locus-tag	class	description
DA46_RS00035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DA46_RS00040	COG1074	ATP-dependent DNA helicase activity
DA46_RS00055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DA46_RS00060	COG0069	glutamate synthase activity
DA46_RS00065	COG0697	spore germination
DA46_RS00130	COG2166	iron-sulfur cluster assembly
DA46_RS00200	COG2983	Belongs to the UPF0260 family
DA46_RS00225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA46_RS00240	COG3335	DDE superfamily endonuclease
DA46_RS00260	COG1280	lysine exporter protein (LysE YggA)
DA46_RS00270	COG0463	Glycosyl transferase, family 2
DA46_RS00275	COG0842	Transport permease protein
DA46_RS00280	COG1131	(ABC) transporter
DA46_RS00290	COG0730	response to heat
DA46_RS00300	COG0084	hydrolase, TatD family'
DA46_RS00325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DA46_RS00340	COG0248	Ppx GppA phosphatase
DA46_RS00345	COG3118	belongs to the thioredoxin family
DA46_RS00360	COG0662	Cupin 2, conserved barrel domain protein
DA46_RS00360	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DA46_RS00365	COG3335	DDE superfamily endonuclease
DA46_RS00375	COG1088	dTDP-glucose 4,6-dehydratase activity
DA46_RS00380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DA46_RS00385	COG1215	transferase activity, transferring glycosyl groups
DA46_RS00405	COG0367	asparagine synthase
DA46_RS00420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA46_RS00440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DA46_RS00445	COG1086	Polysaccharide biosynthesis protein
DA46_RS00455	COG1643	Atp-dependent helicase
DA46_RS00470	COG1393	Belongs to the ArsC family
DA46_RS00475	COG0318	PFAM AMP-dependent synthetase and ligase
DA46_RS00480	COG1960	acyl-CoA dehydrogenase activity
DA46_RS00485	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA46_RS00485	COG1024	Enoyl-CoA hydratase
DA46_RS00490	COG0183	Belongs to the thiolase family
DA46_RS00580	COG5002	protein histidine kinase activity
DA46_RS00600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DA46_RS00625	COG0557	exoribonuclease II activity
DA46_RS00640	COG0681	Belongs to the peptidase S26 family
DA46_RS00650	COG2828	Protein conserved in bacteria
DA46_RS00655	COG2828	Protein conserved in bacteria
DA46_RS00660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DA46_RS00665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DA46_RS00670	COG1519	Transferase
DA46_RS00675	COG0142	geranyltranstransferase activity
DA46_RS00680	COG1183	phosphatidylcholine synthase activity
DA46_RS00695	COG1472	Belongs to the glycosyl hydrolase 3 family
DA46_RS00715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DA46_RS00735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA46_RS00785	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DA46_RS00790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DA46_RS00810	COG0850	regulation of cytokinetic process
DA46_RS00825	COG1127	ABC transporter
DA46_RS00830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DA46_RS00835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DA46_RS00865	COG3335	DDE superfamily endonuclease
DA46_RS00870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA46_RS00875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DA46_RS00880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DA46_RS00920	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DA46_RS00925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DA46_RS00930	COG0083	homoserine kinase activity
DA46_RS00950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DA46_RS00960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DA46_RS00970	COG1640	4-alpha-glucanotransferase
DA46_RS00975	COG0058	SHG alpha-glucan phosphorylase activity
DA46_RS00990	COG0033	Phosphoglucomutase
DA46_RS01000	COG1523	belongs to the glycosyl hydrolase 13 family
DA46_RS01020	COG0509	glycine decarboxylation via glycine cleavage system
DA46_RS01030	COG1982	Orn Lys Arg decarboxylase major
DA46_RS01050	COG0242	peptide deformylase activity
DA46_RS01055	COG0587	DNA-directed DNA polymerase activity
DA46_RS01080	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DA46_RS01095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DA46_RS01100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA46_RS01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DA46_RS01150	COG1056	cytidyltransferase-related domain
DA46_RS01150	COG1051	belongs to the nudix hydrolase family
DA46_RS01170	COG1994	Peptidase M50
DA46_RS01230	COG2271	Major facilitator Superfamily
DA46_RS01235	COG1739	Uncharacterized protein family UPF0029
DA46_RS01250	COG3335	DDE superfamily endonuclease
DA46_RS01270	COG0281	malic enzyme
DA46_RS01275	COG0196	riboflavin kinase activity
DA46_RS01310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DA46_RS01310	COG0519	Catalyzes the synthesis of GMP from XMP
DA46_RS01315	COG1475	DNA binding
DA46_RS01320	COG1192	Involved in chromosome partitioning
DA46_RS01360	COG0339	signal peptide processing
DA46_RS01390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA46_RS01395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DA46_RS01405	COG2226	methyltransferase
DA46_RS01410	COG1040	competence protein
DA46_RS01420	COG0537	adenosine 5'-monophosphoramidase activity
DA46_RS01425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DA46_RS01440	COG0837	glucose binding
DA46_RS01450	COG2917	probably involved in intracellular septation
DA46_RS01455	COG0009	L-threonylcarbamoyladenylate synthase
DA46_RS01475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DA46_RS01485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DA46_RS01495	COG0671	phosphoesterase, PA-phosphatase related
DA46_RS01500	COG4969	Belongs to the N-Me-Phe pilin family
DA46_RS01520	COG0497	DNA recombination
DA46_RS01530	COG0436	Aminotransferase
DA46_RS01545	COG0833	amino acid
DA46_RS01560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA46_RS01560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA46_RS01640	COG1704	LemA family
DA46_RS01690	COG3335	DDE superfamily endonuclease
DA46_RS01695	COG2363	Small membrane protein
DA46_RS01725	COG0385	Bile acid
DA46_RS01735	COG3046	protein related to deoxyribodipyrimidine photolyase
DA46_RS01740	COG0415	Belongs to the DNA photolyase family
DA46_RS01745	COG0415	Belongs to the DNA photolyase family
DA46_RS01755	COG3335	DDE superfamily endonuclease
DA46_RS01765	COG0456	acetyltransferase
DA46_RS01800	COG0811	peptide transport
DA46_RS01810	COG1183	phosphatidylcholine synthase activity
DA46_RS01815	COG4401	Chorismate mutase type I
DA46_RS01870	COG1051	belongs to the nudix hydrolase family
DA46_RS01875	COG3335	DDE superfamily endonuclease
DA46_RS01885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA46_RS01890	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA46_RS01905	COG0237	dephospho-CoA kinase activity
DA46_RS01920	COG0180	Tryptophanyl-tRNA synthetase
DA46_RS01955	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DA46_RS02000	COG0814	amino acid
DA46_RS02005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DA46_RS02030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA46_RS02040	COG0814	amino acid
DA46_RS02055	COG0531	amino acid
DA46_RS02065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DA46_RS02070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA46_RS02075	COG0398	Pfam SNARE associated Golgi protein
DA46_RS02080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA46_RS02090	COG0531	amino acid
DA46_RS02110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA46_RS02120	COG3335	DDE superfamily endonuclease
DA46_RS02135	COG3335	DDE superfamily endonuclease
DA46_RS02150	COG3335	DDE superfamily endonuclease
DA46_RS02190	COG0201	protein transport
DA46_RS02315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DA46_RS02325	COG0575	Belongs to the CDS family
DA46_RS02330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DA46_RS02355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DA46_RS02370	COG0531	amino acid
DA46_RS02390	COG0114	fumarate hydratase activity
DA46_RS02405	COG1304	FMN binding
DA46_RS02425	COG0525	valine-tRNA ligase activity
DA46_RS02440	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DA46_RS02455	COG2304	oxidoreductase activity
DA46_RS02475	COG0714	Associated with various cellular activities
DA46_RS02485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DA46_RS02505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DA46_RS02515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA46_RS02520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA46_RS02525	COG2814	Major facilitator Superfamily
DA46_RS02530	COG1271	oxidase subunit
DA46_RS02535	COG1294	oxidase, subunit
DA46_RS02545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA46_RS02550	COG2814	Major facilitator Superfamily
DA46_RS02555	COG3335	DDE superfamily endonuclease
DA46_RS02570	COG0589	response to stress
DA46_RS02595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DA46_RS02605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DA46_RS02620	COG0594	ribonuclease P activity
DA46_RS02635	COG1560	Kdo2-lipid A biosynthetic process
DA46_RS02640	COG1560	Kdo2-lipid A biosynthetic process
DA46_RS02670	COG3335	DDE superfamily endonuclease
DA46_RS02695	COG1984	allophanate hydrolase subunit 2
DA46_RS02730	COG3335	DDE superfamily endonuclease
DA46_RS02760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DA46_RS02775	COG1116	anion transmembrane transporter activity
DA46_RS02820	COG0557	exoribonuclease II activity
DA46_RS02845	COG3335	DDE superfamily endonuclease
DA46_RS02855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DA46_RS02860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DA46_RS02860	COG0574	Belongs to the PEP-utilizing enzyme family
DA46_RS02875	COG3335	DDE superfamily endonuclease
DA46_RS03005	COG0738	Major facilitator superfamily
DA46_RS03010	COG3335	DDE superfamily endonuclease
DA46_RS03020	COG3201	nicotinamide mononucleotide transporter
DA46_RS03045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DA46_RS03070	COG0542	response to heat
DA46_RS03095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DA46_RS03105	COG0204	Acyl-transferase
DA46_RS03140	COG3335	DDE superfamily endonuclease
DA46_RS03150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA46_RS03150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA46_RS03160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA46_RS03160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA46_RS03170	COG0242	peptide deformylase activity
DA46_RS03195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA46_RS03200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DA46_RS03210	COG2814	Major facilitator Superfamily
DA46_RS03235	COG0814	amino acid
DA46_RS03245	COG0778	Nitroreductase
DA46_RS03260	COG3335	DDE superfamily endonuclease
DA46_RS03265	COG1621	beta-fructofuranosidase activity
DA46_RS03280	COG0287	Prephenate dehydrogenase
DA46_RS03280	COG1605	Chorismate mutase
DA46_RS03285	COG1605	Chorismate mutase
DA46_RS03285	COG0287	Prephenate dehydrogenase
DA46_RS03295	COG0284	orotidine-5'-phosphate decarboxylase activity
DA46_RS03320	COG0583	DNA-binding transcription factor activity
DA46_RS03330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA46_RS03375	COG0505	Belongs to the CarA family
DA46_RS03380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA46_RS03385	COG0540	Belongs to the ATCase OTCase family
DA46_RS03400	COG0814	amino acid
DA46_RS03405	COG3335	DDE superfamily endonuclease
DA46_RS03440	COG3335	DDE superfamily endonuclease
DA46_RS03450	COG0280	phosphate acetyltransferase
DA46_RS03450	COG0857	belongs to the CobB CobQ family
DA46_RS03460	COG0629	single-stranded DNA binding
DA46_RS03465	COG2137	regulation of response to DNA damage stimulus
DA46_RS03480	COG0425	Belongs to the sulfur carrier protein TusA family
DA46_RS03480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA46_RS03500	COG3961	Belongs to the TPP enzyme family
DA46_RS03515	COG3335	DDE superfamily endonuclease
DA46_RS03520	COG0477	Major facilitator Superfamily
DA46_RS03555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA46_RS03560	COG0512	Glutamine amidotransferase of anthranilate synthase
DA46_RS03585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA46_RS03595	COG0135	phosphoribosylanthranilate isomerase activity
DA46_RS03595	COG0134	indole-3-glycerol-phosphate synthase activity
DA46_RS03600	COG0071	Belongs to the small heat shock protein (HSP20) family
DA46_RS03605	COG0308	aminopeptidase N
DA46_RS03650	COG0488	(ABC) transporter
DA46_RS03660	COG3335	DDE superfamily endonuclease
DA46_RS03670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DA46_RS03680	COG1295	ribonuclease BN
DA46_RS03705	COG1121	(ABC) transporter
DA46_RS03730	COG0138	bifunctional purine biosynthesis protein purh
DA46_RS03740	COG3293	Transposase
DA46_RS03750	COG3335	DDE superfamily endonuclease
DA46_RS03770	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DA46_RS03785	COG1181	Belongs to the D-alanine--D-alanine ligase family
DA46_RS03800	COG0204	Acyl-transferase
DA46_RS03810	COG0009	L-threonylcarbamoyladenylate synthase
DA46_RS03830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DA46_RS03850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DA46_RS03860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DA46_RS03865	COG2862	Uncharacterized protein family, UPF0114
DA46_RS03875	COG2066	Belongs to the glutaminase family
DA46_RS03890	COG3040	lipid binding
DA46_RS03910	COG3335	DDE superfamily endonuclease
DA46_RS03920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DA46_RS03940	COG3335	DDE superfamily endonuclease
DA46_RS03970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DA46_RS04000	COG0814	amino acid
DA46_RS04010	COG0531	amino acid
DA46_RS04020	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DA46_RS04030	COG0826	peptidase U32
DA46_RS04040	COG1538	Outer membrane efflux protein
DA46_RS04055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DA46_RS04060	COG0047	phosphoribosylformylglycinamidine synthase activity
DA46_RS04060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DA46_RS04110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA46_RS04130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DA46_RS04165	COG2814	Major facilitator Superfamily
DA46_RS04170	COG0019	diaminopimelate decarboxylase activity
DA46_RS04175	COG2814	Major facilitator Superfamily
DA46_RS04180	COG4264	IucA IucC family
DA46_RS04190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA46_RS04210	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DA46_RS04220	COG1034	ATP synthesis coupled electron transport
DA46_RS04235	COG0839	Belongs to the complex I subunit 6 family
DA46_RS04270	COG3335	DDE superfamily endonuclease
DA46_RS04295	COG2251	uridine kinase activity
DA46_RS04295	COG0195	Participates in both transcription termination and antitermination
DA46_RS04320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DA46_RS04325	COG0564	pseudouridine synthase activity
DA46_RS04385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DA46_RS04400	COG2223	nitrite transmembrane transporter activity
DA46_RS04415	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DA46_RS04420	COG1053	succinate dehydrogenase
DA46_RS04455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA46_RS04480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA46_RS04515	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DA46_RS04525	COG1294	oxidase, subunit
DA46_RS04540	COG1090	epimerase
DA46_RS04565	COG3335	DDE superfamily endonuclease
DA46_RS04580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA46_RS04595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DA46_RS04625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA46_RS04705	COG4974	Belongs to the 'phage' integrase family
DA46_RS04740	COG3023	N-Acetylmuramoyl-L-alanine amidase
DA46_RS04750	COG2814	Major facilitator Superfamily
DA46_RS04755	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA46_RS04775	COG2890	protein-(glutamine-N5) methyltransferase activity
DA46_RS04790	COG3335	DDE superfamily endonuclease
DA46_RS04820	COG3335	DDE superfamily endonuclease
DA46_RS04830	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DA46_RS04855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA46_RS04870	COG1674	ftsk spoiiie
DA46_RS04880	COG0833	amino acid
DA46_RS04885	COG2945	thiolester hydrolase activity
DA46_RS04890	COG1494	fructose-1,6-bisphosphatase
DA46_RS04895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA46_RS04950	COG3335	DDE superfamily endonuclease
DA46_RS04960	COG0456	acetyltransferase
DA46_RS04965	COG2814	Major facilitator Superfamily
DA46_RS04970	COG2890	protein-(glutamine-N5) methyltransferase activity
DA46_RS04985	COG3335	DDE superfamily endonuclease
DA46_RS05005	COG1619	proteins homologs of microcin C7 resistance protein MccF
DA46_RS05025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA46_RS05030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA46_RS05055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA46_RS05055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA46_RS05065	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DA46_RS05070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DA46_RS05075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA46_RS05080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA46_RS05100	COG0552	protein localization to endoplasmic reticulum
DA46_RS05105	COG0210	DNA helicase
DA46_RS05120	COG4166	transmembrane transport
DA46_RS05125	COG0601	transmembrane transport
DA46_RS05130	COG0601	transmembrane transport
DA46_RS05140	COG0444	Belongs to the ABC transporter superfamily
DA46_RS05145	COG2814	Major facilitator Superfamily
DA46_RS05165	COG3335	DDE superfamily endonuclease
DA46_RS05185	COG0531	amino acid
DA46_RS05200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA46_RS05245	COG3335	DDE superfamily endonuclease
DA46_RS05255	COG3335	DDE superfamily endonuclease
DA46_RS05275	COG2814	Major facilitator Superfamily
DA46_RS05290	COG0488	(ABC) transporter
DA46_RS05305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DA46_RS05310	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DA46_RS05325	COG0772	Belongs to the SEDS family
DA46_RS05335	COG0463	Glycosyl transferase, family 2
DA46_RS05345	COG3335	DDE superfamily endonuclease
DA46_RS05350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DA46_RS05360	COG2920	part of a sulfur-relay system
DA46_RS05365	COG0625	glutathione transferase activity
DA46_RS05370	COG0616	signal peptide processing
DA46_RS05375	COG0470	DNA polymerase III
DA46_RS05385	COG0113	porphobilinogen synthase activity
DA46_RS05390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DA46_RS05395	COG0252	asparaginase activity
DA46_RS05415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA46_RS05425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DA46_RS05440	COG0439	Biotin carboxylase
DA46_RS05465	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DA46_RS05465	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DA46_RS05470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DA46_RS05480	COG0531	amino acid
DA46_RS05495	COG1162	GTPase activity
DA46_RS05510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DA46_RS05530	COG0492	ferredoxin-NADP+ reductase activity
DA46_RS05540	COG0546	phosphoglycolate phosphatase activity
DA46_RS05545	COG0583	DNA-binding transcription factor activity
DA46_RS05550	COG2814	Major facilitator Superfamily
DA46_RS05570	COG1446	asparaginase
DA46_RS05585	COG0628	permease
DA46_RS05595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DA46_RS05625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA46_RS05650	COG3335	DDE superfamily endonuclease
DA46_RS05660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DA46_RS05665	COG0204	Acyl-transferase
DA46_RS05665	COG0318	PFAM AMP-dependent synthetase and ligase
DA46_RS05675	COG3116	cell division
DA46_RS05730	COG1940	carbohydrate kinase activity
DA46_RS05750	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DA46_RS05755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DA46_RS05760	COG0814	amino acid
DA46_RS05770	COG0156	8-amino-7-oxononanoate synthase activity
DA46_RS05805	COG1131	(ABC) transporter
DA46_RS05815	COG0584	glycerophosphoryl diester phosphodiesterase
DA46_RS05820	COG2271	Major facilitator Superfamily
DA46_RS05840	COG3335	DDE superfamily endonuclease
DA46_RS05850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DA46_RS05865	COG0659	secondary active sulfate transmembrane transporter activity
DA46_RS05870	COG0251	oxidation-reduction process
DA46_RS05880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DA46_RS05885	COG4988	ABC transporter
DA46_RS05905	COG1940	carbohydrate kinase activity
DA46_RS05920	COG0247	lactate metabolic process
DA46_RS05920	COG0277	FAD linked oxidase domain protein
DA46_RS05930	COG0295	cytidine deaminase activity
DA46_RS05935	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DA46_RS05945	COG2860	membrane
DA46_RS05950	COG0742	ribosomal rna small subunit methyltransferase
DA46_RS05965	COG0795	lipopolysaccharide-transporting ATPase activity
DA46_RS05970	COG0795	lipopolysaccharide-transporting ATPase activity
DA46_RS05980	COG0517	IMP dehydrogenase activity
DA46_RS05980	COG0516	GMP reductase activity
DA46_RS06005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DA46_RS06025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DA46_RS06040	COG3335	DDE superfamily endonuclease
DA46_RS06045	COG0813	purine-nucleoside phosphorylase activity
DA46_RS06090	COG2814	Major facilitator Superfamily
DA46_RS06095	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DA46_RS06125	COG1611	Belongs to the LOG family
DA46_RS06165	COG0517	IMP dehydrogenase activity
DA46_RS06165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DA46_RS06170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DA46_RS06175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DA46_RS06180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA46_RS06190	COG1132	(ABC) transporter
DA46_RS06205	COG3475	LICD family
DA46_RS06210	COG1216	Glycosyl transferase, family 2
DA46_RS06210	COG1442	glycosyl transferase family 8
DA46_RS06215	COG1442	glycosyl transferase family 8
DA46_RS06215	COG1216	Glycosyl transferase, family 2
DA46_RS06220	COG0438	transferase activity, transferring glycosyl groups
DA46_RS06240	COG1446	asparaginase
DA46_RS06270	COG0477	Major facilitator Superfamily
DA46_RS06290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA46_RS06310	COG0509	glycine decarboxylation via glycine cleavage system
DA46_RS06320	COG3397	chitin binding
DA46_RS06355	COG3335	DDE superfamily endonuclease
DA46_RS06385	COG1085	galactose-1-phosphate uridylyltransferase
DA46_RS06390	COG2814	Major facilitator Superfamily
DA46_RS06395	COG2814	Major facilitator Superfamily
DA46_RS06400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA46_RS06405	COG0513	Belongs to the DEAD box helicase family
DA46_RS06415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DA46_RS06455	COG0386	Belongs to the glutathione peroxidase family
DA46_RS06490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DA46_RS06490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DA46_RS06495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DA46_RS06540	COG3335	DDE superfamily endonuclease
DA46_RS06575	COG1509	lysine 2,3-aminomutase activity
DA46_RS06580	COG1278	Cold shock
DA46_RS06605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA46_RS06610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DA46_RS06615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA46_RS06620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA46_RS06645	COG0084	hydrolase, TatD family'
DA46_RS06650	COG0751	glycine-tRNA ligase activity
DA46_RS06695	COG3104	oligopeptide transport
DA46_RS06715	COG1605	Chorismate mutase
DA46_RS06715	COG0077	Prephenate dehydratase
DA46_RS06725	COG1760	l-serine dehydratase
DA46_RS06730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA46_RS06735	COG0316	Belongs to the HesB IscA family
DA46_RS06740	COG2151	metal-sulfur cluster biosynthetic enzyme
DA46_RS06750	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA46_RS06805	COG3335	DDE superfamily endonuclease
DA46_RS06825	COG1288	antiporter activity
DA46_RS06830	COG1288	antiporter activity
DA46_RS06845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DA46_RS06850	COG0285	dihydrofolate synthase activity
DA46_RS06855	COG0802	atpase or kinase
DA46_RS06865	COG0728	peptidoglycan biosynthetic process
DA46_RS06870	COG2918	glutathione biosynthetic process
DA46_RS06900	COG3335	DDE superfamily endonuclease
DA46_RS06920	COG0300	oxidoreductase activity
DA46_RS06930	COG2081	HI0933 family
DA46_RS06940	COG3335	DDE superfamily endonuclease
DA46_RS06975	COG0189	ligase activity
DA46_RS06985	COG1472	Belongs to the glycosyl hydrolase 3 family
DA46_RS06990	COG1028	Short-chain dehydrogenase reductase Sdr
DA46_RS06995	COG1028	Short-chain dehydrogenase reductase Sdr
DA46_RS07015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DA46_RS07015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DA46_RS07030	COG0156	8-amino-7-oxononanoate synthase activity
DA46_RS07040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA46_RS07060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DA46_RS07060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DA46_RS07065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DA46_RS07075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA46_RS07075	COG0512	Glutamine amidotransferase of anthranilate synthase
DA46_RS07080	COG0512	Glutamine amidotransferase of anthranilate synthase
DA46_RS07080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DA46_RS07090	COG2271	Major facilitator Superfamily
DA46_RS07095	COG0667	Aldo Keto reductase
DA46_RS07120	COG0302	gtp cyclohydrolase
DA46_RS07125	COG0513	Belongs to the DEAD box helicase family
DA46_RS07130	COG3104	oligopeptide transport
DA46_RS07145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA46_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
DA46_RS07165	COG0708	Exodeoxyribonuclease III
DA46_RS07185	COG3335	DDE superfamily endonuclease
DA46_RS07190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DA46_RS07195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DA46_RS07225	COG0531	amino acid
DA46_RS07230	COG0569	domain protein
DA46_RS07240	COG0719	Fe-S assembly protein
DA46_RS07245	COG0396	ATPase activity
DA46_RS07250	COG0719	Fe-S assembly protein
DA46_RS07285	COG0833	amino acid
DA46_RS07350	COG0489	protein tyrosine kinase activity
DA46_RS07360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA46_RS07365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA46_RS07380	COG0523	cobalamin synthesis protein
DA46_RS07385	COG0735	belongs to the Fur family
DA46_RS07390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA46_RS07390	COG0072	phenylalanine-tRNA ligase activity
DA46_RS07400	COG0697	spore germination
DA46_RS07405	COG3335	DDE superfamily endonuclease
DA46_RS07420	COG0583	DNA-binding transcription factor activity
DA46_RS07440	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DA46_RS07455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DA46_RS07515	COG0583	DNA-binding transcription factor activity
DA46_RS07530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DA46_RS07650	COG0738	Major facilitator superfamily
DA46_RS07655	COG3335	DDE superfamily endonuclease
DA46_RS07670	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DA46_RS07675	COG0191	fructose-bisphosphate aldolase activity
DA46_RS07680	COG0469	pyruvate kinase activity
DA46_RS07720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DA46_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
DA46_RS07730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA46_RS07735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA46_RS07745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA46_RS07745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DA46_RS07755	COG2855	membrane
DA46_RS07760	COG0483	inositol monophosphate 1-phosphatase activity
DA46_RS07785	COG3335	DDE superfamily endonuclease
DA46_RS07795	COG1396	sequence-specific DNA binding
DA46_RS07800	COG3550	peptidyl-serine autophosphorylation
DA46_RS07835	COG2974	May be involved in recombination
DA46_RS07845	COG2996	Protein conserved in bacteria
DA46_RS07850	COG0210	DNA helicase
DA46_RS07855	COG0354	folic acid binding
DA46_RS07885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DA46_RS07890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DA46_RS07955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA46_RS07960	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DA46_RS07970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA46_RS08015	COG3655	Transcriptional regulator
DA46_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
DA46_RS08075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DA46_RS08080	COG0179	Fumarylacetoacetate (FAA) hydrolase
DA46_RS08085	COG1137	ATPase activity
DA46_RS08100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DA46_RS08105	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DA46_RS08110	COG1686	Belongs to the peptidase S11 family
DA46_RS08115	COG2921	Belongs to the UPF0250 family
DA46_RS08145	COG0358	DNA primase activity
DA46_RS08150	COG1610	YqeY-like protein
DA46_RS08160	COG2027	D-alanyl-D-alanine carboxypeptidase
DA46_RS08185	COG0142	geranyltranstransferase activity
DA46_RS08245	COG1187	pseudouridine synthase activity
DA46_RS08295	COG3335	DDE superfamily endonuclease
DA46_RS08325	COG0583	DNA-binding transcription factor activity
DA46_RS08335	COG1937	Protein conserved in bacteria
DA46_RS08345	COG1012	belongs to the aldehyde dehydrogenase family
DA46_RS08360	COG1876	peptidase activity
DA46_RS08400	COG0450	alkyl hydroperoxide reductase
DA46_RS08415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DA46_RS08420	COG3335	DDE superfamily endonuclease
DA46_RS08430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DA46_RS08460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DA46_RS08470	COG0488	(ABC) transporter
DA46_RS08495	COG2852	Protein conserved in bacteria
DA46_RS08500	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DA46_RS08505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA46_RS08510	COG2264	protein methyltransferase activity
DA46_RS08515	COG1979	alcohol dehydrogenase
DA46_RS08525	COG0277	FAD linked oxidase domain protein
DA46_RS08530	COG3961	Belongs to the TPP enzyme family
DA46_RS08545	COG3335	DDE superfamily endonuclease
DA46_RS08555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DA46_RS08560	COG0095	Lipoate-protein ligase
DA46_RS08570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DA46_RS08580	COG3104	oligopeptide transport
DA46_RS08595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DA46_RS08615	COG0012	GTP binding
DA46_RS08630	COG4536	flavin adenine dinucleotide binding
DA46_RS08640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DA46_RS08700	COG0076	glutamate decarboxylase activity
DA46_RS08735	COG2271	Major facilitator Superfamily
DA46_RS08750	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DA46_RS08760	COG1528	Iron-storage protein
DA46_RS08770	COG2999	glutathione oxidoreductase activity
DA46_RS08775	COG2878	Part of a membrane complex involved in electron transport
DA46_RS08780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DA46_RS08795	COG0670	Belongs to the BI1 family
DA46_RS08800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DA46_RS08805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DA46_RS08825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA46_RS08835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DA46_RS08850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA46_RS08855	COG0330	HflC and HflK could
DA46_RS08860	COG0330	HflC and HflK could
DA46_RS08870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DA46_RS08895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DA46_RS08900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DA46_RS08930	COG4122	O-methyltransferase activity
DA46_RS08940	COG1702	phosphate starvation-inducible protein PhoH
DA46_RS08950	COG4535	Mg2 and Co2 transporter CorC
DA46_RS08955	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DA46_RS08985	COG1496	oxidoreductase activity
DA46_RS09040	COG2814	Major facilitator Superfamily
DA46_RS09045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DA46_RS09050	COG1823	symporter activity
DA46_RS09070	COG1773	rubredoxin
DA46_RS09075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DA46_RS09085	COG0288	reversible hydration of carbon dioxide
DA46_RS09090	COG0252	asparaginase activity
DA46_RS09105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DA46_RS09110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA46_RS09120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA46_RS09125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA46_RS09130	COG1862	Preprotein translocase
DA46_RS09140	COG1335	isochorismatase
DA46_RS09150	COG0583	DNA-binding transcription factor activity
DA46_RS09185	COG1464	Belongs to the NlpA lipoprotein family
DA46_RS09190	COG0814	amino acid
DA46_RS09200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA46_RS09210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DA46_RS09210	COG1181	Belongs to the D-alanine--D-alanine ligase family
DA46_RS09215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DA46_RS09215	COG0189	ligase activity
DA46_RS09230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA46_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
DA46_RS09305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DA46_RS09310	COG2814	Major facilitator Superfamily
DA46_RS09315	COG0531	amino acid
DA46_RS09325	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DA46_RS09395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DA46_RS09400	COG0436	Aminotransferase
DA46_RS09410	COG1214	PFAM Peptidase M22, glycoprotease
DA46_RS09415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DA46_RS09420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DA46_RS09440	COG3335	DDE superfamily endonuclease
DA46_RS09480	COG1217	gtp-binding protein TYPA
DA46_RS09490	COG0405	Gamma-glutamyltransferase
DA46_RS09500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA46_RS09500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DA46_RS09505	COG2914	Belongs to the UPF0125 (RnfH) family
DA46_RS09510	COG2867	negative regulation of translational initiation
DA46_RS09545	COG1473	amidohydrolase
DA46_RS09570	COG0477	Major facilitator Superfamily
DA46_RS09585	COG0556	nucleotide-excision repair
DA46_RS09590	COG2925	Exonuclease
DA46_RS09595	COG4221	oxidoreductase activity
DA46_RS09640	COG3590	peptidase
DA46_RS09645	COG3335	DDE superfamily endonuclease
DA46_RS09660	COG0346	lactoylglutathione lyase activity
DA46_RS09665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DA46_RS09670	COG0561	phosphatase activity
DA46_RS09685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA46_RS09690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA46_RS09695	COG3079	Belongs to the UPF0149 family
DA46_RS09710	COG0586	Pfam SNARE associated Golgi protein
DA46_RS09715	COG0586	Pfam SNARE associated Golgi protein
DA46_RS09735	COG1530	ribonuclease E activity
DA46_RS09750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA46_RS09795	COG3028	Belongs to the UPF0307 family
DA46_RS09815	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA46_RS09820	COG0564	pseudouridine synthase activity
DA46_RS09825	COG2992	FlgJ-related protein
DA46_RS09830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DA46_RS09835	COG1127	ABC transporter
DA46_RS09855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DA46_RS09865	COG0318	PFAM AMP-dependent synthetase and ligase
DA46_RS09875	COG0477	Major facilitator Superfamily
DA46_RS09890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DA46_RS09900	COG0655	NAD(P)H dehydrogenase (quinone) activity
DA46_RS09915	COG3842	ATPase activity
DA46_RS09920	COG1176	ABC-type spermidine putrescine transport system, permease component I
DA46_RS09925	COG1177	transmembrane transport
DA46_RS09935	COG3335	DDE superfamily endonuclease