	LysM domain
CN246_RS14635	COG3279	Response regulator of the LytR AlgR family
CN246_RS14640	COG2213	PTS system mannitol-specific
CN246_RS14645	COG3711	transcriptional antiterminator
CN246_RS14655	COG0246	Mannitol dehydrogenase
CN246_RS14675	COG0534	Mate efflux family protein
CN246_RS14685	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CN246_RS14690	COG0346	lactoylglutathione lyase activity
CN246_RS14705	COG0083	homoserine kinase activity
CN246_RS14715	COG4492	Belongs to the UPF0735 family
CN246_RS14720	COG0628	permease
CN246_RS14735	COG0386	Belongs to the glutathione peroxidase family
CN246_RS14745	COG0717	Belongs to the dCTP deaminase family
CN246_RS14805	COG0196	riboflavin kinase activity
CN246_RS14815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CN246_RS14825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CN246_RS14835	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CN246_RS14840	COG0195	Participates in both transcription termination and antitermination
CN246_RS14845	COG0779	Required for maturation of 30S ribosomal subunits
CN246_RS14860	COG1475	DNA binding
CN246_RS14865	COG1192	Involved in chromosome partitioning
CN246_RS14870	COG1475	DNA binding
CN246_RS14875	COG0357	Ribosomal RNA small subunit methyltransferase G
CN246_RS14880	COG0445	tRNA wobble uridine modification
CN246_RS14885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CN246_RS14890	COG1847	R3H domain protein
CN246_RS14895	COG0706	membrane insertase activity
CN246_RS14900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CN246_RS14905	COG0594	ribonuclease P activity
CN246_RS14910	COG0230	Belongs to the bacterial ribosomal protein bL34 family