locus-tag	class	description
B4919_RS00010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4919_RS00015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4919_RS00025	COG2814	Major facilitator Superfamily
B4919_RS00030	COG1271	oxidase subunit
B4919_RS00035	COG1294	oxidase, subunit
B4919_RS00045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4919_RS00060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4919_RS00070	COG1295	ribonuclease BN
B4919_RS00095	COG1121	(ABC) transporter
B4919_RS00120	COG0138	bifunctional purine biosynthesis protein purh
B4919_RS00125	COG0814	amino acid
B4919_RS00130	COG3676	manually curated
B4919_RS00140	COG3040	lipid binding
B4919_RS00155	COG2066	Belongs to the glutaminase family
B4919_RS00165	COG2862	Uncharacterized protein family, UPF0114
B4919_RS00175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4919_RS00185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4919_RS00205	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4919_RS00225	COG0009	L-threonylcarbamoyladenylate synthase
B4919_RS00235	COG0204	Acyl-transferase
B4919_RS00240	COG2333	competence protein COMEC
B4919_RS00240	COG0658	competence protein
B4919_RS00245	COG0189	ligase activity
B4919_RS00245	COG4067	protein conserved in archaea
B4919_RS00250	COG0456	acetyltransferase
B4919_RS00260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B4919_RS00295	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4919_RS00310	COG1116	anion transmembrane transporter activity
B4919_RS00350	COG0400	carboxylic ester hydrolase activity
B4919_RS00355	COG0557	exoribonuclease II activity
B4919_RS00365	COG3676	manually curated
B4919_RS00375	COG3676	manually curated
B4919_RS00380	COG0438	transferase activity, transferring glycosyl groups
B4919_RS00385	COG3676	manually curated
B4919_RS00400	COG1012	belongs to the aldehyde dehydrogenase family
B4919_RS00405	COG0857	belongs to the CobB CobQ family
B4919_RS00405	COG0280	phosphate acetyltransferase
B4919_RS00415	COG0629	single-stranded DNA binding
B4919_RS00420	COG2137	regulation of response to DNA damage stimulus
B4919_RS00445	COG0616	signal peptide processing
B4919_RS00445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B4919_RS00455	COG3961	Belongs to the TPP enzyme family
B4919_RS00475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4919_RS00475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4919_RS00485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4919_RS00485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4919_RS00495	COG0242	peptide deformylase activity
B4919_RS00505	COG3676	manually curated
B4919_RS00530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4919_RS00535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B4919_RS00545	COG2814	Major facilitator Superfamily
B4919_RS00570	COG0814	amino acid
B4919_RS00580	COG0778	Nitroreductase
B4919_RS00595	COG3038	cytochrome b561
B4919_RS00610	COG3676	manually curated
B4919_RS00620	COG1984	allophanate hydrolase subunit 2
B4919_RS00640	COG0589	response to stress
B4919_RS00670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4919_RS00680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4919_RS00695	COG0594	ribonuclease P activity
B4919_RS00710	COG1560	Kdo2-lipid A biosynthetic process
B4919_RS00715	COG1560	Kdo2-lipid A biosynthetic process
B4919_RS00740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4919_RS00750	COG0574	Belongs to the PEP-utilizing enzyme family
B4919_RS00750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4919_RS00760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4919_RS00765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4919_RS00775	COG0473	3-isopropylmalate dehydrogenase activity
B4919_RS00780	COG1621	beta-fructofuranosidase activity
B4919_RS00825	COG0583	DNA-binding transcription factor activity
B4919_RS00835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4919_RS00880	COG0505	Belongs to the CarA family
B4919_RS00885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4919_RS00890	COG0540	Belongs to the ATCase OTCase family
B4919_RS00905	COG0814	amino acid
B4919_RS00915	COG0582	viral genome integration into host DNA
B4919_RS00925	COG3311	Transcriptional regulator
B4919_RS00980	COG0531	amino acid
B4919_RS00985	COG0477	Major facilitator Superfamily
B4919_RS01025	COG0512	Glutamine amidotransferase of anthranilate synthase
B4919_RS01060	COG0135	phosphoribosylanthranilate isomerase activity
B4919_RS01060	COG0134	indole-3-glycerol-phosphate synthase activity
B4919_RS01065	COG0071	Belongs to the small heat shock protein (HSP20) family
B4919_RS01070	COG0308	aminopeptidase N
B4919_RS01075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4919_RS01095	COG0477	Major facilitator Superfamily
B4919_RS01100	COG0488	(ABC) transporter
B4919_RS01110	COG0604	alcohol dehydrogenase
B4919_RS01110	COG3321	synthase
B4919_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
