locus-tag	class	description
EPD17_RS00015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EPD17_RS00020	COG0756	dUTP diphosphatase activity
EPD17_RS00035	COG0438	transferase activity, transferring glycosyl groups
EPD17_RS00050	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPD17_RS00060	COG2094	Belongs to the DNA glycosylase MPG family
EPD17_RS00065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPD17_RS00105	COG0673	inositol 2-dehydrogenase activity
EPD17_RS00130	COG1366	Belongs to the anti-sigma-factor antagonist family
EPD17_RS00135	COG1366	Belongs to the anti-sigma-factor antagonist family
EPD17_RS00140	COG2172	sigma factor antagonist activity
EPD17_RS00150	COG4251	negative regulation of phosphorylation
EPD17_RS00155	COG0745	RESPONSE REGULATOR receiver
EPD17_RS00160	COG1473	amidohydrolase
EPD17_RS00170	COG0084	hydrolase, TatD family'
EPD17_RS00180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPD17_RS00195	COG1024	Enoyl-CoA hydratase
EPD17_RS00205	COG0514	ATP-dependent DNA helicase (RecQ)
EPD17_RS00215	COG0802	atpase or kinase
EPD17_RS00230	COG0346	lactoylglutathione lyase activity
EPD17_RS00255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPD17_RS00260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPD17_RS00260	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPD17_RS00275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPD17_RS00280	COG0113	porphobilinogen synthase activity
EPD17_RS00285	COG0408	coproporphyrinogen oxidase activity
EPD17_RS00295	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPD17_RS00305	COG0181	hydroxymethylbilane synthase activity
EPD17_RS00310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPD17_RS00315	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPD17_RS00320	COG1981	membrane
EPD17_RS00325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPD17_RS00345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPD17_RS00350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPD17_RS00355	COG0571	ribonuclease III activity
EPD17_RS00365	COG0346	lactoylglutathione lyase activity
EPD17_RS00370	COG1104	cysteine desulfurase activity
EPD17_RS00375	COG0822	iron-sulfur transferase activity
EPD17_RS00380	COG0316	Belongs to the HesB IscA family
EPD17_RS00395	COG0861	Integral membrane protein TerC family
EPD17_RS00400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPD17_RS00405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EPD17_RS00410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EPD17_RS00445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD17_RS00450	COG2270	Major facilitator Superfamily
EPD17_RS00460	COG1968	undecaprenyl-diphosphatase activity
EPD17_RS00470	COG2177	Part of the ABC transporter FtsEX involved in
EPD17_RS00475	COG0495	leucyl-tRNA aminoacylation
EPD17_RS00540	COG1064	alcohol dehydrogenase
EPD17_RS00570	COG2255	four-way junction helicase activity
EPD17_RS00600	COG0791	NLP P60 protein
EPD17_RS00610	COG0401	homolog of Blt101
EPD17_RS00615	COG0537	adenosine 5'-monophosphoramidase activity
EPD17_RS00620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPD17_RS00635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPD17_RS00640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPD17_RS00655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPD17_RS00665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EPD17_RS00715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPD17_RS00725	COG0643	Histidine kinase
EPD17_RS00725	COG0784	Response regulator, receiver
EPD17_RS00725	COG2198	Histidine kinase
EPD17_RS00730	COG3850	Histidine kinase
EPD17_RS00730	COG5002	protein histidine kinase activity
EPD17_RS00735	COG0745	RESPONSE REGULATOR receiver
EPD17_RS00740	COG3850	Histidine kinase
EPD17_RS00740	COG3437	response regulator, receiver
EPD17_RS00740	COG2205	protein histidine kinase activity
EPD17_RS00740	COG4999	Histidine kinase
EPD17_RS00745	COG4251	negative regulation of phosphorylation
EPD17_RS00750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPD17_RS00755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EPD17_RS00760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPD17_RS00765	COG0356	it plays a direct role in the translocation of protons across the membrane
EPD17_RS00775	COG1132	(ABC) transporter
EPD17_RS00785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPD17_RS00795	COG0306	phosphate transporter
EPD17_RS00815	COG3610	response to peptide
EPD17_RS00840	COG5002	protein histidine kinase activity
EPD17_RS00845	COG0745	RESPONSE REGULATOR receiver
EPD17_RS00870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPD17_RS00890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPD17_RS00900	COG4206	TonB-dependent receptor
EPD17_RS00900	COG1629	transport
EPD17_RS00910	COG4771	TonB-dependent receptor
EPD17_RS00915	COG2409	Drug exporters of the RND superfamily
EPD17_RS00915	COG1033	growth of symbiont in host cell
EPD17_RS00920	COG1381	Involved in DNA repair and RecF pathway recombination
EPD17_RS00925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPD17_RS00930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPD17_RS00935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPD17_RS00940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPD17_RS00945	COG0739	heme binding
EPD17_RS00975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPD17_RS00980	COG1556	Lactate utilization protein
EPD17_RS00985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPD17_RS01005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPD17_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
EPD17_RS01035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPD17_RS01050	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EPD17_RS01055	COG0594	ribonuclease P activity
EPD17_RS01060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EPD17_RS01065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EPD17_RS01070	COG0590	tRNA wobble adenosine to inosine editing
EPD17_RS01090	COG1012	belongs to the aldehyde dehydrogenase family
EPD17_RS01110	COG0386	Belongs to the glutathione peroxidase family
EPD17_RS01115	COG2076	Multidrug Resistance protein
EPD17_RS01130	COG1266	CAAX protease self-immunity
EPD17_RS01135	COG0575	Belongs to the CDS family
EPD17_RS01150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPD17_RS01165	COG1309	transcriptional regulator
EPD17_RS01175	COG4771	TonB-dependent receptor
EPD17_RS01295	COG2824	Alkylphosphonate utilization operon protein PhnA
EPD17_RS01310	COG1506	peptidase
EPD17_RS01320	COG0754	glutathionylspermidine amidase activity
EPD17_RS01360	COG0596	Alpha beta hydrolase
EPD17_RS01365	COG0673	inositol 2-dehydrogenase activity
EPD17_RS01375	COG0463	Glycosyl transferase, family 2
EPD17_RS01385	COG0252	asparaginase activity
EPD17_RS01390	COG1764	response to oxidative stress
EPD17_RS01410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPD17_RS01430	COG2132	Multicopper oxidase
EPD17_RS01445	COG0708	Exodeoxyribonuclease III
EPD17_RS01455	COG0776	regulation of translation
EPD17_RS01465	COG0259	pyridoxamine-phosphate oxidase activity
EPD17_RS01475	COG0528	UMP kinase activity
EPD17_RS01490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPD17_RS01495	COG0052	Belongs to the universal ribosomal protein uS2 family
EPD17_RS01500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPD17_RS01505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPD17_RS01510	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EPD17_RS01520	COG0556	nucleotide-excision repair
EPD17_RS01530	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPD17_RS01570	COG0702	epimerase
EPD17_RS01575	COG4206	TonB-dependent receptor
EPD17_RS01575	COG1629	transport
EPD17_RS01580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPD17_RS01620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPD17_RS01625	COG0366	Alpha amylase catalytic
EPD17_RS01635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPD17_RS01655	COG1064	alcohol dehydrogenase
EPD17_RS01670	COG0412	Dienelactone hydrolase
EPD17_RS01705	COG0210	DNA helicase
EPD17_RS01710	COG4804	nuclease activity
EPD17_RS01715	COG0724	RNA recognition motif
EPD17_RS01720	COG3279	Response regulator of the LytR AlgR family
EPD17_RS01725	COG3275	phosphorelay sensor kinase activity
EPD17_RS01750	COG1764	response to oxidative stress
EPD17_RS01770	COG4447	cellulose binding
EPD17_RS01830	COG2814	Major facilitator Superfamily
EPD17_RS01835	COG2133	pyrroloquinoline quinone binding
EPD17_RS01870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPD17_RS01875	COG0393	Putative heavy-metal-binding
EPD17_RS01880	COG3591	Belongs to the peptidase S1B family
EPD17_RS01895	COG0562	UDP-galactopyranose mutase
EPD17_RS01920	COG1215	transferase activity, transferring glycosyl groups
EPD17_RS01925	COG1215	transferase activity, transferring glycosyl groups
EPD17_RS01930	COG2442	InterPro IPR007367
EPD17_RS01960	COG1217	gtp-binding protein TYPA
EPD17_RS01980	COG1612	heme a metabolic process
EPD17_RS01985	COG3757	hydrolase, family 25
EPD17_RS02020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EPD17_RS02025	COG3059	membrane
EPD17_RS02060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPD17_RS02060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPD17_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS02080	COG0346	lactoylglutathione lyase activity
EPD17_RS02110	COG3279	Response regulator of the LytR AlgR family
EPD17_RS02115	COG3275	phosphorelay sensor kinase activity
EPD17_RS02125	COG1137	ATPase activity
EPD17_RS02130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPD17_RS02155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPD17_RS02160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPD17_RS02165	COG0450	alkyl hydroperoxide reductase
EPD17_RS02170	COG1846	Transcriptional regulator
EPD17_RS02185	COG1051	belongs to the nudix hydrolase family
EPD17_RS02190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPD17_RS02195	COG1024	Enoyl-CoA hydratase
EPD17_RS02200	COG2050	protein possibly involved in aromatic compounds catabolism
EPD17_RS02230	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPD17_RS02240	COG0363	glucosamine-6-phosphate deaminase activity
EPD17_RS02250	COG1473	amidohydrolase
EPD17_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS02260	COG0667	Aldo Keto reductase
EPD17_RS02275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EPD17_RS02280	COG4948	Mandelate Racemase Muconate Lactonizing
EPD17_RS02290	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EPD17_RS02295	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EPD17_RS02295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPD17_RS02310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPD17_RS02335	COG3609	addiction module antidote protein, CC2985 family
EPD17_RS02355	COG1216	Glycosyl transferase, family 2
EPD17_RS02360	COG0483	inositol monophosphate 1-phosphatase activity
