locus-tag	class	description
FORMA_RS00005	COG0592	DNA-directed DNA polymerase activity
FORMA_RS00010	COG0488	(ABC) transporter
FORMA_RS00015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FORMA_RS00020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORMA_RS00025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORMA_RS00030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORMA_RS00035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORMA_RS00035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORMA_RS00040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORMA_RS00045	COG1078	dGTPase activity
FORMA_RS00050	COG2204	response regulator
FORMA_RS00055	COG0802	atpase or kinase
FORMA_RS00060	COG0686	Belongs to the AlaDH PNT family
FORMA_RS00075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORMA_RS00080	COG1522	sequence-specific DNA binding
FORMA_RS00110	COG0012	GTP binding
FORMA_RS00115	COG4974	Belongs to the 'phage' integrase family
FORMA_RS00120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORMA_RS00130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORMA_RS00135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORMA_RS00160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORMA_RS00165	COG1136	(ABC) transporter
FORMA_RS00180	COG1234	tRNA 3'-trailer cleavage
FORMA_RS00190	COG0540	Belongs to the ATCase OTCase family
FORMA_RS00195	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FORMA_RS00200	COG1012	belongs to the aldehyde dehydrogenase family
FORMA_RS00205	COG0539	negative regulation of cytoplasmic translation
FORMA_RS00210	COG2823	Periplasmic or secreted lipoprotein
FORMA_RS00210	COG1652	LysM domain
FORMA_RS00215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORMA_RS00225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORMA_RS00230	COG2270	Major facilitator Superfamily
FORMA_RS00235	COG4783	chaperone-mediated protein folding
FORMA_RS00245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORMA_RS00250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORMA_RS00255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORMA_RS00265	COG2234	aminopeptidase activity
FORMA_RS00315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FORMA_RS00320	COG0626	cystathionine gamma-synthase activity
FORMA_RS00330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORMA_RS00335	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORMA_RS00335	COG1333	cytochrome c biogenesis protein
FORMA_RS00350	COG0424	maF-like protein
FORMA_RS00360	COG0037	tRNA processing
FORMA_RS00370	COG0513	Belongs to the DEAD box helicase family
FORMA_RS00375	COG1595	DNA-templated transcription, initiation
FORMA_RS00380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORMA_RS00435	COG0492	ferredoxin-NADP+ reductase activity
FORMA_RS00440	COG0572	uridine kinase
FORMA_RS00450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORMA_RS00455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORMA_RS00455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORMA_RS00460	COG1192	Involved in chromosome partitioning
FORMA_RS00465	COG1192	Involved in chromosome partitioning
FORMA_RS00470	COG1475	DNA binding
FORMA_RS00480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORMA_RS00485	COG0681	Belongs to the peptidase S26 family
FORMA_RS00510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORMA_RS00520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FORMA_RS00530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORMA_RS00545	COG0105	UTP biosynthetic process
FORMA_RS00550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FORMA_RS00560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORMA_RS00565	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORMA_RS00575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FORMA_RS00580	COG1228	amidohydrolase
FORMA_RS00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORMA_RS00590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORMA_RS00600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORMA_RS00610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORMA_RS00640	COG3956	TIGRFAM MazG family protein
FORMA_RS00650	COG0482	sulfurtransferase activity
FORMA_RS00655	COG0706	membrane insertase activity
FORMA_RS00660	COG0504	CTP synthase activity
FORMA_RS00665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORMA_RS00670	COG0514	ATP-dependent DNA helicase (RecQ)
FORMA_RS00675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORMA_RS00675	COG0517	IMP dehydrogenase activity
FORMA_RS00680	COG0805	protein transport
FORMA_RS00690	COG1137	ATPase activity
FORMA_RS00695	COG1253	flavin adenine dinucleotide binding
FORMA_RS00700	COG1183	phosphatidylcholine synthase activity
FORMA_RS00715	COG0488	(ABC) transporter
FORMA_RS00735	COG0653	protein targeting
FORMA_RS00745	COG1703	isobutyryl-CoA mutase activity
FORMA_RS00750	COG0671	phosphoesterase, PA-phosphatase related
FORMA_RS00760	COG0534	Mate efflux family protein
FORMA_RS00770	COG0242	peptide deformylase activity
FORMA_RS00775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORMA_RS00780	COG2171	N-acyltransferase activity
FORMA_RS00800	COG0463	Glycosyl transferase, family 2
FORMA_RS00810	COG0009	L-threonylcarbamoyladenylate synthase
FORMA_RS00815	COG0617	tRNA 3'-terminal CCA addition
FORMA_RS00820	COG1612	heme a metabolic process
FORMA_RS00855	COG0556	nucleotide-excision repair
FORMA_RS00860	COG0045	succinate-CoA ligase (ADP-forming) activity
FORMA_RS00870	COG0019	diaminopimelate decarboxylase activity
FORMA_RS00875	COG1278	Cold shock
FORMA_RS00890	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORMA_RS00910	COG0513	Belongs to the DEAD box helicase family
FORMA_RS00930	COG2115	Belongs to the xylose isomerase family
FORMA_RS00935	COG1070	Carbohydrate kinase
FORMA_RS00955	COG2211	Major facilitator Superfamily
FORMA_RS00970	COG3119	arylsulfatase activity
FORMA_RS00975	COG3119	arylsulfatase activity
FORMA_RS00980	COG3119	arylsulfatase activity
FORMA_RS00990	COG0702	epimerase
FORMA_RS00995	COG4771	TonB-dependent receptor
FORMA_RS01000	COG0745	RESPONSE REGULATOR receiver
FORMA_RS01000	COG2205	protein histidine kinase activity
FORMA_RS01000	COG3292	Two component regulator propeller
FORMA_RS01005	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FORMA_RS01005	COG4124	Belongs to the glycosyl hydrolase 26 family
FORMA_RS01025	COG3119	arylsulfatase activity
FORMA_RS01030	COG3119	arylsulfatase activity
FORMA_RS01035	COG2017	converts alpha-aldose to the beta-anomer
FORMA_RS01060	COG2267	carboxylic ester hydrolase activity
FORMA_RS01075	COG0659	secondary active sulfate transmembrane transporter activity
FORMA_RS01080	COG1741	Belongs to the pirin family
FORMA_RS01110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FORMA_RS01130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORMA_RS01135	COG1085	galactose-1-phosphate uridylyltransferase
FORMA_RS01145	COG3250	beta-galactosidase activity
FORMA_RS01150	COG3734	2-keto-3-deoxy-galactonokinase
FORMA_RS01160	COG3119	arylsulfatase activity
FORMA_RS01180	COG4948	Mandelate Racemase Muconate Lactonizing
FORMA_RS01185	COG1012	belongs to the aldehyde dehydrogenase family
FORMA_RS01195	COG2207	Transcriptional regulator
FORMA_RS01200	COG3119	arylsulfatase activity
FORMA_RS01210	COG3119	arylsulfatase activity
FORMA_RS01220	COG3119	arylsulfatase activity
FORMA_RS01230	COG3250	beta-galactosidase activity
FORMA_RS01235	COG1629	transport
FORMA_RS01245	COG3119	arylsulfatase activity
FORMA_RS01250	COG3119	arylsulfatase activity
FORMA_RS01295	COG1480	7TM receptor with intracellular HD hydrolase
FORMA_RS01300	COG0183	Belongs to the thiolase family
FORMA_RS01305	COG0791	NLP P60 protein
FORMA_RS01315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORMA_RS01320	COG0542	response to heat
FORMA_RS01325	COG2986	histidine ammonia-lyase
FORMA_RS01340	COG0542	response to heat
FORMA_RS01345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORMA_RS01350	COG4771	TonB-dependent receptor
FORMA_RS01355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORMA_RS01360	COG0673	inositol 2-dehydrogenase activity
FORMA_RS01365	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORMA_RS01380	COG2176	DNA-directed DNA polymerase activity
FORMA_RS01385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORMA_RS01390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORMA_RS01425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORMA_RS01430	COG0497	DNA recombination
FORMA_RS01455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORMA_RS01465	COG1525	nuclease
FORMA_RS01465	COG0737	Belongs to the 5'-nucleotidase family
FORMA_RS01465	COG4085	toxin activity
FORMA_RS01470	COG0737	Belongs to the 5'-nucleotidase family
FORMA_RS01475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORMA_RS01480	COG2890	protein-(glutamine-N5) methyltransferase activity
FORMA_RS01490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORMA_RS01490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORMA_RS01495	COG1739	Uncharacterized protein family UPF0029
FORMA_RS01505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORMA_RS01510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORMA_RS01515	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORMA_RS01530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORMA_RS01535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORMA_RS01545	COG0336	Belongs to the RNA methyltransferase TrmD family
FORMA_RS01550	COG0335	large ribosomal subunit rRNA binding
FORMA_RS01570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORMA_RS01585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORMA_RS01590	COG0085	RNA polymerase activity
FORMA_RS01595	COG0222	ribosome binding
FORMA_RS01600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORMA_RS01605	COG0081	regulation of translation
FORMA_RS01610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORMA_RS01650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORMA_RS01655	COG4974	Belongs to the 'phage' integrase family
FORMA_RS01660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORMA_RS01665	COG1960	acyl-CoA dehydrogenase activity
FORMA_RS01675	COG1115	amino acid carrier protein
FORMA_RS01680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORMA_RS01700	COG0577	efflux transmembrane transporter activity
FORMA_RS01705	COG3876	Protein conserved in bacteria
FORMA_RS01735	COG2884	Cell division ATP-binding protein ftsE
FORMA_RS01745	COG1216	Glycosyl transferase, family 2
FORMA_RS01745	COG0463	Glycosyl transferase, family 2
FORMA_RS01750	COG0438	transferase activity, transferring glycosyl groups
FORMA_RS01755	COG2194	sulfuric ester hydrolase activity
FORMA_RS01770	COG1217	gtp-binding protein TYPA
FORMA_RS01775	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORMA_RS01790	COG1668	transmembrane transport
FORMA_RS01795	COG4152	abc transporter atp-binding protein
FORMA_RS01800	COG0484	heat shock protein binding
FORMA_RS01805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORMA_RS01810	COG1090	epimerase
FORMA_RS01825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORMA_RS01845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORMA_RS01855	COG1522	sequence-specific DNA binding
FORMA_RS01865	COG0284	orotidine-5'-phosphate decarboxylase activity
FORMA_RS01870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORMA_RS01875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORMA_RS01885	COG0174	glutamine synthetase
FORMA_RS01895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORMA_RS01910	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORMA_RS01920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORMA_RS01925	COG0793	Belongs to the peptidase S41A family
FORMA_RS01930	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORMA_RS01940	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORMA_RS01945	COG2333	competence protein COMEC
FORMA_RS01945	COG0658	competence protein
FORMA_RS01970	COG0823	Involved in the tonB-independent uptake of proteins
FORMA_RS01970	COG1506	peptidase
FORMA_RS02005	COG1253	flavin adenine dinucleotide binding
FORMA_RS02020	COG0457	Tetratricopeptide repeat
FORMA_RS02030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FORMA_RS02065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FORMA_RS02105	COG2217	Heavy metal translocating P-type atpase
FORMA_RS02115	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORMA_RS02140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORMA_RS02200	COG0629	single-stranded DNA binding
FORMA_RS02215	COG1609	Transcriptional regulator
FORMA_RS02220	COG0004	ammonium transporteR
FORMA_RS02225	COG0347	Belongs to the P(II) protein family
FORMA_RS02230	COG0004	ammonium transporteR
FORMA_RS02240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORMA_RS02240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORMA_RS02245	COG1619	proteins homologs of microcin C7 resistance protein MccF
FORMA_RS02250	COG0792	nuclease activity
FORMA_RS02255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORMA_RS02265	COG1946	Acyl-CoA thioesterase
FORMA_RS02285	COG0415	Belongs to the DNA photolyase family
FORMA_RS02300	COG3118	belongs to the thioredoxin family
FORMA_RS02315	COG0228	four-way junction DNA binding
FORMA_RS02320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORMA_RS02325	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORMA_RS02330	COG1960	acyl-CoA dehydrogenase activity
FORMA_RS02340	COG0633	Ferredoxin
FORMA_RS02345	COG0492	ferredoxin-NADP+ reductase activity
FORMA_RS02350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORMA_RS02355	COG0489	protein tyrosine kinase activity
FORMA_RS02370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORMA_RS02375	COG5002	protein histidine kinase activity
FORMA_RS02380	COG0745	RESPONSE REGULATOR receiver
FORMA_RS02395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORMA_RS02400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORMA_RS02410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FORMA_RS02415	COG0463	Glycosyl transferase, family 2
FORMA_RS02455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORMA_RS02455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORMA_RS02465	COG2264	protein methyltransferase activity
FORMA_RS02470	COG0149	triose-phosphate isomerase activity
FORMA_RS02475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORMA_RS02480	COG0601	transmembrane transport
FORMA_RS02495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORMA_RS02500	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FORMA_RS02505	COG1132	(ABC) transporter
FORMA_RS02510	COG0101	tRNA pseudouridine synthase activity
FORMA_RS02530	COG0268	Binds directly to 16S ribosomal RNA
FORMA_RS02540	COG0442	prolyl-tRNA aminoacylation
FORMA_RS02565	COG0302	gtp cyclohydrolase
FORMA_RS02570	COG0215	cysteine-tRNA ligase activity
FORMA_RS02575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FORMA_RS02580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORMA_RS02585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORMA_RS02590	COG0039	L-malate dehydrogenase activity
FORMA_RS02600	COG0187	DNA topoisomerase II activity
FORMA_RS02610	COG0367	asparagine synthase
FORMA_RS02615	COG0602	queuosine metabolic process
FORMA_RS02620	COG0433	COG0433 Predicted ATPase
FORMA_RS02635	COG1187	pseudouridine synthase activity
FORMA_RS02645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORMA_RS02650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORMA_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
FORMA_RS02670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORMA_RS02675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FORMA_RS02675	COG0515	serine threonine protein kinase
FORMA_RS02690	COG0295	cytidine deaminase activity
FORMA_RS02695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FORMA_RS02715	COG0285	dihydrofolate synthase activity
FORMA_RS02725	COG0848	biopolymer transport protein
FORMA_RS02730	COG0811	peptide transport
FORMA_RS02740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORMA_RS02745	COG1960	acyl-CoA dehydrogenase activity
FORMA_RS02750	COG0463	Glycosyl transferase, family 2
FORMA_RS02785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORMA_RS02790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FORMA_RS02795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORMA_RS02800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FORMA_RS02810	COG0305	Participates in initiation and elongation during chromosome replication
FORMA_RS02815	COG0825	malonyl-CoA metabolic process
FORMA_RS02830	COG0343	queuine tRNA-ribosyltransferase activity
FORMA_RS02835	COG3959	Transketolase, thiamine diphosphate binding domain
FORMA_RS02840	COG3958	Transketolase
FORMA_RS02850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORMA_RS02855	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FORMA_RS02860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORMA_RS02880	COG1233	COG1233 Phytoene dehydrogenase and related
FORMA_RS02900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FORMA_RS02905	COG0714	Associated with various cellular activities
FORMA_RS02910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORMA_RS02920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORMA_RS02925	COG0517	IMP dehydrogenase activity
FORMA_RS02925	COG0516	GMP reductase activity
FORMA_RS02955	COG2356	endonuclease I
FORMA_RS02965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORMA_RS02990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORMA_RS02995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORMA_RS02995	COG0512	Glutamine amidotransferase of anthranilate synthase
FORMA_RS03000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORMA_RS03005	COG0134	indole-3-glycerol-phosphate synthase activity
FORMA_RS03010	COG0135	phosphoribosylanthranilate isomerase activity
FORMA_RS03015	COG0133	tryptophan synthase activity
FORMA_RS03020	COG0159	tryptophan synthase activity
FORMA_RS03030	COG3022	response to hydroperoxide
FORMA_RS03035	COG0564	pseudouridine synthase activity
FORMA_RS03045	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORMA_RS03050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORMA_RS03055	COG0659	secondary active sulfate transmembrane transporter activity
FORMA_RS03065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORMA_RS03075	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FORMA_RS03075	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FORMA_RS03080	COG0799	negative regulation of ribosome biogenesis
FORMA_RS03085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORMA_RS03095	COG4589	Belongs to the CDS family
FORMA_RS03100	COG0688	phosphatidylethanolamine metabolic process
FORMA_RS03110	COG0525	valine-tRNA ligase activity
FORMA_RS03120	COG0436	Aminotransferase
FORMA_RS03125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORMA_RS03130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORMA_RS03155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORMA_RS03160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORMA_RS03165	COG1663	tetraacyldisaccharide 4'-kinase activity
FORMA_RS03170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORMA_RS03195	COG3844	kynureninase activity
FORMA_RS03200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORMA_RS03215	COG1028	Short-chain dehydrogenase reductase Sdr
FORMA_RS03220	COG0662	Cupin 2, conserved barrel domain protein
FORMA_RS03235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORMA_RS03245	COG3340	Belongs to the peptidase S51 family
FORMA_RS03255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORMA_RS03270	COG1477	protein flavinylation
FORMA_RS03285	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORMA_RS03290	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORMA_RS03295	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORMA_RS03300	COG1805	sodium ion transport
FORMA_RS03305	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORMA_RS03320	COG1012	belongs to the aldehyde dehydrogenase family
FORMA_RS03340	COG0357	Ribosomal RNA small subunit methyltransferase G
FORMA_RS03345	COG3239	Fatty acid desaturase
FORMA_RS03350	COG0436	Aminotransferase
FORMA_RS03360	COG0569	domain protein
FORMA_RS03365	COG2226	methyltransferase
FORMA_RS03375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORMA_RS03385	COG0191	fructose-bisphosphate aldolase activity
FORMA_RS03390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORMA_RS03395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORMA_RS03400	COG1185	polyribonucleotide nucleotidyltransferase activity
FORMA_RS03405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORMA_RS03410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORMA_RS03425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FORMA_RS03430	COG3119	arylsulfatase activity
FORMA_RS03435	COG1472	Belongs to the glycosyl hydrolase 3 family
FORMA_RS03445	COG3119	arylsulfatase activity
FORMA_RS03460	COG3119	arylsulfatase activity
FORMA_RS03465	COG0702	epimerase
FORMA_RS03470	COG4771	TonB-dependent receptor
FORMA_RS03480	COG3119	arylsulfatase activity
FORMA_RS03495	COG1595	DNA-templated transcription, initiation
FORMA_RS03505	COG3119	arylsulfatase activity
FORMA_RS03520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORMA_RS03535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORMA_RS03540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORMA_RS03545	COG0772	Belongs to the SEDS family
FORMA_RS03550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORMA_RS03555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORMA_RS03560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORMA_RS03565	COG0768	penicillin binding
FORMA_RS03575	COG0275	rRNA processing
FORMA_RS03580	COG2001	Belongs to the MraZ family
FORMA_RS03590	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORMA_RS03595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORMA_RS03615	COG0018	arginyl-trna synthetase
FORMA_RS03625	COG1834	amidinotransferase
FORMA_RS03635	COG0148	phosphopyruvate hydratase activity
FORMA_RS03640	COG0505	Belongs to the CarA family
FORMA_RS03645	COG0203	ribosomal protein L17
FORMA_RS03650	COG0202	RNA polymerase activity
FORMA_RS03655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FORMA_RS03660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORMA_RS03665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORMA_RS03670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORMA_RS03675	COG0201	protein transport
FORMA_RS03680	COG0200	Binds to the 23S rRNA
FORMA_RS03685	COG1841	ribosomal large subunit assembly
FORMA_RS03690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FORMA_RS03695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FORMA_RS03700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORMA_RS03705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORMA_RS03710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORMA_RS03715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORMA_RS03720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORMA_RS03725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORMA_RS03730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORMA_RS03735	COG0255	Belongs to the universal ribosomal protein uL29 family
FORMA_RS03740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FORMA_RS03745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORMA_RS03750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORMA_RS03755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORMA_RS03760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORMA_RS03765	COG0089	rRNA binding
FORMA_RS03770	COG0088	Forms part of the polypeptide exit tunnel
FORMA_RS03775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORMA_RS03780	COG0051	transcription antitermination factor activity, RNA binding
FORMA_RS03785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORMA_RS03790	COG0049	tRNA binding
FORMA_RS03795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FORMA_RS03815	COG4771	TonB-dependent receptor
FORMA_RS03850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORMA_RS03860	COG1011	Hydrolase
FORMA_RS03870	COG2003	Belongs to the UPF0758 family
FORMA_RS03875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORMA_RS03885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORMA_RS03890	COG0563	adenylate kinase activity
FORMA_RS03895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORMA_RS03900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORMA_RS03905	COG0339	signal peptide processing
FORMA_RS03915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORMA_RS03915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORMA_RS03920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORMA_RS03930	COG1216	Glycosyl transferase, family 2
FORMA_RS03935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORMA_RS03950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORMA_RS03965	COG1160	GTP binding
FORMA_RS03970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORMA_RS03975	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORMA_RS03985	COG0527	aspartate kinase activity
FORMA_RS03995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORMA_RS04000	COG2239	Acts as a magnesium transporter
FORMA_RS04005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORMA_RS04020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORMA_RS04025	COG0196	riboflavin kinase activity
FORMA_RS04030	COG0193	aminoacyl-tRNA hydrolase activity
FORMA_RS04035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORMA_RS04040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORMA_RS04070	COG4771	TonB-dependent receptor
FORMA_RS04075	COG0702	epimerase
FORMA_RS04085	COG4447	cellulose binding
FORMA_RS04085	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FORMA_RS04105	COG2814	Major facilitator Superfamily
FORMA_RS04135	COG1054	Belongs to the UPF0176 family
FORMA_RS04150	COG2226	methyltransferase
FORMA_RS04160	COG0463	Glycosyl transferase, family 2
FORMA_RS04170	COG0463	Glycosyl transferase, family 2
FORMA_RS04175	COG1215	transferase activity, transferring glycosyl groups
FORMA_RS04185	COG1187	pseudouridine synthase activity
FORMA_RS04205	COG2081	HI0933 family
FORMA_RS04230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORMA_RS04235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORMA_RS04245	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORMA_RS04250	COG2363	Small membrane protein
FORMA_RS04260	COG1522	sequence-specific DNA binding
FORMA_RS04275	COG0495	leucyl-tRNA aminoacylation
FORMA_RS04280	COG2177	Part of the ABC transporter FtsEX involved in
FORMA_RS04290	COG1968	undecaprenyl-diphosphatase activity
FORMA_RS04295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORMA_RS04305	COG2326	polyphosphate kinase activity
FORMA_RS04310	COG2326	polyphosphate kinase activity
FORMA_RS04320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FORMA_RS04325	COG5002	protein histidine kinase activity
FORMA_RS04335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORMA_RS04370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FORMA_RS04380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FORMA_RS04385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORMA_RS04390	COG0612	Peptidase, M16
FORMA_RS04395	COG0612	Peptidase, M16
FORMA_RS04420	COG1053	succinate dehydrogenase
FORMA_RS04435	COG1040	competence protein
FORMA_RS04440	COG0423	glycine-tRNA ligase activity
FORMA_RS04455	COG0708	Exodeoxyribonuclease III
FORMA_RS04460	COG1360	Flagellar Motor Protein
FORMA_RS04465	COG0667	Aldo Keto reductase
FORMA_RS04470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORMA_RS04475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORMA_RS04490	COG1490	D-aminoacyl-tRNA deacylase activity
FORMA_RS04495	COG1162	GTPase activity
FORMA_RS04500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FORMA_RS04505	COG0287	Prephenate dehydrogenase
FORMA_RS04510	COG0436	Aminotransferase
FORMA_RS04515	COG0077	Prephenate dehydratase
FORMA_RS04530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORMA_RS04555	COG1428	Deoxynucleoside kinase
FORMA_RS04560	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FORMA_RS04565	COG0022	dehydrogenase e1 component
FORMA_RS04565	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORMA_RS04570	COG2086	electron transfer activity
FORMA_RS04575	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FORMA_RS04585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORMA_RS04590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORMA_RS04595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORMA_RS04600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FORMA_RS04605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORMA_RS04610	COG1228	amidohydrolase
FORMA_RS04650	COG0702	epimerase
FORMA_RS04655	COG1629	transport
FORMA_RS04675	COG0659	secondary active sulfate transmembrane transporter activity
FORMA_RS04690	COG0165	Argininosuccinate lyase
FORMA_RS04695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORMA_RS04700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORMA_RS04710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORMA_RS04715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORMA_RS04725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORMA_RS04730	COG0137	argininosuccinate synthase activity
FORMA_RS04755	COG0477	Major facilitator Superfamily
FORMA_RS04755	COG2814	Major facilitator Superfamily
FORMA_RS04775	COG0702	epimerase
FORMA_RS04780	COG1629	transport
FORMA_RS04800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORMA_RS04810	COG1428	Deoxynucleoside kinase
FORMA_RS04830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORMA_RS04840	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORMA_RS04845	COG0596	Alpha beta hydrolase
FORMA_RS04850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORMA_RS04860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORMA_RS04870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORMA_RS04875	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORMA_RS04890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORMA_RS04920	COG0439	Biotin carboxylase
FORMA_RS04925	COG0511	ligase activity, forming carbon-carbon bonds
FORMA_RS04930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORMA_RS04940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORMA_RS04950	COG1970	mechanosensitive ion channel activity
FORMA_RS04965	COG3239	Fatty acid desaturase
FORMA_RS04985	COG0662	Cupin 2, conserved barrel domain protein
FORMA_RS05080	COG0720	synthase
FORMA_RS05085	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORMA_RS05095	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
FORMA_RS05120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FORMA_RS05120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORMA_RS05135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORMA_RS05140	COG1214	PFAM Peptidase M22, glycoprotease
FORMA_RS05155	COG1136	(ABC) transporter
FORMA_RS05155	COG0577	efflux transmembrane transporter activity
FORMA_RS05160	COG1136	(ABC) transporter
FORMA_RS05160	COG0577	efflux transmembrane transporter activity
FORMA_RS05165	COG1136	(ABC) transporter
FORMA_RS05180	COG2322	membrane
FORMA_RS05185	COG1999	signal sequence binding
FORMA_RS05205	COG1845	cytochrome c oxidase, subunit III
FORMA_RS05210	COG0109	protoheme IX farnesyltransferase activity
FORMA_RS05220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORMA_RS05225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORMA_RS05230	COG0052	Belongs to the universal ribosomal protein uS2 family
FORMA_RS05235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORMA_RS05240	COG0528	UMP kinase activity
FORMA_RS05245	COG0233	cytoplasmic translational termination
FORMA_RS05255	COG0017	Asparaginyl-tRNA synthetase
FORMA_RS05260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FORMA_RS05265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORMA_RS05270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORMA_RS05290	COG1381	Involved in DNA repair and RecF pathway recombination
FORMA_RS05300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FORMA_RS05305	COG0626	cystathionine gamma-synthase activity
FORMA_RS05330	COG1561	YicC-like family, N-terminal region
FORMA_RS05335	COG0194	GDP metabolic process
FORMA_RS05340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORMA_RS05355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORMA_RS05360	COG0346	lactoylglutathione lyase activity
FORMA_RS05450	COG2885	chlorophyll binding
FORMA_RS05465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FORMA_RS05480	COG3341	Caulimovirus viroplasmin
FORMA_RS05480	COG0328	RNA-DNA hybrid ribonuclease activity
FORMA_RS05490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORMA_RS05495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORMA_RS05500	COG0571	ribonuclease III activity
FORMA_RS05510	COG0469	pyruvate kinase activity
FORMA_RS05515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORMA_RS05520	COG2954	triphosphatase activity
FORMA_RS05525	COG1012	belongs to the aldehyde dehydrogenase family
FORMA_RS05545	COG0714	Associated with various cellular activities
FORMA_RS05560	COG2304	oxidoreductase activity
FORMA_RS05565	COG2304	oxidoreductase activity
FORMA_RS05585	COG0659	secondary active sulfate transmembrane transporter activity
FORMA_RS05600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORMA_RS05605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORMA_RS05620	COG1435	thymidine kinase activity
FORMA_RS05625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORMA_RS05630	COG1970	mechanosensitive ion channel activity
FORMA_RS05635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORMA_RS05640	COG3842	ATPase activity
FORMA_RS05645	COG3186	Phenylalanine-4-hydroxylase
FORMA_RS05655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORMA_RS05685	COG0557	exoribonuclease II activity
FORMA_RS05690	COG0698	ribose 5-phosphate isomerase
FORMA_RS05695	COG2153	protein acetylation
FORMA_RS05705	COG0793	Belongs to the peptidase S41A family
FORMA_RS05725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORMA_RS05730	COG0481	GTPase activity
FORMA_RS05735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORMA_RS05745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORMA_RS05750	COG0445	tRNA wobble uridine modification
FORMA_RS05765	COG0126	phosphoglycerate kinase activity
FORMA_RS05770	COG1388	LysM domain
FORMA_RS05770	COG3942	CHAP domain
FORMA_RS05805	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FORMA_RS05815	COG1086	Polysaccharide biosynthesis protein
FORMA_RS05820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORMA_RS05830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORMA_RS05840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORMA_RS05850	COG2089	acid synthase
FORMA_RS05895	COG0438	transferase activity, transferring glycosyl groups
FORMA_RS05935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORMA_RS05955	COG0356	it plays a direct role in the translocation of protons across the membrane
FORMA_RS05960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORMA_RS05965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FORMA_RS05970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORMA_RS05975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORMA_RS05980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORMA_RS06000	COG0756	dUTP diphosphatase activity
FORMA_RS06020	COG1607	acyl-coa hydrolase
FORMA_RS06030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORMA_RS06030	COG0758	DNA mediated transformation
FORMA_RS06045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORMA_RS06055	COG1774	PSP1 C-terminal conserved region
FORMA_RS06070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FORMA_RS06080	COG4172	Belongs to the ABC transporter superfamily
FORMA_RS06095	COG0113	porphobilinogen synthase activity
FORMA_RS06100	COG0408	coproporphyrinogen oxidase activity
FORMA_RS06105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORMA_RS06110	COG0181	hydroxymethylbilane synthase activity
FORMA_RS06115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORMA_RS06125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORMA_RS06135	COG1981	membrane
FORMA_RS06140	COG5000	phosphorelay sensor kinase activity
FORMA_RS06145	COG1024	Enoyl-CoA hydratase
FORMA_RS06160	COG4771	TonB-dependent receptor
FORMA_RS06170	COG0297	glycogen (starch) synthase activity
FORMA_RS06175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORMA_RS06180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FORMA_RS06195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORMA_RS06205	COG0484	heat shock protein binding
FORMA_RS06235	COG1999	signal sequence binding
FORMA_RS06240	COG0750	zinc metalloprotease
FORMA_RS06370	COG0798	PFAM Bile acid sodium symporter
FORMA_RS06385	COG1733	regulation of RNA biosynthetic process
FORMA_RS06410	COG2095	MarC family integral membrane protein
FORMA_RS06425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORMA_RS06425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORMA_RS06440	COG1629	transport
FORMA_RS06440	COG4206	TonB-dependent receptor
FORMA_RS06450	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORMA_RS06455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORMA_RS06460	COG0590	tRNA wobble adenosine to inosine editing
FORMA_RS06470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORMA_RS06490	COG1309	transcriptional regulator
FORMA_RS06505	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORMA_RS06515	COG1446	asparaginase
FORMA_RS06555	COG0779	Required for maturation of 30S ribosomal subunits
FORMA_RS06560	COG0195	Participates in both transcription termination and antitermination
FORMA_RS06565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORMA_RS06580	COG0437	4 iron, 4 sulfur cluster binding
FORMA_RS06610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORMA_RS06615	COG2255	four-way junction helicase activity
FORMA_RS06620	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORMA_RS06625	COG0280	phosphate acetyltransferase
FORMA_RS06625	COG0281	malic enzyme
FORMA_RS06630	COG0632	four-way junction helicase activity
FORMA_RS06640	COG0509	glycine decarboxylation via glycine cleavage system
FORMA_RS06660	COG0084	hydrolase, TatD family'
FORMA_RS06665	COG0252	asparaginase activity
FORMA_RS06675	COG0811	peptide transport
FORMA_RS06685	COG0848	biopolymer transport protein
FORMA_RS06700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORMA_RS06710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORMA_RS06715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORMA_RS06725	COG0189	ligase activity
FORMA_RS06730	COG0322	excinuclease ABC activity
FORMA_RS06735	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORMA_RS06740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORMA_RS06745	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FORMA_RS06755	COG3483	tryptophan 2,3-dioxygenase activity
FORMA_RS06765	COG0166	Belongs to the GPI family
FORMA_RS06770	COG4771	TonB-dependent receptor
FORMA_RS06815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORMA_RS06830	COG2151	metal-sulfur cluster biosynthetic enzyme
FORMA_RS06835	COG2166	iron-sulfur cluster assembly
FORMA_RS06845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORMA_RS06850	COG0719	Fe-S assembly protein
FORMA_RS06855	COG0396	ATPase activity
FORMA_RS06865	COG0719	Fe-S assembly protein
FORMA_RS06870	COG0316	Belongs to the HesB IscA family
FORMA_RS06875	COG1858	cytochrome C peroxidase
FORMA_RS06895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORMA_RS06915	COG1194	a g-specific adenine glycosylase
FORMA_RS06920	COG0776	regulation of translation
FORMA_RS06925	COG1530	ribonuclease E activity
FORMA_RS06935	COG0066	3-isopropylmalate dehydratase activity
FORMA_RS06940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORMA_RS06945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORMA_RS06965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FORMA_RS06975	COG0358	DNA primase activity
FORMA_RS06980	COG2197	response regulator
FORMA_RS06985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORMA_RS07005	COG0772	Belongs to the SEDS family
FORMA_RS07010	COG0768	penicillin binding
FORMA_RS07025	COG1077	Cell shape determining protein MreB Mrl
FORMA_RS07030	COG0138	bifunctional purine biosynthesis protein purh
FORMA_RS07060	COG0459	protein refolding
FORMA_RS07065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORMA_RS07090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORMA_RS07110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FORMA_RS07130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORMA_RS07140	COG0488	(ABC) transporter
FORMA_RS07165	COG0702	epimerase
FORMA_RS07210	COG3250	beta-galactosidase activity
FORMA_RS07220	COG2211	Major facilitator Superfamily
FORMA_RS07245	COG0730	response to heat
FORMA_RS07265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORMA_RS07270	COG0321	lipoyl(octanoyl) transferase activity
FORMA_RS07280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORMA_RS07315	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORMA_RS07320	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FORMA_RS07355	COG0326	Molecular chaperone. Has ATPase activity
FORMA_RS07360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORMA_RS07370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORMA_RS07375	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORMA_RS07385	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORMA_RS07395	COG0179	Fumarylacetoacetate (FAA) hydrolase
FORMA_RS07400	COG1058	Belongs to the CinA family
FORMA_RS07400	COG1546	Belongs to the CinA family
FORMA_RS07405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORMA_RS07410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FORMA_RS07420	COG0552	protein localization to endoplasmic reticulum
FORMA_RS07425	COG0154	amidase activity
FORMA_RS07430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORMA_RS07435	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FORMA_RS07440	COG0519	Catalyzes the synthesis of GMP from XMP
FORMA_RS07440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORMA_RS07455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORMA_RS07470	COG1132	(ABC) transporter
FORMA_RS07475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORMA_RS07485	COG1862	Preprotein translocase
FORMA_RS07490	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORMA_RS07495	COG0167	dihydroorotate dehydrogenase activity
FORMA_RS07510	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORMA_RS07520	COG0067	glutamate synthase
FORMA_RS07520	COG0069	glutamate synthase activity
FORMA_RS07520	COG0070	glutamate synthase
FORMA_RS07545	COG1785	Belongs to the alkaline phosphatase family
FORMA_RS07575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORMA_RS07590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORMA_RS07590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORMA_RS07595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORMA_RS07605	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FORMA_RS07625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORMA_RS07630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORMA_RS07640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORMA_RS07700	COG3206	protein involved in exopolysaccharide biosynthesis
FORMA_RS07700	COG0489	protein tyrosine kinase activity
FORMA_RS07740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORMA_RS07745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORMA_RS07755	COG0205	6-phosphofructokinase activity
FORMA_RS07780	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORMA_RS07780	COG2247	cell wall binding repeat
FORMA_RS07790	COG2181	nitrate reductase activity
FORMA_RS07790	COG0247	lactate metabolic process
FORMA_RS07800	COG2181	nitrate reductase activity
FORMA_RS07800	COG0247	lactate metabolic process
FORMA_RS07815	COG1472	Belongs to the glycosyl hydrolase 3 family
FORMA_RS07820	COG0438	transferase activity, transferring glycosyl groups
FORMA_RS07825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORMA_RS07830	COG1301	dicarboxylic acid transport
FORMA_RS07840	COG3011	Protein conserved in bacteria
FORMA_RS07845	COG1193	negative regulation of DNA recombination
FORMA_RS07850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORMA_RS07875	COG0022	dehydrogenase e1 component
FORMA_RS07890	COG1228	amidohydrolase
FORMA_RS07900	COG1393	Belongs to the ArsC family
FORMA_RS07905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORMA_RS07925	COG0156	8-amino-7-oxononanoate synthase activity
FORMA_RS07960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORMA_RS07965	COG1595	DNA-templated transcription, initiation
FORMA_RS07970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORMA_RS07975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORMA_RS07985	COG0321	lipoyl(octanoyl) transferase activity
FORMA_RS07985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FORMA_RS08015	COG1215	transferase activity, transferring glycosyl groups
FORMA_RS08045	COG0339	signal peptide processing
FORMA_RS08050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORMA_RS08105	COG1960	acyl-CoA dehydrogenase activity
FORMA_RS08110	COG0183	Belongs to the thiolase family
FORMA_RS08115	COG1024	Enoyl-CoA hydratase
FORMA_RS08115	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORMA_RS08130	COG0047	phosphoribosylformylglycinamidine synthase activity
FORMA_RS08130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORMA_RS08140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORMA_RS08140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORMA_RS08150	COG1132	(ABC) transporter
FORMA_RS08155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORMA_RS08160	COG0463	Glycosyl transferase, family 2
FORMA_RS08170	COG0254	rRNA binding
FORMA_RS08180	COG0747	negative chemotaxis
FORMA_RS08185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORMA_RS08195	COG1388	LysM domain
FORMA_RS08195	COG0741	lytic transglycosylase activity
FORMA_RS08205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORMA_RS08305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORMA_RS08310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORMA_RS08320	COG1295	ribonuclease BN
FORMA_RS08325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORMA_RS08330	COG3279	Response regulator of the LytR AlgR family
FORMA_RS08335	COG0360	Binds together with S18 to 16S ribosomal RNA
FORMA_RS08340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FORMA_RS08345	COG0359	binds to the 23S rRNA
FORMA_RS08355	COG0124	histidyl-tRNA synthetase
FORMA_RS08390	COG1678	Uncharacterized ACR, COG1678
FORMA_RS08395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORMA_RS08400	COG0514	ATP-dependent DNA helicase (RecQ)
FORMA_RS08420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORMA_RS08425	COG0415	Belongs to the DNA photolyase family
FORMA_RS08440	COG0386	Belongs to the glutathione peroxidase family
FORMA_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
FORMA_RS08455	COG0302	gtp cyclohydrolase
FORMA_RS08470	COG3046	protein related to deoxyribodipyrimidine photolyase
FORMA_RS08475	COG0415	Belongs to the DNA photolyase family
FORMA_RS08495	COG0606	chelatase, subunit chli
FORMA_RS08500	COG1012	belongs to the aldehyde dehydrogenase family
FORMA_RS08510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORMA_RS08515	COG0443	Heat shock 70 kDa protein
FORMA_RS08530	COG2050	protein possibly involved in aromatic compounds catabolism
FORMA_RS08540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORMA_RS08550	COG0788	formyltetrahydrofolate deformylase activity
FORMA_RS08555	COG2996	Protein conserved in bacteria
FORMA_RS08565	COG1575	Belongs to the MenA family. Type 1 subfamily
FORMA_RS08570	COG4948	Mandelate Racemase Muconate Lactonizing
FORMA_RS08575	COG1266	CAAX protease self-immunity
FORMA_RS08585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORMA_RS08595	COG0488	(ABC) transporter
FORMA_RS08610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORMA_RS08645	COG1104	cysteine desulfurase activity
FORMA_RS08650	COG1629	transport
FORMA_RS08650	COG4206	TonB-dependent receptor
FORMA_RS08655	COG0739	heme binding
FORMA_RS08675	COG1418	mRNA catabolic process
FORMA_RS08700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORMA_RS08705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORMA_RS08705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORMA_RS08720	COG1674	ftsk spoiiie
FORMA_RS08735	COG0450	alkyl hydroperoxide reductase
FORMA_RS08740	COG1757	Na H antiporter
FORMA_RS08745	COG0022	dehydrogenase e1 component
FORMA_RS08755	COG1611	Belongs to the LOG family
FORMA_RS08760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORMA_RS08765	COG0009	L-threonylcarbamoyladenylate synthase
FORMA_RS08770	COG0210	DNA helicase
FORMA_RS08780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORMA_RS08790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORMA_RS08805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORMA_RS08810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORMA_RS08830	COG0277	FAD linked oxidase domain protein
FORMA_RS08840	COG0259	pyridoxamine-phosphate oxidase activity
FORMA_RS08850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FORMA_RS08860	COG0742	ribosomal rna small subunit methyltransferase
FORMA_RS08880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORMA_RS08885	COG1454	alcohol dehydrogenase
FORMA_RS08895	COG0217	transcriptional regulatory protein
FORMA_RS08905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FORMA_RS08910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORMA_RS08915	COG0083	homoserine kinase activity
FORMA_RS08920	COG0460	homoserine dehydrogenase
FORMA_RS08920	COG0527	aspartate kinase activity
FORMA_RS08930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORMA_RS08955	COG0300	oxidoreductase activity
FORMA_RS08960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORMA_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
FORMA_RS08990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORMA_RS08995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORMA_RS09000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORMA_RS09005	COG0131	Imidazoleglycerol-phosphate dehydratase
FORMA_RS09010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORMA_RS09015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORMA_RS09020	COG0107	imidazoleglycerol-phosphate synthase activity
FORMA_RS09025	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORMA_RS09025	COG0140	phosphoribosyl-ATP diphosphatase activity
FORMA_RS09030	COG0101	tRNA pseudouridine synthase activity
FORMA_RS09040	COG0668	transmembrane transport
FORMA_RS09045	COG2814	Major facilitator Superfamily
FORMA_RS09050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FORMA_RS09055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORMA_RS09065	COG0028	Belongs to the TPP enzyme family
FORMA_RS09070	COG0129	dihydroxy-acid dehydratase activity
FORMA_RS09090	COG0116	Belongs to the methyltransferase superfamily
FORMA_RS09090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORMA_RS09110	COG1363	Peptidase, m42
FORMA_RS09115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FORMA_RS09130	COG2267	carboxylic ester hydrolase activity
FORMA_RS09135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORMA_RS09145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORMA_RS09150	COG1702	phosphate starvation-inducible protein PhoH
FORMA_RS09155	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase