locus-tag	class	description
HER31_RS00010	COG3437	response regulator, receiver
HER31_RS00025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HER31_RS00030	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HER31_RS00035	COG1757	Na H antiporter
HER31_RS00040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HER31_RS00045	COG0163	prenyltransferase activity
HER31_RS00055	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HER31_RS00060	COG0564	pseudouridine synthase activity
HER31_RS00070	COG0542	response to heat
HER31_RS00100	COG1469	GTP cyclohydrolase I activity
HER31_RS00105	COG5002	protein histidine kinase activity
HER31_RS00105	COG0784	Response regulator, receiver
HER31_RS00105	COG2198	Histidine kinase
HER31_RS00110	COG0745	RESPONSE REGULATOR receiver
HER31_RS00115	COG0527	aspartate kinase activity
HER31_RS00120	COG1522	sequence-specific DNA binding
HER31_RS00125	COG2502	aspartate--ammonia ligase
HER31_RS00130	COG1404	Belongs to the peptidase S8 family
HER31_RS00135	COG0564	pseudouridine synthase activity
HER31_RS00165	COG2130	NADP-dependent
HER31_RS00170	COG1522	sequence-specific DNA binding
HER31_RS00175	COG0531	amino acid
HER31_RS00200	COG2197	response regulator
HER31_RS00230	COG0814	amino acid
HER31_RS00235	COG4990	cell redox homeostasis
HER31_RS00235	COG3591	Belongs to the peptidase S1B family
HER31_RS00245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER31_RS00250	COG3088	subunit of a heme lyase
HER31_RS00250	COG4235	cytochrome complex assembly
HER31_RS00260	COG0484	heat shock protein binding
HER31_RS00270	COG0545	Peptidyl-prolyl cis-trans isomerase
HER31_RS00280	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS00285	COG3301	Polysulphide reductase, NrfD
HER31_RS00290	COG0484	heat shock protein binding
HER31_RS00300	COG0545	Peptidyl-prolyl cis-trans isomerase
HER31_RS00310	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS00315	COG3301	Polysulphide reductase, NrfD
HER31_RS00345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HER31_RS00350	COG0494	nUDIX hydrolase
HER31_RS00360	COG0166	Belongs to the GPI family
HER31_RS00365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HER31_RS00370	COG1115	amino acid carrier protein
HER31_RS00375	COG3022	response to hydroperoxide
HER31_RS00385	COG0268	Binds directly to 16S ribosomal RNA
HER31_RS00390	COG0728	peptidoglycan biosynthetic process
HER31_RS00395	COG0196	riboflavin kinase activity
HER31_RS00400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HER31_RS00405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HER31_RS00410	COG1047	Peptidyl-prolyl cis-trans
HER31_RS00450	COG4968	Prepilin-type N-terminal cleavage methylation domain
HER31_RS00455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HER31_RS00455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HER31_RS00465	COG1131	(ABC) transporter
HER31_RS00470	COG0842	Transport permease protein
HER31_RS00520	COG2813	Specifically methylates the guanine in position
HER31_RS00540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HER31_RS00550	COG3091	SprT-like family
HER31_RS00560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HER31_RS00565	COG1793	dna ligase
HER31_RS00570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HER31_RS00585	COG2050	protein possibly involved in aromatic compounds catabolism
HER31_RS00595	COG4536	flavin adenine dinucleotide binding
HER31_RS00600	COG4137	Cytochrome C assembly protein
HER31_RS00605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HER31_RS00615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HER31_RS00620	COG0336	Belongs to the RNA methyltransferase TrmD family
HER31_RS00625	COG0335	large ribosomal subunit rRNA binding
HER31_RS00630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HER31_RS00635	COG1605	Chorismate mutase
HER31_RS00635	COG0287	Prephenate dehydrogenase
HER31_RS00675	COG4221	oxidoreductase activity
HER31_RS00680	COG0077	Prephenate dehydratase
HER31_RS00680	COG1605	Chorismate mutase
HER31_RS00685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HER31_RS00700	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HER31_RS00720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HER31_RS00725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HER31_RS00730	COG3956	TIGRFAM MazG family protein
HER31_RS00735	COG0504	CTP synthase activity
HER31_RS00745	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HER31_RS00750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HER31_RS00755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HER31_RS00770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HER31_RS00785	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HER31_RS00790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HER31_RS00795	COG2137	regulation of response to DNA damage stimulus
HER31_RS00815	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HER31_RS00820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HER31_RS00825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HER31_RS00830	COG0527	aspartate kinase activity
HER31_RS00835	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HER31_RS00880	COG1238	metal cluster binding
HER31_RS00885	COG0612	Peptidase, M16
HER31_RS00890	COG2918	glutathione biosynthetic process
HER31_RS00895	COG1280	lysine exporter protein (LysE YggA)
HER31_RS00905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HER31_RS00910	COG0142	geranyltranstransferase activity
HER31_RS00915	COG1722	exodeoxyribonuclease VII activity
HER31_RS00920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HER31_RS00930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HER31_RS00930	COG0301	tRNA thio-modification
HER31_RS00940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HER31_RS00945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HER31_RS00970	COG2211	Major facilitator Superfamily
HER31_RS00985	COG2813	Specifically methylates the guanine in position
HER31_RS00995	COG0271	Belongs to the BolA IbaG family
HER31_RS01005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HER31_RS01010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HER31_RS01020	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER31_RS01025	COG1805	sodium ion transport
HER31_RS01030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER31_RS01035	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER31_RS01040	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER31_RS01045	COG2871	sodium ion transport
HER31_RS01050	COG1477	protein flavinylation
HER31_RS01060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HER31_RS01080	COG0450	alkyl hydroperoxide reductase
HER31_RS01095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS01100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HER31_RS01105	COG0745	RESPONSE REGULATOR receiver
HER31_RS01110	COG2205	protein histidine kinase activity
HER31_RS01120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HER31_RS01150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HER31_RS01155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HER31_RS01175	COG4770	biotin carboxylase activity
HER31_RS01180	COG1024	Enoyl-CoA hydratase
HER31_RS01185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HER31_RS01190	COG1960	acyl-CoA dehydrogenase activity
HER31_RS01195	COG0789	Transcriptional regulator
HER31_RS01200	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HER31_RS01210	COG1575	Belongs to the MenA family. Type 1 subfamily
HER31_RS01215	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS01220	COG1946	Acyl-CoA thioesterase
HER31_RS01225	COG1115	amino acid carrier protein
HER31_RS01235	COG4989	oxidoreductase activity
HER31_RS01240	COG3047	cAMP biosynthetic process
HER31_RS01245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HER31_RS01250	COG1309	transcriptional regulator
HER31_RS01265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HER31_RS01270	COG3383	formate dehydrogenase (NAD+) activity
HER31_RS01275	COG0071	Belongs to the small heat shock protein (HSP20) family
HER31_RS01290	COG0513	Belongs to the DEAD box helicase family
HER31_RS01295	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HER31_RS01300	COG3706	GGDEF domain
HER31_RS01320	COG0745	RESPONSE REGULATOR receiver
HER31_RS01330	COG0583	DNA-binding transcription factor activity
HER31_RS01350	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HER31_RS01355	COG0583	DNA-binding transcription factor activity
HER31_RS01365	COG3214	Protein conserved in bacteria
HER31_RS01395	COG0523	cobalamin synthesis protein
HER31_RS01405	COG1595	DNA-templated transcription, initiation
HER31_RS01415	COG4221	oxidoreductase activity
HER31_RS01430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HER31_RS01450	COG0545	Peptidyl-prolyl cis-trans isomerase
HER31_RS01455	COG4681	YaeQ
HER31_RS01465	COG3437	response regulator, receiver
HER31_RS01470	COG4251	negative regulation of phosphorylation
HER31_RS01470	COG5001	Diguanylate cyclase
HER31_RS01470	COG3706	GGDEF domain
HER31_RS01470	COG2203	Gaf domain
HER31_RS01490	COG1595	DNA-templated transcription, initiation
HER31_RS01525	COG0531	amino acid
HER31_RS01535	COG4656	Part of a membrane complex involved in electron transport
HER31_RS01560	COG1454	alcohol dehydrogenase
HER31_RS01575	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HER31_RS01590	COG0280	phosphate acetyltransferase
HER31_RS01595	COG4812	Cobalamin adenosyltransferase
HER31_RS01610	COG4810	utilization protein
HER31_RS01620	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HER31_RS01630	COG1194	a g-specific adenine glycosylase
HER31_RS01665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HER31_RS01670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HER31_RS01690	COG0762	integral membrane protein
HER31_RS01695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HER31_RS01700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HER31_RS01735	COG1566	PFAM secretion protein HlyD family protein
HER31_RS01740	COG0348	domain, Protein
HER31_RS01745	COG3005	denitrification pathway
HER31_RS01755	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HER31_RS01760	COG0583	DNA-binding transcription factor activity
HER31_RS01765	COG0175	sulfate reduction
HER31_RS01775	COG0471	metal ion transport
HER31_RS01775	COG3273	potassium ion transport
HER31_RS01780	COG0529	Catalyzes the synthesis of activated sulfate
HER31_RS01790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HER31_RS01795	COG1940	carbohydrate kinase activity
HER31_RS01810	COG1555	photosystem II stabilization
HER31_RS01870	COG3328	transposase activity
HER31_RS01935	COG0484	heat shock protein binding
HER31_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS02045	COG1518	maintenance of DNA repeat elements
HER31_RS02070	COG0243	molybdopterin cofactor binding
HER31_RS02075	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS02080	COG3381	protein complex oligomerization
HER31_RS02100	COG1309	transcriptional regulator
HER31_RS02130	COG0583	DNA-binding transcription factor activity
HER31_RS02135	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS02150	COG2321	neutral zinc metallopeptidase
HER31_RS02160	COG0625	glutathione transferase activity
HER31_RS02165	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS02185	COG0625	glutathione transferase activity
HER31_RS02205	COG0583	DNA-binding transcription factor activity
HER31_RS02215	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HER31_RS02225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HER31_RS02240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HER31_RS02245	COG4172	Belongs to the ABC transporter superfamily
HER31_RS02255	COG4171	peptide transport system, permease
HER31_RS02265	COG0747	negative chemotaxis
HER31_RS02270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HER31_RS02275	COG1842	Phage shock protein A
HER31_RS02285	COG1983	PspC domain protein
HER31_RS02290	COG3106	COG3106 Predicted ATPase
HER31_RS02295	COG3768	UPF0283 membrane protein
HER31_RS02300	COG0626	cystathionine gamma-synthase activity
HER31_RS02310	COG2154	pterin-4-alpha-carbinolamine dehydratase
HER31_RS02330	COG0625	glutathione transferase activity
HER31_RS02465	COG2755	lipolytic protein G-D-S-L family
HER31_RS02470	COG4181	ATPase activity
HER31_RS02475	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HER31_RS02480	COG1090	epimerase
HER31_RS02485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HER31_RS02490	COG0628	permease
HER31_RS02495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HER31_RS02505	COG0405	Gamma-glutamyltransferase
HER31_RS02530	COG0617	tRNA 3'-terminal CCA addition
HER31_RS02530	COG0517	IMP dehydrogenase activity
HER31_RS02530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HER31_RS02535	COG0857	belongs to the CobB CobQ family
HER31_RS02535	COG0280	phosphate acetyltransferase
HER31_RS02540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HER31_RS02550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HER31_RS02555	COG1882	Formate acetyltransferase
HER31_RS02570	COG4145	pantothenate transmembrane transporter activity
HER31_RS02580	COG0708	Exodeoxyribonuclease III
HER31_RS02585	COG2350	Protein conserved in bacteria
HER31_RS02590	COG2223	nitrite transmembrane transporter activity
HER31_RS02595	COG2917	probably involved in intracellular septation
HER31_RS02600	COG0159	tryptophan synthase activity
HER31_RS02605	COG0133	tryptophan synthase activity
HER31_RS02610	COG0135	phosphoribosylanthranilate isomerase activity
HER31_RS02610	COG0134	indole-3-glycerol-phosphate synthase activity
HER31_RS02620	COG0512	Glutamine amidotransferase of anthranilate synthase
HER31_RS02625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HER31_RS02630	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HER31_RS02635	COG0613	PHP domain protein
HER31_RS02640	COG0009	L-threonylcarbamoyladenylate synthase
HER31_RS02645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HER31_RS02650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HER31_RS02660	COG4628	conserved protein (DUF2132)
HER31_RS02665	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS02675	COG0616	signal peptide processing
HER31_RS02680	COG1301	dicarboxylic acid transport
HER31_RS02685	COG3724	N-succinylarginine dihydrolase activity
HER31_RS02700	COG0583	DNA-binding transcription factor activity
HER31_RS02705	COG1760	l-serine dehydratase
HER31_RS02720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HER31_RS02730	COG3220	belongs to the UPF0276 family
HER31_RS02740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HER31_RS02745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HER31_RS02755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HER31_RS02760	COG0210	DNA helicase
HER31_RS02770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HER31_RS02775	COG2867	negative regulation of translational initiation
HER31_RS02780	COG2914	Belongs to the UPF0125 (RnfH) family
HER31_RS02785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HER31_RS02790	COG1454	alcohol dehydrogenase
HER31_RS02795	COG0497	DNA recombination
HER31_RS02800	COG0300	oxidoreductase activity
HER31_RS02810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HER31_RS02820	COG4221	oxidoreductase activity
HER31_RS02825	COG0583	DNA-binding transcription factor activity
HER31_RS02835	COG0443	Heat shock 70 kDa protein
HER31_RS02840	COG0484	heat shock protein binding
HER31_RS02850	COG0823	Involved in the tonB-independent uptake of proteins
HER31_RS02850	COG1506	peptidase
HER31_RS02850	COG4946	Tricorn protease homolog
HER31_RS02855	COG0501	Belongs to the peptidase M48B family
HER31_RS02860	COG0545	Peptidyl-prolyl cis-trans isomerase
HER31_RS02865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HER31_RS02870	COG0505	Belongs to the CarA family
HER31_RS02875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HER31_RS02890	COG1534	Rna-binding protein
HER31_RS02895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HER31_RS02900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HER31_RS02905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HER31_RS02910	COG0149	triose-phosphate isomerase activity
HER31_RS02915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HER31_RS02935	COG0195	Participates in both transcription termination and antitermination
HER31_RS02940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HER31_RS02950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HER31_RS02955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HER31_RS02960	COG1185	polyribonucleotide nucleotidyltransferase activity
HER31_RS02980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HER31_RS02985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HER31_RS02995	COG0084	hydrolase, TatD family'
HER31_RS03000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HER31_RS03010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HER31_RS03015	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HER31_RS03020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HER31_RS03025	COG0813	purine-nucleoside phosphorylase activity
HER31_RS03035	COG0560	Phosphoserine phosphatase
HER31_RS03045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HER31_RS03060	COG3850	Histidine kinase
HER31_RS03060	COG2205	protein histidine kinase activity
HER31_RS03060	COG4999	Histidine kinase
HER31_RS03060	COG3437	response regulator, receiver
HER31_RS03075	COG0318	PFAM AMP-dependent synthetase and ligase
HER31_RS03110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HER31_RS03115	COG4535	Mg2 and Co2 transporter CorC
HER31_RS03120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HER31_RS03125	COG1702	phosphate starvation-inducible protein PhoH
HER31_RS03130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HER31_RS03135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HER31_RS03150	COG0500	methyltransferase
HER31_RS03155	COG5002	protein histidine kinase activity
HER31_RS03160	COG0745	RESPONSE REGULATOR receiver
HER31_RS03170	COG0463	Glycosyl transferase, family 2
HER31_RS03175	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HER31_RS03190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HER31_RS03195	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HER31_RS03200	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HER31_RS03215	COG1254	Belongs to the acylphosphatase family
HER31_RS03225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HER31_RS03235	COG4591	ABC-type transport system involved in lipoprotein release permease component
HER31_RS03240	COG1136	(ABC) transporter
HER31_RS03245	COG4591	ABC-type transport system involved in lipoprotein release permease component
HER31_RS03250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HER31_RS03265	COG0658	competence protein
HER31_RS03265	COG2333	competence protein COMEC
HER31_RS03275	COG1663	tetraacyldisaccharide 4'-kinase activity
HER31_RS03280	COG2835	tetraacyldisaccharide 4'-kinase activity
HER31_RS03285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HER31_RS03295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HER31_RS03315	COG0372	Belongs to the citrate synthase family
HER31_RS03325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HER31_RS03340	COG0567	Dehydrogenase, E1 component
HER31_RS03345	COG0508	dehydrogenase complex catalyzes the overall conversion of
HER31_RS03350	COG0045	succinate-CoA ligase (ADP-forming) activity
HER31_RS03365	COG0840	transmembrane signaling receptor activity
HER31_RS03380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HER31_RS03400	COG0653	protein targeting
HER31_RS03405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HER31_RS03415	COG1929	Belongs to the glycerate kinase type-1 family
HER31_RS03450	COG3005	denitrification pathway
HER31_RS03460	COG2072	flavoprotein involved in K transport
HER31_RS03465	COG0735	belongs to the Fur family
HER31_RS03470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HER31_RS03475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HER31_RS03475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HER31_RS03480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HER31_RS03495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HER31_RS03505	COG0501	Belongs to the peptidase M48B family
HER31_RS03510	COG1053	succinate dehydrogenase
HER31_RS03515	COG1053	succinate dehydrogenase
HER31_RS03520	COG0602	queuosine metabolic process
HER31_RS03525	COG0720	synthase
HER31_RS03535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HER31_RS03535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HER31_RS03540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HER31_RS03545	COG2814	Major facilitator Superfamily
HER31_RS03550	COG0583	DNA-binding transcription factor activity
HER31_RS03555	COG1530	ribonuclease E activity
HER31_RS03560	COG0564	pseudouridine synthase activity
HER31_RS03565	COG0546	phosphoglycolate phosphatase activity
HER31_RS03575	COG0424	maF-like protein
HER31_RS03580	COG1399	metal-binding, possibly nucleic acid-binding protein
HER31_RS03585	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HER31_RS03595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HER31_RS03600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HER31_RS03605	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS03610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HER31_RS03615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HER31_RS03620	COG2084	Dehydrogenase
HER31_RS03625	COG0295	cytidine deaminase activity
HER31_RS03630	COG2925	Exonuclease
HER31_RS03650	COG0714	Associated with various cellular activities
HER31_RS03655	COG0741	lytic transglycosylase activity
HER31_RS03660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HER31_RS03695	COG1342	Belongs to the UPF0251 family
HER31_RS03705	COG1960	acyl-CoA dehydrogenase activity
HER31_RS03710	COG2991	Protein conserved in bacteria
HER31_RS03720	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER31_RS03725	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HER31_RS03735	COG1805	sodium ion transport
HER31_RS03745	COG4221	oxidoreductase activity
HER31_RS03775	COG1215	transferase activity, transferring glycosyl groups
HER31_RS03780	COG0366	Alpha amylase catalytic
HER31_RS03800	COG0729	surface antigen
HER31_RS03805	COG1446	asparaginase
HER31_RS03845	COG0583	DNA-binding transcription factor activity
HER31_RS03855	COG2824	Alkylphosphonate utilization operon protein PhnA
HER31_RS03860	COG0488	(ABC) transporter
HER31_RS03865	COG2195	Cleaves the N-terminal amino acid of tripeptides
HER31_RS03880	COG3268	Saccharopine dehydrogenase
HER31_RS03885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HER31_RS03935	COG3021	interspecies interaction between organisms
HER31_RS03940	COG3590	peptidase
HER31_RS03950	COG0697	spore germination
HER31_RS03960	COG0259	pyridoxamine-phosphate oxidase activity
HER31_RS03965	COG3706	GGDEF domain
HER31_RS03970	COG0288	reversible hydration of carbon dioxide
HER31_RS03985	COG0537	adenosine 5'-monophosphoramidase activity
HER31_RS04010	COG4774	siderophore transport
HER31_RS04020	COG3201	nicotinamide mononucleotide transporter
HER31_RS04045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HER31_RS04050	COG0778	Nitroreductase
HER31_RS04070	COG2855	membrane
HER31_RS04085	COG0573	inorganic phosphate transmembrane transporter activity
HER31_RS04090	COG0581	inorganic phosphate transmembrane transporter activity
HER31_RS04095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HER31_RS04105	COG2095	MarC family integral membrane protein
HER31_RS04130	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HER31_RS04135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HER31_RS04140	COG0436	Aminotransferase
HER31_RS04150	COG0716	FMN binding
HER31_RS04165	COG0596	Alpha beta hydrolase
HER31_RS04170	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HER31_RS04175	COG0033	Phosphoglucomutase
HER31_RS04180	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HER31_RS04185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HER31_RS04190	COG2988	succinylglutamate desuccinylase activity
HER31_RS04200	COG0022	dehydrogenase e1 component
HER31_RS04210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HER31_RS04225	COG0443	Heat shock 70 kDa protein
HER31_RS04250	COG3083	sulfuric ester hydrolase activity
HER31_RS04260	COG3081	Nucleoid-associated protein
HER31_RS04270	COG0393	Putative heavy-metal-binding
HER31_RS04275	COG0393	Putative heavy-metal-binding
HER31_RS04300	COG0121	glutamine amidotransferase
HER31_RS04330	COG0587	DNA-directed DNA polymerase activity
HER31_RS04340	COG5001	Diguanylate cyclase
HER31_RS04340	COG3300	MHYT domain
HER31_RS04350	COG1846	Transcriptional regulator
HER31_RS04360	COG0754	glutathionylspermidine amidase activity
HER31_RS04365	COG5463	Belongs to the UPF0441 family
HER31_RS04405	COG2207	Transcriptional regulator
HER31_RS04425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HER31_RS04430	COG4660	Part of a membrane complex involved in electron transport
HER31_RS04440	COG4658	electron transport chain
HER31_RS04450	COG2878	Part of a membrane complex involved in electron transport
HER31_RS04455	COG4657	Part of a membrane complex involved in electron transport
HER31_RS04460	COG2200	EAL domain
HER31_RS04475	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HER31_RS04480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HER31_RS04490	COG0848	biopolymer transport protein
HER31_RS04495	COG0811	peptide transport
HER31_RS04510	COG3721	Heme iron utilization protein
HER31_RS04515	COG0748	coenzyme F420 binding
HER31_RS04520	COG1132	(ABC) transporter
HER31_RS04580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HER31_RS04585	COG0651	ATP synthesis coupled electron transport
HER31_RS04590	COG0650	Formate hydrogenlyase subunit 4
HER31_RS04595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HER31_RS04600	COG4237	Hydrogenase 4 membrane
HER31_RS04605	COG0651	ATP synthesis coupled electron transport
HER31_RS04610	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HER31_RS04610	COG3261	NADH dehydrogenase
HER31_RS04615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HER31_RS04620	COG3260	NADH ubiquinone oxidoreductase 20
HER31_RS04630	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HER31_RS04635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HER31_RS04645	COG3604	Transcriptional regulator
HER31_RS04655	COG2116	formate transmembrane transporter activity
HER31_RS04665	COG1921	L-seryl-tRNASec selenium transferase activity
HER31_RS04765	COG4206	TonB-dependent receptor
HER31_RS04770	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HER31_RS04775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HER31_RS04785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HER31_RS04805	COG1492	cobalamin metabolic process
HER31_RS04815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HER31_RS04820	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HER31_RS04825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HER31_RS04840	COG1811	Na channel or pump
HER31_RS04870	COG0583	DNA-binding transcription factor activity
HER31_RS04880	COG1053	succinate dehydrogenase
HER31_RS04935	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS04940	COG0243	molybdopterin cofactor binding
HER31_RS04950	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS04955	COG0243	molybdopterin cofactor binding
HER31_RS04975	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS04980	COG0243	molybdopterin cofactor binding
HER31_RS05000	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HER31_RS05045	COG4822	anaerobic cobalamin biosynthetic process
HER31_RS05060	COG1648	precorrin-2 dehydrogenase activity
HER31_RS05060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HER31_RS05065	COG0601	transmembrane transport
HER31_RS05075	COG0747	negative chemotaxis
HER31_RS05080	COG0444	Belongs to the ABC transporter superfamily
HER31_RS05090	COG0534	Mate efflux family protein
HER31_RS05170	COG0556	nucleotide-excision repair
HER31_RS05185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HER31_RS05195	COG3530	Putative quorum-sensing-regulated virulence factor
HER31_RS05255	COG2197	response regulator
HER31_RS05260	COG0322	excinuclease ABC activity
HER31_RS05320	COG2816	NAD+ diphosphatase activity
HER31_RS05325	COG2827	Endonuclease containing a URI domain
HER31_RS05330	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HER31_RS05345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS05350	COG1309	transcriptional regulator
HER31_RS05355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HER31_RS05370	COG1505	serine-type exopeptidase activity
HER31_RS05375	COG0824	Thioesterase
HER31_RS05380	COG0811	peptide transport
HER31_RS05395	COG0823	Involved in the tonB-independent uptake of proteins
HER31_RS05400	COG2885	chlorophyll binding
HER31_RS05405	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HER31_RS05475	COG1216	Glycosyl transferase, family 2
HER31_RS05480	COG2204	response regulator
HER31_RS05485	COG4191	Histidine kinase
HER31_RS05525	COG1215	transferase activity, transferring glycosyl groups
HER31_RS05545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HER31_RS05550	COG1061	Type III restriction enzyme res subunit
HER31_RS05555	COG2056	Na+-H+ antiporter family
HER31_RS05560	COG0450	alkyl hydroperoxide reductase
HER31_RS05575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HER31_RS05585	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HER31_RS05595	COG0622	Phosphoesterase
HER31_RS05605	COG1278	Cold shock
HER31_RS05610	COG1278	Cold shock
HER31_RS05615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HER31_RS05620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HER31_RS05645	COG0739	heme binding
HER31_RS05655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HER31_RS05660	COG0784	Response regulator, receiver
HER31_RS05660	COG2198	Histidine kinase
HER31_RS05660	COG2205	protein histidine kinase activity
HER31_RS05710	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HER31_RS05730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HER31_RS05735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HER31_RS05740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HER31_RS05740	COG0574	Belongs to the PEP-utilizing enzyme family
HER31_RS05745	COG0247	lactate metabolic process
HER31_RS05745	COG0277	FAD linked oxidase domain protein
HER31_RS05755	COG0583	DNA-binding transcription factor activity
HER31_RS05770	COG0281	malic enzyme
HER31_RS05790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HER31_RS05825	COG0475	glutathione-regulated potassium exporter activity
HER31_RS05825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HER31_RS05830	COG2249	NAD(P)H dehydrogenase (quinone) activity
HER31_RS05840	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HER31_RS05845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HER31_RS05850	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HER31_RS05855	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HER31_RS05860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HER31_RS05865	COG0298	carbon dioxide binding
HER31_RS05870	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HER31_RS05880	COG0375	protein maturation
HER31_RS05885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HER31_RS05895	COG0405	Gamma-glutamyltransferase
HER31_RS05900	COG1115	amino acid carrier protein
HER31_RS05910	COG0583	DNA-binding transcription factor activity
HER31_RS05915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HER31_RS05930	COG0189	ligase activity
HER31_RS05930	COG4067	protein conserved in archaea
HER31_RS05935	COG0500	methyltransferase
HER31_RS05940	COG2226	methyltransferase
HER31_RS05965	COG2255	four-way junction helicase activity
HER31_RS05990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HER31_RS06000	COG3383	formate dehydrogenase (NAD+) activity
HER31_RS06005	COG1388	LysM domain
HER31_RS06005	COG1376	ErfK ybiS ycfS ynhG family protein
HER31_RS06015	COG1272	protein, Hemolysin III
HER31_RS06025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HER31_RS06030	COG1785	Belongs to the alkaline phosphatase family
HER31_RS06035	COG1328	CTP reductase activity
HER31_RS06040	COG0602	queuosine metabolic process
HER31_RS06090	COG2814	Major facilitator Superfamily
HER31_RS06115	COG0745	RESPONSE REGULATOR receiver
HER31_RS06130	COG3043	anaerobic respiration
HER31_RS06135	COG0243	molybdopterin cofactor binding
HER31_RS06165	COG0670	Belongs to the BI1 family
HER31_RS06180	COG0573	inorganic phosphate transmembrane transporter activity
HER31_RS06185	COG0581	inorganic phosphate transmembrane transporter activity
HER31_RS06190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HER31_RS06195	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HER31_RS06200	COG0513	Belongs to the DEAD box helicase family
HER31_RS06215	COG4206	TonB-dependent receptor
HER31_RS06220	COG1120	ATPase activity
HER31_RS06225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HER31_RS06230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HER31_RS06235	COG5265	(ABC) transporter
HER31_RS06245	COG1227	inorganic diphosphatase activity
HER31_RS06255	COG2815	serine threonine protein kinase
HER31_RS06255	COG0515	serine threonine protein kinase
HER31_RS06285	COG3706	GGDEF domain
HER31_RS06320	COG0583	DNA-binding transcription factor activity
HER31_RS06325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HER31_RS06330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HER31_RS06350	COG0534	Mate efflux family protein
HER31_RS06355	COG0307	riboflavin synthase, alpha
HER31_RS06370	COG3001	Fructosamine kinase
HER31_RS06375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HER31_RS06380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HER31_RS06385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HER31_RS06390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HER31_RS06405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HER31_RS06410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HER31_RS06420	COG0519	Catalyzes the synthesis of GMP from XMP
HER31_RS06440	COG3263	regulation of cellular component size
HER31_RS06480	COG0714	Associated with various cellular activities
HER31_RS06485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HER31_RS06485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HER31_RS06490	COG0489	protein tyrosine kinase activity
HER31_RS06495	COG0572	uridine kinase
HER31_RS06510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HER31_RS06515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HER31_RS06520	COG0470	DNA polymerase III
HER31_RS06530	COG0084	hydrolase, TatD family'
HER31_RS06535	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HER31_RS06535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HER31_RS06540	COG2715	membrane protein required for spore maturation
HER31_RS06545	COG3008	intermembrane lipid transfer
HER31_RS06550	COG2995	paraquat-inducible protein a
HER31_RS06555	COG2995	paraquat-inducible protein a
HER31_RS06560	COG1956	GAF domain-containing protein
HER31_RS06570	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HER31_RS06575	COG0793	Belongs to the peptidase S41A family
HER31_RS06580	COG0733	neurotransmitter:sodium symporter activity
HER31_RS06585	COG0308	aminopeptidase N
HER31_RS06610	COG2409	Drug exporters of the RND superfamily
HER31_RS06620	COG0167	dihydroorotate dehydrogenase activity
HER31_RS06650	COG3130	regulation of translation
HER31_RS06655	COG0386	Belongs to the glutathione peroxidase family
HER31_RS06660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HER31_RS06665	COG1067	ATP-dependent peptidase activity
HER31_RS06695	COG1511	domain protein
HER31_RS06695	COG3264	Mechanosensitive ion channel
HER31_RS06705	COG3278	Belongs to the heme-copper respiratory oxidase family
HER31_RS06730	COG2217	Heavy metal translocating P-type atpase
HER31_RS06745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HER31_RS06750	COG0589	response to stress
HER31_RS06755	COG0037	tRNA processing
HER31_RS06780	COG1177	transmembrane transport
HER31_RS06790	COG1448	Aminotransferase
HER31_RS06815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HER31_RS06820	COG2027	D-alanyl-D-alanine carboxypeptidase
HER31_RS06830	COG1960	acyl-CoA dehydrogenase activity
HER31_RS06835	COG0284	orotidine-5'-phosphate decarboxylase activity
HER31_RS06840	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HER31_RS06850	COG0776	regulation of translation
HER31_RS06855	COG0539	negative regulation of cytoplasmic translation
HER31_RS06860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HER31_RS06865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HER31_RS06870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HER31_RS06875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HER31_RS06885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HER31_RS06895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HER31_RS06905	COG0633	Ferredoxin
HER31_RS06920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HER31_RS06920	COG1902	pentaerythritol trinitrate reductase activity
HER31_RS06925	COG0616	signal peptide processing
HER31_RS06930	COG0252	asparaginase activity
HER31_RS06935	COG3139	Protein of unknown function (DUF1315)
HER31_RS06955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HER31_RS07000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS07025	COG0800	Aldolase
HER31_RS07030	COG0129	dihydroxy-acid dehydratase activity
HER31_RS07035	COG0363	glucosamine-6-phosphate deaminase activity
HER31_RS07040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HER31_RS07045	COG1737	Transcriptional regulator
HER31_RS07050	COG0469	pyruvate kinase activity
HER31_RS07060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HER31_RS07065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HER31_RS07075	COG1674	ftsk spoiiie
HER31_RS07075	COG0531	amino acid
HER31_RS07085	COG0686	Belongs to the AlaDH PNT family
HER31_RS07090	COG0492	ferredoxin-NADP+ reductase activity
HER31_RS07095	COG4988	ABC transporter
HER31_RS07100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HER31_RS07110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HER31_RS07115	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HER31_RS07120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HER31_RS07125	COG0864	Transcriptional regulator
HER31_RS07130	COG0747	negative chemotaxis
HER31_RS07140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HER31_RS07145	COG4172	Belongs to the ABC transporter superfamily
HER31_RS07150	COG0542	response to heat
HER31_RS07155	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HER31_RS07160	COG1278	Cold shock
HER31_RS07165	COG0538	isocitrate dehydrogenase activity
HER31_RS07175	COG0482	sulfurtransferase activity
HER31_RS07180	COG2915	High frequency lysogenization protein hflD homolog
HER31_RS07185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HER31_RS07190	COG2850	peptidyl-arginine hydroxylation
HER31_RS07215	COG0346	lactoylglutathione lyase activity
HER31_RS07240	COG0564	pseudouridine synthase activity
HER31_RS07255	COG0848	biopolymer transport protein
HER31_RS07260	COG0811	peptide transport
HER31_RS07265	COG0811	peptide transport
HER31_RS07275	COG1228	amidohydrolase
HER31_RS07290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HER31_RS07310	COG0840	transmembrane signaling receptor activity
HER31_RS07320	COG1643	Atp-dependent helicase
HER31_RS07325	COG0302	gtp cyclohydrolase
HER31_RS07335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HER31_RS07345	COG3341	Caulimovirus viroplasmin
HER31_RS07345	COG0328	RNA-DNA hybrid ribonuclease activity
HER31_RS07350	COG1012	belongs to the aldehyde dehydrogenase family
HER31_RS07350	COG1454	alcohol dehydrogenase
HER31_RS07355	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS07360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HER31_RS07365	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HER31_RS07420	COG3647	Membrane
HER31_RS07430	COG1132	(ABC) transporter
HER31_RS07435	COG1132	(ABC) transporter
HER31_RS07450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER31_RS07475	COG1477	protein flavinylation
HER31_RS07500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HER31_RS07510	COG2766	serine protein kinase
HER31_RS07515	COG2718	Belongs to the UPF0229 family
HER31_RS07520	COG2719	SpoVR family
HER31_RS07535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HER31_RS07540	COG2983	Belongs to the UPF0260 family
HER31_RS07545	COG2951	lytic endotransglycosylase activity
HER31_RS07550	COG3100	YcgL domain-containing protein
HER31_RS07560	COG2894	cell division
HER31_RS07565	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HER31_RS07575	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HER31_RS07580	COG0318	PFAM AMP-dependent synthetase and ligase
HER31_RS07605	COG1199	ATP-dependent helicase activity
HER31_RS07615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HER31_RS07620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HER31_RS07625	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HER31_RS07625	COG0131	Imidazoleglycerol-phosphate dehydratase
HER31_RS07630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HER31_RS07635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HER31_RS07645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HER31_RS07645	COG0140	phosphoribosyl-ATP diphosphatase activity
HER31_RS07655	COG0776	regulation of translation
HER31_RS07660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HER31_RS07660	COG0072	phenylalanine-tRNA ligase activity
HER31_RS07665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HER31_RS07670	COG0840	transmembrane signaling receptor activity
HER31_RS07690	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HER31_RS07710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HER31_RS07715	COG0583	DNA-binding transcription factor activity
HER31_RS07725	COG1132	(ABC) transporter
HER31_RS07735	COG3141	response to X-ray
HER31_RS07745	COG0745	RESPONSE REGULATOR receiver
HER31_RS07770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HER31_RS07775	COG1256	bacterial-type flagellum assembly
HER31_RS07785	COG1706	bacterial-type flagellum-dependent cell motility
HER31_RS07790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HER31_RS07795	COG4786	Flagellar basal body rod
HER31_RS07800	COG4787	bacterial-type flagellum-dependent cell motility
HER31_RS07805	COG1749	Flagellar hook protein flgE
HER31_RS07820	COG1815	bacterial-type flagellum-dependent cell motility
HER31_RS07830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HER31_RS07840	COG1360	Flagellar Motor Protein
HER31_RS07845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HER31_RS07850	COG1191	sigma factor activity
HER31_RS07870	COG1516	flagellar protein fliS
HER31_RS07875	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HER31_RS07880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HER31_RS07910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HER31_RS07920	COG1677	Flagellar hook-basal body complex protein FliE
HER31_RS07960	COG1987	bacterial-type flagellum assembly
HER31_RS07965	COG1684	flagellar biosynthetic protein fliR
HER31_RS08000	COG5499	transcription regulator containing HTH domain
HER31_RS08055	COG0328	RNA-DNA hybrid ribonuclease activity
HER31_RS08060	COG2226	methyltransferase
HER31_RS08065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HER31_RS08070	COG0741	lytic transglycosylase activity
HER31_RS08070	COG1388	LysM domain
HER31_RS08075	COG1668	transmembrane transport
HER31_RS08080	COG4555	ABC transporter
HER31_RS08100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HER31_RS08110	COG0415	Belongs to the DNA photolyase family
HER31_RS08170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HER31_RS08175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HER31_RS08180	COG2011	ABC-type metal ion transport system permease component
HER31_RS08185	COG1464	Belongs to the NlpA lipoprotein family
HER31_RS08190	COG1704	LemA family
HER31_RS08195	COG0501	Belongs to the peptidase M48B family
HER31_RS08200	COG0676	glucose-6-phosphate 1-epimerase activity
HER31_RS08225	COG5002	protein histidine kinase activity
HER31_RS08225	COG2176	DNA-directed DNA polymerase activity
HER31_RS08230	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HER31_RS08230	COG0517	IMP dehydrogenase activity
HER31_RS08250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HER31_RS08270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HER31_RS08275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HER31_RS08280	COG3115	cell septum assembly
HER31_RS08285	COG1196	nuclear chromosome segregation
HER31_RS08290	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HER31_RS08305	COG0596	Alpha beta hydrolase
HER31_RS08325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HER31_RS08340	COG1393	Belongs to the ArsC family
HER31_RS08345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HER31_RS08350	COG1876	peptidase activity
HER31_RS08355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HER31_RS08370	COG2988	succinylglutamate desuccinylase activity
HER31_RS08390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HER31_RS08395	COG1074	ATP-dependent DNA helicase activity
HER31_RS08400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HER31_RS08405	COG3104	oligopeptide transport
HER31_RS08415	COG0583	DNA-binding transcription factor activity
HER31_RS08440	COG0243	molybdopterin cofactor binding
HER31_RS08450	COG3005	denitrification pathway
HER31_RS08475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HER31_RS08485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HER31_RS08495	COG2716	regulation of RNA biosynthetic process
HER31_RS08500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HER31_RS08520	COG4783	chaperone-mediated protein folding
HER31_RS08545	COG1309	transcriptional regulator
HER31_RS08555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HER31_RS08575	COG0583	DNA-binding transcription factor activity
HER31_RS08600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HER31_RS08605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HER31_RS08610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HER31_RS08615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HER31_RS08620	COG4953	penicillin-binding protein 1C
HER31_RS08625	COG0778	Nitroreductase
HER31_RS08625	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HER31_RS08630	COG2195	Cleaves the N-terminal amino acid of tripeptides
HER31_RS08635	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HER31_RS08645	COG0647	UMP catabolic process
HER31_RS08660	COG0367	asparagine synthase
HER31_RS08665	COG2873	o-acetylhomoserine
HER31_RS08675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HER31_RS08680	COG1349	DNA-binding transcription factor activity
HER31_RS08685	COG4206	TonB-dependent receptor
HER31_RS08690	COG2226	methyltransferase
HER31_RS08715	COG0540	Belongs to the ATCase OTCase family
HER31_RS08720	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HER31_RS08725	COG2315	Protein conserved in bacteria
HER31_RS08730	COG0604	alcohol dehydrogenase
HER31_RS08740	COG1024	Enoyl-CoA hydratase
HER31_RS08740	COG1250	3-hydroxyacyl-CoA dehydrogenase
HER31_RS08745	COG1960	acyl-CoA dehydrogenase activity
HER31_RS08750	COG1917	Cupin 2, conserved barrel domain protein
HER31_RS08750	COG2169	Transcriptional regulator
HER31_RS08760	COG2414	aldehyde ferredoxin oxidoreductase
HER31_RS08820	COG4566	intracellular signal transduction
HER31_RS08830	COG1477	protein flavinylation
HER31_RS08835	COG3976	FMN-binding domain protein
HER31_RS08835	COG1053	succinate dehydrogenase
HER31_RS08835	COG0431	NADPH-dependent FMN reductase
HER31_RS08850	COG2119	membrane
HER31_RS08855	COG0277	FAD linked oxidase domain protein
HER31_RS08860	COG1620	l-lactate permease
HER31_RS08865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HER31_RS08865	COG0519	Catalyzes the synthesis of GMP from XMP
HER31_RS08870	COG0516	GMP reductase activity
HER31_RS08870	COG0517	IMP dehydrogenase activity
HER31_RS08880	COG3706	GGDEF domain
HER31_RS08885	COG1160	GTP binding
HER31_RS08890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HER31_RS08895	COG2976	Protein conserved in bacteria
HER31_RS08900	COG0124	histidyl-tRNA synthetase
HER31_RS08905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HER31_RS08910	COG1426	Protein conserved in bacteria
HER31_RS08920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HER31_RS08925	COG1253	flavin adenine dinucleotide binding
HER31_RS08930	COG0105	UTP biosynthetic process
HER31_RS08945	COG0633	Ferredoxin
HER31_RS08950	COG0443	Heat shock 70 kDa protein
HER31_RS08960	COG0316	Belongs to the HesB IscA family
HER31_RS08965	COG0822	iron-sulfur transferase activity
HER31_RS08970	COG1104	cysteine desulfurase activity
HER31_RS08975	COG1959	2 iron, 2 sulfur cluster binding
HER31_RS09005	COG3275	phosphorelay sensor kinase activity
HER31_RS09010	COG3279	Response regulator of the LytR AlgR family
HER31_RS09015	COG0776	regulation of translation
HER31_RS09020	COG1966	Carbon starvation protein
HER31_RS09030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HER31_RS09030	COG1648	precorrin-2 dehydrogenase activity
HER31_RS09040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HER31_RS09045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HER31_RS09050	COG1862	Preprotein translocase
HER31_RS09060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HER31_RS09080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HER31_RS09100	COG0745	RESPONSE REGULATOR receiver
HER31_RS09105	COG5002	protein histidine kinase activity
HER31_RS09110	COG0704	Plays a role in the regulation of phosphate uptake
HER31_RS09115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HER31_RS09120	COG0581	inorganic phosphate transmembrane transporter activity
HER31_RS09130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HER31_RS09135	COG0248	Ppx GppA phosphatase
HER31_RS09145	COG5002	protein histidine kinase activity
HER31_RS09150	COG0745	RESPONSE REGULATOR receiver
HER31_RS09160	COG2974	May be involved in recombination
HER31_RS09170	COG3706	GGDEF domain
HER31_RS09175	COG1611	Belongs to the LOG family
HER31_RS09180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HER31_RS09215	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HER31_RS09225	COG1506	peptidase
HER31_RS09225	COG4946	Tricorn protease homolog
HER31_RS09225	COG0823	Involved in the tonB-independent uptake of proteins
HER31_RS09230	COG0473	3-isopropylmalate dehydrogenase activity
HER31_RS09250	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HER31_RS09255	COG2363	Small membrane protein
HER31_RS09265	COG0583	DNA-binding transcription factor activity
HER31_RS09275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS09280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HER31_RS09315	COG0750	zinc metalloprotease
HER31_RS09320	COG0653	protein targeting
HER31_RS09360	COG1121	(ABC) transporter
HER31_RS09365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HER31_RS09380	COG3321	synthase
HER31_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS09380	COG0604	alcohol dehydrogenase
HER31_RS09420	COG2890	protein-(glutamine-N5) methyltransferase activity
HER31_RS09425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HER31_RS09430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HER31_RS09440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HER31_RS09450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HER31_RS09455	COG0737	Belongs to the 5'-nucleotidase family
HER31_RS09460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HER31_RS09465	COG0193	aminoacyl-tRNA hydrolase activity
HER31_RS09470	COG0012	GTP binding
HER31_RS09540	COG1309	transcriptional regulator
HER31_RS09550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HER31_RS09560	COG1294	oxidase, subunit
HER31_RS09575	COG2866	Carboxypeptidase
HER31_RS09605	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HER31_RS09615	COG3706	GGDEF domain
HER31_RS09615	COG4251	negative regulation of phosphorylation
HER31_RS09615	COG5001	Diguanylate cyclase
HER31_RS09615	COG2203	Gaf domain
HER31_RS09625	COG3220	belongs to the UPF0276 family
HER31_RS09640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HER31_RS09645	COG1609	Transcriptional regulator
HER31_RS09650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HER31_RS09655	COG1879	ABC-type sugar transport system periplasmic component
HER31_RS09660	COG1172	Belongs to the binding-protein-dependent transport system permease family
HER31_RS09665	COG1129	ABC transporter
HER31_RS09675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HER31_RS09710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HER31_RS09715	COG1151	hydroxylamine reductase activity
HER31_RS09720	COG0513	Belongs to the DEAD box helicase family
HER31_RS09725	COG1288	antiporter activity
HER31_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS09740	COG1139	Iron-sulfur cluster binding protein
HER31_RS09745	COG0247	lactate metabolic process
HER31_RS09750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HER31_RS09760	COG1984	allophanate hydrolase subunit 2
HER31_RS09765	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HER31_RS09785	COG1506	peptidase
HER31_RS09785	COG0823	Involved in the tonB-independent uptake of proteins
HER31_RS09785	COG4946	Tricorn protease homolog
HER31_RS09805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HER31_RS09810	COG0563	adenylate kinase activity
HER31_RS09815	COG3118	belongs to the thioredoxin family
HER31_RS09820	COG0326	Molecular chaperone. Has ATPase activity
HER31_RS09865	COG0420	3'-5' exonuclease activity
HER31_RS09870	COG0419	ATPase involved in DNA repair
HER31_RS09875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HER31_RS09880	COG1678	Uncharacterized ACR, COG1678
HER31_RS09885	COG0023	Translation Initiation Factor
HER31_RS09905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HER31_RS09910	COG0776	regulation of translation
HER31_RS09915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HER31_RS09920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HER31_RS09925	COG0740	serine-type endopeptidase activity
HER31_RS09950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HER31_RS09960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HER31_RS09965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HER31_RS09980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HER31_RS09985	COG1286	toxin biosynthetic process
HER31_RS09990	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HER31_RS09995	COG0285	dihydrofolate synthase activity
HER31_RS10000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HER31_RS10005	COG0101	tRNA pseudouridine synthase activity
HER31_RS10015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HER31_RS10020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HER31_RS10025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HER31_RS10055	COG0848	biopolymer transport protein
HER31_RS10060	COG0811	peptide transport
HER31_RS10065	COG0811	peptide transport
HER31_RS10090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HER31_RS10095	COG0417	DNA replication proofreading
HER31_RS10100	COG1199	ATP-dependent helicase activity
HER31_RS10105	COG0730	response to heat
HER31_RS10120	COG0123	including yeast histone deacetylase and acetoin utilization protein
HER31_RS10145	COG0179	Fumarylacetoacetate (FAA) hydrolase
HER31_RS10155	COG0426	domain, Protein
HER31_RS10155	COG1773	rubredoxin
HER31_RS10160	COG0446	pyridine nucleotide-disulphide oxidoreductase
HER31_RS10170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HER31_RS10180	COG1404	Belongs to the peptidase S8 family
HER31_RS10200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HER31_RS10205	COG2890	protein-(glutamine-N5) methyltransferase activity
HER31_RS10210	COG2840	Smr protein MutS2
HER31_RS10215	COG2062	phosphohistidine phosphatase, SixA
HER31_RS10220	COG1025	Belongs to the peptidase M16 family
HER31_RS10230	COG1250	3-hydroxyacyl-CoA dehydrogenase
HER31_RS10230	COG1024	Enoyl-CoA hydratase
HER31_RS10235	COG0183	Belongs to the thiolase family
HER31_RS10245	COG0714	Associated with various cellular activities
HER31_RS10320	COG1752	Esterase of the alpha-beta hydrolase superfamily
HER31_RS10325	COG0659	secondary active sulfate transmembrane transporter activity
HER31_RS10345	COG0513	Belongs to the DEAD box helicase family
HER31_RS10355	COG1256	bacterial-type flagellum assembly
HER31_RS10355	COG4786	Flagellar basal body rod
HER31_RS10360	COG3951	Flagellar rod assembly protein muramidase FlgJ
HER31_RS10360	COG1705	Flagellar rod assembly protein muramidase FlgJ
HER31_RS10365	COG1706	bacterial-type flagellum-dependent cell motility
HER31_RS10375	COG4786	Flagellar basal body rod
HER31_RS10380	COG4786	Flagellar basal body rod
HER31_RS10385	COG1749	Flagellar hook protein flgE
HER31_RS10390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HER31_RS10400	COG1815	bacterial-type flagellum-dependent cell motility
HER31_RS10405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HER31_RS10410	COG0784	Response regulator, receiver
HER31_RS10410	COG0835	chemotaxis
HER31_RS10480	COG0270	DNA (cytosine-5-)-methyltransferase activity
HER31_RS10490	COG2186	Transcriptional regulator
HER31_RS10495	COG1053	succinate dehydrogenase
HER31_RS10520	COG0583	DNA-binding transcription factor activity
HER31_RS10550	COG0656	L-ascorbic acid biosynthetic process
HER31_RS10585	COG1858	cytochrome C peroxidase
HER31_RS10590	COG1960	acyl-CoA dehydrogenase activity
HER31_RS10595	COG1250	3-hydroxyacyl-CoA dehydrogenase
HER31_RS10595	COG1024	Enoyl-CoA hydratase
HER31_RS10600	COG0183	Belongs to the thiolase family
HER31_RS10610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HER31_RS10640	COG0318	PFAM AMP-dependent synthetase and ligase
HER31_RS10645	COG4771	TonB-dependent receptor
HER31_RS10675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HER31_RS10685	COG0693	protein deglycase activity
HER31_RS10695	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HER31_RS10700	COG0668	transmembrane transport
HER31_RS10705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HER31_RS10725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HER31_RS10730	COG2963	transposase activity
HER31_RS10735	COG3328	transposase activity
HER31_RS10765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HER31_RS10780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HER31_RS10785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HER31_RS10795	COG2089	acid synthase
HER31_RS10815	COG3104	oligopeptide transport
HER31_RS10830	COG1943	Transposase
HER31_RS10835	COG0646	methionine synthase
HER31_RS10835	COG1410	methionine synthase
HER31_RS10855	COG0835	chemotaxis
HER31_RS10865	COG1192	Involved in chromosome partitioning
HER31_RS10880	COG0643	Histidine kinase
HER31_RS10880	COG2198	Histidine kinase
HER31_RS10880	COG0784	Response regulator, receiver
HER31_RS10885	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HER31_RS10910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HER31_RS10915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HER31_RS10920	COG1684	flagellar biosynthetic protein fliR
HER31_RS10925	COG1987	bacterial-type flagellum assembly
HER31_RS10975	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HER31_RS10980	COG1766	The M ring may be actively involved in energy transduction
HER31_RS10985	COG1677	Flagellar hook-basal body complex protein FliE
HER31_RS10995	COG4191	Histidine kinase
HER31_RS11005	COG1516	flagellar protein fliS
HER31_RS11015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HER31_RS11025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HER31_RS11030	COG1435	thymidine kinase activity
HER31_RS11035	COG1757	Na H antiporter
HER31_RS11060	COG1228	amidohydrolase
HER31_RS11075	COG1720	tRNA m6t6A37 methyltransferase activity
HER31_RS11085	COG0442	prolyl-tRNA aminoacylation
HER31_RS11100	COG0037	tRNA processing
HER31_RS11105	COG0825	malonyl-CoA metabolic process
HER31_RS11110	COG0587	DNA-directed DNA polymerase activity
HER31_RS11115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HER31_RS11120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HER31_RS11125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HER31_RS11135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HER31_RS11145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HER31_RS11150	COG0750	zinc metalloprotease
HER31_RS11155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HER31_RS11160	COG0575	Belongs to the CDS family
HER31_RS11165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HER31_RS11170	COG0233	cytoplasmic translational termination
HER31_RS11175	COG0528	UMP kinase activity
HER31_RS11180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HER31_RS11190	COG0024	Methionine aminopeptidase
HER31_RS11195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HER31_RS11200	COG2171	N-acyltransferase activity
HER31_RS11205	COG1960	acyl-CoA dehydrogenase activity
HER31_RS11215	COG0716	FMN binding
HER31_RS11250	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HER31_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
HER31_RS11280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HER31_RS11290	COG0826	peptidase U32
HER31_RS11295	COG0826	peptidase U32
HER31_RS11305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HER31_RS11310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HER31_RS11315	COG2252	PERMEase
HER31_RS11320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HER31_RS11325	COG2195	Cleaves the N-terminal amino acid of tripeptides
HER31_RS11330	COG2354	Protein conserved in bacteria
HER31_RS11340	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS11350	COG1024	Enoyl-CoA hydratase
HER31_RS11355	COG1960	acyl-CoA dehydrogenase activity
HER31_RS11365	COG0183	Belongs to the thiolase family
HER31_RS11370	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HER31_RS11380	COG0354	folic acid binding
HER31_RS11395	COG1301	dicarboxylic acid transport
HER31_RS11415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HER31_RS11425	COG1757	Na H antiporter
HER31_RS11430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HER31_RS11435	COG2801	Transposase and inactivated derivatives
HER31_RS11460	COG3746	phosphate-selective porin O and P
HER31_RS11475	COG0306	phosphate transporter
HER31_RS11480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HER31_RS11485	COG4974	Belongs to the 'phage' integrase family
HER31_RS11490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS11505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HER31_RS11515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HER31_RS11520	COG0513	Belongs to the DEAD box helicase family
HER31_RS11535	COG0191	fructose-bisphosphate aldolase activity
HER31_RS11540	COG0126	phosphoglycerate kinase activity
HER31_RS11545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HER31_RS11560	COG1280	lysine exporter protein (LysE YggA)
HER31_RS11570	COG0788	formyltetrahydrofolate deformylase activity
HER31_RS11580	COG0243	molybdopterin cofactor binding
HER31_RS11585	COG3062	negative regulation of establishment of protein localization
HER31_RS11590	COG0513	Belongs to the DEAD box helicase family
HER31_RS11615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HER31_RS11620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HER31_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS11680	COG2084	Dehydrogenase
HER31_RS11690	COG2017	converts alpha-aldose to the beta-anomer
HER31_RS11705	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HER31_RS11715	COG0736	holo-[acyl-carrier-protein] synthase activity
HER31_RS11720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HER31_RS11725	COG1381	Involved in DNA repair and RecF pathway recombination
HER31_RS11735	COG0571	ribonuclease III activity
HER31_RS11740	COG0681	Belongs to the peptidase S26 family
HER31_RS11745	COG0481	GTPase activity
HER31_RS11755	COG3026	antisigma factor binding
HER31_RS11765	COG1595	DNA-templated transcription, initiation
HER31_RS11770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HER31_RS11775	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HER31_RS11780	COG2814	Major facilitator Superfamily
HER31_RS11785	COG0583	DNA-binding transcription factor activity
HER31_RS11795	COG1301	dicarboxylic acid transport
HER31_RS11800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HER31_RS11805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HER31_RS11810	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HER31_RS11815	COG0494	nUDIX hydrolase
HER31_RS11820	COG3066	DNA modification
HER31_RS11825	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HER31_RS11860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HER31_RS11885	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS11890	COG3301	Polysulphide reductase, NrfD
HER31_RS11895	COG1053	succinate dehydrogenase
HER31_RS11905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HER31_RS11915	COG3040	lipid binding
HER31_RS11935	COG0346	lactoylglutathione lyase activity
HER31_RS11950	COG3171	Protein conserved in bacteria
HER31_RS12000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HER31_RS12015	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HER31_RS12020	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HER31_RS12065	COG0640	Transcriptional regulator
HER31_RS12070	COG1192	Involved in chromosome partitioning
HER31_RS12080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HER31_RS12090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HER31_RS12095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HER31_RS12110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HER31_RS12110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HER31_RS12115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HER31_RS12125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HER31_RS12130	COG1053	succinate dehydrogenase
HER31_RS12145	COG0488	(ABC) transporter
HER31_RS12165	COG2888	peptidyl-tyrosine sulfation
HER31_RS12170	COG0495	leucyl-tRNA aminoacylation
HER31_RS12175	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HER31_RS12185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HER31_RS12190	COG0799	negative regulation of ribosome biogenesis
HER31_RS12195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HER31_RS12200	COG0768	penicillin binding
HER31_RS12205	COG0772	Belongs to the SEDS family
HER31_RS12210	COG2951	lytic endotransglycosylase activity
HER31_RS12215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HER31_RS12220	COG1686	Belongs to the peptidase S11 family
HER31_RS12225	COG2921	Belongs to the UPF0250 family
HER31_RS12235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HER31_RS12255	COG5002	protein histidine kinase activity
HER31_RS12260	COG0745	RESPONSE REGULATOR receiver
HER31_RS12285	COG3604	Transcriptional regulator
HER31_RS12300	COG3976	FMN-binding domain protein
HER31_RS12300	COG1053	succinate dehydrogenase
HER31_RS12310	COG3301	Polysulphide reductase, NrfD
HER31_RS12315	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS12340	COG0446	pyridine nucleotide-disulphide oxidoreductase
HER31_RS12340	COG1902	pentaerythritol trinitrate reductase activity
HER31_RS12345	COG0583	DNA-binding transcription factor activity
HER31_RS12355	COG2966	Psort location CytoplasmicMembrane, score
HER31_RS12360	COG3610	response to peptide
HER31_RS12365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HER31_RS12370	COG0739	heme binding
HER31_RS12375	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HER31_RS12390	COG0471	metal ion transport
HER31_RS12400	COG1053	succinate dehydrogenase
HER31_RS12410	COG1979	alcohol dehydrogenase
HER31_RS12425	COG4968	Prepilin-type N-terminal cleavage methylation domain
HER31_RS12430	COG0604	alcohol dehydrogenase
HER31_RS12435	COG0583	DNA-binding transcription factor activity
HER31_RS12465	COG0753	catalase activity
HER31_RS12495	COG2084	Dehydrogenase
HER31_RS12500	COG3395	kinase activity
HER31_RS12505	COG0235	Class ii aldolase
HER31_RS12510	COG3622	Belongs to the hyi family
HER31_RS12515	COG2610	gluconate transmembrane transporter activity
HER31_RS12560	COG0778	Nitroreductase
HER31_RS12590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HER31_RS12595	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HER31_RS12600	COG0583	DNA-binding transcription factor activity
HER31_RS12610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HER31_RS12610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HER31_RS12615	COG0509	glycine decarboxylation via glycine cleavage system
HER31_RS12620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HER31_RS12625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HER31_RS12630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HER31_RS12635	COG0006	proline dipeptidase activity
HER31_RS12640	COG3079	Belongs to the UPF0149 family
HER31_RS12660	COG3339	Conserved Protein
HER31_RS12665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HER31_RS12675	COG3084	Protein conserved in bacteria
HER31_RS12680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HER31_RS12685	COG1643	Atp-dependent helicase
HER31_RS12705	COG1489	DNA binding
HER31_RS12715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HER31_RS12725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HER31_RS12730	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HER31_RS12735	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HER31_RS12740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HER31_RS12745	COG2205	protein histidine kinase activity
HER31_RS12745	COG5002	protein histidine kinase activity
HER31_RS12745	COG0784	Response regulator, receiver
HER31_RS12755	COG2172	sigma factor antagonist activity
HER31_RS12760	COG1366	Belongs to the anti-sigma-factor antagonist family
HER31_RS12765	COG1366	Belongs to the anti-sigma-factor antagonist family
HER31_RS12775	COG0519	Catalyzes the synthesis of GMP from XMP
HER31_RS12790	COG0488	(ABC) transporter
HER31_RS12815	COG0514	ATP-dependent DNA helicase (RecQ)
HER31_RS12820	COG4807	Protein conserved in bacteria
HER31_RS12825	COG0243	molybdopterin cofactor binding
HER31_RS12830	COG1648	precorrin-2 dehydrogenase activity
HER31_RS12830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HER31_RS12835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HER31_RS12835	COG2146	nitrite reductase [NAD(P)H] activity
HER31_RS12840	COG2146	nitrite reductase [NAD(P)H] activity
HER31_RS12850	COG0765	amino acid transport
HER31_RS12855	COG1126	abc transporter atp-binding protein
HER31_RS12880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HER31_RS12920	COG1053	succinate dehydrogenase
HER31_RS12955	COG0484	heat shock protein binding
HER31_RS12990	COG1451	nucleotide metabolic process
HER31_RS13000	COG0385	Bile acid
HER31_RS13005	COG1671	Belongs to the UPF0178 family
HER31_RS13035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HER31_RS13035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HER31_RS13040	COG1560	Kdo2-lipid A biosynthetic process
HER31_RS13045	COG0583	DNA-binding transcription factor activity
HER31_RS13050	COG2814	Major facilitator Superfamily
HER31_RS13055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HER31_RS13065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HER31_RS13070	COG3025	triphosphatase activity
HER31_RS13075	COG1392	Phosphate transport regulator
HER31_RS13080	COG0306	phosphate transporter
HER31_RS13100	COG3267	Type II secretory pathway component ExeA
HER31_RS13100	COG3409	Peptidoglycan-binding domain 1 protein
HER31_RS13110	COG1968	undecaprenyl-diphosphatase activity
HER31_RS13115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HER31_RS13120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HER31_RS13125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HER31_RS13130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HER31_RS13135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HER31_RS13145	COG0358	DNA primase activity
HER31_RS13155	COG1024	Enoyl-CoA hydratase
HER31_RS13160	COG0745	RESPONSE REGULATOR receiver
HER31_RS13165	COG3706	GGDEF domain
HER31_RS13185	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HER31_RS13190	COG0204	Acyl-transferase
HER31_RS13215	COG3150	esterase
HER31_RS13220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HER31_RS13225	COG3151	Protein conserved in bacteria
HER31_RS13230	COG0494	nUDIX hydrolase
HER31_RS13235	COG1538	Outer membrane efflux protein
HER31_RS13255	COG1024	Enoyl-CoA hydratase
HER31_RS13275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HER31_RS13280	COG1022	Amp-dependent synthetase and ligase
HER31_RS13285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HER31_RS13300	COG4608	Belongs to the ABC transporter superfamily
HER31_RS13310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HER31_RS13315	COG0601	transmembrane transport
HER31_RS13330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HER31_RS13335	COG0305	Participates in initiation and elongation during chromosome replication
HER31_RS13370	COG1566	PFAM secretion protein HlyD family protein
HER31_RS13380	COG1716	ATPase activity
HER31_RS13380	COG5001	Diguanylate cyclase
HER31_RS13385	COG1760	l-serine dehydratase
HER31_RS13390	COG0814	amino acid
HER31_RS13395	COG0730	response to heat
HER31_RS13400	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HER31_RS13405	COG2366	antibiotic biosynthetic process
HER31_RS13410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HER31_RS13415	COG2166	iron-sulfur cluster assembly
HER31_RS13420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HER31_RS13430	COG0515	serine threonine protein kinase
HER31_RS13435	COG2832	Protein of unknown function (DUF454)
HER31_RS13445	COG0737	Belongs to the 5'-nucleotidase family
HER31_RS13455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HER31_RS13460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HER31_RS13465	COG2239	Acts as a magnesium transporter
HER31_RS13470	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HER31_RS13475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HER31_RS13485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HER31_RS13490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HER31_RS13500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HER31_RS13505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HER31_RS13510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HER31_RS13520	COG2967	ApaG domain
HER31_RS13545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HER31_RS13550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HER31_RS13555	COG0142	geranyltranstransferase activity
HER31_RS13575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HER31_RS13585	COG1012	belongs to the aldehyde dehydrogenase family
HER31_RS13600	COG3954	Phosphoribulokinase
HER31_RS13610	COG0429	hydrolase of the alpha beta-hydrolase fold
HER31_RS13620	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HER31_RS13630	COG0488	(ABC) transporter
HER31_RS13635	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HER31_RS13650	COG0242	peptide deformylase activity
HER31_RS13655	COG2900	Belongs to the SlyX family
HER31_RS13660	COG3112	Uncharacterised protein family (UPF0231)
HER31_RS13665	COG2197	response regulator
HER31_RS13670	COG3850	Histidine kinase
HER31_RS13675	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HER31_RS13680	COG0347	Belongs to the P(II) protein family
HER31_RS13685	COG0004	ammonium transporteR
HER31_RS13690	COG0039	L-malate dehydrogenase activity
HER31_RS13695	COG1438	arginine binding
HER31_RS13700	COG2837	iron assimilation
HER31_RS13705	COG3842	ATPase activity
HER31_RS13785	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HER31_RS13790	COG2969	positive regulation of protein catabolic process
HER31_RS13795	COG0625	glutathione transferase activity
HER31_RS13800	COG2857	Cytochrome c1
HER31_RS13805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HER31_RS13810	COG0723	plastoquinol--plastocyanin reductase activity
HER31_RS13815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HER31_RS13820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HER31_RS13825	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HER31_RS13835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HER31_RS13845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HER31_RS13850	COG5007	Belongs to the BolA IbaG family
HER31_RS13860	COG2854	intermembrane phospholipid transfer
HER31_RS13865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HER31_RS13870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HER31_RS13875	COG1127	ABC transporter
HER31_RS13890	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HER31_RS13900	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HER31_RS13905	COG1137	ATPase activity
HER31_RS13910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HER31_RS13930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HER31_RS13940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HER31_RS13950	COG0312	modulator of DNA gyrase
HER31_RS13955	COG3028	Belongs to the UPF0307 family
HER31_RS13970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS13980	COG0312	modulator of DNA gyrase
HER31_RS13985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HER31_RS13995	COG1530	ribonuclease E activity
HER31_RS14000	COG0424	maF-like protein
HER31_RS14005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HER31_RS14010	COG1792	Involved in formation and maintenance of cell shape
HER31_RS14015	COG1077	Cell shape determining protein MreB Mrl
HER31_RS14045	COG4969	Belongs to the N-Me-Phe pilin family
HER31_RS14060	COG1459	type II secretion system
HER31_RS14065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HER31_RS14075	COG3267	Type II secretory pathway component ExeA
HER31_RS14075	COG3409	Peptidoglycan-binding domain 1 protein
HER31_RS14105	COG2200	EAL domain
HER31_RS14105	COG2199	diguanylate cyclase activity
HER31_RS14185	COG0629	single-stranded DNA binding
HER31_RS14195	COG2814	Major facilitator Superfamily
HER31_RS14200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HER31_RS14210	COG1053	succinate dehydrogenase
HER31_RS14225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HER31_RS14230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HER31_RS14250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HER31_RS14255	COG0460	homoserine dehydrogenase
HER31_RS14255	COG0527	aspartate kinase activity
HER31_RS14260	COG0626	cystathionine gamma-synthase activity
HER31_RS14265	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HER31_RS14285	COG0281	malic enzyme
HER31_RS14290	COG2885	chlorophyll binding
HER31_RS14295	COG0254	rRNA binding
HER31_RS14300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HER31_RS14305	COG0018	arginyl-trna synthetase
HER31_RS14330	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HER31_RS14335	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HER31_RS14350	COG0702	epimerase
HER31_RS14360	COG0671	phosphoesterase, PA-phosphatase related
HER31_RS14385	COG2226	methyltransferase
HER31_RS14400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HER31_RS14405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HER31_RS14410	COG0805	protein transport
HER31_RS14420	COG0084	hydrolase, TatD family'
HER31_RS14435	COG2962	Rard protein
HER31_RS14440	COG0446	pyridine nucleotide-disulphide oxidoreductase
HER31_RS14455	COG0248	Ppx GppA phosphatase
HER31_RS14460	COG0513	Belongs to the DEAD box helicase family
HER31_RS14465	COG3118	belongs to the thioredoxin family
HER31_RS14485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HER31_RS14500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HER31_RS14510	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS14515	COG3383	formate dehydrogenase (NAD+) activity
HER31_RS14555	COG3852	Histidine kinase
HER31_RS14560	COG2204	response regulator
HER31_RS14580	COG0746	molybdenum cofactor guanylyltransferase activity
HER31_RS14585	COG0303	'Molybdopterin
HER31_RS14590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HER31_RS14650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HER31_RS14655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HER31_RS14670	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HER31_RS14680	COG3381	protein complex oligomerization
HER31_RS14685	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS14690	COG0243	molybdopterin cofactor binding
HER31_RS14705	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS14710	COG0243	molybdopterin cofactor binding
HER31_RS14750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HER31_RS14760	COG0583	DNA-binding transcription factor activity
HER31_RS14770	COG1053	succinate dehydrogenase
HER31_RS14780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HER31_RS14795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HER31_RS14800	COG0129	dihydroxy-acid dehydratase activity
HER31_RS14805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HER31_RS14810	COG0028	Belongs to the TPP enzyme family
HER31_RS14820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HER31_RS14825	COG0606	chelatase, subunit chli
HER31_RS14910	COG0606	chelatase, subunit chli
HER31_RS14920	COG0204	Acyl-transferase
HER31_RS14925	COG0204	Acyl-transferase
HER31_RS14930	COG1802	Transcriptional regulator
HER31_RS14935	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HER31_RS14940	COG0372	Belongs to the citrate synthase family
HER31_RS14950	COG2828	Protein conserved in bacteria
HER31_RS14955	COG4968	Prepilin-type N-terminal cleavage methylation domain
HER31_RS14970	COG3074	FtsZ-dependent cytokinesis
HER31_RS14980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HER31_RS14985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HER31_RS14995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HER31_RS15005	COG2067	long-chain fatty acid transport protein
HER31_RS15010	COG0066	3-isopropylmalate dehydratase activity
HER31_RS15015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HER31_RS15020	COG0473	3-isopropylmalate dehydrogenase activity
HER31_RS15025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HER31_RS15035	COG0514	ATP-dependent DNA helicase (RecQ)
HER31_RS15040	COG2050	protein possibly involved in aromatic compounds catabolism
HER31_RS15045	COG2962	Rard protein
HER31_RS15055	COG2959	enzyme of heme biosynthesis
HER31_RS15060	COG1587	Uroporphyrinogen-III synthase
HER31_RS15065	COG0181	hydroxymethylbilane synthase activity
HER31_RS15070	COG3072	Adenylate cyclase
HER31_RS15100	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HER31_RS15105	COG1477	protein flavinylation
HER31_RS15130	COG1011	Hydrolase
HER31_RS15150	COG0745	RESPONSE REGULATOR receiver
HER31_RS15155	COG2205	protein histidine kinase activity
HER31_RS15180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HER31_RS15185	COG3122	Protein conserved in bacteria
HER31_RS15200	COG3191	aminopeptidase activity
HER31_RS15225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HER31_RS15230	COG0583	DNA-binding transcription factor activity
HER31_RS15270	COG0814	amino acid
HER31_RS15280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HER31_RS15285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HER31_RS15300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HER31_RS15305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HER31_RS15310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HER31_RS15315	COG0702	epimerase
HER31_RS15325	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HER31_RS15330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HER31_RS15345	COG0583	DNA-binding transcription factor activity
HER31_RS15375	COG2211	Major facilitator Superfamily
HER31_RS15380	COG1528	Iron-storage protein
HER31_RS15400	COG0339	signal peptide processing
HER31_RS15410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HER31_RS15425	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS15445	COG1309	transcriptional regulator
HER31_RS15450	COG1053	succinate dehydrogenase
HER31_RS15450	COG3976	FMN-binding domain protein
HER31_RS15475	COG1522	sequence-specific DNA binding
HER31_RS15485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HER31_RS15495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HER31_RS15515	COG0318	PFAM AMP-dependent synthetase and ligase
HER31_RS15550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HER31_RS15560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HER31_RS15575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HER31_RS15580	COG0551	DNA topoisomerase type I activity
HER31_RS15585	COG2922	Belongs to the Smg family
HER31_RS15590	COG0758	DNA mediated transformation
HER31_RS15600	COG0242	peptide deformylase activity
HER31_RS15605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HER31_RS15610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HER31_RS15610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HER31_RS15615	COG0569	domain protein
HER31_RS15630	COG0640	Transcriptional regulator
HER31_RS15640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HER31_RS15645	COG1739	Uncharacterized protein family UPF0029
HER31_RS15655	COG1024	Enoyl-CoA hydratase
HER31_RS15655	COG1250	3-hydroxyacyl-CoA dehydrogenase
HER31_RS15665	COG0425	Belongs to the sulfur carrier protein TusA family
HER31_RS15670	COG4946	Tricorn protease homolog
HER31_RS15670	COG1506	peptidase
HER31_RS15670	COG0823	Involved in the tonB-independent uptake of proteins
HER31_RS15675	COG2818	Glycosylase
HER31_RS15680	COG0752	glycyl-tRNA synthetase alpha subunit
HER31_RS15690	COG0516	GMP reductase activity
HER31_RS15695	COG0393	Putative heavy-metal-binding
HER31_RS15700	COG0187	DNA topoisomerase II activity
HER31_RS15715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HER31_RS15720	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HER31_RS15725	COG0594	ribonuclease P activity
HER31_RS15735	COG0706	membrane insertase activity
HER31_RS15740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HER31_RS15745	COG0716	FMN binding
HER31_RS15750	COG0445	tRNA wobble uridine modification
HER31_RS15755	COG0357	Ribosomal RNA small subunit methyltransferase G
HER31_RS15760	COG1192	Involved in chromosome partitioning
HER31_RS15765	COG1475	DNA binding
HER31_RS15775	COG0356	it plays a direct role in the translocation of protons across the membrane
HER31_RS15785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HER31_RS15790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HER31_RS15795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HER31_RS15800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HER31_RS15805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HER31_RS15820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HER31_RS15830	COG1349	DNA-binding transcription factor activity
HER31_RS15835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HER31_RS15885	COG1022	Amp-dependent synthetase and ligase
HER31_RS15895	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HER31_RS15900	COG0668	transmembrane transport
HER31_RS15915	COG2095	MarC family integral membrane protein
HER31_RS15925	COG0742	ribosomal rna small subunit methyltransferase
HER31_RS15930	COG0552	protein localization to endoplasmic reticulum
HER31_RS15935	COG2884	Cell division ATP-binding protein ftsE
HER31_RS15940	COG2177	Part of the ABC transporter FtsEX involved in
HER31_RS15945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HER31_RS15965	COG0243	molybdopterin cofactor binding
HER31_RS15970	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS15975	COG3381	protein complex oligomerization
HER31_RS15980	COG2861	carbohydrate metabolic process
HER31_RS15985	COG0793	Belongs to the peptidase S41A family
HER31_RS15990	COG4942	peptidase
HER31_RS15995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HER31_RS16000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HER31_RS16005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HER31_RS16010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HER31_RS16015	COG2081	HI0933 family
HER31_RS16035	COG0583	DNA-binding transcription factor activity
HER31_RS16040	COG2116	formate transmembrane transporter activity
HER31_RS16045	COG5001	Diguanylate cyclase
HER31_RS16050	COG2267	carboxylic ester hydrolase activity
HER31_RS16065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HER31_RS16075	COG3078	GTPase activator activity
HER31_RS16090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HER31_RS16095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HER31_RS16095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HER31_RS16100	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HER31_RS16110	COG1418	mRNA catabolic process
HER31_RS16115	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HER31_RS16120	COG0303	'Molybdopterin
HER31_RS16125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HER31_RS16130	COG2261	transglycosylase associated protein
HER31_RS16140	COG0564	pseudouridine synthase activity
HER31_RS16145	COG0314	molybdopterin synthase activity
HER31_RS16150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HER31_RS16155	COG0315	cyclic pyranopterin monophosphate synthase activity
HER31_RS16160	COG0521	Mo-molybdopterin cofactor biosynthetic process
HER31_RS16165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HER31_RS16185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HER31_RS16190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HER31_RS16195	COG3706	GGDEF domain
HER31_RS16200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HER31_RS16220	COG0437	4 iron, 4 sulfur cluster binding
HER31_RS16225	COG0243	molybdopterin cofactor binding
HER31_RS16225	COG3383	formate dehydrogenase (NAD+) activity
HER31_RS16240	COG3852	Histidine kinase
HER31_RS16250	COG0174	glutamine synthetase
HER31_RS16260	COG4106	trans-aconitate 2-methyltransferase activity
HER31_RS16265	COG1187	pseudouridine synthase activity
HER31_RS16280	COG1295	ribonuclease BN
HER31_RS16285	COG1490	D-aminoacyl-tRNA deacylase activity
HER31_RS16295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HER31_RS16300	COG1022	Amp-dependent synthetase and ligase
HER31_RS16305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HER31_RS16315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HER31_RS16320	COG1758	RNA polymerase activity
HER31_RS16330	COG1322	Protein conserved in bacteria
HER31_RS16335	COG1957	nucleoside hydrolase
HER31_RS16340	COG0798	PFAM Bile acid sodium symporter
HER31_RS16380	COG1561	YicC-like family, N-terminal region
HER31_RS16390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HER31_RS16395	COG1309	transcriptional regulator
HER31_RS16400	COG0756	dUTP diphosphatase activity
HER31_RS16405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HER31_RS16410	COG2003	Belongs to the UPF0758 family
HER31_RS16415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HER31_RS16425	COG2755	lipolytic protein G-D-S-L family
HER31_RS16425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HER31_RS16435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HER31_RS16440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HER31_RS16450	COG0859	PFAM glycosyl transferase family 9
HER31_RS16460	COG0438	transferase activity, transferring glycosyl groups
HER31_RS16465	COG0297	glycogen (starch) synthase activity
HER31_RS16470	COG0463	Glycosyl transferase, family 2
HER31_RS16480	COG0438	transferase activity, transferring glycosyl groups
HER31_RS16485	COG0438	transferase activity, transferring glycosyl groups
HER31_RS16500	COG0859	PFAM glycosyl transferase family 9
HER31_RS16505	COG3642	lipopolysaccharide core region biosynthetic process
HER31_RS16510	COG1519	Transferase
HER31_RS16525	COG0156	8-amino-7-oxononanoate synthase activity
HER31_RS16530	COG1063	alcohol dehydrogenase
HER31_RS16565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS16570	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HER31_RS16575	COG0625	glutathione transferase activity
HER31_RS16585	COG0330	HflC and HflK could
HER31_RS16635	COG2937	Belongs to the GPAT DAPAT family
HER31_RS16640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HER31_RS16650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HER31_RS16650	COG1565	acr, cog1565
HER31_RS16655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HER31_RS16660	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HER31_RS16665	COG1845	cytochrome c oxidase, subunit III
HER31_RS16685	COG1612	heme a metabolic process
HER31_RS16690	COG0109	protoheme IX farnesyltransferase activity
HER31_RS16700	COG0726	polysaccharide deacetylase
HER31_RS16700	COG1649	PFAM Uncharacterised BCR, COG1649
HER31_RS16705	COG0534	Mate efflux family protein
HER31_RS16710	COG2199	diguanylate cyclase activity
HER31_RS16715	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HER31_RS16715	COG0316	Belongs to the HesB IscA family
HER31_RS16720	COG1040	competence protein
HER31_RS16725	COG0596	Alpha beta hydrolase
HER31_RS16735	COG2183	response to ionizing radiation
HER31_RS16740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HER31_RS16745	COG0745	RESPONSE REGULATOR receiver
HER31_RS16755	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HER31_RS16760	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HER31_RS16770	COG3031	protein transport across the cell outer membrane
HER31_RS16780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HER31_RS16785	COG1459	type II secretion system
HER31_RS16790	COG2165	general secretion pathway protein
HER31_RS16800	COG2165	general secretion pathway protein
HER31_RS16805	COG4795	General secretion pathway protein
HER31_RS16810	COG3156	type II secretion system protein K
HER31_RS16820	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HER31_RS16830	COG0494	nUDIX hydrolase
HER31_RS16835	COG1218	3'(2'),5'-bisphosphate nucleotidase
HER31_RS16840	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HER31_RS16865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HER31_RS16900	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HER31_RS16900	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HER31_RS16905	COG1072	(Pantothenic acid kinase))
HER31_RS16930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HER31_RS16935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HER31_RS16945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HER31_RS16950	COG0081	regulation of translation
HER31_RS16955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HER31_RS16960	COG0222	ribosome binding
HER31_RS16970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HER31_RS16975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HER31_RS16980	COG0049	tRNA binding
HER31_RS16985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HER31_RS16990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HER31_RS17020	COG0438	transferase activity, transferring glycosyl groups
HER31_RS17025	COG1215	transferase activity, transferring glycosyl groups
HER31_RS17040	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HER31_RS17040	COG0662	Cupin 2, conserved barrel domain protein
HER31_RS17045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HER31_RS17050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HER31_RS17070	COG0051	transcription antitermination factor activity, RNA binding
HER31_RS17075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HER31_RS17080	COG0088	Forms part of the polypeptide exit tunnel
HER31_RS17090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HER31_RS17095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HER31_RS17100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HER31_RS17105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HER31_RS17110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HER31_RS17120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HER31_RS17125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HER31_RS17130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HER31_RS17135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HER31_RS17155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HER31_RS17160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HER31_RS17165	COG1841	ribosomal large subunit assembly
HER31_RS17170	COG0200	Binds to the 23S rRNA
HER31_RS17175	COG0201	protein transport
HER31_RS17180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HER31_RS17185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HER31_RS17190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HER31_RS17195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HER31_RS17200	COG0202	RNA polymerase activity
HER31_RS17205	COG0203	ribosomal protein L17
HER31_RS17215	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HER31_RS17225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HER31_RS17230	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HER31_RS17235	COG4133	protoheme IX ABC transporter activity
HER31_RS17245	COG4235	cytochrome complex assembly
HER31_RS17245	COG3088	subunit of a heme lyase
HER31_RS17265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HER31_RS17300	COG1546	Belongs to the CinA family
HER31_RS17300	COG1058	Belongs to the CinA family
HER31_RS17310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HER31_RS17315	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HER31_RS17320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HER31_RS17335	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HER31_RS17335	COG0165	Argininosuccinate lyase
HER31_RS17340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HER31_RS17370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HER31_RS17375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HER31_RS17385	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HER31_RS17400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HER31_RS17405	COG0546	phosphoglycolate phosphatase activity
HER31_RS17410	COG0180	Tryptophanyl-tRNA synthetase
HER31_RS17415	COG2823	Periplasmic or secreted lipoprotein
HER31_RS17420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HER31_RS17425	COG0792	nuclease activity
HER31_RS17430	COG3107	peptidoglycan biosynthetic process
HER31_RS17435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HER31_RS17450	COG2001	Belongs to the MraZ family
HER31_RS17455	COG0275	rRNA processing
HER31_RS17460	COG3116	cell division
HER31_RS17465	COG0768	penicillin binding
HER31_RS17470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HER31_RS17475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HER31_RS17480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HER31_RS17485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HER31_RS17490	COG0772	Belongs to the SEDS family
HER31_RS17495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HER31_RS17500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HER31_RS17510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HER31_RS17515	COG0849	cell division
HER31_RS17520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HER31_RS17525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HER31_RS17535	COG0739	heme binding
HER31_RS17540	COG0653	protein targeting
HER31_RS17545	COG0494	nUDIX hydrolase
HER31_RS17565	COG0237	dephospho-CoA kinase activity
HER31_RS17570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HER31_RS17575	COG1459	type II secretion system
HER31_RS17580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HER31_RS17600	COG3023	N-Acetylmuramoyl-L-alanine amidase
HER31_RS17610	COG2186	Transcriptional regulator
HER31_RS17615	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HER31_RS17620	COG0508	dehydrogenase complex catalyzes the overall conversion of
HER31_RS17625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HER31_RS17635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HER31_RS17645	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HER31_RS17650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HER31_RS17660	COG1522	sequence-specific DNA binding
HER31_RS17660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HER31_RS17665	COG2313	pseudouridylate synthase activity
HER31_RS17670	COG1573	uracil-dna glycosylase
HER31_RS17675	COG5002	protein histidine kinase activity
HER31_RS17675	COG5001	Diguanylate cyclase
HER31_RS17680	COG4667	esterase of the alpha-beta hydrolase superfamily
HER31_RS17685	COG1032	radical SAM domain protein
HER31_RS17690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HER31_RS17700	COG0494	nUDIX hydrolase
HER31_RS17705	COG1643	Atp-dependent helicase
HER31_RS17735	COG0151	Belongs to the GarS family
HER31_RS17740	COG0138	bifunctional purine biosynthesis protein purh
HER31_RS17760	COG2431	L-lysine efflux transmembrane transporter activity
HER31_RS17775	COG0513	Belongs to the DEAD box helicase family
HER31_RS17780	COG2885	chlorophyll binding
HER31_RS17795	COG0471	metal ion transport
HER31_RS17805	COG0217	transcriptional regulatory protein
HER31_RS17820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HER31_RS17855	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HER31_RS17860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HER31_RS17865	COG2264	protein methyltransferase activity
HER31_RS17875	COG1053	succinate dehydrogenase
HER31_RS17880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HER31_RS17890	COG0439	Biotin carboxylase
HER31_RS17895	COG0511	ligase activity, forming carbon-carbon bonds
HER31_RS17900	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HER31_RS17925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HER31_RS17930	COG1136	(ABC) transporter
HER31_RS17930	COG0577	efflux transmembrane transporter activity
HER31_RS17935	COG0577	efflux transmembrane transporter activity
HER31_RS17935	COG1136	(ABC) transporter
HER31_RS17940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS17945	COG4232	protein-disulfide reductase activity
HER31_RS17950	COG1324	tolerance protein
HER31_RS17955	COG3030	protein affecting phage T7 exclusion by the F plasmid
HER31_RS17960	COG0534	Mate efflux family protein
HER31_RS17970	COG0459	protein refolding
HER31_RS17985	COG1902	pentaerythritol trinitrate reductase activity
HER31_RS17995	COG1252	NADH dehydrogenase
HER31_RS18020	COG1509	lysine 2,3-aminomutase activity
HER31_RS18030	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HER31_RS18060	COG2906	2 iron, 2 sulfur cluster binding
HER31_RS18070	COG0584	glycerophosphoryl diester phosphodiesterase
HER31_RS18075	COG3264	Mechanosensitive ion channel
HER31_RS18075	COG1511	domain protein
HER31_RS18080	COG0688	phosphatidylethanolamine metabolic process
HER31_RS18085	COG1162	GTPase activity
HER31_RS18090	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HER31_RS18125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HER31_RS18125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HER31_RS18130	COG0802	atpase or kinase
HER31_RS18135	COG1388	LysM domain
HER31_RS18135	COG0860	N-Acetylmuramoyl-L-alanine amidase
HER31_RS18145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HER31_RS18150	COG1923	regulation of RNA biosynthetic process
HER31_RS18155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HER31_RS18160	COG0330	HflC and HflK could
HER31_RS18165	COG0330	HflC and HflK could
HER31_RS18170	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HER31_RS18175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HER31_RS18180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HER31_RS18185	COG0557	exoribonuclease II activity
HER31_RS18190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HER31_RS18205	COG2965	DNA replication, synthesis of RNA primer
HER31_RS18210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HER31_RS18215	COG0359	binds to the 23S rRNA
HER31_RS18230	COG1902	pentaerythritol trinitrate reductase activity
HER31_RS18230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HER31_RS18240	COG1116	anion transmembrane transporter activity
HER31_RS18250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HER31_RS18265	COG0848	biopolymer transport protein
HER31_RS18275	COG0811	peptide transport
HER31_RS18295	COG1120	ATPase activity
HER31_RS18310	COG4771	TonB-dependent receptor
HER31_RS18345	COG0737	Belongs to the 5'-nucleotidase family
HER31_RS18350	COG0737	Belongs to the 5'-nucleotidase family
HER31_RS18365	COG1086	Polysaccharide biosynthesis protein
HER31_RS18410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HER31_RS18420	COG0795	lipopolysaccharide-transporting ATPase activity
HER31_RS18425	COG0795	lipopolysaccharide-transporting ATPase activity
HER31_RS18430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HER31_RS18440	COG0525	valine-tRNA ligase activity
HER31_RS18475	COG0316	Belongs to the HesB IscA family
HER31_RS18485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HER31_RS18505	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HER31_RS18510	COG1122	ATPase activity
HER31_RS18530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HER31_RS18535	COG0309	Hydrogenase expression formation protein (HypE)
HER31_RS18540	COG0409	Hydrogenase expression formation protein
HER31_RS18545	COG0298	carbon dioxide binding
HER31_RS18550	COG0339	signal peptide processing
HER31_RS18555	COG0583	DNA-binding transcription factor activity
HER31_RS18565	COG1028	Short-chain dehydrogenase reductase Sdr
HER31_RS18585	COG1752	Esterase of the alpha-beta hydrolase superfamily
HER31_RS18600	COG1024	Enoyl-CoA hydratase
HER31_RS18620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HER31_RS18625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HER31_RS18630	COG0175	sulfate reduction
HER31_RS18650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HER31_RS18655	COG0786	glutamate:sodium symporter activity
HER31_RS18680	COG2815	serine threonine protein kinase
HER31_RS18680	COG0515	serine threonine protein kinase
HER31_RS18685	COG0631	protein serine/threonine phosphatase activity
HER31_RS18700	COG0493	'glutamate synthase
HER31_RS18705	COG0070	glutamate synthase
HER31_RS18705	COG0069	glutamate synthase activity
HER31_RS18705	COG0067	glutamate synthase
HER31_RS18710	COG1242	4 iron, 4 sulfur cluster binding
HER31_RS18735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HER31_RS18735	COG1648	precorrin-2 dehydrogenase activity