B4919_RS01125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4919_RS01130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4919_RS01135	COG0477	Major facilitator Superfamily
B4919_RS01160	COG0204	Acyl-transferase
B4919_RS01170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B4919_RS01200	COG0542	response to heat
B4919_RS01225	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4919_RS01255	COG0084	hydrolase, TatD family'
B4919_RS01265	COG0527	aspartate kinase activity
B4919_RS01270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B4919_RS01280	COG2171	N-acyltransferase activity
B4919_RS01290	COG0436	Aminotransferase
B4919_RS01335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B4919_RS01340	COG2205	protein histidine kinase activity
B4919_RS01365	COG0814	amino acid
B4919_RS01375	COG0531	amino acid
B4919_RS01380	COG4178	(ABC) transporter
B4919_RS01385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4919_RS01395	COG0826	peptidase U32
B4919_RS01405	COG1538	Outer membrane efflux protein
B4919_RS01415	COG0076	glutamate decarboxylase activity
B4919_RS01420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B4919_RS01425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4919_RS01425	COG0047	phosphoribosylformylglycinamidine synthase activity
B4919_RS01450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4919_RS01470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4919_RS01495	COG3240	lipase activity
B4919_RS01505	COG2814	Major facilitator Superfamily
B4919_RS01510	COG0019	diaminopimelate decarboxylase activity
B4919_RS01515	COG2814	Major facilitator Superfamily
B4919_RS01520	COG4264	IucA IucC family
B4919_RS01530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4919_RS01550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B4919_RS01560	COG1034	ATP synthesis coupled electron transport
B4919_RS01575	COG0839	Belongs to the complex I subunit 6 family
B4919_RS01625	COG0195	Participates in both transcription termination and antitermination
B4919_RS01625	COG2251	uridine kinase activity
B4919_RS01650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B4919_RS01740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B4919_RS01755	COG2223	nitrite transmembrane transporter activity
B4919_RS01770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B4919_RS01775	COG1053	succinate dehydrogenase
B4919_RS01790	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4919_RS01810	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4919_RS01830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4919_RS01860	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B4919_RS01870	COG1294	oxidase, subunit
B4919_RS01875	COG1271	oxidase subunit
B4919_RS01880	COG1090	epimerase
B4919_RS01920	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4919_RS01940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4919_RS01945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4919_RS01970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4919_RS01970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4919_RS01980	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B4919_RS01985	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4919_RS01990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4919_RS01995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4919_RS02015	COG0552	protein localization to endoplasmic reticulum
B4919_RS02020	COG0210	DNA helicase
B4919_RS02025	COG4166	transmembrane transport
B4919_RS02030	COG0601	transmembrane transport
B4919_RS02035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4919_RS02040	COG0444	Belongs to the ABC transporter superfamily
B4919_RS02045	COG4608	Belongs to the ABC transporter superfamily
B4919_RS02050	COG2814	Major facilitator Superfamily
B4919_RS02075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4919_RS02090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4919_RS02120	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4919_RS02200	COG4974	Belongs to the 'phage' integrase family
B4919_RS02235	COG3023	N-Acetylmuramoyl-L-alanine amidase
B4919_RS02245	COG2814	Major facilitator Superfamily
B4919_RS02250	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4919_RS02270	COG2890	protein-(glutamine-N5) methyltransferase activity
B4919_RS02345	COG0300	oxidoreductase activity
B4919_RS02375	COG2081	HI0933 family
B4919_RS02380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4919_RS02395	COG0531	amino acid
B4919_RS02405	COG0398	Pfam SNARE associated Golgi protein
B4919_RS02410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4919_RS02415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4919_RS02425	COG0531	amino acid
B4919_RS02440	COG0814	amino acid
B4919_RS02455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4919_RS02480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B4919_RS02485	COG0814	amino acid
B4919_RS02535	COG3676	manually curated
B4919_RS02570	COG0237	dephospho-CoA kinase activity
