locus-tag	class	description
DVS28_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DVS28_RS00010	COG0592	DNA-directed DNA polymerase activity
DVS28_RS00015	COG2318	DinB family
DVS28_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DVS28_RS00030	COG0187	DNA topoisomerase II activity
DVS28_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DVS28_RS00080	COG3858	chitin binding
DVS28_RS00085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DVS28_RS00095	COG0512	Glutamine amidotransferase of anthranilate synthase
DVS28_RS00100	COG2815	serine threonine protein kinase
DVS28_RS00100	COG0515	serine threonine protein kinase
DVS28_RS00105	COG0768	penicillin binding
DVS28_RS00165	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DVS28_RS00170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DVS28_RS00180	COG1131	(ABC) transporter
DVS28_RS00210	COG1597	lipid kinase activity
DVS28_RS00220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DVS28_RS00230	COG0405	Gamma-glutamyltransferase
DVS28_RS00235	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS00250	COG1063	alcohol dehydrogenase
DVS28_RS00265	COG2920	part of a sulfur-relay system
DVS28_RS00280	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DVS28_RS00285	COG2188	Transcriptional regulator
DVS28_RS00290	COG1063	alcohol dehydrogenase
DVS28_RS00305	COG0437	4 iron, 4 sulfur cluster binding
DVS28_RS00310	COG0243	molybdopterin cofactor binding
DVS28_RS00325	COG0425	Belongs to the sulfur carrier protein TusA family
DVS28_RS00330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DVS28_RS00330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DVS28_RS00350	COG1404	Belongs to the peptidase S8 family
DVS28_RS00375	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS00385	COG1024	Enoyl-CoA hydratase
DVS28_RS00390	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS00400	COG0251	oxidation-reduction process
DVS28_RS00405	COG3360	Dodecin
DVS28_RS00410	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DVS28_RS00425	COG1742	UPF0060 membrane protein
DVS28_RS00440	COG0516	GMP reductase activity
DVS28_RS00440	COG0517	IMP dehydrogenase activity
DVS28_RS00445	COG3706	GGDEF domain
DVS28_RS00505	COG1216	Glycosyl transferase, family 2
DVS28_RS00530	COG3706	GGDEF domain
DVS28_RS00550	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS00570	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS00575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DVS28_RS00595	COG2247	cell wall binding repeat
DVS28_RS00595	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS00615	COG0302	gtp cyclohydrolase
DVS28_RS00635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DVS28_RS00645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DVS28_RS00685	COG0723	plastoquinol--plastocyanin reductase activity
DVS28_RS00690	COG0659	secondary active sulfate transmembrane transporter activity
DVS28_RS00695	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS00695	COG2247	cell wall binding repeat
DVS28_RS00705	COG0411	ABC transporter
DVS28_RS00725	COG1309	transcriptional regulator
DVS28_RS00730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DVS28_RS00735	COG2205	protein histidine kinase activity
DVS28_RS00740	COG5001	Diguanylate cyclase
DVS28_RS00740	COG3300	MHYT domain
DVS28_RS00750	COG1793	dna ligase
DVS28_RS00755	COG0514	ATP-dependent DNA helicase (RecQ)
DVS28_RS00775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DVS28_RS00785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DVS28_RS00800	COG2199	diguanylate cyclase activity
DVS28_RS00805	COG1295	ribonuclease BN
DVS28_RS00835	COG0697	spore germination
DVS28_RS00855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DVS28_RS00885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DVS28_RS00900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DVS28_RS00940	COG3938	Belongs to the proline racemase family
DVS28_RS00970	COG1129	ABC transporter
DVS28_RS00975	COG1172	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS00980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DVS28_RS00990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DVS28_RS01000	COG0697	spore germination
DVS28_RS01025	COG3592	Divergent 4Fe-4S mono-cluster
DVS28_RS01030	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS01050	COG1393	Belongs to the ArsC family
DVS28_RS01065	COG2226	methyltransferase
DVS28_RS01080	COG5001	Diguanylate cyclase
DVS28_RS01090	COG3848	Pyruvate phosphate dikinase
DVS28_RS01090	COG0574	Belongs to the PEP-utilizing enzyme family
DVS28_RS01130	COG0667	Aldo Keto reductase
DVS28_RS01170	COG2205	protein histidine kinase activity
DVS28_RS01220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DVS28_RS01220	COG4651	solute:proton antiporter activity
DVS28_RS01225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DVS28_RS01230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DVS28_RS01230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DVS28_RS01235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DVS28_RS01280	COG1201	RNA secondary structure unwinding
DVS28_RS01330	COG3328	transposase activity
DVS28_RS01355	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
DVS28_RS01365	COG4245	von Willebrand factor, type A
DVS28_RS01370	COG0419	ATPase involved in DNA repair
DVS28_RS01375	COG0420	3'-5' exonuclease activity
DVS28_RS01420	COG4221	oxidoreductase activity
DVS28_RS01475	COG2072	flavoprotein involved in K transport
DVS28_RS01485	COG1725	Transcriptional regulator
DVS28_RS01495	COG1131	(ABC) transporter
DVS28_RS01505	COG3706	GGDEF domain
DVS28_RS01535	COG0280	phosphate acetyltransferase
DVS28_RS01535	COG0857	belongs to the CobB CobQ family
DVS28_RS01540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DVS28_RS01555	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS01630	COG0456	acetyltransferase
DVS28_RS01640	COG0514	ATP-dependent DNA helicase (RecQ)
DVS28_RS01710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DVS28_RS01715	COG0602	queuosine metabolic process
DVS28_RS01720	COG1469	GTP cyclohydrolase I activity
DVS28_RS01730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DVS28_RS01735	COG1074	ATP-dependent DNA helicase activity
DVS28_RS01860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DVS28_RS01905	COG1595	DNA-templated transcription, initiation
DVS28_RS01950	COG0456	acetyltransferase
DVS28_RS02015	COG0513	Belongs to the DEAD box helicase family
DVS28_RS02055	COG0583	DNA-binding transcription factor activity
DVS28_RS02060	COG3022	response to hydroperoxide
DVS28_RS02100	COG3300	MHYT domain
DVS28_RS02100	COG5001	Diguanylate cyclase
DVS28_RS02140	COG0419	ATPase involved in DNA repair
DVS28_RS02150	COG0210	DNA helicase
DVS28_RS02155	COG1983	PspC domain protein
DVS28_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS02165	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS02165	COG2247	cell wall binding repeat
DVS28_RS02205	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS02210	COG1132	(ABC) transporter
DVS28_RS02250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DVS28_RS02275	COG4607	ABC-type enterochelin transport system periplasmic component
DVS28_RS02280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DVS28_RS02285	COG4605	iron ion homeostasis
DVS28_RS02290	COG4604	ABC transporter, ATP-binding protein
DVS28_RS02310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DVS28_RS02375	COG1595	DNA-templated transcription, initiation
DVS28_RS02405	COG5001	Diguanylate cyclase
DVS28_RS02420	COG2815	serine threonine protein kinase
DVS28_RS02420	COG0515	serine threonine protein kinase
DVS28_RS02430	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS02435	COG2301	Belongs to the HpcH HpaI aldolase family
DVS28_RS02440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DVS28_RS02445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DVS28_RS02460	COG2205	protein histidine kinase activity
DVS28_RS02500	COG0475	glutathione-regulated potassium exporter activity
DVS28_RS02525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DVS28_RS02555	COG3263	regulation of cellular component size
DVS28_RS02565	COG0077	Prephenate dehydratase
DVS28_RS02575	COG0668	transmembrane transport
DVS28_RS02585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DVS28_RS02595	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS02605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DVS28_RS02645	COG2301	Belongs to the HpcH HpaI aldolase family
DVS28_RS02725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DVS28_RS02740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DVS28_RS02750	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DVS28_RS02760	COG0022	dehydrogenase e1 component
DVS28_RS02765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DVS28_RS02770	COG3199	ATP-NAD kinase
DVS28_RS02795	COG0840	transmembrane signaling receptor activity
DVS28_RS02800	COG2201	protein-glutamate methylesterase activity
DVS28_RS02805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DVS28_RS02815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DVS28_RS02830	COG0596	Alpha beta hydrolase
DVS28_RS02835	COG2267	carboxylic ester hydrolase activity
DVS28_RS02855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DVS28_RS02855	COG2169	Transcriptional regulator
DVS28_RS02865	COG1233	COG1233 Phytoene dehydrogenase and related
DVS28_RS02880	COG0582	viral genome integration into host DNA
DVS28_RS02925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DVS28_RS02930	COG2313	pseudouridylate synthase activity
DVS28_RS02945	COG0071	Belongs to the small heat shock protein (HSP20) family
DVS28_RS02950	COG0590	tRNA wobble adenosine to inosine editing
DVS28_RS02980	COG1278	Cold shock
DVS28_RS02990	COG5001	Diguanylate cyclase
DVS28_RS03015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DVS28_RS03020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DVS28_RS03035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DVS28_RS03040	COG4221	oxidoreductase activity
DVS28_RS03045	COG0789	Transcriptional regulator
DVS28_RS03065	COG2264	protein methyltransferase activity
DVS28_RS03075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DVS28_RS03080	COG0189	ligase activity
DVS28_RS03080	COG0569	domain protein
DVS28_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS03135	COG0183	Belongs to the thiolase family
DVS28_RS03205	COG1070	Carbohydrate kinase
DVS28_RS03210	COG2132	Multicopper oxidase
DVS28_RS03255	COG1408	metallophosphoesterase
DVS28_RS03265	COG2894	cell division
DVS28_RS03305	COG0038	chloride channel
DVS28_RS03350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DVS28_RS03370	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DVS28_RS03375	COG2247	cell wall binding repeat
DVS28_RS03375	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS03380	COG2247	cell wall binding repeat
DVS28_RS03380	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS03415	COG4251	negative regulation of phosphorylation
DVS28_RS03420	COG0784	Response regulator, receiver
DVS28_RS03430	COG0646	methionine synthase
DVS28_RS03430	COG1410	methionine synthase
DVS28_RS03435	COG2197	response regulator
DVS28_RS03450	COG2205	protein histidine kinase activity
DVS28_RS03450	COG0784	Response regulator, receiver
DVS28_RS03460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DVS28_RS03475	COG0745	RESPONSE REGULATOR receiver
DVS28_RS03485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DVS28_RS03490	COG0745	RESPONSE REGULATOR receiver
DVS28_RS03495	COG0835	chemotaxis
DVS28_RS03500	COG0643	Histidine kinase
DVS28_RS03500	COG0784	Response regulator, receiver
DVS28_RS03500	COG2198	Histidine kinase
DVS28_RS03505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DVS28_RS03510	COG0534	Mate efflux family protein
DVS28_RS03515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DVS28_RS03520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DVS28_RS03525	COG2197	response regulator
DVS28_RS03545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DVS28_RS03550	COG3132	Protein of unknown function, DUF480
DVS28_RS03575	COG2027	D-alanyl-D-alanine carboxypeptidase
DVS28_RS03580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DVS28_RS03590	COG2264	protein methyltransferase activity
DVS28_RS03635	COG3191	aminopeptidase activity
DVS28_RS03665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DVS28_RS03685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DVS28_RS03690	COG0459	protein refolding
DVS28_RS03715	COG2208	phosphoserine phosphatase activity
DVS28_RS03715	COG2770	Histidine kinase
DVS28_RS03730	COG0489	protein tyrosine kinase activity
DVS28_RS03735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DVS28_RS03745	COG0579	oxidoreductase
DVS28_RS03755	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DVS28_RS03760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DVS28_RS03770	COG0438	transferase activity, transferring glycosyl groups
DVS28_RS03775	COG0438	transferase activity, transferring glycosyl groups
DVS28_RS03800	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS03800	COG2247	cell wall binding repeat
DVS28_RS03815	COG0297	glycogen (starch) synthase activity
DVS28_RS03820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DVS28_RS03835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DVS28_RS03840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DVS28_RS03845	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DVS28_RS03855	COG0529	Catalyzes the synthesis of activated sulfate
DVS28_RS03860	COG3273	potassium ion transport
DVS28_RS03860	COG0471	metal ion transport
DVS28_RS03875	COG0516	GMP reductase activity
DVS28_RS03930	COG0519	Catalyzes the synthesis of GMP from XMP
DVS28_RS03930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DVS28_RS03955	COG1940	carbohydrate kinase activity
DVS28_RS03960	COG0673	inositol 2-dehydrogenase activity
DVS28_RS03965	COG1129	ABC transporter
DVS28_RS03970	COG4211	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS03990	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS03990	COG2247	cell wall binding repeat
DVS28_RS04000	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DVS28_RS04010	COG0045	succinate-CoA ligase (ADP-forming) activity