EPD17_RS02365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPD17_RS02390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPD17_RS02410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPD17_RS02440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPD17_RS02475	COG3254	rhamnose metabolic process
EPD17_RS02480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EPD17_RS02490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPD17_RS02495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPD17_RS02510	COG0492	ferredoxin-NADP+ reductase activity
EPD17_RS02515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPD17_RS02520	COG0436	Aminotransferase
EPD17_RS02540	COG0517	IMP dehydrogenase activity
EPD17_RS02540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPD17_RS02545	COG0514	ATP-dependent DNA helicase (RecQ)
EPD17_RS02560	COG0445	tRNA wobble uridine modification
EPD17_RS02570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPD17_RS02580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EPD17_RS02590	COG1473	amidohydrolase
EPD17_RS02615	COG2154	pterin-4-alpha-carbinolamine dehydratase
EPD17_RS02625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EPD17_RS02630	COG0017	Asparaginyl-tRNA synthetase
EPD17_RS02665	COG0724	RNA recognition motif
EPD17_RS02690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EPD17_RS02700	COG2045	Belongs to the ComB family
EPD17_RS02705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPD17_RS02710	COG4804	nuclease activity
EPD17_RS02750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPD17_RS02790	COG1228	amidohydrolase
EPD17_RS02800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EPD17_RS02805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPD17_RS02810	COG0612	Peptidase, M16
EPD17_RS02820	COG1950	PFAM Membrane protein of
EPD17_RS02825	COG0022	dehydrogenase e1 component
EPD17_RS02840	COG1058	Belongs to the CinA family
EPD17_RS02840	COG1546	Belongs to the CinA family
EPD17_RS02850	COG1082	Xylose isomerase domain protein TIM barrel
EPD17_RS02875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPD17_RS02885	COG0437	4 iron, 4 sulfur cluster binding
EPD17_RS02915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPD17_RS02920	COG0109	protoheme IX farnesyltransferase activity
EPD17_RS02925	COG1845	cytochrome c oxidase, subunit III
EPD17_RS02930	COG1845	cytochrome c oxidase, subunit III
EPD17_RS02955	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS02960	COG1596	polysaccharide export
EPD17_RS02995	COG1216	Glycosyl transferase, family 2
EPD17_RS03045	COG1012	belongs to the aldehyde dehydrogenase family
EPD17_RS03045	COG2030	dehydratase
EPD17_RS03055	COG0563	adenylate kinase activity
EPD17_RS03060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPD17_RS03075	COG4221	oxidoreductase activity
EPD17_RS03080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPD17_RS03110	COG0745	RESPONSE REGULATOR receiver
EPD17_RS03140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPD17_RS03150	COG3396	Phenylacetate-CoA oxygenase
EPD17_RS03155	COG3460	Phenylacetate-CoA oxygenase
EPD17_RS03160	COG3396	Phenylacetate-CoA oxygenase
EPD17_RS03165	COG2151	metal-sulfur cluster biosynthetic enzyme
EPD17_RS03170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPD17_RS03175	COG0009	L-threonylcarbamoyladenylate synthase
EPD17_RS03185	COG1404	Belongs to the peptidase S8 family
EPD17_RS03185	COG4412	M6 family metalloprotease domain protein
EPD17_RS03190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPD17_RS03205	COG4206	TonB-dependent receptor
EPD17_RS03205	COG1629	transport
EPD17_RS03275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPD17_RS03285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPD17_RS03330	COG1629	transport
EPD17_RS03360	COG2814	Major facilitator Superfamily
EPD17_RS03385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPD17_RS03390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPD17_RS03405	COG1454	alcohol dehydrogenase
EPD17_RS03410	COG0598	Magnesium transport protein CorA
EPD17_RS03495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPD17_RS03500	COG1022	Amp-dependent synthetase and ligase
EPD17_RS03525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EPD17_RS03545	COG0724	RNA recognition motif
EPD17_RS03550	COG2202	Pas domain
EPD17_RS03550	COG1366	Belongs to the anti-sigma-factor antagonist family
EPD17_RS03565	COG4269	membrane
EPD17_RS03630	COG4974	Belongs to the 'phage' integrase family
EPD17_RS03685	COG1396	sequence-specific DNA binding
EPD17_RS03695	COG3550	peptidyl-serine autophosphorylation
EPD17_RS03705	COG3384	dioxygenase
EPD17_RS03710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EPD17_RS03735	COG2032	superoxide dismutase activity
EPD17_RS03750	COG2814	Major facilitator Superfamily
EPD17_RS03800	COG0738	Major facilitator superfamily
EPD17_RS03810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EPD17_RS03820	COG4771	TonB-dependent receptor
EPD17_RS03825	COG0702	epimerase
EPD17_RS03860	COG1073	alpha beta
EPD17_RS03875	COG0779	Required for maturation of 30S ribosomal subunits
EPD17_RS03880	COG0195	Participates in both transcription termination and antitermination
EPD17_RS03885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPD17_RS03895	COG0793	Belongs to the peptidase S41A family
EPD17_RS03895	COG4946	Tricorn protease homolog
EPD17_RS03910	COG3590	peptidase
EPD17_RS03935	COG1136	(ABC) transporter
EPD17_RS03940	COG0577	efflux transmembrane transporter activity
EPD17_RS03950	COG2204	response regulator
EPD17_RS03955	COG4191	Histidine kinase
EPD17_RS03965	COG1013	pyruvate-flavodoxin oxidoreductase activity
EPD17_RS03985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPD17_RS03990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPD17_RS04020	COG1215	transferase activity, transferring glycosyl groups
EPD17_RS04025	COG0438	transferase activity, transferring glycosyl groups
EPD17_RS04045	COG1139	Iron-sulfur cluster binding protein
EPD17_RS04055	COG0697	spore germination
EPD17_RS04060	COG0138	bifunctional purine biosynthesis protein purh
EPD17_RS04065	COG2333	competence protein COMEC
EPD17_RS04065	COG0658	competence protein
EPD17_RS04075	COG4251	negative regulation of phosphorylation
EPD17_RS04090	COG3851	Histidine kinase
EPD17_RS04095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPD17_RS04100	COG0346	lactoylglutathione lyase activity
EPD17_RS04145	COG3483	tryptophan 2,3-dioxygenase activity
EPD17_RS04150	COG0151	Belongs to the GarS family
EPD17_RS04155	COG3104	oligopeptide transport
EPD17_RS04190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EPD17_RS04200	COG1522	sequence-specific DNA binding
EPD17_RS04205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPD17_RS04210	COG1215	transferase activity, transferring glycosyl groups
EPD17_RS04215	COG1846	Transcriptional regulator
EPD17_RS04220	COG1960	acyl-CoA dehydrogenase activity
EPD17_RS04230	COG2361	Protein of unknown function DUF86
EPD17_RS04240	COG2321	neutral zinc metallopeptidase
EPD17_RS04255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPD17_RS04265	COG0768	penicillin binding
EPD17_RS04270	COG0772	Belongs to the SEDS family
EPD17_RS04290	COG0513	Belongs to the DEAD box helicase family
EPD17_RS04295	COG4628	conserved protein (DUF2132)
EPD17_RS04325	COG1086	Polysaccharide biosynthesis protein
EPD17_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS04355	COG1725	Transcriptional regulator
EPD17_RS04365	COG1131	(ABC) transporter
EPD17_RS04405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPD17_RS04415	COG1077	Cell shape determining protein MreB Mrl
EPD17_RS04430	COG1472	Belongs to the glycosyl hydrolase 3 family
EPD17_RS04440	COG1774	PSP1 C-terminal conserved region
EPD17_RS04450	COG0386	Belongs to the glutathione peroxidase family
EPD17_RS04460	COG1040	competence protein
EPD17_RS04465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPD17_RS04475	COG4206	TonB-dependent receptor
EPD17_RS04475	COG1629	transport
EPD17_RS04485	COG1629	transport
EPD17_RS04490	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPD17_RS04495	COG1530	ribonuclease E activity
EPD17_RS04505	COG0776	regulation of translation
EPD17_RS04510	COG1194	a g-specific adenine glycosylase
EPD17_RS04515	COG0629	single-stranded DNA binding
EPD17_RS04530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPD17_RS04530	COG0723	plastoquinol--plastocyanin reductase activity
EPD17_RS04555	COG2267	carboxylic ester hydrolase activity
EPD17_RS04570	COG3275	phosphorelay sensor kinase activity
EPD17_RS04580	COG0626	cystathionine gamma-synthase activity
EPD17_RS04585	COG0367	asparagine synthase
EPD17_RS04625	COG3591	Belongs to the peptidase S1B family
EPD17_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS04645	COG0698	ribose 5-phosphate isomerase
EPD17_RS04650	COG0805	protein transport
EPD17_RS04660	COG1253	flavin adenine dinucleotide binding
EPD17_RS04665	COG0194	GDP metabolic process
EPD17_RS04685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPD17_RS04705	COG1610	YqeY-like protein
EPD17_RS04720	COG0517	IMP dehydrogenase activity
EPD17_RS04730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPD17_RS04785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPD17_RS04820	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPD17_RS04830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPD17_RS04835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPD17_RS04865	COG2133	pyrroloquinoline quinone binding
EPD17_RS04935	COG1132	(ABC) transporter
EPD17_RS04940	COG0612	Peptidase, M16
EPD17_RS04970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EPD17_RS04970	COG0674	pyruvate-flavodoxin oxidoreductase activity
EPD17_RS05010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPD17_RS05015	COG3622	Belongs to the hyi family
EPD17_RS05065	COG2323	membrane
EPD17_RS05100	COG1902	pentaerythritol trinitrate reductase activity
EPD17_RS05105	COG0753	catalase activity
EPD17_RS05115	COG1012	belongs to the aldehyde dehydrogenase family
EPD17_RS05130	COG1703	isobutyryl-CoA mutase activity
EPD17_RS05130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD17_RS05130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD17_RS05155	COG1660	Displays ATPase and GTPase activities
EPD17_RS05160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPD17_RS05175	COG5002	protein histidine kinase activity
EPD17_RS05190	COG0300	oxidoreductase activity
EPD17_RS05200	COG0688	phosphatidylethanolamine metabolic process
EPD17_RS05215	COG4750	Nucleotidyl transferase
EPD17_RS05240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPD17_RS05245	COG0556	nucleotide-excision repair
EPD17_RS05250	COG1803	Methylglyoxal synthase
EPD17_RS05255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPD17_RS05275	COG0488	(ABC) transporter
EPD17_RS05285	COG0671	phosphoesterase, PA-phosphatase related
EPD17_RS05290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EPD17_RS05300	COG0745	RESPONSE REGULATOR receiver
EPD17_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS05310	COG1295	ribonuclease BN
EPD17_RS05340	COG0456	acetyltransferase
EPD17_RS05380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EPD17_RS05400	COG0251	oxidation-reduction process
EPD17_RS05405	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPD17_RS05410	COG1595	DNA-templated transcription, initiation
EPD17_RS05430	COG1002	Type II restriction enzyme, methylase subunits
EPD17_RS05445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPD17_RS05455	COG0477	Major facilitator Superfamily
EPD17_RS05495	COG0288	reversible hydration of carbon dioxide
EPD17_RS05510	COG1131	(ABC) transporter
EPD17_RS05525	COG0148	phosphopyruvate hydratase activity
EPD17_RS05540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPD17_RS05560	COG0693	protein deglycase activity
EPD17_RS05595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPD17_RS05600	COG3153	acetyltransferase
EPD17_RS05610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPD17_RS05615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPD17_RS05635	COG0156	8-amino-7-oxononanoate synthase activity
EPD17_RS05700	COG0489	protein tyrosine kinase activity
EPD17_RS05705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD17_RS05715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EPD17_RS05720	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EPD17_RS05735	COG2089	acid synthase
EPD17_RS05740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPD17_RS05750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPD17_RS05770	COG0463	Glycosyl transferase, family 2
EPD17_RS05775	COG1215	transferase activity, transferring glycosyl groups
EPD17_RS05780	COG0297	glycogen (starch) synthase activity
EPD17_RS05805	COG2197	response regulator
EPD17_RS05825	COG0297	glycogen (starch) synthase activity
EPD17_RS05835	COG4464	protein tyrosine phosphatase activity
EPD17_RS05860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EPD17_RS05875	COG3118	belongs to the thioredoxin family
EPD17_RS05880	COG0628	permease
EPD17_RS05890	COG0513	Belongs to the DEAD box helicase family
EPD17_RS05910	COG1940	carbohydrate kinase activity
EPD17_RS05915	COG4206	TonB-dependent receptor
EPD17_RS05915	COG1629	transport
EPD17_RS05970	COG3537	Alpha-1,2-mannosidase
EPD17_RS05975	COG1446	asparaginase
EPD17_RS05980	COG3142	Participates in the control of copper homeostasis
EPD17_RS06000	COG3119	arylsulfatase activity
EPD17_RS06005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPD17_RS06010	COG2186	Transcriptional regulator
EPD17_RS06015	COG4771	TonB-dependent receptor
EPD17_RS06025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPD17_RS06030	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EPD17_RS06070	COG3119	arylsulfatase activity
EPD17_RS06090	COG0363	glucosamine-6-phosphate deaminase activity
EPD17_RS06110	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EPD17_RS06135	COG3655	Transcriptional regulator
EPD17_RS06140	COG3023	N-Acetylmuramoyl-L-alanine amidase
EPD17_RS06195	COG3386	PFAM SMP-30 Gluconolaconase
EPD17_RS06205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPD17_RS06215	COG3254	rhamnose metabolic process
EPD17_RS06230	COG0667	Aldo Keto reductase
EPD17_RS06245	COG4251	negative regulation of phosphorylation
EPD17_RS06250	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EPD17_RS06255	COG3852	Histidine kinase
EPD17_RS06310	COG2095	MarC family integral membrane protein
EPD17_RS06325	COG4206	TonB-dependent receptor
EPD17_RS06335	COG0531	amino acid
EPD17_RS06340	COG0626	cystathionine gamma-synthase activity
EPD17_RS06350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPD17_RS06355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPD17_RS06360	COG2351	hydroxyisourate hydrolase activity
EPD17_RS06365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPD17_RS06385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EPD17_RS06405	COG0322	excinuclease ABC activity
EPD17_RS06425	COG4771	TonB-dependent receptor
EPD17_RS06435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPD17_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS06465	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPD17_RS06470	COG3618	amidohydrolase
EPD17_RS06475	COG0673	inositol 2-dehydrogenase activity
EPD17_RS06485	COG0246	Mannitol dehydrogenase
EPD17_RS06490	COG1904	glucuronate isomerase
EPD17_RS06500	COG0800	Aldolase
EPD17_RS06515	COG3254	rhamnose metabolic process
EPD17_RS06580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPD17_RS06585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPD17_RS06635	COG4771	TonB-dependent receptor
EPD17_RS06640	COG0702	epimerase
EPD17_RS06680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EPD17_RS06685	COG0667	Aldo Keto reductase
EPD17_RS06705	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPD17_RS06710	COG1078	dGTPase activity
EPD17_RS06730	COG0321	lipoyl(octanoyl) transferase activity
EPD17_RS06730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EPD17_RS06735	COG1960	acyl-CoA dehydrogenase activity
EPD17_RS06745	COG1132	(ABC) transporter
EPD17_RS06750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPD17_RS06760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPD17_RS06765	COG0233	cytoplasmic translational termination
EPD17_RS06775	COG2326	polyphosphate kinase activity
EPD17_RS06780	COG1970	mechanosensitive ion channel activity
EPD17_RS06785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EPD17_RS06790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPD17_RS06795	COG3275	phosphorelay sensor kinase activity
EPD17_RS06820	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EPD17_RS06825	COG1629	transport
EPD17_RS06850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPD17_RS06875	COG0628	permease
EPD17_RS06880	COG4251	negative regulation of phosphorylation
EPD17_RS06885	COG0488	(ABC) transporter
EPD17_RS06895	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPD17_RS06905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPD17_RS06910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPD17_RS06920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPD17_RS06925	COG0741	lytic transglycosylase activity
EPD17_RS06930	COG0154	amidase activity
EPD17_RS06935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPD17_RS06940	COG0335	large ribosomal subunit rRNA binding
EPD17_RS06950	COG1418	mRNA catabolic process
EPD17_RS06975	COG1132	(ABC) transporter
EPD17_RS06990	COG3424	synthase
EPD17_RS07025	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EPD17_RS07030	COG2226	methyltransferase
EPD17_RS07045	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD17_RS07050	COG3940	Belongs to the glycosyl hydrolase 43 family
EPD17_RS07055	COG0702	epimerase
EPD17_RS07060	COG4771	TonB-dependent receptor
EPD17_RS07075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPD17_RS07080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD17_RS07085	COG0183	Belongs to the thiolase family
EPD17_RS07090	COG0167	dihydroorotate dehydrogenase activity
EPD17_RS07110	COG0305	Participates in initiation and elongation during chromosome replication
EPD17_RS07125	COG0628	permease
EPD17_RS07135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPD17_RS07140	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPD17_RS07155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPD17_RS07195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPD17_RS07200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPD17_RS07215	COG1678	Uncharacterized ACR, COG1678
EPD17_RS07225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPD17_RS07230	COG2001	Belongs to the MraZ family
EPD17_RS07235	COG0275	rRNA processing
EPD17_RS07245	COG0768	penicillin binding
EPD17_RS07250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPD17_RS07255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPD17_RS07260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPD17_RS07265	COG0772	Belongs to the SEDS family
EPD17_RS07270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPD17_RS07275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPD17_RS07290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPD17_RS07300	COG4251	negative regulation of phosphorylation
EPD17_RS07335	COG0492	ferredoxin-NADP+ reductase activity
EPD17_RS07345	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPD17_RS07345	COG1024	Enoyl-CoA hydratase
EPD17_RS07360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPD17_RS07360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPD17_RS07365	COG1619	proteins homologs of microcin C7 resistance protein MccF
EPD17_RS07370	COG1619	proteins homologs of microcin C7 resistance protein MccF
EPD17_RS07380	COG4152	abc transporter atp-binding protein
EPD17_RS07390	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EPD17_RS07395	COG2207	Transcriptional regulator
EPD17_RS07400	COG1629	transport
EPD17_RS07405	COG0561	phosphatase activity
EPD17_RS07420	COG4124	Belongs to the glycosyl hydrolase 26 family
EPD17_RS07425	COG4124	Belongs to the glycosyl hydrolase 26 family
EPD17_RS07435	COG1472	Belongs to the glycosyl hydrolase 3 family
EPD17_RS07440	COG2211	Major facilitator Superfamily
EPD17_RS07445	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EPD17_RS07450	COG2942	2-epimerase
EPD17_RS07460	COG0737	Belongs to the 5'-nucleotidase family
EPD17_RS07465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPD17_RS07480	COG4974	Belongs to the 'phage' integrase family
EPD17_RS07490	COG3177	Filamentation induced by cAMP protein fic
EPD17_RS07495	COG1132	(ABC) transporter
EPD17_RS07530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPD17_RS07535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPD17_RS07535	COG0116	Belongs to the methyltransferase superfamily
EPD17_RS07620	COG0537	adenosine 5'-monophosphoramidase activity
EPD17_RS07625	COG0210	DNA helicase
EPD17_RS07670	COG0501	Belongs to the peptidase M48B family
EPD17_RS07685	COG0730	response to heat
EPD17_RS07690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD17_RS07690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPD17_RS07710	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPD17_RS07715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD17_RS07720	COG2080	2 iron, 2 sulfur cluster binding
EPD17_RS07725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EPD17_RS07730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPD17_RS07745	COG0303	'Molybdopterin
EPD17_RS07750	COG0730	response to heat
EPD17_RS07760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPD17_RS07765	COG0314	molybdopterin synthase activity
EPD17_RS07770	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPD17_RS07770	COG0315	cyclic pyranopterin monophosphate synthase activity
EPD17_RS07775	COG3608	succinylglutamate desuccinylase aspartoacylase
EPD17_RS07775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EPD17_RS07825	COG1187	pseudouridine synthase activity
EPD17_RS07855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPD17_RS07860	COG2252	PERMEase
EPD17_RS07865	COG0667	Aldo Keto reductase
EPD17_RS07880	COG3851	Histidine kinase
EPD17_RS07910	COG1054	Belongs to the UPF0176 family
EPD17_RS07935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPD17_RS07950	COG0504	CTP synthase activity
EPD17_RS07955	COG0706	membrane insertase activity
EPD17_RS07975	COG1809	phosphosulfolactate synthase activity
EPD17_RS07980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPD17_RS08000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPD17_RS08010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPD17_RS08015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EPD17_RS08020	COG0049	tRNA binding
EPD17_RS08035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPD17_RS08045	COG0051	transcription antitermination factor activity, RNA binding
EPD17_RS08050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPD17_RS08055	COG0088	Forms part of the polypeptide exit tunnel
EPD17_RS08060	COG0089	rRNA binding
EPD17_RS08065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPD17_RS08070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPD17_RS08080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EPD17_RS08085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EPD17_RS08090	COG0255	Belongs to the universal ribosomal protein uL29 family
EPD17_RS08095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPD17_RS08100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EPD17_RS08105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPD17_RS08110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPD17_RS08115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPD17_RS08120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPD17_RS08125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPD17_RS08130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EPD17_RS08135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EPD17_RS08140	COG1841	ribosomal large subunit assembly
EPD17_RS08145	COG0200	Binds to the 23S rRNA
EPD17_RS08160	COG2081	HI0933 family
EPD17_RS08190	COG0673	inositol 2-dehydrogenase activity
EPD17_RS08205	COG0673	inositol 2-dehydrogenase activity
EPD17_RS08215	COG2272	Belongs to the type-B carboxylesterase lipase family
EPD17_RS08220	COG4989	oxidoreductase activity
EPD17_RS08225	COG3275	phosphorelay sensor kinase activity
EPD17_RS08230	COG3279	Response regulator of the LytR AlgR family
EPD17_RS08260	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD17_RS08265	COG4251	negative regulation of phosphorylation
EPD17_RS08270	COG4191	Histidine kinase
EPD17_RS08270	COG0784	Response regulator, receiver
EPD17_RS08345	COG0745	RESPONSE REGULATOR receiver
EPD17_RS08345	COG3292	Two component regulator propeller
EPD17_RS08345	COG2205	protein histidine kinase activity
EPD17_RS08345	COG0745	RESPONSE REGULATOR receiver
EPD17_RS08345	COG3292	Two component regulator propeller
EPD17_RS08345	COG2205	protein histidine kinase activity
EPD17_RS08360	COG0612	Peptidase, M16
EPD17_RS08365	COG4585	Histidine kinase
EPD17_RS08370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
EPD17_RS08375	COG4251	negative regulation of phosphorylation
EPD17_RS08380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPD17_RS08385	COG1228	amidohydrolase
EPD17_RS08415	COG2111	Na H antiporter
EPD17_RS08415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPD17_RS08425	COG1006	Multisubunit Na H antiporter MnhC subunit
EPD17_RS08430	COG0651	ATP synthesis coupled electron transport
EPD17_RS08435	COG1863	multisubunit Na H antiporter MnhE subunit
EPD17_RS08440	COG2212	antiporter activity
EPD17_RS08445	COG1320	monovalent cation:proton antiporter activity
EPD17_RS08460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPD17_RS08515	COG1629	transport
EPD17_RS08535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPD17_RS08545	COG4948	Mandelate Racemase Muconate Lactonizing
EPD17_RS08555	COG0385	Bile acid
EPD17_RS08560	COG1070	Carbohydrate kinase
EPD17_RS08565	COG2207	Transcriptional regulator
EPD17_RS08565	COG4753	response regulator
EPD17_RS08570	COG4206	TonB-dependent receptor
EPD17_RS08570	COG1629	transport
EPD17_RS08580	COG0129	dihydroxy-acid dehydratase activity
EPD17_RS08585	COG3386	PFAM SMP-30 Gluconolaconase
EPD17_RS08595	COG2382	esterase
EPD17_RS08595	COG3693	PFAM glycoside hydrolase, family 10
EPD17_RS08620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPD17_RS08625	COG2226	methyltransferase
EPD17_RS08630	COG4251	negative regulation of phosphorylation
EPD17_RS08640	COG0745	RESPONSE REGULATOR receiver
EPD17_RS08655	COG3781	membrane
EPD17_RS08665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPD17_RS08670	COG0432	Pfam Uncharacterised protein family UPF0047
EPD17_RS08685	COG1596	polysaccharide export
EPD17_RS08690	COG3206	protein involved in exopolysaccharide biosynthesis
EPD17_RS08690	COG0489	protein tyrosine kinase activity
EPD17_RS08705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPD17_RS08775	COG3408	Glycogen debranching enzyme
EPD17_RS08785	COG4251	negative regulation of phosphorylation
EPD17_RS08790	COG2382	esterase
EPD17_RS08805	COG0436	Aminotransferase
EPD17_RS08825	COG2860	membrane
EPD17_RS08840	COG3011	Protein conserved in bacteria
EPD17_RS08850	COG0531	amino acid
EPD17_RS08855	COG1301	dicarboxylic acid transport
EPD17_RS08860	COG0586	Pfam SNARE associated Golgi protein
EPD17_RS08885	COG0488	(ABC) transporter
EPD17_RS08935	COG0071	Belongs to the small heat shock protein (HSP20) family
EPD17_RS08945	COG0460	homoserine dehydrogenase
EPD17_RS08970	COG4585	Histidine kinase
EPD17_RS08975	COG2197	response regulator
EPD17_RS08995	COG2339	peptidase activity
EPD17_RS09040	COG1228	amidohydrolase
EPD17_RS09070	COG4251	negative regulation of phosphorylation
EPD17_RS09075	COG0784	Response regulator, receiver
EPD17_RS09080	COG3842	ATPase activity
EPD17_RS09100	COG2010	Cytochrome c
EPD17_RS09105	COG0348	domain, Protein
EPD17_RS09115	COG0784	Response regulator, receiver
EPD17_RS09120	COG4251	negative regulation of phosphorylation
EPD17_RS09140	COG0156	8-amino-7-oxononanoate synthase activity
EPD17_RS09165	COG0783	Belongs to the Dps family
EPD17_RS09200	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EPD17_RS09205	COG0671	phosphoesterase, PA-phosphatase related
EPD17_RS09210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPD17_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS09270	COG0346	lactoylglutathione lyase activity
EPD17_RS09275	COG2353	YceI-like domain
EPD17_RS09285	COG1082	Xylose isomerase domain protein TIM barrel
EPD17_RS09305	COG0366	Alpha amylase catalytic
EPD17_RS09325	COG4677	pectinesterase activity
EPD17_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS09335	COG1501	Belongs to the glycosyl hydrolase 31 family
EPD17_RS09340	COG3250	beta-galactosidase activity
EPD17_RS09350	COG0281	malic enzyme
EPD17_RS09350	COG0280	phosphate acetyltransferase
EPD17_RS09355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPD17_RS09365	COG3938	Belongs to the proline racemase family
EPD17_RS09370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPD17_RS09390	COG1506	peptidase
EPD17_RS09390	COG0823	Involved in the tonB-independent uptake of proteins
EPD17_RS09390	COG4946	Tricorn protease homolog
EPD17_RS09400	COG1629	transport
EPD17_RS09405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPD17_RS09420	COG0531	amino acid
EPD17_RS09445	COG3005	denitrification pathway
EPD17_RS09460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPD17_RS09460	COG1333	cytochrome c biogenesis protein
EPD17_RS09475	COG4771	TonB-dependent receptor
EPD17_RS09495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPD17_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS09520	COG1678	Uncharacterized ACR, COG1678
EPD17_RS09530	COG4771	TonB-dependent receptor
EPD17_RS09535	COG4771	TonB-dependent receptor
EPD17_RS09540	COG0702	epimerase
EPD17_RS09560	COG2855	membrane
EPD17_RS09585	COG2989	Protein conserved in bacteria
EPD17_RS09595	COG1132	(ABC) transporter
EPD17_RS09710	COG3250	beta-galactosidase activity
EPD17_RS09720	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS09720	COG3347	Dehydrogenase
EPD17_RS09725	COG4952	isomerase
EPD17_RS09755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPD17_RS09765	COG0823	Involved in the tonB-independent uptake of proteins
EPD17_RS09785	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EPD17_RS09795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPD17_RS09800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPD17_RS09805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPD17_RS09810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPD17_RS09815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EPD17_RS09820	COG0202	RNA polymerase activity
EPD17_RS09825	COG0203	ribosomal protein L17
EPD17_RS09835	COG0505	Belongs to the CarA family
EPD17_RS09850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPD17_RS09855	COG1289	transmembrane transporter activity
EPD17_RS09870	COG0539	negative regulation of cytoplasmic translation
EPD17_RS09895	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPD17_RS09900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPD17_RS09910	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPD17_RS09930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPD17_RS09930	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EPD17_RS09945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPD17_RS09950	COG3876	Protein conserved in bacteria
EPD17_RS09955	COG1047	Peptidyl-prolyl cis-trans
EPD17_RS09965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPD17_RS09970	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPD17_RS09985	COG0848	biopolymer transport protein
EPD17_RS10000	COG2890	protein-(glutamine-N5) methyltransferase activity
EPD17_RS10005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPD17_RS10005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPD17_RS10010	COG0697	spore germination
EPD17_RS10015	COG1739	Uncharacterized protein family UPF0029
EPD17_RS10020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPD17_RS10065	COG2267	carboxylic ester hydrolase activity
EPD17_RS10070	COG0456	acetyltransferase
EPD17_RS10075	COG0045	succinate-CoA ligase (ADP-forming) activity
EPD17_RS10080	COG1127	ABC transporter
EPD17_RS10085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPD17_RS10090	COG0281	malic enzyme
EPD17_RS10090	COG0280	phosphate acetyltransferase
EPD17_RS10105	COG1473	amidohydrolase
EPD17_RS10115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EPD17_RS10120	COG1228	amidohydrolase
EPD17_RS10125	COG1228	amidohydrolase
EPD17_RS10140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EPD17_RS10150	COG0653	protein targeting
EPD17_RS10160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPD17_RS10165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EPD17_RS10170	COG0019	diaminopimelate decarboxylase activity
EPD17_RS10175	COG4251	negative regulation of phosphorylation
EPD17_RS10220	COG1045	serine acetyltransferase
EPD17_RS10240	COG0126	phosphoglycerate kinase activity
EPD17_RS10245	COG1704	LemA family
EPD17_RS10270	COG0101	tRNA pseudouridine synthase activity
EPD17_RS10325	COG4771	TonB-dependent receptor
EPD17_RS10340	COG0268	Binds directly to 16S ribosomal RNA
EPD17_RS10350	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPD17_RS10380	COG0482	sulfurtransferase activity
EPD17_RS10385	COG1312	Catalyzes the dehydration of D-mannonate
EPD17_RS10390	COG3693	PFAM glycoside hydrolase, family 10
EPD17_RS10395	COG3250	beta-galactosidase activity
EPD17_RS10405	COG4771	TonB-dependent receptor
EPD17_RS10410	COG1609	Transcriptional regulator
EPD17_RS10415	COG3661	Belongs to the glycosyl hydrolase 67 family
EPD17_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS10435	COG2211	Major facilitator Superfamily
EPD17_RS10485	COG0527	aspartate kinase activity
EPD17_RS10490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPD17_RS10495	COG1393	Belongs to the ArsC family
EPD17_RS10505	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EPD17_RS10510	COG0154	amidase activity
EPD17_RS10520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EPD17_RS10540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPD17_RS10540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPD17_RS10570	COG0405	Gamma-glutamyltransferase
EPD17_RS10620	COG4172	Belongs to the ABC transporter superfamily
EPD17_RS10640	COG4974	Belongs to the 'phage' integrase family
EPD17_RS10650	COG0792	nuclease activity
EPD17_RS10655	COG1482	cell wall glycoprotein biosynthetic process
EPD17_RS10665	COG0328	RNA-DNA hybrid ribonuclease activity
EPD17_RS10670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPD17_RS10680	COG4251	negative regulation of phosphorylation
EPD17_RS10690	COG0165	Argininosuccinate lyase
EPD17_RS10695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPD17_RS10700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPD17_RS10705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPD17_RS10710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPD17_RS10715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPD17_RS10720	COG0137	argininosuccinate synthase activity
EPD17_RS10735	COG0303	'Molybdopterin
EPD17_RS10750	COG0746	molybdenum cofactor guanylyltransferase activity
EPD17_RS10760	COG0243	molybdopterin cofactor binding
EPD17_RS10765	COG2223	nitrite transmembrane transporter activity
EPD17_RS10770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPD17_RS10770	COG2146	nitrite reductase [NAD(P)H] activity
EPD17_RS10775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPD17_RS10780	COG1648	precorrin-2 dehydrogenase activity
EPD17_RS10780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPD17_RS10785	COG0673	inositol 2-dehydrogenase activity
EPD17_RS10800	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EPD17_RS10805	COG4181	ATPase activity
EPD17_RS10820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPD17_RS10860	COG2814	Major facilitator Superfamily
EPD17_RS10865	COG3292	Two component regulator propeller
EPD17_RS10865	COG0745	RESPONSE REGULATOR receiver
EPD17_RS10865	COG2205	protein histidine kinase activity
EPD17_RS10885	COG2382	esterase
EPD17_RS10895	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD17_RS10910	COG1629	transport
EPD17_RS10915	COG0561	phosphatase activity
EPD17_RS10920	COG1629	transport
EPD17_RS10925	COG0702	epimerase
EPD17_RS10935	COG2382	esterase
EPD17_RS10935	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD17_RS10935	COG3693	PFAM glycoside hydrolase, family 10
EPD17_RS10945	COG1063	alcohol dehydrogenase
EPD17_RS10950	COG2755	lipolytic protein G-D-S-L family
EPD17_RS10950	COG0657	acetylesterase activity
EPD17_RS10955	COG2382	esterase
EPD17_RS10960	COG2382	esterase
EPD17_RS10965	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD17_RS10965	COG3693	PFAM glycoside hydrolase, family 10
EPD17_RS10965	COG2382	esterase
EPD17_RS10975	COG1629	transport
EPD17_RS10980	COG0673	inositol 2-dehydrogenase activity
EPD17_RS10995	COG0697	spore germination
EPD17_RS11000	COG2171	N-acyltransferase activity
EPD17_RS11010	COG0009	L-threonylcarbamoyladenylate synthase
EPD17_RS11015	COG0617	tRNA 3'-terminal CCA addition
EPD17_RS11015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EPD17_RS11015	COG0517	IMP dehydrogenase activity
EPD17_RS11025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPD17_RS11040	COG0442	prolyl-tRNA aminoacylation
EPD17_RS11045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPD17_RS11055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPD17_RS11060	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPD17_RS11080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPD17_RS11085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPD17_RS11090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EPD17_RS11105	COG0131	Imidazoleglycerol-phosphate dehydratase
EPD17_RS11105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPD17_RS11110	COG0753	catalase activity
EPD17_RS11120	COG2388	GCN5-related N-acetyl-transferase
EPD17_RS11125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPD17_RS11130	COG0512	Glutamine amidotransferase of anthranilate synthase
EPD17_RS11135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPD17_RS11140	COG0134	indole-3-glycerol-phosphate synthase activity
EPD17_RS11145	COG0135	phosphoribosylanthranilate isomerase activity
EPD17_RS11150	COG0133	tryptophan synthase activity
EPD17_RS11155	COG0159	tryptophan synthase activity
EPD17_RS11165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPD17_RS11175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPD17_RS11180	COG0107	imidazoleglycerol-phosphate synthase activity
EPD17_RS11185	COG0140	phosphoribosyl-ATP diphosphatase activity
EPD17_RS11185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPD17_RS11190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPD17_RS11195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPD17_RS11240	COG0525	valine-tRNA ligase activity
EPD17_RS11255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPD17_RS11260	COG2610	gluconate transmembrane transporter activity
EPD17_RS11280	COG0110	maltose O-acetyltransferase activity
EPD17_RS11320	COG1253	flavin adenine dinucleotide binding
EPD17_RS11325	COG0671	phosphoesterase, PA-phosphatase related
EPD17_RS11335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPD17_RS11340	COG1104	cysteine desulfurase activity
EPD17_RS11365	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EPD17_RS11370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPD17_RS11395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPD17_RS11420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPD17_RS11425	COG0667	Aldo Keto reductase
EPD17_RS11450	COG1538	Outer membrane efflux protein
EPD17_RS11455	COG0662	Cupin 2, conserved barrel domain protein
EPD17_RS11470	COG1858	cytochrome C peroxidase
EPD17_RS11475	COG0546	phosphoglycolate phosphatase activity
EPD17_RS11510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD17_RS11510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EPD17_RS11520	COG0316	Belongs to the HesB IscA family
EPD17_RS11525	COG0475	glutathione-regulated potassium exporter activity
EPD17_RS11530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPD17_RS11535	COG0436	Aminotransferase
EPD17_RS11540	COG0237	dephospho-CoA kinase activity
EPD17_RS11545	COG1862	Preprotein translocase
EPD17_RS11555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPD17_RS11570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPD17_RS11575	COG0459	protein refolding
EPD17_RS11590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPD17_RS11595	COG2514	catechol 2,3-dioxygenase activity
EPD17_RS11600	COG0720	synthase
EPD17_RS11615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EPD17_RS11620	COG2086	electron transfer activity
EPD17_RS11630	COG0037	tRNA processing
EPD17_RS11640	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EPD17_RS11670	COG0673	inositol 2-dehydrogenase activity
EPD17_RS11680	COG1082	Xylose isomerase domain protein TIM barrel
EPD17_RS11690	COG0673	inositol 2-dehydrogenase activity
EPD17_RS11720	COG0205	6-phosphofructokinase activity
EPD17_RS11745	COG1132	(ABC) transporter
EPD17_RS11775	COG1666	GTP binding
EPD17_RS11780	COG0254	rRNA binding
EPD17_RS11785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EPD17_RS11795	COG0149	triose-phosphate isomerase activity
EPD17_RS11805	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPD17_RS11825	COG4771	TonB-dependent receptor
EPD17_RS11830	COG1349	DNA-binding transcription factor activity
EPD17_RS11845	COG0681	Belongs to the peptidase S26 family
EPD17_RS11855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPD17_RS11860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPD17_RS11895	COG0633	Ferredoxin
EPD17_RS11915	COG0424	maF-like protein
EPD17_RS11935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPD17_RS11950	COG2169	Transcriptional regulator
EPD17_RS11960	COG1940	carbohydrate kinase activity
EPD17_RS11965	COG0738	Major facilitator superfamily
EPD17_RS11970	COG0297	glycogen (starch) synthase activity
EPD17_RS11975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPD17_RS11985	COG0366	Alpha amylase catalytic
EPD17_RS12005	COG0673	inositol 2-dehydrogenase activity
EPD17_RS12010	COG2211	Major facilitator Superfamily
EPD17_RS12015	COG2986	histidine ammonia-lyase
EPD17_RS12025	COG0010	Belongs to the arginase family
EPD17_RS12030	COG0488	(ABC) transporter
EPD17_RS12050	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EPD17_RS12065	COG1022	Amp-dependent synthetase and ligase
EPD17_RS12075	COG0657	acetylesterase activity
EPD17_RS12075	COG2755	lipolytic protein G-D-S-L family
EPD17_RS12120	COG1309	transcriptional regulator
EPD17_RS12135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPD17_RS12135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPD17_RS12140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPD17_RS12150	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EPD17_RS12160	COG1741	Belongs to the pirin family
EPD17_RS12170	COG1253	flavin adenine dinucleotide binding
EPD17_RS12175	COG1522	sequence-specific DNA binding
EPD17_RS12180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPD17_RS12185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EPD17_RS12205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPD17_RS12240	COG0438	transferase activity, transferring glycosyl groups
EPD17_RS12245	COG0438	transferase activity, transferring glycosyl groups
EPD17_RS12255	COG1442	glycosyl transferase family 8
EPD17_RS12255	COG1216	Glycosyl transferase, family 2
EPD17_RS12270	COG1216	Glycosyl transferase, family 2
EPD17_RS12275	COG1216	Glycosyl transferase, family 2
EPD17_RS12300	COG0010	Belongs to the arginase family
EPD17_RS12310	COG1196	nuclear chromosome segregation
EPD17_RS12330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPD17_RS12335	COG1193	negative regulation of DNA recombination
EPD17_RS12340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPD17_RS12340	COG0517	IMP dehydrogenase activity
EPD17_RS12365	COG1566	PFAM secretion protein HlyD family protein
EPD17_RS12380	COG2130	NADP-dependent
EPD17_RS12410	COG3844	kynureninase activity
EPD17_RS12415	COG0284	orotidine-5'-phosphate decarboxylase activity
EPD17_RS12420	COG1506	peptidase
EPD17_RS12420	COG0823	Involved in the tonB-independent uptake of proteins
EPD17_RS12435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EPD17_RS12445	COG1475	DNA binding
EPD17_RS12455	COG1192	Involved in chromosome partitioning
EPD17_RS12460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPD17_RS12465	COG1408	metallophosphoesterase
EPD17_RS12480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPD17_RS12490	COG1363	Peptidase, m42
EPD17_RS12530	COG0631	protein serine/threonine phosphatase activity
EPD17_RS12545	COG0515	serine threonine protein kinase
EPD17_RS12545	COG2815	serine threonine protein kinase
EPD17_RS12560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPD17_RS12565	COG2363	Small membrane protein
EPD17_RS12570	COG1674	ftsk spoiiie
EPD17_RS12580	COG0018	arginyl-trna synthetase
EPD17_RS12595	COG0443	Heat shock 70 kDa protein
EPD17_RS12600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EPD17_RS12610	COG2153	protein acetylation
EPD17_RS12620	COG1960	acyl-CoA dehydrogenase activity
EPD17_RS12630	COG2823	Periplasmic or secreted lipoprotein
EPD17_RS12630	COG1652	LysM domain
EPD17_RS12640	COG1254	Belongs to the acylphosphatase family
EPD17_RS12660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EPD17_RS12685	COG1760	l-serine dehydratase
EPD17_RS12690	COG1335	isochorismatase
EPD17_RS12705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPD17_RS12715	COG1538	Outer membrane efflux protein
EPD17_RS12725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPD17_RS12795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPD17_RS12800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPD17_RS12805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPD17_RS12805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPD17_RS12810	COG1085	galactose-1-phosphate uridylyltransferase
EPD17_RS12820	COG4251	negative regulation of phosphorylation
EPD17_RS12825	COG2201	protein-glutamate methylesterase activity
EPD17_RS12835	COG2116	formate transmembrane transporter activity
EPD17_RS12845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPD17_RS12850	COG0280	phosphate acetyltransferase
EPD17_RS12850	COG0857	belongs to the CobB CobQ family
EPD17_RS12855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPD17_RS12885	COG2755	lipolytic protein G-D-S-L family
EPD17_RS12900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPD17_RS12915	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPD17_RS12930	COG2204	response regulator
EPD17_RS12935	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPD17_RS12935	COG0022	dehydrogenase e1 component
EPD17_RS12940	COG4095	Psort location CytoplasmicMembrane, score
EPD17_RS12945	COG0183	Belongs to the thiolase family
EPD17_RS12950	COG0788	formyltetrahydrofolate deformylase activity
EPD17_RS12965	COG0247	lactate metabolic process
EPD17_RS12970	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EPD17_RS12980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EPD17_RS12985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPD17_RS13000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EPD17_RS13005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPD17_RS13010	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EPD17_RS13015	COG0784	Response regulator, receiver
EPD17_RS13020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPD17_RS13030	COG0463	Glycosyl transferase, family 2
EPD17_RS13045	COG0481	GTPase activity
EPD17_RS13050	COG0438	transferase activity, transferring glycosyl groups
EPD17_RS13065	COG0700	Nucleoside recognition
EPD17_RS13085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPD17_RS13090	COG1053	succinate dehydrogenase
EPD17_RS13115	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPD17_RS13125	COG0793	Belongs to the peptidase S41A family
EPD17_RS13135	COG1595	DNA-templated transcription, initiation
EPD17_RS13145	COG2183	response to ionizing radiation
EPD17_RS13160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPD17_RS13165	COG0191	fructose-bisphosphate aldolase activity
EPD17_RS13175	COG0668	transmembrane transport
EPD17_RS13180	COG4993	Dehydrogenase
EPD17_RS13195	COG0247	lactate metabolic process
EPD17_RS13195	COG2181	nitrate reductase activity
EPD17_RS13205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPD17_RS13230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPD17_RS13235	COG1295	ribonuclease BN
EPD17_RS13240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPD17_RS13250	COG0784	Response regulator, receiver
EPD17_RS13255	COG4251	negative regulation of phosphorylation
EPD17_RS13265	COG2204	response regulator
EPD17_RS13295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPD17_RS13310	COG4251	negative regulation of phosphorylation
EPD17_RS13335	COG4680	protein conserved in bacteria
EPD17_RS13365	COG0601	transmembrane transport
EPD17_RS13385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPD17_RS13400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EPD17_RS13405	COG0105	UTP biosynthetic process
EPD17_RS13415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EPD17_RS13430	COG4948	Mandelate Racemase Muconate Lactonizing
EPD17_RS13435	COG1640	4-alpha-glucanotransferase
EPD17_RS13440	COG3239	Fatty acid desaturase
EPD17_RS13445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EPD17_RS13455	COG1138	Cytochrome C-type biogenesis protein
EPD17_RS13465	COG0010	Belongs to the arginase family
EPD17_RS13480	COG0697	spore germination
EPD17_RS13500	COG0494	nUDIX hydrolase
EPD17_RS13515	COG1131	(ABC) transporter
EPD17_RS13520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPD17_RS13525	COG1956	GAF domain-containing protein
EPD17_RS13545	COG1193	negative regulation of DNA recombination
EPD17_RS13555	COG0531	amino acid
EPD17_RS13565	COG0557	exoribonuclease II activity
EPD17_RS13570	COG1663	tetraacyldisaccharide 4'-kinase activity
EPD17_RS13575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPD17_RS13590	COG0534	Mate efflux family protein
EPD17_RS13605	COG0492	ferredoxin-NADP+ reductase activity
EPD17_RS13615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPD17_RS13650	COG1166	arginine decarboxylase activity
EPD17_RS13655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EPD17_RS13660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPD17_RS13685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPD17_RS13695	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EPD17_RS13715	COG0438	transferase activity, transferring glycosyl groups
EPD17_RS13720	COG0438	transferase activity, transferring glycosyl groups
EPD17_RS13735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPD17_RS13740	COG1216	Glycosyl transferase, family 2
EPD17_RS13740	COG0463	Glycosyl transferase, family 2
EPD17_RS13770	COG0673	inositol 2-dehydrogenase activity
EPD17_RS13785	COG1629	transport
EPD17_RS13800	COG0489	protein tyrosine kinase activity
EPD17_RS13825	COG0655	NAD(P)H dehydrogenase (quinone) activity
EPD17_RS13865	COG0542	response to heat
EPD17_RS13885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPD17_RS13905	COG1595	DNA-templated transcription, initiation
EPD17_RS13920	COG0616	signal peptide processing
EPD17_RS13925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPD17_RS13955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPD17_RS13960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EPD17_RS13970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPD17_RS13975	COG0287	Prephenate dehydrogenase
EPD17_RS13980	COG0436	Aminotransferase
EPD17_RS14015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPD17_RS14025	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EPD17_RS14035	COG0321	lipoyl(octanoyl) transferase activity
EPD17_RS14040	COG0564	pseudouridine synthase activity
EPD17_RS14050	COG0242	peptide deformylase activity
EPD17_RS14055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPD17_RS14060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPD17_RS14070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPD17_RS14080	COG2239	Acts as a magnesium transporter
EPD17_RS14085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPD17_RS14090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EPD17_RS14100	COG1160	GTP binding
EPD17_RS14105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPD17_RS14125	COG0425	Belongs to the sulfur carrier protein TusA family
EPD17_RS14125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPD17_RS14130	COG0515	serine threonine protein kinase
EPD17_RS14130	COG2815	serine threonine protein kinase
EPD17_RS14135	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPD17_RS14140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPD17_RS14165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPD17_RS14205	COG0538	isocitrate dehydrogenase activity
EPD17_RS14210	COG2197	response regulator
EPD17_RS14215	COG3851	Histidine kinase
EPD17_RS14240	COG0433	COG0433 Predicted ATPase
EPD17_RS14250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EPD17_RS14255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPD17_RS14275	COG4771	TonB-dependent receptor
EPD17_RS14290	COG0583	DNA-binding transcription factor activity
EPD17_RS14300	COG3851	Histidine kinase
EPD17_RS14305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD17_RS14310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPD17_RS14315	COG0358	DNA primase activity
EPD17_RS14335	COG1091	dTDP-4-dehydrorhamnose reductase activity
EPD17_RS14355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPD17_RS14360	COG2264	protein methyltransferase activity
EPD17_RS14365	COG1185	polyribonucleotide nucleotidyltransferase activity
EPD17_RS14370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPD17_RS14390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPD17_RS14395	COG0494	nUDIX hydrolase
EPD17_RS14400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPD17_RS14410	COG0297	glycogen (starch) synthase activity
EPD17_RS14415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPD17_RS14420	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EPD17_RS14430	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPD17_RS14435	COG0248	Ppx GppA phosphatase
EPD17_RS14440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPD17_RS14445	COG4206	TonB-dependent receptor
EPD17_RS14450	COG1012	belongs to the aldehyde dehydrogenase family
EPD17_RS14470	COG0793	Belongs to the peptidase S41A family
EPD17_RS14490	COG2217	Heavy metal translocating P-type atpase
EPD17_RS14500	COG0798	PFAM Bile acid sodium symporter
EPD17_RS14515	COG2226	methyltransferase
EPD17_RS14545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPD17_RS14575	COG0668	transmembrane transport
EPD17_RS14625	COG0667	Aldo Keto reductase
EPD17_RS14630	COG0662	Cupin 2, conserved barrel domain protein
EPD17_RS14630	COG2207	Transcriptional regulator
EPD17_RS14660	COG0732	type I restriction modification DNA specificity domain
EPD17_RS14715	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPD17_RS14720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPD17_RS14755	COG2217	Heavy metal translocating P-type atpase
EPD17_RS14785	COG2884	Cell division ATP-binding protein ftsE
EPD17_RS14805	COG0196	riboflavin kinase activity
EPD17_RS14825	COG4771	TonB-dependent receptor
EPD17_RS14830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPD17_RS14840	COG1054	Belongs to the UPF0176 family
EPD17_RS14860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPD17_RS14870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPD17_RS14880	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EPD17_RS14885	COG2181	nitrate reductase activity
EPD17_RS14885	COG0247	lactate metabolic process
EPD17_RS14890	COG0667	Aldo Keto reductase
EPD17_RS14900	COG1073	alpha beta
EPD17_RS14915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPD17_RS14930	COG0730	response to heat
EPD17_RS14935	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPD17_RS14950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPD17_RS14970	COG0747	negative chemotaxis
EPD17_RS14985	COG0791	NLP P60 protein
EPD17_RS15000	COG2211	Major facilitator Superfamily
EPD17_RS15005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EPD17_RS15045	COG4654	Cytochrome c, class I
EPD17_RS15065	COG1629	transport
EPD17_RS15080	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EPD17_RS15085	COG1105	Belongs to the carbohydrate kinase PfkB family
EPD17_RS15090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EPD17_RS15125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPD17_RS15135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPD17_RS15140	COG0540	Belongs to the ATCase OTCase family
EPD17_RS15160	COG1012	belongs to the aldehyde dehydrogenase family
EPD17_RS15210	COG0527	aspartate kinase activity
EPD17_RS15220	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EPD17_RS15225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPD17_RS15230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPD17_RS15235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPD17_RS15245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPD17_RS15255	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EPD17_RS15275	COG0513	Belongs to the DEAD box helicase family
EPD17_RS15280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPD17_RS15285	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPD17_RS15295	COG1595	DNA-templated transcription, initiation
EPD17_RS15300	COG0552	protein localization to endoplasmic reticulum
EPD17_RS15315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EPD17_RS15320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPD17_RS15330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPD17_RS15355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPD17_RS15400	COG1546	Belongs to the CinA family
EPD17_RS15400	COG1058	Belongs to the CinA family
EPD17_RS15405	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPD17_RS15430	COG4555	ABC transporter
EPD17_RS15435	COG0463	Glycosyl transferase, family 2
EPD17_RS15445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPD17_RS15460	COG1765	OsmC-like protein
EPD17_RS15465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPD17_RS15485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPD17_RS15490	COG1648	precorrin-2 dehydrogenase activity
EPD17_RS15490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPD17_RS15505	COG1216	Glycosyl transferase, family 2
EPD17_RS15505	COG0463	Glycosyl transferase, family 2
EPD17_RS15510	COG2226	methyltransferase
EPD17_RS15515	COG0726	polysaccharide deacetylase
EPD17_RS15520	COG1215	transferase activity, transferring glycosyl groups
EPD17_RS15525	COG1215	transferase activity, transferring glycosyl groups
EPD17_RS15540	COG2160	L-arabinose isomerase activity
EPD17_RS15550	COG1069	ribulokinase activity
EPD17_RS15555	COG3958	Transketolase
EPD17_RS15560	COG3959	Transketolase, thiamine diphosphate binding domain
EPD17_RS15565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPD17_RS15570	COG1082	Xylose isomerase domain protein TIM barrel
EPD17_RS15580	COG3507	Belongs to the glycosyl hydrolase 43 family
EPD17_RS15600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPD17_RS15620	COG3158	transport of potassium into the cell
EPD17_RS15630	COG4221	oxidoreductase activity
EPD17_RS15635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPD17_RS15675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPD17_RS15680	COG4771	TonB-dependent receptor
EPD17_RS15700	COG0745	RESPONSE REGULATOR receiver
EPD17_RS15700	COG2205	protein histidine kinase activity
EPD17_RS15700	COG3292	Two component regulator propeller
EPD17_RS15725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EPD17_RS15735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EPD17_RS15740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPD17_RS15750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPD17_RS15755	COG0750	zinc metalloprotease
EPD17_RS15800	COG0415	Belongs to the DNA photolyase family
EPD17_RS15810	COG5002	protein histidine kinase activity
EPD17_RS15810	COG3850	Histidine kinase
EPD17_RS15825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPD17_RS15825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPD17_RS15835	COG0492	ferredoxin-NADP+ reductase activity
EPD17_RS15885	COG5002	protein histidine kinase activity
EPD17_RS15890	COG0745	RESPONSE REGULATOR receiver
EPD17_RS15905	COG1064	alcohol dehydrogenase
EPD17_RS15960	COG2268	Band 7 protein
EPD17_RS15975	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EPD17_RS16000	COG0745	RESPONSE REGULATOR receiver
EPD17_RS16020	COG0475	glutathione-regulated potassium exporter activity
EPD17_RS16020	COG0589	response to stress
EPD17_RS16035	COG0628	permease
EPD17_RS16070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPD17_RS16100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPD17_RS16100	COG1796	DNA polymerase
EPD17_RS16105	COG4191	Histidine kinase
EPD17_RS16110	COG3956	TIGRFAM MazG family protein
EPD17_RS16125	COG1702	phosphate starvation-inducible protein PhoH
EPD17_RS16135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EPD17_RS16145	COG0730	response to heat
EPD17_RS16160	COG4771	TonB-dependent receptor
EPD17_RS16165	COG1321	iron dependent repressor
EPD17_RS16165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPD17_RS16175	COG0439	Biotin carboxylase
EPD17_RS16180	COG0511	ligase activity, forming carbon-carbon bonds
EPD17_RS16185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPD17_RS16195	COG0039	L-malate dehydrogenase activity
EPD17_RS16200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPD17_RS16250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPD17_RS16255	COG0542	response to heat
EPD17_RS16265	COG3001	Fructosamine kinase
EPD17_RS16275	COG4251	negative regulation of phosphorylation
EPD17_RS16280	COG2819	hydrolase of the alpha beta superfamily
EPD17_RS16285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPD17_RS16290	COG0825	malonyl-CoA metabolic process
EPD17_RS16335	COG3275	phosphorelay sensor kinase activity
EPD17_RS16340	COG3275	phosphorelay sensor kinase activity
EPD17_RS16345	COG3279	Response regulator of the LytR AlgR family
EPD17_RS16370	COG4585	Histidine kinase
EPD17_RS16385	COG2378	regulation of single-species biofilm formation
EPD17_RS16400	COG1917	Cupin 2, conserved barrel domain protein
EPD17_RS16400	COG4977	sequence-specific DNA binding
EPD17_RS16430	COG4682	membrane
EPD17_RS16445	COG1477	protein flavinylation
EPD17_RS16450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPD17_RS16465	COG4974	Belongs to the 'phage' integrase family
EPD17_RS16625	COG1252	NADH dehydrogenase
EPD17_RS16630	COG1609	Transcriptional regulator
EPD17_RS16630	COG2207	Transcriptional regulator
EPD17_RS16635	COG0673	inositol 2-dehydrogenase activity
EPD17_RS16640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPD17_RS16655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPD17_RS16670	COG0531	amino acid
EPD17_RS16680	COG2261	transglycosylase associated protein
EPD17_RS16690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EPD17_RS16715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPD17_RS16720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPD17_RS16725	COG0066	3-isopropylmalate dehydratase activity
EPD17_RS16730	COG0473	3-isopropylmalate dehydrogenase activity
EPD17_RS16735	COG0129	dihydroxy-acid dehydratase activity
EPD17_RS16740	COG0028	Belongs to the TPP enzyme family
EPD17_RS16750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPD17_RS16755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPD17_RS16760	COG0069	glutamate synthase activity
EPD17_RS16760	COG0070	glutamate synthase
EPD17_RS16760	COG0067	glutamate synthase
EPD17_RS16770	COG0004	ammonium transporteR
EPD17_RS16780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EPD17_RS16785	COG0460	homoserine dehydrogenase
EPD17_RS16785	COG0527	aspartate kinase activity
EPD17_RS16790	COG0083	homoserine kinase activity
EPD17_RS16795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPD17_RS16805	COG0085	RNA polymerase activity
EPD17_RS16815	COG0222	ribosome binding
EPD17_RS16820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPD17_RS16825	COG0081	regulation of translation
EPD17_RS16830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EPD17_RS16885	COG4974	Belongs to the 'phage' integrase family
EPD17_RS16890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPD17_RS16895	COG0307	riboflavin synthase, alpha
EPD17_RS16900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPD17_RS16900	COG2755	lipolytic protein G-D-S-L family
EPD17_RS16925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPD17_RS16960	COG4771	TonB-dependent receptor
EPD17_RS16980	COG4251	negative regulation of phosphorylation
EPD17_RS16985	COG1091	dTDP-4-dehydrorhamnose reductase activity
EPD17_RS17000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPD17_RS17025	COG1435	thymidine kinase activity
EPD17_RS17055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPD17_RS17070	COG3291	Pkd domain containing protein
EPD17_RS17075	COG0612	Peptidase, M16
EPD17_RS17095	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPD17_RS17100	COG0163	prenyltransferase activity
EPD17_RS17105	COG3250	beta-galactosidase activity
EPD17_RS17110	COG0346	lactoylglutathione lyase activity
EPD17_RS17135	COG0586	Pfam SNARE associated Golgi protein
EPD17_RS17145	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EPD17_RS17150	COG0300	oxidoreductase activity
EPD17_RS17160	COG2217	Heavy metal translocating P-type atpase
EPD17_RS17180	COG0823	Involved in the tonB-independent uptake of proteins
EPD17_RS17180	COG1506	peptidase
EPD17_RS17240	COG1070	Carbohydrate kinase
EPD17_RS17245	COG4977	sequence-specific DNA binding
EPD17_RS17245	COG1917	Cupin 2, conserved barrel domain protein
EPD17_RS17270	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EPD17_RS17290	COG0416	fatty acid biosynthetic process
EPD17_RS17315	COG2226	methyltransferase
EPD17_RS17360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EPD17_RS17395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPD17_RS17400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPD17_RS17410	COG1522	sequence-specific DNA binding
EPD17_RS17415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EPD17_RS17430	COG3546	catalase activity
EPD17_RS17475	COG2197	response regulator
EPD17_RS17490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPD17_RS17505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPD17_RS17515	COG0784	Response regulator, receiver
EPD17_RS17555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPD17_RS17565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPD17_RS17590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPD17_RS17615	COG0047	phosphoribosylformylglycinamidine synthase activity
EPD17_RS17630	COG3158	transport of potassium into the cell
EPD17_RS17655	COG0584	glycerophosphoryl diester phosphodiesterase
EPD17_RS17660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPD17_RS17665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPD17_RS17670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPD17_RS17715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPD17_RS17720	COG1477	protein flavinylation
EPD17_RS17735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPD17_RS17740	COG0739	heme binding
EPD17_RS17755	COG0022	dehydrogenase e1 component
EPD17_RS17760	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPD17_RS17765	COG0193	aminoacyl-tRNA hydrolase activity
EPD17_RS17770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPD17_RS17775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPD17_RS17785	COG2003	Belongs to the UPF0758 family
EPD17_RS17805	COG4771	TonB-dependent receptor
EPD17_RS17820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPD17_RS17825	COG0602	queuosine metabolic process
EPD17_RS17835	COG0758	DNA mediated transformation
EPD17_RS17885	COG4221	oxidoreductase activity
EPD17_RS17915	COG0632	four-way junction helicase activity
EPD17_RS17920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPD17_RS17935	COG2318	DinB family
EPD17_RS17940	COG0626	cystathionine gamma-synthase activity
EPD17_RS17950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EPD17_RS17955	COG0302	gtp cyclohydrolase
EPD17_RS17970	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EPD17_RS17980	COG2197	response regulator
EPD17_RS17985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPD17_RS18055	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EPD17_RS18055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPD17_RS18060	COG0360	Binds together with S18 to 16S ribosomal RNA
EPD17_RS18065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EPD17_RS18070	COG0359	binds to the 23S rRNA
EPD17_RS18075	COG0724	RNA recognition motif
EPD17_RS18090	COG4953	penicillin-binding protein 1C
EPD17_RS18100	COG0519	Catalyzes the synthesis of GMP from XMP
EPD17_RS18100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPD17_RS18115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EPD17_RS18115	COG1793	dna ligase
EPD17_RS18120	COG1793	dna ligase
EPD17_RS18125	COG1858	cytochrome C peroxidase
EPD17_RS18130	COG1201	RNA secondary structure unwinding
EPD17_RS18140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPD17_RS18160	COG1119	ATPase activity
EPD17_RS18165	COG2234	aminopeptidase activity
EPD17_RS18170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPD17_RS18180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EPD17_RS18190	COG2885	chlorophyll binding
EPD17_RS18195	COG0463	Glycosyl transferase, family 2
EPD17_RS18210	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPD17_RS18225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPD17_RS18235	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPD17_RS18315	COG2354	Protein conserved in bacteria
EPD17_RS18335	COG1028	Short-chain dehydrogenase reductase Sdr
EPD17_RS18390	COG3852	Histidine kinase
EPD17_RS18400	COG2204	response regulator
EPD17_RS18405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EPD17_RS18415	COG5487	UPF0391 membrane protein
EPD17_RS18455	COG0006	proline dipeptidase activity
EPD17_RS18460	COG1183	phosphatidylcholine synthase activity
EPD17_RS18470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPD17_RS18485	COG2096	Adenosyltransferase
EPD17_RS18490	COG1136	(ABC) transporter
EPD17_RS18495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPD17_RS18500	COG0180	Tryptophanyl-tRNA synthetase
EPD17_RS18505	COG1428	Deoxynucleoside kinase
EPD17_RS18535	COG0357	Ribosomal RNA small subunit methyltransferase G
EPD17_RS18540	COG1136	(ABC) transporter
EPD17_RS18550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPD17_RS18560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPD17_RS18565	COG0497	DNA recombination
EPD17_RS18575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPD17_RS18580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EPD17_RS18615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPD17_RS18620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPD17_RS18625	COG0484	heat shock protein binding
EPD17_RS18635	COG2304	oxidoreductase activity
EPD17_RS18640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EPD17_RS18655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPD17_RS18695	COG1309	transcriptional regulator
EPD17_RS18700	COG2353	YceI-like domain
EPD17_RS18725	COG0277	FAD linked oxidase domain protein
EPD17_RS18740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPD17_RS18755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPD17_RS18785	COG0423	glycine-tRNA ligase activity
EPD17_RS18795	COG1694	Mazg nucleotide pyrophosphohydrolase
EPD17_RS18810	COG1490	D-aminoacyl-tRNA deacylase activity
EPD17_RS18825	COG1858	cytochrome C peroxidase
EPD17_RS18835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPD17_RS18850	COG4452	Inner membrane protein CreD
EPD17_RS18860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPD17_RS18865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPD17_RS18875	COG1162	GTPase activity
EPD17_RS18900	COG0714	Associated with various cellular activities
EPD17_RS18905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPD17_RS18905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPD17_RS18915	COG2967	ApaG domain
EPD17_RS18920	COG0473	3-isopropylmalate dehydrogenase activity
EPD17_RS18935	COG0023	Translation Initiation Factor
EPD17_RS18945	COG5001	Diguanylate cyclase
EPD17_RS18955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPD17_RS19000	COG3239	Fatty acid desaturase
EPD17_RS19020	COG2201	protein-glutamate methylesterase activity
EPD17_RS19025	COG1404	Belongs to the peptidase S8 family
EPD17_RS19050	COG0702	epimerase
EPD17_RS19055	COG4771	TonB-dependent receptor
EPD17_RS19080	COG0800	Aldolase
EPD17_RS19085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPD17_RS19105	COG4251	negative regulation of phosphorylation
EPD17_RS19115	COG2382	esterase
EPD17_RS19220	COG1309	transcriptional regulator
EPD17_RS19280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EPD17_RS19300	COG0811	peptide transport
EPD17_RS19310	COG1007	ATP synthesis coupled electron transport
EPD17_RS19315	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD17_RS19320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPD17_RS19335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD17_RS19340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EPD17_RS19350	COG1034	ATP synthesis coupled electron transport
EPD17_RS19365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EPD17_RS19370	COG0649	NAD binding
EPD17_RS19375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD17_RS19380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD17_RS19385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPD17_RS19410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPD17_RS19415	COG0124	histidyl-tRNA synthetase
EPD17_RS19420	COG4636	protein conserved in cyanobacteria
EPD17_RS19435	COG0183	Belongs to the thiolase family
EPD17_RS19450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EPD17_RS19460	COG1187	pseudouridine synthase activity
EPD17_RS19465	COG0564	pseudouridine synthase activity
EPD17_RS19485	COG0175	sulfate reduction
EPD17_RS19490	COG0450	alkyl hydroperoxide reductase
EPD17_RS19495	COG1959	2 iron, 2 sulfur cluster binding
EPD17_RS19500	COG1765	OsmC-like protein
EPD17_RS19505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EPD17_RS19510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EPD17_RS19530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPD17_RS19535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPD17_RS19540	COG0228	four-way junction DNA binding
EPD17_RS19545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPD17_RS19575	COG4152	abc transporter atp-binding protein
EPD17_RS19590	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPD17_RS19605	COG1959	2 iron, 2 sulfur cluster binding
EPD17_RS19610	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EPD17_RS19620	COG2205	protein histidine kinase activity
EPD17_RS19635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPD17_RS19640	COG1741	Belongs to the pirin family
EPD17_RS19645	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPD17_RS19675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPD17_RS19690	COG2151	metal-sulfur cluster biosynthetic enzyme
EPD17_RS19705	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EPD17_RS19720	COG0336	Belongs to the RNA methyltransferase TrmD family
EPD17_RS19735	COG3279	Response regulator of the LytR AlgR family
EPD17_RS19750	COG4447	cellulose binding
EPD17_RS19760	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EPD17_RS19775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPD17_RS19785	COG0471	metal ion transport
EPD17_RS19800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity