locus-tag	class	description
A6C57_RS00175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6C57_RS00260	COG3179	chitinase
A6C57_RS00350	COG0745	RESPONSE REGULATOR receiver
A6C57_RS00480	COG2226	methyltransferase
A6C57_RS00520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6C57_RS00530	COG0793	Belongs to the peptidase S41A family
A6C57_RS00555	COG1595	DNA-templated transcription, initiation
A6C57_RS00590	COG0673	inositol 2-dehydrogenase activity
A6C57_RS00620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6C57_RS00635	COG1196	nuclear chromosome segregation
A6C57_RS00635	COG0741	lytic transglycosylase activity
A6C57_RS00635	COG0739	heme binding
A6C57_RS00645	COG0156	8-amino-7-oxononanoate synthase activity
A6C57_RS00650	COG4948	Mandelate Racemase Muconate Lactonizing
A6C57_RS00670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6C57_RS00675	COG0612	Peptidase, M16
A6C57_RS00685	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6C57_RS00695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6C57_RS00705	COG0205	6-phosphofructokinase activity
A6C57_RS00725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6C57_RS00730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6C57_RS00740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6C57_RS00745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6C57_RS00745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6C57_RS00775	COG0538	isocitrate dehydrogenase activity
A6C57_RS00790	COG1473	amidohydrolase
A6C57_RS00800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6C57_RS00810	COG0012	GTP binding
A6C57_RS00830	COG1960	acyl-CoA dehydrogenase activity
A6C57_RS00855	COG2076	Multidrug Resistance protein
A6C57_RS00870	COG0784	Response regulator, receiver
A6C57_RS00870	COG5002	protein histidine kinase activity
A6C57_RS00870	COG2205	protein histidine kinase activity
A6C57_RS00885	COG0321	lipoyl(octanoyl) transferase activity
A6C57_RS00885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6C57_RS00895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6C57_RS00900	COG0517	IMP dehydrogenase activity
A6C57_RS00900	COG0516	GMP reductase activity
A6C57_RS00925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6C57_RS00935	COG0534	Mate efflux family protein
A6C57_RS00950	COG1607	acyl-coa hydrolase
A6C57_RS00985	COG0776	regulation of translation
A6C57_RS01070	COG1396	sequence-specific DNA binding
A6C57_RS01085	COG3561	AntA/AntB antirepressor
A6C57_RS01250	COG3179	chitinase
A6C57_RS01345	COG4712	double-strand break repair protein
A6C57_RS01370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6C57_RS01380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6C57_RS01385	COG2912	Transglutaminase-like superfamily
A6C57_RS01420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6C57_RS01425	COG0459	protein refolding
A6C57_RS01445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6C57_RS01465	COG1595	DNA-templated transcription, initiation
A6C57_RS01475	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6C57_RS01480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6C57_RS01490	COG3279	Response regulator of the LytR AlgR family
A6C57_RS01520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6C57_RS01530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6C57_RS01555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6C57_RS01580	COG1132	(ABC) transporter
A6C57_RS01640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6C57_RS01645	COG4251	negative regulation of phosphorylation
A6C57_RS01650	COG2027	D-alanyl-D-alanine carboxypeptidase
A6C57_RS01655	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6C57_RS01660	COG0825	malonyl-CoA metabolic process
A6C57_RS01665	COG2318	DinB family
A6C57_RS01680	COG0719	Fe-S assembly protein
A6C57_RS01695	COG3537	Alpha-1,2-mannosidase
A6C57_RS01705	COG1522	sequence-specific DNA binding
A6C57_RS01710	COG0686	Belongs to the AlaDH PNT family
A6C57_RS01735	COG0235	Class ii aldolase
A6C57_RS01745	COG2160	L-arabinose isomerase activity
A6C57_RS01750	COG1069	ribulokinase activity
A6C57_RS01755	COG3507	Belongs to the glycosyl hydrolase 43 family
A6C57_RS01765	COG3507	Belongs to the glycosyl hydrolase 43 family
A6C57_RS01775	COG0702	epimerase
A6C57_RS01780	COG4771	TonB-dependent receptor
A6C57_RS01790	COG1917	Cupin 2, conserved barrel domain protein
A6C57_RS01795	COG0702	epimerase
A6C57_RS01800	COG1629	transport
A6C57_RS01830	COG0415	Belongs to the DNA photolyase family
A6C57_RS01850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6C57_RS01875	COG3876	Protein conserved in bacteria
A6C57_RS01880	COG0363	glucosamine-6-phosphate deaminase activity
A6C57_RS01885	COG0673	inositol 2-dehydrogenase activity
A6C57_RS01890	COG1199	ATP-dependent helicase activity
A6C57_RS01890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6C57_RS01895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6C57_RS01905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6C57_RS01910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6C57_RS01910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6C57_RS01935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6C57_RS01945	COG0667	Aldo Keto reductase
A6C57_RS01960	COG2205	protein histidine kinase activity
A6C57_RS01980	COG1858	cytochrome C peroxidase
A6C57_RS01990	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6C57_RS01995	COG0758	DNA mediated transformation
A6C57_RS01995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6C57_RS02000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6C57_RS02005	COG1278	Cold shock
A6C57_RS02035	COG2814	Major facilitator Superfamily
A6C57_RS02050	COG1214	PFAM Peptidase M22, glycoprotease
A6C57_RS02055	COG0793	Belongs to the peptidase S41A family
A6C57_RS02060	COG0594	ribonuclease P activity
A6C57_RS02080	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6C57_RS02120	COG3250	beta-galactosidase activity
A6C57_RS02125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6C57_RS02155	COG1070	Carbohydrate kinase
A6C57_RS02175	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6C57_RS02185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6C57_RS02190	COG0346	lactoylglutathione lyase activity
A6C57_RS02205	COG1253	flavin adenine dinucleotide binding
A6C57_RS02260	COG1187	pseudouridine synthase activity
A6C57_RS02265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6C57_RS02265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6C57_RS02270	COG0335	large ribosomal subunit rRNA binding
A6C57_RS02275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6C57_RS02280	COG3781	membrane
A6C57_RS02285	COG1054	Belongs to the UPF0176 family
A6C57_RS02290	COG1629	transport
A6C57_RS02290	COG4206	TonB-dependent receptor
A6C57_RS02310	COG4771	TonB-dependent receptor
A6C57_RS02345	COG2267	carboxylic ester hydrolase activity
A6C57_RS02355	COG0531	amino acid
A6C57_RS02370	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6C57_RS02375	COG4181	ATPase activity
A6C57_RS02390	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6C57_RS02395	COG0739	heme binding
A6C57_RS02400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6C57_RS02405	COG3959	Transketolase, thiamine diphosphate binding domain
A6C57_RS02410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6C57_RS02420	COG3958	Transketolase
A6C57_RS02425	COG1595	DNA-templated transcription, initiation
A6C57_RS02445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6C57_RS02465	COG1629	transport
A6C57_RS02470	COG1104	cysteine desulfurase activity
A6C57_RS02475	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A6C57_RS02500	COG3142	Participates in the control of copper homeostasis
A6C57_RS02510	COG1136	(ABC) transporter
A6C57_RS02515	COG0346	lactoylglutathione lyase activity
A6C57_RS02520	COG0316	Belongs to the HesB IscA family
A6C57_RS02565	COG2205	protein histidine kinase activity
A6C57_RS02575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A6C57_RS02585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A6C57_RS02595	COG3158	transport of potassium into the cell
A6C57_RS02615	COG0024	Methionine aminopeptidase
A6C57_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS02650	COG1629	transport
A6C57_RS02690	COG2239	Acts as a magnesium transporter
A6C57_RS02710	COG0393	Putative heavy-metal-binding
A6C57_RS02740	COG2814	Major facilitator Superfamily
A6C57_RS02770	COG0673	inositol 2-dehydrogenase activity
A6C57_RS02780	COG2197	response regulator
A6C57_RS02810	COG1196	nuclear chromosome segregation
A6C57_RS02810	COG0741	lytic transglycosylase activity
A6C57_RS02810	COG0739	heme binding
A6C57_RS02835	COG0673	inositol 2-dehydrogenase activity
A6C57_RS02840	COG0673	inositol 2-dehydrogenase activity
A6C57_RS02870	COG0420	3'-5' exonuclease activity
A6C57_RS02875	COG0419	ATPase involved in DNA repair
A6C57_RS02880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6C57_RS02895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6C57_RS02895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6C57_RS02900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6C57_RS02935	COG0318	PFAM AMP-dependent synthetase and ligase
A6C57_RS02960	COG2972	Histidine kinase
A6C57_RS02985	COG3118	belongs to the thioredoxin family
A6C57_RS03000	COG0326	Molecular chaperone. Has ATPase activity
A6C57_RS03005	COG3942	CHAP domain
A6C57_RS03005	COG1388	LysM domain
A6C57_RS03010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6C57_RS03045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6C57_RS03055	COG0793	Belongs to the peptidase S41A family
A6C57_RS03065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6C57_RS03090	COG0126	phosphoglycerate kinase activity
A6C57_RS03125	COG2226	methyltransferase
A6C57_RS03145	COG4771	TonB-dependent receptor
A6C57_RS03170	COG1381	Involved in DNA repair and RecF pathway recombination
A6C57_RS03180	COG1137	ATPase activity
A6C57_RS03185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6C57_RS03185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6C57_RS03215	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A6C57_RS03225	COG1506	peptidase
A6C57_RS03225	COG4946	Tricorn protease homolog
A6C57_RS03225	COG0823	Involved in the tonB-independent uptake of proteins
A6C57_RS03225	COG0823	Involved in the tonB-independent uptake of proteins
A6C57_RS03225	COG1506	peptidase
A6C57_RS03225	COG4946	Tricorn protease homolog
A6C57_RS03230	COG1858	cytochrome C peroxidase
A6C57_RS03240	COG0318	PFAM AMP-dependent synthetase and ligase
A6C57_RS03265	COG1011	Hydrolase
A6C57_RS03280	COG0616	signal peptide processing
A6C57_RS03285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6C57_RS03290	COG0463	Glycosyl transferase, family 2
A6C57_RS03295	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6C57_RS03305	COG1703	isobutyryl-CoA mutase activity
A6C57_RS03305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6C57_RS03305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6C57_RS03335	COG1649	PFAM Uncharacterised BCR, COG1649
A6C57_RS03340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6C57_RS03345	COG1119	ATPase activity
A6C57_RS03355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6C57_RS03360	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A6C57_RS03365	COG0300	oxidoreductase activity
A6C57_RS03390	COG3118	belongs to the thioredoxin family
A6C57_RS03395	COG3258	Cytochrome c
A6C57_RS03410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6C57_RS03410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6C57_RS03415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6C57_RS03435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6C57_RS03445	COG1295	ribonuclease BN
A6C57_RS03450	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS03455	COG0009	L-threonylcarbamoyladenylate synthase
A6C57_RS03475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6C57_RS03480	COG0784	Response regulator, receiver
A6C57_RS03520	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6C57_RS03530	COG0745	RESPONSE REGULATOR receiver
A6C57_RS03535	COG3852	Histidine kinase
A6C57_RS03540	COG3852	Histidine kinase
A6C57_RS03550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6C57_RS03555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6C57_RS03580	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS03605	COG0415	Belongs to the DNA photolyase family
A6C57_RS03630	COG1629	transport
A6C57_RS03630	COG4206	TonB-dependent receptor
A6C57_RS03640	COG0561	phosphatase activity
A6C57_RS03645	COG4771	TonB-dependent receptor
A6C57_RS03655	COG1629	transport
A6C57_RS03680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6C57_RS03685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6C57_RS03695	COG2207	Transcriptional regulator
A6C57_RS03695	COG1917	Cupin 2, conserved barrel domain protein
A6C57_RS03700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6C57_RS03705	COG0085	RNA polymerase activity
A6C57_RS03710	COG0222	ribosome binding
A6C57_RS03715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6C57_RS03720	COG0081	regulation of translation
A6C57_RS03725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6C57_RS03790	COG2322	membrane
A6C57_RS03795	COG1999	signal sequence binding
A6C57_RS03805	COG1845	cytochrome c oxidase, subunit III
A6C57_RS03815	COG0109	protoheme IX farnesyltransferase activity
A6C57_RS03825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6C57_RS03855	COG0437	4 iron, 4 sulfur cluster binding
A6C57_RS03880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6C57_RS03915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6C57_RS03930	COG0513	Belongs to the DEAD box helicase family
A6C57_RS03945	COG1132	(ABC) transporter
A6C57_RS03955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6C57_RS03965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6C57_RS03970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6C57_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS03975	COG3321	synthase
A6C57_RS03975	COG0604	alcohol dehydrogenase
A6C57_RS03980	COG2204	response regulator
A6C57_RS04005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6C57_RS04020	COG4251	negative regulation of phosphorylation
A6C57_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS04035	COG5183	chlorophyll binding
A6C57_RS04035	COG2133	pyrroloquinoline quinone binding
A6C57_RS04055	COG0577	efflux transmembrane transporter activity
A6C57_RS04055	COG1136	(ABC) transporter
A6C57_RS04095	COG0577	efflux transmembrane transporter activity
A6C57_RS04105	COG0577	efflux transmembrane transporter activity
A6C57_RS04115	COG0577	efflux transmembrane transporter activity
A6C57_RS04120	COG0577	efflux transmembrane transporter activity
A6C57_RS04120	COG1136	(ABC) transporter
A6C57_RS04140	COG0577	efflux transmembrane transporter activity
A6C57_RS04145	COG0577	efflux transmembrane transporter activity
A6C57_RS04145	COG1136	(ABC) transporter
A6C57_RS04150	COG1136	(ABC) transporter
A6C57_RS04150	COG0577	efflux transmembrane transporter activity
A6C57_RS04160	COG0577	efflux transmembrane transporter activity
A6C57_RS04165	COG2321	neutral zinc metallopeptidase
A6C57_RS04170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6C57_RS04185	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6C57_RS04215	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A6C57_RS04260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6C57_RS04265	COG1136	(ABC) transporter
A6C57_RS04265	COG0577	efflux transmembrane transporter activity
A6C57_RS04290	COG0149	triose-phosphate isomerase activity
A6C57_RS04300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6C57_RS04305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6C57_RS04315	COG5183	chlorophyll binding
A6C57_RS04315	COG2133	pyrroloquinoline quinone binding
A6C57_RS04325	COG0745	RESPONSE REGULATOR receiver
A6C57_RS04330	COG0784	Response regulator, receiver
A6C57_RS04340	COG0489	protein tyrosine kinase activity
A6C57_RS04350	COG2244	polysaccharide biosynthetic process
A6C57_RS04360	COG1216	Glycosyl transferase, family 2
A6C57_RS04370	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS04380	COG0463	Glycosyl transferase, family 2
A6C57_RS04420	COG0805	protein transport
A6C57_RS04425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6C57_RS04430	COG0049	tRNA binding
A6C57_RS04435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6C57_RS04440	COG3590	peptidase
A6C57_RS04450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6C57_RS04460	COG1595	DNA-templated transcription, initiation
A6C57_RS04495	COG0339	signal peptide processing
A6C57_RS04520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6C57_RS04525	COG0358	DNA primase activity
A6C57_RS04530	COG3250	beta-galactosidase activity
A6C57_RS04540	COG4628	conserved protein (DUF2132)
A6C57_RS04575	COG2706	6-phosphogluconolactonase activity
A6C57_RS04590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6C57_RS04610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A6C57_RS04625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6C57_RS04650	COG2130	NADP-dependent
A6C57_RS04655	COG1764	response to oxidative stress
A6C57_RS04660	COG1846	Transcriptional regulator
A6C57_RS04680	COG1401	restriction endodeoxyribonuclease activity
A6C57_RS04695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6C57_RS04710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6C57_RS04715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6C57_RS04720	COG2205	protein histidine kinase activity
A6C57_RS04720	COG3292	Two component regulator propeller
A6C57_RS04720	COG0745	RESPONSE REGULATOR receiver
A6C57_RS04725	COG0688	phosphatidylethanolamine metabolic process
A6C57_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS04750	COG0531	amino acid
A6C57_RS04765	COG1694	Mazg nucleotide pyrophosphohydrolase
A6C57_RS04770	COG0612	Peptidase, M16
A6C57_RS04785	COG1252	NADH dehydrogenase
A6C57_RS04790	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS04825	COG2610	gluconate transmembrane transporter activity
A6C57_RS04885	COG2205	protein histidine kinase activity
A6C57_RS04890	COG0745	RESPONSE REGULATOR receiver
A6C57_RS04935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6C57_RS04940	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6C57_RS04960	COG0737	Belongs to the 5'-nucleotidase family
A6C57_RS04965	COG0047	phosphoribosylformylglycinamidine synthase activity
A6C57_RS04970	COG0443	Heat shock 70 kDa protein
A6C57_RS04975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6C57_RS04990	COG0488	(ABC) transporter
A6C57_RS05010	COG4251	negative regulation of phosphorylation
A6C57_RS05020	COG2197	response regulator
A6C57_RS05025	COG4251	negative regulation of phosphorylation
A6C57_RS05040	COG0156	8-amino-7-oxononanoate synthase activity
A6C57_RS05045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6C57_RS05060	COG1472	Belongs to the glycosyl hydrolase 3 family
A6C57_RS05065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6C57_RS05070	COG0105	UTP biosynthetic process
A6C57_RS05075	COG0405	Gamma-glutamyltransferase
A6C57_RS05085	COG3485	protocatechuate 3,4-dioxygenase
A6C57_RS05100	COG1981	membrane
A6C57_RS05105	COG1136	(ABC) transporter
A6C57_RS05110	COG1136	(ABC) transporter
A6C57_RS05110	COG0577	efflux transmembrane transporter activity
A6C57_RS05115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6C57_RS05125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6C57_RS05130	COG2217	Heavy metal translocating P-type atpase
A6C57_RS05135	COG0693	protein deglycase activity
A6C57_RS05135	COG0753	catalase activity
A6C57_RS05150	COG1393	Belongs to the ArsC family
A6C57_RS05155	COG1629	transport
A6C57_RS05175	COG4948	Mandelate Racemase Muconate Lactonizing
A6C57_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS05190	COG2271	Major facilitator Superfamily
A6C57_RS05205	COG0667	Aldo Keto reductase
A6C57_RS05270	COG4447	cellulose binding
A6C57_RS05275	COG4702	Belongs to the UPF0303 family
A6C57_RS05285	COG4251	negative regulation of phosphorylation
A6C57_RS05290	COG4251	negative regulation of phosphorylation
A6C57_RS05295	COG1741	Belongs to the pirin family
A6C57_RS05300	COG4702	Belongs to the UPF0303 family
A6C57_RS05305	COG2072	flavoprotein involved in K transport
A6C57_RS05335	COG0702	epimerase
A6C57_RS05340	COG1629	transport
A6C57_RS05345	COG0702	epimerase
A6C57_RS05365	COG3292	Two component regulator propeller
A6C57_RS05365	COG0745	RESPONSE REGULATOR receiver
A6C57_RS05365	COG2205	protein histidine kinase activity
A6C57_RS05365	COG0745	RESPONSE REGULATOR receiver
A6C57_RS05365	COG3292	Two component regulator propeller
A6C57_RS05365	COG2205	protein histidine kinase activity
A6C57_RS05400	COG3279	Response regulator of the LytR AlgR family
A6C57_RS05405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6C57_RS05415	COG0589	response to stress
A6C57_RS05440	COG2989	Protein conserved in bacteria
A6C57_RS05465	COG0589	response to stress
A6C57_RS05480	COG0604	alcohol dehydrogenase
A6C57_RS05485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6C57_RS05495	COG2226	methyltransferase
A6C57_RS05495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6C57_RS05495	COG0596	Alpha beta hydrolase
A6C57_RS05500	COG1297	OPT oligopeptide transporter protein
A6C57_RS05510	COG1595	DNA-templated transcription, initiation
A6C57_RS05525	COG0284	orotidine-5'-phosphate decarboxylase activity
A6C57_RS05565	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A6C57_RS05570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6C57_RS05595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6C57_RS05600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6C57_RS05610	COG2096	Adenosyltransferase
A6C57_RS05620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6C57_RS05630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6C57_RS05650	COG1064	alcohol dehydrogenase
A6C57_RS05705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6C57_RS05735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6C57_RS05745	COG0492	ferredoxin-NADP+ reductase activity
A6C57_RS05750	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6C57_RS05750	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6C57_RS05770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6C57_RS05780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6C57_RS05785	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS05790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6C57_RS05795	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6C57_RS05805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6C57_RS05810	COG1940	carbohydrate kinase activity
A6C57_RS05815	COG1695	Transcriptional regulator
A6C57_RS05840	COG0113	porphobilinogen synthase activity
A6C57_RS05845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6C57_RS05850	COG1950	PFAM Membrane protein of
A6C57_RS05855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6C57_RS05855	COG0140	phosphoribosyl-ATP diphosphatase activity
A6C57_RS05860	COG0107	imidazoleglycerol-phosphate synthase activity
A6C57_RS05870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6C57_RS05900	COG1216	Glycosyl transferase, family 2
A6C57_RS05910	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS05915	COG2244	polysaccharide biosynthetic process
A6C57_RS05920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6C57_RS05950	COG0297	glycogen (starch) synthase activity
A6C57_RS05965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6C57_RS05970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6C57_RS05975	COG0657	acetylesterase activity
A6C57_RS05975	COG2755	lipolytic protein G-D-S-L family
A6C57_RS05990	COG0022	dehydrogenase e1 component
A6C57_RS06015	COG3119	arylsulfatase activity
A6C57_RS06020	COG1086	Polysaccharide biosynthesis protein
A6C57_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS06035	COG1774	PSP1 C-terminal conserved region
A6C57_RS06040	COG0151	Belongs to the GarS family
A6C57_RS06045	COG0514	ATP-dependent DNA helicase (RecQ)
A6C57_RS06050	COG0517	IMP dehydrogenase activity
A6C57_RS06050	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6C57_RS06065	COG0251	oxidation-reduction process
A6C57_RS06070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6C57_RS06070	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6C57_RS06080	COG0612	Peptidase, M16
A6C57_RS06085	COG5183	chlorophyll binding
A6C57_RS06085	COG2133	pyrroloquinoline quinone binding
A6C57_RS06105	COG1335	isochorismatase
A6C57_RS06110	COG0700	Nucleoside recognition
A6C57_RS06125	COG2755	lipolytic protein G-D-S-L family
A6C57_RS06125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6C57_RS06145	COG0247	lactate metabolic process
A6C57_RS06145	COG2181	nitrate reductase activity
A6C57_RS06150	COG0247	lactate metabolic process
A6C57_RS06150	COG2181	nitrate reductase activity
A6C57_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS06190	COG1217	gtp-binding protein TYPA
A6C57_RS06235	COG1678	Uncharacterized ACR, COG1678
A6C57_RS06245	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6C57_RS06255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6C57_RS06260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6C57_RS06265	COG2353	YceI-like domain
A6C57_RS06295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6C57_RS06310	COG3781	membrane
A6C57_RS06325	COG4771	TonB-dependent receptor
A6C57_RS06345	COG1956	GAF domain-containing protein
A6C57_RS06360	COG1024	Enoyl-CoA hydratase
A6C57_RS06360	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6C57_RS06365	COG0183	Belongs to the thiolase family
A6C57_RS06380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6C57_RS06415	COG3186	Phenylalanine-4-hydroxylase
A6C57_RS06420	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A6C57_RS06430	COG2255	four-way junction helicase activity
A6C57_RS06445	COG1160	GTP binding
A6C57_RS06450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6C57_RS06460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6C57_RS06470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6C57_RS06480	COG0552	protein localization to endoplasmic reticulum
A6C57_RS06495	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6C57_RS06500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6C57_RS06510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6C57_RS06530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6C57_RS06535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6C57_RS06540	COG0052	Belongs to the universal ribosomal protein uS2 family
A6C57_RS06545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6C57_RS06560	COG0668	transmembrane transport
A6C57_RS06570	COG1970	mechanosensitive ion channel activity
A6C57_RS06575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6C57_RS06580	COG0772	Belongs to the SEDS family
A6C57_RS06585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6C57_RS06590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6C57_RS06605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6C57_RS06615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6C57_RS06620	COG0535	radical SAM domain protein
A6C57_RS06640	COG4585	Histidine kinase
A6C57_RS06655	COG0156	8-amino-7-oxononanoate synthase activity
A6C57_RS06680	COG1595	DNA-templated transcription, initiation
A6C57_RS06690	COG0194	GDP metabolic process
A6C57_RS06695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6C57_RS06705	COG2234	aminopeptidase activity
A6C57_RS06715	COG0215	cysteine-tRNA ligase activity
A6C57_RS06730	COG1629	transport
A6C57_RS06735	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6C57_RS06740	COG4771	TonB-dependent receptor
A6C57_RS06755	COG4191	Histidine kinase
A6C57_RS06760	COG0673	inositol 2-dehydrogenase activity
A6C57_RS06765	COG2204	response regulator
A6C57_RS06785	COG1136	(ABC) transporter
A6C57_RS06800	COG0673	inositol 2-dehydrogenase activity
A6C57_RS06805	COG1404	Belongs to the peptidase S8 family
A6C57_RS06830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6C57_RS06840	COG0473	3-isopropylmalate dehydrogenase activity
A6C57_RS06850	COG0066	3-isopropylmalate dehydratase activity
A6C57_RS06855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6C57_RS06875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6C57_RS06880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6C57_RS06895	COG0028	Belongs to the TPP enzyme family
A6C57_RS06900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6C57_RS06905	COG0129	dihydroxy-acid dehydratase activity
A6C57_RS06935	COG2326	polyphosphate kinase activity
A6C57_RS06945	COG2326	polyphosphate kinase activity
A6C57_RS06965	COG2856	Zn peptidase
A6C57_RS07075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6C57_RS07080	COG1595	DNA-templated transcription, initiation
A6C57_RS07090	COG4251	negative regulation of phosphorylation
A6C57_RS07110	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A6C57_RS07110	COG0662	Cupin 2, conserved barrel domain protein
A6C57_RS07115	COG4771	TonB-dependent receptor
A6C57_RS07125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6C57_RS07135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6C57_RS07145	COG1960	acyl-CoA dehydrogenase activity
A6C57_RS07160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6C57_RS07190	COG1053	succinate dehydrogenase
A6C57_RS07195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6C57_RS07230	COG1278	Cold shock
A6C57_RS07245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6C57_RS07245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6C57_RS07250	COG0254	rRNA binding
A6C57_RS07265	COG0525	valine-tRNA ligase activity
A6C57_RS07270	COG2353	YceI-like domain
A6C57_RS07290	COG0275	rRNA processing
A6C57_RS07300	COG0768	penicillin binding
A6C57_RS07325	COG0754	glutathionylspermidine amidase activity
A6C57_RS07335	COG0366	Alpha amylase catalytic
A6C57_RS07340	COG4771	TonB-dependent receptor
A6C57_RS07345	COG4771	TonB-dependent receptor
A6C57_RS07380	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS07395	COG2244	polysaccharide biosynthetic process
A6C57_RS07400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6C57_RS07420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6C57_RS07430	COG0612	Peptidase, M16
A6C57_RS07435	COG1629	transport
A6C57_RS07445	COG0698	ribose 5-phosphate isomerase
A6C57_RS07450	COG1960	acyl-CoA dehydrogenase activity
A6C57_RS07465	COG2610	gluconate transmembrane transporter activity
A6C57_RS07485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6C57_RS07515	COG4302	ethanolamine ammonia-lyase activity
A6C57_RS07525	COG4303	Ethanolamine ammonia lyase large subunit
A6C57_RS07530	COG4269	membrane
A6C57_RS07535	COG0501	Belongs to the peptidase M48B family
A6C57_RS07540	COG0531	amino acid
A6C57_RS07545	COG0501	Belongs to the peptidase M48B family
A6C57_RS07550	COG1960	acyl-CoA dehydrogenase activity
A6C57_RS07560	COG1959	2 iron, 2 sulfur cluster binding
A6C57_RS07565	COG1629	transport
A6C57_RS07570	COG0702	epimerase
A6C57_RS07585	COG2373	Large extracellular alpha-helical protein
A6C57_RS07615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6C57_RS07625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6C57_RS07640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6C57_RS07650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6C57_RS07675	COG0633	Ferredoxin
A6C57_RS07685	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS07695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6C57_RS07695	COG0426	domain, Protein
A6C57_RS07710	COG0584	glycerophosphoryl diester phosphodiesterase
A6C57_RS07715	COG0159	tryptophan synthase activity
A6C57_RS07720	COG0133	tryptophan synthase activity
A6C57_RS07725	COG0135	phosphoribosylanthranilate isomerase activity
A6C57_RS07730	COG0134	indole-3-glycerol-phosphate synthase activity
A6C57_RS07735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6C57_RS07745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6C57_RS07755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6C57_RS07785	COG1012	belongs to the aldehyde dehydrogenase family
A6C57_RS07790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6C57_RS07810	COG0445	tRNA wobble uridine modification
A6C57_RS07825	COG1040	competence protein
A6C57_RS07830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6C57_RS07835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6C57_RS07860	COG0346	lactoylglutathione lyase activity
A6C57_RS07865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6C57_RS07870	COG1127	ABC transporter
A6C57_RS07880	COG0606	chelatase, subunit chli
A6C57_RS07905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6C57_RS07910	COG0514	ATP-dependent DNA helicase (RecQ)
A6C57_RS07930	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6C57_RS07930	COG1024	Enoyl-CoA hydratase
A6C57_RS07960	COG0673	inositol 2-dehydrogenase activity
A6C57_RS07970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6C57_RS07980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6C57_RS07995	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS08015	COG1321	iron dependent repressor
A6C57_RS08015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6C57_RS08020	COG1914	H( )-stimulated, divalent metal cation uptake system
A6C57_RS08025	COG4251	negative regulation of phosphorylation
A6C57_RS08040	COG1228	amidohydrolase
A6C57_RS08050	COG0242	peptide deformylase activity
A6C57_RS08055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6C57_RS08075	COG0210	DNA helicase
A6C57_RS08090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6C57_RS08120	COG1131	(ABC) transporter
A6C57_RS08140	COG1388	LysM domain
A6C57_RS08140	COG4932	domain protein
A6C57_RS08145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6C57_RS08150	COG0456	acetyltransferase
A6C57_RS08155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6C57_RS08160	COG0513	Belongs to the DEAD box helicase family
A6C57_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS08175	COG1214	PFAM Peptidase M22, glycoprotease
A6C57_RS08175	COG0456	acetyltransferase
A6C57_RS08190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6C57_RS08200	COG1610	YqeY-like protein
A6C57_RS08230	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A6C57_RS08255	COG0494	nUDIX hydrolase
A6C57_RS08260	COG1611	Belongs to the LOG family
A6C57_RS08265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6C57_RS08270	COG3047	cAMP biosynthetic process
A6C57_RS08270	COG2885	chlorophyll binding
A6C57_RS08295	COG1914	H( )-stimulated, divalent metal cation uptake system
A6C57_RS08350	COG2885	chlorophyll binding
A6C57_RS08365	COG0667	Aldo Keto reductase
A6C57_RS08425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6C57_RS08430	COG0579	oxidoreductase
A6C57_RS08435	COG4935	Belongs to the peptidase S8 family
A6C57_RS08435	COG2234	aminopeptidase activity
A6C57_RS08440	COG4953	penicillin-binding protein 1C
A6C57_RS08445	COG1408	metallophosphoesterase
A6C57_RS08460	COG2267	carboxylic ester hydrolase activity
A6C57_RS08470	COG2115	Belongs to the xylose isomerase family
A6C57_RS08480	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6C57_RS08485	COG0297	glycogen (starch) synthase activity
A6C57_RS08495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6C57_RS08515	COG3001	Fructosamine kinase
A6C57_RS08540	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6C57_RS08550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6C57_RS08615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6C57_RS08665	COG0527	aspartate kinase activity
A6C57_RS08675	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A6C57_RS08690	COG1595	DNA-templated transcription, initiation
A6C57_RS08705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6C57_RS08720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6C57_RS08720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6C57_RS08725	COG0277	FAD linked oxidase domain protein
A6C57_RS08740	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A6C57_RS08770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6C57_RS08815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6C57_RS08825	COG0321	lipoyl(octanoyl) transferase activity
A6C57_RS08835	COG0557	exoribonuclease II activity
A6C57_RS08845	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A6C57_RS08850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6C57_RS08870	COG1515	deoxyribonuclease V activity
A6C57_RS08875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6C57_RS08880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6C57_RS08885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6C57_RS08900	COG0181	hydroxymethylbilane synthase activity
A6C57_RS08915	COG0138	bifunctional purine biosynthesis protein purh
A6C57_RS08925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6C57_RS08935	COG0488	(ABC) transporter
A6C57_RS08940	COG0586	Pfam SNARE associated Golgi protein
A6C57_RS08950	COG1505	serine-type exopeptidase activity
A6C57_RS08975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6C57_RS08980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6C57_RS08985	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A6C57_RS08990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6C57_RS09005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6C57_RS09010	COG0183	Belongs to the thiolase family
A6C57_RS09015	COG0839	Belongs to the complex I subunit 6 family
A6C57_RS09020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6C57_RS09025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6C57_RS09030	COG1034	ATP synthesis coupled electron transport
A6C57_RS09060	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6C57_RS09065	COG0649	NAD binding
A6C57_RS09070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6C57_RS09075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6C57_RS09080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6C57_RS09095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6C57_RS09100	COG0563	adenylate kinase activity
A6C57_RS09135	COG0811	peptide transport
A6C57_RS09155	COG1309	transcriptional regulator
A6C57_RS09170	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6C57_RS09205	COG1007	ATP synthesis coupled electron transport
A6C57_RS09210	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6C57_RS09215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6C57_RS09220	COG0713	ATP synthesis coupled electron transport
A6C57_RS09230	COG2137	regulation of response to DNA damage stimulus
A6C57_RS09240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6C57_RS09250	COG1739	Uncharacterized protein family UPF0029
A6C57_RS09255	COG1132	(ABC) transporter
A6C57_RS09260	COG0300	oxidoreductase activity
A6C57_RS09265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6C57_RS09270	COG1127	ABC transporter
A6C57_RS09285	COG0247	lactate metabolic process
A6C57_RS09285	COG0277	FAD linked oxidase domain protein
A6C57_RS09290	COG4771	TonB-dependent receptor
A6C57_RS09310	COG4771	TonB-dependent receptor
A6C57_RS09315	COG0702	epimerase
A6C57_RS09340	COG0702	epimerase
A6C57_RS09345	COG4771	TonB-dependent receptor
A6C57_RS09365	COG1621	beta-fructofuranosidase activity
A6C57_RS09370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6C57_RS09370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6C57_RS09375	COG2814	Major facilitator Superfamily
A6C57_RS09380	COG1082	Xylose isomerase domain protein TIM barrel
A6C57_RS09385	COG2205	protein histidine kinase activity
A6C57_RS09385	COG3292	Two component regulator propeller
A6C57_RS09385	COG0745	RESPONSE REGULATOR receiver
A6C57_RS09390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6C57_RS09415	COG1132	(ABC) transporter
A6C57_RS09435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6C57_RS09440	COG0251	oxidation-reduction process
A6C57_RS09445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6C57_RS09460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6C57_RS09505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6C57_RS09520	COG0653	protein targeting
A6C57_RS09535	COG2226	methyltransferase
A6C57_RS09545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6C57_RS09555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6C57_RS09565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6C57_RS09595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6C57_RS09610	COG0306	phosphate transporter
A6C57_RS09615	COG0306	phosphate transporter
A6C57_RS09635	COG2382	esterase
A6C57_RS09635	COG3507	Belongs to the glycosyl hydrolase 43 family
A6C57_RS09635	COG3693	PFAM glycoside hydrolase, family 10
A6C57_RS09640	COG2382	esterase
A6C57_RS09645	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A6C57_RS09650	COG2382	esterase
A6C57_RS09650	COG3693	PFAM glycoside hydrolase, family 10
A6C57_RS09655	COG3693	PFAM glycoside hydrolase, family 10
A6C57_RS09655	COG2382	esterase
A6C57_RS09655	COG3507	Belongs to the glycosyl hydrolase 43 family
A6C57_RS09660	COG2382	esterase
A6C57_RS09665	COG2382	esterase
A6C57_RS09665	COG3693	PFAM glycoside hydrolase, family 10
A6C57_RS09670	COG0657	acetylesterase activity
A6C57_RS09670	COG2755	lipolytic protein G-D-S-L family
A6C57_RS09675	COG2382	esterase
A6C57_RS09680	COG3507	Belongs to the glycosyl hydrolase 43 family
A6C57_RS09685	COG5520	Belongs to the glycosyl hydrolase 30 family
A6C57_RS09695	COG3507	Belongs to the glycosyl hydrolase 43 family
A6C57_RS09715	COG0745	RESPONSE REGULATOR receiver
A6C57_RS09715	COG2205	protein histidine kinase activity
A6C57_RS09715	COG3292	Two component regulator propeller
A6C57_RS09730	COG0702	epimerase
A6C57_RS09745	COG4771	TonB-dependent receptor
A6C57_RS09760	COG4771	TonB-dependent receptor
A6C57_RS09780	COG4771	TonB-dependent receptor
A6C57_RS09810	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6C57_RS09815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6C57_RS09820	COG4770	biotin carboxylase activity
A6C57_RS09825	COG0823	Involved in the tonB-independent uptake of proteins
A6C57_RS09825	COG1506	peptidase
A6C57_RS09855	COG0556	nucleotide-excision repair
A6C57_RS09865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6C57_RS09885	COG0051	transcription antitermination factor activity, RNA binding
A6C57_RS09890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6C57_RS09895	COG2207	Transcriptional regulator
A6C57_RS09895	COG0662	Cupin 2, conserved barrel domain protein
A6C57_RS09920	COG2814	Major facilitator Superfamily
A6C57_RS09930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A6C57_RS09935	COG0604	alcohol dehydrogenase
A6C57_RS09935	COG3321	synthase
A6C57_RS09935	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS09945	COG2207	Transcriptional regulator
A6C57_RS09955	COG0366	Alpha amylase catalytic
A6C57_RS09970	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6C57_RS09970	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6C57_RS09980	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A6C57_RS09995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6C57_RS10020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6C57_RS10025	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6C57_RS10035	COG0531	amino acid
A6C57_RS10050	COG1629	transport
A6C57_RS10090	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS10110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6C57_RS10115	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6C57_RS10145	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS10150	COG1960	acyl-CoA dehydrogenase activity
A6C57_RS10185	COG0463	Glycosyl transferase, family 2
A6C57_RS10190	COG0367	asparagine synthase
A6C57_RS10230	COG1770	oligopeptidase
A6C57_RS10245	COG4585	Histidine kinase
A6C57_RS10250	COG0649	NAD binding
A6C57_RS10270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6C57_RS10275	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6C57_RS10295	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A6C57_RS10305	COG1595	DNA-templated transcription, initiation
A6C57_RS10335	COG0531	amino acid
A6C57_RS10340	COG1131	(ABC) transporter
A6C57_RS10355	COG0705	Rhomboid family
A6C57_RS10355	COG0457	Tetratricopeptide repeat
A6C57_RS10375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6C57_RS10380	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
A6C57_RS10390	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6C57_RS10400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6C57_RS10405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6C57_RS10420	COG1090	epimerase
A6C57_RS10430	COG0470	DNA polymerase III
A6C57_RS10435	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS10445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6C57_RS10460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6C57_RS10485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6C57_RS10490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6C57_RS10495	COG2072	flavoprotein involved in K transport
A6C57_RS10510	COG4152	abc transporter atp-binding protein
A6C57_RS10515	COG1668	transmembrane transport
A6C57_RS10520	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6C57_RS10525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6C57_RS10535	COG0483	inositol monophosphate 1-phosphatase activity
A6C57_RS10540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6C57_RS10550	COG3158	transport of potassium into the cell
A6C57_RS10570	COG4771	TonB-dependent receptor
A6C57_RS10575	COG0702	epimerase
A6C57_RS10580	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6C57_RS10590	COG4771	TonB-dependent receptor
A6C57_RS10620	COG2755	lipolytic protein G-D-S-L family
A6C57_RS10625	COG3119	arylsulfatase activity
A6C57_RS10630	COG3401	FG-GAP repeat protein
A6C57_RS10635	COG2755	lipolytic protein G-D-S-L family
A6C57_RS10640	COG3347	Dehydrogenase
A6C57_RS10640	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS10650	COG3250	beta-galactosidase activity
A6C57_RS10660	COG3940	Belongs to the glycosyl hydrolase 43 family
A6C57_RS10665	COG3254	rhamnose metabolic process
A6C57_RS10670	COG0673	inositol 2-dehydrogenase activity
A6C57_RS10675	COG3250	beta-galactosidase activity
A6C57_RS10680	COG3401	FG-GAP repeat protein
A6C57_RS10700	COG3634	alkyl hydroperoxide reductase activity
A6C57_RS10720	COG1086	Polysaccharide biosynthesis protein
A6C57_RS10730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6C57_RS10740	COG1083	cytidylyl-transferase
A6C57_RS10755	COG2089	acid synthase
A6C57_RS10770	COG1620	l-lactate permease
A6C57_RS10780	COG0697	spore germination
A6C57_RS10785	COG0667	Aldo Keto reductase
A6C57_RS10790	COG4124	Belongs to the glycosyl hydrolase 26 family
A6C57_RS10805	COG3291	Pkd domain containing protein
A6C57_RS10815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6C57_RS10820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6C57_RS10850	COG0823	Involved in the tonB-independent uptake of proteins
A6C57_RS10855	COG4124	Belongs to the glycosyl hydrolase 26 family
A6C57_RS10865	COG0702	epimerase
A6C57_RS10870	COG1629	transport
A6C57_RS10885	COG1609	Transcriptional regulator
A6C57_RS10900	COG3661	Belongs to the glycosyl hydrolase 67 family
A6C57_RS10905	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS10910	COG1741	Belongs to the pirin family
A6C57_RS10950	COG1959	2 iron, 2 sulfur cluster binding
A6C57_RS10985	COG0628	permease
A6C57_RS10995	COG0745	RESPONSE REGULATOR receiver
A6C57_RS11000	COG5002	protein histidine kinase activity
A6C57_RS11005	COG0564	pseudouridine synthase activity
A6C57_RS11045	COG3275	phosphorelay sensor kinase activity
A6C57_RS11050	COG3279	Response regulator of the LytR AlgR family
A6C57_RS11085	COG4771	TonB-dependent receptor
A6C57_RS11090	COG1522	sequence-specific DNA binding
A6C57_RS11105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6C57_RS11120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6C57_RS11140	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6C57_RS11145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6C57_RS11150	COG1649	PFAM Uncharacterised BCR, COG1649
A6C57_RS11170	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6C57_RS11185	COG0277	FAD linked oxidase domain protein
A6C57_RS11185	COG0247	lactate metabolic process
A6C57_RS11200	COG1597	lipid kinase activity
A6C57_RS11205	COG0023	Translation Initiation Factor
A6C57_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS11235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6C57_RS11240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6C57_RS11245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6C57_RS11250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6C57_RS11270	COG0564	pseudouridine synthase activity
A6C57_RS11275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6C57_RS11300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6C57_RS11305	COG2204	response regulator
A6C57_RS11370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6C57_RS11380	COG2205	protein histidine kinase activity
A6C57_RS11380	COG0784	Response regulator, receiver
A6C57_RS11380	COG5002	protein histidine kinase activity
A6C57_RS11395	COG4251	negative regulation of phosphorylation
A6C57_RS11410	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6C57_RS11420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6C57_RS11425	COG0088	Forms part of the polypeptide exit tunnel
A6C57_RS11435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6C57_RS11440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6C57_RS11445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6C57_RS11450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6C57_RS11455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6C57_RS11460	COG0255	Belongs to the universal ribosomal protein uL29 family
A6C57_RS11465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6C57_RS11470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6C57_RS11475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6C57_RS11480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6C57_RS11485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6C57_RS11490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6C57_RS11495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6C57_RS11500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6C57_RS11505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6C57_RS11510	COG1841	ribosomal large subunit assembly
A6C57_RS11515	COG0200	Binds to the 23S rRNA
A6C57_RS11520	COG0201	protein transport
A6C57_RS11525	COG0024	Methionine aminopeptidase
A6C57_RS11530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6C57_RS11535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6C57_RS11540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6C57_RS11545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6C57_RS11550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6C57_RS11555	COG0202	RNA polymerase activity
A6C57_RS11560	COG0203	ribosomal protein L17
A6C57_RS11565	COG0505	Belongs to the CarA family
A6C57_RS11580	COG1902	pentaerythritol trinitrate reductase activity
A6C57_RS11585	COG1703	isobutyryl-CoA mutase activity
A6C57_RS11590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6C57_RS11595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6C57_RS11615	COG0243	molybdopterin cofactor binding
A6C57_RS11625	COG0484	heat shock protein binding
A6C57_RS11630	COG2514	catechol 2,3-dioxygenase activity
A6C57_RS11640	COG1595	DNA-templated transcription, initiation
A6C57_RS11660	COG2264	protein methyltransferase activity
A6C57_RS11680	COG1845	cytochrome c oxidase, subunit III
A6C57_RS11685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6C57_RS11730	COG0318	PFAM AMP-dependent synthetase and ligase
A6C57_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS11740	COG1312	Catalyzes the dehydration of D-mannonate
A6C57_RS11745	COG1216	Glycosyl transferase, family 2
A6C57_RS11755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6C57_RS11775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6C57_RS11790	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6C57_RS11795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6C57_RS11810	COG0135	phosphoribosylanthranilate isomerase activity
A6C57_RS11815	COG1193	negative regulation of DNA recombination
A6C57_RS11820	COG3118	belongs to the thioredoxin family
A6C57_RS11840	COG4771	TonB-dependent receptor
A6C57_RS11855	COG4771	TonB-dependent receptor
A6C57_RS11870	COG4771	TonB-dependent receptor
A6C57_RS11875	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A6C57_RS11880	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS11905	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6C57_RS11905	COG1388	LysM domain
A6C57_RS11915	COG1490	D-aminoacyl-tRNA deacylase activity
A6C57_RS11935	COG1902	pentaerythritol trinitrate reductase activity
A6C57_RS11945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6C57_RS11950	COG0492	ferredoxin-NADP+ reductase activity
A6C57_RS11965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6C57_RS12000	COG1278	Cold shock
A6C57_RS12030	COG3275	phosphorelay sensor kinase activity
A6C57_RS12035	COG3279	Response regulator of the LytR AlgR family
A6C57_RS12045	COG2204	response regulator
A6C57_RS12055	COG0784	Response regulator, receiver
A6C57_RS12060	COG3852	Histidine kinase
A6C57_RS12095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6C57_RS12115	COG1045	serine acetyltransferase
A6C57_RS12125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6C57_RS12135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6C57_RS12135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6C57_RS12170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6C57_RS12180	COG2814	Major facilitator Superfamily
A6C57_RS12210	COG4946	Tricorn protease homolog
A6C57_RS12210	COG0793	Belongs to the peptidase S41A family
A6C57_RS12215	COG1473	amidohydrolase
A6C57_RS12225	COG0596	Alpha beta hydrolase
A6C57_RS12255	COG2814	Major facilitator Superfamily
A6C57_RS12275	COG1012	belongs to the aldehyde dehydrogenase family
A6C57_RS12295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6C57_RS12300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6C57_RS12310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6C57_RS12315	COG0527	aspartate kinase activity
A6C57_RS12320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6C57_RS12335	COG0488	(ABC) transporter
A6C57_RS12375	COG1125	glycine betaine transport
A6C57_RS12375	COG0517	IMP dehydrogenase activity
A6C57_RS12385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6C57_RS12390	COG0571	ribonuclease III activity
A6C57_RS12395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6C57_RS12400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6C57_RS12405	COG0460	homoserine dehydrogenase
A6C57_RS12405	COG0527	aspartate kinase activity
A6C57_RS12410	COG0702	epimerase
A6C57_RS12425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6C57_RS12435	COG1136	(ABC) transporter
A6C57_RS12435	COG0577	efflux transmembrane transporter activity
A6C57_RS12465	COG1733	regulation of RNA biosynthetic process
A6C57_RS12475	COG0577	efflux transmembrane transporter activity
A6C57_RS12480	COG3047	cAMP biosynthetic process
A6C57_RS12480	COG2885	chlorophyll binding
A6C57_RS12490	COG3275	phosphorelay sensor kinase activity
A6C57_RS12500	COG3279	Response regulator of the LytR AlgR family
A6C57_RS12515	COG0604	alcohol dehydrogenase
A6C57_RS12515	COG3321	synthase
A6C57_RS12525	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A6C57_RS12530	COG1595	DNA-templated transcription, initiation
A6C57_RS12555	COG0577	efflux transmembrane transporter activity
A6C57_RS12565	COG0673	inositol 2-dehydrogenase activity
A6C57_RS12600	COG1136	(ABC) transporter
A6C57_RS12600	COG0577	efflux transmembrane transporter activity
A6C57_RS12610	COG1136	(ABC) transporter
A6C57_RS12610	COG0577	efflux transmembrane transporter activity
A6C57_RS12615	COG1136	(ABC) transporter
A6C57_RS12615	COG0577	efflux transmembrane transporter activity
A6C57_RS12635	COG0656	L-ascorbic acid biosynthetic process
A6C57_RS12650	COG0656	L-ascorbic acid biosynthetic process
A6C57_RS12680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6C57_RS12710	COG2910	NAD(P)H-binding
A6C57_RS12745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6C57_RS12770	COG4771	TonB-dependent receptor
A6C57_RS12800	COG3940	Belongs to the glycosyl hydrolase 43 family
A6C57_RS12845	COG4771	TonB-dependent receptor
A6C57_RS12865	COG1629	transport
A6C57_RS12865	COG4206	TonB-dependent receptor
A6C57_RS12875	COG2308	Evidence 4 Homologs of previously reported genes of
A6C57_RS12885	COG0596	Alpha beta hydrolase
A6C57_RS12890	COG4251	negative regulation of phosphorylation
A6C57_RS12900	COG2135	peptidase activity
A6C57_RS12905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6C57_RS12915	COG2205	protein histidine kinase activity
A6C57_RS12975	COG0083	homoserine kinase activity
A6C57_RS12995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6C57_RS13020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6C57_RS13090	COG2323	membrane
A6C57_RS13105	COG0714	Associated with various cellular activities
A6C57_RS13130	COG1363	Peptidase, m42
A6C57_RS13145	COG0481	GTPase activity
A6C57_RS13155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6C57_RS13160	COG0154	amidase activity
A6C57_RS13165	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6C57_RS13165	COG1388	LysM domain
A6C57_RS13170	COG0632	four-way junction helicase activity
A6C57_RS13195	COG3158	transport of potassium into the cell
A6C57_RS13200	COG2755	lipolytic protein G-D-S-L family
A6C57_RS13200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6C57_RS13205	COG1132	(ABC) transporter
A6C57_RS13210	COG4251	negative regulation of phosphorylation
A6C57_RS13230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6C57_RS13260	COG2201	protein-glutamate methylesterase activity
A6C57_RS13265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6C57_RS13285	COG1940	carbohydrate kinase activity
A6C57_RS13325	COG1136	(ABC) transporter
A6C57_RS13355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6C57_RS13390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6C57_RS13395	COG0509	glycine decarboxylation via glycine cleavage system
A6C57_RS13400	COG0167	dihydroorotate dehydrogenase activity
A6C57_RS13415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6C57_RS13420	COG0545	Peptidyl-prolyl cis-trans isomerase
A6C57_RS13430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6C57_RS13435	COG0792	nuclease activity
A6C57_RS13440	COG0788	formyltetrahydrofolate deformylase activity
A6C57_RS13460	COG0629	single-stranded DNA binding
A6C57_RS13470	COG0776	regulation of translation
A6C57_RS13480	COG1530	ribonuclease E activity
A6C57_RS13490	COG1640	4-alpha-glucanotransferase
A6C57_RS13495	COG0673	inositol 2-dehydrogenase activity
A6C57_RS13510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6C57_RS13515	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6C57_RS13530	COG1252	NADH dehydrogenase
A6C57_RS13540	COG4771	TonB-dependent receptor
A6C57_RS13555	COG1960	acyl-CoA dehydrogenase activity
A6C57_RS13560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6C57_RS13565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6C57_RS13570	COG0233	cytoplasmic translational termination
A6C57_RS13575	COG0528	UMP kinase activity
A6C57_RS13580	COG5016	pyruvate
A6C57_RS13580	COG0511	ligase activity, forming carbon-carbon bonds
A6C57_RS13595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6C57_RS13610	COG1704	LemA family
A6C57_RS13625	COG2814	Major facilitator Superfamily
A6C57_RS13630	COG2814	Major facilitator Superfamily
A6C57_RS13675	COG4251	negative regulation of phosphorylation
A6C57_RS13680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6C57_RS13685	COG0531	amino acid
A6C57_RS13720	COG0531	amino acid
A6C57_RS13735	COG0436	Aminotransferase
A6C57_RS13770	COG0702	epimerase
A6C57_RS13775	COG4771	TonB-dependent receptor
A6C57_RS13800	COG3956	TIGRFAM MazG family protein
A6C57_RS13825	COG2382	esterase
A6C57_RS13855	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6C57_RS13870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6C57_RS13875	COG0793	Belongs to the peptidase S41A family
A6C57_RS13900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6C57_RS13905	COG0148	phosphopyruvate hydratase activity
A6C57_RS13915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6C57_RS13920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6C57_RS13945	COG0628	permease
A6C57_RS13950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6C57_RS13955	COG1082	Xylose isomerase domain protein TIM barrel
A6C57_RS13970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6C57_RS13985	COG0583	DNA-binding transcription factor activity
A6C57_RS13995	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6C57_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS14015	COG3254	rhamnose metabolic process
A6C57_RS14035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6C57_RS14095	COG4932	domain protein
A6C57_RS14095	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A6C57_RS14095	COG3266	domain, Protein
A6C57_RS14110	COG4932	domain protein
A6C57_RS14110	COG3266	domain, Protein
A6C57_RS14110	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A6C57_RS14180	COG0436	Aminotransferase
A6C57_RS14210	COG0463	Glycosyl transferase, family 2
A6C57_RS14215	COG0367	asparagine synthase
A6C57_RS14220	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS14250	COG3206	protein involved in exopolysaccharide biosynthesis
A6C57_RS14250	COG0489	protein tyrosine kinase activity
A6C57_RS14260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6C57_RS14265	COG4464	protein tyrosine phosphatase activity
A6C57_RS14270	COG1266	CAAX protease self-immunity
A6C57_RS14300	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A6C57_RS14310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6C57_RS14315	COG2814	Major facilitator Superfamily
A6C57_RS14355	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A6C57_RS14355	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A6C57_RS14365	COG0463	Glycosyl transferase, family 2
A6C57_RS14385	COG3424	synthase
A6C57_RS14430	COG2030	dehydratase
A6C57_RS14455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6C57_RS14470	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A6C57_RS14475	COG2721	sulfolactate sulfo-lyase activity
A6C57_RS14480	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS14485	COG4771	TonB-dependent receptor
A6C57_RS14520	COG1418	mRNA catabolic process
A6C57_RS14545	COG0366	Alpha amylase catalytic
A6C57_RS14575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6C57_RS14575	COG0425	Belongs to the sulfur carrier protein TusA family
A6C57_RS14585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6C57_RS14590	COG1733	regulation of RNA biosynthetic process
A6C57_RS14595	COG3104	oligopeptide transport
A6C57_RS14610	COG4191	Histidine kinase
A6C57_RS14620	COG0137	argininosuccinate synthase activity
A6C57_RS14630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6C57_RS14640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6C57_RS14645	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS14650	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS14660	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS14690	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS14740	COG1605	Chorismate mutase
A6C57_RS14740	COG0077	Prephenate dehydratase
A6C57_RS14780	COG0424	maF-like protein
A6C57_RS14785	COG0668	transmembrane transport
A6C57_RS14795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6C57_RS14800	COG0531	amino acid
A6C57_RS14805	COG1012	belongs to the aldehyde dehydrogenase family
A6C57_RS14820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6C57_RS14820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6C57_RS14835	COG0644	oxidoreductase
A6C57_RS14840	COG1082	Xylose isomerase domain protein TIM barrel
A6C57_RS14845	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6C57_RS14845	COG0022	dehydrogenase e1 component
A6C57_RS14865	COG3537	Alpha-1,2-mannosidase
A6C57_RS14870	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6C57_RS14875	COG4771	TonB-dependent receptor
A6C57_RS14895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6C57_RS14910	COG1595	DNA-templated transcription, initiation
A6C57_RS14925	COG0784	Response regulator, receiver
A6C57_RS14930	COG1674	ftsk spoiiie
A6C57_RS14950	COG1007	ATP synthesis coupled electron transport
A6C57_RS14955	COG1253	flavin adenine dinucleotide binding
A6C57_RS14960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6C57_RS14965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6C57_RS14975	COG1809	phosphosulfolactate synthase activity
A6C57_RS14980	COG0586	Pfam SNARE associated Golgi protein
A6C57_RS14990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6C57_RS14995	COG0416	fatty acid biosynthetic process
A6C57_RS15000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6C57_RS15005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6C57_RS15015	COG0439	Biotin carboxylase
A6C57_RS15035	COG1652	LysM domain
A6C57_RS15040	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS15040	COG3347	Dehydrogenase
A6C57_RS15045	COG4952	isomerase
A6C57_RS15055	COG0247	lactate metabolic process
A6C57_RS15065	COG1556	Lactate utilization protein
A6C57_RS15070	COG1725	Transcriptional regulator
A6C57_RS15085	COG4251	negative regulation of phosphorylation
A6C57_RS15095	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6C57_RS15095	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6C57_RS15100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6C57_RS15105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6C57_RS15135	COG1331	Highly conserved protein containing a thioredoxin domain
A6C57_RS15155	COG3321	synthase
A6C57_RS15155	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS15155	COG0604	alcohol dehydrogenase
A6C57_RS15165	COG0415	Belongs to the DNA photolyase family
A6C57_RS15185	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6C57_RS15200	COG0423	glycine-tRNA ligase activity
A6C57_RS15250	COG1082	Xylose isomerase domain protein TIM barrel
A6C57_RS15270	COG0673	inositol 2-dehydrogenase activity
A6C57_RS15275	COG0463	Glycosyl transferase, family 2
A6C57_RS15300	COG3217	Mosc domain protein beta barrel domain protein
A6C57_RS15300	COG0633	Ferredoxin
A6C57_RS15310	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6C57_RS15315	COG0489	protein tyrosine kinase activity
A6C57_RS15325	COG0318	PFAM AMP-dependent synthetase and ligase
A6C57_RS15345	COG4251	negative regulation of phosphorylation
A6C57_RS15350	COG0359	binds to the 23S rRNA
A6C57_RS15355	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6C57_RS15360	COG0360	Binds together with S18 to 16S ribosomal RNA
A6C57_RS15370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6C57_RS15410	COG2885	chlorophyll binding
A6C57_RS15440	COG2094	Belongs to the DNA glycosylase MPG family
A6C57_RS15450	COG1561	YicC-like family, N-terminal region
A6C57_RS15455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6C57_RS15460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6C57_RS15465	COG2363	Small membrane protein
A6C57_RS15475	COG1446	asparaginase
A6C57_RS15480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6C57_RS15485	COG0673	inositol 2-dehydrogenase activity
A6C57_RS15500	COG2885	chlorophyll binding
A6C57_RS15505	COG0784	Response regulator, receiver
A6C57_RS15520	COG1349	DNA-binding transcription factor activity
A6C57_RS15525	COG0494	nUDIX hydrolase
A6C57_RS15535	COG0659	secondary active sulfate transmembrane transporter activity
A6C57_RS15545	COG3002	Belongs to the UPF0753 family
A6C57_RS15565	COG1309	transcriptional regulator
A6C57_RS15580	COG2723	6-phospho-beta-galactosidase activity
A6C57_RS15585	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A6C57_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS15605	COG2205	protein histidine kinase activity
A6C57_RS15645	COG3850	Histidine kinase
A6C57_RS15645	COG5002	protein histidine kinase activity
A6C57_RS15650	COG0745	RESPONSE REGULATOR receiver
A6C57_RS15655	COG0514	ATP-dependent DNA helicase (RecQ)
A6C57_RS15675	COG4115	mRNA cleavage
A6C57_RS15690	COG0045	succinate-CoA ligase (ADP-forming) activity
A6C57_RS15700	COG3250	beta-galactosidase activity
A6C57_RS15715	COG0673	inositol 2-dehydrogenase activity
A6C57_RS15745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6C57_RS15755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6C57_RS15770	COG0542	response to heat
A6C57_RS15805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6C57_RS15820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6C57_RS15830	COG3655	Transcriptional regulator
A6C57_RS15850	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6C57_RS15855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6C57_RS15865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6C57_RS15870	COG0187	DNA topoisomerase II activity
A6C57_RS15875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6C57_RS15890	COG1629	transport
A6C57_RS15890	COG4206	TonB-dependent receptor
A6C57_RS15910	COG0793	Belongs to the peptidase S41A family
A6C57_RS15910	COG4946	Tricorn protease homolog
A6C57_RS15930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6C57_RS15960	COG3250	beta-galactosidase activity
A6C57_RS15960	COG5297	Belongs to the glycosyl hydrolase family 6
