locus-tag	class	description
FRE64_RS00025	COG2239	Acts as a magnesium transporter
FRE64_RS00035	COG0542	response to heat
FRE64_RS00040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FRE64_RS00045	COG0193	aminoacyl-tRNA hydrolase activity
FRE64_RS00055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FRE64_RS00060	COG1115	amino acid carrier protein
FRE64_RS00070	COG4581	dead DEAH box helicase
FRE64_RS00075	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FRE64_RS00085	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FRE64_RS00125	COG5002	protein histidine kinase activity
FRE64_RS00130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRE64_RS00130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FRE64_RS00150	COG0463	Glycosyl transferase, family 2
FRE64_RS00200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRE64_RS00210	COG0426	domain, Protein
FRE64_RS00210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRE64_RS00215	COG0484	heat shock protein binding
FRE64_RS00220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FRE64_RS00235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FRE64_RS00255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FRE64_RS00260	COG0686	Belongs to the AlaDH PNT family
FRE64_RS00270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRE64_RS00275	COG1191	sigma factor activity
FRE64_RS00280	COG1573	uracil-dna glycosylase
FRE64_RS00290	COG0142	geranyltranstransferase activity
FRE64_RS00295	COG3932	Exopolysaccharide synthesis, ExoD
FRE64_RS00300	COG0681	Belongs to the peptidase S26 family
FRE64_RS00305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FRE64_RS00320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FRE64_RS00325	COG3046	protein related to deoxyribodipyrimidine photolyase
FRE64_RS00330	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FRE64_RS00340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FRE64_RS00345	COG0631	protein serine/threonine phosphatase activity
FRE64_RS00350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRE64_RS00355	COG3937	granule-associated protein
FRE64_RS00360	COG2267	carboxylic ester hydrolase activity
FRE64_RS00375	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FRE64_RS00395	COG0107	imidazoleglycerol-phosphate synthase activity
FRE64_RS00400	COG2255	four-way junction helicase activity
FRE64_RS00405	COG1053	succinate dehydrogenase
FRE64_RS00425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRE64_RS00430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRE64_RS00435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRE64_RS00450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRE64_RS00465	COG0445	tRNA wobble uridine modification
FRE64_RS00475	COG0305	Participates in initiation and elongation during chromosome replication
FRE64_RS00475	COG0305	Participates in initiation and elongation during chromosome replication
FRE64_RS00475	COG1372	Participates in initiation and elongation during chromosome replication
FRE64_RS00475	COG1372	Participates in initiation and elongation during chromosome replication
FRE64_RS00485	COG0156	8-amino-7-oxononanoate synthase activity
FRE64_RS00495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRE64_RS00510	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FRE64_RS00525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FRE64_RS00530	COG0859	PFAM glycosyl transferase family 9
FRE64_RS00535	COG0484	heat shock protein binding
FRE64_RS00545	COG1596	polysaccharide export
FRE64_RS00580	COG0440	acetolactate synthase activity
FRE64_RS00585	COG0247	lactate metabolic process
FRE64_RS00590	COG0277	FAD linked oxidase domain protein
FRE64_RS00595	COG0746	molybdenum cofactor guanylyltransferase activity
FRE64_RS00620	COG1042	CoA-binding domain protein
FRE64_RS00620	COG0045	succinate-CoA ligase (ADP-forming) activity
FRE64_RS00620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FRE64_RS00645	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FRE64_RS00660	COG3335	DDE superfamily endonuclease
FRE64_RS00670	COG0805	protein transport
FRE64_RS00675	COG2211	Major facilitator Superfamily
FRE64_RS00680	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
FRE64_RS00720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FRE64_RS00725	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FRE64_RS00730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FRE64_RS00735	COG1331	Highly conserved protein containing a thioredoxin domain
FRE64_RS00745	COG0612	Peptidase, M16
FRE64_RS00755	COG0589	response to stress
FRE64_RS00755	COG0475	glutathione-regulated potassium exporter activity
FRE64_RS00760	COG1217	gtp-binding protein TYPA
FRE64_RS00765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRE64_RS00770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FRE64_RS00775	COG1194	a g-specific adenine glycosylase
FRE64_RS00790	COG0189	ligase activity
FRE64_RS00795	COG0189	ligase activity
FRE64_RS00795	COG4067	protein conserved in archaea
FRE64_RS00825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FRE64_RS00830	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FRE64_RS00840	COG2081	HI0933 family
FRE64_RS00845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRE64_RS00880	COG0517	IMP dehydrogenase activity
FRE64_RS00880	COG0516	GMP reductase activity
FRE64_RS00885	COG0303	'Molybdopterin
FRE64_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FRE64_RS00900	COG1160	GTP binding
FRE64_RS00905	COG0629	single-stranded DNA binding
FRE64_RS00925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRE64_RS00930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FRE64_RS00935	COG0601	transmembrane transport
FRE64_RS00950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FRE64_RS00965	COG1131	(ABC) transporter
FRE64_RS00970	COG3659	wide pore channel activity
FRE64_RS00985	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FRE64_RS00990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRE64_RS00995	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FRE64_RS01000	COG2080	2 iron, 2 sulfur cluster binding
FRE64_RS01050	COG1091	dTDP-4-dehydrorhamnose reductase activity
FRE64_RS01095	COG0463	Glycosyl transferase, family 2
FRE64_RS01150	COG2274	protein secretion by the type I secretion system
FRE64_RS01170	COG4399	Belongs to the UPF0754 family
FRE64_RS01175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FRE64_RS01175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FRE64_RS01180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FRE64_RS01190	COG0701	Predicted permease
FRE64_RS01205	COG1376	ErfK ybiS ycfS ynhG family protein
FRE64_RS01215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRE64_RS01225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FRE64_RS01230	COG0271	Belongs to the BolA IbaG family
FRE64_RS01240	COG2205	protein histidine kinase activity
FRE64_RS01245	COG1595	DNA-templated transcription, initiation
FRE64_RS01255	COG0352	thiamine-phosphate diphosphorylase activity
FRE64_RS01270	COG2027	D-alanyl-D-alanine carboxypeptidase
FRE64_RS01275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRE64_RS01300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FRE64_RS01305	COG1882	Formate acetyltransferase
FRE64_RS01310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FRE64_RS01315	COG1012	belongs to the aldehyde dehydrogenase family
FRE64_RS01315	COG1454	alcohol dehydrogenase
FRE64_RS01320	COG0572	uridine kinase
FRE64_RS01340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRE64_RS01340	COG0758	DNA mediated transformation
FRE64_RS01350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FRE64_RS01365	COG0385	Bile acid
FRE64_RS01375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FRE64_RS01380	COG1077	Cell shape determining protein MreB Mrl
FRE64_RS01385	COG0629	single-stranded DNA binding
FRE64_RS01395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRE64_RS01400	COG1797	cobyrinic acid a,c-diamide synthase activity
FRE64_RS01405	COG0017	Asparaginyl-tRNA synthetase
FRE64_RS01410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FRE64_RS01420	COG3344	reverse transcriptase
FRE64_RS01440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FRE64_RS01445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRE64_RS01450	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FRE64_RS01455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FRE64_RS01460	COG1254	Belongs to the acylphosphatase family
FRE64_RS01465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRE64_RS01475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRE64_RS01480	COG0515	serine threonine protein kinase
FRE64_RS01480	COG3266	domain, Protein
FRE64_RS01485	COG4991	sh3 domain protein
FRE64_RS01485	COG3064	Membrane
FRE64_RS01485	COG0515	serine threonine protein kinase
FRE64_RS01490	COG0138	bifunctional purine biosynthesis protein purh
FRE64_RS01510	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRE64_RS01530	COG2319	Wd-40 repeat
FRE64_RS01530	COG1672	PFAM Archaeal ATPase
FRE64_RS01535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRE64_RS01535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRE64_RS01560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FRE64_RS01565	COG0830	nickel cation binding
FRE64_RS01570	COG0589	response to stress
FRE64_RS01575	COG0242	peptide deformylase activity
FRE64_RS01590	COG3956	TIGRFAM MazG family protein
FRE64_RS01610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FRE64_RS01615	COG0616	signal peptide processing
FRE64_RS01620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRE64_RS01640	COG0166	Belongs to the GPI family
FRE64_RS01645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRE64_RS01665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FRE64_RS01670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRE64_RS01675	COG0336	Belongs to the RNA methyltransferase TrmD family
FRE64_RS01680	COG2205	protein histidine kinase activity
FRE64_RS01685	COG0745	RESPONSE REGULATOR receiver
FRE64_RS01695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRE64_RS01710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRE64_RS01720	COG0012	GTP binding
FRE64_RS01725	COG0673	inositol 2-dehydrogenase activity
FRE64_RS01730	COG1136	(ABC) transporter
FRE64_RS01730	COG0577	efflux transmembrane transporter activity
FRE64_RS01760	COG0135	phosphoribosylanthranilate isomerase activity
FRE64_RS01770	COG0022	dehydrogenase e1 component
FRE64_RS01770	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRE64_RS01775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRE64_RS01780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRE64_RS01795	COG0442	prolyl-tRNA aminoacylation
FRE64_RS01810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRE64_RS01845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRE64_RS01855	COG0529	Catalyzes the synthesis of activated sulfate
FRE64_RS01860	COG1132	(ABC) transporter
FRE64_RS01865	COG0587	DNA-directed DNA polymerase activity
FRE64_RS01880	COG0501	Belongs to the peptidase M48B family
FRE64_RS01890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRE64_RS01900	COG0390	transport system, permease component
FRE64_RS01910	COG0471	metal ion transport
FRE64_RS01910	COG3273	potassium ion transport
FRE64_RS01915	COG0606	chelatase, subunit chli
FRE64_RS01945	COG0157	Belongs to the NadC ModD family
FRE64_RS01955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FRE64_RS01960	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FRE64_RS01970	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FRE64_RS01980	COG0542	response to heat
FRE64_RS01995	COG0733	neurotransmitter:sodium symporter activity
FRE64_RS02000	COG0514	ATP-dependent DNA helicase (RecQ)
FRE64_RS02030	COG4948	Mandelate Racemase Muconate Lactonizing
FRE64_RS02035	COG0318	PFAM AMP-dependent synthetase and ligase
FRE64_RS02065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRE64_RS02075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRE64_RS02085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRE64_RS02090	COG0783	Belongs to the Dps family
FRE64_RS02100	COG1045	serine acetyltransferase
FRE64_RS02105	COG1433	Dinitrogenase iron-molybdenum cofactor
FRE64_RS02105	COG0535	radical SAM domain protein
FRE64_RS02115	COG1104	cysteine desulfurase activity
FRE64_RS02125	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FRE64_RS02130	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FRE64_RS02140	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FRE64_RS02145	COG5554	nitrogen fixation
FRE64_RS02150	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FRE64_RS02155	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FRE64_RS02195	COG0725	ABC transporter, periplasmic molybdate-binding protein
FRE64_RS02205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRE64_RS02215	COG2226	methyltransferase
FRE64_RS02220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRE64_RS02225	COG0719	Fe-S assembly protein
FRE64_RS02230	COG0396	ATPase activity
FRE64_RS02235	COG0719	Fe-S assembly protein
FRE64_RS02255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRE64_RS02260	COG1234	tRNA 3'-trailer cleavage
FRE64_RS02270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FRE64_RS02300	COG0670	Belongs to the BI1 family
FRE64_RS02315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FRE64_RS02325	COG4191	Histidine kinase
FRE64_RS02345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRE64_RS02355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRE64_RS02360	COG0513	Belongs to the DEAD box helicase family
FRE64_RS02370	COG0640	Transcriptional regulator
FRE64_RS02415	COG1615	UPF0182 protein
FRE64_RS02420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRE64_RS02425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FRE64_RS02430	COG0416	fatty acid biosynthetic process
FRE64_RS02440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRE64_RS02440	COG2022	thiamine diphosphate biosynthetic process
FRE64_RS02460	COG0018	arginyl-trna synthetase
FRE64_RS02500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRE64_RS02520	COG1104	cysteine desulfurase activity
FRE64_RS02540	COG0419	ATPase involved in DNA repair
FRE64_RS02545	COG0840	transmembrane signaling receptor activity
FRE64_RS02610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRE64_RS02620	COG0574	Belongs to the PEP-utilizing enzyme family
FRE64_RS02620	COG3848	Pyruvate phosphate dikinase
FRE64_RS02625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FRE64_RS02635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRE64_RS02650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRE64_RS02650	COG0072	phenylalanine-tRNA ligase activity
FRE64_RS02655	COG1357	PFAM Pentapeptide repeats (8 copies)
FRE64_RS02655	COG0515	serine threonine protein kinase
FRE64_RS02660	COG2217	Heavy metal translocating P-type atpase
FRE64_RS02680	COG1169	isochorismate synthase
FRE64_RS02685	COG1575	Belongs to the MenA family. Type 1 subfamily
FRE64_RS02700	COG0681	Belongs to the peptidase S26 family
FRE64_RS02705	COG0516	GMP reductase activity
FRE64_RS02720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRE64_RS02730	COG1940	carbohydrate kinase activity
FRE64_RS02740	COG2814	Major facilitator Superfamily
FRE64_RS02745	COG1136	(ABC) transporter
FRE64_RS02750	COG0275	rRNA processing
FRE64_RS02765	COG5002	protein histidine kinase activity
FRE64_RS02775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRE64_RS02780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FRE64_RS02785	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FRE64_RS02810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRE64_RS02820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FRE64_RS02860	COG4785	May be involved in cell division
FRE64_RS02875	COG1121	(ABC) transporter
FRE64_RS02890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRE64_RS02895	COG2226	methyltransferase
FRE64_RS02905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FRE64_RS02915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FRE64_RS02930	COG0482	sulfurtransferase activity
FRE64_RS02935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FRE64_RS02940	COG0513	Belongs to the DEAD box helicase family
FRE64_RS02965	COG0481	GTPase activity
FRE64_RS03000	COG0667	Aldo Keto reductase
FRE64_RS03110	COG1132	(ABC) transporter
FRE64_RS03120	COG0515	serine threonine protein kinase
FRE64_RS03120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRE64_RS03125	COG0121	glutamine amidotransferase
FRE64_RS03130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FRE64_RS03135	COG2894	cell division
FRE64_RS03140	COG0850	regulation of cytokinetic process
FRE64_RS03195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRE64_RS03195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FRE64_RS03200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FRE64_RS03220	COG2814	Major facilitator Superfamily
FRE64_RS03255	COG1253	flavin adenine dinucleotide binding
FRE64_RS03315	COG2217	Heavy metal translocating P-type atpase
FRE64_RS03335	COG0004	ammonium transporteR
FRE64_RS03340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FRE64_RS03345	COG2267	carboxylic ester hydrolase activity
FRE64_RS03350	COG0561	phosphatase activity
FRE64_RS03355	COG1127	ABC transporter
FRE64_RS03365	COG0109	protoheme IX farnesyltransferase activity
FRE64_RS03375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRE64_RS03380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRE64_RS03385	COG1845	cytochrome c oxidase, subunit III
FRE64_RS03405	COG2082	Precorrin-8x methylmutase
FRE64_RS03420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRE64_RS03440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRE64_RS03450	COG0704	Plays a role in the regulation of phosphate uptake
FRE64_RS03475	COG4221	oxidoreductase activity
FRE64_RS03480	COG4175	Glycine betaine
FRE64_RS03480	COG3448	diguanylate cyclase activity
FRE64_RS03485	COG4176	ABC-type proline glycine betaine transport system permease component
FRE64_RS03495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FRE64_RS03505	COG0523	cobalamin synthesis protein
FRE64_RS03510	COG2113	Glycine betaine
FRE64_RS03515	COG0215	cysteine-tRNA ligase activity
FRE64_RS03540	COG0438	transferase activity, transferring glycosyl groups
FRE64_RS03545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRE64_RS03550	COG0583	DNA-binding transcription factor activity
FRE64_RS03560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRE64_RS03565	COG0484	heat shock protein binding
FRE64_RS03570	COG0357	Ribosomal RNA small subunit methyltransferase G
FRE64_RS03610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FRE64_RS03620	COG2091	lysine biosynthetic process via aminoadipic acid
FRE64_RS03625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FRE64_RS03630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRE64_RS03640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRE64_RS03645	COG0463	Glycosyl transferase, family 2
FRE64_RS03650	COG0438	transferase activity, transferring glycosyl groups
FRE64_RS03720	COG0438	transferase activity, transferring glycosyl groups
FRE64_RS03755	COG1132	(ABC) transporter
FRE64_RS03760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRE64_RS03775	COG0438	transferase activity, transferring glycosyl groups
FRE64_RS03785	COG2319	Wd-40 repeat
FRE64_RS03785	COG3903	Transcriptional regulator
FRE64_RS03810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRE64_RS03815	COG5001	Diguanylate cyclase
FRE64_RS03820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FRE64_RS03825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRE64_RS03830	COG0837	glucose binding
FRE64_RS03840	COG2203	Gaf domain
FRE64_RS03840	COG3706	GGDEF domain
FRE64_RS03840	COG4251	negative regulation of phosphorylation
FRE64_RS03840	COG5001	Diguanylate cyclase
FRE64_RS03850	COG1283	sodium-dependent phosphate transmembrane transporter activity
FRE64_RS03860	COG1160	GTP binding
FRE64_RS03875	COG0745	RESPONSE REGULATOR receiver
FRE64_RS03880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FRE64_RS03885	COG0528	UMP kinase activity
FRE64_RS03890	COG0233	cytoplasmic translational termination
FRE64_RS03895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRE64_RS03910	COG0538	isocitrate dehydrogenase activity
FRE64_RS03915	COG0546	phosphoglycolate phosphatase activity
FRE64_RS03930	COG0799	negative regulation of ribosome biogenesis
FRE64_RS03935	COG1713	HD superfamily hydrolase involved in NAD metabolism
FRE64_RS03935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FRE64_RS03950	COG0124	histidyl-tRNA synthetase
FRE64_RS03955	COG3659	wide pore channel activity
FRE64_RS03970	COG0351	phosphomethylpyrimidine kinase
FRE64_RS03975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FRE64_RS03985	COG0793	Belongs to the peptidase S41A family
FRE64_RS04000	COG0113	porphobilinogen synthase activity
FRE64_RS04015	COG0484	heat shock protein binding
FRE64_RS04030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FRE64_RS04035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRE64_RS04040	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FRE64_RS04045	COG0019	diaminopimelate decarboxylase activity
FRE64_RS04050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FRE64_RS04055	COG2188	Transcriptional regulator
FRE64_RS04065	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRE64_RS04080	COG2084	Dehydrogenase
