locus-tag	class	description
HYN59_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYN59_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYN59_RS00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYN59_RS00020	COG2304	oxidoreductase activity
HYN59_RS00035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYN59_RS00045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HYN59_RS00050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYN59_RS00065	COG2204	response regulator
HYN59_RS00075	COG4152	abc transporter atp-binding protein
HYN59_RS00080	COG0484	heat shock protein binding
HYN59_RS00085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYN59_RS00090	COG1090	epimerase
HYN59_RS00140	COG0492	ferredoxin-NADP+ reductase activity
HYN59_RS00205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYN59_RS00215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYN59_RS00225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYN59_RS00245	COG1595	DNA-templated transcription, initiation
HYN59_RS00255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYN59_RS00270	COG1663	tetraacyldisaccharide 4'-kinase activity
HYN59_RS00280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYN59_RS00295	COG4935	Belongs to the peptidase S8 family
HYN59_RS00295	COG1404	Belongs to the peptidase S8 family
HYN59_RS00300	COG1187	pseudouridine synthase activity
HYN59_RS00320	COG0300	oxidoreductase activity
HYN59_RS00325	COG3386	PFAM SMP-30 Gluconolaconase
HYN59_RS00330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HYN59_RS00335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYN59_RS00350	COG2201	protein-glutamate methylesterase activity
HYN59_RS00355	COG5002	protein histidine kinase activity
HYN59_RS00360	COG4974	Belongs to the 'phage' integrase family
HYN59_RS00395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYN59_RS00400	COG1629	transport
HYN59_RS00405	COG1690	Belongs to the RtcB family
HYN59_RS00455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYN59_RS00535	COG0514	ATP-dependent DNA helicase (RecQ)
HYN59_RS00540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYN59_RS00550	COG1678	Uncharacterized ACR, COG1678
HYN59_RS00595	COG3275	phosphorelay sensor kinase activity
HYN59_RS00600	COG3279	Response regulator of the LytR AlgR family
HYN59_RS00650	COG1696	Membrane protein involved in D-alanine export
HYN59_RS00655	COG0791	NLP P60 protein
HYN59_RS00655	COG1388	LysM domain
HYN59_RS00665	COG0018	arginyl-trna synthetase
HYN59_RS00685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYN59_RS00690	COG1506	peptidase
HYN59_RS00705	COG3842	ATPase activity
HYN59_RS00780	COG0326	Molecular chaperone. Has ATPase activity
HYN59_RS00790	COG2885	chlorophyll binding
HYN59_RS00790	COG3047	cAMP biosynthetic process
HYN59_RS00830	COG1482	cell wall glycoprotein biosynthetic process
HYN59_RS00840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HYN59_RS00845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYN59_RS00865	COG3012	SEC-C Motif Domain Protein
HYN59_RS00885	COG2942	2-epimerase
HYN59_RS00890	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYN59_RS00895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYN59_RS00900	COG4124	Belongs to the glycosyl hydrolase 26 family
HYN59_RS00905	COG2169	Transcriptional regulator
HYN59_RS00910	COG4771	TonB-dependent receptor
HYN59_RS00915	COG0561	phosphatase activity
HYN59_RS00925	COG3345	alpha-galactosidase
HYN59_RS00940	COG4585	Histidine kinase
HYN59_RS00970	COG2095	MarC family integral membrane protein
HYN59_RS01005	COG0175	sulfate reduction
HYN59_RS01010	COG1959	2 iron, 2 sulfur cluster binding
HYN59_RS01025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYN59_RS01045	COG3279	Response regulator of the LytR AlgR family
HYN59_RS01050	COG3275	phosphorelay sensor kinase activity
HYN59_RS01065	COG0148	phosphopyruvate hydratase activity
HYN59_RS01070	COG0505	Belongs to the CarA family
HYN59_RS01075	COG0203	ribosomal protein L17
HYN59_RS01080	COG0202	RNA polymerase activity
HYN59_RS01085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYN59_RS01090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYN59_RS01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYN59_RS01100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYN59_RS01105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYN59_RS01115	COG0200	Binds to the 23S rRNA
HYN59_RS01120	COG1841	ribosomal large subunit assembly
HYN59_RS01125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYN59_RS01130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYN59_RS01135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYN59_RS01140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYN59_RS01145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYN59_RS01150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HYN59_RS01155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYN59_RS01160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYN59_RS01165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYN59_RS01170	COG0255	Belongs to the universal ribosomal protein uL29 family
HYN59_RS01175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYN59_RS01180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYN59_RS01185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HYN59_RS01190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYN59_RS01195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYN59_RS01200	COG0089	rRNA binding
HYN59_RS01205	COG0088	Forms part of the polypeptide exit tunnel
HYN59_RS01210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HYN59_RS01215	COG0051	transcription antitermination factor activity, RNA binding
HYN59_RS01220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYN59_RS01225	COG0049	tRNA binding
HYN59_RS01230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYN59_RS01240	COG4206	TonB-dependent receptor
HYN59_RS01240	COG1629	transport
HYN59_RS01260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYN59_RS01265	COG3540	Alkaline phosphatase
HYN59_RS01275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYN59_RS01285	COG1011	Hydrolase
HYN59_RS01300	COG1136	(ABC) transporter
HYN59_RS01310	COG1064	alcohol dehydrogenase
HYN59_RS01320	COG2003	Belongs to the UPF0758 family
HYN59_RS01325	COG3738	Protein conserved in bacteria
HYN59_RS01335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYN59_RS01350	COG3591	Belongs to the peptidase S1B family
HYN59_RS01370	COG3279	Response regulator of the LytR AlgR family
HYN59_RS01375	COG1652	LysM domain
HYN59_RS01385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYN59_RS01390	COG1253	flavin adenine dinucleotide binding
HYN59_RS01405	COG4772	TonB-dependent receptor
HYN59_RS01415	COG1301	dicarboxylic acid transport
HYN59_RS01425	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYN59_RS01430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYN59_RS01435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYN59_RS01445	COG0339	signal peptide processing
HYN59_RS01455	COG1510	regulation of RNA biosynthetic process
HYN59_RS01485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYN59_RS01500	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYN59_RS01500	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYN59_RS01515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYN59_RS01530	COG1215	transferase activity, transferring glycosyl groups
HYN59_RS01535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYN59_RS01540	COG1127	ABC transporter
HYN59_RS01565	COG0300	oxidoreductase activity
HYN59_RS01575	COG1733	regulation of RNA biosynthetic process
HYN59_RS01580	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS01600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYN59_RS01610	COG0295	cytidine deaminase activity
HYN59_RS01625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYN59_RS01630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYN59_RS01660	COG2267	carboxylic ester hydrolase activity
HYN59_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS01720	COG0577	efflux transmembrane transporter activity
HYN59_RS01725	COG3876	Protein conserved in bacteria
HYN59_RS01750	COG2813	Specifically methylates the guanine in position
HYN59_RS01755	COG0602	queuosine metabolic process
HYN59_RS01795	COG0811	peptide transport
HYN59_RS01805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYN59_RS01805	COG0662	Cupin 2, conserved barrel domain protein
HYN59_RS01810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYN59_RS01820	COG0671	phosphoesterase, PA-phosphatase related
HYN59_RS01835	COG0745	RESPONSE REGULATOR receiver
HYN59_RS01840	COG5002	protein histidine kinase activity
HYN59_RS01850	COG1368	sulfuric ester hydrolase activity
HYN59_RS01860	COG0671	phosphoesterase, PA-phosphatase related
HYN59_RS01865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYN59_RS01885	COG1610	YqeY-like protein
HYN59_RS01890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYN59_RS01905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYN59_RS01910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYN59_RS01915	COG0772	Belongs to the SEDS family
HYN59_RS01920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYN59_RS01925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYN59_RS01930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYN59_RS01945	COG0275	rRNA processing
HYN59_RS01950	COG2001	Belongs to the MraZ family
HYN59_RS01965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYN59_RS01970	COG0454	-acetyltransferase
HYN59_RS01985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYN59_RS01990	COG2197	response regulator
HYN59_RS01995	COG0358	DNA primase activity
HYN59_RS02000	COG1214	PFAM Peptidase M22, glycoprotease
HYN59_RS02025	COG2322	membrane
HYN59_RS02030	COG1999	signal sequence binding
HYN59_RS02050	COG1845	cytochrome c oxidase, subunit III
HYN59_RS02055	COG0109	protoheme IX farnesyltransferase activity
HYN59_RS02060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYN59_RS02070	COG0509	glycine decarboxylation via glycine cleavage system
HYN59_RS02080	COG0632	four-way junction helicase activity
HYN59_RS02090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYN59_RS02095	COG2255	four-way junction helicase activity
HYN59_RS02110	COG0531	amino acid
HYN59_RS02120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYN59_RS02150	COG0437	4 iron, 4 sulfur cluster binding
HYN59_RS02165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYN59_RS02170	COG2251	uridine kinase activity
HYN59_RS02170	COG0195	Participates in both transcription termination and antitermination
HYN59_RS02175	COG0779	Required for maturation of 30S ribosomal subunits
HYN59_RS02215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYN59_RS02215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYN59_RS02220	COG1408	metallophosphoesterase
HYN59_RS02320	COG2315	Protein conserved in bacteria
HYN59_RS02335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYN59_RS02340	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HYN59_RS02370	COG1733	regulation of RNA biosynthetic process
HYN59_RS02375	COG3118	belongs to the thioredoxin family
HYN59_RS02395	COG0228	four-way junction DNA binding
HYN59_RS02400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYN59_RS02405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYN59_RS02435	COG1960	acyl-CoA dehydrogenase activity
HYN59_RS02460	COG3275	phosphorelay sensor kinase activity
HYN59_RS02465	COG3279	Response regulator of the LytR AlgR family
HYN59_RS02475	COG0633	Ferredoxin
HYN59_RS02480	COG0492	ferredoxin-NADP+ reductase activity
HYN59_RS02490	COG0489	protein tyrosine kinase activity
HYN59_RS02505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYN59_RS02510	COG5002	protein histidine kinase activity
HYN59_RS02515	COG0745	RESPONSE REGULATOR receiver
HYN59_RS02550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYN59_RS02590	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HYN59_RS02610	COG1522	sequence-specific DNA binding
HYN59_RS02620	COG0495	leucyl-tRNA aminoacylation
HYN59_RS02625	COG2177	Part of the ABC transporter FtsEX involved in
HYN59_RS02635	COG1968	undecaprenyl-diphosphatase activity
HYN59_RS02640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYN59_RS02670	COG0233	cytoplasmic translational termination
HYN59_RS02690	COG2076	Multidrug Resistance protein
HYN59_RS02695	COG0017	Asparaginyl-tRNA synthetase
HYN59_RS02705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYN59_RS02725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYN59_RS02750	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HYN59_RS02765	COG0673	inositol 2-dehydrogenase activity
HYN59_RS02785	COG0025	NhaP-type Na H and K H
HYN59_RS02790	COG0657	acetylesterase activity
HYN59_RS02790	COG2755	lipolytic protein G-D-S-L family
HYN59_RS02835	COG0252	asparaginase activity
HYN59_RS02845	COG0084	hydrolase, TatD family'
HYN59_RS02860	COG0567	Dehydrogenase, E1 component
HYN59_RS02910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN59_RS02925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYN59_RS02930	COG0297	glycogen (starch) synthase activity
HYN59_RS02950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN59_RS02955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN59_RS02965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYN59_RS02970	COG1278	Cold shock
HYN59_RS02975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN59_RS02980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN59_RS02985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN59_RS02990	COG0649	NAD binding
HYN59_RS02995	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HYN59_RS03005	COG1034	ATP synthesis coupled electron transport
HYN59_RS03010	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HYN59_RS03015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN59_RS03020	COG0839	Belongs to the complex I subunit 6 family
HYN59_RS03025	COG0713	ATP synthesis coupled electron transport
HYN59_RS03030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYN59_RS03035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYN59_RS03040	COG1007	ATP synthesis coupled electron transport
HYN59_RS03045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYN59_RS03060	COG0527	aspartate kinase activity
HYN59_RS03070	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HYN59_RS03090	COG0793	Belongs to the peptidase S41A family
HYN59_RS03155	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HYN59_RS03175	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN59_RS03190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYN59_RS03190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYN59_RS03220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYN59_RS03255	COG1970	mechanosensitive ion channel activity
HYN59_RS03260	COG1063	alcohol dehydrogenase
HYN59_RS03265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYN59_RS03300	COG1505	serine-type exopeptidase activity
HYN59_RS03310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYN59_RS03325	COG4733	cellulase activity
HYN59_RS03325	COG5297	Belongs to the glycosyl hydrolase family 6
HYN59_RS03330	COG1301	dicarboxylic acid transport
HYN59_RS03335	COG0586	Pfam SNARE associated Golgi protein
HYN59_RS03350	COG1506	peptidase
HYN59_RS03350	COG0823	Involved in the tonB-independent uptake of proteins
HYN59_RS03385	COG0439	Biotin carboxylase
HYN59_RS03390	COG0511	ligase activity, forming carbon-carbon bonds
HYN59_RS03395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYN59_RS03400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYN59_RS03410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HYN59_RS03495	COG0346	lactoylglutathione lyase activity
HYN59_RS03500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYN59_RS03540	COG0481	GTPase activity
HYN59_RS03555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN59_RS03570	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HYN59_RS03585	COG0423	glycine-tRNA ligase activity
HYN59_RS03590	COG1040	competence protein
HYN59_RS03610	COG5520	Belongs to the glycosyl hydrolase 30 family
HYN59_RS03625	COG3425	synthase
HYN59_RS03640	COG0006	proline dipeptidase activity
HYN59_RS03660	COG2885	chlorophyll binding
HYN59_RS03665	COG0156	8-amino-7-oxononanoate synthase activity
HYN59_RS03670	COG1074	ATP-dependent DNA helicase activity
HYN59_RS03705	COG0328	RNA-DNA hybrid ribonuclease activity
HYN59_RS03715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYN59_RS03720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYN59_RS03725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYN59_RS03730	COG0571	ribonuclease III activity
HYN59_RS03750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYN59_RS03760	COG2954	triphosphatase activity
HYN59_RS03765	COG0492	ferredoxin-NADP+ reductase activity
HYN59_RS03785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYN59_RS03795	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYN59_RS03800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYN59_RS03810	COG0166	Belongs to the GPI family
HYN59_RS03820	COG3483	tryptophan 2,3-dioxygenase activity
HYN59_RS03830	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HYN59_RS03835	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HYN59_RS03840	COG0531	amino acid
HYN59_RS03845	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYN59_RS03850	COG0322	excinuclease ABC activity
HYN59_RS03860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYN59_RS03865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYN59_RS03875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYN59_RS03890	COG3279	Response regulator of the LytR AlgR family
HYN59_RS03895	COG4251	negative regulation of phosphorylation
HYN59_RS03945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HYN59_RS03950	COG1733	regulation of RNA biosynthetic process
HYN59_RS03960	COG0004	ammonium transporteR
HYN59_RS03990	COG1053	succinate dehydrogenase
HYN59_RS03995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYN59_RS04015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYN59_RS04050	COG2304	oxidoreductase activity
HYN59_RS04055	COG2304	oxidoreductase activity
HYN59_RS04075	COG0714	Associated with various cellular activities
HYN59_RS04080	COG4989	oxidoreductase activity
HYN59_RS04085	COG4221	oxidoreductase activity
HYN59_RS04105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYN59_RS04120	COG1690	Belongs to the RtcB family
HYN59_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS04140	COG1012	belongs to the aldehyde dehydrogenase family
HYN59_RS04145	COG0598	Magnesium transport protein CorA
HYN59_RS04195	COG0720	synthase
HYN59_RS04215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYN59_RS04225	COG2814	Major facilitator Superfamily
HYN59_RS04240	COG2151	metal-sulfur cluster biosynthetic enzyme
HYN59_RS04245	COG2166	iron-sulfur cluster assembly
HYN59_RS04255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYN59_RS04265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYN59_RS04270	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HYN59_RS04275	COG3720	iron ion transport
HYN59_RS04280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYN59_RS04295	COG4206	TonB-dependent receptor
HYN59_RS04300	COG0719	Fe-S assembly protein
HYN59_RS04310	COG0396	ATPase activity
HYN59_RS04325	COG0719	Fe-S assembly protein
HYN59_RS04330	COG0316	Belongs to the HesB IscA family
HYN59_RS04340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYN59_RS04375	COG0594	ribonuclease P activity
HYN59_RS04380	COG0793	Belongs to the peptidase S41A family
HYN59_RS04385	COG3158	transport of potassium into the cell
HYN59_RS04390	COG2885	chlorophyll binding
HYN59_RS04395	COG2153	protein acetylation
HYN59_RS04405	COG4932	domain protein
HYN59_RS04405	COG1388	LysM domain
HYN59_RS04410	COG0126	phosphoglycerate kinase activity
HYN59_RS04415	COG0470	DNA polymerase III
HYN59_RS04435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYN59_RS04455	COG0445	tRNA wobble uridine modification
HYN59_RS04460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYN59_RS04470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYN59_RS04470	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HYN59_RS04525	COG3177	Filamentation induced by cAMP protein fic
HYN59_RS04535	COG0557	exoribonuclease II activity
HYN59_RS04545	COG0698	ribose 5-phosphate isomerase
HYN59_RS04565	COG2183	response to ionizing radiation
HYN59_RS04575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYN59_RS04580	COG4942	peptidase
HYN59_RS04660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HYN59_RS04690	COG0151	Belongs to the GarS family
HYN59_RS04705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYN59_RS04715	COG0859	PFAM glycosyl transferase family 9
HYN59_RS04720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYN59_RS04750	COG0457	Tetratricopeptide repeat
HYN59_RS04770	COG0356	it plays a direct role in the translocation of protons across the membrane
HYN59_RS04775	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYN59_RS04780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HYN59_RS04785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYN59_RS04790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYN59_RS04795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYN59_RS04805	COG1505	serine-type exopeptidase activity
HYN59_RS04815	COG0756	dUTP diphosphatase activity
HYN59_RS04820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYN59_RS04850	COG1607	acyl-coa hydrolase
HYN59_RS04860	COG0758	DNA mediated transformation
HYN59_RS04860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYN59_RS04865	COG0180	Tryptophanyl-tRNA synthetase
HYN59_RS04890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HYN59_RS04905	COG1054	Belongs to the UPF0176 family
HYN59_RS04915	COG1774	PSP1 C-terminal conserved region
HYN59_RS04930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYN59_RS04960	COG3158	transport of potassium into the cell
HYN59_RS04990	COG1476	TRANSCRIPTIONal
HYN59_RS05020	COG0113	porphobilinogen synthase activity
HYN59_RS05030	COG0408	coproporphyrinogen oxidase activity
HYN59_RS05035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYN59_RS05045	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYN59_RS05055	COG0181	hydroxymethylbilane synthase activity
HYN59_RS05060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HYN59_RS05075	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYN59_RS05080	COG0534	Mate efflux family protein
HYN59_RS05085	COG1981	membrane
HYN59_RS05090	COG5000	phosphorelay sensor kinase activity
HYN59_RS05095	COG1024	Enoyl-CoA hydratase
HYN59_RS05110	COG4682	membrane
HYN59_RS05135	COG1418	mRNA catabolic process
HYN59_RS05180	COG4941	Belongs to the sigma-70 factor family
HYN59_RS05200	COG1999	signal sequence binding
HYN59_RS05205	COG3590	peptidase
HYN59_RS05225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYN59_RS05225	COG3153	acetyltransferase
HYN59_RS05240	COG0629	single-stranded DNA binding
HYN59_RS05245	COG4221	oxidoreductase activity
HYN59_RS05250	COG1917	Cupin 2, conserved barrel domain protein
HYN59_RS05250	COG4977	sequence-specific DNA binding
HYN59_RS05255	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYN59_RS05275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYN59_RS05275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYN59_RS05290	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYN59_RS05295	COG0792	nuclease activity
HYN59_RS05315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYN59_RS05325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN59_RS05335	COG3537	Alpha-1,2-mannosidase
HYN59_RS05340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HYN59_RS05345	COG1979	alcohol dehydrogenase
HYN59_RS05350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYN59_RS05355	COG0194	GDP metabolic process
HYN59_RS05385	COG0626	cystathionine gamma-synthase activity
HYN59_RS05390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYN59_RS05400	COG1381	Involved in DNA repair and RecF pathway recombination
HYN59_RS05430	COG0750	zinc metalloprotease
HYN59_RS05440	COG0673	inositol 2-dehydrogenase activity
HYN59_RS05445	COG0667	Aldo Keto reductase
HYN59_RS05450	COG4297	protein containing double-stranded beta helix domain
HYN59_RS05470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYN59_RS05485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYN59_RS05490	COG2239	Acts as a magnesium transporter
HYN59_RS05495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYN59_RS05500	COG3152	Membrane
HYN59_RS05510	COG0708	Exodeoxyribonuclease III
HYN59_RS05515	COG1360	Flagellar Motor Protein
HYN59_RS05525	COG1629	transport
HYN59_RS05530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYN59_RS05535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYN59_RS05550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HYN59_RS05555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYN59_RS05560	COG0297	glycogen (starch) synthase activity
HYN59_RS05570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYN59_RS05580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYN59_RS05605	COG3655	Transcriptional regulator
HYN59_RS05625	COG0156	8-amino-7-oxononanoate synthase activity
HYN59_RS05635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HYN59_RS05640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYN59_RS05650	COG0193	aminoacyl-tRNA hydrolase activity
HYN59_RS05665	COG0196	riboflavin kinase activity
HYN59_RS05680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYN59_RS05745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYN59_RS05750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYN59_RS05795	COG2723	6-phospho-beta-galactosidase activity
HYN59_RS05805	COG3292	Two component regulator propeller
HYN59_RS05805	COG0745	RESPONSE REGULATOR receiver
HYN59_RS05805	COG3292	Two component regulator propeller
HYN59_RS05805	COG2205	protein histidine kinase activity
HYN59_RS05805	COG2205	protein histidine kinase activity
HYN59_RS05805	COG0745	RESPONSE REGULATOR receiver
HYN59_RS05810	COG3852	Histidine kinase
HYN59_RS05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYN59_RS05835	COG1082	Xylose isomerase domain protein TIM barrel
HYN59_RS05840	COG2860	membrane
HYN59_RS05865	COG0577	efflux transmembrane transporter activity
HYN59_RS05865	COG1136	(ABC) transporter
HYN59_RS05890	COG0561	phosphatase activity
HYN59_RS05915	COG1858	cytochrome C peroxidase
HYN59_RS05930	COG2814	Major facilitator Superfamily
HYN59_RS05960	COG2095	MarC family integral membrane protein
HYN59_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYN59_RS05975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYN59_RS05990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HYN59_RS06000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYN59_RS06010	COG0590	tRNA wobble adenosine to inosine editing
HYN59_RS06035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HYN59_RS06040	COG2814	Major facilitator Superfamily
HYN59_RS06150	COG3275	phosphorelay sensor kinase activity
HYN59_RS06155	COG3279	Response regulator of the LytR AlgR family
HYN59_RS06170	COG0300	oxidoreductase activity
HYN59_RS06205	COG1530	ribonuclease E activity
HYN59_RS06250	COG0612	Peptidase, M16
HYN59_RS06255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYN59_RS06260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYN59_RS06275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HYN59_RS06295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYN59_RS06300	COG3852	Histidine kinase
HYN59_RS06325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYN59_RS06355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HYN59_RS06375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HYN59_RS06390	COG0519	Catalyzes the synthesis of GMP from XMP
HYN59_RS06410	COG0686	Belongs to the AlaDH PNT family
HYN59_RS06415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYN59_RS06420	COG0052	Belongs to the universal ribosomal protein uS2 family
HYN59_RS06425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYN59_RS06430	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYN59_RS06455	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYN59_RS06465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HYN59_RS06470	COG1629	transport
HYN59_RS06470	COG4206	TonB-dependent receptor
HYN59_RS06475	COG1609	Transcriptional regulator
HYN59_RS06480	COG2211	Major facilitator Superfamily
HYN59_RS06480	COG2190	(PTS) system
HYN59_RS06485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYN59_RS06490	COG1554	hydrolase, family 65, central catalytic
HYN59_RS06495	COG0366	Alpha amylase catalytic
HYN59_RS06500	COG0366	Alpha amylase catalytic
HYN59_RS06510	COG0366	Alpha amylase catalytic
HYN59_RS06520	COG0584	glycerophosphoryl diester phosphodiesterase
HYN59_RS06525	COG2081	HI0933 family
HYN59_RS06540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYN59_RS06550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYN59_RS06555	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HYN59_RS06590	COG1187	pseudouridine synthase activity
HYN59_RS06600	COG0339	signal peptide processing
HYN59_RS06625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HYN59_RS06630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYN59_RS06650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYN59_RS06660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYN59_RS06670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HYN59_RS06675	COG2267	carboxylic ester hydrolase activity
HYN59_RS06700	COG1950	PFAM Membrane protein of
HYN59_RS06705	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYN59_RS06715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HYN59_RS06750	COG0616	signal peptide processing
HYN59_RS06755	COG1428	Deoxynucleoside kinase
HYN59_RS06765	COG0546	phosphoglycolate phosphatase activity
HYN59_RS06785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYN59_RS06795	COG3781	membrane
HYN59_RS06805	COG3850	Histidine kinase
HYN59_RS06805	COG5002	protein histidine kinase activity
HYN59_RS06810	COG0745	RESPONSE REGULATOR receiver
HYN59_RS06820	COG4717	serine-type aminopeptidase activity
HYN59_RS06845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYN59_RS06850	COG0456	acetyltransferase
HYN59_RS06855	COG1519	Transferase
HYN59_RS06855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYN59_RS06865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYN59_RS06870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYN59_RS06895	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HYN59_RS06905	COG2161	toxin-antitoxin pair type II binding
HYN59_RS06910	COG0436	Aminotransferase
HYN59_RS06915	COG3239	Fatty acid desaturase
HYN59_RS06920	COG0357	Ribosomal RNA small subunit methyltransferase G
HYN59_RS06950	COG1012	belongs to the aldehyde dehydrogenase family
HYN59_RS06960	COG2967	ApaG domain
HYN59_RS06985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HYN59_RS06995	COG2989	Protein conserved in bacteria
HYN59_RS07010	COG3340	Belongs to the peptidase S51 family
HYN59_RS07015	COG1629	transport
HYN59_RS07055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYN59_RS07060	COG0671	phosphoesterase, PA-phosphatase related
HYN59_RS07080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYN59_RS07120	COG1331	Highly conserved protein containing a thioredoxin domain
HYN59_RS07280	COG3179	chitinase
HYN59_RS07295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYN59_RS07320	COG1253	flavin adenine dinucleotide binding
HYN59_RS07340	COG0823	Involved in the tonB-independent uptake of proteins
HYN59_RS07340	COG1506	peptidase
HYN59_RS07345	COG3104	oligopeptide transport
HYN59_RS07360	COG0658	competence protein
HYN59_RS07360	COG2333	competence protein COMEC
HYN59_RS07365	COG0791	NLP P60 protein
HYN59_RS07370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN59_RS07385	COG3201	nicotinamide mononucleotide transporter
HYN59_RS07400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HYN59_RS07405	COG0793	Belongs to the peptidase S41A family
HYN59_RS07410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYN59_RS07420	COG0772	Belongs to the SEDS family
HYN59_RS07425	COG0768	penicillin binding
HYN59_RS07440	COG1077	Cell shape determining protein MreB Mrl
HYN59_RS07445	COG0138	bifunctional purine biosynthesis protein purh
HYN59_RS07450	COG0577	efflux transmembrane transporter activity
HYN59_RS07450	COG1136	(ABC) transporter
HYN59_RS07455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYN59_RS07490	COG2226	methyltransferase
HYN59_RS07535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HYN59_RS07545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYN59_RS07550	COG2086	electron transfer activity
HYN59_RS07555	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYN59_RS07555	COG0022	dehydrogenase e1 component
HYN59_RS07575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYN59_RS07580	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HYN59_RS07585	COG1428	Deoxynucleoside kinase
HYN59_RS07615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYN59_RS07635	COG0646	methionine synthase
HYN59_RS07635	COG1410	methionine synthase
HYN59_RS07645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYN59_RS07680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYN59_RS07690	COG1162	GTPase activity
HYN59_RS07695	COG1490	D-aminoacyl-tRNA deacylase activity
HYN59_RS07720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYN59_RS07725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYN59_RS07735	COG3844	kynureninase activity
HYN59_RS07775	COG4977	sequence-specific DNA binding
HYN59_RS07800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYN59_RS07815	COG4771	TonB-dependent receptor
HYN59_RS07835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYN59_RS07845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYN59_RS07850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYN59_RS07910	COG1185	polyribonucleotide nucleotidyltransferase activity
HYN59_RS07915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYN59_RS07985	COG0459	protein refolding
HYN59_RS07990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYN59_RS08020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYN59_RS08035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYN59_RS08035	COG0515	serine threonine protein kinase
HYN59_RS08095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HYN59_RS08150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYN59_RS08175	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYN59_RS08180	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYN59_RS08185	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYN59_RS08210	COG1160	GTP binding
HYN59_RS08215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYN59_RS08230	COG0484	heat shock protein binding
HYN59_RS08240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYN59_RS08250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYN59_RS08255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HYN59_RS08260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HYN59_RS08265	COG0250	Participates in transcription elongation, termination and antitermination
HYN59_RS08285	COG0529	Catalyzes the synthesis of activated sulfate
HYN59_RS08290	COG0175	sulfate reduction
HYN59_RS08300	COG2244	polysaccharide biosynthetic process
HYN59_RS08305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYN59_RS08310	COG1045	serine acetyltransferase
HYN59_RS08320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HYN59_RS08345	COG0438	transferase activity, transferring glycosyl groups
HYN59_RS08360	COG0438	transferase activity, transferring glycosyl groups
HYN59_RS08365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYN59_RS08375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYN59_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS08390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYN59_RS08410	COG4464	protein tyrosine phosphatase activity
HYN59_RS08430	COG3757	hydrolase, family 25
HYN59_RS08450	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HYN59_RS08470	COG0514	ATP-dependent DNA helicase (RecQ)
HYN59_RS08475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HYN59_RS08475	COG0517	IMP dehydrogenase activity
HYN59_RS08480	COG0805	protein transport
HYN59_RS08485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYN59_RS08490	COG1137	ATPase activity
HYN59_RS08505	COG2755	lipolytic protein G-D-S-L family
HYN59_RS08505	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HYN59_RS08530	COG1285	pathogenesis
HYN59_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS08615	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYN59_RS08620	COG0791	NLP P60 protein
HYN59_RS08620	COG1388	LysM domain
HYN59_RS08625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYN59_RS08650	COG1858	cytochrome C peroxidase
HYN59_RS08660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HYN59_RS08670	COG0321	lipoyl(octanoyl) transferase activity
HYN59_RS08675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYN59_RS08685	COG4206	TonB-dependent receptor
HYN59_RS08685	COG1629	transport
HYN59_RS08720	COG2259	Doxx family
HYN59_RS08750	COG1960	acyl-CoA dehydrogenase activity
HYN59_RS08755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HYN59_RS08760	COG4974	Belongs to the 'phage' integrase family
HYN59_RS08785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYN59_RS08805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYN59_RS08810	COG0081	regulation of translation
HYN59_RS08815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYN59_RS08820	COG0222	ribosome binding
HYN59_RS08825	COG0085	RNA polymerase activity
HYN59_RS08830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HYN59_RS08855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYN59_RS08880	COG0681	Belongs to the peptidase S26 family
HYN59_RS08885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYN59_RS08895	COG1475	DNA binding
HYN59_RS08900	COG1192	Involved in chromosome partitioning
HYN59_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS08925	COG4771	TonB-dependent receptor
HYN59_RS08975	COG2354	Protein conserved in bacteria
HYN59_RS08990	COG2217	Heavy metal translocating P-type atpase
HYN59_RS09000	COG0288	reversible hydration of carbon dioxide
HYN59_RS09020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN59_RS09020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN59_RS09025	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN59_RS09065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYN59_RS09085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYN59_RS09100	COG0714	Associated with various cellular activities
HYN59_RS09145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYN59_RS09150	COG1073	alpha beta
HYN59_RS09175	COG0488	(ABC) transporter
HYN59_RS09185	COG4206	TonB-dependent receptor
HYN59_RS09185	COG1629	transport
HYN59_RS09200	COG2326	polyphosphate kinase activity
HYN59_RS09230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HYN59_RS09240	COG1959	2 iron, 2 sulfur cluster binding
HYN59_RS09250	COG2223	nitrite transmembrane transporter activity
HYN59_RS09255	COG2259	Doxx family
HYN59_RS09265	COG0277	FAD linked oxidase domain protein
HYN59_RS09285	COG1136	(ABC) transporter
HYN59_RS09300	COG0653	protein targeting
HYN59_RS09330	COG1607	acyl-coa hydrolase
HYN59_RS09355	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HYN59_RS09395	COG0488	(ABC) transporter
HYN59_RS09400	COG3177	Filamentation induced by cAMP protein fic
HYN59_RS09410	COG0071	Belongs to the small heat shock protein (HSP20) family
HYN59_RS09425	COG1215	transferase activity, transferring glycosyl groups
HYN59_RS09430	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYN59_RS09445	COG1051	belongs to the nudix hydrolase family
HYN59_RS09485	COG0739	heme binding
HYN59_RS09510	COG1132	(ABC) transporter
HYN59_RS09515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYN59_RS09520	COG0463	Glycosyl transferase, family 2
HYN59_RS09530	COG0254	rRNA binding
HYN59_RS09555	COG5002	protein histidine kinase activity
HYN59_RS09565	COG0747	negative chemotaxis
HYN59_RS09570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYN59_RS09585	COG1741	Belongs to the pirin family
HYN59_RS09665	COG2353	YceI-like domain
HYN59_RS09675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYN59_RS09680	COG0811	peptide transport
HYN59_RS09700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HYN59_RS09705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYN59_RS09710	COG0215	cysteine-tRNA ligase activity
HYN59_RS09715	COG0302	gtp cyclohydrolase
HYN59_RS09730	COG4206	TonB-dependent receptor
HYN59_RS09745	COG1595	DNA-templated transcription, initiation
HYN59_RS09785	COG1217	gtp-binding protein TYPA
HYN59_RS09810	COG3275	phosphorelay sensor kinase activity
HYN59_RS09825	COG3279	Response regulator of the LytR AlgR family
HYN59_RS09855	COG0343	queuine tRNA-ribosyltransferase activity
HYN59_RS09870	COG0825	malonyl-CoA metabolic process
HYN59_RS09875	COG0305	Participates in initiation and elongation during chromosome replication
HYN59_RS09885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYN59_RS09885	COG0574	Belongs to the PEP-utilizing enzyme family
HYN59_RS09910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYN59_RS09920	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYN59_RS09930	COG0564	pseudouridine synthase activity
HYN59_RS09940	COG1741	Belongs to the pirin family
HYN59_RS09970	COG2197	response regulator
HYN59_RS09980	COG3022	response to hydroperoxide
HYN59_RS10010	COG0512	Glutamine amidotransferase of anthranilate synthase
HYN59_RS10010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYN59_RS10015	COG1045	serine acetyltransferase
HYN59_RS10030	COG0778	Nitroreductase
HYN59_RS10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN59_RS10050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYN59_RS10055	COG2204	response regulator
HYN59_RS10075	COG3279	Response regulator of the LytR AlgR family
HYN59_RS10080	COG0475	glutathione-regulated potassium exporter activity
HYN59_RS10100	COG1741	Belongs to the pirin family
HYN59_RS10105	COG0400	carboxylic ester hydrolase activity
HYN59_RS10110	COG0346	lactoylglutathione lyase activity
HYN59_RS10145	COG1595	DNA-templated transcription, initiation
HYN59_RS10150	COG0217	transcriptional regulatory protein
HYN59_RS10155	COG0793	Belongs to the peptidase S41A family
HYN59_RS10160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYN59_RS10165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYN59_RS10170	COG0083	homoserine kinase activity
HYN59_RS10175	COG0527	aspartate kinase activity
HYN59_RS10175	COG0460	homoserine dehydrogenase
HYN59_RS10180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYN59_RS10190	COG2986	histidine ammonia-lyase
HYN59_RS10225	COG0189	ligase activity
HYN59_RS10225	COG4067	protein conserved in archaea
HYN59_RS10255	COG0542	response to heat
HYN59_RS10265	COG3063	Type IV pilus biogenesis stability protein PilW
HYN59_RS10285	COG2342	PFAM TM1410 hypothetical-related protein
HYN59_RS10300	COG4251	negative regulation of phosphorylation
HYN59_RS10305	COG4251	negative regulation of phosphorylation
HYN59_RS10310	COG0443	Heat shock 70 kDa protein
HYN59_RS10335	COG4771	TonB-dependent receptor
HYN59_RS10355	COG0791	NLP P60 protein
HYN59_RS10360	COG0183	Belongs to the thiolase family
HYN59_RS10370	COG1764	response to oxidative stress
HYN59_RS10400	COG2207	Transcriptional regulator
HYN59_RS10400	COG1917	Cupin 2, conserved barrel domain protein
HYN59_RS10410	COG1064	alcohol dehydrogenase
HYN59_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS10430	COG1733	regulation of RNA biosynthetic process
HYN59_RS10465	COG2133	pyrroloquinoline quinone binding
HYN59_RS10475	COG0628	permease
HYN59_RS10495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HYN59_RS10505	COG0205	6-phosphofructokinase activity
HYN59_RS10520	COG0251	oxidation-reduction process
HYN59_RS10530	COG1388	LysM domain
HYN59_RS10530	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYN59_RS10535	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYN59_RS10545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HYN59_RS10550	COG0247	lactate metabolic process
HYN59_RS10550	COG2181	nitrate reductase activity
HYN59_RS10560	COG2181	nitrate reductase activity
HYN59_RS10560	COG0247	lactate metabolic process
HYN59_RS10570	COG1472	Belongs to the glycosyl hydrolase 3 family
HYN59_RS10580	COG0438	transferase activity, transferring glycosyl groups
HYN59_RS10610	COG2217	Heavy metal translocating P-type atpase
HYN59_RS10625	COG0513	Belongs to the DEAD box helicase family
HYN59_RS10630	COG0010	Belongs to the arginase family
HYN59_RS10640	COG1228	amidohydrolase
HYN59_RS10645	COG0598	Magnesium transport protein CorA
HYN59_RS10650	COG1247	-acetyltransferase
HYN59_RS10660	COG1960	acyl-CoA dehydrogenase activity
HYN59_RS10670	COG0183	Belongs to the thiolase family
HYN59_RS10680	COG1024	Enoyl-CoA hydratase
HYN59_RS10680	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYN59_RS10690	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HYN59_RS10695	COG1022	Amp-dependent synthetase and ligase
HYN59_RS10700	COG1368	sulfuric ester hydrolase activity
HYN59_RS10745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYN59_RS10745	COG0047	phosphoribosylformylglycinamidine synthase activity
HYN59_RS10760	COG3047	cAMP biosynthetic process
HYN59_RS10785	COG2050	protein possibly involved in aromatic compounds catabolism
HYN59_RS10795	COG0791	NLP P60 protein
HYN59_RS10820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYN59_RS10835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYN59_RS10845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYN59_RS10855	COG2824	Alkylphosphonate utilization operon protein PhnA
HYN59_RS10860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYN59_RS10860	COG0519	Catalyzes the synthesis of GMP from XMP
HYN59_RS10870	COG1388	LysM domain
HYN59_RS10870	COG3942	CHAP domain
HYN59_RS10880	COG3530	Putative quorum-sensing-regulated virulence factor
HYN59_RS10885	COG0504	CTP synthase activity
HYN59_RS10890	COG0706	membrane insertase activity
HYN59_RS10900	COG0482	sulfurtransferase activity
HYN59_RS10910	COG0084	hydrolase, TatD family'
HYN59_RS10915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYN59_RS10950	COG2197	response regulator
HYN59_RS10975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYN59_RS10990	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HYN59_RS10990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYN59_RS11005	COG0783	Belongs to the Dps family
HYN59_RS11015	COG0659	secondary active sulfate transmembrane transporter activity
HYN59_RS11020	COG0288	reversible hydration of carbon dioxide
HYN59_RS11040	COG0784	Response regulator, receiver
HYN59_RS11105	COG1136	(ABC) transporter
HYN59_RS11110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN59_RS11125	COG0737	Belongs to the 5'-nucleotidase family
HYN59_RS11140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYN59_RS11165	COG0497	DNA recombination
HYN59_RS11170	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYN59_RS11190	COG0237	dephospho-CoA kinase activity
HYN59_RS11210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYN59_RS11215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYN59_RS11220	COG2176	DNA-directed DNA polymerase activity
HYN59_RS11225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYN59_RS11235	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYN59_RS11245	COG0673	inositol 2-dehydrogenase activity
HYN59_RS11250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYN59_RS11265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HYN59_RS11295	COG0668	transmembrane transport
HYN59_RS11300	COG0308	aminopeptidase N
HYN59_RS11355	COG2094	Belongs to the DNA glycosylase MPG family
HYN59_RS11365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYN59_RS11370	COG0783	Belongs to the Dps family
HYN59_RS11390	COG3604	Transcriptional regulator
HYN59_RS11400	COG2267	carboxylic ester hydrolase activity
HYN59_RS11410	COG2814	Major facilitator Superfamily
HYN59_RS11415	COG1335	isochorismatase
HYN59_RS11420	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYN59_RS11440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYN59_RS11460	COG2814	Major facilitator Superfamily
HYN59_RS11470	COG0626	cystathionine gamma-synthase activity
HYN59_RS11505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HYN59_RS11540	COG3853	Toxic anion resistance protein (TelA)
HYN59_RS11555	COG2310	stress, protein
HYN59_RS11570	COG4245	von Willebrand factor, type A
HYN59_RS11585	COG0861	Integral membrane protein TerC family
HYN59_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS11610	COG2234	aminopeptidase activity
HYN59_RS11620	COG0693	protein deglycase activity
HYN59_RS11625	COG2323	membrane
HYN59_RS11665	COG1515	deoxyribonuclease V activity
HYN59_RS11745	COG2356	endonuclease I
HYN59_RS11750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYN59_RS11750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYN59_RS11755	COG1917	Cupin 2, conserved barrel domain protein
HYN59_RS11755	COG4977	sequence-specific DNA binding
HYN59_RS11780	COG1595	DNA-templated transcription, initiation
HYN59_RS11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYN59_RS11795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYN59_RS11800	COG0415	Belongs to the DNA photolyase family
HYN59_RS11835	COG0424	maF-like protein
HYN59_RS11860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYN59_RS11860	COG1333	cytochrome c biogenesis protein
HYN59_RS11865	COG0386	Belongs to the glutathione peroxidase family
HYN59_RS11875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HYN59_RS11895	COG3473	Maleate cis-trans isomerase
HYN59_RS11900	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYN59_RS11930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYN59_RS11960	COG0009	L-threonylcarbamoyladenylate synthase
HYN59_RS11985	COG4251	negative regulation of phosphorylation
HYN59_RS11990	COG0784	Response regulator, receiver
HYN59_RS11990	COG2205	protein histidine kinase activity
HYN59_RS12000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYN59_RS12035	COG1674	ftsk spoiiie
HYN59_RS12045	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYN59_RS12075	COG0450	alkyl hydroperoxide reductase
HYN59_RS12080	COG0531	amino acid
HYN59_RS12080	COG0531	amino acid
HYN59_RS12095	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYN59_RS12110	COG0686	Belongs to the AlaDH PNT family
HYN59_RS12115	COG0802	atpase or kinase
HYN59_RS12120	COG0745	RESPONSE REGULATOR receiver
HYN59_RS12180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYN59_RS12185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN59_RS12190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN59_RS12200	COG0366	Alpha amylase catalytic
HYN59_RS12210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYN59_RS12225	COG2270	Major facilitator Superfamily
HYN59_RS12240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYN59_RS12250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYN59_RS12255	COG2211	Major facilitator Superfamily
HYN59_RS12305	COG1078	dGTPase activity
HYN59_RS12310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN59_RS12315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYN59_RS12315	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HYN59_RS12320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYN59_RS12325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYN59_RS12345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYN59_RS12350	COG3609	addiction module antidote protein, CC2985 family
HYN59_RS12365	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYN59_RS12380	COG3685	Protein conserved in bacteria
HYN59_RS12435	COG0488	(ABC) transporter
HYN59_RS12450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYN59_RS12465	COG3011	Protein conserved in bacteria
HYN59_RS12475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYN59_RS12490	COG0813	purine-nucleoside phosphorylase activity
HYN59_RS12495	COG0023	Translation Initiation Factor
HYN59_RS12530	COG1090	epimerase
HYN59_RS12540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYN59_RS12550	COG1595	DNA-templated transcription, initiation
HYN59_RS12555	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HYN59_RS12575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYN59_RS12595	COG0156	8-amino-7-oxononanoate synthase activity
HYN59_RS12660	COG0708	Exodeoxyribonuclease III
HYN59_RS12685	COG0484	heat shock protein binding
HYN59_RS12720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYN59_RS12725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYN59_RS12750	COG1595	DNA-templated transcription, initiation
HYN59_RS12755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYN59_RS12760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYN59_RS12785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYN59_RS12785	COG0321	lipoyl(octanoyl) transferase activity
HYN59_RS12815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYN59_RS12825	COG2706	6-phosphogluconolactonase activity
HYN59_RS12830	COG0513	Belongs to the DEAD box helicase family
HYN59_RS12870	COG1012	belongs to the aldehyde dehydrogenase family
HYN59_RS12875	COG0022	dehydrogenase e1 component
HYN59_RS12885	COG1611	Belongs to the LOG family
HYN59_RS12890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYN59_RS12905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYN59_RS12915	COG4628	conserved protein (DUF2132)
HYN59_RS12925	COG1122	ATPase activity
HYN59_RS12955	COG0542	response to heat
HYN59_RS12960	COG3118	belongs to the thioredoxin family
HYN59_RS12975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYN59_RS12980	COG1595	DNA-templated transcription, initiation
HYN59_RS13015	COG0116	Belongs to the methyltransferase superfamily
HYN59_RS13035	COG0823	Involved in the tonB-independent uptake of proteins
HYN59_RS13035	COG1506	peptidase
HYN59_RS13050	COG0626	cystathionine gamma-synthase activity
HYN59_RS13055	COG1522	sequence-specific DNA binding
HYN59_RS13070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYN59_RS13080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HYN59_RS13085	COG0037	tRNA processing
HYN59_RS13095	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYN59_RS13115	COG0606	chelatase, subunit chli
HYN59_RS13125	COG2321	neutral zinc metallopeptidase
HYN59_RS13140	COG0564	pseudouridine synthase activity
HYN59_RS13145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HYN59_RS13155	COG1760	l-serine dehydratase
HYN59_RS13170	COG2989	Protein conserved in bacteria
HYN59_RS13175	COG2996	Protein conserved in bacteria
HYN59_RS13180	COG3384	dioxygenase
HYN59_RS13205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HYN59_RS13225	COG1575	Belongs to the MenA family. Type 1 subfamily
HYN59_RS13230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYN59_RS13235	COG4948	Mandelate Racemase Muconate Lactonizing
HYN59_RS13275	COG4251	negative regulation of phosphorylation
HYN59_RS13300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYN59_RS13310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYN59_RS13320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYN59_RS13335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYN59_RS13340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYN59_RS13355	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HYN59_RS13420	COG0012	GTP binding
HYN59_RS13440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYN59_RS13450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HYN59_RS13455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYN59_RS13465	COG1187	pseudouridine synthase activity
HYN59_RS13490	COG1252	NADH dehydrogenase
HYN59_RS13495	COG1295	ribonuclease BN
HYN59_RS13500	COG2814	Major facilitator Superfamily
HYN59_RS13505	COG0668	transmembrane transport
HYN59_RS13510	COG1607	acyl-coa hydrolase
HYN59_RS13515	COG1051	belongs to the nudix hydrolase family
HYN59_RS13520	COG0022	dehydrogenase e1 component
HYN59_RS13540	COG0745	RESPONSE REGULATOR receiver
HYN59_RS13595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYN59_RS13625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HYN59_RS13630	COG1522	sequence-specific DNA binding
HYN59_RS13655	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HYN59_RS13660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HYN59_RS13690	COG4499	WXG100 protein secretion system (Wss), protein YukC
HYN59_RS13690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYN59_RS13710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYN59_RS13730	COG0248	Ppx GppA phosphatase
HYN59_RS13735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HYN59_RS13745	COG0259	pyridoxamine-phosphate oxidase activity
HYN59_RS13750	COG1234	tRNA 3'-trailer cleavage
HYN59_RS13760	COG0540	Belongs to the ATCase OTCase family
HYN59_RS13770	COG0488	(ABC) transporter
HYN59_RS13780	COG0517	IMP dehydrogenase activity
HYN59_RS13780	COG0516	GMP reductase activity
HYN59_RS13795	COG0659	secondary active sulfate transmembrane transporter activity
HYN59_RS13805	COG0167	dihydroorotate dehydrogenase activity
HYN59_RS13820	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYN59_RS13830	COG1862	Preprotein translocase
HYN59_RS13840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HYN59_RS13850	COG1132	(ABC) transporter
HYN59_RS13865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYN59_RS13885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYN59_RS13895	COG2226	methyltransferase
HYN59_RS13910	COG0336	Belongs to the RNA methyltransferase TrmD family
HYN59_RS13915	COG0335	large ribosomal subunit rRNA binding
HYN59_RS13970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYN59_RS13980	COG0573	inorganic phosphate transmembrane transporter activity
HYN59_RS13995	COG1959	2 iron, 2 sulfur cluster binding
HYN59_RS14005	COG0556	nucleotide-excision repair
HYN59_RS14035	COG2819	hydrolase of the alpha beta superfamily
HYN59_RS14050	COG2819	hydrolase of the alpha beta superfamily
HYN59_RS14070	COG0045	succinate-CoA ligase (ADP-forming) activity
HYN59_RS14080	COG0019	diaminopimelate decarboxylase activity
HYN59_RS14130	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HYN59_RS14150	COG0697	spore germination
HYN59_RS14165	COG1295	ribonuclease BN
HYN59_RS14175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYN59_RS14180	COG3279	Response regulator of the LytR AlgR family
HYN59_RS14185	COG0360	Binds together with S18 to 16S ribosomal RNA
HYN59_RS14190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYN59_RS14195	COG0359	binds to the 23S rRNA
HYN59_RS14205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HYN59_RS14225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HYN59_RS14235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYN59_RS14250	COG0601	transmembrane transport
HYN59_RS14255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN59_RS14260	COG0149	triose-phosphate isomerase activity
HYN59_RS14275	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HYN59_RS14280	COG3279	Response regulator of the LytR AlgR family
HYN59_RS14285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYN59_RS14300	COG0038	chloride channel
HYN59_RS14310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYN59_RS14315	COG0300	oxidoreductase activity
HYN59_RS14335	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HYN59_RS14345	COG3781	membrane
HYN59_RS14395	COG0101	tRNA pseudouridine synthase activity
HYN59_RS14410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYN59_RS14445	COG1104	cysteine desulfurase activity
HYN59_RS14480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYN59_RS14485	COG2378	regulation of single-species biofilm formation
HYN59_RS14500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYN59_RS14535	COG1363	Peptidase, m42
HYN59_RS14545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HYN59_RS14555	COG1702	phosphate starvation-inducible protein PhoH
HYN59_RS14580	COG0592	DNA-directed DNA polymerase activity
HYN59_RS14585	COG2267	carboxylic ester hydrolase activity
HYN59_RS14595	COG0589	response to stress
HYN59_RS14600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYN59_RS14735	COG0798	PFAM Bile acid sodium symporter
HYN59_RS14775	COG1629	transport
HYN59_RS14795	COG2815	serine threonine protein kinase
HYN59_RS14795	COG0515	serine threonine protein kinase
HYN59_RS14905	COG0551	DNA topoisomerase type I activity
HYN59_RS14905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYN59_RS14925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYN59_RS14930	COG0587	DNA-directed DNA polymerase activity
HYN59_RS14935	COG1199	ATP-dependent helicase activity
HYN59_RS14935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYN59_RS14975	COG0210	DNA helicase
HYN59_RS15055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYN59_RS15070	COG0702	epimerase
HYN59_RS15075	COG4771	TonB-dependent receptor
HYN59_RS15080	COG1621	beta-fructofuranosidase activity
HYN59_RS15085	COG2814	Major facilitator Superfamily
HYN59_RS15090	COG3292	Two component regulator propeller
HYN59_RS15090	COG0745	RESPONSE REGULATOR receiver
HYN59_RS15090	COG2205	protein histidine kinase activity
HYN59_RS15105	COG3275	phosphorelay sensor kinase activity
HYN59_RS15115	COG1136	(ABC) transporter
HYN59_RS15120	COG0577	efflux transmembrane transporter activity
HYN59_RS15120	COG1136	(ABC) transporter
HYN59_RS15200	COG3291	Pkd domain containing protein
HYN59_RS15240	COG1611	Belongs to the LOG family
HYN59_RS15265	COG2823	Periplasmic or secreted lipoprotein
HYN59_RS15270	COG2823	Periplasmic or secreted lipoprotein
HYN59_RS15280	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HYN59_RS15285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYN59_RS15295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYN59_RS15315	COG0484	heat shock protein binding
HYN59_RS15340	COG2194	sulfuric ester hydrolase activity
HYN59_RS15395	COG0574	Belongs to the PEP-utilizing enzyme family
HYN59_RS15395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYN59_RS15400	COG4191	Histidine kinase
HYN59_RS15410	COG0589	response to stress
HYN59_RS15420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYN59_RS15425	COG1733	regulation of RNA biosynthetic process
HYN59_RS15475	COG0427	acetyl-CoA hydrolase
HYN59_RS15490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN59_RS15525	COG3292	Two component regulator propeller
HYN59_RS15525	COG0745	RESPONSE REGULATOR receiver
HYN59_RS15525	COG2205	protein histidine kinase activity
HYN59_RS15530	COG4771	TonB-dependent receptor
HYN59_RS15540	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HYN59_RS15555	COG0366	Alpha amylase catalytic
HYN59_RS15565	COG2226	methyltransferase
HYN59_RS15595	COG3537	Alpha-1,2-mannosidase
HYN59_RS15610	COG4251	negative regulation of phosphorylation
HYN59_RS15635	COG1272	protein, Hemolysin III
HYN59_RS15640	COG4251	negative regulation of phosphorylation
HYN59_RS15650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYN59_RS15650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYN59_RS15685	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HYN59_RS15740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYN59_RS15750	COG1858	cytochrome C peroxidase
HYN59_RS15780	COG1917	Cupin 2, conserved barrel domain protein
HYN59_RS15780	COG2207	Transcriptional regulator
HYN59_RS15790	COG1012	belongs to the aldehyde dehydrogenase family
HYN59_RS15795	COG0306	phosphate transporter
HYN59_RS15805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYN59_RS15810	COG2226	methyltransferase
HYN59_RS15835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYN59_RS15850	COG1266	CAAX protease self-immunity
HYN59_RS15855	COG1393	Belongs to the ArsC family
HYN59_RS15870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYN59_RS15875	COG0730	response to heat
HYN59_RS15880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYN59_RS15880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYN59_RS15885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYN59_RS15895	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HYN59_RS15915	COG0702	epimerase
HYN59_RS15930	COG3046	protein related to deoxyribodipyrimidine photolyase
HYN59_RS15935	COG4251	negative regulation of phosphorylation
HYN59_RS15945	COG0009	L-threonylcarbamoyladenylate synthase
HYN59_RS15960	COG0473	3-isopropylmalate dehydrogenase activity
HYN59_RS15965	COG0583	DNA-binding transcription factor activity
HYN59_RS15995	COG0738	Major facilitator superfamily
HYN59_RS16005	COG1082	Xylose isomerase domain protein TIM barrel
HYN59_RS16040	COG0702	epimerase
HYN59_RS16045	COG4771	TonB-dependent receptor
HYN59_RS16080	COG2207	Transcriptional regulator
HYN59_RS16080	COG1609	Transcriptional regulator
HYN59_RS16160	COG5002	protein histidine kinase activity
HYN59_RS16165	COG0745	RESPONSE REGULATOR receiver
HYN59_RS16170	COG0640	Transcriptional regulator
HYN59_RS16185	COG0798	PFAM Bile acid sodium symporter
HYN59_RS16190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYN59_RS16195	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HYN59_RS16200	COG3387	PFAM Glycoside hydrolase 15-related
HYN59_RS16210	COG0668	transmembrane transport
HYN59_RS16215	COG4251	negative regulation of phosphorylation
HYN59_RS16220	COG0784	Response regulator, receiver
HYN59_RS16225	COG3279	Response regulator of the LytR AlgR family
HYN59_RS16250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYN59_RS16280	COG0562	UDP-galactopyranose mutase
HYN59_RS16305	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS16310	COG3685	Protein conserved in bacteria
HYN59_RS16345	COG0189	ligase activity
HYN59_RS16345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYN59_RS16365	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS16375	COG3279	Response regulator of the LytR AlgR family
HYN59_RS16400	COG1063	alcohol dehydrogenase
HYN59_RS16420	COG1793	dna ligase
HYN59_RS16420	COG3285	dna ligase
HYN59_RS16455	COG3292	Two component regulator propeller
HYN59_RS16455	COG2205	protein histidine kinase activity
HYN59_RS16455	COG0745	RESPONSE REGULATOR receiver
HYN59_RS16465	COG1793	dna ligase
HYN59_RS16470	COG1201	RNA secondary structure unwinding
HYN59_RS16480	COG2274	protein secretion by the type I secretion system
HYN59_RS16505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYN59_RS16510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN59_RS16515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN59_RS16515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYN59_RS16535	COG0714	Associated with various cellular activities
HYN59_RS16565	COG0705	Rhomboid family
HYN59_RS16575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYN59_RS16585	COG2264	protein methyltransferase activity
HYN59_RS16610	COG4771	TonB-dependent receptor
HYN59_RS16615	COG0702	epimerase
HYN59_RS16695	COG1703	isobutyryl-CoA mutase activity
HYN59_RS16695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN59_RS16695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYN59_RS16735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYN59_RS16740	COG0284	orotidine-5'-phosphate decarboxylase activity
HYN59_RS16750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYN59_RS16760	COG0492	ferredoxin-NADP+ reductase activity
HYN59_RS16795	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYN59_RS16800	COG2361	Protein of unknown function DUF86
HYN59_RS16845	COG0494	nUDIX hydrolase
HYN59_RS16895	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HYN59_RS16895	COG2755	lipolytic protein G-D-S-L family
HYN59_RS16920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYN59_RS16925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HYN59_RS16930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HYN59_RS16935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYN59_RS16940	COG1446	asparaginase
HYN59_RS16960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYN59_RS16990	COG0799	negative regulation of ribosome biogenesis
HYN59_RS16995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYN59_RS17005	COG4589	Belongs to the CDS family
HYN59_RS17010	COG0688	phosphatidylethanolamine metabolic process
HYN59_RS17020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYN59_RS17030	COG0525	valine-tRNA ligase activity
HYN59_RS17040	COG0436	Aminotransferase
HYN59_RS17060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYN59_RS17065	COG1120	ATPase activity
HYN59_RS17100	COG0187	DNA topoisomerase II activity
HYN59_RS17110	COG0367	asparagine synthase
HYN59_RS17130	COG2884	Cell division ATP-binding protein ftsE
HYN59_RS17155	COG1216	Glycosyl transferase, family 2
HYN59_RS17155	COG1442	glycosyl transferase family 8
HYN59_RS17165	COG0438	transferase activity, transferring glycosyl groups
HYN59_RS17180	COG0110	maltose O-acetyltransferase activity
HYN59_RS17215	COG0038	chloride channel
HYN59_RS17255	COG1131	(ABC) transporter
HYN59_RS17325	COG0714	Associated with various cellular activities
HYN59_RS17345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYN59_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
HYN59_RS17370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYN59_RS17385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYN59_RS17395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYN59_RS17410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HYN59_RS17430	COG3956	TIGRFAM MazG family protein
HYN59_RS17440	COG0242	peptide deformylase activity
HYN59_RS17445	COG1289	transmembrane transporter activity
HYN59_RS17455	COG0579	oxidoreductase
HYN59_RS17460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYN59_RS17470	COG2226	methyltransferase
HYN59_RS17480	COG2171	N-acyltransferase activity
HYN59_RS17485	COG0463	Glycosyl transferase, family 2
HYN59_RS17520	COG0562	UDP-galactopyranose mutase
HYN59_RS17540	COG0617	tRNA 3'-terminal CCA addition
HYN59_RS17545	COG1612	heme a metabolic process
HYN59_RS17555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYN59_RS17560	COG3958	Transketolase
HYN59_RS17570	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYN59_RS17575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HYN59_RS17580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYN59_RS17615	COG0784	Response regulator, receiver
HYN59_RS17615	COG2205	protein histidine kinase activity
HYN59_RS17615	COG5002	protein histidine kinase activity
HYN59_RS17620	COG1396	sequence-specific DNA binding
HYN59_RS17620	COG3800	Transcriptional regulator
HYN59_RS17625	COG1960	acyl-CoA dehydrogenase activity
HYN59_RS17645	COG4585	Histidine kinase
HYN59_RS17710	COG0628	permease
HYN59_RS17720	COG0268	Binds directly to 16S ribosomal RNA
HYN59_RS17735	COG0442	prolyl-tRNA aminoacylation
HYN59_RS17750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYN59_RS17770	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HYN59_RS17785	COG0105	UTP biosynthetic process
HYN59_RS17810	COG0552	protein localization to endoplasmic reticulum
HYN59_RS17820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYN59_RS17825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYN59_RS17830	COG1058	Belongs to the CinA family
HYN59_RS17830	COG1546	Belongs to the CinA family
HYN59_RS17840	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYN59_RS17845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYN59_RS17850	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HYN59_RS17885	COG0124	histidyl-tRNA synthetase
HYN59_RS17890	COG0577	efflux transmembrane transporter activity
HYN59_RS17895	COG2890	protein-(glutamine-N5) methyltransferase activity
HYN59_RS17900	COG0456	acetyltransferase
HYN59_RS17905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYN59_RS17905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYN59_RS17920	COG1739	Uncharacterized protein family UPF0029
HYN59_RS17925	COG0824	Thioesterase