locus-tag	class	description
fad_RS00030	COG2814	Major facilitator Superfamily
fad_RS00040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
fad_RS00050	COG3386	PFAM SMP-30 Gluconolaconase
fad_RS00060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
fad_RS00075	COG0730	response to heat
fad_RS00080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
fad_RS00090	COG0024	Methionine aminopeptidase
fad_RS00095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
fad_RS00125	COG0501	Belongs to the peptidase M48B family
fad_RS00160	COG0708	Exodeoxyribonuclease III
fad_RS00180	COG2271	Major facilitator Superfamily
fad_RS00195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
fad_RS00200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
fad_RS00235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
fad_RS00250	COG0183	Belongs to the thiolase family
fad_RS00290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
fad_RS00290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
fad_RS00340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
fad_RS00350	COG1131	(ABC) transporter
fad_RS00385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
fad_RS00390	COG0284	orotidine-5'-phosphate decarboxylase activity
fad_RS00400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
fad_RS00405	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
fad_RS00410	COG1492	cobalamin metabolic process
fad_RS00440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
fad_RS00465	COG0456	acetyltransferase
fad_RS00485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
fad_RS00495	COG0512	Glutamine amidotransferase of anthranilate synthase
fad_RS00495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
fad_RS00500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
fad_RS00505	COG0135	phosphoribosylanthranilate isomerase activity
fad_RS00510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
fad_RS00515	COG0159	tryptophan synthase activity
fad_RS00520	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
fad_RS00525	COG0149	triose-phosphate isomerase activity
fad_RS00545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
fad_RS00550	COG0509	glycine decarboxylation via glycine cleavage system
fad_RS00555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
fad_RS00575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
fad_RS00600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
fad_RS00620	COG2095	MarC family integral membrane protein
fad_RS00625	COG0606	chelatase, subunit chli
fad_RS00630	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
fad_RS00650	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
fad_RS00655	COG0776	regulation of translation
fad_RS00660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
fad_RS00665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
fad_RS00685	COG1322	Protein conserved in bacteria
fad_RS00705	COG2814	Major facilitator Superfamily
fad_RS00745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
fad_RS00760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
fad_RS00775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
fad_RS00780	COG0088	Forms part of the polypeptide exit tunnel
fad_RS00785	COG0089	rRNA binding
fad_RS00790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
fad_RS00800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
fad_RS00810	COG0255	Belongs to the universal ribosomal protein uL29 family
fad_RS00825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
fad_RS00830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
fad_RS00845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
fad_RS00855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
fad_RS00860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
fad_RS00880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
fad_RS00910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
fad_RS00915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
fad_RS00925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
fad_RS00945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
fad_RS00960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
fad_RS00965	COG0181	hydroxymethylbilane synthase activity
fad_RS00995	COG0531	amino acid
fad_RS01005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
fad_RS01010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
fad_RS01015	COG0085	RNA polymerase activity
fad_RS01030	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
fad_RS01035	COG0180	Tryptophanyl-tRNA synthetase
fad_RS01045	COG2271	Major facilitator Superfamily
fad_RS01070	COG0109	protoheme IX farnesyltransferase activity