FRE64_RS04085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRE64_RS04085	COG0574	Belongs to the PEP-utilizing enzyme family
FRE64_RS04135	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FRE64_RS04145	COG1840	ABC-type Fe3 transport system, periplasmic component
FRE64_RS04150	COG1840	ABC-type Fe3 transport system, periplasmic component
FRE64_RS04155	COG1178	ABC-type Fe3 transport system permease component
FRE64_RS04160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRE64_RS04205	COG0602	queuosine metabolic process
FRE64_RS04215	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FRE64_RS04230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRE64_RS04235	COG1691	(AIR) carboxylase
FRE64_RS04240	COG0747	negative chemotaxis
FRE64_RS04260	COG0037	tRNA processing
FRE64_RS04270	COG0360	Binds together with S18 to 16S ribosomal RNA
FRE64_RS04280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FRE64_RS04290	COG1122	ATPase activity
FRE64_RS04300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS04305	COG0436	Aminotransferase
FRE64_RS04310	COG0371	Dehydrogenase
FRE64_RS04325	COG0772	Belongs to the SEDS family
FRE64_RS04345	COG0745	RESPONSE REGULATOR receiver
FRE64_RS04355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FRE64_RS04360	COG1047	Peptidyl-prolyl cis-trans
FRE64_RS04365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRE64_RS04370	COG2226	methyltransferase
FRE64_RS04390	COG0625	glutathione transferase activity
FRE64_RS04395	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FRE64_RS04405	COG0359	binds to the 23S rRNA
FRE64_RS04410	COG0004	ammonium transporteR
FRE64_RS04430	COG0025	NhaP-type Na H and K H
FRE64_RS04455	COG4636	protein conserved in cyanobacteria
FRE64_RS04490	COG3335	DDE superfamily endonuclease
FRE64_RS04530	COG0697	spore germination
FRE64_RS04535	COG0714	Associated with various cellular activities
FRE64_RS04540	COG0196	riboflavin kinase activity
FRE64_RS04560	COG1316	TRANSCRIPTIONal
FRE64_RS04565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FRE64_RS04570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FRE64_RS04610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FRE64_RS04615	COG0500	methyltransferase
FRE64_RS04620	COG1181	Belongs to the D-alanine--D-alanine ligase family
FRE64_RS04645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRE64_RS04650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FRE64_RS04655	COG1473	amidohydrolase
FRE64_RS04660	COG0747	negative chemotaxis
FRE64_RS04685	COG4969	Belongs to the N-Me-Phe pilin family
FRE64_RS04700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRE64_RS04705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRE64_RS04745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FRE64_RS04760	COG4636	protein conserved in cyanobacteria
FRE64_RS04765	COG0515	serine threonine protein kinase
FRE64_RS04770	COG2890	protein-(glutamine-N5) methyltransferase activity
FRE64_RS04780	COG2124	cytochrome p450
FRE64_RS04820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRE64_RS04825	COG4106	trans-aconitate 2-methyltransferase activity
FRE64_RS04855	COG3639	organic phosphonate transmembrane transporter activity
FRE64_RS04860	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FRE64_RS04880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FRE64_RS04880	COG0284	orotidine-5'-phosphate decarboxylase activity
FRE64_RS04885	COG0793	Belongs to the peptidase S41A family
FRE64_RS04895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRE64_RS04900	COG5398	heme oxygenase
FRE64_RS04905	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
FRE64_RS04910	COG0675	Transposase, IS605 OrfB family
FRE64_RS04945	COG2217	Heavy metal translocating P-type atpase
FRE64_RS04955	COG1032	radical SAM domain protein
FRE64_RS04970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FRE64_RS04975	COG1429	ligase activity, forming nitrogen-metal bonds
FRE64_RS05025	COG2274	protein secretion by the type I secretion system
FRE64_RS05050	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
FRE64_RS05055	COG2124	cytochrome p450
FRE64_RS05060	COG1733	regulation of RNA biosynthetic process
FRE64_RS05065	COG1741	Belongs to the pirin family
FRE64_RS05070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FRE64_RS05075	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRE64_RS05105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FRE64_RS05115	COG0343	queuine tRNA-ribosyltransferase activity
FRE64_RS05125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FRE64_RS05165	COG0436	Aminotransferase
FRE64_RS05170	COG3118	belongs to the thioredoxin family
FRE64_RS05175	COG1842	Phage shock protein A
FRE64_RS05185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRE64_RS05215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRE64_RS05225	COG0438	transferase activity, transferring glycosyl groups
FRE64_RS05235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FRE64_RS05240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRE64_RS05250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FRE64_RS05255	COG0540	Belongs to the ATCase OTCase family
FRE64_RS05275	COG1027	Aspartate ammonia-lyase
FRE64_RS05290	COG0784	Response regulator, receiver
FRE64_RS05290	COG2198	Histidine kinase
FRE64_RS05290	COG0643	Histidine kinase
FRE64_RS05300	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FRE64_RS05310	COG1252	NADH dehydrogenase
FRE64_RS05325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FRE64_RS05330	COG0589	response to stress
FRE64_RS05330	COG0475	glutathione-regulated potassium exporter activity
FRE64_RS05335	COG3588	fructose-bisphosphate aldolase
FRE64_RS05340	COG1214	PFAM Peptidase M22, glycoprotease
FRE64_RS05345	COG1090	epimerase
FRE64_RS05370	COG0525	valine-tRNA ligase activity
FRE64_RS05405	COG0003	Pfam Anion-transporting ATPase
FRE64_RS05415	COG1966	Carbon starvation protein
FRE64_RS05420	COG0363	glucosamine-6-phosphate deaminase activity
FRE64_RS05425	COG1716	ATPase activity
FRE64_RS05455	COG0159	tryptophan synthase activity
FRE64_RS05465	COG0460	homoserine dehydrogenase
FRE64_RS05475	COG0752	glycyl-tRNA synthetase alpha subunit
FRE64_RS05510	COG0358	DNA primase activity
FRE64_RS05575	COG0010	Belongs to the arginase family
FRE64_RS05580	COG0728	peptidoglycan biosynthetic process
FRE64_RS05590	COG1324	tolerance protein
FRE64_RS05595	COG0504	CTP synthase activity
FRE64_RS05600	COG2208	phosphoserine phosphatase activity
FRE64_RS05610	COG1333	cytochrome c biogenesis protein
FRE64_RS05615	COG2113	Glycine betaine
FRE64_RS05620	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FRE64_RS05635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRE64_RS05635	COG2022	thiamine diphosphate biosynthetic process
FRE64_RS05640	COG2261	transglycosylase associated protein
FRE64_RS05645	COG1372	Participates in initiation and elongation during chromosome replication
FRE64_RS05645	COG0187	DNA topoisomerase II activity
FRE64_RS05650	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRE64_RS05665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FRE64_RS05670	COG0347	Belongs to the P(II) protein family
FRE64_RS05675	COG0473	3-isopropylmalate dehydrogenase activity
FRE64_RS05680	COG5002	protein histidine kinase activity
FRE64_RS05695	COG0745	RESPONSE REGULATOR receiver
FRE64_RS05700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRE64_RS05720	COG0406	alpha-ribazole phosphatase activity
FRE64_RS05740	COG1131	(ABC) transporter
FRE64_RS05750	COG0222	ribosome binding
FRE64_RS05755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRE64_RS05760	COG0081	regulation of translation
FRE64_RS05765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRE64_RS05770	COG0250	Participates in transcription elongation, termination and antitermination
FRE64_RS05775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FRE64_RS05785	COG0335	large ribosomal subunit rRNA binding
FRE64_RS05790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRE64_RS05815	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FRE64_RS05825	COG1615	UPF0182 protein
FRE64_RS05830	COG4636	protein conserved in cyanobacteria
FRE64_RS05835	COG1620	l-lactate permease
FRE64_RS05840	COG0723	plastoquinol--plastocyanin reductase activity
FRE64_RS05850	COG1131	(ABC) transporter
FRE64_RS05865	COG0793	Belongs to the peptidase S41A family
FRE64_RS05890	COG1131	(ABC) transporter
FRE64_RS05910	COG0735	belongs to the Fur family
FRE64_RS05915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRE64_RS05950	COG1116	anion transmembrane transporter activity
FRE64_RS05955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRE64_RS05970	COG0375	protein maturation
FRE64_RS05975	COG0010	Belongs to the arginase family
FRE64_RS06000	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
FRE64_RS06005	COG1116	anion transmembrane transporter activity
FRE64_RS06005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRE64_RS06010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRE64_RS06015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRE64_RS06020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRE64_RS06030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FRE64_RS06035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRE64_RS06045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRE64_RS06050	COG0840	transmembrane signaling receptor activity
FRE64_RS06070	COG0134	indole-3-glycerol-phosphate synthase activity
FRE64_RS06085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FRE64_RS06100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FRE64_RS06110	COG2052	Domain of unknown function (DUF370)
FRE64_RS06115	COG0194	GDP metabolic process
FRE64_RS06120	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FRE64_RS06125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRE64_RS06165	COG4636	protein conserved in cyanobacteria
FRE64_RS06175	COG1049	propionate catabolic process, 2-methylcitrate cycle
FRE64_RS06180	COG0557	exoribonuclease II activity
FRE64_RS06190	COG0740	serine-type endopeptidase activity
FRE64_RS06195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FRE64_RS06200	COG0590	tRNA wobble adenosine to inosine editing
FRE64_RS06220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRE64_RS06225	COG0750	zinc metalloprotease
FRE64_RS06230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRE64_RS06240	COG2264	protein methyltransferase activity
FRE64_RS06245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRE64_RS06265	COG0277	FAD linked oxidase domain protein
FRE64_RS06315	COG0243	molybdopterin cofactor binding
FRE64_RS06320	COG2223	nitrite transmembrane transporter activity
FRE64_RS06340	COG0724	RNA recognition motif
