locus-tag	class	description
KU46_RS00010	COG2755	lipolytic protein G-D-S-L family
KU46_RS00010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KU46_RS00015	COG2755	lipolytic protein G-D-S-L family
KU46_RS00015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KU46_RS00025	COG0436	Aminotransferase
KU46_RS00055	COG2983	Belongs to the UPF0260 family
KU46_RS00075	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU46_RS00080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KU46_RS00095	COG0402	S-adenosylhomocysteine deaminase activity
KU46_RS00110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KU46_RS00115	COG1280	lysine exporter protein (LysE YggA)
KU46_RS00125	COG0463	Glycosyl transferase, family 2
KU46_RS00130	COG0842	Transport permease protein
KU46_RS00135	COG1131	(ABC) transporter
KU46_RS00145	COG0730	response to heat
KU46_RS00160	COG0084	hydrolase, TatD family'
KU46_RS00185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KU46_RS00190	COG0248	Ppx GppA phosphatase
KU46_RS00215	COG0438	transferase activity, transferring glycosyl groups
KU46_RS00220	COG0438	transferase activity, transferring glycosyl groups
KU46_RS00230	COG1216	Glycosyl transferase, family 2
KU46_RS00245	COG0438	transferase activity, transferring glycosyl groups
KU46_RS00250	COG1216	Glycosyl transferase, family 2
KU46_RS00285	COG1682	transport, permease protein
KU46_RS00290	COG1088	dTDP-glucose 4,6-dehydratase activity
KU46_RS00310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KU46_RS00320	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KU46_RS00340	COG1086	Polysaccharide biosynthesis protein
KU46_RS00345	COG1643	Atp-dependent helicase
KU46_RS00360	COG0318	PFAM AMP-dependent synthetase and ligase
KU46_RS00365	COG1960	acyl-CoA dehydrogenase activity
KU46_RS00370	COG1024	Enoyl-CoA hydratase
KU46_RS00370	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU46_RS00375	COG0183	Belongs to the thiolase family
KU46_RS00400	COG0010	Belongs to the arginase family
KU46_RS00430	COG0500	methyltransferase
KU46_RS00450	COG5002	protein histidine kinase activity
KU46_RS00465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KU46_RS00490	COG0557	exoribonuclease II activity
KU46_RS00495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KU46_RS00500	COG0571	ribonuclease III activity
KU46_RS00505	COG0681	Belongs to the peptidase S26 family
KU46_RS00515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KU46_RS00520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KU46_RS00525	COG1519	Transferase
KU46_RS00530	COG0142	geranyltranstransferase activity
KU46_RS00535	COG1183	phosphatidylcholine synthase activity
KU46_RS00555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU46_RS00560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU46_RS00565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KU46_RS00620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KU46_RS00625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU46_RS00630	COG0508	dehydrogenase complex catalyzes the overall conversion of
KU46_RS00685	COG3328	transposase activity
KU46_RS00715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KU46_RS00720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KU46_RS00725	COG2089	acid synthase
KU46_RS00735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KU46_RS00770	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KU46_RS00790	COG0300	oxidoreductase activity
KU46_RS00795	COG1368	sulfuric ester hydrolase activity
KU46_RS00805	COG2124	cytochrome p450
KU46_RS00820	COG0156	8-amino-7-oxononanoate synthase activity
KU46_RS00835	COG0237	dephospho-CoA kinase activity
KU46_RS00855	COG0180	Tryptophanyl-tRNA synthetase
KU46_RS00875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KU46_RS00895	COG0825	malonyl-CoA metabolic process
KU46_RS00900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KU46_RS00910	COG0814	amino acid
KU46_RS00915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KU46_RS00920	COG0742	ribosomal rna small subunit methyltransferase
KU46_RS00940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KU46_RS00950	COG0814	amino acid
KU46_RS01000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU46_RS01005	COG0398	Pfam SNARE associated Golgi protein
KU46_RS01010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KU46_RS01015	COG0531	amino acid
KU46_RS01030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KU46_RS01035	COG2814	Major facilitator Superfamily
KU46_RS01040	COG2081	HI0933 family
KU46_RS01055	COG1404	Belongs to the peptidase S8 family
KU46_RS01060	COG0300	oxidoreductase activity
KU46_RS01065	COG0531	amino acid
KU46_RS01070	COG0459	protein refolding
KU46_RS01075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KU46_RS01090	COG1918	ferrous iron import across plasma membrane
KU46_RS01095	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KU46_RS01110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KU46_RS01115	COG1028	Short-chain dehydrogenase reductase Sdr
KU46_RS01125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KU46_RS01140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU46_RS01145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU46_RS01165	COG0463	Glycosyl transferase, family 2
KU46_RS01205	COG3022	response to hydroperoxide
KU46_RS01210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KU46_RS01215	COG2890	protein-(glutamine-N5) methyltransferase activity
KU46_RS01220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KU46_RS01225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KU46_RS01235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KU46_RS01240	COG2814	Major facilitator Superfamily
KU46_RS01250	COG0814	amino acid
KU46_RS01255	COG3681	Belongs to the UPF0597 family
KU46_RS01260	COG3023	N-Acetylmuramoyl-L-alanine amidase
KU46_RS01270	COG0494	nUDIX hydrolase
KU46_RS01280	COG4221	oxidoreductase activity
KU46_RS01305	COG4974	Belongs to the 'phage' integrase family
KU46_RS01310	COG0335	large ribosomal subunit rRNA binding
KU46_RS01315	COG0336	Belongs to the RNA methyltransferase TrmD family
KU46_RS01320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KU46_RS01325	COG0228	four-way junction DNA binding
KU46_RS01330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KU46_RS01340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KU46_RS01350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KU46_RS01355	COG0085	RNA polymerase activity
KU46_RS01360	COG0222	ribosome binding
KU46_RS01365	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KU46_RS01370	COG0081	regulation of translation
KU46_RS01375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KU46_RS01385	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KU46_RS01395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KU46_RS01415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KU46_RS01430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KU46_RS01435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KU46_RS01440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KU46_RS01455	COG2814	Major facilitator Superfamily
KU46_RS01460	COG4608	Belongs to the ABC transporter superfamily
KU46_RS01470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KU46_RS01475	COG0601	transmembrane transport
KU46_RS01480	COG4166	transmembrane transport
KU46_RS01485	COG0210	DNA helicase
KU46_RS01490	COG0552	protein localization to endoplasmic reticulum
KU46_RS01500	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KU46_RS01505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KU46_RS01510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KU46_RS01515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KU46_RS01520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KU46_RS01525	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KU46_RS01535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KU46_RS01535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KU46_RS01540	COG1663	tetraacyldisaccharide 4'-kinase activity
KU46_RS01560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU46_RS01565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KU46_RS01590	COG0642	Histidine kinase
KU46_RS01595	COG1090	epimerase
KU46_RS01600	COG1271	oxidase subunit
KU46_RS01605	COG1294	oxidase, subunit
KU46_RS01615	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
KU46_RS01640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KU46_RS01710	COG3311	Transcriptional regulator
KU46_RS01730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KU46_RS01735	COG0149	triose-phosphate isomerase activity
KU46_RS01740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU46_RS01745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KU46_RS01760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KU46_RS01765	COG1053	succinate dehydrogenase
KU46_RS01770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KU46_RS01785	COG2223	nitrite transmembrane transporter activity
KU46_RS01795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KU46_RS01800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KU46_RS01810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KU46_RS01815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KU46_RS01820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KU46_RS01825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KU46_RS01830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KU46_RS01835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KU46_RS01860	COG0564	pseudouridine synthase activity
KU46_RS01865	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KU46_RS01875	COG0124	histidyl-tRNA synthetase
KU46_RS01880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KU46_RS01885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KU46_RS01890	COG2251	uridine kinase activity
KU46_RS01890	COG0195	Participates in both transcription termination and antitermination
KU46_RS01895	COG0779	Required for maturation of 30S ribosomal subunits
KU46_RS01905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KU46_RS01910	COG0606	chelatase, subunit chli
KU46_RS01935	COG0713	ATP synthesis coupled electron transport
KU46_RS01940	COG0839	Belongs to the complex I subunit 6 family
KU46_RS01945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KU46_RS01950	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KU46_RS01955	COG1034	ATP synthesis coupled electron transport
KU46_RS01965	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KU46_RS01970	COG0649	NAD binding
KU46_RS01975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KU46_RS01980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KU46_RS01985	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KU46_RS01995	COG0527	aspartate kinase activity
KU46_RS02005	COG0076	glutamate decarboxylase activity
KU46_RS02030	COG2814	Major facilitator Superfamily
KU46_RS02040	COG3240	lipase activity
KU46_RS02055	COG0154	amidase activity
KU46_RS02060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KU46_RS02075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KU46_RS02110	COG0047	phosphoribosylformylglycinamidine synthase activity
KU46_RS02110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KU46_RS02115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KU46_RS02120	COG0076	glutamate decarboxylase activity
KU46_RS02130	COG1538	Outer membrane efflux protein
KU46_RS02145	COG0826	peptidase U32
KU46_RS02155	COG2814	Major facilitator Superfamily
KU46_RS02160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KU46_RS02165	COG4178	(ABC) transporter
KU46_RS02170	COG0531	amino acid
KU46_RS02175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KU46_RS02180	COG0814	amino acid
KU46_RS02195	COG2205	protein histidine kinase activity
KU46_RS02200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KU46_RS02210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KU46_RS02215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KU46_RS02220	COG2271	Major facilitator Superfamily
KU46_RS02250	COG0436	Aminotransferase
KU46_RS02260	COG2171	N-acyltransferase activity
KU46_RS02265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU46_RS02270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KU46_RS02275	COG0527	aspartate kinase activity
KU46_RS02285	COG0084	hydrolase, TatD family'
KU46_RS02290	COG3201	nicotinamide mononucleotide transporter
KU46_RS02315	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KU46_RS02320	COG0133	tryptophan synthase activity
KU46_RS02330	COG3201	nicotinamide mononucleotide transporter
KU46_RS02335	COG0542	response to heat
KU46_RS02355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KU46_RS02365	COG0204	Acyl-transferase
KU46_RS02405	COG0545	Peptidyl-prolyl cis-trans isomerase
KU46_RS02415	COG0375	protein maturation
KU46_RS02440	COG0531	amino acid
KU46_RS02455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KU46_RS02460	COG1530	ribonuclease E activity
KU46_RS02480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KU46_RS02485	COG0512	Glutamine amidotransferase of anthranilate synthase
KU46_RS02490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KU46_RS02495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KU46_RS02505	COG0134	indole-3-glycerol-phosphate synthase activity
KU46_RS02505	COG0135	phosphoribosylanthranilate isomerase activity
KU46_RS02510	COG0308	aminopeptidase N
KU46_RS02540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KU46_RS02555	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU46_RS02565	COG0477	Major facilitator Superfamily
KU46_RS02570	COG0488	(ABC) transporter
KU46_RS02585	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
KU46_RS02595	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
KU46_RS02615	COG0409	Hydrogenase expression formation protein
KU46_RS02620	COG0298	carbon dioxide binding
KU46_RS02625	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KU46_RS02630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KU46_RS02650	COG0814	amino acid
KU46_RS02655	COG0540	Belongs to the ATCase OTCase family
KU46_RS02660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KU46_RS02665	COG0505	Belongs to the CarA family
KU46_RS02715	COG5002	protein histidine kinase activity
KU46_RS02755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU46_RS02785	COG0284	orotidine-5'-phosphate decarboxylase activity
KU46_RS02800	COG0287	Prephenate dehydrogenase
KU46_RS02800	COG1605	Chorismate mutase
KU46_RS02805	COG1490	D-aminoacyl-tRNA deacylase activity
KU46_RS02820	COG1621	beta-fructofuranosidase activity
KU46_RS02825	COG3104	oligopeptide transport
KU46_RS02830	COG0473	3-isopropylmalate dehydrogenase activity
KU46_RS02835	COG0066	3-isopropylmalate dehydratase activity
KU46_RS02840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KU46_RS02845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KU46_RS02860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KU46_RS02860	COG0574	Belongs to the PEP-utilizing enzyme family
KU46_RS02875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KU46_RS02885	COG1560	Kdo2-lipid A biosynthetic process
KU46_RS02890	COG1560	Kdo2-lipid A biosynthetic process
KU46_RS02895	COG0706	membrane insertase activity
KU46_RS02920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KU46_RS02925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KU46_RS02930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KU46_RS02955	COG0589	response to stress
KU46_RS02975	COG1984	allophanate hydrolase subunit 2
KU46_RS02980	COG2194	sulfuric ester hydrolase activity
KU46_RS02985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KU46_RS03035	COG0814	amino acid
KU46_RS03040	COG0357	Ribosomal RNA small subunit methyltransferase G
KU46_RS03045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KU46_RS03070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KU46_RS03075	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KU46_RS03090	COG0268	Binds directly to 16S ribosomal RNA
KU46_RS03095	COG0481	GTPase activity
KU46_RS03100	COG0482	sulfurtransferase activity
KU46_RS03110	COG0242	peptide deformylase activity
KU46_RS03120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KU46_RS03120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KU46_RS03130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KU46_RS03130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KU46_RS03140	COG3961	Belongs to the TPP enzyme family
KU46_RS03175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KU46_RS03185	COG0629	single-stranded DNA binding
KU46_RS03195	COG0280	phosphate acetyltransferase
KU46_RS03195	COG0857	belongs to the CobB CobQ family
KU46_RS03200	COG1012	belongs to the aldehyde dehydrogenase family
KU46_RS03210	COG2271	Major facilitator Superfamily
KU46_RS03215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KU46_RS03215	COG3153	acetyltransferase
KU46_RS03220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KU46_RS03230	COG0557	exoribonuclease II activity
KU46_RS03240	COG0181	hydroxymethylbilane synthase activity
KU46_RS03245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KU46_RS03265	COG1116	anion transmembrane transporter activity
KU46_RS03295	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KU46_RS03305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KU46_RS03330	COG1176	ABC-type spermidine putrescine transport system, permease component I
KU46_RS03335	COG0456	acetyltransferase
KU46_RS03340	COG4067	protein conserved in archaea
KU46_RS03340	COG0189	ligase activity
KU46_RS03345	COG0658	competence protein
KU46_RS03345	COG2333	competence protein COMEC
KU46_RS03360	COG0204	Acyl-transferase
KU46_RS03380	COG0590	tRNA wobble adenosine to inosine editing
KU46_RS03385	COG1181	Belongs to the D-alanine--D-alanine ligase family
KU46_RS03390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KU46_RS03410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KU46_RS03425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KU46_RS03435	COG2862	Uncharacterized protein family, UPF0114
KU46_RS03440	COG2066	Belongs to the glutaminase family
KU46_RS03455	COG3040	lipid binding
KU46_RS03460	COG0814	amino acid
KU46_RS03465	COG0138	bifunctional purine biosynthesis protein purh
KU46_RS03470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KU46_RS03515	COG1295	ribonuclease BN
KU46_RS03525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KU46_RS03530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU46_RS03535	COG1294	oxidase, subunit
KU46_RS03540	COG1271	oxidase subunit
KU46_RS03555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KU46_RS03565	COG0714	Associated with various cellular activities
KU46_RS03585	COG2304	oxidoreductase activity
KU46_RS03600	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KU46_RS03620	COG0525	valine-tRNA ligase activity
KU46_RS03640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KU46_RS03660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KU46_RS03665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KU46_RS03675	COG0778	Nitroreductase
KU46_RS03685	COG0114	fumarate hydratase activity
KU46_RS03690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KU46_RS03705	COG1045	serine acetyltransferase
KU46_RS03710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KU46_RS03715	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KU46_RS03720	COG0052	Belongs to the universal ribosomal protein uS2 family
KU46_RS03725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KU46_RS03735	COG0233	cytoplasmic translational termination
KU46_RS03740	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KU46_RS03745	COG0575	Belongs to the CDS family
KU46_RS03750	COG0756	dUTP diphosphatase activity
KU46_RS03755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KU46_RS03760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KU46_RS03765	COG0049	tRNA binding
KU46_RS03770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KU46_RS03780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KU46_RS03785	COG0088	Forms part of the polypeptide exit tunnel
KU46_RS03790	COG0089	rRNA binding
KU46_RS03795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KU46_RS03800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KU46_RS03805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KU46_RS03815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KU46_RS03820	COG0255	Belongs to the universal ribosomal protein uL29 family
KU46_RS03825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KU46_RS03830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KU46_RS03835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KU46_RS03840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KU46_RS03845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KU46_RS03850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KU46_RS03855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KU46_RS03860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KU46_RS03870	COG1841	ribosomal large subunit assembly
KU46_RS03875	COG0200	Binds to the 23S rRNA
KU46_RS03880	COG0201	protein transport
KU46_RS03890	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KU46_RS03895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KU46_RS03900	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KU46_RS03910	COG0203	ribosomal protein L17
KU46_RS03915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KU46_RS03920	COG0326	Molecular chaperone. Has ATPase activity
KU46_RS03925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KU46_RS03930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KU46_RS03935	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KU46_RS03950	COG1438	arginine binding
KU46_RS03955	COG0165	Argininosuccinate lyase
KU46_RS03960	COG0137	argininosuccinate synthase activity
KU46_RS03965	COG1288	antiporter activity
KU46_RS03970	COG0504	CTP synthase activity
KU46_RS03975	COG0105	UTP biosynthetic process
KU46_RS03980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KU46_RS03985	COG0285	dihydrofolate synthase activity
KU46_RS03990	COG0802	atpase or kinase
KU46_RS04005	COG2918	glutathione biosynthetic process
KU46_RS04040	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KU46_RS04050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KU46_RS04070	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KU46_RS04075	COG1674	ftsk spoiiie
KU46_RS04085	COG0833	amino acid
KU46_RS04090	COG2945	thiolester hydrolase activity
KU46_RS04095	COG1494	fructose-1,6-bisphosphatase
KU46_RS04100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KU46_RS04110	COG1253	flavin adenine dinucleotide binding
KU46_RS04150	COG0215	cysteine-tRNA ligase activity
KU46_RS04155	COG2890	protein-(glutamine-N5) methyltransferase activity
KU46_RS04160	COG2814	Major facilitator Superfamily
KU46_RS04175	COG3328	transposase activity
KU46_RS04180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KU46_RS04200	COG0531	amino acid
KU46_RS04215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KU46_RS04240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KU46_RS04245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KU46_RS04250	COG1127	ABC transporter
KU46_RS04255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KU46_RS04265	COG0850	regulation of cytokinetic process
KU46_RS04270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KU46_RS04275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KU46_RS04285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KU46_RS04295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KU46_RS04305	COG0346	lactoylglutathione lyase activity
KU46_RS04310	COG1051	belongs to the nudix hydrolase family
KU46_RS04315	COG2095	MarC family integral membrane protein
KU46_RS04330	COG2252	PERMEase
KU46_RS04340	COG2985	domain, Protein
KU46_RS04345	COG0758	DNA mediated transformation
KU46_RS04355	COG2885	chlorophyll binding
KU46_RS04355	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KU46_RS04365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KU46_RS04370	COG4401	Chorismate mutase type I
KU46_RS04415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KU46_RS04430	COG0415	Belongs to the DNA photolyase family
KU46_RS04435	COG3046	protein related to deoxyribodipyrimidine photolyase
KU46_RS04440	COG0385	Bile acid
KU46_RS04475	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KU46_RS04485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KU46_RS04505	COG0501	Belongs to the peptidase M48B family
KU46_RS04510	COG1704	LemA family
KU46_RS04515	COG0583	DNA-binding transcription factor activity
KU46_RS04540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KU46_RS04580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KU46_RS04580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KU46_RS04600	COG0833	amino acid
KU46_RS04605	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KU46_RS04605	COG0662	Cupin 2, conserved barrel domain protein
KU46_RS04610	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KU46_RS04615	COG0436	Aminotransferase
KU46_RS04620	COG0497	DNA recombination
KU46_RS04640	COG0671	phosphoesterase, PA-phosphatase related
KU46_RS04645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KU46_RS04650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KU46_RS04660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KU46_RS04675	COG0792	nuclease activity
KU46_RS04680	COG0339	signal peptide processing
KU46_RS04720	COG1192	Involved in chromosome partitioning
KU46_RS04725	COG1475	DNA binding
KU46_RS04730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KU46_RS04730	COG0519	Catalyzes the synthesis of GMP from XMP
KU46_RS04740	COG2207	Transcriptional regulator
KU46_RS04745	COG2807	transmembrane transport
KU46_RS04750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KU46_RS04765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KU46_RS04770	COG0196	riboflavin kinase activity
KU46_RS04775	COG0281	malic enzyme
KU46_RS04790	COG1160	GTP binding
KU46_RS04795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KU46_RS04800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KU46_RS04810	COG4106	trans-aconitate 2-methyltransferase activity
KU46_RS04815	COG1040	competence protein
KU46_RS04820	COG0537	adenosine 5'-monophosphoramidase activity
KU46_RS04825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KU46_RS04835	COG2226	methyltransferase
KU46_RS04840	COG0837	glucose binding
KU46_RS04855	COG0009	L-threonylcarbamoyladenylate synthase
KU46_RS04860	COG1739	Uncharacterized protein family UPF0029
KU46_RS04865	COG2271	Major facilitator Superfamily
KU46_RS04930	COG1994	Peptidase M50
KU46_RS04940	COG0688	phosphatidylethanolamine metabolic process
KU46_RS04950	COG1056	cytidyltransferase-related domain
KU46_RS04950	COG1051	belongs to the nudix hydrolase family
KU46_RS04955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KU46_RS04960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KU46_RS04985	COG0024	Methionine aminopeptidase
KU46_RS05000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KU46_RS05005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KU46_RS05010	COG0739	heme binding
KU46_RS05010	COG1196	nuclear chromosome segregation
KU46_RS05010	COG0741	lytic transglycosylase activity
KU46_RS05015	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KU46_RS05025	COG0668	transmembrane transport
KU46_RS05035	COG0668	transmembrane transport
KU46_RS05040	COG0587	DNA-directed DNA polymerase activity
KU46_RS05050	COG0814	amino acid
KU46_RS05055	COG2755	lipolytic protein G-D-S-L family
KU46_RS05055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KU46_RS05060	COG0242	peptide deformylase activity
KU46_RS05080	COG1982	Orn Lys Arg decarboxylase major
KU46_RS05085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KU46_RS05090	COG0509	glycine decarboxylation via glycine cleavage system
KU46_RS05095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KU46_RS05100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KU46_RS05145	COG1523	belongs to the glycosyl hydrolase 13 family
KU46_RS05150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KU46_RS05155	COG0033	Phosphoglucomutase
KU46_RS05160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KU46_RS05165	COG0297	glycogen (starch) synthase activity
KU46_RS05175	COG0058	SHG alpha-glucan phosphorylase activity
KU46_RS05180	COG1640	4-alpha-glucanotransferase
KU46_RS05190	COG0752	glycyl-tRNA synthetase alpha subunit
KU46_RS05210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KU46_RS05220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KU46_RS05225	COG0527	aspartate kinase activity
KU46_RS05225	COG0460	homoserine dehydrogenase
KU46_RS05235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KU46_RS05255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KU46_RS05265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KU46_RS05270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KU46_RS05275	COG2814	Major facilitator Superfamily
KU46_RS05290	COG0488	(ABC) transporter
KU46_RS05295	COG3104	oligopeptide transport
KU46_RS05300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KU46_RS05305	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KU46_RS05310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KU46_RS05315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KU46_RS05320	COG0772	Belongs to the SEDS family
KU46_RS05325	COG3394	polysaccharide catabolic process
KU46_RS05330	COG0463	Glycosyl transferase, family 2
KU46_RS05335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KU46_RS05340	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KU46_RS05345	COG2920	part of a sulfur-relay system
KU46_RS05350	COG0625	glutathione transferase activity
KU46_RS05355	COG0616	signal peptide processing
KU46_RS05360	COG0470	DNA polymerase III
KU46_RS05370	COG0113	porphobilinogen synthase activity
KU46_RS05375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KU46_RS05380	COG0252	asparaginase activity
KU46_RS05385	COG3104	oligopeptide transport
KU46_RS05400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KU46_RS05405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KU46_RS05410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KU46_RS05415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KU46_RS05425	COG0439	Biotin carboxylase
KU46_RS05435	COG0668	transmembrane transport
KU46_RS05440	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KU46_RS05445	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KU46_RS05445	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KU46_RS05450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KU46_RS05460	COG0531	amino acid
KU46_RS05470	COG1162	GTPase activity
KU46_RS05485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KU46_RS05495	COG0492	ferredoxin-NADP+ reductase activity
KU46_RS05500	COG0546	phosphoglycolate phosphatase activity
KU46_RS05520	COG1446	asparaginase
KU46_RS05525	COG3104	oligopeptide transport
KU46_RS05535	COG0628	permease
KU46_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
KU46_RS05555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KU46_RS05560	COG0045	succinate-CoA ligase (ADP-forming) activity
KU46_RS05575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KU46_RS05590	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KU46_RS05595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KU46_RS05600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KU46_RS05605	COG0318	PFAM AMP-dependent synthetase and ligase
KU46_RS05605	COG0204	Acyl-transferase
KU46_RS05610	COG0275	rRNA processing
KU46_RS05615	COG3116	cell division
KU46_RS05625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KU46_RS05630	COG1185	polyribonucleotide nucleotidyltransferase activity
KU46_RS05635	COG0316	Belongs to the HesB IscA family
KU46_RS05640	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KU46_RS05645	COG0572	uridine kinase
KU46_RS05650	COG1758	RNA polymerase activity
KU46_RS05695	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KU46_RS05700	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KU46_RS05705	COG0814	amino acid
KU46_RS05710	COG1063	alcohol dehydrogenase
KU46_RS05715	COG0156	8-amino-7-oxononanoate synthase activity
KU46_RS05725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KU46_RS05730	COG0788	formyltetrahydrofolate deformylase activity
KU46_RS05755	COG0534	Mate efflux family protein
KU46_RS05765	COG0477	Major facilitator Superfamily
KU46_RS05770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KU46_RS05775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KU46_RS05785	COG2271	Major facilitator Superfamily
KU46_RS05790	COG0584	glycerophosphoryl diester phosphodiesterase
KU46_RS05800	COG1131	(ABC) transporter
KU46_RS05815	COG0659	secondary active sulfate transmembrane transporter activity
KU46_RS05820	COG0251	oxidation-reduction process
KU46_RS05835	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KU46_RS05880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KU46_RS05885	COG4988	ABC transporter
KU46_RS05910	COG1940	carbohydrate kinase activity
KU46_RS05915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KU46_RS05920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KU46_RS05925	COG0247	lactate metabolic process
KU46_RS05925	COG0277	FAD linked oxidase domain protein
KU46_RS05940	COG0295	cytidine deaminase activity
KU46_RS05945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KU46_RS05955	COG2860	membrane
KU46_RS05960	COG0742	ribosomal rna small subunit methyltransferase
KU46_RS05970	COG0612	Peptidase, M16
KU46_RS05975	COG0795	lipopolysaccharide-transporting ATPase activity
KU46_RS05980	COG0795	lipopolysaccharide-transporting ATPase activity
KU46_RS05985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KU46_RS05990	COG0516	GMP reductase activity
KU46_RS05990	COG0517	IMP dehydrogenase activity
KU46_RS06000	COG0166	Belongs to the GPI family
KU46_RS06010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KU46_RS06025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KU46_RS06030	COG0813	purine-nucleoside phosphorylase activity
KU46_RS06045	COG0653	protein targeting
KU46_RS06055	COG2818	Glycosylase
KU46_RS06060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KU46_RS06065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KU46_RS06070	COG1280	lysine exporter protein (LysE YggA)
KU46_RS06075	COG1177	transmembrane transport
KU46_RS06080	COG1176	ABC-type spermidine putrescine transport system, permease component I
KU46_RS06085	COG3842	ATPase activity
KU46_RS06110	COG0560	Phosphoserine phosphatase
KU46_RS06130	COG3104	oligopeptide transport
KU46_RS06135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KU46_RS06140	COG0531	amino acid
KU46_RS06145	COG0077	Prephenate dehydratase
KU46_RS06145	COG1605	Chorismate mutase
KU46_RS06160	COG1760	l-serine dehydratase
KU46_RS06165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KU46_RS06175	COG2151	metal-sulfur cluster biosynthetic enzyme
KU46_RS06180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KU46_RS06185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KU46_RS06205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KU46_RS06210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KU46_RS06215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KU46_RS06220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KU46_RS06225	COG0509	glycine decarboxylation via glycine cleavage system
KU46_RS06235	COG3397	chitin binding
KU46_RS06240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KU46_RS06245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KU46_RS06255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KU46_RS06275	COG1741	Belongs to the pirin family
KU46_RS06280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KU46_RS06295	COG0445	tRNA wobble uridine modification
KU46_RS06315	COG4221	oxidoreductase activity
KU46_RS06320	COG2925	Exonuclease
KU46_RS06325	COG0556	nucleotide-excision repair
KU46_RS06340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KU46_RS06360	COG0352	thiamine-phosphate diphosphorylase activity
KU46_RS06365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KU46_RS06375	COG0477	Major facilitator Superfamily
KU46_RS06380	COG0477	Major facilitator Superfamily
KU46_RS06395	COG2308	Evidence 4 Homologs of previously reported genes of
KU46_RS06415	COG1473	amidohydrolase
KU46_RS06445	COG0477	Major facilitator Superfamily
KU46_RS06455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KU46_RS06460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KU46_RS06465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KU46_RS06470	COG0131	Imidazoleglycerol-phosphate dehydratase
KU46_RS06470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KU46_RS06480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KU46_RS06485	COG0107	imidazoleglycerol-phosphate synthase activity
KU46_RS06490	COG0140	phosphoribosyl-ATP diphosphatase activity
KU46_RS06490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KU46_RS06510	COG0037	tRNA processing
KU46_RS06515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KU46_RS06520	COG2867	negative regulation of translational initiation
KU46_RS06525	COG2914	Belongs to the UPF0125 (RnfH) family
KU46_RS06530	COG1943	Transposase
KU46_RS06535	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KU46_RS06535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU46_RS06540	COG2853	Lipoprotein
KU46_RS06545	COG0405	Gamma-glutamyltransferase
KU46_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
KU46_RS06555	COG1217	gtp-binding protein TYPA
KU46_RS06575	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KU46_RS06590	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KU46_RS06595	COG1823	symporter activity
KU46_RS06600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KU46_RS06605	COG2814	Major facilitator Superfamily
KU46_RS06635	COG1496	oxidoreductase activity
KU46_RS06665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KU46_RS06670	COG4535	Mg2 and Co2 transporter CorC
KU46_RS06675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KU46_RS06680	COG1702	phosphate starvation-inducible protein PhoH
KU46_RS06685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KU46_RS06690	COG4122	O-methyltransferase activity
KU46_RS06705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KU46_RS06710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KU46_RS06715	COG1214	PFAM Peptidase M22, glycoprotease
KU46_RS06725	COG0436	Aminotransferase
KU46_RS06730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KU46_RS06745	COG0563	adenylate kinase activity
KU46_RS06775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KU46_RS06795	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KU46_RS06805	COG0531	amino acid
KU46_RS06810	COG2814	Major facilitator Superfamily
KU46_RS06815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KU46_RS06830	COG0415	Belongs to the DNA photolyase family
KU46_RS06850	COG2264	protein methyltransferase activity
KU46_RS06855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KU46_RS06940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KU46_RS06945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KU46_RS06950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU46_RS06990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KU46_RS06995	COG0084	hydrolase, TatD family'
KU46_RS07000	COG0751	glycine-tRNA ligase activity
KU46_RS07010	COG2814	Major facilitator Superfamily
KU46_RS07015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KU46_RS07020	COG0322	excinuclease ABC activity
KU46_RS07030	COG0301	tRNA thio-modification
KU46_RS07035	COG2835	tetraacyldisaccharide 4'-kinase activity
KU46_RS07040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KU46_RS07060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KU46_RS07065	COG1085	galactose-1-phosphate uridylyltransferase
KU46_RS07070	COG2814	Major facilitator Superfamily
KU46_RS07080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KU46_RS07085	COG0513	Belongs to the DEAD box helicase family
KU46_RS07095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KU46_RS07105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KU46_RS07125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KU46_RS07130	COG0408	coproporphyrinogen oxidase activity
KU46_RS07135	COG1054	Belongs to the UPF0176 family
KU46_RS07155	COG1396	sequence-specific DNA binding
KU46_RS07195	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
KU46_RS07205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KU46_RS07210	COG1061	Type III restriction enzyme res subunit
KU46_RS07230	COG1002	Type II restriction enzyme, methylase subunits
KU46_RS07245	COG0582	viral genome integration into host DNA
KU46_RS07255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KU46_RS07255	COG0116	Belongs to the methyltransferase superfamily
KU46_RS07260	COG2076	Multidrug Resistance protein
KU46_RS07265	COG0798	PFAM Bile acid sodium symporter
KU46_RS07270	COG0640	Transcriptional regulator
KU46_RS07285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KU46_RS07290	COG0189	ligase activity
KU46_RS07295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KU46_RS07305	COG1959	2 iron, 2 sulfur cluster binding
KU46_RS07310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU46_RS07310	COG1017	nitric oxide dioxygenase activity
KU46_RS07315	COG1472	Belongs to the glycosyl hydrolase 3 family
KU46_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
KU46_RS07335	COG1940	carbohydrate kinase activity
KU46_RS07345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KU46_RS07350	COG4106	trans-aconitate 2-methyltransferase activity
KU46_RS07355	COG0156	8-amino-7-oxononanoate synthase activity
KU46_RS07360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KU46_RS07365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KU46_RS07380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KU46_RS07380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KU46_RS07390	COG0318	PFAM AMP-dependent synthetase and ligase
KU46_RS07395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KU46_RS07395	COG0512	Glutamine amidotransferase of anthranilate synthase
KU46_RS07400	COG0512	Glutamine amidotransferase of anthranilate synthase
KU46_RS07400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KU46_RS07410	COG0667	Aldo Keto reductase
KU46_RS07415	COG0667	Aldo Keto reductase
KU46_RS07420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KU46_RS07420	COG3153	acetyltransferase
KU46_RS07435	COG0302	gtp cyclohydrolase
KU46_RS07440	COG0513	Belongs to the DEAD box helicase family
KU46_RS07445	COG3104	oligopeptide transport
KU46_RS07450	COG0393	Putative heavy-metal-binding
KU46_RS07455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU46_RS07475	COG0708	Exodeoxyribonuclease III
KU46_RS07485	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU46_RS07500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KU46_RS07505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KU46_RS07530	COG0531	amino acid
KU46_RS07535	COG0569	domain protein
KU46_RS07545	COG0719	Fe-S assembly protein
KU46_RS07550	COG0396	ATPase activity
KU46_RS07555	COG0719	Fe-S assembly protein
KU46_RS07575	COG0833	amino acid
KU46_RS07585	COG0494	nUDIX hydrolase
KU46_RS07590	COG1678	Uncharacterized ACR, COG1678
KU46_RS07595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KU46_RS07600	COG0495	leucyl-tRNA aminoacylation
KU46_RS07620	COG4969	Belongs to the N-Me-Phe pilin family
KU46_RS07625	COG0659	secondary active sulfate transmembrane transporter activity
KU46_RS07660	COG0717	Belongs to the dCTP deaminase family
KU46_RS07665	COG0489	protein tyrosine kinase activity
KU46_RS07680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KU46_RS07695	COG0523	cobalamin synthesis protein
KU46_RS07700	COG0735	belongs to the Fur family
KU46_RS07705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU46_RS07705	COG0072	phenylalanine-tRNA ligase activity
KU46_RS07710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KU46_RS07715	COG0697	spore germination
KU46_RS07720	COG3104	oligopeptide transport
KU46_RS07740	COG3655	Transcriptional regulator
KU46_RS07750	COG2255	four-way junction helicase activity
KU46_RS07765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KU46_RS07770	COG0519	Catalyzes the synthesis of GMP from XMP
KU46_RS07770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KU46_RS07775	COG0101	tRNA pseudouridine synthase activity
KU46_RS07780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KU46_RS07790	COG1137	ATPase activity
KU46_RS07805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KU46_RS07810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KU46_RS07815	COG1686	Belongs to the peptidase S11 family
KU46_RS07820	COG2921	Belongs to the UPF0250 family
KU46_RS07845	COG1610	YqeY-like protein
KU46_RS07870	COG0037	tRNA processing
KU46_RS07880	COG0142	geranyltranstransferase activity
KU46_RS07905	COG1187	pseudouridine synthase activity
KU46_RS07915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KU46_RS07925	COG0359	binds to the 23S rRNA
KU46_RS07930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KU46_RS07935	COG0360	Binds together with S18 to 16S ribosomal RNA
KU46_RS07940	COG0450	alkyl hydroperoxide reductase
KU46_RS07945	COG2996	Protein conserved in bacteria
KU46_RS07950	COG0210	DNA helicase
KU46_RS07955	COG0354	folic acid binding
KU46_RS07970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KU46_RS07980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KU46_RS07990	COG0210	DNA helicase
KU46_RS08000	COG0799	negative regulation of ribosome biogenesis
KU46_RS08020	COG2814	Major facilitator Superfamily
KU46_RS08025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KU46_RS08030	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KU46_RS08035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU46_RS08040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KU46_RS08065	COG0535	radical SAM domain protein
KU46_RS08080	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
KU46_RS08100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KU46_RS08100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KU46_RS08115	COG4948	Mandelate Racemase Muconate Lactonizing
KU46_RS08125	COG0386	Belongs to the glutathione peroxidase family
KU46_RS08135	COG0753	catalase activity
KU46_RS08150	COG0583	DNA-binding transcription factor activity
KU46_RS08155	COG2132	Multicopper oxidase
KU46_RS08160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KU46_RS08165	COG1937	Protein conserved in bacteria
KU46_RS08175	COG1012	belongs to the aldehyde dehydrogenase family
KU46_RS08190	COG1876	peptidase activity
KU46_RS08210	COG2824	Alkylphosphonate utilization operon protein PhnA
KU46_RS08220	COG0450	alkyl hydroperoxide reductase
KU46_RS08235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KU46_RS08245	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KU46_RS08255	COG0039	L-malate dehydrogenase activity
KU46_RS08265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KU46_RS08275	COG0488	(ABC) transporter
KU46_RS08290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KU46_RS08305	COG1278	Cold shock
KU46_RS08310	COG0686	Belongs to the AlaDH PNT family
KU46_RS08320	COG1509	lysine 2,3-aminomutase activity
KU46_RS08335	COG1566	PFAM secretion protein HlyD family protein
KU46_RS08350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KU46_RS08370	COG3961	Belongs to the TPP enzyme family
KU46_RS08380	COG0583	DNA-binding transcription factor activity
KU46_RS08385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KU46_RS08390	COG0095	Lipoate-protein ligase
KU46_RS08400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KU46_RS08405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KU46_RS08410	COG3104	oligopeptide transport
KU46_RS08415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU46_RS08420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU46_RS08425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KU46_RS08440	COG0193	aminoacyl-tRNA hydrolase activity
KU46_RS08445	COG0012	GTP binding
KU46_RS08455	COG4536	flavin adenine dinucleotide binding
KU46_RS08460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KU46_RS08465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KU46_RS08510	COG1322	Protein conserved in bacteria
KU46_RS08520	COG2271	Major facilitator Superfamily
KU46_RS08525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KU46_RS08530	COG0217	transcriptional regulatory protein
KU46_RS08535	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KU46_RS08540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KU46_RS08545	COG1528	Iron-storage protein
KU46_RS08550	COG3104	oligopeptide transport
KU46_RS08565	COG2999	glutathione oxidoreductase activity
KU46_RS08570	COG2878	Part of a membrane complex involved in electron transport
KU46_RS08575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KU46_RS08595	COG0670	Belongs to the BI1 family
KU46_RS08600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KU46_RS08605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KU46_RS08615	COG0028	Belongs to the TPP enzyme family
KU46_RS08620	COG0129	dihydroxy-acid dehydratase activity
KU46_RS08630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KU46_RS08635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KU46_RS08640	COG0330	HflC and HflK could
KU46_RS08645	COG0330	HflC and HflK could
KU46_RS08655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KU46_RS08660	COG1923	regulation of RNA biosynthetic process
KU46_RS08665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KU46_RS08680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KU46_RS08685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KU46_RS08690	COG0740	serine-type endopeptidase activity
KU46_RS08695	COG0544	peptidyl-prolyl cis-trans isomerase activity
KU46_RS08705	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KU46_RS08720	COG1943	Transposase
KU46_RS08725	COG0732	type I restriction modification DNA specificity domain
KU46_RS08750	COG0288	reversible hydration of carbon dioxide
KU46_RS08755	COG0252	asparaginase activity
KU46_RS08760	COG0328	RNA-DNA hybrid ribonuclease activity
KU46_RS08775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KU46_RS08785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KU46_RS08790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KU46_RS08795	COG1862	Preprotein translocase
KU46_RS08800	COG3387	PFAM Glycoside hydrolase 15-related
KU46_RS08810	COG1335	isochorismatase
KU46_RS08830	COG0583	DNA-binding transcription factor activity
KU46_RS08835	COG0343	queuine tRNA-ribosyltransferase activity
KU46_RS08840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KU46_RS08850	COG1464	Belongs to the NlpA lipoprotein family
KU46_RS08855	COG0814	amino acid
KU46_RS08870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KU46_RS08875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KU46_RS08880	COG1181	Belongs to the D-alanine--D-alanine ligase family
KU46_RS08880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KU46_RS08885	COG0189	ligase activity
KU46_RS08885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KU46_RS08910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KU46_RS08960	COG1446	asparaginase
KU46_RS08980	COG1215	transferase activity, transferring glycosyl groups
KU46_RS08985	COG0438	transferase activity, transferring glycosyl groups
KU46_RS08990	COG1442	glycosyl transferase family 8
KU46_RS08990	COG1216	Glycosyl transferase, family 2
KU46_RS08995	COG0463	Glycosyl transferase, family 2
KU46_RS09005	COG1216	Glycosyl transferase, family 2
KU46_RS09005	COG1442	glycosyl transferase family 8
KU46_RS09015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KU46_RS09015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KU46_RS09020	COG0367	asparagine synthase
KU46_RS09025	COG1132	(ABC) transporter
KU46_RS09030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KU46_RS09035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KU46_RS09040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KU46_RS09045	COG0517	IMP dehydrogenase activity
KU46_RS09045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KU46_RS09060	COG3220	belongs to the UPF0276 family
KU46_RS09080	COG1611	Belongs to the LOG family
KU46_RS09090	COG2226	methyltransferase
KU46_RS09100	COG0346	lactoylglutathione lyase activity
KU46_RS09105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KU46_RS09125	COG0561	phosphatase activity
KU46_RS09140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KU46_RS09155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU46_RS09160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU46_RS09165	COG3079	Belongs to the UPF0149 family
KU46_RS09180	COG0586	Pfam SNARE associated Golgi protein
KU46_RS09185	COG0586	Pfam SNARE associated Golgi protein
KU46_RS09190	COG1381	Involved in DNA repair and RecF pathway recombination
KU46_RS09200	COG1104	cysteine desulfurase activity
KU46_RS09205	COG1530	ribonuclease E activity
KU46_RS09210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KU46_RS09215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KU46_RS09220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KU46_RS09225	COG0037	tRNA processing
KU46_RS09255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KU46_RS09265	COG0277	FAD linked oxidase domain protein
KU46_RS09265	COG0277	FAD linked oxidase domain protein
KU46_RS09270	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KU46_RS09275	COG0564	pseudouridine synthase activity
KU46_RS09285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KU46_RS09290	COG1127	ABC transporter
KU46_RS09310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KU46_RS09330	COG0477	Major facilitator Superfamily
KU46_RS09345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KU46_RS09355	COG0484	heat shock protein binding
KU46_RS09360	COG0443	Heat shock 70 kDa protein
KU46_RS09365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KU46_RS09370	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KU46_RS09380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KU46_RS09385	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KU46_RS09415	COG1846	Transcriptional regulator
KU46_RS09435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KU46_RS09460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KU46_RS09470	COG0583	DNA-binding transcription factor activity
KU46_RS09610	COG0191	fructose-bisphosphate aldolase activity
KU46_RS09615	COG0469	pyruvate kinase activity
KU46_RS09620	COG0126	phosphoglycerate kinase activity
KU46_RS09635	COG1399	metal-binding, possibly nucleic acid-binding protein
KU46_RS09640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KU46_RS09645	COG0416	fatty acid biosynthetic process
KU46_RS09655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KU46_RS09660	COG1028	Short-chain dehydrogenase reductase Sdr
KU46_RS09665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU46_RS09670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KU46_RS09680	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KU46_RS09680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU46_RS09690	COG2855	membrane
KU46_RS09695	COG0483	inositol monophosphate 1-phosphatase activity
KU46_RS09715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KU46_RS09730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KU46_RS09745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KU46_RS09750	COG1074	ATP-dependent DNA helicase activity
KU46_RS09755	COG0028	Belongs to the TPP enzyme family
KU46_RS09780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KU46_RS09790	COG0069	glutamate synthase activity
KU46_RS09810	COG0500	methyltransferase
KU46_RS09845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU46_RS09865	COG2166	iron-sulfur cluster assembly
KU46_RS09880	COG0442	prolyl-tRNA aminoacylation
KU46_RS09930	COG0732	type I restriction modification DNA specificity domain
KU46_RS09955	COG0277	FAD linked oxidase domain protein
KU46_RS09960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC