locus-tag	class	description
FPHI_RS00010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FPHI_RS00040	COG0563	adenylate kinase activity
FPHI_RS00055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FPHI_RS00060	COG0436	Aminotransferase
FPHI_RS00070	COG1214	PFAM Peptidase M22, glycoprotease
FPHI_RS00075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FPHI_RS00080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FPHI_RS00095	COG4122	O-methyltransferase activity
FPHI_RS00100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPHI_RS00105	COG1702	phosphate starvation-inducible protein PhoH
FPHI_RS00110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FPHI_RS00115	COG4535	Mg2 and Co2 transporter CorC
FPHI_RS00120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FPHI_RS00150	COG1496	oxidoreductase activity
FPHI_RS00175	COG2814	Major facilitator Superfamily
FPHI_RS00180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPHI_RS00185	COG1823	symporter activity
FPHI_RS00190	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FPHI_RS00205	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FPHI_RS00225	COG1217	gtp-binding protein TYPA
FPHI_RS00230	COG1028	Short-chain dehydrogenase reductase Sdr
FPHI_RS00235	COG0405	Gamma-glutamyltransferase
FPHI_RS00240	COG2853	Lipoprotein
FPHI_RS00245	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FPHI_RS00245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPHI_RS00250	COG1943	Transposase
FPHI_RS00255	COG2914	Belongs to the UPF0125 (RnfH) family
FPHI_RS00260	COG2867	negative regulation of translational initiation
FPHI_RS00265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FPHI_RS00270	COG0037	tRNA processing
FPHI_RS00290	COG0140	phosphoribosyl-ATP diphosphatase activity
FPHI_RS00290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FPHI_RS00295	COG0107	imidazoleglycerol-phosphate synthase activity
FPHI_RS00300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FPHI_RS00310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FPHI_RS00310	COG0131	Imidazoleglycerol-phosphate dehydratase
FPHI_RS00315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FPHI_RS00320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FPHI_RS00325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FPHI_RS00335	COG0477	Major facilitator Superfamily
FPHI_RS00365	COG1473	amidohydrolase
FPHI_RS00385	COG2308	Evidence 4 Homologs of previously reported genes of
FPHI_RS00400	COG0477	Major facilitator Superfamily
FPHI_RS00405	COG0477	Major facilitator Superfamily
FPHI_RS00415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FPHI_RS00420	COG0352	thiamine-phosphate diphosphorylase activity
FPHI_RS00440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FPHI_RS00455	COG0556	nucleotide-excision repair
FPHI_RS00460	COG2925	Exonuclease
FPHI_RS00465	COG4221	oxidoreductase activity
FPHI_RS00485	COG0445	tRNA wobble uridine modification
FPHI_RS00500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FPHI_RS00505	COG1741	Belongs to the pirin family
FPHI_RS00525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FPHI_RS00535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FPHI_RS00540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FPHI_RS00545	COG3397	chitin binding
FPHI_RS00555	COG0509	glycine decarboxylation via glycine cleavage system
FPHI_RS00560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FPHI_RS00565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FPHI_RS00570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FPHI_RS00575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FPHI_RS00595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FPHI_RS00600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FPHI_RS00605	COG2151	metal-sulfur cluster biosynthetic enzyme
FPHI_RS00615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FPHI_RS00620	COG1760	l-serine dehydratase
FPHI_RS00635	COG1605	Chorismate mutase
FPHI_RS00635	COG0077	Prephenate dehydratase
FPHI_RS00640	COG0531	amino acid
FPHI_RS00645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FPHI_RS00650	COG3104	oligopeptide transport
FPHI_RS00670	COG0560	Phosphoserine phosphatase
FPHI_RS00695	COG3842	ATPase activity
FPHI_RS00700	COG1176	ABC-type spermidine putrescine transport system, permease component I
FPHI_RS00705	COG1177	transmembrane transport
FPHI_RS00710	COG1280	lysine exporter protein (LysE YggA)
FPHI_RS00715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FPHI_RS00720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FPHI_RS00725	COG2818	Glycosylase
FPHI_RS00735	COG0653	protein targeting
FPHI_RS00750	COG0813	purine-nucleoside phosphorylase activity
FPHI_RS00755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FPHI_RS00770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FPHI_RS00780	COG0166	Belongs to the GPI family
FPHI_RS00790	COG0516	GMP reductase activity
FPHI_RS00790	COG0517	IMP dehydrogenase activity
FPHI_RS00795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPHI_RS00800	COG0795	lipopolysaccharide-transporting ATPase activity
FPHI_RS00805	COG0795	lipopolysaccharide-transporting ATPase activity
FPHI_RS00810	COG0612	Peptidase, M16
FPHI_RS00820	COG0742	ribosomal rna small subunit methyltransferase
FPHI_RS00825	COG2860	membrane
FPHI_RS00835	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FPHI_RS00840	COG0295	cytidine deaminase activity
FPHI_RS00855	COG0277	FAD linked oxidase domain protein
FPHI_RS00855	COG0247	lactate metabolic process
FPHI_RS00860	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FPHI_RS00865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FPHI_RS00870	COG1940	carbohydrate kinase activity
FPHI_RS00895	COG4988	ABC transporter
FPHI_RS00900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FPHI_RS00950	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FPHI_RS00965	COG0251	oxidation-reduction process
FPHI_RS00970	COG0659	secondary active sulfate transmembrane transporter activity
FPHI_RS00985	COG1131	(ABC) transporter
FPHI_RS00995	COG0584	glycerophosphoryl diester phosphodiesterase
FPHI_RS01000	COG2271	Major facilitator Superfamily
FPHI_RS01010	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FPHI_RS01015	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FPHI_RS01020	COG0477	Major facilitator Superfamily
FPHI_RS01030	COG0534	Mate efflux family protein
FPHI_RS01055	COG0788	formyltetrahydrofolate deformylase activity
FPHI_RS01060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FPHI_RS01070	COG0156	8-amino-7-oxononanoate synthase activity
FPHI_RS01075	COG1063	alcohol dehydrogenase
FPHI_RS01080	COG0814	amino acid
FPHI_RS01085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FPHI_RS01090	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FPHI_RS01135	COG1758	RNA polymerase activity
FPHI_RS01140	COG0572	uridine kinase
FPHI_RS01145	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FPHI_RS01150	COG0316	Belongs to the HesB IscA family
FPHI_RS01155	COG1185	polyribonucleotide nucleotidyltransferase activity
