locus-tag	class	description
F3I61_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F3I61_RS00035	COG0187	DNA topoisomerase II activity
F3I61_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3I61_RS00055	COG0328	RNA-DNA hybrid ribonuclease activity
F3I61_RS00060	COG0423	glycine-tRNA ligase activity
F3I61_RS00080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F3I61_RS00090	COG1774	PSP1 C-terminal conserved region
F3I61_RS00095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F3I61_RS00100	COG1982	Orn Lys Arg decarboxylase major
F3I61_RS00120	COG1217	gtp-binding protein TYPA
F3I61_RS00130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3I61_RS00145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F3I61_RS00150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3I61_RS00155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F3I61_RS00160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F3I61_RS00170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F3I61_RS00175	COG1923	regulation of RNA biosynthetic process
F3I61_RS00185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F3I61_RS00190	COG1799	cell septum assembly
F3I61_RS00200	COG0564	pseudouridine synthase activity
F3I61_RS00205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F3I61_RS00210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F3I61_RS00225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F3I61_RS00245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F3I61_RS00260	COG1215	transferase activity, transferring glycosyl groups
F3I61_RS00265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F3I61_RS00270	COG0492	ferredoxin-NADP+ reductase activity
F3I61_RS00280	COG0071	Belongs to the small heat shock protein (HSP20) family
F3I61_RS00290	COG1228	amidohydrolase
F3I61_RS00295	COG1126	abc transporter atp-binding protein
F3I61_RS00370	COG0629	single-stranded DNA binding
F3I61_RS00380	COG3853	Toxic anion resistance protein (TelA)
F3I61_RS00395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F3I61_RS00400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F3I61_RS00405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F3I61_RS00415	COG1489	DNA binding
F3I61_RS00440	COG4657	Part of a membrane complex involved in electron transport
F3I61_RS00445	COG4658	electron transport chain
F3I61_RS00450	COG4656	Part of a membrane complex involved in electron transport
F3I61_RS00455	COG0561	phosphatase activity
F3I61_RS00460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F3I61_RS00475	COG0745	RESPONSE REGULATOR receiver
F3I61_RS00485	COG2851	Citrate transporter
F3I61_RS00490	COG0288	reversible hydration of carbon dioxide
F3I61_RS00505	COG0346	lactoylglutathione lyase activity
F3I61_RS00515	COG2186	Transcriptional regulator
F3I61_RS00540	COG3959	Transketolase, thiamine diphosphate binding domain
F3I61_RS00545	COG3958	Transketolase
F3I61_RS00550	COG1959	2 iron, 2 sulfur cluster binding
F3I61_RS00555	COG0604	alcohol dehydrogenase
F3I61_RS00555	COG3321	synthase
F3I61_RS00595	COG0740	serine-type endopeptidase activity
F3I61_RS00640	COG2911	Protein conserved in bacteria
F3I61_RS00640	COG1361	Conserved repeat domain
F3I61_RS00640	COG3266	domain, Protein
F3I61_RS00680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F3I61_RS00685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3I61_RS00710	COG0582	viral genome integration into host DNA
F3I61_RS00740	COG1473	amidohydrolase
F3I61_RS00755	COG0395	ABC-type sugar transport system, permease component
F3I61_RS00760	COG1175	transmembrane transport
F3I61_RS00770	COG1609	Transcriptional regulator
F3I61_RS00775	COG3250	beta-galactosidase activity
F3I61_RS00795	COG1288	antiporter activity
F3I61_RS00800	COG1802	Transcriptional regulator
F3I61_RS00805	COG1063	alcohol dehydrogenase
F3I61_RS00810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3I61_RS00815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F3I61_RS00820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F3I61_RS00825	COG1312	Catalyzes the dehydration of D-mannonate
F3I61_RS00830	COG0246	Mannitol dehydrogenase
F3I61_RS00845	COG1063	alcohol dehydrogenase
F3I61_RS00850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3I61_RS00865	COG0246	Mannitol dehydrogenase
F3I61_RS00870	COG2721	sulfolactate sulfo-lyase activity
F3I61_RS00885	COG0800	Aldolase
F3I61_RS00890	COG1414	Transcriptional regulator
F3I61_RS00905	COG2059	Chromate
F3I61_RS00910	COG0641	radical SAM
F3I61_RS00915	COG1609	Transcriptional regulator
F3I61_RS00920	COG3119	arylsulfatase activity
F3I61_RS00940	COG0475	glutathione-regulated potassium exporter activity
F3I61_RS00945	COG1473	amidohydrolase
F3I61_RS00950	COG1737	Transcriptional regulator
F3I61_RS00955	COG1288	antiporter activity
F3I61_RS00960	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F3I61_RS00980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3I61_RS01020	COG1414	Transcriptional regulator
F3I61_RS01025	COG0534	Mate efflux family protein
F3I61_RS01030	COG0475	glutathione-regulated potassium exporter activity
F3I61_RS01040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F3I61_RS01060	COG2207	Transcriptional regulator
F3I61_RS01060	COG0662	Cupin 2, conserved barrel domain protein
F3I61_RS01070	COG1175	transmembrane transport
F3I61_RS01075	COG0395	ABC-type sugar transport system, permease component
F3I61_RS01080	COG0673	inositol 2-dehydrogenase activity
F3I61_RS01085	COG2731	YhcH YjgK YiaL family protein
F3I61_RS01125	COG3266	domain, Protein
F3I61_RS01125	COG2911	Protein conserved in bacteria
F3I61_RS01125	COG1361	Conserved repeat domain
F3I61_RS01165	COG0583	DNA-binding transcription factor activity
F3I61_RS01170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3I61_RS01180	COG0490	domain, Protein
F3I61_RS01180	COG0471	metal ion transport
F3I61_RS01190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F3I61_RS01195	COG3829	transcription factor binding
F3I61_RS01205	COG0686	Belongs to the AlaDH PNT family
F3I61_RS01220	COG1757	Na H antiporter
F3I61_RS01225	COG0402	S-adenosylhomocysteine deaminase activity
F3I61_RS01230	COG0534	Mate efflux family protein
F3I61_RS01250	COG1696	Membrane protein involved in D-alanine export
F3I61_RS01260	COG1874	Beta-galactosidase
F3I61_RS01270	COG1501	Belongs to the glycosyl hydrolase 31 family
F3I61_RS01280	COG3829	transcription factor binding
F3I61_RS01295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3I61_RS01300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3I61_RS01310	COG1760	l-serine dehydratase
F3I61_RS01315	COG1760	l-serine dehydratase
F3I61_RS01325	COG0095	Lipoate-protein ligase
F3I61_RS01330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3I61_RS01335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F3I61_RS01340	COG0509	glycine decarboxylation via glycine cleavage system
F3I61_RS01345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F3I61_RS01350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F3I61_RS01350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F3I61_RS01355	COG1609	Transcriptional regulator
F3I61_RS01360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3I61_RS01365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3I61_RS01370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3I61_RS01405	COG1028	Short-chain dehydrogenase reductase Sdr
F3I61_RS01410	COG0726	polysaccharide deacetylase
F3I61_RS01420	COG0583	DNA-binding transcription factor activity
F3I61_RS01440	COG4213	ABC transporter substrate-binding protein
F3I61_RS01450	COG1172	Belongs to the binding-protein-dependent transport system permease family
F3I61_RS01455	COG1070	Carbohydrate kinase
F3I61_RS01465	COG2364	Membrane
F3I61_RS01480	COG1940	carbohydrate kinase activity
F3I61_RS01510	COG2376	Dihydroxyacetone kinase
F3I61_RS01525	COG2239	Acts as a magnesium transporter
F3I61_RS01535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F3I61_RS01540	COG0561	phosphatase activity
F3I61_RS01550	COG0038	chloride channel
F3I61_RS01555	COG1328	CTP reductase activity
F3I61_RS01555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F3I61_RS01560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F3I61_RS01570	COG1595	DNA-templated transcription, initiation
F3I61_RS01575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F3I61_RS01595	COG1802	Transcriptional regulator
F3I61_RS01605	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F3I61_RS01610	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F3I61_RS01615	COG0471	metal ion transport
F3I61_RS01620	COG1349	DNA-binding transcription factor activity
F3I61_RS01665	COG0405	Gamma-glutamyltransferase
F3I61_RS01670	COG3192	ethanolamine utilization protein
F3I61_RS01675	COG1737	Transcriptional regulator
F3I61_RS01700	COG1115	amino acid carrier protein
F3I61_RS01715	COG3835	regulator
F3I61_RS01720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3I61_RS01725	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F3I61_RS01730	COG1984	allophanate hydrolase subunit 2
F3I61_RS01735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F3I61_RS01745	COG0436	Aminotransferase
F3I61_RS01750	COG0583	DNA-binding transcription factor activity
F3I61_RS01755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F3I61_RS01765	COG2188	Transcriptional regulator
F3I61_RS01775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F3I61_RS01785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F3I61_RS01785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F3I61_RS01790	COG1063	alcohol dehydrogenase
F3I61_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
F3I61_RS01810	COG2323	membrane
F3I61_RS01815	COG0662	Cupin 2, conserved barrel domain protein
F3I61_RS01820	COG0723	plastoquinol--plastocyanin reductase activity
F3I61_RS01820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3I61_RS01840	COG0519	Catalyzes the synthesis of GMP from XMP
F3I61_RS01850	COG4604	ABC transporter, ATP-binding protein
F3I61_RS01855	COG4605	iron ion homeostasis
F3I61_RS01860	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3I61_RS01875	COG1361	Conserved repeat domain
F3I61_RS01895	COG3266	domain, Protein
F3I61_RS01895	COG2911	Protein conserved in bacteria
F3I61_RS01895	COG1361	Conserved repeat domain
F3I61_RS01910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F3I61_RS01915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F3I61_RS01920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F3I61_RS01925	COG1185	polyribonucleotide nucleotidyltransferase activity
F3I61_RS01940	COG4496	protein, YerC YecD
F3I61_RS01955	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F3I61_RS01970	COG0280	phosphate acetyltransferase
F3I61_RS01980	COG0481	GTPase activity
F3I61_RS02020	COG1472	Belongs to the glycosyl hydrolase 3 family
F3I61_RS02040	COG0205	6-phosphofructokinase activity
F3I61_RS02060	COG1316	TRANSCRIPTIONal
F3I61_RS02065	COG1316	TRANSCRIPTIONal
F3I61_RS02070	COG1473	amidohydrolase
F3I61_RS02075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3I61_RS02090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3I61_RS02095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F3I61_RS02120	COG0564	pseudouridine synthase activity
F3I61_RS02125	COG2217	Heavy metal translocating P-type atpase
F3I61_RS02135	COG0640	Transcriptional regulator
F3I61_RS02160	COG1194	a g-specific adenine glycosylase
F3I61_RS02170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F3I61_RS02275	COG1686	Belongs to the peptidase S11 family
F3I61_RS02280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F3I61_RS02290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F3I61_RS02295	COG0297	glycogen (starch) synthase activity
F3I61_RS02300	COG0058	SHG alpha-glucan phosphorylase activity
F3I61_RS02305	COG0698	ribose 5-phosphate isomerase
F3I61_RS02310	COG0860	N-Acetylmuramoyl-L-alanine amidase
F3I61_RS02315	COG0745	RESPONSE REGULATOR receiver
F3I61_RS02330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F3I61_RS02385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F3I61_RS02390	COG0745	RESPONSE REGULATOR receiver
F3I61_RS02395	COG5002	protein histidine kinase activity
F3I61_RS02395	COG3850	Histidine kinase
F3I61_RS02420	COG2207	Transcriptional regulator
F3I61_RS02430	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F3I61_RS02435	COG2373	Large extracellular alpha-helical protein
F3I61_RS02445	COG0577	efflux transmembrane transporter activity
F3I61_RS02445	COG1136	(ABC) transporter
F3I61_RS02460	COG0561	phosphatase activity
F3I61_RS02465	COG1918	ferrous iron import across plasma membrane
F3I61_RS02465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F3I61_RS02515	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F3I61_RS02530	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
F3I61_RS02535	COG0534	Mate efflux family protein
F3I61_RS02550	COG1051	belongs to the nudix hydrolase family
F3I61_RS02555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F3I61_RS02560	COG0028	Belongs to the TPP enzyme family
F3I61_RS02565	COG0440	acetolactate synthase activity
F3I61_RS02570	COG0028	Belongs to the TPP enzyme family
F3I61_RS02580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F3I61_RS02590	COG2188	Transcriptional regulator
F3I61_RS02595	COG0129	dihydroxy-acid dehydratase activity
F3I61_RS02615	COG1098	S1 RNA binding domain
F3I61_RS02620	COG1228	amidohydrolase
F3I61_RS02630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F3I61_RS02630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F3I61_RS02645	COG3845	ABC transporter
F3I61_RS02650	COG4603	Belongs to the binding-protein-dependent transport system permease family
F3I61_RS02655	COG1079	Belongs to the binding-protein-dependent transport system permease family
F3I61_RS02665	COG0583	DNA-binding transcription factor activity
F3I61_RS02670	COG1288	antiporter activity
F3I61_RS02695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F3I61_RS02700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F3I61_RS02705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F3I61_RS02715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F3I61_RS02730	COG1960	acyl-CoA dehydrogenase activity
F3I61_RS02735	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3I61_RS02770	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F3I61_RS02820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3I61_RS02830	COG3426	butyrate kinase activity
F3I61_RS02835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F3I61_RS02840	COG0436	Aminotransferase
F3I61_RS02845	COG0469	pyruvate kinase activity
F3I61_RS02855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3I61_RS02905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F3I61_RS02930	COG2873	o-acetylhomoserine
F3I61_RS02945	COG0822	iron-sulfur transferase activity
F3I61_RS02950	COG1959	2 iron, 2 sulfur cluster binding
F3I61_RS02970	COG2205	protein histidine kinase activity
F3I61_RS02985	COG2205	protein histidine kinase activity
F3I61_RS02990	COG3872	metal-dependent enzyme
F3I61_RS02995	COG2890	protein-(glutamine-N5) methyltransferase activity
F3I61_RS03010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3I61_RS03015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F3I61_RS03025	COG1917	Cupin 2, conserved barrel domain protein
F3I61_RS03025	COG4977	sequence-specific DNA binding
F3I61_RS03030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F3I61_RS03035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F3I61_RS03040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F3I61_RS03045	COG1924	4 iron, 4 sulfur cluster binding
F3I61_RS03050	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
F3I61_RS03055	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
F3I61_RS03060	COG4770	biotin carboxylase activity
F3I61_RS03065	COG4770	biotin carboxylase activity
F3I61_RS03070	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F3I61_RS03080	COG1196	nuclear chromosome segregation
F3I61_RS03100	COG0552	protein localization to endoplasmic reticulum
F3I61_RS03110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F3I61_RS03120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F3I61_RS03125	COG1534	Rna-binding protein
F3I61_RS03130	COG1713	HD superfamily hydrolase involved in NAD metabolism
F3I61_RS03135	COG1316	TRANSCRIPTIONal
F3I61_RS03140	COG0799	negative regulation of ribosome biogenesis
F3I61_RS03195	COG0733	neurotransmitter:sodium symporter activity
F3I61_RS03200	COG0745	RESPONSE REGULATOR receiver
F3I61_RS03205	COG5002	protein histidine kinase activity
F3I61_RS03235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F3I61_RS03245	COG0352	thiamine-phosphate diphosphorylase activity
F3I61_RS03245	COG0351	phosphomethylpyrimidine kinase
F3I61_RS03250	COG0546	phosphoglycolate phosphatase activity
F3I61_RS03255	COG0295	cytidine deaminase activity
F3I61_RS03260	COG2155	Conserved Protein
F3I61_RS03265	COG0577	efflux transmembrane transporter activity
F3I61_RS03265	COG1136	(ABC) transporter
F3I61_RS03270	COG1136	(ABC) transporter
F3I61_RS03295	COG3852	Histidine kinase
F3I61_RS03300	COG2204	response regulator
F3I61_RS03305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F3I61_RS03310	COG1914	H( )-stimulated, divalent metal cation uptake system
F3I61_RS03315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F3I61_RS03320	COG1984	allophanate hydrolase subunit 2
F3I61_RS03325	COG4336	lyase activity
F3I61_RS03345	COG1028	Short-chain dehydrogenase reductase Sdr
F3I61_RS03360	COG1269	ATP hydrolysis coupled proton transport
F3I61_RS03365	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F3I61_RS03370	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
F3I61_RS03380	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
F3I61_RS03385	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
F3I61_RS03390	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
F3I61_RS03395	COG1394	ATPase activity, coupled to movement of substances
F3I61_RS03410	COG0363	glucosamine-6-phosphate deaminase activity
F3I61_RS03425	COG1737	Transcriptional regulator
F3I61_RS03440	COG2379	hydroxypyruvate reductase
F3I61_RS03460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F3I61_RS03465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3I61_RS03470	COG1028	Short-chain dehydrogenase reductase Sdr
F3I61_RS03475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F3I61_RS03490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F3I61_RS03500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F3I61_RS03505	COG0439	Biotin carboxylase
