locus-tag class description H0H25_RS00030 ENOG4105C22 threonyL-tRNA synthetase H0H25_RS00035 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H0H25_RS00040 ENOG4105VJV 50s ribosomal protein L35 H0H25_RS00045 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) H0H25_RS00065 ENOG4105C26 Dehydrogenase H0H25_RS00070 ENOG4105C34 Pseudouridine synthase H0H25_RS00075 ENOG4105CN1 protease H0H25_RS00080 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) H0H25_RS00085 ENOG4105EJQ L-serine dehydratase H0H25_RS00090 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H0H25_RS00125 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H0H25_RS00130 ENOG41080WS Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) H0H25_RS00155 ENOG4105CUG Oligopeptidase b H0H25_RS00160 ENOG4107RTD sua5 ycio yrdc ywlc family protein H0H25_RS00185 ENOG4105CFG Acts as a chaperone (By similarity) H0H25_RS00235 ENOG4107QKV phosphomannomutase H0H25_RS00260 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H0H25_RS00275 ENOG4108URH decarboxylase H0H25_RS00285 ENOG4108VVK transcriptional Regulator, AsnC H0H25_RS00315 ENOG4105C84 Histidine ammonia-lyase H0H25_RS00320 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) H0H25_RS00330 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) H0H25_RS00335 ENOG4105CDY transcriptional regulatory protein H0H25_RS00340 ENOG4105BZ1 (ABC) transporter H0H25_RS00360 ENOG4105CHU acetyl-coa acetyltransferase H0H25_RS00365 ENOG4107SN7 NLP P60 protein H0H25_RS00370 ENOG4105KIR Thiol-disulfide oxidoreductase dcc H0H25_RS00380 ENOG4107QJT sodium dicarboxylate symporter H0H25_RS00385 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H0H25_RS00395 ENOG410811B TRANSCRIPTIONal H0H25_RS00400 ENOG4105CPK Glycosyl transferase (Group 1 H0H25_RS00405 ENOG4105EXC Acyl-transferase H0H25_RS00420 ENOG4105D17 glycoside hydrolase, family 3 domain protein H0H25_RS00430 ENOG4105DF6 Fe-S oxidoreductase H0H25_RS00440 ENOG4105DF6 Fe-S oxidoreductase H0H25_RS00450 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H0H25_RS00480 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) H0H25_RS00485 ENOG4107VMU Membrane H0H25_RS00490 ENOG4105CGZ zinc metallopeptidase H0H25_RS00515 ENOG4105C8Y Acetylornithine aminotransferase H0H25_RS00540 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) H0H25_RS00565 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H0H25_RS00580 ENOG4105KWG Pfam:DUF1696 H0H25_RS00585 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate H0H25_RS00600 ENOG4105EE5 Membrane protein terC H0H25_RS00605 ENOG4108K8S endonuclease I H0H25_RS00615 ENOG4105CPP Dehydrogenase, E1 component H0H25_RS00620 ENOG4105D1Q UPF0246 protein H0H25_RS00625 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H0H25_RS00635 ENOG4105WH1 Two component transcriptional regulator luxr family H0H25_RS00670 ENOG4107QI6 Cysteine desulfurase H0H25_RS00680 ENOG4107QN2 dihydrolipoyl dehydrogenase H0H25_RS00695 ENOG4105IJJ transcriptional regulator, crp fnr family H0H25_RS00730 ENOG4108K8S endonuclease I H0H25_RS00785 ENOG4105CXB phosphoribosylaminoimidazole synthetase H0H25_RS00800 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H0H25_RS00810 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) H0H25_RS00855 ENOG4105ECP epimerase H0H25_RS00860 ENOG4107XPB Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ H0H25_RS00865 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H0H25_RS00870 ENOG4108IUX (ABC) transporter H0H25_RS00875 ENOG4105RHA ABC transporter, permease H0H25_RS00880 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0H25_RS00900 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) H0H25_RS00905 ENOG41062IR nudix hydrolase H0H25_RS00910 ENOG4105C1J atp-dependent rna helicase H0H25_RS00920 ENOG4105KA0 thioesterase Superfamily protein H0H25_RS00935 ENOG4105FJR Lmbe family H0H25_RS00945 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) H0H25_RS00950 ENOG4105CPF Cell wall formation (By similarity) H0H25_RS00960 ENOG4105C34 Pseudouridine synthase H0H25_RS00965 ENOG4105IIU Aminopeptidase H0H25_RS00970 ENOG4105DF5 DNA topoisomerase IV, subunit A H0H25_RS00995 ENOG4105C3G gtp-binding protein H0H25_RS01005 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H0H25_RS01015 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) H0H25_RS01020 ENOG4108JQ1 Dehydrogenase H0H25_RS01045 ENOG4105EUJ GTP cyclohydrolase i H0H25_RS01050 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) H0H25_RS01055 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H0H25_RS01065 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) H0H25_RS01070 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 H0H25_RS01075 ENOG4105EMN RNA polymerase sigma factor H0H25_RS01095 ENOG4105DFH Transport of potassium into the cell (By similarity) H0H25_RS01100 ENOG4105FFC UPF0187 protein H0H25_RS01115 ENOG4105C3M thioredoxin reductase H0H25_RS01120 ENOG4105CDU Replicative dna helicase H0H25_RS01125 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) H0H25_RS01140 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) H0H25_RS01160 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme H0H25_RS01165 ENOG4105KNE Phosphatidate cytidylyltransferase H0H25_RS01175 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H0H25_RS01180 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) H0H25_RS01185 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase H0H25_RS01190 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) H0H25_RS01195 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) H0H25_RS01200 ENOG4105C8N cysteinyl-tRNA synthetase H0H25_RS01205 ENOG4105EUJ GTP cyclohydrolase i H0H25_RS01235 ENOG4105C7S Dehydrogenase H0H25_RS01245 ENOG4105C5H ABC transporter H0H25_RS01265 ENOG4105C19 ABC transporter H0H25_RS01280 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving H0H25_RS01290 ENOG4105CA0 peroxidase H0H25_RS01310 ENOG4105CQB FAD linked oxidase domain protein H0H25_RS01315 ENOG4105EU0 Major facilitator Superfamily H0H25_RS01335 ENOG4107QI1 Mate efflux family protein H0H25_RS01340 ENOG4105CA0 peroxidase H0H25_RS01350 ENOG4105CSR polyphosphate kinase 2 H0H25_RS01370 ENOG4105C9U ATP-dependent DNA helicase RecQ H0H25_RS01385 ENOG4105C5H ABC transporter H0H25_RS01395 ENOG41074FQ H0H25_RS01440 ENOG4105CP2 von willebrand factor, type a H0H25_RS01465 ENOG4105DU1 integral membrane protein, terc H0H25_RS01470 ENOG4109015 Biopolymer transport protein exbD tolR H0H25_RS01480 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H0H25_RS01490 ENOG4108EF6 Proline imino-peptidase H0H25_RS01495 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) H0H25_RS01500 ENOG4105SKN orotidine 5''-phosphate decarboxylase H0H25_RS01505 ENOG4105VIE preprotein translocase, subunit YajC H0H25_RS01515 ENOG4107R6T Involved in the transcription termination process (By similarity) H0H25_RS01520 ENOG4107RDP Dehydrogenase H0H25_RS01525 ENOG4105BZ1 (ABC) transporter H0H25_RS01535 ENOG4108Z7R Chaperone CsaA H0H25_RS01540 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0H25_RS01550 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0H25_RS01555 ENOG4105CAQ asparagine synthetase H0H25_RS01565 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H0H25_RS01575 ENOG4107ENK receptor H0H25_RS01590 ENOG4105CAK Cell division ATP-binding protein ftsE H0H25_RS01600 ENOG4105K8Z Phage shock protein H0H25_RS01620 ENOG4105CRQ synthase (Component I) H0H25_RS01625 ENOG4105DDQ anthranilate synthase H0H25_RS01630 ENOG4108I0Q anthranilate phosphoribosyltransferase H0H25_RS01635 ENOG4105DK0 Indole-3-glycerol phosphate synthase H0H25_RS01640 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase H0H25_RS01645 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) H0H25_RS01650 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) H0H25_RS01660 ENOG4105U5Y Transcriptional regulator H0H25_RS01675 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0H25_RS01680 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase H0H25_RS01705 ENOG41068WN H0H25_RS01810 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H0H25_RS01820 ENOG4105QNR S1 RNA binding domain protein H0H25_RS01825 ENOG4105CI3 gtp-binding protein typa H0H25_RS01855 ENOG4105RA3 Binds directly to 16S ribosomal RNA (By similarity) H0H25_RS01870 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) H0H25_RS01885 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) H0H25_RS01920 ENOG41074B2 UPF0747 protein H0H25_RS01925 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) H0H25_RS01935 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H0H25_RS01950 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H0H25_RS01970 ENOG4108V06 Glutathione peroxidase H0H25_RS01975 ENOG4105CRE cytochrome C H0H25_RS01995 ENOG4108Z03 MAF-like protein H0H25_RS02000 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) H0H25_RS02005 ENOG4105BZ1 (ABC) transporter H0H25_RS02010 ENOG4105EEI dihydropteroate synthase H0H25_RS02025 ENOG4107ZT5 Thiol disulfide interchange protein H0H25_RS02030 ENOG4105CP7 Triose-phosphate isomerase H0H25_RS02035 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H0H25_RS02045 ENOG41083ND 50S ribosomal protein L33 H0H25_RS02050 ENOG4105KDC 50s ribosomal protein l28 H0H25_RS02055 ENOG4105CEV competence damage-inducible protein H0H25_RS02070 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase H0H25_RS02075 ENOG4108IRC dna polymerase iii H0H25_RS02085 ENOG4105VEJ Heat shock protein H0H25_RS02090 ENOG4105FQ6 thiopurine methyltransferase H0H25_RS02095 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) H0H25_RS02100 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) H0H25_RS02185 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) H0H25_RS02190 ENOG4108YZT Adenosylcobinamide kinase H0H25_RS02205 ENOG4105EHG Permease protein H0H25_RS02225 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) H0H25_RS02235 ENOG4105BZU Histidine kinase H0H25_RS02245 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) H0H25_RS02255 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) H0H25_RS02340 ENOG4105BZU Histidine kinase H0H25_RS02360 ENOG4105D05 Receptor H0H25_RS02375 ENOG4105C75 arginyL-tRNA synthetase H0H25_RS02395 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H0H25_RS02410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0H25_RS02425 ENOG4108ZG0 Ompa motb domain protein H0H25_RS02435 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H0H25_RS02470 ENOG4105DY9 regulatoR H0H25_RS02505 ENOG4105CN9 Peptidase m42 family protein H0H25_RS02510 ENOG4107QWK SAICAR synthetase H0H25_RS02520 ENOG4105C9A Phoh family H0H25_RS02575 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H0H25_RS02580 ENOG4105C1J atp-dependent rna helicase H0H25_RS02590 ENOG4105CD3 dihydroorotase H0H25_RS02610 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H0H25_RS02620 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H0H25_RS02625 ENOG4105CSM endonuclease III H0H25_RS02650 ENOG4108MMM RNA Polymerase H0H25_RS02655 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H0H25_RS02670 ENOG4105DDG Cyanophycinase H0H25_RS02680 ENOG4105C5Z peptidase H0H25_RS02730 ENOG4105D5P Methylmalonyl-coA mutase H0H25_RS02745 ENOG4105C3F Signal peptidase i H0H25_RS02750 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) H0H25_RS02760 ENOG4105FA0 parb-like partition protein H0H25_RS02765 ENOG4107QJE Chromosome Partitioning Protein H0H25_RS02770 ENOG4105K6S Short-chain dehydrogenase reductase Sdr H0H25_RS02775 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H0H25_RS02785 ENOG41081WG 50s ribosomal protein l31 H0H25_RS02795 ENOG4105CKK Glycosyl transferase, family 2 H0H25_RS02805 ENOG4105BZ1 (ABC) transporter H0H25_RS02825 ENOG4105DR5 peptidase H0H25_RS02845 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) H0H25_RS02850 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) H0H25_RS02880 ENOG4105C59 p-type ATPase H0H25_RS02895 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i H0H25_RS02905 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) H0H25_RS02910 ENOG4105C58 cytochrome c oxidase accessory protein ccog H0H25_RS02935 ENOG4108I0Z Aconitate hydratase H0H25_RS02940 ENOG410904N short-chain dehydrogenase reductase H0H25_RS02945 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H0H25_RS02950 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H0H25_RS02955 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H0H25_RS02960 ENOG4105RWF major outer membrane protein OmpA H0H25_RS02990 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) H0H25_RS03005 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H0H25_RS03010 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H0H25_RS03015 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) H0H25_RS03020 ENOG4107VNI ribosomal protein l10 H0H25_RS03025 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) H0H25_RS03030 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) H0H25_RS03050 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) H0H25_RS03070 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA H0H25_RS03075 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0H25_RS03080 ENOG41083X6 30S ribosomal protein S21 H0H25_RS03085 ENOG4105C1G acyl-Coa dehydrogenase H0H25_RS03100 ENOG4107QRG dna polymerase iii H0H25_RS03105 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) H0H25_RS03130 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H0H25_RS03135 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) H0H25_RS03140 ENOG4105CRK lysyL-tRNA synthetase H0H25_RS03150 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase H0H25_RS03160 ENOG4105K6H D-cysteine desulfhydrase H0H25_RS03170 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) H0H25_RS03195 ENOG4105HHA aminodeoxychorismate lyase H0H25_RS03205 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) H0H25_RS03210 ENOG4105C0H protease H0H25_RS03220 ENOG4107TT5 NLP P60 protein H0H25_RS03225 ENOG4105EGD dinuclear metal center protein, YbgI family H0H25_RS03240 ENOG4105FE9 pseudouridine synthase H0H25_RS03260 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase H0H25_RS03275 ENOG4105DZ0 fad dependent oxidoreductase H0H25_RS03295 ENOG4105C9U ATP-dependent DNA helicase RecQ H0H25_RS03300 ENOG4105C2X Arabinose 5-phosphate isomerase H0H25_RS03305 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H0H25_RS03315 ENOG4108IUZ ABC transporter H0H25_RS03370 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB H0H25_RS03385 ENOG4108RJ9 Glycosyl transferase, family 2 H0H25_RS03395 ENOG4105D7W serine acetyltransferase H0H25_RS03405 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase H0H25_RS03410 ENOG4105D2T synthase H0H25_RS03415 ENOG4105F0R Cytidylyltransferase H0H25_RS03440 ENOG4105JNK Glycosyl transferase (Group 1 H0H25_RS03450 ENOG4107S6X Glycosyl transferase, family 2 H0H25_RS03455 ENOG4107S6X Glycosyl transferase, family 2 H0H25_RS03465 ENOG4105J5G Transferase hexapeptide repeat containing protein H0H25_RS03470 ENOG4105EY8 ABC transporter H0H25_RS03475 ENOG4105MFV ABC-2 type transporter H0H25_RS03495 ENOG4108RB3 Capsular polysaccharide biosynthesis protein H0H25_RS03500 ENOG4108QV3 biosynthesis protein H0H25_RS03515 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H0H25_RS03540 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H0H25_RS03545 ENOG4105D3Q Sugar transferase H0H25_RS03550 ENOG4106CD9 glycosyl transferase group 1 H0H25_RS03555 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H0H25_RS03570 ENOG4105C5E polysaccharide biosynthesis protein H0H25_RS03595 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H0H25_RS03600 ENOG4105C1B dTDP-glucose 4-6-dehydratase H0H25_RS03605 ENOG4105C6Y Udp-glucose 6-dehydrogenase H0H25_RS03610 ENOG4107QQG Dehydrogenase H0H25_RS03620 ENOG4108QV3 biosynthesis protein H0H25_RS03630 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) H0H25_RS03635 ENOG4107RJ1 sodium solute H0H25_RS03645 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H0H25_RS03670 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) H0H25_RS03680 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H0H25_RS03685 ENOG4108ZT0 50S ribosomal protein l17 H0H25_RS03690 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) H0H25_RS03695 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) H0H25_RS03700 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) H0H25_RS03705 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits H0H25_RS03710 ENOG410864M 50S ribosomal protein L36 H0H25_RS03715 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) H0H25_RS03720 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H0H25_RS03725 ENOG4107XE9 Binds to the 23S rRNA (By similarity) H0H25_RS03730 ENOG41084HK 50S ribosomal protein L30 H0H25_RS03735 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) H0H25_RS03740 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) H0H25_RS03745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) H0H25_RS03750 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) H0H25_RS03755 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) H0H25_RS03760 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits H0H25_RS03765 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H0H25_RS03770 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) H0H25_RS03775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal H0H25_RS03785 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) H0H25_RS03790 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) H0H25_RS03795 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) H0H25_RS03800 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) H0H25_RS03805 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity H0H25_RS03810 ENOG41082S5 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) H0H25_RS03815 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) H0H25_RS03820 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) H0H25_RS03825 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) H0H25_RS03830 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) H0H25_RS03835 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) H0H25_RS03840 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) H0H25_RS03860 ENOG4105C2N RNA methyltransferase TrmH family group 3 H0H25_RS03870 ENOG4105D1H recombination factor protein RarA H0H25_RS03885 ENOG4105W5Q DNA repair protein (RadC H0H25_RS03890 ENOG4105DFU Cell wall formation (By similarity) H0H25_RS03900 ENOG4105CZH peptidase H0H25_RS03905 ENOG4109066 lysm domain bon superfamily protein H0H25_RS03910 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control H0H25_RS03920 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) H0H25_RS03925 ENOG4108UGV hypoxanthine phosphoribosyltransferase H0H25_RS03935 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H0H25_RS03940 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H0H25_RS03945 ENOG4105DGW oligopeptidase A H0H25_RS03980 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor H0H25_RS04005 ENOG4107R8N Glycosyl transferase, family 2 H0H25_RS04015 ENOG4105DHJ ABC, transporter H0H25_RS04030 ENOG4105GPY SprT protein H0H25_RS04035 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H0H25_RS04045 ENOG4108JYK Dehydrogenase H0H25_RS04050 ENOG4105KG3 cytidine deaminase H0H25_RS04070 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) H0H25_RS04115 ENOG4105EHZ conserved protein UCP016719 H0H25_RS04135 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H0H25_RS04195 ENOG4105D7A ATP-binding protein H0H25_RS04200 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) H0H25_RS04205 ENOG4105CUJ penicillin amidase H0H25_RS04210 ENOG4105CYW agmatinase H0H25_RS04215 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) H0H25_RS04225 ENOG4105K46 50S ribosomal protein l27 H0H25_RS04230 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) H0H25_RS04235 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0H25_RS04240 ENOG4105C8S subunit m H0H25_RS04250 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0H25_RS04255 ENOG4107YX3 NADH dehydrogenase subunit j H0H25_RS04260 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0H25_RS04265 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) H0H25_RS04290 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0H25_RS04295 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H0H25_RS04300 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0H25_RS04305 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain H0H25_RS04310 ENOG4105DN3 alpha-2-macroglobulin domain protein H0H25_RS04315 ENOG4108JQC penicillin-binding protein 1A H0H25_RS04350 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) H0H25_RS04370 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) H0H25_RS04385 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase H0H25_RS04390 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0H25_RS04395 ENOG4105C5S asparaginyl-tRNA synthetase H0H25_RS04405 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H0H25_RS04410 ENOG4105DZS Phenylacetate-CoA ligase H0H25_RS04440 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H0H25_RS04470 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0H25_RS04480 ENOG4107IQ5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H0H25_RS04505 ENOG4105CJ1 ABC, transporter H0H25_RS04535 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) H0H25_RS04540 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H0H25_RS04550 ENOG4107VFM Dehydrogenase H0H25_RS04565 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0H25_RS04570 ENOG4105CHR reductase H0H25_RS04590 ENOG4105F8V Hydrolase, tatD family H0H25_RS04600 ENOG4105HDK L-asparaginase H0H25_RS04650 ENOG4107QHF type ii secretion system protein e H0H25_RS04660 ENOG4106855 Competence protein H0H25_RS04695 ENOG4108UV1 cellular component movement H0H25_RS04775 ENOG4105C26 Dehydrogenase H0H25_RS04780 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H0H25_RS04785 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0H25_RS04790 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H0H25_RS04795 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H0H25_RS04800 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H25_RS04810 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) H0H25_RS04815 ENOG4105CN1 protease H0H25_RS04820 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 H0H25_RS04825 ENOG4105MH8 Thioredoxin disulfide isomerase H0H25_RS04835 ENOG4105DUX Transporter H0H25_RS04840 ENOG4105DUX Transporter H0H25_RS04890 ENOG4105CN1 protease H0H25_RS04900 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase H0H25_RS04910 ENOG4105BZU Histidine kinase H0H25_RS04915 ENOG4107XWI flavin reductase domain protein, FMN-binding H0H25_RS04925 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) H0H25_RS04935 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H0H25_RS04950 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) H0H25_RS04955 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) H0H25_RS04965 ENOG4107RJ9 Cell division protein FtsX H0H25_RS04975 ENOG4106CKV Pap2 superfamily protein H0H25_RS04980 ENOG4105C8T Leucyl-tRNA synthetase H0H25_RS04995 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H0H25_RS05005 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein H0H25_RS05020 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) H0H25_RS05025 ENOG4108VVK transcriptional Regulator, AsnC H0H25_RS05035 ENOG4105M08 Membrane H0H25_RS05040 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase H0H25_RS05045 ENOG4105WG6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) H0H25_RS05050 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H0H25_RS05055 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H0H25_RS05060 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) H0H25_RS05065 ENOG4105WXV 50S ribosomal protein L32 H0H25_RS05075 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) H0H25_RS05080 ENOG4108R6K riboflavin synthase, subunit alpha H0H25_RS05095 ENOG4105VG1 fes assembly suf system protein H0H25_RS05100 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) H0H25_RS05110 ENOG4105C9B Cysteine desulfurase H0H25_RS05135 ENOG4108YX9 iron--sulfur cluster insertion protein erpA H0H25_RS05140 ENOG4105C8F Beta-lactamase domain protein H0H25_RS05160 ENOG4108ZIT Ferredoxin, 2FE-2S H0H25_RS05205 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H0H25_RS05210 ENOG4105C7S Dehydrogenase H0H25_RS05220 ENOG4105UYK outer membrane protein a H0H25_RS05235 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H0H25_RS05245 ENOG4105DC1 bifunctional purine biosynthesis protein purh H0H25_RS05250 ENOG4105DFF Rod shape-determining protein mreb H0H25_RS05265 ENOG4105CJN penicillin-binding protein H0H25_RS05270 ENOG4105CNI cell division protein FtsW H0H25_RS05315 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) H0H25_RS05320 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) H0H25_RS05340 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) H0H25_RS05360 ENOG4105C79 DNA protecting protein DprA H0H25_RS05370 ENOG4108S4H thioesterase Superfamily protein H0H25_RS05405 ENOG4105KRQ Addiction module toxin, Txe YoeB family H0H25_RS05420 ENOG4108J3C UTP-glucose-1-phosphate uridylyltransferase H0H25_RS05425 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H0H25_RS05455 ENOG4105D9M gamma-glutamylcysteine synthetase H0H25_RS05460 ENOG4105CNM Receptor H0H25_RS05465 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) H0H25_RS05470 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) H0H25_RS05475 ENOG4107Z4P F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) H0H25_RS05480 ENOG4107Z65 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) H0H25_RS05485 ENOG410842R atp synthase H0H25_RS05490 ENOG4107WJT it plays a direct role in the translocation of protons across the membrane (By similarity) H0H25_RS05525 ENOG4105DKP glycosyl transferase, family 9 H0H25_RS05535 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) H0H25_RS05550 ENOG4105C12 Phosphoribosylglycinamide synthetase H0H25_RS05570 ENOG4108IAJ Nad-dependent epimerase dehydratase H0H25_RS05580 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H0H25_RS05605 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H0H25_RS05610 ENOG4105BZM domain protein H0H25_RS05620 ENOG4105PGM cation diffusion facilitator family transporter H0H25_RS05635 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H0H25_RS05685 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) H0H25_RS05695 ENOG41080AX Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) H0H25_RS05700 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) H0H25_RS05705 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H0H25_RS05740 ENOG4107QRG dna polymerase iii H0H25_RS05775 ENOG4105BZA Phosphoglycerate kinase H0H25_RS05785 ENOG4107YB6 acetyltransferase, (GNAT) family H0H25_RS05800 ENOG4105MA4 psp1 domain protein H0H25_RS05805 ENOG410647Z gliding motility-associated lipoprotein GldH H0H25_RS05810 ENOG4108JQC penicillin-binding protein 1A H0H25_RS05815 ENOG4107QP7 CoA-transferase subunit A H0H25_RS05820 ENOG4105CVR type I restriction-modification system H0H25_RS05860 ENOG4105D52 delta-aminolevulinic acid dehydratase H0H25_RS05870 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) H0H25_RS05890 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) H0H25_RS05905 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) H0H25_RS05910 ENOG4105WPR Transcriptional regulator, ARAC family H0H25_RS05915 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) H0H25_RS05925 ENOG4108HWS Histidine kinase H0H25_RS05930 ENOG4105E39 Enoyl-CoA hydratase H0H25_RS05950 ENOG4108Y6J UPF0403 protein H0H25_RS05960 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) H0H25_RS05975 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H0H25_RS05980 ENOG41080R2 UPF0102 protein H0H25_RS05985 ENOG4105CPC Aldo Keto reductase H0H25_RS05990 ENOG4105ER2 Ompa motb domain protein H0H25_RS05995 ENOG4105CGK Exodeoxyribonuclease III H0H25_RS06005 ENOG4108JQ1 Dehydrogenase H0H25_RS06020 ENOG4105CJW magnesium transporter H0H25_RS06025 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) H0H25_RS06045 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) H0H25_RS06065 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) H0H25_RS06115 ENOG4105C9K Endothelin-converting enzyme 1 H0H25_RS06125 ENOG4108KF3 Electron transport protein SCO1 SenC H0H25_RS06135 ENOG4105CE1 Ferrous iron transport protein b H0H25_RS06155 ENOG4105E33 succinate dehydrogenase H0H25_RS06175 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase H0H25_RS06195 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H0H25_RS06210 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) H0H25_RS06220 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) H0H25_RS06230 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H0H25_RS06245 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) H0H25_RS06260 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H0H25_RS06285 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) H0H25_RS06340 ENOG4105C7R Atpase associated with various cellular activities aaa_3 H0H25_RS06360 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA H0H25_RS06365 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase H0H25_RS06370 ENOG4108I6A alcohol dehydrogenase H0H25_RS06375 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) H0H25_RS06385 ENOG4107QP8 phosphohexose isomerase H0H25_RS06390 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) H0H25_RS06425 ENOG4105DC7 peptidase M24 H0H25_RS06445 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H0H25_RS06455 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation H0H25_RS06465 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) H0H25_RS06480 ENOG4105CD3 dihydroorotase H0H25_RS06485 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) H0H25_RS06595 ENOG4108YZN class I peptide chain release factor H0H25_RS06605 ENOG4106Z1T Nicotinamide Mononucleotide Transporter H0H25_RS06610 ENOG4108RCS geranylgeranylglyceryl phosphate synthase H0H25_RS06620 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) H0H25_RS06630 ENOG4105EXW epimerase dehydratase H0H25_RS06635 ENOG4108JA2 transcriptioN-repair coupling factor H0H25_RS06645 ENOG4105K6T rare lipoprotein A H0H25_RS06655 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase H0H25_RS06665 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) H0H25_RS06670 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H0H25_RS06675 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H0H25_RS06680 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0H25_RS06685 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) H0H25_RS06715 ENOG4105CSA Coproporphyrinogen iii oxidase H0H25_RS06720 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) H0H25_RS06770 ENOG4107T7F This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) H0H25_RS06775 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H0H25_RS06785 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) H0H25_RS06790 ENOG4105D78 K07001 NTE family protein H0H25_RS06795 ENOG4105CUB amino acid H0H25_RS06800 ENOG4105F1J Homogentisate 1,2-dioxygenase H0H25_RS06805 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase H0H25_RS06815 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) H0H25_RS06825 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) H0H25_RS06830 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin H0H25_RS06835 ENOG41061HS cysteine-type endopeptidase activity H0H25_RS06840 ENOG4105DTN riboflavin biosynthesis protein ribF H0H25_RS06845 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) H0H25_RS06860 ENOG4108ZVT methylmalonyl-coA epimerase H0H25_RS06865 ENOG4105H4N Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) H0H25_RS06875 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) H0H25_RS06900 ENOG4105F5P DNA-damage-inducible protein d H0H25_RS06910 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) H0H25_RS06915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) H0H25_RS06920 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase H0H25_RS06925 ENOG4105CHM Aminotransferase H0H25_RS06950 ENOG4105CFH Aspartokinase H0H25_RS06955 ENOG4105DWV Homoserine O-trans-acetylase H0H25_RS06975 ENOG4105K63 Thioredoxin H0H25_RS06985 ENOG4105ZMH deoxynucleoside kinase H0H25_RS07025 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP H0H25_RS07030 ENOG41060VI Involved in DNA repair and RecF pathway recombination (By similarity) H0H25_RS07040 ENOG4107R37 Glutamate dehydrogenase H0H25_RS07060 ENOG4107ZT5 Thiol disulfide interchange protein H0H25_RS07065 ENOG4105C9M aspartyl-trna synthetase H0H25_RS07070 ENOG4105VEQ Cold shock protein H0H25_RS07075 ENOG4108Z6B deaminase H0H25_RS07085 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) H0H25_RS07140 ENOG4105C2M dna polymerase I H0H25_RS07150 ENOG4105K63 Thioredoxin H0H25_RS07185 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 H0H25_RS07190 ENOG4108K0D peptidase, M48 H0H25_RS07200 ENOG4105CFH Aspartokinase H0H25_RS07225 ENOG4105CBX hi0933 family H0H25_RS07230 ENOG4105KAV tspo and mbr like protein H0H25_RS07250 ENOG4105FE9 pseudouridine synthase H0H25_RS07280 ENOG4105RWF major outer membrane protein OmpA H0H25_RS07285 ENOG4108IDZ Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) H0H25_RS07290 ENOG4105D2N Aldolase H0H25_RS07300 ENOG4105C2N RNA methyltransferase TrmH family group 3 H0H25_RS07310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) H0H25_RS07315 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H0H25_RS07340 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) H0H25_RS07350 ENOG4105C10 Electron transfer flavoprotein H0H25_RS07355 ENOG4105BZJ Electron transfer flavoprotein H0H25_RS07370 ENOG4105F0N pyrophosphate phospho-hydrolase H0H25_RS07385 ENOG4105C0B DNA polymerase III (alpha subunit) H0H25_RS07400 ENOG4105K5M 30s ribosomal protein S16 H0H25_RS07405 ENOG4107YAY An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) H0H25_RS07410 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) H0H25_RS07415 ENOG4105C1G acyl-Coa dehydrogenase H0H25_RS07420 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H0H25_RS07450 ENOG4105C28 cystathionine H0H25_RS07470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0H25_RS07475 ENOG4105BZU Histidine kinase H0H25_RS07485 ENOG4105DJH phosphate H0H25_RS07495 ENOG4105E2Z phosphate ABC transporter (Permease H0H25_RS07500 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H0H25_RS07505 ENOG4108UTW Plays a role in the regulation of phosphate uptake H0H25_RS07510 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H0H25_RS07520 ENOG4107UGT Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) H0H25_RS07545 ENOG4107SFQ iron-sulfur binding H0H25_RS07570 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) H0H25_RS07575 ENOG4105BZ9 Cytochrome C oxidase, subunit I H0H25_RS07590 ENOG4105CZH peptidase H0H25_RS07630 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H0H25_RS07635 ENOG4105KT5 UmuD protein H0H25_RS07660 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) H0H25_RS07670 ENOG4105C2N RNA methyltransferase TrmH family group 3 H0H25_RS07695 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H0H25_RS07705 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase H0H25_RS07710 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H0H25_RS07715 ENOG4105CMR udp-glucose 4-epimerase H0H25_RS07725 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H0H25_RS07740 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR H0H25_RS07755 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) H0H25_RS07760 ENOG4105C26 Dehydrogenase H0H25_RS07770 ENOG4105NWN ApaG protein H0H25_RS07800 ENOG4108JJA ABC, transporter H0H25_RS07810 ENOG4105CYC Transferase H0H25_RS07840 ENOG4105DWF phosphomethylpyrimidine kinase H0H25_RS07845 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) H0H25_RS07850 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) H0H25_RS07855 ENOG4105D41 biosynthesis protein thiH H0H25_RS07860 ENOG4105D06 uba thif-type nad fad binding protein H0H25_RS07865 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) H0H25_RS07870 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) H0H25_RS07920 ENOG4105C7B Threonine dehydratase H0H25_RS07925 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase H0H25_RS07930 ENOG4108ZP8 Acetolactate synthase small subunit H0H25_RS07935 ENOG4105C7K acetolactate synthase H0H25_RS07940 ENOG4105C01 Dihydroxy-acid dehydratase H0H25_RS07945 ENOG4105CM2 brancheD-chain amino acid aminotransferase H0H25_RS07965 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) H0H25_RS07970 ENOG4105CE9 30S ribosomal protein S2 H0H25_RS07975 ENOG4108UJD 30S ribosomal protein S9 H0H25_RS07980 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) H0H25_RS07985 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0H25_RS08000 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H0H25_RS08015 ENOG4105CN1 protease H0H25_RS08035 ENOG4107YZX Universal stress protein H0H25_RS08040 ENOG41090IP Required for maturation of 30S ribosomal subunits (By similarity) H0H25_RS08045 ENOG4105CHV Transcription elongation factor NusA H0H25_RS08050 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) H0H25_RS08160 ENOG4105FQP Beta-lactamase H0H25_RS08190 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H0H25_RS08250 ENOG4105ESI atpase involved in dna repair H0H25_RS08255 ENOG4108NEV two component transcriptional regulator, LytTR family H0H25_RS08270 ENOG4106K8T Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA H0H25_RS08385 ENOG4105DVF Cytosine-specific methyltransferase H0H25_RS08495 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) H0H25_RS08505 ENOG4105DIT ErfK YbiS YcfS YnhG family protein H0H25_RS08525 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) H0H25_RS08545 ENOG4105D5Q Arginine ornithine antiporter H0H25_RS08550 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) H0H25_RS08555 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H0H25_RS08560 ENOG4105C6K Malic enzyme H0H25_RS08565 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) H0H25_RS08580 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) H0H25_RS08590 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) H0H25_RS08600 ENOG410624X efflux transporter, rnd family, mfp subunit H0H25_RS08620 ENOG4108SJC Membrane H0H25_RS08625 ENOG4108KF3 Electron transport protein SCO1 SenC H0H25_RS08650 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) H0H25_RS08655 ENOG41072GX Peptidase M22 Glycoprotease H0H25_RS08665 ENOG4105C7Z Conserved Protein H0H25_RS08680 ENOG4108Z0R Transferase H0H25_RS08685 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) H0H25_RS08705 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H0H25_RS08715 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) H0H25_RS08725 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) H0H25_RS08730 ENOG4105DVE abc transporter atp-binding protein H0H25_RS08745 ENOG41086DT Membrane protein of unknown function H0H25_RS08750 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation H0H25_RS08760 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) H0H25_RS08765 ENOG4108CSZ Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H0H25_RS08780 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs H0H25_RS08820 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H0H25_RS08825 ENOG4107ZHV Transcriptional regulator H0H25_RS08830 ENOG4107RA1 nh(3)-dependent nad( ) synthetase H0H25_RS08845 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) H0H25_RS08855 ENOG4107YM1 mraZ protein H0H25_RS08860 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) H0H25_RS08870 ENOG4105CJN penicillin-binding protein H0H25_RS08875 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H0H25_RS08880 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) H0H25_RS08890 ENOG4105CNI cell division protein FtsW H0H25_RS08895 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) H0H25_RS08900 ENOG4105DFU Cell wall formation (By similarity) H0H25_RS08910 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H0H25_RS08915 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H0H25_RS08920 ENOG4105KTH gatB Yqey H0H25_RS08940 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0H25_RS08950 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) H0H25_RS08955 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) H0H25_RS08960 ENOG4105CGD Nad-dependent epimerase dehydratase H0H25_RS08965 ENOG4105CVP deoxyribo-dipyrimidine photolyase H0H25_RS08970 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein H0H25_RS08980 ENOG4105CVP deoxyribo-dipyrimidine photolyase H0H25_RS09040 ENOG41077A9 carbonic anhydrase H0H25_RS09050 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H0H25_RS09060 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H0H25_RS09070 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H0H25_RS09080 ENOG4105CUT histidyl-tRNA synthetase H0H25_RS09085 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0H25_RS09095 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) H0H25_RS09115 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) H0H25_RS09135 ENOG4105C9U ATP-dependent DNA helicase RecQ H0H25_RS09140 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) H0H25_RS09150 ENOG4108UJU UPF0301 protein H0H25_RS09155 ENOG4105F0I Aminotransferase H0H25_RS09170 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H0H25_RS09180 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) H0H25_RS09200 ENOG4105CAQ asparagine synthetase H0H25_RS09205 ENOG4107R0I Cell wall formation (By similarity) H0H25_RS09210 ENOG4105E0A ABC, transporter H0H25_RS09215 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H0H25_RS09225 ENOG4105CGY Dna recombination protein H0H25_RS09235 ENOG4105NAU thioesterase Superfamily protein H0H25_RS09245 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H0H25_RS09250 ENOG4105VG0 50S ribosomal protein l34 H0H25_RS09260 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) H0H25_RS09270 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) H0H25_RS09290 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0H25_RS09295 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) H0H25_RS09330 ENOG4105E6M Sulphatase-modifying factor protein H0H25_RS09380 ENOG4105C5H ABC transporter H0H25_RS09405 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) H0H25_RS09410 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) H0H25_RS09435 ENOG4105CGP Urocanate hydratase H0H25_RS09475 ENOG4105BZ1 (ABC) transporter H0H25_RS09490 ENOG4105HA9 of methanol dehydrogenase type H0H25_RS09500 ENOG4108V0P LemA family H0H25_RS09510 ENOG4108K5P (LipO)protein H0H25_RS09515 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) H0H25_RS09520 ENOG4105D5P Methylmalonyl-coA mutase H0H25_RS09575 ENOG4105CIN aminoacyl-histidine dipeptidase H0H25_RS09580 ENOG4105C1G acyl-Coa dehydrogenase H0H25_RS09585 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) H0H25_RS09610 ENOG4105E0K tonB-dependent siderophore receptor H0H25_RS09615 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) H0H25_RS09625 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) H0H25_RS09635 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) H0H25_RS09650 ENOG4105DFA alanine racemase domain protein H0H25_RS09660 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H0H25_RS09665 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) H0H25_RS09670 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) H0H25_RS09675 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) H0H25_RS09685 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein H0H25_RS09705 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis H0H25_RS09715 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins H0H25_RS09720 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) H0H25_RS09725 ENOG4105VRT cytoplasmic protein H0H25_RS09745 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) H0H25_RS09750 ENOG4105SFS phosphoesterase RecJ domain protein H0H25_RS09760 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) H0H25_RS09765 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) H0H25_RS09785 ENOG41068WN H0H25_RS09790 ENOG4105VYA Uncharacterized conserved protein (DUF2132) H0H25_RS09795 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) H0H25_RS09800 ENOG4105DGW oligopeptidase A H0H25_RS09830 ENOG4108JJA ABC, transporter H0H25_RS09845 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) H0H25_RS09850 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) H0H25_RS09875 ENOG4105EN6 Membrane H0H25_RS09880 ENOG4108RWN rrna methyltransferase H0H25_RS09885 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0H25_RS09910 ENOG4105CKK Glycosyl transferase, family 2 H0H25_RS09915 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) H0H25_RS09930 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0H25_RS09935 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H0H25_RS09940 ENOG4107U9T Pfam:Ribonuclease_BN H0H25_RS09950 ENOG4105C25 Primosomal protein n' H0H25_RS09955 ENOG4105DY9 regulatoR H0H25_RS09960 ENOG41080B9 Binds together with S18 to 16S ribosomal RNA (By similarity) H0H25_RS09965 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H0H25_RS09970 ENOG4105K9Q Binds to the 23S rRNA (By similarity) H0H25_RS09980 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) H0H25_RS10000 ENOG4105RKW reductase (By H0H25_RS10005 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H0H25_RS10025 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H0H25_RS10030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) H0H25_RS10045 ENOG4105CGH 5'-nucleotidase H0H25_RS10065 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H0H25_RS10095 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) H0H25_RS10110 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H0H25_RS10115 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H0H25_RS10135 ENOG4107TPS domain protein H0H25_RS10150 ENOG4105C3M thioredoxin reductase H0H25_RS10180 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase H0H25_RS10185 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H0H25_RS10190 ENOG4107QTF adenylosuccinate lyase H0H25_RS10195 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H0H25_RS10220 ENOG4105WMR Protein CrcB homolog H0H25_RS10235 ENOG4105CXT aspartate transcarbamylase H0H25_RS10245 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H0H25_RS10250 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) H0H25_RS10260 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H0H25_RS10265 ENOG4105DG6 mannose-6-phosphate isomerase H0H25_RS10285 ENOG4105E0K tonB-dependent siderophore receptor H0H25_RS10310 ENOG4105CI2 imidazolone-5-propionate hydrolase H0H25_RS10315 ENOG4105D7N magnesium and cobalt transport protein CorA H0H25_RS10340 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) H0H25_RS10345 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) H0H25_RS10360 ENOG4105C8Y Acetylornithine aminotransferase H0H25_RS10370 ENOG4105E2X shikimate dehydrogenase H0H25_RS10375 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) H0H25_RS10390 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0H25_RS10395 ENOG4105C5H ABC transporter H0H25_RS10400 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin H0H25_RS10405 ENOG4105EA8 2-Nitropropane dioxygenase H0H25_RS10425 ENOG4105HFT AraC family transcriptional regulator H0H25_RS10435 ENOG4105DXN mazG family H0H25_RS10445 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) H0H25_RS10450 ENOG4105DWT malate dehydrogenase (quinone) H0H25_RS10455 ENOG4107ZNS Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) H0H25_RS10485 ENOG4105CUZ uba thif-type nad fad binding protein H0H25_RS10510 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) H0H25_RS10520 ENOG4105C5Q Transcriptional regulator H0H25_RS10530 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0H25_RS10535 ENOG4107QN2 dihydrolipoyl dehydrogenase H0H25_RS10540 ENOG4105EW9 transcriptional regulator AsnC family H0H25_RS10545 ENOG4105C28 cystathionine H0H25_RS10550 ENOG4105CUB amino acid H0H25_RS10560 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) H0H25_RS10565 ENOG4105D3R alkyl hydroperoxide reductase H0H25_RS10580 ENOG4105C1G acyl-Coa dehydrogenase H0H25_RS10585 ENOG4105CHU acetyl-coa acetyltransferase H0H25_RS10600 ENOG4105FS7 Transcriptional regulator H0H25_RS10605 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H0H25_RS10610 ENOG4108IQE Amp-dependent synthetase and ligase H0H25_RS10615 ENOG4105E0X reductase H0H25_RS10620 ENOG4105E0X reductase H0H25_RS10635 ENOG4105DEU major facilitator superfamily H0H25_RS10640 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H0H25_RS10650 ENOG4105CAT Cytidine monophosphate kinase H0H25_RS10655 ENOG4105EAA nucleoside H0H25_RS10675 ENOG4105D49 3-dehydroquinate synthase H0H25_RS10685 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) H0H25_RS10700 ENOG4108V0P LemA family H0H25_RS10705 ENOG4105C1J atp-dependent rna helicase H0H25_RS10710 ENOG41088SP formiminoglutamate hydrolase H0H25_RS10720 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H0H25_RS10730 ENOG4105CHM Aminotransferase H0H25_RS10755 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H0H25_RS10760 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) H0H25_RS10765 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) H0H25_RS10785 ENOG4108JYZ YitT family H0H25_RS10825 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) H0H25_RS10830 ENOG4108Z7F N-acetyltransferase H0H25_RS10835 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) H0H25_RS10855 ENOG4108594 Permease of the drug metabolite transporter H0H25_RS10865 ENOG4105CAY ferredoxin--nadp reductase H0H25_RS10870 ENOG41083MR nifu domain-containing protein H0H25_RS10880 ENOG4105C03 ribonuclease H0H25_RS10895 ENOG4108UUM single-stranded DNA-binding protein H0H25_RS10920 ENOG4105CJ1 ABC, transporter H0H25_RS10960 ENOG4108HRK Histidine kinase H0H25_RS10980 ENOG4105DY9 regulatoR H0H25_RS10990 ENOG4107SF2 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) H0H25_RS11000 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H0H25_RS11005 ENOG4105K64 Glycosyl transferase, family 2 H0H25_RS11015 ENOG4105C0K Gdp-mannose 4,6-dehydratase H0H25_RS11025 ENOG4105K64 Glycosyl transferase, family 2 H0H25_RS11030 ENOG410650X lipopolysaccharide core region biosynthetic process H0H25_RS11045 ENOG4105CKK Glycosyl transferase, family 2 H0H25_RS11055 ENOG4106WTF Glycosyl transferase, family 2 H0H25_RS11065 ENOG4108JMC lipopolysaccharide core biosynthesis protein H0H25_RS11075 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) H0H25_RS11085 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H0H25_RS11090 ENOG4105CRQ synthase (Component I) H0H25_RS11135 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) H0H25_RS11145 ENOG4105CTQ phosphohexokinase H0H25_RS11150 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H0H25_RS11165 ENOG4105C0P Mg chelatase subunit ChlI H0H25_RS11170 ENOG4105FR1 rard protein H0H25_RS11185 ENOG4105C9Q fumarate hydratase class II H0H25_RS11200 ENOG4105K89 arsenate reductase H0H25_RS11205 ENOG4107FCW Abortive infection protein H0H25_RS11220 ENOG4108UXE Protein tyrosine phosphatase H0H25_RS11240 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H0H25_RS11250 ENOG4105CNU cell division protein FtsK H0H25_RS11265 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) H0H25_RS11285 ENOG4105CHU acetyl-coa acetyltransferase H0H25_RS11315 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) H0H25_RS11410 ENOG4105C4R Atp-dependent dna helicase H0H25_RS11665 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) H0H25_RS11690 ENOG4105CMV Succinyl-CoA synthetase subunit beta H0H25_RS11720 ENOG4105D3R alkyl hydroperoxide reductase H0H25_RS11745 ENOG41067HZ cytochrome C, class I H0H25_RS11750 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i H0H25_RS11755 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H0H25_RS11760 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H0H25_RS11775 ENOG4107RYR Transcriptional regulator, Crp Fnr family H0H25_RS11795 ENOG4105K5B UPF0225 protein H0H25_RS11805 ENOG4105C1P efflux transporter, rnd family, mfp subunit H0H25_RS11825 ENOG4105CKK Glycosyl transferase, family 2 H0H25_RS11855 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H0H25_RS11870 ENOG4105C1J atp-dependent rna helicase H0H25_RS11890 ENOG4105CUY Mechanosensitive ion channel H0H25_RS11895 ENOG4108S4H thioesterase Superfamily protein H0H25_RS11915 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) H0H25_RS11920 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase H0H25_RS11925 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H0H25_RS11930 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H0H25_RS11935 ENOG4105CIH Imidazole acetol-phosphate transaminase H0H25_RS11940 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H0H25_RS11945 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) H0H25_RS11955 ENOG4105E0M Sulfatase H0H25_RS11965 ENOG4105CHR reductase H0H25_RS11970 ENOG4105C6E dna polymerase iii H0H25_RS12005 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H0H25_RS12015 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H25_RS12020 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) H0H25_RS12025 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H25_RS12030 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H25_RS12035 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0H25_RS12040 ENOG4105DCI Phosphohydrolase H0H25_RS12050 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) H0H25_RS12075 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) H0H25_RS12105 ENOG4107Z3H Transcriptional regulator, TetR family H0H25_RS12125 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase H0H25_RS12140 ENOG4107QXV Phosphate transporter H0H25_RS12150 ENOG4107QX3 carboxylase H0H25_RS12170 ENOG4108V1U phospholipid-binding protein H0H25_RS12205 ENOG4105CHR reductase H0H25_RS12210 ENOG4105CVP deoxyribo-dipyrimidine photolyase H0H25_RS12225 ENOG4105BZU Histidine kinase H0H25_RS12235 ENOG4105BZU Histidine kinase H0H25_RS12245 ENOG4105DY9 regulatoR H0H25_RS12270 ENOG4105CBC glutamate synthase H0H25_RS12275 ENOG4105ERH Fumarylacetoacetate hydrolase H0H25_RS12280 ENOG4105CFP Peptidase U32 H0H25_RS12285 ENOG4105CPP Dehydrogenase, E1 component H0H25_RS12305 ENOG4105D3A purine nucleoside phosphorylase DeoD-type H0H25_RS12335 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) H0H25_RS12355 ENOG4105C5H ABC transporter H0H25_RS12380 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H0H25_RS12385 ENOG4108ETT Dehydrogenase H0H25_RS12435 ENOG4105CPN adenine deaminase H0H25_RS12455 ENOG4107T8J thymidine kinase H0H25_RS12460 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H0H25_RS12465 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) H0H25_RS12470 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0H25_RS12475 ENOG4105K8N protein family UPF0079, ATPase H0H25_RS12480 ENOG4105DCF alanine dehydrogenase