locus-tag	class	description
M973_RS00060	COG0084	hydrolase, TatD family'
M973_RS00065	COG3201	nicotinamide mononucleotide transporter
M973_RS00110	COG0542	response to heat
M973_RS00135	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M973_RS00145	COG0204	Acyl-transferase
M973_RS00170	COG0545	Peptidyl-prolyl cis-trans isomerase
M973_RS00185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M973_RS00235	COG0488	(ABC) transporter
M973_RS00295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M973_RS00305	COG0512	Glutamine amidotransferase of anthranilate synthase
M973_RS00375	COG0814	amino acid
M973_RS00385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M973_RS00390	COG0505	Belongs to the CarA family
M973_RS00430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M973_RS00460	COG0284	orotidine-5'-phosphate decarboxylase activity
M973_RS00475	COG1490	D-aminoacyl-tRNA deacylase activity
M973_RS00530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M973_RS00530	COG0574	Belongs to the PEP-utilizing enzyme family
M973_RS00540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M973_RS00550	COG1560	Kdo2-lipid A biosynthetic process
M973_RS00555	COG1560	Kdo2-lipid A biosynthetic process
M973_RS00560	COG0706	membrane insertase activity
M973_RS00585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M973_RS00590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M973_RS00595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M973_RS00620	COG0589	response to stress
M973_RS00690	COG0814	amino acid
M973_RS00695	COG0357	Ribosomal RNA small subunit methyltransferase G
M973_RS00700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M973_RS00715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M973_RS00720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M973_RS00730	COG0268	Binds directly to 16S ribosomal RNA
M973_RS00735	COG0481	GTPase activity
M973_RS00740	COG0482	sulfurtransferase activity
M973_RS00750	COG0242	peptide deformylase activity
M973_RS00760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M973_RS00760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M973_RS00770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M973_RS00770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M973_RS00820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M973_RS00830	COG0629	single-stranded DNA binding
M973_RS00840	COG0280	phosphate acetyltransferase
M973_RS00840	COG0857	belongs to the CobB CobQ family
M973_RS00845	COG1012	belongs to the aldehyde dehydrogenase family
M973_RS00855	COG3153	acetyltransferase
M973_RS00855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M973_RS00860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M973_RS00870	COG0557	exoribonuclease II activity
M973_RS00880	COG0181	hydroxymethylbilane synthase activity
M973_RS00885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M973_RS00905	COG1116	anion transmembrane transporter activity
M973_RS00920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M973_RS00930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M973_RS00965	COG4067	protein conserved in archaea
M973_RS00965	COG0189	ligase activity
M973_RS00980	COG0204	Acyl-transferase
M973_RS00990	COG0009	L-threonylcarbamoyladenylate synthase
M973_RS01000	COG0590	tRNA wobble adenosine to inosine editing
M973_RS01005	COG1181	Belongs to the D-alanine--D-alanine ligase family
M973_RS01010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M973_RS01040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M973_RS01060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M973_RS01070	COG2862	Uncharacterized protein family, UPF0114
M973_RS01075	COG2066	Belongs to the glutaminase family
M973_RS01090	COG3040	lipid binding
M973_RS01095	COG0814	amino acid
M973_RS01100	COG0138	bifunctional purine biosynthesis protein purh
M973_RS01105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M973_RS01150	COG1295	ribonuclease BN
M973_RS01160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M973_RS01165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M973_RS01170	COG1294	oxidase, subunit
M973_RS01175	COG1271	oxidase subunit
M973_RS01190	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M973_RS01200	COG0714	Associated with various cellular activities
M973_RS01220	COG2304	oxidoreductase activity
M973_RS01255	COG0525	valine-tRNA ligase activity
M973_RS01270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M973_RS01290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M973_RS01300	COG0832	Belongs to the urease beta subunit family
M973_RS01305	COG0831	urea catabolic process
M973_RS01315	COG1304	FMN binding
M973_RS01335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M973_RS01360	COG0052	Belongs to the universal ribosomal protein uS2 family
M973_RS01365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M973_RS01375	COG0233	cytoplasmic translational termination
M973_RS01380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M973_RS01385	COG4589	Belongs to the CDS family
M973_RS01390	COG0756	dUTP diphosphatase activity
M973_RS01395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M973_RS01405	COG0049	tRNA binding
M973_RS01410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M973_RS01420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M973_RS01425	COG0088	Forms part of the polypeptide exit tunnel
M973_RS01430	COG0089	rRNA binding
