locus-tag	class	description
F3Y02_RS00015	COG0833	amino acid
F3Y02_RS00050	COG0719	Fe-S assembly protein
F3Y02_RS00055	COG0396	ATPase activity
F3Y02_RS00060	COG0719	Fe-S assembly protein
F3Y02_RS00070	COG0569	domain protein
F3Y02_RS00075	COG0531	amino acid
F3Y02_RS00100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F3Y02_RS00105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F3Y02_RS00130	COG0708	Exodeoxyribonuclease III
F3Y02_RS00135	COG1028	Short-chain dehydrogenase reductase Sdr
F3Y02_RS00150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3Y02_RS00165	COG3104	oligopeptide transport
F3Y02_RS00170	COG0513	Belongs to the DEAD box helicase family
F3Y02_RS00175	COG0302	gtp cyclohydrolase
F3Y02_RS00195	COG0667	Aldo Keto reductase
F3Y02_RS00205	COG0512	Glutamine amidotransferase of anthranilate synthase
F3Y02_RS00205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F3Y02_RS00210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F3Y02_RS00210	COG0512	Glutamine amidotransferase of anthranilate synthase
F3Y02_RS00220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F3Y02_RS00225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F3Y02_RS00225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F3Y02_RS00245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F3Y02_RS00255	COG0156	8-amino-7-oxononanoate synthase activity
F3Y02_RS00295	COG1472	Belongs to the glycosyl hydrolase 3 family
F3Y02_RS00305	COG0189	ligase activity
F3Y02_RS00350	COG2081	HI0933 family
F3Y02_RS00360	COG0300	oxidoreductase activity
F3Y02_RS00405	COG2918	glutathione biosynthetic process
F3Y02_RS00410	COG0728	peptidoglycan biosynthetic process
F3Y02_RS00420	COG0802	atpase or kinase
F3Y02_RS00425	COG0285	dihydrofolate synthase activity
F3Y02_RS00430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F3Y02_RS00500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F3Y02_RS00510	COG2151	metal-sulfur cluster biosynthetic enzyme
F3Y02_RS00515	COG0316	Belongs to the HesB IscA family
F3Y02_RS00520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F3Y02_RS00525	COG1760	l-serine dehydratase
F3Y02_RS00535	COG1605	Chorismate mutase
F3Y02_RS00535	COG0077	Prephenate dehydratase
F3Y02_RS00550	COG3104	oligopeptide transport
F3Y02_RS00600	COG0751	glycine-tRNA ligase activity
F3Y02_RS00605	COG0084	hydrolase, TatD family'
F3Y02_RS00635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F3Y02_RS00640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F3Y02_RS00670	COG1278	Cold shock
F3Y02_RS00675	COG1509	lysine 2,3-aminomutase activity
F3Y02_RS00755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F3Y02_RS00760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F3Y02_RS00760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F3Y02_RS00785	COG0386	Belongs to the glutathione peroxidase family
F3Y02_RS00820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F3Y02_RS00830	COG0513	Belongs to the DEAD box helicase family
F3Y02_RS00835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F3Y02_RS00840	COG2814	Major facilitator Superfamily
F3Y02_RS00845	COG2814	Major facilitator Superfamily
F3Y02_RS00850	COG1085	galactose-1-phosphate uridylyltransferase
F3Y02_RS00910	COG3397	chitin binding
F3Y02_RS00920	COG0509	glycine decarboxylation via glycine cleavage system
F3Y02_RS00940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F3Y02_RS00960	COG0477	Major facilitator Superfamily
F3Y02_RS00990	COG1446	asparaginase
F3Y02_RS01010	COG0438	transferase activity, transferring glycosyl groups
F3Y02_RS01015	COG1442	glycosyl transferase family 8
F3Y02_RS01015	COG1216	Glycosyl transferase, family 2
F3Y02_RS01020	COG1442	glycosyl transferase family 8
F3Y02_RS01020	COG1216	Glycosyl transferase, family 2
F3Y02_RS01025	COG3475	LICD family
F3Y02_RS01040	COG1132	(ABC) transporter
F3Y02_RS01050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F3Y02_RS01055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F3Y02_RS01060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F3Y02_RS01065	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F3Y02_RS01065	COG0517	IMP dehydrogenase activity
F3Y02_RS01080	COG3220	belongs to the UPF0276 family
F3Y02_RS01105	COG1611	Belongs to the LOG family
F3Y02_RS01140	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F3Y02_RS01145	COG2814	Major facilitator Superfamily
F3Y02_RS01190	COG0813	purine-nucleoside phosphorylase activity
F3Y02_RS01205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F3Y02_RS01225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F3Y02_RS01250	COG0517	IMP dehydrogenase activity
F3Y02_RS01250	COG0516	GMP reductase activity
F3Y02_RS01260	COG0795	lipopolysaccharide-transporting ATPase activity
F3Y02_RS01265	COG0795	lipopolysaccharide-transporting ATPase activity
F3Y02_RS01280	COG0742	ribosomal rna small subunit methyltransferase
F3Y02_RS01285	COG2860	membrane
F3Y02_RS01295	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F3Y02_RS01300	COG0295	cytidine deaminase activity
F3Y02_RS01310	COG0277	FAD linked oxidase domain protein
F3Y02_RS01310	COG0247	lactate metabolic process
F3Y02_RS01325	COG1940	carbohydrate kinase activity
F3Y02_RS01345	COG4988	ABC transporter
F3Y02_RS01350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F3Y02_RS01360	COG0251	oxidation-reduction process
F3Y02_RS01365	COG0659	secondary active sulfate transmembrane transporter activity
F3Y02_RS01380	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F3Y02_RS01415	COG2271	Major facilitator Superfamily
F3Y02_RS01420	COG0584	glycerophosphoryl diester phosphodiesterase
F3Y02_RS01430	COG1131	(ABC) transporter
F3Y02_RS01440	COG0842	Transport permease protein
F3Y02_RS01470	COG0156	8-amino-7-oxononanoate synthase activity
F3Y02_RS01480	COG0814	amino acid
F3Y02_RS01485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F3Y02_RS01490	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F3Y02_RS01510	COG1940	carbohydrate kinase activity
F3Y02_RS01565	COG3116	cell division
F3Y02_RS01575	COG0318	PFAM AMP-dependent synthetase and ligase
F3Y02_RS01575	COG0204	Acyl-transferase
F3Y02_RS01580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F3Y02_RS01610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F3Y02_RS01640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F3Y02_RS01650	COG0628	permease
F3Y02_RS01665	COG1446	asparaginase
F3Y02_RS01685	COG2814	Major facilitator Superfamily
F3Y02_RS01690	COG0583	DNA-binding transcription factor activity
F3Y02_RS01695	COG0546	phosphoglycolate phosphatase activity
F3Y02_RS01705	COG0492	ferredoxin-NADP+ reductase activity
F3Y02_RS01725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F3Y02_RS01740	COG1162	GTPase activity
F3Y02_RS01755	COG0531	amino acid
F3Y02_RS01765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F3Y02_RS01770	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F3Y02_RS01770	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F3Y02_RS01800	COG0439	Biotin carboxylase
F3Y02_RS01815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F3Y02_RS01825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F3Y02_RS01845	COG0252	asparaginase activity
F3Y02_RS01850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F3Y02_RS01855	COG0113	porphobilinogen synthase activity
F3Y02_RS01865	COG0470	DNA polymerase III
F3Y02_RS01870	COG0616	signal peptide processing
F3Y02_RS01875	COG0625	glutathione transferase activity
F3Y02_RS01880	COG2920	part of a sulfur-relay system
F3Y02_RS01890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F3Y02_RS01905	COG0463	Glycosyl transferase, family 2
F3Y02_RS01915	COG0772	Belongs to the SEDS family
F3Y02_RS01930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F3Y02_RS01935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F3Y02_RS02010	COG0583	DNA-binding transcription factor activity
F3Y02_RS02025	COG2853	Lipoprotein
F3Y02_RS02045	COG0531	amino acid
F3Y02_RS02080	COG2814	Major facilitator Superfamily
F3Y02_RS02095	COG0601	transmembrane transport
F3Y02_RS02100	COG0601	transmembrane transport
F3Y02_RS02115	COG0210	DNA helicase
F3Y02_RS02120	COG0552	protein localization to endoplasmic reticulum
F3Y02_RS02140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F3Y02_RS02145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F3Y02_RS02150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F3Y02_RS02155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F3Y02_RS02165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3Y02_RS02165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F3Y02_RS02190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3Y02_RS02195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F3Y02_RS02215	COG1619	proteins homologs of microcin C7 resistance protein MccF
F3Y02_RS02245	COG2890	protein-(glutamine-N5) methyltransferase activity
F3Y02_RS02250	COG2814	Major facilitator Superfamily
F3Y02_RS02255	COG0456	acetyltransferase
F3Y02_RS02310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F3Y02_RS02315	COG1494	fructose-1,6-bisphosphatase
F3Y02_RS02320	COG2945	thiolester hydrolase activity
F3Y02_RS02325	COG0833	amino acid
F3Y02_RS02335	COG1674	ftsk spoiiie
F3Y02_RS02350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F3Y02_RS02375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F3Y02_RS02425	COG2890	protein-(glutamine-N5) methyltransferase activity
F3Y02_RS02445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3Y02_RS02450	COG2814	Major facilitator Superfamily
F3Y02_RS02460	COG3023	N-Acetylmuramoyl-L-alanine amidase
F3Y02_RS02495	COG4974	Belongs to the 'phage' integrase family
F3Y02_RS02575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F3Y02_RS02605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F3Y02_RS02620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F3Y02_RS02655	COG0642	Histidine kinase
F3Y02_RS02660	COG1090	epimerase
F3Y02_RS02675	COG1271	oxidase subunit
F3Y02_RS02680	COG1294	oxidase, subunit
F3Y02_RS02715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F3Y02_RS02740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F3Y02_RS02775	COG1053	succinate dehydrogenase
F3Y02_RS02780	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F3Y02_RS02795	COG2223	nitrite transmembrane transporter activity
F3Y02_RS02810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F3Y02_RS02870	COG0564	pseudouridine synthase activity
F3Y02_RS02875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F3Y02_RS02900	COG2251	uridine kinase activity
F3Y02_RS02900	COG0195	Participates in both transcription termination and antitermination
F3Y02_RS02960	COG0839	Belongs to the complex I subunit 6 family
F3Y02_RS02975	COG1034	ATP synthesis coupled electron transport
F3Y02_RS02985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F3Y02_RS03005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F3Y02_RS03015	COG4264	IucA IucC family
F3Y02_RS03020	COG2814	Major facilitator Superfamily
F3Y02_RS03025	COG0019	diaminopimelate decarboxylase activity
F3Y02_RS03030	COG2814	Major facilitator Superfamily
F3Y02_RS03060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F3Y02_RS03080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F3Y02_RS03120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F3Y02_RS03135	COG1538	Outer membrane efflux protein
F3Y02_RS03155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F3Y02_RS03165	COG0531	amino acid
F3Y02_RS03175	COG0814	amino acid
F3Y02_RS03205	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F3Y02_RS03250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F3Y02_RS03275	COG0814	amino acid
F3Y02_RS03285	COG3040	lipid binding
F3Y02_RS03300	COG2066	Belongs to the glutaminase family
F3Y02_RS03310	COG2862	Uncharacterized protein family, UPF0114
F3Y02_RS03315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F3Y02_RS03325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F3Y02_RS03345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F3Y02_RS03365	COG0009	L-threonylcarbamoyladenylate synthase
F3Y02_RS03375	COG0204	Acyl-transferase
F3Y02_RS03380	COG0658	competence protein
F3Y02_RS03380	COG2333	competence protein COMEC
F3Y02_RS03400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
F3Y02_RS03435	COG0138	bifunctional purine biosynthesis protein purh
F3Y02_RS03460	COG1121	(ABC) transporter
F3Y02_RS03485	COG1295	ribonuclease BN
F3Y02_RS03495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F3Y02_RS03515	COG0488	(ABC) transporter
F3Y02_RS03560	COG0308	aminopeptidase N
F3Y02_RS03565	COG0071	Belongs to the small heat shock protein (HSP20) family
F3Y02_RS03570	COG0134	indole-3-glycerol-phosphate synthase activity
F3Y02_RS03570	COG0135	phosphoribosylanthranilate isomerase activity
F3Y02_RS03580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3Y02_RS03605	COG0512	Glutamine amidotransferase of anthranilate synthase
F3Y02_RS03610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F3Y02_RS03630	COG1530	ribonuclease E activity
F3Y02_RS03645	COG0477	Major facilitator Superfamily
F3Y02_RS03680	COG0425	Belongs to the sulfur carrier protein TusA family
F3Y02_RS03680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3Y02_RS03695	COG2137	regulation of response to DNA damage stimulus
F3Y02_RS03700	COG0629	single-stranded DNA binding
F3Y02_RS03710	COG0280	phosphate acetyltransferase
F3Y02_RS03710	COG0857	belongs to the CobB CobQ family
F3Y02_RS03745	COG1012	belongs to the aldehyde dehydrogenase family
F3Y02_RS03765	COG0814	amino acid
F3Y02_RS03780	COG0540	Belongs to the ATCase OTCase family
F3Y02_RS03785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F3Y02_RS03790	COG0505	Belongs to the CarA family
F3Y02_RS03835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F3Y02_RS03845	COG0583	DNA-binding transcription factor activity
F3Y02_RS03880	COG0287	Prephenate dehydrogenase
F3Y02_RS03880	COG1605	Chorismate mutase
F3Y02_RS03885	COG0287	Prephenate dehydrogenase
F3Y02_RS03885	COG1605	Chorismate mutase
F3Y02_RS03900	COG1621	beta-fructofuranosidase activity
F3Y02_RS03915	COG0778	Nitroreductase
F3Y02_RS03925	COG0814	amino acid
F3Y02_RS03950	COG2814	Major facilitator Superfamily
F3Y02_RS03960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F3Y02_RS03965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3Y02_RS03990	COG0242	peptide deformylase activity
F3Y02_RS04000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3Y02_RS04000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F3Y02_RS04010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F3Y02_RS04010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F3Y02_RS04050	COG0204	Acyl-transferase
F3Y02_RS04060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F3Y02_RS04085	COG0542	response to heat
F3Y02_RS04110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F3Y02_RS04135	COG3201	nicotinamide mononucleotide transporter
F3Y02_RS04145	COG0738	Major facilitator superfamily
F3Y02_RS04290	COG0574	Belongs to the PEP-utilizing enzyme family
F3Y02_RS04290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F3Y02_RS04295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F3Y02_RS04325	COG0557	exoribonuclease II activity
F3Y02_RS04365	COG1116	anion transmembrane transporter activity
F3Y02_RS04380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F3Y02_RS04430	COG1984	allophanate hydrolase subunit 2
F3Y02_RS04465	COG0589	response to stress
F3Y02_RS04490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F3Y02_RS04500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F3Y02_RS04515	COG0594	ribonuclease P activity
F3Y02_RS04530	COG1560	Kdo2-lipid A biosynthetic process
F3Y02_RS04535	COG1560	Kdo2-lipid A biosynthetic process
F3Y02_RS04565	COG2814	Major facilitator Superfamily
F3Y02_RS04570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F3Y02_RS04580	COG1294	oxidase, subunit
F3Y02_RS04585	COG1271	oxidase subunit
F3Y02_RS04590	COG2814	Major facilitator Superfamily
F3Y02_RS04595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F3Y02_RS04600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F3Y02_RS04610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F3Y02_RS04630	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F3Y02_RS04640	COG0714	Associated with various cellular activities
F3Y02_RS04660	COG2304	oxidoreductase activity
F3Y02_RS04675	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
F3Y02_RS04690	COG0525	valine-tRNA ligase activity
F3Y02_RS04725	COG0114	fumarate hydratase activity
F3Y02_RS04745	COG0531	amino acid
F3Y02_RS04760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F3Y02_RS04785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F3Y02_RS04790	COG0575	Belongs to the CDS family
F3Y02_RS04800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F3Y02_RS04925	COG0201	protein transport
F3Y02_RS04965	COG3335	DDE superfamily endonuclease
F3Y02_RS04995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F3Y02_RS05015	COG0531	amino acid
F3Y02_RS05025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F3Y02_RS05030	COG0398	Pfam SNARE associated Golgi protein
F3Y02_RS05035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3Y02_RS05040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F3Y02_RS05050	COG0531	amino acid
F3Y02_RS05065	COG0814	amino acid
F3Y02_RS05080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F3Y02_RS05105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F3Y02_RS05110	COG0814	amino acid
F3Y02_RS05150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F3Y02_RS05185	COG0180	Tryptophanyl-tRNA synthetase
F3Y02_RS05200	COG0237	dephospho-CoA kinase activity
F3Y02_RS05215	COG0508	dehydrogenase complex catalyzes the overall conversion of
F3Y02_RS05220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F3Y02_RS05235	COG1051	belongs to the nudix hydrolase family
F3Y02_RS05290	COG4401	Chorismate mutase type I
F3Y02_RS05295	COG1183	phosphatidylcholine synthase activity
F3Y02_RS05305	COG0811	peptide transport
F3Y02_RS05370	COG0385	Bile acid
F3Y02_RS05400	COG2363	Small membrane protein
F3Y02_RS05450	COG1704	LemA family
F3Y02_RS05525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3Y02_RS05525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3Y02_RS05540	COG0833	amino acid
F3Y02_RS05555	COG0436	Aminotransferase
F3Y02_RS05565	COG0497	DNA recombination
F3Y02_RS05580	COG4969	Belongs to the N-Me-Phe pilin family
F3Y02_RS05585	COG0671	phosphoesterase, PA-phosphatase related
F3Y02_RS05595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F3Y02_RS05605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F3Y02_RS05630	COG0009	L-threonylcarbamoyladenylate synthase
F3Y02_RS05635	COG2917	probably involved in intracellular septation
F3Y02_RS05645	COG0837	glucose binding
F3Y02_RS05660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F3Y02_RS05665	COG0537	adenosine 5'-monophosphoramidase activity
F3Y02_RS05670	COG1040	competence protein
F3Y02_RS05675	COG2226	methyltransferase
F3Y02_RS05685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F3Y02_RS05690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F3Y02_RS05720	COG0339	signal peptide processing
F3Y02_RS05760	COG1192	Involved in chromosome partitioning
F3Y02_RS05765	COG1475	DNA binding
F3Y02_RS05770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F3Y02_RS05770	COG0519	Catalyzes the synthesis of GMP from XMP
F3Y02_RS05805	COG0196	riboflavin kinase activity
F3Y02_RS05810	COG0281	malic enzyme
F3Y02_RS05835	COG1739	Uncharacterized protein family UPF0029
F3Y02_RS05840	COG2271	Major facilitator Superfamily
F3Y02_RS05900	COG1994	Peptidase M50
F3Y02_RS05920	COG1051	belongs to the nudix hydrolase family
F3Y02_RS05920	COG1056	cytidyltransferase-related domain
F3Y02_RS05930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3Y02_RS05970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F3Y02_RS05975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F3Y02_RS05990	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F3Y02_RS06020	COG0587	DNA-directed DNA polymerase activity
F3Y02_RS06025	COG0242	peptide deformylase activity
F3Y02_RS06045	COG1982	Orn Lys Arg decarboxylase major
F3Y02_RS06055	COG0509	glycine decarboxylation via glycine cleavage system
F3Y02_RS06075	COG1523	belongs to the glycosyl hydrolase 13 family
F3Y02_RS06085	COG0033	Phosphoglucomutase
F3Y02_RS06100	COG0058	SHG alpha-glucan phosphorylase activity
F3Y02_RS06105	COG1640	4-alpha-glucanotransferase
F3Y02_RS06115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3Y02_RS06125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F3Y02_RS06135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F3Y02_RS06150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F3Y02_RS06160	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F3Y02_RS06200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F3Y02_RS06205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F3Y02_RS06210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3Y02_RS06240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F3Y02_RS06245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F3Y02_RS06250	COG1127	ABC transporter
F3Y02_RS06265	COG0850	regulation of cytokinetic process
F3Y02_RS06285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F3Y02_RS06295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F3Y02_RS06345	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3Y02_RS06365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F3Y02_RS06385	COG1472	Belongs to the glycosyl hydrolase 3 family
F3Y02_RS06400	COG1183	phosphatidylcholine synthase activity
F3Y02_RS06405	COG0142	geranyltranstransferase activity
F3Y02_RS06410	COG1519	Transferase
F3Y02_RS06415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F3Y02_RS06420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F3Y02_RS06425	COG2828	Protein conserved in bacteria
F3Y02_RS06430	COG2828	Protein conserved in bacteria
F3Y02_RS06435	COG0745	RESPONSE REGULATOR receiver
F3Y02_RS06440	COG0681	Belongs to the peptidase S26 family
F3Y02_RS06455	COG0557	exoribonuclease II activity
F3Y02_RS06480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F3Y02_RS06570	COG2814	Major facilitator Superfamily
F3Y02_RS06580	COG0183	Belongs to the thiolase family
F3Y02_RS06585	COG1250	3-hydroxyacyl-CoA dehydrogenase
F3Y02_RS06585	COG1024	Enoyl-CoA hydratase
F3Y02_RS06590	COG1960	acyl-CoA dehydrogenase activity
F3Y02_RS06595	COG0318	PFAM AMP-dependent synthetase and ligase
F3Y02_RS06600	COG1393	Belongs to the ArsC family
F3Y02_RS06615	COG1643	Atp-dependent helicase
F3Y02_RS06625	COG1086	Polysaccharide biosynthesis protein
F3Y02_RS06630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F3Y02_RS06650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F3Y02_RS06665	COG0367	asparagine synthase
F3Y02_RS06685	COG1215	transferase activity, transferring glycosyl groups
F3Y02_RS06690	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F3Y02_RS06695	COG1088	dTDP-glucose 4,6-dehydratase activity
F3Y02_RS06705	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
F3Y02_RS06705	COG0662	Cupin 2, conserved barrel domain protein
F3Y02_RS06720	COG3118	belongs to the thioredoxin family
F3Y02_RS06725	COG0248	Ppx GppA phosphatase
F3Y02_RS06760	COG0084	hydrolase, TatD family'
F3Y02_RS06765	COG0730	response to heat
F3Y02_RS06775	COG1131	(ABC) transporter
F3Y02_RS06780	COG0842	Transport permease protein
F3Y02_RS06785	COG0463	Glycosyl transferase, family 2
F3Y02_RS06795	COG1280	lysine exporter protein (LysE YggA)
F3Y02_RS06825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3Y02_RS06850	COG2983	Belongs to the UPF0260 family
F3Y02_RS06920	COG2166	iron-sulfur cluster assembly
F3Y02_RS06985	COG0697	spore germination
F3Y02_RS06990	COG0069	glutamate synthase activity
F3Y02_RS06995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F3Y02_RS07010	COG1074	ATP-dependent DNA helicase activity
F3Y02_RS07015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F3Y02_RS07065	COG1177	transmembrane transport
F3Y02_RS07070	COG1176	ABC-type spermidine putrescine transport system, permease component I
F3Y02_RS07075	COG3842	ATPase activity
F3Y02_RS07100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F3Y02_RS07115	COG0477	Major facilitator Superfamily
F3Y02_RS07125	COG0318	PFAM AMP-dependent synthetase and ligase
F3Y02_RS07135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F3Y02_RS07155	COG1127	ABC transporter
F3Y02_RS07160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F3Y02_RS07165	COG2992	FlgJ-related protein
F3Y02_RS07170	COG0564	pseudouridine synthase activity
F3Y02_RS07175	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F3Y02_RS07195	COG3028	Belongs to the UPF0307 family
F3Y02_RS07240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F3Y02_RS07255	COG1530	ribonuclease E activity
F3Y02_RS07275	COG0586	Pfam SNARE associated Golgi protein
F3Y02_RS07280	COG0586	Pfam SNARE associated Golgi protein
F3Y02_RS07300	COG3079	Belongs to the UPF0149 family
F3Y02_RS07305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3Y02_RS07310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F3Y02_RS07330	COG0561	phosphatase activity
F3Y02_RS07335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F3Y02_RS07340	COG0346	lactoylglutathione lyase activity
F3Y02_RS07400	COG4221	oxidoreductase activity
F3Y02_RS07405	COG2925	Exonuclease
F3Y02_RS07410	COG0556	nucleotide-excision repair
F3Y02_RS07425	COG0477	Major facilitator Superfamily
F3Y02_RS07435	COG2308	Evidence 4 Homologs of previously reported genes of
F3Y02_RS07485	COG2867	negative regulation of translational initiation
F3Y02_RS07490	COG2914	Belongs to the UPF0125 (RnfH) family
F3Y02_RS07495	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F3Y02_RS07495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3Y02_RS07505	COG0405	Gamma-glutamyltransferase
F3Y02_RS07580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F3Y02_RS07585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F3Y02_RS07590	COG1214	PFAM Peptidase M22, glycoprotease
F3Y02_RS07600	COG0436	Aminotransferase
F3Y02_RS07605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F3Y02_RS07675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F3Y02_RS07685	COG0531	amino acid
F3Y02_RS07690	COG2814	Major facilitator Superfamily
F3Y02_RS07695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F3Y02_RS07715	COG1028	Short-chain dehydrogenase reductase Sdr
F3Y02_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
F3Y02_RS07785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F3Y02_RS07800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3Y02_RS07800	COG0189	ligase activity
F3Y02_RS07805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F3Y02_RS07805	COG1181	Belongs to the D-alanine--D-alanine ligase family
F3Y02_RS07815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F3Y02_RS07825	COG1464	Belongs to the NlpA lipoprotein family
F3Y02_RS07870	COG1335	isochorismatase
F3Y02_RS07880	COG1862	Preprotein translocase
F3Y02_RS07885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3Y02_RS07890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F3Y02_RS07900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F3Y02_RS07905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F3Y02_RS07920	COG0252	asparaginase activity
F3Y02_RS07925	COG0288	reversible hydration of carbon dioxide
F3Y02_RS07935	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F3Y02_RS07940	COG1773	rubredoxin
F3Y02_RS07965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F3Y02_RS07970	COG2814	Major facilitator Superfamily
F3Y02_RS08050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F3Y02_RS08055	COG4535	Mg2 and Co2 transporter CorC
F3Y02_RS08065	COG1702	phosphate starvation-inducible protein PhoH
F3Y02_RS08075	COG4122	O-methyltransferase activity
F3Y02_RS08105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F3Y02_RS08110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F3Y02_RS08135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F3Y02_RS08145	COG0330	HflC and HflK could
F3Y02_RS08150	COG0330	HflC and HflK could
F3Y02_RS08155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F3Y02_RS08175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F3Y02_RS08195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F3Y02_RS08200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F3Y02_RS08205	COG0670	Belongs to the BI1 family
F3Y02_RS08220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F3Y02_RS08225	COG2878	Part of a membrane complex involved in electron transport
F3Y02_RS08230	COG2999	glutathione oxidoreductase activity
F3Y02_RS08240	COG1528	Iron-storage protein
F3Y02_RS08250	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F3Y02_RS08265	COG2271	Major facilitator Superfamily
F3Y02_RS08300	COG0076	glutamate decarboxylase activity
F3Y02_RS08360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F3Y02_RS08370	COG4536	flavin adenine dinucleotide binding
F3Y02_RS08385	COG0012	GTP binding
F3Y02_RS08405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F3Y02_RS08420	COG3104	oligopeptide transport
F3Y02_RS08430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F3Y02_RS08440	COG0095	Lipoate-protein ligase
F3Y02_RS08445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F3Y02_RS08460	COG0277	FAD linked oxidase domain protein
F3Y02_RS08470	COG1979	alcohol dehydrogenase
F3Y02_RS08475	COG2264	protein methyltransferase activity
F3Y02_RS08480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F3Y02_RS08490	COG2852	Protein conserved in bacteria
F3Y02_RS08525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F3Y02_RS08580	COG0450	alkyl hydroperoxide reductase
F3Y02_RS08615	COG1876	peptidase activity
F3Y02_RS08640	COG1937	Protein conserved in bacteria
F3Y02_RS08650	COG0583	DNA-binding transcription factor activity
F3Y02_RS08735	COG1187	pseudouridine synthase activity
F3Y02_RS08790	COG0142	geranyltranstransferase activity
F3Y02_RS08815	COG2027	D-alanyl-D-alanine carboxypeptidase
F3Y02_RS08825	COG1610	YqeY-like protein
F3Y02_RS08830	COG0358	DNA primase activity
F3Y02_RS08860	COG2921	Belongs to the UPF0250 family
F3Y02_RS08865	COG1686	Belongs to the peptidase S11 family
F3Y02_RS08870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F3Y02_RS08875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F3Y02_RS08890	COG1137	ATPase activity
F3Y02_RS08895	COG0179	Fumarylacetoacetate (FAA) hydrolase
F3Y02_RS08900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F3Y02_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
F3Y02_RS08960	COG3655	Transcriptional regulator
F3Y02_RS09000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F3Y02_RS09010	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F3Y02_RS09015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F3Y02_RS09070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F3Y02_RS09075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F3Y02_RS09110	COG0354	folic acid binding
F3Y02_RS09115	COG0210	DNA helicase
F3Y02_RS09120	COG2996	Protein conserved in bacteria
F3Y02_RS09130	COG2974	May be involved in recombination
F3Y02_RS09165	COG3550	peptidyl-serine autophosphorylation
F3Y02_RS09170	COG1396	sequence-specific DNA binding
F3Y02_RS09205	COG0483	inositol monophosphate 1-phosphatase activity
F3Y02_RS09210	COG2855	membrane
F3Y02_RS09220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F3Y02_RS09220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F3Y02_RS09230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F3Y02_RS09240	COG1028	Short-chain dehydrogenase reductase Sdr
F3Y02_RS09245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F3Y02_RS09285	COG0469	pyruvate kinase activity
F3Y02_RS09290	COG0191	fructose-bisphosphate aldolase activity
F3Y02_RS09310	COG0738	Major facilitator superfamily
F3Y02_RS09430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F3Y02_RS09500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F3Y02_RS09515	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F3Y02_RS09535	COG0583	DNA-binding transcription factor activity
F3Y02_RS09550	COG0697	spore germination
F3Y02_RS09560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F3Y02_RS09560	COG0072	phenylalanine-tRNA ligase activity
F3Y02_RS09565	COG0735	belongs to the Fur family
F3Y02_RS09570	COG0523	cobalamin synthesis protein
F3Y02_RS09585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F3Y02_RS09590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F3Y02_RS09600	COG0489	protein tyrosine kinase activity