B4919_RS02585	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4919_RS02590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4919_RS02620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4919_RS02640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B4919_RS02660	COG1472	Belongs to the glycosyl hydrolase 3 family
B4919_RS02675	COG1183	phosphatidylcholine synthase activity
B4919_RS02685	COG1519	Transferase
B4919_RS02690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4919_RS02695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4919_RS02700	COG2828	Protein conserved in bacteria
B4919_RS02710	COG0681	Belongs to the peptidase S26 family
B4919_RS02725	COG0557	exoribonuclease II activity
B4919_RS02750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B4919_RS02770	COG0745	RESPONSE REGULATOR receiver
B4919_RS02835	COG0183	Belongs to the thiolase family
B4919_RS02840	COG1024	Enoyl-CoA hydratase
B4919_RS02840	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4919_RS02845	COG1960	acyl-CoA dehydrogenase activity
B4919_RS02850	COG0318	PFAM AMP-dependent synthetase and ligase
B4919_RS02855	COG1393	Belongs to the ArsC family
B4919_RS02870	COG1643	Atp-dependent helicase
B4919_RS02875	COG1086	Polysaccharide biosynthesis protein
B4919_RS02895	COG1086	Polysaccharide biosynthesis protein
B4919_RS02900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4919_RS02920	COG0463	Glycosyl transferase, family 2
B4919_RS02930	COG1216	Glycosyl transferase, family 2
B4919_RS02930	COG1442	glycosyl transferase family 8
B4919_RS02950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B4919_RS02960	COG1088	dTDP-glucose 4,6-dehydratase activity
B4919_RS02965	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B4919_RS02965	COG0662	Cupin 2, conserved barrel domain protein
B4919_RS02980	COG3118	belongs to the thioredoxin family
B4919_RS02985	COG0248	Ppx GppA phosphatase
B4919_RS02990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4919_RS03005	COG3676	manually curated
B4919_RS03020	COG0084	hydrolase, TatD family'
B4919_RS03035	COG1131	(ABC) transporter
B4919_RS03040	COG0842	Transport permease protein
B4919_RS03045	COG0463	Glycosyl transferase, family 2
B4919_RS03055	COG1280	lysine exporter protein (LysE YggA)
B4919_RS03090	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B4919_RS03100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4919_RS03105	COG0446	pyridine nucleotide-disulphide oxidoreductase
B4919_RS03125	COG2983	Belongs to the UPF0260 family
B4919_RS03165	COG3676	manually curated
B4919_RS03170	COG0436	Aminotransferase
B4919_RS03190	COG3676	manually curated
B4919_RS03220	COG3676	manually curated
B4919_RS03225	COG2166	iron-sulfur cluster assembly
B4919_RS03290	COG0697	spore germination
B4919_RS03295	COG0069	glutamate synthase activity
B4919_RS03300	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B4919_RS03310	COG1074	ATP-dependent DNA helicase activity
B4919_RS03315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4919_RS03365	COG0483	inositol monophosphate 1-phosphatase activity
B4919_RS03370	COG2855	membrane
B4919_RS03380	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B4919_RS03380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4919_RS03390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4919_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
B4919_RS03405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4919_RS03445	COG0469	pyruvate kinase activity
B4919_RS03450	COG0191	fructose-bisphosphate aldolase activity
B4919_RS03460	COG0738	Major facilitator superfamily
B4919_RS03580	COG3676	manually curated
B4919_RS03585	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4919_RS03600	COG0583	DNA-binding transcription factor activity
B4919_RS03655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4919_RS03670	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B4919_RS03690	COG0583	DNA-binding transcription factor activity
B4919_RS03710	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4919_RS03725	COG0477	Major facilitator Superfamily
B4919_RS03735	COG0318	PFAM AMP-dependent synthetase and ligase
B4919_RS03745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4919_RS03765	COG1127	ABC transporter
B4919_RS03770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B4919_RS03775	COG2992	FlgJ-related protein
B4919_RS03780	COG0564	pseudouridine synthase activity
B4919_RS03785	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4919_RS03810	COG3028	Belongs to the UPF0307 family
B4919_RS03840	COG3104	oligopeptide transport
B4919_RS03850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4919_RS03865	COG1530	ribonuclease E activity
B4919_RS03885	COG3676	manually curated
B4919_RS03890	COG0586	Pfam SNARE associated Golgi protein
B4919_RS03895	COG0586	Pfam SNARE associated Golgi protein
B4919_RS03915	COG3079	Belongs to the UPF0149 family
B4919_RS03925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4919_RS03940	COG0561	phosphatase activity
B4919_RS03945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4919_RS03950	COG0346	lactoylglutathione lyase activity
B4919_RS03965	COG1611	Belongs to the LOG family
B4919_RS03985	COG3220	belongs to the UPF0276 family
B4919_RS04000	COG0517	IMP dehydrogenase activity
B4919_RS04000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B4919_RS04005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4919_RS04010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4919_RS04015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4919_RS04025	COG1132	(ABC) transporter
B4919_RS04040	COG3475	LICD family
B4919_RS04045	COG1442	glycosyl transferase family 8
B4919_RS04045	COG1216	Glycosyl transferase, family 2
B4919_RS04050	COG1442	glycosyl transferase family 8
B4919_RS04050	COG1216	Glycosyl transferase, family 2
B4919_RS04055	COG0438	transferase activity, transferring glycosyl groups
B4919_RS04075	COG1446	asparaginase
B4919_RS04105	COG0477	Major facilitator Superfamily
B4919_RS04125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4919_RS04145	COG0509	glycine decarboxylation via glycine cleavage system
B4919_RS04155	COG3397	chitin binding
B4919_RS04160	COG3676	manually curated
B4919_RS04190	COG3590	peptidase
B4919_RS04195	COG3676	manually curated
B4919_RS04235	COG4221	oxidoreductase activity
B4919_RS04240	COG2925	Exonuclease
B4919_RS04260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B4919_RS04280	COG0352	thiamine-phosphate diphosphorylase activity
B4919_RS04290	COG0477	Major facilitator Superfamily
B4919_RS04295	COG2308	Evidence 4 Homologs of previously reported genes of
B4919_RS04310	COG1473	amidohydrolase
B4919_RS04325	COG0477	Major facilitator Superfamily
B4919_RS04340	COG2867	negative regulation of translational initiation
B4919_RS04345	COG2914	Belongs to the UPF0125 (RnfH) family
B4919_RS04350	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B4919_RS04350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4919_RS04360	COG0405	Gamma-glutamyltransferase
B4919_RS04385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4919_RS04390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4919_RS04395	COG1214	PFAM Peptidase M22, glycoprotease
B4919_RS04405	COG0436	Aminotransferase
B4919_RS04410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4919_RS04420	COG0277	FAD linked oxidase domain protein
B4919_RS04480	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B4919_RS04490	COG0531	amino acid
B4919_RS04495	COG2814	Major facilitator Superfamily
B4919_RS04500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4919_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
B4919_RS04540	COG3676	manually curated
B4919_RS04545	COG0415	Belongs to the DNA photolyase family
B4919_RS04565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4919_RS04575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4919_RS04590	COG0189	ligase activity
B4919_RS04590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4919_RS04595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4919_RS04595	COG0189	ligase activity
B4919_RS04605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4919_RS04610	COG0814	amino acid
B4919_RS04615	COG1464	Belongs to the NlpA lipoprotein family
B4919_RS04655	COG3676	manually curated
B4919_RS04675	COG0583	DNA-binding transcription factor activity
B4919_RS04685	COG1335	isochorismatase
B4919_RS04695	COG1862	Preprotein translocase
B4919_RS04700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4919_RS04705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4919_RS04715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4919_RS04720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4919_RS04735	COG0252	asparaginase activity
B4919_RS04740	COG0288	reversible hydration of carbon dioxide
B4919_RS04750	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B4919_RS04755	COG1773	rubredoxin
B4919_RS04770	COG1823	symporter activity
B4919_RS04775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4919_RS04780	COG2814	Major facilitator Superfamily
B4919_RS04785	COG3676	manually curated
B4919_RS04800	COG1496	oxidoreductase activity
B4919_RS04895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B4919_RS04900	COG4535	Mg2 and Co2 transporter CorC
B4919_RS04910	COG1702	phosphate starvation-inducible protein PhoH
B4919_RS04920	COG4122	O-methyltransferase activity
B4919_RS04950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4919_RS04955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4919_RS04980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4919_RS04990	COG0330	HflC and HflK could
B4919_RS04995	COG0330	HflC and HflK could
B4919_RS05000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4919_RS05015	COG0129	dihydroxy-acid dehydratase activity
B4919_RS05020	COG0028	Belongs to the TPP enzyme family
B4919_RS05030	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4919_RS05035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4919_RS05040	COG0670	Belongs to the BI1 family
B4919_RS05055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4919_RS05060	COG2878	Part of a membrane complex involved in electron transport
B4919_RS05065	COG2999	glutathione oxidoreductase activity
B4919_RS05070	COG3104	oligopeptide transport
B4919_RS05075	COG1528	Iron-storage protein
B4919_RS05085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B4919_RS05100	COG2271	Major facilitator Superfamily
B4919_RS05110	COG1322	Protein conserved in bacteria
B4919_RS05135	COG0076	glutamate decarboxylase activity
B4919_RS05175	COG2271	Major facilitator Superfamily
B4919_RS05190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4919_RS05200	COG4536	flavin adenine dinucleotide binding
B4919_RS05210	COG0012	GTP binding
B4919_RS05230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4919_RS05250	COG3676	manually curated
B4919_RS05265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B4919_RS05275	COG0095	Lipoate-protein ligase
B4919_RS05280	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4919_RS05290	COG3961	Belongs to the TPP enzyme family
B4919_RS05295	COG0277	FAD linked oxidase domain protein
B4919_RS05300	COG1979	alcohol dehydrogenase
B4919_RS05305	COG2264	protein methyltransferase activity
B4919_RS05310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4919_RS05330	COG0488	(ABC) transporter
B4919_RS05340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B4919_RS05370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4919_RS05385	COG0450	alkyl hydroperoxide reductase
B4919_RS05395	COG2824	Alkylphosphonate utilization operon protein PhnA
B4919_RS05415	COG1876	peptidase activity
B4919_RS05425	COG1473	amidohydrolase
B4919_RS05435	COG1012	belongs to the aldehyde dehydrogenase family
B4919_RS05445	COG1937	Protein conserved in bacteria
B4919_RS05455	COG0583	DNA-binding transcription factor activity
B4919_RS05475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4919_RS05525	COG1187	pseudouridine synthase activity
B4919_RS05550	COG0529	Catalyzes the synthesis of activated sulfate
B4919_RS05560	COG0367	asparagine synthase
B4919_RS05575	COG1132	(ABC) transporter
B4919_RS05595	COG0175	sulfate reduction
B4919_RS05615	COG0529	Catalyzes the synthesis of activated sulfate
B4919_RS05640	COG0142	geranyltranstransferase activity
B4919_RS05645	COG3676	manually curated
B4919_RS05670	COG2027	D-alanyl-D-alanine carboxypeptidase
B4919_RS05680	COG1610	YqeY-like protein
B4919_RS05685	COG0358	DNA primase activity
B4919_RS05700	COG1501	Belongs to the glycosyl hydrolase 31 family
B4919_RS05715	COG2921	Belongs to the UPF0250 family
B4919_RS05720	COG1686	Belongs to the peptidase S11 family
B4919_RS05725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B4919_RS05730	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B4919_RS05745	COG1137	ATPase activity
B4919_RS05750	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4919_RS05755	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B4919_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
B4919_RS05810	COG3655	Transcriptional regulator
B4919_RS05835	COG2814	Major facilitator Superfamily
B4919_RS05840	COG1904	glucuronate isomerase
B4919_RS05860	COG0246	Mannitol dehydrogenase
B4919_RS05870	COG2211	Major facilitator Superfamily
B4919_RS05875	COG3104	oligopeptide transport
B4919_RS05880	COG0697	spore germination
B4919_RS05890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4919_RS05890	COG0072	phenylalanine-tRNA ligase activity
B4919_RS05895	COG0735	belongs to the Fur family
B4919_RS05900	COG0523	cobalamin synthesis protein
B4919_RS05915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4919_RS05920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4919_RS05930	COG0489	protein tyrosine kinase activity
B4919_RS05940	COG0668	transmembrane transport
B4919_RS05970	COG3676	manually curated
B4919_RS06010	COG0833	amino acid
B4919_RS06040	COG1834	amidinotransferase
B4919_RS06045	COG0719	Fe-S assembly protein
B4919_RS06050	COG0396	ATPase activity
B4919_RS06055	COG0719	Fe-S assembly protein
B4919_RS06065	COG0569	domain protein
B4919_RS06070	COG0531	amino acid
B4919_RS06095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4919_RS06100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B4919_RS06110	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4919_RS06120	COG0708	Exodeoxyribonuclease III
B4919_RS06140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4919_RS06150	COG3104	oligopeptide transport
B4919_RS06155	COG0513	Belongs to the DEAD box helicase family
B4919_RS06160	COG0302	gtp cyclohydrolase
B4919_RS06175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4919_RS06180	COG0667	Aldo Keto reductase
B4919_RS06195	COG0512	Glutamine amidotransferase of anthranilate synthase
B4919_RS06195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4919_RS06200	COG0512	Glutamine amidotransferase of anthranilate synthase
B4919_RS06200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4919_RS06210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4919_RS06215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4919_RS06215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4919_RS06230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4919_RS06240	COG0156	8-amino-7-oxononanoate synthase activity
B4919_RS06275	COG1028	Short-chain dehydrogenase reductase Sdr
B4919_RS06280	COG1472	Belongs to the glycosyl hydrolase 3 family
B4919_RS06290	COG0189	ligase activity
B4919_RS06310	COG0798	PFAM Bile acid sodium symporter
B4919_RS06315	COG2076	Multidrug Resistance protein
B4919_RS06335	COG0582	viral genome integration into host DNA
B4919_RS06345	COG1002	Type II restriction enzyme, methylase subunits
B4919_RS06365	COG1061	Type III restriction enzyme res subunit
B4919_RS06370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4919_RS06390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B4919_RS06415	COG1396	sequence-specific DNA binding
B4919_RS06420	COG1396	sequence-specific DNA binding
B4919_RS06425	COG3550	peptidyl-serine autophosphorylation
B4919_RS06450	COG3676	manually curated
B4919_RS06470	COG2974	May be involved in recombination
B4919_RS06480	COG2996	Protein conserved in bacteria
B4919_RS06485	COG0210	DNA helicase
B4919_RS06490	COG0354	folic acid binding
B4919_RS06495	COG3676	manually curated
B4919_RS06520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4919_RS06525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4919_RS06545	COG0210	DNA helicase
B4919_RS06575	COG2814	Major facilitator Superfamily
B4919_RS06580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4919_RS06585	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B4919_RS06590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4919_RS06595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4919_RS06620	COG0535	radical SAM domain protein
B4919_RS06650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B4919_RS06660	COG2151	metal-sulfur cluster biosynthetic enzyme
B4919_RS06665	COG0316	Belongs to the HesB IscA family
B4919_RS06670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4919_RS06675	COG1760	l-serine dehydratase
B4919_RS06685	COG1605	Chorismate mutase
B4919_RS06685	COG0077	Prephenate dehydratase
B4919_RS06690	COG0531	amino acid
B4919_RS06715	COG0560	Phosphoserine phosphatase
B4919_RS06725	COG0297	glycogen (starch) synthase activity
B4919_RS06730	COG3676	manually curated
B4919_RS06745	COG3676	manually curated
B4919_RS06750	COG3842	ATPase activity
B4919_RS06755	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4919_RS06760	COG1177	transmembrane transport
B4919_RS06780	COG0751	glycine-tRNA ligase activity
B4919_RS06785	COG0084	hydrolase, TatD family'
B4919_RS06815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4919_RS06820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4919_RS06835	COG3676	manually curated
B4919_RS06855	COG3676	manually curated
B4919_RS06860	COG1278	Cold shock
B4919_RS06865	COG0686	Belongs to the AlaDH PNT family
B4919_RS06870	COG1509	lysine 2,3-aminomutase activity
B4919_RS06905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4919_RS06915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4919_RS06960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B4919_RS06960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B4919_RS06990	COG0386	Belongs to the glutathione peroxidase family
B4919_RS07005	COG3676	manually curated
B4919_RS07025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B4919_RS07035	COG0513	Belongs to the DEAD box helicase family
B4919_RS07040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4919_RS07045	COG2814	Major facilitator Superfamily
B4919_RS07050	COG2814	Major facilitator Superfamily
B4919_RS07055	COG1085	galactose-1-phosphate uridylyltransferase
B4919_RS07090	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B4919_RS07095	COG2814	Major facilitator Superfamily
B4919_RS07145	COG0813	purine-nucleoside phosphorylase activity
B4919_RS07150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4919_RS07160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4919_RS07185	COG0516	GMP reductase activity
B4919_RS07185	COG0517	IMP dehydrogenase activity
B4919_RS07195	COG0795	lipopolysaccharide-transporting ATPase activity
B4919_RS07200	COG0795	lipopolysaccharide-transporting ATPase activity
B4919_RS07215	COG0742	ribosomal rna small subunit methyltransferase
B4919_RS07220	COG2860	membrane
B4919_RS07230	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B4919_RS07235	COG0295	cytidine deaminase activity
B4919_RS07245	COG0247	lactate metabolic process
B4919_RS07245	COG0277	FAD linked oxidase domain protein
B4919_RS07260	COG1940	carbohydrate kinase activity
B4919_RS07280	COG4988	ABC transporter
B4919_RS07285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4919_RS07295	COG0251	oxidation-reduction process
B4919_RS07300	COG0659	secondary active sulfate transmembrane transporter activity
B4919_RS07305	COG0842	Transport permease protein
B4919_RS07310	COG1131	(ABC) transporter
B4919_RS07320	COG3676	manually curated
B4919_RS07330	COG3676	manually curated
B4919_RS07335	COG0584	glycerophosphoryl diester phosphodiesterase
B4919_RS07340	COG2271	Major facilitator Superfamily
B4919_RS07345	COG1686	Belongs to the peptidase S11 family
B4919_RS07350	COG3676	manually curated
B4919_RS07360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B4919_RS07365	COG0477	Major facilitator Superfamily
B4919_RS07395	COG0788	formyltetrahydrofolate deformylase activity
B4919_RS07415	COG0156	8-amino-7-oxononanoate synthase activity
B4919_RS07425	COG0814	amino acid
B4919_RS07430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B4919_RS07435	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B4919_RS07455	COG1940	carbohydrate kinase activity
B4919_RS07530	COG3116	cell division
B4919_RS07540	COG0318	PFAM AMP-dependent synthetase and ligase
B4919_RS07540	COG0204	Acyl-transferase
B4919_RS07545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4919_RS07570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4919_RS07590	COG3676	manually curated
B4919_RS07605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4919_RS07620	COG0628	permease
B4919_RS07630	COG3104	oligopeptide transport
B4919_RS07635	COG1446	asparaginase
B4919_RS07645	COG3142	Participates in the control of copper homeostasis
B4919_RS07650	COG3676	manually curated
B4919_RS07655	COG2814	Major facilitator Superfamily
B4919_RS07660	COG0583	DNA-binding transcription factor activity
B4919_RS07665	COG0546	phosphoglycolate phosphatase activity
B4919_RS07670	COG3676	manually curated
B4919_RS07680	COG0492	ferredoxin-NADP+ reductase activity
B4919_RS07695	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B4919_RS07710	COG1162	GTPase activity
B4919_RS07725	COG0531	amino acid
B4919_RS07735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4919_RS07740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4919_RS07740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4919_RS07760	COG0439	Biotin carboxylase
B4919_RS07775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4919_RS07785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4919_RS07805	COG0252	asparaginase activity
B4919_RS07810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4919_RS07815	COG0113	porphobilinogen synthase activity
B4919_RS07825	COG0470	DNA polymerase III
B4919_RS07830	COG0616	signal peptide processing
B4919_RS07835	COG0625	glutathione transferase activity
B4919_RS07840	COG2920	part of a sulfur-relay system
B4919_RS07850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B4919_RS07855	COG3676	manually curated
B4919_RS07860	COG0463	Glycosyl transferase, family 2
B4919_RS07870	COG0772	Belongs to the SEDS family
B4919_RS07885	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B4919_RS07890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4919_RS07900	COG3104	oligopeptide transport
B4919_RS07905	COG0488	(ABC) transporter
B4919_RS07920	COG2814	Major facilitator Superfamily
B4919_RS07930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4919_RS07935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4919_RS07940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B4919_RS07970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4919_RS07980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4919_RS07985	COG0083	homoserine kinase activity
B4919_RS07990	COG0527	aspartate kinase activity
B4919_RS07990	COG0460	homoserine dehydrogenase
B4919_RS07995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4919_RS08005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4919_RS08015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4919_RS08025	COG1640	4-alpha-glucanotransferase
B4919_RS08030	COG0058	SHG alpha-glucan phosphorylase activity
B4919_RS08045	COG0033	Phosphoglucomutase
B4919_RS08055	COG1523	belongs to the glycosyl hydrolase 13 family
B4919_RS08080	COG3676	manually curated
B4919_RS08100	COG0509	glycine decarboxylation via glycine cleavage system
B4919_RS08110	COG1982	Orn Lys Arg decarboxylase major
B4919_RS08130	COG0242	peptide deformylase activity
B4919_RS08135	COG0587	DNA-directed DNA polymerase activity
B4919_RS08145	COG2801	Transposase and inactivated derivatives
B4919_RS08160	COG4948	Mandelate Racemase Muconate Lactonizing
B4919_RS08165	COG2271	Major facilitator Superfamily
B4919_RS08170	COG1012	belongs to the aldehyde dehydrogenase family
B4919_RS08180	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B4919_RS08195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4919_RS08200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4919_RS08215	COG0024	Methionine aminopeptidase
B4919_RS08240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4919_RS08250	COG1051	belongs to the nudix hydrolase family
B4919_RS08250	COG1056	cytidyltransferase-related domain
B4919_RS08270	COG3676	manually curated
B4919_RS08280	COG1994	Peptidase M50
B4919_RS08295	COG3676	manually curated
B4919_RS08325	COG3676	manually curated
B4919_RS08350	COG2271	Major facilitator Superfamily
B4919_RS08355	COG1739	Uncharacterized protein family UPF0029
B4919_RS08360	COG0009	L-threonylcarbamoyladenylate synthase
B4919_RS08365	COG2917	probably involved in intracellular septation
B4919_RS08370	COG3676	manually curated
B4919_RS08380	COG0837	glucose binding
B4919_RS08395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B4919_RS08400	COG0537	adenosine 5'-monophosphoramidase activity
B4919_RS08410	COG1040	competence protein
B4919_RS08415	COG2226	methyltransferase
B4919_RS08425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4919_RS08430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4919_RS08460	COG0281	malic enzyme
B4919_RS08465	COG0196	riboflavin kinase activity
B4919_RS08500	COG0519	Catalyzes the synthesis of GMP from XMP
B4919_RS08505	COG1475	DNA binding
B4919_RS08510	COG1192	Involved in chromosome partitioning
B4919_RS08550	COG0339	signal peptide processing
B4919_RS08570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4919_RS08580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4919_RS08595	COG0671	phosphoesterase, PA-phosphatase related
B4919_RS08600	COG4969	Belongs to the N-Me-Phe pilin family
B4919_RS08615	COG0497	DNA recombination
B4919_RS08625	COG0436	Aminotransferase
B4919_RS08630	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B4919_RS08640	COG0833	amino acid
B4919_RS08655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4919_RS08655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4919_RS08725	COG1704	LemA family
B4919_RS08730	COG0501	Belongs to the peptidase M48B family
B4919_RS08770	COG2363	Small membrane protein
B4919_RS08775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4919_RS08800	COG0385	Bile acid
B4919_RS08805	COG3676	manually curated
B4919_RS08820	COG0415	Belongs to the DNA photolyase family
B4919_RS08835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4919_RS08865	COG0811	peptide transport
B4919_RS08875	COG1183	phosphatidylcholine synthase activity
B4919_RS08880	COG4401	Chorismate mutase type I
B4919_RS08900	COG0758	DNA mediated transformation
B4919_RS08905	COG2985	domain, Protein
B4919_RS08935	COG1051	belongs to the nudix hydrolase family
B4919_RS08940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B4919_RS08950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4919_RS08970	COG0850	regulation of cytokinetic process
B4919_RS08985	COG1127	ABC transporter
B4919_RS08990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B4919_RS08995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B4919_RS09015	COG2853	Lipoprotein
B4919_RS09020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4919_RS09035	COG0531	amino acid
B4919_RS09065	COG3676	manually curated
B4919_RS09070	COG0456	acetyltransferase
B4919_RS09075	COG2814	Major facilitator Superfamily
B4919_RS09080	COG2890	protein-(glutamine-N5) methyltransferase activity
B4919_RS09135	COG1253	flavin adenine dinucleotide binding
B4919_RS09145	COG3676	manually curated
B4919_RS09150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4919_RS09155	COG1494	fructose-1,6-bisphosphatase
B4919_RS09160	COG2945	thiolester hydrolase activity
B4919_RS09165	COG0833	amino acid
B4919_RS09175	COG1674	ftsk spoiiie
B4919_RS09190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4919_RS09210	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4919_RS09235	COG0732	type I restriction modification DNA specificity domain
B4919_RS09245	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B4919_RS09275	COG2918	glutathione biosynthetic process
B4919_RS09280	COG0728	peptidoglycan biosynthetic process
B4919_RS09290	COG0802	atpase or kinase
B4919_RS09295	COG0285	dihydrofolate synthase activity
B4919_RS09300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4919_RS09315	COG1288	antiporter activity
B4919_RS09360	COG0201	protein transport
B4919_RS09485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4919_RS09495	COG0575	Belongs to the CDS family
B4919_RS09500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4919_RS09525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4919_RS09540	COG0531	amino acid
B4919_RS09560	COG0114	fumarate hydratase activity
B4919_RS09575	COG1304	FMN binding
B4919_RS09585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B4919_RS09595	COG0525	valine-tRNA ligase activity
B4919_RS09610	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B4919_RS09625	COG2304	oxidoreductase activity
B4919_RS09645	COG0714	Associated with various cellular activities
B4919_RS09655	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B4919_RS09675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor