locus-tag	class	description
F7308_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F7308_RS00020	COG0531	amino acid
F7308_RS00060	COG5002	protein histidine kinase activity
F7308_RS00075	COG0745	RESPONSE REGULATOR receiver
F7308_RS00090	COG0814	amino acid
F7308_RS00100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F7308_RS00105	COG0505	Belongs to the CarA family
F7308_RS00140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F7308_RS00150	COG0583	DNA-binding transcription factor activity
F7308_RS00170	COG0284	orotidine-5'-phosphate decarboxylase activity
F7308_RS00185	COG1605	Chorismate mutase
F7308_RS00185	COG0287	Prephenate dehydrogenase
F7308_RS00190	COG1490	D-aminoacyl-tRNA deacylase activity
F7308_RS00210	COG1621	beta-fructofuranosidase activity
F7308_RS00215	COG3104	oligopeptide transport
F7308_RS00220	COG0473	3-isopropylmalate dehydrogenase activity
F7308_RS00225	COG0066	3-isopropylmalate dehydratase activity
F7308_RS00230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F7308_RS00235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F7308_RS00250	COG0574	Belongs to the PEP-utilizing enzyme family
F7308_RS00250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F7308_RS00260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F7308_RS00270	COG1560	Kdo2-lipid A biosynthetic process
F7308_RS00275	COG1560	Kdo2-lipid A biosynthetic process
F7308_RS00280	COG0706	membrane insertase activity
F7308_RS00285	COG0594	ribonuclease P activity
F7308_RS00300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F7308_RS00305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F7308_RS00310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F7308_RS00335	COG0589	response to stress
F7308_RS00355	COG1984	allophanate hydrolase subunit 2
F7308_RS00360	COG2194	sulfuric ester hydrolase activity
F7308_RS00365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F7308_RS00395	COG3038	cytochrome b561
F7308_RS00415	COG0814	amino acid
F7308_RS00420	COG0357	Ribosomal RNA small subunit methyltransferase G
F7308_RS00425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F7308_RS00440	COG2814	Major facilitator Superfamily
F7308_RS00445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F7308_RS00450	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F7308_RS00465	COG0268	Binds directly to 16S ribosomal RNA
F7308_RS00475	COG0482	sulfurtransferase activity
F7308_RS00485	COG0242	peptide deformylase activity
F7308_RS00495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F7308_RS00495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F7308_RS00505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F7308_RS00505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F7308_RS00515	COG3961	Belongs to the TPP enzyme family
F7308_RS00535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F7308_RS00545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F7308_RS00550	COG2137	regulation of response to DNA damage stimulus
F7308_RS00555	COG0629	single-stranded DNA binding
F7308_RS00565	COG0857	belongs to the CobB CobQ family
F7308_RS00565	COG0280	phosphate acetyltransferase
F7308_RS00570	COG1012	belongs to the aldehyde dehydrogenase family
F7308_RS00590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F7308_RS00590	COG3153	acetyltransferase
F7308_RS00600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F7308_RS00610	COG0557	exoribonuclease II activity
F7308_RS00620	COG0181	hydroxymethylbilane synthase activity
F7308_RS00625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F7308_RS00645	COG1176	ABC-type spermidine putrescine transport system, permease component I
F7308_RS00650	COG1116	anion transmembrane transporter activity
F7308_RS00680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F7308_RS00690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F7308_RS00715	COG1176	ABC-type spermidine putrescine transport system, permease component I
F7308_RS00720	COG0658	competence protein
F7308_RS00720	COG2333	competence protein COMEC
F7308_RS00725	COG0204	Acyl-transferase
F7308_RS00735	COG0009	L-threonylcarbamoyladenylate synthase
F7308_RS00745	COG0590	tRNA wobble adenosine to inosine editing
F7308_RS00750	COG1181	Belongs to the D-alanine--D-alanine ligase family
F7308_RS00755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F7308_RS00780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F7308_RS00785	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F7308_RS00790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F7308_RS00800	COG2862	Uncharacterized protein family, UPF0114
F7308_RS00805	COG2066	Belongs to the glutaminase family
F7308_RS00820	COG3040	lipid binding
F7308_RS00825	COG0814	amino acid
F7308_RS00830	COG0138	bifunctional purine biosynthesis protein purh
F7308_RS00835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F7308_RS00855	COG1122	ATPase activity
F7308_RS00865	COG2814	Major facilitator Superfamily
F7308_RS00880	COG1295	ribonuclease BN
F7308_RS00890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F7308_RS00895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F7308_RS00900	COG1294	oxidase, subunit
F7308_RS00905	COG1271	oxidase subunit
F7308_RS00920	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F7308_RS00930	COG0714	Associated with various cellular activities
F7308_RS00950	COG2304	oxidoreductase activity
F7308_RS00965	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
F7308_RS00985	COG0525	valine-tRNA ligase activity
F7308_RS00990	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F7308_RS01010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F7308_RS01030	COG0778	Nitroreductase
F7308_RS01040	COG0114	fumarate hydratase activity
F7308_RS01045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F7308_RS01060	COG1288	antiporter activity
F7308_RS01070	COG1045	serine acetyltransferase
F7308_RS01075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F7308_RS01080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F7308_RS01085	COG0052	Belongs to the universal ribosomal protein uS2 family
F7308_RS01090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F7308_RS01100	COG0233	cytoplasmic translational termination
F7308_RS01105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F7308_RS01110	COG0575	Belongs to the CDS family
F7308_RS01115	COG0756	dUTP diphosphatase activity
F7308_RS01120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F7308_RS01135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F7308_RS01145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F7308_RS01150	COG0088	Forms part of the polypeptide exit tunnel
F7308_RS01155	COG0089	rRNA binding
