locus-tag	class	description
DI487_RS00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DI487_RS00045	COG1575	Belongs to the MenA family. Type 1 subfamily
DI487_RS00065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI487_RS00085	COG1858	cytochrome C peroxidase
DI487_RS00090	COG3384	dioxygenase
DI487_RS00110	COG0424	maF-like protein
DI487_RS00125	COG0513	Belongs to the DEAD box helicase family
DI487_RS00135	COG1278	Cold shock
DI487_RS00195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DI487_RS00220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DI487_RS00220	COG0047	phosphoribosylformylglycinamidine synthase activity
DI487_RS00225	COG1022	Amp-dependent synthetase and ligase
DI487_RS00230	COG1022	Amp-dependent synthetase and ligase
DI487_RS00245	COG1250	3-hydroxyacyl-CoA dehydrogenase
DI487_RS00245	COG1024	Enoyl-CoA hydratase
DI487_RS00250	COG0183	Belongs to the thiolase family
DI487_RS00255	COG1960	acyl-CoA dehydrogenase activity
DI487_RS00270	COG0288	reversible hydration of carbon dioxide
DI487_RS00285	COG0783	Belongs to the Dps family
DI487_RS00315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DI487_RS00335	COG1234	tRNA 3'-trailer cleavage
DI487_RS00350	COG0540	Belongs to the ATCase OTCase family
DI487_RS00355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DI487_RS00370	COG1741	Belongs to the pirin family
DI487_RS00400	COG0488	(ABC) transporter
DI487_RS00410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DI487_RS00415	COG0300	oxidoreductase activity
DI487_RS00425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DI487_RS00425	COG0662	Cupin 2, conserved barrel domain protein
DI487_RS00430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DI487_RS00440	COG3844	kynureninase activity
DI487_RS00460	COG2022	thiamine diphosphate biosynthetic process
DI487_RS00475	COG0443	Heat shock 70 kDa protein
DI487_RS00480	COG0513	Belongs to the DEAD box helicase family
DI487_RS00485	COG1760	l-serine dehydratase
DI487_RS00500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DI487_RS00505	COG0564	pseudouridine synthase activity
DI487_RS00520	COG2321	neutral zinc metallopeptidase
DI487_RS00525	COG3425	synthase
DI487_RS00530	COG0606	chelatase, subunit chli
DI487_RS00545	COG1476	TRANSCRIPTIONal
DI487_RS00560	COG3457	Alanine racemase
DI487_RS00575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DI487_RS00605	COG1506	peptidase
DI487_RS00605	COG0823	Involved in the tonB-independent uptake of proteins
DI487_RS00615	COG0450	alkyl hydroperoxide reductase
DI487_RS00635	COG0798	PFAM Bile acid sodium symporter
DI487_RS00655	COG0640	Transcriptional regulator
DI487_RS00665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DI487_RS00670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DI487_RS00685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DI487_RS00745	COG3279	Response regulator of the LytR AlgR family
DI487_RS00750	COG3275	phosphorelay sensor kinase activity
DI487_RS00775	COG2949	membrane
DI487_RS00815	COG0702	epimerase
DI487_RS00820	COG1733	regulation of RNA biosynthetic process
DI487_RS00845	COG0667	Aldo Keto reductase
DI487_RS00850	COG2217	Heavy metal translocating P-type atpase
DI487_RS00870	COG0318	PFAM AMP-dependent synthetase and ligase
DI487_RS00885	COG0730	response to heat
DI487_RS00890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI487_RS00890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI487_RS00895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI487_RS00905	COG1192	Involved in chromosome partitioning
DI487_RS00935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DI487_RS00945	COG3279	Response regulator of the LytR AlgR family
DI487_RS00950	COG0156	8-amino-7-oxononanoate synthase activity
DI487_RS00955	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DI487_RS00970	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DI487_RS00985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DI487_RS00990	COG2860	membrane
DI487_RS01020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DI487_RS01045	COG1595	DNA-templated transcription, initiation
DI487_RS01055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DI487_RS01080	COG3384	dioxygenase
DI487_RS01090	COG0318	PFAM AMP-dependent synthetase and ligase
DI487_RS01110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DI487_RS01115	COG0513	Belongs to the DEAD box helicase family
DI487_RS01120	COG2706	6-phosphogluconolactonase activity
DI487_RS01135	COG0525	valine-tRNA ligase activity
DI487_RS01165	COG0302	gtp cyclohydrolase
DI487_RS01170	COG0215	cysteine-tRNA ligase activity
DI487_RS01175	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DI487_RS01180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DI487_RS01190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DI487_RS01190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DI487_RS01235	COG2884	Cell division ATP-binding protein ftsE
DI487_RS01245	COG2226	methyltransferase
DI487_RS01250	COG1216	Glycosyl transferase, family 2
DI487_RS01275	COG1215	transferase activity, transferring glycosyl groups
DI487_RS01325	COG0714	Associated with various cellular activities
DI487_RS01345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DI487_RS01355	COG3275	phosphorelay sensor kinase activity
DI487_RS01385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DI487_RS01395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DI487_RS01405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DI487_RS01420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DI487_RS01430	COG0667	Aldo Keto reductase
DI487_RS01445	COG2855	membrane
DI487_RS01450	COG2329	Antibiotic biosynthesis monooxygenase
DI487_RS01465	COG2354	Protein conserved in bacteria
DI487_RS01475	COG3956	TIGRFAM MazG family protein
DI487_RS01485	COG0242	peptide deformylase activity
DI487_RS01495	COG0137	argininosuccinate synthase activity
DI487_RS01500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DI487_RS01515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DI487_RS01520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DI487_RS01525	COG0165	Argininosuccinate lyase
DI487_RS01530	COG1522	sequence-specific DNA binding
DI487_RS01535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DI487_RS01545	COG2171	N-acyltransferase activity
DI487_RS01560	COG0463	Glycosyl transferase, family 2
DI487_RS01565	COG0463	Glycosyl transferase, family 2
DI487_RS01630	COG0617	tRNA 3'-terminal CCA addition
DI487_RS01630	COG0517	IMP dehydrogenase activity
DI487_RS01630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DI487_RS01650	COG3279	Response regulator of the LytR AlgR family
DI487_RS01665	COG3275	phosphorelay sensor kinase activity
DI487_RS01675	COG0346	lactoylglutathione lyase activity
DI487_RS01690	COG1288	antiporter activity
DI487_RS01705	COG0045	succinate-CoA ligase (ADP-forming) activity
DI487_RS01710	COG0019	diaminopimelate decarboxylase activity
DI487_RS01715	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
DI487_RS01740	COG0482	sulfurtransferase activity
DI487_RS01755	COG0706	membrane insertase activity
DI487_RS01760	COG0504	CTP synthase activity
DI487_RS01765	COG3152	Membrane
DI487_RS01770	COG3530	Putative quorum-sensing-regulated virulence factor
DI487_RS01775	COG1846	Transcriptional regulator
DI487_RS01780	COG0386	Belongs to the glutathione peroxidase family
DI487_RS01785	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DI487_RS01795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI487_RS01800	COG0284	orotidine-5'-phosphate decarboxylase activity
DI487_RS01810	COG2201	protein-glutamate methylesterase activity
DI487_RS01815	COG4251	negative regulation of phosphorylation
DI487_RS01855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DI487_RS01860	COG4774	siderophore transport
DI487_RS01875	COG4774	siderophore transport
DI487_RS01885	COG3850	Histidine kinase
DI487_RS01885	COG5002	protein histidine kinase activity
DI487_RS01895	COG0110	maltose O-acetyltransferase activity
DI487_RS01905	COG1881	PFAM PEBP family protein
DI487_RS01910	COG2375	cellular response to nickel ion
DI487_RS01915	COG2207	Transcriptional regulator
DI487_RS01930	COG2195	Cleaves the N-terminal amino acid of tripeptides
DI487_RS01955	COG1252	NADH dehydrogenase
DI487_RS01975	COG0375	protein maturation
DI487_RS01985	COG0298	carbon dioxide binding
DI487_RS01990	COG0309	Hydrogenase expression formation protein (HypE)
DI487_RS02005	COG0545	Peptidyl-prolyl cis-trans isomerase
DI487_RS02010	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DI487_RS02025	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DI487_RS02120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DI487_RS02125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DI487_RS02130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DI487_RS02135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DI487_RS02140	COG0561	phosphatase activity
DI487_RS02145	COG3279	Response regulator of the LytR AlgR family
DI487_RS02215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DI487_RS02235	COG0825	malonyl-CoA metabolic process
DI487_RS02250	COG0343	queuine tRNA-ribosyltransferase activity
DI487_RS02260	COG3958	Transketolase
DI487_RS02290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DI487_RS02310	COG1127	ABC transporter
DI487_RS02315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DI487_RS02330	COG1673	EVE domain
DI487_RS02410	COG4206	TonB-dependent receptor
DI487_RS02415	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DI487_RS02425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI487_RS02430	COG1120	ATPase activity
DI487_RS02450	COG1187	pseudouridine synthase activity
DI487_RS02465	COG1607	acyl-coa hydrolase
DI487_RS02485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DI487_RS02495	COG0730	response to heat
DI487_RS02515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DI487_RS02535	COG0254	rRNA binding
DI487_RS02545	COG0463	Glycosyl transferase, family 2
DI487_RS02555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DI487_RS02560	COG1132	(ABC) transporter
DI487_RS02600	COG1418	mRNA catabolic process
DI487_RS02605	COG4974	Belongs to the 'phage' integrase family
DI487_RS02625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DI487_RS02640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DI487_RS02660	COG0514	ATP-dependent DNA helicase (RecQ)
DI487_RS02675	COG1678	Uncharacterized ACR, COG1678
DI487_RS02705	COG2819	hydrolase of the alpha beta superfamily
DI487_RS02775	COG0124	histidyl-tRNA synthetase
DI487_RS02785	COG2890	protein-(glutamine-N5) methyltransferase activity
DI487_RS02795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DI487_RS02795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DI487_RS02800	COG1011	Hydrolase
DI487_RS02805	COG0697	spore germination
DI487_RS02815	COG0824	Thioesterase
DI487_RS02830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DI487_RS02845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DI487_RS02855	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DI487_RS02880	COG1049	propionate catabolic process, 2-methylcitrate cycle
DI487_RS02885	COG2755	lipolytic protein G-D-S-L family
DI487_RS02885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DI487_RS02895	COG0714	Associated with various cellular activities
DI487_RS02900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DI487_RS02915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DI487_RS02925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DI487_RS02930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DI487_RS02980	COG0446	pyridine nucleotide-disulphide oxidoreductase
DI487_RS03000	COG1129	ABC transporter
DI487_RS03000	COG0842	Transport permease protein
DI487_RS03005	COG0842	Transport permease protein
DI487_RS03010	COG1131	(ABC) transporter
DI487_RS03015	COG1131	(ABC) transporter
DI487_RS03020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DI487_RS03030	COG1309	transcriptional regulator
DI487_RS03035	COG1294	oxidase, subunit
DI487_RS03040	COG1271	oxidase subunit
DI487_RS03075	COG0500	methyltransferase
DI487_RS03090	COG0450	alkyl hydroperoxide reductase
DI487_RS03095	COG1858	cytochrome C peroxidase
DI487_RS03140	COG2197	response regulator
DI487_RS03145	COG4585	Histidine kinase
DI487_RS03155	COG1696	Membrane protein involved in D-alanine export
DI487_RS03170	COG0018	arginyl-trna synthetase
DI487_RS03195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI487_RS03200	COG3842	ATPase activity
DI487_RS03210	COG0326	Molecular chaperone. Has ATPase activity
DI487_RS03215	COG1272	protein, Hemolysin III
DI487_RS03265	COG0667	Aldo Keto reductase
DI487_RS03280	COG1482	cell wall glycoprotein biosynthetic process
DI487_RS03290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DI487_RS03295	COG4651	solute:proton antiporter activity
DI487_RS03295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DI487_RS03300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DI487_RS03300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DI487_RS03305	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DI487_RS03320	COG0750	zinc metalloprotease
DI487_RS03330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DI487_RS03345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DI487_RS03350	COG2239	Acts as a magnesium transporter
DI487_RS03365	COG0514	ATP-dependent DNA helicase (RecQ)
DI487_RS03370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DI487_RS03370	COG0517	IMP dehydrogenase activity
DI487_RS03375	COG0805	protein transport
DI487_RS03380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DI487_RS03385	COG1137	ATPase activity
DI487_RS03415	COG3757	hydrolase, family 25
DI487_RS03420	COG1183	phosphatidylcholine synthase activity
DI487_RS03435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DI487_RS03440	COG0438	transferase activity, transferring glycosyl groups
DI487_RS03450	COG0438	transferase activity, transferring glycosyl groups
DI487_RS03465	COG1045	serine acetyltransferase
DI487_RS03485	COG1083	cytidylyl-transferase
DI487_RS03495	COG2089	acid synthase
DI487_RS03500	COG2201	protein-glutamate methylesterase activity
DI487_RS03505	COG3279	Response regulator of the LytR AlgR family
DI487_RS03515	COG4251	negative regulation of phosphorylation
DI487_RS03535	COG4251	negative regulation of phosphorylation
DI487_RS03550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI487_RS03555	COG1216	Glycosyl transferase, family 2
DI487_RS03555	COG0463	Glycosyl transferase, family 2
DI487_RS03560	COG1216	Glycosyl transferase, family 2
DI487_RS03575	COG0438	transferase activity, transferring glycosyl groups
DI487_RS03585	COG1216	Glycosyl transferase, family 2
DI487_RS03625	COG4464	protein tyrosine phosphatase activity
DI487_RS03630	COG3206	protein involved in exopolysaccharide biosynthesis
DI487_RS03630	COG0489	protein tyrosine kinase activity
DI487_RS03640	COG1086	Polysaccharide biosynthesis protein
DI487_RS03645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DI487_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
DI487_RS03665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI487_RS03675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI487_RS03680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DI487_RS03685	COG0438	transferase activity, transferring glycosyl groups
DI487_RS03690	COG1216	Glycosyl transferase, family 2
DI487_RS03700	COG5039	Polysaccharide pyruvyl transferase
DI487_RS03705	COG1442	glycosyl transferase family 8
DI487_RS03705	COG1216	Glycosyl transferase, family 2
DI487_RS03725	COG0175	sulfate reduction
DI487_RS03745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DI487_RS03750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DI487_RS03755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI487_RS03760	COG0489	protein tyrosine kinase activity
DI487_RS03770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DI487_RS03785	COG2095	MarC family integral membrane protein
DI487_RS03790	COG0175	sulfate reduction
DI487_RS03800	COG1959	2 iron, 2 sulfur cluster binding
DI487_RS03820	COG0148	phosphopyruvate hydratase activity
DI487_RS03825	COG0505	Belongs to the CarA family
DI487_RS03830	COG0203	ribosomal protein L17
DI487_RS03835	COG0202	RNA polymerase activity
DI487_RS03840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DI487_RS03845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DI487_RS03850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DI487_RS03855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DI487_RS03860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DI487_RS03870	COG0200	Binds to the 23S rRNA
DI487_RS03875	COG1841	ribosomal large subunit assembly
DI487_RS03880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DI487_RS03885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DI487_RS03890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DI487_RS03895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DI487_RS03900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DI487_RS03905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DI487_RS03910	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DI487_RS03915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DI487_RS03920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DI487_RS03925	COG0255	Belongs to the universal ribosomal protein uL29 family
DI487_RS03930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DI487_RS03935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DI487_RS03940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DI487_RS03945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DI487_RS03950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DI487_RS03955	COG0089	rRNA binding
DI487_RS03960	COG0088	Forms part of the polypeptide exit tunnel
DI487_RS03965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DI487_RS03970	COG0051	transcription antitermination factor activity, RNA binding
DI487_RS03975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DI487_RS03980	COG0049	tRNA binding
DI487_RS03985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DI487_RS03995	COG0366	Alpha amylase catalytic
DI487_RS04000	COG1082	Xylose isomerase domain protein TIM barrel
DI487_RS04005	COG1554	hydrolase, family 65, central catalytic
DI487_RS04010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DI487_RS04025	COG4206	TonB-dependent receptor
DI487_RS04025	COG1629	transport
DI487_RS04030	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DI487_RS04045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DI487_RS04055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DI487_RS04105	COG0778	Nitroreductase
DI487_RS04120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DI487_RS04130	COG1011	Hydrolase
DI487_RS04145	COG1136	(ABC) transporter
DI487_RS04150	COG2003	Belongs to the UPF0758 family
DI487_RS04155	COG3738	Protein conserved in bacteria
DI487_RS04160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DI487_RS04175	COG3591	Belongs to the peptidase S1B family
DI487_RS04180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DI487_RS04185	COG0563	adenylate kinase activity
DI487_RS04195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DI487_RS04200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DI487_RS04255	COG2346	COG2346, Truncated hemoglobins
DI487_RS04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI487_RS04270	COG1215	transferase activity, transferring glycosyl groups
DI487_RS04275	COG1215	transferase activity, transferring glycosyl groups
DI487_RS04280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DI487_RS04285	COG1127	ABC transporter
DI487_RS04315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DI487_RS04320	COG0295	cytidine deaminase activity
DI487_RS04335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DI487_RS04340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DI487_RS04345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI487_RS04350	COG0667	Aldo Keto reductase
DI487_RS04355	COG1360	Flagellar Motor Protein
DI487_RS04360	COG0708	Exodeoxyribonuclease III
DI487_RS04385	COG0285	dihydrofolate synthase activity
DI487_RS04395	COG0848	biopolymer transport protein
DI487_RS04400	COG0811	peptide transport
DI487_RS04405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DI487_RS04415	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DI487_RS04420	COG1960	acyl-CoA dehydrogenase activity
DI487_RS04425	COG0069	glutamate synthase activity
DI487_RS04425	COG0067	glutamate synthase
DI487_RS04425	COG0070	glutamate synthase
DI487_RS04465	COG3876	Protein conserved in bacteria
DI487_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
DI487_RS04485	COG0500	methyltransferase
DI487_RS04500	COG0602	queuosine metabolic process
DI487_RS04530	COG1490	D-aminoacyl-tRNA deacylase activity
DI487_RS04535	COG1162	GTPase activity
DI487_RS04545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DI487_RS04550	COG0287	Prephenate dehydrogenase
DI487_RS04555	COG0436	Aminotransferase
DI487_RS04585	COG0646	methionine synthase
DI487_RS04585	COG1410	methionine synthase
DI487_RS04595	COG0460	homoserine dehydrogenase
DI487_RS04595	COG0527	aspartate kinase activity
DI487_RS04600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DI487_RS04615	COG1045	serine acetyltransferase
DI487_RS04620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DI487_RS04645	COG1428	Deoxynucleoside kinase
DI487_RS04650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DI487_RS04660	COG0022	dehydrogenase e1 component
DI487_RS04660	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI487_RS04665	COG2086	electron transfer activity
DI487_RS04670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DI487_RS04680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DI487_RS04685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DI487_RS04690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DI487_RS04695	COG2226	methyltransferase
DI487_RS04715	COG0191	fructose-bisphosphate aldolase activity
DI487_RS04720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DI487_RS04725	COG4771	TonB-dependent receptor
DI487_RS04755	COG0586	Pfam SNARE associated Golgi protein
DI487_RS04775	COG0439	Biotin carboxylase
DI487_RS04780	COG0511	ligase activity, forming carbon-carbon bonds
DI487_RS04785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI487_RS04790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DI487_RS04800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DI487_RS04845	COG2003	Belongs to the UPF0758 family
DI487_RS04925	COG0346	lactoylglutathione lyase activity
DI487_RS04930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DI487_RS04935	COG4591	ABC-type transport system involved in lipoprotein release permease component
DI487_RS04940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DI487_RS04945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DI487_RS04950	COG0612	Peptidase, M16
DI487_RS04980	COG0629	single-stranded DNA binding
DI487_RS05000	COG1530	ribonuclease E activity
DI487_RS05005	COG4953	penicillin-binding protein 1C
DI487_RS05010	COG2373	Large extracellular alpha-helical protein
DI487_RS05015	COG0590	tRNA wobble adenosine to inosine editing
DI487_RS05040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DI487_RS05060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DI487_RS05075	COG0481	GTPase activity
DI487_RS05085	COG1187	pseudouridine synthase activity
DI487_RS05110	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DI487_RS05115	COG2081	HI0933 family
DI487_RS05120	COG0584	glycerophosphoryl diester phosphodiesterase
DI487_RS05135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DI487_RS05160	COG4536	flavin adenine dinucleotide binding
DI487_RS05165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DI487_RS05175	COG4974	Belongs to the 'phage' integrase family
DI487_RS05435	COG2217	Heavy metal translocating P-type atpase
DI487_RS05455	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DI487_RS05470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DI487_RS05470	COG1017	nitric oxide dioxygenase activity
DI487_RS05485	COG2963	transposase activity
DI487_RS05540	COG2217	Heavy metal translocating P-type atpase
DI487_RS05550	COG1764	response to oxidative stress
DI487_RS05560	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DI487_RS05575	COG2132	Multicopper oxidase
DI487_RS05580	COG2814	Major facilitator Superfamily
DI487_RS05600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DI487_RS05610	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DI487_RS05615	COG0791	NLP P60 protein
DI487_RS05620	COG0658	competence protein
DI487_RS05620	COG2333	competence protein COMEC
DI487_RS05625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI487_RS05635	COG3104	oligopeptide transport
DI487_RS05640	COG0823	Involved in the tonB-independent uptake of proteins
DI487_RS05640	COG1506	peptidase
DI487_RS05645	COG2205	protein histidine kinase activity
DI487_RS05645	COG3850	Histidine kinase
DI487_RS05645	COG4999	Histidine kinase
DI487_RS05645	COG3437	response regulator, receiver
DI487_RS05665	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DI487_RS05670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DI487_RS05670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DI487_RS05685	COG2095	MarC family integral membrane protein
DI487_RS05715	COG0527	aspartate kinase activity
DI487_RS05725	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DI487_RS05745	COG0793	Belongs to the peptidase S41A family
DI487_RS05755	COG0720	synthase
DI487_RS05775	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DI487_RS05785	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DI487_RS05785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DI487_RS05790	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DI487_RS05800	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DI487_RS05810	COG1435	thymidine kinase activity
DI487_RS05815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DI487_RS05820	COG1970	mechanosensitive ion channel activity
DI487_RS05825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DI487_RS05845	COG4771	TonB-dependent receptor
DI487_RS05870	COG0138	bifunctional purine biosynthesis protein purh
DI487_RS05875	COG1077	Cell shape determining protein MreB Mrl
DI487_RS05895	COG0772	Belongs to the SEDS family
DI487_RS05905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DI487_RS05910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DI487_RS05920	COG0193	aminoacyl-tRNA hydrolase activity
DI487_RS05940	COG0196	riboflavin kinase activity
DI487_RS05970	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DI487_RS05975	COG3279	Response regulator of the LytR AlgR family
DI487_RS05980	COG3275	phosphorelay sensor kinase activity
DI487_RS05985	COG0577	efflux transmembrane transporter activity
DI487_RS05985	COG1136	(ABC) transporter
DI487_RS05990	COG1136	(ABC) transporter
DI487_RS05995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DI487_RS06010	COG0423	glycine-tRNA ligase activity
DI487_RS06020	COG1040	competence protein
DI487_RS06030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DI487_RS06035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DI487_RS06040	COG1053	succinate dehydrogenase
DI487_RS06050	COG0006	proline dipeptidase activity
DI487_RS06060	COG2378	regulation of single-species biofilm formation
DI487_RS06065	COG2267	carboxylic ester hydrolase activity
DI487_RS06080	COG0156	8-amino-7-oxononanoate synthase activity
DI487_RS06085	COG1074	ATP-dependent DNA helicase activity
DI487_RS06105	COG3341	Caulimovirus viroplasmin
DI487_RS06105	COG0328	RNA-DNA hybrid ribonuclease activity
DI487_RS06110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DI487_RS06115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DI487_RS06120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DI487_RS06125	COG0571	ribonuclease III activity
DI487_RS06135	COG0469	pyruvate kinase activity
DI487_RS06140	COG3590	peptidase
DI487_RS06150	COG1999	signal sequence binding
DI487_RS06210	COG1418	mRNA catabolic process
DI487_RS06215	COG3540	Alkaline phosphatase
DI487_RS06220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DI487_RS06225	COG0758	DNA mediated transformation
DI487_RS06225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DI487_RS06230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DI487_RS06245	COG2954	triphosphatase activity
DI487_RS06250	COG1309	transcriptional regulator
DI487_RS06255	COG1538	Outer membrane efflux protein
DI487_RS06265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DI487_RS06275	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DI487_RS06290	COG0166	Belongs to the GPI family
DI487_RS06310	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DI487_RS06315	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DI487_RS06325	COG0322	excinuclease ABC activity
DI487_RS06340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DI487_RS06345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DI487_RS06355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DI487_RS06360	COG1381	Involved in DNA repair and RecF pathway recombination
DI487_RS06370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DI487_RS06380	COG0626	cystathionine gamma-synthase activity
DI487_RS06405	COG0194	GDP metabolic process
DI487_RS06410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DI487_RS06415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DI487_RS06420	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DI487_RS06440	COG1397	ADP-ribosylglycohydrolase
DI487_RS06445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DI487_RS06450	COG1051	belongs to the nudix hydrolase family
DI487_RS06450	COG1056	cytidyltransferase-related domain
DI487_RS06470	COG3537	Alpha-1,2-mannosidase
DI487_RS06485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DI487_RS06490	COG0385	Bile acid
DI487_RS06505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DI487_RS06540	COG2304	oxidoreductase activity
DI487_RS06545	COG2304	oxidoreductase activity
DI487_RS06560	COG0714	Associated with various cellular activities
DI487_RS06565	COG4989	oxidoreductase activity
DI487_RS06580	COG2197	response regulator
DI487_RS06585	COG4585	Histidine kinase
DI487_RS06610	COG2824	Alkylphosphonate utilization operon protein PhnA
DI487_RS06615	COG1012	belongs to the aldehyde dehydrogenase family
DI487_RS06645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DI487_RS06660	COG2151	metal-sulfur cluster biosynthetic enzyme
DI487_RS06665	COG0531	amino acid
DI487_RS06670	COG2166	iron-sulfur cluster assembly
DI487_RS06680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DI487_RS06695	COG0719	Fe-S assembly protein
DI487_RS06700	COG0396	ATPase activity
DI487_RS06705	COG0655	NAD(P)H dehydrogenase (quinone) activity
DI487_RS06715	COG0719	Fe-S assembly protein
DI487_RS06725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI487_RS06830	COG1876	peptidase activity
DI487_RS06845	COG3621	Patatin-like phospholipase
DI487_RS06855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DI487_RS06860	COG0594	ribonuclease P activity
DI487_RS06865	COG0793	Belongs to the peptidase S41A family
DI487_RS06865	COG3409	Peptidoglycan-binding domain 1 protein
DI487_RS06885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DI487_RS06890	COG2153	protein acetylation
DI487_RS06900	COG1388	LysM domain
DI487_RS06900	COG3942	CHAP domain
DI487_RS06905	COG0126	phosphoglycerate kinase activity
DI487_RS06910	COG0470	DNA polymerase III
DI487_RS06925	COG0183	Belongs to the thiolase family
DI487_RS06935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DI487_RS06940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DI487_RS06955	COG4948	Mandelate Racemase Muconate Lactonizing
DI487_RS06960	COG0477	Major facilitator Superfamily
DI487_RS06975	COG2814	Major facilitator Superfamily
DI487_RS06990	COG4638	Rieske (2fe-2S)
DI487_RS07005	COG2226	methyltransferase
DI487_RS07010	COG0445	tRNA wobble uridine modification
DI487_RS07015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DI487_RS07040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DI487_RS07045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DI487_RS07050	COG1368	sulfuric ester hydrolase activity
DI487_RS07070	COG0557	exoribonuclease II activity
DI487_RS07095	COG2183	response to ionizing radiation
DI487_RS07100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DI487_RS07155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI487_RS07160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DI487_RS07175	COG0463	Glycosyl transferase, family 2
DI487_RS07240	COG1215	transferase activity, transferring glycosyl groups
DI487_RS07265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DI487_RS07275	COG0859	PFAM glycosyl transferase family 9
DI487_RS07295	COG1607	acyl-coa hydrolase
DI487_RS07325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DI487_RS07340	COG0700	Nucleoside recognition
DI487_RS07350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DI487_RS07350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DI487_RS07355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DI487_RS07370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DI487_RS07385	COG1774	PSP1 C-terminal conserved region
DI487_RS07400	COG1054	Belongs to the UPF0176 family
DI487_RS07420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DI487_RS07445	COG0180	Tryptophanyl-tRNA synthetase
DI487_RS07450	COG1024	Enoyl-CoA hydratase
DI487_RS07460	COG1981	membrane
DI487_RS07470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DI487_RS07495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DI487_RS07500	COG0181	hydroxymethylbilane synthase activity
DI487_RS07505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DI487_RS07510	COG0569	domain protein
DI487_RS07520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DI487_RS07530	COG0408	coproporphyrinogen oxidase activity
DI487_RS07550	COG0113	porphobilinogen synthase activity
DI487_RS07585	COG3153	acetyltransferase
DI487_RS07585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DI487_RS07590	COG0629	single-stranded DNA binding
DI487_RS07595	COG0629	single-stranded DNA binding
DI487_RS07610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DI487_RS07625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DI487_RS07635	COG0297	glycogen (starch) synthase activity
DI487_RS07645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DI487_RS07665	COG4206	TonB-dependent receptor
DI487_RS07675	COG1278	Cold shock
DI487_RS07685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DI487_RS07690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI487_RS07740	COG0567	Dehydrogenase, E1 component
DI487_RS07745	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI487_RS07750	COG1528	Iron-storage protein
DI487_RS07755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI487_RS07755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI487_RS07765	COG0792	nuclease activity
DI487_RS07795	COG0356	it plays a direct role in the translocation of protons across the membrane
DI487_RS07800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DI487_RS07805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DI487_RS07810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DI487_RS07820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DI487_RS07825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DI487_RS07830	COG1505	serine-type exopeptidase activity
DI487_RS07840	COG0756	dUTP diphosphatase activity
DI487_RS07900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DI487_RS07915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI487_RS07930	COG0084	hydrolase, TatD family'
DI487_RS07940	COG0252	asparaginase activity
DI487_RS07950	COG0811	peptide transport
DI487_RS07980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DI487_RS07985	COG0017	Asparaginyl-tRNA synthetase
DI487_RS08000	COG0233	cytoplasmic translational termination
DI487_RS08005	COG0528	UMP kinase activity
DI487_RS08080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DI487_RS08085	COG1968	undecaprenyl-diphosphatase activity
DI487_RS08095	COG2177	Part of the ABC transporter FtsEX involved in
DI487_RS08100	COG0495	leucyl-tRNA aminoacylation
DI487_RS08125	COG1522	sequence-specific DNA binding
DI487_RS08135	COG2363	Small membrane protein
DI487_RS08140	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DI487_RS08160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DI487_RS08170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI487_RS08175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DI487_RS08220	COG5002	protein histidine kinase activity
DI487_RS08225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI487_RS08230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DI487_RS08250	COG2204	response regulator
DI487_RS08265	COG1136	(ABC) transporter
DI487_RS08265	COG0577	efflux transmembrane transporter activity
DI487_RS08300	COG0489	protein tyrosine kinase activity
DI487_RS08310	COG0492	ferredoxin-NADP+ reductase activity
DI487_RS08315	COG0633	Ferredoxin
DI487_RS08320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DI487_RS08355	COG3720	iron ion transport
DI487_RS08365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI487_RS08375	COG4206	TonB-dependent receptor
DI487_RS08395	COG1960	acyl-CoA dehydrogenase activity
DI487_RS08405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DI487_RS08410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DI487_RS08415	COG0228	four-way junction DNA binding
DI487_RS08450	COG3118	belongs to the thioredoxin family
DI487_RS08470	COG3620	sequence-specific DNA binding
DI487_RS08565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DI487_RS08595	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DI487_RS08600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DI487_RS08615	COG2315	Protein conserved in bacteria
DI487_RS08620	COG0446	pyridine nucleotide-disulphide oxidoreductase
DI487_RS08635	COG3852	Histidine kinase
DI487_RS08645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DI487_RS08660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DI487_RS08675	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DI487_RS08685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DI487_RS08695	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DI487_RS08700	COG0739	heme binding
DI487_RS08705	COG0519	Catalyzes the synthesis of GMP from XMP
DI487_RS08710	COG4628	conserved protein (DUF2132)
DI487_RS08715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DI487_RS08720	COG0052	Belongs to the universal ribosomal protein uS2 family
DI487_RS08725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DI487_RS08735	COG1609	Transcriptional regulator
DI487_RS08750	COG1073	alpha beta
DI487_RS08755	COG5658	integral membrane protein
DI487_RS08760	COG0640	Transcriptional regulator
DI487_RS08765	COG2264	protein methyltransferase activity
DI487_RS08820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DI487_RS08835	COG1408	metallophosphoesterase
DI487_RS08870	COG0195	Participates in both transcription termination and antitermination
DI487_RS08875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DI487_RS08890	COG0437	4 iron, 4 sulfur cluster binding
DI487_RS08915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DI487_RS08920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DI487_RS08925	COG2255	four-way junction helicase activity
DI487_RS08930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DI487_RS08935	COG1609	Transcriptional regulator
DI487_RS08955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI487_RS08970	COG0632	four-way junction helicase activity
DI487_RS08980	COG0509	glycine decarboxylation via glycine cleavage system
DI487_RS09000	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DI487_RS09010	COG0109	protoheme IX farnesyltransferase activity
DI487_RS09035	COG1999	signal sequence binding
DI487_RS09040	COG2322	membrane
DI487_RS09065	COG1214	PFAM Peptidase M22, glycoprotease
DI487_RS09070	COG0668	transmembrane transport
DI487_RS09080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DI487_RS09105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DI487_RS09110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DI487_RS09125	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DI487_RS09130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DI487_RS09140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DI487_RS09150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DI487_RS09155	COG0596	Alpha beta hydrolase
DI487_RS09170	COG1950	PFAM Membrane protein of
DI487_RS09175	COG0544	peptidyl-prolyl cis-trans isomerase activity
DI487_RS09185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DI487_RS09190	COG3047	cAMP biosynthetic process
DI487_RS09190	COG2885	chlorophyll binding
DI487_RS09215	COG0616	signal peptide processing
DI487_RS09220	COG1428	Deoxynucleoside kinase
DI487_RS09260	COG4717	serine-type aminopeptidase activity
DI487_RS09275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI487_RS09295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DI487_RS09300	COG2353	YceI-like domain
DI487_RS09305	COG1741	Belongs to the pirin family
DI487_RS09335	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DI487_RS09345	COG3239	Fatty acid desaturase
DI487_RS09350	COG0357	Ribosomal RNA small subunit methyltransferase G
DI487_RS09360	COG2967	ApaG domain
DI487_RS09375	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DI487_RS09380	COG1805	sodium ion transport
DI487_RS09385	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DI487_RS09390	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DI487_RS09395	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DI487_RS09410	COG1477	protein flavinylation
DI487_RS09415	COG2226	methyltransferase
DI487_RS09425	COG0427	acetyl-CoA hydrolase
DI487_RS09455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DI487_RS09470	COG2989	Protein conserved in bacteria
DI487_RS09490	COG3340	Belongs to the peptidase S51 family
DI487_RS09515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DI487_RS09520	COG0671	phosphoesterase, PA-phosphatase related
DI487_RS09530	COG0069	glutamate synthase activity
DI487_RS09535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DI487_RS09560	COG0358	DNA primase activity
DI487_RS09570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DI487_RS09585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DI487_RS09595	COG2001	Belongs to the MraZ family
DI487_RS09610	COG0768	penicillin binding
DI487_RS09615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DI487_RS09620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DI487_RS09625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DI487_RS09635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI487_RS09640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DI487_RS09660	COG1610	YqeY-like protein
DI487_RS09680	COG0583	DNA-binding transcription factor activity
DI487_RS09685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DI487_RS09700	COG0745	RESPONSE REGULATOR receiver
DI487_RS09715	COG1368	sulfuric ester hydrolase activity
DI487_RS09735	COG3275	phosphorelay sensor kinase activity
DI487_RS09750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DI487_RS09750	COG3620	sequence-specific DNA binding
DI487_RS09750	COG0617	tRNA 3'-terminal CCA addition
DI487_RS09755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DI487_RS09760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DI487_RS09770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DI487_RS09775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DI487_RS09785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI487_RS09790	COG1309	transcriptional regulator
DI487_RS09835	COG2205	protein histidine kinase activity
DI487_RS09885	COG1690	Belongs to the RtcB family
DI487_RS09905	COG1185	polyribonucleotide nucleotidyltransferase activity
DI487_RS09910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DI487_RS09935	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DI487_RS09960	COG0459	protein refolding
DI487_RS09965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DI487_RS09990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DI487_RS10035	COG0488	(ABC) transporter
DI487_RS10070	COG2197	response regulator
DI487_RS10115	COG2314	TM2 domain
DI487_RS10175	COG1476	TRANSCRIPTIONal
DI487_RS10220	COG1476	TRANSCRIPTIONal
DI487_RS10300	COG2003	Belongs to the UPF0758 family
DI487_RS10370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DI487_RS10380	COG1160	GTP binding
DI487_RS10390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DI487_RS10400	COG0066	3-isopropylmalate dehydratase activity
DI487_RS10405	COG0473	3-isopropylmalate dehydrogenase activity
DI487_RS10425	COG1704	LemA family
DI487_RS10440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DI487_RS10490	COG4585	Histidine kinase
DI487_RS10495	COG4585	Histidine kinase
DI487_RS10500	COG2885	chlorophyll binding
DI487_RS10520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI487_RS10525	COG3186	Phenylalanine-4-hydroxylase
DI487_RS10540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DI487_RS10545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DI487_RS10550	COG0440	acetolactate synthase activity
DI487_RS10555	COG0028	Belongs to the TPP enzyme family
DI487_RS10635	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DI487_RS10645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DI487_RS10655	COG0534	Mate efflux family protein
DI487_RS10660	COG2326	polyphosphate kinase activity
DI487_RS10690	COG1858	cytochrome C peroxidase
DI487_RS10700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DI487_RS10705	COG0321	lipoyl(octanoyl) transferase activity
DI487_RS10710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DI487_RS10715	COG1629	transport
DI487_RS10765	COG0733	neurotransmitter:sodium symporter activity
DI487_RS10775	COG1960	acyl-CoA dehydrogenase activity
DI487_RS10780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI487_RS10785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DI487_RS10790	COG4974	Belongs to the 'phage' integrase family
DI487_RS10795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DI487_RS10815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DI487_RS10835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DI487_RS10840	COG0081	regulation of translation
DI487_RS10845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DI487_RS10850	COG0222	ribosome binding
DI487_RS10855	COG0085	RNA polymerase activity
DI487_RS10875	COG1187	pseudouridine synthase activity
DI487_RS10885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DI487_RS10895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DI487_RS10900	COG1663	tetraacyldisaccharide 4'-kinase activity
DI487_RS10905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DI487_RS10925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DI487_RS10930	COG1595	DNA-templated transcription, initiation
DI487_RS10935	COG1215	transferase activity, transferring glycosyl groups
DI487_RS10945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DI487_RS10950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DI487_RS10960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DI487_RS10970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DI487_RS10995	COG0681	Belongs to the peptidase S26 family
DI487_RS11000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DI487_RS11010	COG1475	DNA binding
DI487_RS11015	COG1192	Involved in chromosome partitioning
DI487_RS11025	COG0840	transmembrane signaling receptor activity
DI487_RS11040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DI487_RS11075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DI487_RS11075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DI487_RS11080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DI487_RS11080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DI487_RS11100	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DI487_RS11105	COG0352	thiamine-phosphate diphosphorylase activity
DI487_RS11115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DI487_RS11125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DI487_RS11135	COG0492	ferredoxin-NADP+ reductase activity
DI487_RS11155	COG1695	Transcriptional regulator
DI487_RS11180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DI487_RS11185	COG0484	heat shock protein binding
DI487_RS11190	COG4152	abc transporter atp-binding protein
DI487_RS11230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DI487_RS11235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DI487_RS11235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DI487_RS11235	COG1703	isobutyryl-CoA mutase activity
DI487_RS11255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI487_RS11265	COG5002	protein histidine kinase activity
DI487_RS11280	COG3275	phosphorelay sensor kinase activity
DI487_RS11340	COG0519	Catalyzes the synthesis of GMP from XMP
DI487_RS11340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DI487_RS11345	COG1388	LysM domain
DI487_RS11345	COG0791	NLP P60 protein
DI487_RS11355	COG0488	(ABC) transporter
DI487_RS11370	COG2304	oxidoreductase activity
DI487_RS11385	COG2197	response regulator
DI487_RS11390	COG4585	Histidine kinase
DI487_RS11425	COG1703	isobutyryl-CoA mutase activity
DI487_RS11435	COG0277	FAD linked oxidase domain protein
DI487_RS11440	COG2255	four-way junction helicase activity
DI487_RS11455	COG1842	Phage shock protein A
DI487_RS11470	COG0653	protein targeting
DI487_RS11485	COG1136	(ABC) transporter
DI487_RS11490	COG0288	reversible hydration of carbon dioxide
DI487_RS11500	COG0488	(ABC) transporter
DI487_RS11515	COG1215	transferase activity, transferring glycosyl groups
DI487_RS11520	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI487_RS11545	COG0179	Fumarylacetoacetate (FAA) hydrolase
DI487_RS11555	COG1546	Belongs to the CinA family
DI487_RS11555	COG1058	Belongs to the CinA family
DI487_RS11560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DI487_RS11565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DI487_RS11575	COG0552	protein localization to endoplasmic reticulum
DI487_RS11590	COG1611	Belongs to the LOG family
DI487_RS11605	COG2224	Isocitrate lyase
DI487_RS11610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DI487_RS11620	COG0105	UTP biosynthetic process
DI487_RS11630	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DI487_RS11645	COG4770	biotin carboxylase activity
DI487_RS11650	COG0439	Biotin carboxylase
DI487_RS11655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DI487_RS11660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI487_RS11660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI487_RS11665	COG0791	NLP P60 protein
DI487_RS11680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DI487_RS11715	COG0268	Binds directly to 16S ribosomal RNA
DI487_RS11720	COG1217	gtp-binding protein TYPA
DI487_RS11730	COG0545	Peptidyl-prolyl cis-trans isomerase
DI487_RS11735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DI487_RS11740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DI487_RS11750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DI487_RS11755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DI487_RS11765	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DI487_RS11770	COG1131	(ABC) transporter
DI487_RS11795	COG1136	(ABC) transporter
DI487_RS11800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DI487_RS11840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI487_RS11845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DI487_RS11855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DI487_RS11870	COG0012	GTP binding
DI487_RS11920	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DI487_RS11930	COG2226	methyltransferase
DI487_RS11965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DI487_RS11970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DI487_RS11975	COG1573	uracil-dna glycosylase
DI487_RS11980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DI487_RS11990	COG0688	phosphatidylethanolamine metabolic process
DI487_RS11995	COG4589	Belongs to the CDS family
DI487_RS12005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DI487_RS12010	COG0799	negative regulation of ribosome biogenesis
DI487_RS12020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DI487_RS12020	COG1333	cytochrome c biogenesis protein
DI487_RS12025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DI487_RS12030	COG0386	Belongs to the glutathione peroxidase family
DI487_RS12045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DI487_RS12060	COG1295	ribonuclease BN
DI487_RS12070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DI487_RS12075	COG3279	Response regulator of the LytR AlgR family
DI487_RS12080	COG0360	Binds together with S18 to 16S ribosomal RNA
DI487_RS12085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DI487_RS12090	COG0359	binds to the 23S rRNA
DI487_RS12120	COG0737	Belongs to the 5'-nucleotidase family
DI487_RS12125	COG0737	Belongs to the 5'-nucleotidase family
DI487_RS12160	COG0497	DNA recombination
DI487_RS12165	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DI487_RS12190	COG0237	dephospho-CoA kinase activity
DI487_RS12260	COG4206	TonB-dependent receptor
DI487_RS12260	COG1629	transport
DI487_RS12265	COG0702	epimerase
DI487_RS12285	COG1472	Belongs to the glycosyl hydrolase 3 family
DI487_RS12305	COG1104	cysteine desulfurase activity
DI487_RS12330	COG2356	endonuclease I
DI487_RS12335	COG1309	transcriptional regulator
DI487_RS12340	COG1764	response to oxidative stress
DI487_RS12345	COG1611	Belongs to the LOG family
DI487_RS12365	COG1024	Enoyl-CoA hydratase
DI487_RS12365	COG1250	3-hydroxyacyl-CoA dehydrogenase
DI487_RS12390	COG0038	chloride channel
DI487_RS12400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DI487_RS12410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DI487_RS12415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DI487_RS12420	COG2176	DNA-directed DNA polymerase activity
DI487_RS12430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DI487_RS12445	COG1250	3-hydroxyacyl-CoA dehydrogenase
DI487_RS12450	COG0673	inositol 2-dehydrogenase activity
DI487_RS12455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DI487_RS12470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DI487_RS12475	COG3047	cAMP biosynthetic process
DI487_RS12490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI487_RS12515	COG0542	response to heat
DI487_RS12555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DI487_RS12560	COG2234	aminopeptidase activity
DI487_RS12690	COG2217	Heavy metal translocating P-type atpase
DI487_RS12705	COG2132	Multicopper oxidase
DI487_RS12730	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DI487_RS12745	COG2217	Heavy metal translocating P-type atpase
DI487_RS12755	COG1566	PFAM secretion protein HlyD family protein
DI487_RS12905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DI487_RS12920	COG0702	epimerase
DI487_RS12925	COG1733	regulation of RNA biosynthetic process
DI487_RS12960	COG4221	oxidoreductase activity
DI487_RS12985	COG1309	transcriptional regulator
DI487_RS13005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DI487_RS13005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DI487_RS13020	COG1674	ftsk spoiiie
DI487_RS13030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DI487_RS13040	COG0840	transmembrane signaling receptor activity
DI487_RS13085	COG4807	Protein conserved in bacteria
DI487_RS13140	COG0335	large ribosomal subunit rRNA binding
DI487_RS13145	COG1917	Cupin 2, conserved barrel domain protein
DI487_RS13145	COG4977	sequence-specific DNA binding
DI487_RS13165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DI487_RS13170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DI487_RS13335	COG2856	Zn peptidase
DI487_RS13360	COG4974	Belongs to the 'phage' integrase family
DI487_RS13385	COG0592	DNA-directed DNA polymerase activity
DI487_RS13420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DI487_RS13430	COG1363	Peptidase, m42
DI487_RS13480	COG0149	triose-phosphate isomerase activity
DI487_RS13485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI487_RS13500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DI487_RS13515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DI487_RS13525	COG1595	DNA-templated transcription, initiation
DI487_RS13530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DI487_RS13535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DI487_RS13545	COG1132	(ABC) transporter
DI487_RS13555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DI487_RS13575	COG2234	aminopeptidase activity
DI487_RS13580	COG2195	Cleaves the N-terminal amino acid of tripeptides
DI487_RS13585	COG0167	dihydroorotate dehydrogenase activity
DI487_RS13600	COG0517	IMP dehydrogenase activity
DI487_RS13600	COG0516	GMP reductase activity
DI487_RS13610	COG2755	lipolytic protein G-D-S-L family
DI487_RS13610	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DI487_RS13620	COG1472	Belongs to the glycosyl hydrolase 3 family
DI487_RS13625	COG0667	Aldo Keto reductase
DI487_RS13645	COG2942	2-epimerase
DI487_RS13650	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
DI487_RS13665	COG2169	Transcriptional regulator
DI487_RS13710	COG3022	response to hydroperoxide
DI487_RS13780	COG0697	spore germination
DI487_RS13785	COG2207	Transcriptional regulator
DI487_RS13785	COG4753	response regulator
DI487_RS13795	COG4977	sequence-specific DNA binding
DI487_RS13795	COG1917	Cupin 2, conserved barrel domain protein
DI487_RS13800	COG1028	Short-chain dehydrogenase reductase Sdr
DI487_RS13805	COG0159	tryptophan synthase activity
DI487_RS13810	COG0133	tryptophan synthase activity
DI487_RS13815	COG0135	phosphoribosylanthranilate isomerase activity
DI487_RS13820	COG0134	indole-3-glycerol-phosphate synthase activity
DI487_RS13825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DI487_RS13830	COG0512	Glutamine amidotransferase of anthranilate synthase
DI487_RS13835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DI487_RS13875	COG0596	Alpha beta hydrolase
DI487_RS13880	COG2353	YceI-like domain
DI487_RS13885	COG0778	Nitroreductase
DI487_RS13895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI487_RS13905	COG1054	Belongs to the UPF0176 family
DI487_RS13915	COG2217	Heavy metal translocating P-type atpase
DI487_RS13925	COG3278	Belongs to the heme-copper respiratory oxidase family
DI487_RS13975	COG0840	transmembrane signaling receptor activity
DI487_RS13990	COG1595	DNA-templated transcription, initiation
DI487_RS13995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DI487_RS14000	COG0415	Belongs to the DNA photolyase family
DI487_RS14015	COG0564	pseudouridine synthase activity
DI487_RS14025	COG1181	Belongs to the D-alanine--D-alanine ligase family
DI487_RS14035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DI487_RS14050	COG0659	secondary active sulfate transmembrane transporter activity
DI487_RS14070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DI487_RS14130	COG0488	(ABC) transporter
DI487_RS14170	COG0010	Belongs to the arginase family
DI487_RS14180	COG1228	amidohydrolase
DI487_RS14185	COG0598	Magnesium transport protein CorA
DI487_RS14205	COG0346	lactoylglutathione lyase activity
DI487_RS14210	COG1393	Belongs to the ArsC family
DI487_RS14240	COG0564	pseudouridine synthase activity
DI487_RS14245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DI487_RS14285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DI487_RS14300	COG0791	NLP P60 protein
DI487_RS14305	COG0183	Belongs to the thiolase family
DI487_RS14335	COG1607	acyl-coa hydrolase
DI487_RS14350	COG0628	permease
DI487_RS14360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DI487_RS14375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DI487_RS14400	COG1803	Methylglyoxal synthase
DI487_RS14415	COG0251	oxidation-reduction process
DI487_RS14425	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI487_RS14435	COG0247	lactate metabolic process
DI487_RS14435	COG2181	nitrate reductase activity
DI487_RS14440	COG2181	nitrate reductase activity
DI487_RS14440	COG0247	lactate metabolic process
DI487_RS14450	COG3830	Belongs to the UPF0237 family
DI487_RS14450	COG0560	Phosphoserine phosphatase
DI487_RS14455	COG1472	Belongs to the glycosyl hydrolase 3 family
DI487_RS14465	COG0438	transferase activity, transferring glycosyl groups
DI487_RS14485	COG0217	transcriptional regulatory protein
DI487_RS14500	COG0793	Belongs to the peptidase S41A family
DI487_RS14515	COG0083	homoserine kinase activity
DI487_RS14520	COG0460	homoserine dehydrogenase
DI487_RS14520	COG0527	aspartate kinase activity
DI487_RS14525	COG2986	histidine ammonia-lyase
DI487_RS14535	COG2259	Doxx family
DI487_RS14555	COG4067	protein conserved in archaea
DI487_RS14555	COG0189	ligase activity
DI487_RS14560	COG0542	response to heat
DI487_RS14565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DI487_RS14590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DI487_RS14595	COG3011	Protein conserved in bacteria
DI487_RS14600	COG1193	negative regulation of DNA recombination
DI487_RS14605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DI487_RS14635	COG0427	acetyl-CoA hydrolase
DI487_RS14650	COG0813	purine-nucleoside phosphorylase activity
DI487_RS14655	COG0023	Translation Initiation Factor
DI487_RS14665	COG0022	dehydrogenase e1 component
DI487_RS14725	COG0590	tRNA wobble adenosine to inosine editing
DI487_RS14745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI487_RS14755	COG5002	protein histidine kinase activity
DI487_RS14760	COG0745	RESPONSE REGULATOR receiver
DI487_RS14770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DI487_RS14780	COG0484	heat shock protein binding
DI487_RS14800	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DI487_RS14805	COG1028	Short-chain dehydrogenase reductase Sdr
DI487_RS14810	COG1904	glucuronate isomerase
DI487_RS14825	COG0800	Aldolase
DI487_RS14835	COG0246	Mannitol dehydrogenase
DI487_RS14840	COG2721	sulfolactate sulfo-lyase activity
DI487_RS14845	COG1609	Transcriptional regulator
DI487_RS14855	COG4771	TonB-dependent receptor
DI487_RS14875	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DI487_RS14885	COG2755	lipolytic protein G-D-S-L family
DI487_RS14890	COG0657	acetylesterase activity
DI487_RS14890	COG2755	lipolytic protein G-D-S-L family
DI487_RS14915	COG0300	oxidoreductase activity
DI487_RS14950	COG0668	transmembrane transport
DI487_RS14955	COG1607	acyl-coa hydrolase
DI487_RS14970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DI487_RS14970	COG0140	phosphoribosyl-ATP diphosphatase activity
DI487_RS14975	COG0107	imidazoleglycerol-phosphate synthase activity
DI487_RS14980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DI487_RS14990	COG0131	Imidazoleglycerol-phosphate dehydratase
DI487_RS14995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DI487_RS15000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DI487_RS15005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DI487_RS15025	COG5002	protein histidine kinase activity
DI487_RS15030	COG0745	RESPONSE REGULATOR receiver
DI487_RS15050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI487_RS15065	COG1368	sulfuric ester hydrolase activity
DI487_RS15075	COG1028	Short-chain dehydrogenase reductase Sdr
DI487_RS15080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DI487_RS15090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DI487_RS15095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DI487_RS15100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DI487_RS15100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DI487_RS15105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DI487_RS15110	COG1078	dGTPase activity
DI487_RS15120	COG2204	response regulator
DI487_RS15125	COG0802	atpase or kinase
DI487_RS15135	COG0686	Belongs to the AlaDH PNT family
DI487_RS15160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DI487_RS15185	COG1522	sequence-specific DNA binding
DI487_RS15200	COG1162	GTPase activity
DI487_RS15220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DI487_RS15280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DI487_RS15300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DI487_RS15320	COG2885	chlorophyll binding
DI487_RS15330	COG0259	pyridoxamine-phosphate oxidase activity
DI487_RS15340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DI487_RS15350	COG2270	Major facilitator Superfamily
DI487_RS15370	COG0101	tRNA pseudouridine synthase activity
DI487_RS15380	COG1132	(ABC) transporter
DI487_RS15385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DI487_RS15445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI487_RS15490	COG3291	Pkd domain containing protein
DI487_RS15505	COG1959	2 iron, 2 sulfur cluster binding
DI487_RS15550	COG1538	Outer membrane efflux protein
DI487_RS15560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DI487_RS15570	COG3279	Response regulator of the LytR AlgR family
DI487_RS15575	COG3275	phosphorelay sensor kinase activity
DI487_RS15585	COG1136	(ABC) transporter
DI487_RS15590	COG1136	(ABC) transporter
DI487_RS15590	COG0577	efflux transmembrane transporter activity
DI487_RS15610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DI487_RS15615	COG0009	L-threonylcarbamoyladenylate synthase
DI487_RS15635	COG0308	aminopeptidase N
DI487_RS15655	COG2192	nodulation
DI487_RS15660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DI487_RS15665	COG3781	membrane
DI487_RS15675	COG1309	transcriptional regulator
DI487_RS15695	COG1012	belongs to the aldehyde dehydrogenase family
DI487_RS15710	COG0574	Belongs to the PEP-utilizing enzyme family
DI487_RS15710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DI487_RS15715	COG0429	hydrolase of the alpha beta-hydrolase fold
DI487_RS15720	COG2996	Protein conserved in bacteria
DI487_RS15730	COG2264	protein methyltransferase activity
DI487_RS15765	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DI487_RS15835	COG0596	Alpha beta hydrolase
DI487_RS15840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DI487_RS15875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB