locus-tag	class	description
IA04_RS00015	COG0126	phosphoglycerate kinase activity
IA04_RS00020	COG0791	NLP P60 protein
IA04_RS00020	COG1388	LysM domain
IA04_RS00025	COG2153	protein acetylation
IA04_RS00040	COG1774	PSP1 C-terminal conserved region
IA04_RS00050	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IA04_RS00055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IA04_RS00060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IA04_RS00080	COG0700	Nucleoside recognition
IA04_RS00100	COG0113	porphobilinogen synthase activity
IA04_RS00110	COG0408	coproporphyrinogen oxidase activity
IA04_RS00130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IA04_RS00140	COG0181	hydroxymethylbilane synthase activity
IA04_RS00145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IA04_RS00155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IA04_RS00165	COG5000	phosphorelay sensor kinase activity
IA04_RS00170	COG1024	Enoyl-CoA hydratase
IA04_RS00175	COG1418	mRNA catabolic process
IA04_RS00200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IA04_RS00200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IA04_RS00215	COG1619	proteins homologs of microcin C7 resistance protein MccF
IA04_RS00220	COG0792	nuclease activity
IA04_RS00225	COG0667	Aldo Keto reductase
IA04_RS00230	COG1360	Flagellar Motor Protein
IA04_RS00235	COG0708	Exodeoxyribonuclease III
IA04_RS00245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IA04_RS00260	COG2239	Acts as a magnesium transporter
IA04_RS00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IA04_RS00285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IA04_RS00305	COG1914	H( )-stimulated, divalent metal cation uptake system
IA04_RS00340	COG0629	single-stranded DNA binding
IA04_RS00355	COG3590	peptidase
IA04_RS00365	COG1999	signal sequence binding
IA04_RS00385	COG1053	succinate dehydrogenase
IA04_RS00395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IA04_RS00410	COG4771	TonB-dependent receptor
IA04_RS00415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IA04_RS00435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IA04_RS00450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IA04_RS00455	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IA04_RS00460	COG0297	glycogen (starch) synthase activity
IA04_RS00470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IA04_RS00485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IA04_RS00500	COG0156	8-amino-7-oxononanoate synthase activity
IA04_RS00525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IA04_RS00580	COG0714	Associated with various cellular activities
IA04_RS00600	COG2824	Alkylphosphonate utilization operon protein PhnA
IA04_RS00605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IA04_RS00610	COG1979	alcohol dehydrogenase
IA04_RS00615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IA04_RS00625	COG0166	Belongs to the GPI family
IA04_RS00630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IA04_RS00635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IA04_RS00665	COG0006	proline dipeptidase activity
IA04_RS00685	COG0156	8-amino-7-oxononanoate synthase activity
IA04_RS00695	COG1074	ATP-dependent DNA helicase activity
IA04_RS00705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IA04_RS00720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IA04_RS00725	COG0463	Glycosyl transferase, family 2
IA04_RS00780	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IA04_RS00790	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IA04_RS00800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA04_RS00805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IA04_RS00815	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IA04_RS00820	COG2954	triphosphatase activity
IA04_RS00835	COG0328	RNA-DNA hybrid ribonuclease activity
IA04_RS00840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IA04_RS00845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IA04_RS00855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IA04_RS00860	COG0571	ribonuclease III activity
IA04_RS00870	COG0469	pyruvate kinase activity
IA04_RS00890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IA04_RS00895	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IA04_RS00945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IA04_RS00950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IA04_RS00960	COG0322	excinuclease ABC activity
IA04_RS00965	COG1752	Esterase of the alpha-beta hydrolase superfamily
IA04_RS00970	COG0531	amino acid
IA04_RS00975	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IA04_RS00980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IA04_RS00990	COG3483	tryptophan 2,3-dioxygenase activity
IA04_RS01000	COG0193	aminoacyl-tRNA hydrolase activity
IA04_RS01005	COG4935	Belongs to the peptidase S8 family
IA04_RS01005	COG1404	Belongs to the peptidase S8 family
IA04_RS01010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IA04_RS01015	COG0196	riboflavin kinase activity
IA04_RS01020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IA04_RS01035	COG0346	lactoylglutathione lyase activity
IA04_RS01040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IA04_RS01050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IA04_RS01070	COG3645	SOS response
IA04_RS01080	COG1490	D-aminoacyl-tRNA deacylase activity
IA04_RS01085	COG1162	GTPase activity
IA04_RS01090	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IA04_RS01095	COG0436	Aminotransferase
IA04_RS01145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IA04_RS01150	COG1381	Involved in DNA repair and RecF pathway recombination
IA04_RS01160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IA04_RS01180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IA04_RS01185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IA04_RS01190	COG1278	Cold shock
IA04_RS01195	COG0590	tRNA wobble adenosine to inosine editing
IA04_RS01205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IA04_RS01220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IA04_RS01260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IA04_RS01260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IA04_RS01305	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IA04_RS01310	COG0501	Belongs to the peptidase M48B family
IA04_RS01320	COG0527	aspartate kinase activity
IA04_RS01350	COG2081	HI0933 family
IA04_RS01355	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IA04_RS01380	COG1187	pseudouridine synthase activity
IA04_RS01420	COG2885	chlorophyll binding
IA04_RS01425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IA04_RS01450	COG2226	methyltransferase
IA04_RS01455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IA04_RS01480	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IA04_RS01490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IA04_RS01495	COG2086	electron transfer activity
IA04_RS01500	COG0508	dehydrogenase complex catalyzes the overall conversion of
IA04_RS01500	COG0022	dehydrogenase e1 component
IA04_RS01510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IA04_RS01540	COG0228	four-way junction DNA binding