F7308_RS01160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F7308_RS01165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F7308_RS01170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F7308_RS01180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F7308_RS01200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F7308_RS01210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F7308_RS01215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F7308_RS01220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F7308_RS01225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F7308_RS01235	COG1841	ribosomal large subunit assembly
F7308_RS01240	COG0200	Binds to the 23S rRNA
F7308_RS01245	COG0201	protein transport
F7308_RS01255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F7308_RS01265	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F7308_RS01280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F7308_RS01285	COG0326	Molecular chaperone. Has ATPase activity
F7308_RS01290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F7308_RS01295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F7308_RS01300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F7308_RS01315	COG1438	arginine binding
F7308_RS01320	COG0165	Argininosuccinate lyase
F7308_RS01325	COG0137	argininosuccinate synthase activity
F7308_RS01330	COG1288	antiporter activity
F7308_RS01345	COG0504	CTP synthase activity
F7308_RS01350	COG0105	UTP biosynthetic process
F7308_RS01355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F7308_RS01360	COG0285	dihydrofolate synthase activity
F7308_RS01365	COG0802	atpase or kinase
F7308_RS01380	COG2918	glutathione biosynthetic process
F7308_RS01475	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F7308_RS01485	COG0732	type I restriction modification DNA specificity domain
F7308_RS01490	COG2852	Protein conserved in bacteria
F7308_RS01500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F7308_RS01510	COG0431	NADPH-dependent FMN reductase
F7308_RS01515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F7308_RS01525	COG0798	PFAM Bile acid sodium symporter
F7308_RS01550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F7308_RS01570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F7308_RS01575	COG1674	ftsk spoiiie
F7308_RS01585	COG0833	amino acid
F7308_RS01590	COG2945	thiolester hydrolase activity
F7308_RS01595	COG1494	fructose-1,6-bisphosphatase
F7308_RS01600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F7308_RS01610	COG1253	flavin adenine dinucleotide binding
F7308_RS01655	COG2890	protein-(glutamine-N5) methyltransferase activity
F7308_RS01660	COG2814	Major facilitator Superfamily
F7308_RS01665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F7308_RS01685	COG0531	amino acid
F7308_RS01700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F7308_RS01710	COG2957	Belongs to the agmatine deiminase family
F7308_RS01730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F7308_RS01735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F7308_RS01740	COG1127	ABC transporter
F7308_RS01745	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F7308_RS01755	COG0850	regulation of cytokinetic process
F7308_RS01760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F7308_RS01765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F7308_RS01775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F7308_RS01785	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F7308_RS01800	COG0346	lactoylglutathione lyase activity
F7308_RS01805	COG1051	belongs to the nudix hydrolase family
F7308_RS01810	COG2095	MarC family integral membrane protein
F7308_RS01825	COG2252	PERMEase
F7308_RS01835	COG2985	domain, Protein
F7308_RS01840	COG0758	DNA mediated transformation
F7308_RS01855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F7308_RS01860	COG4401	Chorismate mutase type I
F7308_RS01865	COG1183	phosphatidylcholine synthase activity
F7308_RS01875	COG0811	peptide transport
F7308_RS01905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F7308_RS01920	COG0415	Belongs to the DNA photolyase family
F7308_RS01925	COG3046	protein related to deoxyribodipyrimidine photolyase
F7308_RS01930	COG0385	Bile acid
F7308_RS01965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F7308_RS01975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F7308_RS01995	COG0501	Belongs to the peptidase M48B family
F7308_RS02000	COG1704	LemA family
F7308_RS02005	COG0583	DNA-binding transcription factor activity
F7308_RS02025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F7308_RS02065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F7308_RS02065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F7308_RS02085	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F7308_RS02090	COG0436	Aminotransferase
F7308_RS02095	COG0497	DNA recombination
F7308_RS02110	COG4969	Belongs to the N-Me-Phe pilin family
F7308_RS02115	COG0671	phosphoesterase, PA-phosphatase related
F7308_RS02120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F7308_RS02125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F7308_RS02135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F7308_RS02150	COG0792	nuclease activity
F7308_RS02155	COG0339	signal peptide processing
F7308_RS02195	COG1192	Involved in chromosome partitioning
F7308_RS02200	COG1475	DNA binding
F7308_RS02205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F7308_RS02205	COG0519	Catalyzes the synthesis of GMP from XMP
F7308_RS02215	COG2207	Transcriptional regulator
F7308_RS02220	COG2807	transmembrane transport
F7308_RS02225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F7308_RS02240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F7308_RS02245	COG0196	riboflavin kinase activity
F7308_RS02250	COG0281	malic enzyme
F7308_RS02265	COG1160	GTP binding
F7308_RS02270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F7308_RS02275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F7308_RS02285	COG4106	trans-aconitate 2-methyltransferase activity
F7308_RS02290	COG1040	competence protein
F7308_RS02295	COG0537	adenosine 5'-monophosphoramidase activity
F7308_RS02300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F7308_RS02310	COG2226	methyltransferase
F7308_RS02315	COG0837	glucose binding
F7308_RS02330	COG0009	L-threonylcarbamoyladenylate synthase
F7308_RS02335	COG1739	Uncharacterized protein family UPF0029
F7308_RS02340	COG2271	Major facilitator Superfamily
F7308_RS02385	COG2271	Major facilitator Superfamily
F7308_RS02395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F7308_RS02400	COG1733	regulation of RNA biosynthetic process
F7308_RS02405	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F7308_RS02415	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F7308_RS02420	COG2205	protein histidine kinase activity
F7308_RS02435	COG0814	amino acid
F7308_RS02440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F7308_RS02445	COG0531	amino acid
F7308_RS02450	COG4178	(ABC) transporter
F7308_RS02455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F7308_RS02470	COG0826	peptidase U32
F7308_RS02485	COG0583	DNA-binding transcription factor activity
F7308_RS02495	COG1538	Outer membrane efflux protein
F7308_RS02510	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F7308_RS02515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F7308_RS02515	COG0047	phosphoribosylformylglycinamidine synthase activity
F7308_RS02540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F7308_RS02555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F7308_RS02560	COG0154	amidase activity
F7308_RS02575	COG3240	lipase activity
F7308_RS02585	COG2814	Major facilitator Superfamily
F7308_RS02610	COG0076	glutamate decarboxylase activity
F7308_RS02620	COG0527	aspartate kinase activity
F7308_RS02630	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F7308_RS02640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F7308_RS02645	COG0649	NAD binding
F7308_RS02650	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F7308_RS02660	COG1034	ATP synthesis coupled electron transport
F7308_RS02665	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F7308_RS02670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F7308_RS02675	COG0839	Belongs to the complex I subunit 6 family
F7308_RS02680	COG0713	ATP synthesis coupled electron transport
F7308_RS02705	COG0606	chelatase, subunit chli
F7308_RS02710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F7308_RS02720	COG0779	Required for maturation of 30S ribosomal subunits
F7308_RS02725	COG2251	uridine kinase activity
F7308_RS02725	COG0195	Participates in both transcription termination and antitermination
F7308_RS02735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F7308_RS02740	COG0124	histidyl-tRNA synthetase
F7308_RS02750	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F7308_RS02755	COG0564	pseudouridine synthase activity
F7308_RS02780	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F7308_RS02785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F7308_RS02790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F7308_RS02800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F7308_RS02805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F7308_RS02815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F7308_RS02830	COG2223	nitrite transmembrane transporter activity
F7308_RS02840	COG2009	succinate dehydrogenase
F7308_RS02845	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F7308_RS02850	COG1053	succinate dehydrogenase
F7308_RS02855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F7308_RS02870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F7308_RS02875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F7308_RS02880	COG0149	triose-phosphate isomerase activity
F7308_RS02885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F7308_RS02895	COG0582	viral genome integration into host DNA
F7308_RS02955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F7308_RS02990	COG1294	oxidase, subunit
F7308_RS02995	COG1271	oxidase subunit
F7308_RS03000	COG1090	epimerase
F7308_RS03030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F7308_RS03035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F7308_RS03055	COG1663	tetraacyldisaccharide 4'-kinase activity
F7308_RS03060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F7308_RS03060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F7308_RS03070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F7308_RS03075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F7308_RS03080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F7308_RS03085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F7308_RS03090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F7308_RS03095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F7308_RS03105	COG0552	protein localization to endoplasmic reticulum
F7308_RS03110	COG0210	DNA helicase
F7308_RS03130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F7308_RS03140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F7308_RS03155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F7308_RS03185	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F7308_RS03195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F7308_RS03200	COG0081	regulation of translation
F7308_RS03205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F7308_RS03215	COG0085	RNA polymerase activity
F7308_RS03220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F7308_RS03230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F7308_RS03240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F7308_RS03250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F7308_RS03255	COG0336	Belongs to the RNA methyltransferase TrmD family
F7308_RS03260	COG0335	large ribosomal subunit rRNA binding
F7308_RS03265	COG4974	Belongs to the 'phage' integrase family
F7308_RS03290	COG4221	oxidoreductase activity
F7308_RS03300	COG0494	nUDIX hydrolase
F7308_RS03315	COG3681	Belongs to the UPF0597 family
F7308_RS03325	COG2814	Major facilitator Superfamily
F7308_RS03330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F7308_RS03340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F7308_RS03345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F7308_RS03350	COG2890	protein-(glutamine-N5) methyltransferase activity
F7308_RS03355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F7308_RS03360	COG3022	response to hydroperoxide
F7308_RS03395	COG0463	Glycosyl transferase, family 2
F7308_RS03415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F7308_RS03420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F7308_RS03435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F7308_RS03445	COG1028	Short-chain dehydrogenase reductase Sdr
F7308_RS03450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F7308_RS03465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F7308_RS03470	COG1918	ferrous iron import across plasma membrane
F7308_RS03485	COG2267	carboxylic ester hydrolase activity
F7308_RS03490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F7308_RS03495	COG0459	protein refolding
F7308_RS03505	COG0300	oxidoreductase activity
F7308_RS03510	COG1404	Belongs to the peptidase S8 family
F7308_RS03525	COG2081	HI0933 family
F7308_RS03535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F7308_RS03555	COG0531	amino acid
F7308_RS03560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F7308_RS03565	COG0398	Pfam SNARE associated Golgi protein
F7308_RS03570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F7308_RS03605	COG0814	amino acid
F7308_RS03615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F7308_RS03635	COG0742	ribosomal rna small subunit methyltransferase
F7308_RS03640	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F7308_RS03645	COG0814	amino acid
F7308_RS03655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F7308_RS03660	COG0825	malonyl-CoA metabolic process
F7308_RS03680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F7308_RS03700	COG0180	Tryptophanyl-tRNA synthetase
F7308_RS03720	COG0237	dephospho-CoA kinase activity
F7308_RS03730	COG0604	alcohol dehydrogenase
F7308_RS03730	COG3321	synthase
F7308_RS03735	COG0156	8-amino-7-oxononanoate synthase activity
F7308_RS03750	COG0300	oxidoreductase activity
F7308_RS03755	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F7308_RS03815	COG1216	Glycosyl transferase, family 2
F7308_RS03820	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F7308_RS03840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F7308_RS03845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F7308_RS03920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F7308_RS03925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F7308_RS03965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F7308_RS03975	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F7308_RS03995	COG1183	phosphatidylcholine synthase activity
F7308_RS04000	COG0142	geranyltranstransferase activity
F7308_RS04005	COG1519	Transferase
F7308_RS04010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F7308_RS04015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F7308_RS04025	COG0681	Belongs to the peptidase S26 family
F7308_RS04030	COG0571	ribonuclease III activity
F7308_RS04035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F7308_RS04040	COG0557	exoribonuclease II activity
F7308_RS04065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F7308_RS04080	COG5002	protein histidine kinase activity
F7308_RS04100	COG0500	methyltransferase
F7308_RS04130	COG0010	Belongs to the arginase family
F7308_RS04155	COG0183	Belongs to the thiolase family
F7308_RS04160	COG1250	3-hydroxyacyl-CoA dehydrogenase
F7308_RS04160	COG1024	Enoyl-CoA hydratase
F7308_RS04165	COG1960	acyl-CoA dehydrogenase activity
F7308_RS04170	COG0318	PFAM AMP-dependent synthetase and ligase
F7308_RS04175	COG1393	Belongs to the ArsC family
F7308_RS04185	COG1643	Atp-dependent helicase
F7308_RS04190	COG1086	Polysaccharide biosynthesis protein
F7308_RS04210	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F7308_RS04215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F7308_RS04260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F7308_RS04280	COG0463	Glycosyl transferase, family 2
F7308_RS04300	COG1621	beta-fructofuranosidase activity
F7308_RS04325	COG0438	transferase activity, transferring glycosyl groups
F7308_RS04330	COG0438	transferase activity, transferring glycosyl groups
F7308_RS04345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F7308_RS04345	COG2755	lipolytic protein G-D-S-L family
F7308_RS04350	COG1682	transport, permease protein
F7308_RS04355	COG1134	teichoic acid transport
F7308_RS04360	COG1216	Glycosyl transferase, family 2
F7308_RS04370	COG0438	transferase activity, transferring glycosyl groups
F7308_RS04400	COG0248	Ppx GppA phosphatase
F7308_RS04405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F7308_RS04525	COG0084	hydrolase, TatD family'
F7308_RS04530	COG3264	Mechanosensitive ion channel
F7308_RS04530	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F7308_RS04545	COG0730	response to heat
F7308_RS04555	COG1131	(ABC) transporter
F7308_RS04560	COG0842	Transport permease protein
F7308_RS04565	COG0463	Glycosyl transferase, family 2
F7308_RS04575	COG1280	lysine exporter protein (LysE YggA)
F7308_RS04580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F7308_RS04595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F7308_RS04600	COG0402	S-adenosylhomocysteine deaminase activity
F7308_RS04610	COG0640	Transcriptional regulator
F7308_RS04615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F7308_RS04620	COG0446	pyridine nucleotide-disulphide oxidoreductase
F7308_RS04645	COG2983	Belongs to the UPF0260 family
F7308_RS04655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F7308_RS04670	COG0436	Aminotransferase
F7308_RS04675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F7308_RS04675	COG2755	lipolytic protein G-D-S-L family
F7308_RS04685	COG0442	prolyl-tRNA aminoacylation
F7308_RS04700	COG2166	iron-sulfur cluster assembly
F7308_RS04720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F7308_RS04770	COG0069	glutamate synthase activity
F7308_RS04775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F7308_RS04800	COG3384	dioxygenase
F7308_RS04815	COG1074	ATP-dependent DNA helicase activity
F7308_RS04820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F7308_RS04835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F7308_RS04850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F7308_RS04875	COG0483	inositol monophosphate 1-phosphatase activity
F7308_RS04880	COG2855	membrane
F7308_RS04900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F7308_RS04905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F7308_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
F7308_RS04915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F7308_RS04925	COG0416	fatty acid biosynthetic process
F7308_RS04930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F7308_RS04935	COG1399	metal-binding, possibly nucleic acid-binding protein
F7308_RS04950	COG0126	phosphoglycerate kinase activity
F7308_RS04955	COG0469	pyruvate kinase activity
F7308_RS04960	COG0191	fructose-bisphosphate aldolase activity
F7308_RS05085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F7308_RS05100	COG0583	DNA-binding transcription factor activity
F7308_RS05110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F7308_RS05120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F7308_RS05135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F7308_RS05175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F7308_RS05180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F7308_RS05195	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F7308_RS05200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F7308_RS05205	COG0443	Heat shock 70 kDa protein
F7308_RS05220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F7308_RS05230	COG1566	PFAM secretion protein HlyD family protein
F7308_RS05235	COG0477	Major facilitator Superfamily
F7308_RS05245	COG0318	PFAM AMP-dependent synthetase and ligase
F7308_RS05255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F7308_RS05275	COG1127	ABC transporter
F7308_RS05280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F7308_RS05290	COG0564	pseudouridine synthase activity
F7308_RS05295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F7308_RS05300	COG0277	FAD linked oxidase domain protein
F7308_RS05300	COG0277	FAD linked oxidase domain protein
F7308_RS05305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F7308_RS05310	COG3028	Belongs to the UPF0307 family
F7308_RS05340	COG3104	oligopeptide transport
F7308_RS05345	COG0037	tRNA processing
F7308_RS05350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F7308_RS05355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F7308_RS05360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F7308_RS05365	COG1530	ribonuclease E activity
F7308_RS05380	COG1381	Involved in DNA repair and RecF pathway recombination
F7308_RS05385	COG0586	Pfam SNARE associated Golgi protein
F7308_RS05390	COG0586	Pfam SNARE associated Golgi protein
F7308_RS05405	COG3079	Belongs to the UPF0149 family
F7308_RS05410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F7308_RS05415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F7308_RS05430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F7308_RS05440	COG0561	phosphatase activity
F7308_RS05460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F7308_RS05465	COG0346	lactoylglutathione lyase activity
F7308_RS05475	COG2226	methyltransferase
F7308_RS05485	COG1611	Belongs to the LOG family
F7308_RS05505	COG3220	belongs to the UPF0276 family
F7308_RS05520	COG0517	IMP dehydrogenase activity
F7308_RS05520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F7308_RS05525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F7308_RS05530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F7308_RS05545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F7308_RS05555	COG1132	(ABC) transporter
F7308_RS05565	COG1442	glycosyl transferase family 8
F7308_RS05565	COG1216	Glycosyl transferase, family 2
F7308_RS05570	COG1216	Glycosyl transferase, family 2
F7308_RS05570	COG1442	glycosyl transferase family 8
F7308_RS05590	COG1105	Belongs to the carbohydrate kinase PfkB family
F7308_RS05600	COG1446	asparaginase
F7308_RS05630	COG0477	Major facilitator Superfamily
F7308_RS05650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F7308_RS05655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F7308_RS05660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F7308_RS05665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F7308_RS05670	COG0509	glycine decarboxylation via glycine cleavage system
F7308_RS05680	COG3397	chitin binding
F7308_RS05685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F7308_RS05715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F7308_RS05730	COG0445	tRNA wobble uridine modification
F7308_RS05750	COG4221	oxidoreductase activity
F7308_RS05755	COG2925	Exonuclease
F7308_RS05765	COG0556	nucleotide-excision repair
F7308_RS05780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F7308_RS05800	COG0352	thiamine-phosphate diphosphorylase activity
F7308_RS05805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F7308_RS05810	COG0477	Major facilitator Superfamily
F7308_RS05815	COG0477	Major facilitator Superfamily
F7308_RS05830	COG2308	Evidence 4 Homologs of previously reported genes of
F7308_RS05855	COG1570	exodeoxyribonuclease VII activity
F7308_RS05875	COG0477	Major facilitator Superfamily
F7308_RS05885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F7308_RS05890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F7308_RS05895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F7308_RS05900	COG0131	Imidazoleglycerol-phosphate dehydratase
F7308_RS05900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F7308_RS05910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F7308_RS05915	COG0107	imidazoleglycerol-phosphate synthase activity
F7308_RS05920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F7308_RS05920	COG0140	phosphoribosyl-ATP diphosphatase activity
F7308_RS05930	COG0037	tRNA processing
F7308_RS05935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F7308_RS05940	COG2867	negative regulation of translational initiation
F7308_RS05945	COG2914	Belongs to the UPF0125 (RnfH) family
F7308_RS05955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F7308_RS05955	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F7308_RS05960	COG2853	Lipoprotein
F7308_RS05965	COG0405	Gamma-glutamyltransferase
F7308_RS05970	COG1028	Short-chain dehydrogenase reductase Sdr
F7308_RS05985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F7308_RS05990	COG1773	rubredoxin
F7308_RS06000	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F7308_RS06010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F7308_RS06015	COG2814	Major facilitator Superfamily
F7308_RS06035	COG1496	oxidoreductase activity
F7308_RS06070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F7308_RS06075	COG4535	Mg2 and Co2 transporter CorC
F7308_RS06080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F7308_RS06085	COG1702	phosphate starvation-inducible protein PhoH
F7308_RS06090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F7308_RS06095	COG4122	O-methyltransferase activity
F7308_RS06115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F7308_RS06120	COG1214	PFAM Peptidase M22, glycoprotease
F7308_RS06130	COG0436	Aminotransferase
F7308_RS06145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F7308_RS06155	COG0277	FAD linked oxidase domain protein
F7308_RS06160	COG0563	adenylate kinase activity
F7308_RS06190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F7308_RS06210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F7308_RS06220	COG0531	amino acid
F7308_RS06225	COG2814	Major facilitator Superfamily
F7308_RS06230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F7308_RS06245	COG0415	Belongs to the DNA photolyase family
F7308_RS06265	COG2264	protein methyltransferase activity
F7308_RS06270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F7308_RS06300	COG0488	(ABC) transporter
F7308_RS06305	COG2814	Major facilitator Superfamily
F7308_RS06310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F7308_RS06315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F7308_RS06320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F7308_RS06330	COG0039	L-malate dehydrogenase activity
F7308_RS06340	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
F7308_RS06350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F7308_RS06365	COG0450	alkyl hydroperoxide reductase
F7308_RS06375	COG2824	Alkylphosphonate utilization operon protein PhnA
F7308_RS06395	COG1876	peptidase activity
F7308_RS06410	COG1012	belongs to the aldehyde dehydrogenase family
F7308_RS06420	COG0583	DNA-binding transcription factor activity
F7308_RS06435	COG0753	catalase activity
F7308_RS06450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F7308_RS06455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F7308_RS06460	COG0408	coproporphyrinogen oxidase activity
F7308_RS06465	COG1054	Belongs to the UPF0176 family
F7308_RS06490	COG0116	Belongs to the methyltransferase superfamily
F7308_RS06490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F7308_RS06495	COG2076	Multidrug Resistance protein
F7308_RS06500	COG0798	PFAM Bile acid sodium symporter
F7308_RS06505	COG0640	Transcriptional regulator
F7308_RS06515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F7308_RS06520	COG0189	ligase activity
F7308_RS06525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F7308_RS06535	COG1959	2 iron, 2 sulfur cluster binding
F7308_RS06540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F7308_RS06540	COG1017	nitric oxide dioxygenase activity
F7308_RS06545	COG1472	Belongs to the glycosyl hydrolase 3 family
F7308_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
F7308_RS06570	COG1940	carbohydrate kinase activity
F7308_RS06580	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F7308_RS06585	COG4106	trans-aconitate 2-methyltransferase activity
F7308_RS06590	COG0156	8-amino-7-oxononanoate synthase activity
F7308_RS06595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F7308_RS06600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F7308_RS06615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F7308_RS06615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F7308_RS06625	COG0318	PFAM AMP-dependent synthetase and ligase
F7308_RS06630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F7308_RS06630	COG0512	Glutamine amidotransferase of anthranilate synthase
F7308_RS06635	COG0512	Glutamine amidotransferase of anthranilate synthase
F7308_RS06645	COG0667	Aldo Keto reductase
F7308_RS06650	COG0667	Aldo Keto reductase
F7308_RS06670	COG0302	gtp cyclohydrolase
F7308_RS06675	COG0513	Belongs to the DEAD box helicase family
F7308_RS06680	COG3104	oligopeptide transport
F7308_RS06685	COG0393	Putative heavy-metal-binding
F7308_RS06690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F7308_RS06710	COG0708	Exodeoxyribonuclease III
F7308_RS06720	COG2249	NAD(P)H dehydrogenase (quinone) activity
F7308_RS06740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F7308_RS06745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F7308_RS06770	COG0531	amino acid
F7308_RS06775	COG0569	domain protein
F7308_RS06785	COG0719	Fe-S assembly protein
F7308_RS06790	COG0396	ATPase activity
F7308_RS06795	COG0719	Fe-S assembly protein
F7308_RS06805	COG3118	belongs to the thioredoxin family
F7308_RS06815	COG0833	amino acid
F7308_RS06825	COG0494	nUDIX hydrolase
F7308_RS06830	COG1678	Uncharacterized ACR, COG1678
F7308_RS06835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F7308_RS06840	COG0495	leucyl-tRNA aminoacylation
F7308_RS06850	COG0668	transmembrane transport
F7308_RS06855	COG0717	Belongs to the dCTP deaminase family
F7308_RS06860	COG0489	protein tyrosine kinase activity
F7308_RS06890	COG0523	cobalamin synthesis protein
F7308_RS06895	COG0735	belongs to the Fur family
F7308_RS06910	COG0730	response to heat
F7308_RS06915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F7308_RS06915	COG0072	phenylalanine-tRNA ligase activity
F7308_RS06920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F7308_RS06925	COG0697	spore germination
F7308_RS06930	COG3104	oligopeptide transport
F7308_RS06935	COG2211	Major facilitator Superfamily
F7308_RS06945	COG0246	Mannitol dehydrogenase
F7308_RS06955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F7308_RS06960	COG0800	Aldolase
F7308_RS06965	COG1904	glucuronate isomerase
F7308_RS06970	COG2814	Major facilitator Superfamily
F7308_RS07000	COG3655	Transcriptional regulator
F7308_RS07010	COG2255	four-way junction helicase activity
F7308_RS07025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F7308_RS07030	COG0519	Catalyzes the synthesis of GMP from XMP
F7308_RS07030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F7308_RS07035	COG0101	tRNA pseudouridine synthase activity
F7308_RS07040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F7308_RS07050	COG1137	ATPase activity
F7308_RS07065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F7308_RS07070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F7308_RS07075	COG1686	Belongs to the peptidase S11 family
F7308_RS07080	COG2921	Belongs to the UPF0250 family
F7308_RS07105	COG1610	YqeY-like protein
F7308_RS07115	COG2027	D-alanyl-D-alanine carboxypeptidase
F7308_RS07130	COG0037	tRNA processing
F7308_RS07140	COG0142	geranyltranstransferase activity
F7308_RS07165	COG1187	pseudouridine synthase activity
F7308_RS07175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F7308_RS07185	COG0359	binds to the 23S rRNA
F7308_RS07190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F7308_RS07195	COG0360	Binds together with S18 to 16S ribosomal RNA
F7308_RS07200	COG2996	Protein conserved in bacteria
F7308_RS07215	COG0210	DNA helicase
F7308_RS07220	COG0354	folic acid binding
F7308_RS07235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F7308_RS07245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F7308_RS07255	COG0210	DNA helicase
F7308_RS07285	COG2814	Major facilitator Superfamily
F7308_RS07290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F7308_RS07295	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F7308_RS07300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F7308_RS07305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F7308_RS07315	COG2988	succinylglutamate desuccinylase activity
F7308_RS07335	COG0535	radical SAM domain protein
F7308_RS07350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F7308_RS07350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F7308_RS07370	COG4948	Mandelate Racemase Muconate Lactonizing
F7308_RS07380	COG0386	Belongs to the glutathione peroxidase family
F7308_RS07395	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F7308_RS07405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F7308_RS07415	COG0513	Belongs to the DEAD box helicase family
F7308_RS07420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F7308_RS07425	COG2814	Major facilitator Superfamily
F7308_RS07430	COG2814	Major facilitator Superfamily
F7308_RS07435	COG1085	galactose-1-phosphate uridylyltransferase
F7308_RS07440	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F7308_RS07460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F7308_RS07465	COG2835	tetraacyldisaccharide 4'-kinase activity
F7308_RS07475	COG0482	sulfurtransferase activity
F7308_RS07485	COG0322	excinuclease ABC activity
F7308_RS07495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F7308_RS07500	COG2814	Major facilitator Superfamily
F7308_RS07510	COG0751	glycine-tRNA ligase activity
F7308_RS07515	COG0084	hydrolase, TatD family'
F7308_RS07520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F7308_RS07545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F7308_RS07550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F7308_RS07555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F7308_RS07580	COG1278	Cold shock
F7308_RS07585	COG1509	lysine 2,3-aminomutase activity
F7308_RS07620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F7308_RS07625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F7308_RS07630	COG0095	Lipoate-protein ligase
F7308_RS07640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F7308_RS07645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F7308_RS07650	COG3104	oligopeptide transport
F7308_RS07655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F7308_RS07660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F7308_RS07665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F7308_RS07680	COG0193	aminoacyl-tRNA hydrolase activity
F7308_RS07685	COG0012	GTP binding
F7308_RS07695	COG4536	flavin adenine dinucleotide binding
F7308_RS07700	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F7308_RS07705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F7308_RS07720	COG2271	Major facilitator Superfamily
F7308_RS07750	COG1322	Protein conserved in bacteria
F7308_RS07770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F7308_RS07775	COG0217	transcriptional regulatory protein
F7308_RS07780	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F7308_RS07785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F7308_RS07790	COG1528	Iron-storage protein
F7308_RS07795	COG3104	oligopeptide transport
F7308_RS07805	COG2999	glutathione oxidoreductase activity
F7308_RS07810	COG2878	Part of a membrane complex involved in electron transport
F7308_RS07815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F7308_RS07830	COG0670	Belongs to the BI1 family
F7308_RS07835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F7308_RS07845	COG0028	Belongs to the TPP enzyme family
F7308_RS07850	COG0129	dihydroxy-acid dehydratase activity
F7308_RS07855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F7308_RS07860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F7308_RS07865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F7308_RS07870	COG0330	HflC and HflK could
F7308_RS07885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F7308_RS07895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F7308_RS07910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F7308_RS07915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F7308_RS07920	COG0740	serine-type endopeptidase activity
F7308_RS07925	COG0544	peptidyl-prolyl cis-trans isomerase activity
F7308_RS07935	COG0288	reversible hydration of carbon dioxide
F7308_RS07940	COG0252	asparaginase activity
F7308_RS07945	COG0328	RNA-DNA hybrid ribonuclease activity
F7308_RS07960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F7308_RS07970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F7308_RS07975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F7308_RS07980	COG1862	Preprotein translocase
F7308_RS07985	COG3387	PFAM Glycoside hydrolase 15-related
F7308_RS07995	COG1335	isochorismatase
F7308_RS08005	COG0583	DNA-binding transcription factor activity
F7308_RS08010	COG0343	queuine tRNA-ribosyltransferase activity
F7308_RS08015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F7308_RS08025	COG1464	Belongs to the NlpA lipoprotein family
F7308_RS08030	COG0814	amino acid
F7308_RS08035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F7308_RS08040	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F7308_RS08045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F7308_RS08045	COG1181	Belongs to the D-alanine--D-alanine ligase family
F7308_RS08050	COG1181	Belongs to the D-alanine--D-alanine ligase family
F7308_RS08050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F7308_RS08080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F7308_RS08085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F7308_RS08090	COG2151	metal-sulfur cluster biosynthetic enzyme
F7308_RS08100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F7308_RS08105	COG1760	l-serine dehydratase
F7308_RS08120	COG0077	Prephenate dehydratase
F7308_RS08120	COG1605	Chorismate mutase
F7308_RS08125	COG0531	amino acid
F7308_RS08130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F7308_RS08135	COG3104	oligopeptide transport
F7308_RS08155	COG0560	Phosphoserine phosphatase
F7308_RS08180	COG3842	ATPase activity
F7308_RS08185	COG1176	ABC-type spermidine putrescine transport system, permease component I
F7308_RS08190	COG1177	transmembrane transport
F7308_RS08195	COG1280	lysine exporter protein (LysE YggA)
F7308_RS08200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F7308_RS08205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F7308_RS08210	COG0519	Catalyzes the synthesis of GMP from XMP
F7308_RS08230	COG0813	purine-nucleoside phosphorylase activity
F7308_RS08235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F7308_RS08240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F7308_RS08245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F7308_RS08255	COG0166	Belongs to the GPI family
F7308_RS08265	COG0517	IMP dehydrogenase activity
F7308_RS08265	COG0516	GMP reductase activity
F7308_RS08280	COG0795	lipopolysaccharide-transporting ATPase activity
F7308_RS08285	COG0795	lipopolysaccharide-transporting ATPase activity
F7308_RS08290	COG0612	Peptidase, M16
F7308_RS08300	COG0742	ribosomal rna small subunit methyltransferase
F7308_RS08305	COG0583	DNA-binding transcription factor activity
F7308_RS08310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F7308_RS08315	COG1012	belongs to the aldehyde dehydrogenase family
F7308_RS08320	COG0531	amino acid
F7308_RS08325	COG2860	membrane
F7308_RS08335	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F7308_RS08340	COG0295	cytidine deaminase activity
F7308_RS08345	COG3104	oligopeptide transport
F7308_RS08360	COG0247	lactate metabolic process
F7308_RS08360	COG0277	FAD linked oxidase domain protein
F7308_RS08365	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F7308_RS08370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F7308_RS08385	COG1940	carbohydrate kinase activity
F7308_RS08410	COG4988	ABC transporter
F7308_RS08415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F7308_RS08430	COG0251	oxidation-reduction process
F7308_RS08435	COG0659	secondary active sulfate transmembrane transporter activity
F7308_RS08440	COG0842	Transport permease protein
F7308_RS08445	COG1131	(ABC) transporter
F7308_RS08455	COG0584	glycerophosphoryl diester phosphodiesterase
F7308_RS08460	COG2271	Major facilitator Superfamily
F7308_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
F7308_RS08505	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F7308_RS08510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F7308_RS08515	COG0477	Major facilitator Superfamily
F7308_RS08525	COG0534	Mate efflux family protein
F7308_RS08535	COG0788	formyltetrahydrofolate deformylase activity
F7308_RS08540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F7308_RS08550	COG0156	8-amino-7-oxononanoate synthase activity
F7308_RS08555	COG1063	alcohol dehydrogenase
F7308_RS08560	COG0814	amino acid
F7308_RS08565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F7308_RS08570	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F7308_RS08615	COG1758	RNA polymerase activity
F7308_RS08620	COG0572	uridine kinase
F7308_RS08625	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F7308_RS08630	COG0316	Belongs to the HesB IscA family
F7308_RS08635	COG1185	polyribonucleotide nucleotidyltransferase activity
F7308_RS08640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F7308_RS08650	COG3116	cell division
F7308_RS08655	COG0275	rRNA processing
F7308_RS08660	COG0318	PFAM AMP-dependent synthetase and ligase
F7308_RS08660	COG0204	Acyl-transferase
F7308_RS08665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F7308_RS08670	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F7308_RS08675	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F7308_RS08690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F7308_RS08710	COG0045	succinate-CoA ligase (ADP-forming) activity
F7308_RS08715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F7308_RS08730	COG0628	permease
F7308_RS08740	COG3104	oligopeptide transport
F7308_RS08745	COG1446	asparaginase
F7308_RS08765	COG0546	phosphoglycolate phosphatase activity
F7308_RS08770	COG0492	ferredoxin-NADP+ reductase activity
F7308_RS08785	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F7308_RS08800	COG1162	GTPase activity
F7308_RS08810	COG0531	amino acid
F7308_RS08820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F7308_RS08830	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F7308_RS08835	COG0668	transmembrane transport
F7308_RS08845	COG0439	Biotin carboxylase
F7308_RS08855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F7308_RS08860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F7308_RS08865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F7308_RS08870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F7308_RS08885	COG3104	oligopeptide transport
F7308_RS08890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F7308_RS08905	COG0470	DNA polymerase III
F7308_RS08910	COG0616	signal peptide processing
F7308_RS08915	COG0625	glutathione transferase activity
F7308_RS08920	COG2920	part of a sulfur-relay system
F7308_RS08925	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F7308_RS08930	COG0772	Belongs to the SEDS family
F7308_RS08935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F7308_RS08940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F7308_RS08950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F7308_RS08955	COG3104	oligopeptide transport
F7308_RS08960	COG0488	(ABC) transporter
F7308_RS08975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F7308_RS08980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F7308_RS08985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F7308_RS08995	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F7308_RS09005	COG0527	aspartate kinase activity
F7308_RS09005	COG0460	homoserine dehydrogenase
F7308_RS09010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F7308_RS09020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F7308_RS09035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F7308_RS09040	COG0752	glycyl-tRNA synthetase alpha subunit
F7308_RS09050	COG1640	4-alpha-glucanotransferase
F7308_RS09055	COG0058	SHG alpha-glucan phosphorylase activity
F7308_RS09060	COG0297	glycogen (starch) synthase activity
F7308_RS09065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F7308_RS09070	COG0033	Phosphoglucomutase
F7308_RS09075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F7308_RS09080	COG1523	belongs to the glycosyl hydrolase 13 family
F7308_RS09110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F7308_RS09115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F7308_RS09125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F7308_RS09130	COG1982	Orn Lys Arg decarboxylase major
F7308_RS09150	COG0242	peptide deformylase activity
F7308_RS09155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F7308_RS09155	COG2755	lipolytic protein G-D-S-L family
F7308_RS09170	COG1401	restriction endodeoxyribonuclease activity
F7308_RS09170	COG1401	restriction endodeoxyribonuclease activity
F7308_RS09185	COG0587	DNA-directed DNA polymerase activity
F7308_RS09190	COG0668	transmembrane transport
F7308_RS09215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F7308_RS09220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F7308_RS09230	COG0024	Methionine aminopeptidase
F7308_RS09235	COG0583	DNA-binding transcription factor activity
F7308_RS09240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F7308_RS09265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F7308_RS09270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F7308_RS09275	COG1051	belongs to the nudix hydrolase family
F7308_RS09275	COG1056	cytidyltransferase-related domain
F7308_RS09285	COG0688	phosphatidylethanolamine metabolic process
F7308_RS09295	COG1994	Peptidase M50
F7308_RS09335	COG0436	Aminotransferase
F7308_RS09345	COG2171	N-acyltransferase activity
F7308_RS09350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F7308_RS09355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F7308_RS09360	COG0527	aspartate kinase activity
F7308_RS09560	COG3608	succinylglutamate desuccinylase aspartoacylase
F7308_RS09565	COG0133	tryptophan synthase activity
F7308_RS09585	COG0542	response to heat
F7308_RS09615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F7308_RS09625	COG0204	Acyl-transferase
F7308_RS09660	COG0375	protein maturation
F7308_RS09680	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F7308_RS09685	COG0298	carbon dioxide binding
F7308_RS09690	COG0409	Hydrogenase expression formation protein
F7308_RS09710	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
F7308_RS09720	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F7308_RS09730	COG0113	porphobilinogen synthase activity
F7308_RS09750	COG0488	(ABC) transporter
F7308_RS09755	COG0477	Major facilitator Superfamily
F7308_RS09775	COG0583	DNA-binding transcription factor activity
F7308_RS09795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F7308_RS09800	COG0308	aminopeptidase N
F7308_RS09805	COG0134	indole-3-glycerol-phosphate synthase activity
F7308_RS09805	COG0135	phosphoribosylanthranilate isomerase activity
F7308_RS09825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F7308_RS09830	COG0512	Glutamine amidotransferase of anthranilate synthase
F7308_RS09835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F7308_RS09855	COG1530	ribonuclease E activity
F7308_RS09890	COG0582	viral genome integration into host DNA
F7308_RS09895	COG3397	chitin binding
F7308_RS09900	COG1215	transferase activity, transferring glycosyl groups
F7308_RS09915	COG0583	DNA-binding transcription factor activity
F7308_RS09920	COG0583	DNA-binding transcription factor activity
F7308_RS09935	COG2814	Major facilitator Superfamily
F7308_RS09975	COG3397	chitin binding
F7308_RS10050	COG0789	Transcriptional regulator