locus-tag	class	description
HYN56_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYN56_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYN56_RS00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYN56_RS00025	COG0436	Aminotransferase
HYN56_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS00045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN56_RS00060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN56_RS00060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN56_RS00070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYN56_RS00075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYN56_RS00080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYN56_RS00095	COG0686	Belongs to the AlaDH PNT family
HYN56_RS00100	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
HYN56_RS00135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYN56_RS00140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HYN56_RS00145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYN56_RS00150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYN56_RS00160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYN56_RS00220	COG0825	malonyl-CoA metabolic process
HYN56_RS00235	COG0343	queuine tRNA-ribosyltransferase activity
HYN56_RS00245	COG3959	Transketolase, thiamine diphosphate binding domain
HYN56_RS00250	COG3958	Transketolase
HYN56_RS00255	COG0545	Peptidyl-prolyl cis-trans isomerase
HYN56_RS00265	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYN56_RS00270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYN56_RS00320	COG1233	COG1233 Phytoene dehydrogenase and related
HYN56_RS00340	COG0415	Belongs to the DNA photolyase family
HYN56_RS00345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYN56_RS00355	COG1090	epimerase
HYN56_RS00370	COG1607	acyl-coa hydrolase
HYN56_RS00425	COG1187	pseudouridine synthase activity
HYN56_RS00435	COG1120	ATPase activity
HYN56_RS00445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYN56_RS00460	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HYN56_RS00465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HYN56_RS00475	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HYN56_RS00485	COG4206	TonB-dependent receptor
HYN56_RS00520	COG4682	membrane
HYN56_RS00525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYN56_RS00530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYN56_RS00555	COG0471	metal ion transport
HYN56_RS00565	COG0488	(ABC) transporter
HYN56_RS00580	COG0254	rRNA binding
HYN56_RS00595	COG0463	Glycosyl transferase, family 2
HYN56_RS00600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYN56_RS00605	COG1132	(ABC) transporter
HYN56_RS00625	COG0739	heme binding
HYN56_RS00640	COG1418	mRNA catabolic process
HYN56_RS00650	COG4974	Belongs to the 'phage' integrase family
HYN56_RS00675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYN56_RS00680	COG4771	TonB-dependent receptor
HYN56_RS00685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYN56_RS00690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYN56_RS00720	COG0514	ATP-dependent DNA helicase (RecQ)
HYN56_RS00725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYN56_RS00735	COG1678	Uncharacterized ACR, COG1678
HYN56_RS00760	COG3177	Filamentation induced by cAMP protein fic
HYN56_RS00775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYN56_RS00825	COG3550	peptidyl-serine autophosphorylation
HYN56_RS00840	COG3250	beta-galactosidase activity
HYN56_RS00865	COG1629	transport
HYN56_RS00870	COG3292	Two component regulator propeller
HYN56_RS00870	COG0745	RESPONSE REGULATOR receiver
HYN56_RS00870	COG2205	protein histidine kinase activity
HYN56_RS00895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYN56_RS00925	COG0702	epimerase
HYN56_RS00930	COG4771	TonB-dependent receptor
HYN56_RS00935	COG2814	Major facilitator Superfamily
HYN56_RS00960	COG2217	Heavy metal translocating P-type atpase
HYN56_RS00965	COG2132	Multicopper oxidase
HYN56_RS01030	COG1192	Involved in chromosome partitioning
HYN56_RS01035	COG1475	DNA binding
HYN56_RS01045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYN56_RS01075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYN56_RS01080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYN56_RS01090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYN56_RS01110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYN56_RS01115	COG2808	Putative FMN-binding domain
HYN56_RS01140	COG0501	Belongs to the peptidase M48B family
HYN56_RS01145	COG0501	Belongs to the peptidase M48B family
HYN56_RS01150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYN56_RS01160	COG0784	Response regulator, receiver
HYN56_RS01160	COG2198	Histidine kinase
HYN56_RS01160	COG2205	protein histidine kinase activity
HYN56_RS01165	COG1663	tetraacyldisaccharide 4'-kinase activity
HYN56_RS01180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYN56_RS01200	COG1187	pseudouridine synthase activity
HYN56_RS01230	COG0598	Magnesium transport protein CorA
HYN56_RS01235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYN56_RS01240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYN56_RS01245	COG1696	Membrane protein involved in D-alanine export
HYN56_RS01250	COG3942	CHAP domain
HYN56_RS01250	COG1388	LysM domain
HYN56_RS01265	COG4771	TonB-dependent receptor
HYN56_RS01280	COG4771	TonB-dependent receptor
HYN56_RS01290	COG0018	arginyl-trna synthetase
HYN56_RS01300	COG3142	Participates in the control of copper homeostasis
HYN56_RS01305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYN56_RS01310	COG3842	ATPase activity
HYN56_RS01330	COG2885	chlorophyll binding
HYN56_RS01340	COG0326	Molecular chaperone. Has ATPase activity
HYN56_RS01380	COG1482	cell wall glycoprotein biosynthetic process
HYN56_RS01385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYN56_RS01395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HYN56_RS01400	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN56_RS01405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN56_RS01425	COG1309	transcriptional regulator
HYN56_RS01435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS01440	COG1131	(ABC) transporter
HYN56_RS01445	COG1131	(ABC) transporter
HYN56_RS01450	COG0842	Transport permease protein
HYN56_RS01455	COG0842	Transport permease protein
HYN56_RS01460	COG0006	proline dipeptidase activity
HYN56_RS01480	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HYN56_RS01495	COG0514	ATP-dependent DNA helicase (RecQ)
HYN56_RS01500	COG0517	IMP dehydrogenase activity
HYN56_RS01500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HYN56_RS01505	COG0805	protein transport
HYN56_RS01510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYN56_RS01515	COG1137	ATPase activity
HYN56_RS01525	COG1183	phosphatidylcholine synthase activity
HYN56_RS01540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYN56_RS01570	COG0297	glycogen (starch) synthase activity
HYN56_RS01570	COG0438	transferase activity, transferring glycosyl groups
HYN56_RS01615	COG2089	acid synthase
HYN56_RS01620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HYN56_RS01665	COG2226	methyltransferase
HYN56_RS01670	COG0463	Glycosyl transferase, family 2
HYN56_RS01670	COG1216	Glycosyl transferase, family 2
HYN56_RS01685	COG3754	Rhamnan synthesis protein F
HYN56_RS01695	COG0110	maltose O-acetyltransferase activity
HYN56_RS01730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYN56_RS01745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN56_RS01750	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HYN56_RS01755	COG1090	epimerase
HYN56_RS01775	COG1215	transferase activity, transferring glycosyl groups
HYN56_RS01780	COG1216	Glycosyl transferase, family 2
HYN56_RS01785	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HYN56_RS01790	COG0438	transferase activity, transferring glycosyl groups
HYN56_RS01815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN56_RS01825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYN56_RS01850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HYN56_RS01860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYN56_RS01865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN56_RS01870	COG3206	protein involved in exopolysaccharide biosynthesis
HYN56_RS01870	COG0489	protein tyrosine kinase activity
HYN56_RS01880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYN56_RS01890	COG2095	MarC family integral membrane protein
HYN56_RS01910	COG0148	phosphopyruvate hydratase activity
HYN56_RS01915	COG0505	Belongs to the CarA family
HYN56_RS01920	COG0203	ribosomal protein L17
HYN56_RS01925	COG0202	RNA polymerase activity
HYN56_RS01930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYN56_RS01935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYN56_RS01940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYN56_RS01945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYN56_RS01950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYN56_RS01955	COG0201	protein transport
HYN56_RS01960	COG0200	Binds to the 23S rRNA
HYN56_RS01965	COG1841	ribosomal large subunit assembly
HYN56_RS01970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYN56_RS01975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYN56_RS01980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYN56_RS01985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYN56_RS01990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYN56_RS01995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYN56_RS02000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYN56_RS02005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYN56_RS02010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYN56_RS02015	COG0255	Belongs to the universal ribosomal protein uL29 family
HYN56_RS02020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYN56_RS02025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYN56_RS02030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYN56_RS02035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYN56_RS02040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYN56_RS02045	COG0089	rRNA binding
HYN56_RS02050	COG0088	Forms part of the polypeptide exit tunnel
HYN56_RS02055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYN56_RS02060	COG0051	transcription antitermination factor activity, RNA binding
HYN56_RS02065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYN56_RS02070	COG0049	tRNA binding
HYN56_RS02075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYN56_RS02085	COG4206	TonB-dependent receptor
HYN56_RS02085	COG1629	transport
HYN56_RS02105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYN56_RS02125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYN56_RS02135	COG1011	Hydrolase
HYN56_RS02140	COG2003	Belongs to the UPF0758 family
HYN56_RS02150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYN56_RS02160	COG3591	Belongs to the peptidase S1B family
HYN56_RS02165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYN56_RS02170	COG1253	flavin adenine dinucleotide binding
HYN56_RS02175	COG0563	adenylate kinase activity
HYN56_RS02180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYN56_RS02190	COG4772	TonB-dependent receptor
HYN56_RS02200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYN56_RS02215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYN56_RS02235	COG2949	membrane
HYN56_RS02245	COG1510	regulation of RNA biosynthetic process
HYN56_RS02265	COG1090	epimerase
HYN56_RS02280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYN56_RS02280	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYN56_RS02295	COG1215	transferase activity, transferring glycosyl groups
HYN56_RS02300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYN56_RS02305	COG1127	ABC transporter
HYN56_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS02325	COG1960	acyl-CoA dehydrogenase activity
HYN56_RS02350	COG0848	biopolymer transport protein
HYN56_RS02355	COG0811	peptide transport
HYN56_RS02360	COG0285	dihydrofolate synthase activity
HYN56_RS02390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYN56_RS02410	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HYN56_RS02470	COG2318	DinB family
HYN56_RS02475	COG0602	queuosine metabolic process
HYN56_RS02495	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HYN56_RS02500	COG0848	biopolymer transport protein
HYN56_RS02515	COG0433	COG0433 Predicted ATPase
HYN56_RS02520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYN56_RS02555	COG2366	antibiotic biosynthetic process
HYN56_RS02575	COG3844	kynureninase activity
HYN56_RS02580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYN56_RS02610	COG1490	D-aminoacyl-tRNA deacylase activity
HYN56_RS02615	COG1162	GTPase activity