FRE64_RS06345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FRE64_RS06365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRE64_RS06375	COG2385	sporulation resulting in formation of a cellular spore
FRE64_RS06385	COG0628	permease
FRE64_RS06395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FRE64_RS06405	COG0259	pyridoxamine-phosphate oxidase activity
FRE64_RS06420	COG1247	-acetyltransferase
FRE64_RS06435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRE64_RS06440	COG0436	Aminotransferase
FRE64_RS06475	COG1104	cysteine desulfurase activity
FRE64_RS06495	COG0751	glycine-tRNA ligase activity
FRE64_RS06500	COG0830	nickel cation binding
FRE64_RS06510	COG0829	nickel cation binding
FRE64_RS06515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FRE64_RS06520	COG0804	urea catabolic process
FRE64_RS06525	COG0832	Belongs to the urease beta subunit family
FRE64_RS06530	COG0832	Belongs to the urease beta subunit family
FRE64_RS06530	COG0831	urea catabolic process
FRE64_RS06535	COG0174	glutamine synthetase
FRE64_RS06540	COG3239	Fatty acid desaturase
FRE64_RS06555	COG0316	Belongs to the HesB IscA family
FRE64_RS06565	COG0702	epimerase
FRE64_RS06570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRE64_RS06575	COG0745	RESPONSE REGULATOR receiver
FRE64_RS06595	COG0515	serine threonine protein kinase
FRE64_RS06610	COG5002	protein histidine kinase activity
FRE64_RS06615	COG0033	Phosphoglucomutase
FRE64_RS06620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRE64_RS06625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRE64_RS06630	COG0612	Peptidase, M16
FRE64_RS06635	COG0495	leucyl-tRNA aminoacylation
FRE64_RS06650	COG2124	cytochrome p450
FRE64_RS06660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FRE64_RS06665	COG0742	ribosomal rna small subunit methyltransferase
FRE64_RS06695	COG1598	PFAM Uncharacterised protein family UPF0150
FRE64_RS06735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRE64_RS06750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FRE64_RS06755	COG0438	transferase activity, transferring glycosyl groups
FRE64_RS06765	COG1381	Involved in DNA repair and RecF pathway recombination
FRE64_RS06770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FRE64_RS06775	COG1132	(ABC) transporter
FRE64_RS06780	COG2010	Cytochrome c
FRE64_RS06790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FRE64_RS06795	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FRE64_RS06795	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FRE64_RS06800	COG0110	maltose O-acetyltransferase activity
FRE64_RS06810	COG0488	(ABC) transporter
FRE64_RS06820	COG1748	Saccharopine dehydrogenase
FRE64_RS06845	COG0052	Belongs to the universal ribosomal protein uS2 family
FRE64_RS06850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FRE64_RS06860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRE64_RS06870	COG0284	orotidine-5'-phosphate decarboxylase activity
FRE64_RS06885	COG0116	Belongs to the methyltransferase superfamily
FRE64_RS06890	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FRE64_RS06925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FRE64_RS06935	COG1115	amino acid carrier protein
FRE64_RS06940	COG0564	pseudouridine synthase activity
FRE64_RS06945	COG2046	Belongs to the sulfate adenylyltransferase family
FRE64_RS06950	COG0426	domain, Protein
FRE64_RS06950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRE64_RS06970	COG2319	Wd-40 repeat
FRE64_RS06970	COG1672	PFAM Archaeal ATPase
FRE64_RS06975	COG2045	Belongs to the ComB family
FRE64_RS06980	COG1054	Belongs to the UPF0176 family
FRE64_RS06985	COG2226	methyltransferase
FRE64_RS06995	COG0678	peroxiredoxin activity
FRE64_RS07000	COG0517	IMP dehydrogenase activity
FRE64_RS07000	COG0617	tRNA 3'-terminal CCA addition
FRE64_RS07000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FRE64_RS07015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FRE64_RS07025	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS07030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRE64_RS07035	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FRE64_RS07040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FRE64_RS07045	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
FRE64_RS07050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FRE64_RS07050	COG4451	ribulose bisphosphate carboxylase, small
FRE64_RS07060	COG1850	ribulose-bisphosphate carboxylase activity
FRE64_RS07070	COG4451	ribulose bisphosphate carboxylase, small
FRE64_RS07080	COG0310	cobalt ion transport
FRE64_RS07095	COG2814	Major facilitator Superfamily
FRE64_RS07100	COG0483	inositol monophosphate 1-phosphatase activity
FRE64_RS07115	COG0285	dihydrofolate synthase activity
FRE64_RS07125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FRE64_RS07140	COG3903	Transcriptional regulator
FRE64_RS07140	COG2319	Wd-40 repeat
FRE64_RS07160	COG1160	GTP binding
FRE64_RS07165	COG4221	oxidoreductase activity
FRE64_RS07165	COG3321	synthase
FRE64_RS07165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRE64_RS07165	COG0604	alcohol dehydrogenase
FRE64_RS07175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRE64_RS07180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRE64_RS07185	COG0572	uridine kinase
FRE64_RS07195	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FRE64_RS07225	COG1187	pseudouridine synthase activity
FRE64_RS07235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FRE64_RS07245	COG0616	signal peptide processing
FRE64_RS07250	COG0697	spore germination
FRE64_RS07260	COG0779	Required for maturation of 30S ribosomal subunits
FRE64_RS07265	COG0195	Participates in both transcription termination and antitermination
FRE64_RS07270	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRE64_RS07275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRE64_RS07280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FRE64_RS07290	COG1672	PFAM Archaeal ATPase
FRE64_RS07295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRE64_RS07305	COG0739	heme binding
FRE64_RS07315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FRE64_RS07320	COG0587	DNA-directed DNA polymerase activity
FRE64_RS07340	COG0415	Belongs to the DNA photolyase family
FRE64_RS07355	COG2202	Pas domain
FRE64_RS07355	COG2205	protein histidine kinase activity
FRE64_RS07360	COG3264	Mechanosensitive ion channel
FRE64_RS07360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FRE64_RS07365	COG0628	permease
FRE64_RS07370	COG0571	ribonuclease III activity
FRE64_RS07390	COG1193	negative regulation of DNA recombination
FRE64_RS07405	COG0589	response to stress
FRE64_RS07410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FRE64_RS07415	COG0009	L-threonylcarbamoyladenylate synthase
FRE64_RS07420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FRE64_RS07440	COG0492	ferredoxin-NADP+ reductase activity
FRE64_RS07455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRE64_RS07455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRE64_RS07465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FRE64_RS07480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FRE64_RS07505	COG4636	protein conserved in cyanobacteria
FRE64_RS07510	COG0798	PFAM Bile acid sodium symporter
FRE64_RS07515	COG0431	NADPH-dependent FMN reductase
FRE64_RS07520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRE64_RS07530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRE64_RS07535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRE64_RS07540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRE64_RS07560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FRE64_RS07585	COG1895	HEPN domain
FRE64_RS07600	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FRE64_RS07605	COG0071	Belongs to the small heat shock protein (HSP20) family
FRE64_RS07645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRE64_RS07675	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FRE64_RS07700	COG0589	response to stress
FRE64_RS07705	COG0137	argininosuccinate synthase activity
FRE64_RS07715	COG0204	Acyl-transferase
FRE64_RS07720	COG1045	serine acetyltransferase
FRE64_RS07745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FRE64_RS07745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRE64_RS07750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FRE64_RS07760	COG4243	Vitamin k epoxide reductase
FRE64_RS07765	COG1971	Probably functions as a manganese efflux pump
FRE64_RS07770	COG1971	Probably functions as a manganese efflux pump
FRE64_RS07775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRE64_RS07785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRE64_RS07795	COG1357	PFAM Pentapeptide repeats (8 copies)
FRE64_RS07805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FRE64_RS07810	COG0542	response to heat
FRE64_RS07835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FRE64_RS07850	COG0589	response to stress
FRE64_RS07860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRE64_RS07865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRE64_RS07880	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FRE64_RS07895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRE64_RS07895	COG1017	nitric oxide dioxygenase activity
FRE64_RS07900	COG0537	adenosine 5'-monophosphoramidase activity
FRE64_RS07910	COG1619	proteins homologs of microcin C7 resistance protein MccF
FRE64_RS07920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRE64_RS07935	COG0706	membrane insertase activity
FRE64_RS07945	COG0594	ribonuclease P activity
FRE64_RS07950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FRE64_RS07955	COG0443	Heat shock 70 kDa protein
FRE64_RS07960	COG0745	RESPONSE REGULATOR receiver
FRE64_RS07965	COG0628	permease
FRE64_RS07980	COG3064	Membrane
FRE64_RS07980	COG4991	sh3 domain protein
FRE64_RS07980	COG0515	serine threonine protein kinase
FRE64_RS08000	COG1674	ftsk spoiiie
FRE64_RS08015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRE64_RS08020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRE64_RS08025	COG0730	response to heat
FRE64_RS08035	COG0366	Alpha amylase catalytic
FRE64_RS08085	COG1122	ATPase activity
FRE64_RS08130	COG1640	4-alpha-glucanotransferase
FRE64_RS08145	COG0415	Belongs to the DNA photolyase family
FRE64_RS08150	COG3659	wide pore channel activity
FRE64_RS08155	COG0702	epimerase
FRE64_RS08160	COG0646	methionine synthase
FRE64_RS08160	COG1410	methionine synthase
FRE64_RS08170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FRE64_RS08175	COG1836	PFAM Integral membrane protein DUF92
FRE64_RS08190	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FRE64_RS08205	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FRE64_RS08220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FRE64_RS08225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FRE64_RS08280	COG1530	ribonuclease E activity
FRE64_RS08285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FRE64_RS08290	COG0542	response to heat
FRE64_RS08310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FRE64_RS08315	COG1496	oxidoreductase activity
FRE64_RS08330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FRE64_RS08335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRE64_RS08380	COG4999	Histidine kinase
FRE64_RS08380	COG3850	Histidine kinase
FRE64_RS08380	COG3437	response regulator, receiver
FRE64_RS08380	COG2205	protein histidine kinase activity
FRE64_RS08390	COG4251	negative regulation of phosphorylation
FRE64_RS08395	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
FRE64_RS08400	COG0632	four-way junction helicase activity
FRE64_RS08405	COG4636	protein conserved in cyanobacteria
FRE64_RS08420	COG0488	(ABC) transporter
FRE64_RS08425	COG0149	triose-phosphate isomerase activity
FRE64_RS08455	COG1121	(ABC) transporter
FRE64_RS08460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRE64_RS08465	COG4095	Psort location CytoplasmicMembrane, score
FRE64_RS08500	COG0312	modulator of DNA gyrase
FRE64_RS08510	COG2239	Acts as a magnesium transporter
FRE64_RS08530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FRE64_RS08535	COG3536	Protein conserved in bacteria
FRE64_RS08540	COG1413	lyase activity
FRE64_RS08545	COG0436	Aminotransferase
FRE64_RS08570	COG5002	protein histidine kinase activity
FRE64_RS08575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FRE64_RS08585	COG0523	cobalamin synthesis protein
FRE64_RS08590	COG0784	Response regulator, receiver
FRE64_RS08590	COG2205	protein histidine kinase activity
FRE64_RS08605	COG0302	gtp cyclohydrolase
FRE64_RS08615	COG0383	alpha-mannosidase activity
FRE64_RS08665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FRE64_RS08670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FRE64_RS08675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FRE64_RS08675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FRE64_RS08695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRE64_RS08700	COG4279	zinc finger
FRE64_RS08725	COG0511	ligase activity, forming carbon-carbon bonds
FRE64_RS08730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FRE64_RS08735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRE64_RS08745	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
FRE64_RS08770	COG1285	pathogenesis
FRE64_RS08775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRE64_RS08795	COG0356	it plays a direct role in the translocation of protons across the membrane
FRE64_RS08805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRE64_RS08815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRE64_RS08825	COG1490	D-aminoacyl-tRNA deacylase activity
FRE64_RS08855	COG0129	dihydroxy-acid dehydratase activity
FRE64_RS08865	COG0517	IMP dehydrogenase activity
FRE64_RS08865	COG1994	Peptidase M50
FRE64_RS08870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FRE64_RS08870	COG1754	DNA topoisomerase type I activity
FRE64_RS08875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FRE64_RS08885	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
FRE64_RS08900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FRE64_RS08910	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
FRE64_RS08925	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRE64_RS08930	COG0527	aspartate kinase activity
FRE64_RS08940	COG0251	oxidation-reduction process
FRE64_RS08950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRE64_RS08960	COG0443	Heat shock 70 kDa protein
FRE64_RS08965	COG0419	ATPase involved in DNA repair
FRE64_RS08970	COG3842	ATPase activity
FRE64_RS08980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRE64_RS08995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRE64_RS09020	COG0410	ABC transporter
FRE64_RS09040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FRE64_RS09040	COG0237	dephospho-CoA kinase activity
FRE64_RS09055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FRE64_RS09065	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
FRE64_RS09070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRE64_RS09075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FRE64_RS09085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRE64_RS09090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FRE64_RS09090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FRE64_RS09100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FRE64_RS09115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FRE64_RS09120	COG3937	granule-associated protein
FRE64_RS09135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FRE64_RS09155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FRE64_RS09170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRE64_RS09175	COG2226	methyltransferase
FRE64_RS09185	COG2094	Belongs to the DNA glycosylase MPG family
FRE64_RS09210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FRE64_RS09215	COG0088	Forms part of the polypeptide exit tunnel
FRE64_RS09220	COG0089	rRNA binding
FRE64_RS09225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FRE64_RS09230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FRE64_RS09235	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FRE64_RS09240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FRE64_RS09245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FRE64_RS09250	COG0255	Belongs to the universal ribosomal protein uL29 family
FRE64_RS09255	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FRE64_RS09260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FRE64_RS09265	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRE64_RS09270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FRE64_RS09275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FRE64_RS09280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRE64_RS09285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRE64_RS09290	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FRE64_RS09295	COG0200	Binds to the 23S rRNA
FRE64_RS09300	COG0201	protein transport
FRE64_RS09305	COG0563	adenylate kinase activity
FRE64_RS09310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FRE64_RS09315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FRE64_RS09320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRE64_RS09325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FRE64_RS09330	COG0202	RNA polymerase activity
FRE64_RS09335	COG0203	ribosomal protein L17
FRE64_RS09340	COG0101	tRNA pseudouridine synthase activity
FRE64_RS09345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FRE64_RS09350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FRE64_RS09355	COG0254	rRNA binding
FRE64_RS09360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FRE64_RS09365	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRE64_RS09375	COG0308	aminopeptidase N
FRE64_RS09390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FRE64_RS09390	COG0140	phosphoribosyl-ATP diphosphatase activity
FRE64_RS09395	COG2197	response regulator
FRE64_RS09415	COG0644	oxidoreductase
FRE64_RS09420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRE64_RS09435	COG0484	heat shock protein binding
FRE64_RS09445	COG1162	GTPase activity
FRE64_RS09455	COG4948	Mandelate Racemase Muconate Lactonizing
FRE64_RS09460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRE64_RS09515	COG1555	photosystem II stabilization
FRE64_RS09520	COG0450	alkyl hydroperoxide reductase
FRE64_RS09525	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FRE64_RS09545	COG0514	ATP-dependent DNA helicase (RecQ)
FRE64_RS09555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FRE64_RS09560	COG4249	Peptidase C14 caspase catalytic subunit p20
FRE64_RS09560	COG2319	Wd-40 repeat
FRE64_RS09600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRE64_RS09605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRE64_RS09610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FRE64_RS09615	COG2059	Chromate
FRE64_RS09630	COG1122	ATPase activity
FRE64_RS09635	COG0024	Methionine aminopeptidase
FRE64_RS09640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FRE64_RS09645	COG3549	Plasmid maintenance system killer
FRE64_RS09655	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FRE64_RS09660	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FRE64_RS09715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FRE64_RS09730	COG0148	phosphopyruvate hydratase activity
FRE64_RS09740	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FRE64_RS09745	COG1606	tRNA processing
FRE64_RS09755	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FRE64_RS09780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FRE64_RS09785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRE64_RS09790	COG0824	Thioesterase
FRE64_RS09810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FRE64_RS09820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRE64_RS09845	COG0735	belongs to the Fur family
FRE64_RS09850	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRE64_RS09855	COG0047	phosphoribosylformylglycinamidine synthase activity
FRE64_RS09860	COG4106	trans-aconitate 2-methyltransferase activity
FRE64_RS09865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FRE64_RS09885	COG2336	PFAM SpoVT AbrB
FRE64_RS09890	COG0459	protein refolding
FRE64_RS09895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FRE64_RS09900	COG3411	Ferredoxin
FRE64_RS09905	COG0745	RESPONSE REGULATOR receiver
FRE64_RS09920	COG0667	Aldo Keto reductase
FRE64_RS09935	COG0625	glutathione transferase activity
FRE64_RS09940	COG2003	Belongs to the UPF0758 family
FRE64_RS09950	COG5398	heme oxygenase
FRE64_RS09960	COG0740	serine-type endopeptidase activity
FRE64_RS09965	COG0740	serine-type endopeptidase activity
FRE64_RS09980	COG1178	ABC-type Fe3 transport system permease component
FRE64_RS09985	COG1982	Orn Lys Arg decarboxylase major
FRE64_RS09990	COG0501	Belongs to the peptidase M48B family
FRE64_RS10025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRE64_RS10030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRE64_RS10035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRE64_RS10040	COG0443	Heat shock 70 kDa protein
FRE64_RS10060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRE64_RS10075	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRE64_RS10090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FRE64_RS10090	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FRE64_RS10095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FRE64_RS10095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FRE64_RS10115	COG2340	Cysteine-rich secretory protein family
FRE64_RS10120	COG0439	Biotin carboxylase
FRE64_RS10140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FRE64_RS10170	COG1666	GTP binding
FRE64_RS10175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FRE64_RS10180	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FRE64_RS10195	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS10200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRE64_RS10205	COG0583	DNA-binding transcription factor activity
FRE64_RS10220	COG3118	belongs to the thioredoxin family
FRE64_RS10225	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FRE64_RS10235	COG1695	Transcriptional regulator
FRE64_RS10250	COG0668	transmembrane transport
FRE64_RS10260	COG2337	Toxic component of a toxin-antitoxin (TA) module
FRE64_RS10265	COG2226	methyltransferase
FRE64_RS10275	COG0165	Argininosuccinate lyase
FRE64_RS10280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FRE64_RS10285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRE64_RS10300	COG3153	acetyltransferase
FRE64_RS10305	COG0408	coproporphyrinogen oxidase activity
FRE64_RS10320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FRE64_RS10330	COG0133	tryptophan synthase activity
FRE64_RS10345	COG0356	it plays a direct role in the translocation of protons across the membrane
FRE64_RS10350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRE64_RS10355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRE64_RS10360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRE64_RS10365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRE64_RS10370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FRE64_RS10375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRE64_RS10390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS10395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRE64_RS10410	COG0681	Belongs to the peptidase S26 family
FRE64_RS10420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FRE64_RS10425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRE64_RS10435	COG4956	integral membrane protein (PIN domain superfamily)
FRE64_RS10460	COG3335	DDE superfamily endonuclease
FRE64_RS10465	COG0454	-acetyltransferase
FRE64_RS10475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FRE64_RS10475	COG0662	Cupin 2, conserved barrel domain protein
FRE64_RS10480	COG0131	Imidazoleglycerol-phosphate dehydratase
FRE64_RS10485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FRE64_RS10490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FRE64_RS10495	COG0321	lipoyl(octanoyl) transferase activity
FRE64_RS10500	COG0596	Alpha beta hydrolase
FRE64_RS10510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FRE64_RS10515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FRE64_RS10520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRE64_RS10525	COG1546	Belongs to the CinA family
FRE64_RS10525	COG1058	Belongs to the CinA family
FRE64_RS10535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRE64_RS10540	COG0628	permease
FRE64_RS10560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FRE64_RS10565	COG1413	lyase activity
FRE64_RS10575	COG1271	oxidase subunit
FRE64_RS10590	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FRE64_RS10595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRE64_RS10600	COG1253	flavin adenine dinucleotide binding
FRE64_RS10605	COG0598	Magnesium transport protein CorA
FRE64_RS10610	COG0584	glycerophosphoryl diester phosphodiesterase
FRE64_RS10625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRE64_RS10645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRE64_RS10655	COG1543	Belongs to the glycosyl hydrolase 57 family
FRE64_RS10665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FRE64_RS10670	COG0515	serine threonine protein kinase
FRE64_RS10670	COG2815	serine threonine protein kinase
FRE64_RS10690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRE64_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
FRE64_RS10705	COG0300	oxidoreductase activity
FRE64_RS10710	COG2072	flavoprotein involved in K transport
FRE64_RS10715	COG4251	negative regulation of phosphorylation
FRE64_RS10730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRE64_RS10750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRE64_RS10760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRE64_RS10765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FRE64_RS10770	COG0268	Binds directly to 16S ribosomal RNA
FRE64_RS10775	COG0084	hydrolase, TatD family'
FRE64_RS10780	COG0085	RNA polymerase activity
FRE64_RS10785	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRE64_RS10790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FRE64_RS10795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRE64_RS10795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRE64_RS10800	COG4221	oxidoreductase activity
FRE64_RS10805	COG0009	L-threonylcarbamoyladenylate synthase
FRE64_RS10810	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FRE64_RS10825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRE64_RS10860	COG1598	PFAM Uncharacterised protein family UPF0150
FRE64_RS10905	COG3344	reverse transcriptase
FRE64_RS10920	COG0617	tRNA 3'-terminal CCA addition
FRE64_RS10925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRE64_RS10925	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FRE64_RS10930	COG1132	(ABC) transporter
FRE64_RS10935	COG1357	PFAM Pentapeptide repeats (8 copies)
FRE64_RS10935	COG0515	serine threonine protein kinase
FRE64_RS10940	COG1040	competence protein
FRE64_RS10945	COG0228	four-way junction DNA binding
FRE64_RS10950	COG1837	Belongs to the UPF0109 family
FRE64_RS10955	COG1702	phosphate starvation-inducible protein PhoH
FRE64_RS10960	COG0314	molybdopterin synthase activity
FRE64_RS10965	COG3842	ATPase activity
FRE64_RS10970	COG1028	Short-chain dehydrogenase reductase Sdr
FRE64_RS11000	COG0724	RNA recognition motif
FRE64_RS11010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FRE64_RS11030	COG1494	fructose-1,6-bisphosphatase
FRE64_RS11035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FRE64_RS11065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FRE64_RS11070	COG0539	negative regulation of cytoplasmic translation
FRE64_RS11110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRE64_RS11120	COG0628	permease
FRE64_RS11125	COG0189	ligase activity
FRE64_RS11130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FRE64_RS11135	COG0768	penicillin binding
FRE64_RS11140	COG2133	pyrroloquinoline quinone binding
FRE64_RS11150	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FRE64_RS11160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRE64_RS11165	COG0581	inorganic phosphate transmembrane transporter activity
FRE64_RS11175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRE64_RS11190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FRE64_RS11200	COG4372	Transposase
FRE64_RS11205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRE64_RS11210	COG0745	RESPONSE REGULATOR receiver
FRE64_RS11215	COG1402	creatininase
FRE64_RS11230	COG1595	DNA-templated transcription, initiation
FRE64_RS11240	COG0824	Thioesterase
FRE64_RS11245	COG0297	glycogen (starch) synthase activity
FRE64_RS11270	COG0435	Glutathione S-transferase
FRE64_RS11285	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FRE64_RS11290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FRE64_RS11310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRE64_RS11330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRE64_RS11350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRE64_RS11360	COG0745	RESPONSE REGULATOR receiver
FRE64_RS11365	COG0739	heme binding
FRE64_RS11395	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FRE64_RS11395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FRE64_RS11400	COG0434	BtpA family
FRE64_RS11410	COG0783	Belongs to the Dps family
FRE64_RS11425	COG1160	GTP binding
FRE64_RS11430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRE64_RS11440	COG3266	domain, Protein
FRE64_RS11440	COG0515	serine threonine protein kinase
FRE64_RS11460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRE64_RS11475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRE64_RS11480	COG1357	PFAM Pentapeptide repeats (8 copies)
FRE64_RS11485	COG0151	Belongs to the GarS family
FRE64_RS11495	COG0077	Prephenate dehydratase
FRE64_RS11500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FRE64_RS11510	COG0557	exoribonuclease II activity
FRE64_RS11515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FRE64_RS11520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FRE64_RS11530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRE64_RS11580	COG0432	Pfam Uncharacterised protein family UPF0047
FRE64_RS11585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRE64_RS11590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS11595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS11600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS11610	COG1420	regulation of RNA biosynthetic process
FRE64_RS11620	COG0400	carboxylic ester hydrolase activity
FRE64_RS11630	COG0316	Belongs to the HesB IscA family
FRE64_RS11635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRE64_RS11640	COG0049	tRNA binding
FRE64_RS11645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FRE64_RS11650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRE64_RS11655	COG0051	transcription antitermination factor activity, RNA binding
FRE64_RS11660	COG1012	belongs to the aldehyde dehydrogenase family
FRE64_RS11665	COG4999	Histidine kinase
FRE64_RS11665	COG3850	Histidine kinase
FRE64_RS11665	COG2205	protein histidine kinase activity
FRE64_RS11665	COG3437	response regulator, receiver
FRE64_RS11675	COG1872	DUF167
FRE64_RS11690	COG0095	Lipoate-protein ligase
FRE64_RS11695	COG2197	response regulator
FRE64_RS11700	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
FRE64_RS11715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRE64_RS11730	COG0436	Aminotransferase
FRE64_RS11735	COG0438	transferase activity, transferring glycosyl groups
FRE64_RS11740	COG0667	Aldo Keto reductase
FRE64_RS11745	COG2124	cytochrome p450
FRE64_RS11750	COG3335	DDE superfamily endonuclease
FRE64_RS11775	COG2124	cytochrome p450
FRE64_RS11780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FRE64_RS11815	COG0116	Belongs to the methyltransferase superfamily
FRE64_RS11825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FRE64_RS11840	COG0745	RESPONSE REGULATOR receiver
FRE64_RS11915	COG1196	nuclear chromosome segregation
FRE64_RS11950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FRE64_RS11955	COG0668	transmembrane transport
FRE64_RS11965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRE64_RS11975	COG4783	chaperone-mediated protein folding
FRE64_RS12005	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FRE64_RS12010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRE64_RS12020	COG0123	including yeast histone deacetylase and acetoin utilization protein
FRE64_RS12035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FRE64_RS12080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRE64_RS12085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FRE64_RS12090	COG0512	Glutamine amidotransferase of anthranilate synthase
FRE64_RS12090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRE64_RS12095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FRE64_RS12100	COG0006	proline dipeptidase activity
FRE64_RS12105	COG0561	phosphatase activity
FRE64_RS12120	COG0156	8-amino-7-oxononanoate synthase activity
FRE64_RS12135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FRE64_RS12150	COG1799	cell septum assembly
FRE64_RS12155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FRE64_RS12160	COG0450	alkyl hydroperoxide reductase
FRE64_RS12165	COG0539	negative regulation of cytoplasmic translation
FRE64_RS12170	COG0412	Dienelactone hydrolase
FRE64_RS12175	COG1136	(ABC) transporter
FRE64_RS12185	COG0574	Belongs to the PEP-utilizing enzyme family
FRE64_RS12185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRE64_RS12190	COG0469	pyruvate kinase activity
FRE64_RS12210	COG1472	Belongs to the glycosyl hydrolase 3 family
FRE64_RS12215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FRE64_RS12220	COG0489	protein tyrosine kinase activity
FRE64_RS12225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FRE64_RS12235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRE64_RS12235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRE64_RS12245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FRE64_RS12260	COG0739	heme binding
FRE64_RS12270	COG0571	ribonuclease III activity
FRE64_RS12285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FRE64_RS12300	COG2385	sporulation resulting in formation of a cellular spore
FRE64_RS12305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRE64_RS12310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRE64_RS12315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRE64_RS12325	COG5002	protein histidine kinase activity
FRE64_RS12330	COG2154	pterin-4-alpha-carbinolamine dehydratase
FRE64_RS12340	COG0070	glutamate synthase
FRE64_RS12340	COG0069	glutamate synthase activity
FRE64_RS12340	COG0067	glutamate synthase
FRE64_RS12345	COG0163	prenyltransferase activity
FRE64_RS12380	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FRE64_RS12385	COG3977	Valine--pyruvate aminotransferase
FRE64_RS12390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FRE64_RS12435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FRE64_RS12445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FRE64_RS12460	COG1587	Uroporphyrinogen-III synthase
FRE64_RS12470	COG0237	dephospho-CoA kinase activity
FRE64_RS12475	COG0180	Tryptophanyl-tRNA synthetase
FRE64_RS12495	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FRE64_RS12510	COG5002	protein histidine kinase activity
FRE64_RS12530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FRE64_RS12550	COG1132	(ABC) transporter
FRE64_RS12560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FRE64_RS12570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRE64_RS12570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRE64_RS12575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRE64_RS12635	COG1132	(ABC) transporter
FRE64_RS12660	COG1132	(ABC) transporter
FRE64_RS12690	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FRE64_RS12695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRE64_RS12935	COG0693	protein deglycase activity
FRE64_RS12940	COG0519	Catalyzes the synthesis of GMP from XMP
FRE64_RS12940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRE64_RS12945	COG0612	Peptidase, M16
FRE64_RS12950	COG0612	Peptidase, M16
FRE64_RS12955	COG1309	transcriptional regulator
FRE64_RS12980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FRE64_RS12985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FRE64_RS13005	COG3118	belongs to the thioredoxin family
FRE64_RS13010	COG1006	Multisubunit Na H antiporter MnhC subunit
FRE64_RS13015	COG0651	ATP synthesis coupled electron transport
FRE64_RS13050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FRE64_RS13095	COG0459	protein refolding
FRE64_RS13100	COG0745	RESPONSE REGULATOR receiver
FRE64_RS13105	COG1489	DNA binding
FRE64_RS13155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRE64_RS13175	COG0312	modulator of DNA gyrase
FRE64_RS13195	COG5001	Diguanylate cyclase
FRE64_RS13205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FRE64_RS13210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FRE64_RS13220	COG3258	Cytochrome c
FRE64_RS13225	COG0489	protein tyrosine kinase activity
FRE64_RS13230	COG0772	Belongs to the SEDS family
FRE64_RS13235	COG0484	heat shock protein binding
FRE64_RS13260	COG2226	methyltransferase
FRE64_RS13265	COG0174	glutamine synthetase
FRE64_RS13305	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FRE64_RS13315	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FRE64_RS13320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRE64_RS13330	COG1459	type II secretion system
FRE64_RS13350	COG0175	sulfate reduction
FRE64_RS13360	COG2885	chlorophyll binding
FRE64_RS13365	COG2885	chlorophyll binding
FRE64_RS13380	COG1309	transcriptional regulator
FRE64_RS13390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FRE64_RS13400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FRE64_RS13415	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRE64_RS13425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FRE64_RS13430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRE64_RS13435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FRE64_RS13450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FRE64_RS13455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRE64_RS13460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FRE64_RS13465	COG3409	Peptidoglycan-binding domain 1 protein
FRE64_RS13465	COG3429	Glucose-6-phosphate dehydrogenase subunit
FRE64_RS13470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRE64_RS13475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FRE64_RS13490	COG0003	Pfam Anion-transporting ATPase
FRE64_RS13495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FRE64_RS13500	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FRE64_RS13530	COG4245	von Willebrand factor, type A
FRE64_RS13550	COG0126	phosphoglycerate kinase activity
FRE64_RS13555	COG0675	Transposase, IS605 OrfB family
FRE64_RS13565	COG3854	ATPases associated with a variety of cellular activities
FRE64_RS13580	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FRE64_RS13585	COG1492	cobalamin metabolic process
FRE64_RS13610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRE64_RS13620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRE64_RS13635	COG0123	including yeast histone deacetylase and acetoin utilization protein
FRE64_RS13640	COG1968	undecaprenyl-diphosphatase activity
FRE64_RS13665	COG2119	membrane
FRE64_RS13675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FRE64_RS13680	COG3631	Ketosteroid isomerase-related protein
FRE64_RS13695	COG1007	ATP synthesis coupled electron transport
FRE64_RS13710	COG1126	abc transporter atp-binding protein
FRE64_RS13715	COG1131	(ABC) transporter
FRE64_RS13730	COG3688	RNA-binding protein containing a PIN domain
FRE64_RS13735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FRE64_RS13745	COG0210	DNA helicase
FRE64_RS13745	COG0210	DNA helicase
FRE64_RS13770	COG2205	protein histidine kinase activity
FRE64_RS13805	COG0384	phenazine biosynthesis protein PhzF
FRE64_RS13810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FRE64_RS13815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FRE64_RS13820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRE64_RS13825	COG0424	maF-like protein
FRE64_RS13840	COG0552	protein localization to endoplasmic reticulum
FRE64_RS13845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FRE64_RS13855	COG0315	cyclic pyranopterin monophosphate synthase activity
FRE64_RS13880	COG1487	ribonuclease activity
FRE64_RS13890	COG4178	(ABC) transporter
FRE64_RS13910	COG1528	Iron-storage protein
FRE64_RS13915	COG0713	ATP synthesis coupled electron transport
FRE64_RS13925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS13930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FRE64_RS13935	COG0372	Belongs to the citrate synthase family
FRE64_RS13940	COG0575	Belongs to the CDS family
FRE64_RS13950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRE64_RS13970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRE64_RS13975	COG1959	2 iron, 2 sulfur cluster binding
FRE64_RS13980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FRE64_RS13985	COG2814	Major facilitator Superfamily
FRE64_RS13990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRE64_RS14005	COG0641	radical SAM
FRE64_RS14010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FRE64_RS14030	COG0641	radical SAM
FRE64_RS14035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FRE64_RS14040	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRE64_RS14045	COG2345	Transcriptional regulator
FRE64_RS14070	COG1192	Involved in chromosome partitioning
FRE64_RS14075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FRE64_RS14080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRE64_RS14085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FRE64_RS14090	COG0544	peptidyl-prolyl cis-trans isomerase activity
FRE64_RS14095	COG0740	serine-type endopeptidase activity
FRE64_RS14100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FRE64_RS14105	COG2211	Major facilitator Superfamily
FRE64_RS14120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRE64_RS14120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FRE64_RS14140	COG1842	Phage shock protein A
FRE64_RS14150	COG2203	Gaf domain
FRE64_RS14150	COG4251	negative regulation of phosphorylation
FRE64_RS14150	COG5001	Diguanylate cyclase
FRE64_RS14150	COG3706	GGDEF domain
FRE64_RS14155	COG0802	atpase or kinase
FRE64_RS14170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FRE64_RS14200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRE64_RS14200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FRE64_RS14205	COG0509	glycine decarboxylation via glycine cleavage system
FRE64_RS14210	COG0217	transcriptional regulatory protein
FRE64_RS14215	COG1357	PFAM Pentapeptide repeats (8 copies)
FRE64_RS14215	COG0515	serine threonine protein kinase
FRE64_RS14220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FRE64_RS14230	COG0328	RNA-DNA hybrid ribonuclease activity
FRE64_RS14250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRE64_RS14295	COG0339	signal peptide processing
FRE64_RS14300	COG3659	wide pore channel activity
FRE64_RS14305	COG3659	wide pore channel activity
FRE64_RS14310	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRE64_RS14315	COG0653	protein targeting
FRE64_RS14320	COG1215	transferase activity, transferring glycosyl groups
FRE64_RS14325	COG3000	fatty acid hydroxylase
FRE64_RS14325	COG0300	oxidoreductase activity
FRE64_RS14360	COG0556	nucleotide-excision repair
FRE64_RS14375	COG2337	Toxic component of a toxin-antitoxin (TA) module
FRE64_RS14385	COG3311	Transcriptional regulator
FRE64_RS14390	COG1569	PIN domain
FRE64_RS14415	COG0633	Ferredoxin
FRE64_RS14420	COG2234	aminopeptidase activity
FRE64_RS14425	COG0167	dihydroorotate dehydrogenase activity
FRE64_RS14450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRE64_RS14465	COG1022	Amp-dependent synthetase and ligase
FRE64_RS14500	COG1166	arginine decarboxylase activity
FRE64_RS14505	COG0024	Methionine aminopeptidase
FRE64_RS14535	COG2197	response regulator
FRE64_RS14545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FRE64_RS14555	COG1480	7TM receptor with intracellular HD hydrolase
FRE64_RS14565	COG0668	transmembrane transport
FRE64_RS14585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FRE64_RS14590	COG0083	homoserine kinase activity
FRE64_RS14625	COG0776	regulation of translation
FRE64_RS14630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FRE64_RS14640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FRE64_RS14645	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FRE64_RS14655	COG1136	(ABC) transporter
FRE64_RS14690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRE64_RS14695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRE64_RS14700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FRE64_RS14705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FRE64_RS14710	COG0729	surface antigen
FRE64_RS14715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FRE64_RS14730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FRE64_RS14735	COG0181	hydroxymethylbilane synthase activity
FRE64_RS14740	COG0443	Heat shock 70 kDa protein
FRE64_RS14745	COG0484	heat shock protein binding
FRE64_RS14750	COG0006	proline dipeptidase activity
FRE64_RS14770	COG0438	transferase activity, transferring glycosyl groups
FRE64_RS14795	COG4447	cellulose binding
FRE64_RS14800	COG1773	rubredoxin
FRE64_RS14805	COG0395	ABC-type sugar transport system, permease component
FRE64_RS14810	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
FRE64_RS14815	COG5322	oxidoreductase activity
FRE64_RS14820	COG0825	malonyl-CoA metabolic process
FRE64_RS14835	COG0515	serine threonine protein kinase
FRE64_RS14840	COG0583	DNA-binding transcription factor activity
FRE64_RS14875	COG0484	heat shock protein binding
FRE64_RS14880	COG0483	inositol monophosphate 1-phosphatase activity
FRE64_RS14885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRE64_RS14890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FRE64_RS14915	COG0587	DNA-directed DNA polymerase activity
FRE64_RS14920	COG2226	methyltransferase
FRE64_RS14925	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FRE64_RS14945	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FRE64_RS14950	COG1959	2 iron, 2 sulfur cluster binding
FRE64_RS14965	COG0612	Peptidase, M16
FRE64_RS14970	COG0501	Belongs to the peptidase M48B family
FRE64_RS14980	COG0649	NAD binding
FRE64_RS15030	COG0640	Transcriptional regulator
FRE64_RS15040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRE64_RS15055	COG1511	domain protein
FRE64_RS15055	COG3264	Mechanosensitive ion channel
FRE64_RS15070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRE64_RS15075	COG0860	N-Acetylmuramoyl-L-alanine amidase
FRE64_RS15080	COG0475	glutathione-regulated potassium exporter activity
FRE64_RS15085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRE64_RS15090	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FRE64_RS15095	COG0829	nickel cation binding
FRE64_RS15100	COG0831	urea catabolic process
FRE64_RS15105	COG0832	Belongs to the urease beta subunit family
FRE64_RS15115	COG0640	Transcriptional regulator
FRE64_RS15125	COG0573	inorganic phosphate transmembrane transporter activity
FRE64_RS15130	COG0581	inorganic phosphate transmembrane transporter activity
FRE64_RS15135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRE64_RS15150	COG0515	serine threonine protein kinase
FRE64_RS15155	COG2062	phosphohistidine phosphatase, SixA
FRE64_RS15160	COG0025	NhaP-type Na H and K H
FRE64_RS15185	COG0497	DNA recombination
FRE64_RS15190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FRE64_RS15195	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
FRE64_RS15215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRE64_RS15230	COG1305	Transglutaminase-like
FRE64_RS15240	COG1070	Carbohydrate kinase
FRE64_RS15250	COG0469	pyruvate kinase activity
FRE64_RS15280	COG0860	N-Acetylmuramoyl-L-alanine amidase
FRE64_RS15305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FRE64_RS15315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FRE64_RS15320	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
FRE64_RS15330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FRE64_RS15335	COG0745	RESPONSE REGULATOR receiver
FRE64_RS15340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRE64_RS15355	COG0778	Nitroreductase
FRE64_RS15360	COG2363	Small membrane protein
FRE64_RS15370	COG1160	GTP binding
FRE64_RS15405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FRE64_RS15415	COG0546	phosphoglycolate phosphatase activity
FRE64_RS15430	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRE64_RS15450	COG0857	belongs to the CobB CobQ family
FRE64_RS15455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FRE64_RS15465	COG2211	Major facilitator Superfamily
FRE64_RS15470	COG2203	Gaf domain
FRE64_RS15470	COG0840	transmembrane signaling receptor activity
FRE64_RS15480	COG0784	Response regulator, receiver
FRE64_RS15485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRE64_RS15490	COG0804	urea catabolic process
FRE64_RS15505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRE64_RS15510	COG1028	Short-chain dehydrogenase reductase Sdr
FRE64_RS15520	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FRE64_RS15530	COG0592	DNA-directed DNA polymerase activity
FRE64_RS15545	COG0071	Belongs to the small heat shock protein (HSP20) family
FRE64_RS15555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRE64_RS15560	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FRE64_RS15575	COG5433	transposase activity
FRE64_RS15595	COG5433	transposase activity
FRE64_RS15635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FRE64_RS15655	COG0170	dolichyl monophosphate biosynthetic process
FRE64_RS15665	COG0457	Tetratricopeptide repeat
FRE64_RS15670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRE64_RS15680	COG0505	Belongs to the CarA family
FRE64_RS15690	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FRE64_RS15695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRE64_RS15705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FRE64_RS15710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FRE64_RS15715	COG0569	domain protein
FRE64_RS15720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FRE64_RS15740	COG0673	inositol 2-dehydrogenase activity
FRE64_RS15755	COG0259	pyridoxamine-phosphate oxidase activity
FRE64_RS15765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FRE64_RS15800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRE64_RS15805	COG0443	Heat shock 70 kDa protein
FRE64_RS15820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRE64_RS15920	COG1653	transport
FRE64_RS15925	COG1175	transmembrane transport
FRE64_RS15935	COG3842	ATPase activity
FRE64_RS15955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRE64_RS15960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FRE64_RS16005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FRE64_RS16015	COG2267	carboxylic ester hydrolase activity
FRE64_RS16020	COG0494	nUDIX hydrolase
FRE64_RS16025	COG0668	transmembrane transport
FRE64_RS16030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FRE64_RS16050	COG1505	serine-type exopeptidase activity
FRE64_RS16065	COG2217	Heavy metal translocating P-type atpase
FRE64_RS16070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FRE64_RS16080	COG0792	nuclease activity
FRE64_RS16085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FRE64_RS16095	COG1562	ergosterol biosynthetic process
FRE64_RS16100	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FRE64_RS16100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRE64_RS16105	COG0800	Aldolase
FRE64_RS16145	COG0668	transmembrane transport
FRE64_RS16155	COG0398	Pfam SNARE associated Golgi protein
FRE64_RS16160	COG0673	inositol 2-dehydrogenase activity
FRE64_RS16165	COG2166	iron-sulfur cluster assembly
FRE64_RS16170	COG0668	transmembrane transport
FRE64_RS16175	COG0668	transmembrane transport
FRE64_RS16180	COG0668	transmembrane transport
FRE64_RS16185	COG0668	transmembrane transport
FRE64_RS16240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRE64_RS16300	COG0322	excinuclease ABC activity
FRE64_RS16305	COG2226	methyltransferase
FRE64_RS16310	COG2252	PERMEase
FRE64_RS16330	COG1032	radical SAM domain protein
FRE64_RS16340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRE64_RS16350	COG2099	Precorrin-6x reductase
FRE64_RS16360	COG3239	Fatty acid desaturase
FRE64_RS16365	COG0105	UTP biosynthetic process
FRE64_RS16385	COG0154	amidase activity
FRE64_RS16400	COG1285	pathogenesis
FRE64_RS16405	COG2239	Acts as a magnesium transporter
FRE64_RS16495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRE64_RS16550	COG1192	Involved in chromosome partitioning
FRE64_RS16555	COG1475	DNA binding
FRE64_RS16575	COG1074	ATP-dependent DNA helicase activity
FRE64_RS16610	COG1518	maintenance of DNA repeat elements
FRE64_RS16685	COG0582	viral genome integration into host DNA
FRE64_RS16690	COG0720	synthase
FRE64_RS16760	COG1111	helicase
FRE64_RS16760	COG1205	dead DEAH box helicase
FRE64_RS16785	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FRE64_RS16860	COG4636	protein conserved in cyanobacteria
FRE64_RS16870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FRE64_RS17010	COG0071	Belongs to the small heat shock protein (HSP20) family
FRE64_RS17040	COG0724	RNA recognition motif
FRE64_RS17050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FRE64_RS17150	COG0071	Belongs to the small heat shock protein (HSP20) family
FRE64_RS17275	COG1192	Involved in chromosome partitioning