A6C57_RS15965	COG3852	Histidine kinase
A6C57_RS15985	COG1024	Enoyl-CoA hydratase
A6C57_RS15995	COG2207	Transcriptional regulator
A6C57_RS16030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6C57_RS16030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6C57_RS16035	COG0697	spore germination
A6C57_RS16045	COG2885	chlorophyll binding
A6C57_RS16055	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A6C57_RS16070	COG0494	nUDIX hydrolase
A6C57_RS16075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6C57_RS16090	COG2151	metal-sulfur cluster biosynthetic enzyme
A6C57_RS16100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6C57_RS16125	COG0719	Fe-S assembly protein
A6C57_RS16130	COG0396	ATPase activity
A6C57_RS16150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6C57_RS16170	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A6C57_RS16185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6C57_RS16195	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6C57_RS16200	COG0612	Peptidase, M16
A6C57_RS16235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6C57_RS16245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A6C57_RS16250	COG2086	electron transfer activity
A6C57_RS16275	COG4948	Mandelate Racemase Muconate Lactonizing
A6C57_RS16290	COG1301	dicarboxylic acid transport
A6C57_RS16295	COG0488	(ABC) transporter
A6C57_RS16300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6C57_RS16315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6C57_RS16330	COG0343	queuine tRNA-ribosyltransferase activity
A6C57_RS16335	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS16340	COG0357	Ribosomal RNA small subunit methyltransferase G
A6C57_RS16355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6C57_RS16375	COG0667	Aldo Keto reductase
A6C57_RS16385	COG2814	Major facilitator Superfamily
A6C57_RS16405	COG1929	Belongs to the glycerate kinase type-1 family
A6C57_RS16410	COG3940	Belongs to the glycosyl hydrolase 43 family
A6C57_RS16435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6C57_RS16455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6C57_RS16475	COG0322	excinuclease ABC activity
A6C57_RS16500	COG0356	it plays a direct role in the translocation of protons across the membrane
A6C57_RS16505	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6C57_RS16510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6C57_RS16515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6C57_RS16520	COG0436	Aminotransferase
A6C57_RS16525	COG0287	Prephenate dehydrogenase
A6C57_RS16535	COG0667	Aldo Keto reductase
A6C57_RS16545	COG0017	Asparaginyl-tRNA synthetase
A6C57_RS16565	COG0071	Belongs to the small heat shock protein (HSP20) family
A6C57_RS16570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6C57_RS16590	COG4771	TonB-dependent receptor
A6C57_RS16595	COG0702	epimerase
A6C57_RS16600	COG3940	Belongs to the glycosyl hydrolase 43 family
A6C57_RS16610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6C57_RS16615	COG1765	OsmC-like protein
A6C57_RS16625	COG3279	Response regulator of the LytR AlgR family
A6C57_RS16630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6C57_RS16630	COG1648	precorrin-2 dehydrogenase activity
A6C57_RS16645	COG0166	Belongs to the GPI family
A6C57_RS16655	COG3757	hydrolase, family 25
A6C57_RS16665	COG0450	alkyl hydroperoxide reductase
A6C57_RS16695	COG0791	NLP P60 protein
A6C57_RS16705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6C57_RS16710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6C57_RS16715	COG4771	TonB-dependent receptor
A6C57_RS16740	COG1611	Belongs to the LOG family
A6C57_RS16750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6C57_RS16770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6C57_RS16780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6C57_RS16790	COG3237	CsbD-like
A6C57_RS16795	COG1022	Amp-dependent synthetase and ligase
A6C57_RS16820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6C57_RS16825	COG0534	Mate efflux family protein
A6C57_RS16840	COG1162	GTPase activity
A6C57_RS16855	COG0252	asparaginase activity
A6C57_RS16860	COG0084	hydrolase, TatD family'
A6C57_RS16865	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS16895	COG1196	nuclear chromosome segregation
A6C57_RS16895	COG0741	lytic transglycosylase activity
A6C57_RS16895	COG0739	heme binding
A6C57_RS16905	COG0531	amino acid
A6C57_RS16910	COG0739	heme binding
A6C57_RS16920	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6C57_RS16925	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6C57_RS16950	COG0673	inositol 2-dehydrogenase activity
A6C57_RS16960	COG1904	glucuronate isomerase
A6C57_RS16965	COG1312	Catalyzes the dehydration of D-mannonate
A6C57_RS16970	COG1609	Transcriptional regulator
A6C57_RS16985	COG4771	TonB-dependent receptor
A6C57_RS17015	COG0579	oxidoreductase
A6C57_RS17020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6C57_RS17035	COG4974	Belongs to the 'phage' integrase family
A6C57_RS17040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6C57_RS17045	COG0248	Ppx GppA phosphatase
A6C57_RS17075	COG2755	lipolytic protein G-D-S-L family
A6C57_RS17075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6C57_RS17080	COG4771	TonB-dependent receptor
A6C57_RS17085	COG0702	epimerase
A6C57_RS17105	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6C57_RS17135	COG4251	negative regulation of phosphorylation
A6C57_RS17165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6C57_RS17175	COG4974	Belongs to the 'phage' integrase family
A6C57_RS17180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6C57_RS17185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6C57_RS17190	COG2095	MarC family integral membrane protein
A6C57_RS17195	COG4112	unkown
A6C57_RS17205	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6C57_RS17210	COG1760	l-serine dehydratase
A6C57_RS17235	COG3220	belongs to the UPF0276 family
A6C57_RS17245	COG1082	Xylose isomerase domain protein TIM barrel
A6C57_RS17250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6C57_RS17255	COG0180	Tryptophanyl-tRNA synthetase
A6C57_RS17260	COG0280	phosphate acetyltransferase
A6C57_RS17260	COG0281	malic enzyme
A6C57_RS17295	COG0519	Catalyzes the synthesis of GMP from XMP
A6C57_RS17295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6C57_RS17315	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6C57_RS17320	COG0753	catalase activity
A6C57_RS17330	COG1132	(ABC) transporter
A6C57_RS17335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6C57_RS17350	COG1862	Preprotein translocase
A6C57_RS17370	COG2814	Major facilitator Superfamily
A6C57_RS17375	COG0598	Magnesium transport protein CorA
A6C57_RS17395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6C57_RS17430	COG0246	Mannitol dehydrogenase
A6C57_RS17435	COG2721	sulfolactate sulfo-lyase activity
A6C57_RS17440	COG1904	glucuronate isomerase
A6C57_RS17445	COG2271	Major facilitator Superfamily
A6C57_RS17450	COG4771	TonB-dependent receptor
A6C57_RS17455	COG0702	epimerase
A6C57_RS17470	COG2755	lipolytic protein G-D-S-L family
A6C57_RS17505	COG0288	reversible hydration of carbon dioxide
A6C57_RS17555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6C57_RS17580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6C57_RS17610	COG1546	Belongs to the CinA family
A6C57_RS17610	COG1058	Belongs to the CinA family
A6C57_RS17615	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6C57_RS17620	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
A6C57_RS17625	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6C57_RS17640	COG2267	carboxylic ester hydrolase activity
A6C57_RS17645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6C57_RS17655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6C57_RS17660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6C57_RS17665	COG1960	acyl-CoA dehydrogenase activity
A6C57_RS17695	COG0303	'Molybdopterin
A6C57_RS17705	COG0823	Involved in the tonB-independent uptake of proteins
A6C57_RS17720	COG2723	6-phospho-beta-galactosidase activity
A6C57_RS17740	COG0228	four-way junction DNA binding
A6C57_RS17745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6C57_RS17750	COG0336	Belongs to the RNA methyltransferase TrmD family
A6C57_RS17795	COG2819	hydrolase of the alpha beta superfamily
A6C57_RS17805	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6C57_RS17820	COG0463	Glycosyl transferase, family 2
A6C57_RS17835	COG0495	leucyl-tRNA aminoacylation
A6C57_RS17840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6C57_RS17860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6C57_RS17870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6C57_RS17885	COG4206	TonB-dependent receptor
A6C57_RS17885	COG1629	transport
A6C57_RS17895	COG1629	transport
A6C57_RS17895	COG4206	TonB-dependent receptor
A6C57_RS17910	COG1629	transport
A6C57_RS17920	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6C57_RS17925	COG1629	transport
A6C57_RS17930	COG1473	amidohydrolase
A6C57_RS17935	COG0300	oxidoreductase activity
A6C57_RS17940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6C57_RS17955	COG0772	Belongs to the SEDS family
A6C57_RS18000	COG0217	transcriptional regulatory protein
A6C57_RS18005	COG0019	diaminopimelate decarboxylase activity
A6C57_RS18030	COG2814	Major facilitator Superfamily
A6C57_RS18050	COG4772	TonB-dependent receptor
A6C57_RS18055	COG1193	negative regulation of DNA recombination
A6C57_RS18075	COG0564	pseudouridine synthase activity
A6C57_RS18080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A6C57_RS18085	COG2072	flavoprotein involved in K transport
A6C57_RS18090	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6C57_RS18095	COG1803	Methylglyoxal synthase
A6C57_RS18095	COG1597	lipid kinase activity
A6C57_RS18105	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6C57_RS18130	COG0174	glutamine synthetase
A6C57_RS18150	COG0542	response to heat
A6C57_RS18165	COG1428	Deoxynucleoside kinase
A6C57_RS18175	COG0697	spore germination
A6C57_RS18190	COG0443	Heat shock 70 kDa protein
A6C57_RS18210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6C57_RS18215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6C57_RS18220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6C57_RS18225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6C57_RS18235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6C57_RS18235	COG0116	Belongs to the methyltransferase superfamily
A6C57_RS18240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6C57_RS18255	COG4654	Cytochrome c, class I
A6C57_RS18265	COG3591	Belongs to the peptidase S1B family
A6C57_RS18280	COG1702	phosphate starvation-inducible protein PhoH
A6C57_RS18290	COG2153	protein acetylation
A6C57_RS18295	COG2333	competence protein COMEC
A6C57_RS18295	COG0658	competence protein
A6C57_RS18305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6C57_RS18335	COG0463	Glycosyl transferase, family 2
A6C57_RS18335	COG1216	Glycosyl transferase, family 2
A6C57_RS18365	COG3119	arylsulfatase activity
A6C57_RS18380	COG0366	Alpha amylase catalytic
A6C57_RS18405	COG4251	negative regulation of phosphorylation
A6C57_RS18415	COG1496	oxidoreductase activity
A6C57_RS18420	COG3279	Response regulator of the LytR AlgR family
A6C57_RS18425	COG0540	Belongs to the ATCase OTCase family
A6C57_RS18440	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6C57_RS18445	COG4206	TonB-dependent receptor
A6C57_RS18445	COG1629	transport
A6C57_RS18470	COG0714	Associated with various cellular activities
A6C57_RS18475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6C57_RS18480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6C57_RS18495	COG0708	Exodeoxyribonuclease III
A6C57_RS18500	COG1187	pseudouridine synthase activity
A6C57_RS18525	COG1074	ATP-dependent DNA helicase activity
A6C57_RS18535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6C57_RS18560	COG0131	Imidazoleglycerol-phosphate dehydratase
A6C57_RS18560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6C57_RS18590	COG0339	signal peptide processing
A6C57_RS18595	COG2353	YceI-like domain
A6C57_RS18610	COG0243	molybdopterin cofactor binding
A6C57_RS18615	COG2223	nitrite transmembrane transporter activity
A6C57_RS18620	COG1648	precorrin-2 dehydrogenase activity
A6C57_RS18620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6C57_RS18625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6C57_RS18635	COG0366	Alpha amylase catalytic
A6C57_RS18655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6C57_RS18665	COG0297	glycogen (starch) synthase activity
A6C57_RS18680	COG1404	Belongs to the peptidase S8 family
A6C57_RS18715	COG0577	efflux transmembrane transporter activity
A6C57_RS18725	COG2226	methyltransferase
A6C57_RS18790	COG4974	Belongs to the 'phage' integrase family
A6C57_RS18865	COG0531	amino acid
A6C57_RS18885	COG1523	belongs to the glycosyl hydrolase 13 family
A6C57_RS18900	COG1054	Belongs to the UPF0176 family
A6C57_RS18905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6C57_RS18905	COG1648	precorrin-2 dehydrogenase activity
A6C57_RS18910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6C57_RS18915	COG2080	2 iron, 2 sulfur cluster binding
A6C57_RS18920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6C57_RS18925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6C57_RS18930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6C57_RS18930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6C57_RS18935	COG2895	sulfate adenylyltransferase (ATP) activity
A6C57_RS18940	COG0175	sulfate reduction
A6C57_RS18945	COG0175	sulfate reduction
A6C57_RS18960	COG0730	response to heat
A6C57_RS18980	COG2252	PERMEase
A6C57_RS18985	COG1396	sequence-specific DNA binding
A6C57_RS18990	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS19045	COG0702	epimerase
A6C57_RS19050	COG4771	TonB-dependent receptor
A6C57_RS19080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6C57_RS19085	COG0101	tRNA pseudouridine synthase activity
A6C57_RS19100	COG2205	protein histidine kinase activity
A6C57_RS19110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6C57_RS19110	COG3153	acetyltransferase
A6C57_RS19115	COG1764	response to oxidative stress
A6C57_RS19125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6C57_RS19130	COG1185	polyribonucleotide nucleotidyltransferase activity
A6C57_RS19135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6C57_RS19160	COG2133	pyrroloquinoline quinone binding
A6C57_RS19165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6C57_RS19170	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6C57_RS19175	COG2080	2 iron, 2 sulfur cluster binding
A6C57_RS19190	COG4753	response regulator
A6C57_RS19190	COG2207	Transcriptional regulator
A6C57_RS19260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6C57_RS19270	COG0442	prolyl-tRNA aminoacylation
A6C57_RS19285	COG0656	L-ascorbic acid biosynthetic process
A6C57_RS19305	COG0165	Argininosuccinate lyase
A6C57_RS19310	COG1482	cell wall glycoprotein biosynthetic process
A6C57_RS19335	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6C57_RS19340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6C57_RS19365	COG2949	membrane
A6C57_RS19375	COG5265	(ABC) transporter
A6C57_RS19380	COG0739	heme binding
A6C57_RS19385	COG0384	phenazine biosynthesis protein PhzF
A6C57_RS19395	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A6C57_RS19425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6C57_RS19435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6C57_RS19485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6C57_RS19485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6C57_RS19490	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6C57_RS19495	COG4712	double-strand break repair protein
A6C57_RS19500	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6C57_RS19510	COG0512	Glutamine amidotransferase of anthranilate synthase
A6C57_RS19515	COG2267	carboxylic ester hydrolase activity
A6C57_RS19525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6C57_RS19550	COG0617	tRNA 3'-terminal CCA addition
A6C57_RS19555	COG0009	L-threonylcarbamoyladenylate synthase
A6C57_RS19565	COG0018	arginyl-trna synthetase
A6C57_RS19570	COG0386	Belongs to the glutathione peroxidase family
A6C57_RS19575	COG1575	Belongs to the MenA family. Type 1 subfamily
A6C57_RS19580	COG1566	PFAM secretion protein HlyD family protein
A6C57_RS19585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6C57_RS19590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6C57_RS19610	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A6C57_RS19615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6C57_RS19680	COG0542	response to heat
A6C57_RS19780	COG2378	regulation of single-species biofilm formation
A6C57_RS19785	COG1404	Belongs to the peptidase S8 family
A6C57_RS19790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6C57_RS19815	COG0745	RESPONSE REGULATOR receiver
A6C57_RS19825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6C57_RS19855	COG2133	pyrroloquinoline quinone binding
A6C57_RS19880	COG0237	dephospho-CoA kinase activity
A6C57_RS19885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6C57_RS19890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6C57_RS19910	COG3850	Histidine kinase
A6C57_RS19910	COG5002	protein histidine kinase activity
A6C57_RS19930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6C57_RS19960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6C57_RS19965	COG0617	tRNA 3'-terminal CCA addition
A6C57_RS19965	COG0517	IMP dehydrogenase activity
A6C57_RS19965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6C57_RS19980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6C57_RS19990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6C57_RS19995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6C57_RS20015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6C57_RS20020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6C57_RS20025	COG0259	pyridoxamine-phosphate oxidase activity
A6C57_RS20045	COG4251	negative regulation of phosphorylation
A6C57_RS20055	COG0626	cystathionine gamma-synthase activity
A6C57_RS20075	COG4251	negative regulation of phosphorylation
A6C57_RS20085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6C57_RS20115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6C57_RS20125	COG2171	N-acyltransferase activity
A6C57_RS20145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6C57_RS20165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6C57_RS20170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6C57_RS20175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6C57_RS20180	COG0366	Alpha amylase catalytic
A6C57_RS20205	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS20235	COG0069	glutamate synthase activity
A6C57_RS20235	COG0070	glutamate synthase
A6C57_RS20235	COG0067	glutamate synthase
A6C57_RS20280	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6C57_RS20305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6C57_RS20310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6C57_RS20340	COG1289	transmembrane transporter activity
A6C57_RS20370	COG3530	Putative quorum-sensing-regulated virulence factor
A6C57_RS20380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A6C57_RS20430	COG0631	protein serine/threonine phosphatase activity
A6C57_RS20435	COG0515	serine threonine protein kinase
A6C57_RS20440	COG0515	serine threonine protein kinase
A6C57_RS20445	COG0772	Belongs to the SEDS family
A6C57_RS20455	COG0671	phosphoesterase, PA-phosphatase related
A6C57_RS20480	COG0318	PFAM AMP-dependent synthetase and ligase
A6C57_RS20505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A6C57_RS20525	COG3119	arylsulfatase activity
A6C57_RS20540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6C57_RS20545	COG0484	heat shock protein binding
A6C57_RS20555	COG2323	membrane
A6C57_RS20585	COG2942	2-epimerase
A6C57_RS20590	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A6C57_RS20600	COG4977	sequence-specific DNA binding
A6C57_RS20605	COG3118	belongs to the thioredoxin family
A6C57_RS20605	COG0492	ferredoxin-NADP+ reductase activity
A6C57_RS20610	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6C57_RS20615	COG4771	TonB-dependent receptor
A6C57_RS20645	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS20675	COG0702	epimerase
A6C57_RS20680	COG4771	TonB-dependent receptor
A6C57_RS20690	COG3292	Two component regulator propeller
A6C57_RS20690	COG2205	protein histidine kinase activity
A6C57_RS20690	COG0745	RESPONSE REGULATOR receiver
A6C57_RS20695	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6C57_RS20700	COG1609	Transcriptional regulator
A6C57_RS20710	COG0405	Gamma-glutamyltransferase
A6C57_RS20750	COG0655	NAD(P)H dehydrogenase (quinone) activity
A6C57_RS20755	COG0427	acetyl-CoA hydrolase
A6C57_RS20775	COG0513	Belongs to the DEAD box helicase family
A6C57_RS20780	COG0513	Belongs to the DEAD box helicase family
A6C57_RS20785	COG0513	Belongs to the DEAD box helicase family
A6C57_RS20795	COG0564	pseudouridine synthase activity
A6C57_RS20815	COG2133	pyrroloquinoline quinone binding
A6C57_RS20820	COG0300	oxidoreductase activity
A6C57_RS20825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6C57_RS20830	COG0670	Belongs to the BI1 family
A6C57_RS20855	COG0438	transferase activity, transferring glycosyl groups
A6C57_RS20865	COG5434	Belongs to the glycosyl hydrolase 28 family
A6C57_RS20880	COG0110	maltose O-acetyltransferase activity
A6C57_RS20885	COG1216	Glycosyl transferase, family 2
A6C57_RS20940	COG1047	Peptidyl-prolyl cis-trans
A6C57_RS21010	COG0363	glucosamine-6-phosphate deaminase activity
A6C57_RS21015	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6C57_RS21020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6C57_RS21050	COG1999	signal sequence binding
A6C57_RS21055	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS21060	COG0302	gtp cyclohydrolase
A6C57_RS21070	COG3239	Fatty acid desaturase
A6C57_RS21075	COG2884	Cell division ATP-binding protein ftsE
A6C57_RS21080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6C57_RS21085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6C57_RS21090	COG0328	RNA-DNA hybrid ribonuclease activity
A6C57_RS21090	COG3341	Caulimovirus viroplasmin
A6C57_RS21105	COG1136	(ABC) transporter
A6C57_RS21120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6C57_RS21135	COG0640	Transcriptional regulator
A6C57_RS21145	COG0783	Belongs to the Dps family
A6C57_RS21150	COG2235	arginine
A6C57_RS21180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6C57_RS21245	COG0154	amidase activity
A6C57_RS21260	COG2814	Major facilitator Superfamily
A6C57_RS21265	COG0673	inositol 2-dehydrogenase activity
A6C57_RS21270	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS21275	COG1902	pentaerythritol trinitrate reductase activity
A6C57_RS21295	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A6C57_RS21320	COG0300	oxidoreductase activity
A6C57_RS21330	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A6C57_RS21345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6C57_RS21350	COG0598	Magnesium transport protein CorA
A6C57_RS21375	COG2318	DinB family
A6C57_RS21385	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A6C57_RS21390	COG4251	negative regulation of phosphorylation
A6C57_RS21395	COG4251	negative regulation of phosphorylation
A6C57_RS21400	COG4251	negative regulation of phosphorylation
A6C57_RS21405	COG1629	transport
A6C57_RS21405	COG4206	TonB-dependent receptor
A6C57_RS21415	COG2080	2 iron, 2 sulfur cluster binding
A6C57_RS21420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6C57_RS21425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6C57_RS21435	COG1595	DNA-templated transcription, initiation
A6C57_RS21475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6C57_RS21480	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6C57_RS21485	COG2080	2 iron, 2 sulfur cluster binding
A6C57_RS21490	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS21510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6C57_RS21565	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS21575	COG0596	Alpha beta hydrolase
A6C57_RS21580	COG0604	alcohol dehydrogenase
A6C57_RS21585	COG0028	Belongs to the TPP enzyme family
A6C57_RS21600	COG3119	arylsulfatase activity
A6C57_RS21655	COG3228	Belongs to the MtfA family
A6C57_RS21670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6C57_RS21675	COG3938	Belongs to the proline racemase family
A6C57_RS21680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6C57_RS21690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6C57_RS21710	COG2081	HI0933 family
A6C57_RS21720	COG1047	Peptidyl-prolyl cis-trans
A6C57_RS21725	COG4294	response to UV
A6C57_RS21730	COG2311	Membrane
A6C57_RS21765	COG2271	Major facilitator Superfamily
A6C57_RS21770	COG1131	(ABC) transporter
A6C57_RS21790	COG1073	alpha beta
A6C57_RS21800	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6C57_RS21815	COG1629	transport
A6C57_RS21815	COG4206	TonB-dependent receptor
A6C57_RS21835	COG1940	carbohydrate kinase activity
A6C57_RS21835	COG1846	Transcriptional regulator
A6C57_RS21840	COG1063	alcohol dehydrogenase
A6C57_RS21850	COG0604	alcohol dehydrogenase
A6C57_RS21865	COG1695	Transcriptional regulator
A6C57_RS21905	COG2211	Major facilitator Superfamily
A6C57_RS21915	COG0602	queuosine metabolic process
A6C57_RS21920	COG2885	chlorophyll binding
A6C57_RS21920	COG3047	cAMP biosynthetic process
A6C57_RS21925	COG2017	converts alpha-aldose to the beta-anomer
A6C57_RS21940	COG0628	permease
A6C57_RS21960	COG3292	Two component regulator propeller
A6C57_RS21960	COG2205	protein histidine kinase activity
A6C57_RS21960	COG0745	RESPONSE REGULATOR receiver
A6C57_RS21980	COG1064	alcohol dehydrogenase
A6C57_RS22005	COG4993	Dehydrogenase
A6C57_RS22015	COG4977	sequence-specific DNA binding
A6C57_RS22025	COG1309	transcriptional regulator
A6C57_RS22030	COG2353	YceI-like domain
A6C57_RS22035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6C57_RS22040	COG0778	Nitroreductase
A6C57_RS22075	COG3537	Alpha-1,2-mannosidase
A6C57_RS22080	COG0673	inositol 2-dehydrogenase activity
A6C57_RS22095	COG5492	domain, Protein
A6C57_RS22100	COG0025	NhaP-type Na H and K H
A6C57_RS22110	COG2226	methyltransferase
A6C57_RS22125	COG4771	TonB-dependent receptor
A6C57_RS22135	COG3250	beta-galactosidase activity
A6C57_RS22145	COG0492	ferredoxin-NADP+ reductase activity
A6C57_RS22145	COG3118	belongs to the thioredoxin family
A6C57_RS22150	COG2860	membrane
A6C57_RS22155	COG0667	Aldo Keto reductase
A6C57_RS22160	COG4251	negative regulation of phosphorylation
A6C57_RS22190	COG4251	negative regulation of phosphorylation
A6C57_RS22200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6C57_RS22200	COG2755	lipolytic protein G-D-S-L family
A6C57_RS22205	COG4251	negative regulation of phosphorylation
A6C57_RS22240	COG3275	phosphorelay sensor kinase activity
A6C57_RS22280	COG1917	Cupin 2, conserved barrel domain protein
A6C57_RS22280	COG2169	Transcriptional regulator
A6C57_RS22295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6C57_RS22310	COG2217	Heavy metal translocating P-type atpase
A6C57_RS22350	COG0667	Aldo Keto reductase
A6C57_RS22365	COG2814	Major facilitator Superfamily
A6C57_RS22375	COG0583	DNA-binding transcription factor activity
A6C57_RS22380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6C57_RS22390	COG1309	transcriptional regulator
A6C57_RS22425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A6C57_RS22430	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A6C57_RS22435	COG0298	carbon dioxide binding
A6C57_RS22450	COG0309	Hydrogenase expression formation protein (HypE)
A6C57_RS22495	COG2205	protein histidine kinase activity
A6C57_RS22495	COG3292	Two component regulator propeller
A6C57_RS22495	COG0745	RESPONSE REGULATOR receiver
A6C57_RS22500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6C57_RS22535	COG2205	protein histidine kinase activity
A6C57_RS22535	COG0745	RESPONSE REGULATOR receiver
A6C57_RS22535	COG3292	Two component regulator propeller
A6C57_RS22550	COG4251	negative regulation of phosphorylation
A6C57_RS22560	COG2259	Doxx family
A6C57_RS22580	COG3119	arylsulfatase activity
A6C57_RS22580	COG3408	Glycogen debranching enzyme
A6C57_RS22590	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6C57_RS22625	COG4771	TonB-dependent receptor
A6C57_RS22640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6C57_RS22640	COG2205	protein histidine kinase activity
A6C57_RS22645	COG0673	inositol 2-dehydrogenase activity
A6C57_RS22685	COG4771	TonB-dependent receptor
A6C57_RS22730	COG3275	phosphorelay sensor kinase activity
A6C57_RS22735	COG3275	phosphorelay sensor kinase activity
A6C57_RS22740	COG3275	phosphorelay sensor kinase activity
A6C57_RS22765	COG4771	TonB-dependent receptor
A6C57_RS22795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6C57_RS22800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6C57_RS22805	COG3720	iron ion transport
A6C57_RS22815	COG2072	flavoprotein involved in K transport
A6C57_RS22890	COG2354	Protein conserved in bacteria
A6C57_RS22905	COG1215	transferase activity, transferring glycosyl groups
A6C57_RS22940	COG3275	phosphorelay sensor kinase activity
A6C57_RS22945	COG3275	phosphorelay sensor kinase activity
A6C57_RS22985	COG2186	Transcriptional regulator
A6C57_RS22990	COG2814	Major facilitator Superfamily
A6C57_RS22995	COG1629	transport
A6C57_RS23000	COG0702	epimerase
A6C57_RS23025	COG1940	carbohydrate kinase activity
A6C57_RS23040	COG4974	Belongs to the 'phage' integrase family
A6C57_RS23045	COG1012	belongs to the aldehyde dehydrogenase family
A6C57_RS23055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6C57_RS23075	COG4251	negative regulation of phosphorylation
A6C57_RS23095	COG2304	oxidoreductase activity
A6C57_RS23105	COG0183	Belongs to the thiolase family
A6C57_RS23110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6C57_RS23120	COG1234	tRNA 3'-trailer cleavage
A6C57_RS23125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6C57_RS23135	COG0513	Belongs to the DEAD box helicase family
A6C57_RS23140	COG3201	nicotinamide mononucleotide transporter
A6C57_RS23165	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS23170	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS23185	COG0642	Histidine kinase
A6C57_RS23205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6C57_RS23220	COG2124	cytochrome p450
A6C57_RS23225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6C57_RS23240	COG0590	tRNA wobble adenosine to inosine editing
A6C57_RS23260	COG0662	Cupin 2, conserved barrel domain protein
A6C57_RS23260	COG2207	Transcriptional regulator
A6C57_RS23265	COG2217	Heavy metal translocating P-type atpase
A6C57_RS23290	COG0492	ferredoxin-NADP+ reductase activity
A6C57_RS23295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6C57_RS23300	COG0129	dihydroxy-acid dehydratase activity
A6C57_RS23320	COG0006	proline dipeptidase activity
A6C57_RS23330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6C57_RS23340	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6C57_RS23360	COG1522	sequence-specific DNA binding
A6C57_RS23365	COG4221	oxidoreductase activity
A6C57_RS23375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6C57_RS23375	COG1796	DNA polymerase
A6C57_RS23380	COG0504	CTP synthase activity
A6C57_RS23385	COG0706	membrane insertase activity
A6C57_RS23395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6C57_RS23405	COG0463	Glycosyl transferase, family 2
A6C57_RS23405	COG1216	Glycosyl transferase, family 2
A6C57_RS23415	COG2824	Alkylphosphonate utilization operon protein PhnA
A6C57_RS23430	COG0124	histidyl-tRNA synthetase
A6C57_RS23450	COG0004	ammonium transporteR
A6C57_RS23460	COG1192	Involved in chromosome partitioning
A6C57_RS23465	COG1475	DNA binding
A6C57_RS23790	COG4974	Belongs to the 'phage' integrase family
A6C57_RS23800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6C57_RS23805	COG0681	Belongs to the peptidase S26 family
A6C57_RS23810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6C57_RS23815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6C57_RS23825	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS23830	COG0730	response to heat
A6C57_RS23835	COG3118	belongs to the thioredoxin family
A6C57_RS23865	COG0545	Peptidyl-prolyl cis-trans isomerase
A6C57_RS23880	COG1506	peptidase
A6C57_RS23880	COG0823	Involved in the tonB-independent uptake of proteins
A6C57_RS23885	COG4771	TonB-dependent receptor
A6C57_RS23890	COG0702	epimerase
A6C57_RS23895	COG1629	transport
A6C57_RS23900	COG0702	epimerase
A6C57_RS23910	COG0667	Aldo Keto reductase
A6C57_RS23950	COG2226	methyltransferase
A6C57_RS23970	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6C57_RS23990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6C57_RS24010	COG0463	Glycosyl transferase, family 2
A6C57_RS24045	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A6C57_RS24050	COG2996	Protein conserved in bacteria
A6C57_RS24055	COG0009	L-threonylcarbamoyladenylate synthase
A6C57_RS24065	COG2177	Part of the ABC transporter FtsEX involved in
A6C57_RS24075	COG1968	undecaprenyl-diphosphatase activity
A6C57_RS24080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6C57_RS24085	COG0196	riboflavin kinase activity
A6C57_RS24095	COG4221	oxidoreductase activity
A6C57_RS24115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6C57_RS24120	COG0429	hydrolase of the alpha beta-hydrolase fold
A6C57_RS24125	COG4251	negative regulation of phosphorylation
A6C57_RS24130	COG2205	protein histidine kinase activity
A6C57_RS24130	COG2198	Histidine kinase
A6C57_RS24130	COG0784	Response regulator, receiver
A6C57_RS24135	COG3437	response regulator, receiver
A6C57_RS24135	COG4999	Histidine kinase
A6C57_RS24135	COG2205	protein histidine kinase activity
A6C57_RS24135	COG3850	Histidine kinase
A6C57_RS24140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6C57_RS24155	COG0791	NLP P60 protein
A6C57_RS24170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6C57_RS24180	COG3620	sequence-specific DNA binding
A6C57_RS24185	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6C57_RS24200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6C57_RS24205	COG0735	belongs to the Fur family
A6C57_RS24210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6C57_RS24215	COG3685	Protein conserved in bacteria
A6C57_RS24235	COG1032	radical SAM domain protein
A6C57_RS24245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6C57_RS24255	COG0542	response to heat
A6C57_RS24270	COG1233	COG1233 Phytoene dehydrogenase and related
A6C57_RS24310	COG0714	Associated with various cellular activities
A6C57_RS24315	COG2890	protein-(glutamine-N5) methyltransferase activity
A6C57_RS24330	COG1253	flavin adenine dinucleotide binding
A6C57_RS24335	COG0746	molybdenum cofactor guanylyltransferase activity
A6C57_RS24335	COG0315	cyclic pyranopterin monophosphate synthase activity
A6C57_RS24340	COG0746	molybdenum cofactor guanylyltransferase activity
A6C57_RS24340	COG0315	cyclic pyranopterin monophosphate synthase activity
A6C57_RS24345	COG0363	glucosamine-6-phosphate deaminase activity
A6C57_RS24355	COG1960	acyl-CoA dehydrogenase activity
A6C57_RS24360	COG4682	membrane
A6C57_RS24365	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6C57_RS24370	COG0596	Alpha beta hydrolase
A6C57_RS24395	COG0494	nUDIX hydrolase
A6C57_RS24400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6C57_RS24405	COG3844	kynureninase activity
A6C57_RS24410	COG1309	transcriptional regulator
A6C57_RS24415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6C57_RS24425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6C57_RS24450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6C57_RS24470	COG4251	negative regulation of phosphorylation
A6C57_RS24490	COG1733	regulation of RNA biosynthetic process
A6C57_RS24495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6C57_RS24530	COG2270	Major facilitator Superfamily
A6C57_RS24565	COG0784	Response regulator, receiver
A6C57_RS24565	COG2198	Histidine kinase
A6C57_RS24565	COG5002	protein histidine kinase activity
A6C57_RS24570	COG0784	Response regulator, receiver
A6C57_RS24570	COG2205	protein histidine kinase activity
A6C57_RS24570	COG2198	Histidine kinase
A6C57_RS24605	COG1609	Transcriptional regulator
A6C57_RS24610	COG3781	membrane
A6C57_RS24625	COG0745	RESPONSE REGULATOR receiver
A6C57_RS24630	COG0408	coproporphyrinogen oxidase activity
A6C57_RS24640	COG4948	Mandelate Racemase Muconate Lactonizing
A6C57_RS24645	COG1663	tetraacyldisaccharide 4'-kinase activity
A6C57_RS24655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6C57_RS24665	COG3852	Histidine kinase
A6C57_RS24670	COG3876	Protein conserved in bacteria
A6C57_RS24675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6C57_RS24695	COG1570	exodeoxyribonuclease VII activity
A6C57_RS24715	COG0673	inositol 2-dehydrogenase activity
A6C57_RS24735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6C57_RS24750	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6C57_RS24755	COG0482	sulfurtransferase activity
A6C57_RS24770	COG0316	Belongs to the HesB IscA family
A6C57_RS24775	COG5000	phosphorelay sensor kinase activity
A6C57_RS24790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6C57_RS24800	COG1183	phosphatidylcholine synthase activity
A6C57_RS24805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6C57_RS24815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6C57_RS24820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6C57_RS24840	COG1999	signal sequence binding
A6C57_RS24850	COG0497	DNA recombination
A6C57_RS24895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6C57_RS24900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6C57_RS24905	COG0799	negative regulation of ribosome biogenesis
A6C57_RS24970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6C57_RS24975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6C57_RS24990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6C57_RS24990	COG3743	rRNA binding
A6C57_RS25005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6C57_RS25010	COG1028	Short-chain dehydrogenase reductase Sdr
A6C57_RS25025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6C57_RS25045	COG0193	aminoacyl-tRNA hydrolase activity
A6C57_RS25065	COG0281	malic enzyme
A6C57_RS25065	COG0280	phosphate acetyltransferase
A6C57_RS25070	COG1301	dicarboxylic acid transport
A6C57_RS25080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6C57_RS25090	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6C57_RS25095	COG4771	TonB-dependent receptor
A6C57_RS25110	COG1629	transport
A6C57_RS25115	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6C57_RS25120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6C57_RS25125	COG3590	peptidase
A6C57_RS25180	COG1078	dGTPase activity
A6C57_RS25185	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6C57_RS25190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6C57_RS25190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6C57_RS25195	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6C57_RS25200	COG1131	(ABC) transporter
A6C57_RS25225	COG0402	S-adenosylhomocysteine deaminase activity
A6C57_RS25235	COG2271	Major facilitator Superfamily
A6C57_RS25240	COG0246	Mannitol dehydrogenase
A6C57_RS25245	COG3011	Protein conserved in bacteria
A6C57_RS25250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6C57_RS25255	COG4251	negative regulation of phosphorylation
A6C57_RS25260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6C57_RS25265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6C57_RS25285	COG2353	YceI-like domain
A6C57_RS25305	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6C57_RS25340	COG1104	cysteine desulfurase activity
A6C57_RS25365	COG2311	Membrane
A6C57_RS25370	COG2311	Membrane
A6C57_RS25395	COG1187	pseudouridine synthase activity
A6C57_RS25405	COG1629	transport
A6C57_RS25435	COG0546	phosphoglycolate phosphatase activity
A6C57_RS25455	COG3590	peptidase
A6C57_RS25460	COG3227	Zinc metalloprotease (Elastase)
A6C57_RS25500	COG5002	protein histidine kinase activity
A6C57_RS25545	COG2272	Belongs to the type-B carboxylesterase lipase family
A6C57_RS25550	COG2272	Belongs to the type-B carboxylesterase lipase family
A6C57_RS25580	COG3118	belongs to the thioredoxin family
A6C57_RS25595	COG2003	Belongs to the UPF0758 family
A6C57_RS25600	COG0268	Binds directly to 16S ribosomal RNA
A6C57_RS25660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6C57_RS25665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6C57_RS25670	COG1116	anion transmembrane transporter activity
A6C57_RS25690	COG0714	Associated with various cellular activities
A6C57_RS25720	COG1473	amidohydrolase
A6C57_RS25725	COG0784	Response regulator, receiver
A6C57_RS25735	COG5180	pathogenesis
A6C57_RS25735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6C57_RS25735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6C57_RS25735	COG5180	pathogenesis
A6C57_RS25740	COG0195	Participates in both transcription termination and antitermination
A6C57_RS25740	COG2251	uridine kinase activity
A6C57_RS25745	COG0779	Required for maturation of 30S ribosomal subunits
A6C57_RS25755	COG0314	molybdopterin synthase activity
A6C57_RS25795	COG0584	glycerophosphoryl diester phosphodiesterase
A6C57_RS25805	COG4251	negative regulation of phosphorylation
A6C57_RS25820	COG1858	cytochrome C peroxidase
A6C57_RS25830	COG0673	inositol 2-dehydrogenase activity
A6C57_RS25850	COG0393	Putative heavy-metal-binding
A6C57_RS25860	COG4974	Belongs to the 'phage' integrase family