HYN56_RS02620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HYN56_RS02630	COG0436	Aminotransferase
HYN56_RS02635	COG0077	Prephenate dehydratase
HYN56_RS02670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYN56_RS02670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYN56_RS02685	COG2095	MarC family integral membrane protein
HYN56_RS02710	COG0793	Belongs to the peptidase S41A family
HYN56_RS02730	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HYN56_RS02740	COG0527	aspartate kinase activity
HYN56_RS02810	COG5002	protein histidine kinase activity
HYN56_RS02820	COG4771	TonB-dependent receptor
HYN56_RS02840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYN56_RS02845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYN56_RS02855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYN56_RS02860	COG0463	Glycosyl transferase, family 2
HYN56_RS02875	COG1522	sequence-specific DNA binding
HYN56_RS02885	COG2197	response regulator
HYN56_RS02890	COG4585	Histidine kinase
HYN56_RS02915	COG0495	leucyl-tRNA aminoacylation
HYN56_RS02925	COG2177	Part of the ABC transporter FtsEX involved in
HYN56_RS02935	COG1968	undecaprenyl-diphosphatase activity
HYN56_RS02940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYN56_RS02960	COG0528	UMP kinase activity
HYN56_RS02965	COG0233	cytoplasmic translational termination
HYN56_RS02975	COG0475	glutathione-regulated potassium exporter activity
HYN56_RS02980	COG3279	Response regulator of the LytR AlgR family
HYN56_RS02995	COG0017	Asparaginyl-tRNA synthetase
HYN56_RS03015	COG1435	thymidine kinase activity
HYN56_RS03025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYN56_RS03035	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYN56_RS03035	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYN56_RS03040	COG2211	Major facilitator Superfamily
HYN56_RS03060	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN56_RS03065	COG0720	synthase
HYN56_RS03070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HYN56_RS03150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYN56_RS03160	COG0823	Involved in the tonB-independent uptake of proteins
HYN56_RS03160	COG1506	peptidase
HYN56_RS03165	COG0784	Response regulator, receiver
HYN56_RS03165	COG2205	protein histidine kinase activity
HYN56_RS03200	COG0439	Biotin carboxylase
HYN56_RS03205	COG0511	ligase activity, forming carbon-carbon bonds
HYN56_RS03210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYN56_RS03215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYN56_RS03225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYN56_RS03245	COG0346	lactoylglutathione lyase activity
HYN56_RS03290	COG1349	DNA-binding transcription factor activity
HYN56_RS03295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYN56_RS03300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYN56_RS03310	COG1053	succinate dehydrogenase
HYN56_RS03320	COG3425	synthase
HYN56_RS03370	COG0456	acetyltransferase
HYN56_RS03370	COG1214	PFAM Peptidase M22, glycoprotease
HYN56_RS03400	COG0006	proline dipeptidase activity
HYN56_RS03425	COG1629	transport
HYN56_RS03440	COG2267	carboxylic ester hydrolase activity
HYN56_RS03460	COG2885	chlorophyll binding
HYN56_RS03470	COG1074	ATP-dependent DNA helicase activity
HYN56_RS03475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYN56_RS03500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYN56_RS03505	COG1381	Involved in DNA repair and RecF pathway recombination
HYN56_RS03525	COG0626	cystathionine gamma-synthase activity
HYN56_RS03540	COG4221	oxidoreductase activity
HYN56_RS03545	COG4989	oxidoreductase activity
HYN56_RS03550	COG0714	Associated with various cellular activities
HYN56_RS03565	COG2304	oxidoreductase activity
HYN56_RS03570	COG2304	oxidoreductase activity
HYN56_RS03595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYN56_RS03605	COG0322	excinuclease ABC activity
HYN56_RS03615	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYN56_RS03620	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HYN56_RS03625	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HYN56_RS03635	COG3483	tryptophan 2,3-dioxygenase activity
HYN56_RS03665	COG0166	Belongs to the GPI family
HYN56_RS03680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYN56_RS03690	COG1393	Belongs to the ArsC family
HYN56_RS03695	COG1561	YicC-like family, N-terminal region
HYN56_RS03700	COG0194	GDP metabolic process
HYN56_RS03705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYN56_RS03710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYN56_RS03735	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HYN56_RS03760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYN56_RS03775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYN56_RS03780	COG1056	cytidyltransferase-related domain
HYN56_RS03780	COG1051	belongs to the nudix hydrolase family
HYN56_RS03800	COG1979	alcohol dehydrogenase
HYN56_RS03810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYN56_RS03820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYN56_RS03850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HYN56_RS03855	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS03865	COG1082	Xylose isomerase domain protein TIM barrel
HYN56_RS03870	COG1501	Belongs to the glycosyl hydrolase 31 family
HYN56_RS03875	COG3250	beta-galactosidase activity
HYN56_RS03885	COG0702	epimerase
HYN56_RS03890	COG4771	TonB-dependent receptor
HYN56_RS03905	COG0481	GTPase activity
HYN56_RS03915	COG2378	regulation of single-species biofilm formation
HYN56_RS03920	COG2318	DinB family
HYN56_RS03935	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HYN56_RS03955	COG3279	Response regulator of the LytR AlgR family
HYN56_RS03960	COG0423	glycine-tRNA ligase activity
HYN56_RS03965	COG1040	competence protein
HYN56_RS03975	COG0196	riboflavin kinase activity
HYN56_RS03985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYN56_RS04025	COG1595	DNA-templated transcription, initiation
HYN56_RS04040	COG0156	8-amino-7-oxononanoate synthase activity
HYN56_RS04050	COG3655	Transcriptional regulator
HYN56_RS04065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYN56_RS04080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYN56_RS04090	COG0297	glycogen (starch) synthase activity
HYN56_RS04095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYN56_RS04100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HYN56_RS04110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYN56_RS04115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYN56_RS04120	COG3279	Response regulator of the LytR AlgR family
HYN56_RS04125	COG2972	Histidine kinase
HYN56_RS04145	COG0667	Aldo Keto reductase
HYN56_RS04155	COG0708	Exodeoxyribonuclease III
HYN56_RS04180	COG3152	Membrane
HYN56_RS04185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYN56_RS04195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYN56_RS04205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYN56_RS04210	COG2239	Acts as a magnesium transporter
HYN56_RS04215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYN56_RS04230	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYN56_RS04235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYN56_RS04265	COG3507	Belongs to the glycosyl hydrolase 43 family
HYN56_RS04270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYN56_RS04270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYN56_RS04290	COG2268	Band 7 protein
HYN56_RS04320	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HYN56_RS04320	COG2885	chlorophyll binding
HYN56_RS04330	COG1528	Iron-storage protein
HYN56_RS04345	COG0629	single-stranded DNA binding
HYN56_RS04350	COG3153	acetyltransferase
HYN56_RS04350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYN56_RS04370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN56_RS04390	COG0700	Nucleoside recognition
HYN56_RS04415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYN56_RS04440	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYN56_RS04445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HYN56_RS04455	COG1774	PSP1 C-terminal conserved region
HYN56_RS04530	COG4804	nuclease activity
HYN56_RS04585	COG0826	peptidase U32
HYN56_RS04600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS04610	COG1538	Outer membrane efflux protein
HYN56_RS04635	COG0297	glycogen (starch) synthase activity
HYN56_RS04655	COG4771	TonB-dependent receptor
HYN56_RS04660	COG0492	ferredoxin-NADP+ reductase activity
HYN56_RS04675	COG1914	H( )-stimulated, divalent metal cation uptake system
HYN56_RS04680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYN56_RS04680	COG1321	iron dependent repressor
HYN56_RS04695	COG1024	Enoyl-CoA hydratase
HYN56_RS04700	COG5000	phosphorelay sensor kinase activity
HYN56_RS04705	COG1981	membrane
HYN56_RS04715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYN56_RS04725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYN56_RS04730	COG0181	hydroxymethylbilane synthase activity
HYN56_RS04735	COG4804	nuclease activity
HYN56_RS04745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYN56_RS04770	COG0408	coproporphyrinogen oxidase activity
HYN56_RS04780	COG3588	fructose-bisphosphate aldolase
HYN56_RS04795	COG0113	porphobilinogen synthase activity
HYN56_RS04805	COG3590	peptidase
HYN56_RS04810	COG3590	peptidase
HYN56_RS04815	COG1999	signal sequence binding
HYN56_RS04840	COG1418	mRNA catabolic process
HYN56_RS04855	COG0594	ribonuclease P activity
HYN56_RS04865	COG0793	Belongs to the peptidase S41A family
HYN56_RS04900	COG1388	LysM domain
HYN56_RS04900	COG1705	Flagellar rod assembly protein muramidase FlgJ
HYN56_RS04905	COG0126	phosphoglycerate kinase activity
HYN56_RS04930	COG3279	Response regulator of the LytR AlgR family
HYN56_RS04935	COG3275	phosphorelay sensor kinase activity
HYN56_RS04975	COG0470	DNA polymerase III
HYN56_RS04985	COG1607	acyl-coa hydrolase
HYN56_RS04990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYN56_RS05010	COG0180	Tryptophanyl-tRNA synthetase
HYN56_RS05015	COG0758	DNA mediated transformation
HYN56_RS05030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYN56_RS05050	COG0445	tRNA wobble uridine modification
HYN56_RS05060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYN56_RS05070	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HYN56_RS05070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYN56_RS05100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYN56_RS05130	COG0557	exoribonuclease II activity
HYN56_RS05150	COG0698	ribose 5-phosphate isomerase
HYN56_RS05210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYN56_RS05275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYN56_RS05280	COG1215	transferase activity, transferring glycosyl groups
HYN56_RS05305	COG0151	Belongs to the GarS family
HYN56_RS05320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYN56_RS05330	COG0859	PFAM glycosyl transferase family 9
HYN56_RS05355	COG4152	abc transporter atp-binding protein
HYN56_RS05380	COG0356	it plays a direct role in the translocation of protons across the membrane
HYN56_RS05385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYN56_RS05390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYN56_RS05395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYN56_RS05400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYN56_RS05405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYN56_RS05420	COG0756	dUTP diphosphatase activity
HYN56_RS05425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYN56_RS05450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYN56_RS05460	COG0534	Mate efflux family protein
HYN56_RS05465	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYN56_RS05475	COG4115	mRNA cleavage
HYN56_RS05485	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HYN56_RS05515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYN56_RS05555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYN56_RS05560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYN56_RS05570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYN56_RS05575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYN56_RS05585	COG0842	Transport permease protein
HYN56_RS05590	COG1131	(ABC) transporter
HYN56_RS05620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYN56_RS05635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYN56_RS05640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYN56_RS05645	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS05675	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYN56_RS05680	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS05685	COG2721	sulfolactate sulfo-lyase activity
HYN56_RS05690	COG2207	Transcriptional regulator
HYN56_RS05705	COG1085	galactose-1-phosphate uridylyltransferase
HYN56_RS05710	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYN56_RS05745	COG1069	ribulokinase activity
HYN56_RS05755	COG2160	L-arabinose isomerase activity
HYN56_RS05775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYN56_RS05780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYN56_RS05785	COG0193	aminoacyl-tRNA hydrolase activity
HYN56_RS05815	COG1595	DNA-templated transcription, initiation
HYN56_RS05825	COG0328	RNA-DNA hybrid ribonuclease activity
HYN56_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYN56_RS05840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYN56_RS05845	COG0571	ribonuclease III activity
HYN56_RS05860	COG3119	arylsulfatase activity
HYN56_RS05970	COG1902	pentaerythritol trinitrate reductase activity
HYN56_RS05975	COG0673	inositol 2-dehydrogenase activity
HYN56_RS06000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYN56_RS06025	COG2151	metal-sulfur cluster biosynthetic enzyme
HYN56_RS06035	COG2166	iron-sulfur cluster assembly
HYN56_RS06045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYN56_RS06055	COG0719	Fe-S assembly protein
HYN56_RS06060	COG0396	ATPase activity
HYN56_RS06075	COG0719	Fe-S assembly protein
HYN56_RS06080	COG0316	Belongs to the HesB IscA family
HYN56_RS06090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYN56_RS06105	COG1404	Belongs to the peptidase S8 family
HYN56_RS06115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN56_RS06125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYN56_RS06150	COG0792	nuclease activity
HYN56_RS06155	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYN56_RS06190	COG1012	belongs to the aldehyde dehydrogenase family
HYN56_RS06225	COG1007	ATP synthesis coupled electron transport
HYN56_RS06230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN56_RS06235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYN56_RS06240	COG0713	ATP synthesis coupled electron transport
HYN56_RS06245	COG0839	Belongs to the complex I subunit 6 family
HYN56_RS06250	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN56_RS06255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYN56_RS06260	COG1034	ATP synthesis coupled electron transport
HYN56_RS06270	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HYN56_RS06275	COG0649	NAD binding
HYN56_RS06280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN56_RS06285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN56_RS06290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN56_RS06295	COG1278	Cold shock
HYN56_RS06300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYN56_RS06305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS06345	COG0567	Dehydrogenase, E1 component
HYN56_RS06440	COG0084	hydrolase, TatD family'
HYN56_RS06450	COG0252	asparaginase activity
HYN56_RS06460	COG0583	DNA-binding transcription factor activity
HYN56_RS06545	COG1960	acyl-CoA dehydrogenase activity
HYN56_RS06625	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYN56_RS06635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYN56_RS06640	COG0228	four-way junction DNA binding
HYN56_RS06665	COG0066	3-isopropylmalate dehydratase activity
HYN56_RS06670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYN56_RS06675	COG1917	Cupin 2, conserved barrel domain protein
HYN56_RS06675	COG4977	sequence-specific DNA binding
HYN56_RS06680	COG0300	oxidoreductase activity
HYN56_RS06695	COG0673	inositol 2-dehydrogenase activity
HYN56_RS06700	COG1505	serine-type exopeptidase activity
HYN56_RS06705	COG4771	TonB-dependent receptor
HYN56_RS06725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYN56_RS06730	COG1970	mechanosensitive ion channel activity
HYN56_RS06735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYN56_RS06760	COG0489	protein tyrosine kinase activity
HYN56_RS06770	COG0577	efflux transmembrane transporter activity
HYN56_RS06775	COG1136	(ABC) transporter
HYN56_RS06775	COG0577	efflux transmembrane transporter activity
HYN56_RS06805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYN56_RS06810	COG0004	ammonium transporteR
HYN56_RS06835	COG1401	restriction endodeoxyribonuclease activity
HYN56_RS06865	COG3279	Response regulator of the LytR AlgR family
HYN56_RS06885	COG4206	TonB-dependent receptor
HYN56_RS06925	COG4977	sequence-specific DNA binding
HYN56_RS06925	COG1917	Cupin 2, conserved barrel domain protein
HYN56_RS06950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYN56_RS07035	COG2363	Small membrane protein
HYN56_RS07040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HYN56_RS07090	COG2315	Protein conserved in bacteria
HYN56_RS07115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYN56_RS07125	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYN56_RS07160	COG1187	pseudouridine synthase activity
HYN56_RS07195	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HYN56_RS07220	COG0546	phosphoglycolate phosphatase activity
HYN56_RS07225	COG2081	HI0933 family
HYN56_RS07230	COG0584	glycerophosphoryl diester phosphodiesterase
HYN56_RS07235	COG0366	Alpha amylase catalytic
HYN56_RS07240	COG0366	Alpha amylase catalytic
HYN56_RS07250	COG1082	Xylose isomerase domain protein TIM barrel
HYN56_RS07255	COG1554	hydrolase, family 65, central catalytic
HYN56_RS07260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYN56_RS07275	COG4206	TonB-dependent receptor
HYN56_RS07275	COG1629	transport
HYN56_RS07280	COG0702	epimerase
HYN56_RS07320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYN56_RS07340	COG4536	flavin adenine dinucleotide binding
HYN56_RS07345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYN56_RS07365	COG1506	peptidase
HYN56_RS07365	COG0823	Involved in the tonB-independent uptake of proteins
HYN56_RS07375	COG3104	oligopeptide transport
HYN56_RS07380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS07395	COG2333	competence protein COMEC
HYN56_RS07395	COG0658	competence protein
HYN56_RS07400	COG0791	NLP P60 protein
HYN56_RS07405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN56_RS07415	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HYN56_RS07430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYN56_RS07435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYN56_RS07450	COG2205	protein histidine kinase activity
HYN56_RS07485	COG3239	Fatty acid desaturase
HYN56_RS07490	COG1185	polyribonucleotide nucleotidyltransferase activity
HYN56_RS07495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYN56_RS07545	COG0772	Belongs to the SEDS family
HYN56_RS07550	COG0768	penicillin binding
HYN56_RS07570	COG0138	bifunctional purine biosynthesis protein purh
HYN56_RS07585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYN56_RS07610	COG2226	methyltransferase
HYN56_RS07615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYN56_RS07630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HYN56_RS07640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYN56_RS07645	COG2086	electron transfer activity
HYN56_RS07650	COG0022	dehydrogenase e1 component
HYN56_RS07650	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYN56_RS07660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYN56_RS07665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYN56_RS07670	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HYN56_RS07685	COG1428	Deoxynucleoside kinase
HYN56_RS07710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYN56_RS07725	COG0460	homoserine dehydrogenase
HYN56_RS07725	COG0527	aspartate kinase activity
HYN56_RS07740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYN56_RS07745	COG0527	aspartate kinase activity
HYN56_RS07745	COG0460	homoserine dehydrogenase
HYN56_RS07750	COG1765	OsmC-like protein
HYN56_RS07765	COG1959	2 iron, 2 sulfur cluster binding
HYN56_RS07770	COG0730	response to heat
HYN56_RS07775	COG0730	response to heat
HYN56_RS07785	COG0175	sulfate reduction
HYN56_RS07795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYN56_RS07800	COG1648	precorrin-2 dehydrogenase activity
HYN56_RS07800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HYN56_RS07810	COG0492	ferredoxin-NADP+ reductase activity
HYN56_RS07815	COG0646	methionine synthase
HYN56_RS07815	COG1410	methionine synthase
HYN56_RS07820	COG4804	nuclease activity
HYN56_RS07830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYN56_RS07840	COG1301	dicarboxylic acid transport
HYN56_RS07880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYN56_RS07890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYN56_RS07905	COG0590	tRNA wobble adenosine to inosine editing
HYN56_RS07930	COG4953	penicillin-binding protein 1C
HYN56_RS07950	COG0776	regulation of translation
HYN56_RS07955	COG1194	a g-specific adenine glycosylase
HYN56_RS07995	COG0612	Peptidase, M16
HYN56_RS08000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYN56_RS08005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYN56_RS08050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYN56_RS08055	COG0295	cytidine deaminase activity
HYN56_RS08070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYN56_RS08075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYN56_RS08085	COG1629	transport
HYN56_RS08100	COG1629	transport
HYN56_RS08145	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS08195	COG3177	Filamentation induced by cAMP protein fic
HYN56_RS08225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HYN56_RS08255	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HYN56_RS08315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYN56_RS08330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYN56_RS08340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HYN56_RS08350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYN56_RS08365	COG2022	thiamine diphosphate biosynthetic process
HYN56_RS08370	COG0352	thiamine-phosphate diphosphorylase activity
HYN56_RS08375	COG0351	phosphomethylpyrimidine kinase
HYN56_RS08385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HYN56_RS08395	COG0519	Catalyzes the synthesis of GMP from XMP
HYN56_RS08410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HYN56_RS08415	COG0339	signal peptide processing
HYN56_RS08420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYN56_RS08425	COG0052	Belongs to the universal ribosomal protein uS2 family
HYN56_RS08430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYN56_RS08435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYN56_RS08455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYN56_RS08455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYN56_RS08465	COG0745	RESPONSE REGULATOR receiver
HYN56_RS08470	COG3850	Histidine kinase
HYN56_RS08470	COG5002	protein histidine kinase activity
HYN56_RS08515	COG1012	belongs to the aldehyde dehydrogenase family
HYN56_RS08525	COG0779	Required for maturation of 30S ribosomal subunits
HYN56_RS08530	COG0195	Participates in both transcription termination and antitermination
HYN56_RS08530	COG2251	uridine kinase activity
HYN56_RS08535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYN56_RS08555	COG0437	4 iron, 4 sulfur cluster binding
HYN56_RS08580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HYN56_RS08585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYN56_RS08590	COG2255	four-way junction helicase activity
HYN56_RS08600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYN56_RS08620	COG0517	IMP dehydrogenase activity
HYN56_RS08630	COG0632	four-way junction helicase activity
HYN56_RS08640	COG0509	glycine decarboxylation via glycine cleavage system
HYN56_RS08650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYN56_RS08660	COG0109	protoheme IX farnesyltransferase activity
HYN56_RS08665	COG1845	cytochrome c oxidase, subunit III
HYN56_RS08670	COG1845	cytochrome c oxidase, subunit III
HYN56_RS08685	COG1999	signal sequence binding
HYN56_RS08690	COG2322	membrane
HYN56_RS08760	COG0577	efflux transmembrane transporter activity
HYN56_RS08760	COG1136	(ABC) transporter
HYN56_RS08765	COG0577	efflux transmembrane transporter activity
HYN56_RS08765	COG1136	(ABC) transporter
HYN56_RS08770	COG0577	efflux transmembrane transporter activity
HYN56_RS08770	COG1136	(ABC) transporter
HYN56_RS08790	COG1214	PFAM Peptidase M22, glycoprotease
HYN56_RS08815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HYN56_RS08825	COG3275	phosphorelay sensor kinase activity
HYN56_RS08855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYN56_RS08875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYN56_RS08885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYN56_RS08895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HYN56_RS08900	COG0596	Alpha beta hydrolase
HYN56_RS08905	COG1950	PFAM Membrane protein of
HYN56_RS08910	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYN56_RS08925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYN56_RS08935	COG4977	sequence-specific DNA binding
HYN56_RS08935	COG1917	Cupin 2, conserved barrel domain protein
HYN56_RS08965	COG3830	Belongs to the UPF0237 family
HYN56_RS08965	COG0560	Phosphoserine phosphatase
HYN56_RS09000	COG1073	alpha beta
HYN56_RS09005	COG0616	signal peptide processing
HYN56_RS09030	COG1428	Deoxynucleoside kinase
HYN56_RS09045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYN56_RS09055	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYN56_RS09100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYN56_RS09105	COG0697	spore germination
HYN56_RS09120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYN56_RS09135	COG2353	YceI-like domain
HYN56_RS09140	COG1741	Belongs to the pirin family
HYN56_RS09155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HYN56_RS09160	COG2224	Isocitrate lyase
HYN56_RS09175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HYN56_RS09180	COG0826	peptidase U32
HYN56_RS09185	COG3645	SOS response
HYN56_RS09200	COG3239	Fatty acid desaturase
HYN56_RS09205	COG0357	Ribosomal RNA small subunit methyltransferase G
HYN56_RS09215	COG1012	belongs to the aldehyde dehydrogenase family
HYN56_RS09220	COG2967	ApaG domain
HYN56_RS09230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYN56_RS09245	COG2733	membrane
HYN56_RS09250	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HYN56_RS09260	COG2989	Protein conserved in bacteria
HYN56_RS09280	COG3340	Belongs to the peptidase S51 family
HYN56_RS09310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYN56_RS09315	COG0671	phosphoesterase, PA-phosphatase related
HYN56_RS09325	COG4122	O-methyltransferase activity
HYN56_RS09355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYN56_RS09390	COG0358	DNA primase activity
HYN56_RS09400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYN56_RS09420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYN56_RS09430	COG2001	Belongs to the MraZ family
HYN56_RS09435	COG0275	rRNA processing
HYN56_RS09450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYN56_RS09455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYN56_RS09460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYN56_RS09470	COG0772	Belongs to the SEDS family
HYN56_RS09475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYN56_RS09480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYN56_RS09495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYN56_RS09500	COG1610	YqeY-like protein
HYN56_RS09510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYN56_RS09550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYN56_RS09555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS09560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYN56_RS09590	COG3279	Response regulator of the LytR AlgR family
HYN56_RS09610	COG0659	secondary active sulfate transmembrane transporter activity
HYN56_RS09620	COG0300	oxidoreductase activity
HYN56_RS09635	COG0459	protein refolding
HYN56_RS09640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYN56_RS09670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYN56_RS09685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYN56_RS09720	COG0488	(ABC) transporter
HYN56_RS09730	COG1597	lipid kinase activity
HYN56_RS09990	COG0739	heme binding
HYN56_RS10000	COG3590	peptidase
HYN56_RS10020	COG0519	Catalyzes the synthesis of GMP from XMP
HYN56_RS10120	COG1074	ATP-dependent DNA helicase activity
HYN56_RS10160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYN56_RS10165	COG1160	GTP binding
HYN56_RS10185	COG4771	TonB-dependent receptor
HYN56_RS10190	COG1959	2 iron, 2 sulfur cluster binding
HYN56_RS10195	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYN56_RS10205	COG1704	LemA family
HYN56_RS10215	COG0739	heme binding
HYN56_RS10220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYN56_RS10225	COG1132	(ABC) transporter
HYN56_RS10305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYN56_RS10315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYN56_RS10335	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYN56_RS10340	COG0791	NLP P60 protein
HYN56_RS10340	COG1388	LysM domain
HYN56_RS10345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYN56_RS10360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYN56_RS10370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYN56_RS10385	COG0321	lipoyl(octanoyl) transferase activity
HYN56_RS10395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYN56_RS10410	COG2176	DNA-directed DNA polymerase activity
HYN56_RS10425	COG0531	amino acid
HYN56_RS10435	COG1960	acyl-CoA dehydrogenase activity
HYN56_RS10440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYN56_RS10445	COG4974	Belongs to the 'phage' integrase family
HYN56_RS10470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYN56_RS10490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYN56_RS10495	COG0081	regulation of translation
HYN56_RS10500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYN56_RS10505	COG0222	ribosome binding
HYN56_RS10510	COG0085	RNA polymerase activity
HYN56_RS10515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYN56_RS10530	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYN56_RS10540	COG0714	Associated with various cellular activities
HYN56_RS10565	COG0791	NLP P60 protein
HYN56_RS10570	COG0643	Histidine kinase
HYN56_RS10570	COG0784	Response regulator, receiver
HYN56_RS10570	COG2198	Histidine kinase
HYN56_RS10575	COG2198	Histidine kinase
HYN56_RS10575	COG5002	protein histidine kinase activity
HYN56_RS10575	COG0784	Response regulator, receiver
HYN56_RS10580	COG4106	trans-aconitate 2-methyltransferase activity
HYN56_RS10590	COG0531	amino acid
HYN56_RS10615	COG1199	ATP-dependent helicase activity
HYN56_RS10615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYN56_RS10620	COG0587	DNA-directed DNA polymerase activity
HYN56_RS10625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYN56_RS10630	COG1396	sequence-specific DNA binding
HYN56_RS10635	COG0671	phosphoesterase, PA-phosphatase related
HYN56_RS10640	COG5002	protein histidine kinase activity
HYN56_RS10645	COG2205	protein histidine kinase activity
HYN56_RS10655	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HYN56_RS10660	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HYN56_RS10665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HYN56_RS10680	COG2204	response regulator
HYN56_RS10690	COG3604	Transcriptional regulator
HYN56_RS10710	COG1131	(ABC) transporter
HYN56_RS10715	COG3655	Transcriptional regulator
HYN56_RS10725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYN56_RS10760	COG2267	carboxylic ester hydrolase activity
HYN56_RS10770	COG1609	Transcriptional regulator
HYN56_RS10780	COG1881	PFAM PEBP family protein
HYN56_RS10785	COG3661	Belongs to the glycosyl hydrolase 67 family
HYN56_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS10795	COG1312	Catalyzes the dehydration of D-mannonate
HYN56_RS10810	COG2211	Major facilitator Superfamily
HYN56_RS10835	COG2115	Belongs to the xylose isomerase family
HYN56_RS10840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYN56_RS10845	COG4771	TonB-dependent receptor
HYN56_RS10850	COG0561	phosphatase activity
HYN56_RS10875	COG0583	DNA-binding transcription factor activity
HYN56_RS10905	COG1629	transport
HYN56_RS10905	COG4206	TonB-dependent receptor
HYN56_RS10915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS10920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS10940	COG0456	acetyltransferase
HYN56_RS10940	COG1846	Transcriptional regulator
HYN56_RS10945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYN56_RS10945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYN56_RS10950	COG4771	TonB-dependent receptor
HYN56_RS10955	COG0702	epimerase
HYN56_RS10960	COG0363	glucosamine-6-phosphate deaminase activity
HYN56_RS10975	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYN56_RS10980	COG1129	ABC transporter
HYN56_RS10995	COG3958	Transketolase
HYN56_RS11000	COG3959	Transketolase, thiamine diphosphate binding domain
HYN56_RS11010	COG1349	DNA-binding transcription factor activity
HYN56_RS11150	COG1064	alcohol dehydrogenase
HYN56_RS11155	COG1024	Enoyl-CoA hydratase
HYN56_RS11175	COG2267	carboxylic ester hydrolase activity
HYN56_RS11185	COG0300	oxidoreductase activity
HYN56_RS11190	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS11205	COG0300	oxidoreductase activity
HYN56_RS11210	COG4977	sequence-specific DNA binding
HYN56_RS11210	COG1917	Cupin 2, conserved barrel domain protein
HYN56_RS11225	COG0604	alcohol dehydrogenase
HYN56_RS11235	COG2801	Transposase and inactivated derivatives
HYN56_RS11395	COG0587	DNA-directed DNA polymerase activity
HYN56_RS11400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYN56_RS11410	COG2003	Belongs to the UPF0758 family
HYN56_RS11425	COG0629	single-stranded DNA binding
HYN56_RS11430	COG1570	exodeoxyribonuclease VII activity
HYN56_RS11440	COG0210	DNA helicase
HYN56_RS11500	COG4771	TonB-dependent receptor
HYN56_RS11635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYN56_RS11635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYN56_RS11650	COG1674	ftsk spoiiie
HYN56_RS11660	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYN56_RS11675	COG0450	alkyl hydroperoxide reductase
HYN56_RS11680	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS11695	COG2211	Major facilitator Superfamily
HYN56_RS11700	COG1649	PFAM Uncharacterised BCR, COG1649
HYN56_RS11710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HYN56_RS11715	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS11720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYN56_RS11725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HYN56_RS11730	COG3876	Protein conserved in bacteria
HYN56_RS11735	COG0702	epimerase
HYN56_RS11740	COG4771	TonB-dependent receptor
HYN56_RS11745	COG1349	DNA-binding transcription factor activity
HYN56_RS11750	COG3693	PFAM glycoside hydrolase, family 10
HYN56_RS11750	COG2382	esterase
HYN56_RS11760	COG1649	PFAM Uncharacterised BCR, COG1649
HYN56_RS11765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYN56_RS11770	COG0247	lactate metabolic process
HYN56_RS11770	COG0277	FAD linked oxidase domain protein
HYN56_RS11775	COG0673	inositol 2-dehydrogenase activity
HYN56_RS11780	COG0531	amino acid
HYN56_RS11780	COG0531	amino acid
HYN56_RS11800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYN56_RS11820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYN56_RS11825	COG0037	tRNA processing
HYN56_RS11835	COG0004	ammonium transporteR
HYN56_RS11845	COG0606	chelatase, subunit chli
HYN56_RS11950	COG0019	diaminopimelate decarboxylase activity
HYN56_RS11965	COG0070	glutamate synthase
HYN56_RS11965	COG0069	glutamate synthase activity
HYN56_RS11965	COG0067	glutamate synthase
HYN56_RS11970	COG0045	succinate-CoA ligase (ADP-forming) activity
HYN56_RS11990	COG3279	Response regulator of the LytR AlgR family
HYN56_RS12005	COG4948	Mandelate Racemase Muconate Lactonizing
HYN56_RS12020	COG0556	nucleotide-excision repair
HYN56_RS12025	COG0596	Alpha beta hydrolase
HYN56_RS12035	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HYN56_RS12080	COG0335	large ribosomal subunit rRNA binding
HYN56_RS12085	COG0336	Belongs to the RNA methyltransferase TrmD family
HYN56_RS12115	COG2814	Major facilitator Superfamily
HYN56_RS12120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYN56_RS12130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYN56_RS12145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYN56_RS12165	COG1132	(ABC) transporter
HYN56_RS12175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYN56_RS12180	COG1862	Preprotein translocase
HYN56_RS12190	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYN56_RS12195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYN56_RS12220	COG0167	dihydroorotate dehydrogenase activity
HYN56_RS12250	COG0517	IMP dehydrogenase activity
HYN56_RS12250	COG0516	GMP reductase activity
HYN56_RS12255	COG0202	RNA polymerase activity
HYN56_RS12285	COG0494	nUDIX hydrolase
HYN56_RS12290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYN56_RS12300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYN56_RS12305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYN56_RS12325	COG0714	Associated with various cellular activities
HYN56_RS12360	COG2860	membrane
HYN56_RS12385	COG0438	transferase activity, transferring glycosyl groups
HYN56_RS12395	COG0463	Glycosyl transferase, family 2
HYN56_RS12395	COG1216	Glycosyl transferase, family 2
HYN56_RS12405	COG2884	Cell division ATP-binding protein ftsE
HYN56_RS12415	COG0384	phenazine biosynthesis protein PhzF
HYN56_RS12425	COG3153	acetyltransferase
HYN56_RS12435	COG0367	asparagine synthase
HYN56_RS12440	COG0367	asparagine synthase
HYN56_RS12445	COG0187	DNA topoisomerase II activity
HYN56_RS12450	COG0039	L-malate dehydrogenase activity
HYN56_RS12455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYN56_RS12465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYN56_RS12470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYN56_RS12475	COG0215	cysteine-tRNA ligase activity
HYN56_RS12480	COG0302	gtp cyclohydrolase
HYN56_RS12520	COG0525	valine-tRNA ligase activity
HYN56_RS12565	COG2223	nitrite transmembrane transporter activity
HYN56_RS12660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYN56_RS12710	COG4251	negative regulation of phosphorylation
HYN56_RS12715	COG0784	Response regulator, receiver
HYN56_RS12725	COG3237	CsbD-like
HYN56_RS12730	COG0783	Belongs to the Dps family
HYN56_RS12735	COG0284	orotidine-5'-phosphate decarboxylase activity
HYN56_RS12740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYN56_RS12745	COG0753	catalase activity
HYN56_RS12750	COG0788	formyltetrahydrofolate deformylase activity
HYN56_RS12770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN56_RS12770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN56_RS12770	COG1703	isobutyryl-CoA mutase activity
HYN56_RS12835	COG0174	glutamine synthetase
HYN56_RS12850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYN56_RS12865	COG3537	Alpha-1,2-mannosidase
HYN56_RS12905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYN56_RS12910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYN56_RS12920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYN56_RS12925	COG0038	chloride channel
HYN56_RS12940	COG0484	heat shock protein binding
HYN56_RS12955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYN56_RS12955	COG0519	Catalyzes the synthesis of GMP from XMP
HYN56_RS12975	COG0673	inositol 2-dehydrogenase activity
HYN56_RS12990	COG4771	TonB-dependent receptor
HYN56_RS13010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYN56_RS13020	COG0363	glucosamine-6-phosphate deaminase activity
HYN56_RS13025	COG3530	Putative quorum-sensing-regulated virulence factor
HYN56_RS13030	COG0504	CTP synthase activity
HYN56_RS13035	COG0706	membrane insertase activity
HYN56_RS13055	COG0482	sulfurtransferase activity
HYN56_RS13110	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYN56_RS13125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYN56_RS13135	COG2205	protein histidine kinase activity
HYN56_RS13140	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYN56_RS13155	COG0069	glutamate synthase activity
HYN56_RS13165	COG1959	2 iron, 2 sulfur cluster binding
HYN56_RS13170	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HYN56_RS13190	COG1999	signal sequence binding
HYN56_RS13195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYN56_RS13195	COG0515	serine threonine protein kinase
HYN56_RS13205	COG0156	8-amino-7-oxononanoate synthase activity
HYN56_RS13260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYN56_RS13265	COG1595	DNA-templated transcription, initiation
HYN56_RS13275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYN56_RS13280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYN56_RS13290	COG1234	tRNA 3'-trailer cleavage
HYN56_RS13325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYN56_RS13335	COG2706	6-phosphogluconolactonase activity
HYN56_RS13340	COG0513	Belongs to the DEAD box helicase family
HYN56_RS13390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYN56_RS13395	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HYN56_RS13405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYN56_RS13415	COG4771	TonB-dependent receptor
HYN56_RS13430	COG1295	ribonuclease BN
HYN56_RS13435	COG0431	NADPH-dependent FMN reductase
HYN56_RS13445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYN56_RS13470	COG0542	response to heat
HYN56_RS13480	COG0791	NLP P60 protein
HYN56_RS13505	COG3179	chitinase
HYN56_RS13585	COG1858	cytochrome C peroxidase
HYN56_RS13595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYN56_RS13620	COG1733	regulation of RNA biosynthetic process
HYN56_RS13645	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HYN56_RS13665	COG2226	methyltransferase
HYN56_RS13670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HYN56_RS13670	COG0116	Belongs to the methyltransferase superfamily
HYN56_RS13680	COG1794	racemase activity, acting on amino acids and derivatives
HYN56_RS13695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYN56_RS13700	COG2205	protein histidine kinase activity
HYN56_RS13710	COG0667	Aldo Keto reductase
HYN56_RS13720	COG1045	serine acetyltransferase
HYN56_RS13750	COG1104	cysteine desulfurase activity
HYN56_RS13755	COG0009	L-threonylcarbamoyladenylate synthase
HYN56_RS13765	COG0438	transferase activity, transferring glycosyl groups
HYN56_RS13775	COG0463	Glycosyl transferase, family 2
HYN56_RS13785	COG2171	N-acyltransferase activity
HYN56_RS13790	COG0840	transmembrane signaling receptor activity
HYN56_RS13800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYN56_RS13805	COG0579	oxidoreductase
HYN56_RS13810	COG1289	transmembrane transporter activity
HYN56_RS13815	COG0242	peptide deformylase activity
HYN56_RS13825	COG3956	TIGRFAM MazG family protein
HYN56_RS13830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYN56_RS13845	COG3278	Belongs to the heme-copper respiratory oxidase family
HYN56_RS13860	COG0348	domain, Protein
HYN56_RS13875	COG2361	Protein of unknown function DUF86
HYN56_RS13885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYN56_RS13905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYN56_RS13920	COG2814	Major facilitator Superfamily
HYN56_RS13935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN56_RS13950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYN56_RS14015	COG0217	transcriptional regulatory protein
HYN56_RS14020	COG0793	Belongs to the peptidase S41A family
HYN56_RS14025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYN56_RS14030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYN56_RS14090	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYN56_RS14095	COG0083	homoserine kinase activity
HYN56_RS14105	COG2986	histidine ammonia-lyase
HYN56_RS14115	COG0306	phosphate transporter
HYN56_RS14120	COG2323	membrane
HYN56_RS14125	COG0189	ligase activity
HYN56_RS14125	COG4067	protein conserved in archaea
HYN56_RS14130	COG0542	response to heat
HYN56_RS14145	COG1764	response to oxidative stress
HYN56_RS14160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYN56_RS14170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYN56_RS14180	COG1523	belongs to the glycosyl hydrolase 13 family
HYN56_RS14185	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYN56_RS14190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYN56_RS14200	COG0688	phosphatidylethanolamine metabolic process
HYN56_RS14205	COG4589	Belongs to the CDS family
HYN56_RS14215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYN56_RS14220	COG0799	negative regulation of ribosome biogenesis
HYN56_RS14235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYN56_RS14240	COG1051	belongs to the nudix hydrolase family
HYN56_RS14270	COG0513	Belongs to the DEAD box helicase family
HYN56_RS14280	COG2824	Alkylphosphonate utilization operon protein PhnA
HYN56_RS14285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYN56_RS14290	COG2323	membrane
HYN56_RS14295	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYN56_RS14305	COG0564	pseudouridine synthase activity
HYN56_RS14315	COG1119	ATPase activity
HYN56_RS14335	COG2267	carboxylic ester hydrolase activity
HYN56_RS14345	COG0668	transmembrane transport
HYN56_RS14370	COG0025	NhaP-type Na H and K H
HYN56_RS14380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS14385	COG0443	Heat shock 70 kDa protein
HYN56_RS14390	COG0598	Magnesium transport protein CorA
HYN56_RS14395	COG0280	phosphate acetyltransferase
HYN56_RS14395	COG0857	belongs to the CobB CobQ family
HYN56_RS14400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYN56_RS14415	COG4771	TonB-dependent receptor
HYN56_RS14420	COG0702	epimerase
HYN56_RS14435	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS14465	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HYN56_RS14475	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HYN56_RS14510	COG2264	protein methyltransferase activity
HYN56_RS14515	COG0149	triose-phosphate isomerase activity
HYN56_RS14520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS14545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYN56_RS14560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HYN56_RS14565	COG2329	Antibiotic biosynthesis monooxygenase
HYN56_RS14585	COG1741	Belongs to the pirin family
HYN56_RS14595	COG4335	DNA alkylation repair
HYN56_RS14630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYN56_RS14635	COG3279	Response regulator of the LytR AlgR family
HYN56_RS14640	COG0360	Binds together with S18 to 16S ribosomal RNA
HYN56_RS14645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYN56_RS14650	COG0359	binds to the 23S rRNA
HYN56_RS14675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HYN56_RS14675	COG2885	chlorophyll binding
HYN56_RS14680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYN56_RS14690	COG0737	Belongs to the 5'-nucleotidase family
HYN56_RS14695	COG0737	Belongs to the 5'-nucleotidase family
HYN56_RS14705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYN56_RS14730	COG0497	DNA recombination
HYN56_RS14740	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYN56_RS14750	COG0237	dephospho-CoA kinase activity
HYN56_RS14765	COG1690	Belongs to the RtcB family
HYN56_RS14770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HYN56_RS14785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYN56_RS14790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYN56_RS14805	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYN56_RS14810	COG0673	inositol 2-dehydrogenase activity
HYN56_RS14815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYN56_RS14830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYN56_RS14840	COG4628	conserved protein (DUF2132)
HYN56_RS14850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYN56_RS14870	COG0137	argininosuccinate synthase activity
HYN56_RS14875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HYN56_RS14880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYN56_RS14890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HYN56_RS14900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYN56_RS14905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HYN56_RS14915	COG0165	Argininosuccinate lyase
HYN56_RS14940	COG0542	response to heat
HYN56_RS14955	COG2354	Protein conserved in bacteria
HYN56_RS14985	COG2957	Belongs to the agmatine deiminase family
HYN56_RS15000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYN56_RS15010	COG0516	GMP reductase activity
HYN56_RS15040	COG5002	protein histidine kinase activity
HYN56_RS15050	COG3781	membrane
HYN56_RS15055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYN56_RS15075	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS15095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYN56_RS15105	COG1902	pentaerythritol trinitrate reductase activity
HYN56_RS15110	COG0640	Transcriptional regulator
HYN56_RS15115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYN56_RS15130	COG3250	beta-galactosidase activity
HYN56_RS15145	COG1064	alcohol dehydrogenase
HYN56_RS15150	COG0667	Aldo Keto reductase
HYN56_RS15195	COG3685	Protein conserved in bacteria
HYN56_RS15200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYN56_RS15215	COG0784	Response regulator, receiver
HYN56_RS15220	COG4251	negative regulation of phosphorylation
HYN56_RS15235	COG4095	Psort location CytoplasmicMembrane, score
HYN56_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS15245	COG4251	negative regulation of phosphorylation
HYN56_RS15250	COG0784	Response regulator, receiver
HYN56_RS15250	COG2205	protein histidine kinase activity
HYN56_RS15255	COG2205	protein histidine kinase activity
HYN56_RS15255	COG3437	response regulator, receiver
HYN56_RS15255	COG3850	Histidine kinase
HYN56_RS15255	COG4999	Histidine kinase
HYN56_RS15260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYN56_RS15315	COG2217	Heavy metal translocating P-type atpase
HYN56_RS15320	COG1942	4-Oxalocrotonate Tautomerase
HYN56_RS15330	COG1858	cytochrome C peroxidase
HYN56_RS15345	COG1629	transport
HYN56_RS15375	COG1131	(ABC) transporter
HYN56_RS15390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYN56_RS15395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYN56_RS15400	COG1053	succinate dehydrogenase
HYN56_RS15405	COG0183	Belongs to the thiolase family
HYN56_RS15425	COG0730	response to heat
HYN56_RS15435	COG0657	acetylesterase activity
HYN56_RS15440	COG1764	response to oxidative stress
HYN56_RS15450	COG1247	-acetyltransferase
HYN56_RS15470	COG2972	Histidine kinase
HYN56_RS15475	COG0745	RESPONSE REGULATOR receiver
HYN56_RS15480	COG3292	Two component regulator propeller
HYN56_RS15480	COG3292	Two component regulator propeller
HYN56_RS15480	COG0745	RESPONSE REGULATOR receiver
HYN56_RS15480	COG0745	RESPONSE REGULATOR receiver
HYN56_RS15480	COG2205	protein histidine kinase activity
HYN56_RS15480	COG2205	protein histidine kinase activity
HYN56_RS15485	COG4771	TonB-dependent receptor
HYN56_RS15510	COG3250	beta-galactosidase activity
HYN56_RS15530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYN56_RS15540	COG2885	chlorophyll binding
HYN56_RS15640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYN56_RS15650	COG0640	Transcriptional regulator
HYN56_RS15700	COG0702	epimerase
HYN56_RS15740	COG0577	efflux transmembrane transporter activity
HYN56_RS15740	COG1136	(ABC) transporter
HYN56_RS15755	COG0129	dihydroxy-acid dehydratase activity
HYN56_RS15770	COG4251	negative regulation of phosphorylation
HYN56_RS15790	COG2153	protein acetylation
HYN56_RS15795	COG2076	Multidrug Resistance protein
HYN56_RS15900	COG0363	glucosamine-6-phosphate deaminase activity
HYN56_RS15905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HYN56_RS15910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HYN56_RS15915	COG0387	Pfam Sodium calcium exchanger
HYN56_RS15920	COG1733	regulation of RNA biosynthetic process
HYN56_RS15930	COG4251	negative regulation of phosphorylation
HYN56_RS15935	COG4251	negative regulation of phosphorylation
HYN56_RS15940	COG4251	negative regulation of phosphorylation
HYN56_RS15945	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HYN56_RS15950	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS15955	COG0583	DNA-binding transcription factor activity
HYN56_RS15965	COG1764	response to oxidative stress
HYN56_RS16030	COG1764	response to oxidative stress
HYN56_RS16040	COG3275	phosphorelay sensor kinase activity
HYN56_RS16065	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS16070	COG1942	4-Oxalocrotonate Tautomerase
HYN56_RS16090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYN56_RS16100	COG3279	Response regulator of the LytR AlgR family
HYN56_RS16150	COG0612	Peptidase, M16
HYN56_RS16170	COG4206	TonB-dependent receptor
HYN56_RS16170	COG1629	transport
HYN56_RS16190	COG1335	isochorismatase
HYN56_RS16235	COG3119	arylsulfatase activity
HYN56_RS16285	COG0693	protein deglycase activity
HYN56_RS16290	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HYN56_RS16320	COG4771	TonB-dependent receptor
HYN56_RS16340	COG4771	TonB-dependent receptor
HYN56_RS16350	COG2205	protein histidine kinase activity
HYN56_RS16395	COG4771	TonB-dependent receptor
HYN56_RS16410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS16415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS16445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYN56_RS16450	COG2094	Belongs to the DNA glycosylase MPG family
HYN56_RS16455	COG0477	Major facilitator Superfamily
HYN56_RS16470	COG3620	sequence-specific DNA binding
HYN56_RS16535	COG4221	oxidoreductase activity
HYN56_RS16555	COG1538	Outer membrane efflux protein
HYN56_RS16565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS16575	COG0656	L-ascorbic acid biosynthetic process
HYN56_RS16580	COG1113	amino acid transport
HYN56_RS16615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYN56_RS16635	COG0784	Response regulator, receiver
HYN56_RS16635	COG2205	protein histidine kinase activity
HYN56_RS16670	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYN56_RS16680	COG0346	lactoylglutathione lyase activity
HYN56_RS16685	COG3604	Transcriptional regulator
HYN56_RS16690	COG3548	integral membrane protein
HYN56_RS16695	COG2204	response regulator
HYN56_RS16710	COG0783	Belongs to the Dps family
HYN56_RS16735	COG1335	isochorismatase
HYN56_RS16750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYN56_RS16755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HYN56_RS16755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYN56_RS16760	COG0450	alkyl hydroperoxide reductase
HYN56_RS16770	COG2140	Oxalate decarboxylase
HYN56_RS16780	COG0604	alcohol dehydrogenase
HYN56_RS16780	COG3321	synthase
HYN56_RS16805	COG0783	Belongs to the Dps family
HYN56_RS16810	COG0778	Nitroreductase
HYN56_RS16820	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYN56_RS16835	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYN56_RS16870	COG4771	TonB-dependent receptor
HYN56_RS16890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS16895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS16900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYN56_RS16910	COG0300	oxidoreductase activity
HYN56_RS16940	COG0071	Belongs to the small heat shock protein (HSP20) family
HYN56_RS16960	COG0745	RESPONSE REGULATOR receiver
HYN56_RS16960	COG2205	protein histidine kinase activity
HYN56_RS16960	COG3292	Two component regulator propeller
HYN56_RS16965	COG2814	Major facilitator Superfamily
HYN56_RS16970	COG1621	beta-fructofuranosidase activity
HYN56_RS16975	COG4206	TonB-dependent receptor
HYN56_RS16975	COG1629	transport
HYN56_RS16980	COG0702	epimerase
HYN56_RS17035	COG1595	DNA-templated transcription, initiation
HYN56_RS17070	COG0110	maltose O-acetyltransferase activity
HYN56_RS17085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYN56_RS17095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HYN56_RS17100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYN56_RS17145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYN56_RS17155	COG1595	DNA-templated transcription, initiation
HYN56_RS17175	COG4251	negative regulation of phosphorylation
HYN56_RS17185	COG4251	negative regulation of phosphorylation
HYN56_RS17240	COG4251	negative regulation of phosphorylation
HYN56_RS17250	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS17255	COG0702	epimerase
HYN56_RS17260	COG2201	protein-glutamate methylesterase activity
HYN56_RS17275	COG3119	arylsulfatase activity
HYN56_RS17290	COG2801	Transposase and inactivated derivatives
HYN56_RS17325	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HYN56_RS17330	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HYN56_RS17340	COG2201	protein-glutamate methylesterase activity
HYN56_RS17350	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYN56_RS17375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYN56_RS17385	COG4585	Histidine kinase
HYN56_RS17420	COG1012	belongs to the aldehyde dehydrogenase family
HYN56_RS17435	COG4977	sequence-specific DNA binding
HYN56_RS17435	COG1917	Cupin 2, conserved barrel domain protein
HYN56_RS17440	COG3781	membrane
HYN56_RS17450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN56_RS17455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS17475	COG0840	transmembrane signaling receptor activity
HYN56_RS17480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYN56_RS17515	COG0308	aminopeptidase N
HYN56_RS17535	COG0730	response to heat
HYN56_RS17550	COG0009	L-threonylcarbamoyladenylate synthase
HYN56_RS17580	COG0488	(ABC) transporter
HYN56_RS17585	COG3011	Protein conserved in bacteria
HYN56_RS17590	COG1193	negative regulation of DNA recombination
HYN56_RS17595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYN56_RS17605	COG0686	Belongs to the AlaDH PNT family
HYN56_RS17610	COG0802	atpase or kinase
HYN56_RS17615	COG2204	response regulator
HYN56_RS17620	COG1078	dGTPase activity
HYN56_RS17625	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN56_RS17630	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HYN56_RS17630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYN56_RS17635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN56_RS17640	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYN56_RS17645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN56_RS17655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYN56_RS17680	COG4771	TonB-dependent receptor
HYN56_RS17700	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS17725	COG0583	DNA-binding transcription factor activity
HYN56_RS17730	COG2855	membrane
HYN56_RS17745	COG1368	sulfuric ester hydrolase activity
HYN56_RS17750	COG0745	RESPONSE REGULATOR receiver
HYN56_RS17755	COG5002	protein histidine kinase activity
HYN56_RS17760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HYN56_RS17765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYN56_RS17770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYN56_RS17775	COG0131	Imidazoleglycerol-phosphate dehydratase
HYN56_RS17785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HYN56_RS17790	COG0107	imidazoleglycerol-phosphate synthase activity
HYN56_RS17795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HYN56_RS17795	COG0140	phosphoribosyl-ATP diphosphatase activity
HYN56_RS17825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYN56_RS17835	COG0129	dihydroxy-acid dehydratase activity
HYN56_RS17840	COG0028	Belongs to the TPP enzyme family
HYN56_RS17845	COG0440	acetolactate synthase activity
HYN56_RS17850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYN56_RS17855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYN56_RS17870	COG1595	DNA-templated transcription, initiation
HYN56_RS17875	COG0386	Belongs to the glutathione peroxidase family
HYN56_RS17880	COG1247	-acetyltransferase
HYN56_RS17890	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HYN56_RS17895	COG2996	Protein conserved in bacteria
HYN56_RS17905	COG1575	Belongs to the MenA family. Type 1 subfamily
HYN56_RS17910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYN56_RS17930	COG2885	chlorophyll binding
HYN56_RS17935	COG2954	triphosphatase activity
HYN56_RS17940	COG0492	ferredoxin-NADP+ reductase activity
HYN56_RS17945	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HYN56_RS18000	COG1522	sequence-specific DNA binding
HYN56_RS18005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HYN56_RS18015	COG0514	ATP-dependent DNA helicase (RecQ)
HYN56_RS18040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYN56_RS18050	COG1132	(ABC) transporter
HYN56_RS18080	COG0681	Belongs to the peptidase S26 family
HYN56_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS18130	COG0024	Methionine aminopeptidase
HYN56_RS18135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYN56_RS18140	COG1045	serine acetyltransferase
HYN56_RS18175	COG0640	Transcriptional regulator
HYN56_RS18190	COG0488	(ABC) transporter
HYN56_RS18220	COG0813	purine-nucleoside phosphorylase activity
HYN56_RS18240	COG1064	alcohol dehydrogenase
HYN56_RS18265	COG0668	transmembrane transport
HYN56_RS18285	COG0513	Belongs to the DEAD box helicase family
HYN56_RS18290	COG1252	NADH dehydrogenase
HYN56_RS18300	COG2801	Transposase and inactivated derivatives
HYN56_RS18305	COG2814	Major facilitator Superfamily
HYN56_RS18335	COG2176	DNA-directed DNA polymerase activity
HYN56_RS18340	COG1333	cytochrome c biogenesis protein
HYN56_RS18340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYN56_RS18350	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HYN56_RS18360	COG0424	maF-like protein
HYN56_RS18370	COG0628	permease
HYN56_RS18425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYN56_RS18430	COG0084	hydrolase, TatD family'
HYN56_RS18480	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HYN56_RS18510	COG2211	Major facilitator Superfamily
HYN56_RS18515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYN56_RS18525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYN56_RS18535	COG1595	DNA-templated transcription, initiation
HYN56_RS18555	COG2270	Major facilitator Superfamily
HYN56_RS18570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYN56_RS18575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYN56_RS18580	COG0297	glycogen (starch) synthase activity
HYN56_RS18590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYN56_RS18650	COG1363	Peptidase, m42
HYN56_RS18655	COG0745	RESPONSE REGULATOR receiver
HYN56_RS18660	COG2205	protein histidine kinase activity
HYN56_RS18700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYN56_RS18705	COG0561	phosphatase activity
HYN56_RS18720	COG1702	phosphate starvation-inducible protein PhoH
HYN56_RS18725	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HYN56_RS18745	COG0592	DNA-directed DNA polymerase activity
HYN56_RS18750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYN56_RS18770	COG1793	dna ligase
HYN56_RS18775	COG1201	RNA secondary structure unwinding
HYN56_RS18785	COG4716	Myosin-crossreactive antigen
HYN56_RS18825	COG2972	Histidine kinase
HYN56_RS18825	COG0745	RESPONSE REGULATOR receiver
HYN56_RS18830	COG3279	Response regulator of the LytR AlgR family
HYN56_RS18845	COG3264	Mechanosensitive ion channel
HYN56_RS18845	COG1196	nuclear chromosome segregation
HYN56_RS18850	COG3920	Histidine kinase
HYN56_RS18870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYN56_RS18925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HYN56_RS18930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYN56_RS18935	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HYN56_RS18970	COG4771	TonB-dependent receptor
HYN56_RS18975	COG0745	RESPONSE REGULATOR receiver
HYN56_RS18975	COG2205	protein histidine kinase activity
HYN56_RS18975	COG3292	Two component regulator propeller
HYN56_RS18980	COG3292	Two component regulator propeller
HYN56_RS18980	COG0745	RESPONSE REGULATOR receiver
HYN56_RS18980	COG2205	protein histidine kinase activity
HYN56_RS18995	COG3279	Response regulator of the LytR AlgR family
HYN56_RS19000	COG2972	Histidine kinase
HYN56_RS19010	COG1309	transcriptional regulator
HYN56_RS19015	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS19020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYN56_RS19025	COG1335	isochorismatase
HYN56_RS19030	COG4948	Mandelate Racemase Muconate Lactonizing
HYN56_RS19035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYN56_RS19040	COG0438	transferase activity, transferring glycosyl groups
HYN56_RS19085	COG4677	pectinesterase activity
HYN56_RS19095	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYN56_RS19105	COG0702	epimerase
HYN56_RS19110	COG4771	TonB-dependent receptor
HYN56_RS19120	COG3292	Two component regulator propeller
HYN56_RS19120	COG2205	protein histidine kinase activity
HYN56_RS19120	COG0745	RESPONSE REGULATOR receiver
HYN56_RS19125	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS19130	COG0668	transmembrane transport
HYN56_RS19150	COG0346	lactoylglutathione lyase activity
HYN56_RS19165	COG4771	TonB-dependent receptor
HYN56_RS19175	COG3604	Transcriptional regulator
HYN56_RS19190	COG0402	S-adenosylhomocysteine deaminase activity
HYN56_RS19210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HYN56_RS19225	COG0745	RESPONSE REGULATOR receiver
HYN56_RS19225	COG2205	protein histidine kinase activity
HYN56_RS19225	COG3292	Two component regulator propeller
HYN56_RS19260	COG1629	transport
HYN56_RS19290	COG3940	Belongs to the glycosyl hydrolase 43 family
HYN56_RS19295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYN56_RS19330	COG1629	transport
HYN56_RS19330	COG4206	TonB-dependent receptor
HYN56_RS19345	COG3250	beta-galactosidase activity
HYN56_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS19365	COG2814	Major facilitator Superfamily
HYN56_RS19370	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYN56_RS19380	COG1082	Xylose isomerase domain protein TIM barrel
HYN56_RS19400	COG4677	pectinesterase activity
HYN56_RS19425	COG0561	phosphatase activity
HYN56_RS19430	COG4771	TonB-dependent receptor
HYN56_RS19435	COG2205	protein histidine kinase activity
HYN56_RS19435	COG3292	Two component regulator propeller
HYN56_RS19435	COG0745	RESPONSE REGULATOR receiver
HYN56_RS19480	COG4771	TonB-dependent receptor
HYN56_RS19495	COG0531	amino acid
HYN56_RS19500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYN56_RS19515	COG3938	Belongs to the proline racemase family
HYN56_RS19520	COG1012	belongs to the aldehyde dehydrogenase family
HYN56_RS19540	COG1506	peptidase
HYN56_RS19540	COG0823	Involved in the tonB-independent uptake of proteins
HYN56_RS19545	COG0006	proline dipeptidase activity
HYN56_RS19555	COG4948	Mandelate Racemase Muconate Lactonizing
HYN56_RS19580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS19585	COG1649	PFAM Uncharacterised BCR, COG1649
HYN56_RS19595	COG3250	beta-galactosidase activity
HYN56_RS19610	COG3401	FG-GAP repeat protein
HYN56_RS19625	COG2755	lipolytic protein G-D-S-L family
HYN56_RS19635	COG2755	lipolytic protein G-D-S-L family
HYN56_RS19665	COG3254	rhamnose metabolic process
HYN56_RS19685	COG4771	TonB-dependent receptor
HYN56_RS19695	COG4771	TonB-dependent receptor
HYN56_RS19700	COG0702	epimerase
HYN56_RS19705	COG1629	transport
HYN56_RS19720	COG3250	beta-galactosidase activity
HYN56_RS19725	COG2755	lipolytic protein G-D-S-L family
HYN56_RS19725	COG0657	acetylesterase activity
HYN56_RS19815	COG1404	Belongs to the peptidase S8 family
HYN56_RS19820	COG1404	Belongs to the peptidase S8 family
HYN56_RS19955	COG2801	Transposase and inactivated derivatives
HYN56_RS19960	COG2003	Belongs to the UPF0758 family
HYN56_RS19975	COG4974	Belongs to the 'phage' integrase family
HYN56_RS19990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYN56_RS20000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYN56_RS20015	COG0025	NhaP-type Na H and K H
HYN56_RS20025	COG2801	Transposase and inactivated derivatives
HYN56_RS20030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYN56_RS20080	COG1733	regulation of RNA biosynthetic process
HYN56_RS20105	COG4771	TonB-dependent receptor
HYN56_RS20110	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS20130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYN56_RS20135	COG1446	asparaginase
HYN56_RS20150	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYN56_RS20160	COG3537	Alpha-1,2-mannosidase
HYN56_RS20170	COG3279	Response regulator of the LytR AlgR family
HYN56_RS20175	COG0363	glucosamine-6-phosphate deaminase activity
HYN56_RS20190	COG0612	Peptidase, M16
HYN56_RS20205	COG3118	belongs to the thioredoxin family
HYN56_RS20215	COG4206	TonB-dependent receptor
HYN56_RS20215	COG1629	transport
HYN56_RS20240	COG0385	Bile acid
HYN56_RS20260	COG3250	beta-galactosidase activity
HYN56_RS20285	COG3408	Glycogen debranching enzyme
HYN56_RS20310	COG3408	Glycogen debranching enzyme
HYN56_RS20360	COG0702	epimerase
HYN56_RS20365	COG1629	transport
HYN56_RS20365	COG4206	TonB-dependent receptor
HYN56_RS20395	COG3940	Belongs to the glycosyl hydrolase 43 family
HYN56_RS20400	COG3250	beta-galactosidase activity
HYN56_RS20415	COG3408	Glycogen debranching enzyme
HYN56_RS20415	COG3119	arylsulfatase activity
HYN56_RS20425	COG2223	nitrite transmembrane transporter activity
HYN56_RS20465	COG1063	alcohol dehydrogenase
HYN56_RS20470	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYN56_RS20485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYN56_RS20505	COG0738	Major facilitator superfamily
HYN56_RS20525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS20530	COG3275	phosphorelay sensor kinase activity
HYN56_RS20535	COG3279	Response regulator of the LytR AlgR family
HYN56_RS20545	COG2133	pyrroloquinoline quinone binding
HYN56_RS20605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYN56_RS20640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYN56_RS20645	COG4677	pectinesterase activity
HYN56_RS20650	COG1609	Transcriptional regulator
HYN56_RS20660	COG0800	Aldolase
HYN56_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS20670	COG1312	Catalyzes the dehydration of D-mannonate
HYN56_RS20680	COG3292	Two component regulator propeller
HYN56_RS20680	COG2205	protein histidine kinase activity
HYN56_RS20680	COG0745	RESPONSE REGULATOR receiver
HYN56_RS20685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYN56_RS20690	COG3250	beta-galactosidase activity
HYN56_RS20695	COG3250	beta-galactosidase activity
HYN56_RS20705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYN56_RS20710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HYN56_RS20715	COG2080	2 iron, 2 sulfur cluster binding
HYN56_RS20720	COG1104	cysteine desulfurase activity
HYN56_RS20730	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HYN56_RS20790	COG3250	beta-galactosidase activity
HYN56_RS20805	COG0702	epimerase
HYN56_RS20810	COG4771	TonB-dependent receptor
HYN56_RS20820	COG3292	Two component regulator propeller
HYN56_RS20820	COG2205	protein histidine kinase activity
HYN56_RS20820	COG0745	RESPONSE REGULATOR receiver
HYN56_RS20825	COG1556	Lactate utilization protein
HYN56_RS20830	COG1139	Iron-sulfur cluster binding protein
HYN56_RS20835	COG0247	lactate metabolic process
HYN56_RS20845	COG4952	isomerase
HYN56_RS20850	COG3347	Dehydrogenase
HYN56_RS20850	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS20865	COG2188	Transcriptional regulator
HYN56_RS20885	COG2755	lipolytic protein G-D-S-L family
HYN56_RS20895	COG4677	pectinesterase activity
HYN56_RS20905	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYN56_RS20910	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HYN56_RS20925	COG1609	Transcriptional regulator
HYN56_RS20930	COG2721	sulfolactate sulfo-lyase activity
HYN56_RS20935	COG0246	Mannitol dehydrogenase
HYN56_RS20950	COG1904	glucuronate isomerase
HYN56_RS20955	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS20960	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HYN56_RS20965	COG2271	Major facilitator Superfamily
HYN56_RS20970	COG2271	Major facilitator Superfamily
HYN56_RS20975	COG0657	acetylesterase activity
HYN56_RS20975	COG2755	lipolytic protein G-D-S-L family
HYN56_RS20990	COG4771	TonB-dependent receptor
HYN56_RS21015	COG1335	isochorismatase
HYN56_RS21020	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HYN56_RS21035	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HYN56_RS21040	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS21055	COG3279	Response regulator of the LytR AlgR family
HYN56_RS21075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS21110	COG0745	RESPONSE REGULATOR receiver
HYN56_RS21115	COG2205	protein histidine kinase activity
HYN56_RS21125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS21155	COG1704	LemA family
HYN56_RS21195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS21205	COG1538	Outer membrane efflux protein
HYN56_RS21245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYN56_RS21250	COG1127	ABC transporter
HYN56_RS21270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYN56_RS21315	COG1082	Xylose isomerase domain protein TIM barrel
HYN56_RS21330	COG4206	TonB-dependent receptor
HYN56_RS21330	COG1629	transport
HYN56_RS21355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYN56_RS21360	COG0697	spore germination
HYN56_RS21375	COG3012	SEC-C Motif Domain Protein
HYN56_RS21395	COG0484	heat shock protein binding
HYN56_RS21415	COG2814	Major facilitator Superfamily
HYN56_RS21430	COG1309	transcriptional regulator
HYN56_RS21465	COG4771	TonB-dependent receptor
HYN56_RS21470	COG0702	epimerase
HYN56_RS21475	COG1131	(ABC) transporter
HYN56_RS21485	COG0612	Peptidase, M16
HYN56_RS21505	COG0589	response to stress
HYN56_RS21505	COG0475	glutathione-regulated potassium exporter activity
HYN56_RS21550	COG3250	beta-galactosidase activity
HYN56_RS21560	COG3292	Two component regulator propeller
HYN56_RS21560	COG2205	protein histidine kinase activity
HYN56_RS21560	COG0745	RESPONSE REGULATOR receiver
HYN56_RS21600	COG4206	TonB-dependent receptor
HYN56_RS21600	COG1629	transport
HYN56_RS21610	COG1785	Belongs to the alkaline phosphatase family
HYN56_RS21620	COG4771	TonB-dependent receptor
HYN56_RS21625	COG2205	protein histidine kinase activity
HYN56_RS21625	COG3292	Two component regulator propeller
HYN56_RS21625	COG0745	RESPONSE REGULATOR receiver
HYN56_RS21635	COG2207	Transcriptional regulator
HYN56_RS21640	COG3384	dioxygenase
HYN56_RS21645	COG0596	Alpha beta hydrolase
HYN56_RS21665	COG2801	Transposase and inactivated derivatives
HYN56_RS21675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYN56_RS21685	COG0405	Gamma-glutamyltransferase
HYN56_RS21700	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYN56_RS21710	COG1611	Belongs to the LOG family
HYN56_RS21720	COG0022	dehydrogenase e1 component
HYN56_RS21725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HYN56_RS21730	COG2226	methyltransferase
HYN56_RS21735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYN56_RS21780	COG1301	dicarboxylic acid transport
HYN56_RS21795	COG1652	LysM domain
HYN56_RS21795	COG2823	Periplasmic or secreted lipoprotein
HYN56_RS21815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYN56_RS21835	COG0248	Ppx GppA phosphatase
HYN56_RS21840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HYN56_RS21865	COG3047	cAMP biosynthetic process
HYN56_RS21865	COG2885	chlorophyll binding
HYN56_RS21875	COG0259	pyridoxamine-phosphate oxidase activity
HYN56_RS21880	COG1234	tRNA 3'-trailer cleavage
HYN56_RS21890	COG0540	Belongs to the ATCase OTCase family
HYN56_RS21900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYN56_RS21915	COG0488	(ABC) transporter
HYN56_RS21950	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HYN56_RS21955	COG0363	glucosamine-6-phosphate deaminase activity
HYN56_RS21965	COG4771	TonB-dependent receptor
HYN56_RS21970	COG1404	Belongs to the peptidase S8 family
HYN56_RS21970	COG4935	Belongs to the peptidase S8 family
HYN56_RS21975	COG3275	phosphorelay sensor kinase activity
HYN56_RS21980	COG3279	Response regulator of the LytR AlgR family
HYN56_RS21995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYN56_RS22005	COG0300	oxidoreductase activity
HYN56_RS22020	COG1228	amidohydrolase
HYN56_RS22030	COG0010	Belongs to the arginase family
HYN56_RS22035	COG0513	Belongs to the DEAD box helicase family
HYN56_RS22045	COG1301	dicarboxylic acid transport
HYN56_RS22050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYN56_RS22070	COG0438	transferase activity, transferring glycosyl groups
HYN56_RS22085	COG0247	lactate metabolic process
HYN56_RS22085	COG2181	nitrate reductase activity
HYN56_RS22090	COG2181	nitrate reductase activity
HYN56_RS22090	COG0247	lactate metabolic process
HYN56_RS22100	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYN56_RS22100	COG1388	LysM domain
HYN56_RS22110	COG0251	oxidation-reduction process
HYN56_RS22130	COG0205	6-phosphofructokinase activity
HYN56_RS22140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYN56_RS22145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYN56_RS22165	COG0628	permease
HYN56_RS22225	COG2814	Major facilitator Superfamily
HYN56_RS22275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN56_RS22280	COG0463	Glycosyl transferase, family 2
HYN56_RS22295	COG0438	transferase activity, transferring glycosyl groups
HYN56_RS22335	COG1216	Glycosyl transferase, family 2
HYN56_RS22345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYN56_RS22350	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HYN56_RS22355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN56_RS22365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HYN56_RS22380	COG3620	sequence-specific DNA binding
HYN56_RS22400	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS22400	COG0300	oxidoreductase activity
HYN56_RS22400	COG3321	synthase
HYN56_RS22400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYN56_RS22400	COG0318	PFAM AMP-dependent synthetase and ligase
HYN56_RS22460	COG2885	chlorophyll binding
HYN56_RS22485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HYN56_RS22495	COG0584	glycerophosphoryl diester phosphodiesterase
HYN56_RS22510	COG4771	TonB-dependent receptor
HYN56_RS22545	COG0183	Belongs to the thiolase family
HYN56_RS22550	COG0791	NLP P60 protein
HYN56_RS22565	COG0667	Aldo Keto reductase
HYN56_RS22570	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYN56_RS22580	COG4106	trans-aconitate 2-methyltransferase activity
HYN56_RS22585	COG0583	DNA-binding transcription factor activity
HYN56_RS22600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYN56_RS22675	COG0243	molybdopterin cofactor binding
HYN56_RS22695	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYN56_RS22695	COG0315	cyclic pyranopterin monophosphate synthase activity
HYN56_RS22720	COG0746	molybdenum cofactor guanylyltransferase activity
HYN56_RS22730	COG0303	'Molybdopterin
HYN56_RS22735	COG1629	transport
HYN56_RS22740	COG0702	epimerase
HYN56_RS22755	COG3118	belongs to the thioredoxin family
HYN56_RS22760	COG3119	arylsulfatase activity
HYN56_RS22765	COG2855	membrane
HYN56_RS22770	COG1629	transport
HYN56_RS22775	COG0702	epimerase
HYN56_RS22785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYN56_RS22790	COG1522	sequence-specific DNA binding
HYN56_RS22805	COG2234	aminopeptidase activity
HYN56_RS22835	COG0101	tRNA pseudouridine synthase activity
HYN56_RS22840	COG1132	(ABC) transporter
HYN56_RS22845	COG3275	phosphorelay sensor kinase activity
HYN56_RS22855	COG4206	TonB-dependent receptor
HYN56_RS22855	COG1629	transport
HYN56_RS22860	COG0702	epimerase
HYN56_RS22865	COG3279	Response regulator of the LytR AlgR family
HYN56_RS22875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYN56_RS22925	COG3655	Transcriptional regulator
HYN56_RS22930	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYN56_RS22955	COG1917	Cupin 2, conserved barrel domain protein
HYN56_RS22955	COG4977	sequence-specific DNA binding
HYN56_RS22990	COG2706	6-phosphogluconolactonase activity
HYN56_RS23000	COG1611	Belongs to the LOG family
HYN56_RS23035	COG0475	glutathione-regulated potassium exporter activity
HYN56_RS23035	COG0589	response to stress
HYN56_RS23040	COG1760	l-serine dehydratase
HYN56_RS23050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYN56_RS23055	COG0564	pseudouridine synthase activity
HYN56_RS23060	COG1012	belongs to the aldehyde dehydrogenase family
HYN56_RS23070	COG0784	Response regulator, receiver
HYN56_RS23070	COG5002	protein histidine kinase activity
HYN56_RS23070	COG2205	protein histidine kinase activity
HYN56_RS23075	COG2321	neutral zinc metallopeptidase
HYN56_RS23085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYN56_RS23090	COG1169	isochorismate synthase
HYN56_RS23105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYN56_RS23105	COG0047	phosphoribosylformylglycinamidine synthase activity
HYN56_RS23125	COG1022	Amp-dependent synthetase and ligase
HYN56_RS23145	COG0714	Associated with various cellular activities
HYN56_RS23190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HYN56_RS23195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYN56_RS23265	COG0084	hydrolase, TatD family'
HYN56_RS23315	COG1024	Enoyl-CoA hydratase
HYN56_RS23315	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYN56_RS23325	COG0183	Belongs to the thiolase family
HYN56_RS23330	COG1960	acyl-CoA dehydrogenase activity
HYN56_RS23370	COG0288	reversible hydration of carbon dioxide
HYN56_RS23390	COG0583	DNA-binding transcription factor activity
HYN56_RS23400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYN56_RS23400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HYN56_RS23410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYN56_RS23430	COG1595	DNA-templated transcription, initiation
HYN56_RS23455	COG3158	transport of potassium into the cell
HYN56_RS23460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYN56_RS23460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYN56_RS23475	COG1393	Belongs to the ArsC family
HYN56_RS23500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYN56_RS23510	COG0667	Aldo Keto reductase
HYN56_RS23525	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS23535	COG4221	oxidoreductase activity
HYN56_RS23555	COG3279	Response regulator of the LytR AlgR family
HYN56_RS23560	COG4251	negative regulation of phosphorylation
HYN56_RS23570	COG3781	membrane
HYN56_RS23580	COG1104	cysteine desulfurase activity
HYN56_RS23585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS23600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYN56_RS23620	COG2011	ABC-type metal ion transport system permease component
HYN56_RS23640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYN56_RS23680	COG0612	Peptidase, M16
HYN56_RS23685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN56_RS23715	COG4771	TonB-dependent receptor
HYN56_RS23750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYN56_RS23760	COG0784	Response regulator, receiver
HYN56_RS23765	COG4251	negative regulation of phosphorylation
HYN56_RS23820	COG2723	6-phospho-beta-galactosidase activity
HYN56_RS23850	COG1349	DNA-binding transcription factor activity
HYN56_RS23925	COG1538	Outer membrane efflux protein
HYN56_RS23935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN56_RS23990	COG1395	domain, Protein
HYN56_RS24000	COG1294	oxidase, subunit
HYN56_RS24005	COG1271	oxidase subunit
HYN56_RS24015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYN56_RS24015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYN56_RS24030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYN56_RS24040	COG0778	Nitroreductase
HYN56_RS24065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYN56_RS24075	COG0512	Glutamine amidotransferase of anthranilate synthase
HYN56_RS24075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYN56_RS24080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYN56_RS24085	COG0134	indole-3-glycerol-phosphate synthase activity
HYN56_RS24090	COG0135	phosphoribosylanthranilate isomerase activity
HYN56_RS24095	COG0133	tryptophan synthase activity
HYN56_RS24105	COG0159	tryptophan synthase activity
HYN56_RS24110	COG1309	transcriptional regulator
HYN56_RS24130	COG3022	response to hydroperoxide
HYN56_RS24135	COG0617	tRNA 3'-terminal CCA addition
HYN56_RS24135	COG0517	IMP dehydrogenase activity
HYN56_RS24135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYN56_RS24140	COG1612	heme a metabolic process
HYN56_RS24145	COG3279	Response regulator of the LytR AlgR family
HYN56_RS24170	COG3275	phosphorelay sensor kinase activity
HYN56_RS24195	COG0110	maltose O-acetyltransferase activity
HYN56_RS24200	COG0346	lactoylglutathione lyase activity
HYN56_RS24230	COG1309	transcriptional regulator
HYN56_RS24235	COG1028	Short-chain dehydrogenase reductase Sdr
HYN56_RS24265	COG1131	(ABC) transporter
HYN56_RS24285	COG1217	gtp-binding protein TYPA
HYN56_RS24290	COG5002	protein histidine kinase activity
HYN56_RS24295	COG2201	protein-glutamate methylesterase activity
HYN56_RS24300	COG0268	Binds directly to 16S ribosomal RNA
HYN56_RS24315	COG0442	prolyl-tRNA aminoacylation
HYN56_RS24330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYN56_RS24355	COG3345	alpha-galactosidase
HYN56_RS24370	COG0561	phosphatase activity
HYN56_RS24375	COG4771	TonB-dependent receptor
HYN56_RS24380	COG2169	Transcriptional regulator
HYN56_RS24385	COG4124	Belongs to the glycosyl hydrolase 26 family
HYN56_RS24390	COG2211	Major facilitator Superfamily
HYN56_RS24395	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYN56_RS24400	COG2942	2-epimerase
HYN56_RS24420	COG4948	Mandelate Racemase Muconate Lactonizing
HYN56_RS24425	COG0667	Aldo Keto reductase
HYN56_RS24430	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN56_RS24440	COG2755	lipolytic protein G-D-S-L family
HYN56_RS24445	COG0791	NLP P60 protein
HYN56_RS24505	COG0640	Transcriptional regulator
HYN56_RS24510	COG0477	Major facilitator Superfamily
HYN56_RS24515	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HYN56_RS24525	COG0105	UTP biosynthetic process
HYN56_RS24545	COG0552	protein localization to endoplasmic reticulum
HYN56_RS24555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYN56_RS24560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYN56_RS24565	COG1058	Belongs to the CinA family
HYN56_RS24565	COG1546	Belongs to the CinA family
HYN56_RS24575	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYN56_RS24585	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYN56_RS24590	COG1215	transferase activity, transferring glycosyl groups
HYN56_RS24610	COG4464	protein tyrosine phosphatase activity
HYN56_RS24645	COG0110	maltose O-acetyltransferase activity
HYN56_RS24685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HYN56_RS24695	COG0488	(ABC) transporter
HYN56_RS24700	COG0545	Peptidyl-prolyl cis-trans isomerase
HYN56_RS24715	COG1136	(ABC) transporter
HYN56_RS24730	COG0653	protein targeting
HYN56_RS24735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYN56_RS24740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYN56_RS24750	COG4651	solute:proton antiporter activity
HYN56_RS24750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYN56_RS24755	COG0450	alkyl hydroperoxide reductase
HYN56_RS24790	COG1368	sulfuric ester hydrolase activity
HYN56_RS24800	COG0534	Mate efflux family protein
HYN56_RS24810	COG2326	polyphosphate kinase activity
HYN56_RS24825	COG1595	DNA-templated transcription, initiation
HYN56_RS24830	COG4771	TonB-dependent receptor
HYN56_RS24835	COG2304	oxidoreductase activity
HYN56_RS24845	COG0300	oxidoreductase activity
HYN56_RS24855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYN56_RS24870	COG0561	phosphatase activity
HYN56_RS24880	COG1073	alpha beta
HYN56_RS24885	COG0513	Belongs to the DEAD box helicase family
HYN56_RS24890	COG2204	response regulator
HYN56_RS24900	COG4152	abc transporter atp-binding protein
HYN56_RS24905	COG0484	heat shock protein binding
HYN56_RS24910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYN56_RS24925	COG0124	histidyl-tRNA synthetase
HYN56_RS24930	COG0577	efflux transmembrane transporter activity
HYN56_RS24935	COG2890	protein-(glutamine-N5) methyltransferase activity
HYN56_RS24945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYN56_RS24945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYN56_RS24950	COG1011	Hydrolase
HYN56_RS24955	COG1739	Uncharacterized protein family UPF0029
HYN56_RS24960	COG0824	Thioesterase