locus-tag	class	description
BB050_RS00040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BB050_RS00045	COG0280	phosphate acetyltransferase
BB050_RS00045	COG0857	belongs to the CobB CobQ family
BB050_RS00050	COG0598	Magnesium transport protein CorA
BB050_RS00055	COG0443	Heat shock 70 kDa protein
BB050_RS00060	COG0025	NhaP-type Na H and K H
BB050_RS00090	COG2267	carboxylic ester hydrolase activity
BB050_RS00110	COG1119	ATPase activity
BB050_RS00120	COG0564	pseudouridine synthase activity
BB050_RS00130	COG1181	Belongs to the D-alanine--D-alanine ligase family
BB050_RS00140	COG2323	membrane
BB050_RS00145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BB050_RS00150	COG2824	Alkylphosphonate utilization operon protein PhnA
BB050_RS00160	COG0513	Belongs to the DEAD box helicase family
BB050_RS00175	COG1051	belongs to the nudix hydrolase family
BB050_RS00180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BB050_RS00195	COG0799	negative regulation of ribosome biogenesis
BB050_RS00200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB050_RS00210	COG4589	Belongs to the CDS family
BB050_RS00215	COG0688	phosphatidylethanolamine metabolic process
BB050_RS00225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BB050_RS00230	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BB050_RS00235	COG1523	belongs to the glycosyl hydrolase 13 family
BB050_RS00245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BB050_RS00255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BB050_RS00275	COG1764	response to oxidative stress
BB050_RS00290	COG0542	response to heat
BB050_RS00295	COG4067	protein conserved in archaea
BB050_RS00295	COG0189	ligase activity
BB050_RS00305	COG2323	membrane
BB050_RS00315	COG0306	phosphate transporter
BB050_RS00325	COG2986	histidine ammonia-lyase
BB050_RS00335	COG0083	homoserine kinase activity
BB050_RS00340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BB050_RS00390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BB050_RS00395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BB050_RS00400	COG0793	Belongs to the peptidase S41A family
BB050_RS00405	COG0217	transcriptional regulatory protein
BB050_RS00485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BB050_RS00495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BB050_RS00500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB050_RS00510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BB050_RS00530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BB050_RS00545	COG0348	domain, Protein
BB050_RS00560	COG3278	Belongs to the heme-copper respiratory oxidase family
BB050_RS00580	COG3956	TIGRFAM MazG family protein
BB050_RS00590	COG0242	peptide deformylase activity
BB050_RS00595	COG1289	transmembrane transporter activity
BB050_RS00600	COG0579	oxidoreductase
BB050_RS00605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BB050_RS00610	COG0840	transmembrane signaling receptor activity
BB050_RS00630	COG0463	Glycosyl transferase, family 2
BB050_RS00660	COG1216	Glycosyl transferase, family 2
BB050_RS00680	COG1104	cysteine desulfurase activity
BB050_RS00705	COG1045	serine acetyltransferase
BB050_RS00715	COG0667	Aldo Keto reductase
BB050_RS00720	COG2205	protein histidine kinase activity
BB050_RS00725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BB050_RS00740	COG1794	racemase activity, acting on amino acids and derivatives
BB050_RS00750	COG0116	Belongs to the methyltransferase superfamily
BB050_RS00750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BB050_RS00755	COG2226	methyltransferase
BB050_RS00765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BB050_RS00795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BB050_RS00805	COG1858	cytochrome C peroxidase
BB050_RS00815	COG0542	response to heat
BB050_RS00830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BB050_RS00845	COG1295	ribonuclease BN
BB050_RS00860	COG4771	TonB-dependent receptor
BB050_RS00870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BB050_RS00880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BB050_RS00885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB050_RS00910	COG1136	(ABC) transporter
BB050_RS00920	COG0513	Belongs to the DEAD box helicase family
BB050_RS00925	COG2706	6-phosphogluconolactonase activity
BB050_RS00935	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BB050_RS00960	COG1335	isochorismatase
BB050_RS00975	COG1234	tRNA 3'-trailer cleavage
BB050_RS00985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BB050_RS00990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BB050_RS01000	COG1595	DNA-templated transcription, initiation
BB050_RS01005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BB050_RS01055	COG0156	8-amino-7-oxononanoate synthase activity
BB050_RS01075	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BB050_RS01080	COG1959	2 iron, 2 sulfur cluster binding
BB050_RS01090	COG0069	glutamate synthase activity
BB050_RS01105	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BB050_RS01110	COG2205	protein histidine kinase activity
BB050_RS01115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BB050_RS01130	COG2195	Cleaves the N-terminal amino acid of tripeptides
BB050_RS01180	COG0482	sulfurtransferase activity
BB050_RS01205	COG0504	CTP synthase activity
BB050_RS01215	COG3530	Putative quorum-sensing-regulated virulence factor
BB050_RS01220	COG0363	glucosamine-6-phosphate deaminase activity
BB050_RS01250	COG4771	TonB-dependent receptor
BB050_RS01255	COG0702	epimerase
BB050_RS01265	COG3258	Cytochrome c
BB050_RS01275	COG0457	Tetratricopeptide repeat
BB050_RS01285	COG0673	inositol 2-dehydrogenase activity
BB050_RS01305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BB050_RS01305	COG0519	Catalyzes the synthesis of GMP from XMP
BB050_RS01320	COG0484	heat shock protein binding
BB050_RS01335	COG0038	chloride channel
BB050_RS01340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BB050_RS01350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BB050_RS01355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BB050_RS01400	COG3537	Alpha-1,2-mannosidase
BB050_RS01415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BB050_RS01425	COG0174	glutamine synthetase
BB050_RS01500	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BB050_RS01515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB050_RS01515	COG1703	isobutyryl-CoA mutase activity
BB050_RS01515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB050_RS01550	COG0788	formyltetrahydrofolate deformylase activity
BB050_RS01555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BB050_RS01560	COG0284	orotidine-5'-phosphate decarboxylase activity
BB050_RS01565	COG0783	Belongs to the Dps family
BB050_RS01570	COG3237	CsbD-like
BB050_RS01580	COG0784	Response regulator, receiver
BB050_RS01585	COG4251	negative regulation of phosphorylation
BB050_RS01615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BB050_RS01705	COG2223	nitrite transmembrane transporter activity
BB050_RS01740	COG0525	valine-tRNA ligase activity
BB050_RS01755	COG2885	chlorophyll binding
BB050_RS01780	COG0302	gtp cyclohydrolase
BB050_RS01790	COG0215	cysteine-tRNA ligase activity
BB050_RS01795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BB050_RS01800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BB050_RS01855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BB050_RS01860	COG0039	L-malate dehydrogenase activity
BB050_RS01865	COG0187	DNA topoisomerase II activity
BB050_RS01875	COG0367	asparagine synthase
BB050_RS01880	COG0367	asparagine synthase
BB050_RS01890	COG3153	acetyltransferase
BB050_RS01910	COG2884	Cell division ATP-binding protein ftsE
BB050_RS01920	COG1216	Glycosyl transferase, family 2
BB050_RS01920	COG0463	Glycosyl transferase, family 2
BB050_RS01930	COG0438	transferase activity, transferring glycosyl groups
BB050_RS01955	COG2860	membrane
BB050_RS01990	COG0714	Associated with various cellular activities
BB050_RS02010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BB050_RS02015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BB050_RS02025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BB050_RS02030	COG0494	nUDIX hydrolase
BB050_RS02060	COG0517	IMP dehydrogenase activity
BB050_RS02060	COG0516	GMP reductase activity
BB050_RS02090	COG0167	dihydroorotate dehydrogenase activity
BB050_RS02115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BB050_RS02120	COG2195	Cleaves the N-terminal amino acid of tripeptides
BB050_RS02130	COG1862	Preprotein translocase
BB050_RS02135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BB050_RS02145	COG1132	(ABC) transporter
BB050_RS02165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB050_RS02180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BB050_RS02190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BB050_RS02195	COG2814	Major facilitator Superfamily
BB050_RS02235	COG0336	Belongs to the RNA methyltransferase TrmD family
BB050_RS02240	COG0335	large ribosomal subunit rRNA binding
BB050_RS02280	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BB050_RS02300	COG0596	Alpha beta hydrolase
BB050_RS02320	COG4948	Mandelate Racemase Muconate Lactonizing
BB050_RS02325	COG0156	8-amino-7-oxononanoate synthase activity
BB050_RS02335	COG3279	Response regulator of the LytR AlgR family
BB050_RS02350	COG0045	succinate-CoA ligase (ADP-forming) activity
BB050_RS02355	COG0069	glutamate synthase activity
BB050_RS02355	COG0070	glutamate synthase
BB050_RS02355	COG0067	glutamate synthase
BB050_RS02365	COG0019	diaminopimelate decarboxylase activity
BB050_RS02435	COG0606	chelatase, subunit chli
BB050_RS02445	COG0004	ammonium transporteR
BB050_RS02455	COG0037	tRNA processing
BB050_RS02460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BB050_RS02475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BB050_RS02500	COG0531	amino acid
BB050_RS02500	COG0531	amino acid
BB050_RS02505	COG0673	inositol 2-dehydrogenase activity
BB050_RS02510	COG0247	lactate metabolic process
BB050_RS02510	COG0277	FAD linked oxidase domain protein
BB050_RS02525	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BB050_RS02530	COG1649	PFAM Uncharacterised BCR, COG1649
BB050_RS02535	COG2807	transmembrane transport
BB050_RS02550	COG1472	Belongs to the glycosyl hydrolase 3 family
BB050_RS02555	COG0450	alkyl hydroperoxide reductase
BB050_RS02570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BB050_RS02580	COG1674	ftsk spoiiie
BB050_RS02595	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BB050_RS02595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BB050_RS02615	COG4221	oxidoreductase activity
BB050_RS02625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB050_RS02650	COG3537	Alpha-1,2-mannosidase
BB050_RS02655	COG3537	Alpha-1,2-mannosidase
BB050_RS02670	COG4771	TonB-dependent receptor
BB050_RS02785	COG5301	cellulose 1,4-beta-cellobiosidase activity
BB050_RS02805	COG1785	Belongs to the alkaline phosphatase family
BB050_RS02810	COG0702	epimerase
BB050_RS02815	COG4771	TonB-dependent receptor
BB050_RS02830	COG0456	acetyltransferase
BB050_RS02830	COG1846	Transcriptional regulator
BB050_RS02845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS02850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS02860	COG4206	TonB-dependent receptor
BB050_RS02860	COG1629	transport
BB050_RS02880	COG0583	DNA-binding transcription factor activity
BB050_RS02885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BB050_RS02890	COG2115	Belongs to the xylose isomerase family
BB050_RS02895	COG1070	Carbohydrate kinase
BB050_RS02910	COG2211	Major facilitator Superfamily
BB050_RS02920	COG1312	Catalyzes the dehydration of D-mannonate
BB050_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS02930	COG3661	Belongs to the glycosyl hydrolase 67 family
BB050_RS02935	COG1881	PFAM PEBP family protein
BB050_RS02945	COG1609	Transcriptional regulator
BB050_RS02960	COG2197	response regulator
BB050_RS02975	COG2267	carboxylic ester hydrolase activity
BB050_RS03015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BB050_RS03025	COG3655	Transcriptional regulator
BB050_RS03030	COG1131	(ABC) transporter
BB050_RS03040	COG2204	response regulator
BB050_RS03050	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BB050_RS03055	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BB050_RS03060	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BB050_RS03070	COG2205	protein histidine kinase activity
BB050_RS03075	COG5002	protein histidine kinase activity
BB050_RS03080	COG0671	phosphoesterase, PA-phosphatase related
BB050_RS03085	COG1396	sequence-specific DNA binding
BB050_RS03090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BB050_RS03095	COG0587	DNA-directed DNA polymerase activity
BB050_RS03100	COG1199	ATP-dependent helicase activity
BB050_RS03100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BB050_RS03105	COG0708	Exodeoxyribonuclease III
BB050_RS03125	COG0531	amino acid
BB050_RS03130	COG4106	trans-aconitate 2-methyltransferase activity
BB050_RS03135	COG5002	protein histidine kinase activity
BB050_RS03145	COG0791	NLP P60 protein
BB050_RS03160	COG1049	propionate catabolic process, 2-methylcitrate cycle
BB050_RS03165	COG0714	Associated with various cellular activities
BB050_RS03180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BB050_RS03195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BB050_RS03200	COG0085	RNA polymerase activity
BB050_RS03205	COG0222	ribosome binding
BB050_RS03210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BB050_RS03215	COG0081	regulation of translation
BB050_RS03220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BB050_RS03240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BB050_RS03265	COG4974	Belongs to the 'phage' integrase family
BB050_RS03270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BB050_RS03275	COG1960	acyl-CoA dehydrogenase activity
BB050_RS03285	COG0531	amino acid
BB050_RS03300	COG2176	DNA-directed DNA polymerase activity
BB050_RS03315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BB050_RS03325	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BB050_RS03335	COG0321	lipoyl(octanoyl) transferase activity
BB050_RS03350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BB050_RS03360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB050_RS03370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BB050_RS03375	COG0791	NLP P60 protein
BB050_RS03375	COG1388	LysM domain
BB050_RS03380	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BB050_RS03395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BB050_RS03405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BB050_RS03410	COG5520	Belongs to the glycosyl hydrolase 30 family
BB050_RS03465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BB050_RS03470	COG0739	heme binding
BB050_RS03480	COG1704	LemA family
BB050_RS03490	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BB050_RS03495	COG1959	2 iron, 2 sulfur cluster binding
BB050_RS03500	COG4774	siderophore transport
BB050_RS03515	COG1160	GTP binding
BB050_RS03520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BB050_RS03530	COG0514	ATP-dependent DNA helicase (RecQ)
BB050_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS03595	COG0252	asparaginase activity
BB050_RS03680	COG4221	oxidoreductase activity
BB050_RS03715	COG1597	lipid kinase activity
BB050_RS03725	COG0488	(ABC) transporter
BB050_RS03760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BB050_RS03775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BB050_RS03805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BB050_RS03810	COG0459	protein refolding
BB050_RS03820	COG0300	oxidoreductase activity
BB050_RS03830	COG0659	secondary active sulfate transmembrane transporter activity
BB050_RS03845	COG3279	Response regulator of the LytR AlgR family
BB050_RS03895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BB050_RS03915	COG1610	YqeY-like protein
BB050_RS03920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BB050_RS03935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BB050_RS03940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BB050_RS03945	COG0772	Belongs to the SEDS family
BB050_RS03955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BB050_RS03960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BB050_RS03965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BB050_RS03980	COG0275	rRNA processing
BB050_RS03985	COG2001	Belongs to the MraZ family
BB050_RS03995	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BB050_RS04010	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BB050_RS04020	COG0358	DNA primase activity
BB050_RS04050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BB050_RS04080	COG4122	O-methyltransferase activity
BB050_RS04090	COG0671	phosphoesterase, PA-phosphatase related
BB050_RS04095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BB050_RS04125	COG3340	Belongs to the peptidase S51 family
BB050_RS04145	COG2989	Protein conserved in bacteria
BB050_RS04160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BB050_RS04165	COG2733	membrane
BB050_RS04180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BB050_RS04190	COG2967	ApaG domain
BB050_RS04195	COG1012	belongs to the aldehyde dehydrogenase family
BB050_RS04205	COG0357	Ribosomal RNA small subunit methyltransferase G
BB050_RS04210	COG3239	Fatty acid desaturase
BB050_RS04215	COG0436	Aminotransferase
BB050_RS04230	COG0826	peptidase U32
BB050_RS04240	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BB050_RS04255	COG2224	Isocitrate lyase
BB050_RS04260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BB050_RS04275	COG1741	Belongs to the pirin family
BB050_RS04285	COG2353	YceI-like domain
BB050_RS04300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BB050_RS04305	COG0697	spore germination
BB050_RS04310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BB050_RS04350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BB050_RS04360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BB050_RS04375	COG1428	Deoxynucleoside kinase
BB050_RS04380	COG0616	signal peptide processing
BB050_RS04415	COG0560	Phosphoserine phosphatase
BB050_RS04415	COG3830	Belongs to the UPF0237 family
BB050_RS04445	COG1917	Cupin 2, conserved barrel domain protein
BB050_RS04445	COG4977	sequence-specific DNA binding
BB050_RS04450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BB050_RS04460	COG0544	peptidyl-prolyl cis-trans isomerase activity
BB050_RS04465	COG1950	PFAM Membrane protein of
BB050_RS04470	COG0596	Alpha beta hydrolase
BB050_RS04475	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BB050_RS04485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BB050_RS04495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BB050_RS04515	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BB050_RS04545	COG3275	phosphorelay sensor kinase activity
BB050_RS04555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BB050_RS04585	COG3501	Rhs element vgr protein
BB050_RS04595	COG0668	transmembrane transport
BB050_RS04600	COG1214	PFAM Peptidase M22, glycoprotease
BB050_RS04620	COG0577	efflux transmembrane transporter activity
BB050_RS04620	COG1136	(ABC) transporter
BB050_RS04625	COG0577	efflux transmembrane transporter activity
BB050_RS04625	COG1136	(ABC) transporter
BB050_RS04630	COG0577	efflux transmembrane transporter activity
BB050_RS04630	COG1136	(ABC) transporter
BB050_RS04645	COG2322	membrane
BB050_RS04650	COG1999	signal sequence binding
BB050_RS04665	COG1845	cytochrome c oxidase, subunit III
BB050_RS04670	COG1845	cytochrome c oxidase, subunit III
BB050_RS04675	COG0109	protoheme IX farnesyltransferase activity
BB050_RS04685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BB050_RS04695	COG0509	glycine decarboxylation via glycine cleavage system
BB050_RS04705	COG0632	four-way junction helicase activity
BB050_RS04715	COG0517	IMP dehydrogenase activity
BB050_RS04745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BB050_RS04755	COG2255	four-way junction helicase activity
BB050_RS04760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BB050_RS04765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BB050_RS04790	COG0437	4 iron, 4 sulfur cluster binding
BB050_RS04795	COG2010	Cytochrome c
BB050_RS04815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BB050_RS04820	COG2251	uridine kinase activity
BB050_RS04820	COG0195	Participates in both transcription termination and antitermination
BB050_RS04825	COG0779	Required for maturation of 30S ribosomal subunits
BB050_RS04835	COG1012	belongs to the aldehyde dehydrogenase family
BB050_RS04865	COG3118	belongs to the thioredoxin family
BB050_RS04880	COG5002	protein histidine kinase activity
BB050_RS04885	COG0745	RESPONSE REGULATOR receiver
BB050_RS04900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BB050_RS04900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BB050_RS04910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BB050_RS04915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BB050_RS04920	COG0052	Belongs to the universal ribosomal protein uS2 family
BB050_RS04925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BB050_RS04930	COG0339	signal peptide processing
BB050_RS04935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BB050_RS04945	COG0519	Catalyzes the synthesis of GMP from XMP
BB050_RS04965	COG0351	phosphomethylpyrimidine kinase
BB050_RS04970	COG0352	thiamine-phosphate diphosphorylase activity
BB050_RS04975	COG2022	thiamine diphosphate biosynthetic process
BB050_RS04985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BB050_RS04995	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BB050_RS05005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BB050_RS05020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BB050_RS05050	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BB050_RS05055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB050_RS05075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BB050_RS05080	COG1752	Esterase of the alpha-beta hydrolase superfamily
BB050_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS05125	COG1472	Belongs to the glycosyl hydrolase 3 family
BB050_RS05170	COG1629	transport
BB050_RS05185	COG1629	transport
BB050_RS05195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BB050_RS05200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BB050_RS05215	COG0295	cytidine deaminase activity
BB050_RS05220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BB050_RS05270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BB050_RS05275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BB050_RS05280	COG0612	Peptidase, M16
BB050_RS05285	COG0612	Peptidase, M16
BB050_RS05330	COG1194	a g-specific adenine glycosylase
BB050_RS05335	COG0776	regulation of translation
BB050_RS05355	COG4953	penicillin-binding protein 1C
BB050_RS05370	COG0590	tRNA wobble adenosine to inosine editing
BB050_RS05380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BB050_RS05390	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BB050_RS05415	COG1301	dicarboxylic acid transport
BB050_RS05420	COG2226	methyltransferase
BB050_RS05425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BB050_RS05440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BB050_RS05445	COG1410	methionine synthase
BB050_RS05445	COG0646	methionine synthase
BB050_RS05455	COG0492	ferredoxin-NADP+ reductase activity
BB050_RS05465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BB050_RS05465	COG1648	precorrin-2 dehydrogenase activity
BB050_RS05470	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BB050_RS05480	COG0175	sulfate reduction
BB050_RS05490	COG0730	response to heat
BB050_RS05495	COG0730	response to heat
BB050_RS05500	COG1959	2 iron, 2 sulfur cluster binding
BB050_RS05520	COG1765	OsmC-like protein
BB050_RS05525	COG0527	aspartate kinase activity
BB050_RS05525	COG0460	homoserine dehydrogenase
BB050_RS05530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BB050_RS05540	COG0460	homoserine dehydrogenase
BB050_RS05540	COG0527	aspartate kinase activity
BB050_RS05555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BB050_RS05580	COG1428	Deoxynucleoside kinase
BB050_RS05595	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BB050_RS05600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BB050_RS05605	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BB050_RS05620	COG0022	dehydrogenase e1 component
BB050_RS05620	COG0508	dehydrogenase complex catalyzes the overall conversion of
BB050_RS05625	COG2086	electron transfer activity
BB050_RS05630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BB050_RS05640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BB050_RS05655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BB050_RS05660	COG2226	methyltransferase
BB050_RS05680	COG0191	fructose-bisphosphate aldolase activity
BB050_RS05685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BB050_RS05700	COG0138	bifunctional purine biosynthesis protein purh
BB050_RS05720	COG0768	penicillin binding
BB050_RS05725	COG0772	Belongs to the SEDS family
BB050_RS05770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BB050_RS05775	COG1185	polyribonucleotide nucleotidyltransferase activity
BB050_RS05815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BB050_RS05820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BB050_RS05835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BB050_RS05845	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB050_RS05850	COG0791	NLP P60 protein
BB050_RS05855	COG0658	competence protein
BB050_RS05855	COG2333	competence protein COMEC
BB050_RS05870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS05875	COG3104	oligopeptide transport
BB050_RS05880	COG3104	oligopeptide transport
BB050_RS05885	COG0823	Involved in the tonB-independent uptake of proteins
BB050_RS05885	COG1506	peptidase
BB050_RS05905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BB050_RS05910	COG4536	flavin adenine dinucleotide binding
BB050_RS05930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BB050_RS05955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BB050_RS05970	COG1629	transport
BB050_RS05970	COG4206	TonB-dependent receptor
BB050_RS05985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BB050_RS05990	COG1554	hydrolase, family 65, central catalytic
BB050_RS05995	COG1082	Xylose isomerase domain protein TIM barrel
BB050_RS06000	COG0366	Alpha amylase catalytic
BB050_RS06005	COG0366	Alpha amylase catalytic
BB050_RS06010	COG0584	glycerophosphoryl diester phosphodiesterase
BB050_RS06015	COG2081	HI0933 family
BB050_RS06020	COG0546	phosphoglycolate phosphatase activity
BB050_RS06040	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BB050_RS06070	COG1187	pseudouridine synthase activity
BB050_RS06100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BB050_RS06105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BB050_RS06125	COG2315	Protein conserved in bacteria
BB050_RS06150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BB050_RS06155	COG2363	Small membrane protein
BB050_RS06200	COG0270	DNA (cytosine-5-)-methyltransferase activity
BB050_RS06260	COG1917	Cupin 2, conserved barrel domain protein
BB050_RS06260	COG4977	sequence-specific DNA binding
BB050_RS06280	COG0308	aminopeptidase N
BB050_RS06300	COG4206	TonB-dependent receptor
BB050_RS06345	COG0004	ammonium transporteR
BB050_RS06350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BB050_RS06370	COG2204	response regulator
BB050_RS06380	COG1136	(ABC) transporter
BB050_RS06395	COG0489	protein tyrosine kinase activity
BB050_RS06420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BB050_RS06425	COG1970	mechanosensitive ion channel activity
BB050_RS06430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BB050_RS06450	COG4771	TonB-dependent receptor
BB050_RS06455	COG1505	serine-type exopeptidase activity
BB050_RS06460	COG0673	inositol 2-dehydrogenase activity
BB050_RS06475	COG0300	oxidoreductase activity
BB050_RS06480	COG1917	Cupin 2, conserved barrel domain protein
BB050_RS06480	COG4977	sequence-specific DNA binding
BB050_RS06485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BB050_RS06490	COG0066	3-isopropylmalate dehydratase activity
BB050_RS06500	COG0473	3-isopropylmalate dehydrogenase activity
BB050_RS06515	COG0228	four-way junction DNA binding
BB050_RS06520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BB050_RS06530	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BB050_RS06560	COG1960	acyl-CoA dehydrogenase activity
BB050_RS06625	COG1943	Transposase
BB050_RS06635	COG0583	DNA-binding transcription factor activity
BB050_RS06645	COG0252	asparaginase activity
BB050_RS06655	COG0084	hydrolase, TatD family'
BB050_RS06750	COG0567	Dehydrogenase, E1 component
BB050_RS06795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS06800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BB050_RS06805	COG1278	Cold shock
BB050_RS06810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB050_RS06815	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB050_RS06820	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB050_RS06825	COG0649	NAD binding
BB050_RS06830	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BB050_RS06840	COG1034	ATP synthesis coupled electron transport
BB050_RS06845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BB050_RS06850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB050_RS06855	COG0839	Belongs to the complex I subunit 6 family
BB050_RS06860	COG0713	ATP synthesis coupled electron transport
BB050_RS06865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BB050_RS06870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BB050_RS06875	COG1007	ATP synthesis coupled electron transport
BB050_RS06890	COG1012	belongs to the aldehyde dehydrogenase family
BB050_RS06910	COG1619	proteins homologs of microcin C7 resistance protein MccF
BB050_RS06915	COG0792	nuclease activity
BB050_RS06930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BB050_RS06940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BB050_RS06950	COG1404	Belongs to the peptidase S8 family
BB050_RS06960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB050_RS06970	COG0316	Belongs to the HesB IscA family
BB050_RS06975	COG0719	Fe-S assembly protein
BB050_RS06980	COG0396	ATPase activity
BB050_RS06985	COG0719	Fe-S assembly protein
BB050_RS06995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BB050_RS07005	COG2166	iron-sulfur cluster assembly
BB050_RS07010	COG2151	metal-sulfur cluster biosynthetic enzyme
BB050_RS07025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BB050_RS07050	COG0673	inositol 2-dehydrogenase activity
BB050_RS07120	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BB050_RS07165	COG3119	arylsulfatase activity
BB050_RS07180	COG0571	ribonuclease III activity
BB050_RS07185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB050_RS07190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BB050_RS07195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BB050_RS07200	COG0328	RNA-DNA hybrid ribonuclease activity
BB050_RS07210	COG1595	DNA-templated transcription, initiation
BB050_RS07235	COG0193	aminoacyl-tRNA hydrolase activity
BB050_RS07240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BB050_RS07245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BB050_RS07280	COG2160	L-arabinose isomerase activity
BB050_RS07290	COG1069	ribulokinase activity
BB050_RS07315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BB050_RS07320	COG1085	galactose-1-phosphate uridylyltransferase
BB050_RS07335	COG2207	Transcriptional regulator
BB050_RS07340	COG2721	sulfolactate sulfo-lyase activity
BB050_RS07345	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS07350	COG0179	Fumarylacetoacetate (FAA) hydrolase
BB050_RS07370	COG2986	histidine ammonia-lyase
BB050_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS07385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB050_RS07390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BB050_RS07405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BB050_RS07410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BB050_RS07435	COG1131	(ABC) transporter
BB050_RS07440	COG0842	Transport permease protein
BB050_RS07450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB050_RS07470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BB050_RS07475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB050_RS07485	COG0726	polysaccharide deacetylase
BB050_RS07510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BB050_RS07520	COG1215	transferase activity, transferring glycosyl groups
BB050_RS07540	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BB050_RS07565	COG0534	Mate efflux family protein
BB050_RS07575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BB050_RS07600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BB050_RS07605	COG0756	dUTP diphosphatase activity
BB050_RS07620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BB050_RS07625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BB050_RS07630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BB050_RS07635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BB050_RS07640	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BB050_RS07645	COG0356	it plays a direct role in the translocation of protons across the membrane
BB050_RS07670	COG4152	abc transporter atp-binding protein
BB050_RS07695	COG0859	PFAM glycosyl transferase family 9
BB050_RS07705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BB050_RS07720	COG0151	Belongs to the GarS family
BB050_RS07735	COG1215	transferase activity, transferring glycosyl groups
BB050_RS07740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BB050_RS07790	COG1943	Transposase
BB050_RS07805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BB050_RS07820	COG0698	ribose 5-phosphate isomerase
BB050_RS07835	COG0557	exoribonuclease II activity
BB050_RS07885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BB050_RS07885	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BB050_RS07895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BB050_RS07900	COG0445	tRNA wobble uridine modification
BB050_RS07905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BB050_RS07915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BB050_RS07930	COG0758	DNA mediated transformation
BB050_RS07935	COG0180	Tryptophanyl-tRNA synthetase
BB050_RS07950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BB050_RS07960	COG1607	acyl-coa hydrolase
BB050_RS07970	COG0470	DNA polymerase III
BB050_RS08010	COG0126	phosphoglycerate kinase activity
BB050_RS08015	COG1388	LysM domain
BB050_RS08015	COG1705	Flagellar rod assembly protein muramidase FlgJ
BB050_RS08035	COG2885	chlorophyll binding
BB050_RS08040	COG0793	Belongs to the peptidase S41A family
BB050_RS08050	COG0594	ribonuclease P activity
BB050_RS08065	COG1418	mRNA catabolic process
BB050_RS08070	COG2267	carboxylic ester hydrolase activity
BB050_RS08085	COG1999	signal sequence binding
BB050_RS08090	COG3590	peptidase
BB050_RS08100	COG0113	porphobilinogen synthase activity
BB050_RS08115	COG3588	fructose-bisphosphate aldolase
BB050_RS08125	COG0408	coproporphyrinogen oxidase activity
BB050_RS08140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BB050_RS08150	COG0181	hydroxymethylbilane synthase activity
BB050_RS08160	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BB050_RS08180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BB050_RS08190	COG1981	membrane
BB050_RS08195	COG5000	phosphorelay sensor kinase activity
BB050_RS08200	COG1024	Enoyl-CoA hydratase
BB050_RS08215	COG1914	H( )-stimulated, divalent metal cation uptake system
BB050_RS08235	COG4771	TonB-dependent receptor
BB050_RS08275	COG2326	polyphosphate kinase activity
BB050_RS08285	COG0826	peptidase U32
BB050_RS08315	COG1774	PSP1 C-terminal conserved region
BB050_RS08325	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BB050_RS08330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BB050_RS08350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BB050_RS08355	COG4566	intracellular signal transduction
BB050_RS08375	COG0700	Nucleoside recognition
BB050_RS08395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BB050_RS08405	COG0583	DNA-binding transcription factor activity
BB050_RS08425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BB050_RS08425	COG3153	acetyltransferase
BB050_RS08430	COG0629	single-stranded DNA binding
BB050_RS08445	COG1528	Iron-storage protein
BB050_RS08475	COG0697	spore germination
BB050_RS08480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB050_RS08480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BB050_RS08490	COG0384	phenazine biosynthesis protein PhzF
BB050_RS08510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BB050_RS08515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BB050_RS08540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BB050_RS08545	COG2239	Acts as a magnesium transporter
BB050_RS08550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BB050_RS08560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BB050_RS08565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BB050_RS08585	COG3152	Membrane
BB050_RS08595	COG0708	Exodeoxyribonuclease III
BB050_RS08605	COG0667	Aldo Keto reductase
BB050_RS08610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BB050_RS08615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BB050_RS08625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BB050_RS08630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BB050_RS08635	COG0297	glycogen (starch) synthase activity
BB050_RS08645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BB050_RS08660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BB050_RS08675	COG0156	8-amino-7-oxononanoate synthase activity
BB050_RS08715	COG0196	riboflavin kinase activity
BB050_RS08725	COG1040	competence protein
BB050_RS08730	COG0423	glycine-tRNA ligase activity
BB050_RS08735	COG3279	Response regulator of the LytR AlgR family
BB050_RS08745	COG4585	Histidine kinase
BB050_RS08755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BB050_RS08765	COG2318	DinB family
BB050_RS08770	COG2378	regulation of single-species biofilm formation
BB050_RS08780	COG0481	GTPase activity
BB050_RS08795	COG4771	TonB-dependent receptor
BB050_RS08810	COG3250	beta-galactosidase activity
BB050_RS08815	COG1501	Belongs to the glycosyl hydrolase 31 family
BB050_RS08820	COG1082	Xylose isomerase domain protein TIM barrel
BB050_RS08830	COG1472	Belongs to the glycosyl hydrolase 3 family
BB050_RS08855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BB050_RS08865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BB050_RS08870	COG1979	alcohol dehydrogenase
BB050_RS08895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BB050_RS08915	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
BB050_RS08930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BB050_RS08945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BB050_RS08950	COG0194	GDP metabolic process
BB050_RS08955	COG1561	YicC-like family, N-terminal region
BB050_RS08970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BB050_RS08980	COG1629	transport
BB050_RS08985	COG0166	Belongs to the GPI family
BB050_RS09015	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BB050_RS09020	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BB050_RS09025	COG1752	Esterase of the alpha-beta hydrolase superfamily
BB050_RS09030	COG0322	excinuclease ABC activity
BB050_RS09040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BB050_RS09045	COG2304	oxidoreductase activity
BB050_RS09065	COG2304	oxidoreductase activity
BB050_RS09070	COG2304	oxidoreductase activity
BB050_RS09085	COG0714	Associated with various cellular activities
BB050_RS09090	COG4989	oxidoreductase activity
BB050_RS09105	COG4221	oxidoreductase activity
BB050_RS09120	COG0626	cystathionine gamma-synthase activity
BB050_RS09135	COG0745	RESPONSE REGULATOR receiver
BB050_RS09135	COG3292	Two component regulator propeller
BB050_RS09135	COG2205	protein histidine kinase activity
BB050_RS09140	COG1381	Involved in DNA repair and RecF pathway recombination
BB050_RS09155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BB050_RS09180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BB050_RS09185	COG1074	ATP-dependent DNA helicase activity
BB050_RS09195	COG2885	chlorophyll binding
BB050_RS09235	COG0006	proline dipeptidase activity
BB050_RS09255	COG0456	acetyltransferase
BB050_RS09255	COG1214	PFAM Peptidase M22, glycoprotease
BB050_RS09270	COG3425	synthase
BB050_RS09280	COG1053	succinate dehydrogenase
BB050_RS09285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BB050_RS09290	COG1349	DNA-binding transcription factor activity
BB050_RS09295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BB050_RS09315	COG0346	lactoylglutathione lyase activity
BB050_RS09340	COG0307	riboflavin synthase, alpha
BB050_RS09345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BB050_RS09355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BB050_RS09360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BB050_RS09365	COG0511	ligase activity, forming carbon-carbon bonds
BB050_RS09370	COG0439	Biotin carboxylase
BB050_RS09410	COG0823	Involved in the tonB-independent uptake of proteins
BB050_RS09410	COG1506	peptidase
BB050_RS09485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BB050_RS09490	COG0720	synthase
BB050_RS09495	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB050_RS09520	COG2211	Major facilitator Superfamily
BB050_RS09525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BB050_RS09525	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BB050_RS09535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BB050_RS09545	COG1435	thymidine kinase activity
BB050_RS09560	COG0017	Asparaginyl-tRNA synthetase
BB050_RS09575	COG3279	Response regulator of the LytR AlgR family
BB050_RS09580	COG0475	glutathione-regulated potassium exporter activity
BB050_RS09590	COG0233	cytoplasmic translational termination
BB050_RS09595	COG0528	UMP kinase activity
BB050_RS09605	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BB050_RS09610	COG1968	undecaprenyl-diphosphatase activity
BB050_RS09620	COG2177	Part of the ABC transporter FtsEX involved in
BB050_RS09625	COG0495	leucyl-tRNA aminoacylation
BB050_RS09650	COG4585	Histidine kinase
BB050_RS09655	COG2197	response regulator
BB050_RS09665	COG1522	sequence-specific DNA binding
BB050_RS09685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BB050_RS09695	COG1090	epimerase
BB050_RS09705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BB050_RS09730	COG4771	TonB-dependent receptor
BB050_RS09740	COG5002	protein histidine kinase activity
BB050_RS09775	COG4977	sequence-specific DNA binding
BB050_RS09800	COG0527	aspartate kinase activity
BB050_RS09810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BB050_RS09830	COG0793	Belongs to the peptidase S41A family
BB050_RS09855	COG2095	MarC family integral membrane protein
BB050_RS09870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BB050_RS09870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BB050_RS09905	COG0077	Prephenate dehydratase
BB050_RS09910	COG0436	Aminotransferase
BB050_RS09915	COG0287	Prephenate dehydrogenase
BB050_RS09920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BB050_RS09925	COG1162	GTPase activity
BB050_RS09930	COG1490	D-aminoacyl-tRNA deacylase activity
BB050_RS09955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BB050_RS09995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BB050_RS10015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BB050_RS10020	COG0433	COG0433 Predicted ATPase
BB050_RS10035	COG0848	biopolymer transport protein
BB050_RS10040	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BB050_RS10060	COG0602	queuosine metabolic process
BB050_RS10070	COG2813	Specifically methylates the guanine in position
BB050_RS10125	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BB050_RS10145	COG0563	adenylate kinase activity
BB050_RS10160	COG0285	dihydrofolate synthase activity
BB050_RS10165	COG0811	peptide transport
BB050_RS10170	COG0848	biopolymer transport protein
BB050_RS10190	COG1960	acyl-CoA dehydrogenase activity
BB050_RS10200	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS10210	COG1127	ABC transporter
BB050_RS10215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BB050_RS10220	COG1215	transferase activity, transferring glycosyl groups
BB050_RS10235	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BB050_RS10235	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BB050_RS10270	COG1510	regulation of RNA biosynthetic process
BB050_RS10290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BB050_RS10295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BB050_RS10305	COG4772	TonB-dependent receptor
BB050_RS10315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BB050_RS10320	COG0563	adenylate kinase activity
BB050_RS10325	COG1253	flavin adenine dinucleotide binding
BB050_RS10330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BB050_RS10335	COG3591	Belongs to the peptidase S1B family
BB050_RS10345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BB050_RS10350	COG2003	Belongs to the UPF0758 family
BB050_RS10355	COG1011	Hydrolase
BB050_RS10365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BB050_RS10385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BB050_RS10405	COG4206	TonB-dependent receptor
BB050_RS10405	COG1629	transport
BB050_RS10415	COG4771	TonB-dependent receptor
BB050_RS10425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BB050_RS10430	COG0049	tRNA binding
BB050_RS10435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BB050_RS10440	COG0051	transcription antitermination factor activity, RNA binding
BB050_RS10445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BB050_RS10450	COG0088	Forms part of the polypeptide exit tunnel
BB050_RS10455	COG0089	rRNA binding
BB050_RS10460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BB050_RS10465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BB050_RS10470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BB050_RS10475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BB050_RS10480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BB050_RS10485	COG0255	Belongs to the universal ribosomal protein uL29 family
BB050_RS10490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BB050_RS10495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BB050_RS10500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BB050_RS10505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BB050_RS10510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BB050_RS10515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BB050_RS10520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BB050_RS10525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BB050_RS10530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BB050_RS10535	COG1841	ribosomal large subunit assembly
BB050_RS10540	COG0200	Binds to the 23S rRNA
BB050_RS10545	COG0201	protein transport
BB050_RS10550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BB050_RS10555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BB050_RS10560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BB050_RS10565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BB050_RS10570	COG0202	RNA polymerase activity
BB050_RS10575	COG0203	ribosomal protein L17
BB050_RS10580	COG0505	Belongs to the CarA family
BB050_RS10585	COG0148	phosphopyruvate hydratase activity
BB050_RS10605	COG2095	MarC family integral membrane protein
BB050_RS10615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BB050_RS10625	COG0489	protein tyrosine kinase activity
BB050_RS10625	COG3206	protein involved in exopolysaccharide biosynthesis
BB050_RS10635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BB050_RS10640	COG0250	Participates in transcription elongation, termination and antitermination
BB050_RS10645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BB050_RS10680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BB050_RS10690	COG2244	polysaccharide biosynthetic process
BB050_RS10720	COG1216	Glycosyl transferase, family 2
BB050_RS10740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BB050_RS10745	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BB050_RS10750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BB050_RS10765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BB050_RS10775	COG1091	dTDP-4-dehydrorhamnose reductase activity
BB050_RS10810	COG1216	Glycosyl transferase, family 2
BB050_RS10815	COG1216	Glycosyl transferase, family 2
BB050_RS10815	COG0463	Glycosyl transferase, family 2
BB050_RS10820	COG0463	Glycosyl transferase, family 2
BB050_RS10820	COG1216	Glycosyl transferase, family 2
BB050_RS10825	COG0463	Glycosyl transferase, family 2
BB050_RS10825	COG1216	Glycosyl transferase, family 2
BB050_RS10840	COG0463	Glycosyl transferase, family 2
BB050_RS10850	COG1216	Glycosyl transferase, family 2
BB050_RS10855	COG1696	Membrane protein involved in D-alanine export
BB050_RS10865	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BB050_RS10870	COG2089	acid synthase
BB050_RS10915	COG0438	transferase activity, transferring glycosyl groups
BB050_RS10960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BB050_RS10975	COG1183	phosphatidylcholine synthase activity
BB050_RS10990	COG1137	ATPase activity
BB050_RS10995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BB050_RS11000	COG0805	protein transport
BB050_RS11005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BB050_RS11005	COG0517	IMP dehydrogenase activity
BB050_RS11010	COG0514	ATP-dependent DNA helicase (RecQ)
BB050_RS11020	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BB050_RS11040	COG0006	proline dipeptidase activity
BB050_RS11050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB050_RS11055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BB050_RS11060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BB050_RS11070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BB050_RS11075	COG1482	cell wall glycoprotein biosynthetic process
BB050_RS11110	COG0326	Molecular chaperone. Has ATPase activity
BB050_RS11120	COG2885	chlorophyll binding
BB050_RS11155	COG3118	belongs to the thioredoxin family
BB050_RS11160	COG3842	ATPase activity
BB050_RS11165	COG1506	peptidase
BB050_RS11170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BB050_RS11175	COG3142	Participates in the control of copper homeostasis
BB050_RS11185	COG0018	arginyl-trna synthetase
BB050_RS11190	COG1629	transport
BB050_RS11195	COG0702	epimerase
BB050_RS11205	COG4771	TonB-dependent receptor
BB050_RS11220	COG3942	CHAP domain
BB050_RS11220	COG1388	LysM domain
BB050_RS11225	COG1696	Membrane protein involved in D-alanine export
BB050_RS11230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BB050_RS11235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BB050_RS11240	COG0598	Magnesium transport protein CorA
BB050_RS11260	COG1187	pseudouridine synthase activity
BB050_RS11280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BB050_RS11285	COG1663	tetraacyldisaccharide 4'-kinase activity
BB050_RS11300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BB050_RS11305	COG0501	Belongs to the peptidase M48B family
BB050_RS11310	COG0501	Belongs to the peptidase M48B family
BB050_RS11340	COG2808	Putative FMN-binding domain
BB050_RS11345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BB050_RS11365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BB050_RS11375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BB050_RS11380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BB050_RS11410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BB050_RS11420	COG1475	DNA binding
BB050_RS11425	COG1192	Involved in chromosome partitioning
BB050_RS11485	COG2132	Multicopper oxidase
BB050_RS11490	COG2217	Heavy metal translocating P-type atpase
BB050_RS11515	COG2814	Major facilitator Superfamily
BB050_RS11520	COG4771	TonB-dependent receptor
BB050_RS11525	COG0702	epimerase
BB050_RS11550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BB050_RS11565	COG2205	protein histidine kinase activity
BB050_RS11565	COG0745	RESPONSE REGULATOR receiver
BB050_RS11565	COG3292	Two component regulator propeller
BB050_RS11570	COG1629	transport
BB050_RS11595	COG3250	beta-galactosidase activity
BB050_RS11635	COG0456	acetyltransferase
BB050_RS11660	COG1678	Uncharacterized ACR, COG1678
BB050_RS11670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BB050_RS11675	COG0514	ATP-dependent DNA helicase (RecQ)
BB050_RS11700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BB050_RS11705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BB050_RS11715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BB050_RS11735	COG4974	Belongs to the 'phage' integrase family
BB050_RS11745	COG1418	mRNA catabolic process
BB050_RS11760	COG0739	heme binding
BB050_RS11790	COG1132	(ABC) transporter
BB050_RS11795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB050_RS11800	COG0463	Glycosyl transferase, family 2
BB050_RS11810	COG0254	rRNA binding
BB050_RS11825	COG0488	(ABC) transporter
BB050_RS11835	COG0471	metal ion transport
BB050_RS11855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BB050_RS11860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BB050_RS11865	COG4682	membrane
BB050_RS11900	COG4206	TonB-dependent receptor
BB050_RS11910	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BB050_RS11920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BB050_RS11925	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BB050_RS11940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BB050_RS11950	COG1120	ATPase activity
BB050_RS11960	COG1187	pseudouridine synthase activity
BB050_RS11970	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS12010	COG1607	acyl-coa hydrolase
BB050_RS12025	COG1090	epimerase
BB050_RS12035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BB050_RS12040	COG0415	Belongs to the DNA photolyase family
BB050_RS12095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BB050_RS12100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BB050_RS12105	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BB050_RS12110	COG0545	Peptidyl-prolyl cis-trans isomerase
BB050_RS12115	COG3958	Transketolase
BB050_RS12120	COG3959	Transketolase, thiamine diphosphate binding domain
BB050_RS12130	COG0343	queuine tRNA-ribosyltransferase activity
BB050_RS12145	COG0825	malonyl-CoA metabolic process
BB050_RS12150	COG0305	Participates in initiation and elongation during chromosome replication
BB050_RS12170	COG2197	response regulator
BB050_RS12205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BB050_RS12215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BB050_RS12220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BB050_RS12225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BB050_RS12230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BB050_RS12300	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
BB050_RS12305	COG0686	Belongs to the AlaDH PNT family
BB050_RS12320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BB050_RS12325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BB050_RS12335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BB050_RS12345	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB050_RS12345	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB050_RS12350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BB050_RS12365	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS12370	COG0436	Aminotransferase
BB050_RS12390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BB050_RS12395	COG0824	Thioesterase
BB050_RS12400	COG1739	Uncharacterized protein family UPF0029
BB050_RS12405	COG1011	Hydrolase
BB050_RS12410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BB050_RS12410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BB050_RS12415	COG0456	acetyltransferase
BB050_RS12420	COG2890	protein-(glutamine-N5) methyltransferase activity
BB050_RS12425	COG0577	efflux transmembrane transporter activity
BB050_RS12430	COG0124	histidyl-tRNA synthetase
BB050_RS12440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BB050_RS12445	COG0484	heat shock protein binding
BB050_RS12450	COG4152	abc transporter atp-binding protein
BB050_RS12460	COG2204	response regulator
BB050_RS12465	COG0513	Belongs to the DEAD box helicase family
BB050_RS12470	COG1073	alpha beta
BB050_RS12480	COG0561	phosphatase activity
BB050_RS12495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BB050_RS12505	COG0300	oxidoreductase activity
BB050_RS12515	COG2304	oxidoreductase activity
BB050_RS12520	COG4771	TonB-dependent receptor
BB050_RS12540	COG2326	polyphosphate kinase activity
BB050_RS12550	COG3279	Response regulator of the LytR AlgR family
BB050_RS12565	COG0534	Mate efflux family protein
BB050_RS12575	COG1368	sulfuric ester hydrolase activity
BB050_RS12600	COG0450	alkyl hydroperoxide reductase
BB050_RS12605	COG4651	solute:proton antiporter activity
BB050_RS12605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BB050_RS12620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BB050_RS12625	COG0529	Catalyzes the synthesis of activated sulfate
BB050_RS12645	COG0653	protein targeting
BB050_RS12660	COG1136	(ABC) transporter
BB050_RS12680	COG0488	(ABC) transporter
BB050_RS12695	COG4464	protein tyrosine phosphatase activity
BB050_RS12720	COG0508	dehydrogenase complex catalyzes the overall conversion of
BB050_RS12730	COG0179	Fumarylacetoacetate (FAA) hydrolase
BB050_RS12740	COG1058	Belongs to the CinA family
BB050_RS12740	COG1546	Belongs to the CinA family
BB050_RS12745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BB050_RS12750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BB050_RS12760	COG0552	protein localization to endoplasmic reticulum
BB050_RS12780	COG0105	UTP biosynthetic process
BB050_RS12790	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BB050_RS12795	COG0477	Major facilitator Superfamily
BB050_RS12840	COG2755	lipolytic protein G-D-S-L family
BB050_RS12850	COG1472	Belongs to the glycosyl hydrolase 3 family
BB050_RS12860	COG0667	Aldo Keto reductase
BB050_RS12870	COG2942	2-epimerase
BB050_RS12875	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BB050_RS12880	COG2211	Major facilitator Superfamily
BB050_RS12885	COG4124	Belongs to the glycosyl hydrolase 26 family
BB050_RS12890	COG2169	Transcriptional regulator
BB050_RS12895	COG4771	TonB-dependent receptor
BB050_RS12900	COG0561	phosphatase activity
BB050_RS12910	COG3345	alpha-galactosidase
BB050_RS12935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BB050_RS12950	COG0442	prolyl-tRNA aminoacylation
BB050_RS12965	COG0268	Binds directly to 16S ribosomal RNA
BB050_RS12970	COG2201	protein-glutamate methylesterase activity
BB050_RS12975	COG5002	protein histidine kinase activity
BB050_RS12975	COG3850	Histidine kinase
BB050_RS12980	COG1217	gtp-binding protein TYPA
BB050_RS12995	COG1131	(ABC) transporter
BB050_RS13025	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS13030	COG1309	transcriptional regulator
BB050_RS13055	COG0038	chloride channel
BB050_RS13065	COG0346	lactoylglutathione lyase activity
BB050_RS13070	COG0110	maltose O-acetyltransferase activity
BB050_RS13100	COG3275	phosphorelay sensor kinase activity
BB050_RS13125	COG3279	Response regulator of the LytR AlgR family
BB050_RS13135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BB050_RS13135	COG0617	tRNA 3'-terminal CCA addition
BB050_RS13135	COG0517	IMP dehydrogenase activity
BB050_RS13140	COG3022	response to hydroperoxide
BB050_RS13160	COG1309	transcriptional regulator
BB050_RS13165	COG0159	tryptophan synthase activity
BB050_RS13180	COG0133	tryptophan synthase activity
BB050_RS13190	COG0134	indole-3-glycerol-phosphate synthase activity
BB050_RS13195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BB050_RS13200	COG0512	Glutamine amidotransferase of anthranilate synthase
BB050_RS13200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BB050_RS13210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BB050_RS13225	COG0778	Nitroreductase
BB050_RS13235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BB050_RS13255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BB050_RS13255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BB050_RS13265	COG1271	oxidase subunit
BB050_RS13270	COG1294	oxidase, subunit
BB050_RS13290	COG1395	domain, Protein
BB050_RS13305	COG1054	Belongs to the UPF0176 family
BB050_RS13350	COG1538	Outer membrane efflux protein
BB050_RS13380	COG2723	6-phospho-beta-galactosidase activity
BB050_RS13455	COG4251	negative regulation of phosphorylation
BB050_RS13460	COG0784	Response regulator, receiver
BB050_RS13465	COG1215	transferase activity, transferring glycosyl groups
BB050_RS13470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB050_RS13475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BB050_RS13510	COG4771	TonB-dependent receptor
BB050_RS13540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS13545	COG0612	Peptidase, M16
BB050_RS13580	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BB050_RS13600	COG2011	ABC-type metal ion transport system permease component
BB050_RS13605	COG1464	Belongs to the NlpA lipoprotein family
BB050_RS13610	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BB050_RS13630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BB050_RS13640	COG1472	Belongs to the glycosyl hydrolase 3 family
BB050_RS13645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BB050_RS13650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BB050_RS13655	COG3876	Protein conserved in bacteria
BB050_RS13660	COG0702	epimerase
BB050_RS13665	COG4771	TonB-dependent receptor
BB050_RS13670	COG1349	DNA-binding transcription factor activity
BB050_RS13675	COG0277	FAD linked oxidase domain protein
BB050_RS13675	COG0247	lactate metabolic process
BB050_RS13680	COG2382	esterase
BB050_RS13680	COG3693	PFAM glycoside hydrolase, family 10
BB050_RS13690	COG1649	PFAM Uncharacterised BCR, COG1649
BB050_RS13700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BB050_RS13705	COG4206	TonB-dependent receptor
BB050_RS13725	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS13730	COG0723	plastoquinol--plastocyanin reductase activity
BB050_RS13730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB050_RS13745	COG4251	negative regulation of phosphorylation
BB050_RS13750	COG3279	Response regulator of the LytR AlgR family
BB050_RS13755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS13785	COG0628	permease
BB050_RS13795	COG2814	Major facilitator Superfamily
BB050_RS13810	COG1595	DNA-templated transcription, initiation
BB050_RS13820	COG4771	TonB-dependent receptor
BB050_RS13850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BB050_RS13870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BB050_RS13890	COG1393	Belongs to the ArsC family
BB050_RS13905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BB050_RS13905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BB050_RS13910	COG3158	transport of potassium into the cell
BB050_RS13935	COG1595	DNA-templated transcription, initiation
BB050_RS13955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BB050_RS13970	COG0583	DNA-binding transcription factor activity
BB050_RS13990	COG0288	reversible hydration of carbon dioxide
BB050_RS14030	COG1960	acyl-CoA dehydrogenase activity
BB050_RS14040	COG0183	Belongs to the thiolase family
BB050_RS14045	COG1024	Enoyl-CoA hydratase
BB050_RS14045	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB050_RS14070	COG1690	Belongs to the RtcB family
BB050_RS14075	COG0084	hydrolase, TatD family'
BB050_RS14120	COG1022	Amp-dependent synthetase and ligase
BB050_RS14155	COG1169	isochorismate synthase
BB050_RS14160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BB050_RS14170	COG2321	neutral zinc metallopeptidase
BB050_RS14175	COG0784	Response regulator, receiver
BB050_RS14175	COG2205	protein histidine kinase activity
BB050_RS14185	COG1012	belongs to the aldehyde dehydrogenase family
BB050_RS14190	COG0564	pseudouridine synthase activity
BB050_RS14200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BB050_RS14210	COG1760	l-serine dehydratase
BB050_RS14215	COG0475	glutathione-regulated potassium exporter activity
BB050_RS14215	COG0589	response to stress
BB050_RS14255	COG1917	Cupin 2, conserved barrel domain protein
BB050_RS14255	COG2207	Transcriptional regulator
BB050_RS14270	COG2706	6-phosphogluconolactonase activity
BB050_RS14305	COG1917	Cupin 2, conserved barrel domain protein
BB050_RS14305	COG4977	sequence-specific DNA binding
BB050_RS14320	COG2249	NAD(P)H dehydrogenase (quinone) activity
BB050_RS14325	COG3655	Transcriptional regulator
BB050_RS14385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BB050_RS14395	COG3279	Response regulator of the LytR AlgR family
BB050_RS14405	COG0702	epimerase
BB050_RS14410	COG1629	transport
BB050_RS14420	COG3275	phosphorelay sensor kinase activity
BB050_RS14425	COG1132	(ABC) transporter
BB050_RS14430	COG0101	tRNA pseudouridine synthase activity
BB050_RS14460	COG2234	aminopeptidase activity
BB050_RS14475	COG1522	sequence-specific DNA binding
BB050_RS14480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BB050_RS14490	COG2855	membrane
BB050_RS14495	COG3119	arylsulfatase activity
BB050_RS14500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BB050_RS14515	COG0702	epimerase
BB050_RS14520	COG4771	TonB-dependent receptor
BB050_RS14525	COG0303	'Molybdopterin
BB050_RS14535	COG0746	molybdenum cofactor guanylyltransferase activity
BB050_RS14550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BB050_RS14560	COG0521	Mo-molybdopterin cofactor biosynthetic process
BB050_RS14560	COG0315	cyclic pyranopterin monophosphate synthase activity
BB050_RS14580	COG0243	molybdopterin cofactor binding
BB050_RS14635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BB050_RS14650	COG0583	DNA-binding transcription factor activity
BB050_RS14670	COG0667	Aldo Keto reductase
BB050_RS14680	COG0791	NLP P60 protein
BB050_RS14685	COG0183	Belongs to the thiolase family
BB050_RS14760	COG0628	permease
BB050_RS14780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BB050_RS14785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BB050_RS14800	COG0205	6-phosphofructokinase activity
BB050_RS14820	COG0251	oxidation-reduction process
BB050_RS14830	COG1388	LysM domain
BB050_RS14830	COG0860	N-Acetylmuramoyl-L-alanine amidase
BB050_RS14840	COG0247	lactate metabolic process
BB050_RS14840	COG2181	nitrate reductase activity
BB050_RS14845	COG2181	nitrate reductase activity
BB050_RS14845	COG0247	lactate metabolic process
BB050_RS14855	COG0438	transferase activity, transferring glycosyl groups
BB050_RS14875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BB050_RS14880	COG1301	dicarboxylic acid transport
BB050_RS14890	COG0513	Belongs to the DEAD box helicase family
BB050_RS14895	COG0010	Belongs to the arginase family
BB050_RS14905	COG1228	amidohydrolase
BB050_RS14920	COG0300	oxidoreductase activity
BB050_RS14930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BB050_RS14945	COG3279	Response regulator of the LytR AlgR family
BB050_RS14950	COG3275	phosphorelay sensor kinase activity
BB050_RS14955	COG1629	transport
BB050_RS14965	COG0363	glucosamine-6-phosphate deaminase activity
BB050_RS14970	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BB050_RS14975	COG3325	Belongs to the glycosyl hydrolase 18 family
BB050_RS14975	COG3469	chitinase activity
BB050_RS15000	COG0488	(ABC) transporter
BB050_RS15015	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BB050_RS15020	COG0540	Belongs to the ATCase OTCase family
BB050_RS15030	COG1234	tRNA 3'-trailer cleavage
BB050_RS15035	COG0259	pyridoxamine-phosphate oxidase activity
BB050_RS15045	COG3047	cAMP biosynthetic process
BB050_RS15045	COG2885	chlorophyll binding
BB050_RS15065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BB050_RS15070	COG0248	Ppx GppA phosphatase
BB050_RS15095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BB050_RS15115	COG1388	LysM domain
BB050_RS15130	COG1301	dicarboxylic acid transport
BB050_RS15175	COG3384	dioxygenase
BB050_RS15190	COG2226	methyltransferase
BB050_RS15195	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BB050_RS15200	COG0022	dehydrogenase e1 component
BB050_RS15210	COG1611	Belongs to the LOG family
BB050_RS15215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BB050_RS15230	COG0405	Gamma-glutamyltransferase
BB050_RS15240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BB050_RS15250	COG1560	Kdo2-lipid A biosynthetic process
BB050_RS15295	COG1063	alcohol dehydrogenase
BB050_RS15315	COG0477	Major facilitator Superfamily
BB050_RS15340	COG4221	oxidoreductase activity
BB050_RS15345	COG0346	lactoylglutathione lyase activity
BB050_RS15355	COG1472	Belongs to the glycosyl hydrolase 3 family
BB050_RS15375	COG1629	transport
BB050_RS15380	COG0702	epimerase
BB050_RS15395	COG3693	PFAM glycoside hydrolase, family 10
BB050_RS15395	COG3507	Belongs to the glycosyl hydrolase 43 family
BB050_RS15395	COG2382	esterase
BB050_RS15410	COG3507	Belongs to the glycosyl hydrolase 43 family
BB050_RS15415	COG3507	Belongs to the glycosyl hydrolase 43 family
BB050_RS15420	COG1082	Xylose isomerase domain protein TIM barrel
BB050_RS15425	COG4771	TonB-dependent receptor
BB050_RS15435	COG3507	Belongs to the glycosyl hydrolase 43 family
BB050_RS15440	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BB050_RS15445	COG2382	esterase
BB050_RS15445	COG3693	PFAM glycoside hydrolase, family 10
BB050_RS15450	COG2382	esterase
BB050_RS15455	COG2423	ornithine cyclodeaminase activity
BB050_RS15520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS15530	COG0484	heat shock protein binding
BB050_RS15550	COG3012	SEC-C Motif Domain Protein
BB050_RS15565	COG0697	spore germination
BB050_RS15570	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BB050_RS15595	COG1629	transport
BB050_RS15595	COG4206	TonB-dependent receptor
BB050_RS15610	COG1082	Xylose isomerase domain protein TIM barrel
BB050_RS15645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BB050_RS15665	COG1127	ABC transporter
BB050_RS15670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BB050_RS15675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB050_RS15735	COG1538	Outer membrane efflux protein
BB050_RS15770	COG0693	protein deglycase activity
BB050_RS15795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BB050_RS15815	COG3279	Response regulator of the LytR AlgR family
BB050_RS15825	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS15830	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BB050_RS15850	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BB050_RS15855	COG1335	isochorismatase
BB050_RS15865	COG2207	Transcriptional regulator
BB050_RS15870	COG4771	TonB-dependent receptor
BB050_RS15885	COG2755	lipolytic protein G-D-S-L family
BB050_RS15885	COG0657	acetylesterase activity
BB050_RS15895	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BB050_RS15900	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS15905	COG1904	glucuronate isomerase
BB050_RS15915	COG0800	Aldolase
BB050_RS15920	COG0246	Mannitol dehydrogenase
BB050_RS15925	COG2721	sulfolactate sulfo-lyase activity
BB050_RS15930	COG1609	Transcriptional regulator
BB050_RS15940	COG1629	transport
BB050_RS15950	COG0657	acetylesterase activity
BB050_RS15960	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BB050_RS15965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BB050_RS15990	COG2755	lipolytic protein G-D-S-L family
BB050_RS15995	COG3852	Histidine kinase
BB050_RS16015	COG2188	Transcriptional regulator
BB050_RS16025	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS16025	COG3347	Dehydrogenase
BB050_RS16030	COG4952	isomerase
BB050_RS16040	COG0247	lactate metabolic process
BB050_RS16045	COG1139	Iron-sulfur cluster binding protein
BB050_RS16050	COG1556	Lactate utilization protein
BB050_RS16055	COG0745	RESPONSE REGULATOR receiver
BB050_RS16055	COG3292	Two component regulator propeller
BB050_RS16055	COG2205	protein histidine kinase activity
BB050_RS16065	COG4771	TonB-dependent receptor
BB050_RS16070	COG0702	epimerase
BB050_RS16085	COG3250	beta-galactosidase activity
BB050_RS16105	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BB050_RS16115	COG1104	cysteine desulfurase activity
BB050_RS16120	COG2080	2 iron, 2 sulfur cluster binding
BB050_RS16125	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BB050_RS16130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BB050_RS16140	COG3250	beta-galactosidase activity
BB050_RS16145	COG3250	beta-galactosidase activity
BB050_RS16150	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BB050_RS16155	COG0702	epimerase
BB050_RS16160	COG4771	TonB-dependent receptor
BB050_RS16165	COG2205	protein histidine kinase activity
BB050_RS16165	COG3292	Two component regulator propeller
BB050_RS16165	COG0745	RESPONSE REGULATOR receiver
BB050_RS16175	COG1312	Catalyzes the dehydration of D-mannonate
BB050_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS16185	COG0800	Aldolase
BB050_RS16195	COG1609	Transcriptional regulator
BB050_RS16200	COG4677	pectinesterase activity
BB050_RS16205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BB050_RS16240	COG1595	DNA-templated transcription, initiation
BB050_RS16250	COG4771	TonB-dependent receptor
BB050_RS16280	COG1546	Belongs to the CinA family
BB050_RS16280	COG1058	Belongs to the CinA family
BB050_RS16285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BB050_RS16300	COG2133	pyrroloquinoline quinone binding
BB050_RS16310	COG3279	Response regulator of the LytR AlgR family
BB050_RS16315	COG3275	phosphorelay sensor kinase activity
BB050_RS16340	COG0738	Major facilitator superfamily
BB050_RS16360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BB050_RS16375	COG1063	alcohol dehydrogenase
BB050_RS16415	COG2223	nitrite transmembrane transporter activity
BB050_RS16425	COG3119	arylsulfatase activity
BB050_RS16425	COG3408	Glycogen debranching enzyme
BB050_RS16445	COG3940	Belongs to the glycosyl hydrolase 43 family
BB050_RS16475	COG4206	TonB-dependent receptor
BB050_RS16475	COG1629	transport
BB050_RS16525	COG3408	Glycogen debranching enzyme
BB050_RS16545	COG3408	Glycogen debranching enzyme
BB050_RS16575	COG3250	beta-galactosidase activity
BB050_RS16600	COG0363	glucosamine-6-phosphate deaminase activity
BB050_RS16605	COG3279	Response regulator of the LytR AlgR family
BB050_RS16615	COG3537	Alpha-1,2-mannosidase
BB050_RS16625	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BB050_RS16630	COG3693	PFAM glycoside hydrolase, family 10
BB050_RS16640	COG1446	asparaginase
BB050_RS16645	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BB050_RS16665	COG1472	Belongs to the glycosyl hydrolase 3 family
BB050_RS16670	COG4771	TonB-dependent receptor
BB050_RS16690	COG1733	regulation of RNA biosynthetic process
BB050_RS16725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BB050_RS16735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BB050_RS16745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BB050_RS16820	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BB050_RS16825	COG4771	TonB-dependent receptor
BB050_RS16845	COG3537	Alpha-1,2-mannosidase
BB050_RS16850	COG0457	Tetratricopeptide repeat
BB050_RS16855	COG2814	Major facilitator Superfamily
BB050_RS16870	COG1082	Xylose isomerase domain protein TIM barrel
BB050_RS16885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BB050_RS16900	COG4771	TonB-dependent receptor
BB050_RS16930	COG3292	Two component regulator propeller
BB050_RS16930	COG2205	protein histidine kinase activity
BB050_RS16930	COG0745	RESPONSE REGULATOR receiver
BB050_RS16940	COG3250	beta-galactosidase activity
BB050_RS17005	COG3119	arylsulfatase activity
BB050_RS17015	COG2249	NAD(P)H dehydrogenase (quinone) activity
BB050_RS17025	COG0071	Belongs to the small heat shock protein (HSP20) family
BB050_RS17035	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BB050_RS17045	COG1649	PFAM Uncharacterised BCR, COG1649
BB050_RS17060	COG0702	epimerase
BB050_RS17065	COG4771	TonB-dependent receptor
BB050_RS17075	COG1446	asparaginase
BB050_RS17080	COG4242	Belongs to the peptidase S51 family
BB050_RS17085	COG1288	antiporter activity
BB050_RS17110	COG2205	protein histidine kinase activity
BB050_RS17110	COG0784	Response regulator, receiver
BB050_RS17125	COG2259	Doxx family
BB050_RS17160	COG4221	oxidoreductase activity
BB050_RS17170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BB050_RS17190	COG1113	amino acid transport
BB050_RS17205	COG4771	TonB-dependent receptor
BB050_RS17230	COG3279	Response regulator of the LytR AlgR family
BB050_RS17235	COG3275	phosphorelay sensor kinase activity
BB050_RS17385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BB050_RS17390	COG1522	sequence-specific DNA binding
BB050_RS17400	COG1012	belongs to the aldehyde dehydrogenase family
BB050_RS17405	COG3408	Glycogen debranching enzyme
BB050_RS17405	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BB050_RS17415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BB050_RS17420	COG0247	lactate metabolic process
BB050_RS17440	COG4771	TonB-dependent receptor
BB050_RS17455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BB050_RS17465	COG3938	Belongs to the proline racemase family
BB050_RS17470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BB050_RS17475	COG0006	proline dipeptidase activity
BB050_RS17485	COG4771	TonB-dependent receptor
BB050_RS17500	COG0006	proline dipeptidase activity
BB050_RS17525	COG0668	transmembrane transport
BB050_RS17535	COG2197	response regulator
BB050_RS17550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BB050_RS17555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BB050_RS17560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BB050_RS17605	COG0438	transferase activity, transferring glycosyl groups
BB050_RS17610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BB050_RS17625	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS17630	COG1309	transcriptional regulator
BB050_RS17635	COG2985	domain, Protein
BB050_RS17655	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BB050_RS17660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BB050_RS17720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB050_RS17745	COG3264	Mechanosensitive ion channel
BB050_RS17745	COG1511	domain protein
BB050_RS17760	COG4251	negative regulation of phosphorylation
BB050_RS17770	COG2172	sigma factor antagonist activity
BB050_RS17775	COG1366	Belongs to the anti-sigma-factor antagonist family
BB050_RS17780	COG1366	Belongs to the anti-sigma-factor antagonist family
BB050_RS17790	COG1201	RNA secondary structure unwinding
BB050_RS17795	COG1793	dna ligase
BB050_RS17815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BB050_RS17820	COG0592	DNA-directed DNA polymerase activity
BB050_RS17840	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
BB050_RS17845	COG1702	phosphate starvation-inducible protein PhoH
BB050_RS17850	COG0561	phosphatase activity
BB050_RS17855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BB050_RS17890	COG2205	protein histidine kinase activity
BB050_RS17895	COG0745	RESPONSE REGULATOR receiver
BB050_RS17900	COG1363	Peptidase, m42
BB050_RS17970	COG0297	glycogen (starch) synthase activity
BB050_RS17975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BB050_RS17980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BB050_RS17990	COG4783	chaperone-mediated protein folding
BB050_RS17995	COG2270	Major facilitator Superfamily
BB050_RS18015	COG1595	DNA-templated transcription, initiation
BB050_RS18025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BB050_RS18035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BB050_RS18040	COG2211	Major facilitator Superfamily
BB050_RS18070	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BB050_RS18120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BB050_RS18180	COG0628	permease
BB050_RS18190	COG0424	maF-like protein
BB050_RS18200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BB050_RS18210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BB050_RS18210	COG1333	cytochrome c biogenesis protein
BB050_RS18225	COG1595	DNA-templated transcription, initiation
BB050_RS18230	COG0386	Belongs to the glutathione peroxidase family
BB050_RS18235	COG1247	-acetyltransferase
BB050_RS18245	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BB050_RS18255	COG2996	Protein conserved in bacteria
BB050_RS18265	COG1575	Belongs to the MenA family. Type 1 subfamily
BB050_RS18270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BB050_RS18280	COG4948	Mandelate Racemase Muconate Lactonizing
BB050_RS18290	COG2954	triphosphatase activity
BB050_RS18295	COG0492	ferredoxin-NADP+ reductase activity
BB050_RS18300	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BB050_RS18355	COG1522	sequence-specific DNA binding
BB050_RS18360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BB050_RS18370	COG0514	ATP-dependent DNA helicase (RecQ)
BB050_RS18390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BB050_RS18400	COG1132	(ABC) transporter
BB050_RS18465	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS18470	COG0024	Methionine aminopeptidase
BB050_RS18475	COG1045	serine acetyltransferase
BB050_RS18505	COG0640	Transcriptional regulator
BB050_RS18515	COG0488	(ABC) transporter
BB050_RS18550	COG0813	purine-nucleoside phosphorylase activity
BB050_RS18580	COG0668	transmembrane transport
BB050_RS18600	COG0513	Belongs to the DEAD box helicase family
BB050_RS18605	COG1252	NADH dehydrogenase
BB050_RS18610	COG2814	Major facilitator Superfamily
BB050_RS18630	COG2176	DNA-directed DNA polymerase activity
BB050_RS18640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BB050_RS18645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BB050_RS18650	COG0440	acetolactate synthase activity
BB050_RS18655	COG0028	Belongs to the TPP enzyme family
BB050_RS18660	COG0129	dihydroxy-acid dehydratase activity
BB050_RS18670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BB050_RS18690	COG0140	phosphoribosyl-ATP diphosphatase activity
BB050_RS18690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BB050_RS18695	COG0107	imidazoleglycerol-phosphate synthase activity
BB050_RS18700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BB050_RS18710	COG0131	Imidazoleglycerol-phosphate dehydratase
BB050_RS18715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BB050_RS18720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BB050_RS18725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BB050_RS18730	COG5002	protein histidine kinase activity
BB050_RS18735	COG0745	RESPONSE REGULATOR receiver
BB050_RS18740	COG1368	sulfuric ester hydrolase activity
BB050_RS18755	COG2855	membrane
BB050_RS18760	COG0583	DNA-binding transcription factor activity
BB050_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS18800	COG4771	TonB-dependent receptor
BB050_RS18825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BB050_RS18835	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB050_RS18840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BB050_RS18845	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB050_RS18850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BB050_RS18850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BB050_RS18855	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BB050_RS18860	COG1078	dGTPase activity
BB050_RS18865	COG2204	response regulator
BB050_RS18870	COG0802	atpase or kinase
BB050_RS18875	COG0686	Belongs to the AlaDH PNT family
BB050_RS18885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BB050_RS18890	COG1193	negative regulation of DNA recombination
BB050_RS18895	COG3011	Protein conserved in bacteria
BB050_RS18900	COG0488	(ABC) transporter
BB050_RS18930	COG0009	L-threonylcarbamoyladenylate synthase
BB050_RS18955	COG0308	aminopeptidase N
BB050_RS18995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BB050_RS19010	COG0840	transmembrane signaling receptor activity
BB050_RS19030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BB050_RS19035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BB050_RS19045	COG3781	membrane
BB050_RS19050	COG1917	Cupin 2, conserved barrel domain protein
BB050_RS19050	COG4977	sequence-specific DNA binding
BB050_RS19060	COG1012	belongs to the aldehyde dehydrogenase family
BB050_RS19085	COG4585	Histidine kinase
BB050_RS19095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BB050_RS19110	COG0464	growth
BB050_RS19140	COG1629	transport
BB050_RS19140	COG4206	TonB-dependent receptor
BB050_RS19145	COG0702	epimerase
BB050_RS19150	COG1131	(ABC) transporter
BB050_RS19160	COG0612	Peptidase, M16
BB050_RS19200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS19225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BB050_RS19255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BB050_RS19275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BB050_RS19295	COG3546	catalase activity
BB050_RS19305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BB050_RS19320	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS19330	COG1247	-acetyltransferase
BB050_RS19345	COG0798	PFAM Bile acid sodium symporter
BB050_RS19355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BB050_RS19375	COG2814	Major facilitator Superfamily
BB050_RS19380	COG2814	Major facilitator Superfamily
BB050_RS19395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BB050_RS19400	COG3537	Alpha-1,2-mannosidase
BB050_RS19410	COG1649	PFAM Uncharacterised BCR, COG1649
BB050_RS19420	COG0702	epimerase
BB050_RS19425	COG4771	TonB-dependent receptor
BB050_RS19450	COG1649	PFAM Uncharacterised BCR, COG1649
BB050_RS19455	COG1940	carbohydrate kinase activity
BB050_RS19465	COG1733	regulation of RNA biosynthetic process
BB050_RS19480	COG1595	DNA-templated transcription, initiation
BB050_RS19520	COG1733	regulation of RNA biosynthetic process
BB050_RS19540	COG3708	Transcriptional regulator
BB050_RS19540	COG2207	Transcriptional regulator
BB050_RS19555	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS19570	COG4221	oxidoreductase activity
BB050_RS19615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BB050_RS19625	COG1546	Belongs to the CinA family
BB050_RS19625	COG1058	Belongs to the CinA family
BB050_RS19630	COG3685	Protein conserved in bacteria
BB050_RS19755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BB050_RS19820	COG0656	L-ascorbic acid biosynthetic process
BB050_RS19830	COG0475	glutathione-regulated potassium exporter activity
BB050_RS19830	COG0589	response to stress
BB050_RS19840	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BB050_RS19850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BB050_RS19865	COG0252	asparaginase activity
BB050_RS19885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BB050_RS19900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BB050_RS19915	COG3604	Transcriptional regulator
BB050_RS19950	COG4771	TonB-dependent receptor
BB050_RS19995	COG1858	cytochrome C peroxidase
BB050_RS20035	COG1335	isochorismatase
BB050_RS20050	COG0783	Belongs to the Dps family
BB050_RS20075	COG0346	lactoylglutathione lyase activity
BB050_RS20090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BB050_RS20115	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS20140	COG3275	phosphorelay sensor kinase activity
BB050_RS20150	COG1764	response to oxidative stress
BB050_RS20170	COG0596	Alpha beta hydrolase
BB050_RS20185	COG1764	response to oxidative stress
BB050_RS20195	COG0583	DNA-binding transcription factor activity
BB050_RS20205	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BB050_RS20240	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS20245	COG1733	regulation of RNA biosynthetic process
BB050_RS20255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BB050_RS20260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BB050_RS20265	COG0363	glucosamine-6-phosphate deaminase activity
BB050_RS20310	COG2076	Multidrug Resistance protein
BB050_RS20315	COG2153	protein acetylation
BB050_RS20320	COG0583	DNA-binding transcription factor activity
BB050_RS20335	COG4191	Histidine kinase
BB050_RS20345	COG1136	(ABC) transporter
BB050_RS20345	COG0577	efflux transmembrane transporter activity
BB050_RS20355	COG3059	membrane
BB050_RS20360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BB050_RS20360	COG2207	Transcriptional regulator
BB050_RS20365	COG1215	transferase activity, transferring glycosyl groups
BB050_RS20380	COG0745	RESPONSE REGULATOR receiver
BB050_RS20385	COG0784	Response regulator, receiver
BB050_RS20385	COG2205	protein histidine kinase activity
BB050_RS20390	COG0702	epimerase
BB050_RS20450	COG2885	chlorophyll binding
BB050_RS20455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BB050_RS20475	COG3250	beta-galactosidase activity
BB050_RS20495	COG4771	TonB-dependent receptor
BB050_RS20500	COG0745	RESPONSE REGULATOR receiver
BB050_RS20500	COG3292	Two component regulator propeller
BB050_RS20500	COG2205	protein histidine kinase activity
BB050_RS20510	COG2972	Histidine kinase
BB050_RS20520	COG4206	TonB-dependent receptor
BB050_RS20540	COG1247	-acetyltransferase
BB050_RS20550	COG0657	acetylesterase activity
BB050_RS20560	COG0730	response to heat
BB050_RS20580	COG0183	Belongs to the thiolase family
BB050_RS20590	COG1053	succinate dehydrogenase
BB050_RS20595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BB050_RS20600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BB050_RS20620	COG1629	transport
BB050_RS20635	COG1858	cytochrome C peroxidase
BB050_RS20640	COG3119	arylsulfatase activity
BB050_RS20655	COG2217	Heavy metal translocating P-type atpase
BB050_RS20695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BB050_RS20705	COG2205	protein histidine kinase activity
BB050_RS20705	COG0784	Response regulator, receiver
BB050_RS20710	COG4251	negative regulation of phosphorylation
BB050_RS20715	COG1028	Short-chain dehydrogenase reductase Sdr
BB050_RS20720	COG4095	Psort location CytoplasmicMembrane, score
BB050_RS20735	COG4251	negative regulation of phosphorylation
BB050_RS20740	COG0784	Response regulator, receiver
BB050_RS20750	COG1801	Protein of unknown function DUF72
BB050_RS20760	COG3685	Protein conserved in bacteria
BB050_RS20800	COG1064	alcohol dehydrogenase
BB050_RS20835	COG0640	Transcriptional regulator
BB050_RS20840	COG1902	pentaerythritol trinitrate reductase activity
BB050_RS20845	COG2755	lipolytic protein G-D-S-L family
BB050_RS20845	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BB050_RS20855	COG1472	Belongs to the glycosyl hydrolase 3 family
BB050_RS20880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BB050_RS20885	COG3781	membrane
BB050_RS20895	COG5002	protein histidine kinase activity
BB050_RS20900	COG0745	RESPONSE REGULATOR receiver
BB050_RS20910	COG1027	Aspartate ammonia-lyase
BB050_RS20935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BB050_RS20945	COG2957	Belongs to the agmatine deiminase family
BB050_RS20970	COG2354	Protein conserved in bacteria
BB050_RS20975	COG0542	response to heat
BB050_RS21000	COG0165	Argininosuccinate lyase
BB050_RS21010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BB050_RS21015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BB050_RS21025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BB050_RS21035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BB050_RS21040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BB050_RS21045	COG0137	argininosuccinate synthase activity
BB050_RS21075	COG4628	conserved protein (DUF2132)
BB050_RS21085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BB050_RS21100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BB050_RS21110	COG1250	3-hydroxyacyl-CoA dehydrogenase
BB050_RS21130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BB050_RS21135	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BB050_RS21150	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BB050_RS21155	COG1690	Belongs to the RtcB family
BB050_RS21170	COG0237	dephospho-CoA kinase activity
BB050_RS21180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BB050_RS21190	COG0497	DNA recombination
BB050_RS21215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BB050_RS21225	COG0737	Belongs to the 5'-nucleotidase family
BB050_RS21230	COG0737	Belongs to the 5'-nucleotidase family
BB050_RS21240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BB050_RS21245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BB050_RS21245	COG2885	chlorophyll binding
BB050_RS21270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BB050_RS21275	COG0360	Binds together with S18 to 16S ribosomal RNA
BB050_RS21280	COG3279	Response regulator of the LytR AlgR family
BB050_RS21285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BB050_RS21310	COG4335	DNA alkylation repair
BB050_RS21315	COG1741	Belongs to the pirin family
BB050_RS21335	COG2329	Antibiotic biosynthesis monooxygenase
BB050_RS21340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BB050_RS21355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BB050_RS21370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BB050_RS21375	COG0149	triose-phosphate isomerase activity
BB050_RS21390	COG2264	protein methyltransferase activity
BB050_RS21425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BB050_RS21435	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
BB050_RS21500	COG0702	epimerase
BB050_RS21505	COG4771	TonB-dependent receptor
BB050_RS21520	COG0280	phosphate acetyltransferase
BB050_RS21520	COG0857	belongs to the CobB CobQ family