locus-tag	class	description
H0H25_RS00030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H0H25_RS00035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0H25_RS00040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0H25_RS00045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0H25_RS00050	COG0612	Peptidase, M16
H0H25_RS00065	COG1012	belongs to the aldehyde dehydrogenase family
H0H25_RS00070	COG0564	pseudouridine synthase activity
H0H25_RS00075	COG0793	Belongs to the peptidase S41A family
H0H25_RS00080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H0H25_RS00085	COG1760	l-serine dehydratase
H0H25_RS00090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0H25_RS00125	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H0H25_RS00125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0H25_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0H25_RS00155	COG1770	oligopeptidase
H0H25_RS00160	COG0009	L-threonylcarbamoyladenylate synthase
H0H25_RS00185	COG0443	Heat shock 70 kDa protein
H0H25_RS00235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0H25_RS00260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0H25_RS00275	COG1611	Belongs to the LOG family
H0H25_RS00285	COG1522	sequence-specific DNA binding
H0H25_RS00315	COG2986	histidine ammonia-lyase
H0H25_RS00320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0H25_RS00330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0H25_RS00335	COG0217	transcriptional regulatory protein
H0H25_RS00340	COG1132	(ABC) transporter
H0H25_RS00360	COG0183	Belongs to the thiolase family
H0H25_RS00365	COG0791	NLP P60 protein
H0H25_RS00370	COG3011	Protein conserved in bacteria
H0H25_RS00380	COG1301	dicarboxylic acid transport
H0H25_RS00385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H0H25_RS00395	COG0583	DNA-binding transcription factor activity
H0H25_RS00400	COG0438	transferase activity, transferring glycosyl groups
H0H25_RS00420	COG1472	Belongs to the glycosyl hydrolase 3 family
H0H25_RS00430	COG2181	nitrate reductase activity
H0H25_RS00430	COG0247	lactate metabolic process
H0H25_RS00440	COG0247	lactate metabolic process
H0H25_RS00440	COG2181	nitrate reductase activity
H0H25_RS00450	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0H25_RS00460	COG0251	oxidation-reduction process
H0H25_RS00475	COG0542	response to heat
H0H25_RS00480	COG0189	ligase activity
H0H25_RS00480	COG4067	protein conserved in archaea
H0H25_RS00485	COG2323	membrane
H0H25_RS00490	COG2321	neutral zinc metallopeptidase
H0H25_RS00515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0H25_RS00540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0H25_RS00565	COG0116	Belongs to the methyltransferase superfamily
H0H25_RS00565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H0H25_RS00585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H0H25_RS00600	COG0861	Integral membrane protein TerC family
H0H25_RS00605	COG2356	endonuclease I
H0H25_RS00615	COG0022	dehydrogenase e1 component
H0H25_RS00620	COG3022	response to hydroperoxide
H0H25_RS00635	COG2197	response regulator
H0H25_RS00670	COG1104	cysteine desulfurase activity
H0H25_RS00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0H25_RS00695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0H25_RS00725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0H25_RS00725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0H25_RS00730	COG2356	endonuclease I
H0H25_RS00785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0H25_RS00795	COG3958	Transketolase
H0H25_RS00800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0H25_RS00810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H0H25_RS00855	COG1090	epimerase
H0H25_RS00860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0H25_RS00865	COG0484	heat shock protein binding
H0H25_RS00870	COG4152	abc transporter atp-binding protein
H0H25_RS00875	COG1668	transmembrane transport
H0H25_RS00880	COG2204	response regulator
H0H25_RS00900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0H25_RS00910	COG0513	Belongs to the DEAD box helicase family
H0H25_RS00920	COG2050	protein possibly involved in aromatic compounds catabolism
H0H25_RS00935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0H25_RS00945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0H25_RS00950	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0H25_RS00960	COG0564	pseudouridine synthase activity
H0H25_RS00965	COG2234	aminopeptidase activity
H0H25_RS00990	COG4771	TonB-dependent receptor
H0H25_RS01005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0H25_RS01015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H0H25_RS01020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0H25_RS01045	COG0302	gtp cyclohydrolase
H0H25_RS01050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0H25_RS01055	COG1136	(ABC) transporter
H0H25_RS01065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0H25_RS01070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0H25_RS01095	COG3158	transport of potassium into the cell
H0H25_RS01100	COG3781	membrane
H0H25_RS01115	COG0492	ferredoxin-NADP+ reductase activity
H0H25_RS01120	COG0305	Participates in initiation and elongation during chromosome replication
H0H25_RS01125	COG0825	malonyl-CoA metabolic process
H0H25_RS01140	COG0343	queuine tRNA-ribosyltransferase activity
H0H25_RS01160	COG0688	phosphatidylethanolamine metabolic process
H0H25_RS01165	COG4589	Belongs to the CDS family
H0H25_RS01175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0H25_RS01180	COG0799	negative regulation of ribosome biogenesis
H0H25_RS01185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H0H25_RS01185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H0H25_RS01190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H0H25_RS01195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0H25_RS01200	COG0215	cysteine-tRNA ligase activity
H0H25_RS01205	COG0302	gtp cyclohydrolase
H0H25_RS01235	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H25_RS01245	COG0488	(ABC) transporter
H0H25_RS01265	COG1136	(ABC) transporter
H0H25_RS01280	COG0653	protein targeting
H0H25_RS01290	COG1858	cytochrome C peroxidase
H0H25_RS01310	COG0277	FAD linked oxidase domain protein
H0H25_RS01315	COG2223	nitrite transmembrane transporter activity
H0H25_RS01335	COG0534	Mate efflux family protein
H0H25_RS01340	COG1858	cytochrome C peroxidase
H0H25_RS01350	COG2326	polyphosphate kinase activity
H0H25_RS01370	COG0514	ATP-dependent DNA helicase (RecQ)
H0H25_RS01385	COG0488	(ABC) transporter
H0H25_RS01440	COG2304	oxidoreductase activity
H0H25_RS01445	COG4771	TonB-dependent receptor
H0H25_RS01470	COG0848	biopolymer transport protein
H0H25_RS01480	COG0285	dihydrofolate synthase activity
H0H25_RS01495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H0H25_RS01500	COG0284	orotidine-5'-phosphate decarboxylase activity
H0H25_RS01505	COG1862	Preprotein translocase
H0H25_RS01515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0H25_RS01525	COG1132	(ABC) transporter
H0H25_RS01535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0H25_RS01540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0H25_RS01550	COG0187	DNA topoisomerase II activity
H0H25_RS01555	COG0367	asparagine synthase
H0H25_RS01565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0H25_RS01575	COG4771	TonB-dependent receptor
H0H25_RS01590	COG2884	Cell division ATP-binding protein ftsE
H0H25_RS01600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0H25_RS01610	COG0778	Nitroreductase
H0H25_RS01620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0H25_RS01625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0H25_RS01625	COG0512	Glutamine amidotransferase of anthranilate synthase
H0H25_RS01630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0H25_RS01635	COG0134	indole-3-glycerol-phosphate synthase activity
H0H25_RS01640	COG0135	phosphoribosylanthranilate isomerase activity
H0H25_RS01645	COG0133	tryptophan synthase activity
H0H25_RS01650	COG0159	tryptophan synthase activity
H0H25_RS01660	COG1309	transcriptional regulator
H0H25_RS01680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H0H25_RS01705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0H25_RS01810	COG1575	Belongs to the MenA family. Type 1 subfamily
H0H25_RS01820	COG2996	Protein conserved in bacteria
H0H25_RS01855	COG0268	Binds directly to 16S ribosomal RNA
H0H25_RS01870	COG0442	prolyl-tRNA aminoacylation
H0H25_RS01885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0H25_RS01920	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H0H25_RS01925	COG0105	UTP biosynthetic process
H0H25_RS01935	COG1696	Membrane protein involved in D-alanine export
H0H25_RS01970	COG0386	Belongs to the glutathione peroxidase family
H0H25_RS01975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0H25_RS01975	COG1333	cytochrome c biogenesis protein
H0H25_RS01995	COG0424	maF-like protein
H0H25_RS02000	COG0101	tRNA pseudouridine synthase activity
H0H25_RS02005	COG1132	(ABC) transporter
H0H25_RS02010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0H25_RS02025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0H25_RS02030	COG0149	triose-phosphate isomerase activity
H0H25_RS02035	COG0552	protein localization to endoplasmic reticulum
H0H25_RS02045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H0H25_RS02050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0H25_RS02055	COG1058	Belongs to the CinA family
H0H25_RS02055	COG1546	Belongs to the CinA family
H0H25_RS02070	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0H25_RS02075	COG2176	DNA-directed DNA polymerase activity
H0H25_RS02075	COG5002	protein histidine kinase activity
H0H25_RS02085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0H25_RS02090	COG0500	methyltransferase
H0H25_RS02095	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H0H25_RS02100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0H25_RS02170	COG4206	TonB-dependent receptor
H0H25_RS02185	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0H25_RS02190	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
H0H25_RS02205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0H25_RS02225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0H25_RS02245	COG1663	tetraacyldisaccharide 4'-kinase activity
H0H25_RS02255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0H25_RS02260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0H25_RS02340	COG1366	Belongs to the anti-sigma-factor antagonist family
H0H25_RS02340	COG2202	Pas domain
H0H25_RS02360	COG4771	TonB-dependent receptor
H0H25_RS02375	COG0018	arginyl-trna synthetase
H0H25_RS02390	COG3328	transposase activity
H0H25_RS02395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0H25_RS02410	COG3842	ATPase activity
H0H25_RS02425	COG2885	chlorophyll binding
H0H25_RS02435	COG0326	Molecular chaperone. Has ATPase activity
H0H25_RS02470	COG3279	Response regulator of the LytR AlgR family
H0H25_RS02505	COG1363	Peptidase, m42
H0H25_RS02510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0H25_RS02520	COG1702	phosphate starvation-inducible protein PhoH
H0H25_RS02575	COG0592	DNA-directed DNA polymerase activity
H0H25_RS02580	COG0513	Belongs to the DEAD box helicase family
H0H25_RS02590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0H25_RS02610	COG1234	tRNA 3'-trailer cleavage
H0H25_RS02620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0H25_RS02625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0H25_RS02650	COG1595	DNA-templated transcription, initiation
H0H25_RS02655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0H25_RS02665	COG1446	asparaginase
H0H25_RS02670	COG4242	Belongs to the peptidase S51 family
H0H25_RS02680	COG0823	Involved in the tonB-independent uptake of proteins
H0H25_RS02680	COG1506	peptidase
H0H25_RS02720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0H25_RS02720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0H25_RS02730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0H25_RS02730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0H25_RS02745	COG0681	Belongs to the peptidase S26 family
H0H25_RS02750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0H25_RS02760	COG1475	DNA binding
H0H25_RS02765	COG1192	Involved in chromosome partitioning
H0H25_RS02770	COG1028	Short-chain dehydrogenase reductase Sdr
H0H25_RS02775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0H25_RS02785	COG0254	rRNA binding
H0H25_RS02795	COG0463	Glycosyl transferase, family 2
H0H25_RS02800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0H25_RS02805	COG1132	(ABC) transporter
H0H25_RS02825	COG0739	heme binding
H0H25_RS02845	COG1418	mRNA catabolic process
H0H25_RS02850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0H25_RS02880	COG2217	Heavy metal translocating P-type atpase
H0H25_RS02895	COG3278	Belongs to the heme-copper respiratory oxidase family
H0H25_RS02910	COG0348	domain, Protein
H0H25_RS02930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0H25_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
H0H25_RS02945	COG0714	Associated with various cellular activities
H0H25_RS02950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0H25_RS02955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0H25_RS02960	COG2885	chlorophyll binding
H0H25_RS02990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0H25_RS03005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0H25_RS03010	COG0085	RNA polymerase activity
H0H25_RS03015	COG0222	ribosome binding
H0H25_RS03020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0H25_RS03025	COG0081	regulation of translation
H0H25_RS03030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0H25_RS03050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0H25_RS03075	COG4974	Belongs to the 'phage' integrase family
H0H25_RS03080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H0H25_RS03085	COG1960	acyl-CoA dehydrogenase activity
H0H25_RS03100	COG0470	DNA polymerase III
H0H25_RS03105	COG2176	DNA-directed DNA polymerase activity
H0H25_RS03125	COG4771	TonB-dependent receptor
H0H25_RS03130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0H25_RS03135	COG0321	lipoyl(octanoyl) transferase activity
H0H25_RS03140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0H25_RS03150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0H25_RS03155	COG0791	NLP P60 protein
H0H25_RS03155	COG1388	LysM domain
H0H25_RS03160	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0H25_RS03165	COG0824	Thioesterase
H0H25_RS03170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0H25_RS03180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0H25_RS03195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0H25_RS03205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0H25_RS03210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0H25_RS03220	COG0791	NLP P60 protein
H0H25_RS03225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0H25_RS03240	COG1187	pseudouridine synthase activity
H0H25_RS03245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0H25_RS03260	COG4680	protein conserved in bacteria
H0H25_RS03270	COG0668	transmembrane transport
H0H25_RS03275	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H0H25_RS03295	COG0514	ATP-dependent DNA helicase (RecQ)
H0H25_RS03300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0H25_RS03300	COG0517	IMP dehydrogenase activity
H0H25_RS03305	COG0805	protein transport
H0H25_RS03315	COG1137	ATPase activity
H0H25_RS03350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0H25_RS03370	COG1045	serine acetyltransferase
H0H25_RS03385	COG1216	Glycosyl transferase, family 2
H0H25_RS03395	COG1045	serine acetyltransferase
H0H25_RS03410	COG2089	acid synthase
H0H25_RS03415	COG1083	cytidylyl-transferase
H0H25_RS03435	COG1216	Glycosyl transferase, family 2
H0H25_RS03435	COG1442	glycosyl transferase family 8
H0H25_RS03440	COG0438	transferase activity, transferring glycosyl groups
H0H25_RS03450	COG1216	Glycosyl transferase, family 2
H0H25_RS03455	COG1216	Glycosyl transferase, family 2
H0H25_RS03495	COG4464	protein tyrosine phosphatase activity
H0H25_RS03500	COG0489	protein tyrosine kinase activity
H0H25_RS03515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0H25_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
H0H25_RS03540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0H25_RS03545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0H25_RS03550	COG0297	glycogen (starch) synthase activity
H0H25_RS03570	COG1086	Polysaccharide biosynthesis protein
H0H25_RS03595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H0H25_RS03605	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H0H25_RS03610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0H25_RS03620	COG0489	protein tyrosine kinase activity
H0H25_RS03630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0H25_RS03635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0H25_RS03645	COG2095	MarC family integral membrane protein
H0H25_RS03670	COG0148	phosphopyruvate hydratase activity
H0H25_RS03675	COG2312	Erythromycin esterase
H0H25_RS03680	COG0505	Belongs to the CarA family
H0H25_RS03685	COG0203	ribosomal protein L17
H0H25_RS03690	COG0202	RNA polymerase activity
H0H25_RS03695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0H25_RS03700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H0H25_RS03705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0H25_RS03710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0H25_RS03715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0H25_RS03720	COG0201	protein transport
H0H25_RS03725	COG0200	Binds to the 23S rRNA
H0H25_RS03730	COG1841	ribosomal large subunit assembly
H0H25_RS03735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0H25_RS03740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0H25_RS03745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0H25_RS03750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0H25_RS03755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0H25_RS03760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0H25_RS03765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0H25_RS03770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0H25_RS03775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H0H25_RS03780	COG0255	Belongs to the universal ribosomal protein uL29 family
H0H25_RS03785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0H25_RS03790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0H25_RS03795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0H25_RS03800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0H25_RS03805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0H25_RS03810	COG0089	rRNA binding
H0H25_RS03815	COG0088	Forms part of the polypeptide exit tunnel
H0H25_RS03820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0H25_RS03825	COG0051	transcription antitermination factor activity, RNA binding
H0H25_RS03830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H0H25_RS03835	COG0049	tRNA binding
H0H25_RS03840	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0H25_RS03860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0H25_RS03870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0H25_RS03885	COG2003	Belongs to the UPF0758 family
H0H25_RS03890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0H25_RS03900	COG3591	Belongs to the peptidase S1B family
H0H25_RS03905	COG1652	LysM domain
H0H25_RS03910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H0H25_RS03915	COG1253	flavin adenine dinucleotide binding
H0H25_RS03920	COG0563	adenylate kinase activity
H0H25_RS03935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0H25_RS03940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0H25_RS03980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0H25_RS03980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0H25_RS04000	COG1442	glycosyl transferase family 8
H0H25_RS04000	COG1216	Glycosyl transferase, family 2
H0H25_RS04005	COG1215	transferase activity, transferring glycosyl groups
H0H25_RS04010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0H25_RS04015	COG1127	ABC transporter
H0H25_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
H0H25_RS04045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0H25_RS04050	COG0295	cytidine deaminase activity
H0H25_RS04070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0H25_RS04115	COG3876	Protein conserved in bacteria
H0H25_RS04135	COG0602	queuosine metabolic process
H0H25_RS04195	COG0433	COG0433 Predicted ATPase
H0H25_RS04200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0H25_RS04210	COG0010	Belongs to the arginase family
H0H25_RS04215	COG3844	kynureninase activity
H0H25_RS04225	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0H25_RS04230	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0H25_RS04235	COG1007	ATP synthesis coupled electron transport
H0H25_RS04240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0H25_RS04250	COG0713	ATP synthesis coupled electron transport
H0H25_RS04255	COG0839	Belongs to the complex I subunit 6 family
H0H25_RS04260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0H25_RS04265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H0H25_RS04270	COG1034	ATP synthesis coupled electron transport
H0H25_RS04285	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H0H25_RS04290	COG0649	NAD binding
H0H25_RS04295	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0H25_RS04300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0H25_RS04305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0H25_RS04315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0H25_RS04350	COG0481	GTPase activity
H0H25_RS04365	COG3328	transposase activity
H0H25_RS04370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0H25_RS04385	COG0720	synthase
H0H25_RS04390	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H0H25_RS04395	COG0017	Asparaginyl-tRNA synthetase
H0H25_RS04410	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H0H25_RS04440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0H25_RS04470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0H25_RS04480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0H25_RS04505	COG1131	(ABC) transporter
H0H25_RS04540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0H25_RS04550	COG1233	COG1233 Phytoene dehydrogenase and related
H0H25_RS04565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0H25_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
H0H25_RS04590	COG0084	hydrolase, TatD family'
H0H25_RS04600	COG0252	asparaginase activity
H0H25_RS04660	COG4968	Prepilin-type N-terminal cleavage methylation domain
H0H25_RS04695	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H0H25_RS04775	COG1012	belongs to the aldehyde dehydrogenase family
H0H25_RS04780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0H25_RS04790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0H25_RS04795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H0H25_RS04800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0H25_RS04810	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0H25_RS04815	COG0793	Belongs to the peptidase S41A family
H0H25_RS04820	COG0658	competence protein
H0H25_RS04820	COG2333	competence protein COMEC
H0H25_RS04825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0H25_RS04835	COG3104	oligopeptide transport
H0H25_RS04840	COG3104	oligopeptide transport
H0H25_RS04890	COG0793	Belongs to the peptidase S41A family
H0H25_RS04900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0H25_RS04910	COG3852	Histidine kinase
H0H25_RS04915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0H25_RS04925	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0H25_RS04935	COG0519	Catalyzes the synthesis of GMP from XMP
H0H25_RS04950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0H25_RS04955	COG1968	undecaprenyl-diphosphatase activity
H0H25_RS04965	COG2177	Part of the ABC transporter FtsEX involved in
H0H25_RS04975	COG0671	phosphoesterase, PA-phosphatase related
H0H25_RS04980	COG0495	leucyl-tRNA aminoacylation
H0H25_RS04995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0H25_RS05005	COG1506	peptidase
H0H25_RS05005	COG0823	Involved in the tonB-independent uptake of proteins
H0H25_RS05020	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0H25_RS05025	COG1522	sequence-specific DNA binding
H0H25_RS05035	COG2363	Small membrane protein
H0H25_RS05040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H0H25_RS05045	COG0594	ribonuclease P activity
H0H25_RS05050	COG0439	Biotin carboxylase
H0H25_RS05055	COG0511	ligase activity, forming carbon-carbon bonds
H0H25_RS05060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0H25_RS05065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0H25_RS05075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0H25_RS05080	COG0307	riboflavin synthase, alpha
H0H25_RS05095	COG2151	metal-sulfur cluster biosynthetic enzyme
H0H25_RS05100	COG2166	iron-sulfur cluster assembly
H0H25_RS05110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0H25_RS05120	COG0719	Fe-S assembly protein
H0H25_RS05125	COG0396	ATPase activity
H0H25_RS05130	COG0719	Fe-S assembly protein
H0H25_RS05135	COG0316	Belongs to the HesB IscA family
H0H25_RS05140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0H25_RS05160	COG0633	Ferredoxin
H0H25_RS05205	COG0567	Dehydrogenase, E1 component
H0H25_RS05235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0H25_RS05245	COG0138	bifunctional purine biosynthesis protein purh
H0H25_RS05250	COG1077	Cell shape determining protein MreB Mrl
H0H25_RS05265	COG0768	penicillin binding
H0H25_RS05270	COG0772	Belongs to the SEDS family
H0H25_RS05315	COG0423	glycine-tRNA ligase activity
H0H25_RS05320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0H25_RS05340	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H0H25_RS05360	COG0758	DNA mediated transformation
H0H25_RS05370	COG1607	acyl-coa hydrolase
H0H25_RS05405	COG4115	mRNA cleavage
H0H25_RS05410	COG2161	toxin-antitoxin pair type II binding
H0H25_RS05420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0H25_RS05425	COG0756	dUTP diphosphatase activity
H0H25_RS05450	COG4264	IucA IucC family
H0H25_RS05455	COG2918	glutathione biosynthetic process
H0H25_RS05455	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0H25_RS05465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0H25_RS05470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H0H25_RS05475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0H25_RS05480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0H25_RS05485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0H25_RS05490	COG0356	it plays a direct role in the translocation of protons across the membrane
H0H25_RS05525	COG0859	PFAM glycosyl transferase family 9
H0H25_RS05535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H0H25_RS05550	COG0151	Belongs to the GarS family
H0H25_RS05560	COG1215	transferase activity, transferring glycosyl groups
H0H25_RS05570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0H25_RS05605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0H25_RS05610	COG2183	response to ionizing radiation
H0H25_RS05635	COG0557	exoribonuclease II activity
H0H25_RS05685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0H25_RS05695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0H25_RS05700	COG0445	tRNA wobble uridine modification
H0H25_RS05705	COG2226	methyltransferase
H0H25_RS05740	COG0470	DNA polymerase III
H0H25_RS05775	COG0126	phosphoglycerate kinase activity
H0H25_RS05780	COG1388	LysM domain
H0H25_RS05780	COG0791	NLP P60 protein
H0H25_RS05785	COG2153	protein acetylation
H0H25_RS05800	COG1774	PSP1 C-terminal conserved region
H0H25_RS05810	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0H25_RS05815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0H25_RS05820	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H0H25_RS05840	COG0700	Nucleoside recognition
H0H25_RS05860	COG0113	porphobilinogen synthase activity
H0H25_RS05870	COG0408	coproporphyrinogen oxidase activity
H0H25_RS05890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H0H25_RS05900	COG0181	hydroxymethylbilane synthase activity
H0H25_RS05905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0H25_RS05915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0H25_RS05925	COG5000	phosphorelay sensor kinase activity
H0H25_RS05930	COG1024	Enoyl-CoA hydratase
H0H25_RS05935	COG1418	mRNA catabolic process
H0H25_RS05960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0H25_RS05960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0H25_RS05975	COG1619	proteins homologs of microcin C7 resistance protein MccF
H0H25_RS05980	COG0792	nuclease activity
H0H25_RS05985	COG0667	Aldo Keto reductase
H0H25_RS05990	COG1360	Flagellar Motor Protein
H0H25_RS05995	COG0708	Exodeoxyribonuclease III
H0H25_RS06005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0H25_RS06020	COG2239	Acts as a magnesium transporter
H0H25_RS06025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0H25_RS06045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0H25_RS06065	COG1914	H( )-stimulated, divalent metal cation uptake system
H0H25_RS06100	COG0629	single-stranded DNA binding
H0H25_RS06115	COG3590	peptidase
H0H25_RS06125	COG1999	signal sequence binding
H0H25_RS06145	COG1053	succinate dehydrogenase
H0H25_RS06155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0H25_RS06170	COG4771	TonB-dependent receptor
H0H25_RS06175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0H25_RS06195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0H25_RS06210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H0H25_RS06220	COG0297	glycogen (starch) synthase activity
H0H25_RS06230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0H25_RS06245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0H25_RS06260	COG0156	8-amino-7-oxononanoate synthase activity
H0H25_RS06285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0H25_RS06340	COG0714	Associated with various cellular activities
H0H25_RS06360	COG2824	Alkylphosphonate utilization operon protein PhnA
H0H25_RS06365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0H25_RS06370	COG1979	alcohol dehydrogenase
H0H25_RS06375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H0H25_RS06385	COG0166	Belongs to the GPI family
H0H25_RS06390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0H25_RS06425	COG0006	proline dipeptidase activity
H0H25_RS06445	COG0156	8-amino-7-oxononanoate synthase activity
H0H25_RS06455	COG1074	ATP-dependent DNA helicase activity
H0H25_RS06465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0H25_RS06480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0H25_RS06485	COG0463	Glycosyl transferase, family 2
H0H25_RS06610	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H0H25_RS06620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0H25_RS06630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0H25_RS06635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0H25_RS06645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0H25_RS06650	COG2954	triphosphatase activity
H0H25_RS06665	COG0328	RNA-DNA hybrid ribonuclease activity
H0H25_RS06670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0H25_RS06675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0H25_RS06680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0H25_RS06685	COG0571	ribonuclease III activity
H0H25_RS06695	COG0469	pyruvate kinase activity
H0H25_RS06715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0H25_RS06720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H0H25_RS06770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0H25_RS06775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0H25_RS06785	COG0322	excinuclease ABC activity
H0H25_RS06790	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0H25_RS06795	COG0531	amino acid
H0H25_RS06800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H0H25_RS06805	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H0H25_RS06815	COG3483	tryptophan 2,3-dioxygenase activity
H0H25_RS06825	COG0193	aminoacyl-tRNA hydrolase activity
H0H25_RS06830	COG1404	Belongs to the peptidase S8 family
H0H25_RS06830	COG4935	Belongs to the peptidase S8 family
H0H25_RS06835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0H25_RS06840	COG0196	riboflavin kinase activity
H0H25_RS06845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0H25_RS06860	COG0346	lactoylglutathione lyase activity
H0H25_RS06865	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0H25_RS06875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0H25_RS06900	COG3645	SOS response
H0H25_RS06910	COG1490	D-aminoacyl-tRNA deacylase activity
H0H25_RS06915	COG1162	GTPase activity
H0H25_RS06920	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H0H25_RS06925	COG0436	Aminotransferase
H0H25_RS06950	COG0527	aspartate kinase activity
H0H25_RS06950	COG0460	homoserine dehydrogenase
H0H25_RS06955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0H25_RS06975	COG3118	belongs to the thioredoxin family
H0H25_RS06985	COG1428	Deoxynucleoside kinase
H0H25_RS07025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0H25_RS07030	COG1381	Involved in DNA repair and RecF pathway recombination
H0H25_RS07040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0H25_RS07060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0H25_RS07065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0H25_RS07070	COG1278	Cold shock
H0H25_RS07075	COG0590	tRNA wobble adenosine to inosine editing
H0H25_RS07085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0H25_RS07100	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H0H25_RS07140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0H25_RS07140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0H25_RS07185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H0H25_RS07190	COG0501	Belongs to the peptidase M48B family
H0H25_RS07200	COG0527	aspartate kinase activity
H0H25_RS07225	COG2081	HI0933 family
H0H25_RS07230	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H0H25_RS07250	COG1187	pseudouridine synthase activity
H0H25_RS07280	COG2885	chlorophyll binding
H0H25_RS07285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0H25_RS07310	COG2226	methyltransferase
H0H25_RS07315	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0H25_RS07340	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H0H25_RS07350	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H0H25_RS07355	COG2086	electron transfer activity
H0H25_RS07360	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H25_RS07360	COG0022	dehydrogenase e1 component
H0H25_RS07370	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0H25_RS07400	COG0228	four-way junction DNA binding
H0H25_RS07405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0H25_RS07410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H0H25_RS07415	COG1960	acyl-CoA dehydrogenase activity
H0H25_RS07420	COG0194	GDP metabolic process
H0H25_RS07450	COG0626	cystathionine gamma-synthase activity
H0H25_RS07470	COG0745	RESPONSE REGULATOR receiver
H0H25_RS07475	COG5002	protein histidine kinase activity
H0H25_RS07495	COG0581	inorganic phosphate transmembrane transporter activity
H0H25_RS07500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0H25_RS07505	COG0704	Plays a role in the regulation of phosphate uptake
H0H25_RS07510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0H25_RS07520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0H25_RS07545	COG0437	4 iron, 4 sulfur cluster binding
H0H25_RS07570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0H25_RS07575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0H25_RS07590	COG4717	serine-type aminopeptidase activity
H0H25_RS07630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0H25_RS07635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0H25_RS07660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0H25_RS07670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0H25_RS07675	COG1428	Deoxynucleoside kinase
H0H25_RS07680	COG0616	signal peptide processing
H0H25_RS07695	COG0860	N-Acetylmuramoyl-L-alanine amidase
H0H25_RS07705	COG1519	Transferase
H0H25_RS07705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0H25_RS07715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0H25_RS07725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0H25_RS07740	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H0H25_RS07745	COG0436	Aminotransferase
H0H25_RS07750	COG3239	Fatty acid desaturase
H0H25_RS07755	COG0357	Ribosomal RNA small subunit methyltransferase G
H0H25_RS07760	COG1012	belongs to the aldehyde dehydrogenase family
H0H25_RS07770	COG2967	ApaG domain
H0H25_RS07800	COG2274	protein secretion by the type I secretion system
H0H25_RS07810	COG0427	acetyl-CoA hydrolase
H0H25_RS07820	COG2217	Heavy metal translocating P-type atpase
H0H25_RS07840	COG0351	phosphomethylpyrimidine kinase
H0H25_RS07845	COG0352	thiamine-phosphate diphosphorylase activity
H0H25_RS07850	COG2022	thiamine diphosphate biosynthetic process
H0H25_RS07860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0H25_RS07865	COG0528	UMP kinase activity
H0H25_RS07870	COG0233	cytoplasmic translational termination
H0H25_RS07900	COG0475	glutathione-regulated potassium exporter activity
H0H25_RS07920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0H25_RS07925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0H25_RS07930	COG0440	acetolactate synthase activity
H0H25_RS07935	COG0028	Belongs to the TPP enzyme family
H0H25_RS07940	COG0129	dihydroxy-acid dehydratase activity
H0H25_RS07955	COG3328	transposase activity
H0H25_RS07965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0H25_RS07970	COG0052	Belongs to the universal ribosomal protein uS2 family
H0H25_RS07975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0H25_RS07980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0H25_RS07985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0H25_RS07985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0H25_RS08000	COG2095	MarC family integral membrane protein
H0H25_RS08015	COG0793	Belongs to the peptidase S41A family
H0H25_RS08035	COG0589	response to stress
H0H25_RS08040	COG0779	Required for maturation of 30S ribosomal subunits
H0H25_RS08045	COG0195	Participates in both transcription termination and antitermination
H0H25_RS08045	COG2251	uridine kinase activity
H0H25_RS08050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0H25_RS08160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0H25_RS08180	COG3328	transposase activity
H0H25_RS08190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H0H25_RS08250	COG1196	nuclear chromosome segregation
H0H25_RS08320	COG3328	transposase activity
H0H25_RS08375	COG3328	transposase activity
H0H25_RS08490	COG4974	Belongs to the 'phage' integrase family
H0H25_RS08495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0H25_RS08505	COG2989	Protein conserved in bacteria
H0H25_RS08515	COG0456	acetyltransferase
H0H25_RS08525	COG3340	Belongs to the peptidase S51 family
H0H25_RS08545	COG0531	amino acid
H0H25_RS08550	COG2255	four-way junction helicase activity
H0H25_RS08555	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0H25_RS08560	COG0280	phosphate acetyltransferase
H0H25_RS08560	COG0281	malic enzyme
H0H25_RS08565	COG0632	four-way junction helicase activity
H0H25_RS08580	COG0509	glycine decarboxylation via glycine cleavage system
H0H25_RS08590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H0H25_RS08600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0H25_RS08620	COG2322	membrane
H0H25_RS08625	COG1999	signal sequence binding
H0H25_RS08650	COG0109	protoheme IX farnesyltransferase activity
H0H25_RS08655	COG1214	PFAM Peptidase M22, glycoprotease
H0H25_RS08665	COG1331	Highly conserved protein containing a thioredoxin domain
H0H25_RS08680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0H25_RS08685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0H25_RS08715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0H25_RS08725	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0H25_RS08730	COG1131	(ABC) transporter
H0H25_RS08745	COG1950	PFAM Membrane protein of
H0H25_RS08750	COG0544	peptidyl-prolyl cis-trans isomerase activity
H0H25_RS08760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0H25_RS08765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0H25_RS08770	COG0671	phosphoesterase, PA-phosphatase related
H0H25_RS08780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H0H25_RS08820	COG0358	DNA primase activity
H0H25_RS08830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0H25_RS08845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H0H25_RS08855	COG2001	Belongs to the MraZ family
H0H25_RS08860	COG0275	rRNA processing
H0H25_RS08870	COG0768	penicillin binding
H0H25_RS08875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0H25_RS08880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0H25_RS08890	COG0772	Belongs to the SEDS family
H0H25_RS08895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0H25_RS08900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0H25_RS08915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0H25_RS08920	COG1610	YqeY-like protein
H0H25_RS08935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0H25_RS08940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0H25_RS08950	COG1185	polyribonucleotide nucleotidyltransferase activity
H0H25_RS08955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0H25_RS08960	COG0702	epimerase
H0H25_RS08965	COG0415	Belongs to the DNA photolyase family
H0H25_RS08970	COG3046	protein related to deoxyribodipyrimidine photolyase
H0H25_RS08980	COG0415	Belongs to the DNA photolyase family
H0H25_RS09000	COG1956	GAF domain-containing protein
H0H25_RS09040	COG0288	reversible hydration of carbon dioxide
H0H25_RS09050	COG1739	Uncharacterized protein family UPF0029
H0H25_RS09060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0H25_RS09060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0H25_RS09070	COG2890	protein-(glutamine-N5) methyltransferase activity
H0H25_RS09080	COG0124	histidyl-tRNA synthetase
H0H25_RS09085	COG4974	Belongs to the 'phage' integrase family
H0H25_RS09095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H0H25_RS09115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0H25_RS09135	COG0514	ATP-dependent DNA helicase (RecQ)
H0H25_RS09140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0H25_RS09150	COG1678	Uncharacterized ACR, COG1678
H0H25_RS09170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0H25_RS09180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0H25_RS09185	COG3118	belongs to the thioredoxin family
H0H25_RS09200	COG0367	asparagine synthase
H0H25_RS09205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0H25_RS09210	COG1120	ATPase activity
H0H25_RS09215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0H25_RS09220	COG1187	pseudouridine synthase activity
H0H25_RS09235	COG1607	acyl-coa hydrolase
H0H25_RS09250	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H0H25_RS09260	COG0459	protein refolding
H0H25_RS09270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0H25_RS09290	COG2204	response regulator
H0H25_RS09295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0H25_RS09330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0H25_RS09380	COG0488	(ABC) transporter
H0H25_RS09405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0H25_RS09410	COG1160	GTP binding
H0H25_RS09435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H0H25_RS09475	COG1132	(ABC) transporter
H0H25_RS09490	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0H25_RS09500	COG1704	LemA family
H0H25_RS09510	COG4942	peptidase
H0H25_RS09515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0H25_RS09520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0H25_RS09520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0H25_RS09520	COG1703	isobutyryl-CoA mutase activity
H0H25_RS09575	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0H25_RS09580	COG1960	acyl-CoA dehydrogenase activity
H0H25_RS09585	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0H25_RS09615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0H25_RS09625	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0H25_RS09635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H0H25_RS09660	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0H25_RS09665	COG0673	inositol 2-dehydrogenase activity
H0H25_RS09670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0H25_RS09675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0H25_RS09685	COG1696	Membrane protein involved in D-alanine export
H0H25_RS09705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0H25_RS09715	COG0706	membrane insertase activity
H0H25_RS09720	COG0504	CTP synthase activity
H0H25_RS09725	COG3530	Putative quorum-sensing-regulated virulence factor
H0H25_RS09745	COG0519	Catalyzes the synthesis of GMP from XMP
H0H25_RS09745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0H25_RS09750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0H25_RS09760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0H25_RS09765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0H25_RS09785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0H25_RS09790	COG4628	conserved protein (DUF2132)
H0H25_RS09795	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0H25_RS09800	COG0339	signal peptide processing
H0H25_RS09845	COG0336	Belongs to the RNA methyltransferase TrmD family
H0H25_RS09850	COG0335	large ribosomal subunit rRNA binding
H0H25_RS09855	COG0538	isocitrate dehydrogenase activity
H0H25_RS09875	COG2860	membrane
H0H25_RS09880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0H25_RS09885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0H25_RS09905	COG0463	Glycosyl transferase, family 2
H0H25_RS09905	COG1216	Glycosyl transferase, family 2
H0H25_RS09910	COG0463	Glycosyl transferase, family 2
H0H25_RS09915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H0H25_RS09930	COG1017	nitric oxide dioxygenase activity
H0H25_RS09930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0H25_RS09940	COG1295	ribonuclease BN
H0H25_RS09950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0H25_RS09955	COG3279	Response regulator of the LytR AlgR family
H0H25_RS09960	COG0360	Binds together with S18 to 16S ribosomal RNA
H0H25_RS09965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H0H25_RS09970	COG0359	binds to the 23S rRNA
H0H25_RS09980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0H25_RS10000	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0H25_RS10005	COG0497	DNA recombination
H0H25_RS10030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0H25_RS10045	COG0737	Belongs to the 5'-nucleotidase family
H0H25_RS10080	COG3118	belongs to the thioredoxin family
H0H25_RS10095	COG0167	dihydroorotate dehydrogenase activity
H0H25_RS10110	COG0517	IMP dehydrogenase activity
H0H25_RS10110	COG0516	GMP reductase activity
H0H25_RS10115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0H25_RS10135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0H25_RS10135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0H25_RS10150	COG0492	ferredoxin-NADP+ reductase activity
H0H25_RS10150	COG3118	belongs to the thioredoxin family
H0H25_RS10180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0H25_RS10185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0H25_RS10195	COG0156	8-amino-7-oxononanoate synthase activity
H0H25_RS10220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0H25_RS10230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H0H25_RS10235	COG0540	Belongs to the ATCase OTCase family
H0H25_RS10245	COG0539	negative regulation of cytoplasmic translation
H0H25_RS10250	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H0H25_RS10260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0H25_RS10265	COG1482	cell wall glycoprotein biosynthetic process
H0H25_RS10285	COG4774	siderophore transport
H0H25_RS10310	COG1228	amidohydrolase
H0H25_RS10315	COG0598	Magnesium transport protein CorA
H0H25_RS10340	COG0482	sulfurtransferase activity
H0H25_RS10345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0H25_RS10350	COG0038	chloride channel
H0H25_RS10360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0H25_RS10370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0H25_RS10375	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H0H25_RS10390	COG0542	response to heat
H0H25_RS10395	COG0488	(ABC) transporter
H0H25_RS10400	COG1404	Belongs to the peptidase S8 family
H0H25_RS10410	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
H0H25_RS10435	COG3956	TIGRFAM MazG family protein
H0H25_RS10445	COG0242	peptide deformylase activity
H0H25_RS10450	COG0579	oxidoreductase
H0H25_RS10455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0H25_RS10485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0H25_RS10510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H0H25_RS10510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0H25_RS10530	COG2032	superoxide dismutase activity
H0H25_RS10535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0H25_RS10545	COG0626	cystathionine gamma-synthase activity
H0H25_RS10550	COG0531	amino acid
H0H25_RS10560	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H0H25_RS10565	COG0450	alkyl hydroperoxide reductase
H0H25_RS10580	COG1960	acyl-CoA dehydrogenase activity
H0H25_RS10585	COG0183	Belongs to the thiolase family
H0H25_RS10595	COG1024	Enoyl-CoA hydratase
H0H25_RS10595	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0H25_RS10600	COG1846	Transcriptional regulator
H0H25_RS10605	COG0405	Gamma-glutamyltransferase
H0H25_RS10610	COG1022	Amp-dependent synthetase and ligase
H0H25_RS10615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0H25_RS10620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0H25_RS10635	COG2270	Major facilitator Superfamily
H0H25_RS10640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H0H25_RS10650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0H25_RS10655	COG2211	Major facilitator Superfamily
H0H25_RS10675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0H25_RS10685	COG1234	tRNA 3'-trailer cleavage
H0H25_RS10700	COG1704	LemA family
H0H25_RS10705	COG0513	Belongs to the DEAD box helicase family
H0H25_RS10710	COG0010	Belongs to the arginase family
H0H25_RS10720	COG0525	valine-tRNA ligase activity
H0H25_RS10730	COG0436	Aminotransferase
H0H25_RS10755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H0H25_RS10760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0H25_RS10765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H0H25_RS10775	COG2205	protein histidine kinase activity
H0H25_RS10785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H0H25_RS10825	COG2264	protein methyltransferase activity
H0H25_RS10830	COG1247	-acetyltransferase
H0H25_RS10835	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H0H25_RS10855	COG0697	spore germination
H0H25_RS10865	COG0492	ferredoxin-NADP+ reductase activity
H0H25_RS10870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H0H25_RS10875	COG0489	protein tyrosine kinase activity
H0H25_RS10880	COG1530	ribonuclease E activity
H0H25_RS10920	COG1131	(ABC) transporter
H0H25_RS10960	COG3275	phosphorelay sensor kinase activity
H0H25_RS10980	COG3279	Response regulator of the LytR AlgR family
H0H25_RS10990	COG1612	heme a metabolic process
H0H25_RS10995	COG0617	tRNA 3'-terminal CCA addition
H0H25_RS10995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0H25_RS10995	COG0517	IMP dehydrogenase activity
H0H25_RS11005	COG0463	Glycosyl transferase, family 2
H0H25_RS11010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0H25_RS11015	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H0H25_RS11025	COG1215	transferase activity, transferring glycosyl groups
H0H25_RS11030	COG0438	transferase activity, transferring glycosyl groups
H0H25_RS11030	COG4641	Protein conserved in bacteria
H0H25_RS11045	COG0463	Glycosyl transferase, family 2
H0H25_RS11075	COG2171	N-acyltransferase activity
H0H25_RS11085	COG0037	tRNA processing
H0H25_RS11090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0H25_RS11115	COG0628	permease
H0H25_RS11135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0H25_RS11145	COG0205	6-phosphofructokinase activity
H0H25_RS11165	COG0606	chelatase, subunit chli
H0H25_RS11170	COG2962	Rard protein
H0H25_RS11195	COG4206	TonB-dependent receptor
H0H25_RS11200	COG1393	Belongs to the ArsC family
H0H25_RS11205	COG1266	CAAX protease self-immunity
H0H25_RS11220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0H25_RS11250	COG1674	ftsk spoiiie
H0H25_RS11265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0H25_RS11265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0H25_RS11280	COG1309	transcriptional regulator
H0H25_RS11285	COG0183	Belongs to the thiolase family
H0H25_RS11315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H0H25_RS11665	COG0556	nucleotide-excision repair
H0H25_RS11690	COG0045	succinate-CoA ligase (ADP-forming) activity
H0H25_RS11720	COG0450	alkyl hydroperoxide reductase
H0H25_RS11750	COG3278	Belongs to the heme-copper respiratory oxidase family
H0H25_RS11755	COG1136	(ABC) transporter
H0H25_RS11785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0H25_RS11795	COG3012	SEC-C Motif Domain Protein
H0H25_RS11805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0H25_RS11825	COG0463	Glycosyl transferase, family 2
H0H25_RS11855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0H25_RS11890	COG0668	transmembrane transport
H0H25_RS11895	COG1607	acyl-coa hydrolase
H0H25_RS11915	COG0107	imidazoleglycerol-phosphate synthase activity
H0H25_RS11920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0H25_RS11925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0H25_RS11930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H0H25_RS11930	COG0131	Imidazoleglycerol-phosphate dehydratase
H0H25_RS11935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0H25_RS11940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0H25_RS11945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0H25_RS11955	COG1368	sulfuric ester hydrolase activity
H0H25_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
H0H25_RS11970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0H25_RS11990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H0H25_RS12005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0H25_RS12015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0H25_RS12020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0H25_RS12025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0H25_RS12030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0H25_RS12030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0H25_RS12035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0H25_RS12040	COG1078	dGTPase activity
H0H25_RS12050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H0H25_RS12075	COG0116	Belongs to the methyltransferase superfamily
H0H25_RS12075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H0H25_RS12105	COG1309	transcriptional regulator
H0H25_RS12120	COG4716	Myosin-crossreactive antigen
H0H25_RS12125	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0H25_RS12130	COG4716	Myosin-crossreactive antigen
H0H25_RS12140	COG0306	phosphate transporter
H0H25_RS12170	COG1881	PFAM PEBP family protein
H0H25_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
H0H25_RS12210	COG0415	Belongs to the DNA photolyase family
H0H25_RS12215	COG0784	Response regulator, receiver
H0H25_RS12225	COG4251	negative regulation of phosphorylation
H0H25_RS12235	COG4251	negative regulation of phosphorylation
H0H25_RS12245	COG3279	Response regulator of the LytR AlgR family
H0H25_RS12270	COG0069	glutamate synthase activity
H0H25_RS12275	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0H25_RS12280	COG0826	peptidase U32
H0H25_RS12285	COG0022	dehydrogenase e1 component
H0H25_RS12305	COG0813	purine-nucleoside phosphorylase activity
H0H25_RS12310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0H25_RS12335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0H25_RS12355	COG0488	(ABC) transporter
H0H25_RS12380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0H25_RS12385	COG0300	oxidoreductase activity
H0H25_RS12435	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H0H25_RS12445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0H25_RS12455	COG1435	thymidine kinase activity
H0H25_RS12460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0H25_RS12465	COG1970	mechanosensitive ion channel activity
H0H25_RS12470	COG2204	response regulator
H0H25_RS12475	COG0802	atpase or kinase
H0H25_RS12480	COG0686	Belongs to the AlaDH PNT family
H0H25_RS12515	COG3328	transposase activity