locus-tag	class	description
HQN62_RS00015	COG2226	methyltransferase
HQN62_RS00020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HQN62_RS00035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HQN62_RS00045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HQN62_RS00050	COG2086	electron transfer activity
HQN62_RS00055	COG0022	dehydrogenase e1 component
HQN62_RS00055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQN62_RS00065	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HQN62_RS00070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HQN62_RS00075	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HQN62_RS00080	COG1428	Deoxynucleoside kinase
HQN62_RS00085	COG0793	Belongs to the peptidase S41A family
HQN62_RS00090	COG0793	Belongs to the peptidase S41A family
HQN62_RS00095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HQN62_RS00105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQN62_RS00110	COG2333	competence protein COMEC
HQN62_RS00110	COG0658	competence protein
HQN62_RS00115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQN62_RS00120	COG3104	oligopeptide transport
HQN62_RS00125	COG3104	oligopeptide transport
HQN62_RS00130	COG1506	peptidase
HQN62_RS00130	COG0823	Involved in the tonB-independent uptake of proteins
HQN62_RS00145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQN62_RS00150	COG1253	flavin adenine dinucleotide binding
HQN62_RS00170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HQN62_RS00215	COG4251	negative regulation of phosphorylation
HQN62_RS00220	COG2198	Histidine kinase
HQN62_RS00220	COG0643	Histidine kinase
HQN62_RS00220	COG0784	Response regulator, receiver
HQN62_RS00230	COG1472	Belongs to the glycosyl hydrolase 3 family
HQN62_RS00240	COG1187	pseudouridine synthase activity
HQN62_RS00265	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HQN62_RS00275	COG2081	HI0933 family
HQN62_RS00280	COG0584	glycerophosphoryl diester phosphodiesterase
HQN62_RS00285	COG0366	Alpha amylase catalytic
HQN62_RS00290	COG1501	Belongs to the glycosyl hydrolase 31 family
HQN62_RS00295	COG0366	Alpha amylase catalytic
HQN62_RS00300	COG1554	hydrolase, family 65, central catalytic
HQN62_RS00305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQN62_RS00310	COG2211	Major facilitator Superfamily
HQN62_RS00320	COG4206	TonB-dependent receptor
HQN62_RS00320	COG1629	transport
HQN62_RS00325	COG0702	epimerase
HQN62_RS00335	COG1523	belongs to the glycosyl hydrolase 13 family
HQN62_RS00405	COG2363	Small membrane protein
HQN62_RS00410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQN62_RS00425	COG2315	Protein conserved in bacteria
HQN62_RS00445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQN62_RS00450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HQN62_RS00515	COG3118	belongs to the thioredoxin family
HQN62_RS00530	COG3002	Belongs to the UPF0753 family
HQN62_RS00535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HQN62_RS00545	COG0583	DNA-binding transcription factor activity
HQN62_RS00550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HQN62_RS00555	COG0066	3-isopropylmalate dehydratase activity
HQN62_RS00560	COG2329	Antibiotic biosynthesis monooxygenase
HQN62_RS00565	COG4106	trans-aconitate 2-methyltransferase activity
HQN62_RS00570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HQN62_RS00580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HQN62_RS00600	COG0228	four-way junction DNA binding
HQN62_RS00605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HQN62_RS00610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HQN62_RS00625	COG1960	acyl-CoA dehydrogenase activity
HQN62_RS00655	COG0489	protein tyrosine kinase activity
HQN62_RS00670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HQN62_RS00675	COG2989	Protein conserved in bacteria
HQN62_RS00695	COG2989	Protein conserved in bacteria
HQN62_RS00715	COG4804	nuclease activity
HQN62_RS00715	COG4804	nuclease activity
HQN62_RS00720	COG3610	response to peptide
HQN62_RS00730	COG1505	serine-type exopeptidase activity
HQN62_RS00760	COG1040	competence protein
HQN62_RS00765	COG0423	glycine-tRNA ligase activity
HQN62_RS00790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HQN62_RS00815	COG0481	GTPase activity
HQN62_RS00830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HQN62_RS00835	COG0346	lactoylglutathione lyase activity
HQN62_RS00935	COG5290	Psort location Cytoplasmic, score
HQN62_RS00945	COG4974	Belongs to the 'phage' integrase family
HQN62_RS00960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HQN62_RS00970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HQN62_RS00975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQN62_RS00985	COG0439	Biotin carboxylase
HQN62_RS01000	COG0596	Alpha beta hydrolase
HQN62_RS01010	COG1506	peptidase
HQN62_RS01010	COG0823	Involved in the tonB-independent uptake of proteins
HQN62_RS01030	COG4771	TonB-dependent receptor
HQN62_RS01035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQN62_RS01040	COG1970	mechanosensitive ion channel activity
HQN62_RS01045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQN62_RS01060	COG1435	thymidine kinase activity
HQN62_RS01070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HQN62_RS01080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HQN62_RS01080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HQN62_RS01100	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQN62_RS01105	COG0720	synthase
HQN62_RS01115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQN62_RS01120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HQN62_RS01125	COG1053	succinate dehydrogenase
HQN62_RS01135	COG3425	synthase
HQN62_RS01145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HQN62_RS01150	COG2224	Isocitrate lyase
HQN62_RS01155	COG0006	proline dipeptidase activity
HQN62_RS01160	COG2267	carboxylic ester hydrolase activity
HQN62_RS01210	COG0328	RNA-DNA hybrid ribonuclease activity
HQN62_RS01215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HQN62_RS01220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQN62_RS01225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQN62_RS01230	COG0571	ribonuclease III activity
HQN62_RS01240	COG0469	pyruvate kinase activity
HQN62_RS01250	COG1082	Xylose isomerase domain protein TIM barrel
HQN62_RS01270	COG0673	inositol 2-dehydrogenase activity
HQN62_RS01300	COG2308	Evidence 4 Homologs of previously reported genes of
HQN62_RS01315	COG1305	Transglutaminase-like
HQN62_RS01325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQN62_RS01330	COG2954	triphosphatase activity
HQN62_RS01335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HQN62_RS01345	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HQN62_RS01355	COG0166	Belongs to the GPI family
HQN62_RS01365	COG3483	tryptophan 2,3-dioxygenase activity
HQN62_RS01375	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HQN62_RS01380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HQN62_RS01385	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQN62_RS01390	COG0322	excinuclease ABC activity
HQN62_RS01405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HQN62_RS01415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HQN62_RS01525	COG1381	Involved in DNA repair and RecF pathway recombination
HQN62_RS01530	COG3292	Two component regulator propeller
HQN62_RS01530	COG2205	protein histidine kinase activity
HQN62_RS01530	COG0745	RESPONSE REGULATOR receiver
HQN62_RS01540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HQN62_RS01550	COG0626	cystathionine gamma-synthase activity
HQN62_RS01565	COG0697	spore germination
HQN62_RS01580	COG0194	GDP metabolic process
HQN62_RS01585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HQN62_RS01600	COG1979	alcohol dehydrogenase
HQN62_RS01605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HQN62_RS01615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HQN62_RS01650	COG2304	oxidoreductase activity
HQN62_RS01670	COG0714	Associated with various cellular activities
HQN62_RS01675	COG4989	oxidoreductase activity
HQN62_RS01695	COG1012	belongs to the aldehyde dehydrogenase family
HQN62_RS01710	COG1619	proteins homologs of microcin C7 resistance protein MccF
HQN62_RS01715	COG0792	nuclease activity
HQN62_RS01725	COG1620	l-lactate permease
HQN62_RS01740	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS01755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HQN62_RS01765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQN62_RS01790	COG2311	Membrane
HQN62_RS01825	COG2252	PERMEase
HQN62_RS01830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQN62_RS01835	COG0316	Belongs to the HesB IscA family
HQN62_RS01840	COG0719	Fe-S assembly protein
HQN62_RS01845	COG0655	NAD(P)H dehydrogenase (quinone) activity
HQN62_RS01850	COG0396	ATPase activity
HQN62_RS01855	COG0719	Fe-S assembly protein
HQN62_RS01865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HQN62_RS01875	COG2166	iron-sulfur cluster assembly
HQN62_RS01885	COG2151	metal-sulfur cluster biosynthetic enzyme
HQN62_RS01900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HQN62_RS01930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQN62_RS01940	COG0756	dUTP diphosphatase activity
HQN62_RS01955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HQN62_RS01960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HQN62_RS01965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQN62_RS01970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HQN62_RS01975	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQN62_RS01980	COG0356	it plays a direct role in the translocation of protons across the membrane
HQN62_RS01995	COG0457	Tetratricopeptide repeat
HQN62_RS02000	COG4152	abc transporter atp-binding protein
HQN62_RS02010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQN62_RS02020	COG0859	PFAM glycosyl transferase family 9
HQN62_RS02030	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HQN62_RS02045	COG0151	Belongs to the GarS family
HQN62_RS02070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQN62_RS02075	COG0438	transferase activity, transferring glycosyl groups
HQN62_RS02075	COG0297	glycogen (starch) synthase activity
HQN62_RS02115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HQN62_RS02130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQN62_RS02135	COG1116	anion transmembrane transporter activity
HQN62_RS02140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HQN62_RS02145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HQN62_RS02175	COG0698	ribose 5-phosphate isomerase
HQN62_RS02185	COG0557	exoribonuclease II activity
HQN62_RS02210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQN62_RS02230	COG0330	HflC and HflK could
HQN62_RS02240	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HQN62_RS02240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQN62_RS02250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HQN62_RS02255	COG0445	tRNA wobble uridine modification
HQN62_RS02275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HQN62_RS02310	COG1309	transcriptional regulator
HQN62_RS02325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQN62_RS02325	COG0758	DNA mediated transformation
HQN62_RS02335	COG0247	lactate metabolic process
HQN62_RS02340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQN62_RS02350	COG1522	sequence-specific DNA binding
HQN62_RS02370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQN62_RS02380	COG1024	Enoyl-CoA hydratase
HQN62_RS02400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HQN62_RS02410	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HQN62_RS02430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HQN62_RS02450	COG0408	coproporphyrinogen oxidase activity
HQN62_RS02455	COG0113	porphobilinogen synthase activity
HQN62_RS02460	COG4654	Cytochrome c, class I
HQN62_RS02475	COG0700	Nucleoside recognition
HQN62_RS02525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HQN62_RS02530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQN62_RS02540	COG1774	PSP1 C-terminal conserved region
HQN62_RS02545	COG0604	alcohol dehydrogenase
HQN62_RS02555	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HQN62_RS02570	COG0826	peptidase U32
HQN62_RS02585	COG2326	polyphosphate kinase activity
HQN62_RS02615	COG1914	H( )-stimulated, divalent metal cation uptake system
HQN62_RS02650	COG1999	signal sequence binding
HQN62_RS02655	COG0697	spore germination
HQN62_RS02660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQN62_RS02680	COG3153	acetyltransferase
HQN62_RS02680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQN62_RS02690	COG0629	single-stranded DNA binding
HQN62_RS02700	COG1528	Iron-storage protein
HQN62_RS02705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HQN62_RS02720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HQN62_RS02725	COG2239	Acts as a magnesium transporter
HQN62_RS02735	COG1607	acyl-coa hydrolase
HQN62_RS02745	COG0470	DNA polymerase III
HQN62_RS02780	COG0126	phosphoglycerate kinase activity
HQN62_RS02785	COG1388	LysM domain
HQN62_RS02785	COG1705	Flagellar rod assembly protein muramidase FlgJ
HQN62_RS02800	COG0793	Belongs to the peptidase S41A family
HQN62_RS02810	COG0594	ribonuclease P activity
HQN62_RS02825	COG1418	mRNA catabolic process
HQN62_RS02835	COG1611	Belongs to the LOG family
HQN62_RS02870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQN62_RS02870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQN62_RS02890	COG0384	phenazine biosynthesis protein PhzF
HQN62_RS02945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQN62_RS02950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQN62_RS02975	COG0501	Belongs to the peptidase M48B family
HQN62_RS02985	COG0708	Exodeoxyribonuclease III
HQN62_RS02990	COG1360	Flagellar Motor Protein
HQN62_RS02995	COG0667	Aldo Keto reductase
HQN62_RS03010	COG2972	Histidine kinase
HQN62_RS03015	COG3279	Response regulator of the LytR AlgR family
HQN62_RS03020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQN62_RS03025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HQN62_RS03035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HQN62_RS03040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HQN62_RS03045	COG0297	glycogen (starch) synthase activity
HQN62_RS03055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HQN62_RS03070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HQN62_RS03095	COG0156	8-amino-7-oxononanoate synthase activity
HQN62_RS03100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HQN62_RS03150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQN62_RS03160	COG0196	riboflavin kinase activity
HQN62_RS03170	COG0193	aminoacyl-tRNA hydrolase activity
HQN62_RS03175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HQN62_RS03180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HQN62_RS03220	COG1082	Xylose isomerase domain protein TIM barrel
HQN62_RS03235	COG2160	L-arabinose isomerase activity
HQN62_RS03260	COG3507	Belongs to the glycosyl hydrolase 43 family
HQN62_RS03270	COG3507	Belongs to the glycosyl hydrolase 43 family
HQN62_RS03280	COG0702	epimerase
HQN62_RS03285	COG4771	TonB-dependent receptor
HQN62_RS03295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQN62_RS03310	COG2017	converts alpha-aldose to the beta-anomer
HQN62_RS03315	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HQN62_RS03325	COG3250	beta-galactosidase activity
HQN62_RS03330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HQN62_RS03335	COG1085	galactose-1-phosphate uridylyltransferase
HQN62_RS03340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQN62_RS03370	COG2115	Belongs to the xylose isomerase family
HQN62_RS03375	COG4771	TonB-dependent receptor
HQN62_RS03390	COG3250	beta-galactosidase activity
HQN62_RS03395	COG1501	Belongs to the glycosyl hydrolase 31 family
HQN62_RS03400	COG1082	Xylose isomerase domain protein TIM barrel
HQN62_RS03410	COG1472	Belongs to the glycosyl hydrolase 3 family
HQN62_RS03415	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HQN62_RS03430	COG0673	inositol 2-dehydrogenase activity
HQN62_RS03435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HQN62_RS03450	COG1007	ATP synthesis coupled electron transport
HQN62_RS03455	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQN62_RS03460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HQN62_RS03465	COG0713	ATP synthesis coupled electron transport
HQN62_RS03475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQN62_RS03480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HQN62_RS03485	COG1034	ATP synthesis coupled electron transport
HQN62_RS03495	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HQN62_RS03500	COG0649	NAD binding
HQN62_RS03505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQN62_RS03510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQN62_RS03515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQN62_RS03520	COG1278	Cold shock
HQN62_RS03525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HQN62_RS03530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQN62_RS03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQN62_RS03625	COG1538	Outer membrane efflux protein
HQN62_RS03630	COG1309	transcriptional regulator
HQN62_RS03655	COG0567	Dehydrogenase, E1 component
HQN62_RS03700	COG0084	hydrolase, TatD family'
HQN62_RS03710	COG0252	asparaginase activity
HQN62_RS03860	COG1070	Carbohydrate kinase
HQN62_RS03865	COG2610	gluconate transmembrane transporter activity
HQN62_RS03870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HQN62_RS03885	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HQN62_RS03890	COG0017	Asparaginyl-tRNA synthetase
HQN62_RS03895	COG0071	Belongs to the small heat shock protein (HSP20) family
HQN62_RS03910	COG0475	glutathione-regulated potassium exporter activity
HQN62_RS03920	COG2076	Multidrug Resistance protein
HQN62_RS03930	COG3279	Response regulator of the LytR AlgR family
HQN62_RS03935	COG0475	glutathione-regulated potassium exporter activity
HQN62_RS03940	COG0784	Response regulator, receiver
HQN62_RS03945	COG4251	negative regulation of phosphorylation
HQN62_RS03955	COG0233	cytoplasmic translational termination
HQN62_RS03960	COG0528	UMP kinase activity
HQN62_RS03975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HQN62_RS03980	COG1968	undecaprenyl-diphosphatase activity
HQN62_RS03990	COG2177	Part of the ABC transporter FtsEX involved in
HQN62_RS04020	COG0495	leucyl-tRNA aminoacylation
HQN62_RS04045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQN62_RS04060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQN62_RS04090	COG4771	TonB-dependent receptor
HQN62_RS04095	COG0745	RESPONSE REGULATOR receiver
HQN62_RS04100	COG5002	protein histidine kinase activity
HQN62_RS04120	COG0581	inorganic phosphate transmembrane transporter activity
HQN62_RS04125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HQN62_RS04155	COG0527	aspartate kinase activity
HQN62_RS04165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HQN62_RS04185	COG0793	Belongs to the peptidase S41A family
HQN62_RS04200	COG2095	MarC family integral membrane protein
HQN62_RS04220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQN62_RS04220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HQN62_RS04225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HQN62_RS04235	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HQN62_RS04245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HQN62_RS04265	COG4953	penicillin-binding protein 1C
HQN62_RS04285	COG4535	Mg2 and Co2 transporter CorC
HQN62_RS04290	COG0629	single-stranded DNA binding
HQN62_RS04315	COG1530	ribonuclease E activity
HQN62_RS04320	COG0612	Peptidase, M16
HQN62_RS04325	COG0612	Peptidase, M16
HQN62_RS04330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HQN62_RS04335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HQN62_RS04350	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQN62_RS04370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HQN62_RS04380	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HQN62_RS04410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQN62_RS04425	COG5002	protein histidine kinase activity
HQN62_RS04430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HQN62_RS04440	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HQN62_RS04445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQN62_RS04450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQN62_RS04455	COG2022	thiamine diphosphate biosynthetic process
HQN62_RS04460	COG0352	thiamine-phosphate diphosphorylase activity
HQN62_RS04465	COG0351	phosphomethylpyrimidine kinase
HQN62_RS04485	COG0519	Catalyzes the synthesis of GMP from XMP
HQN62_RS04495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQN62_RS04495	COG0248	Ppx GppA phosphatase
HQN62_RS04500	COG2211	Major facilitator Superfamily
HQN62_RS04505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HQN62_RS04510	COG0052	Belongs to the universal ribosomal protein uS2 family
HQN62_RS04515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HQN62_RS04525	COG1609	Transcriptional regulator
HQN62_RS04535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQN62_RS04535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQN62_RS04545	COG0745	RESPONSE REGULATOR receiver
HQN62_RS04570	COG0726	polysaccharide deacetylase
HQN62_RS04590	COG0779	Required for maturation of 30S ribosomal subunits
HQN62_RS04595	COG2251	uridine kinase activity
HQN62_RS04595	COG0195	Participates in both transcription termination and antitermination
HQN62_RS04600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HQN62_RS04605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQN62_RS04620	COG0437	4 iron, 4 sulfur cluster binding
HQN62_RS04645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HQN62_RS04650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HQN62_RS04655	COG2255	four-way junction helicase activity
HQN62_RS04660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HQN62_RS04680	COG1609	Transcriptional regulator
HQN62_RS04710	COG0366	Alpha amylase catalytic
HQN62_RS04715	COG0366	Alpha amylase catalytic
HQN62_RS04720	COG0366	Alpha amylase catalytic
HQN62_RS04730	COG2814	Major facilitator Superfamily
HQN62_RS04735	COG1621	beta-fructofuranosidase activity
HQN62_RS04745	COG4771	TonB-dependent receptor
HQN62_RS04780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQN62_RS04785	COG0366	Alpha amylase catalytic
HQN62_RS04800	COG0517	IMP dehydrogenase activity
HQN62_RS04810	COG0632	four-way junction helicase activity
HQN62_RS04820	COG0509	glycine decarboxylation via glycine cleavage system
HQN62_RS04830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HQN62_RS04845	COG0109	protoheme IX farnesyltransferase activity
HQN62_RS04850	COG1845	cytochrome c oxidase, subunit III
HQN62_RS04855	COG1845	cytochrome c oxidase, subunit III
HQN62_RS04870	COG1999	signal sequence binding
HQN62_RS04875	COG2322	membrane
HQN62_RS04890	COG1136	(ABC) transporter
HQN62_RS04890	COG0577	efflux transmembrane transporter activity
HQN62_RS04895	COG1136	(ABC) transporter
HQN62_RS04895	COG0577	efflux transmembrane transporter activity
HQN62_RS04900	COG1136	(ABC) transporter
HQN62_RS04900	COG0577	efflux transmembrane transporter activity
HQN62_RS04920	COG1214	PFAM Peptidase M22, glycoprotease
HQN62_RS04925	COG0668	transmembrane transport
HQN62_RS04945	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HQN62_RS04955	COG3275	phosphorelay sensor kinase activity
HQN62_RS04985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HQN62_RS05015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HQN62_RS05025	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HQN62_RS05030	COG0596	Alpha beta hydrolase
HQN62_RS05035	COG1950	PFAM Membrane protein of
HQN62_RS05050	COG0633	Ferredoxin
HQN62_RS05050	COG3217	Mosc domain protein beta barrel domain protein
HQN62_RS05060	COG0544	peptidyl-prolyl cis-trans isomerase activity
HQN62_RS05070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HQN62_RS05110	COG0616	signal peptide processing
HQN62_RS05115	COG1428	Deoxynucleoside kinase
HQN62_RS05135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQN62_RS05145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQN62_RS05170	COG1519	Transferase
HQN62_RS05170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HQN62_RS05180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQN62_RS05195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HQN62_RS05210	COG0110	maltose O-acetyltransferase activity
HQN62_RS05230	COG1741	Belongs to the pirin family
HQN62_RS05255	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HQN62_RS05265	COG0436	Aminotransferase
HQN62_RS05270	COG3239	Fatty acid desaturase
HQN62_RS05275	COG0357	Ribosomal RNA small subunit methyltransferase G
HQN62_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
HQN62_RS05285	COG2967	ApaG domain
HQN62_RS05295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HQN62_RS05315	COG2733	membrane
HQN62_RS05335	COG2989	Protein conserved in bacteria
HQN62_RS05355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HQN62_RS05360	COG0427	acetyl-CoA hydrolase
HQN62_RS05385	COG3340	Belongs to the peptidase S51 family
HQN62_RS05415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQN62_RS05420	COG0671	phosphoesterase, PA-phosphatase related
HQN62_RS05460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HQN62_RS05490	COG0358	DNA primase activity
HQN62_RS05500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HQN62_RS05515	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HQN62_RS05525	COG2001	Belongs to the MraZ family
HQN62_RS05530	COG0275	rRNA processing
HQN62_RS05540	COG0768	penicillin binding
HQN62_RS05545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQN62_RS05550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HQN62_RS05555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HQN62_RS05560	COG0772	Belongs to the SEDS family
HQN62_RS05565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HQN62_RS05570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQN62_RS05585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HQN62_RS05590	COG1610	YqeY-like protein
HQN62_RS05605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HQN62_RS05605	COG0617	tRNA 3'-terminal CCA addition
HQN62_RS05605	COG3620	sequence-specific DNA binding
HQN62_RS05610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HQN62_RS05615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQN62_RS05625	COG3279	Response regulator of the LytR AlgR family
HQN62_RS05630	COG2205	protein histidine kinase activity
HQN62_RS05670	COG1185	polyribonucleotide nucleotidyltransferase activity
HQN62_RS05675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HQN62_RS05700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HQN62_RS05720	COG0586	Pfam SNARE associated Golgi protein
HQN62_RS05730	COG0459	protein refolding
HQN62_RS05735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HQN62_RS05770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQN62_RS05775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HQN62_RS05790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQN62_RS05820	COG0488	(ABC) transporter
HQN62_RS05830	COG1597	lipid kinase activity
HQN62_RS05845	COG2154	pterin-4-alpha-carbinolamine dehydratase
HQN62_RS05860	COG1629	transport
HQN62_RS05865	COG0702	epimerase
HQN62_RS05880	COG3118	belongs to the thioredoxin family
HQN62_RS05885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQN62_RS05890	COG2855	membrane
HQN62_RS05900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQN62_RS05905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HQN62_RS05925	COG0564	pseudouridine synthase activity
HQN62_RS05940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HQN62_RS05950	COG1160	GTP binding
HQN62_RS05965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HQN62_RS05970	COG0581	inorganic phosphate transmembrane transporter activity
HQN62_RS05975	COG0573	inorganic phosphate transmembrane transporter activity
HQN62_RS05985	COG4771	TonB-dependent receptor
HQN62_RS05990	COG1959	2 iron, 2 sulfur cluster binding
HQN62_RS06010	COG1704	LemA family
HQN62_RS06020	COG1196	nuclear chromosome segregation
HQN62_RS06020	COG0741	lytic transglycosylase activity
HQN62_RS06020	COG0739	heme binding
HQN62_RS06025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HQN62_RS06045	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQN62_RS06065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HQN62_RS06080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HQN62_RS06085	COG1388	LysM domain
HQN62_RS06085	COG0791	NLP P60 protein
HQN62_RS06090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQN62_RS06135	COG0303	'Molybdopterin
HQN62_RS06150	COG0346	lactoylglutathione lyase activity
HQN62_RS06160	COG0628	permease
HQN62_RS06165	COG0297	glycogen (starch) synthase activity
HQN62_RS06180	COG0746	molybdenum cofactor guanylyltransferase activity
HQN62_RS06200	COG0315	cyclic pyranopterin monophosphate synthase activity
HQN62_RS06200	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQN62_RS06205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HQN62_RS06210	COG1242	4 iron, 4 sulfur cluster binding
HQN62_RS06225	COG0243	molybdopterin cofactor binding
HQN62_RS06255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HQN62_RS06260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HQN62_RS06310	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HQN62_RS06315	COG2010	Cytochrome c
HQN62_RS06320	COG3256	nitric oxide reductase
HQN62_RS06325	COG0714	Associated with various cellular activities
HQN62_RS06330	COG4548	von Willebrand factor, type A
HQN62_RS06340	COG1845	cytochrome c oxidase, subunit III
HQN62_RS06360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQN62_RS06390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HQN62_RS06400	COG0321	lipoyl(octanoyl) transferase activity
HQN62_RS06405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HQN62_RS06420	COG2176	DNA-directed DNA polymerase activity
HQN62_RS06435	COG0531	amino acid
HQN62_RS06445	COG1960	acyl-CoA dehydrogenase activity
HQN62_RS06450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HQN62_RS06455	COG4974	Belongs to the 'phage' integrase family
HQN62_RS06480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQN62_RS06500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HQN62_RS06505	COG0081	regulation of translation
HQN62_RS06510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HQN62_RS06515	COG0222	ribosome binding
HQN62_RS06520	COG0085	RNA polymerase activity
HQN62_RS06525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HQN62_RS06540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HQN62_RS06550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQN62_RS06555	COG0714	Associated with various cellular activities
HQN62_RS06560	COG1049	propionate catabolic process, 2-methylcitrate cycle
HQN62_RS06595	COG1272	protein, Hemolysin III
HQN62_RS06600	COG0791	NLP P60 protein
HQN62_RS06605	COG0531	amino acid
HQN62_RS06610	COG0686	Belongs to the AlaDH PNT family
HQN62_RS06615	COG1522	sequence-specific DNA binding
HQN62_RS06625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQN62_RS06630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HQN62_RS06640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQN62_RS06645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HQN62_RS06660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQN62_RS06660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQN62_RS06665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQN62_RS06675	COG0572	uridine kinase
HQN62_RS06715	COG2003	Belongs to the UPF0758 family
HQN62_RS06760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HQN62_RS06815	COG4974	Belongs to the 'phage' integrase family
HQN62_RS06845	COG0739	heme binding
HQN62_RS06870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HQN62_RS06875	COG0484	heat shock protein binding
HQN62_RS06880	COG4152	abc transporter atp-binding protein
HQN62_RS06905	COG0561	phosphatase activity
HQN62_RS06920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQN62_RS06930	COG0300	oxidoreductase activity
HQN62_RS06945	COG1858	cytochrome C peroxidase
HQN62_RS06955	COG0534	Mate efflux family protein
HQN62_RS06980	COG0463	Glycosyl transferase, family 2
HQN62_RS06985	COG1368	sulfuric ester hydrolase activity
HQN62_RS06990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HQN62_RS06995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQN62_RS07000	COG1703	isobutyryl-CoA mutase activity
HQN62_RS07010	COG1959	2 iron, 2 sulfur cluster binding
HQN62_RS07020	COG0450	alkyl hydroperoxide reductase
HQN62_RS07025	COG0494	nUDIX hydrolase
HQN62_RS07030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HQN62_RS07035	COG0735	belongs to the Fur family
HQN62_RS07040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQN62_RS07045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HQN62_RS07050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQN62_RS07055	COG2860	membrane
HQN62_RS07080	COG1216	Glycosyl transferase, family 2
HQN62_RS07085	COG0438	transferase activity, transferring glycosyl groups
HQN62_RS07095	COG0438	transferase activity, transferring glycosyl groups
HQN62_RS07105	COG2884	Cell division ATP-binding protein ftsE
HQN62_RS07130	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HQN62_RS07140	COG0154	amidase activity
HQN62_RS07155	COG0187	DNA topoisomerase II activity
HQN62_RS07165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQN62_RS07170	COG0583	DNA-binding transcription factor activity
HQN62_RS07175	COG2249	NAD(P)H dehydrogenase (quinone) activity
HQN62_RS07185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HQN62_RS07190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HQN62_RS07195	COG0215	cysteine-tRNA ligase activity
HQN62_RS07205	COG0302	gtp cyclohydrolase
HQN62_RS07210	COG0436	Aminotransferase
HQN62_RS07225	COG0525	valine-tRNA ligase activity
HQN62_RS07270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HQN62_RS07280	COG0284	orotidine-5'-phosphate decarboxylase activity
HQN62_RS07285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQN62_RS07290	COG2267	carboxylic ester hydrolase activity
HQN62_RS07305	COG2345	Transcriptional regulator
HQN62_RS07310	COG0788	formyltetrahydrofolate deformylase activity
HQN62_RS07315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQN62_RS07315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQN62_RS07315	COG1703	isobutyryl-CoA mutase activity
HQN62_RS07350	COG0174	glutamine synthetase
HQN62_RS07385	COG1462	curli production assembly transport component CsgG
HQN62_RS07400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HQN62_RS07420	COG5002	protein histidine kinase activity
HQN62_RS07425	COG2202	Pas domain
HQN62_RS07425	COG2205	protein histidine kinase activity
HQN62_RS07430	COG2205	protein histidine kinase activity
HQN62_RS07430	COG2202	Pas domain
HQN62_RS07440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQN62_RS07445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQN62_RS07455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HQN62_RS07465	COG0038	chloride channel
HQN62_RS07490	COG0519	Catalyzes the synthesis of GMP from XMP
HQN62_RS07490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HQN62_RS07510	COG3530	Putative quorum-sensing-regulated virulence factor
HQN62_RS07515	COG0504	CTP synthase activity
HQN62_RS07520	COG0706	membrane insertase activity
HQN62_RS07525	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HQN62_RS07530	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HQN62_RS07540	COG0482	sulfurtransferase activity
HQN62_RS07575	COG0019	diaminopimelate decarboxylase activity
HQN62_RS07585	COG0069	glutamate synthase activity
HQN62_RS07585	COG0070	glutamate synthase
HQN62_RS07585	COG0067	glutamate synthase
HQN62_RS07590	COG0045	succinate-CoA ligase (ADP-forming) activity
HQN62_RS07595	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HQN62_RS07600	COG1196	nuclear chromosome segregation
HQN62_RS07600	COG3264	Mechanosensitive ion channel
HQN62_RS07605	COG0702	epimerase
HQN62_RS07620	COG2819	hydrolase of the alpha beta superfamily
HQN62_RS07625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HQN62_RS07630	COG0556	nucleotide-excision repair
HQN62_RS07645	COG0596	Alpha beta hydrolase
HQN62_RS07650	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HQN62_RS07675	COG0335	large ribosomal subunit rRNA binding
HQN62_RS07685	COG0336	Belongs to the RNA methyltransferase TrmD family
HQN62_RS07715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQN62_RS07720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQN62_RS07740	COG2897	thiosulfate sulfurtransferase activity
HQN62_RS07755	COG0156	8-amino-7-oxononanoate synthase activity
HQN62_RS07765	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HQN62_RS07800	COG1132	(ABC) transporter
HQN62_RS07805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HQN62_RS07810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQN62_RS07815	COG1862	Preprotein translocase
HQN62_RS07835	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQN62_RS07855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HQN62_RS07905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HQN62_RS07920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HQN62_RS07925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HQN62_RS07955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQN62_RS07965	COG2706	6-phosphogluconolactonase activity
HQN62_RS07970	COG0513	Belongs to the DEAD box helicase family
HQN62_RS07975	COG0745	RESPONSE REGULATOR receiver
HQN62_RS08010	COG1136	(ABC) transporter
HQN62_RS08035	COG4771	TonB-dependent receptor
HQN62_RS08050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQN62_RS08060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HQN62_RS08065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQN62_RS08080	COG0784	Response regulator, receiver
HQN62_RS08080	COG2205	protein histidine kinase activity
HQN62_RS08095	COG4804	nuclease activity
HQN62_RS08120	COG0861	Integral membrane protein TerC family
HQN62_RS08145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HQN62_RS08160	COG2226	methyltransferase
HQN62_RS08165	COG0116	Belongs to the methyltransferase superfamily
HQN62_RS08195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQN62_RS08215	COG0628	permease
HQN62_RS08220	COG1764	response to oxidative stress
HQN62_RS08235	COG0667	Aldo Keto reductase
HQN62_RS08245	COG1045	serine acetyltransferase
HQN62_RS08265	COG0076	glutamate decarboxylase activity
HQN62_RS08285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQN62_RS08295	COG1132	(ABC) transporter
HQN62_RS08300	COG0101	tRNA pseudouridine synthase activity
HQN62_RS08310	COG4585	Histidine kinase
HQN62_RS08315	COG2197	response regulator
HQN62_RS08330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQN62_RS08330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQN62_RS08335	COG3158	transport of potassium into the cell
HQN62_RS08360	COG1595	DNA-templated transcription, initiation
HQN62_RS08385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQN62_RS08385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HQN62_RS08405	COG0783	Belongs to the Dps family
HQN62_RS08420	COG0288	reversible hydration of carbon dioxide
HQN62_RS08435	COG2032	superoxide dismutase activity
HQN62_RS08495	COG0628	permease
HQN62_RS08505	COG1960	acyl-CoA dehydrogenase activity
HQN62_RS08510	COG0183	Belongs to the thiolase family
HQN62_RS08515	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQN62_RS08515	COG1024	Enoyl-CoA hydratase
HQN62_RS08520	COG1846	Transcriptional regulator
HQN62_RS08525	COG2267	carboxylic ester hydrolase activity
HQN62_RS08530	COG1022	Amp-dependent synthetase and ligase
HQN62_RS08555	COG2050	protein possibly involved in aromatic compounds catabolism
HQN62_RS08560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQN62_RS08565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HQN62_RS08575	COG3422	double-strand break repair
HQN62_RS08580	COG3292	Two component regulator propeller
HQN62_RS08580	COG2205	protein histidine kinase activity
HQN62_RS08580	COG0745	RESPONSE REGULATOR receiver
HQN62_RS08600	COG4242	Belongs to the peptidase S51 family
HQN62_RS08610	COG1522	sequence-specific DNA binding
HQN62_RS08615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HQN62_RS08620	COG0010	Belongs to the arginase family
HQN62_RS08625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQN62_RS08625	COG1648	precorrin-2 dehydrogenase activity
HQN62_RS08650	COG4221	oxidoreductase activity
HQN62_RS08735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQN62_RS08755	COG3177	Filamentation induced by cAMP protein fic
HQN62_RS08790	COG4115	mRNA cleavage
HQN62_RS08795	COG2161	toxin-antitoxin pair type II binding
HQN62_RS08855	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS08900	COG4974	Belongs to the 'phage' integrase family
HQN62_RS08905	COG1773	rubredoxin
HQN62_RS08910	COG0243	molybdopterin cofactor binding
HQN62_RS08915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HQN62_RS08925	COG2197	response regulator
HQN62_RS08945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQN62_RS08955	COG0656	L-ascorbic acid biosynthetic process
HQN62_RS08960	COG0667	Aldo Keto reductase
HQN62_RS08985	COG1073	alpha beta
HQN62_RS09005	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HQN62_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS09065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQN62_RS09070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQN62_RS09085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQN62_RS09110	COG1131	(ABC) transporter
HQN62_RS09135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQN62_RS09140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQN62_RS09150	COG0726	polysaccharide deacetylase
HQN62_RS09170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQN62_RS09190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQN62_RS09200	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HQN62_RS09215	COG2217	Heavy metal translocating P-type atpase
HQN62_RS09220	COG1741	Belongs to the pirin family
HQN62_RS09240	COG1674	ftsk spoiiie
HQN62_RS09255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQN62_RS09255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQN62_RS09370	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HQN62_RS09375	COG0514	ATP-dependent DNA helicase (RecQ)
HQN62_RS09445	COG1401	restriction endodeoxyribonuclease activity
HQN62_RS09495	COG0514	ATP-dependent DNA helicase (RecQ)
HQN62_RS09515	COG3292	Two component regulator propeller
HQN62_RS09515	COG2205	protein histidine kinase activity
HQN62_RS09515	COG0745	RESPONSE REGULATOR receiver
HQN62_RS09520	COG2814	Major facilitator Superfamily
HQN62_RS09525	COG1621	beta-fructofuranosidase activity
HQN62_RS09530	COG4771	TonB-dependent receptor
HQN62_RS09535	COG0702	epimerase
HQN62_RS09550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQN62_RS09565	COG0587	DNA-directed DNA polymerase activity
HQN62_RS09575	COG1396	sequence-specific DNA binding
HQN62_RS09610	COG4771	TonB-dependent receptor
HQN62_RS09615	COG0702	epimerase
HQN62_RS09630	COG2271	Major facilitator Superfamily
HQN62_RS09650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQN62_RS09660	COG0363	glucosamine-6-phosphate deaminase activity
HQN62_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS09670	COG2721	sulfolactate sulfo-lyase activity
HQN62_RS09675	COG0738	Major facilitator superfamily
HQN62_RS09680	COG2169	Transcriptional regulator
HQN62_RS09685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HQN62_RS09705	COG3142	Participates in the control of copper homeostasis
HQN62_RS09710	COG1446	asparaginase
HQN62_RS09735	COG3537	Alpha-1,2-mannosidase
HQN62_RS09745	COG3537	Alpha-1,2-mannosidase
HQN62_RS09775	COG3254	rhamnose metabolic process
HQN62_RS09780	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS09790	COG3250	beta-galactosidase activity
HQN62_RS09795	COG0505	Belongs to the CarA family
HQN62_RS09805	COG1472	Belongs to the glycosyl hydrolase 3 family
HQN62_RS09820	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HQN62_RS09825	COG1472	Belongs to the glycosyl hydrolase 3 family
HQN62_RS09835	COG1629	transport
HQN62_RS09835	COG4206	TonB-dependent receptor
HQN62_RS09860	COG2188	Transcriptional regulator
HQN62_RS09870	COG2814	Major facilitator Superfamily
HQN62_RS09905	COG0247	lactate metabolic process
HQN62_RS09910	COG1139	Iron-sulfur cluster binding protein
HQN62_RS09915	COG1556	Lactate utilization protein
HQN62_RS09920	COG0179	Fumarylacetoacetate (FAA) hydrolase
HQN62_RS09930	COG0363	glucosamine-6-phosphate deaminase activity
HQN62_RS09935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HQN62_RS09960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQN62_RS09965	COG0450	alkyl hydroperoxide reductase
HQN62_RS09970	COG1472	Belongs to the glycosyl hydrolase 3 family
HQN62_RS09975	COG2211	Major facilitator Superfamily
HQN62_RS09980	COG1649	PFAM Uncharacterised BCR, COG1649
HQN62_RS10045	COG0531	amino acid
HQN62_RS10050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQN62_RS10065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQN62_RS10070	COG0037	tRNA processing
HQN62_RS10075	COG4232	protein-disulfide reductase activity
HQN62_RS10080	COG0330	HflC and HflK could
HQN62_RS10085	COG2226	methyltransferase
HQN62_RS10090	COG0004	ammonium transporteR
HQN62_RS10095	COG0004	ammonium transporteR
HQN62_RS10100	COG0156	8-amino-7-oxononanoate synthase activity
HQN62_RS10105	COG4948	Mandelate Racemase Muconate Lactonizing
HQN62_RS10140	COG0673	inositol 2-dehydrogenase activity
HQN62_RS10145	COG0606	chelatase, subunit chli
HQN62_RS10155	COG0513	Belongs to the DEAD box helicase family
HQN62_RS10160	COG2321	neutral zinc metallopeptidase
HQN62_RS10165	COG4999	Histidine kinase
HQN62_RS10165	COG3850	Histidine kinase
HQN62_RS10165	COG3437	response regulator, receiver
HQN62_RS10165	COG2205	protein histidine kinase activity
HQN62_RS10175	COG1012	belongs to the aldehyde dehydrogenase family
HQN62_RS10180	COG0564	pseudouridine synthase activity
HQN62_RS10185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HQN62_RS10190	COG2204	response regulator
HQN62_RS10210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HQN62_RS10215	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HQN62_RS10220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HQN62_RS10230	COG2205	protein histidine kinase activity
HQN62_RS10235	COG5002	protein histidine kinase activity
HQN62_RS10240	COG2205	protein histidine kinase activity
HQN62_RS10250	COG3158	transport of potassium into the cell
HQN62_RS10255	COG1760	l-serine dehydratase
HQN62_RS10275	COG1393	Belongs to the ArsC family
HQN62_RS10280	COG1266	CAAX protease self-immunity
HQN62_RS10295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQN62_RS10325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HQN62_RS10345	COG0217	transcriptional regulatory protein
HQN62_RS10350	COG0793	Belongs to the peptidase S41A family
HQN62_RS10355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HQN62_RS10375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HQN62_RS10445	COG0826	peptidase U32
HQN62_RS10460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HQN62_RS10510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HQN62_RS10515	COG0083	homoserine kinase activity
HQN62_RS10530	COG2986	histidine ammonia-lyase
HQN62_RS10540	COG0306	phosphate transporter
HQN62_RS10545	COG2323	membrane
HQN62_RS10550	COG0189	ligase activity
HQN62_RS10550	COG4067	protein conserved in archaea
HQN62_RS10555	COG0542	response to heat
HQN62_RS10575	COG0791	NLP P60 protein
HQN62_RS10580	COG0183	Belongs to the thiolase family
HQN62_RS10620	COG0628	permease
HQN62_RS10640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HQN62_RS10645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HQN62_RS10655	COG0205	6-phosphofructokinase activity
HQN62_RS10660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQN62_RS10675	COG0251	oxidation-reduction process
HQN62_RS10685	COG0860	N-Acetylmuramoyl-L-alanine amidase
HQN62_RS10690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HQN62_RS10695	COG0247	lactate metabolic process
HQN62_RS10695	COG2181	nitrate reductase activity
HQN62_RS10700	COG0247	lactate metabolic process
HQN62_RS10700	COG2181	nitrate reductase activity
HQN62_RS10705	COG0671	phosphoesterase, PA-phosphatase related
HQN62_RS10715	COG0671	phosphoesterase, PA-phosphatase related
HQN62_RS10735	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQN62_RS10750	COG2217	Heavy metal translocating P-type atpase
HQN62_RS10755	COG0438	transferase activity, transferring glycosyl groups
HQN62_RS10770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HQN62_RS10775	COG1301	dicarboxylic acid transport
HQN62_RS10780	COG0784	Response regulator, receiver
HQN62_RS10780	COG2205	protein histidine kinase activity
HQN62_RS10785	COG0513	Belongs to the DEAD box helicase family
HQN62_RS10790	COG0010	Belongs to the arginase family
HQN62_RS10800	COG1228	amidohydrolase
HQN62_RS10815	COG0300	oxidoreductase activity
HQN62_RS10825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQN62_RS10835	COG3279	Response regulator of the LytR AlgR family
HQN62_RS10840	COG3275	phosphorelay sensor kinase activity
HQN62_RS10845	COG1629	transport
HQN62_RS10855	COG0363	glucosamine-6-phosphate deaminase activity
HQN62_RS10860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HQN62_RS10870	COG0488	(ABC) transporter
HQN62_RS10875	COG2311	Membrane
HQN62_RS10880	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HQN62_RS10885	COG0540	Belongs to the ATCase OTCase family
HQN62_RS10895	COG1234	tRNA 3'-trailer cleavage
HQN62_RS10900	COG0259	pyridoxamine-phosphate oxidase activity
HQN62_RS10945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HQN62_RS10950	COG0248	Ppx GppA phosphatase
HQN62_RS10960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HQN62_RS11005	COG3237	CsbD-like
HQN62_RS11035	COG1127	ABC transporter
HQN62_RS11040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQN62_RS11055	COG2885	chlorophyll binding
HQN62_RS11055	COG3047	cAMP biosynthetic process
HQN62_RS11060	COG0628	permease
HQN62_RS11065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQN62_RS11075	COG0783	Belongs to the Dps family
HQN62_RS11080	COG0588	phosphoglycerate mutase activity
HQN62_RS11095	COG5002	protein histidine kinase activity
HQN62_RS11095	COG2198	Histidine kinase
HQN62_RS11095	COG0784	Response regulator, receiver
HQN62_RS11100	COG2207	Transcriptional regulator
HQN62_RS11115	COG0022	dehydrogenase e1 component
HQN62_RS11125	COG1611	Belongs to the LOG family
HQN62_RS11130	COG2852	Protein conserved in bacteria
HQN62_RS11135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HQN62_RS11145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQN62_RS11155	COG0405	Gamma-glutamyltransferase
HQN62_RS11160	COG0405	Gamma-glutamyltransferase
HQN62_RS11170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQN62_RS11195	COG0705	Rhomboid family
HQN62_RS11205	COG0531	amino acid
HQN62_RS11215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQN62_RS11225	COG0484	heat shock protein binding
HQN62_RS11240	COG2201	protein-glutamate methylesterase activity
HQN62_RS11245	COG5002	protein histidine kinase activity
HQN62_RS11260	COG3012	SEC-C Motif Domain Protein
HQN62_RS11340	COG0116	Belongs to the methyltransferase superfamily
HQN62_RS11340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQN62_RS11350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HQN62_RS11355	COG3384	dioxygenase
HQN62_RS11365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQN62_RS11395	COG1522	sequence-specific DNA binding
HQN62_RS11400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HQN62_RS11415	COG0514	ATP-dependent DNA helicase (RecQ)
HQN62_RS11440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQN62_RS11450	COG1132	(ABC) transporter
HQN62_RS11475	COG1078	dGTPase activity
HQN62_RS11480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQN62_RS11485	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HQN62_RS11485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQN62_RS11490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQN62_RS11495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HQN62_RS11500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQN62_RS11510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HQN62_RS11520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQN62_RS11530	COG0297	glycogen (starch) synthase activity
HQN62_RS11535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HQN62_RS11540	COG0366	Alpha amylase catalytic
HQN62_RS11550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HQN62_RS11560	COG2270	Major facilitator Superfamily
HQN62_RS11580	COG1595	DNA-templated transcription, initiation
HQN62_RS11590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HQN62_RS11605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HQN62_RS11610	COG2211	Major facilitator Superfamily
HQN62_RS11640	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HQN62_RS11650	COG3781	membrane
HQN62_RS11660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQN62_RS11665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQN62_RS11670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HQN62_RS11690	COG0006	proline dipeptidase activity
HQN62_RS11770	COG0009	L-threonylcarbamoyladenylate synthase
HQN62_RS11795	COG1523	belongs to the glycosyl hydrolase 13 family
HQN62_RS11805	COG0488	(ABC) transporter
HQN62_RS11810	COG3011	Protein conserved in bacteria
HQN62_RS11820	COG1193	negative regulation of DNA recombination
HQN62_RS11825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HQN62_RS11860	COG0022	dehydrogenase e1 component
HQN62_RS11865	COG2985	domain, Protein
HQN62_RS11865	COG0569	domain protein
HQN62_RS11870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQN62_RS11875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HQN62_RS11880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HQN62_RS11885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HQN62_RS11890	COG0131	Imidazoleglycerol-phosphate dehydratase
HQN62_RS11900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HQN62_RS11905	COG0107	imidazoleglycerol-phosphate synthase activity
HQN62_RS11910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HQN62_RS11910	COG0140	phosphoribosyl-ATP diphosphatase activity
HQN62_RS11925	COG1082	Xylose isomerase domain protein TIM barrel
HQN62_RS11930	COG2211	Major facilitator Superfamily
HQN62_RS11940	COG0673	inositol 2-dehydrogenase activity
HQN62_RS11945	COG4654	Cytochrome c, class I
HQN62_RS11955	COG0673	inositol 2-dehydrogenase activity
HQN62_RS11975	COG1607	acyl-coa hydrolase
HQN62_RS11980	COG0668	transmembrane transport
HQN62_RS12005	COG1252	NADH dehydrogenase
HQN62_RS12015	COG4251	negative regulation of phosphorylation
HQN62_RS12020	COG2814	Major facilitator Superfamily
HQN62_RS12105	COG0736	holo-[acyl-carrier-protein] synthase activity
HQN62_RS12110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQN62_RS12115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQN62_RS12120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQN62_RS12125	COG3424	synthase
HQN62_RS12145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HQN62_RS12155	COG1584	GPR1 FUN34 yaaH family protein
HQN62_RS12170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HQN62_RS12175	COG1575	Belongs to the MenA family. Type 1 subfamily
HQN62_RS12230	COG1363	Peptidase, m42
HQN62_RS12235	COG1271	oxidase subunit
HQN62_RS12240	COG1294	oxidase, subunit
HQN62_RS12245	COG3647	Membrane
HQN62_RS12260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQN62_RS12265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HQN62_RS12270	COG0440	acetolactate synthase activity
HQN62_RS12275	COG0028	Belongs to the TPP enzyme family
HQN62_RS12280	COG0129	dihydroxy-acid dehydratase activity
HQN62_RS12285	COG0473	3-isopropylmalate dehydrogenase activity
HQN62_RS12290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HQN62_RS12320	COG5002	protein histidine kinase activity
HQN62_RS12325	COG0745	RESPONSE REGULATOR receiver
HQN62_RS12345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQN62_RS12350	COG1368	sulfuric ester hydrolase activity
HQN62_RS12365	COG2855	membrane
HQN62_RS12370	COG0583	DNA-binding transcription factor activity
HQN62_RS12390	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS12405	COG0697	spore germination
HQN62_RS12410	COG2204	response regulator
HQN62_RS12415	COG0802	atpase or kinase
HQN62_RS12425	COG0686	Belongs to the AlaDH PNT family
HQN62_RS12435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HQN62_RS12445	COG0561	phosphatase activity
HQN62_RS12450	COG1702	phosphate starvation-inducible protein PhoH
HQN62_RS12485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQN62_RS12495	COG0589	response to stress
HQN62_RS12500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HQN62_RS12520	COG0673	inositol 2-dehydrogenase activity
HQN62_RS12535	COG0457	Tetratricopeptide repeat
HQN62_RS12545	COG3258	Cytochrome c
HQN62_RS12555	COG0702	epimerase
HQN62_RS12560	COG4771	TonB-dependent receptor
HQN62_RS12570	COG0156	8-amino-7-oxononanoate synthase activity
HQN62_RS12595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQN62_RS12605	COG0363	glucosamine-6-phosphate deaminase activity
HQN62_RS12615	COG0366	Alpha amylase catalytic
HQN62_RS12630	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HQN62_RS12640	COG0702	epimerase
HQN62_RS12645	COG4771	TonB-dependent receptor
HQN62_RS12650	COG3292	Two component regulator propeller
HQN62_RS12650	COG2205	protein histidine kinase activity
HQN62_RS12650	COG0745	RESPONSE REGULATOR receiver
HQN62_RS12670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HQN62_RS12675	COG1247	-acetyltransferase
HQN62_RS12685	COG0386	Belongs to the glutathione peroxidase family
HQN62_RS12690	COG4206	TonB-dependent receptor
HQN62_RS12710	COG1595	DNA-templated transcription, initiation
HQN62_RS12720	COG1333	cytochrome c biogenesis protein
HQN62_RS12720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQN62_RS12730	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HQN62_RS12740	COG0424	maF-like protein
HQN62_RS12790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HQN62_RS12805	COG2814	Major facilitator Superfamily
HQN62_RS12825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HQN62_RS12860	COG2176	DNA-directed DNA polymerase activity
HQN62_RS12900	COG1070	Carbohydrate kinase
HQN62_RS12920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQN62_RS12940	COG1247	-acetyltransferase
HQN62_RS12950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HQN62_RS12990	COG0137	argininosuccinate synthase activity
HQN62_RS12995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HQN62_RS13000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HQN62_RS13005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HQN62_RS13010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HQN62_RS13015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQN62_RS13020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HQN62_RS13025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQN62_RS13030	COG0165	Argininosuccinate lyase
HQN62_RS13055	COG0542	response to heat
HQN62_RS13095	COG0546	phosphoglycolate phosphatase activity
HQN62_RS13115	COG2354	Protein conserved in bacteria
HQN62_RS13120	COG1132	(ABC) transporter
HQN62_RS13130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HQN62_RS13165	COG2957	Belongs to the agmatine deiminase family
HQN62_RS13180	COG0596	Alpha beta hydrolase
HQN62_RS13200	COG4628	conserved protein (DUF2132)
HQN62_RS13205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HQN62_RS13215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HQN62_RS13220	COG0673	inositol 2-dehydrogenase activity
HQN62_RS13225	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQN62_RS13230	COG0537	adenosine 5'-monophosphoramidase activity
HQN62_RS13235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HQN62_RS13245	COG0322	excinuclease ABC activity
HQN62_RS13250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQN62_RS13255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HQN62_RS13285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQN62_RS13290	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQN62_RS13295	COG0497	DNA recombination
HQN62_RS13320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQN62_RS13335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQN62_RS13345	COG0359	binds to the 23S rRNA
HQN62_RS13350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HQN62_RS13355	COG0360	Binds together with S18 to 16S ribosomal RNA
HQN62_RS13360	COG3279	Response regulator of the LytR AlgR family
HQN62_RS13365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HQN62_RS13395	COG1082	Xylose isomerase domain protein TIM barrel
HQN62_RS13425	COG0702	epimerase
HQN62_RS13430	COG4771	TonB-dependent receptor
HQN62_RS13440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HQN62_RS13445	COG0857	belongs to the CobB CobQ family
HQN62_RS13445	COG0280	phosphate acetyltransferase
HQN62_RS13450	COG0598	Magnesium transport protein CorA
HQN62_RS13455	COG0443	Heat shock 70 kDa protein
HQN62_RS13460	COG0730	response to heat
HQN62_RS13465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HQN62_RS13480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HQN62_RS13495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQN62_RS13500	COG0149	triose-phosphate isomerase activity
HQN62_RS13510	COG2264	protein methyltransferase activity
HQN62_RS13545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HQN62_RS13570	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HQN62_RS13585	COG4452	Inner membrane protein CreD
HQN62_RS13610	COG1104	cysteine desulfurase activity
HQN62_RS13620	COG1127	ABC transporter
HQN62_RS13625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQN62_RS13635	COG0484	heat shock protein binding
HQN62_RS13640	COG1794	racemase activity, acting on amino acids and derivatives
HQN62_RS13645	COG0612	Peptidase, M16
HQN62_RS13700	COG2826	transposase and inactivated derivatives, IS30 family
HQN62_RS13705	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQN62_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS13755	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS13765	COG3119	arylsulfatase activity
HQN62_RS13830	COG0629	single-stranded DNA binding
HQN62_RS13885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQN62_RS13885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQN62_RS14055	COG4804	nuclease activity
HQN62_RS14060	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HQN62_RS14110	COG0156	8-amino-7-oxononanoate synthase activity
HQN62_RS14145	COG1629	transport
HQN62_RS14175	COG0798	PFAM Bile acid sodium symporter
HQN62_RS14190	COG0640	Transcriptional regulator
HQN62_RS14195	COG2217	Heavy metal translocating P-type atpase
HQN62_RS14225	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQN62_RS14230	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQN62_RS14265	COG2217	Heavy metal translocating P-type atpase
HQN62_RS14285	COG1285	pathogenesis
HQN62_RS14325	COG1012	belongs to the aldehyde dehydrogenase family
HQN62_RS14330	COG1629	transport
HQN62_RS14330	COG4206	TonB-dependent receptor
HQN62_RS14335	COG0702	epimerase
HQN62_RS14340	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HQN62_RS14340	COG3408	Glycogen debranching enzyme
HQN62_RS14350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HQN62_RS14360	COG2423	ornithine cyclodeaminase activity
HQN62_RS14370	COG0006	proline dipeptidase activity
HQN62_RS14380	COG0006	proline dipeptidase activity
HQN62_RS14385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQN62_RS14390	COG3938	Belongs to the proline racemase family
HQN62_RS14435	COG3275	phosphorelay sensor kinase activity
HQN62_RS14450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQN62_RS14465	COG1309	transcriptional regulator
HQN62_RS14470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQN62_RS14480	COG1538	Outer membrane efflux protein
HQN62_RS14485	COG1902	pentaerythritol trinitrate reductase activity
HQN62_RS14495	COG1064	alcohol dehydrogenase
HQN62_RS14515	COG0784	Response regulator, receiver
HQN62_RS14515	COG4191	Histidine kinase
HQN62_RS14520	COG4191	Histidine kinase
HQN62_RS14520	COG0784	Response regulator, receiver
HQN62_RS14535	COG1012	belongs to the aldehyde dehydrogenase family
HQN62_RS14550	COG0730	response to heat
HQN62_RS14555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQN62_RS14555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQN62_RS14575	COG3118	belongs to the thioredoxin family
HQN62_RS14595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQN62_RS14600	COG1131	(ABC) transporter
HQN62_RS14605	COG1131	(ABC) transporter
HQN62_RS14610	COG0842	Transport permease protein
HQN62_RS14615	COG1129	ABC transporter
HQN62_RS14615	COG0842	Transport permease protein
HQN62_RS14630	COG0784	Response regulator, receiver
HQN62_RS14630	COG2205	protein histidine kinase activity
HQN62_RS14630	COG5002	protein histidine kinase activity
HQN62_RS14635	COG5002	protein histidine kinase activity
HQN62_RS14635	COG0784	Response regulator, receiver
HQN62_RS14705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQN62_RS14710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQN62_RS14710	COG0512	Glutamine amidotransferase of anthranilate synthase
HQN62_RS14720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQN62_RS14725	COG0134	indole-3-glycerol-phosphate synthase activity
HQN62_RS14730	COG0135	phosphoribosylanthranilate isomerase activity
HQN62_RS14735	COG0133	tryptophan synthase activity
HQN62_RS14750	COG0159	tryptophan synthase activity
HQN62_RS14755	COG0454	-acetyltransferase
HQN62_RS14765	COG1309	transcriptional regulator
HQN62_RS14785	COG3022	response to hydroperoxide
HQN62_RS14795	COG2814	Major facilitator Superfamily
HQN62_RS14805	COG1119	ATPase activity
HQN62_RS14810	COG0564	pseudouridine synthase activity
HQN62_RS14820	COG1181	Belongs to the D-alanine--D-alanine ligase family
HQN62_RS14835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HQN62_RS14840	COG2824	Alkylphosphonate utilization operon protein PhnA
HQN62_RS14850	COG0513	Belongs to the DEAD box helicase family
HQN62_RS14870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HQN62_RS14880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HQN62_RS14880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HQN62_RS14885	COG0799	negative regulation of ribosome biogenesis
HQN62_RS14890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HQN62_RS14900	COG4589	Belongs to the CDS family
HQN62_RS14905	COG0688	phosphatidylethanolamine metabolic process
HQN62_RS14915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HQN62_RS14920	COG1523	belongs to the glycosyl hydrolase 13 family
HQN62_RS14930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HQN62_RS14940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HQN62_RS14950	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HQN62_RS14960	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HQN62_RS14980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQN62_RS14995	COG0348	domain, Protein
HQN62_RS15010	COG3278	Belongs to the heme-copper respiratory oxidase family
HQN62_RS15025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQN62_RS15030	COG3956	TIGRFAM MazG family protein
HQN62_RS15040	COG0242	peptide deformylase activity
HQN62_RS15045	COG1289	transmembrane transporter activity
HQN62_RS15050	COG0579	oxidoreductase
HQN62_RS15055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HQN62_RS15070	COG2171	N-acyltransferase activity
HQN62_RS15075	COG0463	Glycosyl transferase, family 2
HQN62_RS15090	COG0463	Glycosyl transferase, family 2
HQN62_RS15110	COG0463	Glycosyl transferase, family 2
HQN62_RS15130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HQN62_RS15130	COG0617	tRNA 3'-terminal CCA addition
HQN62_RS15130	COG0517	IMP dehydrogenase activity
HQN62_RS15135	COG1612	heme a metabolic process
HQN62_RS15145	COG3279	Response regulator of the LytR AlgR family
HQN62_RS15160	COG3275	phosphorelay sensor kinase activity
HQN62_RS15200	COG0346	lactoylglutathione lyase activity
HQN62_RS15205	COG0038	chloride channel
HQN62_RS15240	COG1131	(ABC) transporter
HQN62_RS15260	COG2207	Transcriptional regulator
HQN62_RS15260	COG1917	Cupin 2, conserved barrel domain protein
HQN62_RS15270	COG0366	Alpha amylase catalytic
HQN62_RS15275	COG2382	esterase
HQN62_RS15280	COG3537	Alpha-1,2-mannosidase
HQN62_RS15300	COG0268	Binds directly to 16S ribosomal RNA
HQN62_RS15320	COG0442	prolyl-tRNA aminoacylation
HQN62_RS15335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQN62_RS15355	COG0728	peptidoglycan biosynthetic process
HQN62_RS15365	COG0367	asparagine synthase
HQN62_RS15390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQN62_RS15405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQN62_RS15430	COG1012	belongs to the aldehyde dehydrogenase family
HQN62_RS15440	COG2205	protein histidine kinase activity
HQN62_RS15440	COG0784	Response regulator, receiver
HQN62_RS15450	COG3345	alpha-galactosidase
HQN62_RS15455	COG3250	beta-galactosidase activity
HQN62_RS15465	COG0561	phosphatase activity
HQN62_RS15470	COG4771	TonB-dependent receptor
HQN62_RS15475	COG2169	Transcriptional regulator
HQN62_RS15480	COG4124	Belongs to the glycosyl hydrolase 26 family
HQN62_RS15485	COG2211	Major facilitator Superfamily
HQN62_RS15490	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HQN62_RS15495	COG2942	2-epimerase
HQN62_RS15515	COG0667	Aldo Keto reductase
HQN62_RS15540	COG2755	lipolytic protein G-D-S-L family
HQN62_RS15540	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HQN62_RS15570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQN62_RS15575	COG0439	Biotin carboxylase
HQN62_RS15595	COG5658	integral membrane protein
HQN62_RS15600	COG0640	Transcriptional regulator
HQN62_RS15605	COG0477	Major facilitator Superfamily
HQN62_RS15610	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HQN62_RS15620	COG0105	UTP biosynthetic process
HQN62_RS15640	COG0552	protein localization to endoplasmic reticulum
HQN62_RS15650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HQN62_RS15655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HQN62_RS15660	COG1546	Belongs to the CinA family
HQN62_RS15660	COG1058	Belongs to the CinA family
HQN62_RS15670	COG0179	Fumarylacetoacetate (FAA) hydrolase
HQN62_RS15675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQN62_RS15675	COG1199	ATP-dependent helicase activity
HQN62_RS15680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQN62_RS15700	COG0488	(ABC) transporter
HQN62_RS15715	COG0545	Peptidyl-prolyl cis-trans isomerase
HQN62_RS15720	COG0545	Peptidyl-prolyl cis-trans isomerase
HQN62_RS15730	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS15740	COG0288	reversible hydration of carbon dioxide
HQN62_RS15750	COG1136	(ABC) transporter
HQN62_RS15770	COG0653	protein targeting
HQN62_RS15790	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQN62_RS15825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HQN62_RS15865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HQN62_RS15870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HQN62_RS15875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HQN62_RS15880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HQN62_RS15890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HQN62_RS15895	COG0252	asparaginase activity
HQN62_RS15905	COG1027	Aspartate ammonia-lyase
HQN62_RS15910	COG2985	domain, Protein
HQN62_RS15915	COG0281	malic enzyme
HQN62_RS15945	COG0305	Participates in initiation and elongation during chromosome replication
HQN62_RS15950	COG0825	malonyl-CoA metabolic process
HQN62_RS15965	COG0343	queuine tRNA-ribosyltransferase activity
HQN62_RS15985	COG3959	Transketolase, thiamine diphosphate binding domain
HQN62_RS15990	COG3958	Transketolase
HQN62_RS16005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HQN62_RS16010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HQN62_RS16075	COG3409	Peptidoglycan-binding domain 1 protein
HQN62_RS16075	COG0793	Belongs to the peptidase S41A family
HQN62_RS16085	COG4206	TonB-dependent receptor
HQN62_RS16095	COG4115	mRNA cleavage
HQN62_RS16105	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HQN62_RS16110	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HQN62_RS16115	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HQN62_RS16130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HQN62_RS16140	COG1120	ATPase activity
HQN62_RS16155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HQN62_RS16160	COG1187	pseudouridine synthase activity
HQN62_RS16200	COG1607	acyl-coa hydrolase
HQN62_RS16205	COG2353	YceI-like domain
HQN62_RS16210	COG1090	epimerase
HQN62_RS16230	COG0415	Belongs to the DNA photolyase family
HQN62_RS16245	COG0302	gtp cyclohydrolase
HQN62_RS16250	COG0702	epimerase
HQN62_RS16255	COG0415	Belongs to the DNA photolyase family
HQN62_RS16295	COG4651	solute:proton antiporter activity
HQN62_RS16295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HQN62_RS16305	COG2070	2-Nitropropane dioxygenase
HQN62_RS16310	COG0516	GMP reductase activity
HQN62_RS16310	COG0517	IMP dehydrogenase activity
HQN62_RS16315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HQN62_RS16335	COG0167	dihydroorotate dehydrogenase activity
HQN62_RS16370	COG4682	membrane
HQN62_RS16375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HQN62_RS16380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HQN62_RS16410	COG1473	amidohydrolase
HQN62_RS16415	COG0387	Pfam Sodium calcium exchanger
HQN62_RS16440	COG0488	(ABC) transporter
HQN62_RS16450	COG0254	rRNA binding
HQN62_RS16460	COG0463	Glycosyl transferase, family 2
HQN62_RS16465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQN62_RS16470	COG1132	(ABC) transporter
HQN62_RS16490	COG0739	heme binding
HQN62_RS16505	COG1418	mRNA catabolic process
HQN62_RS16510	COG5002	protein histidine kinase activity
HQN62_RS16515	COG4974	Belongs to the 'phage' integrase family
HQN62_RS16525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HQN62_RS16535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HQN62_RS16540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HQN62_RS16560	COG0514	ATP-dependent DNA helicase (RecQ)
HQN62_RS16565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQN62_RS16575	COG1678	Uncharacterized ACR, COG1678
HQN62_RS16615	COG0124	histidyl-tRNA synthetase
HQN62_RS16625	COG2890	protein-(glutamine-N5) methyltransferase activity
HQN62_RS16635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQN62_RS16635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQN62_RS16640	COG1011	Hydrolase
HQN62_RS16645	COG1739	Uncharacterized protein family UPF0029
HQN62_RS16650	COG0824	Thioesterase
HQN62_RS16655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HQN62_RS16660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HQN62_RS16665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HQN62_RS16670	COG0436	Aminotransferase
HQN62_RS16675	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS16680	COG1192	Involved in chromosome partitioning
HQN62_RS16685	COG1475	DNA binding
HQN62_RS16695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HQN62_RS16700	COG0681	Belongs to the peptidase S26 family
HQN62_RS16730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HQN62_RS16740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HQN62_RS16750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HQN62_RS16755	COG3118	belongs to the thioredoxin family
HQN62_RS16765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HQN62_RS16770	COG2808	Putative FMN-binding domain
HQN62_RS16790	COG0501	Belongs to the peptidase M48B family
HQN62_RS16795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HQN62_RS16800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQN62_RS16810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HQN62_RS16815	COG1663	tetraacyldisaccharide 4'-kinase activity
HQN62_RS16820	COG3063	Type IV pilus biogenesis stability protein PilW
HQN62_RS16825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HQN62_RS16840	COG1187	pseudouridine synthase activity
HQN62_RS16845	COG0598	Magnesium transport protein CorA
HQN62_RS16850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HQN62_RS16855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HQN62_RS16870	COG0018	arginyl-trna synthetase
HQN62_RS16885	COG3842	ATPase activity
HQN62_RS16900	COG0326	Molecular chaperone. Has ATPase activity
HQN62_RS16985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HQN62_RS17000	COG2207	Transcriptional regulator
HQN62_RS17020	COG1482	cell wall glycoprotein biosynthetic process
HQN62_RS17025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HQN62_RS17035	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HQN62_RS17045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQN62_RS17050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQN62_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS17065	COG0604	alcohol dehydrogenase
HQN62_RS17065	COG3321	synthase
HQN62_RS17070	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HQN62_RS17080	COG0514	ATP-dependent DNA helicase (RecQ)
HQN62_RS17085	COG0517	IMP dehydrogenase activity
HQN62_RS17085	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQN62_RS17090	COG0805	protein transport
HQN62_RS17095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQN62_RS17100	COG1137	ATPase activity
HQN62_RS17130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQN62_RS17135	COG0438	transferase activity, transferring glycosyl groups
HQN62_RS17220	COG2089	acid synthase
HQN62_RS17255	COG1216	Glycosyl transferase, family 2
HQN62_RS17300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQN62_RS17340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQN62_RS17345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQN62_RS17350	COG1215	transferase activity, transferring glycosyl groups
HQN62_RS17355	COG0438	transferase activity, transferring glycosyl groups
HQN62_RS17370	COG2244	polysaccharide biosynthetic process
HQN62_RS17375	COG0673	inositol 2-dehydrogenase activity
HQN62_RS17390	COG0579	oxidoreductase
HQN62_RS17420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HQN62_RS17425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HQN62_RS17435	COG0489	protein tyrosine kinase activity
HQN62_RS17435	COG3206	protein involved in exopolysaccharide biosynthesis
HQN62_RS17445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HQN62_RS17455	COG2095	MarC family integral membrane protein
HQN62_RS17475	COG0148	phosphopyruvate hydratase activity
HQN62_RS17480	COG0505	Belongs to the CarA family
HQN62_RS17485	COG0203	ribosomal protein L17
HQN62_RS17490	COG0202	RNA polymerase activity
HQN62_RS17495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HQN62_RS17500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HQN62_RS17505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HQN62_RS17510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HQN62_RS17515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HQN62_RS17520	COG0201	protein transport
HQN62_RS17525	COG0200	Binds to the 23S rRNA
HQN62_RS17530	COG1841	ribosomal large subunit assembly
HQN62_RS17535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HQN62_RS17540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HQN62_RS17545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HQN62_RS17550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HQN62_RS17555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HQN62_RS17560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HQN62_RS17565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HQN62_RS17570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HQN62_RS17575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HQN62_RS17580	COG0255	Belongs to the universal ribosomal protein uL29 family
HQN62_RS17585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HQN62_RS17590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HQN62_RS17595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HQN62_RS17600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HQN62_RS17605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HQN62_RS17610	COG0089	rRNA binding
HQN62_RS17615	COG0088	Forms part of the polypeptide exit tunnel
HQN62_RS17620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HQN62_RS17625	COG0051	transcription antitermination factor activity, RNA binding
HQN62_RS17630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HQN62_RS17635	COG0049	tRNA binding
HQN62_RS17640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HQN62_RS17650	COG1629	transport
HQN62_RS17650	COG4206	TonB-dependent receptor
HQN62_RS17660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQN62_RS17670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HQN62_RS17695	COG2003	Belongs to the UPF0758 family
HQN62_RS17705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQN62_RS17715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQN62_RS17725	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HQN62_RS17755	COG3591	Belongs to the peptidase S1B family
HQN62_RS17760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HQN62_RS17765	COG1253	flavin adenine dinucleotide binding
HQN62_RS17770	COG0563	adenylate kinase activity
HQN62_RS17795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HQN62_RS17800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HQN62_RS17810	COG1510	regulation of RNA biosynthetic process
HQN62_RS17850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQN62_RS17850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQN62_RS17860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQN62_RS17875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQN62_RS17880	COG1127	ABC transporter
HQN62_RS17885	COG0697	spore germination
HQN62_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
HQN62_RS17950	COG2207	Transcriptional regulator
HQN62_RS17980	COG1960	acyl-CoA dehydrogenase activity
HQN62_RS18010	COG0811	peptide transport
HQN62_RS18015	COG0285	dihydrofolate synthase activity
HQN62_RS18035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQN62_RS18060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HQN62_RS18245	COG0577	efflux transmembrane transporter activity
HQN62_RS18245	COG1136	(ABC) transporter
HQN62_RS18255	COG0577	efflux transmembrane transporter activity
HQN62_RS18280	COG1472	Belongs to the glycosyl hydrolase 3 family
HQN62_RS18285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HQN62_RS18285	COG2755	lipolytic protein G-D-S-L family
HQN62_RS18290	COG1917	Cupin 2, conserved barrel domain protein
HQN62_RS18290	COG2207	Transcriptional regulator
HQN62_RS18295	COG0110	maltose O-acetyltransferase activity
HQN62_RS18370	COG4771	TonB-dependent receptor
HQN62_RS18380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HQN62_RS18385	COG0515	serine threonine protein kinase
HQN62_RS18385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQN62_RS18400	COG0295	cytidine deaminase activity
HQN62_RS18405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HQN62_RS18475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQN62_RS18485	COG0602	queuosine metabolic process
HQN62_RS18500	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQN62_RS18520	COG0433	COG0433 Predicted ATPase
HQN62_RS18550	COG3844	kynureninase activity
HQN62_RS18555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HQN62_RS18585	COG1490	D-aminoacyl-tRNA deacylase activity
HQN62_RS18590	COG1162	GTPase activity
HQN62_RS18595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HQN62_RS18600	COG0287	Prephenate dehydrogenase
HQN62_RS18605	COG0436	Aminotransferase
HQN62_RS18610	COG0077	Prephenate dehydratase
HQN62_RS18610	COG1605	Chorismate mutase
HQN62_RS18615	COG1301	dicarboxylic acid transport
HQN62_RS18630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQN62_RS18630	COG2207	Transcriptional regulator
HQN62_RS18645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HQN62_RS18670	COG1410	methionine synthase
HQN62_RS18670	COG0646	methionine synthase
HQN62_RS18685	COG0492	ferredoxin-NADP+ reductase activity
HQN62_RS18700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQN62_RS18705	COG2895	sulfate adenylyltransferase (ATP) activity
HQN62_RS18710	COG0175	sulfate reduction
HQN62_RS18715	COG0175	sulfate reduction
HQN62_RS18720	COG1959	2 iron, 2 sulfur cluster binding
HQN62_RS18745	COG0527	aspartate kinase activity
HQN62_RS18745	COG0460	homoserine dehydrogenase
HQN62_RS18750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQN62_RS18760	COG2873	o-acetylhomoserine
HQN62_RS18770	COG0460	homoserine dehydrogenase
HQN62_RS18770	COG0527	aspartate kinase activity
HQN62_RS18775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQN62_RS18785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HQN62_RS18800	COG0772	Belongs to the SEDS family
HQN62_RS18805	COG0768	penicillin binding
HQN62_RS18820	COG1077	Cell shape determining protein MreB Mrl
HQN62_RS18825	COG0138	bifunctional purine biosynthesis protein purh
HQN62_RS18840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HQN62_RS18845	COG0191	fructose-bisphosphate aldolase activity