FPHI_RS01160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FPHI_RS01170	COG3116	cell division
FPHI_RS01175	COG0275	rRNA processing
FPHI_RS01180	COG0204	Acyl-transferase
FPHI_RS01180	COG0318	PFAM AMP-dependent synthetase and ligase
FPHI_RS01185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FPHI_RS01190	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FPHI_RS01195	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FPHI_RS01210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPHI_RS01225	COG0045	succinate-CoA ligase (ADP-forming) activity
FPHI_RS01230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FPHI_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
FPHI_RS01250	COG0628	permease
FPHI_RS01260	COG3104	oligopeptide transport
FPHI_RS01265	COG1446	asparaginase
FPHI_RS01285	COG0546	phosphoglycolate phosphatase activity
FPHI_RS01290	COG0492	ferredoxin-NADP+ reductase activity
FPHI_RS01300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FPHI_RS01315	COG1162	GTPase activity
FPHI_RS01325	COG0531	amino acid
FPHI_RS01335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FPHI_RS01340	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FPHI_RS01340	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FPHI_RS01345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FPHI_RS01350	COG0668	transmembrane transport
FPHI_RS01360	COG0439	Biotin carboxylase
FPHI_RS01370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FPHI_RS01375	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FPHI_RS01380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FPHI_RS01385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPHI_RS01400	COG3104	oligopeptide transport
FPHI_RS01405	COG0252	asparaginase activity
FPHI_RS01410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FPHI_RS01415	COG0113	porphobilinogen synthase activity
FPHI_RS01425	COG0470	DNA polymerase III
FPHI_RS01430	COG0616	signal peptide processing
FPHI_RS01435	COG0625	glutathione transferase activity
FPHI_RS01440	COG2920	part of a sulfur-relay system
FPHI_RS01445	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FPHI_RS01450	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FPHI_RS01455	COG0463	Glycosyl transferase, family 2
FPHI_RS01460	COG3394	polysaccharide catabolic process
FPHI_RS01465	COG0772	Belongs to the SEDS family
FPHI_RS01470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FPHI_RS01475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FPHI_RS01480	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FPHI_RS01485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPHI_RS01490	COG3104	oligopeptide transport
FPHI_RS01495	COG0488	(ABC) transporter
FPHI_RS01510	COG2814	Major facilitator Superfamily
FPHI_RS01515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPHI_RS01520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPHI_RS01530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FPHI_RS01550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FPHI_RS01560	COG0527	aspartate kinase activity
FPHI_RS01560	COG0460	homoserine dehydrogenase
FPHI_RS01565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FPHI_RS01575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FPHI_RS01595	COG0752	glycyl-tRNA synthetase alpha subunit
FPHI_RS01605	COG1640	4-alpha-glucanotransferase
FPHI_RS01610	COG0058	SHG alpha-glucan phosphorylase activity
FPHI_RS01620	COG0297	glycogen (starch) synthase activity
FPHI_RS01625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FPHI_RS01630	COG0033	Phosphoglucomutase
FPHI_RS01635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FPHI_RS01640	COG1523	belongs to the glycosyl hydrolase 13 family
FPHI_RS01685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPHI_RS01690	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FPHI_RS01695	COG0509	glycine decarboxylation via glycine cleavage system
FPHI_RS01700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FPHI_RS01705	COG1982	Orn Lys Arg decarboxylase major
FPHI_RS01725	COG0242	peptide deformylase activity
FPHI_RS01730	COG2755	lipolytic protein G-D-S-L family
FPHI_RS01730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FPHI_RS01735	COG0814	amino acid
FPHI_RS01745	COG0587	DNA-directed DNA polymerase activity
FPHI_RS01750	COG0668	transmembrane transport
FPHI_RS01760	COG0668	transmembrane transport
FPHI_RS01770	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FPHI_RS01775	COG0741	lytic transglycosylase activity
FPHI_RS01775	COG1196	nuclear chromosome segregation
FPHI_RS01775	COG0739	heme binding
FPHI_RS01780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FPHI_RS01785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FPHI_RS01800	COG0024	Methionine aminopeptidase
FPHI_RS01825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FPHI_RS01830	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FPHI_RS01835	COG1051	belongs to the nudix hydrolase family
FPHI_RS01835	COG1056	cytidyltransferase-related domain
FPHI_RS01845	COG0688	phosphatidylethanolamine metabolic process
FPHI_RS01855	COG1994	Peptidase M50
FPHI_RS01920	COG2271	Major facilitator Superfamily
FPHI_RS01925	COG1739	Uncharacterized protein family UPF0029
FPHI_RS01930	COG0009	L-threonylcarbamoyladenylate synthase
FPHI_RS01945	COG0837	glucose binding
FPHI_RS01950	COG2226	methyltransferase
FPHI_RS01960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FPHI_RS01965	COG0537	adenosine 5'-monophosphoramidase activity
FPHI_RS01970	COG1040	competence protein
FPHI_RS01975	COG4106	trans-aconitate 2-methyltransferase activity
FPHI_RS01985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FPHI_RS01990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FPHI_RS01995	COG1160	GTP binding
FPHI_RS02010	COG0281	malic enzyme
FPHI_RS02015	COG0196	riboflavin kinase activity
FPHI_RS02020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FPHI_RS02035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FPHI_RS02040	COG2807	transmembrane transport
FPHI_RS02045	COG2207	Transcriptional regulator
FPHI_RS02055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPHI_RS02055	COG0519	Catalyzes the synthesis of GMP from XMP
FPHI_RS02060	COG1475	DNA binding
FPHI_RS02065	COG1192	Involved in chromosome partitioning
FPHI_RS02105	COG0339	signal peptide processing
FPHI_RS02110	COG0792	nuclease activity
FPHI_RS02125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FPHI_RS02135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FPHI_RS02140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FPHI_RS02145	COG0671	phosphoesterase, PA-phosphatase related
FPHI_RS02165	COG0497	DNA recombination
FPHI_RS02170	COG0436	Aminotransferase
FPHI_RS02175	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FPHI_RS02180	COG0662	Cupin 2, conserved barrel domain protein
FPHI_RS02180	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FPHI_RS02185	COG0833	amino acid
FPHI_RS02205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPHI_RS02205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPHI_RS02245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FPHI_RS02270	COG0583	DNA-binding transcription factor activity
FPHI_RS02275	COG1704	LemA family
FPHI_RS02280	COG0501	Belongs to the peptidase M48B family
FPHI_RS02300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FPHI_RS02310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FPHI_RS02345	COG0385	Bile acid
FPHI_RS02350	COG3046	protein related to deoxyribodipyrimidine photolyase
FPHI_RS02355	COG0415	Belongs to the DNA photolyase family
FPHI_RS02370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FPHI_RS02415	COG4401	Chorismate mutase type I
FPHI_RS02420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FPHI_RS02430	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FPHI_RS02430	COG2885	chlorophyll binding
FPHI_RS02440	COG0758	DNA mediated transformation
FPHI_RS02445	COG2985	domain, Protein
FPHI_RS02455	COG2252	PERMEase
FPHI_RS02470	COG2095	MarC family integral membrane protein
FPHI_RS02475	COG1051	belongs to the nudix hydrolase family
FPHI_RS02480	COG0346	lactoylglutathione lyase activity
FPHI_RS02490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FPHI_RS02500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FPHI_RS02510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FPHI_RS02515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FPHI_RS02520	COG0850	regulation of cytokinetic process
FPHI_RS02530	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FPHI_RS02535	COG1127	ABC transporter
FPHI_RS02540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPHI_RS02545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FPHI_RS02570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FPHI_RS02585	COG0531	amino acid
FPHI_RS02605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FPHI_RS02610	COG3328	transposase activity
FPHI_RS02625	COG2814	Major facilitator Superfamily
FPHI_RS02630	COG2890	protein-(glutamine-N5) methyltransferase activity
FPHI_RS02635	COG0215	cysteine-tRNA ligase activity
FPHI_RS02675	COG1253	flavin adenine dinucleotide binding
FPHI_RS02685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FPHI_RS02690	COG1494	fructose-1,6-bisphosphatase
FPHI_RS02695	COG2945	thiolester hydrolase activity
FPHI_RS02700	COG0833	amino acid
FPHI_RS02710	COG1674	ftsk spoiiie
FPHI_RS02715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FPHI_RS02735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FPHI_RS02745	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FPHI_RS02780	COG2918	glutathione biosynthetic process
FPHI_RS02795	COG0802	atpase or kinase
FPHI_RS02800	COG0285	dihydrofolate synthase activity
FPHI_RS02805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FPHI_RS02810	COG0105	UTP biosynthetic process
FPHI_RS02815	COG0504	CTP synthase activity
FPHI_RS02820	COG1288	antiporter activity
FPHI_RS02825	COG0137	argininosuccinate synthase activity
FPHI_RS02830	COG0165	Argininosuccinate lyase
FPHI_RS02835	COG1438	arginine binding
FPHI_RS02850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FPHI_RS02855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FPHI_RS02860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FPHI_RS02865	COG0326	Molecular chaperone. Has ATPase activity
FPHI_RS02870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FPHI_RS02875	COG0203	ribosomal protein L17
FPHI_RS02885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FPHI_RS02890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FPHI_RS02895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FPHI_RS02905	COG0201	protein transport
FPHI_RS02910	COG0200	Binds to the 23S rRNA
FPHI_RS02915	COG1841	ribosomal large subunit assembly
FPHI_RS02925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FPHI_RS02930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FPHI_RS02935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FPHI_RS02940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FPHI_RS02945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FPHI_RS02950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FPHI_RS02955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FPHI_RS02960	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FPHI_RS02965	COG0255	Belongs to the universal ribosomal protein uL29 family
FPHI_RS02970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FPHI_RS02980	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FPHI_RS02985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FPHI_RS02990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FPHI_RS02995	COG0089	rRNA binding
FPHI_RS03000	COG0088	Forms part of the polypeptide exit tunnel
FPHI_RS03005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FPHI_RS03015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FPHI_RS03020	COG0049	tRNA binding
FPHI_RS03025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FPHI_RS03030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FPHI_RS03035	COG0756	dUTP diphosphatase activity
FPHI_RS03040	COG0575	Belongs to the CDS family
FPHI_RS03045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FPHI_RS03050	COG0233	cytoplasmic translational termination
FPHI_RS03060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FPHI_RS03065	COG0052	Belongs to the universal ribosomal protein uS2 family
FPHI_RS03070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FPHI_RS03075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FPHI_RS03080	COG1045	serine acetyltransferase
FPHI_RS03095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FPHI_RS03100	COG0114	fumarate hydratase activity
FPHI_RS03110	COG0778	Nitroreductase
FPHI_RS03120	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FPHI_RS03125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FPHI_RS03145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FPHI_RS03165	COG0525	valine-tRNA ligase activity
FPHI_RS03185	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FPHI_RS03200	COG2304	oxidoreductase activity
FPHI_RS03220	COG0714	Associated with various cellular activities
FPHI_RS03230	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FPHI_RS03245	COG1271	oxidase subunit
FPHI_RS03250	COG1294	oxidase, subunit
FPHI_RS03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FPHI_RS03260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FPHI_RS03270	COG1295	ribonuclease BN
FPHI_RS03315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FPHI_RS03320	COG0138	bifunctional purine biosynthesis protein purh
FPHI_RS03325	COG0814	amino acid
FPHI_RS03330	COG3040	lipid binding
FPHI_RS03345	COG2066	Belongs to the glutaminase family
FPHI_RS03350	COG2862	Uncharacterized protein family, UPF0114
FPHI_RS03360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FPHI_RS03375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FPHI_RS03395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FPHI_RS03400	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPHI_RS03405	COG0590	tRNA wobble adenosine to inosine editing
FPHI_RS03415	COG0009	L-threonylcarbamoyladenylate synthase
FPHI_RS03425	COG0204	Acyl-transferase
FPHI_RS03440	COG0658	competence protein
FPHI_RS03440	COG2333	competence protein COMEC
FPHI_RS03445	COG4067	protein conserved in archaea
FPHI_RS03445	COG0189	ligase activity
FPHI_RS03450	COG0456	acetyltransferase
FPHI_RS03455	COG1176	ABC-type spermidine putrescine transport system, permease component I
FPHI_RS03480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FPHI_RS03490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FPHI_RS03520	COG1116	anion transmembrane transporter activity
FPHI_RS03540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FPHI_RS03545	COG0181	hydroxymethylbilane synthase activity
FPHI_RS03555	COG0557	exoribonuclease II activity
FPHI_RS03565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FPHI_RS03570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPHI_RS03570	COG3153	acetyltransferase
FPHI_RS03575	COG2271	Major facilitator Superfamily
FPHI_RS03585	COG1012	belongs to the aldehyde dehydrogenase family
FPHI_RS03590	COG0857	belongs to the CobB CobQ family
FPHI_RS03590	COG0280	phosphate acetyltransferase
FPHI_RS03600	COG0629	single-stranded DNA binding
FPHI_RS03610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FPHI_RS03645	COG3961	Belongs to the TPP enzyme family
FPHI_RS03655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPHI_RS03655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FPHI_RS03665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FPHI_RS03665	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FPHI_RS03675	COG0242	peptide deformylase activity
FPHI_RS03685	COG0482	sulfurtransferase activity
FPHI_RS03690	COG0481	GTPase activity
FPHI_RS03695	COG0268	Binds directly to 16S ribosomal RNA
FPHI_RS03710	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPHI_RS03715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FPHI_RS03740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FPHI_RS03745	COG0357	Ribosomal RNA small subunit methyltransferase G
FPHI_RS03750	COG0814	amino acid
FPHI_RS03800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FPHI_RS03805	COG2194	sulfuric ester hydrolase activity
FPHI_RS03810	COG1984	allophanate hydrolase subunit 2
FPHI_RS03830	COG0589	response to stress
FPHI_RS03855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FPHI_RS03860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FPHI_RS03865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FPHI_RS03890	COG0706	membrane insertase activity
FPHI_RS03895	COG1560	Kdo2-lipid A biosynthetic process
FPHI_RS03900	COG1560	Kdo2-lipid A biosynthetic process
FPHI_RS03910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FPHI_RS03925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FPHI_RS03925	COG0574	Belongs to the PEP-utilizing enzyme family
FPHI_RS03940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FPHI_RS03945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FPHI_RS03950	COG0066	3-isopropylmalate dehydratase activity
FPHI_RS03955	COG0473	3-isopropylmalate dehydrogenase activity
FPHI_RS03960	COG3104	oligopeptide transport
FPHI_RS03965	COG1621	beta-fructofuranosidase activity
FPHI_RS03980	COG1490	D-aminoacyl-tRNA deacylase activity
FPHI_RS03985	COG0287	Prephenate dehydrogenase
FPHI_RS03985	COG1605	Chorismate mutase
FPHI_RS04000	COG0284	orotidine-5'-phosphate decarboxylase activity
FPHI_RS04030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPHI_RS04070	COG5002	protein histidine kinase activity
FPHI_RS04120	COG0505	Belongs to the CarA family
FPHI_RS04125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FPHI_RS04130	COG0540	Belongs to the ATCase OTCase family
FPHI_RS04135	COG0814	amino acid
FPHI_RS04155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FPHI_RS04160	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FPHI_RS04165	COG0298	carbon dioxide binding
FPHI_RS04170	COG0409	Hydrogenase expression formation protein
FPHI_RS04190	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
FPHI_RS04200	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FPHI_RS04215	COG0488	(ABC) transporter
FPHI_RS04220	COG0477	Major facilitator Superfamily
FPHI_RS04230	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPHI_RS04245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FPHI_RS04275	COG0308	aminopeptidase N
FPHI_RS04280	COG0134	indole-3-glycerol-phosphate synthase activity
FPHI_RS04280	COG0135	phosphoribosylanthranilate isomerase activity
FPHI_RS04290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPHI_RS04295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FPHI_RS04300	COG0512	Glutamine amidotransferase of anthranilate synthase
FPHI_RS04305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FPHI_RS04325	COG1530	ribonuclease E activity
FPHI_RS04330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FPHI_RS04345	COG0531	amino acid
FPHI_RS04370	COG0375	protein maturation
FPHI_RS04380	COG0545	Peptidyl-prolyl cis-trans isomerase
FPHI_RS04420	COG0204	Acyl-transferase
FPHI_RS04430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FPHI_RS04450	COG0542	response to heat
FPHI_RS04455	COG3201	nicotinamide mononucleotide transporter
FPHI_RS04465	COG0133	tryptophan synthase activity
FPHI_RS04470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FPHI_RS04495	COG3201	nicotinamide mononucleotide transporter
FPHI_RS04500	COG0084	hydrolase, TatD family'
FPHI_RS04510	COG0527	aspartate kinase activity
FPHI_RS04515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FPHI_RS04520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FPHI_RS04525	COG2171	N-acyltransferase activity
FPHI_RS04535	COG0436	Aminotransferase
FPHI_RS04565	COG2271	Major facilitator Superfamily
FPHI_RS04570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FPHI_RS04575	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FPHI_RS04585	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FPHI_RS04590	COG2205	protein histidine kinase activity
FPHI_RS04605	COG0814	amino acid
FPHI_RS04610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FPHI_RS04615	COG0531	amino acid
FPHI_RS04620	COG4178	(ABC) transporter
FPHI_RS04625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FPHI_RS04630	COG2814	Major facilitator Superfamily
FPHI_RS04640	COG0826	peptidase U32
FPHI_RS04655	COG1538	Outer membrane efflux protein
FPHI_RS04665	COG0076	glutamate decarboxylase activity
FPHI_RS04670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FPHI_RS04675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FPHI_RS04675	COG0047	phosphoribosylformylglycinamidine synthase activity
FPHI_RS04710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FPHI_RS04725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FPHI_RS04730	COG0154	amidase activity
FPHI_RS04745	COG3240	lipase activity
FPHI_RS04755	COG2814	Major facilitator Superfamily
FPHI_RS04780	COG0076	glutamate decarboxylase activity
FPHI_RS04790	COG0527	aspartate kinase activity
FPHI_RS04800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPHI_RS04805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPHI_RS04810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPHI_RS04815	COG0649	NAD binding
FPHI_RS04820	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FPHI_RS04830	COG1034	ATP synthesis coupled electron transport
FPHI_RS04835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FPHI_RS04840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FPHI_RS04845	COG0839	Belongs to the complex I subunit 6 family
FPHI_RS04850	COG0713	ATP synthesis coupled electron transport
FPHI_RS04875	COG0606	chelatase, subunit chli
FPHI_RS04880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FPHI_RS04890	COG0779	Required for maturation of 30S ribosomal subunits
FPHI_RS04895	COG2251	uridine kinase activity
FPHI_RS04895	COG0195	Participates in both transcription termination and antitermination
FPHI_RS04900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FPHI_RS04905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FPHI_RS04910	COG0124	histidyl-tRNA synthetase
FPHI_RS04920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FPHI_RS04925	COG0564	pseudouridine synthase activity
FPHI_RS04950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FPHI_RS04955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FPHI_RS04960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FPHI_RS04965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FPHI_RS04970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FPHI_RS04975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FPHI_RS04985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FPHI_RS04990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FPHI_RS05000	COG2223	nitrite transmembrane transporter activity
FPHI_RS05015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FPHI_RS05020	COG1053	succinate dehydrogenase
FPHI_RS05025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FPHI_RS05040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FPHI_RS05045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FPHI_RS05050	COG0149	triose-phosphate isomerase activity
FPHI_RS05055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FPHI_RS05075	COG3311	Transcriptional regulator
FPHI_RS05145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FPHI_RS05170	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FPHI_RS05180	COG1294	oxidase, subunit
FPHI_RS05185	COG1271	oxidase subunit
FPHI_RS05190	COG1090	epimerase
FPHI_RS05195	COG0642	Histidine kinase
FPHI_RS05220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FPHI_RS05225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FPHI_RS05245	COG1663	tetraacyldisaccharide 4'-kinase activity
FPHI_RS05250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPHI_RS05250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FPHI_RS05260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FPHI_RS05265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FPHI_RS05270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FPHI_RS05275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FPHI_RS05280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FPHI_RS05285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FPHI_RS05295	COG0552	protein localization to endoplasmic reticulum
FPHI_RS05300	COG0210	DNA helicase
FPHI_RS05305	COG4166	transmembrane transport
FPHI_RS05310	COG0601	transmembrane transport
FPHI_RS05315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FPHI_RS05325	COG4608	Belongs to the ABC transporter superfamily
FPHI_RS05330	COG2814	Major facilitator Superfamily
FPHI_RS05345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FPHI_RS05350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FPHI_RS05355	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FPHI_RS05370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FPHI_RS05390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FPHI_RS05400	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FPHI_RS05410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FPHI_RS05415	COG0081	regulation of translation
FPHI_RS05420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FPHI_RS05425	COG0222	ribosome binding
FPHI_RS05430	COG0085	RNA polymerase activity
FPHI_RS05435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FPHI_RS05445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FPHI_RS05455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FPHI_RS05460	COG0228	four-way junction DNA binding
FPHI_RS05465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FPHI_RS05470	COG0336	Belongs to the RNA methyltransferase TrmD family
FPHI_RS05475	COG0335	large ribosomal subunit rRNA binding
FPHI_RS05480	COG4974	Belongs to the 'phage' integrase family
FPHI_RS05505	COG4221	oxidoreductase activity
FPHI_RS05515	COG0494	nUDIX hydrolase
FPHI_RS05525	COG3023	N-Acetylmuramoyl-L-alanine amidase
FPHI_RS05530	COG3681	Belongs to the UPF0597 family
FPHI_RS05535	COG0814	amino acid
FPHI_RS05545	COG2814	Major facilitator Superfamily
FPHI_RS05550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPHI_RS05560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FPHI_RS05565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FPHI_RS05570	COG2890	protein-(glutamine-N5) methyltransferase activity
FPHI_RS05575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FPHI_RS05580	COG3022	response to hydroperoxide
FPHI_RS05620	COG0463	Glycosyl transferase, family 2
FPHI_RS05640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPHI_RS05645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPHI_RS05660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPHI_RS05670	COG1028	Short-chain dehydrogenase reductase Sdr
FPHI_RS05675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPHI_RS05690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FPHI_RS05695	COG1918	ferrous iron import across plasma membrane
FPHI_RS05710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FPHI_RS05715	COG0459	protein refolding
FPHI_RS05720	COG0531	amino acid
FPHI_RS05725	COG0300	oxidoreductase activity
FPHI_RS05730	COG1404	Belongs to the peptidase S8 family
FPHI_RS05745	COG2081	HI0933 family
FPHI_RS05750	COG2814	Major facilitator Superfamily
FPHI_RS05755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FPHI_RS05770	COG0531	amino acid
FPHI_RS05775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FPHI_RS05780	COG0398	Pfam SNARE associated Golgi protein
FPHI_RS05785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPHI_RS05835	COG0814	amino acid
FPHI_RS05845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPHI_RS05865	COG0742	ribosomal rna small subunit methyltransferase
FPHI_RS05870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FPHI_RS05875	COG0814	amino acid
FPHI_RS05885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FPHI_RS05890	COG0825	malonyl-CoA metabolic process
FPHI_RS05910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FPHI_RS05930	COG0180	Tryptophanyl-tRNA synthetase
FPHI_RS05950	COG0237	dephospho-CoA kinase activity
FPHI_RS05965	COG0156	8-amino-7-oxononanoate synthase activity
FPHI_RS05980	COG2124	cytochrome p450
FPHI_RS05990	COG1368	sulfuric ester hydrolase activity
FPHI_RS05995	COG0300	oxidoreductase activity
FPHI_RS06015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FPHI_RS06050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FPHI_RS06065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FPHI_RS06070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FPHI_RS06100	COG3328	transposase activity
FPHI_RS06155	COG0508	dehydrogenase complex catalyzes the overall conversion of
FPHI_RS06160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPHI_RS06165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FPHI_RS06220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FPHI_RS06225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPHI_RS06230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FPHI_RS06250	COG1183	phosphatidylcholine synthase activity
FPHI_RS06255	COG0142	geranyltranstransferase activity
FPHI_RS06260	COG1519	Transferase
FPHI_RS06265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FPHI_RS06270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FPHI_RS06280	COG0681	Belongs to the peptidase S26 family
FPHI_RS06285	COG0571	ribonuclease III activity
FPHI_RS06290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FPHI_RS06295	COG0557	exoribonuclease II activity
FPHI_RS06320	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FPHI_RS06335	COG5002	protein histidine kinase activity
FPHI_RS06355	COG0500	methyltransferase
FPHI_RS06385	COG0010	Belongs to the arginase family
FPHI_RS06410	COG0183	Belongs to the thiolase family
FPHI_RS06415	COG1024	Enoyl-CoA hydratase
FPHI_RS06415	COG1250	3-hydroxyacyl-CoA dehydrogenase
FPHI_RS06420	COG1960	acyl-CoA dehydrogenase activity
FPHI_RS06425	COG0318	PFAM AMP-dependent synthetase and ligase
FPHI_RS06440	COG1643	Atp-dependent helicase
FPHI_RS06445	COG1086	Polysaccharide biosynthesis protein
FPHI_RS06465	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FPHI_RS06475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FPHI_RS06495	COG1088	dTDP-glucose 4,6-dehydratase activity
FPHI_RS06500	COG1682	transport, permease protein
FPHI_RS06535	COG1216	Glycosyl transferase, family 2
FPHI_RS06540	COG0438	transferase activity, transferring glycosyl groups
FPHI_RS06555	COG1216	Glycosyl transferase, family 2
FPHI_RS06565	COG0438	transferase activity, transferring glycosyl groups
FPHI_RS06570	COG0438	transferase activity, transferring glycosyl groups
FPHI_RS06595	COG0248	Ppx GppA phosphatase
FPHI_RS06600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FPHI_RS06625	COG0084	hydrolase, TatD family'
FPHI_RS06640	COG0730	response to heat
FPHI_RS06650	COG1131	(ABC) transporter
FPHI_RS06655	COG0842	Transport permease protein
FPHI_RS06660	COG0463	Glycosyl transferase, family 2
FPHI_RS06670	COG1280	lysine exporter protein (LysE YggA)
FPHI_RS06675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FPHI_RS06690	COG0402	S-adenosylhomocysteine deaminase activity
FPHI_RS06705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FPHI_RS06710	COG0446	pyridine nucleotide-disulphide oxidoreductase
FPHI_RS06730	COG2983	Belongs to the UPF0260 family
FPHI_RS06760	COG0436	Aminotransferase
FPHI_RS06770	COG2755	lipolytic protein G-D-S-L family
FPHI_RS06770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FPHI_RS06775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FPHI_RS06775	COG2755	lipolytic protein G-D-S-L family
FPHI_RS06780	COG2755	lipolytic protein G-D-S-L family
FPHI_RS06780	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FPHI_RS06785	COG0442	prolyl-tRNA aminoacylation
FPHI_RS06800	COG2166	iron-sulfur cluster assembly
FPHI_RS06820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FPHI_RS06855	COG0500	methyltransferase
FPHI_RS06875	COG0069	glutamate synthase activity
FPHI_RS06885	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FPHI_RS06910	COG0028	Belongs to the TPP enzyme family
FPHI_RS06915	COG1074	ATP-dependent DNA helicase activity
FPHI_RS06920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FPHI_RS06935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FPHI_RS06950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FPHI_RS06970	COG0483	inositol monophosphate 1-phosphatase activity
FPHI_RS06975	COG2855	membrane
FPHI_RS06985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FPHI_RS06985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FPHI_RS06995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FPHI_RS07000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FPHI_RS07005	COG1028	Short-chain dehydrogenase reductase Sdr
FPHI_RS07010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FPHI_RS07020	COG0416	fatty acid biosynthetic process
FPHI_RS07025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FPHI_RS07030	COG1399	metal-binding, possibly nucleic acid-binding protein
FPHI_RS07045	COG0126	phosphoglycerate kinase activity
FPHI_RS07050	COG0469	pyruvate kinase activity
FPHI_RS07055	COG0191	fructose-bisphosphate aldolase activity
FPHI_RS07195	COG0583	DNA-binding transcription factor activity
FPHI_RS07205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FPHI_RS07230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FPHI_RS07250	COG1846	Transcriptional regulator
FPHI_RS07285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FPHI_RS07290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FPHI_RS07300	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FPHI_RS07305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FPHI_RS07310	COG0443	Heat shock 70 kDa protein
FPHI_RS07315	COG0484	heat shock protein binding
FPHI_RS07325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FPHI_RS07340	COG0477	Major facilitator Superfamily
FPHI_RS07360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FPHI_RS07380	COG1127	ABC transporter
FPHI_RS07385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FPHI_RS07395	COG0564	pseudouridine synthase activity
FPHI_RS07400	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FPHI_RS07405	COG0277	FAD linked oxidase domain protein
FPHI_RS07405	COG0277	FAD linked oxidase domain protein
FPHI_RS07415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FPHI_RS07445	COG0037	tRNA processing
FPHI_RS07450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FPHI_RS07455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FPHI_RS07460	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FPHI_RS07465	COG1530	ribonuclease E activity
FPHI_RS07470	COG1104	cysteine desulfurase activity
FPHI_RS07480	COG1381	Involved in DNA repair and RecF pathway recombination
FPHI_RS07485	COG0586	Pfam SNARE associated Golgi protein
FPHI_RS07490	COG0586	Pfam SNARE associated Golgi protein
FPHI_RS07505	COG3079	Belongs to the UPF0149 family
FPHI_RS07510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPHI_RS07515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FPHI_RS07530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FPHI_RS07545	COG0561	phosphatase activity
FPHI_RS07565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FPHI_RS07570	COG0346	lactoylglutathione lyase activity
FPHI_RS07580	COG2226	methyltransferase
FPHI_RS07590	COG1611	Belongs to the LOG family
FPHI_RS07610	COG3220	belongs to the UPF0276 family
FPHI_RS07625	COG0517	IMP dehydrogenase activity
FPHI_RS07625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FPHI_RS07630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FPHI_RS07635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FPHI_RS07640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FPHI_RS07645	COG1132	(ABC) transporter
FPHI_RS07650	COG0367	asparagine synthase
FPHI_RS07655	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FPHI_RS07655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FPHI_RS07665	COG1216	Glycosyl transferase, family 2
FPHI_RS07665	COG1442	glycosyl transferase family 8
FPHI_RS07675	COG0463	Glycosyl transferase, family 2
FPHI_RS07680	COG1442	glycosyl transferase family 8
FPHI_RS07680	COG1216	Glycosyl transferase, family 2
FPHI_RS07685	COG0438	transferase activity, transferring glycosyl groups
FPHI_RS07690	COG1215	transferase activity, transferring glycosyl groups
FPHI_RS07710	COG1446	asparaginase
FPHI_RS07760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FPHI_RS07785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FPHI_RS07785	COG0189	ligase activity
FPHI_RS07790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FPHI_RS07790	COG1181	Belongs to the D-alanine--D-alanine ligase family
FPHI_RS07795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FPHI_RS07800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FPHI_RS07815	COG0814	amino acid
FPHI_RS07820	COG1464	Belongs to the NlpA lipoprotein family
FPHI_RS07830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FPHI_RS07835	COG0343	queuine tRNA-ribosyltransferase activity
FPHI_RS07840	COG0583	DNA-binding transcription factor activity
FPHI_RS07860	COG1335	isochorismatase
FPHI_RS07870	COG3387	PFAM Glycoside hydrolase 15-related
FPHI_RS07875	COG1862	Preprotein translocase
FPHI_RS07880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FPHI_RS07885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FPHI_RS07895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FPHI_RS07910	COG0328	RNA-DNA hybrid ribonuclease activity
FPHI_RS07915	COG0252	asparaginase activity
FPHI_RS07920	COG0288	reversible hydration of carbon dioxide
FPHI_RS07945	COG0732	type I restriction modification DNA specificity domain
FPHI_RS07950	COG1943	Transposase
FPHI_RS07965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FPHI_RS07975	COG0544	peptidyl-prolyl cis-trans isomerase activity
FPHI_RS07980	COG0740	serine-type endopeptidase activity
FPHI_RS07985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FPHI_RS07990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FPHI_RS08005	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FPHI_RS08010	COG1923	regulation of RNA biosynthetic process
FPHI_RS08015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FPHI_RS08025	COG0330	HflC and HflK could
FPHI_RS08030	COG0330	HflC and HflK could
FPHI_RS08035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FPHI_RS08040	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FPHI_RS08050	COG0129	dihydroxy-acid dehydratase activity
FPHI_RS08055	COG0028	Belongs to the TPP enzyme family
FPHI_RS08065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FPHI_RS08070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FPHI_RS08075	COG0670	Belongs to the BI1 family
FPHI_RS08095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FPHI_RS08100	COG2878	Part of a membrane complex involved in electron transport
FPHI_RS08105	COG2999	glutathione oxidoreductase activity
FPHI_RS08120	COG3104	oligopeptide transport
FPHI_RS08125	COG1528	Iron-storage protein
FPHI_RS08130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FPHI_RS08135	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FPHI_RS08140	COG0217	transcriptional regulatory protein
FPHI_RS08145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FPHI_RS08150	COG2271	Major facilitator Superfamily
FPHI_RS08160	COG1322	Protein conserved in bacteria
FPHI_RS08205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FPHI_RS08210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FPHI_RS08215	COG4536	flavin adenine dinucleotide binding
FPHI_RS08225	COG0012	GTP binding
FPHI_RS08230	COG0193	aminoacyl-tRNA hydrolase activity
FPHI_RS08245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FPHI_RS08250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPHI_RS08255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FPHI_RS08260	COG3104	oligopeptide transport
FPHI_RS08265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FPHI_RS08270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FPHI_RS08280	COG0095	Lipoate-protein ligase
FPHI_RS08285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FPHI_RS08290	COG0583	DNA-binding transcription factor activity
FPHI_RS08300	COG3961	Belongs to the TPP enzyme family
FPHI_RS08320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FPHI_RS08335	COG1566	PFAM secretion protein HlyD family protein
FPHI_RS08350	COG1509	lysine 2,3-aminomutase activity
FPHI_RS08360	COG0686	Belongs to the AlaDH PNT family
FPHI_RS08365	COG1278	Cold shock
FPHI_RS08380	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FPHI_RS08395	COG0488	(ABC) transporter
FPHI_RS08405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FPHI_RS08415	COG0039	L-malate dehydrogenase activity
FPHI_RS08425	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FPHI_RS08435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FPHI_RS08450	COG0450	alkyl hydroperoxide reductase
FPHI_RS08460	COG2824	Alkylphosphonate utilization operon protein PhnA
FPHI_RS08480	COG1876	peptidase activity
FPHI_RS08495	COG1012	belongs to the aldehyde dehydrogenase family
FPHI_RS08505	COG1937	Protein conserved in bacteria
FPHI_RS08510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FPHI_RS08515	COG2132	Multicopper oxidase
FPHI_RS08520	COG0583	DNA-binding transcription factor activity
FPHI_RS08535	COG0753	catalase activity
FPHI_RS08545	COG0386	Belongs to the glutathione peroxidase family
FPHI_RS08555	COG4948	Mandelate Racemase Muconate Lactonizing
FPHI_RS08570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FPHI_RS08570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FPHI_RS08590	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FPHI_RS08605	COG0535	radical SAM domain protein
FPHI_RS08630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FPHI_RS08635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FPHI_RS08640	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FPHI_RS08645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FPHI_RS08650	COG2814	Major facilitator Superfamily
FPHI_RS08670	COG0799	negative regulation of ribosome biogenesis
FPHI_RS08680	COG0210	DNA helicase
FPHI_RS08690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FPHI_RS08700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FPHI_RS08715	COG0354	folic acid binding
FPHI_RS08720	COG0210	DNA helicase
FPHI_RS08725	COG2996	Protein conserved in bacteria
FPHI_RS08730	COG0450	alkyl hydroperoxide reductase
FPHI_RS08735	COG0360	Binds together with S18 to 16S ribosomal RNA
FPHI_RS08740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FPHI_RS08745	COG0359	binds to the 23S rRNA
FPHI_RS08755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FPHI_RS08765	COG1187	pseudouridine synthase activity
FPHI_RS08790	COG0142	geranyltranstransferase activity
FPHI_RS08800	COG0037	tRNA processing
FPHI_RS08825	COG1610	YqeY-like protein
FPHI_RS08850	COG2921	Belongs to the UPF0250 family
FPHI_RS08855	COG1686	Belongs to the peptidase S11 family
FPHI_RS08860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FPHI_RS08865	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FPHI_RS08880	COG1137	ATPase activity
FPHI_RS08890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FPHI_RS08895	COG0101	tRNA pseudouridine synthase activity
FPHI_RS08900	COG0519	Catalyzes the synthesis of GMP from XMP
FPHI_RS08900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FPHI_RS08905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FPHI_RS08920	COG2255	four-way junction helicase activity
FPHI_RS08930	COG3655	Transcriptional regulator
FPHI_RS08950	COG3104	oligopeptide transport
FPHI_RS08955	COG0697	spore germination
FPHI_RS08960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FPHI_RS08965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FPHI_RS08965	COG0072	phenylalanine-tRNA ligase activity
FPHI_RS08970	COG0735	belongs to the Fur family
FPHI_RS08975	COG0523	cobalamin synthesis protein
FPHI_RS08990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FPHI_RS09005	COG0489	protein tyrosine kinase activity
FPHI_RS09010	COG0717	Belongs to the dCTP deaminase family
FPHI_RS09045	COG0659	secondary active sulfate transmembrane transporter activity
FPHI_RS09050	COG4969	Belongs to the N-Me-Phe pilin family
FPHI_RS09070	COG0495	leucyl-tRNA aminoacylation
FPHI_RS09075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FPHI_RS09080	COG1678	Uncharacterized ACR, COG1678
FPHI_RS09085	COG0494	nUDIX hydrolase
FPHI_RS09095	COG0833	amino acid
FPHI_RS09115	COG0719	Fe-S assembly protein
FPHI_RS09120	COG0396	ATPase activity
FPHI_RS09125	COG0719	Fe-S assembly protein
FPHI_RS09135	COG0569	domain protein
FPHI_RS09140	COG0531	amino acid
FPHI_RS09165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FPHI_RS09170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FPHI_RS09185	COG2249	NAD(P)H dehydrogenase (quinone) activity
FPHI_RS09195	COG0708	Exodeoxyribonuclease III
FPHI_RS09215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FPHI_RS09220	COG0393	Putative heavy-metal-binding
FPHI_RS09225	COG3104	oligopeptide transport
FPHI_RS09230	COG0513	Belongs to the DEAD box helicase family
FPHI_RS09235	COG0302	gtp cyclohydrolase
FPHI_RS09250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FPHI_RS09250	COG3153	acetyltransferase
FPHI_RS09255	COG0667	Aldo Keto reductase
FPHI_RS09260	COG0667	Aldo Keto reductase
FPHI_RS09270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FPHI_RS09270	COG0512	Glutamine amidotransferase of anthranilate synthase
FPHI_RS09275	COG0512	Glutamine amidotransferase of anthranilate synthase
FPHI_RS09275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FPHI_RS09280	COG0318	PFAM AMP-dependent synthetase and ligase
FPHI_RS09290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FPHI_RS09290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FPHI_RS09305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FPHI_RS09310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FPHI_RS09315	COG0156	8-amino-7-oxononanoate synthase activity
FPHI_RS09320	COG4106	trans-aconitate 2-methyltransferase activity
FPHI_RS09325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FPHI_RS09335	COG1940	carbohydrate kinase activity
FPHI_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
FPHI_RS09355	COG1472	Belongs to the glycosyl hydrolase 3 family
FPHI_RS09360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FPHI_RS09360	COG1017	nitric oxide dioxygenase activity
FPHI_RS09365	COG1959	2 iron, 2 sulfur cluster binding
FPHI_RS09375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FPHI_RS09380	COG0189	ligase activity
FPHI_RS09385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FPHI_RS09400	COG0640	Transcriptional regulator
FPHI_RS09405	COG0798	PFAM Bile acid sodium symporter
FPHI_RS09410	COG2076	Multidrug Resistance protein
FPHI_RS09415	COG0116	Belongs to the methyltransferase superfamily
FPHI_RS09415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FPHI_RS09425	COG0582	viral genome integration into host DNA
FPHI_RS09440	COG1002	Type II restriction enzyme, methylase subunits
FPHI_RS09460	COG1061	Type III restriction enzyme res subunit
FPHI_RS09465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FPHI_RS09475	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
FPHI_RS09515	COG1396	sequence-specific DNA binding
FPHI_RS09535	COG1054	Belongs to the UPF0176 family
FPHI_RS09540	COG0408	coproporphyrinogen oxidase activity
FPHI_RS09545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FPHI_RS09565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FPHI_RS09575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FPHI_RS09585	COG0513	Belongs to the DEAD box helicase family
FPHI_RS09590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FPHI_RS09600	COG2814	Major facilitator Superfamily
FPHI_RS09605	COG1085	galactose-1-phosphate uridylyltransferase
FPHI_RS09610	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FPHI_RS09630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FPHI_RS09635	COG2835	tetraacyldisaccharide 4'-kinase activity
FPHI_RS09640	COG0301	tRNA thio-modification
FPHI_RS09650	COG0322	excinuclease ABC activity
FPHI_RS09655	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FPHI_RS09660	COG2814	Major facilitator Superfamily
FPHI_RS09670	COG0751	glycine-tRNA ligase activity
FPHI_RS09675	COG0084	hydrolase, TatD family'
FPHI_RS09680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FPHI_RS09720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FPHI_RS09725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FPHI_RS09730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FPHI_RS09815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FPHI_RS09820	COG2264	protein methyltransferase activity
FPHI_RS09840	COG0415	Belongs to the DNA photolyase family
FPHI_RS09855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FPHI_RS09860	COG2814	Major facilitator Superfamily
FPHI_RS09865	COG0531	amino acid
FPHI_RS09875	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FPHI_RS09935	COG0732	type I restriction modification DNA specificity domain
FPHI_RS09965	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FPHI_RS09975	COG0277	FAD linked oxidase domain protein