IA04_RS01545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IA04_RS01550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IA04_RS01555	COG1960	acyl-CoA dehydrogenase activity
IA04_RS01560	COG0194	GDP metabolic process
IA04_RS01590	COG0626	cystathionine gamma-synthase activity
IA04_RS01610	COG0745	RESPONSE REGULATOR receiver
IA04_RS01615	COG5002	protein histidine kinase activity
IA04_RS01635	COG0581	inorganic phosphate transmembrane transporter activity
IA04_RS01640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IA04_RS01645	COG0704	Plays a role in the regulation of phosphate uptake
IA04_RS01650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IA04_RS01660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IA04_RS01685	COG0437	4 iron, 4 sulfur cluster binding
IA04_RS01710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IA04_RS01715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IA04_RS01730	COG4717	serine-type aminopeptidase activity
IA04_RS01765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IA04_RS01770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IA04_RS01795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IA04_RS01805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IA04_RS01810	COG1428	Deoxynucleoside kinase
IA04_RS01815	COG0616	signal peptide processing
IA04_RS01830	COG0860	N-Acetylmuramoyl-L-alanine amidase
IA04_RS01840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IA04_RS01840	COG1519	Transferase
IA04_RS01850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IA04_RS01860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IA04_RS01870	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IA04_RS01875	COG0436	Aminotransferase
IA04_RS01880	COG3239	Fatty acid desaturase
IA04_RS01885	COG0357	Ribosomal RNA small subunit methyltransferase G
IA04_RS01890	COG1012	belongs to the aldehyde dehydrogenase family
IA04_RS01900	COG2967	ApaG domain
IA04_RS01930	COG2274	protein secretion by the type I secretion system
IA04_RS01940	COG0427	acetyl-CoA hydrolase
IA04_RS01950	COG2217	Heavy metal translocating P-type atpase
IA04_RS01970	COG0351	phosphomethylpyrimidine kinase
IA04_RS01975	COG0352	thiamine-phosphate diphosphorylase activity
IA04_RS01980	COG2022	thiamine diphosphate biosynthetic process
IA04_RS01990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IA04_RS01995	COG0528	UMP kinase activity
IA04_RS02000	COG0233	cytoplasmic translational termination
IA04_RS02025	COG0475	glutathione-regulated potassium exporter activity
IA04_RS02040	COG2211	Major facilitator Superfamily
IA04_RS02045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IA04_RS02050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IA04_RS02055	COG0440	acetolactate synthase activity
IA04_RS02060	COG0028	Belongs to the TPP enzyme family
IA04_RS02065	COG0129	dihydroxy-acid dehydratase activity
IA04_RS02085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IA04_RS02090	COG0052	Belongs to the universal ribosomal protein uS2 family
IA04_RS02095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IA04_RS02100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IA04_RS02105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IA04_RS02105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IA04_RS02120	COG2095	MarC family integral membrane protein
IA04_RS02135	COG0793	Belongs to the peptidase S41A family
IA04_RS02155	COG0589	response to stress
IA04_RS02160	COG0779	Required for maturation of 30S ribosomal subunits
IA04_RS02165	COG0195	Participates in both transcription termination and antitermination
IA04_RS02165	COG2251	uridine kinase activity
IA04_RS02170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IA04_RS02175	COG1217	gtp-binding protein TYPA
IA04_RS02180	COG2996	Protein conserved in bacteria
IA04_RS02190	COG1575	Belongs to the MenA family. Type 1 subfamily
IA04_RS02300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IA04_RS02325	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IA04_RS02345	COG1309	transcriptional regulator
IA04_RS02355	COG0159	tryptophan synthase activity
IA04_RS02360	COG0133	tryptophan synthase activity
IA04_RS02365	COG0135	phosphoribosylanthranilate isomerase activity
IA04_RS02370	COG0134	indole-3-glycerol-phosphate synthase activity
IA04_RS02375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IA04_RS02380	COG0512	Glutamine amidotransferase of anthranilate synthase
IA04_RS02380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IA04_RS02385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IA04_RS02395	COG0778	Nitroreductase
IA04_RS02405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IA04_RS02415	COG2884	Cell division ATP-binding protein ftsE
IA04_RS02430	COG4771	TonB-dependent receptor
IA04_RS02440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IA04_RS02450	COG0367	asparagine synthase
IA04_RS02455	COG0187	DNA topoisomerase II activity
IA04_RS02465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IA04_RS02470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IA04_RS02480	COG1132	(ABC) transporter
IA04_RS02490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IA04_RS02500	COG1862	Preprotein translocase
IA04_RS02505	COG0284	orotidine-5'-phosphate decarboxylase activity
IA04_RS02510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IA04_RS02525	COG0285	dihydrofolate synthase activity
IA04_RS02535	COG0848	biopolymer transport protein
IA04_RS02565	COG4771	TonB-dependent receptor
IA04_RS02570	COG2304	oxidoreductase activity
IA04_RS02615	COG0488	(ABC) transporter
IA04_RS02635	COG0514	ATP-dependent DNA helicase (RecQ)
IA04_RS02655	COG2326	polyphosphate kinase activity
IA04_RS02665	COG1858	cytochrome C peroxidase
IA04_RS02670	COG0534	Mate efflux family protein
IA04_RS02690	COG2223	nitrite transmembrane transporter activity
IA04_RS02695	COG0277	FAD linked oxidase domain protein
IA04_RS02720	COG1858	cytochrome C peroxidase
IA04_RS02730	COG0653	protein targeting
IA04_RS02745	COG1136	(ABC) transporter
IA04_RS02765	COG0488	(ABC) transporter
IA04_RS02780	COG0508	dehydrogenase complex catalyzes the overall conversion of
IA04_RS02810	COG0302	gtp cyclohydrolase
IA04_RS02815	COG0215	cysteine-tRNA ligase activity
IA04_RS02820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IA04_RS02825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IA04_RS02830	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IA04_RS02830	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IA04_RS02835	COG0799	negative regulation of ribosome biogenesis
IA04_RS02840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IA04_RS02850	COG4589	Belongs to the CDS family
IA04_RS02855	COG0688	phosphatidylethanolamine metabolic process
IA04_RS02875	COG0343	queuine tRNA-ribosyltransferase activity
IA04_RS02890	COG0825	malonyl-CoA metabolic process
IA04_RS02895	COG0305	Participates in initiation and elongation during chromosome replication
IA04_RS02900	COG0492	ferredoxin-NADP+ reductase activity
IA04_RS02915	COG3781	membrane
IA04_RS02920	COG3158	transport of potassium into the cell
IA04_RS02945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IA04_RS02950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IA04_RS02960	COG1136	(ABC) transporter
IA04_RS02965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IA04_RS02970	COG0302	gtp cyclohydrolase
IA04_RS02995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IA04_RS03000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IA04_RS03010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IA04_RS03025	COG4771	TonB-dependent receptor
IA04_RS03050	COG2234	aminopeptidase activity
IA04_RS03055	COG0564	pseudouridine synthase activity
IA04_RS03065	COG1181	Belongs to the D-alanine--D-alanine ligase family
IA04_RS03070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IA04_RS03080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IA04_RS03095	COG1169	isochorismate synthase
IA04_RS03100	COG2050	protein possibly involved in aromatic compounds catabolism
IA04_RS03110	COG0513	Belongs to the DEAD box helicase family
IA04_RS03120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IA04_RS03140	COG2204	response regulator
IA04_RS03145	COG1668	transmembrane transport
IA04_RS03150	COG4152	abc transporter atp-binding protein
IA04_RS03155	COG0484	heat shock protein binding
IA04_RS03160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IA04_RS03165	COG1090	epimerase
IA04_RS03210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IA04_RS03220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IA04_RS03225	COG3958	Transketolase
IA04_RS03235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IA04_RS03295	COG2356	endonuclease I
IA04_RS03300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IA04_RS03300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IA04_RS03330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IA04_RS03345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IA04_RS03355	COG1104	cysteine desulfurase activity
IA04_RS03390	COG2197	response regulator
IA04_RS03405	COG3022	response to hydroperoxide
IA04_RS03410	COG0022	dehydrogenase e1 component
IA04_RS03420	COG2356	endonuclease I
IA04_RS03425	COG0861	Integral membrane protein TerC family
IA04_RS03440	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IA04_RS03460	COG0116	Belongs to the methyltransferase superfamily
IA04_RS03460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IA04_RS03485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IA04_RS03510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IA04_RS03535	COG2321	neutral zinc metallopeptidase
IA04_RS03540	COG2323	membrane
IA04_RS03545	COG0189	ligase activity
IA04_RS03545	COG4067	protein conserved in archaea
IA04_RS03550	COG0542	response to heat
IA04_RS03565	COG0251	oxidation-reduction process
IA04_RS03575	COG0860	N-Acetylmuramoyl-L-alanine amidase
IA04_RS03585	COG0247	lactate metabolic process
IA04_RS03585	COG2181	nitrate reductase activity
IA04_RS03595	COG0247	lactate metabolic process
IA04_RS03595	COG2181	nitrate reductase activity
IA04_RS03605	COG1472	Belongs to the glycosyl hydrolase 3 family
IA04_RS03625	COG0438	transferase activity, transferring glycosyl groups
IA04_RS03630	COG0583	DNA-binding transcription factor activity
IA04_RS03640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IA04_RS03645	COG1301	dicarboxylic acid transport
IA04_RS03655	COG3011	Protein conserved in bacteria
IA04_RS03660	COG0791	NLP P60 protein
IA04_RS03665	COG0183	Belongs to the thiolase family
IA04_RS03685	COG1132	(ABC) transporter
IA04_RS03690	COG0217	transcriptional regulatory protein
IA04_RS03695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IA04_RS03700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IA04_RS03705	COG2986	histidine ammonia-lyase
IA04_RS03735	COG1522	sequence-specific DNA binding
IA04_RS03745	COG1611	Belongs to the LOG family
IA04_RS03760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IA04_RS03780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IA04_RS03830	COG0443	Heat shock 70 kDa protein
IA04_RS03855	COG0009	L-threonylcarbamoyladenylate synthase
IA04_RS03860	COG1770	oligopeptidase
IA04_RS03875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IA04_RS03885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IA04_RS03890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IA04_RS03890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IA04_RS03920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IA04_RS03925	COG1760	l-serine dehydratase
IA04_RS03935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IA04_RS03940	COG0793	Belongs to the peptidase S41A family
IA04_RS03945	COG0564	pseudouridine synthase activity
IA04_RS03950	COG1012	belongs to the aldehyde dehydrogenase family
IA04_RS03965	COG0612	Peptidase, M16
IA04_RS03970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IA04_RS03975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IA04_RS03980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IA04_RS03985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IA04_RS04005	COG0556	nucleotide-excision repair
IA04_RS04030	COG0045	succinate-CoA ligase (ADP-forming) activity
IA04_RS04060	COG0450	alkyl hydroperoxide reductase
IA04_RS04090	COG3278	Belongs to the heme-copper respiratory oxidase family
IA04_RS04095	COG1136	(ABC) transporter
IA04_RS04125	COG0450	alkyl hydroperoxide reductase
IA04_RS04135	COG3012	SEC-C Motif Domain Protein
IA04_RS04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA04_RS04165	COG0463	Glycosyl transferase, family 2
IA04_RS04195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IA04_RS04230	COG0668	transmembrane transport
IA04_RS04235	COG1607	acyl-coa hydrolase
IA04_RS04250	COG0140	phosphoribosyl-ATP diphosphatase activity
IA04_RS04250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IA04_RS04255	COG0107	imidazoleglycerol-phosphate synthase activity
IA04_RS04260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IA04_RS04265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IA04_RS04270	COG0131	Imidazoleglycerol-phosphate dehydratase
IA04_RS04270	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IA04_RS04275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IA04_RS04280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IA04_RS04285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IA04_RS04295	COG1368	sulfuric ester hydrolase activity
IA04_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
IA04_RS04310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IA04_RS04330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IA04_RS04340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IA04_RS04350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA04_RS04355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IA04_RS04360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA04_RS04365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IA04_RS04365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IA04_RS04370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA04_RS04375	COG1078	dGTPase activity
IA04_RS04385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IA04_RS04410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IA04_RS04410	COG0116	Belongs to the methyltransferase superfamily
IA04_RS04440	COG1309	transcriptional regulator
IA04_RS04455	COG4716	Myosin-crossreactive antigen
IA04_RS04460	COG1250	3-hydroxyacyl-CoA dehydrogenase
IA04_RS04465	COG4716	Myosin-crossreactive antigen
IA04_RS04475	COG0306	phosphate transporter
IA04_RS04490	COG0793	Belongs to the peptidase S41A family
IA04_RS04505	COG1881	PFAM PEBP family protein
IA04_RS04525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IA04_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
IA04_RS04545	COG0415	Belongs to the DNA photolyase family
IA04_RS04550	COG0784	Response regulator, receiver
IA04_RS04560	COG4251	negative regulation of phosphorylation
IA04_RS04570	COG4251	negative regulation of phosphorylation
IA04_RS04580	COG3279	Response regulator of the LytR AlgR family
IA04_RS04605	COG0069	glutamate synthase activity
IA04_RS04610	COG0179	Fumarylacetoacetate (FAA) hydrolase
IA04_RS04615	COG0826	peptidase U32
IA04_RS04620	COG0022	dehydrogenase e1 component
IA04_RS04640	COG0813	purine-nucleoside phosphorylase activity
IA04_RS04645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IA04_RS04670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IA04_RS04675	COG1193	negative regulation of DNA recombination
IA04_RS04690	COG0488	(ABC) transporter
IA04_RS04720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IA04_RS04725	COG0300	oxidoreductase activity
IA04_RS04770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IA04_RS04780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IA04_RS04790	COG1435	thymidine kinase activity
IA04_RS04795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IA04_RS04800	COG1970	mechanosensitive ion channel activity
IA04_RS04805	COG2204	response regulator
IA04_RS04810	COG0802	atpase or kinase
IA04_RS04815	COG0686	Belongs to the AlaDH PNT family
IA04_RS04860	COG1363	Peptidase, m42
IA04_RS04865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IA04_RS04875	COG1702	phosphate starvation-inducible protein PhoH
IA04_RS04925	COG0592	DNA-directed DNA polymerase activity
IA04_RS04930	COG0513	Belongs to the DEAD box helicase family
IA04_RS04940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IA04_RS04960	COG1234	tRNA 3'-trailer cleavage
IA04_RS04970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IA04_RS04975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IA04_RS05000	COG1595	DNA-templated transcription, initiation
IA04_RS05005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IA04_RS05015	COG1446	asparaginase
IA04_RS05020	COG4242	Belongs to the peptidase S51 family
IA04_RS05030	COG1506	peptidase
IA04_RS05030	COG0823	Involved in the tonB-independent uptake of proteins
IA04_RS05065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA04_RS05065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA04_RS05075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA04_RS05075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA04_RS05090	COG0681	Belongs to the peptidase S26 family
IA04_RS05095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IA04_RS05105	COG1475	DNA binding
IA04_RS05110	COG1192	Involved in chromosome partitioning
IA04_RS05115	COG1028	Short-chain dehydrogenase reductase Sdr
IA04_RS05120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IA04_RS05130	COG0254	rRNA binding
IA04_RS05140	COG0463	Glycosyl transferase, family 2
IA04_RS05145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IA04_RS05150	COG1132	(ABC) transporter
IA04_RS05170	COG0739	heme binding
IA04_RS05185	COG1418	mRNA catabolic process
IA04_RS05190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IA04_RS05220	COG2217	Heavy metal translocating P-type atpase
IA04_RS05235	COG3278	Belongs to the heme-copper respiratory oxidase family
IA04_RS05250	COG0348	domain, Protein
IA04_RS05270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IA04_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
IA04_RS05285	COG0714	Associated with various cellular activities
IA04_RS05290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IA04_RS05295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IA04_RS05305	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IA04_RS05315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IA04_RS05320	COG0085	RNA polymerase activity
IA04_RS05325	COG0222	ribosome binding
IA04_RS05330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IA04_RS05335	COG0081	regulation of translation
IA04_RS05340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IA04_RS05360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IA04_RS05385	COG4974	Belongs to the 'phage' integrase family
IA04_RS05390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IA04_RS05395	COG1960	acyl-CoA dehydrogenase activity
IA04_RS05410	COG0470	DNA polymerase III
IA04_RS05415	COG2176	DNA-directed DNA polymerase activity
IA04_RS05435	COG4771	TonB-dependent receptor
IA04_RS05440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IA04_RS05445	COG0321	lipoyl(octanoyl) transferase activity
IA04_RS05450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IA04_RS05460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IA04_RS05465	COG1388	LysM domain
IA04_RS05465	COG0791	NLP P60 protein
IA04_RS05470	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IA04_RS05475	COG0824	Thioesterase
IA04_RS05480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IA04_RS05490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IA04_RS05505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IA04_RS05515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IA04_RS05520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IA04_RS05530	COG0791	NLP P60 protein
IA04_RS05535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IA04_RS05550	COG1187	pseudouridine synthase activity
IA04_RS05555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IA04_RS05570	COG4680	protein conserved in bacteria
IA04_RS05580	COG0668	transmembrane transport
IA04_RS05585	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IA04_RS05605	COG0514	ATP-dependent DNA helicase (RecQ)
IA04_RS05610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IA04_RS05610	COG0517	IMP dehydrogenase activity
IA04_RS05615	COG0805	protein transport
IA04_RS05625	COG1137	ATPase activity
IA04_RS05660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IA04_RS05680	COG1045	serine acetyltransferase
IA04_RS05695	COG1216	Glycosyl transferase, family 2
IA04_RS05705	COG1045	serine acetyltransferase
IA04_RS05720	COG2089	acid synthase
IA04_RS05725	COG1083	cytidylyl-transferase
IA04_RS05745	COG1216	Glycosyl transferase, family 2
IA04_RS05745	COG1442	glycosyl transferase family 8
IA04_RS05750	COG0438	transferase activity, transferring glycosyl groups
IA04_RS05765	COG1216	Glycosyl transferase, family 2
IA04_RS05805	COG4464	protein tyrosine phosphatase activity
IA04_RS05810	COG0489	protein tyrosine kinase activity
IA04_RS05825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IA04_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
IA04_RS05850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IA04_RS05855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IA04_RS05860	COG0297	glycogen (starch) synthase activity
IA04_RS05880	COG1086	Polysaccharide biosynthesis protein
IA04_RS05905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IA04_RS05915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IA04_RS05920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IA04_RS05930	COG0489	protein tyrosine kinase activity
IA04_RS05940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IA04_RS05945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IA04_RS05955	COG2095	MarC family integral membrane protein
IA04_RS05980	COG0148	phosphopyruvate hydratase activity
IA04_RS05985	COG2312	Erythromycin esterase
IA04_RS05990	COG0505	Belongs to the CarA family
IA04_RS05995	COG0203	ribosomal protein L17
IA04_RS06000	COG0202	RNA polymerase activity
IA04_RS06005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IA04_RS06010	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IA04_RS06015	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IA04_RS06020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IA04_RS06025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IA04_RS06030	COG0201	protein transport
IA04_RS06035	COG0200	Binds to the 23S rRNA
IA04_RS06040	COG1841	ribosomal large subunit assembly
IA04_RS06045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IA04_RS06050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IA04_RS06055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IA04_RS06060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IA04_RS06065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IA04_RS06070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IA04_RS06075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IA04_RS06080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IA04_RS06085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IA04_RS06090	COG0255	Belongs to the universal ribosomal protein uL29 family
IA04_RS06095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IA04_RS06100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IA04_RS06105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IA04_RS06110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IA04_RS06115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IA04_RS06120	COG0089	rRNA binding
IA04_RS06125	COG0088	Forms part of the polypeptide exit tunnel
IA04_RS06130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IA04_RS06135	COG0051	transcription antitermination factor activity, RNA binding
IA04_RS06140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IA04_RS06145	COG0049	tRNA binding
IA04_RS06150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IA04_RS06160	COG1629	transport
IA04_RS06160	COG4206	TonB-dependent receptor
IA04_RS06170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IA04_RS06180	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IA04_RS06195	COG2003	Belongs to the UPF0758 family
IA04_RS06200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IA04_RS06210	COG3591	Belongs to the peptidase S1B family
IA04_RS06215	COG1652	LysM domain
IA04_RS06220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IA04_RS06230	COG1253	flavin adenine dinucleotide binding
IA04_RS06235	COG0563	adenylate kinase activity
IA04_RS06240	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IA04_RS06250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IA04_RS06255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IA04_RS06295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IA04_RS06295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IA04_RS06315	COG1442	glycosyl transferase family 8
IA04_RS06315	COG1216	Glycosyl transferase, family 2
IA04_RS06320	COG1215	transferase activity, transferring glycosyl groups
IA04_RS06325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IA04_RS06330	COG1127	ABC transporter
IA04_RS06350	COG1028	Short-chain dehydrogenase reductase Sdr
IA04_RS06360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IA04_RS06365	COG0295	cytidine deaminase activity
IA04_RS06385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IA04_RS06395	COG0268	Binds directly to 16S ribosomal RNA
IA04_RS06410	COG0442	prolyl-tRNA aminoacylation
IA04_RS06425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IA04_RS06450	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IA04_RS06455	COG0105	UTP biosynthetic process
IA04_RS06465	COG1696	Membrane protein involved in D-alanine export
IA04_RS06495	COG0386	Belongs to the glutathione peroxidase family
IA04_RS06500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IA04_RS06500	COG1333	cytochrome c biogenesis protein
IA04_RS06520	COG0424	maF-like protein
IA04_RS06525	COG0101	tRNA pseudouridine synthase activity
IA04_RS06530	COG1132	(ABC) transporter
IA04_RS06535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IA04_RS06550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IA04_RS06555	COG0149	triose-phosphate isomerase activity
IA04_RS06560	COG0552	protein localization to endoplasmic reticulum
IA04_RS06570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IA04_RS06575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IA04_RS06580	COG1058	Belongs to the CinA family
IA04_RS06580	COG1546	Belongs to the CinA family
IA04_RS06595	COG0179	Fumarylacetoacetate (FAA) hydrolase
IA04_RS06600	COG5002	protein histidine kinase activity
IA04_RS06600	COG2176	DNA-directed DNA polymerase activity
IA04_RS06610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IA04_RS06615	COG0500	methyltransferase
IA04_RS06620	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IA04_RS06625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IA04_RS06695	COG4206	TonB-dependent receptor
IA04_RS06710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IA04_RS06715	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
IA04_RS06730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IA04_RS06755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IA04_RS06775	COG1663	tetraacyldisaccharide 4'-kinase activity
IA04_RS06785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IA04_RS06790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IA04_RS06870	COG2202	Pas domain
IA04_RS06870	COG1366	Belongs to the anti-sigma-factor antagonist family
IA04_RS06890	COG4771	TonB-dependent receptor
IA04_RS06905	COG0018	arginyl-trna synthetase
IA04_RS06925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IA04_RS06940	COG3842	ATPase activity
IA04_RS06955	COG2885	chlorophyll binding
IA04_RS06965	COG0326	Molecular chaperone. Has ATPase activity
IA04_RS07000	COG3275	phosphorelay sensor kinase activity
IA04_RS07005	COG3279	Response regulator of the LytR AlgR family
IA04_RS07050	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IA04_RS07310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IA04_RS07340	COG0183	Belongs to the thiolase family
IA04_RS07345	COG1309	transcriptional regulator
IA04_RS07360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IA04_RS07360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IA04_RS07375	COG1674	ftsk spoiiie
IA04_RS07405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IA04_RS07420	COG1266	CAAX protease self-immunity
IA04_RS07425	COG1393	Belongs to the ArsC family
IA04_RS07430	COG4206	TonB-dependent receptor
IA04_RS07455	COG2962	Rard protein
IA04_RS07460	COG0606	chelatase, subunit chli
IA04_RS07480	COG0205	6-phosphofructokinase activity
IA04_RS07490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IA04_RS07510	COG0628	permease
IA04_RS07535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IA04_RS07540	COG0037	tRNA processing
IA04_RS07550	COG2171	N-acyltransferase activity
IA04_RS07580	COG0463	Glycosyl transferase, family 2
IA04_RS07595	COG0438	transferase activity, transferring glycosyl groups
IA04_RS07595	COG4641	Protein conserved in bacteria
IA04_RS07600	COG1215	transferase activity, transferring glycosyl groups
IA04_RS07610	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IA04_RS07615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IA04_RS07620	COG0463	Glycosyl transferase, family 2
IA04_RS07630	COG0617	tRNA 3'-terminal CCA addition
IA04_RS07630	COG0517	IMP dehydrogenase activity
IA04_RS07630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IA04_RS07635	COG1612	heme a metabolic process
IA04_RS07645	COG3279	Response regulator of the LytR AlgR family
IA04_RS07665	COG3275	phosphorelay sensor kinase activity
IA04_RS07705	COG1131	(ABC) transporter
IA04_RS07745	COG1530	ribonuclease E activity
IA04_RS07750	COG0489	protein tyrosine kinase activity
IA04_RS07755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IA04_RS07760	COG0492	ferredoxin-NADP+ reductase activity
IA04_RS07770	COG0697	spore germination
IA04_RS07790	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IA04_RS07795	COG1247	-acetyltransferase
IA04_RS07800	COG2264	protein methyltransferase activity
IA04_RS07840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IA04_RS07850	COG2205	protein histidine kinase activity
IA04_RS07860	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IA04_RS07865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IA04_RS07870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IA04_RS07885	COG2204	response regulator
IA04_RS07895	COG0436	Aminotransferase
IA04_RS07910	COG0525	valine-tRNA ligase activity
IA04_RS07920	COG0010	Belongs to the arginase family
IA04_RS07925	COG0513	Belongs to the DEAD box helicase family
IA04_RS07930	COG1704	LemA family
IA04_RS07940	COG0259	pyridoxamine-phosphate oxidase activity
IA04_RS07945	COG1234	tRNA 3'-trailer cleavage
IA04_RS07955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IA04_RS07975	COG2211	Major facilitator Superfamily
IA04_RS07980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IA04_RS07990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IA04_RS07995	COG2270	Major facilitator Superfamily
IA04_RS08010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IA04_RS08015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IA04_RS08020	COG1022	Amp-dependent synthetase and ligase
IA04_RS08025	COG0405	Gamma-glutamyltransferase
IA04_RS08030	COG1846	Transcriptional regulator
IA04_RS08035	COG1024	Enoyl-CoA hydratase
IA04_RS08035	COG1250	3-hydroxyacyl-CoA dehydrogenase
IA04_RS08045	COG0183	Belongs to the thiolase family
IA04_RS08050	COG1960	acyl-CoA dehydrogenase activity
IA04_RS08065	COG0450	alkyl hydroperoxide reductase
IA04_RS08070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IA04_RS08080	COG0531	amino acid
IA04_RS08085	COG0626	cystathionine gamma-synthase activity
IA04_RS08095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IA04_RS08100	COG2032	superoxide dismutase activity
IA04_RS08120	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IA04_RS08120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IA04_RS08145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IA04_RS08160	COG2814	Major facilitator Superfamily
IA04_RS08175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IA04_RS08180	COG0579	oxidoreductase
IA04_RS08185	COG0242	peptide deformylase activity
IA04_RS08195	COG3956	TIGRFAM MazG family protein
IA04_RS08220	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
IA04_RS08230	COG1404	Belongs to the peptidase S8 family
IA04_RS08235	COG0488	(ABC) transporter
IA04_RS08240	COG0542	response to heat
IA04_RS08255	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IA04_RS08260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IA04_RS08270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IA04_RS08280	COG0038	chloride channel
IA04_RS08285	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IA04_RS08290	COG0482	sulfurtransferase activity
IA04_RS08305	COG0598	Magnesium transport protein CorA
IA04_RS08310	COG1228	amidohydrolase
IA04_RS08335	COG4774	siderophore transport
IA04_RS08355	COG1482	cell wall glycoprotein biosynthetic process
IA04_RS08360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IA04_RS08370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IA04_RS08375	COG0539	negative regulation of cytoplasmic translation
IA04_RS08385	COG0540	Belongs to the ATCase OTCase family
IA04_RS08390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IA04_RS08400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IA04_RS08425	COG0156	8-amino-7-oxononanoate synthase activity
IA04_RS08435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IA04_RS08440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IA04_RS08470	COG0492	ferredoxin-NADP+ reductase activity
IA04_RS08470	COG3118	belongs to the thioredoxin family
IA04_RS08485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IA04_RS08485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IA04_RS08505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IA04_RS08510	COG0516	GMP reductase activity
IA04_RS08510	COG0517	IMP dehydrogenase activity
IA04_RS08530	COG0167	dihydroorotate dehydrogenase activity
IA04_RS08550	COG3118	belongs to the thioredoxin family
IA04_RS08585	COG0737	Belongs to the 5'-nucleotidase family
IA04_RS08600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IA04_RS08625	COG0497	DNA recombination
IA04_RS08630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IA04_RS08650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IA04_RS08660	COG0359	binds to the 23S rRNA
IA04_RS08665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IA04_RS08670	COG0360	Binds together with S18 to 16S ribosomal RNA
IA04_RS08675	COG3279	Response regulator of the LytR AlgR family
IA04_RS08680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IA04_RS08690	COG1295	ribonuclease BN
IA04_RS08700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IA04_RS08700	COG1017	nitric oxide dioxygenase activity
IA04_RS08715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IA04_RS08720	COG0463	Glycosyl transferase, family 2
IA04_RS08725	COG1216	Glycosyl transferase, family 2
IA04_RS08725	COG0463	Glycosyl transferase, family 2
IA04_RS08745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IA04_RS08750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IA04_RS08755	COG2860	membrane
IA04_RS08775	COG0538	isocitrate dehydrogenase activity
IA04_RS08780	COG0335	large ribosomal subunit rRNA binding
IA04_RS08785	COG0336	Belongs to the RNA methyltransferase TrmD family
IA04_RS08825	COG0339	signal peptide processing
IA04_RS08830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IA04_RS08835	COG4628	conserved protein (DUF2132)
IA04_RS08840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IA04_RS08860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IA04_RS08865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IA04_RS08875	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IA04_RS08880	COG0519	Catalyzes the synthesis of GMP from XMP
IA04_RS08880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IA04_RS08900	COG3530	Putative quorum-sensing-regulated virulence factor
IA04_RS08905	COG0504	CTP synthase activity
IA04_RS08910	COG0706	membrane insertase activity
IA04_RS08920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IA04_RS08940	COG1696	Membrane protein involved in D-alanine export
IA04_RS08950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IA04_RS08955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IA04_RS08960	COG0673	inositol 2-dehydrogenase activity
IA04_RS08965	COG1250	3-hydroxyacyl-CoA dehydrogenase
IA04_RS08990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IA04_RS09000	COG2195	Cleaves the N-terminal amino acid of tripeptides
IA04_RS09010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IA04_RS09040	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IA04_RS09045	COG1960	acyl-CoA dehydrogenase activity
IA04_RS09050	COG2195	Cleaves the N-terminal amino acid of tripeptides
IA04_RS09105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA04_RS09105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IA04_RS09105	COG1703	isobutyryl-CoA mutase activity
IA04_RS09110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IA04_RS09115	COG4942	peptidase
IA04_RS09125	COG1704	LemA family
IA04_RS09135	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IA04_RS09160	COG1132	(ABC) transporter
IA04_RS09180	COG3186	Phenylalanine-4-hydroxylase
IA04_RS09195	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IA04_RS09215	COG1160	GTP binding
IA04_RS09220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IA04_RS09245	COG0488	(ABC) transporter
IA04_RS09295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IA04_RS09325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IA04_RS09330	COG2204	response regulator
IA04_RS09350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IA04_RS09355	COG0459	protein refolding
IA04_RS09365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IA04_RS09380	COG1607	acyl-coa hydrolase
IA04_RS09395	COG1187	pseudouridine synthase activity
IA04_RS09400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IA04_RS09405	COG1120	ATPase activity
IA04_RS09410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IA04_RS09415	COG0367	asparagine synthase
IA04_RS09430	COG3118	belongs to the thioredoxin family
IA04_RS09435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IA04_RS09445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IA04_RS09465	COG1678	Uncharacterized ACR, COG1678
IA04_RS09475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IA04_RS09480	COG0514	ATP-dependent DNA helicase (RecQ)
IA04_RS09500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IA04_RS09520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IA04_RS09530	COG4974	Belongs to the 'phage' integrase family
IA04_RS09535	COG0124	histidyl-tRNA synthetase
IA04_RS09545	COG2890	protein-(glutamine-N5) methyltransferase activity
IA04_RS09555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IA04_RS09555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IA04_RS09565	COG1739	Uncharacterized protein family UPF0029
IA04_RS09575	COG0288	reversible hydration of carbon dioxide
IA04_RS09615	COG1956	GAF domain-containing protein
IA04_RS09635	COG0415	Belongs to the DNA photolyase family
IA04_RS09640	COG3046	protein related to deoxyribodipyrimidine photolyase
IA04_RS09645	COG0415	Belongs to the DNA photolyase family
IA04_RS09650	COG0702	epimerase
IA04_RS09655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IA04_RS09660	COG1185	polyribonucleotide nucleotidyltransferase activity
IA04_RS09670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IA04_RS09675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IA04_RS09690	COG1610	YqeY-like protein
IA04_RS09695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IA04_RS09710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IA04_RS09715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IA04_RS09720	COG0772	Belongs to the SEDS family
IA04_RS09725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IA04_RS09730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IA04_RS09735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IA04_RS09740	COG0768	penicillin binding
IA04_RS09750	COG0275	rRNA processing
IA04_RS09755	COG2001	Belongs to the MraZ family
IA04_RS09765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IA04_RS09780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IA04_RS09790	COG0358	DNA primase activity
IA04_RS09830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IA04_RS09840	COG0671	phosphoesterase, PA-phosphatase related
IA04_RS09845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IA04_RS09850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IA04_RS09860	COG0544	peptidyl-prolyl cis-trans isomerase activity
IA04_RS09865	COG1950	PFAM Membrane protein of
IA04_RS09880	COG1131	(ABC) transporter
IA04_RS09885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IA04_RS09895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IA04_RS09925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IA04_RS09930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IA04_RS09945	COG1331	Highly conserved protein containing a thioredoxin domain
IA04_RS09955	COG1214	PFAM Peptidase M22, glycoprotease
IA04_RS09960	COG0109	protoheme IX farnesyltransferase activity
IA04_RS09985	COG1999	signal sequence binding
IA04_RS09990	COG2322	membrane
IA04_RS10010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IA04_RS10020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IA04_RS10030	COG0509	glycine decarboxylation via glycine cleavage system
IA04_RS10040	COG0632	four-way junction helicase activity
IA04_RS10045	COG0281	malic enzyme
IA04_RS10045	COG0280	phosphate acetyltransferase
IA04_RS10050	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IA04_RS10055	COG2255	four-way junction helicase activity
IA04_RS10060	COG0531	amino acid
IA04_RS10080	COG3340	Belongs to the peptidase S51 family
IA04_RS10090	COG0456	acetyltransferase
IA04_RS10095	COG2989	Protein conserved in bacteria
IA04_RS10105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IA04_RS10110	COG4974	Belongs to the 'phage' integrase family
IA04_RS10210	COG1196	nuclear chromosome segregation
IA04_RS10260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IA04_RS10285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IA04_RS10340	COG3876	Protein conserved in bacteria
IA04_RS10360	COG0602	queuosine metabolic process
IA04_RS10420	COG0433	COG0433 Predicted ATPase
IA04_RS10425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IA04_RS10435	COG0010	Belongs to the arginase family
IA04_RS10440	COG3844	kynureninase activity
IA04_RS10445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IA04_RS10450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IA04_RS10455	COG1007	ATP synthesis coupled electron transport
IA04_RS10460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA04_RS10465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IA04_RS10470	COG0713	ATP synthesis coupled electron transport
IA04_RS10475	COG0839	Belongs to the complex I subunit 6 family
IA04_RS10480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA04_RS10485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IA04_RS10490	COG1034	ATP synthesis coupled electron transport
IA04_RS10505	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IA04_RS10510	COG0649	NAD binding
IA04_RS10515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA04_RS10520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA04_RS10525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IA04_RS10535	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IA04_RS10570	COG0481	GTPase activity
IA04_RS10585	COG3328	transposase activity
IA04_RS10590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IA04_RS10605	COG0720	synthase
IA04_RS10610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IA04_RS10615	COG0017	Asparaginyl-tRNA synthetase
IA04_RS10630	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IA04_RS10660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IA04_RS10690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IA04_RS10700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IA04_RS10725	COG1131	(ABC) transporter
IA04_RS10755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IA04_RS10760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IA04_RS10770	COG1233	COG1233 Phytoene dehydrogenase and related
IA04_RS10780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IA04_RS10785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IA04_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
IA04_RS10810	COG0084	hydrolase, TatD family'
IA04_RS10820	COG0252	asparaginase activity
IA04_RS10870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IA04_RS10880	COG4968	Prepilin-type N-terminal cleavage methylation domain
IA04_RS10915	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
IA04_RS11010	COG1012	belongs to the aldehyde dehydrogenase family
IA04_RS11015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IA04_RS11025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IA04_RS11030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IA04_RS11035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA04_RS11045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IA04_RS11050	COG0793	Belongs to the peptidase S41A family
IA04_RS11055	COG2333	competence protein COMEC
IA04_RS11055	COG0658	competence protein
IA04_RS11060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IA04_RS11070	COG3104	oligopeptide transport
IA04_RS11075	COG3104	oligopeptide transport
IA04_RS11115	COG0793	Belongs to the peptidase S41A family
IA04_RS11125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IA04_RS11135	COG3852	Histidine kinase
IA04_RS11140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IA04_RS11150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IA04_RS11160	COG0519	Catalyzes the synthesis of GMP from XMP
IA04_RS11175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IA04_RS11180	COG1968	undecaprenyl-diphosphatase activity
IA04_RS11190	COG2177	Part of the ABC transporter FtsEX involved in
IA04_RS11200	COG0671	phosphoesterase, PA-phosphatase related
IA04_RS11205	COG0495	leucyl-tRNA aminoacylation
IA04_RS11220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IA04_RS11230	COG0823	Involved in the tonB-independent uptake of proteins
IA04_RS11230	COG1506	peptidase
IA04_RS11245	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IA04_RS11250	COG1522	sequence-specific DNA binding
IA04_RS11260	COG2363	Small membrane protein
IA04_RS11265	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IA04_RS11270	COG0594	ribonuclease P activity
IA04_RS11275	COG0439	Biotin carboxylase
IA04_RS11280	COG0511	ligase activity, forming carbon-carbon bonds
IA04_RS11285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IA04_RS11290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IA04_RS11300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IA04_RS11305	COG0307	riboflavin synthase, alpha
IA04_RS11320	COG2151	metal-sulfur cluster biosynthetic enzyme
IA04_RS11325	COG2166	iron-sulfur cluster assembly
IA04_RS11335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IA04_RS11345	COG0719	Fe-S assembly protein
IA04_RS11350	COG0396	ATPase activity
IA04_RS11355	COG0719	Fe-S assembly protein
IA04_RS11360	COG0316	Belongs to the HesB IscA family
IA04_RS11365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IA04_RS11385	COG0633	Ferredoxin
IA04_RS11430	COG0567	Dehydrogenase, E1 component
IA04_RS11460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IA04_RS11470	COG0138	bifunctional purine biosynthesis protein purh
IA04_RS11475	COG1077	Cell shape determining protein MreB Mrl
IA04_RS11490	COG0768	penicillin binding
IA04_RS11495	COG0772	Belongs to the SEDS family
IA04_RS11535	COG0423	glycine-tRNA ligase activity
IA04_RS11540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IA04_RS11560	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IA04_RS11575	COG0758	DNA mediated transformation
IA04_RS11585	COG1607	acyl-coa hydrolase
IA04_RS11620	COG4115	mRNA cleavage
IA04_RS11625	COG2161	toxin-antitoxin pair type II binding
IA04_RS11635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IA04_RS11640	COG0756	dUTP diphosphatase activity
IA04_RS11660	COG4264	IucA IucC family
IA04_RS11665	COG1181	Belongs to the D-alanine--D-alanine ligase family
IA04_RS11665	COG2918	glutathione biosynthetic process
IA04_RS11675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IA04_RS11680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IA04_RS11685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IA04_RS11690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IA04_RS11695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IA04_RS11700	COG0356	it plays a direct role in the translocation of protons across the membrane
IA04_RS11735	COG0859	PFAM glycosyl transferase family 9
IA04_RS11745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IA04_RS11760	COG0151	Belongs to the GarS family
IA04_RS11770	COG1215	transferase activity, transferring glycosyl groups
IA04_RS11780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IA04_RS11815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IA04_RS11820	COG2183	response to ionizing radiation
IA04_RS11845	COG0557	exoribonuclease II activity
IA04_RS11895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IA04_RS11905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IA04_RS11910	COG0445	tRNA wobble uridine modification
IA04_RS11915	COG2226	methyltransferase
IA04_RS11930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IA04_RS11950	COG0470	DNA polymerase III
IA04_RS12095	COG1216	Glycosyl transferase, family 2