M973_RS01435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M973_RS01440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M973_RS01445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M973_RS01470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M973_RS01475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M973_RS01480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M973_RS01485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M973_RS01490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M973_RS01495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M973_RS01500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M973_RS01515	COG0200	Binds to the 23S rRNA
M973_RS01520	COG0201	protein transport
M973_RS01530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M973_RS01540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M973_RS01550	COG0203	ribosomal protein L17
M973_RS01560	COG0326	Molecular chaperone. Has ATPase activity
M973_RS01575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M973_RS01580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M973_RS01585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M973_RS01600	COG1438	arginine binding
M973_RS01605	COG0165	Argininosuccinate lyase
M973_RS01610	COG0137	argininosuccinate synthase activity
M973_RS01620	COG0504	CTP synthase activity
M973_RS01625	COG0105	UTP biosynthetic process
M973_RS01630	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M973_RS01635	COG0285	dihydrofolate synthase activity
M973_RS01640	COG0802	atpase or kinase
M973_RS01690	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M973_RS01700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M973_RS01720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M973_RS01735	COG0833	amino acid
M973_RS01740	COG2945	thiolester hydrolase activity
M973_RS01745	COG1494	fructose-1,6-bisphosphatase
M973_RS01750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M973_RS01795	COG0215	cysteine-tRNA ligase activity
M973_RS01800	COG2890	protein-(glutamine-N5) methyltransferase activity
M973_RS01810	COG0456	acetyltransferase
M973_RS01820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M973_RS01875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M973_RS01880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M973_RS01885	COG1127	ABC transporter
M973_RS01900	COG0850	regulation of cytokinetic process
M973_RS01905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M973_RS01910	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M973_RS01920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M973_RS01945	COG1051	belongs to the nudix hydrolase family
M973_RS01975	COG2985	domain, Protein
M973_RS01985	COG2885	chlorophyll binding
M973_RS01995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M973_RS02000	COG4401	Chorismate mutase type I
M973_RS02160	COG0352	thiamine-phosphate diphosphorylase activity
M973_RS02165	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M973_RS02170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M973_RS02180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M973_RS02200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M973_RS02210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M973_RS02230	COG0501	Belongs to the peptidase M48B family
M973_RS02235	COG1704	LemA family
M973_RS02240	COG0583	DNA-binding transcription factor activity
M973_RS02260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M973_RS02300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M973_RS02300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M973_RS02315	COG0833	amino acid
M973_RS02320	COG0662	Cupin 2, conserved barrel domain protein
M973_RS02320	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M973_RS02330	COG0436	Aminotransferase
M973_RS02335	COG0497	DNA recombination
M973_RS02350	COG4969	Belongs to the N-Me-Phe pilin family
M973_RS02355	COG0671	phosphoesterase, PA-phosphatase related
M973_RS02360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M973_RS02365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M973_RS02375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M973_RS02395	COG0792	nuclease activity
M973_RS02400	COG0339	signal peptide processing
M973_RS02440	COG1192	Involved in chromosome partitioning
M973_RS02445	COG1475	DNA binding
M973_RS02450	COG0519	Catalyzes the synthesis of GMP from XMP
M973_RS02450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M973_RS02460	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M973_RS02475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M973_RS02485	COG0196	riboflavin kinase activity
M973_RS02490	COG0281	malic enzyme
M973_RS02505	COG1160	GTP binding
M973_RS02510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M973_RS02515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M973_RS02525	COG4106	trans-aconitate 2-methyltransferase activity
M973_RS02535	COG1040	competence protein
M973_RS02540	COG0537	adenosine 5'-monophosphoramidase activity
M973_RS02545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M973_RS02555	COG2226	methyltransferase
M973_RS02560	COG0837	glucose binding
M973_RS02570	COG2917	probably involved in intracellular septation
M973_RS02575	COG0009	L-threonylcarbamoyladenylate synthase
M973_RS02630	COG1994	Peptidase M50
M973_RS02640	COG0688	phosphatidylethanolamine metabolic process
M973_RS02650	COG1051	belongs to the nudix hydrolase family
M973_RS02650	COG1056	cytidyltransferase-related domain
M973_RS02655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M973_RS02660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M973_RS02685	COG0024	Methionine aminopeptidase
M973_RS02700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M973_RS02710	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M973_RS02730	COG0587	DNA-directed DNA polymerase activity
M973_RS02770	COG1982	Orn Lys Arg decarboxylase major
M973_RS02775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M973_RS02785	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M973_RS02805	COG2873	o-acetylhomoserine
M973_RS02820	COG1523	belongs to the glycosyl hydrolase 13 family
M973_RS02825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M973_RS02830	COG0033	Phosphoglucomutase
M973_RS02835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M973_RS02840	COG0297	glycogen (starch) synthase activity
M973_RS02845	COG0058	SHG alpha-glucan phosphorylase activity
M973_RS02850	COG1640	4-alpha-glucanotransferase
M973_RS02865	COG0752	glycyl-tRNA synthetase alpha subunit
M973_RS02880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M973_RS02890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M973_RS02895	COG0460	homoserine dehydrogenase
M973_RS02895	COG0527	aspartate kinase activity
M973_RS02905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M973_RS02920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M973_RS02925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M973_RS02950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M973_RS02955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M973_RS02980	COG0488	(ABC) transporter
M973_RS02990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M973_RS02995	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M973_RS03000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M973_RS03005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M973_RS03010	COG0772	Belongs to the SEDS family
M973_RS03020	COG0463	Glycosyl transferase, family 2
M973_RS03030	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M973_RS03040	COG0625	glutathione transferase activity
M973_RS03045	COG0616	signal peptide processing
M973_RS03050	COG0470	DNA polymerase III
M973_RS03060	COG0113	porphobilinogen synthase activity
M973_RS03065	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M973_RS03100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M973_RS03105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M973_RS03110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M973_RS03115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M973_RS03125	COG0439	Biotin carboxylase
M973_RS03135	COG0668	transmembrane transport
M973_RS03140	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M973_RS03145	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M973_RS03145	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M973_RS03150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M973_RS03160	COG0531	amino acid
M973_RS03190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M973_RS03205	COG0492	ferredoxin-NADP+ reductase activity
M973_RS03270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M973_RS03275	COG0045	succinate-CoA ligase (ADP-forming) activity
M973_RS03290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M973_RS03305	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M973_RS03310	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M973_RS03315	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M973_RS03320	COG0318	PFAM AMP-dependent synthetase and ligase
M973_RS03320	COG0204	Acyl-transferase
M973_RS03325	COG0275	rRNA processing
M973_RS03330	COG3116	cell division
M973_RS03340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M973_RS03345	COG1185	polyribonucleotide nucleotidyltransferase activity
M973_RS03350	COG0316	Belongs to the HesB IscA family
M973_RS03355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M973_RS03360	COG0572	uridine kinase
M973_RS03365	COG1758	RNA polymerase activity
M973_RS03390	COG1940	carbohydrate kinase activity
M973_RS03420	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M973_RS03425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M973_RS03430	COG0814	amino acid
M973_RS03435	COG1063	alcohol dehydrogenase
M973_RS03440	COG0156	8-amino-7-oxononanoate synthase activity
M973_RS03445	COG0534	Mate efflux family protein
M973_RS03455	COG0477	Major facilitator Superfamily
M973_RS03460	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M973_RS03465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M973_RS03475	COG2271	Major facilitator Superfamily
M973_RS03480	COG0584	glycerophosphoryl diester phosphodiesterase
M973_RS03510	COG0251	oxidation-reduction process
M973_RS03535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M973_RS03540	COG4988	ABC transporter
M973_RS03565	COG1940	carbohydrate kinase activity
M973_RS03590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M973_RS03595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M973_RS03600	COG0277	FAD linked oxidase domain protein
M973_RS03600	COG0247	lactate metabolic process
M973_RS03615	COG0295	cytidine deaminase activity
M973_RS03620	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M973_RS03630	COG2860	membrane
M973_RS03635	COG0742	ribosomal rna small subunit methyltransferase
M973_RS03645	COG0612	Peptidase, M16
M973_RS03650	COG0795	lipopolysaccharide-transporting ATPase activity
M973_RS03655	COG0795	lipopolysaccharide-transporting ATPase activity
M973_RS03660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M973_RS03665	COG0517	IMP dehydrogenase activity
M973_RS03665	COG0516	GMP reductase activity
M973_RS03675	COG0166	Belongs to the GPI family
M973_RS03685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M973_RS03690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M973_RS03700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M973_RS03705	COG0813	purine-nucleoside phosphorylase activity
M973_RS03720	COG0653	protein targeting
M973_RS03725	COG0519	Catalyzes the synthesis of GMP from XMP
M973_RS03730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M973_RS03735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M973_RS03745	COG1177	transmembrane transport
M973_RS03750	COG1176	ABC-type spermidine putrescine transport system, permease component I
M973_RS03755	COG3842	ATPase activity
M973_RS03790	COG3104	oligopeptide transport
M973_RS03795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M973_RS03800	COG0531	amino acid
M973_RS03805	COG1605	Chorismate mutase
M973_RS03805	COG0077	Prephenate dehydratase
M973_RS03820	COG1760	l-serine dehydratase
M973_RS03825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M973_RS03830	COG0316	Belongs to the HesB IscA family
M973_RS03835	COG2151	metal-sulfur cluster biosynthetic enzyme
M973_RS03840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M973_RS03845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M973_RS03870	COG1546	Belongs to the CinA family
M973_RS03870	COG1058	Belongs to the CinA family
M973_RS03875	COG0189	ligase activity
M973_RS03875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M973_RS03880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M973_RS03880	COG1181	Belongs to the D-alanine--D-alanine ligase family
M973_RS03885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M973_RS03890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M973_RS03895	COG0814	amino acid
M973_RS03900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M973_RS03905	COG0343	queuine tRNA-ribosyltransferase activity
M973_RS03920	COG1335	isochorismatase
M973_RS03940	COG1862	Preprotein translocase
M973_RS03945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M973_RS03950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M973_RS03960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M973_RS03975	COG0328	RNA-DNA hybrid ribonuclease activity
M973_RS03980	COG0252	asparaginase activity
M973_RS03985	COG0288	reversible hydration of carbon dioxide
M973_RS04000	COG0544	peptidyl-prolyl cis-trans isomerase activity
M973_RS04005	COG0740	serine-type endopeptidase activity
M973_RS04010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M973_RS04030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M973_RS04035	COG1923	regulation of RNA biosynthetic process
M973_RS04040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M973_RS04050	COG0330	HflC and HflK could
M973_RS04055	COG0330	HflC and HflK could
M973_RS04060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M973_RS04065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M973_RS04080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M973_RS04090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M973_RS04115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M973_RS04120	COG0670	Belongs to the BI1 family
M973_RS04135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M973_RS04140	COG2878	Part of a membrane complex involved in electron transport
M973_RS04145	COG2999	glutathione oxidoreductase activity
M973_RS04155	COG1528	Iron-storage protein
M973_RS04160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M973_RS04165	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M973_RS04170	COG0217	transcriptional regulatory protein
M973_RS04175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M973_RS04180	COG2271	Major facilitator Superfamily
M973_RS04190	COG1322	Protein conserved in bacteria
M973_RS04235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M973_RS04240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M973_RS04245	COG4536	flavin adenine dinucleotide binding
M973_RS04260	COG0193	aminoacyl-tRNA hydrolase activity
M973_RS04275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M973_RS04285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M973_RS04295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M973_RS04300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M973_RS04310	COG0095	Lipoate-protein ligase
M973_RS04315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M973_RS04330	COG2301	Belongs to the HpcH HpaI aldolase family
M973_RS04340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M973_RS04365	COG1566	PFAM secretion protein HlyD family protein
M973_RS04380	COG1509	lysine 2,3-aminomutase activity
M973_RS04390	COG1278	Cold shock
M973_RS04415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M973_RS04420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M973_RS04425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M973_RS04460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M973_RS04465	COG0084	hydrolase, TatD family'
M973_RS04470	COG0751	glycine-tRNA ligase activity
M973_RS04480	COG2814	Major facilitator Superfamily
M973_RS04510	COG0301	tRNA thio-modification
M973_RS04520	COG2835	tetraacyldisaccharide 4'-kinase activity
M973_RS04525	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M973_RS04545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M973_RS04555	COG2814	Major facilitator Superfamily
M973_RS04560	COG2814	Major facilitator Superfamily
M973_RS04565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M973_RS04570	COG0513	Belongs to the DEAD box helicase family
M973_RS04580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M973_RS04590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M973_RS04605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M973_RS04610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M973_RS04615	COG0408	coproporphyrinogen oxidase activity
M973_RS04620	COG1054	Belongs to the UPF0176 family
M973_RS04780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M973_RS04780	COG0116	Belongs to the methyltransferase superfamily
M973_RS04785	COG2076	Multidrug Resistance protein
M973_RS04800	COG0640	Transcriptional regulator
M973_RS04810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M973_RS04815	COG0189	ligase activity
M973_RS04820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M973_RS04830	COG1959	2 iron, 2 sulfur cluster binding
M973_RS04835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M973_RS04835	COG1017	nitric oxide dioxygenase activity
M973_RS04840	COG1472	Belongs to the glycosyl hydrolase 3 family
M973_RS04885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M973_RS04885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M973_RS04895	COG0318	PFAM AMP-dependent synthetase and ligase
M973_RS04900	COG0512	Glutamine amidotransferase of anthranilate synthase
M973_RS04900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M973_RS04905	COG0512	Glutamine amidotransferase of anthranilate synthase
M973_RS04905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M973_RS04945	COG3104	oligopeptide transport
M973_RS04950	COG0393	Putative heavy-metal-binding
M973_RS04955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M973_RS04970	COG0708	Exodeoxyribonuclease III
M973_RS04990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M973_RS04995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M973_RS05005	COG0730	response to heat
M973_RS05020	COG0531	amino acid
M973_RS05025	COG0569	domain protein
M973_RS05035	COG0719	Fe-S assembly protein
M973_RS05040	COG0396	ATPase activity
M973_RS05045	COG0719	Fe-S assembly protein
M973_RS05055	COG3118	belongs to the thioredoxin family
M973_RS05065	COG0833	amino acid
M973_RS05075	COG0494	nUDIX hydrolase
M973_RS05080	COG1678	Uncharacterized ACR, COG1678
M973_RS05085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M973_RS05090	COG0495	leucyl-tRNA aminoacylation
M973_RS05100	COG0668	transmembrane transport
M973_RS05105	COG0717	Belongs to the dCTP deaminase family
M973_RS05110	COG0489	protein tyrosine kinase activity
M973_RS05125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M973_RS05160	COG0730	response to heat
M973_RS05165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M973_RS05165	COG0072	phenylalanine-tRNA ligase activity
M973_RS05170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M973_RS05205	COG3655	Transcriptional regulator
M973_RS05215	COG2255	four-way junction helicase activity
M973_RS05230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M973_RS05235	COG0519	Catalyzes the synthesis of GMP from XMP
M973_RS05235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M973_RS05240	COG0101	tRNA pseudouridine synthase activity
M973_RS05255	COG1137	ATPase activity
M973_RS05270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M973_RS05275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M973_RS05280	COG1686	Belongs to the peptidase S11 family
M973_RS05285	COG2921	Belongs to the UPF0250 family
M973_RS05310	COG1610	YqeY-like protein
M973_RS05320	COG2027	D-alanyl-D-alanine carboxypeptidase
M973_RS05335	COG0037	tRNA processing
M973_RS05345	COG0142	geranyltranstransferase activity
M973_RS05370	COG1187	pseudouridine synthase activity
M973_RS05380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M973_RS05390	COG0359	binds to the 23S rRNA
M973_RS05395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M973_RS05400	COG0360	Binds together with S18 to 16S ribosomal RNA
M973_RS05405	COG2996	Protein conserved in bacteria
M973_RS05410	COG0210	DNA helicase
M973_RS05415	COG0354	folic acid binding
M973_RS05430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M973_RS05440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M973_RS05450	COG0210	DNA helicase
M973_RS05480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M973_RS05495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M973_RS05545	COG4948	Mandelate Racemase Muconate Lactonizing
M973_RS05560	COG0386	Belongs to the glutathione peroxidase family
M973_RS05585	COG0583	DNA-binding transcription factor activity
M973_RS05615	COG1876	peptidase activity
M973_RS05640	COG0450	alkyl hydroperoxide reductase
M973_RS05655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M973_RS05685	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
M973_RS05695	COG0039	L-malate dehydrogenase activity
M973_RS05705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M973_RS05710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M973_RS05725	COG0488	(ABC) transporter
M973_RS05765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M973_RS05770	COG2264	protein methyltransferase activity
M973_RS05790	COG0415	Belongs to the DNA photolyase family
M973_RS05795	COG0148	phosphopyruvate hydratase activity
M973_RS05805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M973_RS05825	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M973_RS05845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M973_RS05875	COG0563	adenylate kinase activity
M973_RS05880	COG0277	FAD linked oxidase domain protein
M973_RS05885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M973_RS05890	COG0436	Aminotransferase
M973_RS05900	COG1214	PFAM Peptidase M22, glycoprotease
M973_RS05910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M973_RS05925	COG4122	O-methyltransferase activity
M973_RS05930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M973_RS05935	COG1702	phosphate starvation-inducible protein PhoH
M973_RS05950	COG4535	Mg2 and Co2 transporter CorC
M973_RS05955	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M973_RS05980	COG1496	oxidoreductase activity
M973_RS06005	COG2814	Major facilitator Superfamily
M973_RS06010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M973_RS06015	COG1823	symporter activity
M973_RS06020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M973_RS06050	COG1217	gtp-binding protein TYPA
M973_RS06055	COG1028	Short-chain dehydrogenase reductase Sdr
M973_RS06075	COG0405	Gamma-glutamyltransferase
M973_RS06085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M973_RS06085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M973_RS06090	COG2914	Belongs to the UPF0125 (RnfH) family
M973_RS06095	COG2867	negative regulation of translational initiation
M973_RS06100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M973_RS06105	COG0037	tRNA processing
M973_RS06110	COG0076	glutamate decarboxylase activity
M973_RS06155	COG1570	exodeoxyribonuclease VII activity
M973_RS06190	COG0477	Major facilitator Superfamily
M973_RS06205	COG0556	nucleotide-excision repair
M973_RS06210	COG2925	Exonuclease
M973_RS06235	COG0445	tRNA wobble uridine modification
M973_RS06250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M973_RS06275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M973_RS06285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M973_RS06290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M973_RS06305	COG0509	glycine decarboxylation via glycine cleavage system
M973_RS06310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M973_RS06325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M973_RS06385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M973_RS06420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M973_RS06445	COG2089	acid synthase
M973_RS06450	COG1083	cytidylyl-transferase
M973_RS06460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M973_RS06480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M973_RS06490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M973_RS06495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M973_RS06495	COG0517	IMP dehydrogenase activity
M973_RS06510	COG3220	belongs to the UPF0276 family
M973_RS06530	COG1611	Belongs to the LOG family
M973_RS06550	COG0346	lactoylglutathione lyase activity
M973_RS06555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M973_RS06580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M973_RS06595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M973_RS06600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M973_RS06605	COG3079	Belongs to the UPF0149 family
M973_RS06620	COG0586	Pfam SNARE associated Golgi protein
M973_RS06625	COG0586	Pfam SNARE associated Golgi protein
M973_RS06630	COG1381	Involved in DNA repair and RecF pathway recombination
M973_RS06640	COG1104	cysteine desulfurase activity
M973_RS06645	COG1530	ribonuclease E activity
M973_RS06650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M973_RS06655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M973_RS06660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M973_RS06665	COG0037	tRNA processing
M973_RS06670	COG3104	oligopeptide transport
M973_RS06700	COG3028	Belongs to the UPF0307 family
M973_RS06720	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M973_RS06725	COG0564	pseudouridine synthase activity
M973_RS06735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M973_RS06740	COG1127	ABC transporter
M973_RS06760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M973_RS06780	COG0477	Major facilitator Superfamily
M973_RS06795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M973_RS06810	COG0484	heat shock protein binding
M973_RS06815	COG0443	Heat shock 70 kDa protein
M973_RS06820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M973_RS06825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M973_RS06840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M973_RS06845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M973_RS06875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M973_RS06900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M973_RS06910	COG0583	DNA-binding transcription factor activity
M973_RS06920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M973_RS07055	COG0191	fructose-bisphosphate aldolase activity
M973_RS07060	COG0469	pyruvate kinase activity
M973_RS07065	COG0126	phosphoglycerate kinase activity
M973_RS07080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M973_RS07085	COG0416	fatty acid biosynthetic process
M973_RS07095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M973_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
M973_RS07105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M973_RS07110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M973_RS07130	COG2855	membrane
M973_RS07135	COG0483	inositol monophosphate 1-phosphatase activity
M973_RS07140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M973_RS07140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M973_RS07170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M973_RS07185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M973_RS07190	COG1074	ATP-dependent DNA helicase activity
M973_RS07215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M973_RS07220	COG0069	glutamate synthase activity
M973_RS07265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M973_RS07285	COG2166	iron-sulfur cluster assembly
M973_RS07300	COG0442	prolyl-tRNA aminoacylation
M973_RS07315	COG0436	Aminotransferase
M973_RS07340	COG2983	Belongs to the UPF0260 family
M973_RS07380	COG0402	S-adenosylhomocysteine deaminase activity
M973_RS07395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M973_RS07400	COG1280	lysine exporter protein (LysE YggA)
M973_RS07410	COG0463	Glycosyl transferase, family 2
M973_RS07415	COG0842	Transport permease protein
M973_RS07420	COG1131	(ABC) transporter
M973_RS07430	COG0730	response to heat
M973_RS07445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M973_RS07445	COG3264	Mechanosensitive ion channel
M973_RS07460	COG0084	hydrolase, TatD family'
M973_RS07480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M973_RS07485	COG0248	Ppx GppA phosphatase
M973_RS07525	COG1216	Glycosyl transferase, family 2
M973_RS07535	COG1682	transport, permease protein
M973_RS07545	COG2755	lipolytic protein G-D-S-L family
M973_RS07545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M973_RS07555	COG1442	glycosyl transferase family 8
M973_RS07555	COG1216	Glycosyl transferase, family 2
M973_RS07585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M973_RS07600	COG1028	Short-chain dehydrogenase reductase Sdr
M973_RS07640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M973_RS07660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M973_RS07675	COG1088	dTDP-glucose 4,6-dehydratase activity
M973_RS07695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M973_RS07700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
M973_RS07705	COG0662	Cupin 2, conserved barrel domain protein
M973_RS07705	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
M973_RS07715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M973_RS07720	COG1086	Polysaccharide biosynthesis protein
M973_RS07725	COG1643	Atp-dependent helicase
M973_RS07740	COG0318	PFAM AMP-dependent synthetase and ligase
M973_RS07745	COG1960	acyl-CoA dehydrogenase activity
M973_RS07750	COG1250	3-hydroxyacyl-CoA dehydrogenase
M973_RS07750	COG1024	Enoyl-CoA hydratase
M973_RS07755	COG0183	Belongs to the thiolase family
M973_RS07780	COG0010	Belongs to the arginase family
M973_RS07810	COG0500	methyltransferase
M973_RS07855	COG1028	Short-chain dehydrogenase reductase Sdr
M973_RS07865	COG0557	exoribonuclease II activity
M973_RS07875	COG0571	ribonuclease III activity
M973_RS07880	COG0681	Belongs to the peptidase S26 family
M973_RS07890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M973_RS07895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M973_RS07900	COG1519	Transferase
M973_RS07905	COG0142	geranyltranstransferase activity
M973_RS07910	COG1183	phosphatidylcholine synthase activity
M973_RS07960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M973_RS07965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M973_RS07970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M973_RS08020	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M973_RS08030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M973_RS08035	COG0508	dehydrogenase complex catalyzes the overall conversion of
M973_RS08050	COG0237	dephospho-CoA kinase activity
M973_RS08070	COG0180	Tryptophanyl-tRNA synthetase
M973_RS08095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M973_RS08115	COG0825	malonyl-CoA metabolic process
M973_RS08120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M973_RS08130	COG0814	amino acid
M973_RS08135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M973_RS08140	COG0742	ribosomal rna small subunit methyltransferase
M973_RS08160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M973_RS08170	COG0814	amino acid
M973_RS08195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M973_RS08200	COG0398	Pfam SNARE associated Golgi protein
M973_RS08210	COG0531	amino acid
M973_RS08225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M973_RS08235	COG2081	HI0933 family
M973_RS08255	COG0300	oxidoreductase activity
M973_RS08265	COG0459	protein refolding
M973_RS08270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M973_RS08285	COG1918	ferrous iron import across plasma membrane
M973_RS08290	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M973_RS08305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M973_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
M973_RS08320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M973_RS08335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M973_RS08340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M973_RS08360	COG0463	Glycosyl transferase, family 2
M973_RS08400	COG3022	response to hydroperoxide
M973_RS08405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M973_RS08410	COG2890	protein-(glutamine-N5) methyltransferase activity
M973_RS08415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M973_RS08420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M973_RS08430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M973_RS08435	COG2814	Major facilitator Superfamily
M973_RS08445	COG0814	amino acid
M973_RS08465	COG0494	nUDIX hydrolase
M973_RS08500	COG4974	Belongs to the 'phage' integrase family
M973_RS08505	COG0335	large ribosomal subunit rRNA binding
M973_RS08510	COG0336	Belongs to the RNA methyltransferase TrmD family
M973_RS08515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M973_RS08520	COG0228	four-way junction DNA binding
M973_RS08525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M973_RS08535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M973_RS08545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M973_RS08550	COG0085	RNA polymerase activity
M973_RS08555	COG0222	ribosome binding
M973_RS08560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M973_RS08565	COG0081	regulation of translation
M973_RS08570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M973_RS08580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M973_RS08590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M973_RS08625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M973_RS08630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M973_RS08635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M973_RS08650	COG2814	Major facilitator Superfamily
M973_RS08675	COG0210	DNA helicase
M973_RS08680	COG0552	protein localization to endoplasmic reticulum
M973_RS08690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M973_RS08695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M973_RS08705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M973_RS08710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M973_RS08715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M973_RS08725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M973_RS08725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M973_RS08730	COG1663	tetraacyldisaccharide 4'-kinase activity
M973_RS08750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M973_RS08755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M973_RS08780	COG0642	Histidine kinase
M973_RS08785	COG1090	epimerase
M973_RS08790	COG1271	oxidase subunit
M973_RS08800	COG1294	oxidase, subunit
M973_RS08810	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
M973_RS08840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M973_RS08865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M973_RS08870	COG0149	triose-phosphate isomerase activity
M973_RS08875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M973_RS08880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M973_RS08895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M973_RS08900	COG1053	succinate dehydrogenase
M973_RS08905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M973_RS08910	COG2009	succinate dehydrogenase
M973_RS08920	COG2223	nitrite transmembrane transporter activity
M973_RS08925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M973_RS08930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M973_RS08940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M973_RS08945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M973_RS08950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M973_RS08955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M973_RS08960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M973_RS08965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M973_RS08990	COG0564	pseudouridine synthase activity
M973_RS08995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M973_RS09005	COG0124	histidyl-tRNA synthetase
M973_RS09010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M973_RS09015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M973_RS09020	COG0195	Participates in both transcription termination and antitermination
M973_RS09020	COG2251	uridine kinase activity
M973_RS09025	COG0779	Required for maturation of 30S ribosomal subunits
M973_RS09035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M973_RS09065	COG0713	ATP synthesis coupled electron transport
M973_RS09070	COG0839	Belongs to the complex I subunit 6 family
M973_RS09075	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M973_RS09080	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M973_RS09085	COG1034	ATP synthesis coupled electron transport
M973_RS09095	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M973_RS09100	COG0649	NAD binding
M973_RS09105	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M973_RS09115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M973_RS09190	COG0154	amidase activity
M973_RS09195	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M973_RS09210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M973_RS09220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M973_RS09220	COG0047	phosphoribosylformylglycinamidine synthase activity
M973_RS09225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M973_RS09240	COG1538	Outer membrane efflux protein
M973_RS09250	COG0826	peptidase U32
M973_RS09270	COG2814	Major facilitator Superfamily
M973_RS09275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M973_RS09280	COG4178	(ABC) transporter
M973_RS09285	COG0531	amino acid
M973_RS09290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M973_RS09295	COG0814	amino acid
M973_RS09315	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M973_RS09320	COG1733	regulation of RNA biosynthetic process
M973_RS09335	COG2271	Major facilitator Superfamily
M973_RS09430	COG0179	Fumarylacetoacetate (FAA) hydrolase
M973_RS09480	COG0730	response to heat
M973_RS09485	COG0730	response to heat