fad_RS01100	COG0010	Belongs to the arginase family
fad_RS01130	COG0101	tRNA pseudouridine synthase activity
fad_RS01190	COG0667	Aldo Keto reductase
fad_RS01275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
fad_RS01280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
fad_RS01285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
fad_RS01305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
fad_RS01325	COG0163	prenyltransferase activity
fad_RS01340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
fad_RS01350	COG1619	proteins homologs of microcin C7 resistance protein MccF
fad_RS01370	COG0626	cystathionine gamma-synthase activity
fad_RS01375	COG0017	Asparaginyl-tRNA synthetase
fad_RS01400	COG0049	tRNA binding
fad_RS01410	COG0012	GTP binding
fad_RS01420	COG0371	Dehydrogenase
fad_RS01430	COG4974	Belongs to the 'phage' integrase family
fad_RS01435	COG0142	geranyltranstransferase activity
fad_RS01445	COG1063	alcohol dehydrogenase
fad_RS01450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
fad_RS01465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
fad_RS01480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
fad_RS01485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
fad_RS01485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
fad_RS01490	COG0584	glycerophosphoryl diester phosphodiesterase
fad_RS01510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
fad_RS01520	COG0495	leucyl-tRNA aminoacylation
fad_RS01525	COG1945	arginine decarboxylase activity
fad_RS01530	COG1201	RNA secondary structure unwinding
fad_RS01550	COG1139	Iron-sulfur cluster binding protein
fad_RS01560	COG0308	aminopeptidase N
fad_RS01580	COG1741	Belongs to the pirin family
fad_RS01590	COG1131	(ABC) transporter
fad_RS01595	COG2723	6-phospho-beta-galactosidase activity
fad_RS01600	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
fad_RS01605	COG0285	dihydrofolate synthase activity
fad_RS01625	COG0047	phosphoribosylformylglycinamidine synthase activity
fad_RS01635	COG1980	fructose-bisphosphate aldolase activity
fad_RS01670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
fad_RS01685	COG0446	pyridine nucleotide-disulphide oxidoreductase
fad_RS01700	COG0714	Associated with various cellular activities
fad_RS01710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
fad_RS01720	COG0148	phosphopyruvate hydratase activity
fad_RS01730	COG0470	DNA polymerase III
fad_RS01730	COG1067	ATP-dependent peptidase activity
fad_RS01740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
fad_RS01740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
fad_RS01760	COG0714	Associated with various cellular activities
fad_RS01775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
fad_RS01790	COG0438	transferase activity, transferring glycosyl groups
fad_RS01810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
fad_RS01820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
fad_RS01840	COG0187	DNA topoisomerase II activity
fad_RS01845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
fad_RS01850	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
fad_RS01860	COG0531	amino acid
fad_RS01875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
fad_RS01880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
fad_RS01905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
fad_RS01910	COG0805	protein transport
fad_RS01935	COG1881	PFAM PEBP family protein
fad_RS01960	COG0552	protein localization to endoplasmic reticulum
fad_RS01970	COG0126	phosphoglycerate kinase activity
fad_RS01990	COG1515	deoxyribonuclease V activity
fad_RS01995	COG2409	Drug exporters of the RND superfamily
fad_RS02010	COG3769	mannosylglycerate metabolic process
fad_RS02015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
fad_RS02020	COG0006	proline dipeptidase activity
fad_RS02040	COG1132	(ABC) transporter
fad_RS02045	COG1132	(ABC) transporter
fad_RS02100	COG0588	phosphoglycerate mutase activity
fad_RS02105	COG1331	Highly conserved protein containing a thioredoxin domain
fad_RS02115	COG2235	arginine
fad_RS02130	COG3420	alginic acid biosynthetic process
fad_RS02145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
fad_RS02160	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
fad_RS02175	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
fad_RS02225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
fad_RS02230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
fad_RS02280	COG0557	exoribonuclease II activity
fad_RS02285	COG0017	Asparaginyl-tRNA synthetase
fad_RS02290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
fad_RS02295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
fad_RS02300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
fad_RS02305	COG0151	Belongs to the GarS family
fad_RS02320	COG0717	Belongs to the dCTP deaminase family
fad_RS02325	COG1056	cytidyltransferase-related domain
fad_RS02325	COG1051	belongs to the nudix hydrolase family
fad_RS02330	COG0417	DNA replication proofreading
fad_RS02360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
fad_RS02360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
fad_RS02410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
fad_RS02440	COG3387	PFAM Glycoside hydrolase 15-related
fad_RS02465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
fad_RS02470	COG1335	isochorismatase
fad_RS02480	COG1192	Involved in chromosome partitioning
fad_RS02485	COG1028	Short-chain dehydrogenase reductase Sdr
fad_RS02495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
fad_RS02500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
fad_RS02505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
fad_RS02510	COG0189	ligase activity
fad_RS02515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
fad_RS02525	COG1250	3-hydroxyacyl-CoA dehydrogenase
fad_RS02530	COG0318	PFAM AMP-dependent synthetase and ligase
fad_RS02535	COG0183	Belongs to the thiolase family
fad_RS02540	COG1960	acyl-CoA dehydrogenase activity
fad_RS02545	COG1960	acyl-CoA dehydrogenase activity
fad_RS02550	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
fad_RS02555	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
fad_RS02560	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
fad_RS02575	COG1355	regulation of microtubule-based process
fad_RS02620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
fad_RS02625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
fad_RS02635	COG0484	heat shock protein binding
fad_RS02660	COG0154	amidase activity
fad_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
fad_RS02680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
fad_RS02720	COG1196	nuclear chromosome segregation
fad_RS02725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
fad_RS02735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
fad_RS02745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
fad_RS02745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
fad_RS02760	COG2814	Major facilitator Superfamily
fad_RS02765	COG2222	sugar isomerase
fad_RS02775	COG2267	carboxylic ester hydrolase activity
fad_RS02790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
fad_RS02790	COG0674	pyruvate-flavodoxin oxidoreductase activity
fad_RS02795	COG1013	pyruvate-flavodoxin oxidoreductase activity
fad_RS02815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
fad_RS02835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
fad_RS02850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
fad_RS02855	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
fad_RS02855	COG3261	NADH dehydrogenase
fad_RS02860	COG0651	ATP synthesis coupled electron transport
fad_RS02880	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
fad_RS02910	COG0105	UTP biosynthetic process
fad_RS02915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
fad_RS02925	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
fad_RS02935	COG0352	thiamine-phosphate diphosphorylase activity
fad_RS02945	COG0351	phosphomethylpyrimidine kinase
fad_RS02945	COG0352	thiamine-phosphate diphosphorylase activity
fad_RS02950	COG1215	transferase activity, transferring glycosyl groups
fad_RS02960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
fad_RS02995	COG2226	methyltransferase
fad_RS03020	COG1335	isochorismatase
fad_RS03025	COG1648	precorrin-2 dehydrogenase activity
fad_RS03030	COG1960	acyl-CoA dehydrogenase activity
fad_RS03035	COG0252	asparaginase activity
fad_RS03040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
fad_RS03045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
fad_RS03050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
fad_RS03055	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
fad_RS03060	COG0649	NAD binding
fad_RS03065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
fad_RS03070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
fad_RS03075	COG0839	Belongs to the complex I subunit 6 family
fad_RS03085	COG0713	ATP synthesis coupled electron transport
fad_RS03090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
fad_RS03100	COG1007	ATP synthesis coupled electron transport
fad_RS03120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
fad_RS03130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
fad_RS03135	COG0531	amino acid
fad_RS03160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
fad_RS03165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
fad_RS03170	COG0517	IMP dehydrogenase activity
fad_RS03175	COG0308	aminopeptidase N
fad_RS03180	COG0009	L-threonylcarbamoyladenylate synthase
fad_RS03220	COG1201	RNA secondary structure unwinding
fad_RS03235	COG4608	Belongs to the ABC transporter superfamily
fad_RS03240	COG0444	Belongs to the ABC transporter superfamily
fad_RS03245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
fad_RS03250	COG0601	transmembrane transport
fad_RS03290	COG4974	Belongs to the 'phage' integrase family
fad_RS03310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
fad_RS03335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
fad_RS03355	COG0477	Major facilitator Superfamily
fad_RS03390	COG0793	Belongs to the peptidase S41A family
fad_RS03390	COG4946	Tricorn protease homolog
fad_RS03395	COG1072	(Pantothenic acid kinase))
fad_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
fad_RS03425	COG0318	PFAM AMP-dependent synthetase and ligase
fad_RS03440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
fad_RS03445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
fad_RS03460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
fad_RS03480	COG0667	Aldo Keto reductase
fad_RS03500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
fad_RS03500	COG0674	pyruvate-flavodoxin oxidoreductase activity
fad_RS03505	COG1013	pyruvate-flavodoxin oxidoreductase activity
fad_RS03520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
fad_RS03525	COG1053	succinate dehydrogenase
fad_RS03530	COG0039	L-malate dehydrogenase activity
fad_RS03535	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
fad_RS03540	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
fad_RS03555	COG0602	queuosine metabolic process
fad_RS03560	COG0302	gtp cyclohydrolase
fad_RS03565	COG0720	synthase
fad_RS03570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
fad_RS03570	COG3608	succinylglutamate desuccinylase aspartoacylase
fad_RS03575	COG0813	purine-nucleoside phosphorylase activity
fad_RS03585	COG0673	inositol 2-dehydrogenase activity
fad_RS03595	COG1234	tRNA 3'-trailer cleavage
fad_RS03605	COG1250	3-hydroxyacyl-CoA dehydrogenase
fad_RS03625	COG2814	Major facilitator Superfamily
fad_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
fad_RS03670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
fad_RS03680	COG0667	Aldo Keto reductase
fad_RS03715	COG1250	3-hydroxyacyl-CoA dehydrogenase
fad_RS03740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
fad_RS03750	COG0443	Heat shock 70 kDa protein
fad_RS03770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
fad_RS03775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
fad_RS03805	COG0693	protein deglycase activity
fad_RS03810	COG1446	asparaginase
fad_RS03845	COG1489	DNA binding
fad_RS03855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
fad_RS03885	COG0423	glycine-tRNA ligase activity
fad_RS03890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
fad_RS03895	COG1733	regulation of RNA biosynthetic process
fad_RS03915	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
fad_RS03915	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
fad_RS03920	COG0477	Major facilitator Superfamily
fad_RS03935	COG1797	cobyrinic acid a,c-diamide synthase activity
fad_RS03945	COG0477	Major facilitator Superfamily
fad_RS03955	COG2814	Major facilitator Superfamily
fad_RS03960	COG0531	amino acid
fad_RS03965	COG0531	amino acid
fad_RS03995	COG3590	peptidase
fad_RS04010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
fad_RS04015	COG2814	Major facilitator Superfamily
fad_RS04020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
fad_RS04050	COG1794	racemase activity, acting on amino acids and derivatives
fad_RS04060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
fad_RS04070	COG0215	cysteine-tRNA ligase activity
fad_RS04075	COG1335	isochorismatase
fad_RS04090	COG2379	hydroxypyruvate reductase
fad_RS04125	COG0477	Major facilitator Superfamily
fad_RS04145	COG1506	peptidase
fad_RS04145	COG4946	Tricorn protease homolog
fad_RS04145	COG0823	Involved in the tonB-independent uptake of proteins
fad_RS04150	COG0477	Major facilitator Superfamily
fad_RS04230	COG3328	transposase activity
fad_RS04280	COG0438	transferase activity, transferring glycosyl groups
fad_RS04285	COG0463	Glycosyl transferase, family 2
fad_RS04295	COG0297	glycogen (starch) synthase activity
fad_RS04315	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
fad_RS04340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
fad_RS04435	COG0303	'Molybdopterin
fad_RS04460	COG3383	formate dehydrogenase (NAD+) activity
fad_RS04470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
fad_RS04475	COG1215	transferase activity, transferring glycosyl groups
fad_RS04480	COG0438	transferase activity, transferring glycosyl groups
fad_RS04520	COG0531	amino acid
fad_RS04525	COG0393	Putative heavy-metal-binding
fad_RS04570	COG0175	sulfate reduction
fad_RS04585	COG3119	arylsulfatase activity
fad_RS04640	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
fad_RS04645	COG1518	maintenance of DNA repeat elements
fad_RS04735	COG1598	PFAM Uncharacterised protein family UPF0150
fad_RS04775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
fad_RS04780	COG4279	zinc finger
fad_RS04795	COG1373	ATPase (AAA superfamily
fad_RS04820	COG2271	Major facilitator Superfamily
fad_RS04825	COG0183	Belongs to the thiolase family
fad_RS04830	COG0318	PFAM AMP-dependent synthetase and ligase
fad_RS04900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
fad_RS04935	COG0318	PFAM AMP-dependent synthetase and ligase
fad_RS04955	COG1215	transferase activity, transferring glycosyl groups
fad_RS04975	COG0640	Transcriptional regulator
fad_RS05000	COG0444	Belongs to the ABC transporter superfamily
fad_RS05020	COG1312	Catalyzes the dehydration of D-mannonate
fad_RS05025	COG1028	Short-chain dehydrogenase reductase Sdr
fad_RS05035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
fad_RS05040	COG3328	transposase activity
fad_RS05045	COG0667	Aldo Keto reductase
fad_RS05060	COG3833	ABC-type maltose transport systems, permease component
fad_RS05085	COG3387	PFAM Glycoside hydrolase 15-related
fad_RS05100	COG4948	Mandelate Racemase Muconate Lactonizing
fad_RS05130	COG0069	glutamate synthase activity
fad_RS05145	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
fad_RS05150	COG0004	ammonium transporteR
fad_RS05175	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
fad_RS05180	COG1506	peptidase
fad_RS05180	COG0823	Involved in the tonB-independent uptake of proteins
fad_RS05180	COG4946	Tricorn protease homolog
fad_RS05195	COG3590	peptidase
fad_RS05215	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
fad_RS05225	COG3185	4-Hydroxyphenylpyruvate dioxygenase
fad_RS05230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
fad_RS05240	COG1215	transferase activity, transferring glycosyl groups
fad_RS05260	COG1032	radical SAM domain protein
fad_RS05270	COG0531	amino acid
fad_RS05275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
fad_RS05280	COG1454	alcohol dehydrogenase
fad_RS05285	COG1012	belongs to the aldehyde dehydrogenase family
fad_RS05300	COG2943	transferase activity, transferring hexosyl groups
fad_RS05315	COG0644	oxidoreductase
fad_RS05320	COG0028	Belongs to the TPP enzyme family
fad_RS05325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
fad_RS05335	COG1832	CoA-binding protein
fad_RS05355	COG0719	Fe-S assembly protein
fad_RS05370	COG0396	ATPase activity
fad_RS05410	COG0436	Aminotransferase
fad_RS05420	COG0372	Belongs to the citrate synthase family
fad_RS05425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
fad_RS05465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
fad_RS05480	COG1597	lipid kinase activity
fad_RS05490	COG1454	alcohol dehydrogenase
fad_RS05490	COG1012	belongs to the aldehyde dehydrogenase family
fad_RS05495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
fad_RS05505	COG2814	Major facilitator Superfamily
fad_RS05520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
fad_RS05535	COG3634	alkyl hydroperoxide reductase activity
fad_RS05555	COG0314	molybdopterin synthase activity
fad_RS05560	COG2814	Major facilitator Superfamily
fad_RS05565	COG0277	FAD linked oxidase domain protein
fad_RS05570	COG2181	nitrate reductase activity
fad_RS05570	COG0247	lactate metabolic process
fad_RS05575	COG0527	aspartate kinase activity
fad_RS05595	COG0560	Phosphoserine phosphatase
fad_RS05600	COG0442	prolyl-tRNA aminoacylation
fad_RS05620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
fad_RS05635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
fad_RS05645	COG0405	Gamma-glutamyltransferase
fad_RS05660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
fad_RS05665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
fad_RS05690	COG0505	Belongs to the CarA family
fad_RS05695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
fad_RS05705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
fad_RS05730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
fad_RS05745	COG0372	Belongs to the citrate synthase family
fad_RS05755	COG0318	PFAM AMP-dependent synthetase and ligase
fad_RS05760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
fad_RS05770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
fad_RS05810	COG1131	(ABC) transporter
fad_RS05845	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
fad_RS05850	COG0540	Belongs to the ATCase OTCase family
fad_RS05895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
fad_RS05895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
fad_RS05900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
fad_RS05900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
fad_RS05910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
fad_RS05930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
fad_RS05940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
fad_RS05955	COG0077	Prephenate dehydratase
fad_RS05955	COG1605	Chorismate mutase
fad_RS05975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
fad_RS05995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
fad_RS06000	COG1063	alcohol dehydrogenase
fad_RS06015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
fad_RS06015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
fad_RS06040	COG0446	pyridine nucleotide-disulphide oxidoreductase
fad_RS06055	COG0450	alkyl hydroperoxide reductase
fad_RS06065	COG1321	iron dependent repressor
fad_RS06085	COG0574	Belongs to the PEP-utilizing enzyme family
fad_RS06085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
fad_RS06095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
fad_RS06105	COG1573	uracil-dna glycosylase
fad_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
fad_RS06130	COG0183	Belongs to the thiolase family
fad_RS06150	COG0183	Belongs to the thiolase family
fad_RS06170	COG0028	Belongs to the TPP enzyme family
fad_RS06180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
fad_RS06195	COG0543	2 iron, 2 sulfur cluster binding
fad_RS06200	COG0167	dihydroorotate dehydrogenase activity
fad_RS06215	COG1573	uracil-dna glycosylase
fad_RS06220	COG2271	Major facilitator Superfamily
fad_RS06240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
fad_RS06270	COG1960	acyl-CoA dehydrogenase activity
fad_RS06275	COG0318	PFAM AMP-dependent synthetase and ligase
fad_RS06280	COG2271	Major facilitator Superfamily
fad_RS06305	COG1024	Enoyl-CoA hydratase
fad_RS06305	COG1250	3-hydroxyacyl-CoA dehydrogenase
fad_RS06310	COG2814	Major facilitator Superfamily
fad_RS06340	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
fad_RS06345	COG0531	amino acid
fad_RS06355	COG0538	isocitrate dehydrogenase activity
fad_RS06370	COG0022	dehydrogenase e1 component
fad_RS06385	COG1024	Enoyl-CoA hydratase
fad_RS06395	COG0318	PFAM AMP-dependent synthetase and ligase
fad_RS06410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
fad_RS06415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
fad_RS06425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
fad_RS06465	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
fad_RS06490	COG1078	dGTPase activity
fad_RS06505	COG1074	ATP-dependent DNA helicase activity
fad_RS06515	COG2189	Belongs to the N(4) N(6)-methyltransferase family
fad_RS06540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
fad_RS06550	COG0138	bifunctional purine biosynthesis protein purh
fad_RS06555	COG1796	DNA polymerase
fad_RS06555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
fad_RS06580	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
fad_RS06600	COG2124	cytochrome p450
fad_RS06615	COG0113	porphobilinogen synthase activity
fad_RS06620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
fad_RS06625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
fad_RS06630	COG0586	Pfam SNARE associated Golgi protein
fad_RS06640	COG0406	alpha-ribazole phosphatase activity
fad_RS06645	COG0004	ammonium transporteR
fad_RS06695	COG0484	heat shock protein binding
fad_RS06700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
fad_RS06705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
fad_RS06750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
fad_RS06750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
fad_RS06760	COG0037	tRNA processing
fad_RS06770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
fad_RS06785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
fad_RS06790	COG2271	Major facilitator Superfamily
fad_RS06795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
fad_RS06810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
fad_RS06830	COG1309	transcriptional regulator
fad_RS06865	COG2986	histidine ammonia-lyase
fad_RS06880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
fad_RS06910	COG0778	Nitroreductase
fad_RS06925	COG2814	Major facilitator Superfamily
fad_RS06935	COG1012	belongs to the aldehyde dehydrogenase family
fad_RS06940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
fad_RS06960	COG4948	Mandelate Racemase Muconate Lactonizing
fad_RS06975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
fad_RS06980	COG4948	Mandelate Racemase Muconate Lactonizing
fad_RS06990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
fad_RS07000	COG1058	Belongs to the CinA family
fad_RS07000	COG1546	Belongs to the CinA family
fad_RS07010	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
fad_RS07025	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
fad_RS07045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
fad_RS07080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
fad_RS07090	COG3253	May function as heme-dependent peroxidase
fad_RS07090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
fad_RS07095	COG1054	Belongs to the UPF0176 family
fad_RS07105	COG0589	response to stress
fad_RS07120	COG2271	Major facilitator Superfamily
fad_RS07130	COG0076	glutamate decarboxylase activity
fad_RS07135	COG0140	phosphoribosyl-ATP diphosphatase activity
fad_RS07135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
fad_RS07140	COG0107	imidazoleglycerol-phosphate synthase activity
fad_RS07145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
fad_RS07150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
fad_RS07155	COG0131	Imidazoleglycerol-phosphate dehydratase
fad_RS07165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
fad_RS07170	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
fad_RS07180	COG0657	acetylesterase activity
fad_RS07195	COG1116	anion transmembrane transporter activity
fad_RS07225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
fad_RS07250	COG3383	formate dehydrogenase (NAD+) activity
fad_RS07255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
fad_RS07260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
fad_RS07270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
fad_RS07275	COG3958	Transketolase
fad_RS07280	COG3959	Transketolase, thiamine diphosphate binding domain
fad_RS07305	COG1418	mRNA catabolic process
fad_RS07355	COG0475	glutathione-regulated potassium exporter activity
fad_RS07375	COG1793	dna ligase
fad_RS07410	COG0463	Glycosyl transferase, family 2
fad_RS07415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
fad_RS07420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
fad_RS07440	COG1028	Short-chain dehydrogenase reductase Sdr
fad_RS07455	COG0003	Pfam Anion-transporting ATPase
fad_RS07460	COG0142	geranyltranstransferase activity
fad_RS07470	COG1522	sequence-specific DNA binding
fad_RS07500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
fad_RS07505	COG0492	ferredoxin-NADP+ reductase activity
fad_RS07510	COG0459	protein refolding
fad_RS07515	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
fad_RS07600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
fad_RS07605	COG2814	Major facilitator Superfamily
fad_RS07640	COG1960	acyl-CoA dehydrogenase activity
fad_RS07655	COG1234	tRNA 3'-trailer cleavage
fad_RS07660	COG2271	Major facilitator Superfamily
fad_RS07665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
fad_RS07670	COG1254	Belongs to the acylphosphatase family
fad_RS07690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
fad_RS07695	COG2890	protein-(glutamine-N5) methyltransferase activity
fad_RS07700	COG0419	ATPase involved in DNA repair
fad_RS07750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
fad_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
fad_RS07775	COG0251	oxidation-reduction process
fad_RS07780	COG3616	Alanine racemase, N-terminal domain
fad_RS07790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
fad_RS07825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
fad_RS07830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
fad_RS07835	COG0477	Major facilitator Superfamily
fad_RS07860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
fad_RS07865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
fad_RS07875	COG2814	Major facilitator Superfamily
fad_RS07890	COG1012	belongs to the aldehyde dehydrogenase family
fad_RS07895	COG0469	pyruvate kinase activity
fad_RS07900	COG0018	arginyl-trna synthetase
fad_RS07905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
fad_RS07915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
fad_RS07925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
fad_RS07950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
fad_RS07955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
fad_RS07970	COG0081	regulation of translation
fad_RS07975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
fad_RS07980	COG2045	Belongs to the ComB family
fad_RS08005	COG0492	ferredoxin-NADP+ reductase activity
fad_RS08015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
fad_RS08035	COG0538	isocitrate dehydrogenase activity
fad_RS08045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
fad_RS08090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
fad_RS08110	COG0051	transcription antitermination factor activity, RNA binding
fad_RS08130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
fad_RS08130	COG0116	Belongs to the methyltransferase superfamily
fad_RS08135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
fad_RS08175	COG0644	oxidoreductase
fad_RS08190	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
fad_RS08205	COG1960	acyl-CoA dehydrogenase activity
fad_RS08220	COG3842	ATPase activity
fad_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
fad_RS08280	COG1473	amidohydrolase
fad_RS08285	COG3938	Belongs to the proline racemase family
fad_RS08295	COG4106	trans-aconitate 2-methyltransferase activity
fad_RS08395	COG0450	alkyl hydroperoxide reductase
fad_RS08405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
fad_RS08425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
fad_RS08435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
fad_RS08440	COG3254	rhamnose metabolic process
fad_RS08445	COG1024	Enoyl-CoA hydratase
fad_RS08450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
fad_RS08485	COG2271	Major facilitator Superfamily
fad_RS08490	COG0504	CTP synthase activity
fad_RS08545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
fad_RS08550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
fad_RS08565	COG0644	oxidoreductase
fad_RS08575	COG2814	Major facilitator Superfamily
fad_RS08615	COG0456	acetyltransferase
fad_RS08620	COG0343	queuine tRNA-ribosyltransferase activity
fad_RS08625	COG1063	alcohol dehydrogenase
fad_RS08630	COG1846	Transcriptional regulator
fad_RS08635	COG0477	Major facilitator Superfamily
fad_RS08640	COG3845	ABC transporter
fad_RS08650	COG0477	Major facilitator Superfamily
fad_RS08655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
fad_RS08660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
fad_RS08665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
fad_RS08670	COG0022	dehydrogenase e1 component
fad_RS08685	COG0321	lipoyl(octanoyl) transferase activity
fad_RS08690	COG2096	Adenosyltransferase
fad_RS08705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
fad_RS08745	COG0519	Catalyzes the synthesis of GMP from XMP
fad_RS08745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
fad_RS08765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
fad_RS08780	COG2151	metal-sulfur cluster biosynthetic enzyme
fad_RS08790	COG0585	pseudouridine synthase activity
fad_RS08800	COG0516	GMP reductase activity
fad_RS08800	COG0517	IMP dehydrogenase activity
fad_RS08825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
fad_RS08830	COG0066	3-isopropylmalate dehydratase activity
fad_RS08855	COG0640	Transcriptional regulator
fad_RS08860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
fad_RS08890	COG0528	UMP kinase activity
fad_RS08900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
fad_RS08905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
fad_RS08920	COG0083	homoserine kinase activity
fad_RS08925	COG0626	cystathionine gamma-synthase activity
fad_RS08940	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
fad_RS08945	COG0301	tRNA thio-modification
fad_RS08945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
fad_RS08960	COG4948	Mandelate Racemase Muconate Lactonizing
fad_RS08965	COG1269	ATP hydrolysis coupled proton transport
fad_RS08975	COG1394	ATPase activity, coupled to movement of substances
fad_RS08980	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
fad_RS08985	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
fad_RS09005	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
fad_RS09015	COG1131	(ABC) transporter
fad_RS09025	COG1304	FMN binding
fad_RS09030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
fad_RS09040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
fad_RS09060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
fad_RS09065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
fad_RS09070	COG0066	3-isopropylmalate dehydratase activity
fad_RS09125	COG0165	Argininosuccinate lyase
fad_RS09130	COG0137	argininosuccinate synthase activity
fad_RS09160	COG0450	alkyl hydroperoxide reductase
fad_RS09180	COG0489	protein tyrosine kinase activity
fad_RS09185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
fad_RS09200	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family