locus-tag	class	description
FTH_RS00015	COG0477	Major facilitator Superfamily
FTH_RS00030	COG3961	Belongs to the TPP enzyme family
FTH_RS00050	COG0425	Belongs to the sulfur carrier protein TusA family
FTH_RS00050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTH_RS00065	COG2137	regulation of response to DNA damage stimulus
FTH_RS00070	COG0629	single-stranded DNA binding
FTH_RS00080	COG0280	phosphate acetyltransferase
FTH_RS00080	COG0857	belongs to the CobB CobQ family
FTH_RS00090	COG3335	DDE superfamily endonuclease
FTH_RS00125	COG3335	DDE superfamily endonuclease
FTH_RS00130	COG0814	amino acid
FTH_RS00145	COG0540	Belongs to the ATCase OTCase family
FTH_RS00150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FTH_RS00155	COG0505	Belongs to the CarA family
FTH_RS00200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FTH_RS00210	COG0583	DNA-binding transcription factor activity
FTH_RS00235	COG0284	orotidine-5'-phosphate decarboxylase activity
FTH_RS00245	COG0287	Prephenate dehydrogenase
FTH_RS00245	COG1605	Chorismate mutase
FTH_RS00250	COG0287	Prephenate dehydrogenase
FTH_RS00250	COG1605	Chorismate mutase
FTH_RS00265	COG1621	beta-fructofuranosidase activity
FTH_RS00270	COG3335	DDE superfamily endonuclease
FTH_RS00290	COG0778	Nitroreductase
FTH_RS00300	COG0814	amino acid
FTH_RS00325	COG2814	Major facilitator Superfamily
FTH_RS00335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FTH_RS00340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTH_RS00365	COG0242	peptide deformylase activity
FTH_RS00375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FTH_RS00375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FTH_RS00385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FTH_RS00385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FTH_RS00395	COG3335	DDE superfamily endonuclease
FTH_RS00430	COG0204	Acyl-transferase
FTH_RS00440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FTH_RS00465	COG0542	response to heat
FTH_RS00490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FTH_RS00515	COG3201	nicotinamide mononucleotide transporter
FTH_RS00525	COG3335	DDE superfamily endonuclease
FTH_RS00530	COG0738	Major facilitator superfamily
FTH_RS00660	COG3335	DDE superfamily endonuclease
FTH_RS00675	COG0574	Belongs to the PEP-utilizing enzyme family
FTH_RS00675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FTH_RS00680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FTH_RS00690	COG3335	DDE superfamily endonuclease
FTH_RS00715	COG0557	exoribonuclease II activity
FTH_RS00760	COG1116	anion transmembrane transporter activity
FTH_RS00775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FTH_RS00805	COG3335	DDE superfamily endonuclease
FTH_RS00840	COG1984	allophanate hydrolase subunit 2
FTH_RS00865	COG3335	DDE superfamily endonuclease
FTH_RS00880	COG0589	response to stress
FTH_RS00905	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FTH_RS00915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FTH_RS00930	COG0594	ribonuclease P activity
FTH_RS00945	COG1560	Kdo2-lipid A biosynthetic process
FTH_RS00950	COG1560	Kdo2-lipid A biosynthetic process
FTH_RS00980	COG3335	DDE superfamily endonuclease
FTH_RS00985	COG2814	Major facilitator Superfamily
FTH_RS00990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FTH_RS01000	COG1294	oxidase, subunit
FTH_RS01005	COG1271	oxidase subunit
FTH_RS01010	COG2814	Major facilitator Superfamily
FTH_RS01015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FTH_RS01020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FTH_RS01030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FTH_RS01050	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FTH_RS01060	COG0714	Associated with various cellular activities
FTH_RS01080	COG2304	oxidoreductase activity
FTH_RS01095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FTH_RS01110	COG0525	valine-tRNA ligase activity
FTH_RS01130	COG1304	FMN binding
FTH_RS01145	COG0114	fumarate hydratase activity
FTH_RS01165	COG0531	amino acid
FTH_RS01180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FTH_RS01205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FTH_RS01210	COG0575	Belongs to the CDS family
FTH_RS01220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FTH_RS01345	COG0201	protein transport
FTH_RS01395	COG3335	DDE superfamily endonuclease
FTH_RS01405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FTH_RS01410	COG3335	DDE superfamily endonuclease
FTH_RS01420	COG3335	DDE superfamily endonuclease
FTH_RS01445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FTH_RS01465	COG0531	amino acid
FTH_RS01475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FTH_RS01480	COG0398	Pfam SNARE associated Golgi protein
FTH_RS01485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FTH_RS01490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FTH_RS01500	COG0531	amino acid
FTH_RS01515	COG0814	amino acid
FTH_RS01525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FTH_RS01550	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FTH_RS01555	COG0814	amino acid
FTH_RS01600	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FTH_RS01635	COG0180	Tryptophanyl-tRNA synthetase
FTH_RS01650	COG0237	dephospho-CoA kinase activity
FTH_RS01665	COG0508	dehydrogenase complex catalyzes the overall conversion of
FTH_RS01670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FTH_RS01680	COG3335	DDE superfamily endonuclease
FTH_RS01685	COG1051	belongs to the nudix hydrolase family
FTH_RS01740	COG4401	Chorismate mutase type I
FTH_RS01745	COG1183	phosphatidylcholine synthase activity
FTH_RS01755	COG0811	peptide transport
FTH_RS01790	COG0456	acetyltransferase
FTH_RS01800	COG3335	DDE superfamily endonuclease
FTH_RS01810	COG0415	Belongs to the DNA photolyase family
FTH_RS01815	COG0415	Belongs to the DNA photolyase family
FTH_RS01820	COG3046	protein related to deoxyribodipyrimidine photolyase
FTH_RS01830	COG0385	Bile acid
FTH_RS01860	COG2363	Small membrane protein
FTH_RS01865	COG3335	DDE superfamily endonuclease
FTH_RS01915	COG1704	LemA family
FTH_RS01995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTH_RS01995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTH_RS02010	COG0833	amino acid
FTH_RS02025	COG0436	Aminotransferase
FTH_RS02035	COG0497	DNA recombination
FTH_RS02055	COG4969	Belongs to the N-Me-Phe pilin family
FTH_RS02060	COG0671	phosphoesterase, PA-phosphatase related
FTH_RS02070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FTH_RS02080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FTH_RS02100	COG0009	L-threonylcarbamoyladenylate synthase
FTH_RS02105	COG2917	probably involved in intracellular septation
FTH_RS02115	COG0837	glucose binding
FTH_RS02130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FTH_RS02135	COG0537	adenosine 5'-monophosphoramidase activity
FTH_RS02145	COG1040	competence protein
FTH_RS02150	COG2226	methyltransferase
FTH_RS02160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FTH_RS02165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FTH_RS02195	COG0339	signal peptide processing
FTH_RS02235	COG1192	Involved in chromosome partitioning
FTH_RS02240	COG1475	DNA binding
FTH_RS02245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FTH_RS02245	COG0519	Catalyzes the synthesis of GMP from XMP
FTH_RS02280	COG0196	riboflavin kinase activity
FTH_RS02285	COG0281	malic enzyme
FTH_RS02305	COG3335	DDE superfamily endonuclease
FTH_RS02320	COG1739	Uncharacterized protein family UPF0029
FTH_RS02325	COG2271	Major facilitator Superfamily
FTH_RS02385	COG1994	Peptidase M50
FTH_RS02405	COG1056	cytidyltransferase-related domain
FTH_RS02405	COG1051	belongs to the nudix hydrolase family
FTH_RS02415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FTH_RS02455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FTH_RS02460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FTH_RS02475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FTH_RS02500	COG0587	DNA-directed DNA polymerase activity
FTH_RS02505	COG0242	peptide deformylase activity
FTH_RS02525	COG1982	Orn Lys Arg decarboxylase major
FTH_RS02535	COG0509	glycine decarboxylation via glycine cleavage system
FTH_RS02555	COG1523	belongs to the glycosyl hydrolase 13 family
FTH_RS02565	COG0033	Phosphoglucomutase
FTH_RS02580	COG0058	SHG alpha-glucan phosphorylase activity
FTH_RS02585	COG1640	4-alpha-glucanotransferase
FTH_RS02595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTH_RS02605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FTH_RS02625	COG0083	homoserine kinase activity
FTH_RS02630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FTH_RS02635	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FTH_RS02660	COG3335	DDE superfamily endonuclease
FTH_RS02680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FTH_RS02685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FTH_RS02690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FTH_RS02695	COG3335	DDE superfamily endonuclease
FTH_RS02725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FTH_RS02730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FTH_RS02735	COG1127	ABC transporter
FTH_RS02750	COG0850	regulation of cytokinetic process
FTH_RS02770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FTH_RS02780	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FTH_RS02830	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTH_RS02850	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FTH_RS02870	COG1472	Belongs to the glycosyl hydrolase 3 family
FTH_RS02885	COG1183	phosphatidylcholine synthase activity
FTH_RS02890	COG0142	geranyltranstransferase activity
FTH_RS02895	COG1519	Transferase
FTH_RS02900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FTH_RS02905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FTH_RS02910	COG2828	Protein conserved in bacteria
FTH_RS02915	COG2828	Protein conserved in bacteria
FTH_RS02925	COG0681	Belongs to the peptidase S26 family
FTH_RS02940	COG0557	exoribonuclease II activity
FTH_RS02965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FTH_RS02985	COG5002	protein histidine kinase activity
FTH_RS03075	COG0183	Belongs to the thiolase family
FTH_RS03080	COG1024	Enoyl-CoA hydratase
FTH_RS03080	COG1250	3-hydroxyacyl-CoA dehydrogenase
FTH_RS03085	COG1960	acyl-CoA dehydrogenase activity
FTH_RS03090	COG0318	PFAM AMP-dependent synthetase and ligase
FTH_RS03095	COG1393	Belongs to the ArsC family
FTH_RS03110	COG1643	Atp-dependent helicase
FTH_RS03120	COG1086	Polysaccharide biosynthesis protein
FTH_RS03125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FTH_RS03145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FTH_RS03160	COG0367	asparagine synthase
FTH_RS03180	COG1215	transferase activity, transferring glycosyl groups
FTH_RS03185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FTH_RS03200	COG3335	DDE superfamily endonuclease
FTH_RS03205	COG0662	Cupin 2, conserved barrel domain protein
FTH_RS03205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FTH_RS03220	COG3118	belongs to the thioredoxin family
FTH_RS03225	COG0248	Ppx GppA phosphatase
FTH_RS03240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FTH_RS03265	COG0084	hydrolase, TatD family'
FTH_RS03275	COG0730	response to heat
FTH_RS03285	COG1131	(ABC) transporter
FTH_RS03290	COG0842	Transport permease protein
FTH_RS03295	COG0463	Glycosyl transferase, family 2
FTH_RS03305	COG1280	lysine exporter protein (LysE YggA)
FTH_RS03325	COG3335	DDE superfamily endonuclease
FTH_RS03340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTH_RS03365	COG2983	Belongs to the UPF0260 family
FTH_RS03435	COG2166	iron-sulfur cluster assembly
FTH_RS03500	COG0697	spore germination
FTH_RS03505	COG0069	glutamate synthase activity
FTH_RS03510	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FTH_RS03525	COG1074	ATP-dependent DNA helicase activity
FTH_RS03530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FTH_RS03575	COG1177	transmembrane transport
FTH_RS03580	COG1176	ABC-type spermidine putrescine transport system, permease component I
FTH_RS03585	COG3842	ATPase activity
FTH_RS03590	COG3335	DDE superfamily endonuclease
FTH_RS03605	COG0655	NAD(P)H dehydrogenase (quinone) activity
FTH_RS03615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FTH_RS03630	COG0477	Major facilitator Superfamily
FTH_RS03640	COG0318	PFAM AMP-dependent synthetase and ligase
FTH_RS03650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FTH_RS03670	COG1127	ABC transporter
FTH_RS03675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FTH_RS03680	COG2992	FlgJ-related protein
FTH_RS03685	COG0564	pseudouridine synthase activity
FTH_RS03690	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTH_RS03710	COG3028	Belongs to the UPF0307 family
FTH_RS03755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FTH_RS03770	COG1530	ribonuclease E activity
FTH_RS03790	COG0586	Pfam SNARE associated Golgi protein
FTH_RS03795	COG0586	Pfam SNARE associated Golgi protein
FTH_RS03810	COG3079	Belongs to the UPF0149 family
FTH_RS03815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FTH_RS03820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FTH_RS03835	COG0561	phosphatase activity
FTH_RS03840	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FTH_RS03845	COG0346	lactoylglutathione lyase activity
FTH_RS03860	COG3335	DDE superfamily endonuclease
FTH_RS03865	COG3590	peptidase
FTH_RS03910	COG4221	oxidoreductase activity
FTH_RS03915	COG2925	Exonuclease
FTH_RS03920	COG0556	nucleotide-excision repair
FTH_RS03935	COG0477	Major facilitator Superfamily
FTH_RS03960	COG1473	amidohydrolase
FTH_RS03995	COG2867	negative regulation of translational initiation
FTH_RS04000	COG2914	Belongs to the UPF0125 (RnfH) family
FTH_RS04005	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FTH_RS04005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FTH_RS04015	COG0405	Gamma-glutamyltransferase
FTH_RS04025	COG1217	gtp-binding protein TYPA
FTH_RS04085	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FTH_RS04090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FTH_RS04095	COG1214	PFAM Peptidase M22, glycoprotease
FTH_RS04105	COG0436	Aminotransferase
FTH_RS04110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FTH_RS04180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FTH_RS04190	COG0531	amino acid
FTH_RS04195	COG2814	Major facilitator Superfamily
FTH_RS04200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FTH_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
FTH_RS04275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FTH_RS04290	COG0189	ligase activity
FTH_RS04290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTH_RS04295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FTH_RS04295	COG1181	Belongs to the D-alanine--D-alanine ligase family
FTH_RS04305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FTH_RS04315	COG0814	amino acid
FTH_RS04320	COG1464	Belongs to the NlpA lipoprotein family
FTH_RS04355	COG0583	DNA-binding transcription factor activity
FTH_RS04365	COG1335	isochorismatase
FTH_RS04375	COG1862	Preprotein translocase
FTH_RS04380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FTH_RS04385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FTH_RS04395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FTH_RS04400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FTH_RS04415	COG0252	asparaginase activity
FTH_RS04420	COG0288	reversible hydration of carbon dioxide
FTH_RS04430	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FTH_RS04435	COG1773	rubredoxin
FTH_RS04455	COG1823	symporter activity
FTH_RS04460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FTH_RS04465	COG2814	Major facilitator Superfamily
FTH_RS04520	COG1496	oxidoreductase activity
FTH_RS04550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FTH_RS04555	COG4535	Mg2 and Co2 transporter CorC
FTH_RS04565	COG1702	phosphate starvation-inducible protein PhoH
FTH_RS04575	COG4122	O-methyltransferase activity
FTH_RS04605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FTH_RS04610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FTH_RS04635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FTH_RS04645	COG0330	HflC and HflK could
FTH_RS04650	COG0330	HflC and HflK could
FTH_RS04655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FTH_RS04670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FTH_RS04680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FTH_RS04700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FTH_RS04705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FTH_RS04710	COG0670	Belongs to the BI1 family
FTH_RS04725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FTH_RS04730	COG2878	Part of a membrane complex involved in electron transport
FTH_RS04735	COG2999	glutathione oxidoreductase activity
FTH_RS04745	COG1528	Iron-storage protein
FTH_RS04755	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FTH_RS04770	COG2271	Major facilitator Superfamily
FTH_RS04805	COG0076	glutamate decarboxylase activity
FTH_RS04865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FTH_RS04875	COG4536	flavin adenine dinucleotide binding
FTH_RS04890	COG0012	GTP binding
FTH_RS04910	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FTH_RS04925	COG3104	oligopeptide transport
FTH_RS04935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FTH_RS04945	COG0095	Lipoate-protein ligase
FTH_RS04950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FTH_RS04960	COG3335	DDE superfamily endonuclease
FTH_RS04975	COG3961	Belongs to the TPP enzyme family
FTH_RS04980	COG0277	FAD linked oxidase domain protein
FTH_RS04990	COG1979	alcohol dehydrogenase
FTH_RS04995	COG2264	protein methyltransferase activity
FTH_RS05000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FTH_RS05005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FTH_RS05010	COG2852	Protein conserved in bacteria
FTH_RS05035	COG0488	(ABC) transporter
FTH_RS05045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FTH_RS05075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FTH_RS05085	COG3335	DDE superfamily endonuclease
FTH_RS05090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FTH_RS05105	COG0450	alkyl hydroperoxide reductase
FTH_RS05145	COG1876	peptidase activity
FTH_RS05160	COG1012	belongs to the aldehyde dehydrogenase family
FTH_RS05170	COG1937	Protein conserved in bacteria
FTH_RS05180	COG0583	DNA-binding transcription factor activity
FTH_RS05215	COG3335	DDE superfamily endonuclease
FTH_RS05265	COG1187	pseudouridine synthase activity
FTH_RS05325	COG0142	geranyltranstransferase activity
FTH_RS05350	COG2027	D-alanyl-D-alanine carboxypeptidase
FTH_RS05360	COG1610	YqeY-like protein
FTH_RS05365	COG0358	DNA primase activity
FTH_RS05395	COG2921	Belongs to the UPF0250 family
FTH_RS05400	COG1686	Belongs to the peptidase S11 family
FTH_RS05405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FTH_RS05410	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FTH_RS05425	COG1137	ATPase activity
FTH_RS05430	COG0179	Fumarylacetoacetate (FAA) hydrolase
FTH_RS05435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FTH_RS05475	COG1028	Short-chain dehydrogenase reductase Sdr
FTH_RS05495	COG3655	Transcriptional regulator
FTH_RS05540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FTH_RS05550	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FTH_RS05555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTH_RS05620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FTH_RS05625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FTH_RS05655	COG0354	folic acid binding
FTH_RS05660	COG0210	DNA helicase
FTH_RS05665	COG2996	Protein conserved in bacteria
FTH_RS05675	COG2974	May be involved in recombination
FTH_RS05710	COG3550	peptidyl-serine autophosphorylation
FTH_RS05715	COG1396	sequence-specific DNA binding
FTH_RS05725	COG3335	DDE superfamily endonuclease
FTH_RS05750	COG0483	inositol monophosphate 1-phosphatase activity
FTH_RS05755	COG2855	membrane
FTH_RS05765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FTH_RS05765	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FTH_RS05775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FTH_RS05780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FTH_RS05785	COG1028	Short-chain dehydrogenase reductase Sdr
FTH_RS05790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FTH_RS05830	COG0469	pyruvate kinase activity
FTH_RS05835	COG0191	fructose-bisphosphate aldolase activity
FTH_RS05840	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FTH_RS05855	COG0738	Major facilitator superfamily
FTH_RS05975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FTH_RS05990	COG0583	DNA-binding transcription factor activity
FTH_RS06050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FTH_RS06065	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FTH_RS06085	COG0583	DNA-binding transcription factor activity
FTH_RS06100	COG3335	DDE superfamily endonuclease
FTH_RS06105	COG0697	spore germination
FTH_RS06115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FTH_RS06115	COG0072	phenylalanine-tRNA ligase activity
FTH_RS06120	COG0735	belongs to the Fur family
FTH_RS06125	COG0523	cobalamin synthesis protein
FTH_RS06140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FTH_RS06145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FTH_RS06155	COG0489	protein tyrosine kinase activity
FTH_RS06220	COG0833	amino acid
FTH_RS06255	COG0719	Fe-S assembly protein
FTH_RS06260	COG0396	ATPase activity
FTH_RS06265	COG0719	Fe-S assembly protein
FTH_RS06275	COG0569	domain protein
FTH_RS06280	COG0531	amino acid
FTH_RS06310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FTH_RS06315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FTH_RS06320	COG3335	DDE superfamily endonuclease
FTH_RS06340	COG0708	Exodeoxyribonuclease III
FTH_RS06345	COG1028	Short-chain dehydrogenase reductase Sdr
FTH_RS06360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FTH_RS06375	COG3104	oligopeptide transport
FTH_RS06380	COG0513	Belongs to the DEAD box helicase family
FTH_RS06385	COG0302	gtp cyclohydrolase
FTH_RS06410	COG0667	Aldo Keto reductase
FTH_RS06415	COG2271	Major facilitator Superfamily
FTH_RS06425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FTH_RS06425	COG0512	Glutamine amidotransferase of anthranilate synthase
FTH_RS06430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FTH_RS06430	COG0512	Glutamine amidotransferase of anthranilate synthase
FTH_RS06440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FTH_RS06445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FTH_RS06445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FTH_RS06465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FTH_RS06475	COG0156	8-amino-7-oxononanoate synthase activity
FTH_RS06490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FTH_RS06490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FTH_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
FTH_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
FTH_RS06520	COG1472	Belongs to the glycosyl hydrolase 3 family
FTH_RS06530	COG0189	ligase activity
FTH_RS06565	COG3335	DDE superfamily endonuclease
FTH_RS06575	COG2081	HI0933 family
FTH_RS06585	COG0300	oxidoreductase activity
FTH_RS06605	COG3335	DDE superfamily endonuclease
FTH_RS06635	COG2918	glutathione biosynthetic process
FTH_RS06640	COG0728	peptidoglycan biosynthetic process
FTH_RS06650	COG0802	atpase or kinase
FTH_RS06655	COG0285	dihydrofolate synthase activity
FTH_RS06660	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FTH_RS06675	COG1288	antiporter activity
FTH_RS06680	COG1288	antiporter activity
FTH_RS06700	COG3335	DDE superfamily endonuclease
FTH_RS06755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FTH_RS06765	COG2151	metal-sulfur cluster biosynthetic enzyme
FTH_RS06770	COG0316	Belongs to the HesB IscA family
FTH_RS06775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FTH_RS06780	COG1760	l-serine dehydratase
FTH_RS06790	COG1605	Chorismate mutase
FTH_RS06790	COG0077	Prephenate dehydratase
FTH_RS06810	COG3104	oligopeptide transport
FTH_RS06855	COG0751	glycine-tRNA ligase activity
FTH_RS06860	COG0084	hydrolase, TatD family'
FTH_RS06885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FTH_RS06890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FTH_RS06895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FTH_RS06900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FTH_RS06930	COG1278	Cold shock
FTH_RS06935	COG1509	lysine 2,3-aminomutase activity
FTH_RS06975	COG3335	DDE superfamily endonuclease
FTH_RS07020	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FTH_RS07025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FTH_RS07025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FTH_RS07060	COG0386	Belongs to the glutathione peroxidase family
FTH_RS07100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FTH_RS07110	COG0513	Belongs to the DEAD box helicase family
FTH_RS07115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FTH_RS07120	COG2814	Major facilitator Superfamily
FTH_RS07125	COG2814	Major facilitator Superfamily
FTH_RS07130	COG1085	galactose-1-phosphate uridylyltransferase
FTH_RS07160	COG3335	DDE superfamily endonuclease
FTH_RS07200	COG3397	chitin binding
FTH_RS07210	COG0509	glycine decarboxylation via glycine cleavage system
FTH_RS07230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FTH_RS07250	COG0477	Major facilitator Superfamily
FTH_RS07280	COG1446	asparaginase
FTH_RS07300	COG0438	transferase activity, transferring glycosyl groups
FTH_RS07305	COG1442	glycosyl transferase family 8
FTH_RS07305	COG1216	Glycosyl transferase, family 2
FTH_RS07310	COG1216	Glycosyl transferase, family 2
FTH_RS07310	COG1442	glycosyl transferase family 8
FTH_RS07315	COG3475	LICD family
FTH_RS07330	COG1132	(ABC) transporter
FTH_RS07340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FTH_RS07345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FTH_RS07350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FTH_RS07355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FTH_RS07355	COG0517	IMP dehydrogenase activity
FTH_RS07395	COG1611	Belongs to the LOG family
FTH_RS07425	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FTH_RS07430	COG2814	Major facilitator Superfamily
FTH_RS07475	COG0813	purine-nucleoside phosphorylase activity
FTH_RS07480	COG3335	DDE superfamily endonuclease
FTH_RS07495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FTH_RS07515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FTH_RS07540	COG0516	GMP reductase activity
FTH_RS07540	COG0517	IMP dehydrogenase activity
FTH_RS07550	COG0795	lipopolysaccharide-transporting ATPase activity
FTH_RS07555	COG0795	lipopolysaccharide-transporting ATPase activity
FTH_RS07570	COG0742	ribosomal rna small subunit methyltransferase
FTH_RS07575	COG2860	membrane
FTH_RS07585	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FTH_RS07590	COG0295	cytidine deaminase activity
FTH_RS07600	COG0277	FAD linked oxidase domain protein
FTH_RS07600	COG0247	lactate metabolic process
FTH_RS07615	COG1940	carbohydrate kinase activity
FTH_RS07635	COG4988	ABC transporter
FTH_RS07640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FTH_RS07650	COG0251	oxidation-reduction process
FTH_RS07655	COG0659	secondary active sulfate transmembrane transporter activity
FTH_RS07670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FTH_RS07680	COG3335	DDE superfamily endonuclease
FTH_RS07700	COG2271	Major facilitator Superfamily
FTH_RS07705	COG0584	glycerophosphoryl diester phosphodiesterase
FTH_RS07715	COG1131	(ABC) transporter
FTH_RS07750	COG0156	8-amino-7-oxononanoate synthase activity
FTH_RS07765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FTH_RS07770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FTH_RS07790	COG1940	carbohydrate kinase activity
FTH_RS07845	COG3116	cell division
FTH_RS07855	COG0204	Acyl-transferase
FTH_RS07855	COG0318	PFAM AMP-dependent synthetase and ligase
FTH_RS07860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FTH_RS07870	COG3335	DDE superfamily endonuclease
FTH_RS07895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FTH_RS07925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FTH_RS07935	COG0628	permease
FTH_RS07950	COG1446	asparaginase
FTH_RS07970	COG2814	Major facilitator Superfamily
FTH_RS07975	COG0583	DNA-binding transcription factor activity
FTH_RS07980	COG0546	phosphoglycolate phosphatase activity
FTH_RS07990	COG0492	ferredoxin-NADP+ reductase activity
FTH_RS08010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FTH_RS08025	COG1162	GTPase activity
FTH_RS08040	COG0531	amino acid
FTH_RS08050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FTH_RS08055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FTH_RS08055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FTH_RS08080	COG0439	Biotin carboxylase
FTH_RS08095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FTH_RS08105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FTH_RS08125	COG0252	asparaginase activity
FTH_RS08130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FTH_RS08135	COG0113	porphobilinogen synthase activity
FTH_RS08145	COG0470	DNA polymerase III
FTH_RS08150	COG0616	signal peptide processing
FTH_RS08155	COG0625	glutathione transferase activity
FTH_RS08160	COG2920	part of a sulfur-relay system
FTH_RS08170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FTH_RS08175	COG3335	DDE superfamily endonuclease
FTH_RS08185	COG0463	Glycosyl transferase, family 2
FTH_RS08195	COG0772	Belongs to the SEDS family
FTH_RS08210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FTH_RS08215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FTH_RS08230	COG0488	(ABC) transporter
FTH_RS08245	COG2814	Major facilitator Superfamily
FTH_RS08265	COG3335	DDE superfamily endonuclease
FTH_RS08275	COG3335	DDE superfamily endonuclease
FTH_RS08320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FTH_RS08355	COG3335	DDE superfamily endonuclease
FTH_RS08375	COG2814	Major facilitator Superfamily
FTH_RS08380	COG0444	Belongs to the ABC transporter superfamily
FTH_RS08395	COG4166	transmembrane transport
FTH_RS08410	COG0210	DNA helicase
FTH_RS08415	COG0552	protein localization to endoplasmic reticulum
FTH_RS08435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FTH_RS08440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FTH_RS08445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FTH_RS08450	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FTH_RS08460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FTH_RS08460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FTH_RS08485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FTH_RS08490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FTH_RS08510	COG1619	proteins homologs of microcin C7 resistance protein MccF
FTH_RS08530	COG3335	DDE superfamily endonuclease
FTH_RS08545	COG2890	protein-(glutamine-N5) methyltransferase activity
FTH_RS08550	COG2814	Major facilitator Superfamily
FTH_RS08555	COG0456	acetyltransferase
FTH_RS08565	COG3335	DDE superfamily endonuclease
FTH_RS08620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FTH_RS08625	COG1494	fructose-1,6-bisphosphatase
FTH_RS08630	COG2945	thiolester hydrolase activity
FTH_RS08635	COG0833	amino acid
FTH_RS08645	COG1674	ftsk spoiiie
FTH_RS08660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FTH_RS08685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FTH_RS08695	COG3335	DDE superfamily endonuclease
FTH_RS08725	COG3335	DDE superfamily endonuclease
FTH_RS08740	COG2890	protein-(glutamine-N5) methyltransferase activity
FTH_RS08760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FTH_RS08765	COG2814	Major facilitator Superfamily
FTH_RS08775	COG3023	N-Acetylmuramoyl-L-alanine amidase
FTH_RS08810	COG4974	Belongs to the 'phage' integrase family
FTH_RS08920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FTH_RS08935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FTH_RS08950	COG3335	DDE superfamily endonuclease
FTH_RS08975	COG1090	epimerase
FTH_RS08990	COG1294	oxidase, subunit
FTH_RS09000	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
FTH_RS09035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FTH_RS09060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FTH_RS09095	COG1053	succinate dehydrogenase
FTH_RS09100	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FTH_RS09115	COG2223	nitrite transmembrane transporter activity
FTH_RS09130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FTH_RS09190	COG0564	pseudouridine synthase activity
FTH_RS09195	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FTH_RS09220	COG2251	uridine kinase activity
FTH_RS09220	COG0195	Participates in both transcription termination and antitermination
FTH_RS09245	COG3335	DDE superfamily endonuclease
FTH_RS09280	COG0839	Belongs to the complex I subunit 6 family
FTH_RS09295	COG1034	ATP synthesis coupled electron transport
FTH_RS09305	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FTH_RS09325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FTH_RS09335	COG4264	IucA IucC family
FTH_RS09340	COG2814	Major facilitator Superfamily
FTH_RS09345	COG0019	diaminopimelate decarboxylase activity
FTH_RS09350	COG2814	Major facilitator Superfamily
FTH_RS09385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FTH_RS09405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FTH_RS09455	COG0047	phosphoribosylformylglycinamidine synthase activity
FTH_RS09455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FTH_RS09460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FTH_RS09475	COG1538	Outer membrane efflux protein
FTH_RS09485	COG0826	peptidase U32
FTH_RS09495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FTH_RS09505	COG0531	amino acid
FTH_RS09515	COG0814	amino acid
FTH_RS09545	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FTH_RS09575	COG3335	DDE superfamily endonuclease
FTH_RS09595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FTH_RS09605	COG3335	DDE superfamily endonuclease
FTH_RS09625	COG3040	lipid binding
FTH_RS09640	COG2066	Belongs to the glutaminase family
FTH_RS09650	COG2862	Uncharacterized protein family, UPF0114
FTH_RS09655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FTH_RS09665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FTH_RS09685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FTH_RS09705	COG0009	L-threonylcarbamoyladenylate synthase
FTH_RS09715	COG0204	Acyl-transferase
FTH_RS09730	COG1181	Belongs to the D-alanine--D-alanine ligase family
FTH_RS09745	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FTH_RS09765	COG3335	DDE superfamily endonuclease
FTH_RS09775	COG3293	Transposase
FTH_RS09785	COG0138	bifunctional purine biosynthesis protein purh
FTH_RS09810	COG1121	(ABC) transporter
FTH_RS09835	COG1295	ribonuclease BN
FTH_RS09845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FTH_RS09855	COG3335	DDE superfamily endonuclease
FTH_RS09865	COG0488	(ABC) transporter
FTH_RS09910	COG0308	aminopeptidase N
FTH_RS09915	COG0071	Belongs to the small heat shock protein (HSP20) family
FTH_RS09920	COG0134	indole-3-glycerol-phosphate synthase activity
FTH_RS09920	COG0135	phosphoribosylanthranilate isomerase activity
FTH_RS09930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FTH_RS09955	COG0512	Glutamine amidotransferase of anthranilate synthase
FTH_RS09960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FTH_RS09995	COG3335	DDE superfamily endonuclease
FTH_RS10015	COG3335	DDE superfamily endonuclease