DVS28_RS04015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DVS28_RS04045	COG1132	(ABC) transporter
DVS28_RS04050	COG1132	(ABC) transporter
DVS28_RS04085	COG0039	L-malate dehydrogenase activity
DVS28_RS04095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DVS28_RS04100	COG0668	transmembrane transport
DVS28_RS04115	COG0138	bifunctional purine biosynthesis protein purh
DVS28_RS04135	COG0515	serine threonine protein kinase
DVS28_RS04140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DVS28_RS04155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DVS28_RS04160	COG3300	MHYT domain
DVS28_RS04160	COG5001	Diguanylate cyclase
DVS28_RS04165	COG1404	Belongs to the peptidase S8 family
DVS28_RS04175	COG1404	Belongs to the peptidase S8 family
DVS28_RS04185	COG1404	Belongs to the peptidase S8 family
DVS28_RS04190	COG0390	transport system, permease component
DVS28_RS04195	COG0180	Tryptophanyl-tRNA synthetase
DVS28_RS04200	COG0488	(ABC) transporter
DVS28_RS04205	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DVS28_RS04220	COG1053	succinate dehydrogenase
DVS28_RS04225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DVS28_RS04240	COG2018	Roadblock/LC7 domain
DVS28_RS04250	COG3300	MHYT domain
DVS28_RS04250	COG5001	Diguanylate cyclase
DVS28_RS04265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DVS28_RS04265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DVS28_RS04285	COG1595	DNA-templated transcription, initiation
DVS28_RS04300	COG0745	RESPONSE REGULATOR receiver
DVS28_RS04330	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS04335	COG3328	transposase activity
DVS28_RS04355	COG1132	(ABC) transporter
DVS28_RS04360	COG1132	(ABC) transporter
DVS28_RS04365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DVS28_RS04370	COG2247	cell wall binding repeat
DVS28_RS04370	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS04405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DVS28_RS04465	COG0725	ABC transporter, periplasmic molybdate-binding protein
DVS28_RS04485	COG4770	biotin carboxylase activity
DVS28_RS04500	COG3540	Alkaline phosphatase
DVS28_RS04505	COG0596	Alpha beta hydrolase
DVS28_RS04540	COG4335	DNA alkylation repair
DVS28_RS04550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DVS28_RS04560	COG0789	Transcriptional regulator
DVS28_RS04565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DVS28_RS04565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DVS28_RS04580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DVS28_RS04590	COG1024	Enoyl-CoA hydratase
DVS28_RS04610	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS04615	COG3706	GGDEF domain
DVS28_RS04630	COG2340	Cysteine-rich secretory protein family
DVS28_RS04645	COG1162	GTPase activity
DVS28_RS04655	COG1316	TRANSCRIPTIONal
DVS28_RS04665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DVS28_RS04670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DVS28_RS04680	COG1091	dTDP-4-dehydrorhamnose reductase activity
DVS28_RS04690	COG2385	sporulation resulting in formation of a cellular spore
DVS28_RS04690	COG2247	cell wall binding repeat
DVS28_RS04695	COG1215	transferase activity, transferring glycosyl groups
DVS28_RS04715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DVS28_RS04730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DVS28_RS04755	COG0297	glycogen (starch) synthase activity
DVS28_RS04800	COG1215	transferase activity, transferring glycosyl groups
DVS28_RS04815	COG1215	transferase activity, transferring glycosyl groups
DVS28_RS04845	COG0277	FAD linked oxidase domain protein
DVS28_RS04865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DVS28_RS04870	COG2835	tetraacyldisaccharide 4'-kinase activity
DVS28_RS04900	COG0604	alcohol dehydrogenase
DVS28_RS04905	COG0531	amino acid
DVS28_RS04910	COG0569	domain protein
DVS28_RS04925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DVS28_RS04930	COG2197	response regulator
DVS28_RS04940	COG0653	protein targeting
DVS28_RS04945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DVS28_RS04965	COG0494	nUDIX hydrolase
DVS28_RS04980	COG1595	DNA-templated transcription, initiation
DVS28_RS05010	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DVS28_RS05025	COG1597	lipid kinase activity
DVS28_RS05030	COG3547	Transposase (IS116 IS110 IS902 family)
DVS28_RS05035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DVS28_RS05040	COG0205	6-phosphofructokinase activity
DVS28_RS05055	COG2208	phosphoserine phosphatase activity
DVS28_RS05075	COG3300	MHYT domain
DVS28_RS05075	COG5001	Diguanylate cyclase
DVS28_RS05095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DVS28_RS05100	COG0601	transmembrane transport
DVS28_RS05120	COG1802	Transcriptional regulator
DVS28_RS05145	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS05145	COG2247	cell wall binding repeat
DVS28_RS05180	COG1201	RNA secondary structure unwinding
DVS28_RS05185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DVS28_RS05200	COG0545	Peptidyl-prolyl cis-trans isomerase
DVS28_RS05205	COG0367	asparagine synthase
DVS28_RS05235	COG1131	(ABC) transporter
DVS28_RS05255	COG3328	transposase activity
DVS28_RS05260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DVS28_RS05295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DVS28_RS05310	COG1061	Type III restriction enzyme res subunit
DVS28_RS05390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DVS28_RS05415	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS05425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DVS28_RS05430	COG4122	O-methyltransferase activity
DVS28_RS05435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DVS28_RS05440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DVS28_RS05445	COG0671	phosphoesterase, PA-phosphatase related
DVS28_RS05465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DVS28_RS05470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DVS28_RS05505	COG0494	nUDIX hydrolase
DVS28_RS05515	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS05525	COG2226	methyltransferase
DVS28_RS05530	COG0613	PHP domain protein
DVS28_RS05535	COG2197	response regulator
DVS28_RS05545	COG0446	pyridine nucleotide-disulphide oxidoreductase
DVS28_RS05550	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DVS28_RS05570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DVS28_RS05580	COG0515	serine threonine protein kinase
DVS28_RS05580	COG2815	serine threonine protein kinase
DVS28_RS05635	COG1674	ftsk spoiiie
DVS28_RS05665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DVS28_RS05680	COG1338	Plays a role in the flagellum-specific transport system
DVS28_RS05690	COG1776	CheC inhibitor of MCP methylation
DVS28_RS05690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DVS28_RS05695	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DVS28_RS05725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DVS28_RS05735	COG0741	lytic transglycosylase activity
DVS28_RS05745	COG1157	protein secretion by the type III secretion system
DVS28_RS05755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DVS28_RS05765	COG1677	Flagellar hook-basal body complex protein FliE
DVS28_RS05775	COG1815	bacterial-type flagellum-dependent cell motility
DVS28_RS05790	COG1516	flagellar protein fliS
DVS28_RS05805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DVS28_RS05810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DVS28_RS05815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DVS28_RS05825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DVS28_RS05830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DVS28_RS05835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DVS28_RS05845	COG2197	response regulator
DVS28_RS05855	COG1256	bacterial-type flagellum assembly
DVS28_RS05855	COG4786	Flagellar basal body rod
DVS28_RS05865	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DVS28_RS05885	COG0457	Tetratricopeptide repeat
DVS28_RS05885	COG0463	Glycosyl transferase, family 2
DVS28_RS05900	COG0483	inositol monophosphate 1-phosphatase activity
DVS28_RS05905	COG0513	Belongs to the DEAD box helicase family
DVS28_RS05915	COG3654	unkown
DVS28_RS05930	COG1850	ribulose-bisphosphate carboxylase activity
DVS28_RS05955	COG3547	Transposase (IS116 IS110 IS902 family)
DVS28_RS05985	COG1309	transcriptional regulator
DVS28_RS06000	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DVS28_RS06050	COG1162	GTPase activity
DVS28_RS06085	COG2200	EAL domain
DVS28_RS06085	COG2199	diguanylate cyclase activity
DVS28_RS06095	COG1331	Highly conserved protein containing a thioredoxin domain
DVS28_RS06105	COG0270	DNA (cytosine-5-)-methyltransferase activity
DVS28_RS06110	COG0270	DNA (cytosine-5-)-methyltransferase activity
DVS28_RS06120	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS06170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DVS28_RS06205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DVS28_RS06210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DVS28_RS06240	COG0488	(ABC) transporter
DVS28_RS06245	COG2409	Drug exporters of the RND superfamily
DVS28_RS06260	COG0215	cysteine-tRNA ligase activity
DVS28_RS06265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DVS28_RS06285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DVS28_RS06290	COG0745	RESPONSE REGULATOR receiver
DVS28_RS06320	COG0314	molybdopterin synthase activity
DVS28_RS06330	COG1077	Cell shape determining protein MreB Mrl
DVS28_RS06340	COG2045	Belongs to the ComB family
DVS28_RS06345	COG5002	protein histidine kinase activity
DVS28_RS06355	COG3599	regulation of cell shape
DVS28_RS06360	COG1615	UPF0182 protein
DVS28_RS06365	COG2226	methyltransferase
DVS28_RS06390	COG0574	Belongs to the PEP-utilizing enzyme family
DVS28_RS06390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DVS28_RS06400	COG1013	pyruvate-flavodoxin oxidoreductase activity
DVS28_RS06400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DVS28_RS06400	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DVS28_RS06400	COG0674	pyruvate-flavodoxin oxidoreductase activity
DVS28_RS06410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DVS28_RS06410	COG0617	tRNA 3'-terminal CCA addition
DVS28_RS06410	COG0517	IMP dehydrogenase activity
DVS28_RS06425	COG3830	Belongs to the UPF0237 family
DVS28_RS06425	COG0560	Phosphoserine phosphatase
DVS28_RS06440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DVS28_RS06460	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DVS28_RS06475	COG0154	amidase activity
DVS28_RS06480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DVS28_RS06490	COG1946	Acyl-CoA thioesterase
DVS28_RS06505	COG0456	acetyltransferase
DVS28_RS06510	COG0483	inositol monophosphate 1-phosphatase activity
DVS28_RS06560	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DVS28_RS06595	COG3396	Phenylacetate-CoA oxygenase
DVS28_RS06610	COG2151	metal-sulfur cluster biosynthetic enzyme
DVS28_RS06620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DVS28_RS06635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DVS28_RS06645	COG2884	Cell division ATP-binding protein ftsE
DVS28_RS06650	COG2177	Part of the ABC transporter FtsEX involved in
DVS28_RS06655	COG0739	heme binding
DVS28_RS06655	COG1196	nuclear chromosome segregation
DVS28_RS06655	COG0741	lytic transglycosylase activity
DVS28_RS06660	COG0793	Belongs to the peptidase S41A family
DVS28_RS06665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DVS28_RS06685	COG0513	Belongs to the DEAD box helicase family
DVS28_RS06690	COG1988	membrane-bound metal-dependent
DVS28_RS06705	COG5002	protein histidine kinase activity
DVS28_RS06710	COG0709	Synthesizes selenophosphate from selenide and ATP
DVS28_RS06745	COG0183	Belongs to the thiolase family
DVS28_RS06750	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS06755	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS06785	COG1234	tRNA 3'-trailer cleavage
DVS28_RS06790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DVS28_RS06795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DVS28_RS06820	COG2018	Roadblock/LC7 domain
DVS28_RS06845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DVS28_RS06860	COG2723	6-phospho-beta-galactosidase activity
DVS28_RS06885	COG0789	Transcriptional regulator
DVS28_RS06905	COG3706	GGDEF domain
DVS28_RS06925	COG1448	Aminotransferase
DVS28_RS06930	COG1278	Cold shock
DVS28_RS06945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DVS28_RS06955	COG1404	Belongs to the peptidase S8 family
DVS28_RS06965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DVS28_RS06975	COG3483	tryptophan 2,3-dioxygenase activity
DVS28_RS06980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DVS28_RS06990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DVS28_RS07000	COG2860	membrane
DVS28_RS07035	COG1253	flavin adenine dinucleotide binding
DVS28_RS07040	COG3300	MHYT domain
DVS28_RS07040	COG5001	Diguanylate cyclase
DVS28_RS07055	COG0702	epimerase
DVS28_RS07095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DVS28_RS07100	COG3903	Transcriptional regulator
DVS28_RS07100	COG3629	intracellular signal transduction
DVS28_RS07215	COG2135	peptidase activity
DVS28_RS07240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DVS28_RS07260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DVS28_RS07270	COG2072	flavoprotein involved in K transport
DVS28_RS07280	COG2801	Transposase and inactivated derivatives
DVS28_RS07290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DVS28_RS07320	COG0544	peptidyl-prolyl cis-trans isomerase activity
DVS28_RS07330	COG0740	serine-type endopeptidase activity
DVS28_RS07335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DVS28_RS07345	COG2267	carboxylic ester hydrolase activity
DVS28_RS07355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DVS28_RS07365	COG0525	valine-tRNA ligase activity
DVS28_RS07375	COG0285	dihydrofolate synthase activity
DVS28_RS07385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DVS28_RS07390	COG0105	UTP biosynthetic process
DVS28_RS07410	COG3300	MHYT domain
DVS28_RS07410	COG5001	Diguanylate cyclase
DVS28_RS07430	COG2003	Belongs to the UPF0758 family
DVS28_RS07435	COG1077	Cell shape determining protein MreB Mrl
DVS28_RS07440	COG1792	Involved in formation and maintenance of cell shape
DVS28_RS07455	COG0768	penicillin binding
DVS28_RS07460	COG0772	Belongs to the SEDS family
DVS28_RS07470	COG3001	Fructosamine kinase
DVS28_RS07475	COG4948	Mandelate Racemase Muconate Lactonizing
DVS28_RS07485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DVS28_RS07495	COG1765	OsmC-like protein
DVS28_RS07530	COG0183	Belongs to the thiolase family
DVS28_RS07535	COG1250	3-hydroxyacyl-CoA dehydrogenase
DVS28_RS07535	COG1024	Enoyl-CoA hydratase
DVS28_RS07570	COG1530	ribonuclease E activity
DVS28_RS07575	COG2010	Cytochrome c
DVS28_RS07575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DVS28_RS07580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DVS28_RS07615	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS07635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DVS28_RS07640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DVS28_RS07650	COG4552	Acetyltransferase involved in intracellular survival and related
DVS28_RS07675	COG1216	Glycosyl transferase, family 2
DVS28_RS07725	COG2936	dipeptidyl-peptidase activity
DVS28_RS07730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DVS28_RS07735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DVS28_RS07745	COG2508	Transcriptional regulator
DVS28_RS07755	COG2409	Drug exporters of the RND superfamily
DVS28_RS07765	COG0542	response to heat
DVS28_RS07785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DVS28_RS07790	COG1316	TRANSCRIPTIONal
DVS28_RS07795	COG0799	negative regulation of ribosome biogenesis
DVS28_RS07840	COG1596	polysaccharide export
DVS28_RS07840	COG1555	photosystem II stabilization
DVS28_RS07845	COG2333	competence protein COMEC
DVS28_RS07845	COG0658	competence protein
DVS28_RS07900	COG2247	cell wall binding repeat
DVS28_RS07900	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS07910	COG0481	GTPase activity
DVS28_RS07925	COG2199	diguanylate cyclase activity
DVS28_RS07925	COG2200	EAL domain
DVS28_RS07925	COG2203	Gaf domain
DVS28_RS07930	COG3300	MHYT domain
DVS28_RS07930	COG5001	Diguanylate cyclase
DVS28_RS07945	COG1420	regulation of RNA biosynthetic process
DVS28_RS07950	COG0484	heat shock protein binding
DVS28_RS07955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DVS28_RS07960	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS07960	COG2247	cell wall binding repeat
DVS28_RS07965	COG1505	serine-type exopeptidase activity
DVS28_RS08015	COG1937	Protein conserved in bacteria
DVS28_RS08020	COG3383	formate dehydrogenase (NAD+) activity
DVS28_RS08035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DVS28_RS08065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DVS28_RS08075	COG0295	cytidine deaminase activity
DVS28_RS08080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DVS28_RS08100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DVS28_RS08125	COG0183	Belongs to the thiolase family
DVS28_RS08145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DVS28_RS08155	COG3328	transposase activity
DVS28_RS08175	COG1349	DNA-binding transcription factor activity
DVS28_RS08180	COG3345	alpha-galactosidase
DVS28_RS08190	COG1085	galactose-1-phosphate uridylyltransferase
DVS28_RS08200	COG1175	transmembrane transport
DVS28_RS08205	COG0395	ABC-type sugar transport system, permease component
DVS28_RS08220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DVS28_RS08230	COG0438	transferase activity, transferring glycosyl groups
DVS28_RS08240	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DVS28_RS08245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DVS28_RS08280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DVS28_RS08280	COG2213	PTS system mannitol-specific
DVS28_RS08290	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DVS28_RS08295	COG0217	transcriptional regulatory protein
DVS28_RS08300	COG0454	-acetyltransferase
DVS28_RS08315	COG0693	protein deglycase activity
DVS28_RS08320	COG0277	FAD linked oxidase domain protein
DVS28_RS08330	COG0632	four-way junction helicase activity
DVS28_RS08335	COG2255	four-way junction helicase activity
DVS28_RS08340	COG1862	Preprotein translocase
DVS28_RS08350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DVS28_RS08355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DVS28_RS08360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DVS28_RS08365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DVS28_RS08370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DVS28_RS08375	COG0124	histidyl-tRNA synthetase
DVS28_RS08400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DVS28_RS08415	COG0297	glycogen (starch) synthase activity
DVS28_RS08430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DVS28_RS08440	COG3328	transposase activity
DVS28_RS08515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DVS28_RS08525	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DVS28_RS08545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DVS28_RS08550	COG0667	Aldo Keto reductase
DVS28_RS08555	COG2385	sporulation resulting in formation of a cellular spore
DVS28_RS08555	COG2247	cell wall binding repeat
DVS28_RS08560	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS08620	COG1472	Belongs to the glycosyl hydrolase 3 family
DVS28_RS08625	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DVS28_RS08635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DVS28_RS08640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DVS28_RS08645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DVS28_RS08655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DVS28_RS08660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DVS28_RS08670	COG1459	type II secretion system
DVS28_RS08690	COG4968	Prepilin-type N-terminal cleavage methylation domain
DVS28_RS08725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DVS28_RS08730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DVS28_RS08735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DVS28_RS08745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DVS28_RS08750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DVS28_RS08760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DVS28_RS08765	COG0540	Belongs to the ATCase OTCase family
DVS28_RS08770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DVS28_RS08775	COG0505	Belongs to the CarA family
DVS28_RS08780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DVS28_RS08805	COG0167	dihydroorotate dehydrogenase activity
DVS28_RS08810	COG2247	cell wall binding repeat
DVS28_RS08810	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS08825	COG0284	orotidine-5'-phosphate decarboxylase activity
DVS28_RS08830	COG1846	Transcriptional regulator
DVS28_RS08830	COG0456	acetyltransferase
DVS28_RS08835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DVS28_RS08845	COG0194	GDP metabolic process
DVS28_RS08855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DVS28_RS08860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DVS28_RS08865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DVS28_RS08870	COG0242	peptide deformylase activity
DVS28_RS08875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DVS28_RS08890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DVS28_RS08890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DVS28_RS08900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DVS28_RS08900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DVS28_RS08905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DVS28_RS08925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DVS28_RS08935	COG1132	(ABC) transporter
DVS28_RS08950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DVS28_RS08960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DVS28_RS08965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DVS28_RS08970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DVS28_RS08980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DVS28_RS08985	COG0072	phenylalanine-tRNA ligase activity
DVS28_RS08985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DVS28_RS08995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DVS28_RS09005	COG1940	carbohydrate kinase activity
DVS28_RS09025	COG4251	negative regulation of phosphorylation
DVS28_RS09030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DVS28_RS09050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DVS28_RS09055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DVS28_RS09060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DVS28_RS09065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DVS28_RS09070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DVS28_RS09080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DVS28_RS09095	COG0165	Argininosuccinate lyase
DVS28_RS09120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DVS28_RS09120	COG1796	DNA polymerase
DVS28_RS09225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DVS28_RS09250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DVS28_RS09270	COG0504	CTP synthase activity
DVS28_RS09285	COG4974	Belongs to the 'phage' integrase family
DVS28_RS09290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DVS28_RS09305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DVS28_RS09310	COG1187	pseudouridine synthase activity
DVS28_RS09325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DVS28_RS09360	COG3537	Alpha-1,2-mannosidase
DVS28_RS09380	COG2813	Specifically methylates the guanine in position
DVS28_RS09395	COG3012	SEC-C Motif Domain Protein
DVS28_RS09410	COG4608	Belongs to the ABC transporter superfamily
DVS28_RS09415	COG0444	Belongs to the ABC transporter superfamily
DVS28_RS09420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DVS28_RS09425	COG0601	transmembrane transport
DVS28_RS09430	COG0747	negative chemotaxis
DVS28_RS09435	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DVS28_RS09445	COG2733	membrane
DVS28_RS09465	COG0297	glycogen (starch) synthase activity
DVS28_RS09470	COG2814	Major facilitator Superfamily
DVS28_RS09480	COG3942	CHAP domain
DVS28_RS09480	COG1388	LysM domain
DVS28_RS09485	COG3300	MHYT domain
DVS28_RS09485	COG5001	Diguanylate cyclase
DVS28_RS09495	COG4251	negative regulation of phosphorylation
DVS28_RS09495	COG3706	GGDEF domain
DVS28_RS09495	COG2203	Gaf domain
DVS28_RS09495	COG5001	Diguanylate cyclase
DVS28_RS09500	COG2723	6-phospho-beta-galactosidase activity
DVS28_RS09505	COG0395	ABC-type sugar transport system, permease component
DVS28_RS09510	COG1175	transmembrane transport
DVS28_RS09535	COG0395	ABC-type sugar transport system, permease component
DVS28_RS09540	COG1175	transmembrane transport
DVS28_RS09545	COG1653	transport
DVS28_RS09550	COG3328	transposase activity
DVS28_RS09565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DVS28_RS09580	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS09595	COG1116	anion transmembrane transporter activity
DVS28_RS09600	COG3384	dioxygenase
DVS28_RS09610	COG1063	alcohol dehydrogenase
DVS28_RS09625	COG3119	arylsulfatase activity
DVS28_RS09670	COG3415	Transposase
DVS28_RS09670	COG2801	Transposase and inactivated derivatives
DVS28_RS09685	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS09695	COG1024	Enoyl-CoA hydratase
DVS28_RS09710	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS09715	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS09735	COG2124	cytochrome p450
DVS28_RS09740	COG1063	alcohol dehydrogenase
DVS28_RS09775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DVS28_RS09790	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS09795	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS09800	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS09805	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS09830	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS09855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DVS28_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS09885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DVS28_RS09915	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DVS28_RS09920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DVS28_RS09930	COG1414	Transcriptional regulator
DVS28_RS09970	COG0183	Belongs to the thiolase family
DVS28_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS09980	COG2030	dehydratase
DVS28_RS10015	COG1172	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS10025	COG0411	ABC transporter
DVS28_RS10040	COG1022	Amp-dependent synthetase and ligase
DVS28_RS10055	COG3396	Phenylacetate-CoA oxygenase
DVS28_RS10095	COG1024	Enoyl-CoA hydratase
DVS28_RS10110	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS10125	COG0183	Belongs to the thiolase family
DVS28_RS10130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DVS28_RS10155	COG1595	DNA-templated transcription, initiation
DVS28_RS10310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DVS28_RS10315	COG0509	glycine decarboxylation via glycine cleavage system
DVS28_RS10330	COG1686	Belongs to the peptidase S11 family
DVS28_RS10365	COG0756	dUTP diphosphatase activity
DVS28_RS10415	COG2323	membrane
DVS28_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS10455	COG1012	belongs to the aldehyde dehydrogenase family
DVS28_RS10460	COG0515	serine threonine protein kinase
DVS28_RS10460	COG2815	serine threonine protein kinase
DVS28_RS10465	COG1404	Belongs to the peptidase S8 family
DVS28_RS10470	COG0028	Belongs to the TPP enzyme family
DVS28_RS10480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DVS28_RS10535	COG1234	tRNA 3'-trailer cleavage
DVS28_RS10540	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS10540	COG2247	cell wall binding repeat
DVS28_RS10545	COG2364	Membrane
DVS28_RS10575	COG1793	dna ligase
DVS28_RS10580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DVS28_RS10595	COG1643	Atp-dependent helicase
DVS28_RS10610	COG2321	neutral zinc metallopeptidase
DVS28_RS10625	COG0492	ferredoxin-NADP+ reductase activity
DVS28_RS10645	COG3608	succinylglutamate desuccinylase aspartoacylase
DVS28_RS10645	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DVS28_RS10720	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS10735	COG4941	Belongs to the sigma-70 factor family
DVS28_RS10755	COG0604	alcohol dehydrogenase
DVS28_RS10755	COG3321	synthase
DVS28_RS10755	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS10760	COG2409	Drug exporters of the RND superfamily
DVS28_RS10765	COG3851	Histidine kinase
DVS28_RS10810	COG0798	PFAM Bile acid sodium symporter
DVS28_RS10815	COG2385	sporulation resulting in formation of a cellular spore
DVS28_RS10815	COG2247	cell wall binding repeat
DVS28_RS10825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DVS28_RS10860	COG2247	cell wall binding repeat
DVS28_RS10860	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS10875	COG4989	oxidoreductase activity
DVS28_RS10900	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DVS28_RS10910	COG0154	amidase activity
DVS28_RS10920	COG3830	Belongs to the UPF0237 family
DVS28_RS10920	COG0560	Phosphoserine phosphatase
DVS28_RS10945	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DVS28_RS10955	COG1012	belongs to the aldehyde dehydrogenase family
DVS28_RS10965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DVS28_RS10975	COG0740	serine-type endopeptidase activity
DVS28_RS10990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DVS28_RS10995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DVS28_RS11005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DVS28_RS11020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DVS28_RS11025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DVS28_RS11030	COG0737	Belongs to the 5'-nucleotidase family
DVS28_RS11040	COG4251	negative regulation of phosphorylation
DVS28_RS11045	COG0004	ammonium transporteR
DVS28_RS11050	COG0174	glutamine synthetase
DVS28_RS11055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DVS28_RS11065	COG0189	ligase activity
DVS28_RS11065	COG4067	protein conserved in archaea
DVS28_RS11070	COG5640	endopeptidase activity
DVS28_RS11105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DVS28_RS11120	COG0438	transferase activity, transferring glycosyl groups
DVS28_RS11195	COG0668	transmembrane transport
DVS28_RS11205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DVS28_RS11220	COG0508	dehydrogenase complex catalyzes the overall conversion of
DVS28_RS11225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DVS28_RS11230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DVS28_RS11235	COG3608	succinylglutamate desuccinylase aspartoacylase
DVS28_RS11250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DVS28_RS11255	COG1929	Belongs to the glycerate kinase type-1 family
DVS28_RS11280	COG1104	cysteine desulfurase activity
DVS28_RS11285	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DVS28_RS11285	COG0674	pyruvate-flavodoxin oxidoreductase activity
DVS28_RS11290	COG1013	pyruvate-flavodoxin oxidoreductase activity
DVS28_RS11300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DVS28_RS11335	COG0601	transmembrane transport
DVS28_RS11340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DVS28_RS11345	COG0444	Belongs to the ABC transporter superfamily
DVS28_RS11350	COG4608	Belongs to the ABC transporter superfamily
DVS28_RS11365	COG0667	Aldo Keto reductase
DVS28_RS11380	COG0784	Response regulator, receiver
DVS28_RS11385	COG0745	RESPONSE REGULATOR receiver
DVS28_RS11405	COG0501	Belongs to the peptidase M48B family
DVS28_RS11460	COG0495	leucyl-tRNA aminoacylation
DVS28_RS11465	COG1120	ATPase activity
DVS28_RS11470	COG4251	negative regulation of phosphorylation
DVS28_RS11475	COG3590	peptidase
DVS28_RS11500	COG0667	Aldo Keto reductase
DVS28_RS11505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DVS28_RS11555	COG0297	glycogen (starch) synthase activity
DVS28_RS11560	COG2267	carboxylic ester hydrolase activity
DVS28_RS11565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DVS28_RS11570	COG1090	epimerase
DVS28_RS11590	COG1819	glycosyl
DVS28_RS11600	COG0765	amino acid transport
DVS28_RS11605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DVS28_RS11610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DVS28_RS11630	COG0410	ABC transporter
DVS28_RS11655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DVS28_RS11660	COG1120	ATPase activity
DVS28_RS11665	COG1492	cobalamin metabolic process
DVS28_RS11670	COG0113	porphobilinogen synthase activity
DVS28_RS11680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DVS28_RS11695	COG2030	dehydratase
DVS28_RS11725	COG0539	negative regulation of cytoplasmic translation
DVS28_RS11740	COG0237	dephospho-CoA kinase activity
DVS28_RS11745	COG0475	glutathione-regulated potassium exporter activity
DVS28_RS11755	COG2197	response regulator
DVS28_RS11760	COG5002	protein histidine kinase activity
DVS28_RS11800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DVS28_RS11810	COG3608	succinylglutamate desuccinylase aspartoacylase
DVS28_RS11810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DVS28_RS11825	COG1305	Transglutaminase-like
DVS28_RS11835	COG0714	Associated with various cellular activities
DVS28_RS11845	COG1024	Enoyl-CoA hydratase
DVS28_RS11865	COG0556	nucleotide-excision repair
DVS28_RS11885	COG0393	Putative heavy-metal-binding
DVS28_RS11890	COG0393	Putative heavy-metal-binding
DVS28_RS11900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DVS28_RS11905	COG1902	pentaerythritol trinitrate reductase activity
DVS28_RS11910	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS11920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DVS28_RS11940	COG0022	dehydrogenase e1 component
DVS28_RS11965	COG0531	amino acid
DVS28_RS11970	COG0514	ATP-dependent DNA helicase (RecQ)
DVS28_RS11995	COG3328	transposase activity
DVS28_RS12010	COG2264	protein methyltransferase activity
DVS28_RS12025	COG1276	copper resistance
DVS28_RS12055	COG0785	Cytochrome C biogenesis protein
DVS28_RS12095	COG1276	copper resistance
DVS28_RS12100	COG4133	protoheme IX ABC transporter activity
DVS28_RS12110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DVS28_RS12115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DVS28_RS12120	COG1138	Cytochrome C-type biogenesis protein
DVS28_RS12125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DVS28_RS12145	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DVS28_RS12150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DVS28_RS12155	COG0713	ATP synthesis coupled electron transport
DVS28_RS12160	COG0839	Belongs to the complex I subunit 6 family
DVS28_RS12165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DVS28_RS12170	COG0649	NAD binding
DVS28_RS12175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DVS28_RS12210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DVS28_RS12215	COG2124	cytochrome p450
DVS28_RS12220	COG2226	methyltransferase
DVS28_RS12235	COG0789	Transcriptional regulator
DVS28_RS12270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DVS28_RS12315	COG2217	Heavy metal translocating P-type atpase
DVS28_RS12350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DVS28_RS12355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DVS28_RS12380	COG1840	ABC-type Fe3 transport system, periplasmic component
DVS28_RS12400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DVS28_RS12405	COG3842	ATPase activity
DVS28_RS12410	COG0322	excinuclease ABC activity
DVS28_RS12415	COG1660	Displays ATPase and GTPase activities
DVS28_RS12425	COG1481	regulation of sporulation
DVS28_RS12430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DVS28_RS12435	COG0126	phosphoglycerate kinase activity
DVS28_RS12440	COG0149	triose-phosphate isomerase activity
DVS28_RS12450	COG0501	Belongs to the peptidase M48B family
DVS28_RS12460	COG0747	negative chemotaxis
DVS28_RS12465	COG0747	negative chemotaxis
DVS28_RS12470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DVS28_RS12490	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS12495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DVS28_RS12520	COG2843	Capsule synthesis protein
DVS28_RS12545	COG2197	response regulator
DVS28_RS12605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DVS28_RS12625	COG2104	thiamine diphosphate biosynthetic process
DVS28_RS12630	COG0037	tRNA processing
DVS28_RS12645	COG1222	aaa ATPase
DVS28_RS12650	COG1597	lipid kinase activity
DVS28_RS12665	COG4122	O-methyltransferase activity
DVS28_RS12680	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DVS28_RS12685	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DVS28_RS12695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DVS28_RS12715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DVS28_RS12720	COG2378	regulation of single-species biofilm formation
DVS28_RS12735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DVS28_RS12740	COG0805	protein transport
DVS28_RS12750	COG1283	sodium-dependent phosphate transmembrane transporter activity
DVS28_RS12760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DVS28_RS12760	COG0646	methionine synthase
DVS28_RS12765	COG1597	lipid kinase activity
DVS28_RS12770	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DVS28_RS12775	COG1335	isochorismatase
DVS28_RS12790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DVS28_RS12795	COG1802	Transcriptional regulator
DVS28_RS12800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DVS28_RS12805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DVS28_RS12820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DVS28_RS12835	COG0793	Belongs to the peptidase S41A family
DVS28_RS12835	COG4946	Tricorn protease homolog
DVS28_RS12845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DVS28_RS12865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DVS28_RS12880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DVS28_RS12885	COG0254	rRNA binding
DVS28_RS12890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DVS28_RS12895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DVS28_RS12920	COG0513	Belongs to the DEAD box helicase family
DVS28_RS12925	COG0598	Magnesium transport protein CorA
DVS28_RS12930	COG0167	dihydroorotate dehydrogenase activity
DVS28_RS12935	COG2936	dipeptidyl-peptidase activity
DVS28_RS12970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DVS28_RS12980	COG1435	thymidine kinase activity
DVS28_RS12990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DVS28_RS12995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DVS28_RS13000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DVS28_RS13005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DVS28_RS13010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DVS28_RS13015	COG1752	Esterase of the alpha-beta hydrolase superfamily
DVS28_RS13030	COG2072	flavoprotein involved in K transport
DVS28_RS13035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DVS28_RS13040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DVS28_RS13045	COG0477	Major facilitator Superfamily
DVS28_RS13060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DVS28_RS13065	COG1643	Atp-dependent helicase
DVS28_RS13115	COG2873	o-acetylhomoserine
DVS28_RS13120	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DVS28_RS13150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DVS28_RS13155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DVS28_RS13160	COG1120	ATPase activity
DVS28_RS13175	COG0517	IMP dehydrogenase activity
DVS28_RS13185	COG0584	glycerophosphoryl diester phosphodiesterase
DVS28_RS13190	COG0492	ferredoxin-NADP+ reductase activity
DVS28_RS13205	COG0586	Pfam SNARE associated Golgi protein
DVS28_RS13265	COG0714	Associated with various cellular activities
DVS28_RS13275	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DVS28_RS13290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DVS28_RS13305	COG0386	Belongs to the glutathione peroxidase family
DVS28_RS13310	COG1253	flavin adenine dinucleotide binding
DVS28_RS13320	COG1012	belongs to the aldehyde dehydrogenase family
DVS28_RS13330	COG2354	Protein conserved in bacteria
DVS28_RS13340	COG0024	Methionine aminopeptidase
DVS28_RS13375	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DVS28_RS13385	COG0515	serine threonine protein kinase
DVS28_RS13385	COG2815	serine threonine protein kinase
DVS28_RS13390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DVS28_RS13410	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DVS28_RS13430	COG0559	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS13445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DVS28_RS13450	COG0366	Alpha amylase catalytic
DVS28_RS13455	COG1653	transport
DVS28_RS13460	COG1175	transmembrane transport
DVS28_RS13465	COG0395	ABC-type sugar transport system, permease component
DVS28_RS13470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DVS28_RS13495	COG1309	transcriptional regulator
DVS28_RS13500	COG4608	Belongs to the ABC transporter superfamily
DVS28_RS13505	COG0444	Belongs to the ABC transporter superfamily
DVS28_RS13510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DVS28_RS13515	COG0601	transmembrane transport
DVS28_RS13520	COG0747	negative chemotaxis
DVS28_RS13525	COG0714	Associated with various cellular activities
DVS28_RS13535	COG1305	Transglutaminase-like
DVS28_RS13540	COG0667	Aldo Keto reductase
DVS28_RS13545	COG0583	DNA-binding transcription factor activity
DVS28_RS13560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DVS28_RS13575	COG0587	DNA-directed DNA polymerase activity
DVS28_RS13585	COG3663	DNA glycosylase
DVS28_RS13645	COG1024	Enoyl-CoA hydratase
DVS28_RS13660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DVS28_RS13680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DVS28_RS13690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DVS28_RS13715	COG0352	thiamine-phosphate diphosphorylase activity
DVS28_RS13725	COG2022	thiamine diphosphate biosynthetic process
DVS28_RS13735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DVS28_RS13750	COG0515	serine threonine protein kinase
DVS28_RS13750	COG2815	serine threonine protein kinase
DVS28_RS13765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DVS28_RS13770	COG2204	response regulator
DVS28_RS13775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DVS28_RS13780	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DVS28_RS13785	COG0205	6-phosphofructokinase activity
DVS28_RS13820	COG2267	carboxylic ester hydrolase activity
DVS28_RS13830	COG1940	carbohydrate kinase activity
DVS28_RS13845	COG0003	Pfam Anion-transporting ATPase
DVS28_RS13865	COG0705	Rhomboid family
DVS28_RS13885	COG0596	Alpha beta hydrolase
DVS28_RS13890	COG3253	May function as heme-dependent peroxidase
DVS28_RS13895	COG0776	regulation of translation
DVS28_RS13910	COG1011	Hydrolase
DVS28_RS13920	COG0154	amidase activity
DVS28_RS13930	COG4221	oxidoreductase activity
DVS28_RS13935	COG0070	glutamate synthase
DVS28_RS13935	COG0069	glutamate synthase activity
DVS28_RS13935	COG0067	glutamate synthase
DVS28_RS13945	COG2326	polyphosphate kinase activity
DVS28_RS13955	COG1132	(ABC) transporter
DVS28_RS13960	COG0488	(ABC) transporter
DVS28_RS13985	COG1012	belongs to the aldehyde dehydrogenase family
DVS28_RS13995	COG1522	sequence-specific DNA binding
DVS28_RS14010	COG0366	Alpha amylase catalytic
DVS28_RS14015	COG0058	SHG alpha-glucan phosphorylase activity
DVS28_RS14020	COG0366	Alpha amylase catalytic
DVS28_RS14030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DVS28_RS14035	COG0159	tryptophan synthase activity
DVS28_RS14040	COG0133	tryptophan synthase activity
DVS28_RS14045	COG0134	indole-3-glycerol-phosphate synthase activity
DVS28_RS14050	COG0248	Ppx GppA phosphatase
DVS28_RS14060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DVS28_RS14065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DVS28_RS14100	COG2385	sporulation resulting in formation of a cellular spore
DVS28_RS14100	COG2247	cell wall binding repeat
DVS28_RS14110	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS14110	COG2247	cell wall binding repeat
DVS28_RS14120	COG0107	imidazoleglycerol-phosphate synthase activity
DVS28_RS14125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DVS28_RS14130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DVS28_RS14135	COG0131	Imidazoleglycerol-phosphate dehydratase
DVS28_RS14140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DVS28_RS14145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DVS28_RS14155	COG0519	Catalyzes the synthesis of GMP from XMP
DVS28_RS14160	COG2205	protein histidine kinase activity
DVS28_RS14170	COG0517	IMP dehydrogenase activity
DVS28_RS14170	COG0617	tRNA 3'-terminal CCA addition
DVS28_RS14170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DVS28_RS14175	COG0587	DNA-directed DNA polymerase activity
DVS28_RS14180	COG0626	cystathionine gamma-synthase activity
DVS28_RS14185	COG1522	sequence-specific DNA binding
DVS28_RS14195	COG1739	Uncharacterized protein family UPF0029
DVS28_RS14205	COG3268	Saccharopine dehydrogenase
DVS28_RS14220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DVS28_RS14365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DVS28_RS14380	COG3328	transposase activity
DVS28_RS14385	COG1136	(ABC) transporter
DVS28_RS14465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DVS28_RS14485	COG3599	regulation of cell shape
DVS28_RS14495	COG1799	cell septum assembly
DVS28_RS14500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DVS28_RS14505	COG1496	oxidoreductase activity
DVS28_RS14510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DVS28_RS14520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DVS28_RS14525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DVS28_RS14530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DVS28_RS14535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DVS28_RS14545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DVS28_RS14550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DVS28_RS14555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DVS28_RS14560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DVS28_RS14565	COG0768	penicillin binding
DVS28_RS14575	COG0275	rRNA processing
DVS28_RS14580	COG2001	Belongs to the MraZ family
DVS28_RS14590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DVS28_RS14595	COG0204	Acyl-transferase
DVS28_RS14605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DVS28_RS14610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DVS28_RS14615	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS14620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DVS28_RS14635	COG0109	protoheme IX farnesyltransferase activity
DVS28_RS14640	COG1612	heme a metabolic process
DVS28_RS14650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DVS28_RS14675	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DVS28_RS14675	COG0778	Nitroreductase
DVS28_RS14680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DVS28_RS14680	COG1372	Participates in initiation and elongation during chromosome replication
DVS28_RS14685	COG0842	Transport permease protein
DVS28_RS14690	COG1131	(ABC) transporter
DVS28_RS14695	COG1309	transcriptional regulator
DVS28_RS14735	COG0436	Aminotransferase
DVS28_RS14750	COG0702	epimerase
DVS28_RS14795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DVS28_RS14815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DVS28_RS14820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DVS28_RS14830	COG0442	prolyl-tRNA aminoacylation
DVS28_RS14835	COG3300	MHYT domain
DVS28_RS14835	COG5001	Diguanylate cyclase
DVS28_RS14870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DVS28_RS14870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DVS28_RS14890	COG3046	protein related to deoxyribodipyrimidine photolyase
DVS28_RS14905	COG2197	response regulator
DVS28_RS14915	COG2010	Cytochrome c
DVS28_RS14915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DVS28_RS14920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DVS28_RS14945	COG0463	Glycosyl transferase, family 2
DVS28_RS14950	COG0366	Alpha amylase catalytic
DVS28_RS14965	COG2902	Dehydrogenase
DVS28_RS14980	COG0589	response to stress
DVS28_RS14985	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DVS28_RS14990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DVS28_RS15030	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DVS28_RS15095	COG2838	Isocitrate dehydrogenase
DVS28_RS15125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DVS28_RS15130	COG0358	DNA primase activity
DVS28_RS15135	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DVS28_RS15145	COG0423	glycine-tRNA ligase activity
DVS28_RS15150	COG1309	transcriptional regulator
DVS28_RS15155	COG1126	abc transporter atp-binding protein
DVS28_RS15160	COG0765	amino acid transport
DVS28_RS15165	COG4597	amino acid ABC transporter
DVS28_RS15170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DVS28_RS15180	COG1012	belongs to the aldehyde dehydrogenase family
DVS28_RS15205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DVS28_RS15210	COG1381	Involved in DNA repair and RecF pathway recombination
DVS28_RS15235	COG2197	response regulator
DVS28_RS15275	COG1316	TRANSCRIPTIONal
DVS28_RS15295	COG1253	flavin adenine dinucleotide binding
DVS28_RS15310	COG1556	Lactate utilization protein
DVS28_RS15315	COG1139	Iron-sulfur cluster binding protein
DVS28_RS15320	COG0247	lactate metabolic process
DVS28_RS15325	COG1609	Transcriptional regulator
DVS28_RS15330	COG1129	ABC transporter
DVS28_RS15335	COG1172	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS15340	COG1172	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS15355	COG4952	isomerase
DVS28_RS15360	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS15360	COG3347	Dehydrogenase
DVS28_RS15365	COG1070	Carbohydrate kinase
DVS28_RS15375	COG3250	beta-galactosidase activity
DVS28_RS15385	COG0243	molybdopterin cofactor binding
DVS28_RS15395	COG2146	nitrite reductase [NAD(P)H] activity
DVS28_RS15395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DVS28_RS15400	COG2146	nitrite reductase [NAD(P)H] activity
DVS28_RS15400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DVS28_RS15405	COG2223	nitrite transmembrane transporter activity
DVS28_RS15410	COG1902	pentaerythritol trinitrate reductase activity
DVS28_RS15410	COG0446	pyridine nucleotide-disulphide oxidoreductase
DVS28_RS15415	COG5002	protein histidine kinase activity
DVS28_RS15415	COG0784	Response regulator, receiver
DVS28_RS15425	COG2202	Pas domain
DVS28_RS15425	COG2205	protein histidine kinase activity
DVS28_RS15430	COG0456	acetyltransferase
DVS28_RS15445	COG0822	iron-sulfur transferase activity
DVS28_RS15450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DVS28_RS15455	COG0396	ATPase activity
DVS28_RS15465	COG0719	Fe-S assembly protein
DVS28_RS15470	COG0719	Fe-S assembly protein
DVS28_RS15480	COG0517	IMP dehydrogenase activity
DVS28_RS15480	COG1125	glycine betaine transport
DVS28_RS15485	COG1174	glycine betaine transport
DVS28_RS15490	COG1174	glycine betaine transport
DVS28_RS15495	COG1732	Glycine betaine
DVS28_RS15500	COG0745	RESPONSE REGULATOR receiver
DVS28_RS15505	COG1098	S1 RNA binding domain
DVS28_RS15515	COG2247	cell wall binding repeat
DVS28_RS15515	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS15520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DVS28_RS15530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DVS28_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS15540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DVS28_RS15545	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS15555	COG0009	L-threonylcarbamoyladenylate synthase
DVS28_RS15560	COG1970	mechanosensitive ion channel activity
DVS28_RS15575	COG0412	Dienelactone hydrolase
DVS28_RS15585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DVS28_RS15590	COG2501	S4 domain
DVS28_RS15640	COG0166	Belongs to the GPI family
DVS28_RS15675	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS15710	COG2267	carboxylic ester hydrolase activity
DVS28_RS15775	COG0561	phosphatase activity
DVS28_RS15795	COG0012	GTP binding
DVS28_RS15850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DVS28_RS15860	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS15865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DVS28_RS15885	COG0697	spore germination
DVS28_RS15890	COG0277	FAD linked oxidase domain protein
DVS28_RS15910	COG0657	acetylesterase activity
DVS28_RS15915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DVS28_RS15925	COG1217	gtp-binding protein TYPA
DVS28_RS15935	COG2205	protein histidine kinase activity
DVS28_RS15935	COG2198	Histidine kinase
DVS28_RS15935	COG0784	Response regulator, receiver
DVS28_RS15980	COG1501	Belongs to the glycosyl hydrolase 31 family
DVS28_RS15985	COG3387	PFAM Glycoside hydrolase 15-related
DVS28_RS15990	COG1653	transport
DVS28_RS15995	COG0395	ABC-type sugar transport system, permease component
DVS28_RS16000	COG1175	transmembrane transport
DVS28_RS16005	COG1846	Transcriptional regulator
DVS28_RS16005	COG1940	carbohydrate kinase activity
DVS28_RS16010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DVS28_RS16020	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS16025	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS16035	COG1678	Uncharacterized ACR, COG1678
DVS28_RS16040	COG1309	transcriptional regulator
DVS28_RS16075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DVS28_RS16150	COG1129	ABC transporter
DVS28_RS16155	COG4603	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS16160	COG1079	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS16165	COG3467	pyridoxamine 5'-phosphate
DVS28_RS16170	COG0432	Pfam Uncharacterised protein family UPF0047
DVS28_RS16220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DVS28_RS16230	COG3258	Cytochrome c
DVS28_RS16245	COG2217	Heavy metal translocating P-type atpase
DVS28_RS16250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DVS28_RS16255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DVS28_RS16275	COG4214	carbohydrate transport
DVS28_RS16300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DVS28_RS16305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DVS28_RS16310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DVS28_RS16315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DVS28_RS16325	COG2137	regulation of response to DNA damage stimulus
DVS28_RS16330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DVS28_RS16345	COG1546	Belongs to the CinA family
DVS28_RS16345	COG1058	Belongs to the CinA family
DVS28_RS16350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DVS28_RS16355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DVS28_RS16365	COG2066	Belongs to the glutaminase family
DVS28_RS16370	COG1127	ABC transporter
DVS28_RS16415	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DVS28_RS16430	COG2201	protein-glutamate methylesterase activity
DVS28_RS16435	COG2372	response to copper ion
DVS28_RS16435	COG1276	copper resistance
DVS28_RS16445	COG1674	ftsk spoiiie
DVS28_RS16450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DVS28_RS16455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DVS28_RS16465	COG1271	oxidase subunit
DVS28_RS16470	COG1294	oxidase, subunit
DVS28_RS16500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DVS28_RS16505	COG0215	cysteine-tRNA ligase activity
DVS28_RS16510	COG1280	lysine exporter protein (LysE YggA)
DVS28_RS16515	COG0612	Peptidase, M16
DVS28_RS16520	COG1185	polyribonucleotide nucleotidyltransferase activity
DVS28_RS16525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DVS28_RS16530	COG2247	cell wall binding repeat
DVS28_RS16530	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS16535	COG1404	Belongs to the peptidase S8 family
DVS28_RS16555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DVS28_RS16560	COG2205	protein histidine kinase activity
DVS28_RS16560	COG2202	Pas domain
DVS28_RS16565	COG2197	response regulator
DVS28_RS16575	COG2111	Na H antiporter
DVS28_RS16575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DVS28_RS16590	COG0651	ATP synthesis coupled electron transport
DVS28_RS16615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DVS28_RS16625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DVS28_RS16655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DVS28_RS16665	COG0779	Required for maturation of 30S ribosomal subunits
DVS28_RS16680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DVS28_RS16690	COG1136	(ABC) transporter
DVS28_RS16690	COG0577	efflux transmembrane transporter activity
DVS28_RS16700	COG0483	inositol monophosphate 1-phosphatase activity
DVS28_RS16705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DVS28_RS16725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DVS28_RS16730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DVS28_RS16735	COG4589	Belongs to the CDS family
DVS28_RS16740	COG0233	cytoplasmic translational termination
DVS28_RS16745	COG0528	UMP kinase activity
DVS28_RS16750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DVS28_RS16755	COG0052	Belongs to the universal ribosomal protein uS2 family
DVS28_RS16770	COG1191	sigma factor activity
DVS28_RS16780	COG0758	DNA mediated transformation
DVS28_RS16780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DVS28_RS16790	COG0792	nuclease activity
DVS28_RS16795	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS16795	COG2247	cell wall binding repeat
DVS28_RS16815	COG0681	Belongs to the peptidase S26 family
DVS28_RS16820	COG0335	large ribosomal subunit rRNA binding
DVS28_RS16825	COG0681	Belongs to the peptidase S26 family
DVS28_RS16830	COG0336	Belongs to the RNA methyltransferase TrmD family
DVS28_RS16835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DVS28_RS16845	COG0228	four-way junction DNA binding
DVS28_RS16860	COG3300	MHYT domain
DVS28_RS16860	COG5001	Diguanylate cyclase
DVS28_RS16865	COG1404	Belongs to the peptidase S8 family
DVS28_RS16875	COG1404	Belongs to the peptidase S8 family
DVS28_RS16880	COG1404	Belongs to the peptidase S8 family
DVS28_RS16905	COG1131	(ABC) transporter
DVS28_RS16915	COG3177	Filamentation induced by cAMP protein fic
DVS28_RS16920	COG0552	protein localization to endoplasmic reticulum
DVS28_RS16945	COG2267	carboxylic ester hydrolase activity
DVS28_RS16955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DVS28_RS16960	COG0571	ribonuclease III activity
DVS28_RS16965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DVS28_RS16970	COG0416	fatty acid biosynthetic process
DVS28_RS16975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DVS28_RS16990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DVS28_RS16995	COG0742	ribosomal rna small subunit methyltransferase
DVS28_RS17005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DVS28_RS17010	COG0351	phosphomethylpyrimidine kinase
DVS28_RS17015	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DVS28_RS17020	COG3547	Transposase (IS116 IS110 IS902 family)
DVS28_RS17030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DVS28_RS17050	COG1181	Belongs to the D-alanine--D-alanine ligase family
DVS28_RS17055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DVS28_RS17065	COG1920	GTP binding
DVS28_RS17085	COG2339	peptidase activity
DVS28_RS17110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DVS28_RS17125	COG0179	Fumarylacetoacetate (FAA) hydrolase
DVS28_RS17135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DVS28_RS17150	COG3263	regulation of cellular component size
DVS28_RS17155	COG0205	6-phosphofructokinase activity
DVS28_RS17165	COG0446	pyridine nucleotide-disulphide oxidoreductase
DVS28_RS17175	COG0473	3-isopropylmalate dehydrogenase activity
DVS28_RS17185	COG0456	acetyltransferase
DVS28_RS17195	COG0494	nUDIX hydrolase
DVS28_RS17195	COG0406	alpha-ribazole phosphatase activity
DVS28_RS17210	COG2132	Multicopper oxidase
DVS28_RS17220	COG1595	DNA-templated transcription, initiation
DVS28_RS17235	COG4941	Belongs to the sigma-70 factor family
DVS28_RS17240	COG0596	Alpha beta hydrolase
DVS28_RS17245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DVS28_RS17275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DVS28_RS17285	COG0066	3-isopropylmalate dehydratase activity
DVS28_RS17290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DVS28_RS17300	COG0175	sulfate reduction
DVS28_RS17305	COG3300	MHYT domain
DVS28_RS17305	COG5001	Diguanylate cyclase
DVS28_RS17310	COG2323	membrane
DVS28_RS17350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DVS28_RS17355	COG3833	ABC-type maltose transport systems, permease component
DVS28_RS17360	COG1175	transmembrane transport
DVS28_RS17390	COG2197	response regulator
DVS28_RS17415	COG4172	Belongs to the ABC transporter superfamily
DVS28_RS17420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DVS28_RS17430	COG4533	DNA binding
DVS28_RS17435	COG3328	transposase activity
DVS28_RS17450	COG0824	Thioesterase
DVS28_RS17475	COG0489	protein tyrosine kinase activity
DVS28_RS17490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DVS28_RS17495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DVS28_RS17505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DVS28_RS17510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DVS28_RS17515	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DVS28_RS17595	COG3629	intracellular signal transduction
DVS28_RS17605	COG4152	abc transporter atp-binding protein
DVS28_RS17610	COG4585	Histidine kinase
DVS28_RS17615	COG2197	response regulator
DVS28_RS17620	COG2130	NADP-dependent
DVS28_RS17635	COG2843	Capsule synthesis protein
DVS28_RS17670	COG1136	(ABC) transporter
DVS28_RS17670	COG0577	efflux transmembrane transporter activity
DVS28_RS17690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DVS28_RS17695	COG0662	Cupin 2, conserved barrel domain protein
DVS28_RS17700	COG0508	dehydrogenase complex catalyzes the overall conversion of
DVS28_RS17725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DVS28_RS17735	COG1131	(ABC) transporter
DVS28_RS17745	COG1022	Amp-dependent synthetase and ligase
DVS28_RS17750	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DVS28_RS17755	COG0829	nickel cation binding
DVS28_RS17760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DVS28_RS17765	COG0830	nickel cation binding
DVS28_RS17770	COG0804	urea catabolic process
DVS28_RS17775	COG0831	urea catabolic process
DVS28_RS17775	COG0832	Belongs to the urease beta subunit family
DVS28_RS17795	COG4266	Belongs to the allantoicase family
DVS28_RS17800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DVS28_RS17835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DVS28_RS17870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DVS28_RS17875	COG0440	acetolactate synthase activity
DVS28_RS17885	COG1472	Belongs to the glycosyl hydrolase 3 family
DVS28_RS17890	COG1304	FMN binding
DVS28_RS17910	COG0142	geranyltranstransferase activity
DVS28_RS17920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DVS28_RS17925	COG0154	amidase activity
DVS28_RS17930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DVS28_RS17935	COG0596	Alpha beta hydrolase
DVS28_RS17945	COG2304	oxidoreductase activity
DVS28_RS17955	COG0714	Associated with various cellular activities
DVS28_RS17985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DVS28_RS17995	COG2378	regulation of single-species biofilm formation
DVS28_RS18000	COG0596	Alpha beta hydrolase
DVS28_RS18005	COG0482	sulfurtransferase activity
DVS28_RS18015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DVS28_RS18025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DVS28_RS18030	COG0601	transmembrane transport
DVS28_RS18035	COG0747	negative chemotaxis
DVS28_RS18045	COG0444	Belongs to the ABC transporter superfamily
DVS28_RS18050	COG4608	Belongs to the ABC transporter superfamily
DVS28_RS18075	COG1131	(ABC) transporter
DVS28_RS18080	COG0842	Transport permease protein
DVS28_RS18080	COG1129	ABC transporter
DVS28_RS18100	COG0596	Alpha beta hydrolase
DVS28_RS18115	COG0783	Belongs to the Dps family
DVS28_RS18125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DVS28_RS18140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DVS28_RS18145	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS18160	COG1543	Belongs to the glycosyl hydrolase 57 family
DVS28_RS18170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DVS28_RS18170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DVS28_RS18185	COG0577	efflux transmembrane transporter activity
DVS28_RS18185	COG1136	(ABC) transporter
DVS28_RS18190	COG0577	efflux transmembrane transporter activity
DVS28_RS18190	COG1136	(ABC) transporter
DVS28_RS18205	COG0745	RESPONSE REGULATOR receiver
DVS28_RS18210	COG2205	protein histidine kinase activity
DVS28_RS18235	COG0110	maltose O-acetyltransferase activity
DVS28_RS18255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DVS28_RS18270	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS18275	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS18290	COG0515	serine threonine protein kinase
DVS28_RS18290	COG2815	serine threonine protein kinase
DVS28_RS18315	COG1703	isobutyryl-CoA mutase activity
DVS28_RS18320	COG0183	Belongs to the thiolase family
DVS28_RS18355	COG0346	lactoylglutathione lyase activity
DVS28_RS18370	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS18370	COG2247	cell wall binding repeat
DVS28_RS18375	COG0243	molybdopterin cofactor binding
DVS28_RS18375	COG3383	formate dehydrogenase (NAD+) activity
DVS28_RS18380	COG3383	formate dehydrogenase (NAD+) activity
DVS28_RS18380	COG0243	molybdopterin cofactor binding
DVS28_RS18385	COG0437	4 iron, 4 sulfur cluster binding
DVS28_RS18415	COG1250	3-hydroxyacyl-CoA dehydrogenase
DVS28_RS18435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DVS28_RS18440	COG2205	protein histidine kinase activity
DVS28_RS18455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DVS28_RS18460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DVS28_RS18465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DVS28_RS18470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DVS28_RS18475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DVS28_RS18480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DVS28_RS18485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DVS28_RS18490	COG0356	it plays a direct role in the translocation of protons across the membrane
DVS28_RS18510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DVS28_RS18525	COG0698	ribose 5-phosphate isomerase
DVS28_RS18545	COG2890	protein-(glutamine-N5) methyltransferase activity
DVS28_RS18550	COG0655	NAD(P)H dehydrogenase (quinone) activity
DVS28_RS18560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DVS28_RS18565	COG3872	metal-dependent enzyme
DVS28_RS18575	COG0083	homoserine kinase activity
DVS28_RS18580	COG0460	homoserine dehydrogenase
DVS28_RS18590	COG0018	arginyl-trna synthetase
DVS28_RS18595	COG0745	RESPONSE REGULATOR receiver
DVS28_RS18625	COG2267	carboxylic ester hydrolase activity
DVS28_RS18655	COG0714	Associated with various cellular activities
DVS28_RS18680	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS18690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DVS28_RS18705	COG0748	coenzyme F420 binding
DVS28_RS18715	COG1522	sequence-specific DNA binding
DVS28_RS18720	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DVS28_RS18725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DVS28_RS18735	COG0259	pyridoxamine-phosphate oxidase activity
DVS28_RS18745	COG1404	Belongs to the peptidase S8 family
DVS28_RS18750	COG0596	Alpha beta hydrolase
DVS28_RS18760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DVS28_RS18785	COG3842	ATPase activity
DVS28_RS18830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DVS28_RS18840	COG3415	Transposase
DVS28_RS18840	COG2801	Transposase and inactivated derivatives
DVS28_RS18865	COG0745	RESPONSE REGULATOR receiver
DVS28_RS18870	COG0469	pyruvate kinase activity
DVS28_RS18895	COG1079	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS18900	COG4603	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS18905	COG3845	ABC transporter
DVS28_RS18910	COG1744	ABC transporter substrate-binding protein PnrA-like
DVS28_RS18915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DVS28_RS18920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DVS28_RS18930	COG0745	RESPONSE REGULATOR receiver
DVS28_RS18935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DVS28_RS18950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DVS28_RS18960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DVS28_RS18970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DVS28_RS18980	COG5002	protein histidine kinase activity
DVS28_RS19000	COG2267	carboxylic ester hydrolase activity
DVS28_RS19005	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DVS28_RS19010	COG1494	fructose-1,6-bisphosphatase
DVS28_RS19015	COG1024	Enoyl-CoA hydratase
DVS28_RS19020	COG0784	Response regulator, receiver
DVS28_RS19025	COG4251	negative regulation of phosphorylation
DVS28_RS19030	COG3706	GGDEF domain
DVS28_RS19060	COG0642	Histidine kinase
DVS28_RS19065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DVS28_RS19080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DVS28_RS19085	COG3572	ergothioneine biosynthetic process
DVS28_RS19090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DVS28_RS19095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DVS28_RS19100	COG3572	ergothioneine biosynthetic process
DVS28_RS19105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DVS28_RS19115	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DVS28_RS19125	COG0243	molybdopterin cofactor binding
DVS28_RS19130	COG0557	exoribonuclease II activity
DVS28_RS19170	COG0842	Transport permease protein
DVS28_RS19170	COG1716	ATPase activity
DVS28_RS19170	COG1131	(ABC) transporter
DVS28_RS19175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DVS28_RS19180	COG2247	cell wall binding repeat
DVS28_RS19180	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS19235	COG1522	sequence-specific DNA binding
DVS28_RS19240	COG0686	Belongs to the AlaDH PNT family
DVS28_RS19265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DVS28_RS19265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DVS28_RS19270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DVS28_RS19275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DVS28_RS19310	COG0114	fumarate hydratase activity
DVS28_RS19320	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS19320	COG2247	cell wall binding repeat
DVS28_RS19325	COG0475	glutathione-regulated potassium exporter activity
DVS28_RS19335	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DVS28_RS19345	COG2197	response regulator
DVS28_RS19355	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS19370	COG0745	RESPONSE REGULATOR receiver
DVS28_RS19380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DVS28_RS19405	COG0148	phosphopyruvate hydratase activity
DVS28_RS19410	COG1609	Transcriptional regulator
DVS28_RS19415	COG3956	TIGRFAM MazG family protein
DVS28_RS19420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DVS28_RS19430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DVS28_RS19435	COG0193	aminoacyl-tRNA hydrolase activity
DVS28_RS19440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DVS28_RS19450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DVS28_RS19460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DVS28_RS19465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DVS28_RS19470	COG0084	hydrolase, TatD family'
DVS28_RS19475	COG2002	toxin-antitoxin pair type II binding
DVS28_RS19485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DVS28_RS19505	COG2226	methyltransferase
DVS28_RS19520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DVS28_RS19525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DVS28_RS19540	COG0561	phosphatase activity
DVS28_RS19575	COG0521	Mo-molybdopterin cofactor biosynthetic process
DVS28_RS19580	COG0315	cyclic pyranopterin monophosphate synthase activity
DVS28_RS19590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DVS28_RS19595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DVS28_RS19605	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DVS28_RS19610	COG0789	Transcriptional regulator
DVS28_RS19620	COG1968	undecaprenyl-diphosphatase activity
DVS28_RS19625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DVS28_RS19635	COG0346	lactoylglutathione lyase activity
DVS28_RS19640	COG0640	Transcriptional regulator
DVS28_RS19665	COG0604	alcohol dehydrogenase
DVS28_RS19675	COG2801	Transposase and inactivated derivatives
DVS28_RS19675	COG3415	Transposase
DVS28_RS19680	COG0210	DNA helicase
DVS28_RS19735	COG1525	nuclease
DVS28_RS19750	COG0577	efflux transmembrane transporter activity
DVS28_RS19755	COG0577	efflux transmembrane transporter activity
DVS28_RS19755	COG1136	(ABC) transporter
DVS28_RS19760	COG2197	response regulator
DVS28_RS19765	COG4585	Histidine kinase
DVS28_RS19795	COG1213	nucleotidyl transferase
DVS28_RS19795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DVS28_RS19800	COG3547	Transposase (IS116 IS110 IS902 family)
DVS28_RS19805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DVS28_RS19820	COG4191	Histidine kinase
DVS28_RS19825	COG0129	dihydroxy-acid dehydratase activity
DVS28_RS19835	COG2385	sporulation resulting in formation of a cellular spore
DVS28_RS19835	COG2247	cell wall binding repeat
DVS28_RS19840	COG0741	lytic transglycosylase activity
DVS28_RS19885	COG0745	RESPONSE REGULATOR receiver
DVS28_RS19895	COG2030	dehydratase
DVS28_RS19910	COG1842	Phage shock protein A
DVS28_RS19930	COG0464	growth
DVS28_RS19945	COG0235	Class ii aldolase
DVS28_RS19945	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DVS28_RS19960	COG2199	diguanylate cyclase activity
DVS28_RS20025	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DVS28_RS20030	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DVS28_RS20035	COG4956	integral membrane protein (PIN domain superfamily)
DVS28_RS20040	COG1329	Transcriptional regulator
DVS28_RS20045	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DVS28_RS20050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DVS28_RS20070	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DVS28_RS20105	COG4941	Belongs to the sigma-70 factor family
DVS28_RS20110	COG3795	YCII-related domain
DVS28_RS20115	COG3795	YCII-related domain
DVS28_RS20120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DVS28_RS20130	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DVS28_RS20140	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DVS28_RS20145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DVS28_RS20160	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DVS28_RS20165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DVS28_RS20170	COG2247	cell wall binding repeat
DVS28_RS20170	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS20180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DVS28_RS20185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DVS28_RS20190	COG0302	gtp cyclohydrolase
DVS28_RS20195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DVS28_RS20205	COG0037	tRNA processing
DVS28_RS20235	COG1131	(ABC) transporter
DVS28_RS20260	COG1940	carbohydrate kinase activity
DVS28_RS20270	COG3842	ATPase activity
DVS28_RS20275	COG0395	ABC-type sugar transport system, permease component
DVS28_RS20280	COG1175	transmembrane transport
DVS28_RS20295	COG1349	DNA-binding transcription factor activity
DVS28_RS20300	COG0483	inositol monophosphate 1-phosphatase activity
DVS28_RS20310	COG1058	Belongs to the CinA family
DVS28_RS20310	COG1546	Belongs to the CinA family
DVS28_RS20325	COG1376	ErfK ybiS ycfS ynhG family protein
DVS28_RS20355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DVS28_RS20365	COG0803	Belongs to the bacterial solute-binding protein 9 family
DVS28_RS20420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DVS28_RS20445	COG2801	Transposase and inactivated derivatives
DVS28_RS20465	COG1228	amidohydrolase
DVS28_RS20470	COG0402	S-adenosylhomocysteine deaminase activity
DVS28_RS20485	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DVS28_RS20510	COG2267	carboxylic ester hydrolase activity
DVS28_RS20525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DVS28_RS20560	COG2072	flavoprotein involved in K transport
DVS28_RS20570	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DVS28_RS20585	COG2124	cytochrome p450
DVS28_RS20610	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS20615	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS20630	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS20630	COG2247	cell wall binding repeat
DVS28_RS20635	COG0477	Major facilitator Superfamily
DVS28_RS20645	COG1024	Enoyl-CoA hydratase
DVS28_RS20650	COG0183	Belongs to the thiolase family
DVS28_RS20675	COG5001	Diguanylate cyclase
DVS28_RS20690	COG1250	3-hydroxyacyl-CoA dehydrogenase
DVS28_RS20700	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS20715	COG2186	Transcriptional regulator
DVS28_RS20720	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS20735	COG1024	Enoyl-CoA hydratase
DVS28_RS20755	COG1053	succinate dehydrogenase
DVS28_RS20760	COG2261	transglycosylase associated protein
DVS28_RS20805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DVS28_RS20860	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS20890	COG2267	carboxylic ester hydrolase activity
DVS28_RS20905	COG2124	cytochrome p450
DVS28_RS20915	COG2146	nitrite reductase [NAD(P)H] activity
DVS28_RS20920	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS20930	COG1268	BioY protein
DVS28_RS20950	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS20955	COG0183	Belongs to the thiolase family
DVS28_RS20965	COG4770	biotin carboxylase activity
DVS28_RS20990	COG1053	succinate dehydrogenase
DVS28_RS21005	COG1672	PFAM Archaeal ATPase
DVS28_RS21005	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DVS28_RS21025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DVS28_RS21050	COG0475	glutathione-regulated potassium exporter activity
DVS28_RS21055	COG0490	domain, Protein
DVS28_RS21065	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
DVS28_RS21075	COG2373	Large extracellular alpha-helical protein
DVS28_RS21085	COG0191	fructose-bisphosphate aldolase activity
DVS28_RS21115	COG2337	Toxic component of a toxin-antitoxin (TA) module
DVS28_RS21125	COG2203	Gaf domain
DVS28_RS21125	COG3706	GGDEF domain
DVS28_RS21125	COG4251	negative regulation of phosphorylation
DVS28_RS21125	COG5001	Diguanylate cyclase
DVS28_RS21155	COG0667	Aldo Keto reductase
DVS28_RS21160	COG2154	pterin-4-alpha-carbinolamine dehydratase
DVS28_RS21180	COG4413	Urea transporter
DVS28_RS21185	COG0829	nickel cation binding
DVS28_RS21195	COG0830	nickel cation binding
DVS28_RS21200	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DVS28_RS21210	COG0804	urea catabolic process
DVS28_RS21215	COG0832	Belongs to the urease beta subunit family
DVS28_RS21215	COG0831	urea catabolic process
DVS28_RS21230	COG3328	transposase activity
DVS28_RS21255	COG1473	amidohydrolase
DVS28_RS21270	COG0735	belongs to the Fur family
DVS28_RS21285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DVS28_RS21295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DVS28_RS21300	COG0601	transmembrane transport
DVS28_RS21315	COG3485	protocatechuate 3,4-dioxygenase
DVS28_RS21325	COG4948	Mandelate Racemase Muconate Lactonizing
DVS28_RS21335	COG1454	alcohol dehydrogenase
DVS28_RS21340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DVS28_RS21345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DVS28_RS21390	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DVS28_RS21395	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DVS28_RS21410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DVS28_RS21415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DVS28_RS21415	COG1754	DNA topoisomerase type I activity
DVS28_RS21420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DVS28_RS21425	COG1404	Belongs to the peptidase S8 family
DVS28_RS21430	COG5001	Diguanylate cyclase
DVS28_RS21435	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DVS28_RS21445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DVS28_RS21475	COG2172	sigma factor antagonist activity
DVS28_RS21480	COG1366	Belongs to the anti-sigma-factor antagonist family
DVS28_RS21555	COG4251	negative regulation of phosphorylation
DVS28_RS21560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DVS28_RS21570	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS21595	COG0435	Glutathione S-transferase
DVS28_RS21620	COG3547	Transposase (IS116 IS110 IS902 family)
DVS28_RS21625	COG1473	amidohydrolase
DVS28_RS21650	COG0508	dehydrogenase complex catalyzes the overall conversion of
DVS28_RS21650	COG0567	Dehydrogenase, E1 component
DVS28_RS21655	COG1362	aminopeptidase activity
DVS28_RS21665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DVS28_RS21670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DVS28_RS21670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DVS28_RS21675	COG0736	holo-[acyl-carrier-protein] synthase activity
DVS28_RS21680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DVS28_RS21705	COG1136	(ABC) transporter
DVS28_RS21715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DVS28_RS21720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DVS28_RS21730	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DVS28_RS21780	COG2382	esterase
DVS28_RS21790	COG1136	(ABC) transporter
DVS28_RS21790	COG4591	ABC-type transport system involved in lipoprotein release permease component
DVS28_RS21845	COG1940	carbohydrate kinase activity
DVS28_RS21850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DVS28_RS21855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DVS28_RS21860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DVS28_RS21865	COG0693	protein deglycase activity
DVS28_RS21875	COG0101	tRNA pseudouridine synthase activity
DVS28_RS21880	COG0203	ribosomal protein L17
DVS28_RS21885	COG0202	RNA polymerase activity
DVS28_RS21890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DVS28_RS21895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DVS28_RS21900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DVS28_RS21910	COG0561	phosphatase activity
DVS28_RS21915	COG0563	adenylate kinase activity
DVS28_RS21925	COG0200	Binds to the 23S rRNA
DVS28_RS21930	COG1841	ribosomal large subunit assembly
DVS28_RS21935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DVS28_RS21940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DVS28_RS21945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DVS28_RS21950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DVS28_RS21955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DVS28_RS21960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DVS28_RS21965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DVS28_RS21970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DVS28_RS21975	COG0255	Belongs to the universal ribosomal protein uL29 family
DVS28_RS21985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DVS28_RS21990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DVS28_RS21995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DVS28_RS22000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DVS28_RS22005	COG0089	rRNA binding
DVS28_RS22010	COG0088	Forms part of the polypeptide exit tunnel
DVS28_RS22015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DVS28_RS22020	COG0051	transcription antitermination factor activity, RNA binding
DVS28_RS22025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DVS28_RS22030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DVS28_RS22035	COG0049	tRNA binding
DVS28_RS22040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DVS28_RS22060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DVS28_RS22065	COG1797	cobyrinic acid a,c-diamide synthase activity
DVS28_RS22090	COG0708	Exodeoxyribonuclease III
DVS28_RS22115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DVS28_RS22120	COG0085	RNA polymerase activity
DVS28_RS22125	COG0222	ribosome binding
DVS28_RS22130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DVS28_RS22135	COG1454	alcohol dehydrogenase
DVS28_RS22135	COG1012	belongs to the aldehyde dehydrogenase family
DVS28_RS22165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DVS28_RS22175	COG0081	regulation of translation
DVS28_RS22180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DVS28_RS22190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DVS28_RS22205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DVS28_RS22225	COG1666	GTP binding
DVS28_RS22240	COG1007	ATP synthesis coupled electron transport
DVS28_RS22250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DVS28_RS22255	COG0713	ATP synthesis coupled electron transport
DVS28_RS22265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DVS28_RS22270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DVS28_RS22275	COG0649	NAD binding
DVS28_RS22280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DVS28_RS22285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DVS28_RS22290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DVS28_RS22330	COG0142	geranyltranstransferase activity
DVS28_RS22350	COG0713	ATP synthesis coupled electron transport
DVS28_RS22365	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DVS28_RS22370	COG1034	ATP synthesis coupled electron transport
DVS28_RS22375	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DVS28_RS22385	COG0649	NAD binding
DVS28_RS22390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DVS28_RS22400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DVS28_RS22405	COG2814	Major facilitator Superfamily
DVS28_RS22430	COG2081	HI0933 family
DVS28_RS22480	COG1174	glycine betaine transport
DVS28_RS22515	COG0427	acetyl-CoA hydrolase
DVS28_RS22540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DVS28_RS22545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DVS28_RS22550	COG2226	methyltransferase
DVS28_RS22555	COG0402	S-adenosylhomocysteine deaminase activity
DVS28_RS22570	COG1169	isochorismate synthase
DVS28_RS22580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DVS28_RS22585	COG4948	Mandelate Racemase Muconate Lactonizing
DVS28_RS22620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DVS28_RS22620	COG2755	lipolytic protein G-D-S-L family
DVS28_RS22625	COG1794	racemase activity, acting on amino acids and derivatives
DVS28_RS22630	COG0668	transmembrane transport
DVS28_RS22640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DVS28_RS22660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DVS28_RS22665	COG1333	cytochrome c biogenesis protein
DVS28_RS22670	COG0785	Cytochrome C biogenesis protein
DVS28_RS22700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DVS28_RS22715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DVS28_RS22720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DVS28_RS22725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DVS28_RS22730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DVS28_RS22770	COG0181	hydroxymethylbilane synthase activity
DVS28_RS22775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DVS28_RS22785	COG1960	acyl-CoA dehydrogenase activity
DVS28_RS22805	COG0542	response to heat
DVS28_RS22810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DVS28_RS22815	COG0573	inorganic phosphate transmembrane transporter activity
DVS28_RS22820	COG0581	inorganic phosphate transmembrane transporter activity
DVS28_RS22830	COG2308	Evidence 4 Homologs of previously reported genes of
DVS28_RS22845	COG2308	Evidence 4 Homologs of previously reported genes of
DVS28_RS22845	COG2307	Protein conserved in bacteria
DVS28_RS22860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DVS28_RS22895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DVS28_RS22910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DVS28_RS22925	COG1063	alcohol dehydrogenase
DVS28_RS22935	COG0457	Tetratricopeptide repeat
DVS28_RS22935	COG0463	Glycosyl transferase, family 2
DVS28_RS22960	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS22965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DVS28_RS22990	COG0183	Belongs to the thiolase family
DVS28_RS23005	COG0010	Belongs to the arginase family
DVS28_RS23015	COG4232	protein-disulfide reductase activity
DVS28_RS23020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DVS28_RS23035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DVS28_RS23050	COG0735	belongs to the Fur family
DVS28_RS23055	COG0310	cobalt ion transport
DVS28_RS23065	COG1122	ATPase activity
DVS28_RS23110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DVS28_RS23115	COG2936	dipeptidyl-peptidase activity
DVS28_RS23135	COG0537	adenosine 5'-monophosphoramidase activity
DVS28_RS23150	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS23185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DVS28_RS23190	COG4399	Belongs to the UPF0754 family
DVS28_RS23200	COG0463	Glycosyl transferase, family 2
DVS28_RS23205	COG0626	cystathionine gamma-synthase activity
DVS28_RS23215	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS23235	COG2267	carboxylic ester hydrolase activity
DVS28_RS23240	COG1830	Aldolase
DVS28_RS23265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DVS28_RS23275	COG0436	Aminotransferase
DVS28_RS23285	COG1879	ABC-type sugar transport system periplasmic component
DVS28_RS23290	COG1172	Belongs to the binding-protein-dependent transport system permease family
DVS28_RS23295	COG1129	ABC transporter
DVS28_RS23300	COG0673	inositol 2-dehydrogenase activity
DVS28_RS23310	COG1940	carbohydrate kinase activity
DVS28_RS23320	COG0151	Belongs to the GarS family
DVS28_RS23330	COG2072	flavoprotein involved in K transport
DVS28_RS23345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DVS28_RS23355	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DVS28_RS23370	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS23375	COG1082	Xylose isomerase domain protein TIM barrel
DVS28_RS23380	COG0277	FAD linked oxidase domain protein
DVS28_RS23420	COG0123	including yeast histone deacetylase and acetoin utilization protein
DVS28_RS23425	COG0860	N-Acetylmuramoyl-L-alanine amidase
DVS28_RS23425	COG2247	cell wall binding repeat
DVS28_RS23430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DVS28_RS23440	COG0297	glycogen (starch) synthase activity
DVS28_RS23480	COG2200	EAL domain
DVS28_RS23480	COG2202	Pas domain
DVS28_RS23480	COG2199	diguanylate cyclase activity
DVS28_RS23500	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DVS28_RS23505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DVS28_RS23510	COG0363	glucosamine-6-phosphate deaminase activity
DVS28_RS23530	COG0175	sulfate reduction
DVS28_RS23565	COG0745	RESPONSE REGULATOR receiver
DVS28_RS23600	COG0582	viral genome integration into host DNA
DVS28_RS23730	COG0384	phenazine biosynthesis protein PhzF
DVS28_RS23765	COG1191	sigma factor activity
DVS28_RS23770	COG0598	Magnesium transport protein CorA
DVS28_RS23800	COG3583	domain protein
DVS28_RS23810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DVS28_RS23820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DVS28_RS23840	COG1522	sequence-specific DNA binding
DVS28_RS23860	COG4251	negative regulation of phosphorylation
DVS28_RS23865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DVS28_RS23870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DVS28_RS23885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DVS28_RS23890	COG0047	phosphoribosylformylglycinamidine synthase activity
DVS28_RS23905	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DVS28_RS23910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DVS28_RS23915	COG1254	Belongs to the acylphosphatase family
DVS28_RS23920	COG1793	dna ligase
DVS28_RS23920	COG3285	dna ligase
DVS28_RS23935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DVS28_RS23940	COG3604	Transcriptional regulator
DVS28_RS23990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DVS28_RS24000	COG3848	Pyruvate phosphate dikinase
DVS28_RS24000	COG0574	Belongs to the PEP-utilizing enzyme family
DVS28_RS24005	COG0137	argininosuccinate synthase activity
DVS28_RS24035	COG0473	3-isopropylmalate dehydrogenase activity
DVS28_RS24040	COG3842	ATPase activity
DVS28_RS24045	COG3842	ATPase activity
DVS28_RS24055	COG1175	transmembrane transport
DVS28_RS24065	COG0657	acetylesterase activity
DVS28_RS24075	COG0693	protein deglycase activity
DVS28_RS24080	COG2186	Transcriptional regulator
DVS28_RS24085	COG1012	belongs to the aldehyde dehydrogenase family
DVS28_RS24130	COG1611	Belongs to the LOG family
DVS28_RS24135	COG0505	Belongs to the CarA family
DVS28_RS24140	COG0629	single-stranded DNA binding
DVS28_RS24145	COG0360	Binds together with S18 to 16S ribosomal RNA
DVS28_RS24150	COG0629	single-stranded DNA binding
DVS28_RS24155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DVS28_RS24160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DVS28_RS24175	COG0359	binds to the 23S rRNA
DVS28_RS24180	COG1760	l-serine dehydratase
DVS28_RS24185	COG0305	Participates in initiation and elongation during chromosome replication
DVS28_RS24190	COG0778	Nitroreductase
DVS28_RS24190	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DVS28_RS24240	COG1703	isobutyryl-CoA mutase activity
DVS28_RS24240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DVS28_RS24240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DVS28_RS24245	COG1846	Transcriptional regulator
DVS28_RS24285	COG2826	transposase and inactivated derivatives, IS30 family
DVS28_RS24300	COG0714	Associated with various cellular activities
DVS28_RS24325	COG1216	Glycosyl transferase, family 2
DVS28_RS24405	COG4221	oxidoreductase activity
DVS28_RS24420	COG1113	amino acid transport
DVS28_RS24470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DVS28_RS24480	COG0446	pyridine nucleotide-disulphide oxidoreductase
DVS28_RS24480	COG1902	pentaerythritol trinitrate reductase activity
DVS28_RS24495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DVS28_RS24510	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DVS28_RS24530	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS24540	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DVS28_RS24565	COG0584	glycerophosphoryl diester phosphodiesterase
DVS28_RS24580	COG3540	Alkaline phosphatase
DVS28_RS24585	COG0584	glycerophosphoryl diester phosphodiesterase
DVS28_RS24595	COG3540	Alkaline phosphatase
DVS28_RS24600	COG0667	Aldo Keto reductase
DVS28_RS24605	COG0318	PFAM AMP-dependent synthetase and ligase
DVS28_RS24610	COG3268	Saccharopine dehydrogenase
DVS28_RS24615	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS24630	COG2409	Drug exporters of the RND superfamily
DVS28_RS24645	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS24680	COG2119	membrane
DVS28_RS24685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DVS28_RS24690	COG0717	Belongs to the dCTP deaminase family
DVS28_RS24695	COG0596	Alpha beta hydrolase
DVS28_RS24700	COG1522	sequence-specific DNA binding
DVS28_RS24705	COG1501	Belongs to the glycosyl hydrolase 31 family
DVS28_RS24710	COG0247	lactate metabolic process
DVS28_RS24710	COG2181	nitrate reductase activity
DVS28_RS24720	COG2197	response regulator
DVS28_RS24735	COG4149	molybdate abc transporter
DVS28_RS24760	COG0596	Alpha beta hydrolase
DVS28_RS24790	COG0443	Heat shock 70 kDa protein
DVS28_RS24795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DVS28_RS24800	COG0484	heat shock protein binding
DVS28_RS24805	COG0789	Transcriptional regulator
DVS28_RS24845	COG1028	Short-chain dehydrogenase reductase Sdr
DVS28_RS24865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DVS28_RS24870	COG2226	methyltransferase
DVS28_RS24885	COG2010	Cytochrome c
DVS28_RS24890	COG0723	plastoquinol--plastocyanin reductase activity
DVS28_RS24925	COG0438	transferase activity, transferring glycosyl groups
DVS28_RS24935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DVS28_RS24950	COG1260	myo-inositol-1-phosphate synthase
DVS28_RS24970	COG0617	tRNA 3'-terminal CCA addition
DVS28_RS24985	COG0728	peptidoglycan biosynthetic process
DVS28_RS24990	COG2815	serine threonine protein kinase
DVS28_RS24990	COG0515	serine threonine protein kinase
DVS28_RS25005	COG0492	ferredoxin-NADP+ reductase activity
DVS28_RS25015	COG3773	Cell wall hydrolase
DVS28_RS25015	COG3409	Peptidoglycan-binding domain 1 protein
DVS28_RS25025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DVS28_RS25030	COG1181	Belongs to the D-alanine--D-alanine ligase family
DVS28_RS25040	COG1192	Involved in chromosome partitioning
DVS28_RS25050	COG0357	Ribosomal RNA small subunit methyltransferase G
DVS28_RS25065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DVS28_RS25070	COG0594	ribonuclease P activity
DVS28_RS25075	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DVS28_RS25150	COG0328	RNA-DNA hybrid ribonuclease activity
DVS28_RS25305	COG0756	dUTP diphosphatase activity
DVS28_RS25315	COG0629	single-stranded DNA binding
DVS28_RS25630	COG0270	DNA (cytosine-5-)-methyltransferase activity
DVS28_RS25670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DVS28_RS25700	COG1857	crispr-associated protein
DVS28_RS25720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DVS28_RS25755	COG0464	growth
DVS28_RS25855	COG0270	DNA (cytosine-5-)-methyltransferase activity
DVS28_RS25975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DVS28_RS25975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DVS28_RS26010	COG0717	Belongs to the dCTP deaminase family
DVS28_RS26020	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DVS28_RS26160	COG0322	excinuclease ABC activity
DVS28_RS26165	COG1397	ADP-ribosylglycohydrolase
DVS28_RS26170	COG2200	EAL domain
DVS28_RS26170	COG2203	Gaf domain
DVS28_RS26170	COG2199	diguanylate cyclase activity
DVS28_RS26310	COG0745	RESPONSE REGULATOR receiver
DVS28_RS26535	COG0358	DNA primase activity
DVS28_RS26560	COG1793	dna ligase
DVS28_RS26560	COG3285	dna ligase
DVS28_RS26725	COG2018	Roadblock/LC7 domain
DVS28_RS26755	COG0629	single-stranded DNA binding
DVS28_RS26770	COG0419	ATPase involved in DNA repair
DVS28_RS26775	COG0420	3'-5' exonuclease activity
DVS28_RS26785	COG0617	tRNA 3'-terminal CCA addition
DVS28_RS26805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DVS28_RS26805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DVS28_RS26820	COG1335	isochorismatase
DVS28_RS26830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DVS28_RS26835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DVS28_RS26860	COG2255	four-way junction helicase activity
DVS28_RS26980	COG0617	tRNA 3'-terminal CCA addition
DVS28_RS26980	COG1353	crispr-associated protein
DVS28_RS27145	COG4637	Psort location Cytoplasmic, score
DVS28_RS27150	COG0776	regulation of translation
DVS28_RS27290	COG2165	general secretion pathway protein
DVS28_RS27335	COG1459	type II secretion system
DVS28_RS27340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DVS28_RS27450	COG0632	four-way junction helicase activity
DVS28_RS27465	COG0270	DNA (cytosine-5-)-methyltransferase activity
DVS28_RS27530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DVS28_RS27540	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DVS28_RS27640	COG0270	DNA (cytosine-5-)-methyltransferase activity
DVS28_RS27660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DVS28_RS27680	COG1988	membrane-bound metal-dependent
DVS28_RS27785	COG0484	heat shock protein binding
DVS28_RS27800	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DVS28_RS27870	COG0305	Participates in initiation and elongation during chromosome replication
DVS28_RS27870	COG1372	Participates in initiation and elongation during chromosome replication