locus-tag	class	description
FK004_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK004_RS00025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FK004_RS00035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FK004_RS00040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FK004_RS00045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FK004_RS00050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FK004_RS00065	COG0714	Associated with various cellular activities
FK004_RS00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK004_RS00085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FK004_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FK004_RS00105	COG0085	RNA polymerase activity
FK004_RS00110	COG0222	ribosome binding
FK004_RS00115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FK004_RS00120	COG0081	regulation of translation
FK004_RS00125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FK004_RS00145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FK004_RS00170	COG4974	Belongs to the 'phage' integrase family
FK004_RS00175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FK004_RS00190	COG0366	Alpha amylase catalytic
FK004_RS00195	COG1960	acyl-CoA dehydrogenase activity
FK004_RS00200	COG1555	photosystem II stabilization
FK004_RS00200	COG1596	polysaccharide export
FK004_RS00240	COG4206	TonB-dependent receptor
FK004_RS00240	COG1629	transport
FK004_RS00245	COG1404	Belongs to the peptidase S8 family
FK004_RS00265	COG4771	TonB-dependent receptor
FK004_RS00270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FK004_RS00275	COG0321	lipoyl(octanoyl) transferase activity
FK004_RS00280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FK004_RS00300	COG1858	cytochrome C peroxidase
FK004_RS00325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FK004_RS00330	COG1388	LysM domain
FK004_RS00330	COG0791	NLP P60 protein
FK004_RS00335	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FK004_RS00350	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FK004_RS00370	COG3186	Phenylalanine-4-hydroxylase
FK004_RS00400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FK004_RS00410	COG0739	heme binding
FK004_RS00420	COG1704	LemA family
FK004_RS00430	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FK004_RS00455	COG1160	GTP binding
FK004_RS00465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FK004_RS00510	COG1484	DNA-dependent DNA replication
FK004_RS00515	COG2390	Transcriptional regulator
FK004_RS00515	COG4584	PFAM Integrase catalytic
FK004_RS00535	COG0484	heat shock protein binding
FK004_RS00550	COG1597	lipid kinase activity
FK004_RS00565	COG0488	(ABC) transporter
FK004_RS00595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK004_RS00615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FK004_RS00640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FK004_RS00645	COG0459	protein refolding
FK004_RS00655	COG1301	dicarboxylic acid transport
FK004_RS00670	COG0659	secondary active sulfate transmembrane transporter activity
FK004_RS00675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK004_RS00680	COG3002	Belongs to the UPF0753 family
FK004_RS00710	COG0551	DNA topoisomerase type I activity
FK004_RS00710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FK004_RS00750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FK004_RS00805	COG4584	PFAM Integrase catalytic
FK004_RS00805	COG2390	Transcriptional regulator
FK004_RS00810	COG1484	DNA-dependent DNA replication
FK004_RS00815	COG2390	Transcriptional regulator
FK004_RS00815	COG4584	PFAM Integrase catalytic
FK004_RS00820	COG1484	DNA-dependent DNA replication
FK004_RS00825	COG1074	ATP-dependent DNA helicase activity
FK004_RS00990	COG4974	Belongs to the 'phage' integrase family
FK004_RS01030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FK004_RS01035	COG1185	polyribonucleotide nucleotidyltransferase activity
FK004_RS01055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FK004_RS01060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK004_RS01110	COG3228	Belongs to the MtfA family
FK004_RS01120	COG1610	YqeY-like protein
FK004_RS01125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FK004_RS01140	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK004_RS01145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FK004_RS01150	COG0772	Belongs to the SEDS family
FK004_RS01155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FK004_RS01160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FK004_RS01165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FK004_RS01180	COG0275	rRNA processing
FK004_RS01185	COG2001	Belongs to the MraZ family
FK004_RS01195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FK004_RS01210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FK004_RS01220	COG0358	DNA primase activity
FK004_RS01245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FK004_RS01255	COG0671	phosphoesterase, PA-phosphatase related
FK004_RS01260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FK004_RS01295	COG3340	Belongs to the peptidase S51 family
FK004_RS01315	COG2989	Protein conserved in bacteria
FK004_RS01325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FK004_RS01350	COG2967	ApaG domain
FK004_RS01360	COG1201	RNA secondary structure unwinding
FK004_RS01365	COG1793	dna ligase
FK004_RS01370	COG1793	dna ligase
FK004_RS01370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FK004_RS01375	COG1012	belongs to the aldehyde dehydrogenase family
FK004_RS01380	COG0357	Ribosomal RNA small subunit methyltransferase G
FK004_RS01385	COG3239	Fatty acid desaturase
FK004_RS01390	COG0436	Aminotransferase
FK004_RS01395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FK004_RS01400	COG0745	RESPONSE REGULATOR receiver
FK004_RS01405	COG5002	protein histidine kinase activity
FK004_RS01415	COG3781	membrane
FK004_RS01425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FK004_RS01430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FK004_RS01450	COG4717	serine-type aminopeptidase activity
FK004_RS01475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FK004_RS01485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK004_RS01490	COG1428	Deoxynucleoside kinase
FK004_RS01495	COG0616	signal peptide processing
FK004_RS01515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FK004_RS01525	COG0544	peptidyl-prolyl cis-trans isomerase activity
FK004_RS01530	COG1950	PFAM Membrane protein of
FK004_RS01550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FK004_RS01560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FK004_RS01570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FK004_RS01590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FK004_RS01595	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FK004_RS01615	COG1331	Highly conserved protein containing a thioredoxin domain
FK004_RS01620	COG0668	transmembrane transport
FK004_RS01630	COG1214	PFAM Peptidase M22, glycoprotease
FK004_RS01650	COG0577	efflux transmembrane transporter activity
FK004_RS01650	COG1136	(ABC) transporter
FK004_RS01655	COG0577	efflux transmembrane transporter activity
FK004_RS01655	COG1136	(ABC) transporter
FK004_RS01660	COG1136	(ABC) transporter
FK004_RS01675	COG2322	membrane
FK004_RS01680	COG1999	signal sequence binding
FK004_RS01700	COG1845	cytochrome c oxidase, subunit III
FK004_RS01705	COG0109	protoheme IX farnesyltransferase activity
FK004_RS01715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FK004_RS01725	COG0509	glycine decarboxylation via glycine cleavage system
FK004_RS01735	COG0632	four-way junction helicase activity
FK004_RS01745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FK004_RS01750	COG2255	four-way junction helicase activity
FK004_RS01765	COG0531	amino acid
FK004_RS01775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FK004_RS01780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FK004_RS01805	COG0437	4 iron, 4 sulfur cluster binding
FK004_RS01825	COG4584	PFAM Integrase catalytic
FK004_RS01825	COG2390	Transcriptional regulator
FK004_RS01830	COG1484	DNA-dependent DNA replication
FK004_RS01840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FK004_RS01845	COG0195	Participates in both transcription termination and antitermination
FK004_RS01845	COG2251	uridine kinase activity
FK004_RS01850	COG0779	Required for maturation of 30S ribosomal subunits
FK004_RS01885	COG3118	belongs to the thioredoxin family
FK004_RS01900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FK004_RS01900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FK004_RS01910	COG1609	Transcriptional regulator
FK004_RS01930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FK004_RS01935	COG0052	Belongs to the universal ribosomal protein uS2 family
FK004_RS01940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FK004_RS01945	COG0519	Catalyzes the synthesis of GMP from XMP
FK004_RS01950	COG2104	thiamine diphosphate biosynthetic process
FK004_RS01955	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FK004_RS01965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FK004_RS01965	COG0352	thiamine-phosphate diphosphorylase activity
FK004_RS01965	COG0351	phosphomethylpyrimidine kinase
FK004_RS01970	COG0352	thiamine-phosphate diphosphorylase activity
FK004_RS01975	COG2022	thiamine diphosphate biosynthetic process
FK004_RS01985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FK004_RS01990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FK004_RS02000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK004_RS02005	COG3852	Histidine kinase
FK004_RS02015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK004_RS02030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FK004_RS02045	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FK004_RS02055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FK004_RS02080	COG3179	chitinase
FK004_RS02195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FK004_RS02200	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FK004_RS02205	COG0612	Peptidase, M16
FK004_RS02250	COG0776	regulation of translation
FK004_RS02270	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FK004_RS02275	COG2373	Large extracellular alpha-helical protein
FK004_RS02280	COG0590	tRNA wobble adenosine to inosine editing
FK004_RS02285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FK004_RS02295	COG3328	transposase activity
FK004_RS02310	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FK004_RS02325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FK004_RS02325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK004_RS02345	COG2095	MarC family integral membrane protein
FK004_RS02360	COG0793	Belongs to the peptidase S41A family
FK004_RS02380	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FK004_RS02390	COG0527	aspartate kinase activity
FK004_RS02415	COG0667	Aldo Keto reductase
FK004_RS02425	COG2249	NAD(P)H dehydrogenase (quinone) activity
FK004_RS02430	COG0583	DNA-binding transcription factor activity
FK004_RS02440	COG0561	phosphatase activity
FK004_RS02445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FK004_RS02455	COG0494	nUDIX hydrolase
FK004_RS02460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FK004_RS02490	COG0662	Cupin 2, conserved barrel domain protein
FK004_RS02490	COG2207	Transcriptional regulator
FK004_RS02510	COG2217	Heavy metal translocating P-type atpase
FK004_RS02525	COG3275	phosphorelay sensor kinase activity
FK004_RS02535	COG2814	Major facilitator Superfamily
FK004_RS02540	COG0069	glutamate synthase activity
FK004_RS02545	COG0583	DNA-binding transcription factor activity
FK004_RS02550	COG2855	membrane
FK004_RS02555	COG0300	oxidoreductase activity
FK004_RS02580	COG0720	synthase
FK004_RS02600	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK004_RS02625	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FK004_RS02625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FK004_RS02635	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FK004_RS02645	COG1435	thymidine kinase activity
FK004_RS02655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FK004_RS02660	COG1970	mechanosensitive ion channel activity
FK004_RS02665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FK004_RS02685	COG1505	serine-type exopeptidase activity
FK004_RS02735	COG0823	Involved in the tonB-independent uptake of proteins
FK004_RS02735	COG1506	peptidase
FK004_RS02755	COG0439	Biotin carboxylase
FK004_RS02760	COG0511	ligase activity, forming carbon-carbon bonds
FK004_RS02765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FK004_RS02770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FK004_RS02780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FK004_RS02795	COG2323	membrane
FK004_RS02920	COG2310	stress, protein
FK004_RS02940	COG3279	Response regulator of the LytR AlgR family
FK004_RS02945	COG2972	Histidine kinase
FK004_RS02965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FK004_RS03000	COG0519	Catalyzes the synthesis of GMP from XMP
FK004_RS03010	COG2885	chlorophyll binding
FK004_RS03055	COG0346	lactoylglutathione lyase activity
FK004_RS03060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FK004_RS03070	COG0534	Mate efflux family protein
FK004_RS03105	COG0481	GTPase activity
FK004_RS03115	COG1131	(ABC) transporter
FK004_RS03120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FK004_RS03150	COG0423	glycine-tRNA ligase activity
FK004_RS03170	COG1846	Transcriptional regulator
FK004_RS03180	COG1764	response to oxidative stress
FK004_RS03185	COG0778	Nitroreductase
FK004_RS03190	COG3537	Alpha-1,2-mannosidase
FK004_RS03250	COG1404	Belongs to the peptidase S8 family
FK004_RS03300	COG5520	Belongs to the glycosyl hydrolase 30 family
FK004_RS03305	COG0702	epimerase
FK004_RS03310	COG4771	TonB-dependent receptor
FK004_RS03320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FK004_RS03325	COG1053	succinate dehydrogenase
FK004_RS03340	COG0006	proline dipeptidase activity
FK004_RS03360	COG0156	8-amino-7-oxononanoate synthase activity
FK004_RS03365	COG1074	ATP-dependent DNA helicase activity
FK004_RS03385	COG0328	RNA-DNA hybrid ribonuclease activity
FK004_RS03395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK004_RS03400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK004_RS03405	COG0571	ribonuclease III activity
FK004_RS03430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK004_RS03445	COG2954	triphosphatase activity
FK004_RS03450	COG0492	ferredoxin-NADP+ reductase activity
FK004_RS03470	COG1538	Outer membrane efflux protein
FK004_RS03490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FK004_RS03495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FK004_RS03515	COG0166	Belongs to the GPI family
FK004_RS03535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FK004_RS03540	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FK004_RS03545	COG0531	amino acid
FK004_RS03550	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK004_RS03555	COG0322	excinuclease ABC activity
FK004_RS03565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FK004_RS03570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FK004_RS03580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FK004_RS03595	COG4585	Histidine kinase
FK004_RS03635	COG0326	Molecular chaperone. Has ATPase activity
FK004_RS03680	COG2801	Transposase and inactivated derivatives
FK004_RS03690	COG2801	Transposase and inactivated derivatives
FK004_RS03740	COG4584	PFAM Integrase catalytic
FK004_RS03780	COG3387	PFAM Glycoside hydrolase 15-related
FK004_RS03815	COG1733	regulation of RNA biosynthetic process
FK004_RS03825	COG1381	Involved in DNA repair and RecF pathway recombination
FK004_RS03845	COG0626	cystathionine gamma-synthase activity
FK004_RS03860	COG1393	Belongs to the ArsC family
FK004_RS03870	COG0194	GDP metabolic process
FK004_RS03875	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FK004_RS03880	COG1979	alcohol dehydrogenase
FK004_RS03885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FK004_RS03900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FK004_RS03930	COG2304	oxidoreductase activity
FK004_RS03935	COG2304	oxidoreductase activity
FK004_RS03950	COG0714	Associated with various cellular activities
FK004_RS03955	COG4989	oxidoreductase activity
FK004_RS03960	COG4221	oxidoreductase activity
FK004_RS03995	COG1012	belongs to the aldehyde dehydrogenase family
FK004_RS04040	COG1073	alpha beta
FK004_RS04060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FK004_RS04080	COG2151	metal-sulfur cluster biosynthetic enzyme
FK004_RS04085	COG2166	iron-sulfur cluster assembly
FK004_RS04095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FK004_RS04100	COG2390	Transcriptional regulator
FK004_RS04100	COG4584	PFAM Integrase catalytic
FK004_RS04105	COG1484	DNA-dependent DNA replication
FK004_RS04145	COG3328	transposase activity
FK004_RS04170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FK004_RS04175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FK004_RS04180	COG3720	iron ion transport
FK004_RS04210	COG0719	Fe-S assembly protein
FK004_RS04215	COG0396	ATPase activity
FK004_RS04220	COG0719	Fe-S assembly protein
FK004_RS04225	COG0316	Belongs to the HesB IscA family
FK004_RS04230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK004_RS04250	COG0594	ribonuclease P activity
FK004_RS04255	COG0793	Belongs to the peptidase S41A family
FK004_RS04260	COG2885	chlorophyll binding
FK004_RS04270	COG2153	protein acetylation
FK004_RS04280	COG0741	lytic transglycosylase activity
FK004_RS04280	COG1388	LysM domain
FK004_RS04285	COG0126	phosphoglycerate kinase activity
FK004_RS04395	COG0470	DNA polymerase III
FK004_RS04405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FK004_RS04415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK004_RS04425	COG0445	tRNA wobble uridine modification
FK004_RS04430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FK004_RS04440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK004_RS04440	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FK004_RS04490	COG1368	sulfuric ester hydrolase activity
FK004_RS04510	COG0557	exoribonuclease II activity
FK004_RS04520	COG0698	ribose 5-phosphate isomerase
FK004_RS04535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FK004_RS04600	COG0297	glycogen (starch) synthase activity
FK004_RS04600	COG0438	transferase activity, transferring glycosyl groups
FK004_RS04605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK004_RS04615	COG1215	transferase activity, transferring glycosyl groups
FK004_RS04625	COG0151	Belongs to the GarS family
FK004_RS04640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FK004_RS04650	COG0859	PFAM glycosyl transferase family 9
FK004_RS04660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK004_RS04665	COG1695	Transcriptional regulator
FK004_RS04715	COG0356	it plays a direct role in the translocation of protons across the membrane
FK004_RS04720	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FK004_RS04725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FK004_RS04730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FK004_RS04735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FK004_RS04740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FK004_RS04750	COG0756	dUTP diphosphatase activity
FK004_RS04790	COG1607	acyl-coa hydrolase
FK004_RS04800	COG0758	DNA mediated transformation
FK004_RS04805	COG1054	Belongs to the UPF0176 family
FK004_RS04810	COG1774	PSP1 C-terminal conserved region
FK004_RS04820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FK004_RS04825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FK004_RS04835	COG4172	Belongs to the ABC transporter superfamily
FK004_RS04840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FK004_RS04905	COG0113	porphobilinogen synthase activity
FK004_RS04910	COG0408	coproporphyrinogen oxidase activity
FK004_RS04920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FK004_RS04930	COG0181	hydroxymethylbilane synthase activity
FK004_RS04935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FK004_RS04945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FK004_RS04955	COG1981	membrane
FK004_RS04960	COG5000	phosphorelay sensor kinase activity
FK004_RS04965	COG1024	Enoyl-CoA hydratase
FK004_RS04970	COG1418	mRNA catabolic process
FK004_RS04990	COG3590	peptidase
FK004_RS04995	COG1999	signal sequence binding
FK004_RS05025	COG1914	H( )-stimulated, divalent metal cation uptake system
FK004_RS05040	COG4771	TonB-dependent receptor
FK004_RS05050	COG4774	siderophore transport
FK004_RS05065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK004_RS05090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK004_RS05090	COG3153	acetyltransferase
FK004_RS05100	COG0123	including yeast histone deacetylase and acetoin utilization protein
FK004_RS05120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK004_RS05120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK004_RS05130	COG1619	proteins homologs of microcin C7 resistance protein MccF
FK004_RS05135	COG0792	nuclease activity
FK004_RS05145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FK004_RS05155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK004_RS05170	COG0004	ammonium transporteR
FK004_RS05175	COG1902	pentaerythritol trinitrate reductase activity
FK004_RS05190	COG2986	histidine ammonia-lyase
FK004_RS05200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK004_RS05205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK004_RS05215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FK004_RS05215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FK004_RS05250	COG1131	(ABC) transporter
FK004_RS05275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK004_RS05280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK004_RS05290	COG0726	polysaccharide deacetylase
FK004_RS05315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK004_RS05345	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FK004_RS05445	COG1396	sequence-specific DNA binding
FK004_RS05450	COG0587	DNA-directed DNA polymerase activity
FK004_RS05485	COG4584	PFAM Integrase catalytic
FK004_RS05485	COG2390	Transcriptional regulator
FK004_RS05490	COG1484	DNA-dependent DNA replication
FK004_RS05520	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS05690	COG1902	pentaerythritol trinitrate reductase activity
FK004_RS05695	COG0673	inositol 2-dehydrogenase activity
FK004_RS05700	COG0667	Aldo Keto reductase
FK004_RS05710	COG2267	carboxylic ester hydrolase activity
FK004_RS05715	COG2814	Major facilitator Superfamily
FK004_RS05720	COG0667	Aldo Keto reductase
FK004_RS05735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FK004_RS05750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK004_RS05755	COG2239	Acts as a magnesium transporter
FK004_RS05760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK004_RS05765	COG3152	Membrane
FK004_RS05785	COG0708	Exodeoxyribonuclease III
FK004_RS05800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK004_RS05805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FK004_RS05820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FK004_RS05825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FK004_RS05830	COG0297	glycogen (starch) synthase activity
FK004_RS05840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FK004_RS05850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FK004_RS05865	COG3655	Transcriptional regulator
FK004_RS05875	COG0156	8-amino-7-oxononanoate synthase activity
FK004_RS05970	COG1484	DNA-dependent DNA replication
FK004_RS05975	COG4584	PFAM Integrase catalytic
FK004_RS05975	COG2390	Transcriptional regulator
FK004_RS06055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FK004_RS06060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FK004_RS06100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FK004_RS06120	COG1522	sequence-specific DNA binding
FK004_RS06125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FK004_RS06140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK004_RS06145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FK004_RS06150	COG0193	aminoacyl-tRNA hydrolase activity
FK004_RS06170	COG0196	riboflavin kinase activity
FK004_RS06195	COG4974	Belongs to the 'phage' integrase family
FK004_RS06235	COG2390	Transcriptional regulator
FK004_RS06235	COG4584	PFAM Integrase catalytic
FK004_RS06240	COG1484	DNA-dependent DNA replication
FK004_RS06245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK004_RS06255	COG1007	ATP synthesis coupled electron transport
FK004_RS06265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK004_RS06270	COG0713	ATP synthesis coupled electron transport
FK004_RS06280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK004_RS06285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FK004_RS06290	COG1034	ATP synthesis coupled electron transport
FK004_RS06295	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FK004_RS06300	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FK004_RS06305	COG0649	NAD binding
FK004_RS06310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK004_RS06315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK004_RS06320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK004_RS06325	COG1278	Cold shock
FK004_RS06335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FK004_RS06365	COG0142	geranyltranstransferase activity
FK004_RS06390	COG0567	Dehydrogenase, E1 component
FK004_RS06405	COG0084	hydrolase, TatD family'
FK004_RS06415	COG0252	asparaginase activity
FK004_RS06430	COG1846	Transcriptional regulator
FK004_RS06435	COG1673	EVE domain
FK004_RS06445	COG1595	DNA-templated transcription, initiation
FK004_RS06480	COG2267	carboxylic ester hydrolase activity
FK004_RS06500	COG2801	Transposase and inactivated derivatives
FK004_RS06540	COG1484	DNA-dependent DNA replication
FK004_RS06545	COG4584	PFAM Integrase catalytic
FK004_RS06545	COG2390	Transcriptional regulator
FK004_RS06560	COG0671	phosphoesterase, PA-phosphatase related
FK004_RS06580	COG0431	NADPH-dependent FMN reductase
FK004_RS06595	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FK004_RS06600	COG0017	Asparaginyl-tRNA synthetase
FK004_RS06615	COG3279	Response regulator of the LytR AlgR family
FK004_RS06620	COG0475	glutathione-regulated potassium exporter activity
FK004_RS06625	COG2076	Multidrug Resistance protein
FK004_RS06635	COG0233	cytoplasmic translational termination
FK004_RS06640	COG0528	UMP kinase activity
FK004_RS06665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FK004_RS06670	COG1968	undecaprenyl-diphosphatase activity
FK004_RS06680	COG2177	Part of the ABC transporter FtsEX involved in
FK004_RS06685	COG0495	leucyl-tRNA aminoacylation
FK004_RS06695	COG1522	sequence-specific DNA binding
FK004_RS06705	COG2363	Small membrane protein
FK004_RS06710	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FK004_RS06725	COG0463	Glycosyl transferase, family 2
FK004_RS06730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FK004_RS06740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK004_RS06745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FK004_RS06770	COG0745	RESPONSE REGULATOR receiver
FK004_RS06775	COG5002	protein histidine kinase activity
FK004_RS06780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FK004_RS06785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FK004_RS06855	COG0577	efflux transmembrane transporter activity
FK004_RS06855	COG1136	(ABC) transporter
FK004_RS06865	COG0577	efflux transmembrane transporter activity
FK004_RS06875	COG0577	efflux transmembrane transporter activity
FK004_RS06880	COG0577	efflux transmembrane transporter activity
FK004_RS06890	COG0489	protein tyrosine kinase activity
FK004_RS06900	COG0492	ferredoxin-NADP+ reductase activity
FK004_RS06905	COG0633	Ferredoxin
FK004_RS06925	COG3279	Response regulator of the LytR AlgR family
FK004_RS06930	COG3275	phosphorelay sensor kinase activity
FK004_RS06940	COG1960	acyl-CoA dehydrogenase activity
FK004_RS06990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FK004_RS06995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FK004_RS07000	COG0228	four-way junction DNA binding
FK004_RS07020	COG3118	belongs to the thioredoxin family
FK004_RS07040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FK004_RS07040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FK004_RS07065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FK004_RS07075	COG2186	Transcriptional regulator
FK004_RS07080	COG1629	transport
FK004_RS07085	COG0702	epimerase
FK004_RS07105	COG1917	Cupin 2, conserved barrel domain protein
FK004_RS07110	COG2271	Major facilitator Superfamily
FK004_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS07120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK004_RS07125	COG0800	Aldolase
FK004_RS07135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK004_RS07155	COG2315	Protein conserved in bacteria
FK004_RS07165	COG4584	PFAM Integrase catalytic
FK004_RS07165	COG2390	Transcriptional regulator
FK004_RS07170	COG1484	DNA-dependent DNA replication
FK004_RS07320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FK004_RS07330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FK004_RS07340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FK004_RS07345	COG1629	transport
FK004_RS07345	COG4206	TonB-dependent receptor
FK004_RS07360	COG2190	(PTS) system
FK004_RS07360	COG2211	Major facilitator Superfamily
FK004_RS07365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK004_RS07370	COG1554	hydrolase, family 65, central catalytic
FK004_RS07375	COG0366	Alpha amylase catalytic
FK004_RS07380	COG1501	Belongs to the glycosyl hydrolase 31 family
FK004_RS07385	COG0366	Alpha amylase catalytic
FK004_RS07415	COG0584	glycerophosphoryl diester phosphodiesterase
FK004_RS07420	COG2081	HI0933 family
FK004_RS07425	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FK004_RS07445	COG1187	pseudouridine synthase activity
FK004_RS07455	COG0339	signal peptide processing
FK004_RS07480	COG2989	Protein conserved in bacteria
FK004_RS07495	COG1132	(ABC) transporter
FK004_RS07520	COG2217	Heavy metal translocating P-type atpase
FK004_RS07535	COG2132	Multicopper oxidase
FK004_RS07550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FK004_RS07575	COG1253	flavin adenine dinucleotide binding
FK004_RS07580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK004_RS07600	COG1506	peptidase
FK004_RS07600	COG0823	Involved in the tonB-independent uptake of proteins
FK004_RS07605	COG3104	oligopeptide transport
FK004_RS07610	COG3104	oligopeptide transport
FK004_RS07625	COG0658	competence protein
FK004_RS07625	COG2333	competence protein COMEC
FK004_RS07630	COG0791	NLP P60 protein
FK004_RS07635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK004_RS07645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FK004_RS07655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FK004_RS07670	COG0772	Belongs to the SEDS family
FK004_RS07675	COG0768	penicillin binding
FK004_RS07690	COG1077	Cell shape determining protein MreB Mrl
FK004_RS07695	COG0138	bifunctional purine biosynthesis protein purh
FK004_RS07710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FK004_RS07715	COG0191	fructose-bisphosphate aldolase activity
FK004_RS07735	COG2226	methyltransferase
FK004_RS07740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FK004_RS07750	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FK004_RS07760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FK004_RS07775	COG0022	dehydrogenase e1 component
FK004_RS07775	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK004_RS07780	COG4206	TonB-dependent receptor
FK004_RS07780	COG1629	transport
FK004_RS07785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FK004_RS07790	COG1428	Deoxynucleoside kinase
FK004_RS07825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FK004_RS07840	COG1410	methionine synthase
FK004_RS07840	COG0646	methionine synthase
FK004_RS07850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FK004_RS07870	COG0436	Aminotransferase
FK004_RS07875	COG0287	Prephenate dehydrogenase
FK004_RS07880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FK004_RS07885	COG1162	GTPase activity
FK004_RS07890	COG1490	D-aminoacyl-tRNA deacylase activity
FK004_RS07910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FK004_RS07915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FK004_RS07920	COG3844	kynureninase activity
FK004_RS07925	COG0010	Belongs to the arginase family
FK004_RS07935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK004_RS07945	COG0433	COG0433 Predicted ATPase
FK004_RS07950	COG0811	peptide transport
FK004_RS07985	COG0602	queuosine metabolic process
FK004_RS07995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FK004_RS08015	COG3876	Protein conserved in bacteria
FK004_RS08065	COG2204	response regulator
FK004_RS08070	COG5002	protein histidine kinase activity
FK004_RS08070	COG0784	Response regulator, receiver
FK004_RS08075	COG1960	acyl-CoA dehydrogenase activity
FK004_RS08095	COG0285	dihydrofolate synthase activity
FK004_RS08125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FK004_RS08130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK004_RS08145	COG0295	cytidine deaminase activity
FK004_RS08160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FK004_RS08170	COG2234	aminopeptidase activity
FK004_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS08185	COG1127	ABC transporter
FK004_RS08190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FK004_RS08195	COG1215	transferase activity, transferring glycosyl groups
FK004_RS08200	COG1215	transferase activity, transferring glycosyl groups
FK004_RS08210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FK004_RS08220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FK004_RS08220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FK004_RS08235	COG1090	epimerase
FK004_RS08260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FK004_RS08265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FK004_RS08290	COG3655	Transcriptional regulator
FK004_RS08310	COG3321	synthase
FK004_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS08310	COG0604	alcohol dehydrogenase
FK004_RS08325	COG1943	Transposase
FK004_RS08335	COG2814	Major facilitator Superfamily
FK004_RS08340	COG2207	Transcriptional regulator
FK004_RS08360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FK004_RS08390	COG4585	Histidine kinase
FK004_RS08415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK004_RS08435	COG4771	TonB-dependent receptor
FK004_RS08490	COG1301	dicarboxylic acid transport
FK004_RS08500	COG4772	TonB-dependent receptor
FK004_RS08515	COG0563	adenylate kinase activity
FK004_RS08520	COG1253	flavin adenine dinucleotide binding
FK004_RS08525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FK004_RS08535	COG3279	Response regulator of the LytR AlgR family
FK004_RS08560	COG3591	Belongs to the peptidase S1B family
FK004_RS08570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK004_RS08575	COG3738	Protein conserved in bacteria
FK004_RS08580	COG2003	Belongs to the UPF0758 family
FK004_RS08600	COG1011	Hydrolase
FK004_RS08610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FK004_RS08620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK004_RS08630	COG1629	transport
FK004_RS08630	COG4206	TonB-dependent receptor
FK004_RS08640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FK004_RS08645	COG0049	tRNA binding
FK004_RS08650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FK004_RS08655	COG0051	transcription antitermination factor activity, RNA binding
FK004_RS08660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FK004_RS08665	COG0088	Forms part of the polypeptide exit tunnel
FK004_RS08670	COG0089	rRNA binding
FK004_RS08675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FK004_RS08680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FK004_RS08685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FK004_RS08690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FK004_RS08695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FK004_RS08700	COG0255	Belongs to the universal ribosomal protein uL29 family
FK004_RS08705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FK004_RS08710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FK004_RS08715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FK004_RS08720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FK004_RS08725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FK004_RS08730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FK004_RS08735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FK004_RS08740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FK004_RS08745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FK004_RS08750	COG1841	ribosomal large subunit assembly
FK004_RS08755	COG0200	Binds to the 23S rRNA
FK004_RS08760	COG0201	protein transport
FK004_RS08765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FK004_RS08770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FK004_RS08775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FK004_RS08780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FK004_RS08785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FK004_RS08790	COG0202	RNA polymerase activity
FK004_RS08795	COG0203	ribosomal protein L17
FK004_RS08800	COG0505	Belongs to the CarA family
FK004_RS08805	COG0148	phosphopyruvate hydratase activity
FK004_RS08825	COG1959	2 iron, 2 sulfur cluster binding
FK004_RS08835	COG0175	sulfate reduction
FK004_RS08845	COG2895	sulfate adenylyltransferase (ATP) activity
FK004_RS08850	COG2095	MarC family integral membrane protein
FK004_RS08870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK004_RS08875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FK004_RS08885	COG0489	protein tyrosine kinase activity
FK004_RS08895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK004_RS08900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FK004_RS08905	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FK004_RS08960	COG1086	Polysaccharide biosynthesis protein
FK004_RS08975	COG0297	glycogen (starch) synthase activity
FK004_RS08995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FK004_RS09000	COG1086	Polysaccharide biosynthesis protein
FK004_RS09015	COG4464	protein tyrosine phosphatase activity
FK004_RS09025	COG1216	Glycosyl transferase, family 2
FK004_RS09035	COG0463	Glycosyl transferase, family 2
FK004_RS09055	COG0463	Glycosyl transferase, family 2
FK004_RS09055	COG1216	Glycosyl transferase, family 2
FK004_RS09070	COG1083	cytidylyl-transferase
FK004_RS09075	COG2089	acid synthase
FK004_RS09085	COG0726	polysaccharide deacetylase
FK004_RS09095	COG0438	transferase activity, transferring glycosyl groups
FK004_RS09120	COG0438	transferase activity, transferring glycosyl groups
FK004_RS09135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FK004_RS09140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FK004_RS09160	COG1137	ATPase activity
FK004_RS09170	COG0805	protein transport
FK004_RS09175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FK004_RS09175	COG0517	IMP dehydrogenase activity
FK004_RS09180	COG0514	ATP-dependent DNA helicase (RecQ)
FK004_RS09190	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FK004_RS09195	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FK004_RS09205	COG1482	cell wall glycoprotein biosynthetic process
FK004_RS09290	COG3290	protein histidine kinase activity
FK004_RS09305	COG1082	Xylose isomerase domain protein TIM barrel
FK004_RS09315	COG0326	Molecular chaperone. Has ATPase activity
FK004_RS09365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FK004_RS09370	COG1663	tetraacyldisaccharide 4'-kinase activity
FK004_RS09380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FK004_RS09395	COG0018	arginyl-trna synthetase
FK004_RS09405	COG3942	CHAP domain
FK004_RS09405	COG1388	LysM domain
FK004_RS09410	COG1696	Membrane protein involved in D-alanine export
FK004_RS09435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FK004_RS09440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FK004_RS09445	COG2239	Acts as a magnesium transporter
FK004_RS09450	COG1187	pseudouridine synthase activity
FK004_RS09455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FK004_RS09460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FK004_RS09495	COG2808	Putative FMN-binding domain
FK004_RS09500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FK004_RS09510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FK004_RS09520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FK004_RS09525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FK004_RS09550	COG0681	Belongs to the peptidase S26 family
FK004_RS09555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FK004_RS09565	COG1475	DNA binding
FK004_RS09570	COG1192	Involved in chromosome partitioning
FK004_RS09575	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS09615	COG0667	Aldo Keto reductase
FK004_RS09675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FK004_RS09695	COG0025	NhaP-type Na H and K H
FK004_RS09705	COG3831	ATPase activity
FK004_RS09705	COG4884	unkown
FK004_RS09730	COG1690	Belongs to the RtcB family
FK004_RS09735	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FK004_RS09755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK004_RS09755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK004_RS09775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FK004_RS09780	COG1053	succinate dehydrogenase
FK004_RS09790	COG0471	metal ion transport
FK004_RS09835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FK004_RS09860	COG0456	acetyltransferase
FK004_RS09915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FK004_RS09920	COG1484	DNA-dependent DNA replication
FK004_RS09925	COG4584	PFAM Integrase catalytic
FK004_RS09925	COG2390	Transcriptional regulator
FK004_RS09940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FK004_RS09960	COG2267	carboxylic ester hydrolase activity
FK004_RS09965	COG1012	belongs to the aldehyde dehydrogenase family
FK004_RS09970	COG0592	DNA-directed DNA polymerase activity
FK004_RS09995	COG1702	phosphate starvation-inducible protein PhoH
FK004_RS10005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FK004_RS10015	COG1363	Peptidase, m42
FK004_RS10130	COG2195	Cleaves the N-terminal amino acid of tripeptides
FK004_RS10140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FK004_RS10145	COG0284	orotidine-5'-phosphate decarboxylase activity
FK004_RS10150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FK004_RS10160	COG0753	catalase activity
FK004_RS10165	COG2962	Rard protein
FK004_RS10170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK004_RS10170	COG1703	isobutyryl-CoA mutase activity
FK004_RS10170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK004_RS10190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FK004_RS10330	COG0300	oxidoreductase activity
FK004_RS10365	COG3781	membrane
FK004_RS10415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FK004_RS10450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FK004_RS10460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK004_RS10465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK004_RS10465	COG0519	Catalyzes the synthesis of GMP from XMP
FK004_RS10480	COG3530	Putative quorum-sensing-regulated virulence factor
FK004_RS10485	COG0504	CTP synthase activity
FK004_RS10490	COG0706	membrane insertase activity
FK004_RS10500	COG0482	sulfurtransferase activity
FK004_RS10510	COG0626	cystathionine gamma-synthase activity
FK004_RS10535	COG0697	spore germination
FK004_RS10550	COG0288	reversible hydration of carbon dioxide
FK004_RS10575	COG0019	diaminopimelate decarboxylase activity
FK004_RS10580	COG0045	succinate-CoA ligase (ADP-forming) activity
FK004_RS10605	COG0556	nucleotide-excision repair
FK004_RS10615	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FK004_RS10625	COG0335	large ribosomal subunit rRNA binding
FK004_RS10630	COG0336	Belongs to the RNA methyltransferase TrmD family
FK004_RS10640	COG2814	Major facilitator Superfamily
FK004_RS10645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FK004_RS10690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK004_RS10695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK004_RS10700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FK004_RS10700	COG1333	cytochrome c biogenesis protein
FK004_RS10705	COG0386	Belongs to the glutathione peroxidase family
FK004_RS10715	COG1131	(ABC) transporter
FK004_RS10735	COG0346	lactoylglutathione lyase activity
FK004_RS10765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FK004_RS10775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK004_RS10785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FK004_RS10790	COG0735	belongs to the Fur family
FK004_RS10795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK004_RS10810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK004_RS10820	COG0714	Associated with various cellular activities
FK004_RS10845	COG2860	membrane
FK004_RS10885	COG1215	transferase activity, transferring glycosyl groups
FK004_RS10890	COG0438	transferase activity, transferring glycosyl groups
FK004_RS10905	COG2884	Cell division ATP-binding protein ftsE
FK004_RS10920	COG2996	Protein conserved in bacteria
FK004_RS10930	COG3384	dioxygenase
FK004_RS10935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK004_RS10965	COG3428	Bacterial PH domain
FK004_RS10970	COG1575	Belongs to the MenA family. Type 1 subfamily
FK004_RS10975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FK004_RS11000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK004_RS11005	COG0069	glutamate synthase activity
FK004_RS11015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK004_RS11025	COG1132	(ABC) transporter
FK004_RS11035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FK004_RS11045	COG1862	Preprotein translocase
FK004_RS11050	COG2195	Cleaves the N-terminal amino acid of tripeptides
FK004_RS11060	COG0167	dihydroorotate dehydrogenase activity
FK004_RS11100	COG0517	IMP dehydrogenase activity
FK004_RS11100	COG0516	GMP reductase activity
FK004_RS11105	COG4651	solute:proton antiporter activity
FK004_RS11105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FK004_RS11130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK004_RS11150	COG2270	Major facilitator Superfamily
FK004_RS11165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FK004_RS11175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FK004_RS11180	COG2211	Major facilitator Superfamily
FK004_RS11190	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FK004_RS11240	COG3328	transposase activity
FK004_RS11260	COG4771	TonB-dependent receptor
FK004_RS11265	COG1522	sequence-specific DNA binding
FK004_RS11300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK004_RS11315	COG1830	Aldolase
FK004_RS11325	COG1733	regulation of RNA biosynthetic process
FK004_RS11350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK004_RS11355	COG4584	PFAM Integrase catalytic
FK004_RS11355	COG2390	Transcriptional regulator
FK004_RS11360	COG1484	DNA-dependent DNA replication
FK004_RS11365	COG1113	amino acid transport
FK004_RS11385	COG2390	Transcriptional regulator
FK004_RS11385	COG4584	PFAM Integrase catalytic
FK004_RS11390	COG1484	DNA-dependent DNA replication
FK004_RS11525	COG3209	COG3209 Rhs family protein
FK004_RS11535	COG3209	COG3209 Rhs family protein
FK004_RS11550	COG2826	transposase and inactivated derivatives, IS30 family
FK004_RS11555	COG1484	DNA-dependent DNA replication
FK004_RS11565	COG1484	DNA-dependent DNA replication
FK004_RS11570	COG2390	Transcriptional regulator
FK004_RS11570	COG4584	PFAM Integrase catalytic
FK004_RS11600	COG2390	Transcriptional regulator
FK004_RS11600	COG4584	PFAM Integrase catalytic
FK004_RS11605	COG1484	DNA-dependent DNA replication
FK004_RS11610	COG1113	amino acid transport
FK004_RS11630	COG4584	PFAM Integrase catalytic
FK004_RS11630	COG2390	Transcriptional regulator
FK004_RS11635	COG1484	DNA-dependent DNA replication
FK004_RS11685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FK004_RS11710	COG2197	response regulator
FK004_RS11715	COG4585	Histidine kinase
FK004_RS11735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FK004_RS11765	COG1187	pseudouridine synthase activity
FK004_RS11785	COG2201	protein-glutamate methylesterase activity
FK004_RS11795	COG0156	8-amino-7-oxononanoate synthase activity
FK004_RS11850	COG1733	regulation of RNA biosynthetic process
FK004_RS11860	COG1349	DNA-binding transcription factor activity
FK004_RS11865	COG2223	nitrite transmembrane transporter activity
FK004_RS11870	COG1064	alcohol dehydrogenase
FK004_RS11895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK004_RS11900	COG4251	negative regulation of phosphorylation
FK004_RS11930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FK004_RS11985	COG3275	phosphorelay sensor kinase activity
FK004_RS12020	COG1612	heme a metabolic process
FK004_RS12025	COG0617	tRNA 3'-terminal CCA addition
FK004_RS12025	COG0517	IMP dehydrogenase activity
FK004_RS12025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK004_RS12030	COG0009	L-threonylcarbamoyladenylate synthase
FK004_RS12045	COG1216	Glycosyl transferase, family 2
FK004_RS12055	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FK004_RS12060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK004_RS12065	COG1216	Glycosyl transferase, family 2
FK004_RS12085	COG0726	polysaccharide deacetylase
FK004_RS12095	COG0463	Glycosyl transferase, family 2
FK004_RS12110	COG2171	N-acyltransferase activity
FK004_RS12120	COG0693	protein deglycase activity
FK004_RS12125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK004_RS12135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FK004_RS12135	COG0047	phosphoribosylformylglycinamidine synthase activity
FK004_RS12150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FK004_RS12165	COG3422	double-strand break repair
FK004_RS12175	COG2234	aminopeptidase activity
FK004_RS12210	COG3871	stress protein (general stress protein 26)
FK004_RS12215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK004_RS12220	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FK004_RS12245	COG1271	oxidase subunit
FK004_RS12275	COG1472	Belongs to the glycosyl hydrolase 3 family
FK004_RS12290	COG0300	oxidoreductase activity
FK004_RS12320	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK004_RS12325	COG2197	response regulator
FK004_RS12420	COG2390	Transcriptional regulator
FK004_RS12420	COG4584	PFAM Integrase catalytic
FK004_RS12425	COG1484	DNA-dependent DNA replication
FK004_RS12510	COG3328	transposase activity
FK004_RS12515	COG1484	DNA-dependent DNA replication
FK004_RS12520	COG4584	PFAM Integrase catalytic
FK004_RS12520	COG2390	Transcriptional regulator
FK004_RS12660	COG2885	chlorophyll binding
FK004_RS12675	COG2390	Transcriptional regulator
FK004_RS12675	COG4584	PFAM Integrase catalytic
FK004_RS12680	COG1484	DNA-dependent DNA replication
FK004_RS12685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK004_RS12685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK004_RS12690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK004_RS12710	COG0583	DNA-binding transcription factor activity
FK004_RS12755	COG4221	oxidoreductase activity
FK004_RS12765	COG4251	negative regulation of phosphorylation
FK004_RS12775	COG1335	isochorismatase
FK004_RS12780	COG1335	isochorismatase
FK004_RS12800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FK004_RS12800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FK004_RS12815	COG1674	ftsk spoiiie
FK004_RS12835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK004_RS12840	COG0450	alkyl hydroperoxide reductase
FK004_RS12845	COG0531	amino acid
FK004_RS12850	COG0823	Involved in the tonB-independent uptake of proteins
FK004_RS12850	COG1506	peptidase
FK004_RS12855	COG0626	cystathionine gamma-synthase activity
FK004_RS12860	COG1522	sequence-specific DNA binding
FK004_RS12865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FK004_RS12870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK004_RS12885	COG0037	tRNA processing
FK004_RS12890	COG4232	protein-disulfide reductase activity
FK004_RS12895	COG3457	Alanine racemase
FK004_RS12905	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK004_RS12945	COG1607	acyl-coa hydrolase
FK004_RS12950	COG0668	transmembrane transport
FK004_RS12955	COG2814	Major facilitator Superfamily
FK004_RS12960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FK004_RS12995	COG3278	Belongs to the heme-copper respiratory oxidase family
FK004_RS13010	COG0348	domain, Protein
FK004_RS13030	COG2205	protein histidine kinase activity
FK004_RS13040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FK004_RS13055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FK004_RS13070	COG1309	transcriptional regulator
FK004_RS13075	COG0300	oxidoreductase activity
FK004_RS13085	COG2204	response regulator
FK004_RS13090	COG1760	l-serine dehydratase
FK004_RS13095	COG2342	PFAM TM1410 hypothetical-related protein
FK004_RS13100	COG0443	Heat shock 70 kDa protein
FK004_RS13105	COG0657	acetylesterase activity
FK004_RS13150	COG0300	oxidoreductase activity
FK004_RS13155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FK004_RS13165	COG0488	(ABC) transporter
FK004_RS13175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FK004_RS13180	COG0540	Belongs to the ATCase OTCase family
FK004_RS13195	COG1234	tRNA 3'-trailer cleavage
FK004_RS13200	COG0259	pyridoxamine-phosphate oxidase activity
FK004_RS13210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FK004_RS13245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FK004_RS13250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK004_RS13255	COG0640	Transcriptional regulator
FK004_RS13265	COG0798	PFAM Bile acid sodium symporter
FK004_RS13275	COG1733	regulation of RNA biosynthetic process
FK004_RS13310	COG2390	Transcriptional regulator
FK004_RS13310	COG4584	PFAM Integrase catalytic
FK004_RS13315	COG1484	DNA-dependent DNA replication
FK004_RS13335	COG0686	Belongs to the AlaDH PNT family
FK004_RS13340	COG0802	atpase or kinase
FK004_RS13345	COG2204	response regulator
FK004_RS13355	COG1078	dGTPase activity
FK004_RS13360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK004_RS13365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FK004_RS13365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK004_RS13370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK004_RS13375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FK004_RS13380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK004_RS13400	COG1741	Belongs to the pirin family
FK004_RS13440	COG2310	stress, protein
FK004_RS13530	COG0488	(ABC) transporter
FK004_RS13540	COG0513	Belongs to the DEAD box helicase family
FK004_RS13550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK004_RS13565	COG0745	RESPONSE REGULATOR receiver
FK004_RS13570	COG0010	Belongs to the arginase family
FK004_RS13590	COG1228	amidohydrolase
FK004_RS13595	COG0598	Magnesium transport protein CorA
FK004_RS13615	COG1393	Belongs to the ArsC family
FK004_RS13620	COG1266	CAAX protease self-immunity
FK004_RS13640	COG0038	chloride channel
FK004_RS13645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FK004_RS13650	COG3425	synthase
FK004_RS13680	COG2321	neutral zinc metallopeptidase
FK004_RS13715	COG3409	Peptidoglycan-binding domain 1 protein
FK004_RS13715	COG0793	Belongs to the peptidase S41A family
FK004_RS13725	COG1733	regulation of RNA biosynthetic process
FK004_RS13735	COG0604	alcohol dehydrogenase
FK004_RS13740	COG1733	regulation of RNA biosynthetic process
FK004_RS13745	COG1335	isochorismatase
FK004_RS13765	COG1132	(ABC) transporter
FK004_RS13835	COG2801	Transposase and inactivated derivatives
FK004_RS13870	COG1484	DNA-dependent DNA replication
FK004_RS13875	COG2390	Transcriptional regulator
FK004_RS13875	COG4584	PFAM Integrase catalytic
FK004_RS13885	COG3158	transport of potassium into the cell
FK004_RS13890	COG3781	membrane
FK004_RS13900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FK004_RS13935	COG0009	L-threonylcarbamoyladenylate synthase
FK004_RS13945	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS13955	COG1368	sulfuric ester hydrolase activity
FK004_RS13970	COG0259	pyridoxamine-phosphate oxidase activity
FK004_RS13975	COG0745	RESPONSE REGULATOR receiver
FK004_RS13980	COG5002	protein histidine kinase activity
FK004_RS13985	COG0564	pseudouridine synthase activity
FK004_RS13990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FK004_RS13995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK004_RS14010	COG0494	nUDIX hydrolase
FK004_RS14040	COG0579	oxidoreductase
FK004_RS14070	COG2801	Transposase and inactivated derivatives
FK004_RS14075	COG2801	Transposase and inactivated derivatives
FK004_RS14085	COG2801	Transposase and inactivated derivatives
FK004_RS14145	COG4221	oxidoreductase activity
FK004_RS14150	COG0745	RESPONSE REGULATOR receiver
FK004_RS14155	COG5002	protein histidine kinase activity
FK004_RS14180	COG0745	RESPONSE REGULATOR receiver
FK004_RS14195	COG0477	Major facilitator Superfamily
FK004_RS14205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FK004_RS14215	COG0306	phosphate transporter
FK004_RS14230	COG4191	Histidine kinase
FK004_RS14245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FK004_RS14250	COG1770	oligopeptidase
FK004_RS14265	COG0217	transcriptional regulatory protein
FK004_RS14270	COG0793	Belongs to the peptidase S41A family
FK004_RS14275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FK004_RS14285	COG0083	homoserine kinase activity
FK004_RS14290	COG0527	aspartate kinase activity
FK004_RS14290	COG0460	homoserine dehydrogenase
FK004_RS14295	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FK004_RS14305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK004_RS14310	COG2986	histidine ammonia-lyase
FK004_RS14315	COG2323	membrane
FK004_RS14320	COG0189	ligase activity
FK004_RS14320	COG4067	protein conserved in archaea
FK004_RS14330	COG0542	response to heat
FK004_RS14335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FK004_RS14365	COG1252	NADH dehydrogenase
FK004_RS14435	COG0628	permease
FK004_RS14445	COG2176	DNA-directed DNA polymerase activity
FK004_RS14470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FK004_RS14475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FK004_RS14490	COG2378	regulation of single-species biofilm formation
FK004_RS14500	COG1349	DNA-binding transcription factor activity
FK004_RS14505	COG2807	transmembrane transport
FK004_RS14580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK004_RS14595	COG0745	RESPONSE REGULATOR receiver
FK004_RS14640	COG0022	dehydrogenase e1 component
FK004_RS14655	COG0813	purine-nucleoside phosphorylase activity
FK004_RS14675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FK004_RS14685	COG3011	Protein conserved in bacteria
FK004_RS14700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FK004_RS14705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK004_RS14730	COG0438	transferase activity, transferring glycosyl groups
FK004_RS14740	COG1472	Belongs to the glycosyl hydrolase 3 family
FK004_RS14750	COG2181	nitrate reductase activity
FK004_RS14750	COG0247	lactate metabolic process
FK004_RS14760	COG2181	nitrate reductase activity
FK004_RS14760	COG0247	lactate metabolic process
FK004_RS14765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FK004_RS14770	COG1388	LysM domain
FK004_RS14770	COG0860	N-Acetylmuramoyl-L-alanine amidase
FK004_RS14780	COG0251	oxidation-reduction process
FK004_RS14785	COG1803	Methylglyoxal synthase
FK004_RS14800	COG0205	6-phosphofructokinase activity
FK004_RS14810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FK004_RS14880	COG2239	Acts as a magnesium transporter
FK004_RS14885	COG1285	pathogenesis
FK004_RS14895	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS14900	COG0183	Belongs to the thiolase family
FK004_RS14905	COG0791	NLP P60 protein
FK004_RS14915	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FK004_RS14920	COG1285	pathogenesis
FK004_RS14995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FK004_RS15035	COG2814	Major facilitator Superfamily
FK004_RS15070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK004_RS15095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FK004_RS15120	COG0137	argininosuccinate synthase activity
FK004_RS15125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FK004_RS15130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK004_RS15140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FK004_RS15145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FK004_RS15150	COG0165	Argininosuccinate lyase
FK004_RS15155	COG2814	Major facilitator Superfamily
FK004_RS15165	COG0542	response to heat
FK004_RS15175	COG3781	membrane
FK004_RS15190	COG1484	DNA-dependent DNA replication
FK004_RS15195	COG2390	Transcriptional regulator
FK004_RS15195	COG4584	PFAM Integrase catalytic
FK004_RS15220	COG4584	PFAM Integrase catalytic
FK004_RS15220	COG2390	Transcriptional regulator
FK004_RS15225	COG1484	DNA-dependent DNA replication
FK004_RS15250	COG0702	epimerase
FK004_RS15260	COG0644	oxidoreductase
FK004_RS15265	COG0657	acetylesterase activity
FK004_RS15265	COG2755	lipolytic protein G-D-S-L family
FK004_RS15270	COG0644	oxidoreductase
FK004_RS15285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK004_RS15295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK004_RS15310	COG0730	response to heat
FK004_RS15315	COG2186	Transcriptional regulator
FK004_RS15320	COG1132	(ABC) transporter
FK004_RS15325	COG1132	(ABC) transporter
FK004_RS15330	COG5002	protein histidine kinase activity
FK004_RS15330	COG0784	Response regulator, receiver
FK004_RS15340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FK004_RS15375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FK004_RS15380	COG4999	Histidine kinase
FK004_RS15380	COG3850	Histidine kinase
FK004_RS15380	COG3437	response regulator, receiver
FK004_RS15380	COG2205	protein histidine kinase activity
FK004_RS15385	COG0784	Response regulator, receiver
FK004_RS15385	COG2205	protein histidine kinase activity
FK004_RS15390	COG4251	negative regulation of phosphorylation
FK004_RS15395	COG3279	Response regulator of the LytR AlgR family
FK004_RS15400	COG3537	Alpha-1,2-mannosidase
FK004_RS15405	COG1027	Aspartate ammonia-lyase
FK004_RS15410	COG0252	asparaginase activity
FK004_RS15435	COG0519	Catalyzes the synthesis of GMP from XMP
FK004_RS15455	COG0531	amino acid
FK004_RS15460	COG0697	spore germination
FK004_RS15470	COG0583	DNA-binding transcription factor activity
FK004_RS15475	COG1764	response to oxidative stress
FK004_RS15480	COG0598	Magnesium transport protein CorA
FK004_RS15500	COG1733	regulation of RNA biosynthetic process
FK004_RS15505	COG4335	DNA alkylation repair
FK004_RS15510	COG3012	SEC-C Motif Domain Protein
FK004_RS15525	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS15530	COG1104	cysteine desulfurase activity
FK004_RS15540	COG1082	Xylose isomerase domain protein TIM barrel
FK004_RS15570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK004_RS15585	COG1764	response to oxidative stress
FK004_RS15590	COG2205	protein histidine kinase activity
FK004_RS15595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FK004_RS15615	COG0116	Belongs to the methyltransferase superfamily
FK004_RS15615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FK004_RS15640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FK004_RS15665	COG0861	Integral membrane protein TerC family
FK004_RS15705	COG0237	dephospho-CoA kinase activity
FK004_RS15725	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FK004_RS15730	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FK004_RS15735	COG0497	DNA recombination
FK004_RS15760	COG1528	Iron-storage protein
FK004_RS15765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FK004_RS15780	COG0737	Belongs to the 5'-nucleotidase family
FK004_RS15785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FK004_RS15795	COG0359	binds to the 23S rRNA
FK004_RS15800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FK004_RS15805	COG0360	Binds together with S18 to 16S ribosomal RNA
FK004_RS15810	COG3279	Response regulator of the LytR AlgR family
FK004_RS15815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FK004_RS15825	COG1295	ribonuclease BN
FK004_RS15845	COG0237	dephospho-CoA kinase activity
FK004_RS15845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FK004_RS15855	COG0531	amino acid
FK004_RS15875	COG0424	maF-like protein
FK004_RS15885	COG0628	permease
FK004_RS15910	COG0415	Belongs to the DNA photolyase family
FK004_RS15915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK004_RS15920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK004_RS15925	COG1595	DNA-templated transcription, initiation
FK004_RS15955	COG2076	Multidrug Resistance protein
FK004_RS15965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FK004_RS15965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FK004_RS15985	COG0101	tRNA pseudouridine synthase activity
FK004_RS15990	COG1132	(ABC) transporter
FK004_RS15995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK004_RS16000	COG0366	Alpha amylase catalytic
FK004_RS16005	COG0596	Alpha beta hydrolase
FK004_RS16020	COG1404	Belongs to the peptidase S8 family
FK004_RS16030	COG3842	ATPase activity
FK004_RS16040	COG4628	conserved protein (DUF2132)
FK004_RS16045	COG3047	cAMP biosynthetic process
FK004_RS16050	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FK004_RS16055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FK004_RS16060	COG0673	inositol 2-dehydrogenase activity
FK004_RS16065	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK004_RS16075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FK004_RS16080	COG2176	DNA-directed DNA polymerase activity
FK004_RS16085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK004_RS16090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FK004_RS16100	COG0012	GTP binding
FK004_RS16110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK004_RS16120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FK004_RS16125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK004_RS16145	COG2234	aminopeptidase activity
FK004_RS16155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK004_RS16160	COG1136	(ABC) transporter
FK004_RS16215	COG0513	Belongs to the DEAD box helicase family
FK004_RS16225	COG2706	6-phosphogluconolactonase activity
FK004_RS16235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FK004_RS16270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FK004_RS16275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FK004_RS16280	COG1595	DNA-templated transcription, initiation
FK004_RS16285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK004_RS16290	COG3956	TIGRFAM MazG family protein
FK004_RS16300	COG0242	peptide deformylase activity
FK004_RS16305	COG1289	transmembrane transporter activity
FK004_RS16310	COG0579	oxidoreductase
FK004_RS16315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FK004_RS16320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FK004_RS16325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FK004_RS16345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK004_RS16350	COG0149	triose-phosphate isomerase activity
FK004_RS16360	COG2264	protein methyltransferase activity
FK004_RS16375	COG1629	transport
FK004_RS16380	COG0702	epimerase
FK004_RS16420	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FK004_RS16460	COG4452	Inner membrane protein CreD
FK004_RS16480	COG1472	Belongs to the glycosyl hydrolase 3 family
FK004_RS16485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FK004_RS16485	COG5479	isomerase activity
FK004_RS16495	COG0702	epimerase
FK004_RS16500	COG4771	TonB-dependent receptor
FK004_RS16535	COG0024	Methionine aminopeptidase
FK004_RS16560	COG2378	regulation of single-species biofilm formation
FK004_RS16625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK004_RS16635	COG1012	belongs to the aldehyde dehydrogenase family
FK004_RS16665	COG1484	DNA-dependent DNA replication
FK004_RS16670	COG2390	Transcriptional regulator
FK004_RS16670	COG4584	PFAM Integrase catalytic
FK004_RS16675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FK004_RS16690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK004_RS16695	COG1846	Transcriptional regulator
FK004_RS16700	COG0778	Nitroreductase
FK004_RS16715	COG1045	serine acetyltransferase
FK004_RS16720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FK004_RS16725	COG0512	Glutamine amidotransferase of anthranilate synthase
FK004_RS16725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FK004_RS16730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FK004_RS16735	COG0134	indole-3-glycerol-phosphate synthase activity
FK004_RS16740	COG0135	phosphoribosylanthranilate isomerase activity
FK004_RS16745	COG0133	tryptophan synthase activity
FK004_RS16750	COG0159	tryptophan synthase activity
FK004_RS16755	COG1309	transcriptional regulator
FK004_RS16770	COG2814	Major facilitator Superfamily
FK004_RS16785	COG3022	response to hydroperoxide
FK004_RS16790	COG0564	pseudouridine synthase activity
FK004_RS16805	COG1181	Belongs to the D-alanine--D-alanine ligase family
FK004_RS16810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FK004_RS16815	COG0513	Belongs to the DEAD box helicase family
FK004_RS16825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FK004_RS16840	COG0799	negative regulation of ribosome biogenesis
FK004_RS16845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK004_RS16855	COG4589	Belongs to the CDS family
FK004_RS16860	COG0688	phosphatidylethanolamine metabolic process
FK004_RS16880	COG0525	valine-tRNA ligase activity
FK004_RS16895	COG0436	Aminotransferase
FK004_RS16910	COG0302	gtp cyclohydrolase
FK004_RS16915	COG0215	cysteine-tRNA ligase activity
FK004_RS16920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FK004_RS16925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FK004_RS16930	COG1484	DNA-dependent DNA replication
FK004_RS16935	COG4584	PFAM Integrase catalytic
FK004_RS16935	COG2390	Transcriptional regulator
FK004_RS16940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FK004_RS16945	COG0039	L-malate dehydrogenase activity
FK004_RS16950	COG0187	DNA topoisomerase II activity
FK004_RS16955	COG0367	asparagine synthase
FK004_RS16960	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FK004_RS16965	COG1247	-acetyltransferase
FK004_RS16970	COG1217	gtp-binding protein TYPA
FK004_RS16975	COG5002	protein histidine kinase activity
FK004_RS16980	COG2201	protein-glutamate methylesterase activity
FK004_RS16985	COG0268	Binds directly to 16S ribosomal RNA
FK004_RS17000	COG0442	prolyl-tRNA aminoacylation
FK004_RS17015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FK004_RS17025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FK004_RS17030	COG3345	alpha-galactosidase
FK004_RS17040	COG0561	phosphatase activity
FK004_RS17050	COG2169	Transcriptional regulator
FK004_RS17055	COG4124	Belongs to the glycosyl hydrolase 26 family
FK004_RS17060	COG2211	Major facilitator Superfamily
FK004_RS17065	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FK004_RS17070	COG2942	2-epimerase
FK004_RS17085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FK004_RS17090	COG1607	acyl-coa hydrolase
FK004_RS17100	COG2814	Major facilitator Superfamily
FK004_RS17105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK004_RS17110	COG1733	regulation of RNA biosynthetic process
FK004_RS17135	COG2755	lipolytic protein G-D-S-L family
FK004_RS17150	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FK004_RS17155	COG0105	UTP biosynthetic process
FK004_RS17170	COG0552	protein localization to endoplasmic reticulum
FK004_RS17180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FK004_RS17185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FK004_RS17190	COG1058	Belongs to the CinA family
FK004_RS17190	COG1546	Belongs to the CinA family
FK004_RS17200	COG0179	Fumarylacetoacetate (FAA) hydrolase
FK004_RS17210	COG1690	Belongs to the RtcB family
FK004_RS17225	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK004_RS17240	COG0488	(ABC) transporter
FK004_RS17250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK004_RS17255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FK004_RS17275	COG1136	(ABC) transporter
FK004_RS17290	COG0653	protein targeting
FK004_RS17305	COG0277	FAD linked oxidase domain protein
FK004_RS17315	COG2353	YceI-like domain
FK004_RS17320	COG2223	nitrite transmembrane transporter activity
FK004_RS17325	COG1959	2 iron, 2 sulfur cluster binding
FK004_RS17350	COG0534	Mate efflux family protein
FK004_RS17360	COG2326	polyphosphate kinase activity
FK004_RS17380	COG2304	oxidoreductase activity
FK004_RS17390	COG0488	(ABC) transporter
FK004_RS17410	COG2204	response regulator
FK004_RS17420	COG4152	abc transporter atp-binding protein
FK004_RS17425	COG0484	heat shock protein binding
FK004_RS17430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FK004_RS17480	COG0492	ferredoxin-NADP+ reductase activity
FK004_RS17490	COG4974	Belongs to the 'phage' integrase family
FK004_RS17515	COG4584	PFAM Integrase catalytic
FK004_RS17515	COG2390	Transcriptional regulator
FK004_RS17520	COG1484	DNA-dependent DNA replication
FK004_RS17550	COG1629	transport
FK004_RS17560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FK004_RS17570	COG2197	response regulator
FK004_RS17575	COG1611	Belongs to the LOG family
FK004_RS17585	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FK004_RS17620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FK004_RS17640	COG0514	ATP-dependent DNA helicase (RecQ)
FK004_RS17650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FK004_RS17655	COG1522	sequence-specific DNA binding
FK004_RS17680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FK004_RS17725	COG2249	NAD(P)H dehydrogenase (quinone) activity
FK004_RS17730	COG0667	Aldo Keto reductase
FK004_RS17770	COG1484	DNA-dependent DNA replication
FK004_RS17775	COG4584	PFAM Integrase catalytic
FK004_RS17775	COG2390	Transcriptional regulator
FK004_RS17820	COG0659	secondary active sulfate transmembrane transporter activity
FK004_RS17835	COG0492	ferredoxin-NADP+ reductase activity
FK004_RS17835	COG3118	belongs to the thioredoxin family
FK004_RS17845	COG3685	Protein conserved in bacteria
FK004_RS17860	COG1741	Belongs to the pirin family
FK004_RS17865	COG2353	YceI-like domain
FK004_RS17875	COG0561	phosphatase activity
FK004_RS17905	COG3279	Response regulator of the LytR AlgR family
FK004_RS17910	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FK004_RS17925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK004_RS17925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FK004_RS17930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK004_RS17950	COG1560	Kdo2-lipid A biosynthetic process
FK004_RS17970	COG0242	peptide deformylase activity
FK004_RS17975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK004_RS17985	COG0038	chloride channel
FK004_RS17990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK004_RS17995	COG1611	Belongs to the LOG family
FK004_RS18000	COG2356	endonuclease I
FK004_RS18010	COG0022	dehydrogenase e1 component
FK004_RS18015	COG1917	Cupin 2, conserved barrel domain protein
FK004_RS18015	COG2207	Transcriptional regulator
FK004_RS18025	COG1012	belongs to the aldehyde dehydrogenase family
FK004_RS18030	COG1022	Amp-dependent synthetase and ligase
FK004_RS18035	COG1846	Transcriptional regulator
FK004_RS18040	COG1024	Enoyl-CoA hydratase
FK004_RS18040	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK004_RS18045	COG0183	Belongs to the thiolase family
FK004_RS18050	COG1960	acyl-CoA dehydrogenase activity
FK004_RS18070	COG4251	negative regulation of phosphorylation
FK004_RS18090	COG0288	reversible hydration of carbon dioxide
FK004_RS18095	COG0659	secondary active sulfate transmembrane transporter activity
FK004_RS18105	COG0783	Belongs to the Dps family
FK004_RS18130	COG0753	catalase activity
FK004_RS18135	COG1028	Short-chain dehydrogenase reductase Sdr
FK004_RS18145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FK004_RS18165	COG1595	DNA-templated transcription, initiation
FK004_RS18175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FK004_RS18180	COG1960	acyl-CoA dehydrogenase activity
FK004_RS18275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FK004_RS18280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FK004_RS18285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FK004_RS18290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FK004_RS18300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FK004_RS18310	COG0300	oxidoreductase activity
FK004_RS18315	COG1446	asparaginase
FK004_RS18320	COG4242	Belongs to the peptidase S51 family
FK004_RS18325	COG0189	ligase activity
FK004_RS18325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FK004_RS18335	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FK004_RS18340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FK004_RS18345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FK004_RS18350	COG0131	Imidazoleglycerol-phosphate dehydratase
FK004_RS18355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FK004_RS18360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FK004_RS18365	COG0107	imidazoleglycerol-phosphate synthase activity
FK004_RS18370	COG0140	phosphoribosyl-ATP diphosphatase activity
FK004_RS18370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FK004_RS18385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FK004_RS18405	COG0305	Participates in initiation and elongation during chromosome replication
FK004_RS18410	COG0825	malonyl-CoA metabolic process
FK004_RS18425	COG0343	queuine tRNA-ribosyltransferase activity
FK004_RS18440	COG3959	Transketolase, thiamine diphosphate binding domain
FK004_RS18445	COG3958	Transketolase
FK004_RS18450	COG0545	Peptidyl-prolyl cis-trans isomerase
FK004_RS18455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FK004_RS18460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FK004_RS18465	COG3361	conserved protein (COG2071)
FK004_RS18470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FK004_RS18510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK004_RS18520	COG0604	alcohol dehydrogenase
FK004_RS18540	COG1902	pentaerythritol trinitrate reductase activity
FK004_RS18545	COG1733	regulation of RNA biosynthetic process
FK004_RS18555	COG2192	nodulation
FK004_RS18625	COG1233	COG1233 Phytoene dehydrogenase and related
FK004_RS18670	COG4206	TonB-dependent receptor
FK004_RS18680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FK004_RS18685	COG1120	ATPase activity
FK004_RS18730	COG1607	acyl-coa hydrolase
FK004_RS18740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FK004_RS18745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FK004_RS18765	COG1741	Belongs to the pirin family
FK004_RS18780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FK004_RS18790	COG0745	RESPONSE REGULATOR receiver
FK004_RS18795	COG5002	protein histidine kinase activity
FK004_RS18810	COG0254	rRNA binding
FK004_RS18820	COG0463	Glycosyl transferase, family 2
FK004_RS18825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK004_RS18830	COG1132	(ABC) transporter
FK004_RS18850	COG0739	heme binding
FK004_RS18870	COG1418	mRNA catabolic process
FK004_RS18875	COG0784	Response regulator, receiver
FK004_RS18875	COG2198	Histidine kinase
FK004_RS18875	COG0643	Histidine kinase
FK004_RS18905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FK004_RS18915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FK004_RS18935	COG0514	ATP-dependent DNA helicase (RecQ)
FK004_RS18940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FK004_RS18950	COG1678	Uncharacterized ACR, COG1678
FK004_RS18975	COG0596	Alpha beta hydrolase
FK004_RS18990	COG2814	Major facilitator Superfamily
FK004_RS19020	COG1484	DNA-dependent DNA replication
FK004_RS19025	COG4584	PFAM Integrase catalytic
FK004_RS19025	COG2390	Transcriptional regulator
FK004_RS19080	COG0124	histidyl-tRNA synthetase
FK004_RS19090	COG0577	efflux transmembrane transporter activity
FK004_RS19090	COG1136	(ABC) transporter
FK004_RS19095	COG2890	protein-(glutamine-N5) methyltransferase activity
FK004_RS19100	COG0456	acetyltransferase
FK004_RS19105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK004_RS19105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK004_RS19115	COG1739	Uncharacterized protein family UPF0029
FK004_RS19120	COG0824	Thioesterase