F3I61_RS03530	COG1151	hydroxylamine reductase activity
F3I61_RS03540	COG1609	Transcriptional regulator
F3I61_RS03545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F3I61_RS03550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F3I61_RS03555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F3I61_RS03560	COG1177	transmembrane transport
F3I61_RS03565	COG1176	ABC-type spermidine putrescine transport system, permease component I
F3I61_RS03570	COG3842	ATPase activity
F3I61_RS03575	COG0564	pseudouridine synthase activity
F3I61_RS03590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F3I61_RS03595	COG2226	methyltransferase
F3I61_RS03600	COG4496	protein, YerC YecD
F3I61_RS03610	COG1114	Component of the transport system for branched-chain amino acids
F3I61_RS03640	COG4209	transmembrane transport
F3I61_RS03645	COG0395	ABC-type sugar transport system, permease component
F3I61_RS03665	COG0583	DNA-binding transcription factor activity
F3I61_RS03675	COG1132	(ABC) transporter
F3I61_RS03680	COG1132	(ABC) transporter
F3I61_RS03690	COG1695	Transcriptional regulator
F3I61_RS03730	COG1253	flavin adenine dinucleotide binding
F3I61_RS03735	COG0540	Belongs to the ATCase OTCase family
F3I61_RS03765	COG0012	GTP binding
F3I61_RS03770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3I61_RS03775	COG0464	growth
F3I61_RS03795	COG2059	Chromate
F3I61_RS03810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F3I61_RS03815	COG0513	Belongs to the DEAD box helicase family
F3I61_RS03820	COG0427	acetyl-CoA hydrolase
F3I61_RS03835	COG0084	hydrolase, TatD family'
F3I61_RS03845	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3I61_RS03855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3I61_RS03855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3I61_RS03870	COG0482	sulfurtransferase activity
F3I61_RS03875	COG1328	CTP reductase activity
F3I61_RS03880	COG0602	queuosine metabolic process
F3I61_RS03885	COG0534	Mate efflux family protein
F3I61_RS03915	COG1115	amino acid carrier protein
F3I61_RS03920	COG0653	protein targeting
F3I61_RS03950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F3I61_RS03960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F3I61_RS03970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F3I61_RS03990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F3I61_RS03995	COG2264	protein methyltransferase activity
F3I61_RS04015	COG3191	aminopeptidase activity
F3I61_RS04025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3I61_RS04030	COG2211	Major facilitator Superfamily
F3I61_RS04035	COG1063	alcohol dehydrogenase
F3I61_RS04045	COG0574	Belongs to the PEP-utilizing enzyme family
F3I61_RS04045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F3I61_RS04060	COG1058	Belongs to the CinA family
F3I61_RS04060	COG1546	Belongs to the CinA family
F3I61_RS04065	COG0301	tRNA thio-modification
F3I61_RS04070	COG0606	chelatase, subunit chli
F3I61_RS04095	COG3655	Transcriptional regulator
F3I61_RS04125	COG1408	metallophosphoesterase
F3I61_RS04155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F3I61_RS04160	COG1381	Involved in DNA repair and RecF pathway recombination
F3I61_RS04165	COG1164	Oligoendopeptidase f
F3I61_RS04170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3I61_RS04175	COG0131	Imidazoleglycerol-phosphate dehydratase
F3I61_RS04180	COG0124	histidyl-tRNA synthetase
F3I61_RS04185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F3I61_RS04190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F3I61_RS04195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F3I61_RS04200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F3I61_RS04205	COG0107	imidazoleglycerol-phosphate synthase activity
F3I61_RS04210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F3I61_RS04240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F3I61_RS04245	COG1837	Belongs to the UPF0109 family
F3I61_RS04250	COG0228	four-way junction DNA binding
F3I61_RS04255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F3I61_RS04260	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
F3I61_RS04265	COG0612	Peptidase, M16
F3I61_RS04270	COG0612	Peptidase, M16
F3I61_RS04280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F3I61_RS04285	COG3854	ATPases associated with a variety of cellular activities
F3I61_RS04330	COG3290	protein histidine kinase activity
F3I61_RS04340	COG0786	glutamate:sodium symporter activity
F3I61_RS04350	COG1609	Transcriptional regulator
F3I61_RS04355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F3I61_RS04390	COG0519	Catalyzes the synthesis of GMP from XMP
F3I61_RS04410	COG5002	protein histidine kinase activity
F3I61_RS04425	COG3366	ferrous iron transmembrane transporter activity
F3I61_RS04430	COG0700	Nucleoside recognition
F3I61_RS04435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F3I61_RS04440	COG2814	Major facilitator Superfamily
F3I61_RS04450	COG0427	acetyl-CoA hydrolase
F3I61_RS04475	COG0167	dihydroorotate dehydrogenase activity
F3I61_RS04480	COG0543	2 iron, 2 sulfur cluster binding
F3I61_RS04495	COG0284	orotidine-5'-phosphate decarboxylase activity
F3I61_RS04500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F3I61_RS04510	COG0716	FMN binding
F3I61_RS04525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F3I61_RS04535	COG1917	Cupin 2, conserved barrel domain protein
F3I61_RS04535	COG2207	Transcriptional regulator
F3I61_RS04545	COG1175	transmembrane transport
F3I61_RS04560	COG5426	von Willebrand factor, type A
F3I61_RS04570	COG1733	regulation of RNA biosynthetic process
F3I61_RS04585	COG4221	oxidoreductase activity
F3I61_RS04595	COG0222	ribosome binding
F3I61_RS04600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F3I61_RS04605	COG0081	regulation of translation
F3I61_RS04610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F3I61_RS04615	COG0250	Participates in transcription elongation, termination and antitermination
F3I61_RS04620	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F3I61_RS04625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F3I61_RS04650	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F3I61_RS04655	COG0006	proline dipeptidase activity
F3I61_RS04660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F3I61_RS04680	COG1187	pseudouridine synthase activity
F3I61_RS04685	COG2508	Transcriptional regulator
F3I61_RS04690	COG2884	Cell division ATP-binding protein ftsE
F3I61_RS04695	COG2177	Part of the ABC transporter FtsEX involved in
F3I61_RS04700	COG1196	nuclear chromosome segregation
F3I61_RS04700	COG0741	lytic transglycosylase activity
F3I61_RS04700	COG0739	heme binding
F3I61_RS04715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F3I61_RS04720	COG1846	Transcriptional regulator
F3I61_RS04725	COG0534	Mate efflux family protein
F3I61_RS04740	COG1918	ferrous iron import across plasma membrane
F3I61_RS04740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F3I61_RS04775	COG1181	Belongs to the D-alanine--D-alanine ligase family
F3I61_RS04795	COG4988	ABC transporter
F3I61_RS04800	COG1132	(ABC) transporter
F3I61_RS04810	COG2832	Protein of unknown function (DUF454)
F3I61_RS04820	COG1737	Transcriptional regulator
F3I61_RS04825	COG3842	ATPase activity
F3I61_RS04850	COG5002	protein histidine kinase activity
F3I61_RS04855	COG0745	RESPONSE REGULATOR receiver
F3I61_RS04870	COG0484	heat shock protein binding
F3I61_RS04875	COG0443	Heat shock 70 kDa protein
F3I61_RS04885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F3I61_RS04885	COG1648	precorrin-2 dehydrogenase activity
F3I61_RS04890	COG1120	ATPase activity
F3I61_RS04895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3I61_RS04905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F3I61_RS04910	COG0583	DNA-binding transcription factor activity
F3I61_RS04915	COG0583	DNA-binding transcription factor activity
F3I61_RS04935	COG3839	Belongs to the ABC transporter superfamily
F3I61_RS04950	COG1840	ABC-type Fe3 transport system, periplasmic component
F3I61_RS04955	COG2972	Histidine kinase
F3I61_RS04960	COG2207	Transcriptional regulator
F3I61_RS04960	COG4753	response regulator
F3I61_RS04965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F3I61_RS04970	COG3022	response to hydroperoxide
F3I61_RS04985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F3I61_RS05020	COG3655	Transcriptional regulator
F3I61_RS05030	COG0137	argininosuccinate synthase activity
F3I61_RS05035	COG0165	Argininosuccinate lyase
F3I61_RS05040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F3I61_RS05045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F3I61_RS05050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F3I61_RS05095	COG3409	Peptidoglycan-binding domain 1 protein
F3I61_RS05095	COG3773	Cell wall hydrolase
F3I61_RS05105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F3I61_RS05110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F3I61_RS05115	COG1160	GTP binding
F3I61_RS05120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3I61_RS05135	COG0463	Glycosyl transferase, family 2
F3I61_RS05155	COG0668	transmembrane transport
F3I61_RS05170	COG2094	Belongs to the DNA glycosylase MPG family
F3I61_RS05180	COG0561	phosphatase activity
F3I61_RS05200	COG0367	asparagine synthase
F3I61_RS05205	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F3I61_RS05210	COG0504	CTP synthase activity
F3I61_RS05215	COG1968	undecaprenyl-diphosphatase activity
F3I61_RS05220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F3I61_RS05240	COG0494	nUDIX hydrolase
F3I61_RS05245	COG2176	DNA-directed DNA polymerase activity
F3I61_RS05265	COG4211	Belongs to the binding-protein-dependent transport system permease family
F3I61_RS05270	COG1129	ABC transporter
F3I61_RS05275	COG1879	ABC-type sugar transport system periplasmic component
F3I61_RS05285	COG2972	Histidine kinase
F3I61_RS05290	COG4753	response regulator
F3I61_RS05290	COG2207	Transcriptional regulator
F3I61_RS05305	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F3I61_RS05310	COG0402	S-adenosylhomocysteine deaminase activity
F3I61_RS05320	COG1309	transcriptional regulator
F3I61_RS05325	COG4716	Myosin-crossreactive antigen
F3I61_RS05355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F3I61_RS05375	COG0110	maltose O-acetyltransferase activity
F3I61_RS05380	COG0583	DNA-binding transcription factor activity
F3I61_RS05385	COG4187	Peptidase family M20/M25/M40
F3I61_RS05390	COG1228	amidohydrolase
F3I61_RS05400	COG1115	amino acid carrier protein
F3I61_RS05415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3I61_RS05415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3I61_RS05435	COG0420	3'-5' exonuclease activity
F3I61_RS05440	COG0419	ATPase involved in DNA repair
F3I61_RS05445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F3I61_RS05450	COG0745	RESPONSE REGULATOR receiver
F3I61_RS05460	COG1690	Belongs to the RtcB family
F3I61_RS05495	COG3620	sequence-specific DNA binding
F3I61_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
F3I61_RS05550	COG0242	peptide deformylase activity
F3I61_RS05600	COG0640	Transcriptional regulator
F3I61_RS05605	COG0701	Predicted permease
F3I61_RS05650	COG0745	RESPONSE REGULATOR receiver
F3I61_RS05655	COG2205	protein histidine kinase activity
F3I61_RS05665	COG1136	(ABC) transporter
F3I61_RS05685	COG3069	C4-dicarboxylate transmembrane transporter activity
F3I61_RS05690	COG2195	Cleaves the N-terminal amino acid of tripeptides
F3I61_RS05695	COG0281	malic enzyme
F3I61_RS05805	COG3196	Protein conserved in bacteria
F3I61_RS06040	COG0202	RNA polymerase activity
F3I61_RS06085	COG0582	viral genome integration into host DNA
F3I61_RS06090	COG0582	viral genome integration into host DNA
F3I61_RS06145	COG1401	restriction endodeoxyribonuclease activity
F3I61_RS06160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3I61_RS06205	COG0582	viral genome integration into host DNA
F3I61_RS06210	COG0582	viral genome integration into host DNA
F3I61_RS06270	COG1136	(ABC) transporter
F3I61_RS06275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F3I61_RS06290	COG0789	Transcriptional regulator
F3I61_RS06295	COG1309	transcriptional regulator
F3I61_RS06305	COG3708	Transcriptional regulator
F3I61_RS06305	COG2207	Transcriptional regulator
F3I61_RS06340	COG2378	regulation of single-species biofilm formation
F3I61_RS06345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F3I61_RS06360	COG0583	DNA-binding transcription factor activity
F3I61_RS06405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F3I61_RS06415	COG1132	(ABC) transporter
F3I61_RS06420	COG1132	(ABC) transporter
F3I61_RS06425	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
F3I61_RS06430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F3I61_RS06435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F3I61_RS06440	COG1609	Transcriptional regulator
F3I61_RS06445	COG1725	Transcriptional regulator
F3I61_RS06470	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F3I61_RS06475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3I61_RS06485	COG0336	Belongs to the RNA methyltransferase TrmD family
F3I61_RS06505	COG3773	Cell wall hydrolase
F3I61_RS06505	COG3409	Peptidoglycan-binding domain 1 protein
F3I61_RS06510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F3I61_RS06515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F3I61_RS06520	COG1570	exodeoxyribonuclease VII activity
F3I61_RS06540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F3I61_RS06545	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F3I61_RS06550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F3I61_RS06555	COG1438	arginine binding
F3I61_RS06560	COG0497	DNA recombination
F3I61_RS06570	COG0772	Belongs to the SEDS family
F3I61_RS06575	COG0802	atpase or kinase
F3I61_RS06590	COG0335	large ribosomal subunit rRNA binding
F3I61_RS06600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F3I61_RS06605	COG0792	nuclease activity
F3I61_RS06610	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F3I61_RS06620	COG0544	peptidyl-prolyl cis-trans isomerase activity
F3I61_RS06635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F3I61_RS06640	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F3I61_RS06645	COG1994	Peptidase M50
F3I61_RS06650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F3I61_RS06655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F3I61_RS06665	COG3874	Sporulation protein YtfJ
F3I61_RS06670	COG1686	Belongs to the peptidase S11 family
F3I61_RS06675	COG1187	pseudouridine synthase activity
F3I61_RS06680	COG1737	Transcriptional regulator
F3I61_RS06685	COG2081	HI0933 family
F3I61_RS06690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F3I61_RS06700	COG0539	negative regulation of cytoplasmic translation
F3I61_RS06700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F3I61_RS06710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F3I61_RS06715	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F3I61_RS06725	COG1104	cysteine desulfurase activity
F3I61_RS06735	COG0670	Belongs to the BI1 family
F3I61_RS06740	COG0659	secondary active sulfate transmembrane transporter activity
F3I61_RS06755	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F3I61_RS06765	COG0632	four-way junction helicase activity
F3I61_RS06775	COG2255	four-way junction helicase activity
F3I61_RS06815	COG2384	SAM-dependent methyltransferase
F3I61_RS06820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F3I61_RS06830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F3I61_RS06835	COG0488	(ABC) transporter
F3I61_RS06845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F3I61_RS06855	COG0546	phosphoglycolate phosphatase activity
F3I61_RS06860	COG0009	L-threonylcarbamoyladenylate synthase
F3I61_RS06865	COG3620	sequence-specific DNA binding
F3I61_RS06875	COG1362	aminopeptidase activity
F3I61_RS06885	COG0740	serine-type endopeptidase activity
F3I61_RS06895	COG0628	permease
F3I61_RS06900	COG0205	6-phosphofructokinase activity
F3I61_RS06905	COG0191	fructose-bisphosphate aldolase activity
F3I61_RS06915	COG1797	cobyrinic acid a,c-diamide synthase activity
F3I61_RS06920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F3I61_RS06930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F3I61_RS06945	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F3I61_RS06950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F3I61_RS06955	COG1492	cobalamin metabolic process
F3I61_RS06965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F3I61_RS06975	COG1388	LysM domain
F3I61_RS06975	COG3858	chitin binding
F3I61_RS06995	COG0739	heme binding
F3I61_RS07010	COG1120	ATPase activity
F3I61_RS07030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F3I61_RS07030	COG2080	2 iron, 2 sulfur cluster binding
F3I61_RS07035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F3I61_RS07040	COG0318	PFAM AMP-dependent synthetase and ligase
F3I61_RS07045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3I61_RS07075	COG1476	TRANSCRIPTIONal
F3I61_RS07080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3I61_RS07085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F3I61_RS07090	COG0066	3-isopropylmalate dehydratase activity
F3I61_RS07095	COG0473	3-isopropylmalate dehydrogenase activity
F3I61_RS07110	COG0426	domain, Protein
F3I61_RS07120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F3I61_RS07125	COG1120	ATPase activity
F3I61_RS07130	COG1088	dTDP-glucose 4,6-dehydratase activity
F3I61_RS07145	COG0134	indole-3-glycerol-phosphate synthase activity
F3I61_RS07155	COG0133	tryptophan synthase activity
F3I61_RS07160	COG0159	tryptophan synthase activity
F3I61_RS07165	COG1028	Short-chain dehydrogenase reductase Sdr
F3I61_RS07175	COG3620	sequence-specific DNA binding
F3I61_RS07190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3I61_RS07205	COG3959	Transketolase, thiamine diphosphate binding domain
F3I61_RS07210	COG3958	Transketolase
F3I61_RS07245	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F3I61_RS07260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F3I61_RS07265	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F3I61_RS07270	COG1285	pathogenesis
F3I61_RS07280	COG0295	cytidine deaminase activity
F3I61_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
F3I61_RS07365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F3I61_RS07390	COG1595	DNA-templated transcription, initiation
F3I61_RS07435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3I61_RS07435	COG0723	plastoquinol--plastocyanin reductase activity
F3I61_RS07455	COG0582	viral genome integration into host DNA
F3I61_RS07460	COG0519	Catalyzes the synthesis of GMP from XMP
F3I61_RS07475	COG1196	nuclear chromosome segregation
F3I61_RS07475	COG0739	heme binding
F3I61_RS07475	COG0741	lytic transglycosylase activity
F3I61_RS07495	COG0217	transcriptional regulatory protein
F3I61_RS07515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F3I61_RS07535	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
F3I61_RS07560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F3I61_RS07565	COG4974	Belongs to the 'phage' integrase family
F3I61_RS07575	COG1695	Transcriptional regulator
F3I61_RS07615	COG3546	catalase activity
F3I61_RS07655	COG3608	succinylglutamate desuccinylase aspartoacylase
F3I61_RS07655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F3I61_RS07660	COG0709	Synthesizes selenophosphate from selenide and ATP
F3I61_RS07665	COG3608	succinylglutamate desuccinylase aspartoacylase
F3I61_RS07665	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F3I61_RS07675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3I61_RS07680	COG0425	Belongs to the sulfur carrier protein TusA family
F3I61_RS07680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3I61_RS07685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3I61_RS07695	COG0583	DNA-binding transcription factor activity
F3I61_RS07700	COG1473	amidohydrolase
F3I61_RS07705	COG3273	potassium ion transport
F3I61_RS07705	COG0471	metal ion transport
F3I61_RS07710	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F3I61_RS07715	COG3681	Belongs to the UPF0597 family
F3I61_RS07725	COG2205	protein histidine kinase activity
F3I61_RS07760	COG4974	Belongs to the 'phage' integrase family
F3I61_RS07785	COG1862	Preprotein translocase
F3I61_RS07800	COG2385	sporulation resulting in formation of a cellular spore
F3I61_RS07810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3I61_RS07815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F3I61_RS07820	COG2033	superoxide reductase activity
F3I61_RS07825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F3I61_RS07835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F3I61_RS07845	COG0281	malic enzyme
F3I61_RS07850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F3I61_RS07860	COG1162	GTPase activity
F3I61_RS07865	COG2815	serine threonine protein kinase
F3I61_RS07865	COG0515	serine threonine protein kinase
F3I61_RS07870	COG0631	protein serine/threonine phosphatase activity
F3I61_RS07875	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F3I61_RS07885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F3I61_RS07890	COG0242	peptide deformylase activity
F3I61_RS07895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F3I61_RS07900	COG1758	RNA polymerase activity
F3I61_RS07905	COG0194	GDP metabolic process
F3I61_RS07910	COG2052	Domain of unknown function (DUF370)
F3I61_RS07915	COG1561	YicC-like family, N-terminal region
F3I61_RS07925	COG0484	heat shock protein binding
F3I61_RS07945	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F3I61_RS07950	COG2033	superoxide reductase activity
F3I61_RS07955	COG1368	sulfuric ester hydrolase activity
F3I61_RS07980	COG4589	Belongs to the CDS family
F3I61_RS07990	COG0233	cytoplasmic translational termination
F3I61_RS07995	COG0528	UMP kinase activity
F3I61_RS08005	COG1966	Carbon starvation protein
F3I61_RS08010	COG1191	sigma factor activity
F3I61_RS08015	COG0651	ATP synthesis coupled electron transport
F3I61_RS08020	COG0651	ATP synthesis coupled electron transport
F3I61_RS08025	COG0651	ATP synthesis coupled electron transport
F3I61_RS08030	COG1007	ATP synthesis coupled electron transport
F3I61_RS08035	COG1006	Multisubunit Na H antiporter MnhC subunit
F3I61_RS08065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F3I61_RS08070	COG4481	Protein conserved in bacteria
F3I61_RS08075	COG0745	RESPONSE REGULATOR receiver
F3I61_RS08080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F3I61_RS08090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F3I61_RS08095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F3I61_RS08105	COG0577	efflux transmembrane transporter activity
F3I61_RS08105	COG1136	(ABC) transporter
F3I61_RS08110	COG0577	efflux transmembrane transporter activity
F3I61_RS08110	COG1136	(ABC) transporter
F3I61_RS08120	COG2226	methyltransferase
F3I61_RS08140	COG2205	protein histidine kinase activity
F3I61_RS08160	COG1902	pentaerythritol trinitrate reductase activity
F3I61_RS08195	COG1012	belongs to the aldehyde dehydrogenase family
F3I61_RS08200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F3I61_RS08210	COG0358	DNA primase activity
F3I61_RS08215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F3I61_RS08220	COG1595	DNA-templated transcription, initiation
F3I61_RS08240	COG1739	Uncharacterized protein family UPF0029
F3I61_RS08250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F3I61_RS08260	COG0254	rRNA binding
F3I61_RS08265	COG1074	ATP-dependent DNA helicase activity
F3I61_RS08290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3I61_RS08295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F3I61_RS08325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F3I61_RS08350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F3I61_RS08355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F3I61_RS08375	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F3I61_RS08380	COG1191	sigma factor activity
F3I61_RS08405	COG3976	FMN-binding domain protein
F3I61_RS08405	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
F3I61_RS08485	COG3778	Protein conserved in bacteria
F3I61_RS08490	COG3299	homolog of phage Mu protein gp47
F3I61_RS08560	COG0740	serine-type endopeptidase activity
F3I61_RS08645	COG0305	Participates in initiation and elongation during chromosome replication
F3I61_RS08655	COG2002	toxin-antitoxin pair type II binding
F3I61_RS08705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F3I61_RS08710	COG0583	DNA-binding transcription factor activity
F3I61_RS08720	COG0697	spore germination
F3I61_RS08725	COG0697	spore germination
F3I61_RS08730	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F3I61_RS08730	COG0493	'glutamate synthase
F3I61_RS08745	COG0252	asparaginase activity
F3I61_RS08755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F3I61_RS08765	COG1595	DNA-templated transcription, initiation
F3I61_RS08780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F3I61_RS08785	COG0742	ribosomal rna small subunit methyltransferase
F3I61_RS08790	COG0322	excinuclease ABC activity
F3I61_RS08795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F3I61_RS08800	COG1193	negative regulation of DNA recombination
F3I61_RS08825	COG0534	Mate efflux family protein
F3I61_RS08840	COG3711	transcriptional antiterminator
F3I61_RS08845	COG1263	PTS System
F3I61_RS08845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F3I61_RS08845	COG2190	(PTS) system
F3I61_RS08855	COG1307	EDD domain protein, DegV family
F3I61_RS08860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F3I61_RS08865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F3I61_RS08870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F3I61_RS08875	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F3I61_RS08880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F3I61_RS08890	COG0356	it plays a direct role in the translocation of protons across the membrane
F3I61_RS08895	COG3290	protein histidine kinase activity
F3I61_RS08900	COG4565	transcriptional regulatory protein
F3I61_RS08910	COG2843	Capsule synthesis protein
F3I61_RS08915	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
F3I61_RS08915	COG2878	Part of a membrane complex involved in electron transport
F3I61_RS08920	COG4657	Part of a membrane complex involved in electron transport
F3I61_RS08925	COG4660	Part of a membrane complex involved in electron transport
F3I61_RS08935	COG4658	electron transport chain
F3I61_RS08940	COG4656	Part of a membrane complex involved in electron transport
F3I61_RS08950	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
F3I61_RS08955	COG1687	branched-chain amino acid
F3I61_RS08970	COG1481	regulation of sporulation
F3I61_RS08980	COG1660	Displays ATPase and GTPase activities
F3I61_RS08995	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F3I61_RS09000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F3I61_RS09005	COG0583	DNA-binding transcription factor activity
F3I61_RS09010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F3I61_RS09015	COG0628	permease
F3I61_RS09020	COG0571	ribonuclease III activity
F3I61_RS09025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F3I61_RS09030	COG0416	fatty acid biosynthetic process
F3I61_RS09035	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F3I61_RS09040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F3I61_RS09045	COG0758	DNA mediated transformation
F3I61_RS09055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3I61_RS09060	COG0569	domain protein
F3I61_RS09065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F3I61_RS09080	COG0745	RESPONSE REGULATOR receiver
F3I61_RS09095	COG0581	inorganic phosphate transmembrane transporter activity
F3I61_RS09100	COG0573	inorganic phosphate transmembrane transporter activity
F3I61_RS09105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F3I61_RS09110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F3I61_RS09120	COG0785	Cytochrome C biogenesis protein
F3I61_RS09125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F3I61_RS09130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F3I61_RS09135	COG0793	Belongs to the peptidase S41A family
F3I61_RS09140	COG0523	cobalamin synthesis protein
F3I61_RS09150	COG3959	Transketolase, thiamine diphosphate binding domain
F3I61_RS09155	COG3958	Transketolase
F3I61_RS09205	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F3I61_RS09230	COG1116	anion transmembrane transporter activity
F3I61_RS09235	COG1115	amino acid carrier protein
F3I61_RS09240	COG0525	valine-tRNA ligase activity
F3I61_RS09245	COG0667	Aldo Keto reductase
F3I61_RS09250	COG0584	glycerophosphoryl diester phosphodiesterase
F3I61_RS09260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F3I61_RS09265	COG1979	alcohol dehydrogenase
F3I61_RS09290	COG0196	riboflavin kinase activity
F3I61_RS09295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F3I61_RS09310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F3I61_RS09320	COG2740	Nucleic-acid-binding protein implicated in transcription termination
F3I61_RS09325	COG0195	Participates in both transcription termination and antitermination
F3I61_RS09330	COG0779	Required for maturation of 30S ribosomal subunits
F3I61_RS09335	COG1122	ATPase activity
F3I61_RS09340	COG4120	Belongs to the binding-protein-dependent transport system permease family
F3I61_RS09355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F3I61_RS09360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F3I61_RS09365	COG0049	tRNA binding
F3I61_RS09370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F3I61_RS09375	COG1358	cellular component organization or biogenesis
F3I61_RS09380	COG1141	Ferredoxin
F3I61_RS09405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F3I61_RS09410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3I61_RS09415	COG0187	DNA topoisomerase II activity
F3I61_RS09425	COG2217	Heavy metal translocating P-type atpase
F3I61_RS09430	COG1937	Protein conserved in bacteria
F3I61_RS09440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F3I61_RS09440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F3I61_RS09440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F3I61_RS09445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F3I61_RS09455	COG0700	Nucleoside recognition
F3I61_RS09465	COG2002	toxin-antitoxin pair type II binding
F3I61_RS09470	COG0733	neurotransmitter:sodium symporter activity
F3I61_RS09510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F3I61_RS09520	COG0803	Belongs to the bacterial solute-binding protein 9 family
F3I61_RS09550	COG0728	peptidoglycan biosynthetic process
F3I61_RS09560	COG0671	phosphoesterase, PA-phosphatase related
F3I61_RS09575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F3I61_RS09580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F3I61_RS09585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F3I61_RS09590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F3I61_RS09605	COG0138	bifunctional purine biosynthesis protein purh
F3I61_RS09610	COG0151	Belongs to the GarS family
F3I61_RS09615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F3I61_RS09620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3I61_RS09625	COG0583	DNA-binding transcription factor activity
F3I61_RS09665	COG0205	6-phosphofructokinase activity
F3I61_RS09670	COG0517	IMP dehydrogenase activity
F3I61_RS09670	COG0516	GMP reductase activity
F3I61_RS09705	COG1063	alcohol dehydrogenase
F3I61_RS09710	COG0210	DNA helicase
F3I61_RS09730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F3I61_RS09750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F3I61_RS09755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F3I61_RS09760	COG0085	RNA polymerase activity
F3I61_RS09765	COG2731	YhcH YjgK YiaL family protein
F3I61_RS09770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3I61_RS09775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F3I61_RS09785	COG0426	domain, Protein
F3I61_RS09790	COG1215	transferase activity, transferring glycosyl groups
F3I61_RS09800	COG1174	glycine betaine transport
F3I61_RS09830	COG1876	peptidase activity
F3I61_RS09840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F3I61_RS09845	COG0495	leucyl-tRNA aminoacylation
F3I61_RS09855	COG0733	neurotransmitter:sodium symporter activity
F3I61_RS09865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F3I61_RS09870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F3I61_RS09885	COG1323	Belongs to the UPF0348 family
F3I61_RS09895	COG1288	antiporter activity
F3I61_RS09900	COG1473	amidohydrolase
F3I61_RS09905	COG1114	Component of the transport system for branched-chain amino acids
F3I61_RS09910	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F3I61_RS09915	COG3829	transcription factor binding
F3I61_RS09920	COG0071	Belongs to the small heat shock protein (HSP20) family
F3I61_RS09925	COG1683	Conserved Protein
F3I61_RS09930	COG4472	Bacterial protein of unknown function (DUF965)
F3I61_RS09935	COG3620	sequence-specific DNA binding
F3I61_RS09945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F3I61_RS09945	COG0519	Catalyzes the synthesis of GMP from XMP
F3I61_RS09960	COG2323	membrane
F3I61_RS09970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3I61_RS09975	COG0110	maltose O-acetyltransferase activity
F3I61_RS09980	COG0436	Aminotransferase
F3I61_RS09985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F3I61_RS10000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F3I61_RS10005	COG1115	amino acid carrier protein
F3I61_RS10015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F3I61_RS10020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3I61_RS10025	COG0765	amino acid transport
F3I61_RS10035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F3I61_RS10040	COG1592	Rubrerythrin
F3I61_RS10045	COG0215	cysteine-tRNA ligase activity
F3I61_RS10050	COG1045	serine acetyltransferase
F3I61_RS10055	COG3620	sequence-specific DNA binding
F3I61_RS10065	COG0537	adenosine 5'-monophosphoramidase activity
F3I61_RS10075	COG1191	sigma factor activity
F3I61_RS10085	COG1191	sigma factor activity
F3I61_RS10090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F3I61_RS10120	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
F3I61_RS10120	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
F3I61_RS10130	COG3051	citrate lyase alpha subunit
F3I61_RS10140	COG3052	prosthetic group binding
F3I61_RS10145	COG0583	DNA-binding transcription factor activity
F3I61_RS10150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F3I61_RS10155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F3I61_RS10160	COG0494	nUDIX hydrolase
F3I61_RS10170	COG0018	arginyl-trna synthetase
F3I61_RS10190	COG1785	Belongs to the alkaline phosphatase family
F3I61_RS10195	COG1959	2 iron, 2 sulfur cluster binding
F3I61_RS10200	COG0437	4 iron, 4 sulfur cluster binding
F3I61_RS10205	COG1388	LysM domain
F3I61_RS10205	COG0791	NLP P60 protein
F3I61_RS10215	COG1368	sulfuric ester hydrolase activity
F3I61_RS10225	COG0052	Belongs to the universal ribosomal protein uS2 family
F3I61_RS10230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F3I61_RS10240	COG3507	Belongs to the glycosyl hydrolase 43 family
F3I61_RS10255	COG3875	lactate racemase activity
F3I61_RS10265	COG2244	polysaccharide biosynthetic process
F3I61_RS10270	COG1024	Enoyl-CoA hydratase
F3I61_RS10285	COG2720	vancomycin resistance protein
F3I61_RS10305	COG1966	Carbon starvation protein
F3I61_RS10320	COG3118	belongs to the thioredoxin family
F3I61_RS10325	COG0492	ferredoxin-NADP+ reductase activity
F3I61_RS10335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F3I61_RS10345	COG1595	DNA-templated transcription, initiation
F3I61_RS10350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F3I61_RS10380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F3I61_RS10385	COG0556	nucleotide-excision repair
F3I61_RS10390	COG2003	Belongs to the UPF0758 family
F3I61_RS10395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F3I61_RS10400	COG2205	protein histidine kinase activity
F3I61_RS10435	COG2337	Toxic component of a toxin-antitoxin (TA) module
F3I61_RS10450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F3I61_RS10450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F3I61_RS10455	COG0719	Fe-S assembly protein
F3I61_RS10460	COG1137	ATPase activity
F3I61_RS10465	COG1649	PFAM Uncharacterised BCR, COG1649
F3I61_RS10465	COG0726	polysaccharide deacetylase
F3I61_RS10470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F3I61_RS10475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3I61_RS10475	COG0072	phenylalanine-tRNA ligase activity
F3I61_RS10490	COG1410	methionine synthase
F3I61_RS10490	COG0646	methionine synthase
F3I61_RS10500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F3I61_RS10505	COG0405	Gamma-glutamyltransferase
F3I61_RS10515	COG0708	Exodeoxyribonuclease III
F3I61_RS10520	COG2502	aspartate--ammonia ligase
F3I61_RS10535	COG1592	Rubrerythrin
F3I61_RS10535	COG1773	rubredoxin
F3I61_RS10540	COG1773	rubredoxin
F3I61_RS10555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F3I61_RS10570	COG0428	transporter
F3I61_RS10575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F3I61_RS10580	COG3457	Alanine racemase
F3I61_RS10585	COG1757	Na H antiporter
F3I61_RS10590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F3I61_RS10595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F3I61_RS10600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F3I61_RS10605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F3I61_RS10610	COG0583	DNA-binding transcription factor activity
F3I61_RS10620	COG1040	competence protein
F3I61_RS10630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F3I61_RS10635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F3I61_RS10640	COG1346	cytolysis
F3I61_RS10645	COG1380	Effector of murein hydrolase LrgA
F3I61_RS10655	COG2233	PERMEase
F3I61_RS10665	COG1442	glycosyl transferase family 8
F3I61_RS10690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F3I61_RS10700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3I61_RS10705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F3I61_RS10710	COG0772	Belongs to the SEDS family
F3I61_RS10715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F3I61_RS10720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3I61_RS10725	COG0768	penicillin binding
F3I61_RS10735	COG0275	rRNA processing
F3I61_RS10740	COG2001	Belongs to the MraZ family
F3I61_RS10745	COG1573	uracil-dna glycosylase
F3I61_RS10750	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
F3I61_RS10760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F3I61_RS10765	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F3I61_RS10775	COG0235	Class ii aldolase
F3I61_RS10780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F3I61_RS10785	COG2017	converts alpha-aldose to the beta-anomer
F3I61_RS10790	COG1686	Belongs to the peptidase S11 family
F3I61_RS10795	COG1555	photosystem II stabilization
F3I61_RS10805	COG2205	protein histidine kinase activity
F3I61_RS10815	COG2873	o-acetylhomoserine
F3I61_RS10830	COG0534	Mate efflux family protein
F3I61_RS10840	COG0542	response to heat
F3I61_RS10845	COG2768	binding domain, Protein
F3I61_RS10850	COG2002	toxin-antitoxin pair type II binding
F3I61_RS10890	COG4886	Leucine-rich repeat (LRR) protein
F3I61_RS10900	COG2002	toxin-antitoxin pair type II binding
F3I61_RS10905	COG1297	OPT oligopeptide transporter protein
F3I61_RS10920	COG2195	Cleaves the N-terminal amino acid of tripeptides
F3I61_RS10930	COG2207	Transcriptional regulator
F3I61_RS10940	COG0395	ABC-type sugar transport system, permease component
F3I61_RS10945	COG1175	transmembrane transport
F3I61_RS10965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F3I61_RS10975	COG1609	Transcriptional regulator
F3I61_RS10995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F3I61_RS11000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3I61_RS11015	COG1268	BioY protein
F3I61_RS11040	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F3I61_RS11045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3I61_RS11065	COG2183	response to ionizing radiation
F3I61_RS11080	COG0483	inositol monophosphate 1-phosphatase activity
F3I61_RS11090	COG0366	Alpha amylase catalytic
F3I61_RS11100	COG0750	zinc metalloprotease
F3I61_RS11105	COG0745	RESPONSE REGULATOR receiver
F3I61_RS11115	COG0534	Mate efflux family protein
F3I61_RS11120	COG1725	Transcriptional regulator
F3I61_RS11125	COG1131	(ABC) transporter
F3I61_RS11140	COG1757	Na H antiporter
F3I61_RS11200	COG0460	homoserine dehydrogenase
F3I61_RS11205	COG4492	Belongs to the UPF0735 family
F3I61_RS11210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F3I61_RS11215	COG3906	Belongs to the UPF0473 family
F3I61_RS11230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F3I61_RS11235	COG0617	tRNA 3'-terminal CCA addition
F3I61_RS11240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F3I61_RS11250	COG0126	phosphoglycerate kinase activity
F3I61_RS11255	COG0149	triose-phosphate isomerase activity
F3I61_RS11260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F3I61_RS11265	COG0148	phosphopyruvate hydratase activity
F3I61_RS11280	COG3681	Belongs to the UPF0597 family
F3I61_RS11315	COG0745	RESPONSE REGULATOR receiver
F3I61_RS11325	COG3850	Histidine kinase
F3I61_RS11325	COG5002	protein histidine kinase activity
F3I61_RS11330	COG2827	Endonuclease containing a URI domain
F3I61_RS11340	COG0569	domain protein
F3I61_RS11345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F3I61_RS11350	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F3I61_RS11365	COG0039	L-malate dehydrogenase activity
F3I61_RS11425	COG0116	Belongs to the methyltransferase superfamily
F3I61_RS11425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F3I61_RS11430	COG1122	ATPase activity
F3I61_RS11440	COG1122	ATPase activity
F3I61_RS11445	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F3I61_RS11450	COG0101	tRNA pseudouridine synthase activity
F3I61_RS11465	COG0542	response to heat
F3I61_RS11485	COG0306	phosphate transporter
F3I61_RS11490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F3I61_RS11510	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F3I61_RS11515	COG0786	glutamate:sodium symporter activity
F3I61_RS11520	COG0784	Response regulator, receiver
F3I61_RS11525	COG0745	RESPONSE REGULATOR receiver
F3I61_RS11525	COG2205	protein histidine kinase activity
F3I61_RS11525	COG4191	Histidine kinase
F3I61_RS11530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F3I61_RS11535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F3I61_RS11540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F3I61_RS11550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F3I61_RS11555	COG1737	Transcriptional regulator
F3I61_RS11560	COG0436	Aminotransferase
F3I61_RS11565	COG1301	dicarboxylic acid transport
F3I61_RS11575	COG0456	acetyltransferase
F3I61_RS11585	COG0826	peptidase U32
F3I61_RS11590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F3I61_RS11595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F3I61_RS11600	COG0693	protein deglycase activity
F3I61_RS11610	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F3I61_RS11615	COG0469	pyruvate kinase activity
F3I61_RS11620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F3I61_RS11625	COG2340	Cysteine-rich secretory protein family
F3I61_RS11630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3I61_RS11630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3I61_RS11645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F3I61_RS11660	COG0436	Aminotransferase
F3I61_RS11665	COG1522	sequence-specific DNA binding
F3I61_RS11675	COG2358	TRAP transporter, solute receptor (TAXI family
F3I61_RS11700	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F3I61_RS11705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F3I61_RS11735	COG4536	flavin adenine dinucleotide binding
F3I61_RS11750	COG0598	Magnesium transport protein CorA
F3I61_RS11755	COG2848	UPF0210 protein
F3I61_RS11760	COG3830	Belongs to the UPF0237 family
F3I61_RS11765	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F3I61_RS11780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3I61_RS11785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F3I61_RS11795	COG0037	tRNA processing
F3I61_RS11800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F3I61_RS11810	COG2986	histidine ammonia-lyase
F3I61_RS11820	COG1757	Na H antiporter
F3I61_RS11825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F3I61_RS11830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F3I61_RS11835	COG1522	sequence-specific DNA binding
F3I61_RS11840	COG1228	amidohydrolase
F3I61_RS11845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F3I61_RS11850	COG0583	DNA-binding transcription factor activity
F3I61_RS11860	COG3404	Formiminotransferase-cyclodeaminase
F3I61_RS11885	COG3842	ATPase activity
F3I61_RS11890	COG1175	transmembrane transport
F3I61_RS11895	COG0395	ABC-type sugar transport system, permease component
F3I61_RS11930	COG3842	ATPase activity
F3I61_RS11940	COG2409	Drug exporters of the RND superfamily
F3I61_RS11975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F3I61_RS11980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F3I61_RS11990	COG0534	Mate efflux family protein
F3I61_RS12030	COG0484	heat shock protein binding
F3I61_RS12035	COG0443	Heat shock 70 kDa protein
F3I61_RS12040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F3I61_RS12045	COG1420	regulation of RNA biosynthetic process
F3I61_RS12050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F3I61_RS12055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3I61_RS12060	COG0077	Prephenate dehydratase
F3I61_RS12060	COG1605	Chorismate mutase
F3I61_RS12065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F3I61_RS12070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F3I61_RS12085	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F3I61_RS12090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3I61_RS12095	COG0628	permease
F3I61_RS12100	COG1307	EDD domain protein, DegV family
F3I61_RS12105	COG4224	UPF0291 protein
F3I61_RS12125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F3I61_RS12130	COG0776	regulation of translation
F3I61_RS12135	COG3956	TIGRFAM MazG family protein
F3I61_RS12140	COG2244	polysaccharide biosynthetic process
F3I61_RS12145	COG0402	S-adenosylhomocysteine deaminase activity
F3I61_RS12160	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F3I61_RS12170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F3I61_RS12175	COG2239	Acts as a magnesium transporter
F3I61_RS12185	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F3I61_RS12190	COG0826	peptidase U32
F3I61_RS12200	COG0424	maF-like protein
F3I61_RS12215	COG0768	penicillin binding
F3I61_RS12230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F3I61_RS12260	COG3620	sequence-specific DNA binding
F3I61_RS12265	COG0789	Transcriptional regulator
F3I61_RS12280	COG0393	Putative heavy-metal-binding
F3I61_RS12285	COG1418	mRNA catabolic process
F3I61_RS12290	COG0488	(ABC) transporter
F3I61_RS12295	COG1283	sodium-dependent phosphate transmembrane transporter activity
F3I61_RS12305	COG1595	DNA-templated transcription, initiation
F3I61_RS12310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F3I61_RS12315	COG0583	DNA-binding transcription factor activity
F3I61_RS12325	COG0726	polysaccharide deacetylase
F3I61_RS12340	COG0116	Belongs to the methyltransferase superfamily
F3I61_RS12345	COG1597	lipid kinase activity
F3I61_RS12355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F3I61_RS12360	COG0459	protein refolding
F3I61_RS12375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F3I61_RS12390	COG5002	protein histidine kinase activity
F3I61_RS12395	COG0745	RESPONSE REGULATOR receiver
F3I61_RS12405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F3I61_RS12415	COG0359	binds to the 23S rRNA
F3I61_RS12420	COG0305	Participates in initiation and elongation during chromosome replication
F3I61_RS12425	COG0037	tRNA processing
F3I61_RS12430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F3I61_RS12455	COG1131	(ABC) transporter
F3I61_RS12460	COG1470	cell adhesion involved in biofilm formation
F3I61_RS12465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F3I61_RS12470	COG2188	Transcriptional regulator
F3I61_RS12475	COG1131	(ABC) transporter
F3I61_RS12505	COG1191	sigma factor activity
F3I61_RS12510	COG3870	Protein conserved in bacteria
F3I61_RS12515	COG1971	Probably functions as a manganese efflux pump
F3I61_RS12520	COG1132	(ABC) transporter
F3I61_RS12525	COG1132	(ABC) transporter
F3I61_RS12535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F3I61_RS12540	COG2302	S4 RNA-binding domain
F3I61_RS12550	COG0572	uridine kinase
F3I61_RS12555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F3I61_RS12560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F3I61_RS12575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F3I61_RS12580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F3I61_RS12580	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F3I61_RS12585	COG0445	tRNA wobble uridine modification
F3I61_RS12610	COG1876	peptidase activity
F3I61_RS12615	COG1461	Dihydroxyacetone kinase
F3I61_RS12630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F3I61_RS12660	COG0017	Asparaginyl-tRNA synthetase
F3I61_RS12715	COG0745	RESPONSE REGULATOR receiver
F3I61_RS12720	COG2205	protein histidine kinase activity
F3I61_RS12790	COG1484	DNA-dependent DNA replication
F3I61_RS12840	COG0791	NLP P60 protein
F3I61_RS12840	COG1388	LysM domain
F3I61_RS12860	COG0551	DNA topoisomerase type I activity
F3I61_RS12860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F3I61_RS12890	COG3843	relaxase mobilization nuclease domain protein
F3I61_RS12970	COG0352	thiamine-phosphate diphosphorylase activity
F3I61_RS12990	COG3859	Proton-coupled thiamine transporter YuaJ
F3I61_RS13015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F3I61_RS13025	COG2385	sporulation resulting in formation of a cellular spore
F3I61_RS13030	COG1692	metallophosphoesterase
F3I61_RS13035	COG0420	3'-5' exonuclease activity
F3I61_RS13045	COG0681	Belongs to the peptidase S26 family
F3I61_RS13050	COG0251	oxidation-reduction process
F3I61_RS13055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F3I61_RS13065	COG0202	RNA polymerase activity
F3I61_RS13070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F3I61_RS13080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F3I61_RS13090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F3I61_RS13105	COG0563	adenylate kinase activity
F3I61_RS13115	COG0200	Binds to the 23S rRNA
F3I61_RS13120	COG1841	ribosomal large subunit assembly
F3I61_RS13125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F3I61_RS13135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F3I61_RS13140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F3I61_RS13145	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F3I61_RS13155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F3I61_RS13160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F3I61_RS13165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F3I61_RS13170	COG0255	Belongs to the universal ribosomal protein uL29 family
F3I61_RS13175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F3I61_RS13180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F3I61_RS13185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F3I61_RS13190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F3I61_RS13195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F3I61_RS13200	COG0089	rRNA binding
F3I61_RS13205	COG0088	Forms part of the polypeptide exit tunnel
F3I61_RS13210	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F3I61_RS13215	COG0051	transcription antitermination factor activity, RNA binding
F3I61_RS13225	COG1827	regulation of RNA biosynthetic process
F3I61_RS13235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F3I61_RS13240	COG1115	amino acid carrier protein
F3I61_RS13250	COG5002	protein histidine kinase activity
F3I61_RS13255	COG0534	Mate efflux family protein
F3I61_RS13265	COG1136	(ABC) transporter
F3I61_RS13275	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F3I61_RS13280	COG0268	Binds directly to 16S ribosomal RNA
F3I61_RS13285	COG1295	ribonuclease BN
F3I61_RS13310	COG0612	Peptidase, M16
F3I61_RS13325	COG1720	tRNA m6t6A37 methyltransferase activity
F3I61_RS13330	COG0745	RESPONSE REGULATOR receiver
F3I61_RS13335	COG5002	protein histidine kinase activity
F3I61_RS13340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F3I61_RS13360	COG0010	Belongs to the arginase family
F3I61_RS13365	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F3I61_RS13370	COG1982	Orn Lys Arg decarboxylase major
F3I61_RS13390	COG0534	Mate efflux family protein
F3I61_RS13405	COG1131	(ABC) transporter
F3I61_RS13420	COG0745	RESPONSE REGULATOR receiver
F3I61_RS13425	COG2205	protein histidine kinase activity
F3I61_RS13440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F3I61_RS13515	COG0697	spore germination
F3I61_RS13525	COG0590	tRNA wobble adenosine to inosine editing
F3I61_RS13550	COG0730	response to heat
F3I61_RS13560	COG0183	Belongs to the thiolase family
F3I61_RS13570	COG1131	(ABC) transporter
F3I61_RS13575	COG1725	Transcriptional regulator
F3I61_RS13580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F3I61_RS13585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F3I61_RS13590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F3I61_RS13605	COG0193	aminoacyl-tRNA hydrolase activity
F3I61_RS13650	COG0166	Belongs to the GPI family
F3I61_RS13665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F3I61_RS13670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F3I61_RS13680	COG1079	Belongs to the binding-protein-dependent transport system permease family
F3I61_RS13685	COG4603	Belongs to the binding-protein-dependent transport system permease family
F3I61_RS13690	COG3845	ABC transporter
F3I61_RS13700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F3I61_RS13705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F3I61_RS13715	COG0360	Binds together with S18 to 16S ribosomal RNA
F3I61_RS13720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F3I61_RS13725	COG1595	DNA-templated transcription, initiation
F3I61_RS13730	COG3693	PFAM glycoside hydrolase, family 10
F3I61_RS13755	COG1136	(ABC) transporter
F3I61_RS13765	COG2911	Protein conserved in bacteria
F3I61_RS13765	COG3266	domain, Protein
F3I61_RS13765	COG1361	Conserved repeat domain
F3I61_RS13770	COG1301	dicarboxylic acid transport
F3I61_RS13780	COG1192	Involved in chromosome partitioning
F3I61_RS13785	COG1475	DNA binding
F3I61_RS13795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F3I61_RS13810	COG0357	Ribosomal RNA small subunit methyltransferase G
F3I61_RS13815	COG2894	cell division
F3I61_RS13820	COG1803	Methylglyoxal synthase
F3I61_RS13835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F3I61_RS13845	COG1847	R3H domain protein
F3I61_RS13850	COG0706	membrane insertase activity
F3I61_RS13855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F3I61_RS13865	COG0230	Belongs to the bacterial ribosomal protein bL34 family